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Whether you need a table for projects, eating or preparing a meal, the Canyon Table is strong and ready for rough handling. Made from lightweight aluminum with telescoping legs the Canyon Table is portable and convenient.. Compact when closed, the Canyon Table opens up to a roomy 27-inches x 27.5-inches spread. The large, smooth surface is flat and sturdy enough for dining, game-play or even as a handy workbench for outdoor projects.
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A Japanese Buzz in the Bronx
By Vijai Singh and David Waldstein | May. 30, 2014 | 2:34
The Yankees have three prominent Japanese players, led by Masahiro Tanaka, who is creating a stir in his first year in the majors. As a result, a large Japanese media contingent is often present.
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Most Popular "Dutch Angle" Titles
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- In Theaters
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1. Fight Club (1999)
R | 139 min | Drama
An insomniac office worker, looking for a way to change his life, crosses paths with a devil-may-care soap maker, forming an underground fight club that evolves into something much, much more...
Writers: Chuck Palahniuk, Jim Uhls | Director: David Fincher | Stars: Brad Pitt, Edward Norton, Helena Bonham Carter, Meat Loaf
Votes: 1,209,728
2. Thor (2011)
PG-13 | 115 min | Action, Adventure, Fantasy
The powerful but arrogant god Thor is cast out of Asgard to live amongst humans in Midgard (Earth), where he soon becomes one of their finest defenders.
Writers: Ashley Miller, Zack Stentz, Don Payne, J. Michael Straczynski, Mark Protosevich, Stan Lee, Larry Lieber, Jack Kirby | Director: Kenneth Branagh | Stars: Chris Hemsworth, Anthony Hopkins, Natalie Portman, Tom Hiddleston
Votes: 479,169
3. Star Trek Into Darkness (2013)
PG-13 | 132 min | Action, Adventure, Sci-Fi
After the crew of the Enterprise find an unstoppable force of terror from within their own organization, Captain Kirk leads a manhunt to a war-zone world to capture a one-man weapon of mass destruction.
Writers: Roberto Orci, Alex Kurtzman, Damon Lindelof, Gene Roddenberry | Director: J.J. Abrams | Stars: Chris Pine, Zachary Quinto, Zoe Saldana, Benedict Cumberbatch
Votes: 364,575
4. The Amazing Spider-Man 2 (2014)
PG-13 | 142 min | Action, Adventure, Fantasy
When New York is put under siege by Oscorp, it is up to Spider-Man to save the city he swore to protect as well as his loved ones.
Writers: Alex Kurtzman, Roberto Orci, Jeff Pinkner, James Vanderbilt, Stan Lee, Steve Ditko | Director: Marc Webb | Stars: Andrew Garfield, Emma Stone, Jamie Foxx, Paul Giamatti
Votes: 287,911
5. Mission: Impossible (1996)
PG-13 | 110 min | Action, Adventure, Thriller
An American agent, under false suspicion of disloyalty, must discover and expose the real spy without the help of his organization.
Writers: Bruce Geller, David Koepp, Steven Zaillian, Robert Towne | Director: Brian De Palma | Stars: Tom Cruise, Jon Voight, Emmanuelle Béart, Henry Czerny
Votes: 276,145
6. Batman Forever (1995)
PG-13 | 121 min | Action, Adventure, Fantasy
Batman must battle Two-Face and The Riddler with help of an amourous psychologist and a young circus acrobat who becomes his sidekick, Robin.
Writers: Bob Kane, Lee Batchler, Janet Scott Batchler, Akiva Goldsman | Director: Joel Schumacher | Stars: Val Kilmer, Tommy Lee Jones, Jim Carrey, Nicole Kidman
Votes: 177,493
7. Twelve Monkeys (1995)
R | 129 min | Mystery, Sci-Fi, Thriller
In a future world devastated by disease, a convict is sent back in time to gather information about the man-made virus that wiped out most of the human population on the planet.
Writers: Chris Marker, David Webb Peoples, Janet Peoples | Director: Terry Gilliam | Stars: Bruce Willis, Madeleine Stowe, Brad Pitt, Joseph Melito
Votes: 424,758
8. Carrie (2013)
R | 100 min | Drama, Horror
A reimagining of the classic horror tale about Carrie White, a shy girl outcast by her peers and sheltered by her deeply religious mother, who unleashes telekinetic terror on her small town after being pushed too far at her senior prom.
Writers: Lawrence D. Cohen, Roberto Aguirre-Sacasa, Stephen King | Director: Kimberly Peirce | Stars: Chloë Grace Moretz, Julianne Moore, Gabriella Wilde, Portia Doubleday
Votes: 99,378
9. Casino (1995)
R | 178 min | Biography, Crime, Drama
Greed, deception, money, power, and murder occur between two mobster best friends and a trophy wife over a gambling empire.
Writers: Nicholas Pileggi, Martin Scorsese | Director: Martin Scorsese | Stars: Robert De Niro, Sharon Stone, Joe Pesci, James Woods
Votes: 301,917
10. The Bank Job (2008)
R | 111 min | Crime, Drama, Thriller
Martine offers Terry a lead on a foolproof bank hit on London's Baker Street. She targets a roomful of safe deposit boxes worth millions in cash and jewelry. But Terry and his crew don't realize the boxes also contain a treasure trove of dirty secrets - secrets that will thrust them into a deadly web of corruption and illicit scandal.
Writers: Dick Clement, Ian La Frenais | Director: Roger Donaldson | Stars: Jason Statham, Saffron Burrows, Stephen Campbell Moore, Daniel Mays
Votes: 145,842
11. Daredevil (2003)
PG-13 | 103 min | Action, Crime, Fantasy
A man blinded by toxic waste which also enhanced his remaining senses fights crime as an acrobatic martial arts superhero.
Writer: Mark Steven Johnson | Director: Mark Steven Johnson | Stars: Ben Affleck, Jennifer Garner, Colin Farrell, Michael Clarke Duncan
Votes: 163,934
12. RocknRolla (2008)
R | 114 min | Action, Crime, Thriller
In London, a real-estate scam puts millions of pounds up for grabs, attracting some of the city's scrappiest tough guys and its more established underworld types, all of whom are looking to get rich quick. While the city's seasoned criminals vie for the cash, an unexpected player -- a drugged out rock 'n' roller presumed to be dead but very much alive -- has a multi-million dollar prize fall into... See full summary »
Writer: Guy Ritchie | Director: Guy Ritchie | Stars: Gerard Butler, Tom Wilkinson, Idris Elba, Thandie Newton
Votes: 181,625
13. Slumdog Millionaire (2008)
R | 120 min | Drama, Romance
A Mumbai teen, who grew up in the slums, becomes a contestant on the Indian version of "Who Wants To Be A Millionaire?" He is arrested under suspicion of cheating, and while being interrogated, events from his life history are shown which explain why he knows the answers.
Writers: Simon Beaufoy, Vikas Swarup | Directors: Danny Boyle, Loveleen Tandan | Stars: Dev Patel, Freida Pinto, Saurabh Shukla, Anil Kapoor
Votes: 593,609
14. Wanted (2008)
R | 110 min | Action, Crime, Fantasy
A frustrated office worker learns that he is the son of a professional assassin, and that he shares his father's superhuman killing abilities.
Writers: Michael Brandt, Derek Haas, Chris Morgan, Mark Millar, J.G. Jones | Director: Timur Bekmambetov | Stars: Angelina Jolie, James McAvoy, Morgan Freeman, Terence Stamp
Votes: 282,970
15. Drag Me to Hell (2009)
PG-13 | 99 min | Horror, Thriller
A loan officer who evicts an old woman from her home finds herself the recipient of a supernatural curse. Desperate, she turns to a seer to try and save her soul, while evil forces work to push her to a breaking point.
Writers: Sam Raimi, Ivan Raimi | Director: Sam Raimi | Stars: Alison Lohman, Justin Long, Ruth Livier, Lorna Raver
Votes: 148,473
16. Trance (I) (2013)
R | 101 min | Crime, Drama, Mystery
An art auctioneer who has become mixed up with a group of criminals partners with a hypnotherapist in order to recover a lost painting.
Writers: Joe Ahearne, John Hodge | Director: Danny Boyle | Stars: James McAvoy, Rosario Dawson, Vincent Cassel, Danny Sapani
Votes: 86,333
17. Push (2009)
PG-13 | 111 min | Action, Sci-Fi, Thriller
Two young Americans with special abilities must race to find a girl in Hong Kong before a shadowy government organization called Division does.
Writer: David Bourla | Director: Paul McGuigan | Stars: Camilla Belle, Dakota Fanning, Chris Evans, Colin Ford
Votes: 86,242
18. Do the Right Thing (1989)
R | 120 min | Drama
On the hottest day of the year on a street in the Bedford-Stuyvesant section of Brooklyn, everyone's hate and bigotry smolders and builds until it explodes into violence.
Writer: Spike Lee | Director: Spike Lee | Stars: Danny Aiello, Ossie Davis, Ruby Dee, Richard Edson
Votes: 55,163
19. A Perfect Getaway (2009)
R | 98 min | Adventure, Mystery, Thriller
Two pairs of lovers on a Hawaiian vacation discover that psychopaths are stalking and murdering tourists on the islands.
Writer: David Twohy | Director: David Twohy | Stars: Milla Jovovich, Steve Zahn, Timothy Olyphant, Kiele Sanchez
Votes: 53,697
20. Centurion (2010)
R | 97 min | Action, Adventure, Drama
A splinter group of Roman soldiers fight for their lives behind enemy lines after their legion is decimated in a devastating guerrilla attack.
Writer: Neil Marshall | Director: Neil Marshall | Stars: Michael Fassbender, Dominic West, Olga Kurylenko, Andreas Wisniewski
Votes: 60,767
21. Doubt (I) (2008)
PG-13 | 104 min | Drama, Mystery
A Catholic school principal questions a priest's ambiguous relationship with a troubled young student.
Writer: John Patrick Shanley | Director: John Patrick Shanley | Stars: Meryl Streep, Philip Seymour Hoffman, Amy Adams, Viola Davis
Votes: 94,227
22. The Runaways (2010)
R | 106 min | Biography, Drama, History
A coming-of-age biographical film about the 1970s teenage all-girl rock band The Runaways. This film also explores the relationship between band members Joan Jett and Cherie Currie.
Writers: Floria Sigismondi, Cherie Currie | Director: Floria Sigismondi | Stars: Kristen Stewart, Dakota Fanning, Michael Shannon, Stella Maeve
Votes: 37,279
23. A Serious Man (2009)
R | 106 min | Comedy, Drama
Larry Gopnik, a Midwestern physics teacher, watches his life unravel over multiple sudden incidents. Though seeking meaning and answers amidst his turmoils, he seems to keep sinking.
Writers: Joel Coen, Ethan Coen | Directors: Ethan Coen, Joel Coen | Stars: Michael Stuhlbarg, Richard Kind, Sari Lennick, Fred Melamed
Votes: 94,404
24. Carlito's Way (1993)
R | 144 min | Crime, Drama
A Puerto Rican former convict, just released from prison, pledges to stay away from drugs and violence despite the pressure around him and lead on to a better life outside of N.Y.C.
Writers: Edwin Torres, David Koepp | Director: Brian De Palma | Stars: Al Pacino, Sean Penn, Penelope Ann Miller, John Leguizamo
Votes: 154,050
25. Battlefield Earth (2000)
PG-13 | 118 min | Action, Adventure, Sci-Fi
After enslavement & near extermination by an alien race in the year 3000, humanity begins to fight back.
Writers: Corey Mandell, J.D. Shapiro, L. Ron Hubbard | Director: Roger Christian | Stars: John Travolta, Forest Whitaker, Barry Pepper, Kim Coates
Votes: 62,927
26. Revolver (2005)
R | 111 min | Action, Crime, Drama
Gambler Jake Green enters into a game with potentially deadly consequences.
Writers: Luc Besson, Guy Ritchie | Director: Guy Ritchie | Stars: Jason Statham, Ray Liotta, Vincent Pastore, André Benjamin
Votes: 69,800
PG-13 | 120 min | Drama, Sci-Fi
PROT is a patient at a mental hospital who claims to be from a far away Planet. His psychiatrist tries to help him, only to begin to doubt his own explanations.
Writers: Gene Brewer, Charles Leavitt | Director: Iain Softley | Stars: Kevin Spacey, Jeff Bridges, Mary McCormack, Alfre Woodard
Votes: 138,571
28. New Jack City (1991)
R | 97 min | Action, Crime, Drama
A crime lord ascends to power and becomes megalomaniacal while a maverick police detective vows to stop him.
Writers: Thomas Lee Wright, Barry Michael Cooper | Director: Mario Van Peebles | Stars: Wesley Snipes, Ice-T, Allen Payne, Chris Rock
Votes: 21,968
29. Batman: The Movie (1966)
PG | 105 min | Adventure, Comedy, Family
The Dynamic Duo faces four super-villains who plan to hold the world for ransom with the help of a secret invention that instantly dehydrates people.
Writers: Bob Kane, Lorenzo Semple Jr. | Director: Leslie H. Martinson | Stars: Adam West, Burt Ward, Lee Meriwether, Cesar Romero
Votes: 21,385
30. The Forgotten (2004)
PG-13 | 91 min | Drama, Horror, Mystery
After being told that their children never existed, a man and woman soon discover there is a much bigger enemy at work.
Writer: Gerald Di Pego | Director: Joseph Ruben | Stars: Julianne Moore, Dominic West, Christopher Kovaleski, Matthew Pleszewicz
Votes: 55,703
31. Forces of Nature (1999)
PG-13 | 105 min | Comedy, Romance
A soon-to-be-married man encounters an exciting stranger after his plane suffers an accident on takeoff.
Writer: Marc Lawrence | Director: Bronwen Hughes | Stars: Sandra Bullock, Ben Affleck, Maura Tierney, Steve Zahn
Votes: 25,375
32. The Next Best Thing (2000)
PG-13 | 108 min | Comedy, Drama, Romance
Abbie, tired of failed relationships, has a one-night-stand with her gay friend; they agree to raise the resulting baby together.
Writer: Tom Ropelewski | Director: John Schlesinger | Stars: Madonna, Rupert Everett, Benjamin Bratt, Illeana Douglas
Votes: 9,055
33. Tideland (2005)
R | 120 min | Drama, Fantasy
Because of the actions of her irresponsible parents, a young girl is left alone on a decrepit country estate and survives inside her fantastic imagination.
Writers: Tony Grisoni, Terry Gilliam, Mitch Cullin | Director: Terry Gilliam | Stars: Jeff Bridges, Jennifer Tilly, Jodelle Ferland, Janet McTeer
Votes: 25,623
34. Ichi the Killer (2001)
R | 129 min | Action, Comedy, Crime
As sadomasochistic yakuza enforcer Kakihara searches for his missing boss he comes across Ichi, a repressed and psychotic killer who may be able to inflict levels of pain that Kakihara has only dreamed of.
Writers: Hideo Yamamoto, Sakichi Satô | Director: Takashi Miike | Stars: Tadanobu Asano, Nao Ômori, Shin'ya Tsukamoto, Paulyn Sun
Votes: 40,584
35. Rang De Basanti (2006)
Not Rated | 157 min | Comedy, Drama, History
The story of six young Indians who assist an English Woman to film a documentary on the extremist freedom fighters from their past, and the events that lead them to relive the long forgotten saga of freedom.
Writers: Renzil D'Silva, Rakeysh Omprakash Mehra, Kamlesh Pandey | Director: Rakeysh Omprakash Mehra | Stars: Aamir Khan, Soha Ali Khan, Siddharth, Sharman Joshi
Votes: 61,919
36. Casualties of War (1989)
R | 113 min | Drama, History, War
During the Vietnam War, a soldier finds himself the outsider of his own squad when they unnecessarily kidnap a female villager.
Writers: Daniel Lang, David Rabe | Director: Brian De Palma | Stars: Michael J. Fox, Sean Penn, Don Harvey, John C. Reilly
Votes: 31,563
37. 2 Days in the Valley (1996)
R | 104 min | Comedy, Crime, Drama
48 hours of intersecting lives and crimes in Los Angeles.
Writer: John Herzfeld | Director: John Herzfeld | Stars: Teri Hatcher, Jeff Daniels, Danny Aiello, Charlize Theron
Votes: 15,081
38. The Order (2003)
R | 102 min | Action, Mystery, Thriller
A young priest is sent to Rome to investigate the troubling death of the head of his order.
Writer: Brian Helgeland | Director: Brian Helgeland | Stars: Heath Ledger, Mark Addy, Shannyn Sossamon, Benno Fürmann
Votes: 14,520
39. Wild Bill (1995)
R | 98 min | Action, Biography, Western
The early career of legendary lawman Wild Bill Hickock is telescoped and culminates in his relocation in Deadwood and a reunion with Calamity Jane.
Writers: Peter Dexter, Thomas Babe, Walter Hill | Director: Walter Hill | Stars: Jeff Bridges, Ellen Barkin, John Hurt, Diane Lane
Votes: 4,558
40. New York Stories (1989)
PG | 124 min | Comedy, Drama, Romance
A middle-aged artist obsessed with his pretty young assistant, a precocious 12 year old living in a hotel, and a neurotic lawyer with a possessive mother make up three Gotham tales.
Writers: Richard Price, Woody Allen, Francis Ford Coppola, Sofia Coppola | Directors: Woody Allen, Francis Ford Coppola, Martin Scorsese | Stars: Woody Allen, Nick Nolte, Rosanna Arquette, Marvin Chatinover
Votes: 12,919
41. War and Peace (1956)
PG | 208 min | Drama, Romance, War
Napoleon's tumultuous relations with Russia including his disastrous 1812 invasion serve as the backdrop for the tangled personal lives of two aristocratic families.
Writers: Leo Tolstoy, Bridget Boland, Robert Westerby, King Vidor, Mario Camerini, Ennio De Concini, Ivo Perilli | Director: King Vidor | Stars: Audrey Hepburn, Henry Fonda, Mel Ferrer, Vittorio Gassman
Votes: 6,367
42. Split Second (1992)
R | 90 min | Action, Crime, Horror
In a futuristic London, the rising sea levels mean that large areas are under feet of water. Hauer plays a cop who previously lost his partner to some strange creature. Now the creature is ... See full summary »
Writer: Gary Scott Thompson | Director: Tony Maylam | Stars: Rutger Hauer, Kim Cattrall, Alastair Duncan, Michael J. Pollard
Votes: 7,805
43. Vampire in Brooklyn (1995)
R | 100 min | Comedy, Fantasy, Horror
Maximillian is the only survivor from a race of vampires on a Caribbean Island, and as a vampire, he must find a mate to keep the line from ending. He knows that a child had been born to a ... See full summary »
Writers: Eddie Murphy, Vernon Lynch, Charlie Murphy, Michael Lucker, Chris Parker | Director: Wes Craven | Stars: Eddie Murphy, Angela Bassett, Allen Payne, Kadeem Hardison
Votes: 16,393
44. The Ipcress File (1965)
109 min | Crime, Thriller
In London, a counter espionage agent deals with his own bureaucracy while investigating the kidnapping and brainwashing of British scientists.
Writers: W.H. Canaway, James Doran | Director: Sidney J. Furie | Stars: Michael Caine, Nigel Green, Guy Doleman, Sue Lloyd
Votes: 9,331
45. Raising Cain (1992)
R | 91 min | Crime, Drama, Thriller
Jenny Nix, wife of eminent child psychologist Carter Nix, becomes increasingly concerned about her husband's seemingly obsessive concern over the upbringing of their daughter. Her own ... See full summary »
Writer: Brian De Palma | Director: Brian De Palma | Stars: John Lithgow, Lolita Davidovich, Steven Bauer, Frances Sternhagen
Votes: 9,361
46. The King of Fighters (2010)
93 min | Action, Sci-Fi, Thriller
Live-action feature based on the video game "King of Fighters".
Writers: Rita Augustine, Chris Chow, Matthew Ryan Fischer | Director: Gordon Chan | Stars: Maggie Q, Sean Faris, Will Yun Lee, Ray Park
Votes: 3,470
47. End Game (2006)
R | 93 min | Action, Crime, Drama
A secret Service agent and a news reporter investigate the conspiracy behind the assassination of the President.
Writers: J.C. Pollock, Andy Cheng | Director: Andy Cheng | Stars: Cuba Gooding Jr., Angie Harmon, James Woods, Patrick Fabian
Votes: 4,321
48. Compulsion (1959)
Approved | 103 min | Biography, Crime, Drama
Two wealthy law-school students go on trial for murder in this version of the Leopold-Loeb case.
Writers: Richard Murphy, Meyer Levin | Director: Richard Fleischer | Stars: Orson Welles, Dean Stockwell, Diane Varsi, Bradford Dillman
Votes: 3,552
49. Nick Fury: Agent of Shield (1998 TV Movie)
Unrated | 120 min | Action, Sci-Fi
Marvel's hard-boiled hero is brought to TV. He is brought back to fight the menace of Hydra after exiling himself in the Yukon since the end of the Cold War. The children of the former ... See full summary »
Writer: David S. Goyer | Director: Rod Hardy | Stars: David Hasselhoff, Lisa Rinna, Sandra Hess, Neil Roberts
Votes: 1,974
50. Ashes of Time (1994)
R | 100 min | Action, Drama
A broken-hearted hit man moves to the desert where he finds skilled swordsmen to carry out his contract killings.
Writers: Louis Cha, Kar Wai Wong | Director: Kar Wai Wong | Stars: Brigitte Lin, Maggie Cheung, Leslie Cheung, Tony Chiu Wai Leung
Votes: 9,546


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The OHSU Student Center stocks a limited selection of medical reference books, medical equipment, logo merchandise and stationary items and is your departmental and individual resource for special orders. If you're on campus, most items from the online apparel and gifts store are also available at the Student Center Campus Store (unless specifically noted). The Campus Store is located on the Campus Drive curve between Doernbecher Children's Hospital and Hatfield Research Center. Come see us!
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Resolution: standard / high
Figure 9.
eQTL Linkage Precision-Recall; 300 Samples. Precision and recall of transcript-locus linkages for 300 experiments. At the precision level of 0.8, the SCT method achieves a recall of 0.735, versus 0.590, 0.25 and 0.08 for the LCMS, Basic and univariate mapping methods, respectively.
Chipman and Singh BMC Bioinformatics 2011 12:7 doi:10.1186/1471-2105-12-7


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Purine-scaffold Hsp90 inhibitors
ABSTRACT Heat shock protein 90 (Hsp90) has emerged as an important target, the inhibition of which is aimed at a wide range of cell transformations that lead to malignancy. A clinical evaluation of 17-AAG, the first Hsp90 inhibitor to enter the clinic, revealed evidence of activity for the compound at a manageable level of toxicity. However, clinical results have also demonstrated the limitations of this drug. The identification of novel Hsp90 inhibitor classes with improved structural characteristics and better pharmacological profiles has therefore become a major focus of interest in the field of cancer therapeutics. This feature describes the purine-scaffold class of Hsp90 inhibitors, focusing on research efforts from the discovery stage to the clinical translation of such compounds.
- References (0)
- Cited In (16)
- SourceAvailable from: Darius Ebrahimi-Fakhari
- "Hsp90 negatively regulates Hsp70 expression by blocking activation of the transcription factor HSF-1; thus inhibitors result in Hsp70 induction [15]. Geldanamycin is a naturally occurring benzoquinone that blocks Hsp90 interaction with HSF-1 resulting in enhanced Hsp70 expression [16]. However, its utility is limited by hepatotoxicity and poor brain permeability. "
Article: Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss[Show abstract] [Hide abstract]
ABSTRACT: Hsp90 inhibitors such as geldanamycin potently induce Hsp70 and reduce cytotoxicity due to α-synuclein expression, although their use has been limited due to toxicity, brain permeability, and drug design. We recently described the effects of a novel class of potent, small molecule Hsp90 inhibitors in cells overexpressing α-synuclein. Screening yielded several candidate compounds that significantly reduced α-synuclein oligomer formation and cytotoxicity associated with Hsp70 induction. In this study we examined whether chronic treatment with candidate Hsp90 inhibitors could protect against α-synuclein toxicity in a rat model of parkinsonism. Rats were injected unilaterally in the substantia nigra with AAV8 expressing human α-synuclein and then treated with drug for approximately 8 weeks by oral gavage. Chronic treatment with SNX-0723 or the more potent, SNX-9114 failed to reduce dopaminergic toxicity in the substantia nigra compared to vehicle. However, SNX-9114 significantly increased striatal dopamine content suggesting a positive neuromodulatory effect on striatal terminals. Treatment was generally well tolerated, but higher dose SNX-0723 (6-10 mg/kg) resulted in systemic toxicity, weight loss, and early death. Although still limited by potential toxicity, Hsp90 inhibitors tested herein demonstrate oral efficacy and possible beneficial effects on dopamine production in a vertebrate model of parkinsonism that warrant further study.PLoS ONE 01/2014; 9(1):e86048. DOI:10.1371/journal.pone.0086048 · 3.23 Impact Factor
[Show abstract] [Hide abstract]
- "However, structurally related compounds to GA, including 17-(allylamino)-17-demethoxygeldanamycin (17-AAG), were found to be suboptimal and Therapeutic Advances in Neurological Disorders 7 (1) 44 http://tan.sagepub.com human clinical trials in the cancer field presented with varying problems including drug-induced liver injury [Waza et al. 2006] (discussed elsewhere [Chiosis and Tao, 2006]). In light of this, a group of chemically dissimilar Hsp90-inhibiting compounds was screened; the compounds belong to the SNX-2112 drug class which was found to be a promising alternative in the cancer field [Chandarlapaty et al. 2008; Okawa et al. 2009]. "
ABSTRACT: Parkinson's disease is a slowly progressive neurodegenerative disorder typically characterized by the loss of dopaminergic neurons within the substantia nigra pars compacta, and the intraneuronal deposition of insoluble protein aggregates chiefly comprised of α-synuclein. Patients experience debilitating symptoms including bradykinesia, rigidity and postural instability. No curative treatment currently exists and therapeutic strategies are restricted to symptomatic treatment only. Over the past decade a class of molecular chaperones called the heat shock proteins has emerged as a potentially promising therapeutic target. Heat shock proteins aid in the folding and refolding of proteins, and target denatured proteins to degradation systems. By targeting heat shock proteins through various means including overexpression and pharmacological enhancement, researchers have shown that α-synuclein aggregation and its associated cytotoxicity can be therapeutically modulated in an array of cell and animal models. This review highlights the relevant progress in this field and discusses the relevance of heat shock proteins as therapeutic modulators of α-synuclein toxicity to the rapidly evolving understanding of Parkinson's disease pathogenesis.Therapeutic Advances in Neurological Disorders 01/2014; 7(1):33-51. DOI:10.1177/1756285613493469 · 3.14 Impact Factor
- "HSP-90 inhibitors, such as 17-AAG and radicicol, have similar neuroprotective effects as those of HSF-1 and HSP-70 up-regulation [58,59]. The blood-brain barrier permeability presents a limitation [60,61]. 17-AAG is currently in phase II trials as an antitumor compound [62,63], showing neuroprotective effects in preclinical models of Huntington's disease and spinocerebellar ataxias [57,59]. "
Article: White Matter Loss in a Mouse Model of Periventricular Leukomalacia Is Rescued by Trophic Factors[Show abstract] [Hide abstract]
ABSTRACT: Periventricular leukomalacia (PVL) is the most frequent cause of cerebral palsy and other intellectual disabilities, and currently there is no treatment. In PVL, glutamate excitotoxicity (GME) leads to abnormal oligodendrocytes (OLs), myelin deficiency, and ventriculomegaly. We have previously identified that the combination of transferrin and insulin growth factors (TSC1) promotes endogenous OL regeneration and remyelination in the postnatal and adult rodent brain. Here, we produced a periventricular white matter lesion with a single intracerebral injection of N-methyl-d-aspartate (NMDA). Comparing lesions produced by NMDA alone and those produced by NMDA + TSC1 we found that: NMDA affected survival and reduced migration of OL progenitors (OLPs). In contrast, mice injected with NMDA + TSC1 proliferated twice as much indicating that TSC1 supported regeneration of the OLP population after the insult. Olig2-mRNA expression showed 52% OLP survival in mice receiving a NMDA injection and increased to 78% when TSC1 + NMDA were injected simultaneously and ventricular size was reduced by TSC1. Furthermore, in striatal slices TSC1 reduced the inward currents induced by NMDA in medium-sized spiny neurons, demonstrating neuroprotection. Thus, white matter loss after excitotoxicity can be partially rescued as TSC1 conferred neuroprotection to preexisting OLP and regeneration via OLP proliferation. Furthermore, we showed that early TSC1 administration maximizes neuroprotection.12/2013; 3(4):1461-82. DOI:10.3390/brainsci3041461


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Spring Tornadoes Are an Important Reminder to Prepare
News Source : Spring Tornadoes Are an Important Reminder to Prepare
DENVER – A year ago Tuesday, on May 20, an EF5 tornado struck Moore, Oklahoma, killing 24 and leaving a 17-mile trail of destruction.
A month later, June 20, will be the anniversary of the 1957 EF5 tornado in Fargo that killed 10 and was part of a family of five tornadoes that wreaked havoc for almost 70 miles, from Buffalo, North Dakota, to Dale, Minnesota. The tornado and its damage were studied extensively by T. Theodore Fujita of the University of Chicago, which led to his later development of the 1-5 F-Scale for ranking tornadoes. (The Fargo tornado was ranked in retrospect.)
Both anniversaries are a poignant reminder of the importance of preparing for tornadoes, point out emergency managers from the North Dakota Division of Emergency Management and from the Federal Emergency Management Agency (FEMA). North Dakota gets an average of 23 reported tornadoes per year, mostly in June, July and August.
The state's website (http://www.nd.gov/des/uploads/resources/150/tornadotips.pdf) provides these suggestions for what to do during a tornado:
- In a house with a basement: Avoid windows. Get in the basement and under some kind of sturdy protection (heavy table or work bench), or cover yourself with a mattress or sleeping bag. Know where very heavy objects rest on the floor above (pianos, refrigerators, waterbeds, etc.) and do not go under them. They may fall down through a weakened floor and crush you.
- In a house with no basement, a dorm, or an apartment: Avoid windows. Go to the lowest floor, small center room (like a bathroom or closet), under a stairwell, or in an interior hallway with no windows. Crouch as low as possible to the floor, facing down, and cover your head with your hands. A bath tub may offer a shell of partial protection. Even in an interior room, you should cover yourself with some sort of thick padding (mattress, blankets, etc.), to protect against falling debris in case the roof and ceiling fail.
- In an office building, hospital, or nursing home: Go directly to an enclosed, windowless area in the center of the building -- away from glass. Crouch down and cover your head. Interior stairwells are usually good places to take shelter, and if not crowded, allow you to get to a lower level quickly. Stay off the elevators; you could be trapped in them if the power is lost.
- In a mobile home: Get out! Even if your home is tied down, you are probably safer outside, even if the only alternative is to seek shelter out in the open. Most tornadoes can destroy even tied-down mobile homes; and it is best not to play the low odds that yours will make it. If there is a sturdy permanent building within easy running distance, seek shelter there. Otherwise, lie flat on low ground away from your home, protecting your head. If possible, use open ground away from trees and cars, which can be blown onto you. The only fatality in the Northwood tornado remained in his home.
- At school: Follow the drill! Go to the interior hall or room in an orderly way as you are told. Crouch low, head down, and protect the back of your head with your arms. Stay away from windows and large open rooms like gyms and auditoriums.
- In a car or truck: Vehicles are extremely dangerous in a tornado. If the tornado is visible, far away, and the traffic is light, you may be able to drive out of its path by moving at right angles to the tornado. Otherwise, park the car as quickly and safely as possible -- out of the traffic lanes. Get out and seek shelter in a sturdy building. If in the open country, run to low ground away from any cars which could roll over onto you. Lie flat and face-down, protecting the back of your head with your arms. Avoid seeking shelter under bridges, which can create deadly traffic hazards while offering little protection against flying debris.
- Outside: If possible, seek shelter in a sturdy building. If not, lie flat and face-down on low ground, protecting the back of your head with your arms. Get as far away from trees and cars as you can.
- In a shopping mall or large store: Do not panic. Watch for others. Move as quickly as possible to an interior bathroom, storage room or other small enclosed area, away from windows.
- In a church or theater: Do not panic. If possible, move quickly but orderly to an interior bathroom or hallway, away from windows. Crouch face-down and protect your head with your arms. If there is no time to do that, get under the seats or pews, protecting your head with your arms or hands.
Research shows that most people wait until bad news is confirmed by a second source before taking action. With tornadoes, act first, emergency officials warn. Take shelter yourself, then be the second source that confirms the emergency for others by phone or social media.
FEMA's Ready.gov website cites a study of tornado damage in Marion, Illinois, that showed half of all tornado-related injuries came after the tornado, from rescue attempts, clean up, and so forth. Almost a third of the injuries came from stepping on nails. Be very careful when entering any damaged structure, and use battery-powered light if possible rather than candles to minimize the danger of fire or explosions.
A timeline of some of the most significant tornadoes to affect the six-state region covered by FEMA's Denver regional office, with links for more information, is available at http://www.fema.gov/fema-region-8-tornado-timeline.
FEMA's mission is to support our citizens and first responders to ensure that as a nation we work together to build, sustain, and improve our capability to prepare for, protect against, respond to, recover from, and mitigate all hazards.
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High Quality Construction with large parking area and loading dock for the space. There are several small offices in the front of the space and the warehouse storage has clear span of approximately 18 feet. Great Landlord who is the onsite property manager for the well maintained and efficient property. The NNN is currently $1.45/sf +/-.
Great Location in West Wareham just off Route 28 and very close to the intersection of I-495 and I-195. Easy access to the highways and Cape Cod, the SouthCoast, Providence, and Boston. Ammenities nearby include Wareham Crossing a regional retail center with Lowe's and Target and many small stores and restaurants. Owner has 9 buildings in this market with several sizes of space available allowing room for future growth.
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Company Overview of Terra Firma Capital Partners Limited
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Mr. Robert Nicolas Barr, also known as Robbie, serves as the Operational Managing Director of Terra Firma Capital Partners Limited. Mr. Barr served as the Chief Operating Officer at Terra Firma Capital Partners, which he joined in 2009. Mr. Barr served as the Group Financial Controller of Vodafone Group Plc. since 1993 and served as its Regional Chief Financial Officer of Vodafone's businesses outside Western Europe. Mr. Barr served as the UK Financial Controller of ...
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Jews have little problem with Prime Minister David Cameron defining Britain as a Christian country despite an outcry from some secularists.
In a pre-Easter article, Mr Cameron said that Britain should be more confident about its Christian status and that its religious character made it easier for Jews and Muslims to live here than in a secular society.
An Iraqi-Muslim academic today described a meeting of religious leaders from Israel, Iran and Iraq as "a really special event".
The religious leaders flew to the UK in a groundbreaking bid to forge ties and resolve the ongoing crisis in the Middle East.
A Christian group has hit back at the London church which erected a controversial replica of the Israeli security wall in its grounds.
Organisers of the "Bethlehem Unwrapped" festival at St James's Church in Piccadilly said the wall had been built to highlight Israeli treatment of Palestinian Christians.
After the £30,000 replica wall of Bethlehem came down in the courtyard of St James's Church Piccadilly, just before the Quakers sent their 12th year of Ecumenical Accompaniers into Palestinian villages at a cost of over £5,000 per observer, and right around the time that the Methodist Church engaged a cadre of its leading ministers and its top staffer on poverty and justice, for months of con
The Pope is to travel to Israel in May for his first visit since becoming Pontiff.
Francis I announced his plans during his Sunday address to thousands of Catholics gathered in St Peter's Square.
Further details announced by the Vatican revealed that the trip to the Holy Land would be the Pope's first overseas tour of the year.
The chief rabbi has joined Prince Charles in voicing grave concern over the persecution of Christian communities Middle East countries.
The Prince told a gathering of religious leaders in London this week that the situation had reached "crisis point".
Doing anything special on December 25? Christmas is a polarising time for UK Jews. Some enter enthusiastically into a secular celebration, sitting down with family and friends to a (kosher) turkey dinner, handing out presents and pulling crackers. Others get into the spirit of the season of goodwill by volunteering at a variety of charities.
The melt-down at the Co-operative Bank should not have come as a huge surprise to JC readers.
But serious allegations against the bank's former chairman, Reverend Paul Flowers, have come as a shock.
His alleged drug-use has disgraced the Co-op Bank and led to his suspension from the Methodist Church and the Labour Party, where until recently he was a respected councillor.
Faith and Communities Minister Baroness Warsi has called on people of all religions to do more to tackle hatred and end persecution.
Speaking at Georgetown University in Washington DC, she said sectarianism was becoming the leading reason for conflict in the world, with "faith forming the fault lines" under a "global crisis".
A blood libel in which Jews were falsely accused of killing a young Christian girl and using her blood in a religious ritual in 19th century Hungary is the basis for a new opera opening this weekend in Budapest.
The Red Heifer is based on a true story set in the Hungarian village of Tiszaeszlár, where 14-year-old Eszter Solymosi disappeared in 1882.


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The total solar eclipse happened at 0638 AEST (2038 GMT) and it cast a shadow over a 90 mile-wide area of Australia.
It is the first total solar eclipse in Australia for a decade.
A total solar eclipse occurs when the moon completely obscures the sun and it appears dark for about two minutes.
Up to 60,000 people were reportedly expected to watch the eclipse in Cairns.
Eclipse watchers were advised to wear safety glasses or to use cardboard projection devices to sheild the sun's rays from onlookers' eyes.
Contains video from APTN


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|By Karin Wilson
Article Rating:
|January 8, 2013 08:00 AM EST
Businesses live and die by their ability to sell. When it comes to cloud computing, this is no different. The benefits associated with selling in the cloud are shorter time to market, revenue streams that don't tend to fluctuate, and a shortened sales cycle. Despite common belief, the key to successful selling in the cloud doesn't rely on the technology infrastructure behind the scenes -- the real key is in billing.
Monetizing the Agreement
In essence, a cloud solution is an agreement between the vendor and the user. The ability to monetize that agreement is the heart of how to sell in the cloud. The more customers using your solution, the more revenue you create. To ensure a steady and predictable revenue stream the back end systems need to be able to support it.
Function Before Form
The temptation with any sales process is to sell the sizzle; however, in a cloud environment, function is what's important. Simplicity is key - from account creation to managing payment processes, billing, and user management, making these processes as simple as possible will make signing up new customers much easier.
Having a customer relationship management process in place will also allow for easier access to things like entitlements and product updates; and it will make the procedure to cross sell easier because a CRM solution allows a business to target a perfect niche user, based on their previous habits.
Using the cloud in the sales process allows for a level of scalability that businesses did not have before. The ability to ramp up selling historically was tied to staffing; now it's simply a matter of production vs demand. Ensure that your cloud solution provides the necessary level of scalability so that you are prepared for future growth.
Service Before Sales
At its core sales is about service, and providing the customer with what they need. While a cloud provider may have all the bells and whistles and be able to charm you with the latest technology buzzwords, fulfilling the basic function of satisfying the customer is at the heart of selling, whether it be in the cloud or in person.
Focus on the fundamentals of making it easy for the customer to buy. By giving the best service possible before and after the sale, selling in the cloud will be one of the most profitable and predictable revenue sources your business can leverage.
Research for this post was provided by Rand Group, an ERP software solution provider in Houston, Texas.
"Matrix is an ambitious open standard and implementation that's set up to break down the fragmentation problems that exist in IP messaging and VoIP communication," explained John Woolf, Technical Evangelist at Matrix, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Oct. 13, 2015 07:00 AM EDT Reads: 6,009
As more intelligent IoT applications shift into gear, they're merging into the ever-increasing traffic flow of the Internet. It won't be long before we experience bottlenecks, as IoT traffic peaks during rush hours. Organizations that are unprepared will find themselves by the side of the road unable to cross back into the fast lane. As billions of new devices begin to communicate and exchange data – will your infrastructure be scalable enough to handle this new interconnected world?
Oct. 13, 2015 05:45 AM EDT
SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in high-performance, high-efficiency server, storage technology and green computing, will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/Big Data, HPC and Embedded Systems worldwide. Supermi...
Oct. 13, 2015 05:15 AM EDT Reads: 198
Nowadays, a large number of sensors and devices are connected to the network. Leading-edge IoT technologies integrate various types of sensor data to create a new value for several business decision scenarios. The transparent cloud is a model of a new IoT emergence service platform. Many service providers store and access various types of sensor data in order to create and find out new business values by integrating such data.
Oct. 13, 2015 04:00 AM EDT Reads: 684
There are so many tools and techniques for data analytics that even for a data scientist the choices, possible systems, and even the types of data can be daunting. In his session at @ThingsExpo, Chris Harrold, Global CTO for Big Data Solutions for EMC Corporation, will show how to perform a simple, but meaningful analysis of social sentiment data using freely available tools that take only minutes to download and install. Participants will get the download information, scripts, and complete end-to-end walkthrough of the analysis from start to finish. Participants will also be given the pract...
Oct. 13, 2015 03:00 AM EDT Reads: 408
Too often with compelling new technologies market participants become overly enamored with that attractiveness of the technology and neglect underlying business drivers. This tendency, what some call the "newest shiny object syndrome," is understandable given that virtually all of us are heavily engaged in technology. But it is also mistaken. Without concrete business cases driving its deployment, IoT, like many other technologies before it, will fade into obscurity.
Oct. 13, 2015 03:00 AM EDT Reads: 261
WebRTC services have already permeated corporate communications in the form of videoconferencing solutions. However, WebRTC has the potential of going beyond and catalyzing a new class of services providing more than calls with capabilities such as mass-scale real-time media broadcasting, enriched and augmented video, person-to-machine and machine-to-machine communications. In his session at @ThingsExpo, Luis Lopez, CEO of Kurento, will introduce the technologies required for implementing these ideas and some early experiments performed in the Kurento open source software community in areas ...
Oct. 13, 2015 12:45 AM EDT Reads: 854
Electric power utilities face relentless pressure on their financial performance, and reducing distribution grid losses is one of the last untapped opportunities to meet their business goals. Combining IoT-enabled sensors and cloud-based data analytics, utilities now are able to find, quantify and reduce losses faster – and with a smaller IT footprint. Solutions exist using Internet-enabled sensors deployed temporarily at strategic locations within the distribution grid to measure actual line loads.
Oct. 13, 2015 12:00 AM EDT Reads: 276
"In the past year we've seen a lot of stabilization of WebRTC. You can now use it in production with a far greater degree of certainty. A lot of the real developments in the past year have been in things like the data channel, which will enable a whole new type of application," explained Peter Dunkley, Technical Director at Acision, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Oct. 12, 2015 11:15 PM EDT Reads: 7,127
The Internet of Everything is re-shaping technology trends–moving away from "request/response" architecture to an "always-on" Streaming Web where data is in constant motion and secure, reliable communication is an absolute necessity. As more and more THINGS go online, the challenges that developers will need to address will only increase exponentially. In his session at @ThingsExpo, Todd Greene, Founder & CEO of PubNub, will explore the current state of IoT connectivity and review key trends and technology requirements that will drive the Internet of Things from hype to reality.
Oct. 12, 2015 10:15 PM EDT Reads: 316
There will be 20 billion IoT devices connected to the Internet soon. What if we could control these devices with our voice, mind, or gestures? What if we could teach these devices how to talk to each other? What if these devices could learn how to interact with us (and each other) to make our lives better? What if Jarvis was real? How can I gain these super powers? In his session at 17th Cloud Expo, Chris Matthieu, co-founder and CTO of Octoblu, will show you!
Oct. 12, 2015 08:45 PM EDT Reads: 276
Today's connected world is moving from devices towards things, what this means is that by using increasingly low cost sensors embedded in devices we can create many new use cases. These span across use cases in cities, vehicles, home, offices, factories, retail environments, worksites, health, logistics, and health. These use cases rely on ubiquitous connectivity and generate massive amounts of data at scale. These technologies enable new business opportunities, ways to optimize and automate, along with new ways to engage with users.
Oct. 12, 2015 06:00 PM EDT Reads: 265
Through WebRTC, audio and video communications are being embedded more easily than ever into applications, helping carriers, enterprises and independent software vendors deliver greater functionality to their end users. With today's business world increasingly focused on outcomes, users' growing calls for ease of use, and businesses craving smarter, tighter integration, what's the next step in delivering a richer, more immersive experience? That richer, more fully integrated experience comes about through a Communications Platform as a Service which allows for messaging, screen sharing, video...
Oct. 12, 2015 05:30 PM EDT Reads: 1,230
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo in Silicon Valley. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place Nov 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 17th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal an...
Oct. 12, 2015 04:30 PM EDT Reads: 198
SYS-CON Events announced today that Sandy Carter, IBM General Manager Cloud Ecosystem and Developers, and a Social Business Evangelist, will keynote at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA.
Oct. 12, 2015 03:00 PM EDT Reads: 248
WebRTC converts the entire network into a ubiquitous communications cloud thereby connecting anytime, anywhere through any point. In his session at WebRTC Summit,, Mark Castleman, EIR at Bell Labs and Head of Future X Labs, will discuss how the transformational nature of communications is achieved through the democratizing force of WebRTC. WebRTC is doing for voice what HTML did for web content.
Oct. 12, 2015 03:00 PM EDT Reads: 1,489
As a company adopts a DevOps approach to software development, what are key things that both the Dev and Ops side of the business must keep in mind to ensure effective continuous delivery? In his session at DevOps Summit, Mark Hydar, Head of DevOps, Ericsson TV Platforms, will share best practices and provide helpful tips for Ops teams to adopt an open line of communication with the development side of the house to ensure success between the two sides.
Oct. 12, 2015 01:00 PM EDT Reads: 695
The Internet of Things (IoT) is growing rapidly by extending current technologies, products and networks. By 2020, Cisco estimates there will be 50 billion connected devices. Gartner has forecast revenues of over $300 billion, just to IoT suppliers. Now is the time to figure out how you'll make money – not just create innovative products. With hundreds of new products and companies jumping into the IoT fray every month, there's no shortage of innovation. Despite this, McKinsey/VisionMobile data shows "less than 10 percent of IoT developers are making enough to support a reasonably sized team....
Oct. 12, 2015 01:00 PM EDT Reads: 340
The IoT market is on track to hit $7.1 trillion in 2020. The reality is that only a handful of companies are ready for this massive demand. There are a lot of barriers, paint points, traps, and hidden roadblocks. How can we deal with these issues and challenges? The paradigm has changed. Old-style ad-hoc trial-and-error ways will certainly lead you to the dead end. What is mandatory is an overarching and adaptive approach to effectively handle the rapid changes and exponential growth.
Oct. 12, 2015 12:00 PM EDT Reads: 335
Today air travel is a minefield of delays, hassles and customer disappointment. Airlines struggle to revitalize the experience. GE and M2Mi will demonstrate practical examples of how IoT solutions are helping airlines bring back personalization, reduce trip time and improve reliability. In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect with GE, and Dr. Sarah Cooper, M2Mi's VP Business Development and Engineering, will explore the IoT cloud-based platform technologies driving this change including privacy controls, data transparency and integration of real time context w...
Oct. 12, 2015 12:00 PM EDT Reads: 299


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More information here: http://blog.openhelix.eu/?p=5103 This is today's tip of the week introducing Brenda and how to get enzyme data from IDs and more.
Dr. Michael Olivier, Director of the Wisconsin Center of Excellence in Genomics Science, and Professor of Physiology at the Medical College of Wisconsin describes this NIH-funded center and its research focus on developing new technology in mass spectrometry and proteomics.
cancer gene identification
Biological network alignment.
This is two posters given together relating to molecular visualization.
Protein functional prediction
Advanced tips on using SEQUEST and TPP by Jimmy Eng of U. of Washington, the co-inventor of SEQUEST


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|Blog Posts
Oral Health America issued a startling report that reveals a sizeable disparity in the available of dental care for older Americans. "State of Decay" found a persistent lack of oral health coverage across much of the nation: 42% of states (21 states) provide either no dental benefits or provide only emergency coverage through adult Medicaid Dental benefits. A strained dental health work force prevails, with 31 states having high rates of Dental Health Provider Shortage Areas (HPSAs), meeting only 40% or less of dental provider needs. Tooth loss remains a signal of suboptimal oral health, with 8 states having strikingly high rates of edentulism (people with no teeth at all). By issuing this Report, Oral Health America aims to encourage better approaches to meet the oral health challenges among older adults – who experience the medical complexities of having multiple chronic diseases and often face financial challenges in paying for dental services.
A State of Decay. Oral Health America, October 2013.
Found abundantly in berries, polyphenols, an antioxidant compound, may reduce the risk of death.
Moderate exercise helps to reduce the risks of low back pain, among people who are overweight/obese.
Sleeping less than 5 hours a day, as well as 9 or more hours a day, associates with poor physical and mental health.
International Osteoporosis Foundation urges for immediate action to safeguard the quality of life among postmenopausal women.
Blood pressure is effectively lowered by mindfulness-based stress reduction, a technique combining meditation and yoga.
With only 2% of retired Americans having dental insurance, Oral Health America warns of an impending epidemic of poor periodontal health among older Americans.
Biotech-based detection of pathogenic microorganisms can cut the diagnostic time by two-thirds.
The condition that causes a clouding of the eye's lens is an under-recognized cause of the loss of the ability to live independently.
Daily supplementation with Bifidobacterium, a probiotic, may help to reduce the risk of the common cold, among active adults.
The swelling aging population may accelerate the financial costs of dementia to surpass those of heart disease and cancer.
The number of obese adults, related disease rates and health care costs, are on course to increase dramatically in the United States over the next 20 years.
Rush University (US) researcher reports that nearly 500,000 deaths in 2007 are attributable to the condition, factoring in chronic coexisting conditions.
Experts project that the incidence of diabetes is set to soar by 64% by 2025, meaning that a staggering 53.1 million citizens will be affected by the disease.
Much of the cancer burden in the US could be reduced via reduced tobacco use, improved diet, more exercise, weight loss, and screening tests.
More than 6% of Americans ages 70 to 89 develop mild cognitive impairment (MCI) every year, and the condition appears to affect men more than women.
Life expectancy for patients with Parkinson's disease is poorer than some previous studies have suggested, with barely one-third of patients surviving six years
A study examining the changes in cancer survival over the past 40 years has revealed that the difference in mortality between the married and never married, par
Researchers estimate that the number of cancer survivors aged 65 and over will increase by approximately 42% by 2020.
If the current "obesity epidemic" continues unchecked, 50% of the US adult population will be obese -- with body mass index values of 30 or higher -- by 2030.
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CARACAS Venezuela's cancer-stricken president, Hugo Chavez, is still suffering respiratory problems after surgery in Cuba two months ago, the government said on Thursday in a somber first communique since his homecoming this week.
Struggling to talk and breathing through a tracheal tube, the 58-year-old socialist leader is being treated at a Caracas military hospital after returning unseen before dawn on Monday.
Long accustomed to the drama and speculation over Chavez's health since cancer was first detected in June 2011, Venezuelans are now debating if he can recover and return to active rule, or may resign and try to ensure his vice president wins a vote.
Some think he may have simply come home to die.
"The breathing insufficiency that emerged post-operation persists, and the tendency has not been favorable, so it is still being treated," read the communique, in gloomy news for Chavez's millions of passionate supporters.
The short statement, read by Information Minister Ernesto Villegas, said, however, that treatment for Chavez's "base illness" - presumably the cancer first diagnosed in his pelvic area - continued without "significant adverse effects for now."
Little detailed medical information has been made public on Chavez's condition, meaning the government's occasional short statements are pored over by Venezuelans for clues about the future for him and the nation he has dominated since 1999.
Chavez is believed to be seeing only close family at the hospital and a few senior officials, including Vice President Nicolas Maduro and National Assembly head Diosdado Cabello.
"The patient remains in communication with relatives and the government political group in close collaboration with the medical team," the statement added.
"The president holds firm to Christ, with absolute will to live and maximum discipline in the treatment of his health."
Apart from a few photos of him lying in a Havana hospital bed that were released by the government last week, Chavez has not been seen or heard from in public since his December 11 operation, his fourth surgery for cancer in just 18 months.
He returned home at 2:30 a.m. local time (0700 GMT) on Monday without any of the fanfare or media attention that accompanied previous homecomings after treatment in Cuba.
A source at the military hospital said there was tight security surrounding Chavez's ninth-floor suite, and that the only doctors treating the president there were Cubans.
Staircases were sealed off with bars, the source said, and the area was covered by armed patrols and surveillance cameras.
Chavez originally chose to be treated in Cuba - where he has spent more than five months in total since mid-2011 - due to his friendship with leaders Fidel and Raul Castro, plus the discretion guaranteed on the tightly controlled island.
But in recent weeks, officials said, he had been pining to come home and listening to music from the his boyhood home in the "llanos" or plains in central Venezuela.
Vigils are being held across the nation, while politicians are quietly gearing up for a possible new presidential election.
Should Chavez leave power, a vote would have to be held within 30 days. His No. 2, Maduro, would likely run against opposition leader and state governor Henrique Capriles, who lost to Chavez in last year's presidential election. (Editing by Daniel Wallis and Peter Cooney)
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Pope Francis and a line-up of anti-nuclear campaigners headed lists of favourites to win the 2015 Nobel Peace Prize on the eve of Friday's announcement. Full Article
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