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Publications (68)574.81 Total impact
- International Journal of Epidemiology 07/2015; DOI:10.1093/ije/dyv118 · 9.18 Impact Factor
Article: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis[Show abstract] [Hide abstract]
ABSTRACT: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.BMC Medicine 07/2015; 13(1):156. DOI:10.1186/s12916-015-0392-6 · 7.25 Impact Factor
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ABSTRACT: This is the author accepted manuscript. It is currently under an indefinite embargo pending publication of the final version.
Article: Abstract P3-02-03: Breast cancer screening by women from BRCA1 & BRCA2 mutation positive families:Cancer Research 05/2015; 75(9 Supplement):P3-02-03-P3-02-03. DOI:10.1158/1538-7445.SABCS14-P3-02-03 · 9.33 Impact Factor
Article: Abstract P1-12-06: Co-SOFT: The cognitive function substudy of the suppression of ovarian function trial (SOFT)Cancer Research 05/2015; 75(9 Supplement):P1-12-06-P1-12-06. DOI:10.1158/1538-7445.SABCS14-P1-12-06 · 9.33 Impact Factor
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ABSTRACT: Objective: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods: Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results: We found no association with risk of ovarian cancer (OR=0.99, 95% CI 0.94-1.04, p=0.74) or breast cancer (OR=0.98, 95% CI 0.94-1.01, p=0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR=1.09, 95% CI 0.97-1.23, p=0.14, breast cancer HR=1.04, 95% CI 0.97-1.12, p=0.27; BRCA2, ovarian cancer HR=0.89, 95% CI 0.71-1.13, p=0.34, breast cancer HR=1.06, 95% CI 0.94-1.19, p=0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR=0.94, 95% CI 0.83-1.07, p=0.38), breast cancer (HR=0.96, 95% CI 0.87-1.06, p=0.38), and all other previously-reported associations. Conclusions: rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.Gynecologic Oncology 05/2015; DOI:10.1016/j.ygyno.2015.04.034 · 3.77 Impact Factor
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ABSTRACT: Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. Results: Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. Conclusions: Although no variants reached genome-wide significance (P <5 x 10(-8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.Breast Cancer Research 04/2015; 17(1). DOI:10.1186/s13058-015-0570-7 · 5.49 Impact Factor
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ABSTRACT: Background: Ovarian failure is a common toxic effect of chemotherapy. Studies of the use of gonadotropin-releasing hormone (GnRH) agonists to protect ovarian function have shown mixed results and lack data on pregnancy outcomes. Methods: We randomly assigned 257 premenopausal women with operable hormone-receptor-negative breast cancer to receive standard chemotherapy with the GnRH agonist goserelin (goserelin group) or standard chemotherapy without goserelin (chemotherapy-alone group). The primary study end point was the rate of ovarian failure at 2 years, with ovarian failure defined as the absence of menses in the preceding 6 months and levels of follicle-stimulating hormone (FSH) in the postmenopausal range. Rates were compared with the use of conditional logistic regression. Secondary end points included pregnancy outcomes and disease-free and overall survival. Results: At baseline, 218 patients were eligible and could be evaluated. Among 135 with complete primary end-point data, the ovarian failure rate was 8% in the goserelin group and 22% in the chemotherapy-alone group (odds ratio, 0.30; 95% confidence interval [CI], 0.09 to 0.97; two-sided P=0.04). Owing to missing primary end-point data, sensitivity analyses were performed, and the results were consistent with the main findings. Missing data did not differ according to treatment group or according to the stratification factors of age and planned chemotherapy regimen. Among the 218 patients who could be evaluated, pregnancy occurred in more women in the goserelin group than in the chemotherapy-alone group (21% vs. 11%, P=0.03); women in the goserelin group also had improved disease-free survival (P=0.04) and overall survival (P=0.05). Conclusions: Although missing data weaken interpretation of the findings, administration of goserelin with chemotherapy appeared to protect against ovarian failure, reducing the risk of early menopause and improving prospects for fertility. (Funded by the National Cancer Institute and others; POEMS/S0230 ClinicalTrials.gov number, NCT00068601.).New England Journal of Medicine 03/2015; 372(10):923-32. DOI:10.1056/NEJMoa1413204 · 55.87 Impact Factor
Article: Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: Introduction: Tumor lymphocyte infiltration is associated with clinical response to chemotherapy in estrogen receptor (ER) negative breast cancer. To identify variants in immunosuppressive pathway genes associated with prognosis after adjuvant chemotherapy for ER-negative patients, we studied stage I-III invasive breast cancer patients of European ancestry, including 9,334 ER-positive (3,151 treated with chemotherapy) and 2,334 ER-negative patients (1,499 treated with chemotherapy). Methods: We pooled data from sixteen studies from the Breast Cancer Association Consortium (BCAC), and employed two independent studies for replications. Overall 3,610 single nucleotide polymorphisms (SNPs) in 133 genes were genotyped as part of the Collaborative Oncological Gene-environment Study, in which phenotype and clinical data were collected and harmonized. Multivariable Cox proportional hazard regression was used to assess genetic associations with overall survival (OS) and breast cancer-specific survival (BCSS). Heterogeneity according to chemotherapy or ER status was evaluated with the log-likelihood ratio test. Results: Three independent SNPs in TGFBR2 and IL12B were associated with OS (P <10⁻³) solely in ER-negative patients after chemotherapy (267 events). Poorer OS associated with TGFBR2 rs1367610 (G > C) (per allele hazard ratio (HR) 1.54 (95% confidence interval (CI) 1.22 to 1.95), P = 3.08 × 10⁻⁴) was not found in ER-negative patients without chemotherapy or ER-positive patients with chemotherapy (P for interaction <10-3). Two SNPs in IL12B (r² = 0.20) showed different associations with ER-negative disease after chemotherapy: rs2546892 (G > A) with poorer OS (HR 1.50 (95% CI 1.21 to 1.86), P = 1.81 × 10⁻⁴), and rs2853694 (A > C) with improved OS (HR 0.73 (95% CI 0.61 to 0.87), P = 3.67 × 10⁻⁴). Similar associations were observed with BCSS. Association with TGFBR2 rs1367610 but not IL12B variants replicated using BCAC Asian samples and the independent Prospective Study of Outcomes in Sporadic versus Hereditary Breast Cancer Study and yielded a combined HR of 1.57 ((95% CI 1.28 to 1.94), P = 2.05 × 10⁻⁵) without study heterogeneity. Conclusions: TGFBR2 variants may have prognostic and predictive value in ER-negative breast cancer patients treated with adjuvant chemotherapy. Our findings provide further insights into the development of immunotherapeutic targets for ER-negative breast cancer.Breast cancer research: BCR 02/2015; 17(1). DOI:10.1186/s13058-015-0522-2 · 5.49 Impact Factor
Article: Transitioning to routine breast cancer risk assessment and management in primary care: what can we learn from cardiovascular disease?[Show abstract] [Hide abstract]
ABSTRACT: To capitalise on advances in breast cancer prevention, all women would need to have their breast cancer risk formally assessed. With ~85% of Australians attending primary care clinics at least once a year, primary care is an opportune location for formal breast cancer risk assessment and management. This study assessed the current practice and needs of primary care clinicians regarding assessment and management of breast cancer risk. Two facilitated focus group discussions were held with 17 primary care clinicians (12 GPs and 5 practice nurses (PNs)) as part of a larger needs assessment. Primary care clinicians viewed assessment and management of cardiovascular risk as an intrinsic, expected part of their role, often triggered by practice software prompts and facilitated by use of an online tool. Conversely, assessment of breast cancer risk was not routine and was generally patient- (not clinician-) initiated, and risk management (apart from routine screening) was considered outside the primary care domain. Clinicians suggested that routine assessment and management of breast cancer risk might be achieved if it were widely endorsed as within the remit of primary care and supported by an online risk-assessment and decision aid tool that was integrated into primary care software. This study identified several key issues that would need to be addressed to facilitate the transition to routine assessment and management of breast cancer risk in primary care, based largely on the model used for cardiovascular disease.Australian Journal of Primary Health 02/2015; DOI:10.1071/PY14156 · 0.96 Impact Factor
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ABSTRACT: This article reviews the evidence that underpins breast cancer screening and prevention strategies for women at high risk of the disease, with a particular focus on evidence published in the last 18 months. The review is timely because the US National Comprehensive Cancer Network, the UK National Institute for Health and Care Excellence and the American Society of Clinical Oncology have recently updated relevant guidelines that inform practice. In the recently published literature, there have been several important findings. A meta-analysis of randomized trials of selective oestrogen receptor modulators (SERMs), along with the first results from the International Breast Cancer Intervention Study II trial, further support the use of SERMs and aromatase inhibitors in the primary prevention of breast cancer. A large observational study has provided evidence that the SERM tamoxifen may be efficacious for breast cancer prevention in women who carry mutations in the breast cancer predisposition genes, BRCA1 and BRCA2. Several observational studies have suggested that contralateral risk-reducing mastectomy, following a diagnosis of breast cancer, may reduce mortality. Evidence regarding the optimal management of women at high risk of breast cancer continues to evolve and needs to be rapidly implemented into clinical practice.Current Opinion in Obstetrics and Gynecology 12/2014; 27(1). DOI:10.1097/GCO.0000000000000140 · 2.07 Impact Factor
- The Medical journal of Australia 10/2014; 201(7):381. DOI:10.5694/mja14.01203 · 4.09 Impact Factor
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ABSTRACT: Decision support tools for the assessment and management of breast cancer risk may improve uptake of prevention strategies. End-user input in the design of such tools is critical to increase clinical use. Before developing such a computerized tool, we examined clinicians' practice and future needs. Twelve breast surgeons, 12 primary care physicians and 5 practice nurses participated in 4 focus groups. These were recorded, coded, and analyzed to identify key themes. Participants identified difficulties assessing risk, including a lack of available tools to standardize practice. Most expressed confidence identifying women at potentially high risk, but not moderate risk. Participants felt a tool could especially reassure young women at average risk. Desirable features included: evidence-based, accessible (e.g. web-based), and displaying absolute (not relative) risks in multiple formats. The potential to create anxiety was a concern. Development of future tools should address these issues to optimize translation of knowledge into clinical practice.Breast (Edinburgh, Scotland) 07/2014; 23(5). DOI:10.1016/j.breast.2014.06.014 · 2.38 Impact Factor
Article: Women's preferences for selective estrogen reuptake modulators: An investigation using protection motivation theory[Show abstract] [Hide abstract]
ABSTRACT: Objective Selective Estrogen Receptor Modulators (SERMs) reduce breast cancer risk by 38%. However, uptake is low and the reasons are not well understood. This study applied Protection Motivation Theory (PMT) to determine factors associated with intention to take SERMs. Methods Women at increased risk of breast cancer (N = 107), recruited from two familial cancer clinics in Australia, completed a questionnaire containing measures of PMT constructs. Hierarchical multiple linear regression analysis was used to analyze the data. Results Forty-five percent of women said they would be likely or very likely to take SERMs in the future. PMT components accounted for 40% of variance in intention to take SERMs. Perceived vulnerability, severity and response efficacy appeared the most influential in women's decisions to take or not take SERMs. Conclusion Many women are interested in SERMs as a risk management option. Accurate risk estimation and an understanding of the benefits of SERMs are critical to women's decision making. Practice Implications: Health professionals need to explore women's perceptions of their risk and its consequences, as well as providing clear evidence-based information about the efficacy of SERMs. Exploring the source and strength of beliefs about SERMs may allow more effective, tailored counseling.Patient Education and Counseling 07/2014; 96(1). DOI:10.1016/j.pec.2014.04.011 · 2.20 Impact Factor
Article: 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.Nature Communications 06/2014; 5:4051. DOI:10.1038/ncomms5051 · 11.47 Impact Factor
Article: Women's preferences for selective estrogen reuptake modulators: an investigation using the time trade off technique[Show abstract] [Hide abstract]
ABSTRACT: Selective Estrogen Receptor Modulators (SERMs) reduce the risk of breast cancer for women at increased risk by 38%. However, uptake is extremely low and the reasons for this are not completely understood. The aims of this study were to utilize time trade-off methods to determine the degree of risk reduction required to make taking SERMs worthwhile to women, and the factors associated with requiring greater risk reduction to take SERMs. Women at increased risk of breast cancer (N = 107) were recruited from two familial cancer clinics in Australia. Participants completed a questionnaire either online or in pen and paper format. Hierarchical multiple linear regression analysis was used to analyze the data. Overall, there was considerable heterogeneity in the degree of risk reduction required to make taking SERMs worthwhile. Women with higher perceived breast cancer risk and those with stronger intentions to undergo (or who had undergone) an oophorectomy required a smaller degree of risk reduction to consider taking SERMs worthwhile. Women at increased familial risk appear motivated to consider SERMs for prevention. A tailored approach to communicating about medical prevention is essential. Health professionals could usefully highlight the absolute (rather than relative) probability of side effects and take into account an individual's perceived (rather than objective) risk of breast cancer.SpringerPlus 05/2014; 3(264). DOI:10.1186/2193-1801-3-264
Article: Misperceptions of ovarian cancer risk in women at increased risk for hereditary ovarian cancer[Show abstract] [Hide abstract]
ABSTRACT: This study assessed the sociodemographic, medical and psychological predictors of accuracy of perceived risk in women at increased genetic risk for ovarian cancer. Women participating in a large cohort study who were at increased risk of ovarian and fallopian tube cancer, had no personal history of cancer and had ≥1 ovary in situ at cohort enrolment, were eligible. Women completed self-administered questionnaires and attended an interview at enrolment. Of 2,868 women unaffected with cancer at cohort enrolment, 561 were eligible. 335 women (59.8 %) overestimated their ovarian cancer risk, while 215 women (38.4 %) accurately estimated their risk, and 10 (1.8 %) underestimated it. Women who did not know their mutation status were more likely to overestimate their risk (OR 1.74, 95 % CI 1.10, 2.77, p = 0.018), as were those with higher cancer-specific anxiety (OR 1.05, 95 % CI 1.02, 1.08, p < 0.001) and/or a mother who had been diagnosed with ovarian cancer (OR 1.98, 95 % CI 1.23, 3.18, p = 0.005). Amongst the group of women who did not know their mutation status, 63.3 % overestimated their risk and the mean perceived lifetime risk of developing ovarian cancer was 42.1 %, compared to a mean objective risk of 6.4 %. A large number of women at increased risk for ovarian cancer overestimate their risk. This is of concern especially in women who are at moderately increased risk only; for this sub-group of women, interventions are needed to reduce potentially unnecessary psychological distress and minimise engagement in unnecessary surgery or screening.Familial Cancer 10/2013; 13(2). DOI:10.1007/s10689-013-9687-y · 1.98 Impact Factor
Article: Do BRCA1 and BRCA2 Mutation Carriers Have Earlier Natural Menopause Than Their Noncarrier Relatives? Results From the Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer[Show abstract] [Hide abstract]
ABSTRACT: Limited data suggest that germline BRCA1 mutations are associated with occult primary ovarian insufficiency and that BRCA1 and BRCA2 mutation carriers might have earlier natural menopause (NM) than their noncarrier relatives. Eligible women were mutation carriers and noncarriers from families segregating a BRCA1 or BRCA2 mutation. Data were self-reported using uniform questionnaires at cohort entry and every 3 years thereafter. NM was defined as the cessation of menses for 12 months without another cause. Cox proportional hazards analysis modeled time from birth to NM, adjusting for multiple potential confounders. Analysis time was censored at the earliest of the following: last follow-up, bilateral oophorectomy, hysterectomy, commencement of hormone therapy, insertion of intrauterine device, or any cancer diagnosis. Hazard ratios (HRs) were estimated as a measure of how likely mutation carriers are, relative to noncarriers, to reach NM at a given age. A total of 1,840 women were eligible for analysis. Overall only 19% reached NM. A lower proportion of BRCA1 and BRCA2 mutation carriers reached NM compared with noncarriers. Conversely, a higher proportion of mutation carriers were censored at cancer diagnosis or oophorectomy than noncarriers. The adjusted HR estimates for NM were 1.03 (95% CI, 0.75 to 1.40; P = .9) for 445 BRCA1 mutation carriers and 559 noncarrier relatives and 1.01 (95% CI, 0.71 to 1.42; P = .9) for 374 BRCA2 mutation carriers and 462 noncarrier relatives. We found no evidence that BRCA1 and BRCA2 mutation carriers are at higher risk of NM at a given age than their noncarrier relatives.Journal of Clinical Oncology 09/2013; 31(31). DOI:10.1200/JCO.2013.49.3007 · 18.43 Impact Factor
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ABSTRACT: PURPOSETo determine whether adjuvant tamoxifen treatment for breast cancer (BC) is associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or BRCA2 mutation carriers. METHODS Analysis of pooled observational cohort data, self-reported at enrollment and at follow-up from the International BRCA1, and BRCA2 Carrier Cohort Study, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, and Breast Cancer Family Registry. Eligible women were BRCA1 and BRCA2 mutation carriers diagnosed with unilateral BC since 1970 and no other invasive cancer or tamoxifen use before first BC. Hazard ratios (HRs) for CBC associated with tamoxifen use were estimated using Cox regression, adjusting for year and age of diagnosis, country, and bilateral oophorectomy and censoring at contralateral mastectomy, death, or loss to follow-up.ResultsOf 1,583 BRCA1 and 881 BRCA2 mutation carriers, 383 (24%) and 454 (52%), respectively, took tamoxifen after first BC diagnosis. There were 520 CBCs over 20,104 person-years of observation. The adjusted HR estimates were 0.38 (95% CI, 0.27 to 0.55) and 0.33 (95% CI, 0.22 to 0.50) for BRCA1 and BRCA2 mutation carriers, respectively. After left truncating at recruitment to the cohort, adjusted HR estimates were 0.58 (95% CI, 0.29 to 1.13) and 0.48 (95% CI, 0.22 to 1.05) based on 657 BRCA1 and 426 BRCA2 mutation carriers with 100 CBCs over 4,392 person-years of prospective follow-up. HRs did not differ by estrogen receptor status of the first BC (missing for 56% of cases). CONCLUSION This study provides evidence that tamoxifen use is associated with a reduction in CBC risk for BRCA1 and BRCA2 mutation carriers. Further follow-up of these cohorts will provide increased statistical power for future prospective analyses.Journal of Clinical Oncology 08/2013; 31(25). DOI:10.1200/JCO.2012.47.8313 · 18.43 Impact Factor
Article: Using SNP genotypes to improve the discrimination of a simple breast cancer risk prediction model[Show abstract] [Hide abstract]
ABSTRACT: It has been shown that, for women aged 50 years or older, the discriminatory accuracy of the Breast Cancer Risk Prediction Tool (BCRAT) can be modestly improved by the inclusion of information on common single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risk. We aimed to determine whether a similar improvement is seen for earlier onset disease. We used the Australian Breast Cancer Family Registry to study a population-based sample of 962 cases aged 35-59 years, and 463 controls frequency matched for age and for whom genotyping data was available. Overall, the inclusion of data on seven SNPs improved the area under the receiver operating characteristic curve (AUC) from 0.58 (95 % confidence interval [CI] 0.55-0.61) for BCRAT alone to 0.61 (95 % CI 0.58-0.64) for BCRAT and SNP data combined (p < 0.001). For women aged 35-39 years at interview, the corresponding improvement in AUC was from 0.61 (95 % CI 0.56-0.66) to 0.65 (95 % CI 0.60-0.70; p = 0.03), while for women aged 40-49 years at diagnosis, the AUC improved from 0.61 (95 % CI 0.55-0.66) to 0.63 (95 % CI 0.57-0.69; p = 0.04). Using previously used classifications of low, intermediate and high risk, 2.1 % of cases and none of the controls aged 35-39 years, and 10.9 % of cases and 4.0 % of controls aged 40-49 years were classified into a higher risk group. Including information on seven SNPs associated with breast cancer risk, improves the discriminatory accuracy of BCRAT for women aged 35-39 years and 40-49 years. Given, the low absolute risk for women in these age groups, only a small proportion are reclassified into a higher category for predicted 5-year risk of breast cancer.Breast Cancer Research and Treatment 06/2013; 139(3). DOI:10.1007/s10549-013-2610-2 · 3.94 Impact Factor
Top Journals
University of Melbourne
Melbourne, Victoria, Australia
- • Department of Medicine
- • Genetic Epidemiology Laboratory
Saint Vincent HospitalWorcester, Massachusetts, United States
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia
- • Department of Cancer Medicine
- • Division of Haematology and Medical Oncology
- • Peter MacCallum Cancer Center
University of Cambridge
Cambridge, England, United Kingdom
- Department of Public Health and Primary Care
University of OtagoTaieri, Otago, New Zealand
The Princess Margaret HospitalToronto, Ontario, Canada


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Bench Memos
Biglaw, Blogging, Clerkships, Federal Judges, Gay, Gay Marriage, Law Professors, Law Schools, Non-Sequiturs, SCOTUS, State Judges, Supreme Court, Videos
* Here's the answer to the question everyone's been asking since December: the Supreme Court will be hearing the gay-marriage cases on March 26 (Prop 8) and March 27 (Windsor). No extra time for args? [WSJ Law Blog (sub. req.)]
* Wherein Scott Greenfield responds to Mark Herrmann's thoughts on bench memos — or, in Greenfield's words, why our important appellate decisions shouldn't be left "in the hands of children" (aka law clerks). [Simple Justice]
* Will the latest massive mortgage settlements lead to lawyer layoffs? [Going Concern]
* Cy Vance's ears must've been ringing when this opinion came out, because the judges on this appellate panel said the prosecution's case was based on "pure conjecture bolstered by empty rhetoric." [WiseLawNY]
* Apparently a Santa Clara law professor is getting pummeled in the comments on various law blogs because of his thoughts on law school. As Rihanna would say, "Shine bright like Steve Diamond." [Constitutional Daily]
* Meditation and mindfulness are more mainstream than ever in the practice of law, but given all the tales of stressed out lawyers' alleged misconduct we hear about, you certainly wouldn't know it. [Underdog]
* And from our friends at RollOnFriday, you can see what the folks at Norton Rose do in their spare time….
Thanks to the Norton Rose / Fulbright & Jaworski merger, lawyers at Fulbright will soon be working Gangnam Style with all of this fabulosity. Aren't you excited to be joining them in doing the hallway horsey dance?
Inside Straight: Reforming The Bench Memo Process
Wherein Mark Herrmann makes a plea to the federal courts as to law clerks and the drafting of bench memos.
Inventors Will Lead the Legal Future not Licensees
David McCullough's The Wright Brothers serves as an ideal case study on the requirements to innovate; a desire to learn, perseverance, and work ethic. I read it in route to a wonderful opportunity to serve as visiting lecturer for Professor and Parsons Behle & Latimer attorney Randy Dryer's innovative Technology and Modern Litigation course at […]

subset: commoncrawl


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Tuesday, 2 November 2004
Presenter: Madeleine Randall
Health and fitness
There's a great deal of research that suggests people who drink alcohol are less likely than teetotallers to experience cardiovascular diseases. So when it comes to heart health, is one form of alcoholic drink better than another? For example, which should we choose ... red wine or gin?Madeleine Randall discussed this with Associate ProfessorGordon Lynch who is Reader in Physiology at the University of Melbourne.Among the issues they discussed : - how might alcoholic drinks have a protective effect on the heart?- what is the link to atherosclerosis or hardening of the arteries?- the latest research: red wine versus gin - which was better?- alcohol only has beneficial effects when taken in moderation - how much is enough? what's too much?Gordon concluded by putting it all into perspective - and explaining where wine fits in to the health picture, explaining that exercise and good nutrition are still all-important.Would you like more information on Health and Fitness?Read all the stories in our series here
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Ridley Scott's The Counselor Piques Interest of Fox, Angelina Jolie
Cormac McCarthy, Michael Fassbender, and maybe Angelina Jolie? What a squad!By Claude Brodesser-Akner
Cormac McCarthy, Michael Fassbender, and maybe Angelina Jolie? What a squad!By Claude Brodesser-Akner
Jack Nicholson in the lead, Angelina Jolie as his ex-wife.By Andre Tartar
Her leg remains quiet and mysterious.By Kyle Buchanan
She'd play Sleeping Beauty.By Margaret Lyons
J. Lo and Angie both got Twitter accounts for body parts tonight.By Zach Dionne
"We haven't even started on this movie yet! And the idea has nothing to do with the way I met her or anything to do with her."By Miranda Siegel
It's a road movie inspired by their relationship.By Kyle Buchanan
From the cast of Moneyball to Glee, check out last night's Red Carpet at the SAG Awards.By Eric Sundermann
Sarah Michelle Gellar? Surprisingly good! Mila Kunis? Surprisingly boring!By The Fug Girls
So that's not Angelina Jolie sitting down for an awkward interview? Because we feel like we've seen this before ...By Eliot Glazer
A dramatic thriller.By Margaret Lyons
In the Land of Blood and Honey required a lighter touch.By Jennifer Vineyard
We believe it.By Caroline Bankoff
It won't be released in English anymore.By Kyle Buchanan
It's her directorial debut.By Kyle Buchanan
It's all in the Twitter, apparently.By Caroline Bankoff
Angelina is into it, so the studio just commissioned a script.By Kyle Buchanan
What does Angelina Jolie think about Osama bin Laden? And do pandas have existential problems?By Jada Yuan
From Angelina Jolie in radiant, life-giving green to Kate Hudson taking the concept of belly dancing to distracting new levels.By The Fug Girls


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OSI-Approved Open Source (174)
- GNU General Public License version 2.0 (137)
- GNU Library or Lesser General Public License version 2.0 (13)
- GNU General Public License version 3.0 (8)
- BSD License (7)
- MIT License (6)
- Academic Free License (2)
- Affero GNU Public License (2)
- Artistic License (2)
- Qt Public License (2)
- Apache License V2.0 (1)
- Common Development and Distribution License (1)
- Common Public License 1.0 (1)
- GNU Library or Lesser General Public License version 3.0 (1)
- Microsoft Public License (1)
- Mozilla Public License 1.1 (1)
- Public Domain (13)
- Other License (2)
- Windows (179)
- Grouping and Descriptive Categories (158)
- Linux (137)
- Mac (88)
- Modern (60)
Role-Playing Software
- Status: 7 - Inactive ×
Twisted Sanctum ManGoS MMORPG Emulator
A Pre-TBC MMORPG based of MaNGOs (http://www.mangosproject.org, full credits to them) Client Patch: Retail 1.12.1 Required0 weekly downloads
Stallion: Online Game Codebase
A codebase for the construction of 3d online virtual worlds. Includes everything you need to make your own multiplayer online roleplaying game. All game rules are contained in plugins which can be written in easy scripting languages such as Python.1 weekly downloads
Eve Skill Monitor Cocoa
Eve Skill Monitor Cocoa is a, easy-to-use standalone Cocoa (mac) application designed to assist you in keeping track of your EVE Online character progression.0 weekly downloads
ThunderBolt OTS
An Open Tibia server project that uses MySQL and Lua Scripting language.1 weekly downloads
JXB's MapEditor
A tool to build maps to be used inside ThunderBolt OpenTibia Servers, and others OTserv's [oldie ones]14 weekly downloads
BoA Editor Remake
A collaborative effort to remake the Blades Of Avernum Scenario Editor.1 weekly downloads
Angelion - The Demon Conflict
[DISBANDED] Isometric client/server based MMORG Featuring: 2d+ (isometric mapstacking), tilestretching (looks 3d) and realtime map editing. Uses SDL graphics library for portability.5 weekly downloads
jathena is a japanese, open source server for ragnarok online. It is written in C.5 weekly downloads
Galaxy Raiders
Galaxy Raiders is an Open-Source derivative of Solar Empires, with elements of many of today's popular space-based MMORPG's. Development has ceased. Anyone interested in taking over, let me know.0 weekly downloads
A general purpose tool for running D&D 3.5 campaigns. Targetted features include a user interface that doesn't look like the tabbed panel full of spreadsheets that most character generaters use and asynchronous network updates between DMs and Players.0 weekly downloads
Downlink - multiplayer hacker game fun
Downlink will be a multiplayer game featuring 4 player classes (business, media, security, sysop) and in-game internet elements (chat rooms, instant messaging, WWW, newsgroups, ...) that allow for RPG like gaming (the 'internet' being how you move about).0 weekly downloads
Oak Hill Caverns
(DEVELOPMENT CEASED)5 weekly downloads
Survival Server
An open and free Tibia MMORPG server and programs to control it.1 weekly downloads
SoraSky ermöglicht es selbst Spiele in Form einer Visual Novel/Dating Sim zu erstellen. Dazu wird lediglich eine Textdatei sowie bei Bedarf zu verwendende Bilder benötigt.1 weekly downloads
Heretic / Hexen
Activision and Raven are releasing this code for people to learn from and play with. This code is copyright Activision 1996-1998 Originaly release 6 Jan 1999 under a different EULA. This source is released under GNU GPLv2.21 weekly downloads
Slipstream is a kind of fiction that crosses conventional genre boundaries. It cannot be defined as either science fiction/fantasy or mainstream fiction.0 weekly downloads
Neko Ganbaru!
Command-line interface Adventure RPG. (this project is set inactive because all the development source code on my hard disk gone. sorry for the inconvenience)1 weekly downloads
Shadowrun Online
Shadowrun Online is a DTTORPGA (Distributed TableTop Online Role Playing Game Aid), for the game Shadowrun. This project is planned to allow players and GMs all over the world to come together, with a 1st person interface and module editing tools.1 weekly downloads
PHPAdventure! is an interactive fiction engine written in PHP that allows game programmers to easily create point-and-click web based text adventure games. May 2006: I'm not maintaining this anymore. If you want to take it over, let me know.1 weekly downloads
Tools for Advanced Athala
Notre but est de développer des outils utiles pour jouer au JDR gratuit Advanced Athala.1 weekly downloads
Survival is an rpg-like game, which is focused on the survival in the wilderness of the player character, it hopes to be as opened ended as possible, with the player being able to create tools and homes, in the randomly generated 3d world.1 weekly downloads
MUCH - MUd Creator Helper
This Project is intended, to be a graphical, easy to use interface for MUD-maintainers and -programmers, as well as beginners, to assist and help creating LPMuds by means of LPC (the LPMud-language).0 weekly downloads
Last Remaining
Last Remaining is a first person shooter and role-playing game in the same vein as Deus Ex. There will be an engrossing storyline, and the player must take whatever action is necessary to get to the bottom of the mystery.1 weekly downloads
Imaginary Worlds
Windows and Linux based multi-user FRP game which will allow for all aspects of role-playing, including: erotic roleplaying, customizations (weapons, equipment, clothes, animations, etc.)0 weekly downloads
OGame Skins Maker
OGame Skins Maker helps you creating your own OGame Skins thanks to its CSS opitmized editor, its skin-viewer and its wizard.3 weekly downloads


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The Chrome team is delighted to announce the promotion of Chrome 46 to the stable channel for Windows, Mac and Linux.
Chrome 46.0.2490.71 contains a number of fixes and improvements -- a list of changes is available in the log. Watch out for upcoming Chrome and Chromium blog posts about new features and big efforts delivered in 46.
Security Fixes and Rewards
Note: Access to bug details and links may be kept restricted until a majority of users are updated with a fix. We will also retain restrictions if the bug exists in a third party library that other projects similarly depend on, but haven't yet fixed.
This update includes 24 security fixes. Below, we highlight fixes that were contributed by external researchers. Please see the Chromium security page for more information.
[$8837][519558] High CVE-2015-6755: Cross-origin bypass in Blink. Credit to Mariusz Mlynski.
[$6337][507316] High CVE-2015-6756: Use-after-free in PDFium. Credit to anonymous.
[$3500][529520] High CVE-2015-6757: Use-after-free in ServiceWorker. Credit to Collin Payne.
[$3000][522131] High CVE-2015-6758: Bad-cast in PDFium. Credit to Atte Kettunen of OUSPG.
[$1000][514076] Medium CVE-2015-6759: Information leakage in LocalStorage. Credit to Muneaki Nishimura (nishimunea).
[$1000][519642] Medium CVE-2015-6760: Improper error handling in libANGLE. Credit to lastland.net.
[$500][447860 & 532967] Medium CVE-2015-6761: Memory corruption in FFMpeg. Credit to Aki Helin of OUSPG and anonymous.
[$500][512678] Low CVE-2015-6762: CORS bypass via CSS fonts. Credit to Muneaki Nishimura (nishimunea).
We would also like to thank all security researchers that worked with us during the development cycle to prevent security bugs from ever reaching the stable channel. The total value of additional rewards and their recipients will updated here when all reports have gone through the reward panel.
As usual, our ongoing internal security work was responsible for a wide range of fixes:
- [542517] CVE-2015-6763: Various fixes from internal audits, fuzzing and other initiatives.
- Multiple vulnerabilities in V8 fixed at the tip of the 4.6 branch (currently 18.104.22.168).
Many of the above bugs were detected using AddressSanitizer or MemorySanitizer.
Interested in switching release channels? Find out how. If you find a new issue, please let us know by filing a bug. The community help forum is also a great place to reach out for help or learn about common issues.
Tina ZhouGoogle Chrome


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Select Local Merchants
Perfect Skin SolutionsRead MoreLed by Perfect Skin Solutions medical director Dr. Kannan Sundar, licensed medical aesthetician Peggy Schremser restores or maintains clients' youthful looks with exfoliating chemical peels, dermaplaning, and micro-skin needling sessions. She employs high-potency products such as a peptide-booster serum that combats fine lines and a vitamin-C "super serum" that can protect skin from sun damage, pollution, or windburn while flying around Metropolis. Schremser is also certified in the application of permanent makeup.11300 Distinctive Dr.Orland Park, IL US
Fine Skin Dermatology and Medical SpaRead MoreFine Skin Dermatology and Medical Spa director Renuka H. Bhatt, MD keeps a close eye on her staff of board-certified dermatologists, aestheticians, and physicians' assistants as they work to foster skin rejuvenation. Like schoolchildren solving a word problem about peaches, techs trained in IPL hair removal deftly subtract fuzz, and visages in need of a pick-me-up can turn to a range of dermal fillers and UV-light treatments. Throughout their myriad treatments, skin specialists employ skin-preserving product lines such as NeoStrata, Pevonia, Kinerase, and Obagi.10811 West 143rd StreetOrland Park, IL US
A New You Plastic Surgery and Laser CenterRead MoreA New You Plastic Surgery and Laser Center in Orland Park provides a wide array of cosmetic procedures for both men and women. Reap the benefits of a professional skin care treatment from A New You Plastic Surgery and Laser Center, such as IPL. From minor procedures to big changes, the surgeons at A New You Plastic Surgery and Laser Center are ready to accommodate anything you're looking to make happen.15432 S Harlem AveOrland Park, IL US
Orland Park Plastic Surgery, S.CRead MoreBoost your confidence with a fresh new look, courtesy of the professional surgeons at Orland Park Plastic Surgery, S.C in Orland Park. With IPL, you are sure to find a good skin care treatment match for your skin type at Orland Park Plastic Surgery, S.C. The doctors at Orland Park Plastic Surgery, S.C make their patients dreams a reality, so you can feel secure in exploring their many options.8760 West 159th StreetOrland Park, IL US
Orland Cosmetic SurgeryRead MoreThe professional surgeons at Orland Cosmetic Surgery in Orland Park are here to help you meet your beauty enhancement goals. Enjoy a professional skin care treatment at Orland Cosmetic Surgery and leave feeling refreshed. Orland Cosmetic Surgery's doctors are committed to their patients' happiness. Call today to set up a consultation.15448 Harlem AvenueOrland Park, IL US
Jerry ChowRead MoreThe surgeons at Orland Park's Jerry Chow are more than welcome to help you customize a cosmetic surgery. Jerry Chow provides exceptional and gentle medical treatments, such as physicals and medical checkups. Cosmetic surgery is sure to bring up a lot of question, so stop in at Jerry Chow for a consultation today.15300 West AvenueOrland Park, IL US


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View jewish Singles in League City
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Radio Pro DJs
The Hip Hop / Rap music deejay from Radio Pro DJs was fantastic and perfect for a wedding reception. They really managed to make the reception a lot of fun for everybody involved.
XXL Productions Video dj shows
An ingenious Classical music DJ from XXL Productions Video dj shows can make sure that your party is beyond energetic and truly next level.
Stevens DJ Service Inc
Modern equipment, punctuality and the right attitude, along with great Hip Hop / Rap music make Stevens DJ Service Inc disc jockey services the best in Riverton.
A Touch of Class
The special event disc jockey was seasoned and known throughout Riverton for Irish music. The selection of music was well beyond anything anybody would've anticipated.
Music Source Professional Disc Jock...
In Riverton, remember that Music Source Professional Disc Jockey Service provides you with the best party deejay services and R & B music you'll find anywhere.
A Dynamic Sound DJ Service
Everyone wants Irish music at their wedding receptions, and the event DJs at A Dynamic Sound DJ Service bring the best, whether it is contemporary or classic.


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Our family stayed in a motel room for two nights while traveling to the UP. Mr. Lee started us our own campfire and took time to chat with us. Our room looked like new. Very clean. Not a weed on the property. We stopped for one more night on our way back home and stayed in one of the condos. It looked newly remodeled. Our children enjoyed swimming at the resort's beach, playing on the playground, and fishing from the dock. That evening, Mr. Lee started another fire just in case we wanted one. His resort is beautiful, and he takes good care of his vacationers. -Doug, Ohio
Location: United States > Michigan > Houghton Lake
Ranked #6 of 14 Hotels in Houghton Lake
Number of rooms: 16


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USER EDITORHo_Man
User Score: 249
When Keller approached Schillinger and Robson in the cafeteria to taunt Schillinger, Keller had a blue/purple colored fruit drink on his food tray. When he began to follow Schillinger and Robson as they left, the drink was orange.
Haldol, the drug Cyril is given, is injected IM (IntraMuscular), not IV (IntraVenously), as is depicted. The needle would be stuck randomly into his bicep or thigh to administer this medicine.
Prisoners featured
Detective Bruno Gergan, convicted March 15th 2000, illegal possession and sale of
firearms, murder in the first degree. Sentence: 36 years, up for parole in 18. (prisoner # 00G115)
Kevin Ketchum, AKA Supreme
Allah, convicted March 22nd, 2000, murder in the second degree. Sentence: 25 years, up for parole in 10. (prisoner #00K251)
Patrick Keenan, convicted
March 25th, 2000, assault in the first degree, rape. Sentence: 12
years, up for parole in 7. (prisoner # 00K414)
When Keller returned to his cell, he stands with his back to the camera and is not wearing a shirt. There are no signs of scars where he had been stabbed not even one year earlier.
This episode features the show's only permanent prisoner "release" of Jason Cramer (Robert Bogue). Others have been released but later returned.
Prisoner featured
Enrique Morales, convicted April 6th 2000, murder in the 2nd degree. Sentence: 25 years, up for parole in 15. (prisoner # 00M871)
When Glynn and Basil/Mobay discuss that he can't use drugs because it would be a violation of regulations. However, back in season 1, Paul Markstrom, also an undercover cop, seemed to be consuming drugs along with Adebisi's crew.
Crime Flashbacks:
Mark Miles kills his wife and son. 10 years later, he kills his next set of wife and children.
Carlos Martinez murders an elderly man, then goes to the man's car to finish off the wife.
Prisoners featured
Mark Miles, convicted July 10th 1997, 3 counts murder in the first degree. Sentence: Death. (prison # 97M573)
Carlos Martinez, convicted October 6th, 1998, two counts of murder in the 1st degree. Sentence: life without the possibility of parole. (prison # 98M232)
Prisoners featured
Louis Bevilaqua, convicted April 2nd, 1999, murder in the 2nd degree, illegal possession of a firearm. Sentence: 25 years, up for parole in 12. (prisoner# 99B521)
Moses Deyell, convicted February 3rd, 2000, 2 counts of murder in
the first degree. Sentence: Death. (prisoner # 00D718)
Guillaume Tarrant, convicted January 2nd
2000, destruction of private property, concealment of a deadly weapon.
Sentence: 10 years, up for parole in 3. (prisoner # 00T416)
When Schillinger recieves a picture of his son Hank, he says to Robson he hasn't seen him "not since i came to Oz". with Schillinger's conviction in 92', this conflicts with him telling McMcanus and Mukada about his two sons visiting him in "A Game Of Checkers", season 1's finale, which occured in the summer of 97'.
The year of Bevilaqua's conviction is given as 1999, but the character was first referred to in 1998.
When Ryan is talking to Murphy about the boxing matches, Murphy's hand is resting on the table but in the next shot, it is up towards his face.
Alvarez has "McManus sucks my cock" scratched into the wall of his cell in solitary.
In this episode Alvarez informs Glynn that Carlo Ricardo raped his daghter, but we find out in ('Cock and Balls Story', Epi 1 Season 4) that it's not true.
In this episode, Warden Glynn goes from having a full beard, to a goatee, back to a full beard before finally going back to a goatee.
During the S.O.R.T. raid we see that Cyril and Ryan are in the gym with the others. But, when OZ goes into lockdown we see that Cyril is sitting at a table with a bandana on spinning a book on his finger, like he was previously in the episode. How can he be in two places at once?
Prisoner featured
Hamid Khan, convicted March 6th 1999, aggravated assault. Sentence: 10 years, up for parole in five. (prisoner # 99K515)
O'Reily's arm is sporting a bandage during Poet's recital in the Mess Hall, but he's not shown removing the tattoo until the shower scene a few minutes later.
Prisoners featured
William Cudney, convicted February 10th 1999, murder in the first degree. Sentence: Life without the possibility of parole. (prison # 99C124)
Yuri Kosygin, convicted March 23rd 1999, eight counts murder in the first degree, four counts attempted murder, illegal possession of a firearm. Sentence: Life imprisonment without the possibility of parole. (prison # 99K871)
User Score: 249
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User Score: 84
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Thrillers, gritty crime scenarios, Crime, gritty cinematography, cerebral


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Welcome to the Calandra Institute!
Position opening: Student Psychological Counselor, John D. Calandra Italian American Institute. Click here for more information on this position and to apply.
Watch this beautiful video about the Summer study program in Calabria co-hosted by the University of Calabria and the Calandra Institute, Queens College, CUNY.
Click here to see photographs (courtesy Volney Fray) from the Calandra Institute's "An Evening in Lazio" event, held September 16 at Piccolo Fiore restaurant.
Click here to read about the traveling exhibit
"La Madonna Nera in Italy and Europe."
Job Opening: Calandra Institute. Click here to read the vacancy notice for the job of Administrative Coordinator at the John D. Calandra Italian American Institute.
Calandra Institute's 2016 College Scholarship Handbook
We are pleased to announce the publication of the Calandra Institute's 2016 College Scholarship Handbook.
This directory provides information on well over one hundred scholarships available to Italian American students and students of Italian studies. Please be advised that the Calandra Institute does not provide additional scholarship information. Contact the sponsoring organization directly for more information.
Click here to view or download the pdf document.
The 2015 Italian Diaspora Studies Summer School with the Calandra Institute and the Università della Calabria. To see more images from this landmark program, click here.
Images from the annual Italian-American Day in Albany, New York, sponsored by the New York Conference of Italian-American State Legislators.
Left: Associate Director of Administration, Calandra Institute, Rosaria Musco; Italics Producer and Correspondent Lucia Grillo; York College Professor and Interim Dean for Arts & Sciences Donna Chirico.
Right: State Senator David Carlucci; Donna Chirico; Governor Andrew Cuomo.
Call for Papers
Calandra Institute International Conference 2016
"Migrating Objects: Material Culture and Italian Identities"
Call for Applications for the Position of Editor of the Italian American Review


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Select Local Merchants
Taylor B PhotographyRead MoreTaylor Boone's effusive personality lends itself well to her photography, where she creates a comfortable atmosphere for everything from family portraits to boudoir shoots. During each session, her gentle encouragement and seasoned guidance helps her clients' truest selves to shine through in each photograph. She possesses a versatile knack for style, creating a dreamlike softness for baby pictures and an editorial edginess for senior portraits as easily as the timeless vintage air she adds to boudoir shots. Beyond imbuing the photos with style, her postsession editing can also subtly cover imperfections and reveal hidden messages formed in tendrils of hair.13065 Southwest Seca CourtPortland, OR US
A. Lindahl CreationsRead MoreThough they began as hobbies, art and photography had become focal points for Amanda Lindahl-Lemke by college. After six years studying both subjects stateside—with a stint at art school in Florence, Italy, in between—Amanda made the leap to the pros with A. Lindahl Creations. Whether clicking away in her studio or on location, she primarily photographs newborns and children, all adorably posed in color and black-and-white prints that subvert expectations through her use of props and surreal backdrops. Before her sessions even begin, Amanda discusses expectations and aesthetic preferences with her clients and takes time to forge bonds with each child, expectant mother, or family she photographs. The warm, hands-on approach earned her the "Friendliest Family Photographer" spot in "Red Tricycle's" Totally Awesome Awards, which led to "Blue Tricycle's" subsequent Even More Awesomer Than Your Awards Awards: No Tag-Backs Edition. After their shoot, clients can share a private online gallery with family and friends or peruse it for the images they want to preserve as prints.17 SE 3rd AvePortland, OR US
Aedan StudioRead MoreAedan Studio Photography's owner and principal photographer fell in love with cameras at first sight, inspiring her to set up her first darkroom in her grandparents' garage at the tender age of 13. The studio's memory-preservation specialists focus their lenses on capturing the genuineness of each moment, snapping shots of families, pets, and babies as they laugh and smile through unposed interactions. Photo sessions can take place in the fully equipped studio or at a picturesque outdoor setting, such as a vibrant park or a volcano erupting with baking soda and vinegar. The professional picture takers also visually immortalize monumental events such as weddings and bar mitzvahs.158 NE 2nd AveHillsboro, OR US
Fireworks PhotographyRead MoreDuring in-studio and on-location shoots, Fireworks Photography's pro shuttberbugs focus camera eyes on weddings, senior pictures, family portraits, and more, capturing all moments with a sharp, clean look. They include unlimited poses and wardrobe changes with all shoots and print photos with a high-quality, metallic finish. For easy access to every image captured at sessions, they also put together private, online galleries for perusal, allowing customers to pick and choose the photos they'd like printed.1436 A St.Washougal, WA US
Yuen Lui StudioRead MoreYuen Lui Studio, a family-owned photography business specializing in individual and family portraits and wedding photography, creates visual heirlooms in a tradition of quality it has upheld since 1947. With several area studios available, each boasts a multitude of backdrop options for portraiture sessions, or photographers may take sessions outdoors to add natural scenery to the frame. Wedding and engagement shots come to life under the careful eyes of each photographer as they seize rare moments and trap them in frames to be displayed like trophies from a hunt. High-school, child, baby, and family portraits keep precious memories locked in time for clients, who can peruse an online gallery of their images after their session.1955 Clackamette Dr.Oregon City, OR US
Kati Nicole PhotographyRead MoreWhat services does your business offer and what makes your business stand out from the competition? I'm excited to work with you! I love meeting new people and capturing everyone's unique story. I am a natural light photographer, resulting in crisp bright and airy photos. I work with you before our shoot to make sure you're comfortable and fully prepared. I want you to have as much fun as I do! What was the inspiration to start or run this business? I started shooting in highschool but got serious in college. I have always loved meeting new people and connecting and photography has been an amazing stepping stone for that. My inspiration grows with every relationship I make, always learning new ways to produce the best. What do you love most about your job? The clients I have. My work comes from 90% referral and I am lucky to work with such happy and supportive people. Without clients there is no job and I love knowing I'm able to make others happy with what I do. What is the best reaction you've ever gotten from a customer? That I am the easiest and warmest person they've ever worked with.325 East Gloucester StreetGladstone, OR US


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For your benefit, our Library Resources are:
Fully editable (Microsoft Word)
Easily accessible 24/7. No special computer expertise needed
Invaluable and affordable
Downloadable directly to your computer 24/7
Updated regularly and Members are informed of updates individually. Free updates in the first year
...and, we act on Library Members' suggestions for new material for the benefit of all
Call 01234 349852 to join over the phone, or go online to join here.
The contents of the Library are available for you to review. Click on one of the Word icons below for your area of interest. Our Full Packages are a comprehensive collection of materials essential for the running of a care operation, and include a set of Policies and Procedures. These same Policies and Procedures are also available as a separate and cheaper package.
Contact us — Tel: 01234 349852. Or Click Here to Send us an Email


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The Large Hadron Collider
A student at the University of Nebraska-Lincoln, Derek Weitzel, completed a student project that shows the real-time transfers of data in our HDFS system. Called HadoopViz, this visualization shows all packet transfers in the HDFS system as raindrops arcing from one server to the other. The figure below shows a still shot.
Once the data is stored at a Tier-2, physicists need to be able to analyze it to make their discoveries. The platform for this task is Linux. For the sake of standardization, most of the development occurs on Red Hat Enterprise-based distributions. Both CERN and FNAL have their own Linux distributions but add improvements and customizations into the Scientific Linux distribution. The Tier-2 at Nebraska runs CentOS as the primary platform at our site.
With data files constructed to be about 2GB in size and data sets currently hovering in the low terabyte range, full data set analysis on a typical desktop is problematic. A typical physics analysis will start with coding and debugging taking place on a single workstation or small Tier-3 cluster. Once the coding and debugging phase is completed, the analysis is run over the entire data set, most likely at a Tier-2 site. Submitting an analysis to a grid computing site is not easy, and the process has been automated with software developed by CMS called CRAB (CMS Remote Analysis Builder).
To create a user's jobs, CRAB queries the CMS database at CERN that contains the locations where the data is stored globally. CRAB constructs the grid submission scripts. Users then can submit the entire analysis to an appropriate grid resource. CRAB allows users to query the progress of their jobs and request the output to be downloaded to their personal workstations.
CRAB can direct output to the Tier-2 storage itself. Each CMS user is allowed 1 terabyte of space on each Tier-2 site for the non-archival storage of each user's analysis output. Policing the storage used by scientists is a task left to the Tier-2 sites. HDFS's quota functionality gives the Nebraska Tier-2 administrators an easily updated tool to limit the use of analysis space automatically.
Figure 3 shows a simulated event seen through CMS, and Figure 4 shows an actual record event.
The LHC will enable physicists to investigate the inner workings of the universe. The accelerator and experiments have been decades in design and construction. The lab is setting new benchmarks for energetic particle beams. Everyone I talk to about our work seems to get glossy-eyed and complain that it is just too complex to comprehend. What I want to do with this quick overview of the computing involved in the LHC is tell the Linux community that the science being done at the LHC owes a great deal to the contributors and developers in the Open Source community. Even if you don't know your quark from your meson, your contributions to open-source software are helping physicists at the LHC and around the world.
Carl Lundstedt received his PhD in high-energy particle physics from the University of Nebraska-Lincoln (UNL) in 2001. After teaching introductory physics for five years, he is now one of the administrators of the CMS Tier-2 computing facility located at UNL's Holland Computing Center.
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In anticipation of CMS' policy memorandum, PMSI developed a methodology for prescription drug calculations based on its 34 years of experience as one of the largest providers of Pharmacy Benefit Management (PBM) services to the workers' compensation industry. PMSI's methodology incorporates the company's knowledge of occupational diagnoses, the treatment of pain management and the selection of replacement drugs for non-Part D covered prescriptions. In use for over nine months, this methodology reduced a MSA by $935,000 in one recent client case.
Takemoto continued, "PMSI applauds CMS for clarifying this important issue. We have valued the opportunity to meet with CMS numerous times over the past year and look forward to continuing our active dialogue with CMS on further refinement of the MSA drug review process and other issues impacting Medicare Set-Aside allocations."
About PMSI Settlement Solutions:
PMSI Settlement Solutions is recognized as a pioneer in Medicare Set-Aside allocations. PMSI Settlement Solutions offers a comprehensive menu of services for workers' compensation and liability/no-fault auto claims that are focused on settling claims in the most timely, cost-effective manner and in compliance with all government requirements. On-staff specialists are experts in lien negotiations, future medical cost projections and allocation preparation for cases in workers' compensation and liability. PMSI Settlement Solutions is a division of PMSI, one of the nation's largest providers of specialty managed care services and products for workers' compensation and liability markets. To learn more about PMSI Settlement Solutions, our services and web-enabled, integrated capabilities visit us at
|Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved


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Brazil's Straw Hat project helps women leave abusive situations
Saudi, Iran and the 'war' over the Hajj stampede
24 Sep 2012 15:30 GMT | Politics, Asia, Kazakhstan
The prime minister of Kazakhstan has resigned after leading the oil-rich Central Asian nation for five years and shepherding its economy through the global financial crisis.
Karim Massimov's resignation was accepted on Monday by a presidential decree, which also resulted in his appointment to the position of head of President Nursultan Nazarbayev's administration.
Massimov was the longest-serving head of government in the former Soviet nation's history and is widely respected in the international investor community.
Real power in Kazakhstan is held by Nazarbayev, but Massimov has been seen as an influential and competent steward of economic affairs.
His resignation had been expected, and is widely seen as an attempt by Nazarbayev to consolidate power.
A government source told the AFP news agency that Massimov's place will be taken by Serik Akhmetov, first deputy prime minister.
New plans indicate Central Asian state wants to boost position as supply route into Afghanistan.
Business & Economy, Asia, Afghanistan, Kazakhstan
<p>Watching the defendants enter the Aktau court today, I wondered if one of them would recognise me. I had last seen Roza Tuletayeva in October 2011 when I had come to her home town of Zhanaozen to report on a long-standing industrial dispute between sacked oil workers and the state oil company th
Enbridge Energy is eyeing a major pipeline in Minnesota state, but the project faces fierce environmental opposition.
Environment, Oil spill, Energy
Plunder of Somali waters by foreign fishing vessels could mean the return of hijackings, locals warn.
Environment, Somalia, Africa
Once-thriving northeast factories waylaid by '90s economic reforms as millions of former 'employees-for-life' laid off.
Business & Economy, Unemployment, China
Frustrated by long queues, thousands of refugees register with German authorities struggling with the recent influx.
Refugees, Humanitarian crises, War & Conflict
Armed group says four suicide bombers took part in attack that left four Emirati soldiers and at least 11 others dead.
Middle East, Yemen
Alliance says Russia deliberately violated air space, as Kremlin invites Turkish officials to avoid "misunderstandings".
War & Conflict, Turkey, Russia, Turkey-Syria border, Syrian crisis
We speak to former Israeli Prime Minister Ehud Olmert, and ask a former KGB general about Russia's air strikes in Syria.
War & Conflict, Middle East, Israel
101 East follows the lives of seven people in Nanjing and asks what they think of the direction their country is taking.
Politics, Asia Pacific, China
In a Delhi slum, puppeteers, musicians, jugglers and acrobats try to unite as they wrangle with an approaching eviction.
Business & Economy, Arts & Culture, Poverty & Development
An investigation into the high rate of child sex abuse in Jamaica and the government's failure to protect its children.


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The Design of Arturo H MedranoErotica // Friday, July 12, 2013
Arturo H Medrano is a Brooklyn based graphic designer focusing on book covers, posters, record covers, and print design. He is attracted to world literature, world cinema, and punk from around the world. His wide range of design based collages are both erotically intriguing and entertaining.
Nil Ultra's Tit-Faced JFKErotica // Friday, July 05, 2013
Nil Ultra (Jason Moore) is a man of many endeavors. As a Los Angeles based creative, Moore has his hands in an array of collage, illustration and design work- in addition to being an art director for some pretty impressive clients. His work has tendencies in the bizarre and erotic, using vintage paper goods and periodicals as his primary inspiration.
Matt Gonzalez "Things I Didn't Know I Loved" @ Park Life, SFJuxtapoz // Tuesday, June 25, 2013
Former Green Party Vice-Presidential candidate/ former president of the SF Board of Supervisors and good friend of Juxtapoz magazine, Matt Gonzalez, will open a solo show, Things I Didn't Know I Loved at Park Life in San Francisco this Friday, June 28th. Gonzlaez primarily works in collage, and has shown around SF and interviewed various artists that we have covered over the years, including Barry McGee, Andrew Schoultz, Eva Hesse, and most recently in Juxtapoz, an interview with Berkeley-based politcal cartoonist, Guy Colwell.
Surreal Collages by Alexandra BellissimoJuxtapoz // Thursday, June 06, 2013
This isn't the first time we have seen the works of Alexandra Bellissimo before on our site, but this morning we came across some these collages and wanted to share them again. The Los Angeles-based artist, who has shown at one of our favorite LA spots in Kopeikin, has had written about her work, "Her body of work strongly revolves around the theory of 'making' images instead of simply taking pictures..."
Collage Portraits by Derek GoresErotica // Sunday, June 02, 2013
Born in New York in 1971, Derek Gores is a collage artist based in Melbourne, Florida, and an alumni of The Rhode Island School of Design. Through recycling ephemeral fragments of magazines, labels, data, and assorted analog and digital materials, Gores creates loosely figurative works on canvas, teasing the viewer with fleeting details suggesting the outlines of a body or the pink curves of a woman's lips.
Ben Reyer's Impossible ObjectsErotica // Friday, May 17, 2013
"Women have always been my inspiration," says artist Ben Reyer, "but at the same time they confused me - for me they are impossible objects. We covet them, run after them and love them, live with them, but it hard to understand them." Reyer weaves such themes as the influence of media on society, the horrors of war, religion, and sexuality into his collage work, with the intent of bridging the gap between art and kitsch. His work will be on display at the NENI ART Collective in Vienna, Austria on May 29th, 2013, starting at 7:00 PM.
Collage Art by Ernesto ArtilloErotica // Friday, May 17, 2013
As the art of collage, particularly in the realm of fashion, has become more and more ubiquitous in the last decade, it is consequently more difficult than ever to find truly original interpretations of the craft. Enter Ernesto Artillo, a 26 year-old artist based in Madrid, Spain, whose deceptively simple collage creations transcend the modern cult of the fashion supermodel as timeless works of art, combining ancient Grecian aesthetics of beauty with contemporary graphic restraint and abstraction.
Jock Mooney's Prismatic CollagesIllustration // Monday, April 29, 2013
Multi-disciplinary artist Jock Mooney produces psychedelic pop images and installations, most recently focusing on the aesthetic possibilities of paper collage. Using thousands of hand drawn elements and deliberately spurning the use of xeroxed copies, his kaleidoscopic collages are inspired by a combined obsession for Japanese prints, 60's underground comics, and the Italian gialli genre of filmmaking, the latter heavily informing the often convoluted and pompous titles of his work.
Collages by Steven QuinnJuxtapoz // Friday, April 26, 2013
Belfast-based artist Steven Quinn is a designer and photographer who works as a motion graphics designer. He also makes very cool collages. See a collection of them after the jump...
URS FISCHER @ MOCA, LAJuxtapoz // Monday, April 22, 2013
Spread across MOCA Grand Avenue and The Geffen Contemporary at MOCA, the first survey in the United States of the Swiss-born artist Urs Fischer weaves together some of his most memorable and iconic sculptural works while creating an unexpected landscape in both venues.


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Cascade Mountain Ski Resort Guide
6 am 07 Oct 2015(local time) Weather Forecast for Cascade Mountain at m altitude issued:
Cascade Mountain
Use the buttons below to tell us…
Cascade Mountain Ski Resort Guide
Slope Stats
- Acres of ski:-
- Pistes:27
- Snowmaking:100%
- Halfpipes:3
- Terrain Parks:2
- X-Country:-
- beginner37%
- intermediate19%
- advanced44%
Cascade Mountain in the United States (Wisconsin State) is a medium sized ski resort with 10 ski lifts (8 chair lifts, 2 surface lifts) but it only has 140 metres (460 feet) of vertical descent. Cascade Mountain has 27 trails. Cascade Mountain is best suited to advanced and intermediate skiers and snowboarders. We have no information about the existence of any cross country ski trails at Cascade Mountain. For snowboarders, there are 2 terrain parks and 3 half pipes. All of the trails at Cascade Mountain are covered by snowmaking. The nearest airport is at Chicago and the nearest train station to Cascade Mountain is at Portage.
- Nearest Airport:Chicago
- Nearest Train Station:Portage
- Tourist Office Website:www.cascademountain.com
- Slopeside accommodation:no
- 2
- 5
Announcements & News from the Cascade Mountain ski resort manager
Latest Snow Reportview full snow report
- Issued:7 Oct
- Last Snowfall:
- Snow Depth (upper):–
- Snow Depth (lower):–
- Piste:-
- Off-piste:-
Today's Weather (319 m)view full snow forecast
3650 m
3750 m
3750 m
Resorts close to Cascade Mountain include:
Cascade Mountain Location Maps
(Also see our detailed Weather Map around Cascade Mountain, which will give you visual overview of current and future snow conditions)
Visitor Reviews of Cascade Mountain
Jeff Parriott from United States writes:
Great place to ride or ski, they have state of the art snowmaking. They have a great ski rental provider on site. They have a huge beginner area which is great for families. Cascade, with it's deals on season passes is the place to be in the Midwest.
City Forecasts
Closest to Cascade Mountain
- Sun Prairie, United States43km
- Madison, United States52km
- Fitchburg, United States66km
- Fond du Lac, United States81km
- Oshkosh, United States87km
Surf Breaks
Closest to Cascade Mountain
- Whitefish Bay, United States125km
- Sheboygan, United States138km
- North Point 3, United States139km
- Racine, United States151km
- Zion, United States166km
Mountain Peaks
Closest to Cascade Mountain
- Charles Mound, United States135km
- Mount Hosmer (Iowa), United States149km
- Rib Mountain, United States154km
- Timms Hill, United States221km
- Government Peak, United States359km


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However, because the rate of home births is increasing, and because the academy wants to provide a "professional, supportive interaction" with expectant mothers, Watterberg said the group developed its new policy. The AAP recommends the following factors for a mother considering a home delivery:
Watterberg said midwives often work in teams, and one can be responsible for the baby's care after birth.
"It's important to remember that this is an area of strong emotion. You'll see babies in home births have terrible things happen, but you also have terrible things happen in the hospital sometimes. Women have the right to make an informed decision," she said.
And, if a woman chooses home birth, Watterberg said it's important for the expectant mother to meet the person who will care for her baby after birth. "Meet with that person beforehand. Talk with them about your plans, and see if they have anything to add," she advised.
Dr. Peter Bernstein is a maternal-fetal medicine specialist and director of the perinatal safety program at Montefiore Medical Center in New York City. H
|Copyright©2012 ScoutNews,LLC.
All rights reserved


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A group of 6 of us rented 3 adjoining apartments which was ideal giving us plenty of space. Nicely furnished apartment, great position by large pool and good outlook. The golf course was highly rated by all of us, the new clubhouse did decent food and good bar. Very affordable, rents were low, golf a bargain for Spain and we will be back next year. Incidentally lots of choice of other courses, all rated excellent by our group. more
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Provence Lavender Small Group Half-Day Trip
Recent Photos of this Tour
Schedule details
Select a month to view a calendar of availability and departure details.
Pricing information
Click the link below to check pricing & availability on your preferred travel date. Our pricing is constantly updated to ensure you always receive the lowest price possible.
Morning Lavender Tour
Code: LT1
4-hour lavender tour departing at 9am
USD $57.85Pricing details
Afternoon Lavender Tour
Code: LT2
5-hour lavender tour departing at 2pm
USD $69.42Pricing details
Pricing information
Provence Lavender Small Group Half-Day Trip
- Small-group tour
- Professional guide
- Entrance fees
- Transportation by air-conditioned minivan
- Hotel pickup and drop-off
- Gratuities (optional)
- Food and drinks, unless specified
- Confirmation of this product will be received at time of booking
Traveler Reviews
Reviewed by: oliviaday2010, August 2015
Fantastic tour. Amazing tour guide.
Reviewed by: Julie W, August 2015
Due to the lavender season being early in 2015 a lot of the fields had already been harvested when we were there but our guide, Julien, took us to two fields which were still blooming and beautiful - one of which had a spectacular view of the village of Aurel as a backdrop.
We had a half hour stop in the village of Sault just long enough to buy some lavender based gifts at a better price than we would have found them in Avignon.
As we had not hired a car during our stay in Avignon, this tour gave us the opportunity to see some of the countryside and mountains in the area.


text: Booksie.com health_and_fitness/poetry Publish.Read.Get.Read 2015-10-06T15:11:52-01:00 Mike Defraga(MikeDefraga.com) http://www.booksie.com/parts/images/logo.gif http://www.booksie.com/health_and_fitness/poetry/rss/2.0/popular/1 Booksie Lime http://www.booksie.com/health_and_fitness/poetry/shazzie/lime 2015-09-18T02:49:18-01:00 Lime are made to treat people not to poison. Never use it if our intention of being evil. Shazzie http://www.booksie.com/shazzie Wall of Death! http://www.booksie.com/health_and_fitness/poetry/momobeena/wall-of-death 2015-06-28T16:48:39-01:00 This comes under health & fitness I guess, right?! Momobeena http://www.booksie.com/momobeena Stretching http://www.booksie.com/health_and_fitness/poetry/rich13/stretching 2015-06-13T17:18:35-01:00 I have tried my first real stretch class. Many people have told me for years that it is good for you. I am listening now. rich13 http://www.booksie.com/rich13 Can't breathe http://www.booksie.com/health_and_fitness/poetry/kjhweir/cant-breathe 2015-03-30T17:27:12-01:00 Panic attack Kjhweir http://www.booksie.com/kjhweir WHY http://www.booksie.com/health_and_fitness/poetry/houssein_yassin/why 2015-03-26T15:17:04-01:00 causes of drug addiction Houssein Yassin http://www.booksie.com/houssein_yassin Hey there bipolar depression http://www.booksie.com/health_and_fitness/poetry/fab/hey-there-bipolar-depression 2015-03-25T12:13:09-01:00 A poem outlining the struggles of mental illness. Fab http://www.booksie.com/fab Purple Day http://www.booksie.com/health_and_fitness/poetry/jessgs/purple-day 2015-03-24T12:36:52-01:00 In 2 days' time it will be "Purple Day" A day devoted to raising awareness of epilepsy, and destroying the stigma around it. Since I was 11 years old, I have had epilepsy and now, I am determined it will not have me. Please help spread awareness of this common neurological condition, and help us find a cure, faster. Jessgs http://www.booksie.com/jessgs World Alzheimer's Day 2013 http://www.booksie.com/health_and_fitness/poetry/abyskaria/world-alzheimers-day-2013 2014-12-16T16:56:43-01:00 Your devotion is this life. If you forget this moment how far will be every blessing. Yet you find happiness in a vacuum thought of a empty mind. Your time with them is the cure. God created this awareness as a time where one wish would be a healing cure in the human adventure on this planet. Thank everyone who let a helping hand for this awareness. Your word is the true blessing. :) Abyskaria http://www.booksie.com/abyskaria World AIDS Day 2013 http://www.booksie.com/health_and_fitness/poetry/abyskaria/world-aids-day-2013 2014-12-16T16:56:43-01:00 From the bottom of my heart, if heaven grant one healing cure for this situation, we might win the greatest battle for every life lost. Today we promise that those who live with this disease may not be lost in sorrow or fear. Let us together fight this stigma called AIDS. :) Abyskaria http://www.booksie.com/abyskaria World Cancer Day 2014 http://www.booksie.com/health_and_fitness/poetry/abyskaria/world-cancer-day-2014 2014-12-16T16:56:43-01:00 In life for the greatest battle to be won, let us support dimensions to unite everyone in all extremes of society who now live with Cancer. All ingredients of this day stand before the wall written with their spirit. Let us appeal to the supreme for a cure as expression count. :) Abyskaria http://www.booksie.com/abyskaria Motivation http://www.booksie.com/health_and_fitness/poetry/luvyourstuff/motivation 2014-11-11T14:34:29-01:00 Motivation Poem Luvyourstuff http://www.booksie.com/luvyourstuff 'Here My Love Two Dopamine" http://www.booksie.com/health_and_fitness/poetry/nuffzed/here-my-love-two-dopamine 2014-08-29T15:36:35-01:00 Nick Thomas. 2006 (Sundowners at Mouille Point Cape Town after watching a performance of 'Swan Lake' ballet.) Dopamine in Parkinson's disease Nuffzed http://www.booksie.com/nuffzed Selbiologie http://www.booksie.com/health_and_fitness/poetry/phwlofthenow/selbiologie 2014-08-26T02:23:44-01:00 ///AFRIKAANS/// A poem inspired by the absolute struggles of cell biology and how terribly boring it is. Phwlofthenow http://www.booksie.com/phwlofthenow COLONOSCOPY http://www.booksie.com/health_and_fitness/poetry/colinb/colonoscopy 2014-07-07T02:50:29-01:00 COLONOSCOPY Colinb http://www.booksie.com/colinb Rehabilitation http://www.booksie.com/health_and_fitness/poetry/connorand1996/rehabilitation 2014-05-07T17:18:54-01:00 A poem about the world's most common dependence. connorand1996 http://www.booksie.com/connorand1996


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Jay Z, Beyoncé, Prince, and More to Play Tidal Benefit Concert Next Month
It'll be livestreamed for free!By Dee Lockett
It'll be livestreamed for free!By Dee Lockett
The alt-diva mashup provided some surprisingly good harmony.By Greg Cwik
Featuring Arrow Benjamin and a music video, too!By Sean Fitz-Gerald
They also did "History of Rap 6."By Sean Fitz-Gerald
Middle finger to the competition.By Dee Lockett
Your hump day pick-me-up.By E. Alex Jung
Taylor Swift leads all nominees.By Nate Jones
They had Johnnie Walker on the rocks.By E. Alex Jung
Sony isn't having it.By Dee Lockett
2015's best meme.By Dee Lockett
Yes, you can.By Nate Jones
We have some screenshots!By Dee Lockett
Tulane, you are so lucky.By Dee Lockett
Secretly, of course.By Nate Jones
"I remember slumber parties after my divorce, when we watched old movies and ate a lot of ice cream."By Dee Lockett
By American Idol's Todrick Hall.By Dee Lockett
There will be riots ... or at least a lot of illegal downloads.By Sean Fitz-Gerald
Following pop music right now is exhausting.By Lindsay Zoladz
This is not a drill.By Greg Cwik
Thanks, Kelly Rowland.By Greg Cwik


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I booked a week in a one bedroom apartment at Les Maisons de la Mer for myself and my husband for September 2012. I had read mixed reviews on TripAdvisor , but the bad reviews all seemed to be 2009 and earlier, reviews seemed more positive after 2009. I wasn't expecting luxury, we knew that it was fairly basic, budget accommodation, but we didn't want to be on a large all inclusive hotel complex, especially as these seemed to have had bad reviews recently. What I didn't expect was just how bad the apartment was that we were put in.
We arrived in the early hours of the morning after a badly organised shuttle transfer with Amit Transfer Services, which took longer than the flight from Newcastle! The apartment number 639 was terrible. We have stayed in a lot of budget accommodation in the likes of Gambia and India and have never asked to be moved before. This was the worst accommodation I have ever been to. We're not fussy people but the bathroom in the apartment was especially bad. The toilet was disgusting, the rings on the shower curtain were all rusted, there was mold and rust around the bath and sink, the plughole in the bath was dirty and rusty. In fact the whole apartment looked like it had been abandoned. The porter who took us to the room opened the patio doors to show us the balcony and the handle fell off and we then couldn't close the doors at all, they stood ajar all night. The kitchen needed a complete overhaul.
We went straight back to reception and complained. We were told they were fully booked and could not move us that night, but to come back in the morning and ask again, so we had no option but to sleep there that night. We didn't unpack!
The next morning I took photographs around the apartment and we took our cases to reception to complain. The man at reception wasn't convinced at first, even when I said that the balcony doors didn't close – he just said that, as we were on the first floor, security wouldn't be a problem. But he couldn't really argue with me when I showed him the pictures I'd taken of the bathroom, especially the one of the toilet. He said he didn't have any other rooms straight away but we could leave our cases and come back later. We said we would wait in reception. I think this did the trick as he got on the phone and within the hour told us he'd found us a different apartment, but in the 'new block' which also had air conditioning, but was a smaller studio apartment.
Les Maisons de la Mer is the complex near the beach and mariner, Les Maisons de la Jardins are the apartments around the fountains and the fun fair across the road from the mariner. We were taken across to an apartment in the 'de la Jardins' area.
This second apartment number 1070, was more in keeping with what I'd expected, still basic accommodation, but a big improvement on the first apartment, plus it had air con which the first didn't have. We would have had to hire a fan if we hadn't had the air con as it was really hot at the time of our holiday.
My only reservation with the second apartment was that we overlooked the funfair, but I thought that this would most likely close around 11pm, so we wouldn't be too affected by this. How wrong I was! We decided to stick with this apartment as we weren't too sure what the alternative would be.
Friday through to Sunday they had extra entertainment at a stage area on the funfair for the Tunisians and Libyans that were holidaying in Port el Kantaoui. They must have been able to hear the female host down at the beach, it was so loud and went on until 1am in the morning. Luckily the other nights during the week we just had noise of the funfair, which was still quite loud but not as bad. Our balcony overlooked the bumper cars.
The pool at the back of our apartment was overgrown and abandoned, there was a pool across at the Maisons de la Mer complex which looked very nice but, as it was full of kids, we spent most days on the beach.
On our last day, we weren't flying home until very late at night and had to check out of our room at 11am. We asked if there were any facilities we could use to take a shower before going to the airport. We were given the keys to another apartment that was still on the 'de la Jardins' part of the complex but overlooked the fountains. It was a one bedroom family apartment with a bathroom and extra toilet, plus 2 single beds in the living area. This was again an improvement on the second apartment that we stayed in but the air conditioning didn't work. Also I noticed that there was only air con in the living area of the apartment and not in the separate bedroom.
The general location of the Maisons de la Mer and Maisons de la Jardins was really good, central to everything, but I would not recommend these apartments as it's a lottery what standard of room you get and whether it will be in a quiet part of the complex or a very noisy location. Looking around the area you can tell from the outside of the apartment blocks that some have been recently refurbished and others are in dire need of attention. I would not stay here again!
- Also Known As:
- Les Maisons De La Mer Hotel Port El Kantaoui