text: Diabetes Obesity Studies http://diabetes.diabetesjournals.org Diabetes RSS feed -- recent Obesity Studies articles 1939-327X Diabetes 0012-1797 Diabetes http://diabetes.diabetesjournals.org/icons/banner/title.gif http://diabetes.diabetesjournals.org http://diabetes.diabetesjournals.org/cgi/content/short/64/10/3452?rss=1 Adipose tissue dysfunction in obesity has been linked to low-grade inflammation causing insulin resistance. Transcriptomic studies have identified death-associated protein kinase 2 (DAPK2) among the most strongly downregulated adipose tissue genes in human obesity, but the role of this kinase is unknown. We show that mature adipocytes rather than the stromal vascular cells in adipose tissue mainly expressed DAPK2 and that DAPK2 mRNA in obese patients gradually recovered after bariatric surgery–induced weight loss. DAPK2 mRNA is also downregulated in high-fat diet–induced obese mice. Adenoviral-mediated DAPK2 overexpression in 3T3-L1 adipocytes did not affect lipid droplet size or cell viability but did increase autophagic clearance in nutrient-rich conditions, dependent on protein kinase activity. Conversely, DAPK2 inhibition in human preadipocytes by small interfering RNA decreased LC3-II accumulation rates with lysosome inhibitors. This led us to assess autophagic clearance in adipocytes freshly isolated from subcutaneous adipose tissue of obese patients. Severe reduction in autophagic flux was observed in obese adipocytes compared with control adipocytes, inversely correlated to fat cell lipids. After bariatric surgery, adipocyte autophagic clearance partially recovered proportional to the extent of fat cell size reduction. This study links adipocyte expression of an autophagy-regulating kinase, lysosome-mediated clearance and fat cell lipid accumulation; it demonstrates obesity-related attenuated autophagy in adipocytes, and identifies DAPK2 dependence in this regulation. ]]> 2015-09-24T12:00:50-07:00 info:doi/10.2337/db14-1933 hwp:master-id:diabetes;db14-1933 American Diabetes Association 2015-10-01 Obesity Studies 64 10 3452 3463 http://diabetes.diabetesjournals.org/cgi/content/short/64/10/3464?rss=1 Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear. We aimed to identify obesity-associated molecular features that may contribute to obesity-related diseases. Using circulating monocytes from 1,264 Multi-Ethnic Study of Atherosclerosis (MESA) participants, we quantified the transcriptome and epigenome. We discovered that alterations in a network of coexpressed cholesterol metabolism genes are a signature feature of obesity and inflammatory stress. This network included 11 BMI-associated genes related to sterol uptake (LDLR, MYLIP), synthesis (SCD, FADS1, HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and efflux (ABCA1, ABCG1), producing a molecular profile expected to increase intracellular cholesterol. Importantly, these alterations were associated with T2D and coronary artery calcium (CAC), independent from cardiometabolic factors, including serum lipid profiles. This network mediated the associations between obesity and T2D/CAC. Several genes in the network harbored C-phosphorus-G dinucleotides (e.g., ABCG1/cg06500161), which overlapped Encyclopedia of DNA Elements (ENCODE)-annotated regulatory regions and had methylation profiles that mediated the associations between BMI/inflammation and expression of their cognate genes. Taken together with several lines of previous experimental evidence, these data suggest that alterations of the cholesterol metabolism gene network represent a molecular link between obesity/inflammation and T2D/CAC. ]]> 2015-09-24T12:00:50-07:00 info:doi/10.2337/db14-1314 hwp:master-id:diabetes;db14-1314 American Diabetes Association 2015-10-01 Obesity Studies 64 10 3464 3474 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3104?rss=1 Improvement in type 2 diabetes after Roux-en-Y gastric bypass (RYGB) has been attributed partly to weight loss, but mechanisms beyond weight loss remain unclear. We performed an ancillary study to the Diabetes Surgery Study to assess changes in incretins, insulin sensitivity, and secretion 1 year after randomization to lifestyle modification and intensive medical management (LS/IMM) alone (n = 34) or in conjunction with RYGB (n = 34). The RYGB group lost more weight and had greater improvement in HbA1c. Fasting glucose was lower after RYGB than after LS/IMM, although the glucose area under the curve decreased comparably for both groups. Insulin sensitivity increased in both groups. Insulin secretion was unchanged after LS/IMM but decreased after RYGB, except for a rapid increase during the first 30 min after meal ingestion. Glucagon-like peptide 1 (GLP-1) was substantially increased after RYGB, while gastric inhibitory polypeptide and glucagon decreased. Lower HbA1c was most strongly correlated with the percentage of weight loss for both groups. At baseline, a greater C-peptide index and 90-min postprandial C-peptide level were predictive of lower HbA1c at 1 year after RYGB. β-Cell glucose sensitivity, which improved only after RYGB, and improved disposition index were associated with lower HbA1c in both groups, independent of weight loss. Weight loss and preserved β-cell function both predominantly determine the greatest glycemic benefit after RYGB. ]]> 2015-08-20T12:00:50-07:00 info:doi/10.2337/db14-1870 hwp:master-id:diabetes;db14-1870 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3104 3110 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3111?rss=1 This study investigated how maternal overnutrition and obesity regulate expression and activation of proteins that facilitate lipid transport in the placenta. To create a maternal overnutrition and obesity model, primiparous C57BL/6 mice were fed a high-fat (HF) diet throughout gestation. Fetuses from HF-fed dams had significantly increased serum levels of free fatty acid and body fat. Despite no significant difference in placental weight, lipoprotein lipase (LPL) protein levels and activity were remarkably elevated in placentas from HF-fed dams. Increased triglyceride content and mRNA levels of CD36, VLDLr, FABP3, FABPpm, and GPAT2 and -3 were also found in placentas from HF-fed dams. Although both peroxisome proliferator–activated receptor- (PPAR) and CCAAT/enhancer binding protein-α protein levels were significantly increased in placentas of the HF group, only PPAR exhibited a stimulative effect on LPL expression in cultured JEG-3 human trophoblasts. Maternal HF feeding remarkably decreased SIRT1 expression in placentas. Through use of an SIRT1 activator and inhibitor and cultured trophoblasts, an inhibitory effect of SIRT1 on LPL expression was demonstrated. We also found that SIRT1 suppresses PPAR expression in trophoblasts. Most importantly, inhibition of PPAR abolished the SIRT1-mediated regulatory effect on LPL expression. Together, these results indicate that maternal overnutrition induces LPL expression in trophoblasts by reducing the inhibitory effect of SIRT1 on PPAR. ]]> 2015-08-20T12:00:50-07:00 info:doi/10.2337/db14-1627 hwp:master-id:diabetes;db14-1627 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3111 3120 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3121?rss=1 Inflammation and lipid accumulation are hallmarks of muscular pathologies resulting from metabolic diseases such as obesity and type 2 diabetes. During obesity, the hypertrophy of visceral adipose tissue (VAT) contributes to muscle dysfunction, particularly through the dysregulated production of adipokines. We have investigated the cross talk between human adipocytes and skeletal muscle cells to identify mechanisms linking adiposity and muscular dysfunctions. First, we demonstrated that the secretome of obese adipocytes decreased the expression of contractile proteins in myotubes, consequently inducing atrophy. Using a three-dimensional coculture of human myotubes and VAT adipocytes, we showed the decreased expression of genes corresponding to skeletal muscle contractility complex and myogenesis. We demonstrated an increased secretion by cocultured cells of cytokines and chemokines with interleukin (IL)-6 and IL-1β as key contributors. Moreover, we gathered evidence showing that obese subcutaneous adipocytes were less potent than VAT adipocytes in inducing these myotube dysfunctions. Interestingly, the atrophy induced by visceral adipocytes was corrected by IGF-II/insulin growth factor binding protein-5. Finally, we observed that the skeletal muscle of obese mice displayed decreased expression of muscular markers in correlation with VAT hypertrophy and abnormal distribution of the muscle fiber size. In summary, we show the negative impact of obese adipocytes on muscle phenotype, which could contribute to muscle wasting associated with metabolic disorders. ]]> 2015-08-20T12:00:50-07:00 info:doi/10.2337/db14-0796 hwp:master-id:diabetes;db14-0796 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3121 3134 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3135?rss=1 Low mitochondrial number and activity have been suggested as underlying factors in obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which mitochondrial dysfunction manifests in adipose tissue after the onset of obesity remains unknown. Here we examined subcutaneous adipose tissue (SAT) samples from healthy monozygotic twin pairs, 22.8–36.2 years of age, who were discordant (BMI >3 kg/m2, mean length of discordance 6.3 ± 0.3 years, n = 26) and concordant (BMI <3 kg/m2, n = 14) for body weight, and assessed their detailed mitochondrial metabolic characteristics: mitochondrial-related transcriptomes with dysregulated pathways, mitochondrial DNA (mtDNA) amount, mtDNA-encoded transcripts, and mitochondrial oxidative phosphorylation (OXPHOS) protein levels. We report global expressional downregulation of mitochondrial oxidative pathways with concomitant downregulation of mtDNA amount, mtDNA-dependent translation system, and protein levels of the OXPHOS machinery in the obese compared with the lean co-twins. Pathway analysis indicated downshifting of fatty acid oxidation, ketone body production and breakdown, and the tricarboxylic acid cycle, which inversely correlated with adiposity, insulin resistance, and inflammatory cytokines. Our results suggest that mitochondrial biogenesis, oxidative metabolic pathways, and OXPHOS proteins in SAT are downregulated in acquired obesity, and are associated with metabolic disturbances already at the preclinical stage. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db14-1937 hwp:master-id:diabetes;db14-1937 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3135 3145 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3146?rss=1 The first epigenome-wide association study of BMI identified DNA methylation at an HIF3A locus associated with BMI. We tested the hypothesis that DNA methylation variants are associated with BMI according to intake of B vitamins. In two large cohorts, we found significant interactions between the DNA methylation–associated HIF3A single nucleotide polymorphism (SNP) rs3826795 and intake of B vitamins on 10-year changes in BMI. The association between rs3826795 and BMI changes consistently increased across the tertiles of total vitamin B2 and B12 intake (all P for interaction <0.01). The differences in the BMI changes per increment of minor allele were –0.10 (SE 0.06), –0.01 (SE 0.06), and 0.12 (SE 0.07) within subgroups defined by increasing tertiles of total vitamin B2 intake and –0.10 (SE 0.06), –0.01 (SE 0.06), and 0.10 (SE 0.07) within subgroups defined by increasing tertiles of total vitamin B12 intake. In two independent cohorts, a DNA methylation variant in HIF3A was associated with BMI changes through interactions with total or supplemental vitamin B2, vitamin B12, and folate. These findings suggest a potential causal relation between DNA methylation and adiposity. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db15-0264 hwp:master-id:diabetes;db15-0264 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3146 3154 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3155?rss=1 Morbidly obese individuals are predisposed to a wide range of disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, fatty liver disease, and certain cancers. Remarkably, all of these disorders can be improved or prevented by Roux-en-Y gastric bypass (RYGB) surgery. We have reported that decreased AMPK activity, together with increased oxidative stress and inflammation in adipose tissue, is associated with insulin resistance in morbidly obese bariatric surgery patients. In the current study, we assessed how these parameters are affected by RYGB surgery. Eleven patients (average age of 46 ± 4 years) were studied immediately prior to surgery and 3 months postoperatively. We measured subcutaneous adipose tissue AMPK phosphorylation (threonine 172, an index of its activation), malonyl-CoA content, protein carbonylation (a marker of oxidative stress), plasma adiponectin, and mRNA expression of several inflammatory cytokines. After surgery, AMPK activity increased 3.5-fold and oxidative stress decreased by 50% in subcutaneous adipose tissue. In addition, malonyl-CoA levels were reduced by 80%. Furthermore, patients had improvements in their BMI and insulin sensitivity (HOMA) and had increased circulating high–molecular weight adiponectin and decreased fasting plasma insulin levels. In contrast, the expression of inflammatory markers in subcutaneous adipose tissue was unchanged postoperatively, although plasma CRP was diminished by 50%. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db14-1765 hwp:master-id:diabetes;db14-1765 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3155 3159 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3160?rss=1 Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ± 1.1 kg · m–2) and 15 healthy-weight (BMI 23.4 ± 0.3 kg · m–2) older men (55–75 years old) participated in a study that determined muscle protein synthesis (MPS) and leg protein breakdown (LPB) under postabsorptive (hypoinsulinemic-euglycemic clamp) and postprandial (hyperinsulinemic hyperaminoacidemic-euglycemic clamp) conditions. Obesity was associated with systemic inflammation, greater leg fat mass, and patterns of mRNA expression consistent with muscle deconditioning, whereas leg lean mass, strength, and work done during maximal exercise were no different. Under postabsorptive conditions, MPS and LPB were equivalent between groups, whereas insulin and amino acid administration increased MPS in only healthy-weight subjects and was associated with lower leg glucose disposal (LGD) (63%) in obese men. Blunting of MPS in the obese men was offset by an apparent decline in LPB, which was absent in healthy-weight subjects. Lower postprandial LGD in obese subjects and blunting of MPS responses to amino acids suggest that obesity in older adults is associated with diminished muscle metabolic quality. This does not, however, appear to be associated with lower leg lean mass or strength. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db15-0021 hwp:master-id:diabetes;db15-0021 American Diabetes Association 2015-09-01 Obesity Studies 64 9 3160 3171 http://diabetes.diabetesjournals.org/cgi/content/short/64/8/2847?rss=1 Dietary polyphenols protect against metabolic syndrome, despite limited absorption and digestion, raising questions about their mechanism of action. We hypothesized that one mechanism may involve the gut microbiota. To test this hypothesis, C57BL/6J mice were fed a high-fat diet (HFD) containing 1% Concord grape polyphenols (GP). Relative to vehicle controls, GP attenuated several effects of HFD feeding, including weight gain, adiposity, serum inflammatory markers (tumor necrosis factor [TNF]α, interleukin [IL]-6, and lipopolysaccharide), and glucose intolerance. GP lowered intestinal expression of inflammatory markers (TNFα, IL-6, inducible nitric oxide synthase) and a gene for glucose absorption (Glut2). GP increased intestinal expression of genes involved in barrier function (occludin) and limiting triglyceride storage (fasting-induced adipocyte factor). GP also increased intestinal gene expression of proglucagon, a precursor of proteins that promote insulin production and gut barrier integrity. 16S rRNA gene sequencing and quantitative PCR of cecal and fecal samples demonstrated that GP dramatically increased the growth of Akkermansia muciniphila and decreased the proportion of Firmicutes to Bacteroidetes, consistent with prior reports that similar changes in microbial community structure can protect from diet-induced obesity and metabolic disease. These data suggest that GP act in the intestine to modify gut microbial community structure, resulting in lower intestinal and systemic inflammation and improved metabolic outcomes. The gut microbiota may thus provide the missing link in the mechanism of action of poorly absorbed dietary polyphenols. ]]> 2015-07-23T12:00:57-07:00 info:doi/10.2337/db14-1916 hwp:master-id:diabetes;db14-1916 American Diabetes Association 2015-08-01 Obesity Studies 64 8 2847 2858 http://diabetes.diabetesjournals.org/cgi/content/short/64/8/2859?rss=1 Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a "thrifty" phenotype, that is, greater reductions in 24-h energy expenditure during fasting and smaller increases with overfeeding, lose less weight during caloric restriction than those with a "spendthrift" phenotype. During a weight-maintaining period, 24-h energy expenditure responses to fasting and 200% overfeeding were measured in a whole-room indirect calorimeter. Volunteers then underwent 6 weeks of 50% caloric restriction. We calculated the daily energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and waste, energy expenditure, and daily activity. We found that a smaller reduction in 24-h energy expenditure during fasting and a larger response to overfeeding predicted more weight loss over 6 weeks, even after accounting for age, sex, race, and baseline weight, as well as a greater rate of energy deficit accumulation. The success of dietary weight loss efforts is influenced by the energy expenditure response to caloric restriction. Greater decreases in energy expenditure during caloric restriction predict less weight loss, indicating the presence of thrifty and spendthrift phenotypes in obese humans. ]]> 2015-07-23T12:00:57-07:00 info:doi/10.2337/db14-1881 hwp:master-id:diabetes;db14-1881 American Diabetes Association 2015-08-01 Obesity Studies 64 8 2859 2867 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2442?rss=1 Endostatin is a well-known angiogenesis inhibitor. Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. Adipogenesis plays a critical role in controlling adipocyte cell number, body weight, and metabolic profile in a homeostatic state. Here we reveal that endostatin inhibits adipogenesis and dietary-induced obesity. The antiadipogenic mechanism of endostatin lies in its interaction with Sam68 RNA-binding protein in the nuclei of preadipocytes. This interaction competitively impairs the binding of Sam68 to intron 5 of mammalian target of rapamycin (mTOR), causing an error in mTOR transcript. This consequently decreases the expression of mTOR, results in decreased activities of the mTOR complex 1 pathway, and leads to defects in adipogenesis. Moreover, our findings demonstrate that the antiangiogenic function of endostatin also contributes to its obesity-inhibitory activity. Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. Thus, our findings reveal that endostatin has a potential application for antiobesity therapy and the prevention of obesity-related metabolic syndromes. ]]> 2015-06-23T12:00:55-07:00 info:doi/10.2337/db14-0528 hwp:master-id:diabetes;db14-0528 American Diabetes Association 2015-07-01 Obesity Studies 64 7 2442 2456 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2457?rss=1 Insulin detemir (DET) reduces glycemia comparably to other long-acting insulin formulations but causes less weight gain. Insulin signaling in the brain is catabolic, reducing food intake. We hypothesized that DET reduces weight gain, relative to other insulins, owing to increased transport into the central nervous system and/or increased catabolic action within the brain. Transport of DET and NPH insulin into the cerebrospinal fluid (CSF) was compared over several hours and after the administration of different doses peripherally in rats. DET and NPH had comparable saturable, receptor-mediated transport into the CSF. CSF insulin remained elevated significantly longer after intraperitoneal DET than after NPH. When administered acutely into the 3rd cerebral ventricle, both DET and NPH insulin reduced food intake and body weight at 24 h, and both food intake and body weight remained lower after DET than after NPH after 48 h. In direct comparison with another long-acting insulin, insulin glargine (GLAR), DET led to more prolonged increases in CSF insulin despite a shorter plasma half-life in both rats and mice. Additionally, peripheral DET administration reduced weight gain and increased CSF insulin compared with saline or GLAR in mice. Overall, these data support the hypothesis that DET has distinct effects on energy balance through enhanced and prolonged centrally mediated reduction of food intake. ]]> 2015-06-23T12:00:55-07:00 info:doi/10.2337/db14-1364 hwp:master-id:diabetes;db14-1364 American Diabetes Association 2015-07-01 Obesity Studies 64 7 2457 2466 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2467?rss=1 The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 x 10–4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 x 10–4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 x 10–10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents. ]]> 2015-06-23T12:00:55-07:00 info:doi/10.2337/db14-1629 hwp:master-id:diabetes;db14-1629 American Diabetes Association 2015-07-01 Obesity Studies 64 7 2467 2476 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2477?rss=1 Obesity, through low-grade inflammation, can drive insulin resistance and type 2 diabetes. While infiltration of adipose tissue (AT) with mononuclear cells (MNCs) is well established in obesity, the functional consequences of these interactions are less understood. Herein, we cocultured human adipose-derived stem cells (ASCs) from obese individuals with MNCs and analyzed their reciprocal behavior. Presence of ASCs 1) enhanced interleukin (IL)-17A secretion by Th17 cells, 2) inhibited -interferon and tumor necrosis factor α secretion by Th1 cells, and 3) increased monocyte-mediated IL-1β secretion. IL-17A secretion also occurred in stromal vascular fractions issued from obese but not lean individuals. Th17 polarization mostly depended on physical contacts between ASCs and MNCs—with a contribution of intracellular adhesion molecule-1—and occurred through activation of the inflammasome and phosphatidylinositol 3-kinase pathways. ASCs favored STAT3 over STAT5 transcription factor binding on STAT binding sites within the IL-17A/F gene locus. Finally, conditioned media from activated ASC-MNC cocultures inhibited adipocyte differentiation mRNA markers and impaired insulin-mediated Akt phosphorylation and lipolysis inhibition. In conclusion, we report that obese- but not lean-derived ASCs induce Th17 promotion and monocyte activation. This proinflammatory environment, in turn, inhibits adipogenesis and adipocyte insulin response. The demonstration of an ASC-Th17-monocyte cell axis reveals a novel proinflammatory process taking place in AT during obesity and defines novel putative therapeutic targets. ]]> 2015-06-23T12:00:55-07:00 info:doi/10.2337/db15-0162 hwp:master-id:diabetes;db15-0162 American Diabetes Association 2015-07-01 Obesity Studies 64 7 2477 2488


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Dozens of people gathered in downtown Binghamton for a "National Day of Prayer" observance. The day had been designated in a proclamation issued by President Obama...
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Trade24 makes sure to follow all the rules according to Halacha of which one can invest and lend money.
Posted on: July 29th, 2014Media → Radio
Yishai is joined by Voice of Israel Bureau Chief Daniel Seaman to talk about Israeli soldiers killed by an IED and also Hamas claims to having captured a soldier.
Posted on: July 28th, 2014Media → Radio
Yishai is joined by activist and founder of Palestinian Media Watch Itamar Marcus to talk about how both the Arab media skew and also with Knesset insider Jeremy Saltan and his current IDF experience.
Posted on: July 24th, 2014Media → Radio
Yishai talks about the massive amounts of armaments stored in Gaza and is joined by MK Rabbi Dov Lipman to talk about living in Israel during this time period.
Posted on: July 23rd, 2014Media → Radio
Yishai presents riveting audio where Minister Naftali Bennett blasts a BBC show host, talks about the war in Gaza, and is joined by author Daniel Lewen to talk about Israel's resilience in war.
Posted on: July 22nd, 2014Media → Radio
Yishai and Rabbi Mottle Wolfe talk about Israel being under rocket attack and users are able to feel it first-hand as an attack happens during their interview.
Posted on: July 21st, 2014Media → Radio
Yishai gives day eight updates on Operation Protective Edge including potential rockets launched towards Israel from the Sinai. He is joined by Knesset expert Jeremy Saltan to give specific government updates.
Posted on: July 18th, 2014Media → Radio
Yishai focuses on the 'silent cyber war' between Israel and Hamas, anti-anti-Semetic demonstrations in France, and talks to MK Danny Danon about his role change in the government.
Posted on: July 17th, 2014Media → Radio
Yishai gives day eight updates on Operation Protective Edge including potential rockets lauched towards Israel from the Sinai including an interview with Knesset insider Jeremy Saltan.
Posted on: July 16th, 2014Media → Radio
(((CLICK BELOW TO HEAR AUDIO))) Yishai talks about day seven of Operation Protective Edge and the use of an innovative phone app to inform those of rocket attacks from Gaza. Yishai moves on to give updates on Israel's response to Arab aggression and ends presenting audio recorded with Middle East and Arab cultural expert Dr. […]
Posted on: July 15th, 2014Media → Radio
Yishai presents audio recorded with Daniel "Danny" Seaman, who is the Deputy Director General for Information at the Israeli Ministry of Public Diplomacy and Diaspora Affairs to discuss the Arab reaction to events that have happened in the past couple of weeks.
Posted on: July 14th, 2014Media → Radio
Yishai is joined by security expert Marc Prowisor to talk about the situation and how the lack of action is actually causing more violence in the country.
Posted on: July 10th, 2014Media → Radio
Yishai is joined by Knesset insider Jeremy Saltan to talk about the situation in the government including the dissolving of the Likud-Beiteinu coalition and also preparing for an operation in Gaza.
Posted on: July 9th, 2014Media → Radio
Yishai and Malkah kick off this week's show talking about the current situation in Israel and how things are tenser in the Fleisher's neighborhood in Jerusalem
Posted on: July 8th, 2014Media → Radio
Yishai presents audio recorded with Dr. Mordechai Kedar during a recent conference, the topic of Dr. Kedar's talk was looking at shame and honor in Arab societies.
Posted on: July 7th, 2014Media → Radio
Malkah broadcasts from Ramat Beit Shemesh and is joined by celebrity Kosher chef and personality Jamie Geller to talk about the Geller's move to Israel and insight to the then-missing teens.
Posted on: July 3rd, 2014Media → Radio
Yishai is joined by Knesset Insider Jeremy Man Saltan to talk about the disappearance and murder of the Israeli teens including a government perspective that has not been heard on public airwaves.
Posted on: July 2nd, 2014Media → Radio
Yishai and Malkah talk about specifics behind finding three murdered Israeli teens and also Makah's experience having to tell the Fleisher's daughter about what happened to the teens.
Posted on: June 30th, 2014Media → Radio
Yishai is joined by Knesset insider Jeremy Man Saltan to talk about the feeling in the Israeli government and their response to the three Israeli abductees that are being held by Hamas.
Posted on: June 27th, 2014Media → Radio
Yishai and Malkah talk about the continued search for three missing Israeli teens, an innocent Israeli youth killed on the Syrian border, and comedy for Koby.
Posted on: June 23rd, 2014Media → Radio
Yishai presents wonderful audio that he recorded while teaching a class about the Book of Ruth to students at Yeshiva HaKotel.
Printed from: http://www.jewishpress.com/tv/radio/a-man-who-brings-students-to-israel-and-a-revolutionary-rabbi-brigadier-general/2015/04/09/
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Theatre Of Widdershins: The Elves & The Shoemaker, Monday 14th Sep, Read more
This lovely family show will be touring all over the UK from September 2015 to August 2016. Please check our website for details of where we will be.
Puppetry and Storytelling for the whole family. We tour the UK shaking up traditional tales with pop up sets, amazing puppets and a gorgeous soundtrack.
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Schalke penalty appeal v Arsenal. Did Mannone bring down Afellay?
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As Texhnolyze was created by many of the artists who produced Serial Experiments Lain, it's not surprising that the story unfolds in fragments. Trying to adjust to his incomplete cybernetic limbs, Ichise stumbles through the grubby streets and sewers of Lukuss. Ran follows him mutely, sometimes wearing a fox mask, which is traditionally associated with shape-shifters. The mysterious doctor who began the transplants completes the job, sheathing the skeletal metal and improving Ichise's coordination. Yoshii the wanderer precipitates a war between the rival gangs of Organo and the Salvation Union to observe the "raw energy" it unleashes. The bleak atmosphere feels more important--and interesting--than any of the characters. Fans of Lain may find Texhnolyze profound and compelling; its detractors will dismiss it as pretentious hokum. Few viewers will regard it with indifference. (Rated 16 and older: considerable violence, nudity, sexual situations, alcohol and tobacco use) --Charles Solomon
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Publications (4)8.25 Total impact
Article: Measuring HPV vaccination coverage in Australia: comparing two alternative population-based denominators[Show abstract] [Hide abstract]
ABSTRACT: To compare the use of two alternative population-based denominators in calculating HPV vaccine coverage in Australia by age groups, jurisdiction and remoteness areas. Data from the National HPV Vaccination Program Register (NHVPR) were analysed at Local Government Area (LGA) level, by state/territory and by the Australian Standard Geographical Classification Remoteness Structure. The proportion of females vaccinated was calculated using both the ABS ERP and Medicare enrolments as the denominator. HPV vaccine coverage estimates were slightly higher using Medicare enrolments than using the ABS estimated resident population nationally (70.8% compared with 70.4% for 12 to 17-year-old females, and 33.3% compared with 31.9% for 18 to 26-year-old females, respectively.) The greatest differences in coverage were found in the remote areas of Australia. There is minimal difference between coverage estimates made using the two denominators except in Remote and Very Remote areas where small residential populations make interpretation more difficult. Adoption of Medicare enrolments for the denominator in the ongoing program would make minimal, if any, difference to routine coverage estimates. © 2015 Public Health Association of Australia.Australian and New Zealand Journal of Public Health 06/2015; 39(4). DOI:10.1111/1753-6405.12372 · 1.98 Impact Factor
Article: Assessing HPV vaccine coverage in Australia by geography and socioeconomic status: are we protecting those most at risk?[Show abstract] [Hide abstract]
ABSTRACT: Objective: To determine whether HPV vaccine coverage in 12-13-year-olds varies by geographical area, remoteness and ecological level indicators of socioeconomic status (SES). Method: Data from the National HPV Vaccination Program Register (NHVPR) were analysed at Statistical Local Area (SLA) level, by the Index of Relative Disadvantage (IRSD) and the Australian Standard Geographical Classification Remoteness Structure. Results: Nationally, 73% of females aged 12-13 years in 2007 were fully vaccinated against HPV. Coverage in low SES areas (71.5%) was 4.1 percentage points lower than coverage in high SES areas (75.6%). Uptake of the first two doses was higher in the very remote parts of Australia (dose 1 - 88.5%, dose 2 - 81.8%) than in major cities (dose 1 - 83.4%, dose 2 - 80.2%), but not for dose 3 where coverage in major cities was 3% higher (73.6% versus 71.4%). Conclusion: Notifications of HPV vaccine doses delivered to females aged 12-13 through schools suggest a high and relatively equal uptake across socioeconomic groups. Females in remote regions have the highest uptake of dose 1 but are least likely to complete the course. This may be due to particular challenges in vaccine delivery to residents of remote areas.Australian and New Zealand Journal of Public Health 06/2014; 38(5). DOI:10.1111/1753-6405.12218 · 1.98 Impact Factor
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ABSTRACT: We analysed human papillomavirus (HPV) vaccination coverage from the 2007-2009 catch-up program for women aged 18-26 years by Division of General Practice (DGP), alongside a survey about under-notification. Coverage rates were calculated from the National HPV Vaccination Program Register. An online survey of immunisation coordinators in DGP assessed under-notification. HPV vaccine coverage by DGPs varied greatly: dose 1, 22-70%; dose 2, 13-60%; dose 3, 7-49%. Most coordinators (38/52, 66%) believed that more than 80% of practices notified the register. Perceived notification barriers included being busy, not knowing how to notify, not obtaining consent, insufficient remuneration and delay in register establishment. DGP coverage varied widely. Process barriers (time and resource limitations) probably contributed to under-notification, with informational barriers (unaware how to notify) and motivational barriers (not worth the effort) secondary to this. Differences in reported coverage between DGPs and states reflect both differences in notification rates and underlying HPV vaccine coverage.Australian family physician 12/2013; 42(12):880-4. · 0.71 Impact Factor
Article: Human papillomavirus vaccination and cervical cancer screening by socioeconomic status, VictoriaThe Medical journal of Australia 04/2012; 196(7):445. DOI:10.5694/mja11.11360 · 4.09 Impact Factor
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IELTS Speaking test in Malaysia – April 2013
Hey, you're new here! I love new people, welcome.
You may want to subscribe to IELTS-Blog and get all the updates via email or via RSS feed. Thanks for visiting!
The speaking questions below were shared by an IELTS test taker from Malaysia (thanks L!).
- What is your full name?
- Can I see your ID?
- Where are you from?
- Where do you stay?
- Do you work or study?
- What do you do for a living (what job)?
- What is the most interesting place in the city that you would recommend to visit?
- Do you think gardens are important for people in the city area?
- What kind of building design is popular now?
- Would you like to be an architect, if you had a chance?
Cue Card
Describe a seminar or a speech that you have attended. Please say
- What kind of seminar/speech was it?
- Where was the seminar/speech held and who was the speaker?
- Was it helpful for you in some way?
- Why do people get nervous when they speak in public?
- How can they improve their public speaking skills?
Related posts:
- IELTS test in Penang, Malaysia – April 2015 (Academic Module) Our kind friend T took the IELTS test in Malaysia...
- IELTS Speaking test in Malaysia – September 2014 Thanks to D who took the IELTS test in Malaysia...
- IELTS Speaking test in Malaysia – June 2015 Our friend M who took the IELTS test in Malaysia...
- IELTS test in Mongolia and Malaysia – April 2015 (Academic Module) Two IELTS test takers from Mongolia and Malaysia (thank you,...
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Last Thursday my son, Ethan, and I put up our Christmas tree. It was fairly simple – fit tab A into slot B and so forth. I've never had an artificial tree before, so this was a new experience.
After the metal pieces had been slotted, we stood back and Ethan said, "Mom that doesn't look like the box." I assured him that the metal branches extending from the metal trunk could be covered with cuttings from our cedar tree outside – not to worry.
I was worried. It looked like a Charlie Brown Christmas tree.
Then I studied the box again and noticed that the tree limbs were on hinges and could be bent out. It took a little time to do, but by the time I had bent the hinges, the tree looked like the box. Came with lights, too.
The next day, I strung some colored lights on it, and thought that later that evening we could begin to hang ornaments.
Enter my twin 4-year-old granddaughters, Amy and Kaylee. Daddy brought them to Grandma's house for a visit, and after they had explored their toy room and sat for a while in the "princess reading corner," they started looking for something else to do.
That was when they noticed the Christmas tree in the front room. "Can we help you decorate the tree, Grandma?" they asked. Of course, Grandma said "Yes."
I must admit, I was a little nervous. Beginning with non-breakable ornaments, soon the only ones left to hang were the precious glass ornaments that I had accumulated over a number of years.
Handing one of the special ornaments to Kaylee, she advised me, "You have to bend this over, Grandma, so they will hang on the tree."
That was when I realized that my little ones were veterans of Christmas tree decorating. Our tree soon sparkled with the various colors of ornaments, all hanging from the lower branches.
I don't know about you, but my childhood memories of Christmas tree decorating come with mixed feelings.
Six children and one tree can cause problems. It seems that the expectation surrounding the presence of the Christmas tree in our home clouded the memories of the previous Christmas tree decorating fiasco.
To my memory, the happiness of beginning to decorate the tree soon evaporated as we hurried to see who could hang the most ornaments on the tree. In our rush, the smaller children would sometimes be pushed aside, stepped on or generally ignored, at which time they protested loudly.
After the crying children were soothed and the spankings meted out, Mom would unwrap the angel tree-topper. The angel was always the last ornament to be added to the tree. If dad wasn't at work, it was he who would anchor the angel on the tree, signifying that tree decorating was done.
The Christmas trees of my youth were much like the tree pictured above in my 1955 family Christmas photograph. Looks like my brothers, sister and I were satisfied with our gift that year. Funny, I do not remember the doll, but remember well the watch and cufflink case my eldest brother, Ed, is shown holding.
This year, as I held my tree-topper in my hands before placing it on the highest branch, memories flooded back and I wished it was my mother's little angel topper that I held. But then again, I have my own little angels in Amy and Kaylee.
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The Watcher in the Woods Is a Generation's Halloween Nightmare
Scary Bette Davis.By Rakesh Satyal
Scary Bette Davis.By Rakesh Satyal
"Old age ain't no place for sissies."By Julie Ma
Reminiscing about the good old days of matching pinstripe sofas.By Maggie Lange
From Hathaway to Britney, Cleopatra, and Christian saints.By Rebecca Harrington
Even the light seems cut with razor blades.
The 'Gossip Girl' star spent a party in her honor on her BlackBerry, and more bad behavior in our daily gossip roundup.By Tim Murphy
A terrific set of six discs that includes her fiery performances in All About Eve, Hush Hush Sweet Charlotte, and The Nanny.
Yep, more Kanye.


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Rachael makes her own rice pilaf to add to her Make-Ahead Paella Casserole.Watch Video
Rachael stews her Mexican pork in a nut, raisin and ancho chile puree.Watch Video
Freeze these pork-prawn won tons, then boil and serve when you're ready.Watch Video
Make Roman-Style Chicken in advance to heat up when you're ready to eat.Watch Video
Rachael shows how one ingredient can help build a week's worth of meals.Watch Video
Holy chipotle! Get ready to pig out on Rachael's spicy, smoky pork tacos.Watch Video
This comfort-food-times-two is a great way to stretch expensive crabmeat.Watch Video
Take a chance on Rachael's Eggplant-Ricotta Lasagna. You won't regret it.Watch Video
Casserole goes Latin: layers of sauce, tortillas, chicken and cheese.Watch Video
You can make Rachael's chicken pot pie at the drop of a hat -- or biscuit.Watch Video
Kelsey Nixon reveals dishes to make ahead and freezes for Thanksgiving.
See how you can grill chicken breasts on Sunday to make lunches all week.
Fire up the grill for an anything-but-ordinary summertime fruit dessert.
Rachael shares memories of her grandpa and describes his influence on her.
Individual meatloaves of turkey and stuffing make any day Thanksgiving.
Rachael's quick tip guarantees perfect hard-boiled eggs every time.
Vibrant chimichurri adds just the right touch to steak-and-chorizo chili.
Dazzle your guests with a quick and easy pear appetizer.
Rachael serves Pork Tenderloin Posole over a bottom-of-the-bowl surprise.
Make Roman-Style Chicken in advance to heat up when you're ready to eat.
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Jan 13, 2014
Waterloo, ON – BlackBerry® Limited (NASDAQ:BBRY; TSX:BB), a world leader in mobile communications, today announced that Eric Johnson will join the Company as President, Global Sales reporting to BlackBerry's Executive Chair and CEO, John Chen.
"I am pleased to round out BlackBerry's new executive leadership team with another outstanding addition today. I have worked with Eric extensively and have tremendous respect for his sales expertise and customer centric approach to business. Our carriers, partners, distributors and enterprise customers will benefit greatly from Eric's approach," said Chen. "The experience that the majority of the new leadership team has in working together previously will drive change within the organization at a faster pace. I look forward to demonstrating these changes to the market."
Eric Johnson most recently served as Senior Vice President and General Manager for SAP's Global Database and Technology. Prior to that, Eric was Senior Vice President and General Manager of Platform and Analytics Sales for North America, also at SAP. In the years preceding, Eric served in several capacities at Sybase, including Senior Vice President and General Manager for North America, Senior Vice President and General Manager Europe, Middle East and Africa, and Senior Vice President and General Manager for Financial Services, where he managed both direct and indirect sales including field sales, professional services and customer services. Eric holds a Bachelor's degree in Political Science from the University of Wisconsin-Madison.
About BlackBerry
A global leader in mobile communications, BlackBerry® revolutionized the mobile industry when it was introduced in 1999. Today, BlackBerry aims to inspire the success of our millions of customers around the world by continuously pushing the boundaries of mobile experiences. Founded in 1984 and based in Waterloo, Ontario, BlackBerry operates offices in North America, Europe, Asia Pacific and Latin America. The Company trades under the ticker symbols "BB" on the Toronto Stock Exchange and "BBRY" on the NASDAQ. For more information, visit www.blackberry.com.
Forward-looking statements in this news release are made pursuant to the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995 and applicable Canadian securities laws. When used herein, words such as "expect", "anticipate", "estimate", "may", "will", "should", "intend", "believe", and similar expressions, are intended to identify forward-looking statements. Forward-looking statements are based on estimates and assumptions made by BlackBerry Limited in light of its experience and its perception of historical trends, current conditions and expected future developments, as well as other factors that BlackBerry believes are appropriate in the circumstances. Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward-looking statements, including those described in the "Risk Factors" section of BlackBerry's Annual Information Form, which is included in its Annual Report on Form 40-F (copies of which filings may be obtained at www.sedar.com or www.sec.gov). These factors should be considered carefully, and readers should not place undue reliance on BlackBerry's forward-looking statements. BlackBerry has no intention and undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
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Sydney Leroux
Sport: Soccer
Position: Forward
Height: 5'7"
Current Residence: Seattle, Wash.
College: UCLA
- 2012 Olympic Experience, gold medal
- Two-time FIFA U-20 Women's World Cup team member (2008, 2010)
- 2008 FIFA U-20 Women's World Cup, Golden Ball winner
- 2008 FIFA U-20 Women's World Cup, Golden Shoe winner
Fun Facts: Mother, Sandi, is Canadian and played third base for the Canadian National Softball Team...Father, Ray, played professional baseball...Has 13 tattoos....Hobbies include shopping, listening to music, running and practicing yoga.
Learn more:
US Soccer Bio
U.S. Olympic Committee Announces Best Of July Honors For Team USA Awards Presented By Dow
United States Olympic Committee Aug. 07, 2015
Carli Lloyd, Sam Mikulak and the U.S. Women's National Soccer Team earn July accolades.
Vote On Team USA's Top Athletes From July
Aug. 03, 2015
See which athletes made Team USA's Best of July nominations and vote on your favorites.
Team USA Wins First Women's World Cup Title In 16 Years
Associated Press July 05, 2015
The U.S. women's soccer team scored its third Women's World Cup title with a 5-2 win over Japan.
Most Superstitious? Best Singer? Get To Know The U.S. Women's Soccer Team
Lisa Costantini July 05, 2015
Carli Lloyd reveals six things about her Women's World Cup teammates.
Six #USWNT Accounts To Follow During The Women's World Cup
June 08, 2015
From hilarious to inspirational, here are six women to watch on social during the FIFA Women's World Cup.
Canadian-Born Sydney Leroux Ready To Face The Fans At Women's World Cup
Brian Trusdell June 07, 2015
Born in Canada, Leroux knows she won't be a fan favorite at the tournament there.
Soccer Legend Kristine Lilly Weighs In: What Will It Take For The U.S. To Win The FIFA Women's World Cup?
Peggy Shinn May 26, 2015
The three-time Olympic medalist analyzes the U.S. roster for the FIFA Women's World Cup.
Ellis Names U.S. Roster for 2015 FIFA Women's World Cup Team
U.S. Soccer April 14, 2015
U.S. captain Rampone will compete in her fifth Women's World Cup, leading a team that includes 14 Olympians.
USA-Portugal Through The Tweets Of Olympians
June 22, 2014
See how members of Team USA reacted to Sunday's game >>
Social Media Stories: Team USA Selfies
U.S. Olympic Committee Nov. 25, 2013
Team USA athletes celebrate the word of the year with their best selfies
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Company Overview of Saltare
Company Overview
As of October 15, 2002, Saltare was acquired by Vizional Technologies Inc. Saltare provides a Java-based, Web-centric software solution to link real-time supply chain information with decision-making tools. Its software application is called Leap!. Its functionality allows buyers to monitor the status of their supply shipments and to receive notification of problems with their supply deliveries. Saltare.com was formed in 1998 by Dr. Marco Gagliardi and Dr. Cosimo Spera. The company is based in San Mateo, California.
2755 Campus Drive
Suite 255
San Mateo, CA 94403
United States
Founded in 1998
Key Executives for Saltare
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Granite stela of Peribsen
From Abydos, Egypt
2nd Dynasty, around 2800 BC
One of a pair which stood at the entrance to the king's tomb
While the kings of the First Dynasty (about
3100-2890 BC) were buried at Abydos, the first kings of the Second
Dynasty (about 2890-2686 BC) were buried at Saqqara. However, the
last two kings, Peribsen and Khasekhemwy, chose to be buried at
Abydos alongside the First Dynasty kings. Peribsen erected
The rectangle
containing the
More information
A.J. Spencer, Catalogue of Egyptian antiqu-4 (London, The British Museum Press, 1980)
S. Quirke and A.J. Spencer, The British Museum book of anc (London, The British Museum Press, 1992)
Height: 113.500 cm
Width: 33.000 cm
Height: 113.500 cm
Museum number
Gift of the


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A sneak preview of an upcoming documentary that goes behind the scenes at a community theater production of A Christmas Carol, from the initial auditions to the final performance, capturing all of the backstage struggles and antics in between.
live streaming schedule & on demand videos
|07:30 pm
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|03:00 pm
|Glenn Korff School of Music: Symphony Orchestra, Kimball Recital Hall
|07:30 pm
|Glenn Korff School of Music: Big Red Singers and Vocal Jazz, Kimball Recital Hall
|The Omaha News: February 25, 510
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|Pat Loontjer of the group Gambling with the Good Life talks about her efforts against expanded...
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|The engines of the U. S. economy rely on entrepreneurship, technology, and innovating new products...
|Backyard Farmer Presents: Lifestyle Gardening: Tomato Diseases and Bulbs in Bloom, 205
|This program looks at tomato diseases and care of bulbs that have started to bloom.
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|Learn about the basic, appropriate ways to greet people and how to act in public and at work.
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|Sen. Paul Schumacher of Columbus discusses initiative petitions, gambling, and legislative...
|Lost Writers of the Plains: Novelist Timothy Schaffert talks about Krause's family setting as he grew up.
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|Lost Writers of the Plains: Historian Bill Pratt discusses people on the road in the early 1930s
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Fall Quarter 2015 GFIS Workshops
Don't let funding application deadlines pass you by! These Graduate Funding Information Service (GFIS) workshops introduce current UW graduate students (Masters and PhD) to resources for finding fellowships, scholarships, grants, and employment to help finance graduate education, research, and travel. Each workshop provides an overview of databases and search strategies for finding funding, as well as the timeline for applying for fellowships and grants. A variety of times and formats (face-to-face or webinar) are offered. The workshop on October 8th will specifically address international students, though international students are welcome at any of the other sessions.
Workshop: Finding Funding for Grad School
Tuesday, October 1, 2015 @ 12:00 pm, Research Commons, Green A
International Students: Finding Funding for Grad School
Thursday, October 8, 2015 @ 12:00 pm, Research Commons, Green A
Webinar: Finding Funding for Grad School
Tuesday, October 13, 2015 @ 3:00 pm, AdobeConnect
Workshop: Finding Funding for Grad School
Wednesday, November 18, 2015 @ 1:30 pm, Research Commons, Green A
Further workshop details can be found on the Research Commons' event calendar.
GFIS is happy to provide departmental workshops and presentations for graduate programs at UW! If you'd like to discuss a workshop idea you have, or just want GFIS to come speak to students in your department, please send us an email at email@example.com


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Small group (25) customized tour visiting WWII sites with private guide. First-class hotels in Berlin, Dresden, Bamberg, Munich, Salzburg, & Vienna. Sept.27-Oct.8, 2012
A two week tour of the Central European Alps, where a van carries all your luggage, BMW motorcycles are furnished, and you are free to ride at your own pace on your own route!
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A 2 week tour of the Eastern European Alps, where a van carries all your luggage, BMW motorcycles are furnished, and you are free to ride at your own pace on your own route!
The Alpine Sampler is a week of great rides, postcard-perfect scenery and excellent accommodation.
Self-guided hiking vacations for the independent traveller to some of the most magnificent and diverse landscapes of Germany, Austria, Switzerland, the Italian Dolomites and South Tyrol with Touching Nature Travel.
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Landsberg, Germany visitors guide to accommodations, adventure travel, unique tours and rentals. Check out top Landsberg, Germany getaways & destinations. Landsberg, Germany vacations, packages & travel spots. Visit Landsberg, Germany !.


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North Carolina polls are open for early voting in the primary election, and the rights of unmarried couples are being put to a public referendum.
The Defense of Marriage Act denies a host federal benefits to those gay and lesbian couples who have legally married in DC and the six states that recognize same-sex marriage. Yesterday, the Senate Judiciary Committee held hearings on a repeal of that discriminatory law.
Some opponents of same-sex marriage sound rational when they offer civil unions as a substitute for marriage but marriage by any other name is not the same. Our society can't hold out marriage as this ideal and then withhold it from some–even if it is in name only. We tried separate but equal and we all know it isn't equal.
"Pro-family" group, Focus on the Family is shifting away from opposing same-sex marriage and instead focusing on making it more difficult to obtain a divorce. Does anyone else think this is scary? …
When the Politics of Hate Comes Home: A Lesbian Couple Grapples with How Politics Affects Their Critically-Ill Child
Jaime and Laura are a lesbian couple in California whose son suffers from a serious heart condition. Without legal protections, their family would have suffered far more hardship than they did. Jaime addresses supporters of Prop 8 in a letter.
Same-sex marriages won't be allowed in California during Prop 8 appeal, international transgender news, trade schools cannot discriminate against applicants with HIV or AIDS, and Virginia pro-choice groups ask for new regulations to be applied to all outpatient surgery centers, not just abortion clinics.
Michigan and Maryland's slew of anti-abortion bills, trends in banning insurance coverage of abortion, Arizona voting on race and sex abortion ban, Bobby Franklin says something crazy, and Sen. Feinstein introduces repeal of the Defense of Marriage Act.
New Hampshire does not want to repeal its marriage law, Nebraska may increase family planning funding, the elimination of Title X, young moms need career support, and Republican use of abortion as political manipulation.
Judge Vaughn Walker, the man behind the overturning of California's Proposition 8, which would have outlawed same-sex marriage, is giving supporters of the proposition one more week to seek a permanent stay. If not, same sex couples are free to marry in California as soon as August 18th.
Elena Kagan has been confirmed by the Senate as our next Supreme Court Justice.


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News SFX Releases The Ultimate Guide to Anime
posted on 2011-05-27 05:56 EDT
SFX has released The Utimate Guide to Anime in stores today. The cover price is £7.99 and the magazine is 132 pages incuding covers. In addition to the printed magazine, each copy comes with a copy of the first 3 episodes of The Sacred Blacksmith on DVD, a set of Naruto Shippuden fridge magnets and a double sided posted featuring Summer Wars and the Girl Who Leapt Through TIme.
The Ultimate Guide to Anime features articles about studio Bones, The Girl Who Leapt Through Time, the new re-release of Akira, among others.
This is the fifth anime special published by SFX over the years.
Disclosure: ANN UK editor Andrew Osmond contributed to the SFX Ultimate Guide to Anime. Osmond did not write or edit this news article, although he did provide information.
The Fall 2015 Anime Preview Guide
Available Now: The Perfect Insider - Anti-Magic Academy - Dance with Devils - Beautiful Bones: Sakurako's Investigation - Yuru Yuri 3rd Season - Mr. Osomatsu - STARMYU - One-Punch Man - Concrete Revolutio - and much more! ― Welcome to Anime News Network's Fall 2015 Preview Guide! Here's h...


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From fresh white palettes to ultra-thick knits to the whimsically romantic, discover fall's most enchanting new trendsRead More »
Denim Obsessions
From ladylike details to retro vibes, our VP of Womenswear, Terence Bogan, shares the season's hottest denimRead More »
5 Minutes With Kenzo
This fall, the designer duo behind Kenzo created an exclusive line of products for Holts. We chat with the pair about how they got startedRead More »
New At Holts: Pre-Fall Essentials
We're transitioning through the seasons with some key designer introductions. Meet the six new brands you'll be obsessing over this fallRead More »
Summer Office Style
From morning meetings to patio cocktails, stay cool in office-appropriate looksRead More »
Pool Hopping
Hitting the beach or lounging poolside, make a splash in the perfect swimsuitRead More »
5 Minutes With ATM
We chat with the seasoned vet about his latest venture, the lure of a perfect tee and being ahead of his timeRead More »
A Toast to the CFDA Nominees
The nominees, presenters, the whole nine yards, here's everything you need to know about this year's CFDA AwardsRead More »
The Romantics
Navigate wedding season like a pro with our edit of vibrant dressesRead More »
Fresh Coat
Our VP of Womenswear, Terence Bogan rounds up the season's best lightweight layersRead More »


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Dan Murphy just started a new company called Proof which has some cool t-shirts, beanies, hats, and hoodies. Check out the goods inside.
New Clothing Company Proof
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Obviously inspired by Ninja-Supremes' Things everybody likes that you don't thread.
So yeah, things everybody hates that you don't?
For me, it's the Twilight -book.- I've never seen the movie, but I hate it it. I also hate fangirls. But the book, I must admit, is good..
Hmmm.. I'm sure theres some other things as well- But I can't think about it right now.


text:
BSD Medical Corp. (BSDM) Sells Batch Of MicroThermX® System To Turkey's ADA Medikal 0 commentsJan 14, 2013 5:20 PM | about stocks: PRSN
BSD Medical has sold several of its MicroThermX® Microwave Ablation systems and antennas to ADA Medikal in accordance with the companies' exclusive distribution agreement signed in October 2012. Financial details of the transaction were not disclosed.
The MicroThermX is a compact, mobile, proprietary system that includes a microwave generator, single-patient-use disposable antennas, and a thermistor-based temperature monitoring system. The U.S. Food and Drug Administration (FDA) previously granted BSD Medical a 510(k) clearance to market the system for ablation of soft tissue; BSD Medical has also received CE Marking for the system, allowing marketing of the device in Europe.
ADA Medikal, a medical specialty distributor in Turkey, anticipates that it will need to order a "significant number of systems" to address the market for the MicroThermX in Turkey.
BSD Medical focuses on the development, manufacture, marketing, and service of systems to treat cancer and benign diseases using heat therapy delivered using focused radiofrequency (NYSE:RF) and microwave energy. The company's product lines include both hyperthermia and ablation treatment systems.
BSD Medical stock climbed following the news, with shares up nearly 4% by mid-day, trading at $1.63.
For more information visit BSDMedical.com
Please see disclaimer on the QualityStocks website: disclaimer.qualitystocks.netStocks: PRSNBack To QualityStocks' Instablog HomePage »
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.Full index of posts »
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Reviews written by registered user
|2 reviews in total
The April 13, 1970 issue of the French weekly magazine L'Express
published a review of Claude Berri's Le Pistonée written by François
Truffaut.The lead-in for that review details that Truffaut had asked
the magazine for a chance to write something about the film and it
describes Truffaut and Berri as "friends and colleagues". In the mid
1960s, Truffaut had devoted part of his time to helping young
filmmakers raise money to make their films and he had taken Berri on as
his main assistant in this enterprise. This began a close friendship
that would only end with Truffaut's death. A reading of Berri's memoir
Autoportrait published in 2003 leaves one to realize that some 20 years
later Berri was still in mourning. In early 1971, when upon its release
Le Cinéma De Papa was severely criticized by the Paris critical
establishment, including the dean of French film critics at the time Le
Monde's Jean De Baroncelli and the new chief critic,Gilles Jacob, at
L'Express, Truffaut went to Pariscope and penned an article defending
the film. In the mid 1970s, Truffaut published a collection of his film
reviews entitled The Films in My Life and in a chapter labeled "My
Friends in the New Wave", he reprinted that review. I believe that it
is fitting and necessary that I file that review as it was translated
by Leonard Mayhew for the English edition of Truffaut's book
"After Le Vieil Homme et L'Infant, which I adored, Le Cinema De Papa is probably Claude Berri's best film. If its title gives the impression that it is a film about films, the truth is that Le Cinema is really concerned with the most basic elements of life itself, precisely those things that current films mostly avoid: the struggle to earn a living, money problems, daily bread, the search for a trade, the birth of a vocation, the alternation of good and bad luck. "The humanity of Charlie Chaplin's films is made of the same stuff: the necessity of three meals a day, to find work, to be happy in love. These are the best themes, the most simple and universal. Curiously, to the degree that cinema becomes more intellectual, they are the most ignored. Berri's films never whine; his characters never accuse anyone else of being to blame for their troubles; they believe in chance and luck, but even more in energy. I find this energy in Berri himself, in his work, in his personality, in his life. Cinema requires poetry, sensitivity, intelligence, and whatever, but even more imperatively it needs vitality. "Berri isn't one of those directors who are in love with cinema; he doesn't refer to other films but to life itself. He draws from the source. Like Marcel Pagnol and Sacha Guitry, who are seriously underestimated in their time, Claude Berri first of all has stories to tell. He feels them so strongly that he quite naturally invents and discovers the best forms to communicate them. When he told me about his plans to shoot Le Cinema De Papa, I told him to have someone screen Le Roman d'UN Tricheur and Le Schpountz for him. "But since he prefers good meals and conversations with friends, he never took the time and he was right, because his storyteller's instinct led him to the best solution of the problems the film posed. "I want to draw your attention to an especially original aspect of Le Cinema De Papa. We know by definition artists are, if not antisocial, generally asocial. Before they criticize society at large, they have already been at odds with their families who did not understand them, or who oppressed them. Their vocation is often born of a wound. In Le Cinema De Papa, and in all of Berri's films, it is just the opposite; the basis of his credo could be "My family I love you". When you come out of this movie, you are sure that Claude Berri is not scared in the way of artists who are cut off from their families. Here is a filmmaker who loves his parents. It makes his film even more unusual." In his 2003 memoir, Berri, on different occasions quotes large chunks of this review. On page 204 of that memoir, Berri wrote, "The last time I telephoned François to ask him if I could come and visit him, he answered me, 'But you know well, my dear Claude, that it would still be a pleasure to see you before croaking'. He pressed me to re-release Lubitsch's films, to read Bazin's articles on Pagnol, encouraging me to film Jean De Florette. He wanted me to arrange a private screening of Amadeus for him." Unfortunately, while Berri did set up the private screening of Amadeus, Truffaut was not physically up to attending and he died soon after. On page 284, Berri wrote, "21 October, the same year [1984], the death of François Truffaut. At his interment, in the cemetery in Clichy, all those who had loved the man who loved women were there crying."
One often sees the criticism of Francois Truffaut"s "Le Dernier Metro"
( "The Last Metro") that he had turned to making films in the tradition
of the films that he had scorned as a young critic in the 1950s. Of
course, most of these writers are not familiar with the films that he
had scorned. I would say "yes" he was working in a tradition. He could
almosthave titles the film "Si Paris occupeé nous était conté". Sacha
Guitrywas one of his heroes. But he did call the film "Le Dernier
Metro" and that title points to the tradition of the film and explains
its style.It is true that the early scene where Bernard tries to pick
up Arlette bears some resemblance to the scene at the beginning of "Les
Enfants des Paradis" in which Frederick attempts to pick up Garance. It
must be remembered though that the young critics of the 50s had no ax
to grind with the Prevert-Carne films of the late 30s and the first
half of the 40s. Anyone who watches the clip of Godard from 1963 on the
"Bande a Part" will hear him praise the Carne of "Quai des Brumes"
before deprecating the Carne of "Les Tricheurs". Even their criticism
of Carne that merely photograph his screenwriters scenario, that he was
more a "metteur en image" than a "metteur en scene", had started in the
mid-40s by Henri Jeanson, Carne's one-time collaborator. But getting
back to my point that scene occurring in the midst of the crowd on the
Boulevard des Crime in the Carne film explains its title and
theme.Carne's film is about theater-goers, even his four
theatricalprotagonists all attend plays. Truffaut's film though is not
so muchabout the audience as it is about the theater world and hence
its title" Le Dernier Metro". Before I get back to my point I believe I
should note here that "Le Dernier Metro" was meant to be one panel in a
trilogy on the entertainment world. "La Nuit Americaine" ("Day for
Night") was of course the film panel. And "L'Agence Magique" a film
about Music Hall was never made. In the late 70s Truffaut had a
screenplay for this film ready to shoot and had begun pre-production
but the failure of "The Green Room" caused him to alter his plans and
to film "L'Amour en Fuite".
The voice-over prologue describes an occupied Paris where night workers have to scurry to make the last metro in order to beat the curfew. What is left to our imaginations is to realize that many of these workers are theater people. Jean Marais whose real-life thrashing of the Je Suis Partout drama critic Alain Laubreaux provided the inspiration for one of the key scenes in the film described the last metro thusly in his autobiography "Histoires de ma Vie" (page 159)
"The last metro was marvelous. As packed as the others. It carried all of the theater world of Paris. Everyone knew everyone else. We spoke of the latest concert, of the ballet, of the theater. Outside, it was the blackout, the militias, German patrols, hostages if one was out past curfew." NOTE: "Tout-Paris" usually means " Paris high society" but Marais in the book frequently uses in a narrower sense of "the theater world".
In other words "Les Films de Carosse" had produced a film that represented "the last metro" as the golden coach of occupied Paris. Some quarter of a century earlier before Truffaut made "Le Dernier Metro" he with Jacques Rivette had interviewed Jean Renoir and Renoir told them that in order to do his film on the world of theater "The Golden Coach" he had found it necessary to subordinate his style to a theatrical style. Could it be that there is one explanation of the style of the film? So now Truffaut was returning to the style of "The Golden Coach".
Some other ideas gleaned from Nestor Almendros' "A Man With A Camera". Remember the scene from the beginning of the film that I spoke about earlier, the one were Bernard accosts Arlette. I can still remember the feeling of claustrophobia that I felt the first time I saw "Le Dernier Metro". And of course I was going to soon discover that one of the main characters in the film was hiding in a small room in the basement of his theater. Almendros speaks of using the camera to create a feeling of claustrophobia in this film. He also reveals that it was normal for Truffaut to keep his windows open. But in this film because of its theme and its time period, windows remained shut. Also, he and Truffaut wanted the look of early Agfacolor of films like "Munchhaussen" and "Die Goldene Stadt". A look that was gentler and softer than the vivid Technicolor films of the same period. Thus the set designer were asked for ocher-colored sets and the props and costumes were chosen in subdued colors. Also they changed their film stock to Fuji because it was closer to this look they were cultivating. As long as we are discussing Almendros I think it might be appropriate to end with a quote from his chapter on the film "The Green Room".
"As expected, "The Green Room" was not very well received. The theme of death rarely attracts crowds. This is almost an axiom in the cinema, and by producing so difficult and personal a work, risking almost certain economic failure, Truffaut showed once again that after sixteen films he was still the uncompromising artist he was as a young man." Nestor Almendros, "A Man With A Camera" page 220.


text:
It may not be exactly like a think tank, but you and your equally green-minded friends have generated some excellent ideas for improving a business' energy efficiency. Could this be the beginning of an exciting new eco-business? Keep thinking big. You could be on to something important here!
Surprisingly accurate
maybe :)
am grateful to be able to do this often
i will wait and see how this figures in to my life..
so so true, and a needed reminder
Love apples so I chop three up in the Cuisnart, add cinnamon and nutmeg, chopped walnuts, raisins and some honey with a quarter cup water and cook on high in the microwave for six to nine minutes. Chill in fridge and it is a delicious wholesome snack that really fills you up and keep things moving if you know what I mean. LOL
People always question about being vegetarian for the environment. I just feel like some people are so narrow minded when it comes to things like that.
Now I just need to get the people who live on the NJ beaches, to be more responsible for recycling all their water bottles, beer bottles and overall plastic!


text:
We're back again with a sequel. This one is about what if the Devil granted you the power to astrally project your spirit to commit murders. Pretty cool plot.
About 976-Evil II (1991)
Year: 1991
Starring: George 'Buck' Flower, Rod McCary, Deborah Dutch, Mindy Seeger, Ace Mask, Monique Gabrielle, Philip McKeon, Karen Mayo-Chandler, Brigitte Nielsen, Patrick O'Bryan, Lou Bonacki, Chuck Montalbano, Paul Hertzberg, Ronald Green, Debbie James, René Assa, Leslie Ryan, Paul Coufos, Sigal Diamant, Joy Ballard, Yavone Evans, Eric Anjou, Angela Gordon, Christopher Garr, David Rogge
Director: Jim Wynorski
Reviewer: Florita A.
Score: 2 / 5 starsPublished: April 22, 2009, 6:49 pm
Avg. Rating: 2.1/5 stars from 7 users. Votes: 7.Genre: Horror
How Do You Rate These Movies?
You May Also Like…


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Shakespeare Inn
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TripAdvisor Reviews Shakespeare Inn Telford
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Day 10 - Chirk to Bettisfield - Game Day!!
We got up early & got our jerseys on & Rider flags hung on the boat & photos taken. We stopped into Ellemere to buy some coffee. Sunday so the Tesco closed but we found another shop open to buy coffee & beer. The men got the boat ...
A day in the country, the trip to Sissinghurst
... 400 years old. It had a fireplace dated 1675. Lunch was a cheddar and ale chutney baguette, with some chips - yumm. We also called in to a service stop at Beaconsfield, ( this was before lunch) the poms certainly know how to provide for weary travelers. Sissinghurst is a gorgeous garden established in the 1930's byVita Sackville west ...
Picking Up Pierre
... of our Volvo we didn't notice. On arrival we missed the entrance and luckily we found a 3M factory just down the road with a very large car park, so Phil didn't need to do a 10 point turn! Although on arrival he did a perfect reverse into the pitch. We managed to get the electrics, fridge, cooler and loo working brilliantly and opened a well earned bottle of wine. Tess thought she was ...
Yes, there is a place called Acton Trussell
... Britain is really rather pretty.
Quite late we moored up opposite the Moat House Hotel in the very pretty village of Acton Trussell. We had started to cook when we realised that there was a wedding reception. Well, at least folk drinking champers outside and when the disco lights went on, we moved a 100 metres further south! Sensible, we thought. The hotel is actually a moated farmhouse plus extensions. Very picturskew indeed.
Another pure dead brill curry. And so to ...
A dream country - Iraq
... heart of the Bazaar. Our journey continues as we head north of Dohuk to the Dohku Dam for a traditional Kurdish picnic lunch. After lunch, we head towards the smaller border town of Zakho to see the Delal Bridge, a stunning stone arch bridge over the Khabur River and orient ourselves with a walk through town. Later in the afternoon we return to Dohuk where we have some free time to explore, take tea in one of the many chaikhanas (traditional tea ...


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Dora Apartments
From $56 / night
Description from the owner
Description from the owner
Bedrooms: 2/
Bathrooms: 1/
Sleeps: 5/
Type: Apt. / Condo
In a private 6500m2 olive groove fenced off property ideal for Families & kids
Dora apartments are situated in tragaki, a green area 2km from tsilivi tourist village. Fenced off and surrounded by 6500m2 large olive grove, provide privacy for those wishing to relax in a quiet atmosphere.Big garden privacy and fenced off makes it ideal for kids. Local restaurants, supermarkets, cafes and bars are near-by and the beautiful sandy beach is only 200 meters away. The air-conditioned apartment are spacious and comfortable, fully furnished and equipped. Apartment has two bedrooms (one with double, one with two single beds), one bathroom with shower, a ...Read more
About the owner
About the owner
andreas k.
andreas k.
- Response rate: 65%
- Response time: Within a day
- Calendar updated: today
Overall rating:
Additional Location Information
Getting There
Car is not necessary