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Items tagged with Madden NFL 15
Seattle Seahawks coach Pete Carroll made the wrong call at the end of Super Bowl XLIX and potentially cost his team from being crowned back-to-back champions, though it played out almost exactly as simulated in Madden NFL 15 on the Xbox One, which correctly predicted the final score and winning team a week prior to the big game -- 28-24 in favor of the New England Patriots.In doing so, Electronic Arts' Madden franchise improves its record to 9-3 in annual Super Bowl simulations. That's impressive in and of itself, though this is the first time in a dozen Super Bowls that EA's football simulation... Read more...
Despite all the distractions over pigskin bladders this past week, the New England Patriots will be prepared for the staunch defense of the Seattle Seahawks and win Super Bowl XLIX, with quarterback Tom Brady earning the MVP award. So says Madden NFL 15 in an annual simulation that Electronic Arts has been doing for over a decade. It's worth bringing up that the annual Madden simulations have put together a record of 8-3 up to this point. Impressive, though not without some embarrassing misses, like predicting a Denver Broncos victory over the Seahawks last year to the tune... Read more...
Looks like Electronic Arts is not holding back this year with its sports games. The video game publisher is expecting to make around $1 billion in revenue from downloadable content and is also taking steps to crack down on cheaters for its various sports titles. Madden NFL 15 is one of the key games to EA's strategy. Aside from players paying $60 for the standard game, EA is pumping out a plethora of add-on content such as Ultimate Team players, jerseys, coaches, playbooks, and stadiums. The Madden Ultimate Team packs, which can be purchased with Madden Points, are a huge moneymaker for EA... Read more...
If you're the type to gamble on a rumor, then you might want to wait before pulling the trigger on an Xbox One console. Your patience could be rewarded with a free game, that is if talk of two upcoming bundles turns out to be true. One of the bundles that's said to be in the works will include EA's Madden NFL 15 title with the Xbox One, along with a code for three Team packs (DLC). According to Fudzilla, this is for the discounted $399 Xbox One that doesn't come with an Kinect motion control sensor. It does, however, come with an Xbox One controller in black, and of course the console itself. Assuming... Read more...


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|ISSN 1088-6826(online) ISSN 0002-9939(print)
The complement of the stable manifold for one-dimensional endomorphisms
Abstract | References | Similar Articles | Additional Information
Abstract: Let denote either the circle or the closed interval and let be a endomorphism of . Let be the complement of the union of the stable manifolds of the sinks of . In this paper we give necessary and sufficient conditions for to consist of eventually periodic points.
Retrieve articles in Proceedings of the American Mathematical Society with MSC: 58F12, 54H20, 58F20
Retrieve articles in all journals with MSC: 58F12, 54H20, 58F20
Additional Information

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May 05, 2015
Boston Marathon bomber's lawyer points to family dysfunction
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Chocolate Covered Apricot Bites
I was invited to guest post on the Original Eating site recently, and I wanted to share my recipe and the blog with you!
Spring has sprung! The sun is shining and the birds are singing. It's such a beautiful time of year here in Central California. It's really my favorite time (but I think I say that about all the seasons). It's still cool at night, but warms up nicely during the day, just lovely!
Spring is definitely the time of new beginnings and it is for me also. I got married recently it hasn't even been quite a year yet, so we are still newlyweds and it's been a very exciting year! We're having fun getting to know each other better as we settle into our married lives and one thing I know my hubby likes is sweets! (I call him my Sweetie and somehow that just seems to fit).
I've really never been into sweets, but because I know it's something he really enjoys so I've been trying to make them more. I've also been trying to make them healthier, but I won't sacrifice flavor either. Sometimes that makes it tough.
I was thinking about what I could make, a recipe to share and I thought of something my good friend Tracy makes and thought hmmm…. let's just see what happens when we mix things up a bit! Here's a fabulous new treat for you and it's well…just full of yum!
Chocolate Covered Apricot Bites
Here's everything I started with; walnuts, apricots, vanilla, orange, cocoa powder, salt, honey and chocolate chips. That's all you need to make this fabulous dessert!
First I took a cup of walnuts, tossed them in the food processor and whirled them around. They were very finely chopped.
Then after I assured myself they were as chopped as well as they could be, I gave them another pulse or two. Seriously, I did!
Then I added dried apricots, orange zest, salt and cocoa powder. Again I pulsed and whirled the food processor, chopping them as finely as I could.
When they were completely chopped, I added honey, vanilla and fresh squeezed orange juice, one tablespoon at a time. You may not need all three tablespoons, it really depends on how much moisture is in the apricots.
Test the dough, when you are able form the mixture into little squares, it's nearly ready.This makes up the centers of the Chocolate Covered Apricot Bites.
Transfer the mixture into a small bowl. Cover it with plastic wrap and tuck it into the refrigerator an hour.
Use about one tablespoon for each bite and firmly press them together. Because of all the natural oils in the apricot and nuts, you'll need to squeeze some oil out and that's ok.
Just prep them into little squares like so. When you are done, put them back in the refrigerator for about two hours. They will harden up and be ready to be dipped into chocolate.
Fast forward two hours and it's time to melt the chocolate! Put a heat proof glass bowl over a pan of hot simmering water on the stove, (don't let the bottom of the glass dish touch the water). Add the chocolate chips and slowly stir to melt the chocolate until it becomes a smooth consistency. Remove it from the heat and now you're ready to begin coating the apricot melts!
Put them in the chocolate one at a time and use two forks to flip them over. Forks work really well because the excess chocolate will drain through the tines of the fork. Flip them over and coat them on all sides. Place the Chocolate Covered Apricot Bites on a sheet of wax paper to harden.
I took several pictures because let's just face it they are pretty!
Tuck them into the fridge when you're done.
My brother was here for taste testing and he decided their name should be UFO's Unidentified Flavor Objects. When you're tasting them you're thinking what flavor is that? What am I trying? And my favorite comment he made was this is really good!
If you want to (and I'd encourage it) decorate the top with sea salt or some sliced almonds. Personally, I prefer them topped with salt. There's something about the combination of chocolate, apricots and salt that makes them super delicious!
Store them in the refrigerator. They absolutely melt in your mouth!


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BBB Accredited Business since 04/27/2005
Mosquito Squad of Charlotte, Inc.
(704) 821-0805View Additional Phone Numbers4050 Mathews-Indian Trail Rd., Matthews, NC 28104http://charlotte.mosquitosquad.com/View Additional Web Addresses
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A BBB Accredited Business since 04/27/2005
BBB has determined that Mosquito Squad of Charlotte, Inc. meets BBB accreditation standards, which include a commitment to make a good faith effort to resolve any consumer complaints. BBB Accredited Businesses pay a fee for accreditation review/monitoring and for support of BBB services to the public.
BBB accreditation does not mean that the business' products or services have been evaluated or endorsed by BBB, or that BBB has made a determination as to the business' product quality or competency in performing services.
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Factors that raised Mosquito Squad of Charlotte, Inc.'s rating include:
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- Resolution of complaint(s) filed against business.
Customer Complaints SummaryRead complaint details
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1 Customer Review Customer Reviews on Mosquito Squad of Charlotte, Inc.
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This company is in an industry that may require licensing, bonding or registration in order to lawfully do business. BBB encourages you to check with the appropriate agency to be certain any requirements are currently being met.
These agencies may include:Agriculture & Consumer Services, NC
2 W Edenton St
Raleigh, NC 27601-1020
(919) 733-7125
BBB records show a license number of Cert. #026 for this company, issued by Agriculture & Consumer Services, NC. Their web address is http://www.ncagr.com/index.htm.
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Incorporated: November 2004, NC
Contact InformationPrincipal: Ms. Casey Johnson (Owner) Randy Peck (Owner)
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Christopher DeMuth writes:
"My article 'A Constitutional Congress?' (Oct. 27) mistakenly said that the 1974 Budget Act was enacted over Richard Nixon's veto. I was following secondary references, and have been straightened out by a sharp member of the Senate historian's office. Nixon signed the bill on July 12, 1974, when his congressional support was crumbling but he was still holding out hope of avoiding impeachment (the Smoking Gun Tape was released Aug. 5 and he resigned Aug. 9). He had strongly opposed the Budget Act, but it had passed the House by 401-6 and the Senate 75-0. It was not the time for a symbolic act of defiance."
Pakistani national Shahawar Matin Siraj and a friend, Irish-Egyptian-American James Elshafay, went to the Herald Square subway station on 34th Street in New York City on August 21, 2004, shortly before the quadrennial Republican National Convention was scheduled to begin nearby. Siraj and Elshafay were no ordinary commuters. They wanted to determine, as precisely as possible, the exact location on the subway platform where a bomb would inflict the maximum amount of damage. They even made diagrams of the station outlining their murderous designs.
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My School Daze at Berkeley
It's been many, many moons since I left the comforts of the post-dorm townhouse I shared with three of my college friends in the East Bay – or so it seems. It was the start of summer, and instead of heading home to L.A. after graduation, I decided to stick around and enjoy the first several weeks of my carefree summer with my friends for as long as possible until it was time to pack up for my move to Chicago. The irony is that I rushed to graduate from college so that I could "get on with my life", earning my beloved English degree in three years instead of four, but when it was finally time to turn the page from my life's undergraduate chapter, I didn't feel quite ready; I wondered if I'd rushed things. More


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ST. PETERSBURG, Fla. -- Hickory Crawdads second baseman Ryan Rua has a Minor League-best 28 homers and sits atop the leaderboard for the Joe Bauman Home Run Award, presented by Musco Sports Lighting. The top regular season home run hitter in the domestic-based leagues wins the Joe Bauman Trophy and a check representing $200 for each one he hit.
The 23-year-old Rua has a two-homer cushion over Joey Gallo, his Hickory teammate, and Oklahoma City outfielder George Springer, who hit 19 for Corpus Christi, before being promoted to Triple-A. Buffalo's Mauro Gomez is three back with 25. Chris Colabello (Rochester), Robby Hefflinger (Lynchburg/Mississippi) and Ernesto Mejia (Gwinnett) each have 24 homers.
Classification leaders, provided they are not the overall winner, receive a $500 cash award. Gomez has a one homer lead over Colabello and Mejia in Triple-A. Brock Peterson of Memphis is three behind Gomez with 22. Louisville first baseman Mike Hessman, the active leader in career Minor League home runs with 385, has 21.
Matt Fields of Northwest Arkansas paces Double-A with 23 home runs, one more than Xavier Scruggs of Springfield. Kiel Roling (Tulsa) and Springer each have 19. Brett Nicholas (Frisco) and Ryan Schimpf (New Hampshire) are six behind Fields with 17.
Rua and Gallo, who won the Class A Short-Season/Rookie-level classification prize with 22 home runs last year, are 1-2 in Class A. Hefflinger and Max Muncy, their closest pursuers with 21 homers, are both in Double-A. Inland Empire's Michael Snyder has 20.
Jamestown first baseman Danny Collins leads all Class A Short-Season and Rookie-level players with six home runs, one better than nine other players.
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23 November 2013
Global Entrepreneurship Week is the
world's largest celebration of the innovators and job creators who launch
start ups that bring ideas to life, drive economic growth and expand human
welfare. Every year in November GEW....
On November 23rd, a conference to
commemorate the Somali chapter of the Global Entrepreneurship Week was held at
Maansoor Hotel in Hargeysa, Somaliland with a wide range of participants in
Shaqodoon organizes regional
employment conference
24 April 2014
Shaqodoon Organization with support
from Save the Children International (SCI), held two inclusive youth employment
conferences in Borama (AWDAL) at Rays Hotel, and Barwaqo Hotel, Berbera, Sahel
region. The main...
Ahmed Ali Jama is a program specialist at Shaqodoon,
the official GEW Somalia host organization. Over the course of the last
eight months, he has run a successful training program for hundreds of
Registration of 6,000+ out of work and hard to reach youth
31 December 2013
of hard to reach youth in selected districts in Somaliland has begins on 31st
December 2013. The aim of the registration is to register 6,000 out of work and
hard to reach youth to connect them information on...
Mobile Technology To Support Democracy Building
21 May 2013
Shaqodoon Organization held a workshop on 21th
May to present the feedbacks data analysis they received from both
domestic observers and public people from across the country on the
Election Day and also indicate how mobile...


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Just checked out and we miss Jolene, Gary and their lovely B&B already! We spent 3 nights there during out first trip to Costa Rica. Our hosts made us feel safe and comfortable immediately. Their tour and dining tips were bang on. They went out of their way to be available for their guests. Their son is a close by resource for many activities. We were lucky enough to see lots of marine life including dolphins, turtles and sting rays during our boat trip with him. Our room was comfortable and well decorated. What can we say the pancakes were the best we've had. Our favourite was the tropical which included coconut and macadamia nuts......and chocolate chips were optional.
K&P from Canada


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Trulia updates sometimes take a bit to process. If it is still up in 48 hours, I would contact Trulia customer support. If you appreciate an answer, please give t ... more
I am sorry to hear that. I would recommend consulting with a real estate attorney. Typically apartment complex managers usually know a few good ones that they've used in th ... more


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When trying to decide where to invest your money, the ever-changing nature of the world's investment markets makes finding the future homes for your investment funds a tough job. What is a great investment today might be something to run from next week. It's not hard to find opinions about the best investments, but what about the worst?
TUTORIAL: Investing 101
Consider cash as any money sitting in a zero-interest bank account. In an investment market that is rapidly weakening, not losing money is key and that's where cash is king. For any other reason, cash guarantees you zero positive return.
Certificate of Deposit
The interest rate for a five-year certificate of deposit (CD) is around 2%. If the average rate of inflation is 3%, you are actually losing 1% by tying your money up for five years. Although a CD is safe, too much safety doesn't allow your money to work for you. (Certificates of deposit promise stable income in any market, but do they deliver? For more, see Are CDs Good Protection For The Bear Market?)
Real Estate
It was only a few years ago that real estate was making people rich in a small period of time. Now, with home prices down more than a national average of 32% since their peak in 2006, investors should steer clear of the real estate market until clear signs of life emerge.
Timeshares makes sense for only a small sector of the population. If you plan to vacation in the same resort every year and want to lock yourself into payments which include upkeep on the resort that you will only see a couple of weeks each year, a timeshare is for you. It's also next to impossible to make a profit even if you can sell the share. Most real estate agents don't want to work with clients trying to sell a timeshare and, for those who do, commissions can be as high as 30%
Life Insurance
There are many products marketed as investments that are based on an insurance policy, including life insurance. Life insurance should be purchased as an insurance policy that pays the beneficiary if you die. It doesn't have to be any more complicated than that. If you're looking for an investment vehicle that pays a fixed amount, look at bonds or dividend paying stocks. (The most difficult aspect of this complex product is determining how much coverage you need and why. For more, see Top 10 Life Insurance Myths.)
Penny Stocks
Just because a stock is cheap doesn't make it a good investment. Think of a stock like anything else you would buy. If it's in the bargain bin, it's probably because investors don't want it. You will make more money buying a few shares of a high quality company rather than a lot of shares of a low-quality name.
Although trading in the options market can yield big gains, it's not for the part-time investor due to the high volatility. Stay with quality stocks until you have the training and experience to trade in this market.
To say that treasuries are a bad investment may sound anti-American but treasuries pay a lower rate of return than a certificate of deposit. There are a multitude of fixed income investments that pay better returns than treasuries.
Financial Stocks
Financial stocks led the market down in late 2008, and since then, they haven't given investors much cause for excitement. The XLF, the exchange traded fund that tracks the performance of the financial sector has lost 80 cents since August 2009, and many stock market analysts believe this trend will continue for the coming years.
For longer term investors, financial stocks represent a great buying opportunity, but for those with a five-year horizon, that may not be long enough to make money. (For more on ETFs, see Using ETFs To Build A Cost-Effective Portfolio.)
TUTORIAL: Stock Basics
The Bottom Line
Investment markets exist because there are people who like a certain investment, and there are people who hate it. It is this difference of opinion that creates both buyers and sellers. Any one of these investments may actually be appropriate for you, so make sure to evaluate each using your own standards.
Personal Finance
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Home & Auto
Under the Tuscan Sun: Buying a House ThereA look at the real estate trends, what you can expect to pay and, yes, some sample listings.
A Look at 6 Leading Female Value InvestorsIn an industry still largely predominated by men, we look at 6 leading female value investors working today.
How to Save Money on Your Disney VacationUnderstand why Disney Parks are attractive vacation destinations and why they are expensive. Learn five money-saving tips for Disney vacations.
Small Cap Investing: How to Think About IlliquidityDo your homework, have a long term view, exercise patience, you'll find that investing in small market capitalization stocks is no riskier than investing in large stocks
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3 Low Volatility ETFs to Ride Out Market TurmoilVolatility is part of the current environment, but that doesn't mean investors can't be safe and also capitalize. ETFs can be a great defense.
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10 Tips for Renting a Vacation Home on AirbnbHere's a list to make sure that you have a seamless vacation using Airbnb.
Investing Basics
How to Make Small-Caps Win for Your PortfolioSmall-cap stocks can offer generous returns, but you need to know how to find the right ones. Here's a little help.
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Beach House Investing: Best Beach Towns in North CarolinaFind out about some of the most popular coastal cities in North Carolina for individuals considering beach house investing in the state.
Stock Analysis
3 Small-Cap Stocks Poised for Large ReturnsThese three small-cap stocks have significant upside potential, but their risk/reward ratios vary.
Do penny stocks pay dividends?Because of the small market capitalization and revenues typical of most penny stocks, there are very few that offer dividends. ... Read Full Answer >>
Can you buy penny stocks in an IRA?It is possible to trade penny stocks through an individual retirement accounts, or IRA. However, penny stocks are generally ... Read Full Answer >>
Where do penny stocks trade?Generally, penny stocks are traded through the use of the Over the Counter Bulletin Board (OTCBB) and through pink sheets. ... Read Full Answer >>
Where can I buy penny stocks?Some penny stocks, those using the definition of trading for less than $5 per share, are traded on regular exchanges such ... Read Full Answer >>
Why would you undertake a reverse split?Most reverse stock splits are undertaken by small, micro penny stocks that need to maintain the minimum price requirements ... Read Full Answer >>
Why would a company perform a reverse stock split?A company performs a reverse stock split to increase its share price. The desire to increase the share price is usually driven ... Read Full Answer >>


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When North Central High graduate Devin Lee and his wife and Lugoff-Elgin graduate, Nikia Knox-Lee, purchased the Palmetto State Rizers, they said it was important that they try and give the American Basketball Association franchise a presence in their home county.
CHAPIN -- Given the chance to use an escape clause, which was losing starting quarterback Josh Council with three winnable games left in the Region 4-AAA season, Camden head coach Jimmy Neal refused to play with "what if" card.
COLUMBIA -- If effort somehow equaled victories, then Lugoff-Elgin may have gotten their first win of the season on Friday night at Harry Parone Stadium.
You don't become aa successful a coach as Paige Wilson is by leaving things to chance.
North Central will host its first state playoff game since the 1994 season when the Knights welcome arch-rival Andrew Jackson to Boonetown for Friday's first round AA Division II Upper State contest.
Louis Clyburn has been told by several people about when, in 1984, North Central played and lost a game to eventual state champion Woodruff, 34-7, in the third round of the state class AA playoffs.
Nothing to win. Nothing to lose.
It would be easy for Camden and head coach Jimmy Neal to look to the heavens and ask, "Why us?"
When you have played nine games and have nothing to show for your hard work and effort on Friday nights, it is not easy to return to the practice field the following Monday.
With one last chance to get that first victory, Camden Military Academy head football coach Will Rice tried to tug at his players' emotions for Saturday's season finale.
Of all the times for an injury to strike, this was the worst.
Early last week, North Central head coach Louis Clyburn was feeling pretty good about his team's ability to host a first round state playoff game with a victory in either of the Knights' final two regular season games.
The destiny of a football team sometimes has an interesting way of revealing itself.
Who could have blamed Westwood for looking a bit confused as they took the field for the final play of the game on Friday.
This is one game ball which Camden head coach Jimmy Neal wants the referee to return to him after the final horn sounds.
Page 48 of 90
Even though her team may have jumped into the driver's seat when it comes to the Region 4-AAA volleyball standings, Camden head coach Paige ...
When you have multiple teams sharing a pair of stadiums, as do football programs in Richland Districts 21 and 2, you are bound to have ...
It was a trade-off over which Jimmy Neal had no control.
Call it the Chicago voting style of ailments.
By TOM DIDATO
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Hotel Gerbi
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Room service
- Swimming pool
- Restaurant
- Beach
- Wheelchair accessibility
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TripAdvisor Reviews Hotel Gerbi Weggis
Travel Blogs from Weggis
Cheese, culture and great scenery
... the pope and the vatican but didn't realise the background behind it. Anyway, when the French revolution broke out the royal family fled but the guard stayed behind to give the impression of protecting the palace and of course the royal family. When things all went to custard and the palace was over run unfortunately all but a few of the guard were killed. The statue in the side of the hill is that of a Lion that is dying with a spear through it. It is actually ...
It takes a village
... with a wood stick. I heard Jesse calling from the top that they were closing down the gondola and we had to leave right away. The thought of hiking down that mountain alone with three kids put me in scramble mode. We made it in time to ride vs carry a tired two year old and scrambling cousins down a ski slope. The zippers all had fun with a few bruises resulting from the ropes.
Our reservations that night at an Italian restaurant proved to be a good ...
My second week in Switzerland
... the time. Parents come here to let their kids run wild, while they catch up on some much needed sleep on the giant pillow. Chinese for lunch, was really good. We all went home to my grandparents and it was nice that all of us could be together. Ate some of my grandfather's home made eggplant lasagna, which was so delicious. I'm thankful I have a strong will or I would have long, stuffed myself to the brim. Postcards and packages were the main focus of ...
Leaning tower of lamp
... We were stuck in traffic before the largest tunnel in Europe, that would get us through the mountains. All of a sudden we look out the window to see Richie running down the street. He'd jumped out to go get some water. Free from the tunnel we got to take in the spectacular sights that was Switzerland. The beautiful scenery and icy blue water. Sadly someone was playing a horrible music playlist with one ...
Finally I arrive at the conference
... New Zealanders already and the shock of talking and socializing so much after a fairly solitary week of holiday is quite something! I know , however, that I am about half and half introvert and extrovert, so I should be able to make the switch! I am so grateful that I paid the supplement for my own room so that I can get space when I need it. Tonight's presentation was by Luk Bussiere, the regional director for Assockiation of Christian ...


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Drury Inn & Suites Indianapolis Northeast, Indianapolis
- Free hot/cold buffet breakfast, free WiFi, and free parking
Main amenities
- 210 smoke-free guestrooms
- Indoor and outdoor pool
- Fitness center
- Business center
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Daily housekeeping
- Front desk safe
- Laundry service
- Conference space
- Free newspapers in the lobby
What's around
- In Castleton
- Castleton Square (1.2 mi / 1.9 km)
- Climb Time Indy (1.5 mi / 2.4 km)
- Fishers Banquet Center (2.5 mi / 4 km)
- Ritchey Woods Nature Preserve (2.9 mi / 4.7 km)
- Fashion Mall at Keystone (3.8 mi / 6.2 km)
We stay in Drury Inn whenever we travel and they exist in our track. Never disappointed.…
Not a bad hotel, but not sure if it was worth the price.
Enter dates to check prices
Hotel Info: 866-266-9798from $156 CAD
- Deluxe Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave
- Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (2 Rooms,Sofabed)
- Deluxe Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (Jetted Tub)
- Deluxe Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (Oversized Room)
- Deluxe Room, 1 King Bed, Accessible, Non Smoking (Refrigerator & Microwave)
- Deluxe Room, 1 King Bed, Non Smoking, Refrigerator & Microwave
- Suite, 1 King Bed with Sofabed, Non Smoking, Refrigerator & Microwave (2 Rooms)
Also popular with travellers from Canada
At a glance
Key facts
Hotel size
- This hotel has 210 rooms
- This hotel is arranged over 8 floors
- Check-in time starts at 3 PM
- Check-out time is 11 AM
- Express check-out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Pets allowed (dogs and cats only) *
- Restrictions apply *
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
- Accessible parking
Other information
- Smoke-free property
Nearby Three Star Indianapolis hotels
In the hotel
- Free hot/cold buffet breakfast daily
- Free reception
- Coffee/tea in the lobby
- Indoor pool
- Outdoor pool
- Fitness facilities
- Spa tub
- Business center
- Conference space
- One meeting room
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Elevator/lift
- Safe-deposit box at front desk
- Designated smoking areas
- Television in lobby
- Disabled parking
- Accessible path of travel
- Accessible bathroom
- In-room accessibility
In the room
- Climate control
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
- Cable TV channels
- Desk
- Free WiFi
- Free long-distance calls
- Refrigerator
- Microwave
- Daily housekeeping
Top Indianapolis hotels
Recently reviewed hotels in Indianapolis
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Nearby hotels
Drury Inn & Suites Indianapolis Northeast, Indianapolis's small print
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Optional extras
Rollaway beds are available for USD $10 per night
Pets are allowed for an extra charge of USD 15 per accommodation, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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Top Definition
Another name for the town Burlington in Vermont because of all the weed that gets smoked there.
"Let go to burlington, i mean burnlington, and smoke so much weed and pass out on pine st.
by 9999999999999 November 02, 2008
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Click any word in a definition or example to find the entry for that word
used for telling someone that you are ashamed or unhappy about something that you have done that has hurt or upset them
spoken formalused for saying you are sorry because you have made a slight mistake, for example because you have stood on someone's foot. 'Sorry' is a less formal way of saying this
used for showing you are sorry for interrupting someone
used when you want to say or do something that may offend the person you are talking to
used for politely telling someone something that might make them sad, disappointed, or angry, for example when you cannot do what they want or do not agree with them
used for saying that you are not responsible for something that has happened, especially when you are sorry about it
in an online conversation, repeatedly asking a person questions which suggest that you are interested in what they are talking about, but are actually intended to annoy themBuzzWord Article
Open Dictionary
an electric skateboardadd a word
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A must for anyone with an interest in the changing face of language. The Macmillan Dictionary blog explores English as it is spoken around the world today.global English and language change from our blog


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Fiesta Cake Knife
Sorry, the item isout of stock
Celebrate in style with this Fiesta cake knife. Its colored handle coordinates perfectly with your favorite Fiesta collection. No matter the occasion, you'll love having this Fiesta cake knife on hand.
- Durable stainless steel construction resists corrosion and rust.
- Details:
- Hand wash
Our hassle-free return policy means worry-free shopping.
- Return any item, anytime, for any reason.
- No receipt? No problem. We'll take care of you.
- Yes, you can return it in store (even if you bought it online!).
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A Qoute to my Daughter ,
Don't be afraid to make mistakes,to stumble and fall because most of the time the greatest rewards come from doing things that scare us the most...
Maybe you'll get everything you wished for.
Maybe you'll get more than you ever have imagine.
Who knows where life could take you. The road is long and in the end the jorney is a destination.
To my sweet loving little lady whom is becoming a woman...I love you.... I know this Layout isnt much Just really did a simple one...Im just really proud of my self gettin back in the grove of things....Thanks for stopping by...hugs Dawna


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Doctors, the difference between the winners and the losers?
One More Step!
Dr. John Donofrio B.S., D.C., DABCN, FACFN s an established and well respected doctor, educator and consultant. He has identified, established and implemented the most appropriate, effective and least invasive protocols for restoring and and sustaining health and balance within patients. He has ongoing clinical research supporting the development of his methods and his seminar series for health professionals around the world on natural health care protocols .
Dr. Donofrio has been an active health professional for almost 30 years. He has distinguished himself in the areas of natural health care, Chiropractic neurology, international lecturing, teaching and music. He is the President of the American Chiropractic neurology Board.
Dr. Donofrio has a successful practice in Pennsylvania where he and his team utilize Chiropractic neurology, nutrition, Erchonia low level cold light laser therapy and detoxification programs to help people heal and grow. Over 90% of his patient base travel from around the world to utilize his treatment plans.
Y-File Locations:
Marietta, GA
May 30-31, 2015
Life University Room C- 1
1269 - Barclay Circle
Marietta GA 30060
tel: 770-426 -2753
Daytona Beach, FL
July 18-19, 2015
S.F. Bay Area (Union City)
July 25-26, 2015
12 Hours of CE Credit
Crowne Plaza
32083 Alvarado-Niles Rd
Union City, CA 94587


text:
Comfort Inn
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Continental Breakfast
- Drycleaning onsite
- Non-smoking hotel
- Refrigerator in room
- Wireless internet connection in room (free)
- High-speed internet in room
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TripAdvisor Reviews Comfort Inn Parry Sound
Travel Blogs from Parry Sound
How long to Grandma's House?
... lost another hour yesterday, so we are a tad behind. On the road by 10:38am. Thought about backing into the noisy tent a couple of times... Stopped for a quick bite of lunch at the exit to The Elliot lake. It used to be a great place to stop but now it is so run down. The trees and shrubs are either dying or growing across the entranceway, making it harder than usual to manoeuvre our big rig into and out of the spot. There was once a sort of demonstration swamp ...
Taking our Friends Sailing
... turned out perfectly and the sunset was gorgeous. It was getting dark by the time we got back to Kilcoursie Bay and anchored. After quick goodbyes, James ferried each Brenda, Rob and Emma back to the beach - three quick trips!
We certainly are very good at stand up paddling, with all the practice we get on our boat.
We settled in for the night, playing a couple of rounds on Battleship, the boys beating us both ...
Back at Killbear
... well with Jake and Lucas played with Bailey quite a lot. Lucas and Bailey caught minnows and later built a very creative frog habitat. In fact, Lucas is now talking about getting a pet frog. The funny thing was that later on when James went back to the boat, there was a little frog sitting on the deck! Maybe he wants to come home with us!
All of the kids loved playing on the paddle board. At one point, we realized Marcos and Jake were heading out to our ...
... so we decided to head in to Kilcoursie Bay. We were due here tomorrow anyway to see our friends and the idea of a hot shower was very inviting, especially to me!
We had a late dinner then all went ashore for showers and a run around on the beach. At this point it was getting late, but we still stayed up to play a round of Battleship. The boys were a team and delighted in beating their ...
More Relaxing
We decided to stay put today and just hang out here at Franklin. The forecast was for possible thunderstorms which never materialized. We had a few brief showers but that was it. Other than that it was a gorgeous day. A bit overcast for most of the day which we enjoyed after being in strong sunshine for several days. We are all looking very tanned with a little pink in some spots! At about 4:00 the ...


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Ratings based on 1,068 Verified Reviews
They paid and stayed. We double-checked.
4.7 Room cleanliness
4.7 Service & staff
4.6 Room comfort
4.4 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Everyoneby A verified traveler from CO
large room with separate seating areaPosted Oct 5, 2015
Location: Away from the bustle of Union Square; easier to get transportation in and out of the hotel without being stuck in traffic.
Great location; easy access to all major attractions. Staff was great!
for Everyoneby A verified traveler from London
Lovely hotel centrally located.Posted Sep 28, 2015
The service was excellent, the staff were very helpful when I asked to check in early and they gave me a lovely suite. It is well located about 10 mins walk tk Union square on hob hill which is a lovely area. I would definitely go back there.
for Everyoneby A verified traveler
Posted Sep 26, 2015
Clean rooms. Nice views. Across from a park and a nice place to relax.
for Everyoneby A verified traveler from Steyning, uk
Well situated in the centre of everything.Posted Sep 20, 2015
Pros: The room/suite.
Cons: Disappointingly slow check in, not needed at 10pm after a day's travelling. Why are room safes always put on the floor or bottom of a wardrobe?
Location: Very central.
Magnificent room but should be for the price. On Nob Hill close to Union Square and a short trolley ride from Fisherman's Wharf.
for Everyoneby A verified traveler
odd mixPosted Sep 9, 2015
Pros: Big room.
Cons: Finish repairing the place.
Location: Opposite Grace Cathedral, close to Union Square and pretty close to N. Beach / Coit Tower, but with lots of hills in the way (it is SF after all).
The restoration of this old hotel is not complete. The amenities were top notch and comfortable, but plaster is peeling off the bathroom walls and the exterior stucco is similarly damaged. You'll get good exercise hiking down the hill to Market / Union Square (and back up).
for Everyoneby A verified traveler from St. Louis, MO
Nob Hill treasurePosted Sep 9, 2015
The hotel is well appointed and comfortable. The bathroom is a bit on the small side, but the room itself was large (we were upgraded to an executive room). And the bathtub was amazing to soak in after walking all over the city! The staff was helpful and friendly, and the views were tremendous!
for Everyoneby A verified traveler from London
Nice hotel and spaPosted Sep 9, 2015
This is a nice hotel, the spa and the resturant are lovely. Only downside was that another guest and I were told off for swimming in the infinity pool (which we were told is only for relaxing NOT for swimming, even if it's just a general breast stroke and no one else is using the pool!).
by A verified traveler from toronto
Great location; customer service needs improvementPosted Sep 9, 2015
Pros: Location and room sizes
Cons: Front desk customer service skills It's 2015-FREE WIFI
Location: Safe and convenient location
This hotel is located in a great and safe location in San Francisco. The hotel rooms are large and comfortable and street level noise is at a minimum if placed in a room on a higher level. We were on the 12th floor and street noise was barely audible. Check in was very easy and we were given a room with a beautiful view since we were celebrating our anniversary. However because the front desk made an error when taking our credit card for any hotel incidentals, there solution instead of sending us a message or letter to our room (the previous 3nights) was to lock us out on our last night in the hotel. The staff working at night did not even bother to apologize for their error and were basically smirking at our customer service complaints. Normally we do not let these kind of situations bother us when on holiday, however my husband and I felt so embarrassed and insulted in the way we were treated. This incident and the way it was handled should not have occurred at a hotel of this stature, especially when the room had already been prepaid at $550/night. I guess the hotel was worried we were not going to pay their $15US/ day for wifi, which is absolutely ridiculous to charge for in 2015. What started off as a great experience ended off in major disappointment, especially in the way our situation was handled.
for Couplesby A verified traveler
Cannot thank them enough!Posted Sep 5, 2015
Superior, friendly service. Beautiful rooms. My wife and I and our parents stayed here the night before our wedding day. We all felt very well looked after. Be sure to have dinner and drinks at The Big Four restaurant on site. Very best bet atop scenic Nob Hill.
for Everyoneby A verified traveler from New York, NY
Nice boutique hotel at quiet and convenient areaPosted Aug 25, 2015
Pros: Small but well maintained, enriched hotel amenity.
Cons: Coffee or tea lounge would be nice,
Location: Approx 2 to 3 blocks to the small grocery store, wine shop, caffe, and drugstore.
Stayed this hotel by choosing mystery hotel to try something new that I would never book by myself, as I I tend to choose hotel chains with steated quality such as Starwood, Hilton, or Marriott. I enjoyed my stay at this stylishly renovated boutique hotel in terms of hotel amenity and service offered, as well as warm and welcoming hotel staff member. It was relaxing and seamless stay and I would probably come back without a discount rates. For the hotel amenity: Access to the spa that has sun deck with view and dining service was great. Drinks, fruits, magazines are available, and facility is well maintained. Turn down service was appreciated. Room amenity was very enriched, I found to be much better than the big hotel chains. Only thing that was not pleasant about this hotel is that I had ezuma? breakouts and redness though out my body after jacuzzi and pool, which gotten worse by next morning...


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Colorectal cancer (CRC), which has become especially prevalent in developed countries, is currently the third highest cause of cancer mortality in Taiwan. Mutation of the adenomatous polyposis coli (APC) gene, a tumour suppressor, is thought to be an early event in colorectal tumourigenesis. To date, however, no large-scale screening for APC gene variants in Chinese subjects has been performed. The present study was undertaken to identify APC gene variants that are significantly associated with the occurrence of CRC in Taiwanese subjects.
In order to compare the genotype distribution of variant sites, the full-length APC genes of 74 healthy individuals and 80 CRC patients were sequenced.
Among the 154 Taiwanese subjects examined in this study, three new mutations, but no previously reported mutations, were found. One deletion at codon 460 leading to a frameshift and two missense mutations resulting in p.V1125A and p.S1126R substitutions were identified. Additionally, three high risk genotypes associated with three single nucleotide polymorphisms and one low risk genotype at codon 1822 were identified.
The findings of this case-control study are consistent with the proposal that Taiwanese subjects differ from other subjects with respect to phenotypic presentation of APC and CRC risk.
Colorectal cancer (CRC) has increased in incidence over the past two to three decades and has become especially prevalent in developed countries. For example, CRC is currently the second most common form of cancer and the third leading cause of cancer mortality in the United States [1]. In Taiwan, CRC has become the fourth most common form of cancer and the third leading cause of death due to cancer. Approximately 10% of CRCs are attributable to genetic alterations whereas 90% occur sporadically [2].
Familial adenomatous polyposis (FAP), a disease inherited as an autosomal dominant, is characterized by the development of multiple colorectal polyps and possesses the potential to progress to CRC. FAP is now recognized to be caused by a functional mutation in the adenomatous polyposis coli (APC) gene [3,4]. The APC gene is located at 5q21-q22, contains 15 exons, has a corresponding mRNA of approximately 10 kb, and encodes a large protein with multiple functional domains. The gene product has been linked with several important processes including cell adhesion, maintenance of cytoskeletal integrity and chromosomal stability, and regulation of the cell cycle [5]. Previous findings are consistent with the proposals that the APC gene functions as a tumour suppressor and that somatic mutations in the APC gene predispose humans to development of FAP. The loss of APC function is currently thought to represent an event critical to colorectal tumourigenesis [6].
Although CRC attributable to mutations of the APC gene that lead to development of FAP represents less than 1% of all CRCs, APC germline mutations have close to 100% penetrance [7]. Exon 15 of the APC gene encompasses 75% of the gene coding sequence and is the most common mutation site. Over 98% of mutations in this region are either nonsense or frameshift mutations. The codons 1061 and 1309 are the most common germline mutation sites, and mutations at either site often result in a frameshift [8,9]. In addition, two missense germline mutations of APC are frequently reported. The first is the p.I1307K variant which is found in Ashkenazi Jews and is associated with a several-fold increased risk for development of multiple adenomas and CRC. The second is p.E1317Q, the mutation site of which lies between the first and second 20-amino acid β-catenin binding sites. This mutation has been proposed to suppress the APC/β-catenin pathway, thereby predisposing to the development of adenomas [10-12].
Somatic mutations in the APC gene are found in over 85% of sporadic colorectal adenomas and carcinomas [13]. More than 60% of all such mutations are found within the sequence between codons 1286 and 1513 and termed the mutation cluster region (MCR) [14]. Two hotspots for somatic mutations are found at codons 1286 and 1450; mutations at these sites often result in stop codons [8,9]. Mutations in regions of the MCR encoding the 20-amino acid β-catenin binding sites may result in functional defects in the APC protein [12].
To improve current understanding of the genetics and biological functions of APC, additional screening of the gene for single nucleotide polymorphisms (SNPs) or missense mutations is needed. Furthermore, recognition of such mutations is essential in determining the inherited risks for CRC. APC gene variants may present as population-specific. To date, however, no large-scale screening for APC gene variants in Chinese subjects has been conducted. The present case-control study was performed to characterize SNP mutations of the APC gene in the Taiwanese population and to identify the variants that are significantly associated with the occurrence of CRC.
Subjects samples
Health examinations were performed for 74 individuals at the Hualien Tzu Chi Medical Center and for 80 colorectal cancer patients at the Tri-Service General Hospital. All subjects were screened for colorectal tumors by colonscopy and none of them has the family history of CRC. Written informed consent was obtained from all subjects, and the study protocol was approved by The Protection of Human Subjects Institutional Review Board Tzu-Chi University and Hospital, IRB093-54.
The study group was comprised of 80 colorectal cancer patients and 74 healthy adults. The patient group consisted of 40 (50%) males of 63.6 ± 12.5 years of age (mean ± SD; range, 35–95 years) and 40 (50%) females of 59.2 ± 11.0 years of age (mean ± SD; range, 37–80 years). The mean age ± SD for all patients was 61.5 ± 12.0 years (range, 35–95 years). The health examination group consisted of 34 (45.3%) males of 55.8 ± 11.5 years of age (mean ± SD; range, 32–84 years) and 41 (54.7%) females of 53.0 ± 8.7 years of age (mean ± SD; range, 39–72 years). The mean age ± SD for all healthy adults was 54.3 ± 10.1 years (range, 32–84 years). In the patient group, there were 16 (20%) subjects with proximal tumors, 26 (32.5%) subjects with distal tumors, 38 (47.5%) subjects with rectal tumors, and there were 8 (10%) subjects with colorectal tumors in Duke's stage A, 24 (30%) in Duke's stage B, 38 (47.5%) in Duke's stage C and 10 (12.5%) in Duke's stage D.
DNA extraction
Genomic DNA was extracted from 10 ml of whole blood through use of the Puregene Genomic DNA Purification Kit (Gentra Systems, Inc., Minneapolis, MN, USA). The extracted DNA was quantified with a DU 640 spectrophotometer (Beckman Instruments, Inc., Fullerton, CA, USA).
Gene amplification and DHPLC
The coding region of the APC gene was divided into 28 segments, each of which was amplified separately using the polymerase chain reaction (PCR). The primer pairs used in this study were designed for both PCR and denaturing high performance liquid chromatography (DHPLC; Transgenomic, Inc., Omaha, NE, USA) as previously described [15]. All samples were amplified in 50-μl of a reaction mixture containing 50 ng genomic DNA, 10 mM Tris-HCl, 50 mM KCl, 2.5 mM MgCl2, 0.2 mM of each dNTP, 200 mM of each primer, and 0.15 U AmpliTaq Gold DNA polymerase (Applied Biosystems; Roche Molecular Systems, Inc., Branchburg, NJ, USA). The thermal cycling profile was composed of an initial denaturation step at 95°C for 10 min, 35 cycles of 30 sec of denaturation at 95°C, 30 sec of annealing at 55°C, and 1 min of extension at 72°C, with a final 10-min extension step at 72°C. DNA samples amplified from the same regions of APC genes were subjected to DHPLC and compared. When observed peaks differed in sharpness or appeared with more than 0.08 sec of difference from the main peak, potentially different DNA sequences were suspected. Such samples were therefore subjected to sequencing.
DNA sequencing
Sequencing reactions were performed with the BigDye Terminator v3.1 Cycle Sequencing Kit (Applied Biosystems, Foster City, CA, USA). Each sequencing reaction was amplified in a 10-μl reaction mixture containing 10–30 ng amplified DNA. The thermal cycling profile consisted of an initial denaturation step at 95°C for 10 sec, 25 cycles of 10 sec of denaturation at 95°C, 5 sec of annealing at 50°C, and 1 min of extension at 60°C. Primers used for direct sequencing reactions were identical to those used in the amplification reactions. Nucleotide sequences of both strands were determined with an ABI Prism 3100 Genetic Analyzer (Applied Biosystems, Foster City, CA, USA) equipped with a long-read sequencing capillary and a POP-4 sequencing polymer.
Data analysis
The sequence data collected from the ABI 3100 Genetic Analyzer were analyzed by software programs from Applied Biosystems. The analyzed sequence data were aligned through the use of BioEdit 7.0.5 software [16]. The Chi-square tests for Hardy-Weinberg equilibrium, the Chi-square and Fisher's exact tests for differences between the patient and health examination groups, and logistic regression analyses for odds ratios (without adjusting for other variables) were processed by SAS 9.1.
When the coding regions of APC genes of all 154 subjects enrolled in the study were sequenced, 12 SNPs and 1 deletion mutation were identified (Table 1). Of these variants, 8 SNPs were located within exon 15, 2 SNPs within exon 11, 1 SNP within exon 9, 1 SNP within exon 13, and 1 deletion within exon 10. Of the 12 SNPs, 9 are silent substitutions and 3 are responsible for the amino acid changes p.V1125A, p.S1126R and p.D1822V. Ten SNPs were identified in the health examination group and 2 of these SNPs, g.1488A>T and g.3378C>G, were not found in the patient group. Ten SNPs and 1 deletion mutation were found in the patient group and 3 of these variants, g.1050T>G, g.1378delG and g.4725A>G, were not found in the health examination group (Table 1).
Table 1. Genotype distributions for the health examination and patient groups.
The single base pair deletion, g.1378delG, which is located in exon 10, was found only in one individual in the patient group. This subject presented with a heterozygous genotype, confirmed by repeated forward and reverse sequencing. Prevalence of this mutation, which is reported here for the first time, was not significantly different between the patient and health examination groups.
Of the 3 observed missense substitutions, p.V1125A and p.S1126R represent variants not previously reported. p.V1125A was identified in three subjects in the patient group and in one subject in the health examination group, but p.S1126R was found only in the health examination group. However, the prevalence of these variants did not differ significantly between the patient and health examination groups. The characteristics of the subjects in the patient group with g.1378delG deletion or g.3374T>C (p.V1125A) are listed in Table 2. Prevalence of the p.D1822V variant, which has been observed previously [17-19], was significantly different between the patient and health examination groups. When this variant was analyzed further by determination of the odds ratio, a low risk for CRC was observed for subjects displaying the AT genotype (Table 3).
Table 2. The characteristics of the patients with 1378delG or 3374T>C.
Table 3. The ORs for CRC of APC genotypes at g.1458T>C, g.4479G>A, g.5268T>G and g.5465A>T.
Of the 12 SNPs identified, only g.1458T>C and observed within the patient group displayed significant deviation from Hardy-Weinberg equilibrium (p = 0.002). To ascertain whether differences in the genotype distribution existed between the health examination group and patient group at these SNP sites, the Chi-square test and the Fisher's Exact test were performed. Significant differences were observed at g.1458T>C (p = 0.0012), g.4479G>A, (p = 0.0057), g.5268T>G (p = 0.0023). Analysis of the odds ratio for each genotype at these three sites revealed that g.1458T>C and g.4479G>A were significant and g.5268T>G was close to significant associated with a higher risk genotype (Table 3).
In this case-control study involving the screening of 74 healthy Taiwanese adults and 80 Taiwanese CRC patients for germline variants throughout the entire coding region of the APC gene, three new mutations were identified. No mutations reported in previous studies, including those at codons 1061 and 1309 which are considered the most common mutation sites, were identified. The absence in these Taiwanese subjects of the Caucasian-specific mutations p.E1317Q and p.I1307K that are known to cause missense changes is in accord with the findings of Guo et al. [20]. Additionally, Asian-specific variants such as the odd mutations reported in a Japanese study [21] were not displayed by any of the Taiwanese subjects in the present study. These observations are consistent with the proposals that the different presentations of the APC gene in these Taiwanese subjects are due to population differences and that the new mutations found in this study represent Taiwanese-specific hotspot mutations.
The three new mutations identified in the present study include a one base pair deletion and two missense substitutions. The one base pair deletion occurs at codon 460 of exon 10 and will cause a frameshift resulting in expression of a truncated protein. The two missense substitutions, p.V1125A and p.S1126R, occur in close proximity to the first 15-amino acid β-catenin binding repeat (amino acids 1136–1151) located at the center of the β-catenin down-regulation domain. Such substitutions may result in disruption of the putative cell signaling function of the APC protein; however, this needs to be demonstrated experimentally. It should be noted that all three mutations presented with low frequency in subject population of the present study and that the p.S1126R mutation was observed only in the health examination group. The sites at which these mutations occur, therefore, may not represent hotspots commonly associated with CRC. Nevertheless, the presence of these mutations may result in development of CRC. Long-term monitoring of persons who present with these mutations is therefore considered essential.
The frequency distribution of the 13 variants identified in the present study differed significantly between the health examination group and patient group at g.1458T>C, g.4479G>A, g.5268T>G and g.5465A>T (Table 1, p < 0.05 by the Chi-square test or Fisher's Exact test). Further analysis by logistic regression indicated that genotypes at g.1458T>C, g.4479G>A and g.5268T>G had high odds ratios for CRC (Table 3). These genotypes may therefore serve as markers predicting the development of CRC. The polymorphism p.D1822V, which was observed in the present study, is located in close proximity to the fifth APC cysteine-rich region β-catenin binding repeat (amino acids 1840–1866). p.D1822V is a missense variant previously shown to be a common polymorphism unrelated to the risk of developing CRC or colorectal adenoma [18,19]. However, two previous studies of CRC demonstrated significant gene-environment interactions between the p.D1822V polymorphism and consumption of a low-fat diet and postmenopausal hormone use [19,22]. Although no TT homozygotes for this site were identified in the present study, AT heterozygotes for this site were identified who had a low odds ratio for CRC (Table 3). The presence of a T allele at this site may therefore serve to protect against development of CRC.
Certain SNPs of APC genes were previously reported to be differentially distributed among different populations. Of the 10 SNPs identified in the present study the only SNP with a significantly different allele distribution, as determined by comparison with the East Asian population through use of the NCBI SNP databank (p <0.05, Chi-square test), was g.4479G>A. Further analysis revealed that an AA genotype for this SNP is associated with a higher risk for CRC. This observation implicates this genotype as a likely marker for CRC in the Taiwanese population. The other two SNPs, g.1458T>C and g.5268T>G, with higher risk genotypes for CRC were not found to have an allelic distribution different from other East Asian populations as determined through use of the NCBI SNP databank. These SNPs may therefore serve as markers for CRC specific to East Asian populations.
Investigations of the relationships existing between SNPs or germline mutations in the APC gene and occurrence of CRC should enable more accurate predictions of CRC. Furthermore, extensive screening of FAP patients should lead to a better understanding of the importance of events underlying development of CRC. Future studies of various high-risk APC gene mutations may also lead to improvements in therapy and, therefore, to increased survival of CRC patients.
Among the APC genes of the 154 Taiwanese subjects examined in this case-control study three new mutations, but no previously reported mutations, were identified. Taiwanese subjects therefore appear to differ from other subjects with respect to the genotypic presentation of APC. Three high risk genotypes at 3 SNPs and one low risk genotype at codon 1822 were identified in this study. The latter was reported previously to have no association with CRC.
CRC, colorectal cancer; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; DHPLC, denaturing high performance liquid chromatography
Competing interests
The author(s) declare that they have no competing interests.
Authors' contributions
SPC carried out the acquisition of data, data analysis, drafted and wrote the manuscript. STT, YLH, YLC, YCC and CCW participated in the acquisition of data, sequence and wrote the manuscript. SZL, HJH, SWJ conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
This study was supported by grants from the National Science Council NSC94-2320-B-303-001, Taipei, Taiwan.
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Pre-publication history
The pre-publication history for this paper can be accessed here:


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(Video Link)If you ever poke around the Neatoshop, then you probably already know that we're simply mad about Minions. We've seen Cookie Monster, Sponge Bob and even Baymax cosplay as our favorite yellow followers, but t...http://www.neatorama.com/2015/06/28/Goats-Dressed-Like-Minions-Are-The-Best-Minions/
Many things seem like a good idea as long as you d... ...ply precious and watching one climb into a cup is cute as all heck -but that doesn't mean you want to dr... ...t doesn't bother you and you simply must have the cute , they can be yours for a very reasonable $2.50 ea...http://www.neatorama.com/2015/05/27/Cute-or-Cringe-Worthy-Little-Hamsters-for-Your-Cups/
If there's one thing everyone on Instagram seems t... ...s this great Oddee article highlighting 14 of the cutest cats, dogs and other critters on the site.Granted... ...-like Lil Bub and Sam, but there's a whole lot of cuteness on this list that's still new to us.http://www.neatorama.com/2015/05/18/Can-You-Even-Handle-the-Cutest-Critters-of-Instagram/
(Video Link)As I've previously stated, we at Neato... ...ke much to convince him to symbolically adopt the cute little one.Video via Pets Ladyhttp://www.neatorama.com/2015/05/12/Were-Not-The-Only-Ones-Batty-For-Bats/
Sometimes working online leads you to run across some strange things on the net. Today though, it led me to a bright and wonderful path where I happened to run across a literal dog and pony show. I don't know much more a...http://www.neatorama.com/2015/04/30/Now-Thats-What-I-Call-A-Dog-and-Pony-Show/
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(Video Link)We've seen plenty of dogs that love to be vacuumed, but Scooter proves that pooches aren't the only ones -birds also love the experience. This dirty birdie isn't shy about sharing his passion for the suction...http://www.neatorama.com/2015/04/22/Scooter-Loves-the-Vacuum/


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Novgorod by V. Gippenreiter, E. Gordienko, and S. Yamshchikov. 1976 hardcover published y Planeta Publishers, Moscow. Text in Russian and English.
More editions of Novgorod (Russian and English Edition):
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- Tags: Bikini, Gravure, Idol, Image Gallery, Mizugi, Oppai, Oshiri, Voluptuous
Comment on Alisa: "Plump Idols Are The Sexiest!" by yuriphoria:
Recent comments by yuriphoria:
- Hidan no Aria AA Brimming With Action:
OK I agree that the random Anon always complaining about the male MC in all shows is annoying. *But*, when the entire point of a series is the cute girls, it does makes sense to get rid of the dick doesn't it?
- Japan Real Estate: "Own A Home That's Also A Mech!":
Even if it were to work. Do you realize they are basically using the people's homes as armor? This has to be regarded as a war crime.
- Unlimited Blade Works BD Box Cuts Deep:
It's Unlimited Blade Works. You don't buy the BD for nipples. You buy it to honor the creators.
- Top 10 Games Owed Anime Adaptations:
Agreed on Chrno, but Zelda already had an adaptation and it showed it didn't work.
- Yuru Yuri San Hai Still Gloriously Yuri:
#17 "Don't mess up with my ship!"


text: [ Tesla Unveils Batteries to Power Your Home with Solar Electricity By Associated Press May 1, 2015 FOSTER CITY, Calif. (AP) — Electric car maker Tesla Motors wants to park its battery technology in homes and businesses across the U.S... Read More|Comment Category: Human Interest, Lifestyle, Technology Tags: batteries, electricity, Elon Musk, home power, Powerwall, solar power, tesla, tesla electric car, tesla motors Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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The iconic doll debuts four exclusive beauty looks, courtesy of Pat McGrath.
10 Common Hair Myths Debunked
Step one: London-based hairstylist Adam Reed recommends starting by brushing hair back tight and low, securing with a bungee elastic.
Tip: For an ultratight pony, tilt back your head and look up at the ceiling while you fasten hair.
Step two: Tame flyaways with smoothing cream. To prevent any damage from heat styling, prep the pony with thermal-protecting spray.
Straight Talk: 11 Favorites for Getting Smooth Hair


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Wrestling: Mr Fuji
Harry Fujiwara (b. 1935) is a retired Japanese-American Professional Wrestler, manager and trainer from Honolulu, Hawai'i who is best known for his work in WWE as Mr. Fuji. He debuted in 1965 in Hawaii and would go on to compete for a variety of territories. He switched from wrestling to managing in 1985 and would continue in that role until he retired in 1996. Among his in-ring achievements, he was a 5x WWE World Tag Team Champion, a 4x NWA PNW Tag Team Champion, and a 1x IWA (Australia) World Tag Team Champion. As a manager, he led Demolition to their first WWE World Tag Team Title reign and Yokozuna to his two WWE World Heavyweight Title reigns.As usual, you can find the basics at The Other Wiki.
"The Devious Tropes":
- Arch-Enemy: Ricky Steamboat, The Undertaker
- Awesome Moment of Crowning: Inducted into the WWE Hall of Fame in 2007.
- Badass in a Nice Suit: Until he switched to a robe when he managed Yokozuna.
- Badass Mustache
- Bald of Evil: In the 1990s. Bald of Awesome when he and Yokozuna turned face after Jim Cornette picked Vader over Yoko.
- Bash Brothers: With Toru Tanaka, as they teamed and held gold in many promotions.
- Beard of Evil
- Cane Fu: His Weapon of Choice.
- Facial Markings: When he managed Demolition.
- Finishing Move: Cobra Clutch
- Foreign Wrestling Heel: Billed from Osaka, Japan.
- Giftedly Bad: Hit it, Mr. Fuji!
- A Handful for an Eye: Salt in the eyes was a favorite trick.
- Hard Head
- Large Ham: In Real Life. Probably one of the most prolific and elaborate ribbers in the business.
- The Master: Referred to at times during the 1990s, by the Berzerker among others, as "Master Fuji."
- Nice Hat: A Dastardly Dapper Derby.
- Power Stable: (in Australia): Big Bad John's Army
- Red Baron: "The Devious One"
- Stout Strength
- Villain Team-Up: With Cornette.


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Don't let your friends have all the fun this weekend. Just think of the great stories you'll have to tell after attending any of these events.
Give some love to the great outdoors. Saturday, June 7 is National Trails Day and Tyler Arboretum in Media, PA is encouraging volunteers to give some maintenance to the trail, starting at 8 a.m. Following there will be a number of hikes, demonstrations and educational displays available as well as food.
Since Wednesday, the Odunde Festival, a huge and festive African American celebration, extending until Sunday, June 8 features special events this weekend. On Saturday, June 7 at 9 a.m., record numbers of exercisers will shake it at Chew Playground at 19th and Washington Avenue for a one-hour Zumba class. From there, get to West Philly at the Please Touch Museum for an all-day African Family Day bash from 9 a.m. to 5 p.m.
The shopping extravaganza, Punk Rock Flea Market, presented by R5 Productions, returns to the Punk Rock Flea Market Dome on 9th Street for two days, Saturday, June 7 and Sunday, June 8. From 10 a.m. to 5 p.m. both days, shoppers will have a chance to sort through a selection of vinyl records, clothes, art, bicycles, furniture and more from the over 500 vendors.


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tampa bay
Dick Vitale Predicts Lightning Wins Series vs. Rangers In Six [AUDIO]
Yanks in First After Beating Tampa Bay
Report: Maple Hill Grad to Start Opening Day For AA Team
Long Ball Dooms Yanks in Loss to Rays
Derek Jeter's Press Conference [PHOTO GALLERY]
Derek Jeter's press conference on Thursday was a memorable one and officially announced the beginning of the final season for No.2.
Jeter Reminded Us Why He's Jeter At Press Conference
On Wednesday, Derek Jeter spoke for the first time since announcing that this would be his last season, via Facebook.
Audio: Jeter's opening statement -
For anyone who has forgotten or doesn't understand why 'The Captain' has gotten so much attention by the fans and media since his announcement, we were all reminded quickly...


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May 12, 2013
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