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Third and final segment of episode 50.0 Faith. Host Zoe Sullivan and Catholic and Mormon and Muslim teens are joined by Jewish Teens to discuss persecution they have experienced and ...
The D.I.V.A.S. Promo
Book Recommendations from the Staff
Starving Yourself to Achieve the Impossible Figure of Barbie
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Faith 50.2
Second part of Forum 50.0 on Faith with host Zoe Sullivan and teens from different religions. What do you say about your faith? Sponsored by people who care: Layer3 Technologies & the Fenlon family
Forum 50.0 Host Zoe Sullivan talks with teens from several different faiths and religions. What do you say about your faith? Thank you to the Turkish Cultural Center, Saint Kateri Catholic Church and Church of Latter Day Saints for their assistance gathering guests for this episode. Sponsored by people who care: Layer3 Technologies & the […]
Teen Scientists 49.2
Part Two of Forum for 49.0 with Teen Scientists Host Zoe Sullivan talks with high school teens who've interned at RIT in Imaging Science and Remote Sensing. What do YOU say? Are you in the sciences? Join the discussion on the blog, also tweet us on Twitter, like us on Facebook, see our pics on […]
Teen Scientists
Forum 49.0 Host Zoë Sullivan talks with teens in the sciences ranging from Imaging Science to Computer Science to Biology, Molecular Biology and Genetic Engineering. If you're a sciencer, comment on the blog or tweet us, also check out Instagram & Tumblr & Pinterest. Sponsored by people who care: Layer3 Technologies & The Fenlon Family

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Marketing Consultants
Marketing Eye is a team of marketers, graphic designers, social media experts, public relations officers and journalists designed to service your business as though in-house.
Gain access to an award-winning marketing team who is dedicated to achieving the objectives detailed in your marketing strategy.
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Marketing Eye recruits industry-leading marketers who possess the technical and creative dynamic integral to elevating businesses to the next level.
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Very few, if any, US
manufacturers have embraced the idea of hydraulic-free, electrically powered
(e-powered) machines—even though many European factories have been trending in
that direction for quite some time. The concept is quite significant because nearly
every machine tool has a hydraulic system and would therefore benefit from the
switch to e-powered components. Full Article
It may be tempting to be
bullish about the long-term prospects for the automotive sector, given that US
auto sales are currently at record levels not seen in 15 years and production
capacity is tight from the rationalization during the last downturn. However, the auto industry, globally, remains a cyclical one, and
our firm predicts it could face a downturn in the US at the same time new
investment requirements ramp up— investments beyond traditional plant and
new-vehicle design.
Full Article


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Sheikh Mujibur Rahman
Md Moshiur Rahman
under this new national policy, the PPP Office was established as a separate, autonomous office under the Prime Minister's Office to support sector line ministries to facilitate identification, development and tendering of PPP projects to international standards. A PPP Unit under the Ministry of Finance was established to foster an environment of fiscal responsibility and sustainability in PPP projects.


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Home ⋅ Thank You Notes and Photo Baby Thank You Cards ⋅ Animals ⋅ Cars & Trains ⋅ Favorite Characters
"The product is of good quality paper that does not look cheap. I would recommend this product to friends and family for it's superior quality."
"Fun & Funky design that is good for everyone in our family from the kids to the adults all year round. We'll be reordering. It would be absolutely perfect if it could be modified to say "A note from" or something like that so you aren't limited to sending as a thank you note, but not a big deal as we send mostly thank yous."
"This is a very nice card. The card stock is heavy, like other Tiny Prints cards. This particular piece is nice because it is relatively simple and leaves a lot of space to write the note."
"Rich, beautiful color and printing. Paper quality is superb. A stunning, elegant notecard for all ages and occasions. Definitely going to grow with my daughter and so glad we ordered a large number!"
"My husband and I are expecting our first child in August. We wanted to get unique thank you notes for the special gifts we received for our little one. Instead of putting our son's name, we put the nickname we've gave him at the start of the pregnancy! We're ordering the same cards after our son arrives with his full name on them. We've gotten so many compliments on the card and the idea to use his nickname until he makes his arrival."
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Fairway Homes
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Rocky Mount, NC 27804
- Carolina Custom Homes of Burlington
- If quality matters...Welcome Home!
- 2450 N Church St, Burlington, NC 27217
View Website
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We set out to revolutionize the mortgage industry by opening Paramount Equity Mortgage in 2003. By bringing a new level of competitive pricing, speed of transaction, and ethical education to our customers, we've been honored to serve the unique needs...Read more
96% of our customers would recommend this lender. (25 of 26)
After a $500 appraisal fee and Paramount having me close out my charge accounts they changed their minds at the last minute on refinancing my home . It was very disappointing not to mention throwing away $500 for which there was no refund.
By: Rolinda (Citrus Heights, CA)Reviewed On:August 14, 2015
Was this review helpful?
I went through the process of refinancing with Paramount Equity and found them highly professional and client oriented with excellent customer service. My whole process went very well and closing was done at my full satisfaction. It will be unfair if don't mention Mr. Ryan's absolutely professional and cooperative handling. God bless home Equity. Muhammad
By: Ryan (New Jersey)Reviewed On:July 7, 2015
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While refinancing a mortgage is always dreaded, David Nuzbach and Brian Reid made the experience painless quick and no nonsense. They were professional and on top of everything very quick on responding and following up. Excellent job gentlemen.
By: TanG (Hopatcong, New Jersey)Reviewed On:July 2, 2015
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It was a pleasure working with Ryan S. he was very helpful in walking me through the process to refinance my VA mortgage. He made the process as smooth as possible, and did an outstanding job communicating with me throughout.
By: Mike816 (San Antonio TX)Reviewed On:June 27, 2015
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I recommend Paramount Equity Mortgage to anyone interested in saving money. Marques Wood and his team at Paramount worked diligently with me in getting a lower interest rate which will save me thousands. Thanks Marques for providing outstanding service and making it easy.
By: WARMupman102 (Bakersfield California)Reviewed On:May 28, 2015
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They called to let me know of a great opportunity to refinance my home and gave me a great deal on the loan as a repeat customer. Recommend them for a mortgage or refinance.
By: Greg (San Diego, CA)Reviewed On:April 28, 2015
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Paramount and Ramon, in particular, did an exceptional job on our refinance. The frequency and quality of communication exemplifies excellent customer service. Process was easy and Ramon did everything he could to reduce the work on our end. Thanks very much - highly recommend.
By: jerrunning (Cool, CA)Reviewed On:March 22, 2015
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Don't go to a "Big Box Bank" for a loan, go to Paramount Equity. I know… Paramount Equity performed a refinance for me that a Big Box Bank was not able to do. We contacted Paramount Equity about two duplexes that we were looking to refinance to a lower rate. I was hooked up with Brooke Noble my Mortgage Specialist and she was exactly that, after sending our tax information and all other requested documentation, Brooke and her Supervisor looked over the information and there were some challenges, our debt to income ratio was high (some people are self employed) yet Brooke felt that we had a good loan. She let me know within two days of receiving my information! Brooke explained all the options to me (buying down the rate) and we discussed the process (how the loan would work, who I would be talking to next and when they would be contacting me). The loan was then given to Paul Dudzik my Closing Coordinator who did a fantastic job getting my loan closed. Brooke stayed with me throughout the process and I really consider her a friend. I am not in the habit of jumping on a soap box, but listen up people, Paramount Equity will find a loan for you, if there is a lender that can do it-it's Paramount Equity. Thank-you for saving me $373 a month!
By: SAtt (Forest Grove, OR)Reviewed On:September 25, 2013
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When developers and pool builders collaborate, the results are cool, code-compliant community pools
High costs, long waits and increased scrutiny are causing construction trades to band together.
On fiberglass pools, tile can go beyond the waterline. Here's how to apply the material to the shell correctly.
A company founded in Chile that engineers giant swimming pools is working with developers in the U.S.
Accused of leaving several pools unfinished, the former Phoenix institution and its sister company cannot build for now.
Despite some regional challenges, builders across the country expect this to be a breakout year.
The nationwide adoption of the International Swimming Pool & Spa Code would put all builders on an even playing field and ensure a standard of safety for consumers
They grew up skating empty pools. Today, they're building them.
After nearly two decades, the education group drops the 3 from its name
With its second pool-industry acquisition, a company relatively new to aquatics seeks to become a top player in the field.
Copyright ©
2015 Hanley Wood Media, Inc. All rights reserved.


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The GPA® Classic Pro Helmet** blends classic styling with technical advantages. Now available with a smooth matte outer surface, this GPA helmet has a high-density polystyrene inner shell and an outer shell covered in synthetic suede and a polyethylene foam nape protector. **ASTM F1163-04a/SEI Certified.
The IRH® Elite Ultra Helmet** is the next generation Elite. IRH's best-selling helmet is updated with a smooth leather covering with matte finished vents. This low-profile riding helmet has a ventilated wrap-around harness and top, side and rear vent ports for optimal air circulation.**ASTM F-1163-04a/SEI Certified.
The Tipperary Sportage 8500 helmet is loaded with all of the same feature that made the original so popular. This is an exceptionally light and comfortable riding helmet. Featuring superior impact resistance and a vent system with increased airflow, this helmet will keep you safe and cool on all of your rides. **ASTM F-1163-04a/SEI Certified.


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false pdp {"scheme":"product1_cr"}
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Rated 4.6 out of 5 by 20 reviewers.
Rated 5 out of 5 by soho AWESOME This is a great product. It's completely hidden, just blends right in with the garland. Can't believe great solution for such a low cost. December 8, 2011
Rated 5 out of 5 by fungrandma1 Just what I needed I finally found garland ties on Improvements.com that work great--thank you Improvements!!! November 20, 2012
Rated 5 out of 5 by GigiGirl Best Ever!! I just put my bannister garland up and it was so easy, so fast, that with my spare time I decided to write a review!! These ties made the process so fast and easy, they look great. And then I found I could use the ties to camouflage some wires connecting tree lights. Eyesore gone!! Where have you been all my life!!! November 29, 2012
Rated 5 out of 5 by catgrandma Perfect look and size Was wondering how I was going to attach my outside garland to my porch railing which is wide until I found this product. What a novel and useful idea. Especially the longer 18" ties which are hard to find. Can't wait to use next Christmas. February 6, 2014
Product:433709-Noble Fir Garland Ties-Set of 20


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What people say about Anne Penman
The whole experience of sitting in Anne's big leather chair and getting lasered is amazing!
Karen Ronald
Therapies and Locations
Stop Smoking Program
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Glasgow Scotland


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Interactive Seating Charts
Unfortunately, we do not currently have
a seating chart for Blue Nile.
Blue Nile532 Frenchmen St.
New Orleans, LA 70116
Upcoming Events
Oct 31
Sat 7:00 PM
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Sat 11:00 PM
About Seatgeek
We scour the web's major ticket sites and aggregate inventory into one place. Our Deal Score helps you identify the best ticket deals available for each event.Learn more about SeatGeek


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Will Smith and Sheree Zampino
Smith divorced Zampino in 1995, after three years of marriage, at the peak of his Fresh Prince fame. The couple's parting was mostly amicable, though Smith later expressed regrets. "It's the only thing in my life I consider a failure," he said. "If you don't mean 'til death do us part,' don't say it." All's well that ends well, though. Smith went on to marry Jada Pinkett with Zampino's blessing and the two women, along with their collective children, remain close.
(Photo: Ron Galella, Ltd./WireImage)
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Don't Mess With My Girl: Celebs Who Defended Bae10/08/2015
Celebrity Birthdays: Toni Braxton Celebrates!10/07/2015
You Gotta Have It: Things to See, Hear and Cop This Month10/07/2015
Where Are They Now: The Cast of Bamboozled10/06/2015
Every Time the Obamas Shut Down the Kardashians10/05/2015
Walk It Out: Amber Rose's LA SlutWalk10/03/2015
Out and About: EJ Johnson Is Gender-Bending Fab in LA10/02/2015
Quotes: Young Thug Thinks Lil Wayne Wants to Be Him10/02/2015
Oh My Goodness: Sheneneh's Best Quotes10/01/2015
Celebrity Birthdays: T-Pain Celebrates!09/30/2015
Wendy Williams's Most Famous Feuds09/29/2015
Suddenly Single: Splits We Didn't See Coming09/28/2015
Out and About: Rick Ross and Lira Galore Are Crazy in Love09/25/2015
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Celebrity Birthdays: Jason Derulo Celebrates!09/21/2015
No Love: Celebs Who Don't Support Caitlyn Jenner09/18/2015
Out and About: Is Drake Buying Diamonds for Serena?09/18/2015
Quotes: Terrence Howard 'Lost His Mind' on His Ex-Wife09/18/2015
Break the Internet: Social Media Frenzies09/17/2015
Girl, Bye: Ten Times Black Women Had Enough of the Media09/16/2015
No H8: Celebs Accused of LGBT-Phobia09/15/2015
Celebrity Birthdays: Nas Celebrates!09/14/2015
Out and About: Spotlight on KimYe at Rihanna's NYFW Party09/11/2015
Quotes: Taraji P. Henson Tears Up Over Racism in Hollywood09/11/2015
Gotta Love New York: Celebs From the Big Apple09/11/2015
Nip and Tuck: Celebrity Plastic Surgery09/10/2015
Unjust: Celebs Who Have Been Racially Profiled09/10/2015
Players' Club: Men Who Have Been Around the Block09/09/2015
Cinemania: Must-See Movies in September09/08/2015


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Home » Santa Fund » Donate to help
Presents organized by ages guarantee Christmas smiles
Volunteer Kristen Greenwood catches a set of toys while keeping the stations stocked during the Salvation Army Toy Shop in Manchester on Friday. (David Lane/Union Leader)
Volunteer Joey Maher of Bedford carries bags of toys after helping to pull an order at the Salvation Army Toy Shop in Manchester on Friday. (David Lane/Union Leader)
Volunteer Connor Robert of Bedford sorts piles of toys for distribution during the Salvation Army Toy Shop at the Radisson in Manchester on Friday. (David Lane/Union Leader)
MANCHESTER - Mothers, and a few fathers, went Christmas shopping for their children on Friday at one-day Toy Shop at the Radisson Hotel that the Union Leader Santa Fund for the Salvation Army helps fill each year.
Salvation Army Lt. Herb Rader said 986 families were served by the Toy Shop, some with five or six children or more, and an additional 72 families were "adopted" by various organizations and businesses.
For the people going through the Toy Shop, picking out four toys for each child, plus stocking stuffers, there was a wide selection of toys, grouped by age, infants to 12 years.
Santa Fund families also got a grocery gift card and a bag of bread products from Freihofer Bakery. The bag of bread was a welcome surprise for one mother, who said: "My kids eat a lot of sandwiches."
To forestall any toy supply problems, Salvation Army personnel calculated the numbers and ages of children accepted for the program and made sure the toy supplies were appropriate for each age group.
Nina was delighted to pick out a Cabbage Patch doll for her daughter. "She's two and she likes babies," she said.
She was picking gifts for four children, ages one month to 11 years, and was happy to see the variety of gifts for all ages.
She has sought help from the Santa Fund before, but has also been in a position to handle the holidays on her own at times. "This year has been very tough," she said.
Lynn was looking for gifts for her five-month-old and her three- and six-year-olds. She was pleased to find an Elmo for one boy: "He loves Elmo." A tea set was perfect for her daughter, a "girly girl."
At the stuffed animal stop, she said: "My son likes Mickey Mouse," but when Mickey couldn't be found, Minnie was a good substitute. "He'll like that," she said, adding, "They all share them."
Popular names and toys were well represented, with Lego, Barbie, Candyland and Battleship among them. There were Easy Bake Ovens, still only in pink this year, but with blue, black and silver gender-neutral colors planned for next year.
There were skateboards, basketballs, digital cameras and digital music devices. There were stuffed animals for the youngest children and fingerless mittens for somewhat older youngsters who need their fingers free for touch phones and music players. There were hair dryers and board games.
The volunteers who set up the Toy Shop and often serve as escorts for shoppers, benefitted from the Radisson's allowing them to begin setting up the Toy Shop Wednesday.
But volunteer escort (and set-up person) Mario Pena would have been there helping anyway. "This is my fourth year," he said.
Pena works at the city Office of Youth Services and said the office does a lot with the Salvation Army and his boss supports volunteer work. But Pena especially likes working the Toy Shop because he likes seeing toys being selected for children to open on Christmas morning.
Another volunteer, tiny Sally Zyla Addison, was dragging a black plastic bag of toys almost as big as she is. A three-year veteran, she said she does it because: "It's the Christmas spirit brought to life."
It saddens her that so many of the people she accompanies say that they used to give and now they need help. "But it's for the kids," she said.
The Salvation Army buys toys with donations to the Santa Fund, more toys come from the annual motorcyle Toy Run in September, and still more come from sources like the "entry fee" Passaconnaway Country Club in Litchfield sets for participation in a special golf tournament.
Sometimes toy donations come with a personal message, like the one on a Lite Brite set that said the giver had received one from the Salvation Army as a child and now wanted someone else to get as much joy from the Lite Brite set as the giver had.
Donations to the Union Leader Santa Fund for the Salvation Army help with toys for the Toy Shop, sending city youngsters to away camp for a week in the summer, afterschool programs and Kids Cafe, holiday meals for seniors, and small gifts and visits to nursing home residents.
How to donate
Santa Fund donations can be made by completing the online form by clicking "Donate" below or send a check to:
You can also drop off the printed form in our newspaper and a donation in the Santa Fund box at the Union Leader, 100 William Loeb Drive in Manchester from 8 a.m. to 6 p.m., Monday through Friday. We will also have a donation drop box at the Intown Manchester Holiday Market on Thursday, November 29 and every Thursday in December.
Share a holiday greeting
With your donation, the Union Leader will publish a short holiday message in the newspaper. Just write it up exactly as you would have it appear, printing clearly, and mail it along with your donation. If you prefer to donate online, follow the link on the page following the transaction to submit a Christmas message.
The Union Leader Santa Fund is a community tradition that has supported the Salvation Army for more than 50 years. The Santa Fund was first established at the Post Office Fruit in Manchester after a chance 1959 meeting between the Salvation Army major and the then-editor of the Union Leader.
In its first year, the Santa Fund brought in $1,000 to support the Salvation Army's Christmas effort. Since then, the Santa Fund has raised nearly $6.8 million, thanks to the generosity of the community and local businesses. Santa Fund dollars continue to provide warm clothing, meals and toys during the holidays, as well as support Kids' Café, summer camps and other critical programs throughout the year. Last year's drive brought in over $240,000 – thanks to the generosity of local businesses and residents, bringing the lifetime total to nearly $6.8 million.
- House to vote on new speaker on Oct. 29 - 0
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Gappens resigns after almost a quarter century at NHMSREADER COMMENTS: 0
DWI license revocations
Gov. Hassan to run for U.S. Senate
Marc A. Hebert's Money Sense: You can't afford to skip an annual check of your credit report
Clinton to discuss guns at town hall event
Income tax debate: It is a great one to have
Paul Feely's City Hall: Three aldermen on the hot seat this Tuesday night, two with other family members paid by Manchester
Gov. Hassan to run for U.S. Senate
A routine response: Obama ignores the real problem when it comes to guns and mass murders
Hunting is big business in the Granite State
With the temps cooling off We've decided to bundle up a little and get outdoors anyway. The leaves are starting to put on their show so you'll be surrounded by New Hampshire's beauty no matter what...
All Weekend
Friday, 7 p.m.,
Saturday, 11 a.m., 3 p.m. and 7 p.m.,
Sunday, 12 p.m. & 4 p.m.
Saturday, 11 a.m. - 4 p.m.
Sunday, 11 a.m. - 5 p.m.


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text:
For nerds who enjoy cuddling.
Please feel free to start discussions, ask for advice etc. This group needs more activity!
Members: 93
Latest Activity: Aug 9
ok so i looked online and i found somthing that shocked mebecause it was called suggle party http://www.cuddleparty.com/faq/paying 30 bucks for cuddling…Continue
Started by Ben the "Thunder-Otter". Last reply by Eleia Meridae Lam Sep 17, 2013.
whats the differnce,personal thought maybe suggling= sex idkContinue
Started by Ben the "Thunder-Otter". Last reply by Laura Elizabeth Campbell Oct 12, 2012.
Which do you prefer? ... I personally like being the little one. Continue
Started by Mynda. Last reply by Ben the "Thunder-Otter" Oct 12, 2012.
Here's one: Can cuddling between people be fully platonic, that is, friendly and non-shmexy? If so, how do you feel about your significant (real or hypothetical) other snuggling with friends? Is it…Continue
Tags: sexy, friends, platonic, snuggling, cuddling
Started by Peter Medeiros. Last reply by son-I-of-M-al Jul 17, 2012.
© 2015 Created by Hank Green. Powered by


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Cymbals Eat Guitars Share "Warning" Video, Announce Why There Are Mountains Reissue
By Zoe Camp on November 3, 2014 at 11:00 a.m. EST
Cymbals Eat Guitars have shared a clip for "Warning", taken from their recent album LOSE. Directed by Matthew Reed, the video features British upstarts Crosshair performing the song in place of the New York band. Check it out below.
Cymbals Eat Guitars Share "Warning"
By Evan Minsker on July 29, 2014 at 11:06 a.m. EDT
Cymbals Eat Guitars: "Warning" (via SoundCloud)
Cymbals Eat Guitars have a new LP called LOSE out on August 26 via Barsuk. (UPDATE: It will be released August 25 on Tough Love in the UK.) They already shared album opener "Jackson" as well as "Chambers", and today, they let go of another one called "Warning". They've also announced a North American tour alongside Bob Mould.
Cymbals Eat Guitars Announce New Album LOSE, Share "Jackson"
By Evan Minsker on May 13, 2014 at 10:50 a.m. EDT
Cymbals Eat Guitars: "Jackson" (via SoundCloud)
New York indie rockers Cymbals Eat Guitars last surfaced with 2011's Lenses Alien. On August 26, they're back with a new LP called LOSE, which is out via Barsuk. That up there is the album's opening track, "Jackson".
Hear New Male Bonding, Cymbals Eat Guitars LPs
By Larry Fitzmaurice on August 23, 2011 at 3:55 p.m. EDT
Endless Now, the new album from UK pop-punk wreckers Male Bonding, is out August 30 in the U.S. and August 29 in the UK on Sub Pop. Right now, the entire thing is streaming at Punknews.org.
There's a few other albums available for streaming, too; we've listed them below.
Cymbals Eat Guitars Share New Track, Tour
By Tom Breihan on July 11, 2011 at 2:25 p.m. EDT
New York/New Jersey indie revivalists Cymbals Eat Guitars will release Lenses Alien, their sophomore album on August 30 in the U.S. via Barsuk, moved up from September 13. (It's out September 12 in the UK via Memphis Industries.)
Down below, enter an email address into the widget to get a free MP3 of the album's opening track, the intimidatingly titled "Rifle Eyesight (Proper Name)".
Soon after the album lands, the band will head out on a North American tour, with Hooray for Earth opening. We've got their dates below as well.
New Release: Cymbals Eat Guitars: Lenses Alien
By Larry Fitzmaurice on June 6, 2011 at 4:35 p.m. EDT
Artists: Cymbals Eat Guitars
Album: Lenses Alien
Release Date: September 13 (UK) / September 14 (U.S.)
Label: Barsuk (U.S.) / Memphis Industries (UK)
Cymbals Eat Guitars Sign to Barsuk
By Larry Fitzmaurice on March 4, 2011 at 2:20 p.m. EST
It's been a little more than a minute since New York indie rockers Cymbals Eat Guitars have made a peep; now, that minute's up. The band has signed to Barsuk, and the label will release their follow-up to 2009's BNM'd debut Why There Are Mountains this fall. Cymbals Eat Guitars will record the album with producer John Agnello (Sonic Youth, Dinosaur Jr., Kurt Vile) manning the boards.
Thurston Moore, Cymbals Eat Guitars, Blitzen Trapper Added to Guided by Voices Tribute Album
By Ryan Dombal on October 21, 2010 at 4:35 p.m. EDT
Along with a previously announced cover from the Flaming Lips, artists lined up to contribute their takes on Guided by Voices tracks for an upcoming tribute LP include: Cymbals Eat Guitars, La Sera (aka Kickball Katy from Vivian Girls), Blitzen Trapper, the Clean's David Kilgour, the Breeders' Kelley Deal with Buffalo Killers, Elf Power, Of Montreal's James Husband, Drive-By Truckers' Jason Isbell, and Thurston Moore, whose previously released version of "Stabbing a Star" will make a reprisal.
The news comes courtesy of Indy Week (via Twenty Four Bit), which adds that the album and a bonus digital EP with GBV covers from smaller bands is due out on No More Fake Labels early next year. There are still a few artists yet to be announced; an incomplete tracklist can be seen after the jump:
Bear in Heaven and Cymbals Eat Guitars to Tour Together
By Tom Breihan on December 9, 2009 at 11:00 a.m. EST
Bear in Heaven photo by Rez Avissar
Brooklyn psychedelic synth-rockers Bear in Heaven and Staten Island trad-indie upstarts Cymbals Eat Guitars have both released BNM'ed albums over the past 12 months. And come March, the bands will hit the road together, hitting clubs across North America on a pretty extensive tour.
Before that joint tour can begin, though, they've both got a few things to take care of. This week, Cymbals Eat Guitars will play a few dates at Spain's Primavera Club Festival, and Bear in Heaven will play a few U.S. dates in January. We've got itineraries for both bands below.
Cymbals Eat Guitars Get New Bassist
By Tom Breihan on October 27, 2009 at 2:50 p.m. EDT
Photo by Rez Avissar
If fresh-faced Staten Island indie formalist bashers Cymbals Eat Guitars looked a little different in this CMJ photo, your eyes weren't playing tricks on you. The band's MySpace page lists a new bassist, a fellow named Matthew Whipple. He replaces Neil Berenholz, who, according to CEG's publicist, left the band amicably because he didn't like touring.
In other CEG news, they'll tour Europe this fall, playing dates with the likes of the Flaming Lips and the Dodos. Dates below.
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Page 1
Increased Exposure of
on the Surface of Tumor
Vascular Endothelium1,2
Jason H. Stafford and Philip E. Thorpe
Department of Pharmacology and Simmons Comprehensive
Cancer Center, University of Texas Southwestern Medical
Center, Dallas, TX, USA
We have previously shown that oxidative stress within the tumor microenvironment causes phosphatidylserine
(PS) to redistribute from the inner to the outer membrane leaflet of the endothelial cells (EC) creating a highly specific
marker for the tumor vasculature. Because the distribution of phosphatidylethanolamine (PE) and PS within the
membrane is coregulated, we reasoned that PE would also be localized in the outer membrane leaflet of tumor
EC. To demonstrate this, the PE-binding peptide duramycin was biotinylated and used to determine the distribu-
tion of PE on EC in vitro and in vivo. Exposure of cultured EC to hypoxia, acidity, reactive oxygen species, or irra-
diation resulted in the formation of membrane blebs that were intensely PE-positive. When biotinylated duramycin
was intravenously injected into tumor-bearing mice, it preferentially localized to the luminal surface of the vascular
endothelium. Depending on tumor type, 13% to 56% of the tumor vessels stained positive for PE. PE-positive ves-
sels were observed in and around hypoxic regions of the tumor. With the exception of intertubular vessels of the
kidney, normal vessels remained unstained. To test the potential of PE as a biomarker for imaging, duramycin was
conjugated to the near-infrared fluorophore 800CW and used for optical imaging of RM-9 prostate carcinomas. The
near-infrared probe was easily detected within tumors in live animals. These results show that PE, like PS, becomes
exposed on tumor vascular endothelium of multiple types of tumors and holds promise as a biomarker for nonin-
vasive imaging and drug targeting.
Neoplasia (2011) 13, 299–308
In normal cells, the aminophospholipids phosphatidylserine (PS) and
phosphatidylethanolamine (PE) are asymmetrically distributed across
the plasma membrane with essentially all the PS and the majority of
the PE localized in the cell's inner membrane leaflet [1,2]. This mem-
brane lipid asymmetry is maintained by a group of P-type ATPases
known as aminophospholipid translocases (APTLs) that catalyze the
active transport of PS and PE from the external to the internal leaflet
of the plasma membrane [3]. Unlike normal cells, apoptotic cells and
tumor cells lose their capacity to maintain PS asymmetry resulting in
the appearance of the lipid in the cells' outer membrane leaflet. The
expression of PS at the cell surface inhibits immune responsiveness
and, in the case of apoptotic cells, also serves as a recognition ligand
and binding site for phagocytes [4,5]. PE has also been shown to be
exposed on apoptotic cells, but it has not been associated with a spe-
cific function [6].
Increases in intracellular [Ca2+] as a result of transcriptional acti-
vation or exposure to environmental stress can also cause loss of
membrane asymmetry. Influx of exogenous Ca2+or Ca2+released
from intracellular stores inhibits APTLs and, at the same time, acti-
vates ATP-binding cassette transporters and phospholipid scram-
blases that randomize all membrane phospholipids between leaflets
Address all correspondence to: Dr. Philip E. Thorpe, University of Texas Southwestern
Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8594.
E-mail: email@example.com
1This research was supported in part by a sponsored research agreement with Peregrine
Pharmaceuticals, Inc. (Tustin, CA) and funding from the Gillson Longenbaugh Foun-
dation (TX). Imaging was facilitated by the Southwestern Small Animal Imaging Re-
source (SW-SAIR), which is supported in part by the NCI U24 CA126608, the
Harold C. Simmons Cancer Center, which is supported in part by an NCI Cancer
Center Support Grant, CA142543-01, and the Department of Radiology.
2This article refers to supplementary materials, which are designated by Figures W1 to
W4 and are available online at www.neoplasia.com.
Received 20 September 2010; Revised 12 January 2011; Accepted 17 January 2011
Copyright © 2011 Neoplasia Press, Inc. All rights reserved 1522-8002/11/$25.00
DOI 10.1593/neo.101366
Volume 13 Number 4April 2011pp. 299–308
Page 2
resulting in a complete loss in plasma membrane lipid asymmetry
[7,8]. Environmental stress also activates sphingomyelinases that
cleave sphingomyelin (SM) to ceramide [9,10]. Ceramide destabilizes
the bilayer, activates proapoptotic signaling pathways, and promotes
membrane blebbing [11,12]. Thus, cellular stress and activation can
promote the exposure of aminophospholipids on the cell surface
through multiple pathways. Indeed, unlike quiescent normal endo-
thelium, there is significant environmental stress imposed on the tu-
mor endothelium by acidity, reactive oxygen species (ROS), and
transient hypoxia, which results in the redistribution of PS to the cell
surface [13]. Consequently, PS becomes exposed on vascular endo-
thelium of all tumor types so far examined [14,15]. Because both PS
and PE are coregulated by the same transporters, [2] the expression
of cell surface PS on tumor EC raises the possibility that PE is also
expressed on the surface of tumor blood vessels.
Duramycin (MWt = 2013 Da) is a highly specific PE-binding
peptide produced by the bacteria Streptoverticillium cinnamoneus.
Duramycin binds PE at a 1:1 molar ratio with a Kdof 4 to 6 nM,
an unusually high affinity for a small, ligand-binding peptide [16].
Duramycin is the smallest polypeptide known to have a defined
three-dimensional binding pocket and recognizes ethanolamine phos-
pholipids with exclusive specificity [16] by fitting over the etha-
nolamine head group like a glove [17]. The hydrophobic binding
pocket is stabilized by three internal thioether linkages that make
the peptide resistant to heat and proteolytic degradation [18]. Pharma-
cokinetic studies in rats have shown that duramycin is rapidly cleared
from the blood stream with a serum half-life of less than 4 minutes
[19].99mTc-labeled duramycin binds to PE exposed on apoptotic
and necrotic cells and has been used successfully for the in vivo imag-
ing of acute myocardial infarction [19].
In this report, we used duramycin to show that PE becomes spe-
cifically exposed on the surface of tumor EC and that treatment of
cultivated EC with known tumor-associated stresses causes the for-
mation of PE-positive blebs on the cell membrane. In vivo studies
revealed that labeled duramycin specifically localized to the vascular
endothelium in multiple tumor types. Duramycin was also effective
at imaging subcutaneous tumors. Taken together, these findings in-
dicate that externalized PE may be a general marker of tumor vas-
culature and suggest that duramycin possesses the specificity and
pharmacokinetic properties to make it an effective agent for specifi-
cally targeting the tumor vasculature with imaging agents and/or
therapeutic drugs.
Materials and Methods
Duramycin from S. cinnamoneus, bovine serum albumin (BSA),
o-phenylenediamine dihydrochloride (ODP), and vascular endothe-
lial growth factor (VEGF) were purchased from Sigma (St Louis,
MO). Sulfo-NHC-LC biotin was obtained from Pierce (Rockford,
IL). IRDye 800CW NHS Ester was obtained from LI-COR Bio-
sciences (Lincoln, NE). Dulbecco modified Eagle tissue culture me-
dium, Dulbecco phosphate-buffered saline (PBS) containing Ca2+
and Mg2+, glutamine, and fetal bovine serum (FBS) were obtained
from HyClone (Thermo Scientific, Logan, UT). Alexa Fluor 488–
conjugated streptavidin, Alexa Fluor 350–conjugated streptavidin, and
Prolong Gold mounting medium with 4′,6-diamidino-2-phenylindole
(DAPI) were obtained from Molecular Probes (Invitrogen, Carlsbad,
CA). Horseradish peroxidase–conjugated streptavidin and Cy3-
Laboratories (West Grove, PA). Immulon 1B 96-well microtiter plates
NC). PE, phosphatidylcholine (PC), PS, SM, phosphoinositol (PI),
phosphatidic acid (PA) and phosphatidylglycerol (PG) were obtained
from Avanti Polar Lipids (Alabaster, AL).
The PS-targeting antibody bavituximab is produced under serum-free
requires 1:1 addition of human β2-glycoprotein to bind PS. Rituxan is
a human monoclonal antibody that binds human CD20 and was
obtained from the UT Southwestern Pharmacy. Rat antimouse CD31
antibody was purchased from BD Biosciences (San Jose, CA). Goat
antihuman immunoglobulin G (IgG) conjugated to Cy2, goat antirat
IgG conjugated to Cy3, and biotinylated goat antirat IgG secondary
antibodies were obtained from Jackson Immunoresearch Laboratories
(West Grove, PA).
Synthesis of Duramycin Conjugates and Control Peptides
Duramycin was reacted through its free amino groups with an N-
hydroxysuccinimide (NHS) ester of a long-chain (adipic) derivative
of L-biotin at a molar ratio of 1:1.1. Briefly, NHS-biotin in dimethyl
sulfoxide was rapidly mixed with duramycin in PBS. The reaction
was allowed to proceed for 2 hours. Unreacted biotin was removed
by dialysis. The product corresponding to one molecule of duramycin
linked to one molecule of biotin was purified by high-performance
liquid chromatography. Mass spectrometry confirmed a molecular
mass of 2352 Da (Figure 1A). The duramycin–L-biotin conjugate
(DLB) was supplemented with an equal weight of unlabeled duramy-
cin for all assays, as its addition strengthened PE binding. The control
peptide linear duramycin (linDUR) was synthesized by Biosynthesis,
thioether-linked amino acids were substituted with alanines. linDUR
was biotinylated to produce the control peptide linear–duramycin-L-
biotin (linDLB). linDLB was also supplemented with an equal weight
of unlabeled duramycin for all assays.
Duramycin was reacted with the NHS ester of IRDye 800CWat a
1:1 molar ratio as described above. The product consisting of one
molecule of duramycin linked to one molecule of 800CW was pu-
rified by high-performance liquid chromatography. Mass spectrom-
etry confirmed a molecular mass of 2998 Da (Figure 1B). linDUR
reacted with IRDye 800CW produced the control peptide referred
to as 800CW-linDUR. Both 800CW-DUR and 800CW-linDUR
were supplemented with an equal weight of unlabeled duramycin
for all assays.
Adult bovine aortic endothelial (ABAE) cells were obtained form
Clonetics (Walkersville, MD). RM-1 mouse prostate carcinoma,
RM-9 mouse prostate carcinoma, 4T1 mouse breast carcinoma,
B16 mouse melanoma, and A549 human lung carcinoma cells were
obtained from American Type Cell Collection (Rockville, MD).
MDA-MB-231 human breast carcinoma cells were provided by
Dr Robert Kerbel (Sunnybrook Health Sciences Center, Toronto,
Ontario, Canada). All cells were maintained in Dulbecco modified
Phosphatidylethanolamine on Tumor EndotheliumStafford and ThorpeNeoplasia Vol. 13, No. 4, 2011
Page 3
Eagle medium supplemented with 10% FBS and 2 mM L-glutamine.
Cells were trypsinized with 0.25% trypsin and 2.1 mM EDTA
(Mediatech Inc, Manassas, VA).
Growth of Subcutaneously Implanted Tumors
For localization studies, 106RM-1, RM-9, or B16 cells were in-
jected into the right-hind flank of male C57BL/6 mice (UTSW
breeding core). A549 cells (5 × 106cells) were injected into the
right-hind flank of female athymic nu/nu mice (CharlesRiver, Fredrick,
MD). Tumors were allowed to grow to a volume of 0.7 to 1.0 cm3.
Orthotopic MDA-MB-231 and 4T1 Breast Carcinoma Models
Female nu/nu or severe combined immunodeficient mice were
purchased from Charles River. MDA-MB-231 or 4T1 cells (5 ×
106) suspended in 0.1 ml were implanted into the mammary fat
pad as described previously [20]. Briefly, mice were anesthetized,
and a 5-mm incision was made in the skin over the lateral thorax.
The mammary fat pad was exposed to ensure the correct site of im-
plantation, and tumor cells were injected with a 25-gauge needle.
The incision was closed with a wound clip that was removed 5 to
7 days later.
MMTV-PyMT Transgenic Mice
Mouse mammary tumor virus (MMTV) promoter–driven expres-
sion of polyoma middle T antigen (PyMT) results in mammary
gland–specific adenocarcinoma formation [21]. Female MMTV-
PyMT mice were obtained from the laboratory of Dr Rolf Brekken
at UT Southwestern Medical Center (Dallas, TX).
Antiphospholipid ELISAs
To test the binding of DLB and 800CW-DUR, phospholipids
were dissolved in n-hexane (10 μg/ml), and 50 μl of this solution
was added to wells of Immulon 1B or LUMITRAC 96-well plates.
The solvent was evaporated at room temperature, and the plates were
blocked for 1 hour with 5% FBS dissolved in PBS. DLB and
800CW-DUR were diluted in blocking buffer at an initial concen-
trations of 1 and 10 μg/ml, respectively, and twofold dilutions were
Figure 1. Lipid specificity of the PE binding probes DLB and 800CW-DUR. (A) Structure of duramycin-linked biotin (DLB) and ELISA
showing DLB binds specifically to PE. (B) Structure of duramycin conjugated to the near-infrared fluorophore IRDye 800CW (800CW-
DUR) and ELISA showing that 800CW-DUR also retains binding specificity for PE. The structures show conjugation through the pre-
ferred lysine, although conjugation can also occur at the N-terminus.
Neoplasia Vol. 13, No. 4, 2011Phosphatidylethanolamine on Tumor Endothelium Stafford and Thorpe
Page 4
performed in a separate 96-well plates (100 μl/well). Phospholipid-
transferred from dilution plates to Immulon 1B and LUMITRAC
plates, respectively. The plates were incubated for 1 hour at room tem-
perature and thenwashed.Bound 800CW-DURwas detectedusing an
Odyssey imaging system (LI-COR Biosciences, Lincoln, NE). Bound
DLB was detected using HRP-conjugated streptavidin (1:2000 in
blocking buffer) and ODP substrate. The optical density of ODP
was read at 490 nm using a microplate reader (BioTek Instruments,
Winooski, VT).
Hemolysis Assay
Fresh mouse blood was treated with heparin (15 IU/ml) and
centrifuged (300g for 5 minutes) to sediment the red cells. After
three washes, the red cells were resuspended in 10× the original vol-
ume of blood. Duramycin or DLB was serially twofold diluted in
PBS in 100-μl volumes in 96-well round-bottomed microplates.
The red cell suspension (100 μl/well) was added. The plates were
kept at room temperature for 1 hour. Supernatants were removed,
and their absorbance was measured at 575 nm in an ELISA reader.
Immunohistochemical Detection of Exposed PE on the Surface
of Cultured Endothelial Cells
ABAE cells were cultured in eight-well chamber slides (BD Falcon,
Bedford, MA) until approximately 80% confluent. To induce PE ex-
posure, cells were irradiated with 5 Gy 24 hours before staining. Un-
treated cells were used as a control. Cells were incubated with DLB
(0.5 μg/ml) dissolved in culture media. linDLB (0.5 μg/ml) was used
as a negative control. Bavituximab (1 μg/ml) was used as a positive
control for detection of PS. The cells were then washed with PBS and
fixed with 4% paraformaldehyde for 10 minutes. Excess aldehyde
groups were quenched with 50 mM ammonium chloride for 5 min-
utes. Biotinylated peptides were detected by incubating Alexa Fluor
488– or Cy3-conjugated streptavidin (1:1000 in 1% BSA) for 30 min-
utes. Cell membranes were permeablized with 0.5% Triton X-100
(5 minutes), and cytoskeletons were stained with Texas Red–labeled
phalloidin (1:200 in 1% BSA; 30 minutes). Cell nuclei were counter-
stained with DAPI.
Effect of ROS, Hypoxia, pH, and VEGF on PE Exposure in
Cultured EC
For all treatments, ABAE cells were cultured in 75-cm2flasks
(Corning, Inc, Lowell, MA) until approximately 80% confluent.
To mimic ROS in tumors, cells were treated with 10 μM H2O2in
serum-free medium for 1 hour. To study the effect of hypoxia, flasks
of cells were placed in a humidified normoxic atmosphere (21% O2,
5% CO2) for 48 hours before being transferred to a humidified hyp-
oxic atmosphere (1% O2, 5% CO2, 94% N2) in a sealed chamber
(BioSpherix, Lacona, NY). The cells were incubated in the hypoxic
chamber at 37°C for 24 hours and were then returned to a normoxic
environment for 4 hours at 37°C. To study the effect of acidity, cells
were incubated for 24 hours in bicarbonate-free medium adjusted to
pH 5.8 with HCl at 37°C and in the absence of CO2. Untreated cells
from an identical passage were used as controls. After all treatments,
cells were trypsinized for 1 minute, washed, and resuspended in ice-
cold FACS buffer (PBS with 10% FBS and 0.02% NaN3). To
detect externalized PE, cells were incubated with DLB (0.5 μg/ml)
for 1 hour. linDLB (0.5 μg/ml) was used as a negative control.
Bavituximab (20 μg/ml) was used to detect exposed PS, and rituxan
(20 μg/ml) was used as a nonbinding control for bavituximab. Cells
were washed, and bound peptides were detected with Alexa Fluor
488–conjugated streptavidin (1:3000 in FACS buffer), and bound
antibodies were detected with goat antihuman IgG-Cy2 (1:3000).
Apoptotic cells were identified with propidium iodide. The cells were
analyzed with a FACScan flow cytometer (BD Biosciences).
Localization of Duramycin Peptides in Tumor-Bearing Mice
In Vivo
To detect PE on the surface of EC, DLB (100 μg) was injected
intravenously into tumor-bearing mice. Bavituximab (150 μg) and
linDLB (100 μg) were used as positive and negative controls, respec-
tively. The mice were killed after 60 minutes and perfused with hep-
arinized saline as described previously [15,22]. The tumor and major
organs were removed and snap-frozen, and 10-μm cryosections were
cut. Sections were incubated overnight with rat antimouse CD31 anti-
body (1:200 in 1% BSA). Goat antirat IgG-Cy3 was used to detect the
CD31 antibody. DLB was detected with Alexa Fluor 488–conjugated
streptavidin. Bavituximab was detected with goat antihuman IgG-Cy2.
Cell nuclei were counterstained with DAPI. PE-positive vessels were
classified as DLB+, CD31+-costained structures having vascular endo-
thelial cell morphology.
Detection of Hypoxia in PE-Positive Tumors
One hundred micrograms of DLB was injected intravenously into
male C57BL/6 mice bearing RM-9 tumors. Immediately afterward,
2 mg of pimonidazole HCl (Hypoxyprobe-1 kit, Burlington, MA)
was injected intraperitoneally. After 1 hour, tumors were harvested
and sections were prepared as described previously [22]. Sections were
incubated overnight with rat antimouse CD31 IgG antibody (1:200)
and fluorescein isothiocyanate–labeled antibody against the pimonida-
zole adduct (Hypoxyprobe-1 kit) (1:50) in 1% BSA. The following
day, sections were stained with saturating amounts of Cy3-conjugated
streptavidin (1:500) to detect DLB. After washing, the sections were
incubated with biotinylated goat antirat IgG (1:500) followed with
Alexa Fluor 350–conjugated streptavidin (1:500) to detect the CD31
antibody. Immunohistochemical staining for pimonidazole adduct
formation was also used to compare levels of hypoxia in similar-sized
(1-cm-diameter) RM-9 tumors and 4T1 tumors. For each tumor type,
multiple fluorescent imageswerecapturedat low magnification (100×),
and hypoxia staining was quantified using ImageJ software.
Imaging of Tumors with 800CW-DUR
In vivo near-infrared fluorescence imaging was performed using a
Xenogen IVIS Lumina imaging system (Xenogen, Alameda, CA).
800CW-DUR (50 μg) was injected into a tail vein in male mice
bearing RM-9 tumors. 800CW-linDUR (50 μg) was used as a control.
Twenty-four hours after injection, mice were anesthetized with 2% iso-
flurane (Halocarbon, North Augusta, SC), and images were obtained.
tected using the NIR filter set (excitation between 605 and 780 nm
and emission between 810 and 885 nm).
Modification of Duramycin to Create the PE-Binding Probes
DLB and 800CW-DUR
DLB was produced by reacting duramycin with the NHS ester of
L-biotin (Figure 1A). Lipid binding was assessed by ELISA. Figure 1A
Phosphatidylethanolamine on Tumor EndotheliumStafford and ThorpeNeoplasia Vol. 13, No. 4, 2011
Page 5
shows that DLB binding was specific for PE with maximum binding
occurring at ∼0.5 μg/ml (0.2 μM). Although some binding to PC
was observed at the higher concentrations, binding to PS, PI, PA,
and SM was undetectable. 800CW-DUR for noninvasive in vivo
imaging was produced by reacting duramycin with the NHS ester
of IRDye 800CW (Figure 1B). Similar to DLB, the IR probe
(800CW-DUR) demonstrated specificity for PE up to ∼5 μg/ml
(Figure 4B). Maximal binding occurred at ∼5 μg/ml (1.7 μM). Thus,
modification of duramycin by conjugation to L-biotin did not change
its affinity or specificity of binding to PE. DLB lysed 50% of murine
red cells at 80 μM compared with 20 μM for duramycin itself,
showing that biotinylation reduced the hemolytic activity of duramy-
cin by fourfold.
DLB Binds to PE on the Surface of Irradiated EC
We have previously shown that binding of fluorescent liposomes
coated with duramycin or bavituximab to ABAE cells is enhanced by
x-irradiation [2]. Here, we used biotinylated duramycin (DLB) with
FACS analysis and immunofluorescence staining to detect PE on the
surface of nonirradiated and irradiated ABAE cells. Figure 2A shows
that DLB bound to 37% of control ABAE cells. Irradiation increased
DLB binding to 93% of the cells and increased their median fluores-
cence intensity by fourfold to fivefold. Consistent with previous data
showing that irradiation induces PS externalization, immunofluores-
cence analysis of the cells 24 hours after 5-Gy irradiation showed that
both DLB (PE) and bavituximab (PS) bound to membrane blebs
(Figure 2B).
Figure 2. DLB binds PE exposed on cultured EC. DLB was used to detect PE on the surface of irradiated ABAE cells. (A) FACS analysis of
DLB-labeled ABAE cells that were untreated (upper panels) or had been irradiated with 5 Gy 24 hours earlier (lower panels). (B) Cells
were incubated with DLB or bavituximab, and binding was detected with streptavidin–Alexa Fluor 488 and Cy2–goat antihuman Ig,
respectively. LinDLB was used as a negative control for DLB. The cells were counterstained with Texas Red–labeled phalloidin.
Neoplasia Vol. 13, No. 4, 2011Phosphatidylethanolamine on Tumor EndotheliumStafford and Thorpe


text:
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Gardens West is your one-stop solution to bring all of your outdoor living dreams to life! We do it all- from design to installation to maintenance. From swimming pools,outdoor kitchens,patios,decks and overheads to fences,retaining walls,planting,irrigation and lightingwe plan and take loving care of all the details!
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Little Wilson Cottage
Life in the slow lane - lakefront, swimming, boating, family fun!
231 North Hill Rd Buckfield, ME US 04220
Seasonal rate: $850 a week (June 20-Sept 7). See our website for off-season rates and more photos: http://www.ourcottageinmaine.com/
(207) 740-4855
Payments Accepted:
Deck with table and grill
This traditional Maine cottage has 150 feet of private lake frontage on Little Wilson Pond in Turner. Quiet and serene, it's a world away from the hustle-bustle of everyday life, yet close to Lewiston/Auburn amenities and only 50 miles from Portland. Woods on both sides of the property ensure privacy. The sundeck is a perfect place to dine, read, or just lie back and relax. Swimmers can jump into the water from the dock or swim float. Rowboat, 4 kayaks, fire ring, hammock. The cottage has a fully equipped kitchen, full bathroom and oil heat. First-floor bedroom has a double bed; the loft has two double beds and one single. Maximum occupancy is six.
Fall Special! Week At Lakeside Maine Cottage For $700! Sleeps 6.
Enjoy all the pleasures of life in the slow lane at our traditional Maine cottage on the shore of Little Wilson Pond in Turner. Gorgeous fall...
Columbus Day Lakeside Weekend Retreat
Family fun, romantic weekend, or friends' get-together. 3 nights for $375; midweek and full week stays also available - please inquire. Offer...


text:
Wastech is a Canadian company based in Coquitlam, British Columbia. With more than 30 years of experience, Wastech is a strong partner for corporations, goverMore
$5 mil. - $10 mil.in Revenue
20 - 50EmployeesContact people at this company
wastesolid reputationMore
Waste Treatment, Environmental Services & RecyclingEnergy, Utilities & Waste TreatmentMore
1200 United BoulevardCoquitlamBritish ColumbiaV3K 6T4Canadaview map
(800) 667-4321(604) 521-0763Fax
Pro2015_Iteration9_NoTests.148[02] SEIDXWK-41


text:
Originally posted on Fox Sports Wisconsin | Last updated 2/3/13
Today is the eighth day of FOX Sports Wisconsin Packers writer Paul Imig's offseason evaluations of every player on Green Bay's roster. Click here for all of Paul's previous evaluations and come back every day through mid-March for Paul's in-depth film and statistical analysis. Coming up soon: Tuesday, Feb. 5: TE Tom Crabtree Wednesday, Feb. 6: K Mason Crosby Thursday, Feb. 7: DL Mike Daniels Friday, Feb. 8: C Evan Dietrich-Smith RANDALL COBB, WIDE RECEIVER, KICK PUNT RETURNER Season stats: 17 games (15 regular season, two postseason), team-high 954 receiving yards, team-high 80 catches, team-high 104 targets, eight receiving touchdowns, team-worst 11 dropped passes, team-best 16 forced missed tackles; 25.37-yard kick return average, zero touchdowns; 9.42-yard punt return average, one touchdown Best game: Week 7 win at St. Louis (eight targets, eight catches, 89 yards, two touchdowns; one rush, 19 yards; 2.5 PFF offensive rating; one kick return, 23 yards; one punt return, 15 y...
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text:
Origins Never a dull moment skin brightening face cleanser 150ml
Item No.1236309093
Item No.1236309093
Now send skin drearies down the drain. With each passing year skin's ability to do its own daily slough of surface stuff slows down. Skin can look mighty drab and dreary. So we blended extract of crushed Papaya, with creamy cleansers to create a lush-lathering, fruit-smoothie of a face wash. Simply swirl it over splashed-moist skin and watch how swiftly it disposes of dingy, dried up cells, makeup, dirt and debris to totally banish bleakness. Skin emerges with a fresh, radiant sheen. Feels sleek and silky-smooth, never stripped-dry. Melts makeup, dirt and debris to banish bleakness. For oily skin.
£12.33 per 100ml
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Subject to exceptions, Debenhams is happy to exchange or refund your purchase within 28 days of delivery. Please check here for more details on our returns policy and exceptions.


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InfoSeek - the advanced search tool for targeted infomation, is designed to extract customized information (such as e-mail addresses, phone/fax numbers, Zip codes etc.) from web-pages on the Internet and from files on local disks.
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text:
We eat here about once a month and love it every time. The food always comes out quick and hot. The staff have always been very polite.
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text: The New Jersey Devils' Dainus Zubrus, center, celebrates his goal with teammates during the third period (AP Photo/Tom Mihalek) [ Devils win their season opener, beat Flyers 6-4 By Associated Press October 10, 2014 PHILADELPHIA (AP) -- Dainus Zubrus scored the go-ahead goal in the third period and Michael Cammalleri had two goals, leading the New Jersey Devils to a season-opening 6-4 win over the Philadelphia Flyers on Thursday night. Read More|Comment Category: News, Sports Tags: New Jersey Devils, Philadelphia Flyers Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
New York Times quotes Rebecca HendrickMay 6, 2013
The New York Times quotes Rebecca Hendrick, associate professor of public administration, in a story about a new outlet mall under construction in
Rosemont. Hendrick describes Rosemont's role in serving the nearby O'Hare Airport with retail, entertainment and conference facilities. http://nyti.ms/ZNGvYW
Alumni Testimonials
Jeanne Chiu
"Because of my interest in improving the human condition through public service, I chose to enter the MPA program at UIC. Chicago, rich in history, diversity, and politics, is the perfect place to learn about all aspects of public administration. For my Capstone team project, I was provided the opportunity to collaborate with a nonprofit organization on the West Side of Chicago to develop a training and professional development curriculum. As Public Service Chair of PASA, I have volunteered alongside many of my colleagues in different service projects in the Chicagoland area. I like how this MPA program provides opportunities for students to interact with each other in the classroom and outside the classroom environment. It is a flexible program that enables students working full-time the ability to take classes at night. I would highly recommend the MPA program at UIC to prospective students."


text:
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text:
3D printing: Dubai leads the way
Kippreport explores the technology that's currently trending at GitexOctober 7, 2015 3:08
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MIDEAST STOCKS-Markets to rise on stronger global environment
Abu Dhabi's ADWEA in talks with banks for $350 mln project bond
Emirates hints at no Dubai Airshow orders, pushes decision on A350/787 to next year
UAE minister says plans to boost oil output capacity on track
MIDEAST STOCKS-Saudi, Egypt markets barely move in early trade
Qatar Q2 GDP growth accelerates to 4.8 pct year/year
UAE says reforms will better protect foreign workers
United Arab Bank secures $125 mln three-year loan
MIDEAST STOCKS-Saudi hit by weak oil, commodities; Egypt down modestly
MIDEAST STOCKS-UAE markets narrowly mixed in thin, early trade
Abu Dhabi sovereign wealth fund publishes first annual review, including a breakdown of its portfolio by class – but doesn't disclose the value of its assets.
March 15, 2010 6:40 by kippreport
Abu Dhabi's sovereign wealth fund, which has been termed 'secretive' over its multi-billion dollar investment strategy, today published its first annual review, providing an breakdown of its holdings by asset class and region – although it stopped short of disclosing the total value of its portfolio.
The Abu Dhabi Investment Authority (ADIA), which has been rumored to hold investments worth around $600 billion, said in the review that it has invested as much as 45 percent of its assets in developed markets.
ADIA also disclosed that it has 10-20 percent of its assets in government bonds, while as much as 10 percent is invested in real estate, credit and alternative assets such as hedge funds. ADIA has seen a 20-year annual rate of return of 6.5 percent, and a 30-year rate of return of 8 percent as of the end of last year, the report said.
The publication of the review coincided with the relaunch of the ADIA website.
Egypt shares down on concerns over Mubarak's health
March 15 2010
Further Dubai aid 'won't be necessary'
March 15 2010


text:
Flow Battery Gets Connected to California Grid
EnerVault's grid-scale, iron-chromium redox flow battery has been activated in Turlock, Calif. Interconnected to the distribution grid, EnerVault Turlock is co-located with a dual-axis tracking solar photovoltaic system in an almond orchard in California's Central Valley.
EnerVault designed and manufactured the long-duration, grid-scale energy storage system in Silicon Valley with a combination of private funding and research and development grants from the DOE and the Energy Commission.
EnerVault's technology stores energy in tanks of electrolytes. "The fluid is then pumped through the battery's cells when power is needed," according to SFGate.
Enervault's flow batteries blend iron and chromium into the water inside its tanks – materials that are safe as well as cheap, says the company.
The California Public Utility Commission is working with the state's utilities to incorporate a wide range of energy storage capabilities into the grid.
- How to Thrive in Today's EHS Landscape
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- Migration to Mobile: The Evolution of EHS Management Tools
- Verdantix Green Quadrant for EHS Software
- Mobility from the Plant Floor to the Store Door: Improve Safety, Accuracy and Productivity


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What do you consider a strong work-life balance? What types of benefits truly help alleviate stress from work? In preparation for SHRM15, we've been thinking a lot about the state of human resources and asking ourselves important questions like these. With all the buzz surrounding unlimited vacation lately, we decided to flex our creative muscles…
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New Legal Guide: Human Resources 101
In our "Simple Ways to Make Your Employees Happy" post, we list HR education as one of the two solutions in making (and keeping) your employees happy. So if you're headed to Vegas for SHRM15 next week, then great work! You're already taking the right steps as a HR professional. If you're in need of a…
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Just two weeks from now, industry leaders and human resources professionals will flock to the Party Capital of the World. The reason? For the SHRM Annual Conference & Exposition, of course! The conference, held at the Vegas Convention Center, is still weeks away so in the meantime (or if you're unable to attend this year),…
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Taxes, (Un)Explained: The Best Things in Life Are Tax-Free
If there's one thing even most Republicans and Democrats agree on, it's that the tax system should be "fair," if for no other reason than people then feel better about paying their due, and theoretically, at least, cheat less. Unfortunately that taxes should be "fair" is one of those inch-deep accords, since as soon as…
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Simple Ways to Make Your Employees Happy
Communication is key to any relationship, even ones at work. One of the simplest ways to bridge the gap in communication between employee and employer is through your very own human resources (HR) department. A 2013 survey titled Human Capital Management's Employee Disconnect: A Global Snapshot, conducted by ADP Research Institute, revealed an extreme disparity…
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Lawyers vs. Accountants: Round 1
It seems you can't go a day without reading about how law school enrollment is plummeting, big law firms are imploding, lawyers are flaming out faster than 4th of July fireworks, and the profession, once regarded as something to aspire to, now ranks, in the public's imagination, somewhere between human bug-eater and professional sociopath in…
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Infographic: The 2015 State of Small & Medium Businesses
On January 20th, President Barack Obama delivered the annual State of the Union address to a joint session in Congress as well as to millions of Americans gathered around the television—all in anticipation to hear our country's top concerns, national priorities, and future plans. Taking note from the White House itself, twice a year, we…
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It's that time of year again! You've reviewed last year's performance and now, it's time to use all that you've learned, move forward, and implement all those big plans you have lined up for 2015. But as important as tweeting your daily deals can be, there are other necessary steps to take before you go…
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Take a look around your office. There's a high probability that you're working with people of every age range. With advanced technology and medical breakthroughs, people are living longer, which means retirement is being delayed more and more every year. Consequently, people are working until a later age to save up for a longer and…
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Joe Papa, Perrigo chairman & CEO, talks about Mylan's hostile bid for Perrigo and why he wants shareholders to reject the offer.» Read More
April 17- Teva Pharmaceuticals Industries is considering a bid for Mylan NV, Bloomberg reported, citing people familiar with the matter. Teva has not made a formal approach, Bloomberg reported. Generic drugmaker Mylan offered to buy Perrigo Co Plc for about $29 billion in cash and stock in early April.
The "Halftime Report" traders give their trades for the second half.
Perrigo is set to close a huge deal for Omega Pharmaceuticals. Perrigo CEO Joseph Papa, discusses the benefits of the deal, and the company's move to Ireland.
Some of the names on the move ahead of the open.
We're moving into a time of year that's been difficult for bulls, historically. However, if the market does sell off, Cramer won't cry.
The stock market might be making new all-time highs on almost a daily basis, but that doesn't mean there isn't bargain to be had.
U.S. generic drug rules have been manipulated by brand-name drug companies to keep cheaper competition off the market, a report says.
U.S. health officials finalized guidelines for infant formula makers that aim to ensure products meet certain quality controls to keep them safe.
Some of Wednesday's midday movers:
There are some solid reasons why Pfizer's reported $101 billion bid for AstraZeneca makes some sense, analysts said.
The FTC has sued pharmaceutical companies $1 billion for delaying the sale of cheaper medicines after patents on brand-name drugs may have expired.
A couple of stocks stand to gain over the next two weeks, Paul Hickey of Bespoke Investment Group says.
Events in Ukraine appear to be improving, but it may only be a matter of time before they take another turn for the worse. Are you prepared?
In his book "Get Rich Carefully," CNBC's "Mad Money" host explains how spotting long-term megatrends can help investors surf the wave of profitability.
Cramer believes there's always opportunity in the market. You simply have to know where to look.
Perrigo CEO Joseph Papa provides insight on the current flu season, and how it plans on getting its name better known.
Perrigo CEO Joseph Papa discusses how its new headquarters in Ireland will impact its tax structure, and whether the company will add a dividend.
Jim Cramer has been a fan of this company for quite some time. But a good stock always needs new catalysts.
Investing is a bit like an Ellery Queen mystery. If you can follow the clues you should find what you're seeking - upside.
More large American corporations are reducing their tax bill by buying a foreign company and effectively renouncing their United States citizenship.


text: SDN Members don't see this ad. (About Ads) Just got home from the testing center! This was my first and only time taking the DAT. I'm very happy with how it all turned out! PAT 20 QR 20 RC 25 BIO 19 GC 18 OC 26 TS 20 AA 22 PAT: I thought I'd score a little higher than 20 on this, but I'm definitely happy with this score. To study, I mainly used Crack DAT PAT. It was pretty similar to the actual test. I think angle ranking was a lot easier on the actual DAT. Top Front End was a lot easier on the DAT than they were on Achiever. QR: To study for this I used Destroyer and Achiever. The problems were very approachable. The calculator worked fine (I'd heard it was slow and laggy for a lot of people). I didn't get any questions that were insanely difficult. Destroyer problems were very representative of the actual problems. Achiever was harder. Most of the time I couldn't finish the QR section on Achiever. RC: I didn't study at all for this one. I'd taken a couple practice tests with Achiever and Crack DAT. The passages were not too incredibly boring. They were much more pleasant to read than the ones in the practice tests. BIO: I studied for this with Destroyer, Achiever, Kaplan Blue Book and Barron's DAT book. Achiever and Destroyer questions are WAY harder than the actual DAT questions. The questions didn't seem over my head. I didn't get any development questions, which I studied pretty hard. GC: I knew this would be my lowest scoring section. I studied for it by using Chad's Video's, Destroyer, and Achiever. Chad is an absolute gem. Didn't get any delta H/multiple equation calculations at all. OC: This score blew my mind. When I took Organic Chemistry, I got a B and two C+s. I failed the ACS. I studied for this section using Chad's Video's, Destroyer, and Achiever. I was consistently getting 17's in this section on Achiever. Chad is what saved me. I just remembered the reactions he highlighted, and it got me a great score. I'm so flippin' happy to get this done! I've been studying for the last three months while taking 19 credits at school. I was shaking and almost crying when my score popped up on the screen! Made the last few months totally worth it!