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Pharmacology (PHARMACOLOGY)
Journal description
This journal communicates research in basic and clinical pharmacology and related fields. It covers biochemical pharmacology, molecular pharmacology, immunopharmacology, drug metabolism, pharmacogenetics, analytical toxicology, neuropsychopharmacology, pharmacokinetics and clinical pharmacology. In addition to original papers and short communications of investigative findings and pharmacological profiles the journal contains reviews, comments and perspective notes. ëPharmacologyí is an international forum to present and discuss current perspectives in drug research.
Current impact factor: 1.67
Impact Factor Rankings
|2015 Impact Factor
|Available summer 2016
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|1992 Impact Factor
Impact factor over time
Additional details
|5-year impact
|Cited half-life
|Immediacy index
|Article influence
|Pharmacology website
|Other titles
|Pharmacology (Online)
|Material type
|Document, Periodical, Internet resource
|Document type
|Internet Resource, Computer File, Journal / Magazine / Newspaper
Publisher details
- Pre-print
- Author can archive a pre-print version
- Post-print
- Author can archive a post-print version
- Conditions
- On author's server or institutional server
- Server must be non-commercial
- Publisher's version/PDF cannot be used
- Publisher copyright and source must be acknowledged
- Must link to publisher version
- Classification green
Publications in this journal
Article: Renoprotective effects of fenofibrate via modulation of LKB1-AMPK mRNA expression in a rat model of diabetic nephropathy.[Show abstract] [Hide abstract]
ABSTRACT: This study was conducted to investigate whether the renoprotective effects of fenofibrate are mediated via attenuation of endothelial dysfunction and modulating the mRNA expression of adenosine monophosphate -activated protein kinase (AMPK) and its downstream kinase; LKB1 in rats with diabetic nephropathy (DN). Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg kg-1). Fenofibrate (100 mg kg-1, p.o) was given to diabetic rats daily for twelve weeks. Treatment with fenofibrate significantly improved the renal function as revealed by the significant reductions in the urinary albumin excretion, serum levels of creatinine and urea, in addition to the significant increase in creatinine clearance compared with diabetic control group. Hyperglycemia-induced oxidative damage was ameliorated by treatment with fenofibrate as indicated by the significantly increased levels of glutathione and catalase together with the significant decrease of lipid peroxidation. Administration of fenofibrate caused significant increases in renal NO production and mRNA expression of eNOS, AMPK and LKB1 reflecting improvement of endothelial function. Our results give further insights into the mechanisms underlying the protective role of fenofibrate in DN via modulation of AMPK, LKB1 and eNOS mRNA expression.Pharmacology 02/2015;
Article: Altered Inhibitory Function of the E-Type Prostanoid Receptor 4 in Eosinophils and Monocytes from Aspirin-Intolerant Patients[Show abstract] [Hide abstract]
ABSTRACT: Prostaglandin (PG) E2 has been implicated in the pathogenesis of aspirin-exacerbated respiratory disease (AERD). E-type prostanoid (EP) receptor 4 is known to confer inhibitory signals to eosinophils and monocytes, amongst others. In this study, we investigated whether the responsiveness of eosinophils and monocytes to PGE2 and EP4 receptor activation is altered in AERD patients. While the expression of the EP4 receptor in eosinophils was unaltered in AERD patients, inhibition of eosinophil chemotaxis by PGE2 or the EP4 agonist CAY10598 was less pronounced in AERD patients as compared to healthy control subjects. In monocytes, we found no changes in basal or lipopolysaccharide (LPS)-stimulated PGE2 synthesis, but the response to EP4 receptor activation with respect to inhibition of LPS-induced tumor necrosis factor-α release was reduced in AERD patients, especially in the presence of aspirin (acetylsalicylic acid). Our data point towards a decreased sensitivity of inhibitory EP4 receptor that may play a role in AERD. © 2014 S. Karger AG, Basel.Pharmacology 12/2014; 94(5-6):280-286. DOI:10.1159/000369827
Article: The Nitric Oxide/Soluble Cyclic Guanylase/Cyclic Guanosine Monophosphate Pathway Is Involved in the Cardiovascular Effects of a Novel a 1 - and �-Adrenoceptor Antagonist[Show abstract] [Hide abstract]
ABSTRACT: The compound MH-78 ((+/-)-1-(2,6-dimethylphenoxy)-3-{4-[2-(2-methoxyphenoxy)ethyl]-piperazin-1-yl}propan-2-ol dihydrochloride) contains structural elements that are typical for α1- and β-blockers. This study aimed to investigate the hypotensive activity as well as the in vitro and in vivo cardiovascular effects of a novel α1- and β-adrenoceptor antagonist (MH-78) and compare it with carvedilol and urapidil. The procedures were performed on aortic rings of normotensive anesthetized rats. MH-78 decreased the blood pressure and heart rate after intravenous and oral administration. MH-78 possesses both α1- and β-adrenoceptor blocking activity, which was confirmed in the in vivo study. In biofunctional assays, MH-78 displayed vasorelaxant activity due to α1-adrenoceptor antagonism and calcium channel blocking properties. Moreover, in endothelium-intact aortic rings, pretreatment with Nω-nitro-L-arginine methyl ester (L-NAME) and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) reduced the MH-78-induced vasorelaxation to a level that is characteristic for MH-78 affinity to α1-adrenoceptors. Our results demonstrated that MH-78 possesses α1- and β-adrenoceptor blocking properties and induces potent hypotensive and vasorelaxant effects. Moreover, it relaxes vascular smooth muscle not only due to α1-adrenoceptor blocking activity, but also via the endothelium-dependent nitric oxide/soluble guanylyl cyclase/cyclic guanosine monophosphate signalling pathway. © 2014 S. Karger AG, Basel.Pharmacology 12/2014; 94(5-6):287-295. DOI:10.1159/000369628
Article: Association between Single Nucleotide Polymorphisms in the OPRM1 Gene and Intraoperative Remifentanil Consumption in Northern Chinese Women[Show abstract] [Hide abstract]
ABSTRACT: Background: Recent studies have suggested that some single nucleotide polymorphisms (SNPs) in the human µ-opioid receptor gene (OPRM1) affect the postoperative analgesic efficacy of opioids and their side effects. In this study, we assessed the association between SNPs in the OPRM1 gene and intraoperative remifentanil consumption as well as perioperative side effects during gynecological hysteroscopic surgery in women from Northern China. Methods: We analyzed 178 women undergoing gynecological hysteroscopic surgery. SNP genotyping was performed using the SNaPshot method. The state anxiety index (SAI) and pressure pain threshold (PPT) of all patients were assessed preoperatively. Monitored anesthesia care was maintained by the intravenous infusion of remifentanil. Intraoperative remifentanil usage and perioperative side effects were recorded. Statistical analyses were performed using SPSS software. Results: Patients carrying one or two copies of the minor allele (G allele) of rs558025 required significantly more intraoperative remifentanil than patients without the minor allele (p = 0.001, corrected p = 0.006). There were no significant associations between the six SNPs and various clinical characteristics. No significant associations between the six SNPs and PPT or SAI were found in our study. Conclusions: SNP rs558025 in the OPRM1 gene was associated with intraoperative remifentanil consumption during gynecological hysteroscopic surgery in our subjects.Pharmacology 12/2014; 94(5-6):273-279. DOI:10.1159/000368082
Article: Pioglitazone Inhibits Advanced Glycation End Product-Induced TNF-a and MMP-13 Expression via the Antagonism of NF-κB Activation in Chondrocytes[Show abstract] [Hide abstract]
ABSTRACT: Objective: Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed to investigate the possible protective effect of the PPARγ agonist pioglitazone on AGE-induced chondrocyte damage. Methods: Cultured chondrocytes were stimulated with AGEs in the presence or absence of an antibody against the receptor for AGEs (anti-RAGE), an inhibitor of NF-κB (pyrrolidine dithiocarbamate) and pioglitazone. The RNA expression levels of TNF-α, matrix metalloproteinase (MMP)-13 and PPARγ were detected by RT-PCR. The expression of nuclear p65 was determined by Western blot analysis. Results: Upregulation of TNF-α and MMP-13 as well as downregulation of PPARγ were induced by AGEs in a time- and dose-dependent manner. The maximum effect was induced by 100 μg/ml AGEs. This effect can be inhibited by anti-RAGE. Pioglitazone dose-dependently inhibited the expression of TNF-α and MMP-13 induced by AGEs, which was combined with the inhibition of nuclear p65 expression. Conclusion: The PPARγ agonist pioglitazone modulates TNF-α and MMP-13 expression in cultured rabbit chondrocytes via NF-κB signaling. It indicates that pioglitazone may have therapeutic potential in OA.Pharmacology 12/2014; 94(5-6):265-272. DOI:10.1159/000369074
Article: Chemerin Induces Insulin Resistance in Rat Cardiomyocytes in Part through the ERK1/2 Signaling Pathway[Show abstract] [Hide abstract]
ABSTRACT: Aims: Chemerin is a novel adipokine that is closely associated with cardiovascular diseases and glucose homeostasis. This study aimed to investigate the effects of chemerin on insulin resistance in rat cardiomyocytes. Methods: Rat cardiomyocytes were treated with high concentrations of glucose and tumor necrosis factor-alpha (TNF-α), and chemerin and chemokine-like receptor 1 (CMKLR1) were measured by Western blot analysis. Then, the cardiomyocytes were treated with chemerin and insulin. Glucose uptake was evaluated using a fluorescence microplate reader. Western blot analysis was used to evaluate the phosphorylation of Akt, insulin receptor substrate-1, p38 mitogen-activated protein kinase (MAPK), as well as extracellular signal-regulated kinase (ERK)1/2. Results: Chemerin and CMKLR1 were found to be expressed in rat cardiomyocytes. Pretreatment with chemerin caused decreases in glucose uptake and phosphorylation of Akt in insulin-stimulated cardiomyocytes. Furthermore, chemerin activated the phosphorylation of p38 MAPK and ERK1/2 in insulin-stimulated cardiomyocytes. Inhibition of ERK partially rescued chemerin-induced insulin resistance. Conclusion: Chemerin is a novel adipokine that induces insulin resistance in rat cardiomyocytes in part through the ERK1/2 pathway.Pharmacology 11/2014; 94(5-6):259-264. DOI:10.1159/000369171
Article: Treatment of Chronic Obstructive Pulmonary Disease by Dual Bronchodilation with Coformulation of Indacaterol/Glycopyrronium[Show abstract] [Hide abstract]
ABSTRACT: Bronchodilators are the cornerstone of the treatment of chronic obstructive pulmonary disease (COPD). In particular, the most commonly used drugs are inhaled long-acting agents, including long-acting β2-adrenergic agonists (LABAs) and long-acting muscarinic receptor antagonists (LAMAs). The combination of a LABA with a LAMA, i.e. of molecules characterized by different mechanisms of action, results in a synergistic enhancement of their clinical and functional effects. Therefore, this combined treatment can be implemented in a number of cases in which disease control is not adequately achieved by a single active agent such as a LABA or a LAMA. Several LABA/LAMA fixed-dose combinations, mainly made up of newly developed compounds, are currently in advanced phases of experimental evaluation. Within such a context, the aim of this review is to outline the pharmacological basis of dual bronchodilation as well as to discuss the results of the main trials carried out using the drug combination consisting of indacaterol and glycopyrronium, a LABA and a LAMA recently introduced in the treatment of COPD. © 2014 S. Karger AG, Basel.Pharmacology 11/2014; 94(5-6):249-258. DOI:10.1159/000368986
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ABSTRACT: Na(+)/Ca(2+) exchanger 1 (NCX1) is a plasma membrane transporter involved in regulating intracellular Ca(2+) concentrations. NCX1 is critical for Ca(2+) regulation in cardiac muscle, vascular smooth muscle and nerve fibers. However, little is known about the physiological role of NCX1 in gastrointestinal motility. To determine the role of NCX1 in gastrointestinal tissues, we examined electric field stimulation (EFS)-induced responses in the longitudinal smooth muscle of the distal colon in smooth muscle-specific NCX1 transgenic mice (Tg). Tg show that NCX1 protein was overexpressed in the distal colon at a level twofold greater than that of endogenous NCX1. We found that the amplitudes of EFS-induced relaxation that persisted during EFS were greater in Tg than in wild-type mice (WT). Under the nonadrenergic, noncholinergic condition, the EFS-induced relaxation in Tg was also greater than that in WT. Inhibition of NO synthase, CO synthase, soluble guanylate cyclase (sGC), and protein kinase G (PKG) all attenuated the enhanced relaxation in Tg, demonstrating the importance of NCX1 in NO/sGC/PKG signaling. The action of NOR-1, an NO donor, induced enhanced relaxation in Tg compared with that in WT. Unlike NOR-1, pituitary adenylate cyclase-activating peptide and vasoactive intestinal peptide induced a similar relaxation in Tg compared with that in WT. In this study, we demonstrate that NCX1 plays an important role in smooth muscle motility in the mouse distal colon. © 2014 S. Karger AG, Basel.Pharmacology 11/2014; 94(5-6):230-238. DOI:10.1159/000363246
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ABSTRACT: Background/aims: Hypercholesterolemia is a major risk factor for coronary artery disease and probiotics have been suggested as tools to manage elevated cholesterol levels. Methods: The present study investigated the ability of the biotherapeutic agent Saccharomyces boulardii (Sb-Biocodex) to reduce the hypercholesterolemia induced by a 0.1% cholesterol-enriched diet in the hamster. Results: In a first experiment, chronic oral treatment with S. boulardii at 12 × 10(10) CFU/kg (3 g/kg) twice a day was started from the beginning of the cholesterol diet and continued for 14 days ('preventive protocol'). In the second experiment, S. boulardii was given 14 days after the beginning of the cholesterol diet when hypercholesterolemia had developed and continued for an additional 14 days ('curative protocol'). In the preventive protocol, administration of the yeast significantly reduced hypercholesterolemia (14%) induced by the cholesterol-enriched diet compared to the group receiving only the cholesterol diet. In the curative protocol, S. boulardii significantly reduced hypercholesterolemia (12%) induced by the cholesterol-enriched diet, too. Moreover, the yeast significantly decreased the serum triglyceride increase by 39%. Conclusion: S. boulardii possesses anti-hypercholesterolemic properties in the hamster worthy of further evaluation in clinical studies.Pharmacology 11/2014; 94(5-6):239-244. DOI:10.1159/000365009
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ABSTRACT: The aim of this study was to evaluate the relative pharmacokinetic (PK) and pharmacodynamic (PD) properties of a single dose of ponesimod, an oral and selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, in Japanese and Caucasian healthy subjects and explore the effects of sex on PK. Subjects received a single 40-mg dose of ponesimod in a single-centre, open-label, parallel-group study design. Ten Japanese and 10 Caucasian healthy subjects (age: 22-45 years, 1:1 sex ratio) participated in the study and were matched for body weight (±10%). Ponesimod concentration in plasma was determined by liquid chromatography tandem mass spectrometry, and PK parameters were obtained by non-compartmental analysis. Total lymphocyte count served as PD marker. Adverse events (AEs), laboratory values, electrocardiography (12-lead ECG), and vital signs were assessed for safety and tolerability. Administration of ponesimod resulted in similar PK parameters between the two ethnic groups, with a 16% higher exposure [AUC0-∞ of 7,368 ng ∙ h/ml (95% CI: 6,059-8,962) vs. 6,353 ng ∙ h/ml (4,950-8,154)] and a 17% longer terminal elimination half-life [32.9 h (30.1-36.0) vs. 28.1 h (23.4-33.6)] in Japanese compared to Caucasian subjects. Exposure was slightly higher in female subjects [7,488 ng ∙ h/ml (5,983-9,371)] than in male subjects [6,252 ng ∙ h/ml (5,031-7,771)]. The maximum mean lymphocyte count decrease from baseline, observed 6 h after receiving the dose in both groups, was similar in Japanese subjects (61.8%) and Caucasians (62.5%). The maximum mean heart rate (ECG) reduction from baseline was similar, with a difference of 4.2 bpm between Caucasian and Japanese subjects, observed 2.5 h after receiving the dose in both ethnic groups. There were no clinically relevant changes in other safety variables. No serious AEs were reported during the study. This study showed that the PK and PD profile of ponesimod was similar in Japanese and Caucasian subjects. No unexpected safety findings were reported. No dose adjustment is deemed necessary for Japanese subjects compared to Caucasians. © 2014 S. Karger AG, Basel.Pharmacology 11/2014; 94(5-6):223-229. DOI:10.1159/000368837
Article: Ezetimibe-Mediated Protection of Vascular Smooth Muscle Cells from Cholesterol Accumulation through the Regulation of Lipid Metabolism-Related Gene Expression.[Show abstract] [Hide abstract]
ABSTRACT: Background: Ezetimibe is a potent inhibitor of Niemann-Pick type C1-Like 1 and has been approved for the treatment of hypercholesterolemia. Our preliminary study showed that ezetimibe promotes cholesterol efflux from vascular smooth muscle cells (VSMCs). Our aim was to investigate the cellular mechanisms underlying the ezetimibe actions. Methods and results: Rat VSMCs were converted to foam cells by incubation with cholesterol:methyl-β-cyclodextrin. The intracellular free cholesterol, total cholesterol, and the ratio of cholesteryl ester to total cholesterol were decreased after the incubation of VSMCs with different concentrations of ezetimibe (3, 10, 30, and 30 μmol/l) or treated with 30 μmol/l of ezetimibe for different time periods (6, 12, 24, and 48 h). Our results also showed that the expression of caveolin-1, liver X receptor α, and ATP-binding cassette transporter ABCA1 was enhanced, but the expression of nSREBP-1c was decreased in a concentration- and time-dependent manner. RNA interference was used to determine the roles of caveolin-1 and SREBP-1 in the lipid-lowering effect of ezetimibe. The results showed that caveolin-1 was involved in the regulation of intracellular cholesterol content, and the expression of caveolin-1 was repressed by SREBP-1. Conclusion: The present study indicates that ezetimibe protects VSMCs from cholesterol accumulation by regulating the expression of lipid metabolism-related genes.Pharmacology 11/2014; 94(5-6):214-222. DOI:10.1159/000368803
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ABSTRACT: Background: Morphine is co-administered with adjuvant drugs to treat pain, nausea, vomiting, dyspnoea and delirium in cancer patients. Aim of the Study: To investigate analgesic effects of morphine when co-administered with adjuvant drugs. Material and Methods: Two-month-old male Wistar rats received single morphine doses alone (0.45 and 0.9 mg/kg) or with midazolam (0.3 mg/kg), haloperidol (0.15 and 0.45 mg/kg), levomepromazine (0.35 mg/kg), metoclopramide (1.0 mg/kg), and hyoscine butylbromide (1.7 mg/kg) as single subcutaneous injections. Analgesia was measured by the tail-flick test after 15, 30, 45, 60, and 90 min of drug administration. In the case of significant analgesia enhancement, analgesic and sedative effects were explored in 3-, 5-, 6-, 8-, and 11-month-old rats. Results: Significant morphine (0.9 mg/kg) analgesia enhancement was observed 60 min after haloperidol (0.15 and 0.45 mg/kg) and hyoscine butylbromide co-administration. The addition of haloperidol to morphine significantly increased analgesia in 6-, 8- and 11-month-old rats while in the case of hyoscine butylbromide co-administration this effect was observed only in 11-month-old rats. Conclusions: Haloperidol and hyoscine butylbromide enhanced morphine analgesia. Future studies may explore the repeated administration of these drug combinations in rats and humans. © 2014 S. Karger AG, Basel.Pharmacology 11/2014; 94(5-6):207-213. DOI:10.1159/000365220
Article: Efficacy and Safety of Prolonged-Release Trazodone in Major Depressive Disorder: A Multicenter, Randomized, Double-Blind, Flexible-Dose Trial[Show abstract] [Hide abstract]
ABSTRACT: Objective: To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). Methods: In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for 6 weeks. The primary efficacy measurement was the change of the 17-item Hamilton Depression Rating Scale (HAMD-17) total score from baseline to the end of the study. The secondary efficacy measurements were the response and remission rates, the Clinical Global Impression - Improvement of Illness (CGI-I) score at the end of the study, and the change of the HAMD-14 total score and quality of sleep [evaluated by the Pittsburgh Sleep Quality Index (PSQI) scale] during the study period. Results: The mean maximum daily dose was 273.11 mg for the trazodone group and 290.92 mg for the placebo group. At the end of the study, there was a significant difference between the two groups in the HAMD-17 change score (trazodone vs. placebo: -11.07 vs. -8.29, p < 0.001). Trazodone showed advantages at 1 week of treatment, and the effect lasted until the end of the study (week 6). The response and remission rates of the trazodone group were significantly higher than those in the placebo group (response rate: 59.6 vs. 37.2%, p < 0.001; remission rate: 35.5 vs. 22.2%, p = 0.005). The majority of the adverse reactions of trazodone were mild to moderate, and the most frequent adverse reactions (≥5%) were dizziness, dry mouth, somnolence, and nausea. Conclusions: Prolonged-release trazodone was more effective than placebo in MDD and was well tolerated.Pharmacology 11/2014; 94(5-6):199-206. DOI:10.1159/000368559
Article: Pharmacokinetics and Pharmacodynamics following Intravenous Administration of Recombinant Human Hepatocyte Growth Factor in Rats with Renal Injury[Show abstract] [Hide abstract]
ABSTRACT: Background/aim: Hepatocyte growth factor (HGF) plays a role in the regeneration and protection of the kidney, but little information is available concerning the pharmacokinetics of therapeutic treatment with HGF. In this study, HGF was administered after the onset of renal injury, and pharmacokinetic analysis was performed simultaneously with an efficacious dose. Methods: For the study of pharmacodynamics, recombinant human HGF was intravenously administered to rats with glycerol-induced acute kidney injury (AKI). In the pharmacokinetic study, rats subjected to glycerol injection or renal ischemia-reperfusion were used as models of AKI, and rats subjected to 5/6 nephrectomy were used as models of chronic kidney disease (CKD). Results: After intravenous administration of HGF at doses of 0.5-2.0 mg/kg, the elevation of blood urea nitrogen was suppressed, indicating that HGF had a pharmacodynamic effect. However, no significant difference was seen in the pharmacokinetic parameters such as clearance, distribution volume and half-life between the normal, AKI and CKD groups. Conclusion: The intravenous administration of HGF after the onset of renal dysfunction exerted a pharmacological effect on AKI, and renal injury did not affect the clearance of plasma HGF. This unaffected profile may serve as a base for the safety of HGF during therapeutic administration.Pharmacology 10/2014; 94(3-4):190-197. DOI:10.1159/000363412
Article: Pharmacokinetic Evaluation of a Novel Benzopyridooxathiazepine Derivative as a Potential Anticancer Agent[Show abstract] [Hide abstract]
ABSTRACT: Background/aims: The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. Methods: The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. and oral administration of 10 mg/kg were performed by the HPLC-mass spectrometry method. Results: Following a single i.p. dose of the BPT derivative, the plasma concentrations showed a biexponential decay (with a rapid decline) followed by a slow decay with a terminal half-life of 77.90 min. The area under the concentration-time curve from time 0 to infinity (AUC0-∞) was 18.90 µg/ml·min. After oral administration, the plasmatic concentrations reached a peak of 0.06 μg/ml at 35 min and then decayed with a half-life of 108 min. The AUC0-∞ was 10.25 µg/ml·min, representing 54.2% of the relative bioavailability. The compound was well distributed in the body, and its elimination seemed to be fast, regardless of the administration route. The major metabolic pathways were demethylation and hydroxylation reactions, both followed by conjugation with glucuronic acid. Conclusion: In rats, the BPT derivative is well distributed and undergoes extensive metabolism, leading to several metabolites. With promising in vitro activity and very good oral bioavailability, this compound seems to be an attractive candidate for further development as an anticancer agent.Pharmacology 10/2014; 94(3-4):170-178. DOI:10.1159/000368084
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


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312 pp., 6.125 x 9.25, 7 illus., 8 maps, 2 tables, notes, bibl., index
Race, Nation, and the Politics of Landownership in Oklahoma, 1832-1929
The Color of the Land brings the histories of Creek Indians, African Americans, and whites in Oklahoma together into one story that explores the way races and nations were made and remade in conflicts over who would own land, who would farm it, and who would rule it. This story disrupts expected narratives of the American past, revealing how identities--race, nation, and class--took new forms in struggles over the creation of different systems of property.
Conflicts were unleashed by a series of sweeping changes: the forced "removal" of the Creeks from their homeland to Oklahoma in the 1830s, the transformation of the Creeks' enslaved black population into landed black Creek citizens after the Civil War, the imposition of statehood and private landownership at the turn of the twentieth century, and the entrenchment of a sharecropping economy and white supremacy in the following decades. In struggles over land, wealth, and power, Oklahomans actively defined and redefined what it meant to be Native American, African American, or white. By telling this story, David Chang contributes to the history of racial construction and nationalism as well as to southern, western, and Native American history.
© 2015 The University of North Carolina Press
116 South Boundary Street, Chapel Hill, NC 27514-3808
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My review
Original recipe yields 16 servings
Based on a 2,000 calorie dietSee full nutrition
Ready In
I made the icing first. It turned out a hot mess because it was just pure butter with pineapple flavoring (from the juice). Luckily I was able to whip it into shape by adding MORE confectioners ...
Amazing! Very good recipe. I used It to make the most beautiful double layer coconut raspberry cake.
No access to coconut milk here in Mexico, but did find Cream of Coconut, which I used half cup this & half milk. Cake is very grainy-I would advise using parchment paper on bottom of cake pans-I...


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The Profoto ZoomSpot is a superb, large focusable light shaping tool that creates a stage lighting effect, an accent light over a large distance, or background projection.
The zoom lens is adjustable from a 15 to 35 degree light spread and has a revolving lens unit to simplify lighting adjustments. The Profoto ZoomSpot also has integrated support for filters, gobos and masks.
It comes with a 300 watt modeling light and can handle up to 4800 watt seconds through its incorporated flashtube. It can be used with Acute, D4 and Pro-7 generators.


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R3 Nordic Society of Cleanroom Technology, Copenhagen, Denmark
Presentation Dates: May 14 – 15, 2012
Abstract Title: Advantages of Single Use Bioreactors vs. Conventional Steel Bioreactors
Presenter: Ronni Glenn Refstrup Hansen, Manager Cell Culture Manufacturing
60th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, Vancouver, BC, Canada
Presentation Dates: May 20 – 24, 2012
Poster Title: Protein Therapeutics: Structural Characterization, A simple strategy to perform parallel mAb disulfide bond assignment and polypeptide sequence confirmation
Presenter: Xian Huang, Senior Development Scientist, Analytical and Formulation Development
2012 American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference, San Diego, CA
Exhibition Dates: May 21 – 22, 2012
CMC Biologics will be exhibiting at Booth P504. Stop by to learn about our comprehensive Analytical Formulation and Stability standalone services offering.
IBC Life Sciences Single Use Applications Conference, San Francisco, CA
Presentation Date and Time: Monday, June 4, 2012 at 11:2
|SOURCE CMC Biologics
Copyright©2010 PR Newswire.
All rights reserved


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I'm DC RAINMAKER…
I swim, bike and run. Then, I come here and write about my adventures. It's as simple as that. Most of the time. If you're new around these parts, here's the long version of my story.
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Check out my weekly podcast - with TRS Triathlon, which is packed with both gadget and non-gadget goodness!
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In Depth Product Reviews
You probably stumbled upon here looking for a review of a sports gadget. If you're trying to decide which unit to buy – check out my in-depth reviews section. Some reviews are over 60 pages long when printed out, with hundreds of photos! I aim to leave no stone unturned.
Read My GPS Recommendations.
Here's my most recent gadget recommendations guide (Winter 2014-2015 edition) – covering almost every category of sports gadgets out there. Looking for the equipment I use day to day? I also just put together my complete 2015 'Gear I Use' equipment list, from swim to bike to run and everything in between (plus a few extra things). And to compliment that, here's The Girl's (my wife's) 2015 list. Enjoy, and thanks for stopping by!
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I enjoy explaining new things to folks – especially showing people how to get the most from their gadgets. Here's an ongoing list of "How to" guides.
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It turns our I've written a fair bit of stuff over the past few years – and after it disappears from my front page, a lot of it never really sees the light of day again without Google'ing skillz. Or a photographic memory…which I don't have. I've taken a look back and found stuff that…continues to find a trickle of readers via web searches or forum links.
Have some fun in the travel section.
I travel a fair bit, both for work and for fun. Here's a bunch of random trip reports and daily trip-logs that I've put together and posted. I've sorted it all by world geography, in an attempt to make it easy to figure out where I've been.
Tag Archives: LeMond Fitness
LeMond and the LeMond Revolution Trainer are back in business
Just a quick post, as I'm heads down in a bunch of other items at the moment (including procrastinating going out running 90 minutes in some rather chilly weather). To catch those of you back up – last fall LeMond … Read More Here
Tidbits: Initial thoughts on LeMond Trainer, me being on TV Tuesday Night
Things have been pretty busy as of late – with trying to knock out some big ticket items for work before the holidays, so tonight's post is going to a be a bit brief. First up was my first ride … Read More Here
Point to point long runs and unpacking the LeMond Revolution Trainer
Sunday I had my weekly long run, which this week stood at 15 miles, though, by next week it'll be up to 18 miles. I'm still trying to figure out how I got conned into my long run changing from … Read More Here
Behind the scenes: LeMond Fitness
The guys at LeMond Fitness offered a tour of their facility over a year ago, when I first met the at the 2010 ANT+ Symposium. Given I'm often in Seattle to visit family, it was just a matter of time … Read More Here
Week in Review–October 10th, 2010
I've long since wondered what to do with all the random tidbits of things I collect each week – or the little thoughts that don't quite make for a full post. But I finally came up with a solution: The … Read More Here
Spending time with the LeMond Revolution Fitness ANT+ Trainer
There were/are very few non-bike vendors at Interbike that actually show up at BOTH the Outdoor Demo, and the Indoor Expo. In fact, I think PowerAde was probably about the only other one. But perhaps that shows something about the … Read More Here
Demo Day 1 at Interbike
While I've got all sorts of product and feature specific items lined up all week long, today's first day at the Outdoor Demo was more about getting a lay of the land. Lots of land. The drive is about 30-45 … Read More Here


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You can go to work or you can be the boss. The choice is yours.
"Susie helped me improve my sales process and lead generation. Within the first four weeks of working together I up-sold all my current clients and I gained 3 new clients! I earned over $10,000 in just 90 days. Susie's style is down-to-earth, but fierce at the same time."
Amber Lilyestrom
"After just one month I booked 8 new clients and have a solid baseline income! Hiring you as my business coach has been that push I needed to get my ideas into real income."Elena Lipson
"Susie's action-oriented coaching is exactly what I needed to up level my previously-stagnant "hobby" into a legitimate POWERHOUSE of a business. Now my calendar is filling up with clients and previously unimaginable opportunities, and I'm FINALLY getting paid to do work that I love! If you're considering working with Susie, don't hesitate. She's a HELL YES!"Nicole Bernardo


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As Idaho Booms, Prisons Fill And Spending on Poor Lags
Published: April 16, 1998
(Page 2 of 2)
''There are good reasons for building prisons,'' said Professor Robert Marsh, chairman of the Department of Criminal Justice at Boise State University, ''but our one solution to everything -- drugs, alcohol abuse, minor offenses -- is prison, and that is simply not cost-effective.''
In 1996, the last full year for figures, 78 percent of those Idaho sent to prison were nonviolent offenders -- more than 50 percent higher than the national average. Yet Idaho's overall crime rate ranks it in the lower fifth among states.
Idaho's prison population, at more than 4,000, has grown tenfold in the last 25 years. Simple drug possession, writing a bad check, drunken driving and driving without a valid license can land a person in prison, though the Governor just signed a bill that raised the thresholds for those felonies.
In addition, 10 years ago Idaho became one of the few states to eliminate parole for good behavior. ''The average time served now, for any crime, doubled in 10 years from 22 months to about 44 months,'' Professor Marsh said.
The state is now spending $200 million to build a new, privately operated prison for 1,250 inmates. Its spending for the poor totals only about $15 million a year, at the bottom among all states.
Welfare payments are no more than $276 a month for a family, regardless of size, and there is a lifetime limit of two years for receiving aid. Some critics say the predominant attitude toward the poor is punitive. Some of those who used be on welfare certainly feel stigmatized.
''I find myself sometimes going for days without food so my kids can eat,'' said Krista Ziebart, an epileptic mother of two from the Boise area. Ms. Ziebart lost her welfare benefits when Idaho became one of only three states that count Social Security disability payments as income that would disqualify someone from welfare.
Ms. Ziebart is one of hundreds of people in Idaho who have left the welfare rolls, but have not necessarily been lifted out of poverty. Though they are uncertain, state officials attribute the drop to the new time limit of two years and a host of new requirements.
''A lot of these families that the state kicked off welfare have had to move in with other families or relatives, so it's not unusual now to find 9 to 12 people living in a single trailer,'' said Mikey Krajcer, director of the Hunger Action Network, a private nonprofit agency that works with the poor here.
A number of researchers and educators from Idaho have joined national critics in arguing that the state's investment in welfare and early child education is too low.
One recent study, financed by the state, found that nearly 60 percent of fourth graders were reading at a level below their grade. Another survey echoed national studies in establishing a direct link between failing grades for poor children by the fourth grade and the likelihood that the children will commit crimes as a juvenile or young adult.
''The message our state seems to be sending is that if you're going to be a kid, don't be a kid in Idaho,'' said Robert Barr, dean of the College of Education at Boise State.
''I have tried to convey to the state Legislature the most chilling information that I've ever seen,'' Dean Barr said in a interview. ''If a child is poor, is held back at least once and is not reading at grade level, you can predict with better than 90 percent success that the child will never graduate from high school and may end being a burden on the system, in prison or elsewhere.''
Earlier this year, the Legislature turned away Federal money that would have provided health insurance for more than 10,000 poor children, at only a small cost to the state.
After a furor, and lobbying by Governor Batt, some of the Federal money was restored last month, but not the full amount to which the state was entitled. State budget writers said they did not want to become dependent on Federal largess.
''Idaho is rock-solid, good families,'' Dean Barr said. ''Unfortunately, people are very suspicious of Government schools or Government help.''
They have become even more suspicious in recent years, as Idaho lost its Democratic office holders. The party's decline can be traced to the disappearance of its strong union base in the north, where minimum-wage service workers have replaced industrial labor. The last Democratic power in the state was Cecil Andrus, a four-term Governor until 1994.
A decade-long surge of newcomers, primarily from California, also changed the state's politics. Most experts now think that the new residents were fleeing more racially and politically diverse states, and are perhaps more conservative than many Idaho natives.
Governor Batt said there would seem to be ample jobs for the poor.
Asked why they could not get jobs, some mothers with families who have been forced off welfare said it was too hard to live on the minimum wage while trying to take care of young children.
What is more, some Idaho officials have indicated they do not want too many well-paying jobs to come to the state, because it would raise wages for others. Last year, the president of the Boise Area Chamber of Commerce, Jay Clemens, said he opposed a company's plan to bring 500 jobs to the area because it could ''unrealistically drive up wages.''
The state has a strong private welfare tradition through the Mormon church, to which about a third of Idaho's population belongs. But the church welfare system generally applies only to Mormons.
If you are poor and non-Mormon, there are few places to go, said some people here. ''They just want us to disappear,'' said Sherry Meschler, a disabled mother of three who lost her welfare benefits last year.
Photo: Krista Ziebart, an epileptic mother from outside Boise who lost her welfare benefits, says she sometimes goes without eating to feed her two children, including Kyle. Critics say Idaho wants its poor to disappear. (Glenn Oakley for The New York Times)(pg. A16) Chart: ''BY THE NUMBERS: Idaho's Poor'' Idaho is near the bottom of states in spending for children, and at the top in reported child abuse. Welfare rolls have been slashed . . . Graph shows number of Welfare recipients in Idaho, from 1990 through 1997. 1993-1997 percentage change Idaho: -77% United States: -31% . . . welfare spending for children is low . . . Per capita state spending for child welfare, excluding Medicaid, in 1996. HIGHEST THREE STATES New York: $99.30 Vermont: 93.54 Illinois: 91.99 LOWEST THREE STATES Hawaii: $20.10 Idaho: 17.00 S. Dakota: 15.12 . . . and reported child abuse is high Children reported as abused or neglected per 1,000 children in the population, in 1995, and percentage change 1986-1995. HIGHEST THREE STATES % increase Idaho: 112.4 children 179% Missouri: 70.1 12% N.C.: 64.0 182% (Sources: Administration for Children and Families; Child Welfare League of America)(pg. A16)


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Hey, I'm Maren!
Münster, Germany · Member since March 2013
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Hello hello!
My name is Maren, I am a 27 year old Communication Trainer & Coach. After having lived in Dublin for about 3 years, I enjoy being back in Germany and especially in the beautiful Muenster.
Still my boyfriend and me have just started to travel the world :)


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Oktoberfest in Dubai
The best places to get your fix of the German hop festival Discuss this article
- Picture 1 of 2
The annual Oktoberfest hop festival originated in Munich, Germany, in 1810, when festivities were held to celebrate the wedding of Princess Therese of Saxony-Hildburghausen to Crown Prince Ludwig (later King Ludwig I). In Germany the annual celebrations take place over a period of 16 to 18 days, and usually run from late September to the first weekend in October, although in Dubai things kick off a little later. With the biggest and best-known of Dubai's Oktoberfest celebrations opening on Wednesday September 12 at the Grand Hyatt and Dubai Cricket Stadium, we take a closer look at these two, plus four more spots to get your fix of bratwurst and Bavarian brews. Prost!
Grand Oktoberfest
Now in its fifth year, the Grand Hyatt's hop festival will take place in an air-conditioned tent decked out in the authentic Bavarian style. Though there are no drinks deals, there are four different types of German hops available, as well as all manner of Bavarian dishes – there will also be a Friday brunch (alcohol must be bought separately) on October 14, 21 and 28 from 12.30pm until 4.30pm. At last year's celebrations, 3,468 Nuernberger bratwurst, 822 Municher sausages and 800 pretzels were consumed, and more than 9,000 litres of hops were sold. In 2010 the brunches were fully booked within days, and a total of 6,000 guests visited the tent – in fact, 33 per cent more hops were consumed per head at the Grand Hyatt's Oktoberfest than at the original celebration in Munich.
This year, oompah band Die Kirchdorfer will be flying in from Munich's Hacker Tent to provide tunes every night. The hotel is expecting to cater for more than 8,000 guests during the period, so book early for brunch – there will also be a laides' and mothers' night every Tuesday, with deals for women. Expect a party atmosphere with plenty of people in fancy dress.
Free entry. Sat-Wed 7pm-1am; Thu 7pm-3am; Fri 12.30pm-4.30pm, 7pm-3am. October 12-29. Grand Hyatt Dubai, Oud Metha (04 317 2271)
Oktoberfest-Wiesn Party
On Friday October 7, The German Emirates Club and The Els Club will host what they claim is the biggest Oktoberfest in the Middle East at Dubai International Cricket Stadium in Dubai Sports City. Set up in tents like the original Munich festival, the event will have a capacity of up to 5,000 revellers, and will host all manner of activities. Expect a bouncy castle, bucking bronco, face painting and a football competition during the day. In the evening, the Oktoberfest-Wiesn Party kicks off with live music from Bavarian band Bayern Express, while German DJ Sabrina Terrance will play a mix of Bavarian sounds and hits to get everyone on the dancefloor. There will be competitions for the best dirndl (a traditional Bavarian dress) and yodelling, so dig out your outfit and get practising.
Dhs95, including one free glass of hops. Doors open noon. Dubai International Cricket Stadium, Sports City. (050 819 7973)
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Need to face reality - 9 Comments
I thought we all agreed that our nation has a debt crisis. It turns out I was wrong. There is now a movement by the Democrats to convince people that $16 trillion of debt is not a worry. Yikes.
I have always agreed with conservatives, Sen. John McCain and even Democrats that President Bush spent like a drunk sailor. Yes, he did have the new war on terrorism, but overall he increased federal spending too much.
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Cedar Grove Acd's
Pam Phillips
587 Barlow Rd
Virgilina VA 24598
Phone: 434-470-4034
E-Mail: email@example.com
Akc registered blue and red heelers I now have two national and international champions this year and new puppies on the way
Cedar Grove Acd's
Pam Phillips
587 Barlow Rd
Virgilina VA 24598
Phone: 434-470-4034
E-Mail: email@example.com
Akc registered blue and red heelers I now have two national and international champions this year and new puppies on the way
Barlow Kennel
Pam Phillips
E-Mail: email@example.com
Akc registered blue and red heelers excellant quality and temperment all puppies come with a 1 yr health guarantee shot/worm records and are sold as pets
Riegle Animal Care
Cynthia Riegle
3434 fosters branch rd
Charlottesville VA 22911
Phone: 203-449-8349
E-Mail: firstname.lastname@example.com
Excellent breeding in both our female English Labrador retriever and our Tennessee bred black and white Bassette Hound. Both dogs have exceptional dispositions, confirmation and intelligence true to their breeds and will have their first litter of Basador puppies in March 2015.
Please be aware that their will be an application and reference check list. We are looking for a family who has experience and knowledge on how to raise a puppy in a positive manner.
Warrenton VA 20115
E-Mail: firstname.lastname@example.com
Located in the state of Virginia, KODAK Alaskan Malamutes is proud to bring you some of the most impressive dogs in the breed. Rare unique old lines are preserved and raised in a family environment. Our dogs exhibit incredible quality, type and presence. KODAK Malamutes have owned and bred quality Alaskan Malamutes since 1988. All of them are AKC registered dogs that recreate the original breed standard. Looking for responsible owners and a family environment. 4 males available. Taking deposits now. (540)466-0076. Leave message and phone # or email firstname.lastname@example.com.
The Chihuahua Dawghouse
Phone: 434-607-0642
E-Mail: firstname.lastname@example.com
I have several puppies for sale. Males and females different colors available. Ready to go now. Check out "The Chihuahua Dawghouse" on Facebook for pics & info or email or text Amy
333 Rinaca Lane
Shenandoah VA 22849
Phone: 540 742 3752
E-Mail: firstname.lastname@example.com
I breed Australian Shepherd in my home with my family. The puppies are raised around other dogs and cats as well as chickens
Mrs. Frogel
Jewell Frogel
285 Pine Grove Road
Austinville VA 24312
Phone: 276-728-5383
E-Mail: email@example.com
I have four Maremma puppies for sale. Three are females and one is male. They are white fluffy, adorable little puppies. These puppies will grow to be wonderful guard dogs for farm animals and your family. They have a keen sense for when predators are approaching. These white loyal puppies are 100% purebred Maremma sheepdogs
K.C.Hidden Mysteries Farm
K. C. Campbell
206 Knight Dr
Winchester VA 22602
Phone: 540-869-7601
E-Mail: email@example.com
We have been breeding quality pups for family pets as well as for showing for over 35 years. We give a full health guarantee with every puppy and do health screening on our parents. We are doing English and American lines of Golden Retrievers and also are also doing some of the hybrids. We raise all our pups in the home and they are handled daily. We live on a 55 acre farm and they get plenty of fresh air and real grass to romp in. We try very hard to work with all our clients and prefer not to ship but will consider all shipping on a case per case basis. We want to have people come and meet their puppies parents and pick your own puppy from the litter.
Animal Haus Chihuahuas
Robin Colley VA 24202
Phone: 276-466-8600
E-Mail: email@example.com
A quality Breeder specializing in adorable AKC registered Chihuahua Puppies for over 30 years. Over 30 years experience raising healthy & sound Chihuahua puppies. We raise both long and smooth coat chihuahuas in a variety of colors. All puppies are sold with a 5 year written genetic health guarantee, are AKC (American Kennel Club) registered & are up to date on vaccinations and dewormings appropriate for their age. Contact for more information, or visit our website for photos and information. All of our puppies are raised in a loving home environment & are well socialized with cats & other small dogs. Our puppies are raised for personality & will be a much treasured part of your family. All of our puppies come with their paperwork, copies of their contracts that you've signed, up to date shot & health records, puppy care pamphlets, their AKC registration papers, their baby photos, and a puppy gift package that includes a baby blanket, a bag of food, some treats, and some wonderful toys. Prices range from $200 & up for young adults, $500 & up for puppies. Unlike other breeders, we have specialized in Chihuahuas for over 30 years! We have been published and quoted in breed specific publications, newspapers, books, and magazines! Choose a breeder with a long standing reputation in Chihuahuas! Call (276) 466-8600, Email us at firstname.lastname@example.com or visit our website for photos of our puppies and information about them.
~*~Give yourself a gift that will return your love~*~
Dufenhof Swissies
Ellyn Signet
P. O. Box 488
Rixeyville VA 22737
Phone: 540-937-7956
E-Mail: firstname.lastname@example.com
Devoted to Swissies since 1992. AKC Breeder of Merit, Member GSMDCA.
Breeding AKC registered Greater Swiss Mountain Dogs for loving family companions at home and winning champions in the show ring. Dogs OFA/CERF screened. Please visit our website to learn more about the breed and any available Swissies.
Country Charm Farm LLC
Doug and Lisa Bowen
3070 Howard P Anderson Road
Halifax VA 24558
Phone: (434) 446-2131
E-Mail: firstname.lastname@example.com
We corrently have one 15 week old female available from a litter we had the last of Sept. in 2012. We have one adult breeding female, 2 young females and one male ready to breed in the fall on 2013. All are beautiful, excellent, breeder quality, registered Kangal Dogs.
Whispering Creek Boerboels
David Malcom
1570 back mountain rd.
dillwyn VA 23936
Phone: 434 983 1055
E-Mail: email@example.com
We are located in central Virginia, breeders of "The best of the best" Family and gaurd Boerboels.
Royal Puppy Paws
Phone: 540-785-0452
E-Mail: email@example.com
Beautiful yorkie babies!!!
Phone: 877-308-5386
E-Mail: email@example.com
Top Quality Goldendoodle and Aussiedoodle Breeder for over 16yrs, Tested parents, Puppies raised in our Country home with Service and Therapy in mind. Full 2yr Guarantee, Limited lifetime guarantee.Visit or main page for more info and to see puppies available http://www.DoodlesvilleVa.com
Boulder Brook Kennel
Bill Wright
PO Box 1
Markham VA 22643-0001
E-Mail: firstname.lastname@example.com
I have breeding and training hunting spaniels for 20 years including the Deutscher Wachtelhund and Boykin Spaniel. My litters are often registered with several registries. Am a founder of several national breed registries.
Carriage House Cockapoos and Goldendoodles
E-Mail: email@example.com
Website: http://www.carriagehousecockersandcockapoos.com
We are a purposefully small breeder so that our parent dogs are raised in our home. They are pampered and never kenneled outdoors and are all part of our family, well socialized and happy. We have over 15 yrs of breeding experience and take great care when breeding our dogs and
caring for puppies. Our Cockapoos and Goldendoodles are well socialized, imprinted and loved
from the moment they are born.
grindstone kennels
seldon conley
startannery VA 22654
Phone: 540-436-3775
E-Mail: email@example.com
i raise the caranthan line of bmc dogs one litter ever two years or so i have a litter ready now 8-31-2011
Grizzly Hollow Farm
Kathy Clarke
1644 Ebenezer Church Rd
Gore VA 22637
Phone: 540-888-3606
E-Mail: email@example.com
Website: www.grizzlyhollowfarm.com
We have a small farm outside Winchester Virginia-
I am a certified vet technician so you can rest assured that our pups get the very best of care !
Our dogs are handled daily and are part of our family!! We DO not and WILL not "dock"their tails-
God has given this creature his/her tail to help with their balance & herding ability & and we will not remove it…
They are wonderful,smart and extremely loyal dogs!
We will be glad to provide references at your request
540-888-3606 or cell 540-539-0608
Grandville Cavaliers
Leila Grandemange Virginia
Phone: 434-386-7450
E-Mail: firstname.lastname@example.com
Home to beautiful Cavalier King Charles Spaniel. Puppies occasionally available, raised as part of our family, well socialized and loved! AKC and CKCSC registered. We welcome your inquiries. Breed note cards and books also available.
Allen's Virginia Boerboels
Terry Allen VA
Phone: 804-449-6259
E-Mail: firstname.lastname@example.com
Pups are here. Known to be the best family and guard dogs. Our Boerboels are well built. Large boned with nice wide head, chest and rear. They have great conformation with great personalities and the natural guard dog instincts. We expect the same in our pups. The sire to the pups is Xilo (import from S.Africa) at 179 lbs. He is massive and very athletic. Please call to find out more about our new additions.
Fox Fire Jacks
Angela Thomas
2179 Saunders Grove Dr.
Moneta VA
Phone: 540-798-4414
E-Mail: email@example.com
Irish Short Legged JRT Puppies for over 17 Yrs.We breed for CALM, HEALTHY, INTELLIGENT puppies. Call or visit our web site for more info.
Sander-Haus German Shepherd Dogs
Central VA 22901
E-Mail: email@example.com
Sander-Haus German Shepherd Dogs offers quality German shepherd puppies from 100% European lineage to approved homes. Please visit our site for more info and availability.
Chi Stud Service
Manassas Virginia 20110
Phone: 571-377-1702
E-Mail: firstname.lastname@example.com
We run a Chihuahua Stud service. Our pride and glory is our 5yr old male rust colored short haired Chihuahua. He has no health problems at all. Our mating fees are low and negotiable. Please feel free to contact us.
Mountain Creek Kennel
Missy Roberts
Johnson creek road
Evington VA 24550
Phone: 434-369-6067
E-Mail: email@example.com
Breeding the standard APBT for Temperament and Conformation making the Ultimate Family Companion since 2000! Many references available! CH Bloodlines! York & Nevada
'PR'UKC puppies born 11-14-2010, Only 3 males available! taking deposits now to hold.
2 Chocolate & White red nose Males and 1 Chocolate Brindle & White red nose Male. Both parents are on site! VERY SWEET TEMPERED FAMILY PETS!!
Please call or email for more information.
More pictures, pictures of the parents and Pedigree on my website!
Dont forget to check out my Past Pups Page!
Located in Evington, VA
Pick up is VERY VERY WELCOME!
Shipping is avail in US but Extra!
Stony Creek Cane Corso
Donny Payne
Stony Creek VA 23882
Phone: 804-683-8188
E-Mail: firstname.lastname@example.com
Welcome to Stony Creek Cane Corso. We are a small breeder located in rural Stony Creek, Virginia.
Our goal is to produce top quality dogs with outstanding temperaments, and first and foremost, loyal and loving family companions.
We breed only hip tested, healthy dogs. Please do your research before committing to purchasing your new corso pup as they are not for everyone.
For any further information or questions please contact us.
Carriage House Cockapoos & Goldendoodles
Harrisonburg VA 22801
Phone: 540-325-6117
E-Mail: firstname.lastname@example.com
Carriage House Cockapoo and Goldendoodle puppies is located in the beautiful Shenandoah Valley of Virginia. We are dedicated to raising quality Cockapoo and Goldendoodle puppies with over 15 yrs of breeding experience. We do not have a kennel based program. We are purposefully small so that all of our dogs can be raised in our home as part of our family. Our moms are never alone during labor and delivery. The puppies are handled with love and care from the moment they are born. All puppies come with a one year health guarantee and a lifetime of support.
915 Bobwhite Place
Harrisonburg VA 22802
Phone: 540-578-6379
E-Mail: firstname.lastname@example.com
We are located in the Shenandoah Valley. All of puppies are tri color (black/orange/white) Our Fr.Ch. sired, Dynamo Dakota De Plum Creek is the sire of a litter born 4-7-10. Many Champions in Pedigree! French and Ireland blood lines. We offer a 2 Yr Guarantee.
Dream Team Kennels
Ish & Kim Moore
Tar Heel NC 28392
Phone: (804) 677-1695
E-Mail: email@example.com
Dream Team Kennels Est. 1998. We breed World class dog for Show and Work. All pups come with lifetime support and health guarantee.
Kenda Deford
Kenda Deford
Ashland VA 23005
Phone: (804) 798-3078
E-Mail: firstname.lastname@example.com
Breeding quality AKC Miniature Schnauzer puppies. Our small breeding program is located in central VA and we are dedicated to producing Mini Schnauzers that possess excellent structure, superior temperaments and sweet, loving personalities. All of our puppies are raised in the home and underfoot. They are AKC registered, current on shots and dewormings and socialized daily. Hand delivery is available to most major US cities. Please contact me for additional information.
Bison Ridge ACD'S
Pam Phillips
1378 Buffalo Springs Rd
Buffalo Jnct VA 24529
Phone: 434-470-4034
E-Mail: firstname.lastname@example.com
Breeding for quality and temperment what a cattle dog should be within Akc guidelines for a cattle dog .Very well socialized ready for new homes Shots and wormings UTD Genetic health gurantee
HSOT Chows
Tammy Tosh -1
Phone: 540-489-7922
E-Mail: firstname.lastname@example.com
We are a small hobby kennel who will occasionally have a pet quality companion available from a breeding to obtain show quality puppies for the continuation of our lines. We only sell to responsible homes, you will be required to neuter a pet quality companion.
Alpha Wolves
Abilene Ave
Norfolk, Virginia 23502
Phone: 757-816-5310
Arctic, Tundra, Timber, And Red Wolves. Siberian Huskies, Alaskan Malamutes, And Samoyed's
Carriage House Cockers and Cockapoos
Edinburg, Va 22824
Phone: 540-325-6117
We are a small hobby breeder of Cockapoo and AKC registered Cocker Spaniel puppies. We are purposefully small so that all of our dogs are never kenneled outdoors. They live in our home and when we go outside, we all go together. We have 2 rooms in our home designated just for puppies and moms. Our nurseries are genuine nurseries designed for babies' and mom's comfort.
Virginia Miniature Schnauzers
Virginia 23005
Phone: (804)798-3078
Our puppies are bred for personality, conformation, temperament and health. We work hard to socialize and stimulate our Mini Schnauzer puppies on a daily basis, exposing them to a variety of people, noises and new environments. We believe that this makes for a happier and more adaptable adult Miniature Schnauzer.
Borne iN the Bone Kennel
Samuel Piper
500 Beagle Run Lane
Alberta, Va. 23821
(434) 676-3355
Breeding cow and big game dogs
Windy Hill Biewers and Yorkies
Valerie Kibler
Woodstock VA 22664
Small Yorkshire Terrier Female
Clyde and Kelly
P.O. Box 2422
Abingdon VA 24212-2422
Phone: 276-619-5582
Honeii St.clair!
Olney Stewart
1207 Old Atlantic Ave.
Chesapeake VA 23324
Phone: 757-962-9811
Phone: 757-962-9811
Beach Yorkies
Virginia Beach Va 23464
Piney Mountain Puppies
Michelle Dinwiddie
334 Piney Mountain Rd.
Narrows VA 24124
Phone: 540-726-3334
Fax: 540-726-3334
Tivoliz Vizslas
Arlington VA
Unleashed Toy Australian Shepherd
KC Murphy
955 Hylton Hollow Rd
Willis VA 24380
Phone: 540-789-7898
Ivy Gables Tibetan Terriers
Elizabeth Wilson
2792 Long Acre Rd.
Palmrya Va. 22963
Phone: 434-953-5491
Standard Poodle puppies
Coleman Falls VA
Shinese Puppies
Jeremiah Gatlyn
Merrimack Landing
Norfolk va 23503
Phone: 757-729-5258
Fireside Shiloh Shepherds
Sam Knaus
Appomattox VA
Phone: 434 352 4680
Abba's Shilohs :Bianca/Luke
Michelle Wirrell
Bluemont VA 20135
Phone: (540) 955-4180
Redbone Coonhounds
Renee Bandy
PO Box 7623
Roanoke VA 24019
Phone: 540-529-2336


text:
Deviant Art
Hangover (Link X Reader)Part 2 of this: http://sweetiu.deviantart.com/art/Drunk-Cuddles-Link-X-Reader-463704741Hangover (Link X Reader)1 year ago in Romance
(A/N: I started to write this but somehow I deleted all of it and I was halfway through it SAJDFSGFEHGUE and also, slight lime.)
Link woke up with a terrible headache and a feeling of restlessness. His blonde hair was a tangled mess over his eyes, and he felt extremely sick. He tried to sit up but his head felt like a brick. Brushing his hair out of his eyes with his fingers, his eyes widened when he realized he was in the same bed as someone.
"What did I do?" He thought worriedly. He gently poked the back of the person, and they stirred and turned to face him. He relaxed slightly when he realized it was only you. But he was still quite shocked at the fact that you were sharing a bed. You two are a couple, but you don't share a bed. Yet.
He started prodding your soft cheeks gently. "(Name)..." He muttered. You stirred a bit, and finally woke, giggling.
|Sta.sh Submit


text:
A new podcast from Marketplace and Quartz: Actuality
Jul 9, 2015
Plugging you into the conversations behind the news.
My Paris Dream: A fashion journalist on style and slang
Interview by, Produced by
May 12, 2015
A fashion journalist on what she learned in Paris.
My First Job: Junior Journalist
Produced by
Apr 29, 2015
Richard Stolley got his first job as a journalist at the age of 15.
Oh, for the want of a decent copier
Mar 18, 2015
The State Department needs more copy machines to clear up this backlog.
What makes a good writer at Sports Illustrated?
Aug 18, 2014
An internal document shows Time Inc. is rating how writers benefit advertisers.
Why long-form journalism is everywhere these days
Dec 27, 2013
Despite seemingly shrinking attention-spans, in-depth reporting is making a comeback.
Wall Street Journal battles for freedom of the press in Britain
Oct 18, 2013
The British government is trying to prohibit The Wall Street Journal from publishing the names of trades implicated in the LIBOR scandal.
eBay founder Pierre Omidyar plans new media company
Oct 17, 2013
The founder of eBay gets into the news business, even recruiting Glenn Greenwald, who brings with him a trove of unpublished security documents from Edward Snowden.
AOL's new hyper-local news plan: A little less local
Aug 12, 2013
AOL hoped to create a viable new model for local news, but now it's planning dramatic cuts to Patch sites and staff.
Americans don't think journalists contribute a lot to society
Jul 11, 2013
The military topped a survey of occupations in the U.S. that people think "contribute a lot" to society.


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Home > Product Categories > Pro-Video > Video Converters > Video Standards Converters > TERANEX 2D PROCESSOR
Item #: BMD-TERANEX-2D MFG #: TERANEX 2D PROCESSOR
List Price:$1,995.00Our Price:$1,895.25Quantity Pricing
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The world's leading standards converter lets you move between hundreds of video formats instantly!
Teranex is the world renowned standards converter with incredible virtually transparent quality! Broadcast masters are converted with full quality allowing worldwide distribution. Teranex is perfect for live production and, with the built-in ThunderboltT port, can also be used for cleaning and converting content for authoring as well as video capture and playback for editing, design and effects! Teranex is the perfect video converter, standards converter and capture and playback tool all in one!
Teranex simply provides more conversion than any other solution. It includes extremely high quality de-interlacing, up conversion, down conversion, SD and HD cross/standards conversion, automatic cadence detection and removal even with edited content, noise reduction, adjustable scaling and aspect ratio conversion. All with full timecode and multi-channel audio conversion. Also includes 3D dual channel conversion, patent pending 3D simulation and 3D camera rig alignment!
Use Anywhere!With the ability to convert from virtually any television format to any other television format at the highest quality, Teranex has hundreds of uses in any broadcast and post production facility. Use Teranex for general conversion as well as protecting decks, transmitters/encoders and switchers from video standards they don't support simply by installing Teranex before the video input! Add Teranex into OB vehicles to synchronize and convert video feeds, even in 3D!
Teranex QualityAdvanced SIMD technology developed and patented by Teranex allows instant calculations on thousands of pixels simultaneously in X, Y positions and between video frames, so you get true super computer imaging power. Processing is applied within the frame and between frames all at the same time, so you get better de-interlacing, inter-frame interpolation and noise reduction. This is why Teranex conversions are indistinguishable from the original master!
Advanced Processing PowerTeranex 2D and 3D Processors feature patented processing technology for the highest quality conversion between video standards, frame rates and resolutions. The incredible power of Teranex processing includes; Up Conversion, Down Conversion, SD/HD Cross Conversion, SD/HD Standards Conversion, Cadence Detect and Remove, Noise Reduction, Adjustable Scaling, Aspect Radio Conversion, Smart Aspect, Converts Timecode, Includes 16 Channel Audio, 3D Camera Align, 3D Dual Channel Standards Conversion, 3D Simulation.
More ConnectionsWhen working in high end formats such as 4:4:4 and 3D, the Teranex 3D Processor includes dual SD/HD and 3 Gb/s SDI input and output for dual link 4:4:4 as well as single link 3 Gb/s SDI 4:4:4. The dual channels also allow true full resolution left and right eye 3D processing where both eyes are converted at the same time in perfect sync! When running true full resolution dual stream 3D, the HDMI connection and Thunderbolt capture and playback support dual stream 3D via the single cable.
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This is great!
By Colovideo
from Denver
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Comments about Blackmagic Design Teranex 2D Processor All Format Standards Converter:
We use this in one of our control rooms and it works great.
Bottom Line Yes, I would recommend this to a friend
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This was a nice clean motel a short walk to the beach, 1 block from Busy Bees Bagels. It doesn't have tons of frills but nice breakfast bites, &a pool. Kept clean by staff & pleasent staff in office. Thanks Olga..
Review collected in partnership with Travelodge
I'd like to thank the hotel staff for their overall good service. It's out second time. Location is feet right near windensea beach. Walking distance to la jolla cove. The room are a bit old, no flat screen tv, the bed and pillows are not the most comfortable. Overall though maybe the best value in la jolla. Will come back.
Though a good price for the area, are room was dark, dingy and depressing. Possibly our room was the only one like this but there were holes in the backing of the dated drapes, tub very slow to drain, strips of tape in the tub were peeling. There was also a chemical smell to the room.
This is our second stay here.Everyone is very friendly and helpful.The location is perfect for us to walk to most activities and eat.We plan to return again and again.
The hotel location and staff were wonderful. There are a couple rooms, however, that are in a hallway area such that the room is very dark as the window faces the hall. We were in one of those rooms. Also, the room was next to a storage area that the service team uses, and cabinets across the hall were also used by this team. Thus, between 7 and 7:30 we could hear loud talking as carts were being stocked, and noise behind our heads in the storage room as supplies were being gathered. As all the rooms were booked we were unable to move to another room.
The staff is as good as it gets, and the location is epic! One block to the legendary Wind&Sea beach. Clean and functional rooms, and a nice hot spa to sit in after a surf. Great food within walking distance is an added bonus. Highly recommended, Location, Location, Location.
The only thing puzzles me why get a key & fill out paper just to get to the Jacuzzi? This is a multi-million $ neighborhood, not Russia! I was lonely in there, nobody else bothered! Kind of unfriendly! Maybe the bums come in?? Breakfast was OK. And checkout is at noon! Reasonable!
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Thank you to our volunteers and sponsors for making our clean-up event another success!
Michigan Cares for Tourism is a 100% volunteer, 100% give-back partnership between Michigan tourism organizations where we come together to help restore Michigan's historic attractions, learn about a Michigan tourism destination, and network across our industry segments to ultimately enhance the visitor experience, and be more involved professionals. Come volunteer at our 2015 clean-up sites and make a difference at these valued attractions that need our help. The two day experience includes an optional evening FAM tour of the interesting area attractions, and the next full day is designed to restore the site. Please share your time, talents, and/or resources and register as a volunteer or sponsor today!
The Fayette Historic State Park Clean-up Event is now SOLD OUT!
ITINERARY FOR FAYETTE 2015Attractions / Things To Do
in Manistique


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text:
Mike Tirico and Jon Gruden look ahead to Lions vs. Seahawks on Monday Night Football. Catch all the action on ESPN starting at 8:15 p.m. ET.
Gruden: Lions 'in for a real difficult night' in Seattle on MNF
Publish Date: Yesterday, 10:02 PM ETDuration: 01:31
Gruden: Lions 'in for a real difficult night' in Seattle on MNF
The Broncos can't stop AP, but that's ok
Swami Sez: Week 4 picks
Jets have playmakers to defeat slumping Dolphins
All signs point to yes for Brees' return
Bruschi calls the Colts a bad football equation
Ex-NFL WR Fryar sentenced to 5 years
Luck appears to have taken a step back
Schlereth: Colts O-line play horrendous
Cruz 'not sure' when he will return
Patriots head into bye week undefeated
Alshon Jeffery out Sunday vs. Raiders
Bills taking cautious approach with McCoy, Watkins
Luke Kuechly out again for Panthers
Jets roll into London
Marqise Lee's injured hamstring causing more problems
- Gruden: Lions 'in for a real difficult night' in Seattle on MNF
- (01:31) Yesterday, 10:02 PM ET
- The Broncos can't stop AP, but that's ok
- (01:00) Yesterday, 11:42 AM ET
- Swami Sez: Week 4 picks
- (01:23) Yesterday, 10:21 AM ET
- Jets have playmakers to defeat slumping Dolphins
- (01:16) Yesterday, 01:55 PM ET
- All signs point to yes for Brees' return
- (00:35) Oct 2, 2015, 03:37 PM ET
- Clemson holds off Notre Dame
- (02:50) Today, 12:10 AM ET
- Clemson, Notre Dame can both learn from matchup
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- (01:04) Yesterday, 10:33 PM ET
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- (00:47) Yesterday, 11:55 PM ET
- Greinke, Dodgers edge Padres
- (00:44) Yesterday, 11:39 PM ET


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text:
The Call
Goldman Sachs Changes 70 People's Lives
The following employees successfully made it through the "vigorous cross-ruffing" process and were inducted into the Brotherhood of the Sach this morning.
A Third Group Will Lay In Wait For Twenty Or So Years Before Bulldozing The House Of The Guy Who Did This To Them
The phone call lasts just a few seconds. The words "congratulations, you've become a partner," […]
High-Frequency Monitoring: A Short-Sighted Behavior
The more frequently you monitor your portfolio, the more likely you are to observe a loss.
This is likely to cause short-sighted decisions and could hurt your investment performance.
If you are checking your portfolio more than once per quarter, you're doing it too much.
Click to read more.
Dan Egan, Betterment Director of Behavioral Finance and Investing
Effective today, the contents of her desk suggest.
Larry Kudlow Caught In The Middle Of Awkward Game Of Mammary Musical Chairs
As you may or may not have heard, Melissa Francis is due back on The […]