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Looking Ahead after the Approval of...
Proposed Changes to Pharmaceutical Carcinogenicity Testing...
For-Profit Developers, Nonprofit Academic Labs Challenge...
Developing High-Throughput Compound Screening Methods for...
The France-based agro-biotech firm Limagrain acquired a nonexclusive commercial license to use Cellectis' I-Scel meganuclease technology in the development of new plant varieties. The agreement follows a five-year research collaboration between the companies to generate new agricultural products with this platform.
Limagrain's commercial license marks the start of formal product development using the meganuclease tools. This will be carried out by Biogemma, the plant biotechnology company in which Limagrain has a shareholding. Resulting products will be commercialized by Limagrain and other Biogemma shareholders.
"This agreement is important because it complements our portfolio of technologies to develop genetically modified plants allowing the ability, among others, to assemble multiple traits of interest in a single plant," comments Pascual Perez, Biogemma's CEO.
Cellectis' genome engineering and meganuclease technologies are primarily being exploited for human therapeutic and biotech research applications. The company says it aims to forge wider agricultural biotechnology partnerships in a global market estimated to be worth over $10 billion annually and growing at some 15% every year.
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December 30, 2008 in City
Snow, wind on the way
National Weather Service radar images show the next in a series of winter storms moving into the lower Columbia Basin this evening and headed toward the Inland Northwest.
This storm is expected to bring less snow than the hit the region took on Monday, but it's also packing some strong winds.
Another potentially stronger storm is due in by New Year's Day evening with a threat of 6 or more inches of snow and winds strong enough to cause blowing and drifting snow.
Forecasters said that Spokane had an unbelieveable 56.5 inches of snow in 13 days, more than the normal amount of 48 inches in a full winter season.
The winter storms have claimed at least one life of a woman hit by snow falling off a roof in Rockford.
About two inches was forecasted for Spokane through the morning with more in Coeur d'Alene. A winter weather advisory was posted in advance of the storm by the National Weather Service. The region-wide forecast called for 2 to 4 inches.
East wind gusts up to 30 mph are expected tonight, with winds shifting to the southwest after a cold front passes early Wednesday. Gusts Wednesday could hit 50 mph.
The region should see a break in storms Saturday and Sunday before another moist Pacific front moves onshore Monday.
After that, computer forecast models suggest a change in the pattern toward moist, but possibly milder weather.
At 6 p.m., the leading edge of the storm was showing up on radar images in the lower Columbia Basin and heading northeast toward Spokane at a speed of about 50 to 60 mph.
Late New Year's Day could bring the possibility of blizzard-like conditions, said forecaster Kerry Jones.
Relatively warm air is expected to surge northward Thursday ahead of a deep surface low expected to form off Vancouver Island. As the warm air moves in from the Columbia Basin, any precipitation could be a mix of rain and snow, Jones said in a weather briefing today.
Snowfall this month so far has reached an estimated weight of 15 to 20 pounds per square foot, Jones said in the briefing.
Most homes are designed to withstand loads of 50 pounds per square foot, engineers said.
On Monday, wind-blown snow stranded at least 18 motorists in rural Spokane County who had to be rescued by a volunteer search and rescue organization called the Winter Knights, county officials said.
The state of Washington brought five plow trucks from western Washington to the Spokane area with 10 drivers to provide 24-hour service for the coming week. The Department of Transportation has agreed to help Spokane County open its drifting roads.
A snow blowing truck from the Washington Air National Guard was deployed to help open drifted-over roads, said Martha Lou Wheatley-Billeter, county spokeswoman.
The county has also contracted for 14 privately-owned truck plows with drivers.
Elsewhere, crews were reportedly making progress in opening main routes and were returning to residential streets for yet another pass.

subset: commoncrawl


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Lou Malnati's "Chicago"
While driving so many hours for pizza sounds crazy to some, I'm crazy enough. Hearing who the "Who-Has-The- Best-Deep-Dish-Pizza" debate in Chicago is entertaining. After a pretty extensive conversation with fellow writer Paul Martinez, I was sold on Lou Malnati's. He had me daydreaming inside the car on our way there as he spoke about everything from its texture to its unique sauce. When we finally arrived at our downtown location at about noon, we found the place jam packed with the lunch crowd.
The sudden smell of this pizza had me thinking deeply about how this experience would be. We enjoyed a short wait for our order – an original deep dish pizza. Make no mistake, this deep dish was not thick bread based pizza with tons of toppings. Lou Malnati's is different for all the right reasons. The crust is thinner than most which makes for a special crunchy and buttery outer core. The sauce is indeed the kicker: not too strong but with the perfect hint of acid, almost citric. The high quality pepperoni and Wisconsin cheese makes it all come together. Truly this pizza was one of the best I have ever had. I tried nothing else, but then, why would I? After this breath taking pizza eating session, it was only fitting to take two pies back to Miami with me. Not from here? Take my advice: have it shipped. The Lou Malnati's experience has made me a firm believer that Chicago's version of pizza edges NYC. Deep dish rules!
Pincho Factory
Interview : LeJuan James
Here's my interview with Instagram Celebrity Le Juan James exclusive on Inaxxs.com
Juan Atiles is better known to his close to 400,000 followers (and counting!) in the social media world as LeJuan James, in honor of his basketball idol, Lebron James. Born of Puerto Rican and Dominican descent, the young comedic actor made his atmospheric leap into the public eye with gut twisting skits portraying Hispanic culture and its community. Inaxxs' own Manny Garcia had the opportunity to sit down with LeJuan James to find out what made him drop everything – school, work, etc. – to do it for the vine.
Do you remember the moment you realized that using your phone to make videos was bigger than something that was just cool to do?
LeJuan James:
I always remember that. I've been able to change my life, not only for myself but for my family. I was able to put myself in a position to be successful off of social media. Honestly, I got started on Vine. I was playing around. It wasn't something that I was thinking about doing. I was a full time student/full time retail manager. I wasn't really thinking about it. I got my family involved and people started gravitating to it. When I started seeing that I was a couple of weeks in and then a couple of months, the type of energy and attention that it drew, that it forced me to dedicate my life to entertainment. I had to leave my job and school. I had to drop everything. Everyone I knew was looking at me crazy. I had never been the type of dude to take risks, but I took a leap of faith and everything is turning out really good for me and I'm really excited.
Give us an inside look at the typical day in the life of LeJuan James. You made a radical jump – a leap of faith as you said. What's the inside scoop? Do you write something up to post on Instagram?
LeJuan James:
To be honest, my days are really laid back and chill. There isn't a routine or schedule for my content. I feel the real creative content comes out when it isn't forced and it's not over-thought. I can be watching something and get to thinking about it. For instance, I just happen to be scrolling through the internet and saw The Simpsons and thought about how funny it would be if I reinvent it from the Spanish culture point of view. The content comes out much better when it's not overdone. I make sure that the content is relative to everyone and has humor. The day in the life of LeJuan is chill.
With everything that has happened for you over the past year with Vine, are you 'programmed' now? Is everything you see and experience something you immediately translate into an Vine video? Do they come at any moment?
LeJuan James:
Yeah, my body and my mind is programmed. I mean, me personally I have to come up with content everyday. I'm not stressing over it. I don't mean to sound cocky, but it's the confidence in me that I know I'm going to deliver something good that the audience wants. I see my following and how fast it's growing. I pay attention to what the public wants and the perception of what to humorize.
I'm very conscious of my image, the things that I do, and what people are saying. I study social media as if it were a job. It's a science to me. I have particular times to post, particular passions, and certain things I want to talk about. It's a business at the end of the day.
MG: Let's talk about the phone. Everyone talks about how funny your videos are. I thought it would be dope to talk about the important your phone is. I have a two part question. 1. How important is your phone and have you change your phone? and 2. If you talked to a phone company, what would tell them to change for people to better interact with social media?
Lejuan James:
Cell phones are extremely significant. 99.9 percent of the population cannot function without their phone. When I was growing up we didn't have the phones that we've have now. I see kids in school with the new iPhone 6. Generations are evolving and the phone is part of their lives. I have been able to impact hundreds of thousands of people through a device that was originally created to communicate from Point A to Point B. It's an integral part of my life and everyone else. As far as companies helping to better interact with social media, third parties have done this. Twitter, Vine, Snapchat, etc. These third party platforms have given me the opportunity to get ahead. This is America and this is a place where you can make your own dreams. I mean, I wake up everyday and feel blessed because I have been able to take advantage of opportunities through a phone. There is so much interest in cell phones that it gives the public more interest in me because all of my work is through a phone. You're always connected to LeJuan James. Whether it be Instagram, Vine, Snapchat, and now I'm working on some stuff for YouTube. You just have to make sure you're marketable. You have to continue to evolve yourself.
Tell me about your videos. I checked out your YouTube and you do a pretty dope job at acting. What's so cool is that it relates past Puerto Rican and Dominican culture. They're hilarious and the comedy is clean and I was thinking that there are so many out there who do things on YouTube that is really edgy. Why did you make the decision to keep it clean and so far what has it shown you?
LeJuan James:
I know I represent Hispanics. There are stereotypes and I want to break those barriers. I don't want to be another stereotype. I want to show that Hispanics can be educated and progressive, be about their families, and want to get ahead. Specifically in the comedy department, some feel like they have to curse to bring humor, degrade females, or to talk about drugs and crime. At the end of the day that's not what I represent. A big portion of that is the way I was brought up. I refuse to let society change my mindset. I get people from all walks of life being able to identify with my work and I'm very proud of that. That's what resonates with me and there's no dollar amount that can change that.
Let's talk about the pressure. Is there any to constantly bring out content that is relevant and funny?
LeJuan James:
I try to live one day at a time. I know many people have high expectations of me, but I just focus on the next thing.
What is the future of LeJuan James beyond just doing Vine videos? I know you done some hosting of parties, done some stuff with Univision Orlando. How do you see LeJuan James five years from now?
LeJuan James:
As far as the future, we have a lot going on. I invite people to check me out on all social media platforms. It started out with the videos and now we've been able to branch out to other platforms. I'm right now on a TV station every Sunday, working with Telemundo on some things, and quite a few other things. The sky is the limit. I don't want to just label myself. I'm an entertainer. I want to be in movies and TV shows. I want to be able to do everything in my ability. It's a year in October that I left my job to go on this voyage and I'm looking forward to what's ahead.
I know that family is very important to you and plays a very vital role in your life. Hispanics are pretty private about their lives. Give me a word that describes each one of your family members that are included in your videos.
LeJuan James:
Everything that has happened to me and has got me to where I am now is my family. When you see you videos, you see the bond. I have a traditional family that really loves each other. Without their unity, I would never be even where I am now.
MG: What team on your own? iPhone or Android?
LeJuan James:
Listen, I'm on both. I shoot all my videos on iPhone because the video editing is better. I use my Android to talk on. I win all the time. (laughs).
Source: Inaxxs.com
Cozy Corner – Memphis
While on a trip to Mississippi, I was clear on getting BBQ. In Miami, awesome BBQ is hard to come by or at least is difficult to find. Cozy Corner was the place I was told to go to. After watching a history video on the place, I wanted to feel the same thing I saw on the video. When you arrive to the Cozy Corner it's pretty clear that you're in the hood, which I love by the way. Yeah, I'm from the hood, enough about the restaurants area.
If you're looking for a serious decor, cool lighting and nice set up this isn't for you but if you want finger licking BBQ, than this is the place. We arrived on a Saturday afternoon to find the owner sitting table side talking with customers and just helping all around. You could tell that many of the customers are regulars as they speak like family.
We couldn't help ourselves so we ordered way too much food like rib tips, rack of ribs, and chicken. The portions are huge. The BBQ sauce is a little sweet but counters well with the deep smoky flavor of the meat. Service is OK, a little un-personal, sort of felt like they knew we were from another state.
The BBQ is moist, soft, smoky and ohh so succulent. Yes, you can lick your fingers now. If you can get pass the not so great decor and all your worried about is amazing taste than you hit a home run!!!
* A small tip for all my sweet tooth loving people, try the banana pudding. It's so good, simple yet done right. We took 5 servings for the road which never made it to Miami. Cozy Corner gave us history, not so great service and serious good BBQ. Don't worry about the neighborhood, you'll be fine. Stick to the food, you'll be safe there.*
Glazed & infused Chicago
When I arrived at Glazed and Infused in Chicago, Illinois, I predicted I was going to get some serious fried dough. It was a cold Saturday morning as I arrived to a hip doughnut shop with great decor and a serious amount of small samples. You can actually try 80 percent of the doughnuts before you buy which really makes a serious first impression.
As I gazed at the vast variety of options, I thought of taking them all but realized that wasn't going happen. I kept it simple and tried their signature maple bacon log doughnut, which was good. It's not to sweet but has a solid balance of sweet and savory flavor, making it a great doughnut. The whole time there, I was tempted to try these huge home made marsh-mallows.
The staff is very friendly and made me feel at home. They gave great info on the doughnuts and the history of the shop. There's something about Chicago's cold winter weather with a great cup of coffee, and a huge glazed birthday doughnut from Glazed & infused, it's as good as it gets. Be ready to see working people in the area. Parking is limited which was the only down side. Tips for newbies, do what I did, get someone to drive you up to the location and wait outside while you pick the fresh,glazed ,fried goodness. Glazed and Infused has really made a new fan, especially with all the amazing doughnuts I didn't try.
See you soon Chicago!
Chattahoochee Coffee Company (Atlanta)
When you say coffee house, few will ever think, nice, sunny, and river side location can be mentioned in the same sentence. Chattahoochee Coffee Company in Atlanta, Georgia is not your normal, overcrowded, free Wi-Fi and hip location. It's the simple things in Life; a nice cup of coffee and river side.
First let's take a look at the location. Inside a private apartment complex sits this small but unique coffee house. Walk up the stairs to get a coffee and head outside to an amazing relaxing experience, with lounge chairs, rocks or even a mountain trail if that's your cup of coffee. The Chattahoochee River is feet away from the coffee house and it just makes the fact of getting a frappe or hot coffee something exciting and blissful at the same time.
The Service is friendly and knowledgeable. No big machines, just the classic real way of brewing coffee. Prices are fair, coffee is good, and parking is easy with in house staff telling you where to park which is nice. The beautiful nature background is what easily sets this place apart. You have to see it to believe it. Have a nice cup of coffee on the rocks and the riverside are things you will never forget. Coming from Miami, it was a new and refreshing in every sense of the word. Or coffee bean in this case.
Latin House Grill
A Cuban dude from Hialeah starts a food truck and in less than a year has one of Miami hottest eateries.
Latin House Grill is the perfect combination of Cuban and Mexican like you never tasted before. I must admit from the start, LHG is never open on Mondays (Which left me bummed out the first time I attempted to show up because I didn't look at the website to see what's up.) "Who cares, they said the food is good." I decided to take the 25 minute drive from my house to show up at the House that has the best burger! I made the wrong choice to show up when there was to big of a crowd.
Via "Burger Brawl 2013": "LHG has way more than burgers, tacos are also on the menu and do not disappoint."
The first thing on the menu was the sneaky nachos. The Sneaky nachos are thebomb.com! First you pick the protein, and then sit back and enjoy the Flavor rollercoaster. I picked the care asada sneaky nachos, they are not your regular nachos. They have tender pieces of carne asada with in house cheese sauce, Pico de Gallo and this white cheese sauce makes it all better. There is no overly melted cheese to cover up chips that over power the protein, just a blissful amount of carne with 2 cheeses to get you started correctly.
Looking around the table I began to pick other options. Be very clear, the Vaca frita at LHG is some of the best I've had. Either there's a mom in the back putting her elbow into the flavor bowl or I just can't describe what you're getting. It had a little bit of a bitter orange taste and something that was marinated for a while, either way it stands alone. The lettuce wraps with chorizo are also really good. Lastly I had the Champ Burger (which recently won The Burgie awards), it has the perfect heat to get you going. LHG is very good all across the board and if you get the waiter who's a part time comedian ( John Q ) you can get a few laughs free. I'm in Mad Love Heaven! Till we meet again LHG!
Heirloom BBQ (Atlanta #Foodiereview)
Heirloom BBQ is definitely a hidden gem . The Korean BBQ spot, hidden next to a supermarket in Atlanta, turns out amazing brisket, ribs and so much more. If you want to eat there get ready to stand as they have an outside patio section. I'm sure once you get a bite of anything on their menu the urge to sit will go away in seconds.
Based on reviews from the locals, I had to try their Korean BBQ sandwich. The idea of the sandwich got my taste buds going. The sandwich consists of kimchee, BBQ pork chunks and a nice brioche bun. The spicy pork with the mix of not so hot kimchee, a hint of sweetness, was a great balance. Every bite of the sandwich has a burst of serious flavor.
Brisket was next on the menu. They deliver a nice portion of smoky, soft, tender brisket with so many beautiful black ends. Man it's like Gold I tell you. The brisket stands alone without anything, it's almost like candy. I made a huge mistake by not ordering more.The Brisket is a must have.
Heirloom BBQ is affordable, fast and delivers top notch BBQ. If you're looking for something a little different when you come to Atlanta this is the place you need to visit. The locals know the good stuff, Heirloom BBQ might not have the biggest location but they aren't lacking the big flavor!!!!
New Year's resolutions, why don't they work ?
It's the New Year, and millions of people across the world are excited about, yeah you guess it, their New Year's resolutions. It's that one moment we promise ourselves and others the compromise of change and sacrifice. And even though I am all for self-improvement, and long impressive lists, there a few things we need to consider before we set ourselves up for failure. According to University of Scranton, Journal of Clinical Psychology, there are "45% of Americans who make New Year's resolutions", and it is only "8% who actually keep them". That's a real disappointment, so half of America gets excited about a list filled with promises of improvement and change, yet our commitment doesn't make it past the 6th month.
So why is it so many of us start off with a list and end up in front of our garbage cans ripping our goals into smithereens? I believe it's because we set ourselves up with impossible expectations. Be honest and sincere with yourself, you know what you're capable of and you know what's just ridiculous to expect of yourself. So when creating your New Year's resolutions be considerate of what is actually achievable. Some might beg to differ, and argue that New Year's resolutions are supposed to be filled with the impossibilities that need to be made able, yet I feel that being unrealistic with ourselves is causing us to not even try and give up after a few months.
Another reason is because we should set ourselves up with daily resolutions rather than wait a whole New Year to even start considering self-improvement. We should all be changing on a daily basis for the best. If you want lose weight or eat healthy its best to start today, right now. Consistency is also very important. Research has proven that it takes 21 days to form a habit. So, if you want to get rid of a bad habit, apply the good one for 21 days and your set! Now, there's a difference between habit and addiction. A bad habit is negative behavior pattern. Some examples are procrastination, fidgeting, overspending, nail-biting, and so forth. Now addictions are continued repetition of a behavior despite adverse consequences, or a neurological impairment leading to such behaviors, in that case you should contact a professional. In addition, I believe accountability is needed to maintain our desired goals. Have friend or someone you trust to be your source of accountability. There's nothing more uncomfortable and confronting than to have to own up to the fact that for this week you, totally didn't meet your goals. But the point is not to feel defeated but to be reminded to stay focused and push you through it. This person should have qualities of motivator and most of all believe in what you're trying to accomplish. And last but not least don't try, just do, you're worth it! And there it folks, I hope this help us all to not just start another year successfully but actually be consistent with our success and reach our goals.
Source: Maricel Romain


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i have 2 different apps i want to do,i dont want to discuss to much about them but one is an organiser app of some sort and the other is to do with a music app.
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Re: Hacking Team?
Not sure whether psychotic attack or trying to make sense?
12017 posts • joined 3 Jun 2008
Not sure whether psychotic attack or trying to make sense?
Insisting on a warrant is today likely to be decried as "unfair" and possibly "inefficient".
Free donut crumbs and a disused pepper spray can .. now on your phone!
Unless you keep it simple.
So, even if they did create a convincing competitor to Youtube, their legal content would be competing with Google's illegal content.
Amazingly, this is exactly Big Music's old argument of "Imma being robbed blind by the Interwebs" from the 90s, just with different actors.
That would be called bootstrapping.
Scoot Aaronson: PHYS771 Lecture 19: Time Travel
"The Timehack Funding Bill is passed. The system goes on-line August 4th, 2017. Timehack Control begins to experiment at a geometric rate. It manages to create a closed timelike curve at 2:14 a.m. Eastern time, August 29th, or a few seconds earlier depending on your point of view. In a panic, they try to pull the plug. Too late. Minds of the the Aperture Science research team are taken over in 5.1 seconds. The rest of the connected world follows soon after. Only techno-refuseniks, hippies and stuckists survive."
Not enough attention goes on people and this has been the industry's biggest failing, says Professor Woodward.
FAIL. I will believe in that approach when "security stories" start appearing right next to the stories about the latest developments in Monaco's monarchy. In the same mag.
The UK government has shown some inclination towards improving public awareness.
FAIL. The UK government has shown some inclination towards spending taxpayer money on quixotic schemes.
In January it launched the Cyber Streetwise campaign. .... Little is known of the initiative's actual impact.
Shall I repeat? LITTLE IS KNOWN. And this is not going to change. Nor will anything be changed.
Simon Placks, head of cybercrime investigations at EY, however, has a very good statement:
An intrusion is not an illness that can be prevented with good cyber-hygiene.
On the other hand, you may just be a target of opportunity. There is not much you can do against that except have a dedicated team working on reducing the attack surface, day-in and day-out.
According to Stewart Room, barrister and solicitor specialising in data protection, that legislation is required to improve the fight against online crimes, is an indictment of the efforts of non-public organisations. ... "If the hacking problem needs regulations to improve cyber security, then as a matter of simple logic the medicine has to be strong, because the market has utterly failed."
The failure is you, Mr. Room. Show me how this is supposed to work. No-one even knows what the medecine is and whether it exists in the first place. "The government" unable to find its own arse in the best of times, sure does not - nor can it issue valid regulation in this case. It may even be the perpetrator in a serious percentage of cases.
Note that "Regulation" is a term that encompasses concepts with differring meaning, so whenever I hear "Regulation" with no further qualification I know that someone is starting to play with words and tries to access the hindbrain. Note how "Airline regulation" [which is about process control] is VERY different from "Stockmarket regulation" [which is about fog generation for the hoi-polloi] and "Healthcare regulation" [which is about entrenching vested interests and giving oneself a progressive do-gooder sheen]. "Regulation" is not a nugget of compressed wisdom from the Gods that will magically result in shifting the no-longer-so-free market to generate secure software affordable by everyone. At best, it will do nothing. Except cost a few millions in legislative soul-searching.
What planet do these fantasists live on?
The same planet as the downvoters. I don't know how any of this makes any sense whatsoever. I always buy wine from an actual shop, preferably during a show & taste extravaganza.
And I got to say, not many french wines excite me.
Shurely the practice of extreme shark jumping has now reached the level marked "biblical" in a fat felt marker pen?
If the saleability of french wines du terroir (not to be confused with terreur) is actually dependent on the non-existence of new top-level domains, however ill-advised these may be, better dump that shit into the french campagne.
"All right. And don't jinx me!"
CERN were the ones who first suggested that the anomalous behavior of antiparticles could be due to antigravity or substantially weakened gravity.
Oh yeah? Citation needed or you are full of it.
CERN would never be "the first to suggest" unless we are in a Hollywood thriller.
anomalous behavior of antiparticles
What "anomalous behaviour" is that?
Evgene Podkletnov
>Still doing Podkletnov
So many Z bosons!
particles like electrons get their mass by coupling to the Higgs field, which is really exciting
Personally, I do think this is a massive advance!
"FIPS 140-2 rating"
1) What level
2) Where is the "cryptographic module"?
3) Amazingly, it is very often possible to hack around the cryptographic module.
those accreditations do actually mean something
SNORT. They mean that money was pushed to "consultants" to obtain an accreditation. Basically, a feature for people with lots of money, pointy hairs and a stamp fetish.
And then: OpenSSL is accredited!
Did I mention this? It used to be in the standard: "Deterministic Random Number Generators, Number 4: (Removed) Public Key Cryptography for the Financial Services Industry: The Elliptic Curve Digital Signature Algorithm (ECDSA)"
And from the this presentation, we bring this pricelessness. Yep, ECDSA never worked in OpenSSL in the first place.
But wouldn't the FIPS validation have caught the fact that the OpenSSL implementation didn't work? Not only the original validation but many subsequent validations have successfully passed the algorithm tests ... several hundred times now. That's a lot of fail ... the FIPS 140-2 2 validation testing isn't very useful for catching real-world problems ("Flaw in Dual EC DRBG (no, not that one)", Steve Marque)
Say no more!
£250 if you account for "inflation".
Upping pension payouts? Where do you think you are?
That's life. Live with it.
No, I won't live with it. F.U., go back to your fly-by-night-fresh-from-uni-it-compiles-ship-it-no-money-for-software-assurance coding horror.
But in that story, this turned out to be a Good Thing.
Maybe you need a device that wakes you up over the Internet?
Yeah, afterwards everyone is like "WHO LET THE DOGS OUT", "IT WASN'T ME" and "SIT, ISIS, SIT!!"
"the equipment was taken out of the cat; the cat was re-sewn for a second time, and lived a long and happy life afterwards"
Scratch Monkey levels of Unbelievable reached!
Given that ... I would say that D-Wave do indeed have a quantum computer
Although your biggening up is noted, your criteria for QC-ness are frankly lacking in salience.
You are of course free to send your own money to D-Wave (far be it from me to have a negative opinion on that), but please don't go all "we this" and "we that" here.
So basically, bad code causes slowdowns?
No, because there is no code.
It's a "quantum annealing" machine, which is something like a cooling metal, only with configurable strengths between the configuration elements (think analog computer doing neural networks or spin glass annealing), and with more quantum sauce.
I also notice that there are two Google Guys/Gals in the list of authors:
> Troels F. Rønnow - Theoretische Physik, ETH Zurich
> Zhihui Wang - Department of Chemistry, University of Southern California
> Joshua Job - Center for Quantum Information Science and Technology & Department of Physics, University of Southern California
> Sergio Boixo - Google, 150 Main Street, Venice Beach, California
> Sergei V. Isakov - Google, Brandschenkestrasse 110, Zurich
> David Wecker - Quantum Architectures and Computation Group, Microsoft Research, Redmond
> John M. Martinis - Department of Physics, University of California Santa Barbara
> Daniel A. Lidar - Department of Chemistry & Center for Quantum Information Science and Technology & Department of Physics, University of Southern California
> Matthias Troyer - Theoretische Physik, ETH Zurich
Google also issued its own response to the Troyer paper, noting that in its tests the firm is getting computational speeds of over 35,500 times that of conventional computing systems.
Yeah, but is that speedup outside of the error ranges? And what problems are they solving? Movie recommendations?
without decent electronics
That's the price of a whole sensor!
No need to launch suborbital menhirs about this.
Solid is very reliable, very powerful and be can stored reliably too (which is why anyone doing world destruction as if he wanted to win has solid-fueled ICBMs). It cannot be turned off once lighted, does the shakey-shakey of the rocket and is a bit difficult to handle in production (chinese fireworks manufacturing difficult, only larger and with nastier chemicals). If the rocket becomes too big, you run in assembly problems and may end up doing unadvisable things (like using flakey O-ring architectures) which you will regret later.
Nobody even ever found out who shortened United Airlines shortly before 9/11.
Indeed. I hear some HST currently push money to the NYSE to get notified earlier than the rest of the world about what's rolling down the pipe. This ain't called doing business.
From Krebsonsecurity:
"So do you think this is legit, or is the guy trying to scare us?" the IT director asked in an email to KrebsOnSecurity.com, agreeing to discuss the incident if he and his company were not named. "He has sent me the logs for the connections to the infected server. I checked the firewall and am not seeing any active connections."
The hairs, they are pointy!
Henninger did not know if the hack was reported to the Securities and Exchange Commission [probably sleeping anyway] or FBI and noted that funb would have little incentive to do so.
So who is funb? The board of fun?
The unnamed company, which initially laughed off the disclosure,...
They were still on the way to the bank. Probably with your money.
No. No-one.
The path of clue-do is its own reward!
Professor Jake begs his compatriots to remain calm. The situation is being monitored!
That is not dead which can eternal lie!
To get an answer to your question, let me connect you to a helpdesk a few time zones away.
The news follows revelations last week that 207,000 BMCs exposed to the pubic internet...
The anal probing in the 21st century is done online!
I've made seriously huge speedups in some applications...
Yeah, well done. You know, we express the heuristic about how some need shall be economically solved using the MONEY metric. If there is MONEY to pay Mr BlueGreen to optimize some application, swell. If there is not enough MONEY to gainfully employ Mr BlueGreen but there is enough MONEY to buy another server instead, swell too. If the machine on which Mr BlueGreen might have optimized an application doesn't exist because someone decided that MONEY shall be spent transforming sandpeople into carbonized hungs of meat, tough luck.
Brain + experience + knowledge -> usually much, much better than just throwing new hardware at problem
Only true in the world of no economic limitations where "brain + experience + knowledge" can be had at lower prices than more hardware. Recently, this has not been the case in this dimension. As an aside, people tend to bitch and moan once the "brain + experience + knowledge" counterpart expressed in MONEY comes down. I wonder why. Yeah, we liked it in those caves.
the lost opportunity to do something better with all that computation
As I said, it's MONEY. Buy the computation, do something better with it. Maybe run SETI@Home, who knows,
I work from home and make my living selling tools for Microsoft's cloud platform.
Not sure whether serious or bot-pumped commercial.
I don't think I will even need the type cover. I can just pull the Surface Pro 3 out from the docking station, leave the office, and if I get an order I can quickly deal with it through the touch screen alone. On return to the office, slot it back in the docking station and continue working.
I can actually see the movie. Bright saturated colors. A sunny day. Smiling young people everyhwere. I can hear the background music. A bit jazzy, but not too intrusive. Good job.
The federal court overseeing the country's spy agencies renewed an order Friday allowing the National Security Agency to collect phone records of people in the United States [which of course is exactly the thing the NSA does not have a mandate to do in the first place]
The Foreign Intelligence Surveillance Court's renewal of the contested program, authorized under Section 215 of the Patriot Act, comes as lawmakers continue to debate reform legislation.
"Given that legislation has not yet been enacted, and given the importance of maintaining the capabilities of the Section 215 telephony metadata program, the government has sought a 90-day reauthorization of the existing program," the Justice Department and Office of the Director of National Intelligence (ODNI) said in a joint statement.
The House last month passed the USA Freedom Act to end the phone records program, but that bill is still working its way through the Senate. Multiple reform advocates have worried that it does not go far enough.
The bill would end the NSA program and require government agents to get a court order before searching private phone companies' storehouses of phone records, a move endorsed by President Obama earlier this year.
100% of housewives agree that "Endorsed by President Obama"™ is even better than being "Endorsed by Spokesman Buttblugg"
but it's full of libertarian, fedora-wearing douchebags
Not wanting to lose your Keynesianistic state-sponsored pension scheme and maternity leave, dear?
(Protip: It's too late)
but traditional 'male' spaces are still closed to women
Retarded bullshit is retarded, aka. "Help, help, I'm being repressed!"
Thank you, Lord Babbage!
become vets, nurses, social workers or teachers - professions which come with superb pensions
A final annoucement just before the crash in taxpayer-financed healthcare and education occurred....
This artist has flunked art school and now goes into "scientific illustrations" unencumbered by any idea of what he's drawing about.
A "black hole" is not a Hollywood-style sinkhole in space. It "looks" like this:
> Fresh Dabbs article
> 15 comments about one second after
Are people have Nagios hardwired to look for Dabbs on Friday mornings?
Why are these guys having so much fun?
1.4 Instagrams
This is a price worth paying.
Meanwhile, prepare for and additional 30-40 instagrams to be dropped on ISIS while Ahmed Chalabi (yes, the guy with the fake WMD) is again in the run for Iraqi top dog.
Hollywood logic.
Do not "go in the directon of Sagittarius" looking for random crap floating out there.
You point a fracking telescope in that direction. Then do VERY long exposures. The problem is that the galactic center is in the background.


text:
Most Recent Articles In Executive Changes
Latest Executive Changes Articles
- Willy Bogner Names Successor
- L'Oréal Creates General Management Structure for France
- Lyst Makes New Hires, Jose Ojeda Named COO
More Articles By
PARIS — Japanese retail giant Fast Retailing Co. Ltd. has tapped Nathalie Schneider to become international retail director of its brand Comptoir des Cotonniers.
Schneider's arrival was effective in January, the group said on Monday.
Joining the company from Benetton, where she held the position of sales and retail director for Northern Europe, Schneider previously spent 14 years at Levi Strauss & Co., where she served in several managerial positions, most notably as managing director for France, its overseas territories and departments and French-speaking African countries.
Fast Retailing Co. Ltd. is the parent company of Uniqlo, Link Theory, Princesse Tam Tam and Comptoir des Cotonniers.


text:
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A Romance of the Westralian Goldfields, [en] 1897
The Vampire Maid, [en] 1900
See it as donating a moment of your social media time, every little thing helps us improve and stay online.
Cara Devon has always suffered curiosity and im... Read more
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text:
Tuesday Trivia Night With Todd & Andy At Hoops Sports Bar & Grill
Have a bunch of useless facts occupying your brain?
Have a bunch of useless facts occupying your brain?
One of the biggest deterrents to playing the lottery is the realization that one is far more likely to be struck by lightning than hitting the lotto.
Well, check this out ...
So, just what exactly are the odds of filling out a PERFECT bracket for the NCAA Men's Basketball tournament?
Mathematics professor Jeff Bergen at DePaul University knows!
Clearly representing the Seattle Seahawks 12th Man as evidenced by his screen name "Hawk'sNest," Jeff Schlect of Yakima is our first ever winner in the $10,000 Football Pick 'Em Challenge!
It's your chance to win cash! Two chances at a $1,000 each weekday just by listening to 94.5 KATS. AND you can win $10,000 this month, right here on our katsfm.com. Man, that's a lot of cabbage.
Earlier tonight was the culmination of 15 weeks of football tailgate parties we held every week at Jackson's Sports Bar & Clubhouse Lounge.
Following the game between New York and Tennessee, we put every entry listeners and party-goers had amassed over the course of the season for our final Grand Prize drawing - $2,000 cash - courtesy of Akland Pump and Irrigation and Premier Power Sports.
The winner had to be present to win or we would draw another name.
Here's how it went down:
With tonight's Powerball jackpot already exceeding $500 million, it's difficult for even the most cynical person to abstain from buying a ticket. With that ticket comes the mental gymnastics that ensue when one poses the question to self: "What's the first thing I would do if I won?"
That was the question I posed on our Facebook page this morning on "The Big Show." Here are the often amusing answers:
Congrats to Kris Garland who won $10,000 in the Big-Ass Ca$h Bailout earlier today! You should be our next big winner.
94.5 KATS is giving you a chance to win $10,000!
On December 1st you could be the lucky winner of TEN GRAND. Say goodbye to those holiday bills by entering to win some serious cash, and maybe get 10 Grand in YOUR hand...


text:
|Numéro de publication
|Type de publication
|Numéro de demande
|Date de publication
|1 mars 2007
|Date de dépôt
|29 aoűt 2006
|Date de priorité
|29 aoűt 2005
|Autre référence de publication
|Numéro de publication
|Mizuo Nakayama, Takehiko Matsumura, Hidero Akiyama, Akihiko Matsumura
|Cessionnaire d'origine
|Transcutaneous Technologies Inc.
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Référencé par (8), Classifications (12), Événements juridiques (5)
|Liens externes: USPTO, Cession USPTO, Espacenet
This application claims priority from Japanese Application No. 2005-247994, filed Aug. 29, 2005, now pending, which application is incorporated herein by reference in its entirety. This application also claims the benefit under 35 U.S.C. § 119(E) of U.S. Provisional Patent Application No. 60/720,822, filed Sep. 26, 2005, which application is incorporated herein by reference in its entirety.
1. Field
The present disclosure generally relates to the field of transdermal delivery of an ionic active agent via iontophoresis, and in particular, to an electrolyte solution composition that may be used as a conductive medium in an iontophoresis device.
2. Description of the Related Art
Iontophoresis (also known as iontophorese, ion introduction method, ion permeation therapy; see JP 63-35266 A) is a method of delivering an ionic active agent placed on biological interface, mucosa, or other biological interface into a subject by means of an electromotive force sufficient to drive the ionic active agent into and/or through the biological interface.
For example, positively charged ions may be delivered into the biological interface from an anode (positive electrode) of an iontophoresis device, while negatively charged ions may be delivered into the biological interface from a cathode (negative electrode) thereof.
Device structures and constituent materials for iontophoresis have already been proposed (for examples, refer to JP 63-35266 A, JP 04-297277 A, JP 2000-229128 A, JP 2000-229129 A, JP 2000-237327 A, JP 2000-237328 A, and/or WO 03/037425 A1).
Physiological saline (an aqueous solution of NaCl) has conventionally often been used as a conductive medium in an electrode assembly of an iontophoresis device. However, an electrochemical reaction may occur on an anode (positive electrode) side and a cathode (negative electrode) side when using physiological saline, leading to the electrolytic reaction of an electrolyte solution. As a result, gas bubbles may be generated at both electrodes. For example, hydrogen gas may be generated at the cathode, while chlorine gas and oxygen gas may be generated at the anode. Gas bubbles may significantly increase the electrical resistance of electrode surfaces, inhibiting the flow of electric current.
One method that may be used to reduce the likelihood of gas generation is to add a compound to the electrolyte that is likely to be oxidized or reduced at an electric potential lower than that required for an electrolytic reaction of water (oxidation at the anode or reduction the cathode). Refer to JP 2000-229128 A for an example of such. Ferrous sulfate, ferric sulfate, or an organic acid having an oxidation-reduction potential lower than the electrolytic potential of water may be used. Specifically, a conductive medium on a cathode side of an iontophoresis electrode assembly may comprise physiological saline containing a compound that is likely to be reduced (ferric sulfate), while a conductive medium on an anode side of the iontophoresis electrode assembly may comprise physiological saline containing a compound that is likely to be oxidized (ferrous sulfate). When ferric sulfate is used, ferric ions may be reduced to ferrous ions at the cathode. When ferrous sulfate is used, ferrous ions may be oxidized to ferric ions at an anode. Problems relating to the generation of gas due to the electrolytic reaction of water may thus be mitigated.
In such a device, however, appropriate compositions may need to be prepared for each electrode (cathode and anode), thus complicating iontophoresis device production. Costs may increase, and a suitable electrolyte solution must be identified for each electrode. This may be disadvantageous to handling.
In one aspect, the present disclosure is directed to a general purpose electrolyte solution composition capable of being used as a conductive medium in an anode and in a cathode of an iontophoretic device. The electrolyte solution composition may include a compound having an oxidation-reduction potential lower than that of water. The compound may contain, in combination, a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized relative to water.
In one aspect, the present disclosure is directed to a general purpose electrolyte solution composition that may be prepared by adding a component that oxidizes at an electrical potential lower than that the oxidation potential of water on an anode side, and a component that reduces at an electrical potential higher than the reduction potential of water on a cathode side in combination.
In one aspect, the present disclosure is directed to an electrolyte solution composition which may:
In one aspect, the present disclosure is directed to a general purpose electrolyte solution composition that may include an ascorbate and a fumarate.
In one aspect, the present disclosure is directed to a general purpose electrolyte solution composition that further contains polyacrylic acid and/or lactic acid to impart a buffering action.
In one aspect, the present disclosure is directed to a gel matrix that includes a gel containing the above electrolyte solution composition.
In one aspect, the present disclosure is directed to an electrode assembly for an iontophoresis device that includes any of the electrolyte solutions described above.
In the drawings, identical reference numbers identify similar elements or acts. The sizes and relative positions of elements in the drawings are not necessarily drawn to scale. For example, the shapes of various elements and angles are not drawn to scale, and some of these elements are arbitrarily enlarged and positioned to improve drawing legibility. Further, the particular shapes of the elements as drawn, are not intended to convey any information regarding the actual shape of the particular elements, and have been solely selected for ease of recognition in the drawings.
In the following description, certain specific details are set forth in order to provide a thorough understanding of various disclosed embodiments. However, one skilled in the relevant art will recognize that embodiments may be practiced without one or more of these specific details, or with other methods, components, materials, etc. In other instances, well-known structures associated with iontophoresis devices, controllers, voltage or current sources and/or membranes have not been shown or described in detail to avoid unnecessarily obscuring descriptions of the embodiments.
Unless the context requires otherwise, throughout the specification and claims which follow, the word "comprise" and variations thereof, such as, "comprises" and "comprising" are to be construed in an open, inclusive sense, that is as "including, but not limited to."
Reference throughout this specification to "one embodiment," or "an embodiment," or "another embodiment" means that a particular referent feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases "in one embodiment," or "in an embodiment," or "another embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Further more, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
It should be noted that, as used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. Thus, for example, reference to a system for evaluating an iontophoretic active agent delivery device including "a controller" includes a single controller, or two or more controllers. It should also be noted that the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.
As used herein the term "membrane" means a boundary, a layer, barrier, or material, which may, or may not be permeable. The term "membrane" may further refer to an interface. Unless specified otherwise, membranes may take the form a solid, liquid, or gel, and may or may not have a distinct lattice, non cross-linked structure, or cross-linked structure.
As used herein the term "ion selective membrane" means a membrane that is substantially selective to ions, passing certain ions while blocking passage of other ions. An ion selective membrane for example, may take the form of a charge selective membrane, or may take the form of a semi-permeable membrane.
As used herein the term "charge selective membrane" means a membrane that substantially passes and/or substantially blocks ions based primarily on the polarity or charge carried by the ion. Charge selective membranes are typically referred to as ion exchange membranes, and these terms are used interchangeably herein and in the claims. Charge selective or ion exchange membranes may take the form of a cation exchange membrane, an anion exchange membrane, and/or a bipolar membrane. A cation exchange membrane substantially permits the passage of cations and substantially blocks anions. Examples of commercially available cation exchange membranes include those available under the designators NEOSEPTA, CM-1, CM-2, CMX, CMS, and CMB from Tokuyama Co., Ltd. Conversely, an anion exchange membrane substantially permits the passage of anions and substantially blocks cations. Examples of commercially available anion exchange membranes include those available under the designators NEOSEPTA, AM-1, AM-3, AMX, AHA, ACH and ACS also from Tokuyama Co., Ltd.
As used herein, the term bipolar membrane means a membrane that is selective to two different charges or polarities. Unless specified otherwise, a bipolar membrane may take the form of a unitary membrane structure, a multiple membrane structure, or a laminate. The unitary membrane structure may include a first portion including cation ion exchange materials or groups and a second portion opposed to the first portion, including anion ion exchange materials or groups. The multiple membrane structure (e.g., two film structure) may include a cation exchange membrane laminated or otherwise electrically coupled to an anion exchange membrane. The cation and anion exchange membranes initially start as distinct structures, and may or may not retain their distinctiveness in the structure of the resulting bipolar membrane.
As used herein, the term "semi-permeable membrane" means a membrane that is substantially selective based on a size or molecular weight of the ion. Thus, a semi-permeable membrane substantially passes ions of a first molecular weight or size, while substantially blocking passage of ions of a second molecular weight or size, greater than the first molecular weight or size. In some embodiments, a semi-permeable membrane may permit the passage of some molecules a first rate, and some other molecules a second rate different than the first. In yet further embodiments, the "semi-permeable membrane" may take the form of a selectively permeable membrane allowing only certain selective molecules to pass through it.
As used herein, the term "porous membrane" means a membrane that is not substantially selective with respect to ions at issue. For example, a porous membrane is one that is not substantially selective based on polarity, and not substantially selective based on the molecular weight or size of a subject element or compound.
As used herein and in the claims, the term "gel matrix" means a type of reservoir, which takes the form of a three dimensional network, a colloidal suspension of a liquid in a solid, a semi-solid, a cross-linked gel, a non cross-linked gel, a jelly-like state, and the like. In some embodiments, the gel matrix may result from a three dimensional network of entangled macromolecules (e.g., cylindrical micelles). In some embodiment a gel matrix may include hydrogels, organogels, and the like. Hydrogels refer to three-dimensional network of, for example, cross-linked hydrophilic polymers in the form of a gel and substantially composed of water. Hydrogels may have a net positive or negative charge, or may be neutral.
A used herein, the term "reservoir" means any form of mechanism to retain an element, compound, pharmaceutical composition, active agent, and the like, in a liquid state, solid state, gaseous state, mixed state and/or transitional state. For example, unless specified otherwise, a reservoir may include one or more cavities formed by a structure, and may include one or more ion exchange membranes, semi-permeable membranes, porous membranes and/or gels if such are capable of at least temporarily retaining an element or compound. Typically, a reservoir serves to retain a biologically active agent prior to the discharge of such agent by electromotive force and/or current into the biological interface. A reservoir may also retain an electrolyte solution.
A used herein, the term "active agent" refers to a compound, molecule, or treatment that elicits a biological response from any host, animal, vertebrate, or invertebrate, including for example fish, mammals, amphibians, reptiles, birds, and humans. Examples of active agents include therapeutic agents, pharmaceutical agents, pharmaceuticals (e.g., an active agent, a therapeutic compound, pharmaceutical salts, and the like) non-pharmaceuticals (e.g., cosmetic substance, and the like), a vaccine, an immunological agent, a local or general anesthetic or painkiller, an antigen or a protein or peptide such as insulin, a chemotherapy agent, an anti-tumor agent. In some embodiments, the term "active agent" further refers to the active agent, as well as its pharmacologically active salts, pharmaceutically acceptable salts, prodrugs, metabolites, analogs, and the like. In some further embodiment, the active agent includes at least one ionic, cationic, ionizable and/or neutral therapeutic active agent and/or pharmaceutical acceptable salts thereof. In yet other embodiments, the active agent may include one or more "cationic active agents" that are positively charged, and/or are capable of forming positive charges in aqueous media. For example, many biologically active agents have functional groups that are readily convertible to a positive ion or can dissociate into a positively charged ion and a counter ion in an aqueous medium. While other active agents may be polarized or polarizable, that is exhibiting a polarity at one portion relative to another portion. For instance, an active agent having an amino group can typically take the form an ammonium salt in solid state and dissociates into a free ammonium ion (NH4 +) in an aqueous medium of appropriate pH. The term "active agent" may also refer to neutral agents, molecules, or compounds capable of being delivered via electro-osmotic flow. The neutral agents are typically carried by the flow of, for example, a solvent during electrophoresis. Selection of the suitable active agents is therefore within the knowledge of one skilled in the art.
Non-limiting examples of such active agents include lidocaine, articaine, and others of the -caine class; morphine, hydromorphone, fentanyl, oxycodone, hydrocodone, buprenorphine, methadone, and similar opioid agonists; sumatriptan succinate, zolmitriptan, naratriptan HCl, rizatriptan benzoate, almotriptan malate, frovatriptan succinate and other 5-hydroxytryptaminel receptor subtype agonists; resiquimod, imiquidmod, and similar TLR 7 and 8 agonists and antagonists; domperidone, granisetron hydrochloride, ondansetron and such anti-emetic active agents; zolpidem tartrate and similar sleep inducing agents; L-dopa and other anti-Parkinson's medications; aripiprazole, olanzapine, quetiapine, risperidone, clozapine and ziprasidone as well as other neuroleptica; diabetes active agents such as exenatide; as well as peptides and proteins for treatment of obesity and other maladies.
As used herein and in the claims, the term "subject" generally refers to any host, animal, vertebrate, or invertebrate, and includes fish, mammals, amphibians, reptiles, birds, and particularly humans.
The headings provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
Iontophoresis Device
The counter electrode assembly 4 comprises: an electrode 16 having a polarity opposite to that of the electrode 11 of the active electrode assembly 2, the electrode 16 being electrically coupled via a lead wire 6 to the electric power source device 3; an electrolyte solution reservoir 17 that holds an electrolyte solution, the electrolyte solution reservoir 17 electrically coupled to the electrode 16; and an ion exchange membrane 18 that selectively passes ions having a polarity opposite to that of the charged ion of the ionic active agent, the ion exchange membrane 18 electrically coupled to the electrolyte solution reservoir 17.
Upon energization, the ionic active agent migrates away from the electrode 11 by virtue of an electric field, and is efficiently released through the ion exchange membrane 15. The ionic active agent may efficiently be administered to a biological interface 7 because substantially no competitive ionic species are present in the active agent solution reservoir 14. Examples of competitive ionic species include un-reacted cross linking agents, cross linking initiators, and monomers.
The electrolyte solution described here may be commonly used in both the active electrode assembly and in the counter electrode assembly described above. The composition of the electrolyte solution composition is described in detail below.
Conditions under which the active agent solution reservoir 14 is impregnated with an ionic active agent and an electrolyte solution may be suitably determined in accordance with, for example, impregnation amounts and impregnation speeds of the ionic active agent and the electrolyte solution. Example conditions for impregnation include a temperature of 40° C. and a time period of 30 minutes.
The active agent solution reservoir 14 may comprise a thin film. The active agent solution reservoir 14 may be used as, for example, an ion conductive porous sheet for forming a gel-like solid electrolyte in accordance with the description of JP 11-273452 A.
A cation exchange membrane and an anion exchange membrane may be advantageously used together as the ion exchange membrane 13 and the ion exchange membrane 15. The electrolyte solution reservoir 12 may comprise a thin film capable of holding an electrolyte solution.
In addition, an inactive electrode made of a conductive material such as carbon or platinum may be used as the electrode in one or both of the electrode assemblies.
WO 03/037425 A1, incorporated herein by reference in its entirety, describes components that may be used in the iontophoresis device 1.
Electrolyte Solution Composition
An electrolyte solution composition may be used as a conductive medium of an iontophoresis device in both an anode and a cathode. The electrolyte solution may comprise a compound having an oxidation-reduction potential lower than that of water, the compound comprising, in combination, a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.
Specific examples of such components include a combination of an ascorbate and a fumarate. Those compounds effect substantially no chemical reaction in aqueous solution states in a typical condition (when not being used, during storage) when used in combination.
Examples of ascorbates include trisodium ascorbyl2-phosphate, magnesium ascorbate, and disodium ascorbyl2-phosphate.
Examples of fumarates that may be used include sodium fumarate and potassium fumarate.
Ascorbates may effectively inhibit the electrolysis of water at an anode because it is oxidized at an electric potential lower than the oxidation potential of water. In addition, electrolysis of water may not occur at a cathode because the above-described fumarate is reduced at an electric potential higher than the reduction potential of water. The generation of gas resulting from the electrolysis of water may thus be inhibited.
A buffering agent, such as polyacrylic acid or lactic acid, may also be used in the electrolyte solution in order to stabilize pH.
The general purpose electrolyte solution composition may be the form of a gel matrix containing the composition.
An iontophoresis device having the configuration shown in
Components Molar concentration Trisodium ascorbyl2-phosphate 0.42 M Sodium fumarate 0.019 M Polyacrylic acid (molecular 0.139 M weight: 25,000) Water Balance
Energization Test
An electrolyte solution reservoir holding the general purpose electrolyte solution shown above was mounted on each of the active electrode assembly and the counter electrode assembly, and then an active agent release test was performed under the following conditions. The generation of gas due to the electrolysis of water was not observed.
Drug solution reservoir used: Lidocaine (2%)
Electrode: Carbon
Energizing conditions: 0.94 mA/cm2, 90 minutes
The above description of illustrated embodiments, including what is described in the Abstract, is not intended to be exhaustive or to limit the embodiments to the precise forms disclosed. Although specific embodiments and examples are described herein for illustrative purposes, various equivalent modifications can be made without departing from the spirit and scope of the disclosure, as will be recognized by those skilled in the relevant art. The teachings provided herein of the various embodiments can be applied to other problem-solving systems devices, and methods, not necessarily the exemplary problem-solving systems devices, and methods generally described above.
The various embodiments described above can be combined to provide further embodiments. All of the U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification and/or listed in the Application Data Sheet are incorporated herein by reference, in their entirety.
Aspects of the embodiments can be modified, if necessary, to employ systems, circuits, and concepts of the various patents, applications, and publications to provide yet further embodiments.
All of the above U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification and/or listed in the Application Data Sheet, are incorporated herein by reference, in their entirety.
These and other changes can be made to the embodiments in light of the above-detailed description. In general, in the following claims, the terms used should not be construed to limit the invention to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which such claims are entitled. Accordingly, the scope of the invention shall only be construed and defined by the scope of the appended claims.
|Brevet citant
|Date de dépôt
|Date de publication
|29 déc. 2006
|7 déc. 2010
|Tti Ellebeau, Inc.
|Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
|14 sept. 2006
|15 févr. 2011
|Tti Ellebeau, Inc.
|Iontophoresis device
|29 nov. 2007
|22 nov. 2011
|Tti Ellebeau, Inc.
|Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
|7 aoűt 2006
|23 oct. 2012
|Tti Ellebeau, Inc.
|Iontophoresis device
|8 aoűt 2006
|26 févr. 2013
|Tti Ellebeau, Inc.
|Iontophoresis device
|30 juin 2005
|4 mai 2006
|Transcutaneous Technologies Inc.
|Electrode and iontophoresis device
|16 nov. 2005
|22 juin 2006
|Akihiko Matsumura
|Iontophoretic device and method for administering immune response-enhancing agents and compositions
|2 aoűt 2005
|19 oct. 2006
|Transcutaneous Technologies Inc.
|External preparation, method of applying external preparation, iontophoresis device, and percutaneous patch
|Classification aux États-Unis
|424/449, 604/20
|Classification internationale
|Classification coopérative
|Classification européenne
|6 nov. 2006
Owner name: TRANSCUTANEOUS TECHNOLOGIES INC., JAPAN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:NAKAYAMA, MIZUO;MATSUMURA, TAKEHIKO;AKIYAMA, HIDERO;AND OTHERS;REEL/FRAME:018486/0954;SIGNING DATES FROM 20061023 TO 20061031
|5 déc. 2007
Owner name: ELLEBEAU, INC.,JAPAN
Free format text: MERGER;ASSIGNOR:TRANSCUTANEOUS TECHNOLOGIES, INC.;REEL/FRAME:020200/0803
Effective date: 20070901
|7 déc. 2007
Owner name: TTI ELLEBEAU, INC.,JAPAN
Free format text: CHANGE OF NAME;ASSIGNOR:ELLEBEAU, INC.;REEL/FRAME:020214/0336
Effective date: 20070901
|12 déc. 2007
Owner name: TRANSCU LTD.,SINGAPORE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TTI ELLEBEAU, INC.;REEL/FRAME:020236/0175
Effective date: 20071112
|10 mars 2008
Owner name: TTI ELLEBEAU, INC.,JAPAN
Free format text: RESCISSION OF PRIOR ASSIGNMENT;ASSIGNOR:TRANSCU LTD.;REEL/FRAME:020626/0021
Effective date: 20080215


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So my 3yr old fell asleep around 7pm. We let him sleep since his bed time is between 8-9 anyways. Well he WOKE UP around 10 and he is STILL up!!!! It is almost 3am our time!!!! I am SOOOO tired and I keep hoping that he will fall asleep! I even keep telling him to lay back down and go to sleep b/c its really late. He lays there for a bit then gets up to talk about stuff. I don't want to go to sleep and hope that the TV will "Watch" him b/c well one, it's not right he's still a bit too young and 2. This Boy gives me a run for my money everyday. I can see it now. Me falling asleep on the couch and wake up to him cooking a pizza and smoking a cigg. Ok so that is BIG lie, but I hope you get the drift.I hope you all are nicely tucked away in your beds sleeping... I am jealous!!!!
Posted 10/07/2012
Comments (1)
Posted 10/07/2012
my daughter has done this a couple times... u dont want to wake them bc u hope they wil sleep thru the night and if u do wake them usually they are cranky butts... i usually feed her something nice and filling and warm like oatmeal(without sugar) turn off all the lights and put on cartoons that she will just kind of chill out and watch. and if she is still hyper then i will just lay with her until we both fall asleep. hope he goes to bed soon. and i wish i could go to bed soon too...its 3 am my time and i am not the least bit tired and i will paying for this tomorrow!
Your growing child
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Suffolk County
Westbury, NY
B.A., Communication Arts, C.W. Post
The two beautiful campuses in great locations (Manhattan and Old Westbury).
Be sure to visit the campuses. It is the only way to really get the true vibe of a campus and to see where you feel the most at home.
Disney World
taking care of my family.


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Videos tagged "treatment of Parkinson's"
Bettering Life with Parkinson's02:05
Jerry Bramlett is among the one million people in the U.S. who is living life with Parkinson's disease. "I started progressing with Parkinson's when I was in my early 40s. I noticed a tremor and I was having trouble with my balance. And people kept saying that I was mad all the time cause they said I had a masked face," says Bramlett. Bramlett has come along way since then, and so has the way we treat people with Parkinson's. "What was thought at one point, medication was the only thing that could help with Parkinson's. But scientific research has proven that exercise started very, very, early- and the diagnosis is the key," says Nathalie Grondin, physical therapist on Lee Memorial Health System's medical staff. The diagnosis used to be an end-point. Now it's a beginning. "So lean into my hand, lean, lean, lean and this is what we want to see. A person with Parkinson's would do all these small steps ineffectively and this is why they tend to go backwards," says Grondin. Professionals with Lee Memorial Health System are trained to work with Parkinson's patients and assess their skills. "There's 41 different areas we evaluate on a scale 0 thru 4 and we would grade people on these areas it's called Unified Parkinson's Disease Rating Scale," says Grondin. The screening creates a snapshot in time. How a patient is doing at a particular moment and what therapies could make their lives easier. "Regular exercise, activity targeted towards specific problems can actually slow the progression of Parkinson's," says Grondin. This neurodegenerative disease is marked by rigidity. Therapy falls into three areas: physical, occupational and speech. Bramlett used them all to his advantage. "The more you work at it, the more it improves," says Bramlett. Bramlett was such a good pupil; he is now helping others as a Parkinson's exercise class leader. View More Health Matters video segments at leememorial.org/healthmatters/ Lee Memorial Health System in Fort Myers, FL is the largest network of medical care facilities in Southwest Florida and is highly respected for its expertise, innovation and quality of care. For nearly a century, we've been providing our community with everything from primary care treatment to highly specialized care services and robotic assisted surgeries. Visit leememorial.org+ More details
What are Tags?
Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."


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Category:San Marino-related lists
From Wikipedia, the free encyclopedia
This category has the following 2 subcategories, out of 2 total.
- ► Lists of biota of San Marino (1 P)
- ► San Marino politics-related lists (empty)
Pages in category "San Marino-related lists"
The following 24 pages are in this category, out of 24 total. This list may not reflect recent changes (learn more).


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Hotels, Restaurants and Leisure
Company Overview of Interstate Hotels & Resorts Inc.
Company Overview
4501 North Fairfax Drive
Suite 500
Arlington, VA 22203
United States
Founded in 1998
19,000 Employees
Key Executives for Interstate Hotels & Resorts Inc.
Interstate Hotels & Resorts Inc. Key Developments
Interstate Hotels & Resorts recently announced the appointment of Richard Tannenbaum as senior vice president of sales and marketing of the company's Rim Hospitality Division. Tannenbaum is responsible for leading the West Coast sales division across a portfolio of 70 hotels, and is a member of Interstate's global Sales and Marketing Division lead by George Brennan, executive vice president of sales and marketing. Bringing nearly a decade of sales, revenue experience and insight to his new role as SVP of sales and marketing, Tannenbaum joins Interstate after eight years with Hilton Worldwide. Prior to joining the Company, Tannenbaum served as director of sales and marketing at Homewood Suites by Hilton, followed by manager, and then director of regional sales and revenue management support for Hilton Worldwide.
Interstate Hotels & Resorts recently announced the appointment of Stephen K. Miller as senior vice president of development and acquisitions effective June 1, 2015, reporting directly to Interstate's chief investment officer, Leslie Ng. Miller was previously SVP of Development at Wyndham Hotels & Resorts, responsible for the growth of the Tryp and Dream brand portfolios through the signing of management, investment and franchise agreements throughout North America and the Caribbean.
Interstate Hotels & Resorts has signed 18 management agreements with an affiliate of Cerberus Capital Management for its hotel portfolio in the UK. The new deal increases the Interstate's UK division's hotel-portfolio to 59 in the country. The 18-hotel portfolio includes 2,443 guestrooms, covering the Holiday Inn and Crowne Plaza branded properties. Under the deal, Interstate will manage a 216-room Holiday Inn Gatwick London Airport, 142-room Holiday Inn Farnborough, 202-room Holiday Inn Reading South, 188-room Holiday Inn Leicester, 144-room Holiday Inn Hemel Hempstead, and a 139-room Holiday Inn Aylesbury, as well as a 130-room Holiday Inn Southampton. The deal also includes a 112-room Holiday Inn High Wycombe, 101-room Holiday Inn Edinburgh City West, 135-room Crowne Plaza Leeds, 158-room Holiday Inn Coventry, 107-room Holiday Inn London Bexley, 125-room Holiday Inn Gloucester, Cheltenham, and a 105-room Holiday Inn Maidstone, Sevenoaks. In addition, the portfolio comprises an 86-room Holiday Inn Basingstoke, 24-room Holiday Inn Fareham, 100-room Holiday Inn Hull Marina, and a 129-room Holiday Inn Southampton.
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To contact Interstate Hotels & Resorts Inc., please visit www.ihrco.com. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at email@example.com.


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789d ago - With its charming time travel concept, accessible fighting system, detailed characterization, and... | Android
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1009d ago - Captain Steve0 writes, "An RPG released originally on the SNES back in the nine-five, Chrono Trig... | Retro
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Now - October is upon us and, as award season starts to gear into life, a whole slew of top movie releases hit US cinemas; amongst which will see a retur... | Promoted post
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1302d ago - Knowyourmobile: Nintendo's SNES is rightly regarded as one of the finest video game consoles ever... | iPhone
TheAppera: Chrono Trigger Review
1363d ago - TheAppera: At first, I was super excited to start playing one of my favorite RPG's of all time. A... | iPhone
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1366d ago - Does the conversion to iOS make this legendary RPG another must buy? | iPhone
Pocket Gamer - Chrono Trigger Review
1391d ago - Pocket Gamer - Game criticism law stipulates that every single review of Chrono Trigger has to st... | iPhone
Anime Courtyard | Chrono Trigger Review (PSN)
1392d ago - Mario writes "Long ago, back in the 90′s when Seth Green had a girly haircut and we all used "rad... | PS3
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1410d ago - Armyman_22 contributor to Console ControllUs writes: This game was re-released on PSN and is ver... | PS3
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1419d ago - Adam writes: "In the early days of console gaming, Japanese RPG's set the bar for the entire genr... | PS3
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Book your room at Wingate by Wyndham Dayton - Fairborn
Please enter your travel dates.
Get an overview of this hotelFamily-friendly hotel with free breakfast and indoor pool
This family-friendly Fairborn hotel is located in a shopping district, within 3 mi (5 km) of Wright State University, Mall at Fairfield Commons and Dayton Aviation Heritage National Historical Park. Beavercreek Golf Course is 2.8 mi (4.5 km) away.
Hotel Features
This smoke-free hotel features an indoor pool, a fitness center, and a spa tub. Free continental breakfast, free WiFi in public areas, and free self parking are also provided. Other amenities include a 24-hour business center, conference rooms, and a 24-hour front desk.
Room Amenities
All 90 rooms provide free WiFi and free wired Internet, flat-screen TVs with cable channels, and conveniences like refrigerators and microwaves. Guests will also find coffee makers, free newspapers, and free local calls.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
In addition to an indoor pool, Wingate by Wyndham Dayton - Fairborn provides a spa tub and a fitness center. High-speed wired and wireless Internet access is complimentary. A 24-hour business center is on site. A complimentary breakfast is offered each morning. Event facilities measuring 3000 square feet (279 square meters) include conference space. Complimentary self parking is available on site.
Wingate by Wyndham Dayton - Fairborn is a smoke-free property.
- 24-hour front desk
- Number of floors - 4
- Fitness facilities
- Total number of rooms - 90
- Free breakfast
- Conference space
- Free WiFi
- Free wired high-speed Internet
- Free self parking
- 24-hour business center
- Conference space size (feet) - 3000
- Conference space size (meters) - 279
- Spa tub
- Indoor pool
- Smoke-free property
Family Friendly Amenities
- Family Hotel
- Indoor pool
- Free Wi-Fi
- Refrigerator
- Microwave
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi , Free wired high-speed Internet
Available in some public areas: Free WiFi , Free wired high-speed Internet
Free self parking
Room Amenities
- Connecting/adjoining rooms available
- Free cribs/infant beds
- Free newspaper
- Air conditioning
- Phone
- Free local calls
- Microwave
- Refrigerator
- Coffee/tea maker
- Daily housekeeping
- Private bathroom
- Free toiletries
- Shower/tub combination
- Iron/ironing board
- In-room safe
- Desk
- Cable TV service
- Flat-panel TV
- Free WiFi
- Free wired high-speed Internet
- Rollaway/extra beds (free)
Where to Eat
Guests are offered a complimentary continental breakfast each morning.
Nearby Things to Do
An indoor pool and a spa tub are on site. Other recreational amenities include a fitness center.
Hotel Policies
Check-in time starts at 3 PM
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Free rollaway/extra beds!
- Free cribs (infant beds)!
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
We should mention
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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DAA names Peter Kosmala as its first managing director.
With Congress breathing down its proverbial neck, the online ad industry has stepped up leadership of its fledgling self-regulatory organization, The Digital Advertising Alliance. The group has named Peter Kosmala, formerly of the International Association of Privacy Professionals, as its first managing director.
Kosmala has big plans for the DAA. "This will become a fully staffed consortium," he told ClickZ News. "A global, very broadly distributed program."
The former VP of the International Association of Privacy Professionals, Kosmala developed a program for certifying privacy and data protection professionals, the Certified Information Privacy Professional program.
He believes his professional privacy background will serve the DAA well when it comes to establishing the organization as a credible, effective self-regulatory outfit in the eyes of U.S. legislators and the Federal Trade Commission. His experience, he said, "is enormously valuable and speaks volumes to regulators." Kosmala said FTC Chairman Jon Leibowitz was made aware of his appointment before today's announcement.
Kosmala co-managed the Network Advertising Initiative, the first behavioral ad industry privacy regime, before joining the IAPP. Though the NAI helped craft principles that led to the DAA initiative, the NAI was never a member of the DAA coalition, a group of several ad industry trade associations. However, when the DAA launched its behavioral ad choice program in 2010, all members of the NAI, including over 50 ad networks, publishers, and data firms, agreed to take part.
The DAA "is the NAI on steroids," said Kosmala.
Until now, Stu Ingis, a partner with Venable LLP and general counsel for the DAA, has served in a de facto leadership role. Now that the DAA's ad choices program has officially launched, Kosmala said the organization needs an operational leader. The alliance "needed a leader who can come in, understand the space, the historical context, and why the self regulatory approach is right," he said.
The DAA currently has just two staffers - Kosmala and coordinator Michael London. The two are based in an office on L Street in Washington, D.C., in the same building as the Direct Marketing Association. That trade group has been especially aggressive when it comes to enforcing the DAA's guidelines and requiring that its members include the DAA icon in their online ads targeted through behavioral data. The icon links to information about how the ad was delivered and allows people to click to opt-out from behavioral targeting.
Though he doesn't plan to hire new staff soon, it's on the agenda next year and beyond. "I have considerable resources I can tap into from the stakeholder organizations," said Kosmala.
He stressed his mission to ensure that the DAA becomes a worldwide self-regulatory program, rather than something that applies in the U.S. only. After expanding its rollout in this country, Kosmala expects the DAA to implement the program through organizations like the Interactive Advertising Bureau's Europe arm, or IAB UK. Eventually, he hopes for rollout in Asia and elsewhere. The IAB Europe has already begun that process.
Recognizing increased scrutiny into mobile privacy by lawmakers, he also said the DAA has started working to apply its principles to mobile environments. "There's a really smart committee that we've got together to hash out principles and approaches for applying [the principles] to mobile," he said.
The Senate Privacy subcommittee held its first hearing ever this morning, which focused on mobile data security and privacy. Meanwhile, three privacy related bills have been officially introduced in the House, along with two in the Senate. Another children's privacy bill draft has also been floated for discussion in the House.
Kate Kaye was Managing Editor at ClickZ News until October 2012. As a daily reporter and editor for the original news source, she covered beats including digital political campaigns and government regulation of the online ad industry. Kate is the author of Campaign '08: A Turning Point for Digital Media, the only book focused on the paid digital media efforts of the 2008 presidential campaigns. Kate created ClickZ's Politics & Advocacy section, and is the primary contributor to the one-of-a-kind section. She began reporting on the interactive ad industry in 1999 and has spoken at several events and in interviews for television, radio, print, and digital media outlets. You can follow Kate on Twitter at @LowbrowKate.
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Hotel Complex "Yubileiny" is located in the center of Minsk. There is a splendid view of the historical center of the city the Trinity Suburb and the Svisloch quay. Availability of transportation arteria convenience of driving in is the advantage of the hotel as compared to other hotels of the city. There is a supermarket a cinema the Palace of Sports boutiques mobile communications center etc. in immediate proximity to the hotel. The hotel has everything it takes for comfortable accommodation and rest: Wi-Fi on all floors laundry and dry cleaning services hairdressers saloon newspaper stall currency exchange office and ATM car park deposit box booking office for air and railway tickets casino bowling medical care. The rooms are elegantly furnished equipped with international telephone communication multichannel CCTV Internet access mini bars safes fans. The security of the guests is guaranteed by the hotel security service video surveillance system reliable fire security system. Reception and room service are available round the clock. The hotel offers the services of the conference hall and meeting room as well as the spacious restaurant hall bars a bowling (4 tracks) and a casino.onhotels.com
24 hour front desk
Airport shuttle (surcharge)
ATM on-site
Car rental
Cable or satellite TV
Coffee shop
Concierge service
Cribs available
Currency exchange on-site
Gift shop
Laundry service
Meeting/Banquet facilities
Pets not allowed
No smoking
Parking (surcharge)
Wheelchair accessible
Room service
Beauty salon
Designated smoking area
Smoking rooms available
Storage available
Wedding services
Free Wi-Fi
Get Rates
Get Flight + Hotel


text:
Pre Filter Review
Reviewed By E Farley E (Salt Lake City, UT) Reviewed for a 2015 Ford F-350 —9/21/2015 6:35 AM
Great Pre Filter
Reviewed By BRIAN H (HONEOYE FALLS, NY) Reviewed for a 2008 Mazda B-Series —8/30/2015 6:10 PM
This vehicle always idled rough. Put Spectre air filter in and motor smoothed right out in a couple of days. Engine has more power and better mileage. Liked it so much bought one for each of my other vehicles.


text:
This iReport is part of an assignment:
Wintry weather 2014
About this iReport
- Posted January 3, 2014 by
- frankie1984 Follow
whitney pier
whitney pier
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More iReports you should see
Major Snow Storm Hitting Sydney Nova Scotia on Friday January 3, 2014
Major Snowstorm is Hitting Sydney Nova Scotia down on Victoria Road in Whitney Pier Area and it is a lot of Heavy Snow with Blowing Snow down in Whitney Pier Area and it is getting worse outside in Sydney and Blowing Snow and White Out Conditions and Visibility is Near Zero and Reduced and take caution and it is very bad outside in Sydney Nova Scotia on Friday and the storm is getting worse and it is heavy snow with Blizzard conditions in Whitney Pier Area.
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