text:
The Amsterdam Canal Hotel - Amsterdam
- Free breakfast and free WiFi
Main amenities
- 16 smoke-free guestrooms
- Terrace
- 24-hour front desk
- Daily housekeeping
- Garden
- Front desk safe
- Laundry service
- Multilingual staff
- Concierge services
- Free newspapers in the lobby
- Luggage storage
- Tour/ticket assistance
What's around
- In Canal Ring
- Heineken Experience (0.3 mi / 0.5 km)
- Rembrandt Square (0.5 mi / 0.8 km)
- Skinny Bridge (0.5 mi / 0.8 km)
- Rijksmuseum (0.6 mi / 0.9 km)
- Flower Market (0.7 mi / 1.1 km)
Loved it. Close to everything...walking or riding.
Would be all "5" ratings if the room had a chest of drawers to put clothes away. But...…
Enter dates to check prices
Hotel Info: from Rs12,203
- Standard Room, 1 King Bed, Canal View
- Deluxe Room, 1 King Bed
- Standard Room, 1 King Bed
- Deluxe Room, 1 King Bed, Canal View
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 16 rooms
- This hotel is arranged over 3 floors
- Check-in time 2 PM-midnight
- Check-out time is 11 AM
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- No pets or service animals allowed
- Free WiFi in public areas
- Free WiFi and wired Internet access in rooms
Other information
- Smoke-free property
Nearby Four Star Amsterdam hotels
In the hotel
- Free breakfast
- Bicycle rentals nearby
- 24-hour front desk
- Concierge services
- Tours/ticket assistance
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Luggage storage
- Safe-deposit box at front desk
- Garden
- Terrace
In the room
- Minibar
- Espresso maker
- Coffee/tea maker
- Individually decorated
- Individually furnished
- Private bathroom
- Rainfall showerhead
- Hair dryer
- DVD player
- Desk
- Free newspaper
- Free WiFi
- Phone
- Free bottled water
- Daily housekeeping
- In-room safe
- Connecting/adjoining rooms available
Top Amsterdam hotels
Recently reviewed hotels in Amsterdam
- Corendon Vitality Hotel AmsterdamFrom
- ibis budget Amsterdam AirportFrom
"We were staying for one night prior to taking a flight back to India. The room was clean, and so was the bed and sheets, but it was a little too Spartan. There was no bath mat…"Sep 19, 2015
- Steigenberger Airport Hotel AmsterdamFrom
"Good"Sep 14, 2015
- NH Amsterdam ZuidFrom
"Was very comfortable. Great rooms, very sumptuous breakfast and very helpful staff. The only draw back is the location which is a good 30 minutes by tram from the main attractions."Sep 13, 2015
Nearby hotels
The Amsterdam Canal Hotel - Amsterdam's small print
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
This property does not have elevators.
Special cancellation policies or charges may apply for group reservations (more than 8 rooms for the same hotel / stay dates).
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A 5 percent city/local tax will be charged
Optional extras
Parking is available nearby and costs EUR 38 per 24 hours
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
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with (follower) {
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That's it! Test the movie. Remember, you can increase the
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Georgina has more than fifteen years' experience writing and editing for web, print and voice. With a background in marketing and a passion for words, the time Georgina spent with companies like Sausage Software and sitepoint.com cemented her lasting interest in the media, persuasion, and communications culture.

subset: commoncrawl


text:
Tribe says that Obama was one of his brightest students. Why is Obama then refusing to release his student records from Occidental College, Columbia, and Harvard Law?
So, what, you'd vote for him if he was order of the coif? EIC of the harvard law review doesn't do it for you, but a certain gpa would? Let's face it pal. You're a hypocrite.
Can you believe it? A Clarence Thomas is on the court and A Larry Tribe is not. What a country. Truck was a student of Tribe and I can tell you this - the difference between Tribe and Thomas intellectually is like the difference between ice cream and battleships, Tribe the obvious superior.
misspoke? where is an apology, he always apologizes to someone, typically outside US
why did mr. Tribe quit working for the government?
"unprecedented in the last 80 years on this issue" is a far cry from "unprecedented" writ large...I'm sure it was a simple, honest mistake
I'm a sweet, friendly, honest , caring girl in search of "the one".I've been single for over one years so i got a name Amanda2011 on----- richmatchmaking.c%o~m -------to find my Mr right..it is the first and best club for wealthy people and their admirers. …you don't have to be rich ,but you can meet one there , maybe you wanna check it out or tell your friends! Sometimes the perfect person for you is the one you least expect. maybe you can have a try.asderttyuyui...................
Tribe failed to mention FDR end up packing the court to his liking by bribing justices to retire with newly implemented pensions.
Nothing the White House says or does is accidental. Obama's comments are an attempt to begin to de-legitimize the Supreme Court in anticipation of the possibility the government might lose its case. The contradiction of his defense of the health care law but his non defense of DOMA, which passed with more votes than the health care bill, shows how this president steers by the rudder of his personal agenda and not the constitution he swore to uphold.
At Harvard it seems they--teachers & students alike-- do not know about federalism. Lochner did not involve a congressional act. Scotus held a NY State law unconstitutional as a violation of an individual freedom of contract under the US constitution. It had nothing to do with Congress or the Commerce Clause.
Whether obama was one of the best and brightest at Harvard or not, he should come clean on his school records and other aspects of his rather murky past. Occam's razor would say that the simplest explanation is that he doesn't want something in those various records to be public. And further, whatever it is would probably not enhance his standing in the eyes of the public..
Politicians in trouble are funny to me. First, they try to explain it away or ignore it, which makes people even more angry. Then their apologists work overtime trying to make some explanation and whichever one is found to be least offensive or best poll-tested is all of a sudden the new explanation that everyone starts believing.
HLS is well known for its unrigorouos easy grading curve that is the mark of a diploma mill.
Of course his clarified comment is also wrong, in that it ignores the two most significant commerce clause cases of the last two decades: Lopez and Morrison
..why many parties, typically supporting BO, Pelosi etc, received waiver to comply with healthcare law if it is good for everyone? ..isn't a constitutional problem, if common law can be ignored by some?
CLS is well known for its unrigorouos easy approach to spelling that is the mark of a junior high school.
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Unless the witness is a puppeteer and wrote the script in controversy, he is incompetent to say what another person meant or opine about another's mis-speaking.
Of course he misspoke-he has been misspeaking now since January 2009. Of course, it's not as if he is World's Greatest Orator or-ahh never mind.
"Misspoke"-democrat speak for lying.
The contradiction of his defense of the health care law but his non defense of DOMA, which passed with more votes than the health care bill, shows how this president steers by the rudder of his personal agenda and not the constitution he swore to uphold. http://www.birthdaygiftideasformen.org/
The Law Blog covers the legal arena's hot cases, emerging trends and big personalities. It's brought to you by lead writer Jacob Gershman with contributions from across The Wall Street Journal's staff. Jacob comes here after more than half a decade covering the bare-knuckle politics of New York State. His inside-the-room reporting left him steeped in legal and regulatory issues that continue to grab headlines.
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A Florida judge is poised to unveil his plan for reshaping the state's congressional boundaries, the latest chapter in a contentious and increasingly messy effort to strip away partisan politics from redistricting.
In trials in New York state court, unlike in most other states, jurors have to deliberate without written instructions. It's a rule that seems to be affecting the deliberations—which entered a 12th day Friday—in the financial fraud case against three former Dewey & LeBoeuf executives.
A federal judge spanked the state of Kentucky for trying to censor a prominent parenting columnist in a First Amendment ruling handed down this week.
The number of attorneys in Texas grew by nearly 20,000 over the last decade, outpacing growth in the state's general population, according to a report by the State Bar of Texas.
Content engaging our readers now, with additional prominence accorded if the story is rapidly gaining attention. Our WSJ algorithm comprises 30% page views, 20% Facebook, 20% Twitter, 20% email shares and 10% comments.


text:
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"She is deeply, deeply passionate about the arts and this art form — music — in particular," Jacobs continued. "And she spends all her waking hours in pursuit of the ideal that music and art can better her community and our world. In this age of corporate concert producers, you don't see that often and you don't see someone with impact and the level of effectiveness she has."
"Makeda 'Dread' Cheatom turned an old water tower into a major reggae venue drawing larger audiences in San Diego, California."
"Dirigido por Makeda "Dread" Cheatom, el Culture Beat Performing Arts Center comenzó a funcionar en Ensenada en marzo del 2010"
"from pioneering California's longest running reggae radio show (airing Sundays from 8 to 10 p.m. on 91X) to spreading the WorldBeat word of positivity and unity, Ms. Cheatom has been a very busy do-gooder."
""I really believe it's a whole different day coming." — Makeda "Dread" Cheatom"


text:
Household Durables
Company Overview of M & R Ironworks, LLC
Company Overview
M & R Ironworks, LLC manufactures and markets custom iron railings, gates, and enclosures. The company was incorporated in 2005 and is based in Winter Park, Florida.
7260 Gardner Street
Winter Park, FL 32792
United States
Founded in 2005
Key Executives for M & R Ironworks, LLC
M & R Ironworks, LLC does not have any Key Executives recorded.
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"This is the End,
...Beautiful friend The End.
This is the End,
...My only friend The End."
Today's Paper, also known as the e-Edition, is an online replica of the printed newspaper. You can view today's paper or previous issues.
The Journal Sentinel sports staff brings Milwaukee Bucks fans the latest news, notes and analysis
Las Vegas - San Antonio dominated in the paint on the way to a 90-80 victory over the Bucks in NBA Summer League play on Friday at Cox Pavilion. »Read Full Blog Post
Read and share your thoughts on this story.


text:
Spoiler whore's thread! (enter at your own risk)
View Single Post
September 21 2005, 04:18 AM
Dorian Thompson
Location: Oklahoma City, Oklahoma
Re: Spoiler whore's thread! (enter at your own ris
Oh man, that is going to be some terrific angst when Adama is contemplating trading the cylon for his son. I'm loving those spoilers. Bill will be on edge; Tigh will be on edge because of Ellen.
Campbell's pilot may have gotten a pick up as a mid season replacement. Moore did say there would be another significant death. Maybe poor Billy will bite it. It would be cool if they revealed him as a sleeper cylon before it all goes down.
Best disaster animal relief charity around. Don't forget our animal friends. Donate, train to be a volunteer, or be a foster parent for a displaced pet.
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With 1.7 million freelancers, we'll match you with the perfect talent.
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The Hit Man imports bamboo blocks and turns them into baseball bats in Canada. We sell a variety of baseball bats that include different lengths and weights. These bats are used by all ages.
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text:
No photo. Brown butterfly with prominent eye-spots on its fore-wings and hind-wings. Shape and markings consistent with Lethe complex and not Enodia. Post-median line on hind-wing gently curved and not at all jagged as in Lethe eurydice. Flying in wet woods with abundant sedge growing on hummocks.
early am at sunrise, in road with rodent in talons. hopped off the road to safety.
at otter creek
We heard the song to supplement our ID.


text:
Dear HALO Supporters,
It is hard to imagine having to worry that your next step might set off an explosion. Can you imagine a child, unable to remember a war, yet becoming its victim?
Loeng Vouch (nine years old) and Loeng Om (seven years old) do not attend school because its far away and their family cannot afford to send them. Instead they help cut grass and bamboo that the family can sell. Their mother, Mrs. Sngoun Oun supports the family of five. Mrs. Oun was alarmed to learn that HALO found a landmine behind their home where her children often walk. The family had recently moved to Malai District from Kampot Provnice to work the land that belongs to her sister. They had no idea the land was mined. Mrs. Oun was afraid to grow crops in the dangerous field but she couldn't go back to Kampot, as she couldn't find work. She was scared for her children.
HALO, thanks to supporters like you, removed the mines from their land this May. Now Mrs. Oun and her sister have plans to farm. If they make enough money selling their crops the children might be able to attend school. For now, it is enough to know that they are safe.
Thank you for helping to protect the children of Cambodia. Together we are making landmines history, not some innocent person's future.
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
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United States
Program Officer
San Francisco,
United States


text:
Rickey R. Hass was named Acting Inspector General for the U.S. Department of Energy effective October 4, 2105. As the Acting Inspector General, he is responsible for a nationwide, independent program of audits, inspections, and law enforcement efforts related to the Department of Energy's programs and operations.
Virginia Grebasch was appointed Counsel to the Inspector General in August, 2012. She provides comprehensive legal advice to the Inspector General and senior leadership, and serves as the primary liaison to Congressional staff.
John R. Hartman became the Deputy Inspector General for Investigation in December 2010. Prior to this he was the Assistant Inspector General for Investigations. Mr. Hartman is responsible for all investigations of the Department's programs and operations, which includes over 70 facilities and 100,000+ Federal and contractor employees. He directs a Federal workforce of Special Agents located across the country.
John Dupuy was appointed as the Assistant Inspector General for Investigations in June 2015. Mr. Dupuy is responsible for investigations of the Department's programs and operations. Mr. Dupuy has been part of the Office of Inspector General (OIG) community since 1991, and has served in a variety of leadership positions throughout his career in both, the field and Headquarters. Mr. Dupuy comes to us from the Department of Homeland Security (DHS) OIG, with prior experience at the Department of the Interior and Department of Housing and Urban Development's OIG.
Daniel M. Weeber was appointed Assistant Inspector General for Audits and Administration in July 2012. He directs the planning, execution and reporting of all audits for the Eastern Audits Division, which include the annual financial statement audit, information technology audits, special reviews, and performance reviews of the Department's major programs. Mr.
April G. Stephenson was appointed Assistant Inspector General for Inspections in June 2015. She directs the planning, execution, and reporting on all inspections of the Department's programs and operations. Ms. Stephenson was previously the Assistant Inspector General for Audits. Prior to her positions in the Office of Inspector General, Ms. Stephenson was the Chief Operating Officer of the Department of Energy's Loan Programs Office. Ms.
Tara A. Porter was appointed the Assistant Inspector General for Management and Administration in March 2014. She originally joined the Office of Inspector General in August 2010 as manager within the Office of Investigations.
Office of Inspector General
1000 Independence Avenue, SW
Washington, DC 20585202-586-4128


text:
Predictions are in on these UK flag fliers at ADE
Only Calvin knows if *those* allegations are true, but the bigger questions is, why does anyone care?
We chat to the South African Live House Music duo ahead of two massive shows at ADE and Electric Brixton.
As our ultimate comedown album lands to soothe your tired ears, we salute the DJs who share your Sunday morning pain.
Meet Priests of Beat - the world's first (we assume) 'catholic EDM' group.
As the wheel of ADE starts turning, Amsterdam resident Patrice Baumel spins together a list of Amsterdam top spots.
Neelix is in the mix ahead of his much anticipated return to The Gallery on Friday 16th October.
Everything that happened in electronic music this weekend, featuring Bugged Out, TomorrowWorld and a real life Blood Rave.
The video exudes all the sass you need to channel this weekend.
The group celebrate their twentieth birthday by hinting that it may not be the end for Faithless.
We got a sneaky peak behind the scenes at KDA's new video with Katy B and Tinie Tempah.
Paul Oakenfold talks Perfecto, blasts the BRITS and announces his plan to save London's nightclubs.
We bring you our brand new mix series, SoundOf.
Seth will be cooking up a three course lunch for Amsterdam's homeless population.
Even DJs need to prove their lives are beautiful.
Meet your new favourite DJ: a three-year-old from South Africa.
DJ Snoopadelic AKA Snoop Dogg made his Boiler Room debut at the Ray Ban Roller Disco.
The trip hop originators announce a European tour.
Tom Staar And Kryder Want To Teach You How To DJ.
The 73 year old DJ has been missing since July
Ministry of Sound's very own Tropical House hero is back after beating Bieber to the top spot.
Paul Oakenfold is in the mix to celebrate 25 years of his groundbreaking label, Perfecto Records.
Take a trip through the clouds with the video premiere of "Sweet Surrender" the new song from Shermanology.
Everything that happened in electronic music this weekend, featuring Jack Ü, Sam Smith, Disclosure, and... the Conservative Party.


text:
Town Square
Tonight: Compensation cuts, city manager's housing, on Atherton council agenda
Original post made on Jan 16, 2013
Read the full story here Web Link posted Tuesday, January 15, 2013, 10:23 AM
Comments (3)
a resident of another community
on Jan 16, 2013 at 2:56 pm
Municipal employees in other Bay Area cities have had to pay their share of the pension equation for years, so it would seem fair for Atherton's employees to do the same.
As to subsidizing the housing costs of a non-resident City Manager, if the City Charter provides for that, it should be revised to eliminate that cost. If it is simply a term of his contract, the contract needs to be revised--no way does it cost $2500/month to commute that distance. Also, wouldn't a City Manager who was required to live in the city s/he serves be able to represent its residents more realistically? If residency were a requirement, the City Manager would be able to respond immediately and be on site when situations requiring his/her attention arose.
a resident of Menlo Park: Downtown
on Jan 16, 2013 at 4:04 pm
SteveC is a registered user.
I don't believe that a city or town require employees to live where they work.
a resident of another community
on Jan 16, 2013 at 4:05 pm
I say let this guy live where he wants. But in the article, he says he should get paid more for not living in Atherton, so he's not 24x7. Isn't it the other way around?
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Mademoiselle Colette, now open in downtown Menlo Park
By Elena Kadvany | 9 comments | 2,144 views
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How early is too early to make or buy a Halloween costume
By Cheryl Bac | 9 comments | 394 views
The Big Four - Part one
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Can Menlo Park afford to take away El Camino lanes from parking or vehicle movement?
By Stuart Soffer | 3 comments | 317 views


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BRAZIL: JBS profit rises as sales jump
Brazilian beef group JBS has booked an increase in third-quarter profits as sales rose by almost one-quarter in the period.
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text:
Internet over power lines may jam airwaves, but remedies exist
Can only you hear me now?
Public Technology Inc.
Ole Virginia Hams
American Radio Relay League
Amateur radio operators are wary about a new technology that can carry high-speed Internet service via power lines. They say it causes significant interference with their communications and could potentially interrupt public safety operations.
The technology's supporters acknowledge that broadband over power lines (BPL) sometimes creates interference. But they say technology exists to remedy the problem.
BPL bundles radio frequency with electrical currents either through aboveground wires or underground pipes. Because electric currents and radio waves operate at different frequencies, they don't interfere with one another. Customers need to connect only a modem to their outlets to receive the signal.
Manassas, Va., recently installed BPL technology throughout the city, and several hundred residents have signed up for the broadband service. The city's public works department did the installation. Communication Technologies, based in Chantilly, Va., will own and operate the network and provide Internet service.
George Tarnovsky, an amateur radio operator who lives near Manassas, doesn't discount BPL's benefits, but he said it interferes with ham radio signals.
Tarnovsky also said ham radio transmissions could create a dangerous situation if they interfere with BPL transmissions.
"What if you interrupt a BPL transmission, and they're doing voice over IP, and it happens to be an emergency call?" he asked. "This could possibly be a life and death situation. Who's going to be liable for this should something tragic happen?"
Tarnovsky and several ham radio colleagues filed a complaint with the Federal Communications Commission, which asks the two sides to work it out.
Walter Adams, a Communication Technologies vice president, said radio operators have pointed out several instances in which the technology exceeded FCC specifications and caused interference. To remedy those problems, dynamic notching devices were put in place.
"You just block certain portions of the frequency…that is typically in an area where the ham radio people operate," Adams said.
In Manassas, he said the technology shouldn't interfere with the public safety communications equipment, which operates in the 900 MHz range. BPL technology operates in unlicensed spectrum between the 4 MHz and 23 MHz frequencies.
Adams said several federal agencies have expressed concern about possible interference with some satellite-to-ground communications, primarily along the West Coast. The FCC established additional regulations for some geographic areas to address those concerns, he said. He said another group has concerns about possible BPL interference with aeronautical navigational radio.
Adams said amateur radio operators, who are trying to limit interference with their operations, are behind most of the complaints. But he thinks both sides can operate simultaneously.
Alan Shark, executive director of Public Technology, a technology organization that works with several cities and counties, said he is a fan of ham radio operators. But their complaints that BPL technology causes significant interference are misguided, he said.
"This has become almost a religious mantra with the ham operators," said Shark, who has previously led several telecommunications associations, including the Power Line Communications Association.
Shark said interference comes from many sources, and Manassas' BPL deployment minimizes interference because of technology developed by Israel-based Main.net Communications. He added that the FCC and the National Telecommunications and Information Administration have done testing and devised rules and regulations for addressing the interference.
Adams said the FCC offers a prescriptive mandate that states that BPL technology should not harmfully interfere with ham radios.
"It's not a question of whether BPL interferes with ham radios. It does," he said. "But then again so does your garage door opener, so does your diesel engine or your car. It's a question of how harmful it is
in terms of how loud it is and how much
interference" it causes.
Manassas, Va., with a population of 37,000, has installed
broadband-over-power-lines technology across its electrical infrastructure. That infrastructure consists mostly of underground fiber-optic cables. Here are some facts about the Internet service that the new infrastructure supports.
-- Dibya Sarkar
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The General Services Administration's Enterprise Infrastructure Solutions contract will anchor the agency's NS 2020 telecommunications strategy.
House and Senate both approve a measure to maintain funding at fiscal 2015 levels through Dec. 11.
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Agency heads, acquisition officers and even CIOs don't need to be hard-core techies. FCW's four-part look at the expertise that's really required to make federal IT run.
FCW recognizes 14 individuals having an outsized impact early in their careers.
As Steve Kelman returns from a summer of aggressive medical treatment, he considers the all-too-common aversion to short-term sacrifices.
Massive open online courses can offer specialized IT instruction on a flexible schedule and on the cheap. That may not always mesh with government's preference for structure and certification, however.
The federal government craves more cybersecurity professionals. These six schools are helping meet that demand.
Former ACT president will take a job with Gartner, follow his spouse to Vienna, Austria.
8609 Westwood Center Drive, Suite 500Vienna, VA 22182-2215 703-876-5100
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Free delivery when you spend over £75 (GBP).
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Knitted jumpers - Black
You must select a size
Knitted jumper by TIGER OF SWEDEN JEANS. Rounded neckline. Rib knit cuffs and hem. Logo patch at front hem. Hand wash recommended.
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text:
Recent Research Articles from UNTHSC
Prognostic value of pre-therapy platelet elevation in oropharyngeal cancer patients treated with chemoradiation.
Prognostic value of pre-therapy platelet elevation in oropharyngeal cancer patients treated with chemoradiation.
Int J Cancer. 2015 Sep 28;
Authors: Shoultz-Henley S, Garden AS, Mohamed AS, Sheu T, Kroll MH, Rosenthal DI, Brandon Gunn G, Hayes AJ, French C, Eichelberger H, Kalpathy-Cramer J, Smith BD, Phan J, Ayoub Z, Lai SY, Pham B, Kies M, Gold KA, Sturgis E, Fuller CD
The purpose of this study is to evaluate potential associations between increased platelets and oncologic outcomes in oropharyngeal cancer patients receiving concurrent chemoradiation. 433 oropharyngeal cancer patients (OPC) treated with intensity modulated radiation therapy (IMRT) with concurrent chemotherapy between 2002 and 2012 were included under an approved IRB protocol. Complete blood count (CBC) data was extracted. Platelet and hemoglobin from the last phlebotomy (PLTpre-chemoRT, Hgbpre-chemoRT ) before start of treatment were identified. Patients were risk-stratified using Dahlstrom-Sturgis criteria and were tested for association with survival and disease-control outcomes. Locoregional control (LRC), freedom from distant metastasis (FDM) and overall survival (OS) were decreased (p<0.03, p<0.04, and p<0.0001, respectively) for patients with PLT pre-chemoRT value of ≥350 x 10(9) /L. Actuarial 5-year locoregional control (LRC) and FDM were 83% and 85% for non-thrombcythemic patients while patient with high platelets had 5-year LRC and FDM of 73% and 74%, respectively. Likewise, 5- year OS were better for patients with normal platelet counts by comparison (76% vs. 57%; p<0.0001). Comparison of univariate parametric models demonstrated PLTpre-chemoRT was better among tested models. Multivariate assessment demonstrated improved performance of models which included pre-therapy platelet indices. On Bayesian information criteria analysis, the optimal prognostic model was then used to develop nomograms predicting 3-, 5-, and 10-year OS. In conclusion, pre-treatment platelet elevation is a promising predictor of prognosis, and further work should be done to elucidate the utility of anti-platelets in modifying risk in OPC patients. This article is protected by copyright. All rights reserved.
PMID: 26414107 [PubMed - as supplied by publisher]
Impaired sodium-evoked PVN neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Galphai2 proteins.
Impaired sodium-evoked PVN neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Galphai2 proteins.
Acta Physiol (Oxf). 2015 Sep 27;
Authors: Carmichael CY, Carmichael AC, Kuwabara JT, Cunningham JT, Wainford RD
AIM: We determined the role of brain Gαi2 proteins in mediating the neural and humoral responses of conscious male Sprague-Dawley rats to acute peripheral sodium challenge.
METHODS: Rats pretreated (24-hours) intracerebroventricularly with targeted oligodeoxynucleotide (25 μg 5μl(-1) ) to downregulate brain Gαi2 protein expression or a scrambled control oligodeoxynucleotide were challenged with an acute sodium load (intravenous bolus 3M NaCl; 0.14 ml 100g(-1) ) and cardiovascular parameters were monitored for 120-minutes. In additional groups, hypothalamic paraventricular nucleus Fos immunoreactivity was examined at baseline, 40-minutes, and 100-minutes post-sodium challenge.
RESULTS: In response to intravenous hypertonic saline, no difference was observed in peak change in mean arterial pressure between groups. In scrambled oligodeoxynucleotide pretreated rats, arterial pressure returned to baseline by 100-minutes while it remained elevated in Gαi2 oligodeoxynucleotide pretreated rats (P<0.05). No difference between groups was observed in sodium-evoked increases in Fos-positive magnocellular neurons or vasopressin release. V1a receptor antagonism failed to block the prolonged elevation of arterial pressure in Gαi2 oligodeoxynucleotide pretreated rats. A significantly greater number of Fos-positive ventrolateral parvocellular, lateral parvocellular, and medial parvocellular neurons were observed in scrambled vs. Gαi2 oligodeoxynucleotide pretreated rats at 40- and 100-minutes post-hypertonic saline challenge (P<0.05). In scrambled, but not Gαi2 oligodeoxynucleotide pretreated rats, hypertonic saline evoked suppression of plasma norepinephrine (P<0.05).
CONCLUSION: This highlights Gαi2 protein signal transduction as a novel central mechanism acting to differentially influence paraventricular nucleus parvocellular neuronal activation, sympathetic outflow, and arterial pressure in response to acute hypertonic saline, independently of actions on magnocellular neurons and vasopressin release. This article is protected by copyright. All rights reserved.
PMID: 26412230 [PubMed - as supplied by publisher]
Comorbid Depression and Diabetes as a Risk for Mild Cognitive Impairment and Alzheimer's Disease in Elderly Mexican Americans.
Comorbid Depression and Diabetes as a Risk for Mild Cognitive Impairment and Alzheimer's Disease in Elderly Mexican Americans.
J Alzheimers Dis. 2015 Jul 9;47(1):129-136
Authors: Johnson LA, Gamboa A, Vintimilla R, Cheatwood AJ, Grant A, Trivedi A, Edwards M, Hall JR, O'Bryant SE
BACKGROUND: The links between diabetes, depression, and Alzheimer's disease (AD) has been established, but they are still poorly understood. However, little research has examined the effect that comorbidity of depression and diabetes has on cognitive impairment in an ethnically diverse sample.
OBJECTIVE: The purpose of this study was to investigate the relationship between comorbid diabetes and depression on cognitive dysfunction; and examine the relationship in an ethnically diverse population.
METHODS AND RESULTS: Analyses of data from 2,436 participants (914 men and 1,522 women) of three separate cohorts: HABLE, FRONTIER, and TARCC. In the HABLE cohort, comorbidity (odds ratio [OR] = 3.008; 95% CI = 1.358-6.667), age (OR = 1.138; 95% CI = 1.093-1.185), and education (OR = 0.915; 95% CI = 0.852-0.982) increased the risk of mild cognitive impairment (MCI) diagnosis among elderly Mexican American. In the TARCC cohort, results showed an increase risk of MCI in both non-Hispanic whites (OR = 18.795; 95% CI = 2.229-158.485) and Mexican Americans (OR = 8.417; 95% CI = 2.967-23.878). Finally, results in the FRONTIER cohort showed that in elderly Mexican Americans, comorbidity (OR = 2.754; 95% CI = 1.084-6.995) and age (OR = 1.069; 95% CI = 1.023-1.118) significantly increased risk of MCI. In non-Hispanic whites, comorbidity did not significantly increase risk of MCI.
CONCLUSIONS: Among elderly Mexican Americans, comorbid depression and diabetes significantly increased risk for MCI and AD across cohorts. Effects of comorbid diabetes and depression on MCI were inconclusive. Our results support the link between comorbid diabetes and depression and risk for cognitive decline among Mexican Americans. This finding is of critical importance as the Hispanic population is at higher risk of developing AD.
PMID: 26402761 [PubMed - as supplied by publisher]
Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer.
Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer.
J Inorg Biochem. 2015 Sep 14;153:23-31
Authors: Munaweera I, Shi Y, Koneru B, Patel A, Dang MH, Di Pasqua AJ, Balkus KJ
Nitric oxide (NO) and cisplatin releasing wrinkle-structured amine-modified mesoporous silica (AMS) nanoparticles have been developed for the treatment of non-small cell lung cancer (NSCLC). The AMS and NO- and cisplatin-loaded AMS materials were characterized using TEM, BET surface area, FTIR and ICP-MS, and tested in cell culture. The results show that for NSCLC cell lines (i.e., H596 and A549), the toxicity of NO- and cisplatin-loaded silica nanoparticles (NO-Si-DETA-cisplatin-AMS) is significantly higher than that of silica nanoparticles loaded with only cisplatin (Si-DETA-cisplatin-AMS). In contrast, the toxicity of NO-Si-DETA-cisplatin-AMS toward normal lung cell lines is not significantly different from that of Si-DETA-cisplatin-AMS (normal lung fibroblast cells WI-38) or is even lower than that of Si-DETA-cisplatin-AMS (normal lung epithelial cells BEAS-2B). The NO-induced sensitization of tumor cell death demonstrates that NO is a promising enhancer of platinum-based lung cancer therapy.
PMID: 26402659 [PubMed - as supplied by publisher]
Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline.
Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline.
J Alzheimers Dis. 2015 Aug 6;
Authors: Lista S, Molinuevo JL, Cavedo E, Rami L, Amouyel P, Teipel SJ, Garaci F, Toschi N, Habert MO, Blennow K, Zetterberg H, O'Bryant SE, Johnson L, Galluzzi S, Bokde AL, Herholz K, Bakardjian H, Dubois B, Jessen F, Carrillo MC, Aisen PS, Hampel H
There is evolving evidence that individuals categorized with subjective cognitive decline (SCD) are potentially at higher risk for developing objective and progressive cognitive impairment compared to cognitively healthy individuals without apparent subjective complaints. Interestingly, SCD, during advancing preclinical Alzheimer's disease (AD), may denote very early, subtle cognitive decline that cannot be identified using established standardized tests of cognitive performance. The substantial heterogeneity of existing SCD-related research data has led the Subjective Cognitive Decline Initiative (SCD-I) to accomplish an international consensus on the definition of a conceptual research framework on SCD in preclinical AD. In the area of biological markers, the cerebrospinal fluid signature of AD has been reported to be more prevalent in subjects with SCD compared to healthy controls; moreover, there is a pronounced atrophy, as demonstrated by magnetic resonance imaging, and an increased hypometabolism, as revealed by positron emission tomography, in characteristic brain regions affected by AD. In addition, SCD individuals carrying an apolipoprotein ɛ4 allele are more likely to display AD-phenotypic alterations. The urgent requirement to detect and diagnose AD as early as possible has led to the critical examination of the diagnostic power of biological markers, neurophysiology, and neuroimaging methods for AD-related risk and clinical progression in individuals defined with SCD. Observational studies on the predictive value of SCD for developing AD may potentially be of practical value, and an evidence-based, validated, qualified, and fully operationalized concept may inform clinical diagnostic practice and guide earlier designs in future therapy trials.
PMID: 26402088 [PubMed - as supplied by publisher]
Biomarkers in Sporadic and Familial Alzheimer's Disease.
Biomarkers in Sporadic and Familial Alzheimer's Disease.
J Alzheimers Dis. 2015 Jul 24;47(2):291-317
Authors: Lista S, O'Bryant SE, Blennow K, Dubois B, Hugon J, Zetterberg H, Hampel H
Most forms of Alzheimer's disease (AD) are sporadic (sAD) or inherited in a non-Mendelian fashion, and less than 1% of cases are autosomal-dominant. Forms of sAD do not exhibit familial aggregation and are characterized by complex genetic and environmental interactions. Recently, the expansion of genomic methodologies, in association with substantially larger combined cohorts, has resulted in various genome-wide association studies that have identified several novel genetic associations of AD. Currently, the most effective methods for establishing the diagnosis of AD are defined by multi-modal pathways, starting with clinical and neuropsychological assessment, cerebrospinal fluid (CSF) analysis, and brain-imaging procedures, all of which have significant cost- and access-to-care barriers. Consequently, research efforts have focused on the development and validation of non-invasive and generalizable blood-based biomarkers. Among the modalities conceptualized by the systems biology paradigm and utilized in the "exploratory biomarker discovery arena", proteome analysis has received the most attention. However, metabolomics, lipidomics, transcriptomics, and epigenomics have recently become key modalities in the search for AD biomarkers. Interestingly, biomarker changes for familial AD (fAD), in many but not all cases, seem similar to those for sAD. The integration of neurogenetics with systems biology/physiology-based strategies and high-throughput technologies for molecular profiling is expected to help identify the causes, mechanisms, and biomarkers associated with the various forms of AD. Moreover, in order to hypothesize the dynamic trajectories of biomarkers through disease stages and elucidate the mechanisms of biomarker alterations, updated and more sophisticated theoretical models have been proposed for both sAD and fAD.
PMID: 26401553 [PubMed - as supplied by publisher]
Endothelin-Mediated Changes in Gene Expression in Isolated Purified Rat Retinal Ganglion Cells.
Endothelin-Mediated Changes in Gene Expression in Isolated Purified Rat Retinal Ganglion Cells.
Invest Ophthalmol Vis Sci. 2015 Sep 1;56(10):6144-6161
Authors: He S, Park YH, Yorio T, Krishnamoorthy RR
Purpose: A growing body of evidence suggests that the vasoactive peptides endothelins (ETs) and their receptors (primarily the ETB receptor) are contributors to neurodegeneration in glaucoma. However, actions of ETs in retinal ganglion cells (RGCs) are not fully understood. The purpose of this study was to determine the effects of ETs on gene expression in primary RGCs.
Methods: Primary RGCs isolated from rat pups were treated with 100 nM of ET-1, ET-2, or ET-3 for 24 hours. Total RNA was extracted followed by cDNA synthesis. Changes in gene expression in RGCs were detected using Affymetrix Rat Genome 230 2.0 microarray and categorized by DAVID analysis. Real-time PCR was used to validate gene expression, and immunocytochemistry and immunoblotting to confirm the protein expression of regulated genes.
Results: There was more than 2-fold upregulation of 328, 378, or 372 genes, and downregulation of 48, 33, or 28 genes with ET-1, ET-2, or ET-3 treatment, respectively, compared to untreated controls. The Bcl-2 family, S100 family, matrix metalloproteinases, c-Jun, and ET receptors were the major genes or proteins that were regulated by endothelin treatment. Immunocytochemical staining revealed a significant increase in ETA receptor, ETB receptor, growth associated protein 43 (GAP-43), phosphorylated c-Jun, c-Jun, and Bax with ET-1 treatment. Protein levels of GAP-43 and c-Jun were confirmed by immunoblotting.
Conclusions: Expression of key proteins having regulatory roles in apoptosis, calcium homeostasis, cell signaling, and matrix remodeling were altered by treatment with endothelins. The elucidation of molecular mechanisms underlying endothelins' actions in RGCs will help understand endothelin-mediated neurodegenerative changes during ocular hypertension.
PMID: 26397462 [PubMed - as supplied by publisher]
Spinal Stabilization Exercise Effectiveness for Low Back Pain in Adolescent Idiopathic Scoliosis: A Randomized Trial.
Spinal Stabilization Exercise Effectiveness for Low Back Pain in Adolescent Idiopathic Scoliosis: A Randomized Trial.
Pediatr Phys Ther. 2015 Winter;27(4):396-402
Authors: Zapata KA, Wang-Price SS, Sucato DJ, Thompson M, Trudelle-Jackson E, Lovelace-Chandler V
PURPOSE: To compare 8 weeks of weekly supervised spinal stabilization exercises with 1-time treatment in participants with low back pain and adolescent idiopathic scoliosis.
METHODS: Participants were randomly assigned to the supervised or unsupervised group. Seventeen participants in the supervised group received weekly physical therapy, and 17 participants in the unsupervised group received a 1-time treatment followed by home exercises.
RESULTS: Significant between-group differences were found in the Numeric Pain Rating Scale and the Patient-Specific Functional Scale scores after 8 weeks (P < .01), indicating the supervised group had significantly more pain reduction and functional improvements than the unsupervised group. However, no between-group differences were found in back muscle endurance, the revised Oswestry Back Pain Disability Questionnaire scores, or the Global Rating of Change scores.
CONCLUSIONS: Supervised physical therapy may be more effective than 1-time treatment in reducing pain and improving function in patients with adolescent idiopathic scoliosis and low back pain.
VIDEO ABSTRACT: For more insights from the authors, access Supplemental Digital Content 1, at http://links.lww.com/PPT/A85.
PMID: 26397085 [PubMed - as supplied by publisher]
Inhibition of hypoxia inducible factor-1α downregulates the expression of epithelial to mesenchymal transition early marker proteins without undermining cell survival in hypoxic lens epithelial cells.
Inhibition of hypoxia inducible factor-1α downregulates the expression of epithelial to mesenchymal transition early marker proteins without undermining cell survival in hypoxic lens epithelial cells.
Mol Vis. 2015;21:1024-1035
Authors: Cammarata PR, Neelam S, Brooks MM
PURPOSE: The purpose of this study was to identify potential therapeutic strategies to slow down or prevent the expression of early-onset epithelial to mesenchymal transition (EMT) marker proteins (fibronectin and alpha smooth muscle actin, α-SMA) without sacrificing the synthesis and accumulation of the prosurvival protein vascular endothelial growth factor (VEGF) in cultured virally transformed human lens epithelial (HLE) cells.
METHODS: HLE-B3 cells, maintained in a continuous hypoxic environment (1% oxygen), were treated with SB216763, a specific inhibitor of glycogen synthase kinase-3β (GSK-3β) catalytic activity. Western blot analysis was employed to detect the cytoplasmic and nuclear levels of β-catenin, as well as the total lysate content of fibronectin and α-SMA. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of VEGF in cell culture medium. A hypoxia-inducible factor-1α (HIF-1α) translation inhibitor and an HIF-2α translation inhibitor were independently employed to evaluate the effect of hypoxia inducible factor inhibition on EMT marker protein and VEGF expression. XAV932 was used to assess the suppression of nuclear β-catenin and its downstream effect on EMT marker proteins and VEGF expression.
RESULTS: SB216763-treated HLE-B3 cells caused marked inhibition of GSK-3β activity prompting a significant increase in the translocation of cytoplasmic β-catenin to the nucleus. The enhancement of nuclear β-catenin looked as if it positively correlated with a significant increase in the basal expression of VEGF as well as increased expression of fibronectin and α-SMA. In conjunction with SB216763, coadministration of an HIF-1α translation inhibitor, but not an HIF-2α translation inhibitor, markedly suppressed the expression of fibronectin and α-SMA without affecting VEGF levels. Treatment with XAV932 significantly reduced the level of nuclear β-catenin, but the levels of neither the EMT marker proteins nor VEGF were changed.
CONCLUSIONS: Recently, we reported that nuclear β-catenin, but not HIF-2α, regulates the expression of fibronectin and α-SMA in atmospheric oxygen. In marked contrast, data from the hypoxic condition clearly establish that nuclear β-catenin plays little apparent role in the expression of EMT marker proteins. Instead, the loss of HIF-1α (but not HIF-2α) decreases the expression of the EMT marker proteins without sacrificing the levels of the prosurvival protein VEGF. These findings support the development of a potentially relevant therapeutic strategy to undermine the progression of normal cells to the mesenchymal phenotype in the naturally hypoxic lens without subverting cell viability.
PMID: 26392741 [PubMed - as supplied by publisher]
Novel Y-chromosome Short Tandem Repeat Variants Detected Through the Use of Massively Parallel Sequencing.
Novel Y-chromosome Short Tandem Repeat Variants Detected Through the Use of Massively Parallel Sequencing.
Genomics Proteomics Bioinformatics. 2015 Sep 18;
Authors: Warshauer DH, Churchill JD, Novroski N, King JL, Budowle B
Massively parallel sequencing (MPS) technology is capable of determining the sizes of short tandem repeat (STR) alleles as well as their individual nucleotide sequences. Thus, single nucleotide polymorphisms (SNPs) within the repeat regions of STRs and variations in the pattern of repeat units in a given repeat motif can be used to differentiate alleles of the same length. In this study, MPS was used to sequence 28 forensically-relevant Y-chromosome STRs in a set of 41 DNA samples from the 3 major U.S. population groups (African Americans, Caucasians, and Hispanics). The resulting sequence data, which were analyzed with STRait Razor v2.0, revealed 37 unique allele sequence variants that have not been previously reported. Of these, 19 sequences were variations of documented sequences resulting from the presence of intra-repeat SNPs or alternative repeat unit patterns. Despite a limited sampling, two of the most frequently-observed variants were found only in African American samples. The remaining 18 variants represented allele sequences for which there were no published data with which to compare. These findings illustrate the great potential of MPS with regard to increasing the resolving power of STR typing and emphasize the need for sample population characterization of STR alleles.
PMID: 26391384 [PubMed - as supplied by publisher]
Two-week normobaric intermittent-hypoxic exposures stabilize cerebral perfusion during hypocapnia and hypercapnia.
Two-week normobaric intermittent-hypoxic exposures stabilize cerebral perfusion during hypocapnia and hypercapnia.
Exp Biol Med (Maywood). 2015 Jul;240(7):961-8
Authors: Zhang P, Shi X, Downey HF
The effect of moderately extended, intermittent-hypoxia (IH) on cerebral perfusion during changes in CO2 was unknown. Thus, we assessed the changes in cerebral vascular conductance (CVC) and cerebral tissue oxygenation (ScO2) during experimental hypocapnia and hypercapnia following 14-day normobaric exposures to IH (10% O2). CVC was estimated from the ratio of mean middle cerebral arterial blood flow velocity (transcranial Doppler sonography) to mean arterial pressure (tonometry), and ScO2 in the prefrontal cortex was monitored by near-infrared spectroscopy. Changes in CVC and ScO2 during changes in partial pressure of end-tidal CO2 (PETCO2, mass spectrometry) induced by 30-s paced-hyperventilation (hypocapnia) and during 6-min CO2 rebreathing (hypercapnia) were compared before and after 14-day IH exposures in eight young nonsmokers. Repetitive IH exposures reduced the ratio of %ΔCVC/ΔPETCO2 during hypocapnia (1.00 ± 0.13 vs 1.94 ± 0.35 vs %/mmHg, P = 0.026) and the slope of ΔCVC/ΔPETCO2 during hypercapnia (1.79 ± 0.37 vs 2.97 ± 0.64 %/mmHg, P = 0.021), but had no significant effect on ΔScO2/ΔPETCO2. The ventilatory response to hypercapnia during CO2 rebreathing was significantly diminished following 14-day IH exposures (0.83 ± 0.07 vs 1.14 ± 0.09 L/min/mmHg, P = 0.009). We conclude that repetitive normobaric IH exposures significantly diminish variations of cerebral perfusion in response to hypercapnia and hypocapnia without compromising cerebral tissue oxygenation. This IH-induced blunting of cerebral vasoreactivity during CO2 variations helps buffer excessive oscillations of cerebral underperfusion and overperfusion while sustaining cerebral O2 homeostasis.
PMID: 25504012 [PubMed - indexed for MEDLINE]
Glutaredoxin 1 (Grx1) Protects Human Retinal Pigment Epithelial Cells From Oxidative Damage by Preventing AKT Glutathionylation.
Glutaredoxin 1 (Grx1) Protects Human Retinal Pigment Epithelial Cells From Oxidative Damage by Preventing AKT Glutathionylation.
Invest Ophthalmol Vis Sci. 2015 May;56(5):2821-32
Authors: Liu X, Jann J, Xavier C, Wu H
PURPOSE: Glutaredoxin 1 (Grx1) belongs to the oxidoreductase family and is a component of the endogenous antioxidant defense system. However, its physiological function remains largely unknown. In this study, we investigated whether and how Grx1 overexpression protects the retinal pigment epithelial (RPE) cells against H2O2-induced apoptosis.
METHODS: Human retinal pigment epithelial (ARPE-19) cells were transfected with either a Grx1-containing plasmid or an empty vector. Primary human RPE cells were transfected with Grx1 small interfering RNA (siRNA) or scrambled siRNA. Cell viability was measured with the WST8 assay. Apoptosis was quantitatively measured by annexin V/propidium iodide (PI) double staining. The level of protein glutathionylation (PSSG) was measured by immunoblotting using anti-PSSG antibody. Protein kinase B (AKT) activation was examined by Western blot. Protein kinase B glutathionylation was detected by immunoprecipitation followed by immunoblotting with anti-PSSG antibody.
RESULTS: Glutaredoxin 1 overexpression protected ARPE-19 cells from H2O2-induced cell viability loss. Conversely, Grx1 gene knockdown sensitized primary human RPE cells to H2O2. Assessment of apoptosis indicated that cells transfected with the Grx1-containing plasmid were more resistant to H2O2 with fewer cells undergoing apoptosis as compared to empty vector-transfected cells. Hydrogen peroxide-induced PSSG accumulation was also attenuated by Grx1 enrichment. Furthermore, Grx1 overexpression prevented H2O2-induced AKT glutathionylation, resulting in a sustained phospho-AKT elevation in RPE cells.
CONCLUSIONS: Glutaredoxin 1 can protect RPE cells against oxidative stress-induced apoptosis. The mechanism of this protection is associated with its ability to stimulate the phosphorylation of AKT by preventing AKT glutathionylation. Considering Grx1's protective abilities in RPE cells, Grx1 could be a potential pharmacological target for retinal degenerative diseases.
PMID: 25788646 [PubMed - indexed for MEDLINE]
M2b macrophage elimination and improved resistance of mice with chronic alcohol consumption to opportunistic infections.
M2b macrophage elimination and improved resistance of mice with chronic alcohol consumption to opportunistic infections.
Am J Pathol. 2015 Feb;185(2):420-31
Authors: Ohama H, Asai A, Ito I, Suzuki S, Kobayashi M, Higuchi K, Suzuki F
Alcohol abuse was found to predispose persons to opportunistic infections. In this study, we tried to improve the host antibacterial resistance of chronic alcohol-consuming (CAC) mice to opportunistic infections. Bactericidal macrophages with functions to produce IL-12 and to express mRNAs for CXCL9 and inducible nitric oxide synthase (M1 macrophages) were characterized as the main effector cells in host antibacterial innate immunities against infections with opportunistic pathogens. However, CAC mice were found to be carriers of M2b macrophages [macrophages with functions to produce IL-10 and to express mRNAs for CD163, chemokine ligand (CCL)1, and LIGHT (homologous to lymphotoxin, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for high-voltage electron microscopy on T cells)], which were inhibitory on macrophage conversion from resident macrophages to M1 macrophages. Under treatment with CCL1 antisense oligodeoxynucleotides, a specific inhibitor of M2b macrophages, CAC mouse macrophages reverted to resident macrophages, and M1 macrophages were induced by a bacterial antigen from macrophages of CAC mice that were previously treated with the oligodeoxynucleotides. Opportunistic infections (enterococcal translocation and Klebsiella pneumonia) in CAC mice were completely controlled by CCL1 antisense oligodeoxynucleotides. These results indicate that certain opportunistic infections in alcoholics are controllable through the modulation of M2b macrophages.
PMID: 25485859 [PubMed - indexed for MEDLINE]
Massively parallel sequencing of forensically relevant single nucleotide polymorphisms using TruSeq™ forensic amplicon.
Massively parallel sequencing of forensically relevant single nucleotide polymorphisms using TruSeq™ forensic amplicon.
Int J Legal Med. 2015 Jan;129(1):31-6
Authors: Warshauer DH, Davis CP, Holt C, Han Y, Walichiewicz P, Richardson T, Stephens K, Jager A, King J, Budowle B
The TruSeq™ Forensic Amplicon library preparation protocol, originally designed to attach sequencing adapters to chromatin-bound DNA for chromatin immunoprecipitation sequencing (TruSeq™ ChIP-Seq), was used here to attach adapters directly to amplicons containing markers of forensic interest. In this study, the TruSeq™ Forensic Amplicon library preparation protocol was used to detect 160 single nucleotide polymorphisms (SNPs), including human identification SNPs (iSNPs), ancestry, and phenotypic SNPs (apSNPs) in 12 reference samples. Results were compared with those generated by a second laboratory using the same technique, as well as to those generated by whole genome sequencing (WGS). The genotype calls made using the TruSeq™ Forensic Amplicon library preparation protocol were highly concordant. The protocol described herein represents an effective and relatively sensitive means of preparing amplified nuclear DNA for massively parallel sequencing (MPS).
PMID: 25408291 [PubMed - indexed for MEDLINE]
Utility of amplification enhancers in low copy number DNA analysis.
Utility of amplification enhancers in low copy number DNA analysis.
Int J Legal Med. 2015 Jan;129(1):43-52
Authors: Marshall PL, King JL, Budowle B
One parameter that impacts the robustness and reliability of forensic DNA analyses is the amount of template DNA used in the polymerase chain reaction (PCR). With short tandem repeat (STR) typing, low copy number (LCN) DNA samples can present exaggerated stochastic effects during the PCR that result in heterozygote peak height imbalance, allele drop out, and increased stutter. Despite these effects, there has been little progress toward decreasing the formation of stutter products and heterozygote peak imbalance effects during PCR. In an attempt to develop a more robust system that is less refractory to stochastic effects, the PCR additives, betaine, DMSO, PEG, and PCRboost®, were investigated on low-quantity DNA samples. The effects of the additives were assessed by evaluating STR typing results. Of the four additives, the only positive effects were observed with betaine treatment. Betaine, at a final concentration of 1.25 mol/L, was found to improve the robustness of the amplification, specifically by decreasing stutter in a dual locus system. In contrast, the addition of 1.25 mol/L betaine to commercial STR amplification kits did not affect stutter ratios. However, the addition of betaine did lead to increased yield of PCR products in all commercial kits tested. The results support that betaine can improve amplification efficiency of LCN DNA samples.
PMID: 24848516 [PubMed - indexed for MEDLINE]
Peak Plantar Shear and Pressure and Foot Ulcer Locations: A Call to Revisit Ulceration Pathomechanics.
Peak Plantar Shear and Pressure and Foot Ulcer Locations: A Call to Revisit Ulceration Pathomechanics.
Diabetes Care. 2015 Sep 14;
Authors: Yavuz M, Master H, Garrett A, Lavery LA, Adams LS
PMID: 26370381 [PubMed - as supplied by publisher]
Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives.
Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives.
J Pharmacol Exp Ther. 2015 Aug;354(2):103-10
Authors: Gatch MB, Dolan SB, Forster MJ
Synthetic cathinones, often sold as "bath salts," are a popular class of recreational drugs used as quasi-legal alternatives to cocaine, methamphetamine, and methylenedioxymethamphetamine. The increased prevalence and health consequences of synthetic cathinone use has prompted regulatory agencies to control a number of these compounds; however, a broad class of analogous compounds known as the second-generation cathinones has been brought to the market to take the place of the banned synthetic cathinone derivatives. The current study aims to characterize the behavioral pharmacology of three pyrrolidinylated second-generation cathinones: 4-methyl-α-pyrrolidinopropiophenone (4'-MePPP), α-pyrrolidinopropiobutiophenone (α-PBP), and α-pyrrolidinopentiophenone (α-PVP). Locomotor activity was tested in mice over an 8-hour period. The discriminative stimulus effects of these compounds were tested in rats trained to discriminate either cocaine or methamphetamine. The rewarding effects of these drugs were assessed in mice using conditioned place preference. Both α-PBP and α-PVP produced long-lasting increases in locomotor activity across a wide range of doses, whereas 4'-MePPP produced locomotor stimulation only at 30 mg/kg. Both α-PBP and α-PVP fully substituted for the discriminative stimulus effects of both cocaine and methamphetamine, whereas 4'-MePPP substituted fully for the discriminative stimulus effects of methamphetamine only. Both α-PBP and α-PVP produced conditioned place preference in an inverted U-shaped dose effect, whereas 4'-MePPP did not produce conditioned place preference. These findings suggest that α-PBP and α-PVP are likely to be recreationally used and have potential for addiction and abuse, but 4'-MePPP may not.
PMID: 25998047 [PubMed - indexed for MEDLINE]
Risk of Intracranial Hemorrhage From Statin Use in Asians: A Nationwide Cohort Study.
Risk of Intracranial Hemorrhage From Statin Use in Asians: A Nationwide Cohort Study.
Circulation. 2015 Jun 9;131(23):2070-8
Authors: Chang CH, Lin CH, Caffrey JL, Lee YC, Liu YC, Lin JW, Lai MS
BACKGROUND: Reports of statin usage and increased risk of intracranial hemorrhage (ICH) have been inconsistent. This study examined potential associations between statin usage and the risk of ICH in subjects without a previous history of stroke.
METHODS AND RESULTS: Patients initiating statin therapy between 2005 and 2009 without a previous history of ischemic or hemorrhagic stroke were identified from Taiwan's National Health Insurance database. Participants were stratified by advanced age (≥70 years), sex, and diagnosed hypertension. The outcome of interest was hospital admission for ICH (International Classification of Diseases, Ninth Revision, Clinical Modification codes 430, 431, 432). Cox regression models were applied to estimate the hazard ratio of ICH. The cumulative statin dosage stratified by quartile and adjusted for baseline disease risk score served as the primary variable using the lowest quartile of cumulative dosage as a reference. There were 1 096 547 statin initiators with an average follow-up of 3.3 years. The adjusted hazard ratio for ICH between the highest and the lowest quartile was nonsignificant at 1.06 with a 95% confidence interval spanning 1.00 (0.94-1.19). Similar nonsignificant results were found in sensitivity analyses using different outcome definitions or model adjustments, reinforcing the robustness of the study findings. Subgroup analysis identified an excess of ICH frequency in patients without diagnosed hypertension (adjusted hazard ratio 1.36 [1.11-1.67]).
CONCLUSIONS: In general, no association was observed between cumulative statin use and the risk of ICH among subjects without a previous history of stroke. An increased risk was identified among the nonhypertensive cohort, but this finding should be interpreted with caution.
PMID: 25858194 [PubMed - indexed for MEDLINE]
Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.
Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.
Bioorg Med Chem Lett. 2015 Feb 1;25(3):519-23
Authors: Peng X, Wang Q, Mishra Y, Xu J, Reichert DE, Malik M, Taylor M, Luedtke RR, Mach RH
A series of 2-methoxyphenyl piperazine analogues containing a triazole ring were synthesized and their in vitro binding affinities at human dopamine D2 and D3 receptors were evaluated. Compounds 5b, 5c, 5d, and 4g, demonstrate high affinity for dopamine D3 receptors and moderate selectivity for the dopamine D3 versus D2 receptor subtypes. To further examine their potential as therapeutic agents, their intrinsic efficacy at both D2 and D3 receptors was determined using a forskolin-dependent adenylyl cyclase inhibition assay. Affinity at dopamine D4 and serotonin 5-HT1A receptors was also determined. In addition, information from previous molecular modeling studies of the binding of a panel of 163 structurally-related benzamide analogues at dopamine D2 and D3 receptors was applied to this series of compounds. The results of the modeling studies were consistent with our previous experimental data. More importantly, the modeling study results explained why the replacement of the amide linkage with the hetero-aromatic ring leads to a reduction in the affinity of these compounds at D3 receptors.
PMID: 25556097 [PubMed - indexed for MEDLINE]
Motivational interviewing fidelity in a community corrections setting: Treatment initiation and subsequent drug use.
Motivational interviewing fidelity in a community corrections setting: Treatment initiation and subsequent drug use.
J Subst Abuse Treat. 2015 Jul 29;
Authors: Spohr SA, Taxman FS, Rodriguez M, Walters ST
INTRODUCTION: Although substance use is common among people in the U.S. criminal justice system, treatment initiation remains an ongoing problem. This study assessed the reliability and predictive validity of the Motivational Interviewing Treatment Integrity 3.1.1. (MITI) coding instrument in a community corrections sample.
METHODS: We used data from 80 substance-using clients who were participating in a clinical trial of MI in a probation setting. We analyzed 124 MI counseling sessions using the MITI, a coding system for documenting MI fidelity. Bivariate associations and logistic regression modeling were used to determine if MI-consistent behaviors predicted substance use or treatment initiation at a 2-month follow-up.
RESULTS: We found a high level of agreement between coders on behavioral utterance counts. Counselors met at least beginning proficiency on most MITI summary scores. Probationers who initiated treatment at 2-month follow-up had significantly higher ratings of clinician empathy and MI spirit than clients who did not initiate treatment. Other MITI summary scores were not significantly different between clients who had initiated treatment and those who did not. MI spirit and empathy ratings were entered into a forward logistic regression in which MI spirit significantly predicted 2-month treatment initiation (χ(2) (1)=4.10, p<.05, R(2)=.05) but counselor empathy did not. MITI summary scores did not predict substance use at 2-month follow-up.
CONCLUSIONS: Counselor MI-consistent relational skills were an important predictor of client treatment initiation. Counselor behaviors such as empathy and MI spirit may be important for developing client rapport with people in a probation setting.
PMID: 26365536 [PubMed - as supplied by publisher]


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Author has written 14 stories for Percy Jackson and the Olympians, Hunger Games, and Supernatural.
My name is Julie and I write stuff. Mainly a Game of Thrones and The Walking Dead fanatic.
Visit me on tumblr, URL daenerystargaryene.
Serendipity Series (A PJ&O, Twilight, and Harry Potter Fanfic Series):
Book 1 - Another Sparkly, Magical Greek Tragedy (COMPLETE)
Book 2 - Her Invisible Mind (ABANDONED & UNCOMPLETE)
NOTE: These stories were my first attempts at FF, so the chapters were rather short, as my writing was kind of crappy. The only reason these weren't deleted is because of sentimental value.
Panem's Games Trilogy (A Hunger Games Fanfic Series):
Book 1 - The Girl With The Mockingjay Pin (Formerly titled: Looking Through Gray Stained Glass)
Book 2 - The Girl Who Played With Fire (Formerly titled: The Mortem Circus) (HIATUS)
Book 3 - The Girl Who Kicked Panem's Capitol (NOT STARTED)
Single Stories:
Assbutts in Love (Supernatural) (WIP)
The Missing Puzzle Pieces (Percy Jackson)
Under the Mistletoe (Percy Jackson) (ABANDONED & UNCOMPLETE)
One Shots:
A Wicked Halloween (Percy Jackson)
Here Is The Place Where I Love You (The Hunger Games)
Always and Forever (The Hunger Games)
Goodbye To His Catnip (The Hunger Games)
Skinny Love (The Hunger Games)
Till Death Do Us Part (The Hunger Games)
Song Fics (Always one-shots, unless otherwise noted):
I'd Lie (Percy Jackson)
A Scarlet Letter (Percy Jackson)
The One That Got Away (The Hunger Games)
Wedding Bells (The Hunger Games)


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14K White Gold / Citrine / Diamond
Sterling Silver / Citrine
14K Yellow Gold / Citrine / Yellow Sapphire
14K White Gold / Citrine / Diamond
14K White Gold / Citrine
14K Rose Gold / Citrine
14K White Gold / Citrine / Yellow Sapphire
Palladium / Citrine / White Sapphire
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18K Yellow Gold / Citrine
Sterling Silver / Citrine
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Appalachian State University women's golf finished up play in the Great
Joe Stilin from the University of Texas and a rookie with Reebok/Zap Fitness
Fans from around the Sun Belt Conference have selected the new league's
Remember that song by The Mamas and the Papas. The lyrics best describe just how cruel Monday's can
The Watauga High boy's soccer team continued its torrid pace by knocking off Hickory 4-1 in a
The Watuaga High boy's and girl's cross country teams traveled to Greenville, S.C., Saturday for the Furman Classic. The WHS girls were led by Kathleen Mansure, who


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Browsing by Author "Wilson, Francis"
Now showing items 1-2 of 2
Only connect : unemployment and poverty; formal and informal economic activity in a divided world. The Role of the informal sector in alleviating unemployment and poverty in the third world. Øyen, Else; Wilson, Francis (Pontifical Academy of Social Sciences. Vatican City, 1999)
The polyscopic landscape of povert research. "State of the art" in International Poverty Research. An overview and 6 in-depth studies. Øyen, Else; Andreassen, Bård Anders; Eide, Asbjørn; Ivo, Anete Brito Leal; Kildal, Nanna; Kulindwa, Kassim; Lomelí, Enrique Valencia; Moeshart, Jarichje; Solano, Carlos Barba; Sælen, Kirsti Thesen; Williams, Lucy; Wilson, Francis; Ziccardi, Alicia (Comparative Research Programme on Poverty (CROP), 2005)In August 2004 the Research Council of Norway announced tenders for a "State-of-the-art" report within international poverty research, with special focus on institutions and rights. The Research Council wanted the report ...


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The Durango Dharma Center (DDC) was formed in 1991 by a few individuals desiring support in their sitting practice. It is now home to many meditators of all levels of practice with classes for beginners, families, and those interested in deeper study of the Buddha's teachings. The DDC is Vipassana (Insight) oriented but welcomes meditators of any tradition.
One of the founding teachers at Spirit Rock Meditation Center – Howard Cohn – will lead a non-residential retreat at the Dharma Center, October 9 – 11, 2015. His subject – A View as Wide as the Sky – will awaken retreat participants to the sky-like nature of our minds and remind them that our natural awareness is primordially pure, open and free. Sitting and walking in silence, participants will – as the poet Donald Babcock says – "Ease ourselves into the boundless, right where life touches us." This retreat is suitable for meditators at all levels.
Dates and Times: Friday, October 9, 7-9 p.m.; Saturday, October 10, 9 a.m. to 5 p.m.; Sunday, October 11, 9 a.m. to 4 p.m.
Venue: Durango Dharma Center, 208 County Road 250, at intersection with 32nd Street
Cost: Sliding scale of $100 - $200 for entire weekend, with $20 early payment discount before September 18. Scholarships available by contacting Tammy Hoier, firstname.lastname@example.com or phone (970) 403-3449. Opportunity to practice dana (generosity) for Howard at end of retreat.
Benefit: Fees support Durango Dharma Center. Make checks payable to Durango Dharma Center.
Register: Online here or by mail to Liz Cosgrove, 1820 Glenisle Avenue, Durango, CO 81301
Questions: Contact Tami Hoier, email@example.com or phone (970) 403-3449
The physical address of the Durango Dharma Center is 208 CR 250. It is located at the intersection of 32nd Street and CR 250 (East Animas Rd). Turn onto Metz Lane and pull into the parking lot, your first left.
The Durango Dharma Center • 208 CR 250 • P.O. Box 1631, Durango, CO 81302 • email@example.com


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J by Jasper Conran Designer navy large checked shirt
Item No.0450102662
Item No.0450102662
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From J Jeans by Jasper Conran, this long sleeved designer shirt has a large navy and grey check with two buttoned down chest pockets and a single button cuff. Also available in big and tall sizes.
UK Home Delivery Free (UK orders over £30) or £3.49
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Subject to exceptions, Debenhams is happy to exchange or refund your purchase within 28 days of delivery. Please check here for more details on our returns policy and exceptions.


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Voters in Paraguay have a chance to solidify democracy Sunday in a presidential election that pits a candidate from a political party that governed for more than six decades against a hopeful from a party that currently holds the presidency, according to a former U.S. ambassador to the South American country.
"Paraguay has been struggling to establish a genuine democracy since the overthrow of the long-lived dictator Alfredo Stroessner in 1989," Timothy L. Towell wrote in an analysis of the political conditions in the landlocked nation. "And the recent fate of its first president not belonging to [Stroessner's] Colorado Party in six decades, Fernando Lugo, has not made the task any easier."
Stroessner imposed a brutal regime in Paraguay from 1954 until he was overthrown in a military coup 35 years later.
Mr. Lugo, a former Roman Catholic bishop, ran as a candidate from the left-wing Christian Democratic Party and broke the stranglehold of the Colorado Party in the 2008 election. However, he was impeached on nepotism and other charges, and removed from office last year, allowing Vice President Federico Franco to succeed him.
Mr. Towell, U.S. ambassador in Paraguay from 1988 to 1991, described Mr. Lugo as "charismatic and somewhat eccentric."
Sunday's election will be a contest between Colorado Party candidate Horacio Cartes, a 56-year-old banker, and Efrain Alegre, a 49-year-old lawyer from the Liberal Party.
Mr. Cartes has been weakened by revelations of a U.S. government investigation into money-laundering charges, and the polls show the race is tightening.
"Despite the allegations against Cartes, it is to be hoped that the Colorado Party will continue to evolve away from its past associations with authoritarianism and corruption," Mr. Towell said. "And the question for the Liberals is whether in Alegre they have found a candidate who, if elected, would show the moderation and ability to sustain legislative support sufficient to serve out a successful term."
The most important thing Paraguayans could demonstrate Sunday is an ability to change political parties in a peaceful election, Mr. Towell said.
"This year's race in Paraguay will be a competitive one, and, at a minimum, it will be the people of that country who make the choice," he said.
Israel is worried that U.S. arms could fall into the hand of Islamic terrorists in Syria if the Obama administration sends weapons to the rebels fighting to overthrow President Bashar Assad, the Israeli ambassador in Washington said this week.
"All we are saying is that the rebels should be very carefully vetted," Ambassador Michael Oren told Jewish reporters in an interview to mark Israel's independence day.
A jihadist guerrilla faction called the Nusra Front last week announced an alliance with al Qaeda, causing the main rebel force, the Free Syrian Army, to renounce all ties to the Islamists, who are considered among the most effective fighters against the Syrian army.
Mr. Assad regularly has claimed that terrorists are behind the 2-year-old uprising that has taken the lives of more than 70,000 lives, according to many estimates.


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The purpose of this OECD Japan seminar is to enable stakeholders in ECEC such as policy makers, academics, professional bodies, practitioners, parents, media, and journalists at local (sub-national), national, regional and international level to huddle together and canvass the issues.
English, , 544kb
Many strengths are apparent in the Chinese system for vocational education and training in upper secondary schools. The strengths include: The establishment of 9 year schooling with almost all children in China now completing lower secondary education.
English, , 908kb
Reviews of Higher Education in Regional and City Development are the OECD's vehicle to mobilise higher education for economic, social and cultural development of cities and regions. They analyse how higher education systems impact local and regional development and assist in improving this impact.
Pointers for Policy Development are designed for busy policymakers and others wanting to know the OECD's policy advice on different education and training topics within each of the thematic reviews carried out by the Education and Training Policy Division.
This paper makes an in-depth comparison of the PISA (OECD) and TIMSS (IEA) mathematics assessments conducted in 2003. First, a comparison of survey methodologies is presented, followed by an examination of the mathematics frameworks in the two studies. The methodologies and the frameworks in the two studies form the basis for providing explanations for the observed differences in PISA and TIMSS results. At the country level, it
Czech, , 2,062kb
Net migration to OECD countries has tripled since 1960. Today, immigrant students comprise 10 to 20% of the student population in many OECD countries. Some countries have long histories of immigration; others have experienced an unprecedented increase in the last decade.
PISA 2009 Assessment Framework - Key Competencies in Reading, Mathematics and Science presents the theory behind the development of the PISA 2009 survey, the results of which will be released in December 2010.
The Programme for International Student Assessment (PISA ) is an internationally standardised assessment that was jointly developed by participating countries and administered to 15-year-olds in schools.
English, , 2,938kb
TALIS is the first international survey to focus on the working conditions of teachers and the learning environment in schools. It focuses on four main research areas: school leadership; professional development; teacher appraisal and feedback; and teaching practices, beliefs and attitudes.


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Travolta employee testifies at Bahamas trial
Published: Tuesday, September 29, 2009 at 9:38 a.m.
Last Modified: Tuesday, September 29, 2009 at 9:40 a.m.
NASSAU, Bahamas - A paramedic who treated John Travolta's son in the Bahamas threatened to go to the media with private information unless the movie star paid $25 million, an employee of the actor testified Monday.
Ronald Zupancic, a security specialist for Travolta, said he was the one who told his boss of the alleged demand in the days following his autistic son's death in January.
He said ambulance driver Tarino Lightbourne contacted Travolta's attorneys through a lawyer, former Bahamas Sen. Pleasant Bridgewater, who is also facing extortion charges.
"He had a document that he contended was incriminating to Travolta," Zupancic told the jury.
The document, which Travolta signed, would have cleared the ambulance driver of liability if the family refused to send 16-year-old Jett Travolta to the hospital. The actor testified last week that he initially wanted his son flown to Florida for treatment after a seizure on Jan. 2 that resulted in Jett's death.
But Jett was treated in the Bahamas, and it is unclear why the defendants allegedly believed Travolta would pay to keep the document private.
The trial began Sept. 21 and is expected to last several weeks. Travolta is expected to give further testimony later in the trial.
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Tom Marshburn is one of three astronauts who will chat with Earthbound fans via Google+. (NASA photo)
NASA, the agency that brought you the first ever tweet from space (2009) and a FourSquare check-in from Mars (2012), will host a Google+ Hangout live with the International Space Station on Feb. 22 from 10:30-11:30 a.m. Eastern time.
The Hangout is viewable on the NASA Google+ Page or NASA's YouTube channel.
During the hangout, astronauts aboard the space station -- Kevin Ford, Chris Hadfield and Tom Marshburn -- will team with astronauts on the ground to answer video questions from Google+ and Twitter users who use the hashtag #askAstro, and Facebook friends who post in a thread that will open the morning of the event.
NASA's website explains that "unique and original questions" are more likely to be selected.
In addition, NASA will ask real-time questions submitted by followers on Facebook, Twitter and Google+.
During the Hangout, astronauts will describe what life is like during their six-month stay to conduct science experiments and perform space station maintenance.
NASA is no stranger to combining social media, science and space.
Its Mars Curiosity rover - the famous mobile machine that checked into Mars on FourSquare -- has more than 1.2 million Twitter followers, and it is just one of more than 480 social media accounts NASA manages, according to the agency's deputy social media manager Jason Townsend.
In fact, the Curiosity rover is close to home compared to NASA's farthest reaching social media efforts. Almost 90,000 people follow the latest happenings of NASA's Voyager 1 & 2 spacecraft. Launched in the 1970s, they are the farthest manmade objects from Earth -- close to leaving our solar system at nearly 12 billion miles away.
Follow Marshburn and Hadfield on Twitter at: @AstroMarshburn and @Cmdr_Hadfield. Follow the Voyager space probes at @NASAVoyager and @NASAVoyager2.
Posted by Frank Konkel on Feb 20, 2013 at 12:10 PM
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The General Services Administration's Enterprise Infrastructure Solutions contract will anchor the agency's NS 2020 telecommunications strategy.
House and Senate both approve a measure to maintain funding at fiscal 2015 levels through Dec. 11.
The aviation regulator missed a Congressional deadline to develop rules of the sky-ways for drones.
Agency heads, acquisition officers and even CIOs don't need to be hard-core techies. FCW's four-part look at the expertise that's really required to make federal IT run.
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Massive open online courses can offer specialized IT instruction on a flexible schedule and on the cheap. That may not always mesh with government's preference for structure and certification, however.
The federal government craves more cybersecurity professionals. These six schools are helping meet that demand.
Former ACT president will take a job with Gartner, follow his spouse to Vienna, Austria.
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Fiona about leader and team mate, Hans Florine: "...to see a master climber go, and how fast; he was amazing to watch."
The drone that wears like a watch
Check what's new
The vital question: whether or not the ice would open sufficiently to release Endurance before the drift carried her into the most dangerous area
AI goes to altitude.
Made for people on the move.
Jamie Sharp, Tara Mulvany and Per Gustav Porsanger paddled 2000km in 71 days around polar bear country
"It was the first time I ran up The Nose with Steve Schneider that I realized how fun it was to cover huge amounts of vertical terrain"
The pressure of millions of tons of moving ice was crushing and smashing inexorably
33kg backpacks, no assistance/support, gruelling and idillic landscapes and rivers, wrong expedition footwear, impressions from 30 years ago...
Yngve Kristoffersen and Audun Tholfsen spent 353 days on the Arctic Ice - over winter
"There's nothing like 'total commitment' to focus your mind," says Fiona, who will be climbing with Hans Florine
Norwegian ski guide, Bengt Rotmo, sent over news
Hans Florine and Fiona Thornewill team up for El Capitan
Yachts require authorisation from a relevant authority, not only for the voyage itself but also to do any activities
On a mission to cross 20 Icefields of the world, the duo completed Stikine in Alaska: commitment and exposure to make it through
Shackleton and crew trapped in ice since January [1915]
Then and Now
Taking care of the dogs started long before they headed off
Southern Ocean point of reference for South Pole ski
A seemingly untouchable record broken, vicious wind storms, and crevassed end points
Facebook scraps support, Iridium scraps FB
Sarah McNair-Landry, Erik Boomer and 16 dogs completed their 4-month sled journey
North of Svalbard, 5.2 Mb
Tom Avery, Patrick Woodhead, George Wells (all UK) and Andrew Gerber (ZA)
Tanks and tubes, and turbulent thoughts
A story about super skiers chasing a dream on Greenland
9 days 19 hours 40 minutes over 610 km
The storm hit (100kph) halfway down the icefall, "we were so psyched on making it work that we would have crawled if necessary"
7 days 10 hours 20 min over 560km
During a risky recovery operation, a team of local volunteers and Canadian experts retrieved a body at the location of the accident
Author and rock climber, James MacKinnon joined Jerry Kobalenko, on a sledge-hauling expedition
The British team kited at night (photo) and for the Norwegian, beating the storm is priority to the record
A Norwegian duo climbed highest mountain and Brits started kiting
75 km, and the wind picked up
Patrick Woodhead, Tom Avery, George Wells and Andrew Gerber to kite-ski East-West coast-to-coast
Skidoo team left from Resolute Bay
A speed ski and speed kite-ski record attempt and an unsupported amputee
Loyal and dedicated dog Kimnik guarded the equipment against polar bears
Marc Cornelissen and Philip de Roo not found
No sign of Marc Cornelissen and Philip de Roo, except for their dog and sleds
Teodor Johansen and Paul Devaney filmed the avalanche and experience the big challenges of the small villages
Barneo Ice Camp closes
Crossing pressure ridges vs. gaining distance at high speed
Risk too high
Solo Thomas Ulrich making his way South from the North Pole to Canada
Darkness and then endless visibility: Redl - with cameraman, Marcus Fillinger
The only full distance skier set off to Canada today
"That first expedition remains the hardest for me, because I was alone, in frigid temperatures, into a headwind, I had no communications for 46 days and most importantly, I was learning everything for the first time."
Russian military conducts training near the North Pole. Flights resume from Longyearbyen.
"I have respect but no fear"
Landing gear failed. Thomas Ulrich still in Svalbard
Focus on now and lessons from the past, and custom-made equipment for the ice
One solo skier alone on the Ice
Nine teams from around the world have set off to drive the length of a frozen lake on vintage Ural motorbikes and sidecars
Explore Greenland in reality TV series
Eric McNair-Landry, Katherine Breen, Sarah McNair-Landry and Erik Boomer, modern day Canadians, and Nanook and his family in 1921
Co-founder of Icelandic Mountain Guides, led Adventure Consultants team to the South Pole
With 2 days to spare before their pick-up deadline, they completed the traverse in 74 days
The pic is fake, Szwed told home media. [Story updated]