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How it works: This coupon is good for 15% off "Teen & Young Adult" books. This discount cannot be applied to gift cards or shipping. This coupon CAN be shared with friends and family. Enter the code TEEN when checking out and click the "Apply" button to see your discount before submitting your order. This coupon expires October 31st, at 11:59 PST.
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"A TRIUMPH . . . A model of the richness and subtleties of relationships, characters, and story construction."--Chicago Sun-TimesIn his family life, Angus Stonefield had been gentle and loving; in business, a man of probity; and in his relationship with his twin brother, Caleb, a virtual saint. Now Angus is missing, and it appears more than possible that Caleb--a creature long since abandoned to depravity--has murdered him. Hired to find the missing man, William Monk puts himself into his shoes, searching for clues to Angus's fate and his vicious brother's whereabouts. Slowly, Monk inches toward the truth--and also, unwittingly, toward the destruction of his good name and livelihood. . . ."MASTERFUL . . . DARKLY CHILLING . . . Perry eloquently delivers to her readers the flavor of Victorian England. . . . Readers will be kept entertained and guessing--right up to the final pages."--Milwaukee Journal Sentinel"JUST WHEN YOU THINK YOU HAVE IT FIGURED OUT, THINK AGAIN! No one can capture and bring to life the drama, excitement, and feel of Victorian England like Perry."--Mostly MurderA Main Selection of the Mystery Guild
Posted by L. A Parker on 1/11/2009
Anne Perry really out did herself in this one. Keeps you guessing up to the end.
Posted by Anonymous on 6/17/1998
William Monk is hired by Genevieve Stonefield to find her missing husband, Angus. He was last seen visiting his twin brother Caleb, who lives in Limehouse; the destitute part of London. Monk must find Caleb, but no - one is willing to talk. Just who is Caleb, and why is everyone so afraid of him. Monk must face some of his own private demons and realises that even the simplest things can be more complicated than he ever imagined. Another brilliant novel from Anne Perry.
Posted by Cheryl Farley on 4/28/2002
I love Anne Perry's ability to twist and wind through a story and keep you hanging until the last pages. I also love her well researched novels that offer such exsquisite detail about Victorian London, especially the class differences (particularly in this book). Unfortunately I found the conclusion of this novel truly unoriginal and disappointing. The result it ended with was a thought that had ocurred to me earlier in the novel, but I doubted it just because of the lack of inspiration it required. I am more fond of the Monk/Latterly series than the Pitts series, and "Cain..." is one of the better stories among the Perry novels, but I would definitely read it knowing in advance that the ending doesn't compare with the rest of the story. If you want a truly excellent Anne Perry book, read "The Face of a Stranger" (the first Monk/Latterly novel). A great read.
Posted by Ann E. Nichols on 4/1/2001
Today I read a used first edition that I bought, so part of my review is my memory of the first time I read it. Unlike some other mysteries I'd reread lately, I had no difficulty remembering the main points -- they made too strong an impression.
I thought I knew what was going on by page five. I was correct in one supposition, but the truth was far stranger than I'd imagined.
For a time it may seem that the typhoid epidemic in evil twin Caleb's stomping grounds is irrelevant, although interesting in itself if you care about medical history. I liked learning about Hester's version of oral rehydration therapy and blanched when I read about burning tobacco leaves for fumigation. Do not allow yourself to become impatient. It's all relevant and that will be revealed in due time.
Is Angus' wife, Genevieve, a cold-hearted accessory to his murder? Did Caleb murder Angus? Is Angus still alive? Why did the author give him the same name as one of the Pitts' cats? (You may ask, but you won't get an answer.) Since we have another Angus, will an Archie show up?
What about Lord Ravensbrook, who was guardian to the Stonefield brothers? What's his role in this tragedy? Mr. Niven was unwittingly ruined by his friend, Angus. Does he really hold no grudge?
Who is the lovely Drusilla and why is she seeking out William Monk? She's a member of Society, as he isn't. Certainly her many charms give Monk the opportunity to unfavorably compare Hester to her in his mind. Will he live to regret this or does Hester have a rival? Does Hester even care?
If you're a fan of Oliver Rathbone, don't worry. He'll have plenty to do during the trial scene. Hester isn't neglected, either. I thoroughly enjoyed her solution to one person's nasty little trap for our hero.
Contrary to what other reviewers have said, this book isn't confusing. While I admit to having been partially fooled the first time I read it, once a crucial point became clear, everything made perfect sense. I definitely recommend this novel.
Posted by Anonymous on 1/11/1997
This book holds your attention from the very start. Victorian London is re-created in exquisite detail by Perry, and the characters are described in such a way that you feel like you know them. The book contains several interesting plots and a surprise ending.
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In a world laid waste by nuclear war, Amamiku guards the seeds that hold the genetic code of the planet and can be used for its rebirth. Living underwater and protected from the radioactive atmosphere above, she impatiently waits for the earth to be ready for the seeds to germinate.But when her existence is discovered, it sparks a frantic race between the remains of humanity struggling for survival, and the disembodied brain, Glyptofane. This fanatic being, who sees mankind as a plague, has programmed his robotic army to destroy them. Directed By Toshifumi Takizawa & Hisaya Takabayashi
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The amazing three-in-one cancer operation: It rebuilds your breast, gives you a tummy tuck AND cures swollen, aching arms
A quarter of a million Britons suffer from lymphoedema — swelling in the arms or legs — often because of cancer treatment.
Trisha Meredith, 50, an NHS manager from Broad Oak, Herefordshire, was one of the first to undergo a new procedure to combat it.
'I had surgery to remove my breast and 24 lymph nodes,' said Trisha Meredith
The lump I found in my left breast in May 2009 was tender and sore — which isn't typical of cancer — but my GP referred me for tests as a precaution.
When the consultant told me it was cancer I had this horrible feeling in the pit of my stomach.
It was a big lump, 3cm, very close to my ribs, and it had spread to one of my lymph nodes — small glands that are part of the immune system.
The next week, I had surgery to remove my breast and 24 lymph nodes.
This was followed by chemotherapy and three weeks of radiotherapy.
I'd been warned about lymphoedema — a swelling you can get if the lymphatic system is damaged.
The system carries away waste fluid called lymph, and lymphoedema is the result of fluid pooling.
I was fine until halfway through radiotherapy, when my arm started to swell — first my upper arm, then downwards to my hand. It felt so big and achy.
I felt as if I was carrying a weight around.
I couldn't move my arm properly and had to start wearing bigger tops.
I used the massage techniques the breast-care nurse had shown me to help reduce swelling, and also tried a tight compression garment — like an elasticated mitten. These helped, but it was still uncomfortable.
I'd wanted to have breast reconstruction as soon as the cancer treatment was complete.
I liked the idea of an operation where they do a tummy tuck and use the tissue they've removed to recreate a breast.
I was referred to NHS surgeon Anne Dancey at the Queen Elizabeth Hospital, Birmingham.
At my first appointment, in August 2010, she told me she had trained in Belgium in a procedure called lymph node transfer.
She'd take the tummy tissue to form a new breast, and would extend the incision a tiny amount on one side to take some of the lymph nodes in my groin with it.
She'd plug these lymph nodes into my armpit. The idea is that this kick-starts the lymphatic system so the lymphoedema is reversed or at least improved.
'I liked the idea of an operation where they do a tummy tuck and use the tissue they've removed to recreate a breast,' said Trisha
It adds only ten minutes to the procedure. I agreed that I had a lot to gain and nothing to lose.
I was admitted for surgery in August 2011. My husband, Laurence, who hates everything about hospitals, saw the procedure as a huge risk and pleaded with me not to have it, but I was determined.
I think the lymph node transfer started working immediately. I woke up the morning after the six-hour operation and could easily slip my wedding ring on and off — before, I couldn't budge it.
A few days later, I went back to the breast-care nurse and she measured me from the top of my arm to the bottom of my wrist — both my arms were the same size: the swelling had gone.
In May, I started jogging, and we moved house at the same time, so I was doing a lot of lifting.
I think the two combined aggravated my arm, as I got a bit of swelling. But I used the compression garment for ten days and that sorted it out.
I'm delighted with my new breast, but it's almost made more of a difference to have my arm back to normal. It's a fabulous bonus.
Anne Dancey is a consultant plastic surgeon at Queen Elizabeth Hospital, Birmingham. She says:
We have no way of predicting who will get lymphoedema. Some people get the condition right after surgery.
Others are fine for years, then it's triggered by something — a long-haul flight, an injury or infection in the hand or just getting flu.
Up to 39 per cent of breast cancer patients suffer from lymphoedema, but it can also strike people who have had prostate or gynaecological cancer treatment.
In these cases, lymphoedema will occur in the legs, as lymph nodes in the groin are likely to have been damaged or removed.
The lymphatic system removes bacteria and waste from the tissues through a fine network of vessels. It is taken to the lymph nodes, where it is cleansed.
If the system is damaged, the fine lymphatic channels can get blocked.
The trapped fluid weakens the immune system, which puts patients at high risk of serious infection.
Patients with long-standing lymphoedema might have a limb swollen not just with fluid but also excess fat because the lymphatic fluid promotes fat production.
All this can have a dreadful impact on patients' lives. They may feel disfigured and some may have difficulty bending the limb.
Learning massage techniques can ease symptoms. Massage by specially trained physiotherapists is even better, but NHS provision is scarce.
Using compression garments can help, but having to wear a very tight gauntlet every day can be unbearable for patients and few like the way they look.
I've done 26 lymph-node transfers over the past year or so — all as an add-on in tummy tuck breast reconstruction surgery.
If lymph-node transfer proves successful in the longer term, it might be done in isolation.
The technique was developed in France 20 years ago — as soon as you put in the transferred nodes, they release proteins that encourage the lymphatic pathways to open up.
The results can range from an improvement to complete resolution.
First, I make two horizontal incisions, one just below the tummy button, one just above the bikini line, and by continuing this lower incision a few centimetres to one side we can feel the lymph nodes in the groin.
We take about five of these.
The nodes are attached to the flap of tummy tissue and will have their own blood supply, as does the tummy flap.
I open up the mastectomy scar, then go into the armpit to plumb in the lymph nodes.
Using special operating microscopes, I join the nodes and the tiny blood vessels and bury the nodes in a tiny pocket I create in the armpit. Within days, the lymph nodes will have started establishing their own lymphatic pathways, so lymph fluid starts to clear.
I then sculpt and tuck the tissue into a breast shape and stitch it all into place, and finally I stitch up the tummy.
Patients leave theatre with three drains to draw off excess fluid — one from the reconstructed breast and two in the tummy. The fluid is a mixture of blood and clear fluid.
The drain on the breast stays on for two days and the drains on the tummy for five. Patients stay in hospital for five to seven days.
Patients could be left with a bit of a depression in the skin where the tissue is taken from, and weeping from the tummy surgery could collect here.
However, this will clear up in a week or so.
Some specialists have expressed concern that if we're removing lymph nodes from the groin to plug into the armpit, we could leave patients with leg lymphoedema.
This hasn't happened to any of my patients and I think it is unlikely, as we are taking some of the superficial nodes in the groin, not deep lymph nodes that drain the leg.
We are trying to get funding for a trial comparing this technique to massage therapy combined with compression garments.
Lymph node transfer as part of a breast reconstruction costs the NHS £7,000.
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Are you Yasunori Yoshimura?Claim your profile
Publications (302)919.32 Total impact
Article: CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling[Show abstract] [Hide abstract]
ABSTRACT: Repeated and dramatic pregnancy-induced uterine enlargement and remodeling throughout reproductive life suggests the existence of uterine smooth muscle stem/progenitor cells. The aim of this study was to isolate and characterize stem/progenitor-like cells from human myometrium through identification of specific surface markers. We here identify CD49f and CD34 as markers to permit selection of the stem/progenitor cell-like population from human myometrium and show that human CD45(-) CD31(-) glycophorin A(-) and CD49f(+) CD34(+) myometrial cells exhibit stem cell-like properties. These include side population phenotypes, an undifferentiated status, high colony forming ability, multi-lineage differentiation into smooth muscle cells, osteoblasts, adipocytes and chondrocytes, and in vivo myometrial tissue reconstitution following xenotransplantation. Furthermore, CD45(-) CD31(-) glycophorin A(-) and CD49f(+) CD34(+) myometrial cells proliferate under hypoxic conditions in vitro and, compared with the untreated non-pregnant myometrium, show greater expansion in the estrogen-treated non-pregnant myometrium and further in the pregnant myometrium in mice upon xenotransplantation. These results suggest that the newly identified myometrial stem/progenitor-like cells influenced by hypoxia and sex steroids may participate in pregnancy-induced uterine enlargement and remodeling, providing novel insights into human myometrial physiology. Copyright 2015 by The Society for the Study of Reproduction.Biology of Reproduction 06/2015; 93(2). DOI:10.1095/biolreprod.114.127126 · 3.32 Impact Factor
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ABSTRACT: Key Clinical MessagePeritoneal pregnancy may cause severe abdominal bleeding without genital bleeding as early as the fifth week of gestation. Awareness that pregnancy can exist in unusual locations is imperative.03/2015; 3(6). DOI:10.1002/ccr3.266
Article: Genome-wide copy number analysis and systematic mutation screening in 58 patients with hypogonadotropic hypogonadism[Show abstract] [Hide abstract]
ABSTRACT: Objective To clarify the molecular basis of hypogonadotropic hypogonadism (HH). Design Genome-wide copy number analysis by array-based comparative genomic hybridization and systematic mutation screening of 29 known causative genes by next-generation sequencing, followed by in silico functional assessment and messenger RNA/DNA analyses of the mutants/variants. Setting Research institute. Patient(s) Fifty-eight patients with isolated HH (IHH), combined pituitary hormone deficiency (CPHD), and syndromic HH. Intervention(s) None. Main Outcome Measure(s) Frequency and character of molecular abnormalities. Result(s) Pathogenic defects were identified in 14 patients with various types of HH, although oligogenicity was not evident in this patient group. As rare abnormalities, we identified a submicroscopic deletion involving FGFR1 and an SOX3 polyalanine deletion in patients with IHH, and a WDR11 splice site mutation in a patient with CPHD. No disease-associated polymorphism was detected in the 58 patients. Conclusion(s) The present study provides further evidence that mutations and deletions in the known causative genes play a relatively minor role in the etiology of HH and that submicroscopic rearrangements encompassing FGFR1 can lead to IHH as a sole recognizable clinical feature. Furthermore, the results indicate for the first time that polyalanine deletions in SOX3 and mutations in WDR11 constitute rare genetic causes of IHH and CPHD, respectively.Fertility and Sterility 10/2014; 102(4):1130-1136. DOI:10.1016/j.fertnstert.2014.06.017 · 4.59 Impact Factor
Dataset: hypogonadotropic hypogonadism
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ABSTRACT: Fetuses with concomitant duodenal atresia (DA) and esophageal atresia (EA) might develop in utero gastric rupture as well as neonatal respiratory complication due to dilated stomach and duodenum. Our patient with the typical "double bubble" appearance was highly suspected to have DA in the second trimester. Follow-up examinations revealed a massively dilated stomach and duodenum with a dilated distal esophagus, indicating concomitant DA and EA. With advancing pregnancy, the fetal abdomen progressively increased in size by retention of fluid in the closed loop of DA and EA. To avoid gastric perforation, prenatal stomach paracentesis using an ultrasound-guided needle was performed three times until delivery. A male neonate born at 37 weeks gestation showed no respiratory complication. Perinatal clinical features and operative findings revealed combined DA and EA (gross type A). He was successfully managed with duodenoduodenostomy, followed by esophago-esophagostomy. On fetal sonography, the marked "double bubble" appearance and the cystic structure presenting peristalsis-like movement above the diaphragm were indicative of concomitant DA and EA. Fetal stomach paracentesis could contribute to the improvement of perinatal outcomes in fetuses with this pathological condition.Journal of Medical Ultrasonics 07/2014; 41(3):397-400. DOI:10.1007/s10396-014-0518-z · 0.62 Impact Factor
Article: Sexual Satisfaction of infertile couples assessed using the Golombok-Rust Inventory of Sexual Satisfaction (GRISS)[Show abstract] [Hide abstract]
ABSTRACT: Recently, infertility treatment-related psychological effects are receiving increased attention. However, whether sexual satisfaction is reduced amongst infertile couples remains to be elucidated. In this study, sexual satisfaction of Japanese infertile couples was assessed using a validated questionnaire designed to assess the male and female partner individually, and the couple as a whole for the first time. This study randomly included 170 infertile couples seen at the outpatient clinic and 170 couples that had recently achieved spontaneous pregnancy. All couples were given the Japanese version of the Golombok-Rust Inventory of Sexual Satisfaction (GRISS). In couples aged 35 years or older, the male partners showed significantly worse sexual satisfaction scores than the female partners. Sexual satisfaction also deteriorated with therapeutic interventions, with mental factors affected more than physical factors. Therapeutic interventions such as timed sexual intercourse and assisted reproductive technology were considered emotionally stressful for infertile couples, with sexual satisfaction accordingly lower in this group than in couples achieving spontaneous pregnancy. GRISS successfully evaluated lower sexual satisfaction associated with infertility, and hence is a useful tool for identifying couples whose sexual satisfaction could be enhanced by counselling or other stress-reduction modalities.Scientific Reports 06/2014; 4:5203. DOI:10.1038/srep05203 · 5.58 Impact Factor
Article: Validity for assisted hatching on pregnancy rate in assisted reproductive technology: Analysis based on results of Japan Assisted Reproductive Technology Registry System 2010[Show abstract] [Hide abstract]
ABSTRACT: Aim: The aim of this study was to assess the efficacy of assisted hatching (AH) in assisted reproductive technology (ART) treatment. Material and methods: In this retrospective observational study, the data of patients who were registered in the National ART Registry System of Japan between January and December 2010 were analyzed. The descriptive statistics and validity of AH in fresh embryo transfer (ET) and frozen-thawed ET were assessed by using multiple logistic regression analyses. Results: From a total of 105,450 single ET, 46,029 (43.7%) cycles underwent AH. A total of 9737 (21.3%) and 36,292 (60.9%) cycles underwent AH from 45,818 fresh single ET and 59,632 frozen-thawed single ET, respectively. In the fresh ET patients that underwent AH, the clinical pregnancy and live birth rate were significantly decreased in patients of all ages compared with that of the non-AH group. In the frozen-thawed ET patients, there was no significant difference in pregnancy and live birth rate between the AH group and the non-AH group. Conclusion: AH treatment was more frequently performed in frozen-thawed ET patients than in fresh ET patients, and in the blastocyst stage than in the early cleavage stage. A significantly decreased pregnancy and live birth rate was observed in the fresh ET patients who underwent AH. In the frozen-thawed ET patients who underwent AH, improvement in the clinical pregnancy and live birth rate was not observed. Further studies on the indication and application of AH in ART treatment are required.Journal of Obstetrics and Gynaecology Research 06/2014; 40(6):1653-60. DOI:10.1111/jog.12403 · 1.07 Impact Factor
Article: The incidence of monozygotic twinning in assisted reproductive technology: Analysis based on results from the 2010 Japanese ART national registry[Show abstract] [Hide abstract]
ABSTRACT: To assess the incidence of monozygotic twinning (MZT) among cases undergoing assisted reproductive technology (ART) treatment. We performed a retrospective observational study and analyzed the data of patients who were registered in the national ART registry system of Japan from January to December 2010; only the data of patients with single embryo transfer (ET) were included. Of 30,405 pregnancies, 425 resulted in MZT following fresh and frozenthawed ET. The MZT incidence among women undergoing ART was 1.4 %. Multiple logistic regression analysis indicated that cases undergoing fresh and frozen-thawed ET, blastocyst transfer had a significantly increased MZT rate (P < 0.01). Assisted hatching (AH) and frozen-thawed ET and maternal age did not significantly affect the MZT incidence. Of 8510 fresh ET pregnancies, 104 resulted in MZT. Multiple logistic regression analysis indicated that blastocyst transfer significantly increased the MZT rate in cases undergoing fresh ET. Ovarian stimulation, intracytoplasmic sperm injection, AH, and maternal age did not significantly affect the MZT incidence. Blastocyst transfer was associated with an increased MZT incidence. We have to be aware of the potential risk of MZT caused by blastocyst transfer. However, further studies are required to assess the correlation among specific AH types, embryo culture conditions, and MZT incidence.Journal of Assisted Reproduction and Genetics 04/2014; 31(7). DOI:10.1007/s10815-014-0225-0 · 1.72 Impact Factor
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ABSTRACT: We induced differentiation of human amnion-derived mesenchymal stem cells (AMCs) and menstrual blood-derived mesenchymal stem cells (MMCs) into endometrial stroma-like cells, which could be useful for cell therapy to support embryo implantation. Interestingly, the expression patterns of surface markers were similar among AMCs, MMCs, and endometrial stromal cells. In addition, whereas treatment with estrogen and progesterone was not very effective for decidualizing AMCs and MMCs, treatment with 8-Br-cAMP prompted remarkable morphological changes in these cells as well as increased expression of decidualization markers (prolactin and insulin-like growth factor binding protein-1) and attenuated expression of surface markers unique to mesenchymal stem cells. These results demonstrated that bone marrow-derived stem cells, which are considered a potential source of endometrial progenitor cells, as well as AMCs and MMCs show in vitro decidualization potential, which is characteristic of endometrial stromal cells.Scientific Reports 04/2014; 4:4599. DOI:10.1038/srep04599 · 5.58 Impact Factor
Article: Efficacy, safety, and trends in assisted reproductive technology in Japan-analysis of four-year data from the national registry system[Show abstract] [Hide abstract]
ABSTRACT: This study aimed to evaluate the efficacy, safety, and trends in assisted reproductive technology (ART) in Japan. Data pertaining to treatment cycles, pregnancy rate, live birth rate, age distribution, single embryo transfer rate, and multiple pregnancy rate were analyzed for patients registered in the national ART registry system of Japan from 2007 to 2010. The total number of treatment cycles was 161,164, 190,613, 213,800, and 242,161 in 2007, 2008, 2009, and 2010, respectively. The number of ART treatments administered to patients aged ≥40 years was 31.2 %, 32.1 %, 33.4 %, and 35.7 %, respectively, showing an increasing trend from 2007 to 2010. In each of these years, the total pregnancy rate per embryo transfer was 24.4 %, 21.9 %, 22.3 %, and 21.9 % for fresh cycles, respectively, and 32.0 %, 32.1 %, 32.5 %, and 33.7 % for frozen cycles, respectively. The single embryo transfer rate was 49.9 %, 63.6 %, 70.6 %, and 73.0 %, respectively, showing an increasing trend, while the multiple pregnancy rate was 11.5 %, 6.8 %, 5.3 %, and 4.8 %, respectively, showing a decreasing trend. From 2007 to 2010 in Japan, the number of ART treatment cycles, number of elderly patients treated, and the single embryo transfer rate increased, while the multiple pregnancy rate decreased. However, the overall pregnancy rate remained stable during the study period.Journal of Assisted Reproduction and Genetics 02/2014; 31(4). DOI:10.1007/s10815-014-0181-8 · 1.72 Impact Factor
Article: Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: Two year experience in a single institution in Japan[Show abstract] [Hide abstract]
ABSTRACT: There is a paucity of information on perinatal data regarding gestational diabetes mellitus (GDM) by the new criteria from a real experience because the number of health care associations implementing the new criteria is still limited. The aim of this study is to investigate perinatal features of the new criteria-defined GDM. We reviewed a total of 995 women with singleton pregnancy that underwent GDM screening followed by a diagnostic oral glucose tolerance test (OGTT). All women found to have GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. Of the 995 women, 141 had GDM (14.2%): 104 with one, 27 with two, and 10 with three abnormal OGTT values. Women with two or three abnormal OGTT values needed insulin treatment more frequently than those with one abnormal OGTT value (1-AV) (70.3% vs 23.1%, P < 0.0001). After adjustment for age, pregravid overweight, gestational weeks at diagnosis, a first-degree family history of diabetes was correlated with the implementation of insulin treatment in women with 1-AV (adjusted odds ratio 3.9; 95% Confidence Interval 1.7-9.2; P = 0.001). When compared perinatal outcomes between women with normal glucose tolerance and GDM, fetal growth and the occurrence of pregnancy-induced hypertension were comparable between the two groups. Our data suggest that the IADPSG-defined GDM with 1-AV show less severe glucose intolerance, but might be at risk of insulin requirement when a first-degree family history of diabetes exists.Endocrine Journal 01/2014; 61(4). DOI:10.1507/endocrj.EJ13-0496 · 2.00 Impact Factor
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ABSTRACT: Oocytes may undergo two types of aging. The first is induced by exposure to an aged ovarian microenvironment before being ovulated, known as 'reproductive or maternal aging', and the second by either a prolonged stay in the oviduct before fertilization or in vitro aging prior to insemination, known as 'postovulatory aging'. However, the molecular mechanisms underlying these aging processes remain to be elucidated. As telomere shortening in cultured somatic cells triggers replicative senescence, telomere shortening in oocytes during reproductive and postovulatory aging may predict developmental competence. This study aimed to ascertain the mechanisms underlying altered telomere biology in mouse oocytes during reproductive and postovulatory aging. We studied Tert expression patterns, telomerase activity, cytosolic reactive oxygen species (ROS) production, and telomere length in fresh oocytes from young versus reproductively-aged female mice retrieved from oviducts at 14 h post-human chorionic gonadotropin (hCG), in vivo or in vitro postovulatory-aged mouse oocytes at 23 h post-hCG. Oocytes were collected from super-ovulated C57BL/6 J mice of 6--8 weeks or 42--48 weeks of age. mRNA and protein expressions of the Tert gene were quantified using real-time quantitative reverse transcriptase polymerase chain reaction (Q-PCR) and immunochemistry. Telomerase activity was measured by a telomeric repeat amplification protocol assay, while telomere length was measured by Q-PCR and quantitative fluorescence in situ hybridization analyses. The abundance of Tert expression in oocytes significantly decreased during reproductive and postovulatory aging. Immunofluorescent staining clearly demonstrated an altered pattern and intensity of TERT protein expression in oocytes during reproductive aging. Furthermore, relative telomerase activity (RTA) in oocytes from reproductively-aged females was significantly lower than that in oocytes from young females. In contrast, RTA in postovulatory-aged oocytes was similar to that in fresh oocytes. Oocytes from reproductively-aged females and postovulatory-aged oocytes showed higher ROS levels than oocytes from young females. Relative telomere length (RTL) was remarkably shorter in oocytes from reproductively-aged females compared to oocytes from young females. However, postovulatory aging had no significant effect on RTL of oocytes. Long-term adverse effects of low telomerase activity and increased ROS exposure are likely associated with telomere shortening in oocytes from reproductively-aged female mice.Reproductive Biology and Endocrinology 11/2013; 11(1):108. DOI:10.1186/1477-7827-11-108 · 2.23 Impact Factor
Article: Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome[Show abstract] [Hide abstract]
ABSTRACT: Spontaneous ovarian hyperstimulation syndrome (sOHSS) is a rare event that may result from a FSH-producing pituitary adenoma (FSHoma), activating mutations of the FSH receptor (FSHR), and cross-reactivity of the FSHR to elevated hCG and TSH in the setting of pregnancy or hypothyroidism. The objective of this study was to investigate whether an aberrant FSHR was present in a woman with sOHSS and a non-surgically diagnosed FSHoma whose serum FSH levels and FSH bioactivity were nearly normal. Sequencing of the patient's FSHR gene revealed a heterozygous novel missense mutation c. 1536G>A resulting in an amino acid substitution M512I. We asked whether this mutant FSHR affected FSHR-mediated signaling pathways involving cAMP/protein kinase A (PKA), phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) and v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog kinase (SRC)/ p42/p44 extracellular signal-regulated protein kinases (ERK1/2). Thus, 293T cells expressing wild-type (FSHRwt), the mutant FSHR (FSHRmt), or both (FSHRwt/mt) were treated with FSH and subjected to measurements of intracellular cAMP, cAMP-induced CRE (cAMP response element)-mediated luciferase assays and immunoblot analyses of phosphorylated PI3K and ERK1/2. There were no differences in luciferase activities or phosphorylation levels of ERK1/2 among FSHRwt, FSHRmt cells and FSHwt/mt cells. However, FSHRmt cells showed a significant reduction in both cAMP production and PI3K phosphorylation levels with unchanged phosphorylation of ERK1/2 upon FSH stimulation in comparison to FSHwt cells. Also, FSH treatment did not provoke PI3K phosphorylation in FSHwt/mt cells. These results indicate that the novel missense M512I FSHR mutation identified herein did not participate in hyperactivation of FSHR-mediated signaling pathways but rather in hypoactivation of the FSH-mediated PI3K/AKT pathway. Thus, this study demonstrates a new functional property of this novel mutatnt FSHR, which, however, might not be involved in the pathogenesis of sOHSS in this FSHoma patient.PLoS ONE 09/2013; 8(9):e75478. DOI:10.1371/journal.pone.0075478 · 3.23 Impact Factor
Article: Antenatal management of recurrent fetal goitrous hyperthyroidism associated with fetal cardiac failure in a pregnant woman with persistent high levels of thyroid-stimulating hormone receptor antibody after ablative therapy[Show abstract] [Hide abstract]
ABSTRACT: High titer of maternal thyroid-stimulating hormone receptor antibody (TRAb) in patients with Graves' disease could cause fetal hyperthyroidism during pregnancy. Clinical features of fetal hyperthyroidism include tachycardia, goiter, growth restriction, advanced bone maturation, cardiomegaly, and fetal death. The recognition and treatment of fetal hyperthyroidism are believed to be important to optimize growth and intellectual development in affected fetuses. We herein report a case of fetal treatment in two successive siblings showing in utero hyperthyroid status in a woman with a history of ablative treatment for Graves' disease. The fetuses were considered in hyperthyroid status based on high levels of maternal TRAb, a goiter, and persistent tachycardia. In particular, cardiac failure was observed in the second fetus. With intrauterine treatment using potassium iodine and propylthiouracil, fetal cardiac function improved. A high level of TRAb was detected in the both neonates. To the best of our knowledge, this is the first report on the changes of fetal cardiac function in response to fetal treatment in two siblings showing in utero hyperthyroid status. This case report illustrates the impact of prenatal medication via the maternal circulation for fetal hyperthyroidism and cardiac failure.Endocrine Journal 09/2013; 60(12). DOI:10.1507/endocrj.EJ13-0248 · 2.00 Impact Factor
Article: Embryo developmental capability and pregnancy outcome are related to the mitochondrial DNA copy number and ooplasmic volume[Show abstract] [Hide abstract]
ABSTRACT: To investigate the correlation between the ooplasmic volume and the number of mitochondrial DNA (mtDNA) copies in embryos and how they may affect fecundity. Using real-time PCR, mtDNA quantification was analyzed in unfertilized oocytes and uncleaved embryos. The size of the ovum was also assessed by calculating the ooplasmic volume at the time of granulosa cell removal for IVF or ICSI. Quantification analysis of the mtDNA in blastomeres was performed by real-time PCR at the 7-8 cell stage of the cleaved embryos at 72 h after oocyte retrieval. We calculated the cytoplasmic volume of the blastomeres. Our studies showed a significantly lower mtDNA copy number in unfertilized oocytes and uncleaved embryos in women who were older than 40 years of age (p < 0.05). The larger ooplasmic volume was also associated with earlier and more rapid cleavage (p < 0.05). The ooplasmic volume was also significantly larger in the group achieving pregnancy. We found a significant positive correlation between blastomere volume and the number of mtDNA copies (r = 0.76, p < 0.01, from Pearson product-moment correlation coefficient). We have shown that blastomere volume is directly proportional to the number of mtDNA copies. Therefore, larger cytoplasmic volume, with earlier cleavage speed, implies more mtDNA copies. Evaluation of mtDNA quantification and the measurement of ooplasmic and blastomere volume may be useful for selection of high quality embryo and pregnancy outcome.Journal of Assisted Reproduction and Genetics 07/2013; 30(10). DOI:10.1007/s10815-013-0062-6 · 1.72 Impact Factor
Article: Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis[Show abstract] [Hide abstract]
ABSTRACT: Nerve growth factor (NGF) has been recently proposed as one of the key factors responsible not only for promotion of nerve fiber growth but also for the onset and maintenance of pain in a variety of diseases. The aim of this study was to investigate the role of NGF in the pelvic pain associated with endometriosis. Tissue and peritoneal fluid samples were collected from 95 women with laparoscopically and histopathologically confirmed endometriosis and 59 control women without endometriosis. Expression levels of NGF mRNA and protein were examined using real-time RT-PCR and immunohistochemistry, respectively. Concentration of NGF in the peritoneal fluid (PF-NGF) was measured using ELISA. The degree of dyspareunia and dysmenorrhea was evaluated using a verbal rating scale. Real-time RT-PCR analysis revealed that NGF mRNA was significantly more abundant in the ovarian endometriomas and peritoneal endometriosis than in the normal control endometrium. Immunohistochemical analyses demonstrated that NGF was prominently expressed and preferentially localized to the glands of the ovarian endometriomas and peritoneal endometriosis, whereas it was only weakly detectable in the normal endometrium. Although PF-NGF was undetectable in some normal subjects and endometriosis patients, elevated PF-NGF in the peritoneal fluid was more frequently observed in endometriosis patients with severe pain than in those with less severe pain. Our results suggest that NGF produced locally in the peritoneal cavity may be involved in the generation of endometriosis-associated pelvic pain.Endocrine Journal 07/2013; 60(10). DOI:10.1507/endocrj.EJ13-0027 · 2.00 Impact Factor
Article: Glycodelin in reproduction[Show abstract] [Hide abstract]
ABSTRACT: To achieve a successful pregnancy in humans, sperm is required for capacitation, followed by binding to and entry into an oocyte. Maternal endometrial epithelial cells (EECs) prepare the appropriate implantation environment through regulation of immune cells and endometrial cells. After acquiring endometrial receptivity, a successful pregnancy consists of complex and finely regulated steps involving apposition, adhesion, invasion, and penetration. Glycodelin is a secretory glycoprotein that affects cell proliferation, differentiation, adhesion, and motility. Glycodelin has four glycoforms (glycodelin-A, -S, -F. and -C); differences in glycosylation affect each characteristic function. Glycodelin has a unique temporospatial pattern of expression, primarily in the reproductive tract where glycodelin is mid-secretory phase-dominant. Recent studies have demonstrated that glycodelin protein has the potential to regulate various processes, including immunosuppression, fertilization, and implantation. This review details the orchestrated regulation of successful pregnancy by glycodelin as well as a discussion of the basic characteristics of glycodelin.Reproductive Medicine and Biology 07/2013; 12(3). DOI:10.1007/s12522-013-0144-2
Article: Comparison of the right and left ventricular performance during the fetal development using velocity vector imaging[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Studies on myocardial characteristics examined by speckle-tracking echocardiography are limited. AIMS: To compare myocardial performance between the right and left ventricles during the fetal development using velocity vector imaging (VVI). SUBJECTS AND STUDY DESIGN: Echocardiograms of 95 uncomplicated singleton fetuses (19-36weeks pregnancy) were retrospectively analyzed by VVI to measure global longitudinal peak velocity, strain, and strain rate of both the right ventricle (RV) and left ventricle (LV). The regional values were calculated for three segments (base, mid, and apex) of the ventricular free wall and segment. OUTCOME MEASURES: The VVI-derived measurements were examined for gestational age and compared between ventricles. RESULTS: The global peak systolic and diastolic velocity values of both ventricles significantly increased over gestation examined, whereas the global systolic strain and strain rate were stable (RV: strain -22.6±5.0%, strain rate -2.6±0.7/s; LV: strain -21.5±5.6%, strain rate -2.5±0.7/s). Compared to the LV, the RV showed significantly higher global velocity in systole and diastole (P=0.001 for systole, P<0.001 for diastole). The global systolic velocity of the LV increased close to the RV toward term, whereas the RV was dominant in diastole throughout the examined gestation. Basal strain and strain rate in the RV were significantly greater than that of the LV, although there were no significant differences in the middle and apical values between ventricles. CONCLUSION: Our findings suggest the RV predominance of longitudinal contraction and dilatation, compared to the LV in uncomplicated fetuses.Early human development 05/2013; 89(9). DOI:10.1016/j.earlhumdev.2013.04.015 · 1.79 Impact Factor
Article: β-Catenin Functions Pleiotropically in Differentiation and Tumorigenesis in Mouse Embryo-Derived Stem Cells[Show abstract] [Hide abstract]
ABSTRACT: The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intracellular signaling cascade activated by Wnt. It also plays an important role in the maintenance of various types of stem cells including adult stem cells and cancer stem cells. However, it is unclear if β-catenin is required for the derivation of mouse embryo-derived stem cells. Here, we established β-catenin-deficient (β-cat(Δ/Δ)) mouse embryo-derived stem cells and showed that β-catenin is not essential for acquiring self-renewal potential in the derivation of mouse embryonic stem cells (ESCs). However, teratomas formed from embryo-derived β-cat(Δ/Δ) ESCs were immature germ cell tumors without multilineage differentiated cell types. Re-expression of functional β-catenin eliminated their neoplastic, transformed phenotype and restored pluripotency, thereby rescuing the mutant ESCs. Our findings demonstrate that β-catenin has pleiotropic effects in ESCs; it is required for the differentiation of ESCs and prevents them from acquiring tumorigenic character. These results highlight β-catenin as the gatekeeper in differentiation and tumorigenesis in ESCs.PLoS ONE 05/2013; 8(5):e63265. DOI:10.1371/journal.pone.0063265 · 3.23 Impact Factor
Article: Successful implantation after reducing matrix metalloproteinase activity in the uterine cavity[Show abstract] [Hide abstract]
ABSTRACT: Background: Recently, the concept of recurrent implantation failure (RIF) in assisted reproductive technology has been enlarged. Chronic uterine inflammation is a known cause of implantation failure and is associated with high matrix metalloproteinase (MMP) activity in uterine cavity flushing. MMP activity of women with RIF has been reported to be higher than that of fertile women. In the present retrospective study we evaluated the efficacy of treatment for high MMP activity in the uterine cavity of patients with RIF. Methods: Of the 597 patients recruited to the study, 360 patients underwent MMP measurements and 237 patients did not (control group). All patients had failed to become pregnant, despite at least two transfers of good-quality embryos. Gelatinase MMP-2 and MMP-9 activity in uterine flushing fluid was detected by enzymology (MMP test). All samples were classified into two groups (positive or negative) based on the intensity of the bands on the enzyme zymogram, which represents the degree of MMP activity. Patients who tested positive on the initial test were treated for 2 weeks with a quinolone antibiotic and a corticosteroid, and subsequently underwent a second MMP test. Negative results on the second MMP tests after treatment and subsequent rates of pregnancy and miscarriage were used to evaluate the efficacy of treatment. Data were analyzed by the Mann-Whitney U-test and the chi-square test. Results: Of the patients who underwent the MMP test, 15.6% had positive results (high MMP activity). After treatment, 89.3% of patients had negative results on the second MMP test. These patients had a significantly better pregnancy rate (42.0%) than the control group (26.6%), as well as a lower miscarriage rate (28.5% vs 36.5%, respectively). Conclusions: A 2-week course of antibiotics and corticosteroids effectively improves the uterine environment underlying RIF by reducing MMP activity.Reproductive Biology and Endocrinology 05/2013; 11(1):37. DOI:10.1186/1477-7827-11-37 · 2.23 Impact Factor
Top Journals
Keio University
Edo, Tokyo, Japan
- • Department of Obstetrics and Gynecology
- • Central Institute for Experimental Animals
- • School of Medicine
National Research Institute for Child Health and Development, TokyoEdo, Tōkyō, Japan
University of California, San Francisco
San Francisco, CA, United States
- Center for Reproductive Sciences
Central Institute for Experimental AnimalsKawasaki Si, Kanagawa, Japan
Kyorin University
Edo, Tōkyō, Japan
- • Department of Obstetrics and Gynecology
- • School of Medicine
West Georgia Obstetrics and GynecologyGeorgetown, Georgia, United States
The Jikei University School of Medicine
Edo, Tōkyō, Japan
- Department of Obstetrics and Gynecology
Tokyo Dental CollegeTiba, Chiba, Japan
Fujita Health University
Toyohasi, Aichi, Japan
- Department of Obstetrics and Gynecology


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Strasburg, Pennsylvania Pet Friendly Hotels & Lodging
United States » Pennsylvania » Strasburg
Looking for a hotel in Strasburg, PA that you can bring your pet to? We made sure that each one of the hotels below are pet friendly, so you can enjoy your trip with your pet by your side! Once you have found a pet friendly hotel, you can book your stay instantly from our website or call 866-212-1803 to speak with a pet travel agent.
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290 North Decatur Street - Strasburg, PA (Map)
Pet guests are welcome at pet friendly Amish Lanterns Motel. Each room can have no more than 2 pets. The pet fee is $10 per pet, per day.
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Pet guests are welcome at pet friendly Clarion Inn Strasburg - Lancaster. Each room can have no more than 2 pets which can be up to 50 pounds. The pet fee is $15 per night (maximum $200.00 per stay).
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Will Google Eliminate the Need for Small Business Websites?
Chris Crum
Google has people riled up with its latest local search effort Google Place Pages. Place Pages are a Google Maps feature launched last week, which serve the purpose of providing everything you want to know about a place (a city or a business) in one spot. For example, if you search for a specific restaurant, you should get web pages, directions, reviews, images, street view imagery, business hours, etc. Google lets businesses submit specific categories they want to include.
There is concern from some that Google is trying to eliminate the need for users to leave Google and even visit a small business' web site. WebProNews reader Doug Stewart, who wonders if this is an "assault against the small business website," commented, "Google wants people to spend more time on Google. Yahoo wants people to spend more time on Yahoo. Facebook wants people to spend more time on Facebook. Several of these large online "media" [companies] are doing everything in their power to keep the eyeballs on their website (unless you pay them for an outbound link)."
Do you think Google's Place Pages are good or bad for business? Tell us what you think.
Google has always claimed to do everything with the user's experience in mind. Unfortunately for SEOs and webmasters, however, it also could mean that people have less reason to go to their sites.
To me, this would really depend on the information that the searcher is hoping to acquire. It's going to be about finding the right balance of useful information and providing an incentive to still go to your site (if that is your goal). The Place Pages would certainly bring a new element to the online reputation management table. You're going to want to keep an eye on what's showing up on your Place Page, and address the situation accordingly. They can include user-generated content.
Another concern that has been voiced about Place Pages, is that Google could start ranking them in natural search results – outside of Google Maps. In fact, Erick Schonfeld points out that this is already occurring for at least the Burdick Chocolate Cafe (the example Google used when it announced the feature).
This could theoretically reduce clicks to actual sites, but again, this would just emphasize the need to manage your reputation on your Place Page. Your site is likely to be easily located from the Place Page anyway.
Blogger Eric Fredline says Google's Place Pages are "designed for optimization," but that something is missing. "For one, Google would need local merchant's to define some sort of 'conversion event'. This is conceptually as easy as defining a new 'block type' that will appear on the landing page and be optimized," he says. "For example, a restaurant might view a phone call or an Open Table registration as a conversion event. If it's a phone call, I imagine the merchant could be encouraged to use Google Voice to provide a closed loop analysis of the conversion event."
"Perhaps more likely than having individual merchants doing this (at least in all cases) would be a small army of SEO and SEM experts doing it on the businesses' behalf – but within a closed looped system managed by Google," he adds. "Google could potentially create a whole new eco-system."
Another interesting factor of Google's Place Pages is the fact that they have sponsored results on them. This could raise more concerns, such as competing ads showing up on a business' place page. In Google's chocolate Cafe example, the Page is showing ads for chocolate companies like Godiva and Ghirardelli.
There are a lot of questions about the Pages, and answers will likely come in due time. In fact, Google Place Pages will be discussed in more than one panel at next week's Search Marketing Expo, which WebProNews will be attending. We should have more information on it then.
The Place Pages come with their own structured URL. The example Google gives is http://maps.google.com/places/us/cambridge/brattle-st/52/-burdick-chocolate-cafe. You can see how it is structured by places/country/city/street/address/business name. Google discusses the feature here.
Google says that while not all businesses have a place page yet, they will soon. Businesses can update their info through Google's Local Business Center.
What is your take on the role of Google's Place Pages? Share your thoughts.


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My husband and I stayed for a quick 3 day getaway in August. Took the ferry from Seattle we called ahead and had the shuttle waiting to pick us up. (Not an ordinary shuttle, a Mercedes!). At any other hotel we've stayed check in is always at 3, but when we arrived at 11AM our room was ready! Ate at the on site restaurant The Snug Pub, great food & service! Only a few downsides 1) the spa & pool are open to the public to buy passes. Could not get into the spa the whole time we were there & the pool can be a bit busy. I can see why the locals would want to hang there. It is an amazing view right on the ocean. 2) No gift shop, I had the worst headache & they did not sell aspirin, toiletries ect...
The staff was very friendly, we would recommend this hotel to anyone looking for a peaceful relaxing getaway!
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- The Oak Bay Beach Hotel is a spectacular five-star boutique resort and spa. Enjoy fine dining in The Dining Room, a dinner show or movie in the David Foster Foundation Theatre, hot drinks and housemade treats in Kate's Cafe, pub fare in The Snug (a local legend), or a relaxing soak in one of the three seaside hot mineral pools while watching whales breach offshore. Onsite adventure activities, a sommelier, in-room chefs, catering & conference facilities and event planning also available. Each stay includes: complimentary parking, WiFi, local telephone calls, full access to our seaside hot mineral pools, steam sauna and fitness studio, turndown service and movie channels. ... more less
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"Kalia Law" is Brampton based law firm dedicated to provide customized legal solutions. We have expertise in providing quality legal assistance to myriad issues including property division, family law, immigration, Real Estate and Wills and many more. Our dedicated and experienced attorney strives to deliver unparalleled services and clients satisfaction. Contact us at (905-790-0020) for discuss about your issues and to know about our services.
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1. Re: Map generating algorithm807580 Feb 21, 2010 5:25 PM (in response to 807580)1 - you need to decide on a tile scheme: square, hex, or other.
2 - you need to make tile graphics to fix the terrain you want to support
3 - you need to learn to generate random numbers 0 through N-1 where N is the number of distinct terrain types
Once you have the planning done, you can think about how you want to implement.
2. Re: Map generating algorithm807580 Feb 21, 2010 9:09 PM (in response to 807580)I already have the graphics, and as for the tile scheme, it's square - and at your third point, you kinda lost me...
3. Re: Map generating algorithm807580 Feb 21, 2010 11:42 PM (in response to 807580)Since you are going to be generating a "random board", you will be assigning random numbers ranging from 0 to N-1 to each of your tiles. For instance, if you have 8 tiles, your N will be 8--the number of your tiles, you'll assign a number ranging between 0 and 7 to each of your tiles for your board. For a 10x10 board you'd be doing something along this line:
//warning untested code Tile[][] tile = new Tile[][]; Tile t = null; for(int i=0; i<10; i++){ for(int j=0; j<10; j++){ t = new Tile(); t.type = myRandom.nextInt(8); //what ever assignments you want to give to your tiles tile[i][j] = t; } }
4. Re: Map generating algorithmjwenting Feb 22, 2010 12:26 AM (in response to 807580)Of course in practice it won't be quite that simple as each possible section will no doubt need rules about which other sections can fit on either side of it.
If you don't do that, you quickly run into trouble with totally unrealistic maps.
For example you might have a section that has a river running through it from top to bottom border on something like a mountain or desert with no well, spring, or lake for that river to flow out of or in to.
5. Re: Map generating algorithm807580 Feb 22, 2010 10:01 AM (in response to jwenting)Wow... Sorry, somehow I failed to mention that I'm trying to generate a bunch of randomly generated connecting rooms.
What I've decided to do is create 5-10 pre-built rooms (doors and all) which can all connect to each other (when lined up properly). So I generate a random amount of rooms, then lay them out next to each other. Then afterward creating several randomly generated rooms on the outside of those rooms (so there isn't any doors leading out into an endless void).
6. Re: Map generating algorithm796262 Feb 22, 2010 12:29 PM (in response to 807580)
b1nary wrote:Ok, and why won't the approach already given to you work in that case?
Wow... Sorry, somehow I failed to mention that I'm trying to generate a bunch of randomly generated connecting rooms.


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The 35-year-old Billups "had preferred to enter free agency" and told Yahoo! Sports on Saturday that "he could become a disruptive force if a team claimed him in the waiver process." As Adrian Wojnarowski and Marc J. Spears write, teams figured he was too nice a guy to follow through on his threats.
"After a while, you just kind of get taken advantage of in these situations," Billups told Yahoo! Sports. "I've been known as a leader — and I am a leader — but a leader can be as disruptive as he can be productive, especially when you carry a strong voice and people rally around you. This is about me now. This is about me, and teams should know that right now."
The league was not happy with the comments and informed his agent, Andy Miller, on Monday that his client needed to show up and play for whatever team claimed him, Wojnarowski and Spears report.
The Clippers have also added Caron Butler this offseason and managed to keep young center DeAndre Jordan by matching a four-year, $43 million offer he received from the Golden State Warriors.
Follow Scoop du Jour on Twitter or Facebook.
- Sports & Recreation
- Sports & Recreation/Basketball
- Chauncey Billups
- Los Angeles Clippers
- Adrian Wojnarowski


text: Remember when you first saw the Human Rights Campaign\u0027s logo—the royal blue square with the bold, yellow equals sign that has become synonymous with LGBT rights since 1995, when it was created by the design firm Stone Yamashita? It was everywhere—car bumpers, school binders, even tattoos (just Google it).\u000A\u000AThat little blue square got a lot more famous this week, when HRC\u0027s director of marketing, Anastasia Khoo, had the idea to turn it pink and red, \u0022the color of love,\u0022 in support of the two historic marriage equality cases going before the Supreme Court. At 1 P.M. on Monday, March 25, HRC changed its Facebook profile image and asked its followers to do the same. The word spread, celebrities and major organizations joined in, and now Khoo estimates that Facebook participation is \u0022in the millions.\u0022\u000A\u000AIt wasn\u0027t long before fans started riffing on the logo with their own take on the symbol of love. Here\u0027s a slideshow of our 30 favorites.


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Apple Mac OS X Mountain Lion for Mac
Quick Specs
Total Downloads:100,787
Date Added:Jul. 25, 2012
Price:Purchase; $19.99 to buy
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From Apple: OS X Mountain Lion is the latest release of the world's most advanced desktop operating system. Mountain Lion includes over 200 new features to update your Mac into the best computing experience yet. With the new Messages app you can send text, photos, videos, contacts, web links, and documents to anyone using another Mac, iPhone, iPad, or iPod touch -- you can even start a conversation on one device and continue it on another. The new Share button makes it easy to share files, web pages, photos, and videos, as well as tweet right from the app you are using. With the Reminders app you can create to-do lists and alerts that appear in the new Notification Center. With Notes you can write down all your ideas and even speak your words with voice dictation. Play head to head games on your Mac with friends on their Macs or iOS devices with Game Center. And with iCloud built in, it's simple to keep all your mail, contacts, calendars, reminders, notes, to do lists, music, photos, iWork files, PDFs, and more up to date across all your devices.
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- Place an alarm clock on your desktop and use your audio file...QVIVO is the simplest way to build your personal media cloud...OS X Mavericks is the latest release of the world's most adv...Painting and graphics program like Microsoft Paint.
- Log keystrokes, passwords, IM chats, visited websites, take ...View pictures taken by webcam.Update your mid 2010 iMacs.Unarchive ZIP, TAR, SIT, RAR, and 7-Zip files.


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Way too much stuff to sum up on this, just message me and ask. Love doing just about anything. I Love trying new things and being adventurous. Not into clubbing and bar hopping on a regular basis once in a while is cool but not every night.
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31 • Raleigh, NC • Man
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- Dec 31, 2014
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- 5' 8" (1.73m)
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- Athletic
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Trying to start flipping houses again, while I work my job and go back to school.
I'm really good at
Go on, brag a little (or a lot). We won't judge.
I'm good at alot of sports. Great dancer, have a great sense of rhythm.
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Help your potential matches find common interests.
I like alot of movies and shows and all the above I like to be DIVERSE! I watch most Duke games, as I am a HUGE fan.
The six things I could never do without
Think outside the box. Sometimes the little things can say a lot.
My Dog(Diva), my Family, the Internet, my friends, my car, and t.v.
I spend a lot of time thinking about
Global warming, lunch, or your next vacation… it's all fair game.
Where I'm going in life!
On a typical Friday night I am
Netflix and takeout, or getting your party on — how do you let loose?
Like to do all types of things whatever is going on. Go out stay in I like it all!
The most private thing I'm willing to admit
I'm an empty essay… fill me out!
That I'm on this....before my last relationship I laughed at friends and people that did this, but I don't want to meet people at clubs or bars....
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You want to get to know each other! You know where I log out on this app!
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Bitcoins and scrip oh my!
Blog Archives
Man Held in Solitary Confinement 2 Years After DWI Gets $22M
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He was not allowed a trial. They just stuck him in solitary for 2 years.
Rules of American justice: a tale of three cases
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Feds shut down small mines across Alaska.
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Lawrence O'Donnell says the Republican and Democratic nominee will not represent Libertarians, I tend to agree.
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Hebrew translator corrects numerous misinterpretations.
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Any decent drug dealer could have told them what the outcome would be.
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The Tempest
CreateSpace Independent Publishing Platform, Mar 7, 2010 - Fathers and daughters - 106 pages
In this tale by William Shakespeare, Prospero--the rightful Duke of Milan--has been usurped and, along with his daughter Miranda, has been exiled on an island for twelve years. During this time, Prospero hones his magic, and eventually creates a storm that brings his enemies to the shore of the island he has come to control...
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Amazing imagery and beautiful, poetic language. - Goodreads
The plot is preposterous. - Goodreads
The Tempest is light, quick, and easy to read. - Goodreads
Shakespeare is an amazing play writer. - Goodreads
I thought the Tempest was a very slow pace moving book. - Goodreads
Oh and a love story thrown in for good measure. - Goodreads
Review: The TempestUser Review - Casey - Goodreads
It took me a while to get into this play. And while I finally got a handle on the characters and the overall plot, sometimes I read an entire monologue and had no clue what was just said. At some ... Read full review
Review: The TempestUser Review - Niah - Goodreads
This wasn't bad, in fact, I did enjoy it. I've read a few other works by Shakespeare and really didn't like them. I found this to be a million times better, yet I still didn't love it. Maybe it's the ... Read full review


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Olympia, WAUSA
July 8, 2013
We have a small area here in Olympia, but have more space outside of town. We are near Fertile Ground, where I do some trade.
Not very knowledgeable about much. I've been a massage therapist for the past 12 years, living in the suburbs. I've done some gardening in the past, but it's been awhile.
No answer yet
Hi! Your group sounds great. Many of the things I'm very interested in are what you are all about! I'm new to the area and would love to meet other like-minded people.
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TNT Orders David E. Kelley's Medical Drama 'Monday Mornings' to Series
The drama, based on producer and CNN chief medical correspondent Dr. Sanjay Gupta's book, will premiere in summer 2013 with 10 episodes.
TNT has greenlighted David E. Kelley's Monday Mornings.
The medical series, based on the newly released book by practicing neurosurgeon and CNN chief medical correspondent Dr. Sanjay Gupta, follows the lives of five surgeons as they push the limits of their abilities and confront their personal and professional failings.
Kelley penned the pilot, which uses as its backdrop their Portland, Ore.-based hospital's weekly morbidity and mortality conference, when doctors gather with their peers for a confidential review of complications and errors in patient care. Kelley, whose credits include Harry's Law, Boston Legal and Ally McBeal, and Gupta will executive produce the project, which will bow with 10 episodes in summer 2013.
Mornings, from TNT Originals and David E. Kelley Productions, stars Ving Rhames (Pulp Fiction), Alfred Molina (Spider-Man 2, TNT's The Company), Jamie Bamber (Battlestar Galactica), Jennifer Finnigan (Better With You), Bill Irwin (CSI: Crime Scene Investigation), Keong Sim (Glee), Sarayu Rao (Lions for Lambs) and Emily Swallow (TNT's Southland). The series will be distributed by TBS International outside of North America.
"Monday Mornings is a superb drama brought to life with passion by a gifted ensemble cast and some of the best creative minds working in television today," said Michael Wright, president and head of programming for TNT, TBS and Turner Classic Movies.
The news comes one week before TNT and sister network TBS hold their upfront presentation for Madison Avenue buyers, where it is likely to announce a slew of development projects. Two pilots, Frank Darabont's L.A. Noir and Carol Mendelsohn's canine-centric Scent of the Missing, are still in contention.
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'The Martian's' Matt Damon Talks 'Bourne' Return, Politics and PC Flubs: "Oh My God, I Look Like an Asshole"
The Insane Battle Over Sam Simon's Will — Should the Simpson's Co-Creator's Trust Pay $140,000 Per Year For One Dog's Care?
'Empire's' "Batshit Crazy" Behind-the-Scenes Drama: On the Set of TV's Hottest Show
Hollywood's Notable Deaths of 2015


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hence guerro vs floyd fighting in may!!!
you going to act like Bob Arum didnt cancel and want to move the date to june, knowing floyd had to go to jail!!!
Floyd mayweather even had the judge postponed his jail time to june so the fight can happen!! did you forget all that?? where is your head!! this is all public information!!!
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text:
7 for all mankind
Katie Holmes in 7 For All Mankind Georgia Trousers
Katie Holmes and Suri Cruise headed to a gymnastics class at Chelsea Piers in New York City. Katie wore her 7 For All Mankind Georgia Trousers with a polka dot top, boots, and a Loewe Paseo handbag.
It has been quite some time since we've seen Katie in these jeans, she used to wear them quite frequently. We've been seeing her out in these for a few years, but they still look as relevant and current now as they did the first time we saw her in them. You can buy 7 For All Mankind jeans online from Shopbop.com.
Images from Pacificcoastnews.com
Sarah Michelle Gellar in 7 For All Mankind
Sarah Michelle Gellar shields her face from the paparazzi while she was out running errands in LA. Sarah wore a pair of 7 For All Mankind skinny jeans with a white tank and Rag & Bone boots.
I think that this outfit is such a great casual outfit, I think all of the pieces work together without being too fussy. Sometimes it is great to see just a simple look, that is not too over thought. You can buy 7 For All Mankind jeans online from Shopbop.com.
Cory Monteith in 7 For All Mankind Austyn Relaxed Jeans in Chester Row
Cory Monteith and girlfriend Lea Michele were seen catching a flight together out of LAX. They were later seen in New York City having lunch with Lea's parents.
For his trip, Cory wore a pair of 7 For All Mankind Relaxed Straight Leg jeans in Chester Row with a gray sweater and green coat. We've seen Cory in a lot of different brands like Citizens of Humanity, Joe's, Nudie and Cult of Individuality. I'd love to see him in a great pair of Diesel jeans, I think they'd suit his style really well. You can buy these jeans online from 7 For All Mankind for $169.00.
Images courtesy of Pacificcoastnews.com.
Kourtney Kardashian in 7 For All Mankind Skinny Jeans
Kourtney Kardashian and son Mason were snapped out at a park in Miami. Later in the week, Kourtney and the rest of the Kardashian's celebrated Mason's 3rd birthday.
It's been a while since we've seen Kourtney in a pair of 7 For All Mankind jeans! Usually she wears her Bleulab's. She wore a pair of 7 For All Mankind skinny jeans with combat boots and a simple white tee shirt this time. You can buy 7 For All Mankind online.
Images from Pacificcoastnews.com


text:
David Roentgen (German, 1743–1807)
Oak, pine, walnut, cherry, tulipwood, and mahogany (later drawers), veneered with maple, hornbeam (both partially stained), tulipwood, burl wood (stained), mahogany, holly, walnut, and other woods; gilt bronze, brass, steel, and iron; marble; partially tooled and gilded leather; 44 7/8 x 45 3/4 x 26 1/2 in. (114 x 116.2 x 67.3 cm)
Gift of Samuel H. Kress Foundation, 1958 (58.75.55)
The Roentgen manufactory was particularly well known for its rolltop writing desks with four, six, or even eight legs, distinguished in the 1770s by the accomplished marquetry á la mosaïque (also known as "painting in wood") and gilt-bronze mounts that decorated their exteriors. The marquetry motif on this example, which occurs elsewhere on Roentgen furniture, depicts flower and leaf bouquets twined around a pointed planting tool along with ribbon-tied pruning knives. The juxtaposition of what is probably a seeder or hoe with the pruning knives and bouquets constructs a narrative for the flowers that follows them from planting to harvest. The architectural interior of the desk contains pigeonholes and drawers, with fronts in striped tulipwood stained green and brown and handles shaped like lion masks holding small gilded rings. This desk was damaged, requiring major repairs. The front legs, originally detachable, are stationary replacements that cannot be unscrewed. Both lower side drawers are also replaced, with floral marquetry on the drawer fronts that is not by David Roentgen or by any master in his workshop. The desk may have been forced open, causing irreparable damage to the veneer and surfaces, the locks and inner spring mechanisms, the body of the drawers themselves, and even the front legs. It is a testament to Roentgen's unmatched skill that the desk and its complicated locks were so difficult to penetrate as to cause such damage and that the later restorer could not replicate his advanced designs.


text: landlord/tenant Landlord/tenant laws, issues, and disputes By Chuck Finney • Mar 18, 2015 Landlord/tenant laws, issues, and disputes.Guests: Landlord/tenant attorneys James Coy Driscoll and Marc Seidenfeld.Listeners with questions for Chuck's on-air guests, please call 415-841-4134.Also, we will host a special Landlord/Tenant Call-A-Lawyer Night this evening. Attorneys will be on hand to take landlord/tenant questions off-the-air during Your Legal Rights, 800-525-9917, between 7 & 8pm. Landlord/tenant laws and issues By Chuck Finney • Feb 26, 2014 Landlord/tenant laws and issuesGuests: Landlord/tenant attorneys James Coy Driscoll and Marc SeidenfeldListeners with questions for Chuck and his guests, please call 415-841-4134.Also, February 26 is our once-a-month Call-A-Lawyer Night. While Your Legal Rights ison-the-air, 7-8pm, we invite you to call our off-air number with questions on any law topicthe attorneys there are prepared to discuss: 800-525-9917 for your private consultation.


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Adele - Page 2
Adele to Perform 'Skyfall' at Oscars
Adele's Music May Put You to Sleep
Adele Announces She's A Mom! [VIDEO]
Have you ever noticed that some celebrities put their private life on display for everybody to see, while others keep a tight reign on personal matters. Adele is very much in the second group.
Adele 'Skyfall': Listen to Snippet of Bond Theme Song
Adele just announced that she's a "Bond Girl" and that she would be premiering 'Skyfall,' the theme song she recorded for the upcoming 007/James Bond film of the same name, and already, a minute-and-a-half snippet of the song has leaked online. So what's the verdict?
Listen to Adele's James Bond Theme Song 'Skyfall'
Just this morning, Adele officially confirmed the rumors that she would be singing the theme to 'Skyfall,' the 23rd James Bond film, when she tweeted a photo of the official sheet music. And now you don't have to wait very long to listen to 'Skyfall' by Adele as audio has leaked from the upcoming Bond theme.
Kelly Clarkson Covers Fellow Powerhouse Adele With 'Someone Like You'
Kelly Clarkson and Adele have two of the best voices in music today (and possibly ever). So when Kel covered 'Dele live, two things could have happened: Either it would be amazing or the universe would implode. Thankfully, this resulted in the former.
Adele Calls Out Stars for Using Sex to Sell Music
Adele, who is pregnant with her first child, doesn't rely on having to cultivate an overtly sexual image or shilling perfume in order to sell records. She has repeatedly stated that she doesn't want to be a pop star or any sort of sex symbol. But now, she is taking pop stars who get a little too salacious in their videos and performances to task.
Adele's Pregnancy Inspires Her to Take 'Lighter' Approach to Third Album
Adele Hits Abbey Road Studios to Record Theme Song for James Bond Movie 'Skyfall'
Did Adele Get Married?
If You Named A Baby After A Celebrity, What Name Would You Choose?
A lot of popular names today come from celebrities or possibly the roles they play in a movie.


text:
Narrow your search
"A lot of core gamers hear free-to-play and it's like feeding a child asparagus."
The former Reddit CEO Yishan Wong takes to the popular news site to reveal more details in what has evolved into a corporate soap opera.
Feel the fear with a heart-pumping, action-packed HoloLens demonstration that has a dude named Dan defending an event stage from robot invaders.
The Defense Department is expected to announce a modification to the nation's strategy that will result in the use of cyberattacks as a defense tactic.
In his latest public question-and-answer session, the social networking giant's CEO discusses public policy, Internet expansion and other topics.
The "Harry Potter" author gently responds to a fan on Twitter who "can't see" Hogwarts' headmaster being gay.
Trialing might be the purest expression of passion for the Land Rover Defender -- man and machine pitted against nature in a muddy arena. XCAR got their hands dirty.
The Defender Challenge is a new racing series that sees the might of the Land Rover Defender conquering some of the most challenging stages in motorsport.
Fashiontech designer Anouk Wipprecht has updated her personal space defensive Spider Dress with Intel Edison and 3D printing.
We spent five hours with the newest multiplayer version of Metal Gear.


text:
Stepping Stones of Western Europe
April 23-May 1, 2016
Experience the rich history of France and Great Britain on this seven-night cruise from Bordeaux to London aboard the Five-Star M.S. L'Austral. Travel to five UNESCO World Heritage sites, cruise up the River Thames and visit the beaches of Normandy with special guest Dwight D. Eisenhower II. Book by Oct. 8 and save $2,000 per couple!
NEW - Members Save at the National Aquarium
Located in Baltimore's Inner Harbor, the National Aquarium is home to more than 20,000 animals in award-winning habitats. Meet a 500-pound green sea turtle, explore the colorful sights and sounds of a tropical rain forest and descend to the depths of shark territory—all at a discounted price.
Hosting an Event?
Members of the Alumni Association receive 15% off event rentals and packages at the Riggs Alumni Center. You'll find what you need, whether you're planning a banquet, conference or once-in-a-lifetime celebration.
Alumni Advising Network
Maryland alumni and students can now connect directly with alumni advisors online for free career advice, coaching, resume support and interview prep.
Alumni Zone Open House
Stop by the Samuel Riggs IV Alumni Center before every home game to gear up with your fellow Terps. Free to the public, the Maryland Club will be open for drinks—with popcorn for everyone!
Sept. 12: Bowling Green
Sept. 19: South Florida
Sept. 10
Annapolis: Neighborhood Meet and Greet
Sept. 16
New York: Women's Networking and Wine Tasting
Sept. 19
South Florida: Service, Sports and Students Weekend
Sept. 20
Latino Alumni Network: End-of-Summer Cookout
Sept. 23
Webinar: Travel to Machu Picchu
Sept. 26
Southern Maryland: Crab Feast and Museum Tour
Check out the full listing of September events.
Renew, upgrade or extend your membership with the University of Maryland Alumni Association by Nov. 7 and you'll be automatically entered to win a 2016 Ford Fusion hybrid! For official rules, visit alumni.umd.edu/join.
The Kojo Nnamdi Show: Reimagining College Park
The New York Times: Under Armour Seeks to Do for Maryland What Nike Did for Oregon
The Washington Post: Terp Says He'll Eliminate Chronic Pain with a Simple Device
UMD Named a Top 25 LGBTQ-Friendly University by Campus Pride
The Best Sports Recovery Drink May Not Be What You Think
Stay active. Stay informed. Stay Connected.
How do you stay fearless? Share your pictures with us on social media!
Send your funniest UMD
stories, whether
they involve awkward roommate
or getting lost on your way to class, to
email@example.com for a chance to win
a free T-shirt!
Samuel Riggs IV Alumni Center / College Park, MD 20742-1521 / 301.405.4678 / 800.336.8627


text:
Добрый день, направляемся в этот отель в четверг. подскажите, пожалуйста, во сколько обходится такси до Сохо (центра)?
Sherif Leon
General Manager - Jaz Belvedere Resort
Dear sir,
Let me introduce myself. My name is Nikolay, and I was a guest in your amazing hotel from 27th of April till 11th of May. My room number was 1416. It was unbelievable time, and I have a desire to say you Thanks for my holidays. It will be pleasure for me to recommend your hotel with such a high service to my friends and relatives.
If you find an opportunity to make me a little favor I will do appreciate it very much. I do not remember an exact date, but me and my girlfriend had a photo session in your hotel with your local photographer at 8th of May or at 9th of May. Finally a photographer gave us a CD with our beautiful photos, but unfortunately we broken it during our flight to Moscow. We want ask you to connect with this photographer and send us these photos to my e-mail address. It would be a very kind step from your side. Thank you again for your attention, looking forward to hearing from you as soon as possible!
My e-mail address: pilav-nk @ mail . ru
Best Regards,
Nikolay Pylaev
It is unfortunate that you can not solve this unpleasant incident of theft at your hotel and catch the thieves of money, because in this case the theft will go on and on...
Excellent hotel, but... Stayed in JAZ BELVEDERE HOTEL 5* (Sharm el-Sheikh) from 1 november 2014 to 8 november 2014. Lived in building №16. At 9 november 2014 on arrival home found that the amount of money which stored in a closed room's safe lacked $300. It is surprising that in hotel that pretend to be a strong 5 stars simply can't solve the problem of theft. In these circumstances all the impression of a very nice hotel instantly disappears... We would like to advise JAZ BELVEDERE HOTEL in Sharm el-Sheikh for guests from Russia and other countries of the world, but... it is unfortunately impossible, sorry. After the theft situation was conveyed to general manager of hotel JAZ BELVEDERE, the response was amazing. Said simply: electronic room safe without knowing the password is impossible to open, and that's it...
Показать все вопросы


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Product Index > Sensors, Transducers > Accelerometers
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Home » Photography » It's in the Details – Emmy Lou Virginia
It's in the Details – Emmy Lou Virginia
James Pond August 19, 2011 Photography No Comments
For Emmy Lou Virginia, photography is a way of remembering beauty – "Sometimes, I imagine that my eyes are a camera. The couple carrying shopping bags blurs out of focus, and the discarded shoelaces straggling across the sidewalk become black and white, and the girl's hair is moving in slow motion to the wandering wind, and I feel the need to save this, this loveliness that only I can see."
About The Author
I am the owner of Pondly.com / art lover / electrical engineer / software developer / MBA in e-business student. I blog for pleasure and love to share my Internet findings.
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