text:
The 2014 Union County Fair is less than two weeks away and while many of the events are familiar to the community, some newer additions have not received as much publicity. Perhaps the best example is the Union County Fair Stock Dog Trial, which starts at 8 a.m. July 12 and 13. This is partly […]
County fair, two weeks away, adds more events
Cochran wins county, state in senate nomination run-off
Incumbent Republican Senator Thad Cochran narrowly won the nomination toward a seventh term Tuesday, coming back after being outvoted by Tea Party challenger Chris McDaniel in the June 3 party primary. Preliminary totals Tuesday had Cochran with 50.8 percent of the vote to McDaniel's 49.2 percent – a difference of only about 6,400 votes statewide. […]
University of Mississippi honor rolls
Undergraduate students who earn a semester GPA of 3.50-3.74 will be listed on the Dean's Honor Roll; those who earn a semester GPA of 3.75-4.00 will be listed on the Chancellor's Honor Roll. To be eligible for honor roll designation, a student must have completed at least 12 graded hours for the semester and may […]
Mayor reported doing well after freak accident
New Albany Mayor Tim Kent was reported recuperating at home and possibly will be allowed to return to work next week. The monthly meeting of the board of aldermen will be Tuesday. Kent was airlifted to North Mississippi Medical Center Tuesday night, June 17, where he underwent emergency surgery following a freak accident. He was […]
July Things To Do
By Angie Barmer Now that July is here, there is a whole month of activities for kids to be involved in around town. From 8:30 a.m. to noon, July 7-11,children ages 6-12 will be participating in Healthy Kids Camp at the Baptist HealthPlex. Children will learn about swimming, nutrition, first aid, fire safety, and there […]
County jobless rate up slightly but still among lowest
Union County's unemployment rate was up one percentage point from April to May, but still managed to rank second-lowest in Northeast Mississippi and third statewide. According to figures from the Mississippi Employment Security Commission, Union County had 6.5 percent of its workforce without Jobs in May compared to 5.5 percent the previous month. The local […]
A sense of relief
The Republican primary is finally over, and for many Mississippians it brings a sense of relief. Relief from the bitter and often unpleasant political commercials that inundated our airwaves, mostly paid for by groups from who knows where with innocuous names, but not innocuous agendas. But also, for many of us, relief in knowing that […]
County board having to take look at system for care of mentally ill
The Union County Board of Supervisors is once again having to decide the question of how to handle mentally ill residents. They learned Monday that a system that they thought has been working well for nearly three years may be discontinued due to lack of sufficient funding. For many years, when someone believed another to […]
July 4 closings, solid-waste and deadline changes include Gazette
Most businesses, including the New Albany Gazette, and all governmental offices will close Friday, July 4, in observance of Independence Day. Because the holiday is on a Friday, the publication schedule for the Gazette will change as well. For the Wednesday, July 2, issue, the ad deadline will be 5 p.m. Thursday, June 26 and […]
Circuit court terms ends with more sentences
The second week of the June term of circuit court ended Friday with about two dozen cases being handled in addition to those reported this past week. Many of the cases came out of indictments returned by the Union County grand jury in April, a large percentage of which were drug-related. Judge John Gregory heard […]
- Lady Urchins drop Mooreville from unbeaten ranks October 3, 2015
- Not your father's phone company October 7, 2015
- Honoring Vance Witt October 7, 2015
- Lady Urchins sweep and finish perfect in division October 8, 2015
- Urchins travel to Mantachie for key division contest October 8, 2015
- Friday Night Lights: Bulldogs route Byhalia for first division win October 10, 2015
- Community Health Fair October 9, 2015
- Aldermen act to restrict limit downtown parking, yard sales October 9, 2015
- Aldermen act on several items but subdivision, sign, metal siding ordinances still not settled October 9, 2015
- Hospital 'Tree of Love' offers opportunity to honor others and help patients October 9, 2015
- guest: "Being vaccinated does not guarantee you will not...
- Ward Johnson: I saw your article in the Eau Claire Leader-Telegr...
- The Ghost of Col. Reb: I would be more concerned about getting the best, ...
- The Ghost of Col. Reb: This is awesome! What a great way to save money, t...
- Bradley: I think that this is great news. Students will hav...
Local Resources
Visit New Albany
New Albany Main Street Association
New Albany Schools
Union County Development Association
Union County Library
Union County Heritage Museum
Tanglefoot Trail
Divorce Lawyer
Mayfield Law Firm
Social Security Disability Lawyer
Bankruptcy Lawyer
Auto Accidents Lawyer
Tupelo Lawyer
Thames Family Dentistry
Nettleton Dentist
Subscribe to Blog via Email
Recent Posts
- Friday Night Lights: Bulldogs route Byhalia for first division win
- Community Health Fair
- Aldermen act to restrict limit downtown parking, yard sales
- Aldermen act on several items but subdivision, sign, metal siding ordinances still not settled
- Hospital 'Tree of Love' offers opportunity to honor others and help patients
Recent Comments
- guest on Flu shots expected to be more effective this year but adults may need other vaccinations as well
- Ward Johnson on Pre-K students at elementary school learn about butterflies
- The Ghost of Col. Reb on Election commission disqualifies Browning from education superintendent's race
- The Ghost of Col. Reb on New Albany High on way to becoming state's first all-iPad school
- Bradley on NAHS students get to pick up iPads next week


text:
Chef Sanjeev Kapoor's Licensing and Merchandising vertical foresees INR 100 crore business in next 5 years
Mumbai: Renowned Brand Sanjeev Kapoor, at the recent HGH India 2015 annual trade held at the Bombay Convention and Exhibition Centre, announced the launch of Sanjeev Kapoor branded Table and Kitchen Linen and Cutlery products. This marks the foray of Brand Sanjeev Kapoor into the lifestyle houseware and kitchenware segment through Brand licensing deals. Chef Sanjeev Kapoor plans to bring-in premium products ...Read more ›

subset: commoncrawl


text:
Nature's Variety Instinct Raw Boost Minis Duck Formula Freeze-Dried Dog Treats, 3.25-oz bag
|List Price:
|$7.99 & FREE 1-2 Day Shipping at $49
|You Save:
|$4.10 (34%)
Select Autoship at checkout and get this item for $7.59 (save 5%)
In Stock
Product Description
Treat your dog to the wholesome goodness he deserves with Instinct Raw Boost Minis. Healthy and delicious, Raw Boost treats give dogs what they crave, including real all-natural duck, turkey and pure raw ingredients. These low calorie freeze dried treats are the perfect way to provide your dog with the healthy benefits of raw in a delicious flavor he'll absolutely love.
Key Benefits
- 100% freeze dried raw ingredients including real duck, turkey, carrots and apples
- Great taste and health benefits
- All-natural with no artificial colors, flavors or preservatives
- Grain-free and gluten-free
- No corn, wheat, soy or fillers
- Only two calories per piece
- Perfect reward or training treat
- Made in the USA
|Item Number
|Food Form
|Breed Size
|Country of Origin
|Special Diet
Pet lovers who bought this item also bought...
Important Information
Duck (including ground duck bone), turkey, turkey liver, turkey heart, pumpkinseeds, apples, carrots, butternut squash, ground flaxseed, montmorillonite clay, broccoli, lettuce, spinach, dried kelp, apple cider vinegar, parsley, honey, salmon oil, mixed tocopherols, olive oil, rosemary extract, blueberries, alfalfa sprouts, persimmons, inulin, rosemary, sage, clove
Customer Ratings & Reviews
Rated 4.8 out of 5 by 35 reviewers.
Rated 5 out of 5 by RedVelvetLynx This Must Be Good Stuff My basenjis will potty in the rain for these treats! June 19, 2013
Rated 3 out of 5 by Jbfann Really, really small! Nice natural freeze denied raw treats, but I have Cavaliers and these are just about too small for even them. January 11, 2014
Rated 5 out of 5 by Nell1976 Yummy! (my four chihuahuas say so!) These are freeze dried, small,light, and PERFECT for a little delicious treat! My 4 little chihuahuas will dance, jump up and down, and go around in circles when they hear me reaching for the cupboard and package. For me, they are a HIT! June 13, 2015
Rated 5 out of 5 by Minksosoft Love these Love these treats. I got them for my cat because the dog size is larger but the ingredients are the same. My cat really likes them and the enzymes and salmon oil make his fur so incredibly soft. His digestion has also been 100% improved since I switched him over to instinct raw boost and Orijen six fish. There aren't a lot of chicken or duck foods that he will eat but these are a win because the salmon oil gets them past his smell test. February 8, 2014
Rated 5 out of 5 by poodle1 Low calorie & flavorful natural treat My dog is on a low calorie low fat diet. Nature's Variety Raw Boost Minis Duck Formula Freeze-Dried Treats satisfy him without him getting lots of calories & fat. June 27, 2014
Rated 5 out of 5 by towncountry Great for training My dogs and I love these threats. Specially the duck flavor. My youngest did two training classes and the minis were just perfect. It's a pure and healthy product and you can use a lot per class without worrying about upsetting your dog stomach. June 15, 2014
Rated 5 out of 5 by Bugsy Treats are just ducky! My dog loves these treats. They're pretty tiny for my Doberman, but the ingredients are so good I don't mind giving her several. I like the idea of giving a different protein as a treat than what she would normally eat at her meals. May 19, 2014
Rated 5 out of 5 by Pickycat1 love this! All kids (cats & dog) love these! Great to be able to give them ALL a treat! September 26, 2015


text:
2 Parks near Gladstone, Michigan
Escanaba, Michigan 7.35 miles SW
Rapid River, Michigan 7.89 miles NE
Harris, Michigan 17.63 miles SW
Garden, Michigan 23.4 miles SE
Gladstone, Michigan (map) | (906) 428-1211
Sites: 62 | Latest Rate: $30.00 | 21 Reviews
|Clean Restrooms:
|Clean Showers:
Sep 2015 - $30.00
This is a beautiful campground on the shore of a bay off Lake Michigan. Pull-through sites are long and level. We've been here before and loved it. People are nice. Showers are large and clean. We took a nice walk along the paved trail along the bay and caught up on our reading. If you like to watch tv though, you'd better have a satellite dish because they don't have cable and there are only a couple of over-the-air channels. - mrpeepers
Sep 2015 - $30.00
We debated about driving this far from Racine, but we are really glad we did. Access road is paved as are the interior roads. The pads are gravel, with some grass at the ends of the drive through sites. Beautiful tent sites. Walking/bike trail runs along front of the campground and along the lake. Some trees, but still could get satellite service without a problem. Good utilities. Lots of open areas with beautiful trimmed grass. Couple of sandy beaches leading out into the lake. Clean. This is a gem. Never saw the camp host. Note, do not take site 21 if you are a motorhome or a long 5er. The problem is a light pole at the entry to the site. Other drive thru sites seem to be okay. Some comments complain about getting to the park thru a residential area. From the south, take a right on Lakeshore Drive and follow it to the end, where it turns north and becomes 9th street. Go up the road to Michigan ave, and take a right on Michigan. Keep going and you will drive thru the gate. Simple access. There is a map posted by the rest rooms. Find your site and get settled. Check out is at noon. This place is a real treat. - okdiver
Aug 2015 - $30.00
Great RV park in a great location. Fair amount of shade and always a great breeze coming off Lake Michigan/Green Bay. Sites are smallish (narrow) but adequate. Hookups in good location and water, electric, and wifi was good. There is no cable even though the website and their own brochures still state there is. RV park roads are easy to navigate and are paved, site pads are gravel. Great views of the bay. Park is on east end of Gladstone and you have to travel down residential streets to get to it. - Steve & Nancy
Gladstone, Michigan (map) | (906) 786-1020
Sites: 75 | Latest Rate: $35.00 | 5 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2015 - $35.00
Somewhat noisy and lacking any privacy from trees. No recycling. Well patrolled. - Upriver
Jun 2015 - $28.00
It is easy on/off M35. While park lacks sewer and cable it makes up for with a park setting and no road noise. We requested a pull thru site close to the office for good Wifi and I have to say this is the best Wifi connection in all the parks we have stayed at. There are a few rigs that appeared to be there for a while but the park is clean and a great place to walk pets. There is also a free disc golf course on the property along with a playground. The sites are spaced apart so there is no problem opening slides etc..We would stay here again. - petpeople
Jun 2013 - $32.00
The girls at check in are friendly and the campground is large. - possumtrotky


text:
Principles of Pulmonary Medicine
- Steven Weinberger, MD, FACP, Executive Vice President and Chief Executive Officer, American College of Physicians; Adjunct Professor of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Senior Lecturer on Medicine, Harvard Medical School, Boston, Massachusetts
- Barbara Cockrill, MD, Pulmonary Vascular Disease Center, Brigham and Women's Hospital; Assistant Professor of Medicine, Harvard Medical School, Boston, Massachusetts
- Jess Mandel, MD, FACP, Professor of Medicine, Associate Dean for Undergraduate Medical Education, University of California San Diego School of Medicine, La Jolla, California
Concise and easy to read, this completely updated new edition correlates basic pathophysiologic principles with the radiologic, pathologic, and clinical aspects of disease to provide an integrated, user-friendly approach to the study of pulmonary medicine. In addition to detailed text, case-based questions cover topics including interpretation of pulmonary function tests, physiologic data, and results of arterial blood gas testing. More than 120 high-quality images complement the discussion of specific diseases and provide a clear framework for understanding difficult pulmonary concepts. The text provides updated coverage of diagnostic modalities in pulmonary disease, as well as management of asthma, lung cancer, respiratory failure, pulmonary hypertension, and other important pulmonary diseases. A new, web-based interactive learning tool box offers additional radiographic images, audio clips of lung sounds, and self-assessment questions modeled after the questions found on the USMLE exams. In print and online, this is an essential resource for mastering the foundations of pulmonary medicine.View full description
Respiratory Medicine, Sleep Medicine, Pulmonary Medicine, Internal Medicine, Medical Students
Book information
- Published: June 2008
- Imprint: SAUNDERS
Table of Contents1. Pulmonary Anatomy and Physiology—The Basics
2. Presentation of the Patient with Pulmonary Disease
3. Evaluation of the Patient with Pulmonary Disease
4. Anatomic and Physiologic Aspects of Airways
5. Asthma
6. Chronic Obstructive Pulmonary Disease
7. Miscellaneous Airway Diseases
8. Anatomic and Physiologic Aspects of the Pulmonary Parenchyma
9. Overview of the Diffuse Parenchymal Lung Diseases
10. Diffuse Parenchymal Lung Diseases Associated with Known Etiologic Agents
11. Diffuse Parenchymal Lung Diseases of Unknown Etiology
12. Anatomic and Physiologic Aspects of the Pulmonary Vasculature
13. Pulmonary Embolism
14. Pulmonary Hypertension
15. Pleural Disease
16. Mediastinal Disease
17. Anatomic and Physiologic Aspects of Neural, Muscular, and Chest Wall Interactions with the Lungs
18. Disorders of Ventilatory Control
19. Disorders of the Respiratory Pump
20. Lung Cancer: Etiologic and Pathologic Aspects
21. Lung Cancer: Clinical Aspects
22. Lung Defense Mechanisms
23. Pneumonia
24. Tuberculosis and Nontuberculous Mycobacteria
25. Miscellaneous Infections Due to Fungi and Pneumocystis
26. Acquired Immunodeficiency Syndrome
27. Classification and Pathophysiologic Aspects of Respiratory Failure
28. Acute Respiratory Distress Syndrome
29. Management of Respiratory Failure
Appendix A
Appendix B
Appendix C


text:
Hours Of Operation
Edwards Chevrolet of Storm Lake - Serving Sioux City Buick, GMC and Chevrolet Customers
Welcome to Edwards Chevrolet of Storm Lake. We're glad you chose to stop by and check out what we can do for you. Since 1959 we've been a cornerstone to the community of Storm Lake. Our attention to our customers is what has allowed us to be here for this long and we look forward to another 50 years listening to our customers! Our reputation has preceded us to as far away as Fort Dodge and the rest of Northwestern Sioux City, too. No matter what you're looking for, we have the car or truck you need. We invite Fort Dodge Chevrolet, Buick & GMC customers to our dealership in Storm Lake, IA. We proudly serve Fort Dodge Chevrolet, Buick and GMC customers. We have a huge inventory of GM vehicles for Sioux City Buick, Chevrolet and GMC customers.
Buick is well known for its mid-range luxury status. Driving a Buick is both comfortable and exhilarating. If you're in the market for a Buick, then you need to test-drive the Buick Regal. This is not your parent's Buick! While it's spacious interior is enough for five adults, it's the modern amenities, like OnStar and BlueTooth connectivity that'll get you hooked. Pre-qualifying for a car loan is easy because Buick is so affordable! Whether you've compared us to Fort Dodge Buick dealers or other Sioux City dealers, the service you get from our Storm Lake dealership is like no other. Fort Dodge Buick, GMC and Chevrolet drivers rely on our dealership for all their vehicle needs. We are glad to serve Sioux City Chevrolet, Buick and GMC customers.
Fort Dodge and Sioux City Buick & GMC Dealer Alternative in Storm Lake
From the luxury of Buick to the versatility of Chevy, we have the right car for you. Check out the Chevy Cruze and consider it for your next commuter car! It practically sips gas! But Chevrolet is known for more than just its cars. The Silverado is one of the most popular trucks on the road today. And for good reason! It's powerful, comfortable, and reliably built. If you're browsing Fort Dodge Chevrolet dealerships, don't buy until you visit Edwards Chevrolet of Storm Lake. Fort Dodge GMC, Chevrolet & Buick drivers, schedule an appointment today!
Fort Dodge Chevrolet, Buick and GMC Source in Storm Lake
Where Chevy has versatility, GMC has solid construction. GMC trucks and SUVs have lead the industry in what it means to be a truck or SUV. See what we mean by sitting in a GMC Yukon! Spacious and filled with all the modern features you've come to expect from a GMC SUV, the Yukon is also powerful enough to haul a boat or camper. We invite all Fort Dodge GMC drivers to check out all that we have to offer at Edwards Chevrolet of Storm Lake.
GMC Trucks and SUVs For Fort Dodge Chevrolet Drivers
As you can see, Edwards Chevrolet of Storm Lake has what you're after no matter what it might be. But eventually, even your new car or truck will need maintenance. We have you covered there, too! Visit us when you need an oil change or tire rotation. We'll give your vehicle a thorough diagnostic exam and make sure there's nothing else that needs to be taken care of while we're at it. We realize there are many car dealerships near Sioux City, but no one can be the quality service at Edwards Chevrolet of Storm Lake! Schedule your service appointment online or call us at (877) 267-0187 when you're ready. If you don't remember when you last had your oil checked, please call us right away! We are your premier Fort Dodge Chevrolet, GMC & Buick dealer alternative in Storm Lake, IA. We also provide financing options to Sioux City GMC, Buick and Chevrolet shoppers.
GM Service and Parts in Storm Lake, IA
Chevrolet: Camaro | Colorado | Cruze | Equinox | Impala | Malibu | Silverado 1500 | Sonic | Spark | Tahoe | Traverse | Volt
Buick: Enclave | Encore | LaCrosse | Verano
GMC: Acadia | Sierra 1500 | Terrain | Yukon


text:
Chuck E. Cheese's has introduced Skate Universe, an app that lets gamers help the brand's mouse mascot dodge obstacles at various skate parks. It is now available for free download on iOS and Android devices, and players can win points for in-store ticket redemption.
"Skate Universe is just one piece of a long-term strategy to bring together the best family entertainment anywhere with the technology today's parents and kids want," President Roger Cardinale said in a news release. "It's the next example of our dedication to using technology to further enhance our customer's experience and relationship with Chuck E. Cheese's."
Skate Universe features two skate parks, a jungle theme and candy theme, through which users help Chuck E. navigate and avoid obstacles. Along the way, they collect treasures and multipliers, which enhance Chuck E.'s skate gear and speed, plus points that can earn tickets.
Players can earn up to 50 tickets per skate park and up to 100 tickets by completing both skate parks. Players can win up to 1,000 tickets to redeem in-store.
Tickets earned can be printed via email coupon to the parent or account holder and are redeemable at Chuck E. Cheese's locations for tangible prizes, the release said.
Topics: Chuck E. Cheese's Pizza , Customer Service / Experience , Online / Mobile / Social
Sponsored Links:
Papa John's introduces XL Monster Toppings pizza
Toppers Pizza going 'back to the future'
Let's Pizza vending machine ready for U.S. debut
Unique toppings: Do they work only as LTOs?
Are you following the 12 dos and don'ts of restaurant financing?
LIVE WEBINAR - Restaurant Tech 2020: What you need to know NOW to be ready
Pizzeria Planning: Designing and Maintaining an Efficient Pizza Kitchen
Pizza Point of Sale | Right the First Time
LIVE WEBINAR - Restaurant Tech 2020: What you need to know NOW to be ready
Pizza Point of Sale | Right the First Time
6 Steps to Help You Choose the POS Software that Best Suits Your Business
WEBINAR: Managing customer relationships - what Which Wich learned on its search for the perfect CRM


text:
Victoria Beckham Denim's flared mid-rise jeans are perfect - the dark-blue hue is super flattering and the stretch finish offers a comfortable and flexible fit. Maximize the silhouette with heels.
Dark-blue stretch-denimBelt loops, five pocketsButton and zip fastenings at front98% cotton, 2% elastaneMachine wash inside out to avoid color transfer
Product code: 377795 - Need help? Contact us


text:
Someone Finally Mashed Up Kanye With Weezer and Made Yeezer
This was inevitable.By Dee Lockett
This was inevitable.By Dee Lockett
It's a Canadian goth R&B French-electronica meet-cute.By Devon Ivie
Introducing WHATN-E, the robot botanist.By Sean Fitz-Gerald
Our latest Vulture Remix!By Ezequiel López
Darth Punk.By Sean Fitz-Gerald
It's our latest "Vulture Remix."By Louis Plamondon
The latest Vulture Remix.By Adam Schleichkorn
The latest "Vulture Remix" addresses all your muscle-car needs.By Abraham Riesman
Little voices, big noises.By Sean Fitz-Gerald
The first episode in our new "Vulture Remix" series!By Louis Plamondon and Abraham Riesman
The Avengers of Oz: Age of Tin Man marries the superhero epic with the classic fantasy film.By Greg Cwik
They're back!By Dee Lockett
It's a miracle!By Nate Jones
With Steve from corporate, too!By Nate Jones
So many tears.By Dee Lockett
Get it? There are so many clones.By Lindsey Weber and Linsey Fields
Thanks, rhyming!By Jesse David Fox
Bet he would've had a much easier time spelling negus.By Dee Lockett
Coming soon to VHS!By Louis Plamondon and Abraham Riesman
Rotoscoping FTW.By Sean Fitz-Gerald


text:
After reading the 2 bad reviews below, I almost passed up this place, thankfully I didn't. I called and received an appt the same day and was in and out as fast as any vet that I've been to.\r
I normally don't take the time to write reviews like this but because of the negative remarks I had to defend this clinic.\r
I asked the front office staff if they knew about these negative reviews and they said it w... view more
Pacific Beach Veterinary Clinic
Today:7:00 am - 6:00 pm
1362 Garnet Ave,
San Diego, CA 92109
(858) 272-6255
Business Details
- Hours:
Regular Hours
- Extra Phones:
Phone: (858) 270-5160
Phone: (858) 869-0135
- Services/Products:
- Emergency Services
- Exotic Animals
- Small Animals
- Payment method:
- amex, discover, master card, visa, cash, check, debit
- Neighborhoods:
- Pacific Beach, Northern San Diego
Pacific Beach Veterinary Clnc
Pacific Beach Vet Clinic
- Other Link:
- Categories:
- Veterinarian Emergency Services, Veterinarians, Veterinary Clinics & Hospitals
After reading the 2 bad reviews below, I almost passed up this place, thankfully I didn't. I called and received an appt the same day and was in and out as fast as any vet that I've been to.\r
I've been taking my animals to PB Vet for Lord knows how many years. At least 30 years, I'm sure. I've never had a complaint about the service, cost, or care in that whole time. Yes, sometimes I gulp at the cost but it's not because they were over-priced. Sometimes animals are worse than kids and it's going to cost!
I currently have three dogs and two cats. I'm sure the excellent care my "babies" get at ... view more
I called and asked to speak to the Dr. who was helping us with our dog. She said she wasn't available and hung up on me. I couldn't believe it ... so I called back and asked her if she hung up on me and she said ""yes"" ! The receptionist was off the chart rude and finally took my name and #. While the Dr was very nice she didn't quote us and then stuck us with a $450.00 bill. I would not recommend this Vet in any wa... view moreLike this review?Yes|Flag AbuseProvided by Citysearch
the service was very atttentive and extremely personal. Everyone was so nice and compassionate even when I almost fainted when I saw the bill!!thanks for #1care I would recommend you guys to everybody!!!Like this review?Yes|Flag Abuse
After spending an obscene amount of money for a treatment plan that failed miserably, I brought her in one last time to just ask for the correct medicine (I have seen a specialist out of state for this condition and was instructed to keep her on this med if she ever got sick again). They made me wait almost and hour and then when a different vet finally offered to see me, I got about 5 minutes of her time and basica... view moreLike this review?Yes|Flag AbuseProvided by Citysearch


text:
The Pope addressing the masses
Every time they try and deny it more and mroe evidence emerges....
402 members366 Comments 8 Likes
26 members30 Comments 1 Like
136 members24 Comments 0 Likes
439 members89 Comments 6 Likes
107 members45 Comments 2 Likes
Welsh Andy has not received any gifts yet
© 2015 Atheist Nexus. All rights reserved. Admin: Richard Haynes.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jun 30, 1998
|Filing date
|Jan 26, 1996
|Priority date
|Mar 13, 1991
|Fee status
|Also published as
|Publication number
|Lewis T. Polk, Jr., Hugh Vartanian, Phillip P. Brown, Walker M. Sloan III
|Original Assignee
|Cytyc Corporation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (20), Non-Patent Citations (6), Referenced by (21), Classifications (39), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a divisional application of Ser. No. 08/285,416 filed on Aug. 3, 1994, U.S. Pat. No. 5,503,802 which is a continuation of application Ser. No. 07/843,571, filed Feb. 28, 1992, U.S. Pat. No. 5,364,597, which is a continuation-in-part of the commonly assigned application Ser. No. 07/668,892, filed Mar. 13, 1991 abandoned.
This invention relates to a device for collecting microscopic particles, such as cells, from a fluid medium and for transferring the collected cells to a receiver, such as a glass microscope slide. The device collects the cells with a desired spatial distribution, and enables the cells to be transferred to the receiver with that same spatial distribution.
A collection and transfer device according to the invention is useful in the performance of cytological procedures. In a typical cytological procedure, cells are collected from a liquid containing sample cells to be examined, and are transferred onto a microscope slide or other receiver for viewing and evaluation.
Cytological examination typically requires that the cells on the microscope slide be in a single layer and be separated from one another, i.e. dispersed. In some practices, the cells are counted, so that a generally known quantity of the cells is examined.
One prior device for collecting a dispersed monolayer of cells, and for transferring them to a microscope slide for examination, has a surface-collecting filter spanning an end of a tube. To collect cells, that end of the tube is immersed in a liquid that contains cells to be examined. A vacuum is applied to the tube to aspirate liquid through the filter. This flow of aspirated liquid into the tube deposits cells on the outer side of the filter. Each cell on the filter obstructs further flow of liquid through the filter, and therefore the cells collect on the filter with a generally dispersed and single layer spatial distribution. The filter is subsequently placed against the microscope slide to transfer the collected cells to the slide with that same spatial distribution. A slight fluid pressure is preferably applied to the inner side of the filter to facilitate this transfer of the cells to the slide. The transfer process, in effect, "prints" the particles collected on the filter onto the viewing slide. Also, it generally is desired to use the filter device only once and then discard it, to avoid inter-sample contamination. Accordingly, it is desired that the filter device be suited for high volume manufacture at relatively low cost.
The pending and commonly assigned U.S. patent application Ser. No. 487,637 for "METHOD AND APPARATUS FOR CONTROLLED INSTRUMENTATION OF PARTICLES WITH A FILTER DEVICE" discloses a filter device of the above character for collecting cells from a sample liquid and with a desired spatial distribution. That application for patent, and the pending and commonly assigned U.S. patent application Ser. No. 550,142 for "METHOD AND APPARATUS FOR PREPARING CELLS FOR EXAMINATION," disclose apparatus and procedures for performing cell collection with the filter device and for transferring the collected cells to a microscope slide with the desired dispersed spatial distribution. The disclosures of both of these pending applications for patent, which use the terminology "screen filter" to designate a surface-collecting filter, are incorporated herein by this reference.
It has been found that not all the cells collected with the known filter device of the type described above transfer to the viewing slide. Instead, different ones of the filter devices transfer different portions of the collected cells. This loss of cells is undesirable, and the variations in the portion of cells that are transferred is also undesirable. The loss of transferred cells reduces the number of cells available for inspection and it can result in a generally unknown quantity of cells being transferred to the glass slide.
It accordingly is an object of this invention to provide a device for the collection of cells and like particles from a fluid medium with a dispersed spatial distribution and for the transfer of the collected particles to a glass slide or like receiver with minimal loss of particles. It is also an object that the device facilitate transfer of the particles with faithful retention of the spatial distribution of the collected particles.
A further object is to provide a structure and manufacture for such a device so that different devices provide a consistent and uniform transfer of collected particles to the receiver.
The objects of the invention also include providing a particle collection and transfer device that can be placed automatically in a specified orientation and location, relative to lineal and rotational axis; and that can couple releasably and replaceably with fluid conduits.
Another object of the invention is to provide a particle collecting and transferring device of the above character that can be manufactured at relatively low cost. It is a corresponding object to provide a method for manufacturing such a device that can be practiced at relatively low cost.
Other objects of the invention will in part be obvious and will in part appear hereinafter.
A particle collecting and transferring device according to the invention can be used to transfer essentially all collected cells to a glass slide or other receiver, with faithful replication of the spatial distribution of the cells as collected. The device attains these objectives by disposing a filter of the surface-collecting type on a support body with a highly planar geometry. The filter collects the particles of interest on its outer surface. The planar disposition of the filter enables it to contact the receiver, such as a microscope slide, completely and uniformly, so that a consistent and high percentage of the collected particles transfer to the receiver. Further, the transferred particles have the same spatial distribution as they had on the filter prior to the transfer.
The invention stems from the finding that the prior structure and manufacture of the known filter device provided a surface-collecting filter that was not entirely flat, and from the finding that different ones of the device have filters that exhibit varying departures from flatness.
The invention thus provides a new structure for a device that collects particles such as cells from a fluid sample. The new structure enables the particle collecting device to transfer essentially all the collected particles to a microscope slide, and with a substantially exact replication of the spatial distribution that the cells had when on the collection device.
One embodiment of the new structure supports a sheet-like filter sheet, e.g. a pore membrane filter, on a planar tubular rim located at the end of a support body. The filter has a precise degree of flatness defined by the tubular rim. The new structure fastens the filter sheet to the support body at an annular surface recessed inwardly on the body below the rim. This new structure allows the filter to be attached to the support body with a low cost bonding technique, examples of which include thermal bonding, ultrasonic welding, and solvent bonding. Distortions of the mounting structure caused by the bonding technique are confined to the mounting surface, and do not detract from the desired precision flatness of the filter-positioning rim.
A preferred optional feature of the filter device is the provision of a barrier between the filter positioning rim and the mounting surface. The barrier retards a bonding effect, such as heat, that is developed in the bonding process from disturbing the rim, where it might cause undesired geometrical distortion. The barrier can also be configured to receive excess or dislodged material produced during the bonding procedure, so that such material does not detract from the precision disposition of the filter on the rim. One embodiment of such a barrier structure is an annular trough on the support body located between the positioning rim and the mounting surface. The trough is geometrically disposed to have a depth dimension that increases the conduction path length between heat generated at the mounting surface and the positioning rim.
It is accordingly one feature of the invention to provide a particle collecting and transferring device that has a planar surface-collecting filter on a support body. The support body preferably is a tubular body that mounts the filter on a planar rim at one end. The body has an annular mounting surface disposed radially outward of the rim and axially inward on the body from the rim. The mounting surface preferably is generally parallel to the rim.
A further feature of the apparatus is a surface-collecting type filter having a first portion spanning the tubular body and seated on the rim for disposition in the plane defined by the rim. The filter first portion thus has an outer surface, facing outwardly from the tubular body, on which microscopic particles carried in a fluid can be collected, and from which such collected particles can be transferred to a receiver such as a microscope slide. The receiver is brought into abutment with the particle-carrying outer surface of the filter first portion to effect that transfer of the collected particles.
The features of the collecting and transferring device further include a mounting portion of the filter peripheral to the first portion and that is secured to the annular mounting surface, and thereby attached to the support body.
The structure for securing the mounting portion of the filter preferably includes a bond, between the material of the tubular body and the material of the filter. That bond typically is a substantially solid bonding flow of material produced with a technique such as ultrasonic welding, thermal bonding, or solvent bonding.
It is also a feature of the collecting and transferring device to provide a distortion barrier between the planar rim and the mounting surface. The barrier isolates the rim from material-distorting action developed during the attachment of the filter to the mounting surface. The barrier in a preferred embodiment is formed by an annular trough on the housing body and disposed between the rim and the mounting surface and having a depth dimension extending longitudinal to the axis of the tubular body.
In one embodiment, the new structure features a tubular support body having opposed axial ends, a first of which is open and a second of which is closed. A planar rim as described above is disposed at the open axial end for supporting a filter element in a planar orientation. An annular mounting surface is located on the periphery of the tubular support body between the axial ends for receiving a portion of the filter element to secure the filter element to the tubular support body.
An advantageous feature of this embodiment of the invention is that a fluid coupling element is provided, between the axial ends, for effecting a removable and replaceable connection to a pressure control source. This allows the particle suspending fluid to be drawn through the filter element, into the tubular support body, to trap particles against the outer surface of the filter element. Orienting means are provided for orienting the coupling means for alignment with the pressure control source connection.
A benefit derived from this embodiment of the invention is improved intra-sample isolation of the particle processing instrument with which the new particle collecting and transferring device is used. That is, because one axial end of the tubular support body is closed, particle suspending fluid drawn into the body, i.e., filtrate, does not come into contact with the particle processing instrument. Moreover, after the collected cells are transferred from the surface-collecting filter element the filtrate can be blown back through the filter element out of the tubular support body. Due to this feature of the invention the particle processing instrument with which the new particle collecting and transferring device is used does not need to have a waste disposal circuit.
The foregoing and further features of the invention attain a highly planar surface-collecting filter for the collection of particles from a fluid and for the precise uniform abutment with a microscope slide or other receiver, so that a consistent and maximal portion of the collected particles can readily be transferred to that receiver, and with a maximal retention of the spatial distribution that the particles had on the filter.
Further, the device can be manufactured at relatively low cost and in high volume. This is desirable to enable a fresh device to be used with each cytological sample being processed, and thereby to avoid intersample contamination.
One preferred method of manufacture thermally bonds the membrane filter to the annular mounting surface of the tubular body. A preferred thermal bonding operation employs a heated tool that presses the filter membrane against the annular mounting surface, which is thermoplastic, and melts the mounting surface sufficiently to embed the filter membrane. Upon cooling, the thermoplastic material of the mounting surface provides a secure mechanical bond of the filter membrane to the tubular body.
It is also preferred that the membrane filter be sufficiently taut to be free of wrinkles or puckers, and to have effectively no sag. The membrane material can be stretched to have this desired tautness concurrent with or subsequent to the bonding to the support body. A further preferred practice according to the invention is to employ a heat-shrinkable material for the membrane filter, and to subject it to sufficient heat to shrink it to attain the desired degree of stretch. Preferred materials for manufacture with a successive thermal bonding step and a subsequent heat shrink are to use a polycarbonate filter and a tubular body formed of polystyrene.
The invention accordingly comprises the features of construction, combinations of elements and arrangements of parts exemplified in the constructions hereinafter set forth, and comprises the several steps and their relation of one or more of such steps with respect to each of the others for fabricating such a structure, all as exemplified in the following detailed disclosure, and the scope of the invention is indicated in the claims.
For a full understanding of the nature and objects of the invention, reference is to be made to the following detailed description and the accompanying drawings, in which
FIG. 1 is a perspective view of one embodiment of a collection and transfer device according to the invention;
FIG. 2 is a side elevation view, partly in section, of the device of FIG. 1;
FIG. 3 is an enlarged fragmentary detail of FIG. 2, without the viewing slide;
FIG. 4 is a fragmentary side elevation view, partly in section of another collection and transfer device according to the invention;
FIG. 5 is a perspective view of still another embodiment of a collection and transfer device according to the invention;
FIG. 5A is a cross-sectional view taken along line A--A of a portion of another embodiment of the device shown in FIG. 5;
FIG. 6 is a cross-sectional view taken along line 6--6 of FIG. 5;
FIG. 7 is a cross-sectional view taken along line 7--7 of FIG. 6;
FIG. 8 is a schematic representation of an instrument that operates with the device of FIG. 5; and
FIGS. 9 and 10 are schematic showings of a process for fabricating a device according to further features of the invention with successive thermal bonding and heat-shrink operations.
FIGS. 1 and 2 show a particle collecting and transfer device 10 according to the invention with a surface-collecting filter 12 mounted on a tubular body 14. The illustrated filter is a known pore membrane structure. A rim 16 at one end of the body 14 positions a central portion 12a of the filter in a flat configuration, i.e. planar, and the filter is secured at a peripheral portion 12b to a mounting surface 18 that is recessed inwardly on the body 14 from the rim 16.
The structure isolates the rim 16, so that it can position the filter with precision, from the location of the attachment of the filter to the body, i.e. from the mounting surface 18. Distortions of the mounting surface due to the mode of attachment thus do not alter the precise positioning geometry of the rim 16. As a result, the filter central portion 12A can have a precision planar disposition. When a glass microscope slide 22, shown in phantom in FIG. 2, is brought into contact with the filter central portion 12a, essentially the entire filter central portion abuts the microscope slide. This substantially uniform abutment enables collected particles located throughout the entire surface of the filter central portion to be transferred directly to the microscope slide. There is essentially no loss of particles remaining on the filter, and the particles transfer with the same spatial distribution that they had on the filter.
More particularly, the illustrated tubular body 14 has a cylindrical wall 24 extending along an axis 26. The positioning rim 16 is at one axial end of the inner surface of the cylindrical wall 24. The annular end face 28 of the cylindrical wall 24 at that axial end, of which the radially inner portion forms the positioning rim 16, is axially recessed at a location radially outward of the positioning rim 16 to form the mounting surface 18. The illustrated mounting surface 18 is thus an annular surface concentric with the annular positioning rim 16 and is axially spaced from the rim inwardly on the body 14.
As shown in FIGS. 1 and 2 and in detail in FIG. 3, a preferred yet generally optional structural feature of the device 10 is a barrier indicated generally at 30 on the body 14 and interposed between the positioning rim 16 and the mounting surface 18. The illustrated barrier 30 includes an annular trough 34 oriented so that the depth dimension extend longitudinal to the axial spacing between the rim 16 and the mounting surface 18. Correspondingly, the width of the illustrated barrier trough 34 extends in the radial direction, and is interposed radially between the rim 16, which is radially inward from the barrier, and the mounting surface 18, which is radially outward from the barrier.
The barrier 30 also includes the collar-like axially-extending wall 32 that extends on the body 14 between the positioning rim 16 and the mounting surface 18.
The barrier 30, and particularly the trough 34, present a long thermal conduction path that isolates any heat developed at the mounting surface 18, during attachment of the filter thereto, from distorting or otherwise geometrically altering the positioning rim 16. This long path also retards solvent action, when solvent bonding is used, from deforming the rim 16. Further, the void formed by the barrier trough 34 provides a receptacle for trapping and otherwise receiving debris and other excess or flowing material produced during the bonding or other attachment of the filter peripheral portion 12b to the mounting surface 18. The barrier 30 thus substantially isolates the positioning rim from distortion and from material debris that might otherwise alter or otherwise detract from the desired highly planar surface which the positioning rim defines.
Further structure of the illustrated device 10 includes, adjacent its other axial end, a seat 36 that seals removably and replaceably with a cover plate 38 fitted with a through conduit 40. The cover plate can fit with the cylindrical wall 24 of the seat 36 to provide a fluid tight seal closing that end of the tubular body 14, except for the aperture which the conduit 40 provides.
As also shown in FIGS. 1 and 2, the illustrated device 10 has an outwardly projecting mounting and drive hub 42 disposed adjacent the sealing end of the body 14. As described further in the co-pending applications for patent noted above, the device 10 can be mounted in an instrument by way of the positioning hub 42 and rotated by way of idler rollers that engage the hub 42. The device 10 can, in addition, be sealed closed in the instrument by way of the cover plate 38, with the only openings being by way of the conduit 40 and the filter central portion 12a. When the device is inverted from the position shown in FIGS. 1 and 2 and the lower, filter-carrying end is immersed in a liquid sample containing particles, a vacuum applied to the conduit 40 aspirates liquid into the interior of the tubular body 14 and, in the process, collects particles carried in the liquid onto the outer surface of the filter central portion 12a.
As further described in the noted co-pending applications for patent, the device 10 with particles on the outer surface of the filter central portion 12a, after removal from the particle containing liquid, can be placed in abutment with a microscope slide 22, as illustrated in FIG. 3. The cells or other particles collected on the filter are transferred to the glass slide. The transfer of particles from the filter to the microscope slide can be facilitated by applying an elevated pressure to the inner side of the filter portion 12a.
With further reference to FIGS. 1, 2, and 3, the filter 12 is secured to the tubular body 14 by way of attachment of the peripheral portion 12b to the mounting surface 18. A preferred attachment is obtained by heat staking the filter peripheral portion to the material of the tubular body at the mounting surface 18. As described below in greater detail, with this fabrication process after the filter 12 is positioned on the rim 16 of the cylindrical wall 24 of the tubular body 14, a heated ram is brought into selected pressure contact with the filter peripheral portion 12b, pressing it against the mounting surface 18. The heat radiated by the ram creates a bonding flow of material of the tubular body 14 that bonds the filter peripheral portion to the mounting surface. The resultant bond 44, FIG. 3, preferably is both mechanical and intermolecular, upon solidification of the flowed material.
Alternative techniques for securing the filter 12 to the mounting surface 18 include ultrasonic welding and solvent bonding. These techniques are generally known in the art.
With a preferred practice of the invention the cylindrical wall 24 of the tubular support body 14 is molded from polystyrene resin marketed by the Dow Chemical Company under the designation Styron 685D. The filter 12 is a polycarbonate membrane treated with a wetting agent, as commercially available from manufacturers to be hydrophilic, and heat staked to the tubular body 14 as described below. As mentioned, however, the filter 12 can also be ultrasonically bonded to the tubular body 14. A suitable ultrasonic bonding process is available from Polyfiltronics, Inc. of Rockland, Mass. 02370. The porous membrane that forms the filter 12 in this example is in the order of seven microns thick, and is available commercially from Poretics Corporation, Livermore, Calif. 94550, and from Nuclepore Corporation, Pleasonton, Calif. 94566.
As noted above, material distorting affects developed at the mounting surface 18 during this securing of the filter peripheral portion to the mounting surface, including for example heat and solvent action, are isolated from the positioning rim 16 by way of the barrier 30 and including the trough 34. Further, material that becomes fluid or otherwise dislodged during the mounting process--such as material of the filter and/or of the tubular body cylindrical wall--, and which tends to move radially inwardly on the annular mounting surface 18, is trapped or otherwise received in the barrier trough 34. The trough thus prevents such material from being deposited on, or otherwise distorting or disfiguring, the positioning rim 16. The barrier 30 thus ensures that the rim 16 positions the filter central portion 12a with the desired shape or contour, e.g., planar flatness.
FIG. 4 shows another device 50 according to the invention and having an oval-shaped portion 52 of a filter 54 for collecting particles and for transferring them to a receiver such as a viewing slide. The device 50 has a tubular support body 56, elongated along an axis 58, and forms an eliptical filter-positioning rim 60. The rim is flat, i.e. planar, and is in a plane that extends diagonally across the circular cross-section of the illustrated body 56.
Axially-spaced inwardly on the tubular body 56 from the rim 60 is a mounting shoulder 62 that projects radially outward on the tubular outer wall of the body 56. The shoulder forms an annular mounting surface to which a peripheral portion 64 of the filter 54 attaches, for attaching the filter to the body. The illustrated mounting surface is oval-shaped, i.e. eliptical, and is preferably generally parallel to the positioning rim 60.
The device 50 also has a barrier trough 66 that axially recesses the mounting surface formed by the shoulder 62. The trough is at a radially inner location on the shoulder, adjacent the tubular wall of the body 56.
The filter 54 is attached to the body 56 by securing the peripheral portion 64 to the mounting surface formed by the shoulder 62. The method of securing can employ a technique such as ultrasonic welding, thermal bonding or solvent bonding. The further structure and method of manufacture for the device 50 can be in accord with the preceding description, including the description of the device 10 shown in FIGS. 1-3.
FIGS. 5-7 show another device 60 according to the invention with a surface-collecting filter 62 mounted on a tubular body 64. As with the embodiments of the invention shown in FIGS. 1 through 4, a rim 66 at an open end of the body 64 positions a central portion 62a of the filter in a planar configuration. The filter 62 is secured at a peripheral portion 62b to a mounting surface 68 that is recessed inwardly on the body 64 from the rim 66. Also, the device 60 includes a barrier, generally shown at 70, on the body 64 which is interposed between the positioning rim 66 and the mounting surface 68. The features and advantages of the barrier 70 are similar to those of barrier 30 discussed above as they relate to the device 10.
Differently from the previously described embodiments of the invention, however, as shown in FIG. 6, the tubular body 64 is closed at its axial end 80 spaced from the rim 66. Additionally, the body 64 has a fluid coupling 82 for enabling a pressure to be applied across the filter 62, as used for the collection and the transfer of particles.
In the illustrated embodiment, having a hollow cylindrical body 64, the coupling 82 includes a sealing surface 84 and one or more apertures. The illustrated sealing surface is a flat, i.e., planar, surface on the exterior wall of the body 64.
It should be understood, however, that the sealing surface 84 can take other forms such as, for example, conical or spherical. Any surface adapted for providing a fluid-tight seal is suitable. The apertures 86 and 88 extend through the wall of the body 64 from the sealing surface 84 to enable the fluid couplings of an external pressure source (not shown) to be removably and replaceably placed in abutment with the surface 84 and thereby to couple fluid pressure to the interior of the body 64 by way of each passage formed by each aperture 86 and 88. Typically, one aperture 86, 88 serves as a pressure control port while the other serves as a pressure monitoring port.
As mentioned above, however, it is not necessary that coupling 82 have two apertures 86 and 88. Indeed, as shown in FIG. 5A, a device 60A can be formed with a coupling 82A having only one aperture 86A. In this embodiment, as described below in greater detail, a coupling block 96A of a particle processing instrument can interact with the coupling 82A to place pressure monitoring and control sources (not shown) in fluid communication with the aperture 86A.
In either configuration, the sealing surface 84 provides a surface receptive to a fluid-tight connection with pressure control and monitoring source connections. Accordingly, the general concepts of particle collection and transfer pertaining to the above discussed embodiments of the invention are also applicable to the device 60.
A further feature of the device 60 is embodied in the closed axial end 80 and the intermediately disposed pressure source coupling 82. These features improve the intra-sample isolation of the particle processing instrument with which the device is used. That is, by eliminating the need for a cover plate 38 (FIG. 2), such as is required by devices 10 and 50, the likelihood of inter-sample contamination is diminished. The device 60 is entirely self-contained.
Additionally, after the collected cells are transferred from the surface-collecting filter element, fluid drawn into the body, i.e., filtrate, can be blown back through the filter element out of the tubular support body. In this manner, a particle processing instrument with which the particle collecting and transferring device 60 is used does not need to have a waste disposal circuit because after cell collection and transfer, filtrate can be returned, as discussed above, to the sample vial.
Another feature of the device 60 is that the coupling 82 is located on the tubular body 64 spaced from both axial ends by distances greater than a maximum liquid depth to be drawn into the body 64 in accordance with the particle collection and transfer operations described above. Accordingly, whatever the vertical orientation of the device 60, whether axial end 80 up during particle collection, or filter end up during particle transfer as in FIGS. 5 and 6, the coupling 82 is vertically above the liquid in the tubular body 64. The pressure source connection applied to the coupling 82, therefore, can be isolated from the liquid sample. This further serves to protect the integrity of individual samples.
With further reference to FIGS. 5, 6, and 7, the illustrated device 60 includes an orienting key 90 and a holding recess having an angled detent surface 92, both on the outer wall of the body and adjacent the closed axial end 80. While the illustrated holding recess employs an angled detent surface 92 for releasably engaging an external clamping member to hold the device 60 axially, the detent surface 92 is not required. The illustrated key 90 is circumferentially aligned--or otherwise selectively located--with respect to the coupling 82 so that a particle processing instrument can selectively rotationally orient the body 64 about its axis of elongation, and hence in the horizontal plane of FIG. 7, to align the coupling 82 with external pressure control and monitoring source connections.
The coupling 82, orienting key 90 and holding recess 92 facilitate using the device 60 in the automated collection and transfer of particles, as FIG. 8 shows. An automated instrument indicated generally at 94 has a coupling block 96 connected to pressure conduits 98, has a rotationally-orienting guide 100, and has a holding finger 102. In use, the device 60 is oriented with the closed end 80 uppermost, and raised axially, along arrow 106, to seat the key 90 in the guide 100 that fixes the orientation of the device rotationally along arrow 104. Continued upward movement of the device snap-fits the holding recess 92 with the finger 102, to hold the device 60 in place vertically. Other means for securing the device 60 will be apparent to those skilled in the art. By fixing the orientation of the device by seating the key 90 in the guide 100 the instrument 94 "knows" the position of coupling 82. The instrument can then manipulate the device 60 with a wrist 103 to locate the coupling 82 for ready alignment with the coupling block 96, which the instrument mounts as on an arm or other structure for movement along arrow 108 selectively into and out of fluid-tight engagement of the conduits 98 with the apertures 86 and 88.
One preferred embodiment of filter attachment involves a first thermal bonding step, wherein the filter is welded by heat to the rim of the support body. Then, to ensure appropriate tensioning of the filter so as to provide a uniformly planar surface, a second step of heat-shrinking the filter is employed.
FIG. 9 shows fabrication apparatus used in one mode of attachment of a surface-collecting filter 202 to a tubular body 204 by way of a thermal-bonding process. In the fabrication, the surface-collecting filter 202 is disposed upon a rim 206 at one end of the tubular body 204. The illustrated thermal bonding fabrication equipment is essentially an arbor press with a heated ram 208. The ram tip 210, which is shaped like a horn or hollow tube having approximately the same diameter as the rim 206 of the tubular body 204, is pressed directly against the filter 202 and is maintained at a temperature capable of welding the filter 202 to the rim 206 of the body 204. The ram tip temperature preferably is controlled, for instance, with digital control to obtain ±1° F. accuracy.
The contact pressure between the ram tip 210, the filter 202, and the rim 206 is controlled, in the illustrated equipment, by supporting the body 204 on an air cylinder 212 mounted on the press base 214. The press ram 208 is lowered until it engages a stop. The air cylinder 212 on the base then takes up the load. The load can be set by varying the pressure to the air cylinder 212. The dwell time of the bonding step, i.e., the time the ram tip 210 remains pressed against the filter 202 and rim 206, can be controlled by timing and reversing the direction of the air cylinder 212 to remove the load and heat on the rim 206 and filter 202. For instance, a limit switch (not shown) can activate a timer when the arbor ram 208 hits a stop, to determine the dwell time of the ram tip 210 against the filter 202 and rim 206.
A control unit 215, also shown in FIG. 9, can provide control of the ram tip temperature, compression force and dwell time. The control unit is preferably driven by a microprocessor, with connections to a pressure sensing unit in the air cylinder 212, a temperature sensing unit in the ram tip 210 and a microswitch activated by the ram 208 engaging its stop. A control unit 215 for this purpose can be provided by those skilled in the art using known techniques.
Upon lowering of the ram 208 and engagement of the stop, the control unit 215 actuates a pneumatic pump or compressed air source connected to the air cylinder 212. The control unit monitors and adjusts the pressure to the air cylinder such that it matches the desired compression force when the ram tip is contacted by the filter and body. The dwell time of this contact is determined relative to the contacting of the stop by the ram, or alternatively, it can be relative to the achievement of a set pressure value in the air cylinder 212. At the end of the predetermined dwell time, the control unit release the pressure in the air cylinder 212, thus removing the body and filter from the ram tip.
The control unit senses and adjusts the temperature of the ram 208 and ram tip 210 such that the desired ram tip temperature in maintained to within ±1° F.
The operating conditions for the thermal bonding step includes determining temperature, the dwell time, and the bonding force or pressure. For instance, increasing the temperature of the ram can generally be offset by decreasing the dwell time and the compression force, and vice-versa. The process is considered optimal when the cylinder melt is minimal, the wetting of the rim/filter interface is even, and the mechanical strength of the filter 202 bond to the body 204 is high. When the temperature, dwell time and load force parameters are too great, the result can be unwanted deformation of the rim 206. Conversely, when these parameters are too small, the resulting bond is weak and the filter delaminates more easily from the body 206. One particularly useful test of these process conditions comes from determining the quality of a slide produced by the deposition of sample material from the filter by the particle collecting-and-transfer device.
After the filter 202 is attached to the tubular body 204, the filter 202 is trimmed to approximate the diameter of the body 204. This eliminates excess filter material which might interfere with the particle collection and transfer process.
One preferred filter material for the illustrated thermal bonding fabrication method is polycarbonate, and one preferred material for the tubular body is polystyrene. The process parameters for the mechanical bonding of the polycarbonate filter to the polystyrene rim in the manner described above with the equipment of FIG. 9, are as follows:
______________________________________Ram Tip Temperature: 275-350° F.Compression Force 20-60 lbsDwell time .75 to 2.0 secondsRam Tip Configuration Outer Dia. 1.0 in Inner Dia. .89 in______________________________________
The melting point of polycarbonate is higher than that of polystyrene, therefore under these conditions, the heat from the ram tip, conducted through the filter, causes the rim 106 to melt and form a mechanical bond with the polycarbonate filter. One specific preferred combination of parameters for the thermally induced mechanical bonding of the filter to the body is:
______________________________________Ram Tip Temperature: 350° F.Compression Force 40 lbsDwell time .75 seconds______________________________________
Furthermore, it has been found that the transfer of particles from the collection filter to a microscope slide is enhanced by performing a filter-shrinking step, preferably after the step of thermally bonding the filter to the tubular body. The filter-shrinking step uniformly tensions the filter to enhance the flat, wrinkle-free disposition of the filter on the body 206. Referring to FIG. 10, one apparatus for performing the filter-shrinking step uses a variable temperature hot air source 230, and a flow-directing baffle 220 to direct a hot air flow 224 onto the filter 202 secured on the body 206. The tubular body 206, with the thermally bonded filter 202 is passed under the flow-directing baffle 220 of the hot air source at a controlled speed and a selected minimal spacing 226. The hot air temperature is maintained such that the filter 202 contracts and is tensioned substantially uniformly in all directions. To vary the duration of heat application, the speed at which the tubular body 204 is passed through the heat flow 224 can be varied. The duration of heat exposure is inversely proportional to the speed at which the cylinder is passed through the heat flow.
The process parameters for the heat-shrinking step carried out by the illustrated embodiment are:
______________________________________air temperature 250-400° F.duration of heat 0.5 to 2.0 in/secapplication (expressed interms of cylinder speed)______________________________________
In one specific illustrative practice, the hot air source employed is a variable temperature hot air gun (Master Appliance, VariTemp Heat Gun VT 752C) and a flow directing baffle with output dimensions of 8 inches × 0.2 inches. The air temperature is maintained at 400° F., and the tubular body 104 is passed through the heated air flow at a speed of 1.3 inches per second. When the tubular body 104 is positioned directly beneath the flow directing baffle 220, the items are approximately 0.5 inches apart. Those skilled in the art will appreciate that other combinations of parameter values can be used.
It will thus be seen that the invention efficiently obtains the objects set forth above, among those made apparent from the previous description. Since certain changes may be made in carrying out the above process or in the device set forth without departing from the scope of the invention, it is intended that all matter contained in the above description or shown in the accompanying drawing be interpreted as illustrative and not in a limiting sense.
It is also to be understood that the following claims are to cover all generic and specific features of the invention described herein, and all statements of the scope of the invention which, as a matter of language, might be said to fall there between.
|Cited Patent
|Filing date
|Publication date
|Oct 14, 1968
|Oct 26, 1971
|Becton Dickinson Co
|Filter cassette and holder therefor
|Mar 2, 1970
|Aug 8, 1972
|Volu Sol Chem And Mfg Co Inc
|Throw-away filter assembly
|May 21, 1976
|Jan 3, 1978
|Louis Bucalo
|Method and structure for treating body fluids with cells therein
|Sep 7, 1976
|Mar 6, 1979
|W. C. Heraeus Gmbh
|Cultivation containers for cultures, microorganisms, cells, tissue and the like
|Feb 15, 1978
|Jan 22, 1980
|Tecator Instrument Ab
|Extraction apparatus, preferably for analyzing purposes
|Feb 27, 1981
|Nov 2, 1982
|Sybron Corporation
|Disposable, one-piece filter unit
|Feb 9, 1982
|Sep 27, 1983
|Carl Schliecher & Schuell Gmbh & Co., Kg
|Pressure filtering device
|Mar 18, 1985
|May 12, 1987
|Burron Medical Inc.
|Micron chamber I.V. with support ring
|Oct 5, 1987
|Aug 30, 1988
|Whatman Reeve Angel Plc
|Membrane filter tube and method of preparation
|Aug 10, 1987
|Jul 18, 1989
|Manufactures Hanover Trust Company
|Method of making plastic filter units having a welded cellulose filter
|Jan 25, 1988
|Jan 2, 1990
|Abbott Laboratories
|Sample filtration device
|Sep 6, 1988
|May 1, 1990
|Eastman Kodak Company
|Sliding valve for vent of liquid collecting compartment
|Dec 5, 1988
|May 22, 1990
|Costar Corporation
|Multiwell filter plate vacuum manifold assembly
|Sep 15, 1989
|Apr 30, 1991
|Branson Ultrasonics Corporation
|Method of ultrasonically cutting and sealing thermoplastic workpieces particularly a filter
|Jun 22, 1989
|Oct 29, 1991
|Brandeis University
|Replica plating device with an integral marking element
|Title not available
|Aug 26, 1988
|Mar 9, 1989
|Hitachi Ltd
|Sep 24, 1987
|Mar 30, 1988
|Becton Dickinson and Company
|A method and device for concentration of particles on a solid surface
|Jul 2, 1991
|Sep 16, 1992
|Cytyc Corporation
|Apparatus for collection and transfer of particles and manufacture thereof
|Title not available
|Amicon , Laboratory Separation, Membrane Filtration Chromatography , Pub. No. 533, pp. 1 76, (1988).
|Amicon®, "Laboratory Separation, Membrane Filtration Chromatography", Pub. No. 533, pp. 1-76, (1988).
|Costar Product Catalog Featuring Cell Culture, Liquid Handling, Immunology, and General Laboratory, pp. 1 31.
|Costar® Product Catalog Featuring "Cell Culture, Liquid Handling, Immunology, and General Laboratory," pp. 1-31.
|Polyfiltronics Brochure, "Solve Your Separation Problems with Unique Membrane Encapsulation".
|Polyfiltronics Brochure, Solve Your Separation Problems with Unique Membrane Encapsulation .
|Citing Patent
|Filing date
|Publication date
|Oct 14, 1999
|Jul 9, 2002
|Imv Technologies
|Method of making a component consisting of a support and a membrane welded thereto, in particular a plug for a straw, and membrane-support
|Dec 1, 2005
|Apr 15, 2008
|Cytyc Corporation
|Filter contamination control device
|Dec 1, 2005
|Jan 6, 2009
|Cytyc Corporation
|Fluid level regulator
|Oct 21, 2004
|Mar 24, 2009
|Cytyc Corporation
|Reduced aperture biological specimen collection and transfer device
|Mar 8, 2005
|Jul 7, 2009
|Cytyc Corporation
|Specimen vial cap handler and slide labeler
|May 5, 2005
|Mar 30, 2010
|Cytyc Corporation
|Filter assembly for molecular testing
|Dec 1, 2005
|Jun 8, 2010
|Infosys Technologies Ltd.
|Automated relationship traceability between software design artifacts
|Dec 12, 2008
|Jan 11, 2011
|Cytyc Corporation
|Fluid level regulator
|Dec 19, 2008
|Mar 20, 2012
|Cytyc Corporation
|Active grip filter plug for sample collection devices
|Oct 6, 2009
|Jun 11, 2013
|Cytyc Corporation
|Microfluidic apparatus and method for preparing cytological specimens
|Apr 14, 2003
|Aug 6, 2013
|Robert Cary Leif
|Centrifugal cytology system, chamber block and method for the preparation of treated monolayers of sample material
|Sep 11, 2009
|Mar 11, 2014
|Hologic, Inc.
|Methods and systems for collecting cells of a biological specimen
|Nov 12, 2003
|May 12, 2005
|Cytyc Corporation
|Specimen filter container having data storage
|Apr 27, 2004
|Oct 27, 2005
|Cytyc Corporation
|Microscope slide mask and method
|May 5, 2005
|Nov 10, 2005
|James Linder
|Filter assembly for molecular testing
|Oct 21, 2004
|Apr 27, 2006
|Cytyc Corporation
|Reduced aperture biological specimen collection and transfer device
|Dec 23, 2005
|Jul 20, 2006
|Diamics, Inc.
|Systems and methods for collection of cell clusters
|Dec 23, 2005
|Aug 24, 2006
|Diamics, Inc.
|Systems and methods for detecting abnormal cells
|Mar 8, 2005
|Sep 21, 2006
|Cytyc Corporation
|Specimen vial cap handler and slide labeler
|Oct 15, 1999
|Apr 19, 2000
|IMV Technologies
|Process for manufacturing an element constituted of a support and a membrane welded to it, in particular a stop for a straw and assembly of membrane-supports obtained by this process
|Sep 8, 2010
|Mar 17, 2011
|Cytyc Corporation
|Methods and systems for collecting cells of a biological specimen
|U.S. Classification
|156/73.1, 156/309.6, 264/445, 156/86
|International Classification
|Cooperative Classification
|European Classification
|Dec 27, 2001
|Fee payment
Year of fee payment: 4
|Jan 22, 2002
|Maintenance fee reminder mailed
|Dec 30, 2005
|Fee payment
Year of fee payment: 8
|Oct 26, 2007
Owner name: GOLDMAN SACHS CREDIT PARTNERS L.P.,CALIFORNIA
Free format text: PATENT SECURITY AGREEMENT;ASSIGNOR:CYTYC CORPORATION;REEL/FRAME:020018/0529
Effective date: 20071022
|Jul 29, 2008
|Dec 30, 2009
|Fee payment
Year of fee payment: 12
|Aug 25, 2010
Owner name: R2 TECHNOLOGY, INC., CALIFORNIA
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: BIOLUCENT, LLC, CALIFORNIA
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP, MA
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: CYTYC CORPORATION, MASSACHUSETTS
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: CYTYC SURGICAL PRODUCTS III, INC., MASSACHUSETTS
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: SUROS SURGICAL SYSTEMS, INC., INDIANA
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP, MASSA
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: THIRD WAVE TECHNOLOGIES, INC., WISCONSIN
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: DIRECT RADIOGRAPHY CORP., DELAWARE
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: HOLOGIC, INC., MASSACHUSETTS
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819
Owner name: CYTYC PRENATAL PRODUCTS CORP., MASSACHUSETTS
Free format text: TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS;ASSIGNOR:GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT;REEL/FRAME:024944/0315
Effective date: 20100819


text:
My Nonprofit Reviews
Review for Services For Brain Injury, San Jose, CA, USA
I brought my husband to SBI at the point that insurance stopped paying to rehabilitate him from a severe brain injury and stroke. I discovered there is no where else in the Bay Area to get the kind of rehab that SBI offers. They provided my husband with programs for personal and social readjustment -- he was anti-social and difficult to interact with. Once he got past that, he went through SBI's vocational training. SBI also places their clients in jobs and provides coaches so clients stay employed. What a huge relief that there was someplace to take my husband for this kind of help. It wasn't a perfect recovery path for him but he is happy now and has a part-time job and is fully independent. I never would have thought that was possible and neither did his doctors. The staff at SBI is dedicated and very skilled. It is a unique facility that provides the most critical rehab which gets people get back to living their lives. I was impressed and very grateful.
More Feedback
How would you describe the help you got from this organization?
How likely are you to recommend this organization to a friend?
How do you feel you were treated by this organization?
Very Well
How did you find this group?
Calling around.
What, if any, change in your life has this group encouraged?
Helped my husband get rehabilitated. That created a huge change in my life!
When was your last experience with this nonprofit?


text:
A two-year search for a senior state economist has ended with the selection of Clarksdale native Dr. Sondra Collins, who joined the Mississippi University Research Center after four years as an assistant professor at the University of Southern Mississippi. Collins replaces Dr. Marianne Hill, who retired in the summer of 2013 after more than 20 years with the University Research ...Read More »
Tag Archives: University of Southern Mississippi
Room to learn: USM's Scianna Hall opens for business next week
By TED CARTER The University of Southern Mississippi's College of Business is making a giant leap into the future with the start of classes Aug. 19 in Scianna Hall, a $34 million addition to the Hattiesburg campus. The opening of the building just south of the university's football stadium culminates several years of fund-raising followed by a couple years of construction. ...Read More »
USM enrollment drops 1,400 in 3 years; $5.9M in budget cuts
HATTIESBURG — The University of Southern Mississippi has seen enrollment drop nearly 9 percent since 2011, forcing campus-wide budget cuts for the coming fall. The Hattiesburg American reports that enrollment fell from nearly 16,200 in fall 2011 to less than 14,800 in fall 2014. Douglas Vinzant, vice president for finance and administration, says state appropriations used to play a bigger ...Read More »
Dean: USM College of Nursing needs to move into new building
HATTIESBURG — Katherine Nugent, dean of the College of Nursing at the University of Southern Mississippi, says there are 1,450 reasons why the college needs to move into its as yet unfinished new home in Asbury Hall. She says that's how many students are currently crammed into Harkins Hall, which was built around 1975. Nugent says those cramped quarters lead ...Read More »
Faculty raises at USM the first in years
HATTIESBURG — Susan Hrostowski, associate professor of social work at the University of Southern Mississippi, hasn't gotten a raise in about four years. "We are underpaid," she said. "University faculty (around the country) are paid much more than we are here." In a March letter to newspaper editors, Aubrey Patterson, president of the state College Board, said in six years, ...Read More »
USM provost Wiesenburg returns to Marine Science faculty
HATTIESBURG — University of Southern Mississippi Provost Denis Wiesenburg has resigned from his position as Provost and Vice President for Academic Affairs. The Hattiesburg American reports he will return to the faculty in the Department of Marine Science, effective July 1. Southern Miss President Rodney Bennett said he had accepted Wiesenburg's resignation. "(I) thank him for his service not only ...Read More »
Operations keeps show moving — and then there's gum
Sixteen or so hours overseeing game-day maintenance and clean-up inside Trustmark Stadium normally makes sleep a cinch for 28-year-old Chris Hornberger, the stadium's operation manager. But there's always the gum to think about – or more precisely, the already-been-chewed variety that fans leave on the surface of the wrap-around mezzanine. If not scrapped up right away, the gum turns black ...Read More »
Brannock selected to Archives Leadership Institute
Jennifer Brannock, associate professor and curator of Rare Books and Mississippiana at the University of Southern Mississippi, has been selected as a participant in the 2015 Archives Leadership Institute (ALI). ALI is a program funded by the National Historical Publications and Records Commission, a statutory body affiliated with the National Archives and Records Administration, and is being hosted at Luther ...Read More »
Opening doors for entrepreneurs — State's development centers offer free consulting, coaching and training
By LISA MONTI The Mississippi Small Business Development Centers, a network of resource centers throughout the state, help entrepreneurs open and grow their businesses with free consulting, coaching and training programs. The resource centers serve as a one-stop shop to help owners do the groundwork for starting out in business and operating profitably once the doors are open. Examples of ...Read More »
A HOME AWAY FROM HOME … As long as it has modern technology, meal plans, friends and no parking worries
By LYNN LOFTON The recently completed Century Park South at the University of Southern Mississippi is on the cutting edge of student housing. There are 954 bed spaces in the state-of-the-art $55.6 million complex that was built by the Harrell Contracting Group of Jackson. There was significant site preparation before the two-year building project could get under way with three ...Read More »


text:
You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
May 29
Sounds Like: Biggie, Jay Z, Lil Wayne
Bio: Young Rapper By The Name Of Da'Vinci ThaGod Trying To Turn Dreams Into Reality. Music Means More Than The World To Me. Originially From Newark, New Jeresey Spent Most Of My Life In Atlanta,Ga Then Made My Way Back To New Jersey. I'm Not In It For The Fame I'm In It For The Passion. Music Is The ...See Full Bio


text:
Recent Posts
Lion New Zealand
Explore NZ
- RT @ShannonRowbury: In Auckland, @psolares learns aboutsteering @ExploreNZ America's Cup Yacht! unscriptd.com/raw/track-and-… http://t.co/D3MpEF0… 18 hours ago
- RT @CommsatTIA: #Auckland Airport's $100,000 competition winners - #Tourism2025 in action! tourism2025.org.nz/news-and-event… @AKL_Airport @YHANewZeala… 1 month ago
- Great suggestions of things to get up to this winter from @goodmag magazine... bit.ly/1QFNrqj 3 months ago
- Chinese tourists turning off NZ package tours nzh.tw/11451178 via @nzherald 4 months ago
- Explore offers new options in Auckland and the Bay of Islands shar.es/1rYUv4 via @TRENZ2014 4 months ago
Author Archives: exploregroup
Spring cleaning…
We are in the process of tidying up our blogs. We plan to combine the products under two new headings, Auckland and Bay of Islands. Watch this space!
Posted in Uncategorized Leave a comment
Canadians are cool, aren't they?
You bet! OK, we were outnumbered, but they know how to enjoy themselves and have a very similar sense of humour to kiwis (and yes I might be a bit biased as I have relatives over there!). A group of … Continue reading
We had the coolest Canadians on board the boats on Saturday…
The day dawned with hardly a cloud in the sky and barely a breath of wind. Perfect for the start of the Swim with Dolphins/Lion New Zealand Dolphin/Sail combination trip. Hopefully the breeze would increase after lunch for the sailing. … Continue reading
Posted in New Zealand Travel Tagged Bay of Islands, dolphin swim, Lion New Zealand, New Zealand, Paihia Leave a comment
Lady Pippa Blake's book: Journey
On 5th December 2001 New Zealand sporting and adventure hero Sir Peter Blake was killed by bandits at the mouth of the Amazon River. In this intimate account, Sir Peter's wife Pippa offers an intensely personal account of their life … Continue reading
Posted in Uncategorized Tagged Lion New Zealand, Peter Blake, Pippa Blake Leave a comment
Lion Maritime Development Charitable Trust
Lion New Zealand is back in the Bay of Islands fundraising for the Charitable Trust, offering day sailings and Dolphin Swimming/Sailing combinations. To find out more about the Trust and how it operates visit the Lion NZ web site: http://www.lionnewzealand.com/index.html
Posted in New Zealand Travel Tagged Bay of Islands, Lion New Zealand Leave a comment


text:
33 search results for London Film Critics' Circle Awards
London Critics' Circle honors Nicolas Roeg
Type: Post | Date: Friday, Dec 2, 2011Director of 'Don't Look Now' and 'Performance' recognized for contribution to British cinema
Oscar Talk: Ep. 66 -- Gotham Awards, NYFCC's FIRST! move, 'Tintin,' London fest and more
Type: Post | Date: Friday, Oct 21, 2011Also: Animated feature contenders, foreign film discussion and special guest Guy Lodge
Review: Low-key drama in the English fenland propels debut feature 'The Goob'
Type: Post | Date: Tuesday, Aug 26, 2014Sean Harris reliably unsettling in Venice Days entry
London critics award 'Boyhood,' 'Under the Skin'
Type: Post | Date: Sunday, Jan 18, 2015Consensus down the line save for Brit-specific categories
Review: Rising Brit star George MacKay is the standout in Duane Hopkins' 'Bypass'
Type: Post | Date: Wednesday, Sep 3, 2014Drugs are bad, MacKay
'Skyfall' comes out on top at Evening Standard Awards
Type: Post | Date: Tuesday, Feb 5, 2013Bond takes his biggest win of the season, but indies rule elsewhere
Robert Redford to receive American Riviera Award at Santa Barbara fest
Type: Post | Date: Tuesday, Dec 17, 2013The 'All is Lost' star honored for his influence of American cinema
Roundup: 'Ralph' rules box office, but 'Flight' takes off
Type: Post | Date: Monday, Nov 5, 2012Also: Haneke speaks reluctantly, and 'Wreck-It Ralph' for Best Pic?
'Argo' and 'Skyfall' tops with UK Regional Critics
Type: Post | Date: Monday, Feb 4, 2013Meanwhile, Team Edward makes its vote count
Relive the 2014-2015 film awards circuit
Type: Post | Date: Monday, Feb 23, 2015Charting the winners and losers of this year's Oscar season


text: If in Phuket- Pum is a great place to start experimenting with and tasting Thai food. We were in Thailand for 15 days and ate at Pum five times. We were staying in Karon but were happy to travel to Patong just to have a meal here. Our children aged 8and 11 loved the food and the restaurant. They enjoyed the chicken satay, fried cashews and vegetables, garlic beef and of course the heavenly yellow mango with the sticky rice. My husband and I enjoyed the green curry ( light and not overly creamy), the fried noodles with the prawn omelette and the herb salad. We even met Pum herself as she worked in the kitchen and patiently showed a budding chef how to properly clean and slice mango. The restaurant itself is quite stylish with beautiful plates, glasses, wall gardens of plants, cute seats with orange cushions placed on them as you sit down. Overall this restaurant is highly recommended for its delicious Thai food, friendly staff, beautiful decor and of course Pum to greet you on return visits. This restaurant is a must for all in Phuket.


text:
1206 Views 1 Reply Latest reply: Oct 23, 2013 9:53 AM by Delgadoh
Delgadoh Oct 23, 2013 9:53 AM
in response to f1svx
Hey f1svx,
I found the following information for you to try out:
If you are experiencing intermittent playback or significant network lag with AirPlay or AirPlay Mirroring, it could be due to a weak Wi-Fi connection, interference, or the distance between the Wi-Fi router and your iOS device, Apple TV or AirPort Express.
Try the following suggestions:
- Ensure that other devices are not trying to stream to the same Apple TV at the same time.
- Turn off Bluetooth on your iOS device by tapping Settings > Bluetooth.
- Ensure that your Wi-Fi router is set up with the recommended settings for the best performance.
- Certain external devices, such as microwave ovens and baby monitors, may interfere with a Wi-Fi network. Try moving or disabling these devices.
- If possible, try to locate your Wi-Fi router in the same room as your iOS device and Apple TV.
- If your wireless and wired networks are the same, try connecting your Apple TV to the router via Ethernet instead of Wi-Fi.
- If the Wi-Fi router has an external antenna, check to see that is it connected properly and in good condition.
- Use the Wi-Fi network troubleshooting guide to resolve interference and other issues.
via: iOS: Troubleshooting AirPlay and AirPlay Mirroring
Welcome to Apple Support Communities!


text: Favorite deal Favorited! Get email updates for this deal? NO YES Retractable 800 dpi Optical USB 2.0 Slim Mouse $5.35 at Sungmart $5.35 Sungmart has the 800 dpi Optical Wired USB 2.0 Slim Mouse with Retractable, Detachable USB Cable (black and pink) for $5.82 - 8% off with coupon code Bens10 (enter at PayPal checkout) = $5.35 with free shipping. Blue is a few cents more with same code. Measures 3.35" x 1.97" x 0.47". CREATE ALERT Deal has expired EXPIRED Posted 1253 days ago by Sharik Report Report this deal Report an Error Close Retractable 800 dpi Optical USB 2.0 Slim Mouse $5.35 at Sungmart Deals can expire unexpectedly at any time. Problem: Out of Stock Deal Expired Other Error (please explain) Comments: (Optional) Submit


text:
Today is the final day to register for this year's Fun Run at the Knoxville Recreation Center.
Keywords: fun run, Knoxville Recreation Center
The Knoxville Recreation Center will be hosting their 3rd annual Fun Run this month.
May is National Physical Fitness and Sports Month which is an ideal time to maintain a healthy lifestyle.
Keywords: fun run, Knoxville Recreation Center, physical fitness
The Cubs and Cardinals have never played each other before in postseason baseball. Until now. Who will you be rooting for during the series?
View Results
call: (641) 842-3161 | (641) 628-8672


text:
TrainspottingDirector: Danny Boyle
Cast: Danny Boyle, Ewan McGregor, Ewen Bremner, Jonny Lee Miller
View All Available Formats & Editions
Director Danny Boyle's throbbing punk-spirited film explodes from the first frame as a heady mix of brilliant camera work, witty dialogue, and excellent soundtrack choices. On DVD, quick-moving montage never slows down technically or thematically. The DVD displays the extreme, hyperkinetic colors of the film in superior fashion, and the gritty transfer suits the film… See more details below
- Overview
- Editorial Reviews
- Product Details
- Special Features
- Related Subjects
- Cast & Crew
- Scene Index
- Menu
- Videos
Director Danny Boyle's throbbing punk-spirited film explodes from the first frame as a heady mix of brilliant camera work, witty dialogue, and excellent soundtrack choices. On DVD, quick-moving montage never slows down technically or thematically. The DVD displays the extreme, hyperkinetic colors of the film in superior fashion, and the gritty transfer suits the film perfectly. While not the cleanest DVD presentation, it is highly appropriate in presenting the drugged, confused lives of Renton, Begbie, and friends. The audio had to immediately smack of visceral clarity to get through the sometimes difficult accents of a few of the characters, and it meets the challenge (though anglophobes may want to turn on the closed captioning). The CD-quality soundtrack, with songs by Underworld, New Order, Primal Scream, and others, adds infinite coolness to the proceedings. The entire audio production is excellent, particularly Ewan McGregor's narration. The only special feature to be found is the "Chapter Selection" menu, which allows instant access to all 25 chapters via still images and captions. Trainspotting is a fun film with a spot-on soundtrack particularly suited to DVD.
Editorial Reviews
Product Details
- Release Date:
- 03/25/1998
- 0717951000224
- Original Release:
- 1996
- Rating:
- Source:
- Walt Disney Video
- Region Code:
- 1
- Presentation:
- [Wide Screen]
- Sound:
- [Dolby Digital, stereo]
- Time:
- 1:58:00
Special Features
Cast & Crew
|Ewan McGregor
|Mark Renton
|Ewen Bremner
|Jonny Lee Miller
|Sick Boy
|Kevin McKidd
|Robert Carlyle
|Francis Begbie
|Kelly MacDonald
|Keith Allen
|Kevin Allen
|Fiona Bell
|Diane's Mother
|James Cosmo
|Mr Renton
|Kate Donnelly
|Victor Eadie
|Vincent Friell
|Diane's Father
|Shirley Henderson
|Pauline Lynch
|Andrew Macdonald
|Flat Buyer
|Stuart McQuarrie
|Gavin/US Tourist
|Peter Mullan
|Eddie Nestor
|Estate Agent
|Eileen Nicholas
|Mrs Renton
|Billy Riddoch
|Gail's Father
|Hugh Ross
|Annie Louise Ross
|Gail's Mother
|Susan Vidler
|Finlay Welsh
|Irvine Welsh
|Dale Winton
|Game Show Host
Technical Credits
|Danny Boyle
|Rachael Fleming
|Costumes/Costume Designer
|Tracey Gallagher
|Art Director
|David Gilchrist
|Asst. Director
|Masahiro Hirakubo
|John Hodge
|Ben Johnson
|Asst. Director
|Andrew Macdonald
|Robert McCann
|Ray Merrin
|Sound/Sound Designer
|Colin Nicolson
|Sound/Sound Designer
|Andy Pryor
|Kave Quinn
|Production Designer
|Brian Saunders
|Sound/Sound Designer
|Gail Stevens
|Mark Taylor
|Sound/Sound Designer
|Brian Tufano
|Irvine Welsh
|Source Author
Scene Index
0. Chapter Selection
1. Program Start [:17]
2. Opening Credits [5:51]
3. Stage 1: Preparation [2:11]
4. Worst Toilet In Scotland [3:05]
5. Theory Of Life [2:36]
6. Preparation And Process [:10]
7. Begbie's Story [2:03]
8. "Temptation" [3:25]
9. First Shag In Ages [3:54]
10. Traditional Breakfast [4:47]
11. Colonized By Wankers [3:36]
12. Relapsing [2:29]
13. Edinburgh Festival [3:33]
14. Courting Disaster [4:03]
15. "Perfect Day" [:19]
16. House Arrest [2:55]
17. Bad Blood [5:17]
18. No Such Thing As Society [5:51]
19. "Just Wankers" [4:34]
20. Desirable Properties [3:29]
21. Lust For Life [2:01]
22. Cash From Chaos [:03]
23. Accidental Big Deal [1:43]
24. Choose Life [2:20]
25. Closing Credits [2:35]
Additional Titles
Customer Reviews
Average Review:
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >