text:
RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
ABSTRACT Tumours with mutant BRAF are dependent on the RAF-MEK-ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells with mutant BRAF, but unexpectedly enhance signalling in cells with wild-type BRAF. Here we demonstrate the mechanistic basis for these findings. We used chemical genetic methods to show that drug-mediated transactivation of RAF dimers is responsible for paradoxical activation of the enzyme by inhibitors. Induction of ERK signalling requires direct binding of the drug to the ATP-binding site of one kinase of the dimer and is dependent on RAS activity. Drug binding to one member of RAF homodimers (CRAF-CRAF) or heterodimers (CRAF-BRAF) inhibits one protomer, but results in transactivation of the drug-free protomer. In BRAF(V600E) tumours, RAS is not activated, thus transactivation is minimal and ERK signalling is inhibited in cells exposed to RAF inhibitors. These results indicate that RAF inhibitors will be effective in tumours in which BRAF is mutated. Furthermore, because RAF inhibitors do not inhibit ERK signalling in other cells, the model predicts that they would have a higher therapeutic index and greater antitumour activity than mitogen-activated protein kinase (MEK) inhibitors, but could also cause toxicity due to MEK/ERK activation. These predictions have been borne out in a recent clinical trial of the RAF inhibitor PLX4032 (refs 4, 5). The model indicates that promotion of RAF dimerization by elevation of wild-type RAF expression or RAS activity could lead to drug resistance in mutant BRAF tumours. In agreement with this prediction, RAF inhibitors do not inhibit ERK signalling in cells that coexpress BRAF(V600E) and mutant RAS.
Full-textDOI: · Available from: Poulikos I. Poulikakos, Sep 25, 2015
- SourceAvailable from: Farrukh Afaq
[Show abstract] [Hide abstract]
- "Moreover, the use of BRAF inhibitors comes with many troubling side effects, including development of keratoaconthomas and invasive squamous cell carcinoma [52] [55]. These proliferations occur in BRAF wild-type cells with mutated RAS and are due to up-regulation of BRAF-CRAF leading to ERK1/2 hyperactivation [32] [63]. This paradoxical ERK1/2 hyperactivation has been shown to lead to the development of RAS-driven squamous cell carcinomas and keratoaconthomas while patients are on vemurafenib and other BRAF inhibitors and, as mentioned above, is thought to be responsible for the inefficacy of BRAF inhibitors in NRAS mutant melanoma [64]. "
ABSTRACT: Melanoma is the least common form of skin cancer, but it is responsible for the majority of skin cancer deaths. Traditional therapeutics and immunomodulatory agents have not shown much efficacy against metastatic melanoma. Agents that target the RAS/RAF/MEK/ERK (MAPK) signaling pathway-the BRAF inhibitors vemurafenib and dabrafenib, and the MEK1/2 inhibitor trametinib-have increased survival in patients with metastatic melanoma. Further, the combination of dabrafenib and trametinib has been shown to be superior to single agent therapy for the treatment of metastatic melanoma. However, resistance to these agents develops rapidly. Studies of additional agents and combinations targeting the MAPK, PI3K/AKT/mTOR (PI3K), c-kit, and other signaling pathways are currently underway. Furthermore, studies of phytochemicals have yielded promising results against proliferation, survival, invasion, and metastasis by targeting signaling pathways with established roles in melanomagenesis. The relatively low toxicities of phytochemicals make their adjuvant use an attractive treatment option. The need for improved efficacy of current melanoma treatments calls for further investigation of each of these strategies. In this review, we will discuss synthetic small molecule inhibitors, combined therapies and current progress in the development of phytochemical therapies. Copyright © 2015. Published by Elsevier Ireland Ltd.Cancer Letters 01/2015; 359(1). DOI:10.1016/j.canlet.2015.01.016 · 5.62 Impact Factor
[Show abstract] [Hide abstract]
- "Modèle in vitro, modèle in vivo, tumeurs humaines 16—20 Augmentation de l'expression RAF de type sauvage Modèle in vitro [21] Hyperexpression de la protéine agoniste COT Modèle in vitro, tumeurs humaines [23] Surexpression des récepteurs membranaires PDGFR-␤ et IGF-1R "
ABSTRACT: In patients with melanoma positive for the BRAF V600 mutation, clinical response to specific BRAF inhibitors is usually rapid and striking, with significant benefits in terms of progression-free survival and overall survival. However, resistance to treatment almost invariably arises, typically within a median timeframe of 6 months. Indeed, very few patients exhibit long-lasting response to these targeted therapies. It is essential to better understand the mechanisms of resistance to targeted anti-BRAF therapies in order to increase both response rates and the duration of clinical response to treatment. This literature review describes the signaling pathways involving BRAF and presents recent data from clinical trials with these molecules. Furthermore, we aim to describe the main resistance mechanisms linked with targeted anti-BRAF therapies. The keywords (resistance, BRAF, melanoma, targeted therapy, vemurafenib, and dabrafenib) were used to extract relevant articles in the Medline/Pubmed database published before 31 January 2014. Improved knowledge and understanding of the mechanisms of resistance to targeted anti-BRAF therapies should enable the development of new therapeutic strategies in order to overcome such resistance and allow more significant and sustained response rates to be achieved among melanoma patients. Copyright © 2014 Elsevier Masson SAS. All rights reserved.Annales de Dermatologie et de Vénéréologie 11/2014; 141(11):671-81. DOI:10.1016/j.annder.2014.06.021 · 0.92 Impact Factor
[Show abstract] [Hide abstract]
- "However, due to the fact that in BRAF (and NRAS) wild-type melanoma five times more mutations are observed (or needed) it may be speculated that the relative specificity of BRAF/NRAS mutations for the disease is quite high.9 Most of the mutations of BRAF are found in exon 15, at codon 600 (V600).10 In about 75% of the mutations in that area valine is substituted by glutamic acid (V600E). "
ABSTRACT: Whereas thin melanomas have an excellent prognosis after sufficient surgical treatment, melanoma disease in advanced stages is still a therapeutic challenge. After decades of frustrating studies, new therapeutic strategies have come up in the past few years. On the one hand, increasing insights into the molecular aberrations in melanoma have led to specific "targeted" therapies to affect only the mutated tumor cells, as in many other types of cancers. Today there are few "targeted" substances which are already approved and successfully used for single or combination therapy, but many others are under development. While on the other hand, nonpersonalized strategy substances have been developed successfully inducing an immunologic tumor response. Both kinds of therapy have been found to result in an improvement not only of the response rate, but also of the overall survival in metastatic disease, which represents a milestone in melanoma therapy. However, using these therapies there is still much to learn regarding the effects, the side effects, and the limitations of these promising substances.Cancer Management and Research 09/2014; 6:349-56. DOI:10.2147/CMAR.S49494


text:
Request an OSDBU Speaker or Booth at your event. Interested in making OSDBU a part of your event? Please complete the VA OSDBU Conference Invitation Request. Requests can be emailed to firstname.lastname@example.com. Please allow 10 business days for final decision.
|Disabled Veterans Business Alliance: 4th Annual Procurement Conference: Turning Contacts into Contracts
|October 2, 2015
|SoCal Energy Resource Center
9240 Firestone Blvd
Downey, CA 90241
|Panel Discussions, Workshops, Elevator Pitch Contest, Roundtable Matchmaking. Registration closes September 23, 2015. Register today
|Vendor Industry Participation Webinar for VA's Next Generation Medical Surgical Prime Vendor (MSPV) Catalog, Blanket Purchase Agreements (BPAs), and Contracts
|October 6, 2015; 2 p.m. (EST)
|Regina McGregor with courtesy copy to Adam Spacht
VA Strategic Acquisition Center (SAC) is hosting a webinar to provide information and begin an exchange with industry to improve participation/competition in the VA Next Generation MSPV Catalog Program.
The planned exchange of information seeks to improve the understanding of VA requirements and industry capabilities, thereby allowing potentially interested parties to judge how they can satisfy VA requirements and enhance VA's ability to obtain quality supplies and related services at reasonable prices.
Additionally, the planned exchange of information with industry seeks to increase efficiency in proposal and/or quotation preparation, evaluation, negotiation, and contract award/agreement.
A two-hour agenda is planned. During the webinar, SAC will introduce the following topics:
- Veterans Health Administration (VHA) MSPV Catalog Mandatory Usage Policy Memorandum
Registration Instructions:
Registration is on a first-come, first-serve basis. Registration closes at 12 p.m. on October 1, 2015–or when all available Adobe Connect lines are registered.
Each company is authorized to register for one Adobe Connect line. (Note: There are no prohibitions on how you utilize your connection: e.g., multiple participants in a single conference room.)
To register, please email Regina McGregor with a courtesy copy to Adam Spacht.
Access additional information on the Federal Business Opportunities (FBO) Web site via the following categories:
• Medical
|October 8, 2015
|California State University, Fullerton.
Titan Student Union
800 N. State College Blvd
Fullerton, CA 92834
|Lin Stuart
|Hosted by American Express OPEN, Women Impacting Public Policy and the US Small Business Administration, the ChallengeHER events are free, half-day events to help empower the success of the Women-Owned Small Business Federal Contracting Program. The Contract Connections sessions provide buyer/seller matchmaking opportunities, along with networking opportunities. The ChallengeHER events also provide interactive workshops (with topics such as Federal Contracting Panel, WOSB program, etc.) with speakers and panels composed of Federal, State and Local Government Officials as well as successful WOSBs. Our program provides education for both, small business owners who are new to government contracting as well as experienced contractors.
|10th Annual Small Business Forum
|October 13, 2015
|Proud Bird
11022 Aviation Blvd
Los Angeles, CA 90045
|Nicole Tapia
|10th Annual Small Business Forum, VA will be sharing information about the contracting program, with a focus on information about the fiscal year 2016 procurement budget, small business goals, and benefits for small businesses. This event is intended to assist small businesses in gaining helpful insight in federal contracting, opportunities with the Department of Veterans Affairs, opportunities with US Army Corps of Engineers, and large business prime contractors.
|Business Matchmaking
|October 28, 2015
|Double Tree
201 E. McArthur Blvd
Santa Ana, CA 92707
|Linda Coletti
|Hosted by Union Bank and cooperation from the U.S. Small Business Administration, Small Business Development Centers, PTAC: Bring together 100 primarily woman, minority and disabled veteran-owned small businesses in the Santa Ana/Orange County, California area to meet federal, state, and local government agencies as well as national and local corporations. Event and Registration information
|2015 National Veterans Small Business Engagement
|November 17-19, 2015
|David L. Lawrence Convention Center
1000 Fort Duquesne Boulevard
Pittsburgh, PA 15222
NVSBE is the premier event for Veteran-Owned Small Businesses (VOSBs) and Service-Disabled Veteran-Owned Small Businesses (SDVOSBs) to connect with Procurement Decision Makers (PDMs), program specialists, and contracting experts from the federal and commercial marketplaces. Please visit nvsbe.com for more information.
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Last updated September 30, 2015

subset: commoncrawl


text:
11 December 2013
Overcoming the pain of a family suicide and becoming stronger.
And I hurt.
I hurt because I never had the time to get to know him better.
I was five when I lost my dad; when he took his own life.
I didn't really know him because I'd only spent a small amount of time with him, and most of that I was too young to remember.
It's hard for me to understand why he did it.
I can't remember many details. I think my mind is protecting me from the pain.
When I lived at home in Broome with my family, I was reminded of it all the time and it really affected me.
So my mum made a change for me.
She sent me to school in Alice Springs.
I go to school at Centralian Senior College and I live at an Aboriginal boarding school.
It was hard at first, being 3,000 ks from home, but I'm glad my mum did this for me.
I like it here; I have good friends and I don't think so much about dad.
If I was still in Broome now, I think I would go off track because of everything that has happened to me.
I think that Dad's suicide really made a huge impact on my family, and me most of all, because I was his only child.
I've been attending Yirara for five years now.
I don't get homesick anymore, and my life ahead is much clearer for me.
It's great.
With my Mum and stepdad's help I have become stronger and determined to be the best person for myself.
With the school's help and my friends around me, I know I'm going to be strong and do well.
To talk to someone about grief or depression, remember that headspace.org.au, Lifeline (13 11 14), Kids Help Line (1800 55 1800) , Reachout (au.reachout.com) and BeyondBlue (beyondblue.org.au) are all good places to start.
topicsheywire, rural, youth, rural youth, winner2013, winner-feature, suicide, mental health, family, indigenous
Heywire Winners
Hafiza Akbari
Australia:SA:Renmark 5341
The hardest thing about immigrating from Pakistan, was leaving my best friend
Natasha Banks
Australia:VIC:Ararat 3377
Overcoming isolation the family farm and building resilience through volunteering with the Country Fire Authority
Kelly Brebner
Australia:QLD:Sarina 4737
Sarina may be a sleepy town, but it's a crucial part of a massive international trade
Daniel O'Brien
Australia:QLD:Wamuran 4512
Dreaming of becoming a surgeon, my first task was to wash a naked person
Taihla Lavelle-Briggs
Australia:NSW:Murwillumbah 2484
I will teach my children to be proud of their Aboriginality and to respect single race
Hannah Brown
Australia:QLD:Prairie 4816
The lengths we go to to keep our heard alive during the drought
Trent Caldwell
Australia:WA:Broome 6725
A severe accident taught me what it really means to be tough
Olivia Carmody
Australia:VIC:Barnawartha 3688
The most passionate member of the Barnawartha Football and Netball Club
Jessica Carolyne
Australia:QLD:Surfers Paradise 4217
Moving to get better psychological care and rebuild my life
Thandiwe Chindove
Australia:NSW:Newcastle 2300
Coming to Newcastle as an international student and standing up to racism
Shuarnee Craig
Australia:VIC:Mildura 3500
Drugs almost ruined my life, but I turned a corner for my mum
William Egan
Australia:TAS:Perth 7300
Dispelling the misconceptions and confusion surrounding diabetes
Ella Graham
Australia:SA:Port Pirie 5540
Rebuilding after losing our home and farm in the Mount Remarkable bushfires
Michaela Hague
Australia:NSW:Lake Cargelligo 2672
Every animal has a paddock, every grain has a place to be, but where do I fit?
Charles Harris
Australia:QLD:Longreach 4730
The Longreach races embody the spirit of rural Australia
Preston Harrison
Australia:NT:Ngukurr 0852
I want to be a community policeman so I can help people to get home safe
Jake Hoffman
Australia:QLD:Crows Nest 4355
Isolation and online dating: from Crows Nest to California
Britteny Hunter
Australia:QLD:Bundaberg 4670
Coming face to face with homelessness during the Bundaberg floods
Bradley Hayward
Australia:NSW:Kempsey 2440
Finding the unusual twin passions of agriculture and lighting got me back on track
Sobri Ibrahim
Australia:WA:Christmas Island 6798
Traveling to Perth, our volleyball team shows the mainlanders that Christmas Island is more than a detention centre
Melissa Kelly
Australia:QLD:Ravenshoe 4872
Dirt bike riding in Ravenshoe helps me relax from the pressures of school
Justice King
Australia:QLD:Mount Isa 4825
Dad and I putting our lives back together and taking on the world
Teyen Key
Australia:VIC:Stratford 3862
Gippsland is a great place for me to follow my passion for extreme sports photography
Katie McAllister
Australia:WA:Albany 6330
Our debating team is putting regional students on the agenda
Ezekial Morton
Australia:NT:Alice Springs 0870
Becoming a proud stockman like my grandfather Banjo Morton
Brittany Reinke
Australia:WA:Esperance 6450
The Reinke family tradition: working in the shearing sheds with my dad
Emily Secker
Australia:SA:Port Lincoln 5606
Boarding in Port Lincoln means I have forty brothers and sisters
Hannah Schofield
Australia:NSW:Broken Hill 2880
The stars in Broken Hill help me remember my brother


text:
Hilton Garden Inn Wooster
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Day 28 - Amish in Holmes County
... next town, Berlin. Visiting an Amish bakery, a local cheese factory with tasting, the Wendall-August Metal Imprinting shop, and a herritage center to get some more information about the Amish and Mennonite culture.
People in this area are extremely crafty, lots of local produce, hand-made furniture, arts+crafts, all reasonably priced.
Airplanes, Cheese Donuts and Classic Cars
... One touching story was the background behind Lee Kissler's famous painting, The Hand. Lee was a WWII prisoner-of-war at Stalag XVII-B. To see the artwork and story, click here.
We sat in a Goodyear blimp gondola while Bob explained the difference between a blimp and a zeppelin (A blimp is ...
Day 41-'Is thatyouraccent?!'
... the fact it was called 'Dari Land'.
Wooster is slightly more happening than other places. Went to Broken Rocks Caf� with was a little swanky for us AND let us order off the menu so had choice of food other than fries/burger although I did have that at lunch.
It's now 7.30 and I have put on my pyjamas and eating chocolate in bed. ...
Arrived Safe and Sound and very Proud!!
... never any range anxiety because I always had between 60-100 miles left when I reached the next charger. The car routes thru the Superchargers so no problem finding and getting to them. It was much easier than I thought it would be. The total cost of fuel $ 0 !!! So much fun,looking forward to driving home in a few ...
The night before...
... have talked about places like Sri Lanka and Laos, but only time will tell. The exchange rate makes this much easier than you might expect, with the average 4 star hotel costing only about $40 a night, and an average meal for two running only about $8. In Vietnam, the exchange rate is 21,500 VND for every $1 USD, making us literally millionaires, a stark contrast to our trips to Denmark and ...


text:
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text: What is the flight length from Manchester to Djeba? I am confused as Thomas Cook & Manchester airport say it's 4.5 hrs but on here it seems to be 3 to 3.5 hrs! Flying out next August with Nouvell air as Thomas Cook seem to be using them as their carrier now.


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Jun 5
Our first time at this venue! We are the first of three bands for the evening. Music starts at 9:00p sharp! 21+ $8
May 15
May 9
Opening for Maud in Cahoots.
Apr 25
EY&C @ Rockwood Stage 1 No Cover - tip bucket. 21+ 1 drink minimum
Apr 15
Tax Day Show! We are on at 8!
Sounds Like: Joshua James, Neil Young, The Decemberists, City and color, The Lumineers
Manager: Serge Espitia
Bio: Listening to New York singer-songwriter Emerson Young, it quickly becomes apparent that you're experiencing an artist who enjoys an inherent confidence not only in his music but in himself as well.
That self-assuredness is no accident. It is the result of an individual with deep and diverse musi...See Full Bio
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Sharon Raizer
Jamie Mohamdein
"An ecclectic mix of styles featuring engaging harmonies, vivid lyrics, and starkly beautiful melodies."


text:
Celebrity Hair Affair: Jennifer Lawrence
Jennifer Lawrence was nominated for an Oscar as a blonde.
But she'll truly strike it big as a brunette.
Jennifer Lawrence was nominated for an Oscar as a blonde.
But she'll truly strike it big as a brunette.
Lady Gaga is the latest celebrity to try out the spring's hot hair trend, but in true Mother Monster fashion, she's rocking it in a unique and unusual way.
The 25-year-old star stepped out in Paris Tuesday night sporting a tri-colored 'do consisting of jet-black bangs and black, orange, and white-striped strands.
Just when we thought seeing Jake Gyllenhaal bald would mark the most surprising celebrity hairstyle change of the week, Blake Lively becomes a redhead!
The Gossip Girl star dyed her famous blonde locks to red. That's reason for concern, right? Or does her hair actually look better in this alternate shade?
Jake Gyllenhaal, who normally flaunts a full head of hair, and quite often a beard and mustache to boot, was recently spotted bald on the L.A. set of his new film.
In End of Watch, he plays a police officer, so it suits the role (as it did when he bic'd it for 2005′s Jarhead). But it's certainly a dramatic shift for the hirsute actor.
The Broadway musical Sister Act premiered last night, as celebrities gathered on the red carpet for a performance based on a movie of the same name.
But one singer stood out from among the other stars lined up for photographers. That's what happens when Adam Lambert rocks a mustache and goatee.
Vanessa Hudgens is turning over a new leaf.
It's unclear if she's looking to move past all the drama of those nude pic leaks or if she just wanted a change, but she's rocking the long hair again!
Wait... Brooklyn Decker has hair on top of her head?!? We've never noticed this before, as our eyes were also distracted by other body parts on this model.
You can see what we mean, right?
When Justin Bieber Tweeted March 5 that "im not shaving for a month so you all can see my mustache, im pumped," Selena Gomez wasn't swooning at the idea.
On the Morning Mash Up on SiriusXM this morning, Gomez explained why she did not encourage her boo to go there: "You've gotta commit," she told listeners.


text:
- Thanks to Mark McCue for providing this solid source!
- The recording chain was: unknown rig/taper > Jay from Mass > Adam > Mark (all Sony D5's)
- All editing and mastering with UAD-1 in 24/88.2.
- Metatagging with Tag&Rename.
- Shnid #24227 was used to patch Set I and II tape flips, 2 min. of Drums
plus the crowd noise before the encore.
- A 24 bit version will be made available.


text:
Sir Max Beerbohm
1 portrait of Sir Max Beerbohm
© National Portrait Gallery, London
Sir Max Beerbohm
by Unknown photographer
velox snapshot print, circa 1937
5 1/8 in. x 3 1/4 in. (131 mm x 82 mm) image size
Purchased, 1992
Photographs Collection
NPG x46600
Click on the links below to find out more:
Sitterback to top
- Sir Henry Maximilian ('Max') Beerbohm (1872-1956), Writer and caricaturist. Sitter associated with 19 portraits, Artist associated with 21 portraits.
Artistback to top
- Unknown photographer. Artist associated with 5671 portraits.
Portrait setback to top
Subjects & Themesback to top
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- Women and the First World War
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Ever have a date look at you sideways because you can't refrain from Instagramming your meal? If you need some persuasion to kick the distracted dining habit, then you may want to visit Eva Restaurant in Los Angeles, California. Owner Mark Gold is running an interesting promotion that'll give you a 5 percent discount on your meal if you check your cell phone at the door.
Gold told Airtalk, a radio show on Southern California's 89.3 KPCC, that he did this for his customers. Gold says, "It's about two people sitting together and just connecting, without the distraction of a phone, and we're trying to create an ambience where you come in and really enjoy the experience and the food and the company."
Of course, this promotion only works if customers are willing to let go of their handset. Would you drop your iPhone off at the door for a discount or would you rather take other measures to coax you to talk and not tweet on your date?
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- Operating system iOS (8)
- Screen size 4.7 inches
- Internal memory 16 GB
- Camera 8 megapixels
- Dimensions 5.44 x 2.64 x 0.27 in
- Weight 4.55 oz
- Released 2014-09-19


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- Hand Spin Drain Cleaner, 5/16 In x 25 FtHand Spin Drain Cleaner,5/16 In x 25 Ft
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Rang & Dale's Pharmacology
With STUDENT CONSULT Online Access
- Humphrey Rang, MB BS MA DPhil Hon FBPharmacolS FMedSci FRS , Emeritus Professor of Pharmacology, University College London, London, UK
- James Ritter, DPhil FRCP FBPharmacolS FMedSci, Emeritus Professor of Clinical Pharmacology, King's College London, and Medical Research Director, Quintiles, London, UK
- Rod Flower, PhD DSc FBPharmacolS FMedSci FRS, Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, UK
A straightforward way to master a complex subject! This bestselling textbook presents all the knowledge you need to get through your pharmacology course and beyond—using a clear and accessible approach that makes the material easy and interesting to learn. Progressing logically from a molecular understanding of receptors and drug actions to the clinical uses of the most important groups of drugs, it delivers the latest information on cannabinoids and rimonabant, Cox 2 inhibitors, pharmacogenetics, biopharmaceuticals, and drug abuse—as well as "lifestyle drugs" such as performance-enhancing substances, botulinum toxin, and Viagra®. And now, online access via STUDENT CONSULT makes it an even more effective learning resource!View full description
Medical and Undergraduate students studying Pharmacology, Pharmacy students
Book information
- Published: January 2007
- Imprint: CHURCHILL LIVINGSTONE
Table of ContentsSection 1. General Principles
1. What is pharmacology?
2. How drugs act: general principles
3. How drugs act: molecular aspects
4. Cellular mechanisms: excitation, contraction and secretion
5. Cellular mechanisms: cell proliferation and apoptosis
6. Method and measurement in pharmacology
7. Absorption and distribution of drugs
8. Drug elimination and pharmacokinetics
Section 2. Chemical Mediators
9. Chemical mediators and the autonomic nervous system
10. Cholinergic transmission
11. Noradrenergic transmission
12. Other peripheral mediators: 5-hydroxytryptamine and purines
13. Peptides and proteins as mediators
14. Nitric oxide
15. Local hormones, inflammation and immune reactions
16. Anti-inflammatory and immunosuppressant drugs
Section 3. Drugs Affecting Major Organ Systems
17. The heart
18. The vascular system
19. Atherosclerosis and lipoprotein metabolism
20. Haemostasis and thrombosis
21. The heamopoietic system
22. The respiratory system
23. The kidney
24. The gastrointestinal tract
25. The endocrine pancreas and the control of blood glucose
26. Obesity
27. The pituitary and adrenal cortex
28. The thyroid
29. The reproductive system
30. Bone metabolism
Section 4. The Nervous System
31. Chemical transmission and drug action in the central nervous system
32. Amino acid transmitters
33. Other transmitters and modulators
34. Neurodegenerative disorders
35. General anaesthetic agents
36. Anxiolytic and hypnotic drugs
37. Antipsychotic drugs
38. Drugs used in affective disorders
39. Antiepileptic drugs
40. Analgesic drugs
41. CNS stimulants and psychotomimetic drugs
42. Drug dependence and drug abuse
43. Local anaesthetics
Section 5. Drugs Used in the Treatment of Infections and Cancer
44. Basic principles of chemotherapy
45. Antibacterial drugs
46. Antiviral drugs
48. Antiprotozoal drugs
49. Anthelminthic drugs
50. Cancer chemotherapy
Section 6. Special Topics
51. Individual variation and drug interaction
52. Unwanted effects and drug toxicity
53. Lifestyle and non-medical uses of drugs
53. Gene therapy
54. Drug discovery and development


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Marco's 26 percent tax rate increase not as bad as it seems, officials say
MARCO ISLAND - A draft Marco Island city budget for 2010 calls for an estimated 26 percent increase in the tax rate, but with declining home values, the bottom line might not be that bad for property owners.
The tax rate proposed by City Manager Steve Thompson in the preliminary budget is $1.75 per $1,000 of taxable property value.
The 2009 tax rate was $1.39 per $1,000 of property value. The rate proposed by Thompson equates to an increase of about 26 percent.
Marco Island Taxpayer Association board member Amadeo Petricca has said that while the tax rate is higher, it's expected when property values are down and the city has had consecutive years of conservative spending.
If the Collier County Property Appraiser's office assessed a home at $1 million taxable value last year, then the Marco taxpayer would have paid about $1,392 in city taxes. This does not include other figures on their tax bill, including taxes paid to the county.
This year, that same home owner, considering the average 10 percent decreased home value estimated by the appraiser's office, will be charged $1,575 in Marco taxes. The actual increase on the bill, therefore, would be about $200.
Thompson said during Monday night's council meeting that the city's budget strategy is for the tax rate to increase but the total dollar amounts collected for 2010 to stay about steady from the previous year.
Thompson delivered a brief, preliminary budget. City Council will discuss the budget in more detail in several meetings in August and September.
The projected tax rate increase came on the heels of the city also projecting a 13 percent utility rate increase in October. That increase is to be discussed further by the council in August with the hopes of minimizing the water rate hikes, council members concurred Monday night.
"It's a staff recommendation and now it's time for council and the community to weigh in," Thompson said after delivering the budget overview.
Following the meeting, resident Pat Santiago said she wasn't shocked or upset about the potential tax rate increase.
"I'd prefer it. It's tax deductible (on federal income taxes) and better than other fees. It's the most transparent way to do it," Santiago said.
Santiago's sentiments have echoed those of many other Marco residents, who have said in previous meetings that if city costs must go up, then charge for them on the property tax bill and not in other types of fees.
Marco Island's city revenue will decline because Marco's taxable property values dropped about 10.4 percent. But also, state contributions, including sales and gasoline taxes, are down by about 12.6 percent, leading to about $430,000 of income loss to the city.
What that means for employees is that Marco salaries will be frozen.
The budget includes nearly $15 million in capital projects, five times the amount in the 2009 budget. Some of these capital projects include bridge repairs, but project details from the budget weren't immediately available.
The city portion of Islanders' property tax bills also will include $1 per $1,000 of taxable property value to pay for debt on the Veterans' Community Park property purchase. Thompson said the city will be paying off this debt until about 2020.
Council will need to finalize the tax rate and budget in September.
In other action Monday, the council discussed possibly accelerating the island's septic tank replacement project.
Council members said they're hoping to reduce the proposed 13 percent utility rate increases and agreed to set up an advisory committee to study the issue further.
The septic tank project began in 2005 and 1,700 more properties of the original estimated 5,600 are left to be added to the system, Public Works Director Rony Joel reported.
Council is to address the utility rate increase and creation of a utility board again in August.
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text: More from SI Report: Dodgers release pitcher Freddy Garcia Report: Dodgers release pitcher Freddy Garcia Marshawn Lynch sports gold cleats for Super Bowl Marshawn Lynch sports gold cleats for Super Bowl Louisville vs. FIU: Game time, live stream, TV coverage Louisville vs. FIU: Game time, live stream, TV coverage Pittsburgh-area high school football player dies after... Pittsburgh-area high school football player dies after... Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Boise State appeal partially granted by NCAA by Scooby Axson Email Posted: Sat Jun. 30, 2012 The NCAA announced that Boise State University's appeal of sanctions has been partially granted for violations that occurred between 2005 and 2009.Boise State's football team lost three spring practice dates this year, 2013 and 2014 and lost three scholarships a year in 2011, 2012 and 2013 for violations involving multiple sports.Boise State said that the scholarship penalties imposed on the program were inconsistent with penalties imposed on other programs in similar cases. "Boise State has acknowledged and accepted the findings in the NCAA report for all of the identified sports. We have approached this case seriously, acted in full cooperation with the NCAA and implemented corrective actions and sanctions," said Boise State president Bob Kustra in a release. "However, we thought it important to appeal these football penalties due to the circumstances of this case and the ruling precedent, and we are pleased that the Appeals Committee agreed in the case of the scholarships. We will await a decision from the Infractions Committee on the final scholarship penalty."The secondary violations by the football program involved 63 incoming players who received benefits that totaled over $4,900. The players have since reimbursed the school. Promoted Stories Comments


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502 E Main St, Glasgow, KY 42141
4 beds2 baths2,991 sqft Edit
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Mid-Range Minor Kitchen Remodel
Estimated value increase: $17.9K
- The average cost for a mid-range minor kitchen remodel in Glasgow is $18,033.
Mid-Range Bathroom Remodel
Estimated value increase: $12.9K
- The average cost for a mid-range bathroom remodel in Glasgow is $15,316.
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Homes like this sold for $74-165K.
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- Single Family
- All time views: 146
- Floor size: 2,991 sqft
- Zillow Home ID: 2133095636
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Neighborhood: 42141
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- 601 E Main St3 beds, 2 baths
1,756 sqft, 33,105 sqft lot, built in 1928
- 618 E Main St2 beds, 1 baths
1,204 sqft, 7,840 sqft lot, built in 1950
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- 705 E Main St3 beds, 1 baths
1,260 sqft, 7,840 sqft lot, built in --
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-- sqft, -- sqft lot, built in --
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- 101 E Leech Ave3 beds, 2 baths
1,392 sqft, 12,196 sqft lot, built in 1966
- 101B Embark Ct # 110B2 beds, 1 baths
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- 101B Embark Ct # 100B2 beds, 1 baths
800 sqft, -- sqft lot, built in --
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- 100 Quail Ridge Cir # 27067877842 beds, 1.5 baths
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|Other Units in this Building (1)
|Learn more about 502 E Main St
Nearby Schools in Glasgow
GreatSchools ratings give an overview of a school's test results. The ratings are based on a comparison of test results for all schools in the state.
Disclaimer: School attendance zone boundaries are supplied by Maponics and are subject to change. Check with the applicable school district prior to making a decision based on these boundaries.
School Rating
Glasgow High (assigned)9-121.5 mi
PK-61.8 mi
6-120.4 mi
Data by GreatSchools.org
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text:
Reginald Garton Wilberforce
1 of 2 portraits of Reginald Garton Wilberforce
Reginald Garton Wilberforce
by Southwell Brothers
albumen carte-de-visite
3 1/2 in. x 2 1/4 in. (89 mm x 58 mm) image size
Given by Ripon College, 1976
Photographs Collection
NPG Ax10064
Click on the links below to find out more:
Sitterback to top
- Reginald Garton Wilberforce (1838-1914), Vicar of Lavington, Sussex; son of Samuel Wilberforce. Sitter in 2 portraits.
Artistback to top
- Southwell Brothers (active 1862-1876), Photographers. Artist associated with 196 portraits.
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text:
1996 Dodge Ram
I have a 1996 dodge ram with automatic tranny, and a manual push button for over drive. It drives fine on the highway until about 50, then it gets rough and you have to push it into manual over drive? What could be causing this? HELP?
March 8, 2007.
March 8, 2007.
Give your ignition switch a quick on off on off on. If you have an acc. Selection on your ignition it would be acc on acc on acc on. After that it should blink some. Like blink blink (pause) blink blink blink. Which would be 23. Long pauses are a switch to a diff number. Sry if its confusing.
Mar 11, 2007.
Mar 11, 2007.
What is the whole on off thing suppose to do? I am wondering if it could be my Tranny, or possibly a sesnor? Whatcha think?
Mar 13, 2007.
Mar 13, 2007.
Its something in your transmission. Like a temperature sensor, maybe not, but its def in the trans. When a car gets to a certain speed something is to click over in the tranny to allow for more efficient driving. Something inside yours isnt doing that automatically. Have a highly trusted shop take a look at it.
Also the on off deal is to get computer codes directly from your computer. Via the service engine light.
Also the on off deal is to get computer codes directly from your computer. Via the service engine light.
Mar 13, 2007.
Mar 13, 2007.
When i start my truck i hear and ticking noise and it does NOT go away after it warms up or it does not go away at all. When i accelerate the ticking noise gets faster and when im ...
5 answers • 2010 Chevrolet Suburban • 143,000 miles
I am replacing my engine in my 2003 Hyundai Tiburon. It is a 4 cylinder vehicle, but all the engines I am able to find are 6 cylinder engines. Is it possible to replace a the 4 cylinder...
1 answer • 2003 Hyundai Tiburon • 132,000 miles
If i took out my 91 toyota carolla engine what other cars would it be compatible with?
4 answers • 1991 Toyota Corolla
1990 Toyota Camry mileage: 150,000. 1. The oil warning light is on. 2. There are four quarts of oil in the car. 3. The oil filter is dry. 4. The engine sounds rough. 5. There is noise ...
3 answers • 1990 Toyota Camry • 150,000 miles


text:
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Joe Stevens
Tom Hiddleston Reveals Why He Was Cut From Avengers: Age Of Ultron
'Avengers: Age of Ultron' would've been just as successful with or without the inclusion of the hugely likeable Tom Hiddleston (we think), but now the actor's revealed why he was cut from the movie. Speaking to Digital Spy, the charming Brit who plays the devilish Loki in the Marvel Cinematic…Mike P Williams
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Why Warren Buffett Uses a "Biblical Money Code"
Certain investment titans, such as Warren Buffett and John Templeton, have already used this code to amass billions. Learn their secrets here.
Batman v Superman: Jesse Eisenberg Actually Playing Lex Luthor Jr
Jesse Eisenberg won't be portraying the Lex Luthor we all know and love in next year's 'Batman v Superman: Dawn of Justice'. In fact, Eisenberg will playing Alexander Joseph Luthor Jr, son of Lex Luthor Snr, who has taken over his father's company and turned it into a tech giant. The unexpected…Ben Skipper
Ellen Page Set To Star In Remake of Flatliners
There have been murmurs for some time that a remake of 'Flatliners,' director Joel Schumacher's 1990 supernatural thriller, was in the works at Sony. Now, Variety report that Ellen Page is in talks to take a leading role in the film. The original 'Flatliners' boasted a high profile 'Brat Pack' cast…Ben Bussey
Review: 'Steve Jobs' plays man versus machine
When is someone going to open a window in Aaron Sorkin's "Steve Jobs"? Alas, wrong operating system.Associated Press
China Box Office: Local Titles Dominate Holiday Weekend
Local films dominated the Chinese box office over the holiday weekend, accounting for over 90% of the week's total.Variety
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KBB's 10 Favorite New Car Models of 2015
2015 brings us dozens of new cars, trucks and SUVs. KBB's experts have done the research and determined their 10 favorite new models of the year.
Endemol Shine CEO Defends TV Business: "We Have Never Had It So Good" – Mipcom
In her first major speech since taking over the post of CEO of Endemol Shine Group, Sophie Turner Laing today sounded a defense of the TV business, and offered up considerations for the future of the fast-evolving landscape. In a talk that might have been just as suited for the UK's prestigious…Deadline
Drive-in movie art (16 photos)
This artist is a real Car -avaggio, making amazing hyperrealistic works inspired by drive-in theaters that depict real-life moments at the movies . Czech artist Andrew Valko, 58, created these stunning film-scene paintings after visiting drive-ins across the U.S. (Caters News) Artwork by Andrew…Yahoo News
Fox Developing Couples Dancing Show As 'So You Think You Can Dance' Awaits Renewal Decision
Fox has put in development a couples dancing competition show from former The Voice executive producer Stijn Bakkers and American Idol producer FremantleMedia North America. Created/executive produced by Bakkers and Toby Gorman, EVP Alternative at FMNA, the untitled show highlights the lives of…Deadline
'Furious 8' Director Shortlist Down To Last Few
The search for the director of Furious 8 is down to the last few. No deals have been made. No offers have been made. No decisions have been made. Here is who we have been hearing is legitimately in the mix: Louis Leterrier, Will Eubank, F. Gary Gray. Other director who have been considered are…Deadline
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'Kilo Two Bravo' Director & Writer Ink With Verve
EXCLUSIVE: Kilo Two Bravo director Paul Katis and writer Tom Williams have signed with Verve, the lit agency said today. The war drama, BAFTA nominated this past year when it was known as Kajaki: The True Story , recounts the story of a platoon set out to disable a Taliban roadblock. On nearing…Deadline
GoPro Steals the Show in Fox's "The Martian"
Action camera maker GoPro (NASDAQ: GPRO) landed a starring role in Twenty-First Century Fox's (NASDAQ: FOX) The Martian, which made an impressive $55 million during its opening weekend. In the movie, Matt ...Investopedia
Argo: The True Story That Inspired the Movie
Here's how Hollywood movie magic helped save lives in a hostage situation.Scripps Ulive
Jeanne Tripplehorn, Callum Keith Rennie Join Cast of 'Little Pink House'
Production on the film is about to begin in Vancouver.The Hollywood Reporter
How to Double Your Money Every 3.5 Years
In a recent study, a group of University professors show how 539 individual investors were able to consistently double their money every 3.5 years.CrowdabilitySponsored
PFW Photo Diary: Roger Vivier Gets Groovy
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Busan: Gitanjali Rao's 'Bombay Rose' Blooms With France's Les Films d'Ici
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MTV's Nicole Byer Pilot Casts Sophie Von Haselberg, Fahim Anwar & Rachel Hilson
EXCLUSIVE: Sophie von Haselberg, Fahim Anwar and Rachel Hilson have been cast as series regulars opposite Nicole Byer in MTV's untitled Nicole Byer pilot. They join previously cast Kimrie Lewis-Davis. Byer plays a young adult who is forced to move in with her sister and four kids in the suburbs…Deadline
Family of late actor Robin Williams reach settlement in legal dispute
By Piya Sinha-Roy LOS ANGELES (Reuters) - The widow and children of late Oscar-winning actor Robin Williams, who died by suicide last year, have reached a proposed settlement after a bitter dispute over his estate, according to court papers. The settlement, filed in San Francisco Superior Court on…Reuters
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Kirsten Dunst Thinks TV Is Way Better Than Film
Kirsten Dunst just joined the growing chorus of folks who say that, when it comes to creativity, TV now trounces the movies. In an interview with The Guardian -- pegged to the imminent premiere of Season 2 of FX's "Fargo," in which Dunst stars -- the actress said that "the movie industry is in a…Huffington Post
Phil Craig Exits Discovery Networks International After Eight Months As VP/Chief Creative Officer
Not quite a year after he was announced, and only eight months after assuming the job, Phil Craig is bowing out as VP and chief creative officer of Discovery Networks International. News broke as Craig was attending MIPCOM. "Phil Craig has decided to step down from his role as EVP & Chief Creative…Deadline
Relativity President Tucker Tooley Resigns
Relativity Media president Tucker Tooley, who helped guide the company for the last eight years and through a two-month-long bankruptcy, is leaving the company in 30 days, Relativity CEO Ryan Kavanaugh and Tooley announced Monday. The departure comes just as Relativity is trying to win approval for…Variety


text:
Germantown, MDUSA
July 27, 2013
About us…
Amnesty International USA Washington, DC Chapter supports Amnesty International USA's vision of a world in which every person enjoys the rights enshrined in the Universal Declaration of Human Rights and other international human rights instruments. We organize events? such as concerts, protests and vigils? that raise awareness of human rights violations and inform the public about what can be done to oppose these violations. We also advocate on behalf of prisoners of conscience and other victims of human rights violations at every meeting by participating in Amnesty's ongoing urgent action letter writing campaign.
The Groups of the Washington DC Chapter meet on Tuesdays in Cleveland Park, Adams Morgan, and Capitol Hill, SE, DC.
We welcome new members, ideas and interests and encourage you to check our calendar for next general meeting or event!
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The next three "Avatar" films have added yet another familiar face: Sigourney Weaver.
The Oscar-nominated actress will join fellow "Avatar" alumni Sam Worthington, Zoe Saldana and Stephen Lang in the upcoming all-new trilogy, directed and shot simultaneously by James Cameron — but there's a twist.
"Sigourney and I have a long creative history, dating back to 1985 when we made 'Aliens,'" Cameron said of Weaver's return. "We're good friends who've always worked well together, so it just feels right that she's coming back for the 'Avatar' sequels. Her character of Grace Augustine, as fans know, died in the first movie, so she's playing a different and in many ways more challenging character in the upcoming films. We're both looking forward to this new creative challenge, the latest chapter in our long and continuing collaboration."
Well, that answers the question of how Grace Augustine could possibly return in an "Avatar" sequel: She can't. The good doctor Augustine remains dead as a doornail in the new "Avatar" trilogy, leaving Weaver to play a new character instead.
Which opens up a new kind of question: Who will Weaver play in the "Avatar" sequels? Will she play some form of Augustine-Na'Vi hybrid, with trace memories of the woman she used to be? Will Weaver embody the Tree of Souls, or even the divine Eywa herself?
We'll find out more as the "Avatar" sequels start taking shape. "Avatar 2″ is expected to arrive in December 2016.
Who do you think Weaver will play in the new "Avatar" movies?


text:
2013 President's Hall of Distinction Honorees Inducted
Dr. Michael G. Scales, president of Nyack College/Alliance Theological Seminary, hosted a pre-commencement brunch on Saturday, May 11 at the Tarrytown House Estate & Conference Center in Westchester County.
During the gathering, three honorees were inducted into the Nyack College President's Hall of Distinction: Dr. Micheal Flaherty, president and co-founder of Walden Media; Dr. Graham Power, founder and chairman of the Power Group of Companies in South Africa; and Rev. Dr. Thai Phuong, president of the Evangelical Church of Vietnam.
A video clip, featuring Nyack alumnus, Dr. Thomas Stebbins ('56), provided by The Christian and Missionary Alliance was screened and Dr. Stebbins was also on hand as a guest speaker.
Two of Nyack's best and brightest students, valedictorian C. Johannah Ziegler-Ritter and Honors Program student Stuart Guild shared brief remarks about their Nyack College experiences. Special music was performed by Luis Diaz (NC '15) , Janet Miller (NC 09), and Professor Marie Kenote, known as Flutes of Praise, and by Jose Heredia (NC '09) and Jhasoa Agosto ('09), accompanied by Dr. Sue Talley.
Click here to see photos from the event.
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What Makes a Leader? (HBR Bestseller)Leadership & Managing People Magazine Article8.95When asked to define the ideal leader, many would emphasize traits such as intelligence, toughness, determination, and vision--the qualities traditionally...
Extreme Negotiations: Putting the Idea into PracticeNegotiations Digital ArticleIn our November 2010 issue, Jeff Weiss and Jonathan Hughes, along with Major Aram Donigian, authored an article called "Extreme Negotiations." In it, they described the temptations we all face when negotiating under duress — for example, acting too quickly or relying too much on coercion — and suggested that the principles of effective negotiation […]
Leadership Lessons from the Military (HBR Spotlight Article Collection)Leadership & Managing People Article Collection19.95Military work-like business-is risky, pressured, and fast-changing. It calls for absolute clarity about the mission, extraordinary adaptability, and precise...
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Implementing StrategyCommunication VisualThese five strategies—used by the most skilled U.S. military officers in high-stakes situations—can help business negotiators not only to respond quickly at the bargaining table but also to reshape their thinking ahead of the deal.


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Lobster season log, day 1
Likely to be good season
Jimi Olsen 7:30 p.m., Oct. 9
Posted October 19, 2012
Taking you to European destinations on a dime (4 of 7).
An easy 1.5-hour train ride from Rome got us into Florence midday. After gathering our bearings (and a map), we set off to drop our bags off at our flat before exploring the city. We ...


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Village Ln
Eltingville, New York, 10312
Commute to Downtown Carteret
Most errands can be accomplished on foot.
Many nearby public transportation options.
Flat as a pancake, minimal bike lanes.
Score Details
Village Ln has a Walk Score of 74 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
Village Ln is a six minute walk from the SIR Staten Island Railway at the Eltingville stop.
This location is in the Eltingville neighborhood in New York. Nearby parks include Annadale Green, Double Nickel Playground and Sweet Brook Bluebelt.
Explore how far you can travel by car, bus, bike and foot from Village Ln.
Village Ln has good transit which means many nearby public transportation options.
Rail lines:
SIR Staten Island Railway
0.2 mi
Bus lines:
X5 Staten Island - Midtown Manhattan Express
0.2 mi
S79-SBS Staten Island Mall - Bay Ridge
0.2 mi
X4 Staten Island - Lower Manhattan Express
0.2 mi
X1 Staten Island - Manhattan Express
0.2 mi
S89 Eltingville - Bayonne LTD
0.2 mi
S59 Port Richmond - Tottenville
0.2 mi
S55 Rossville - Staten Island Mall
0.4 mi
View all Eltingville apartments on a map.
Village Ln is in the Eltingville neighborhood. Eltingville is the 205th most walkable neighborhood in New York with a neighborhood Walk Score of 64.
Moving to New York from another city? View our moving to New York guide.


text: Josh Birch FilmsAn independent filmmaker offering a creative and innovative approach to film & video productions. PLAN Careful thought and planning is put into place to ensure every small detail has been evaluated and considered prior to production. FILM Using the camera with an artistic vision and variety of grips to deliver fresh content that differs from one project to the next. DELIVER Countless hours are spent in the editing suite fine tuning all the aspects within post production to satisfy each clients demands. About Me I am a freelance filmmaker based on the outskirts of London with experience working both in the UK and abroad with a variety of high profile clients, filming in specific areas of the film industry including: action sports, short film, corporate and weddings. But with an aspiration to break into the commercial and feature film sector. A background in action sports and adventure, with interest in creating video content to acquire commercial sponsorship led on to graduating from Birmingham City University with a First Class Honors in Film Production and Technology. I'm happy to work both under specific direction or offer my ideas and knowledge through all areas of production ensuring each film or video created tells a story that delights the audience. Please contact me via my contact page for any ideas or projects you are considering. Showreel Portfolio AllSSE Alpine Squad DayHeli POV Aerial WorkEvolution Ski CampsBusiness RocksThe Hills Wedding DayBilly Morgan – Season Edit 2014/15Murray Buchan – Welcome To The TeamStrength Of FaithHurstwood Reservoir Biking Some Fun Facts Clients Countries Visited Cups of Tea Testimonials Josh is a very approachable character which makes working with him easier, he really impressed me with his creativity and attention to detailEcho Your Sport, Charles Adeyemi (Founder / Director)Absolutely amazing wedding video. You captured all of the emotions we all experienced throughout the whole day. Thank you so very much!Carolyn & Steve Hill, Josh is a big name and massively respected on the British Freeski scene and has always been super passionate about filming and editing. Therefore he's always been our first choice of person to get involved for filming the latest Grom Camp edit. He is also one of the biggest perfectionists I know meaning he never stops until the job is done right" Salomon Grom Camps, Pat Sharples (Founder / Director)"We sub contracted Josh Birch as a second camera operator on a recent project we were filming. Josh's huge scope of practice and experience soon came to light and subsequently further employed him as our lead camera operator and used him extensively in the post production side of the project. I would have no hesitation in recommending his services."Out the Nest, Nathan Connolly (Director) Get In Touch +44 07779047833 firstname.lastname@example.com Locate Me on A Map


text:
Recent Comments
- 1 year ago Once more
- 1 year ago Trying again
- 1 year ago Worth a shot I suppose
- 2 years ago Could use an upgrade of a phone. What kind of apples are we talking though?
- 2 years ago I am kinda hoping for Retro to be working on the new Zelda game and LINK TALKS
- 3 years ago This is just getting annoying
- Member for
- 4 years 1 month


text:
editor's review
SymMover is an intelligent method of migrating your data between drives, generating a symbolic link between the source and the destination folders.
This benefits scenarios where you're moving entire folders of software and games to another drive, which normally may cause behavioral issues, but with SymMover this is easily overcome. By creating a link between the locations, Windows will point to the right folder in any situation.
It comes wrapped up inside a simple, yet clean and intuitive interface that is easy to operate. A new migration task can be initiated by the press of a button, which triggers a dialog that allows you to select the data to be transferred.
What's really great is that the program provides you with a list of installed programs, allowing you to migrate them seamlessly, without the need to manually browse for their path. There's even a search function that allows you to locate a program or a game in a faster manner.
The output folder can be set from the Settings button; by default, it is a directory that was created by the application automatically, but you can modify this with ease.
You can also select the type of migration to be performed, namely normal (the files are moved and a shortcut link is generated) or keep in source (which means more of a copy operation, seeing as the original files are kept), whichever suits you best.
The migration process occurs at an average transfer rate and note that large quantities of data might take a while to complete.
Overall, SymMover seems like a good asset, worth trying when you need to migrate data without causing compatibility issues for the software and games installed on your system. It lacks scheduling options and could use a more appealing interface and more explicit commands.
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About Uttermost The mission of the Uttermost Company is simple: to make great home accessories at reasonable prices. This has been their objective since founding their family-owned business over 30 years ago. Uttermost manufactures mirrors, art, metal wall art, lamps, accessories, clocks, and lighting fixtures in its Rocky Mount, Virginia, factories. They provide quality furnishings throughout the world from their state-of-the-art distribution center located on the West Coast of the United States.


text:
Facebook Smashes Wall Street Expectations in First Quarter
UPDATED: The social network also announced that CFO David Ebersman will step down in June.
Facebook beat analyst expectations Wednesday when it reported first-quarter profits of 34 cents per share excluding certain items on revenue of $2.5 billion.
Wall Street had expected Facebook to report per-share earnings of 24 cents on 60 percent rise in revenue to $2.4 billion. Instead, revenue was up 72 percent from the same period last year.
Revenue from advertising remained the largest money maker for Facebook. Ads brought in $2.27 billion for the social network during the quarter, up 82 percent from the same period last year.
Net income was $642 million, up 193 percent from $219 million during the first quarter of 2013.
Daily active users on the site continued to climb, growing 21 percent to 802 million on average. Monthly active users grew 15 percent to 1.28 billion.
Mobile continues to become a more important piece of Facebook's traffic. Daily active users from mobile devices grew 43 percent to 609 million. Monthly mobile active users were up 34 percent to 1.01 billion.
Facebook also announced that CFO David Ebersman will step down in September after less than two years with the company. He will be replaced June 1 by David Wehner, currently Facebook's vp corporate finance and business planning. Ebersman, who previously was CFO of Zynga, will remain with the company until September to help with the transition.
In a conference call with investors, CEO Mark Zuckerberg called Ebersman "a great partner in building Facebook." Ebersman joined the company in the lead-up to its initial public offering, and Zuckerberg noted that he "set us up to make the long-term investments that we need."
Ebersman noted during the call that he plans on returning to the health-care sector, where he spent most of his early career.
"This was a hard decision for me because of how much I love Facebook and all the people I work with here," he said. "I'm confident that Facebook's best days lie ahead."
Facebook looks like a markedly different company after its first quarter than it did at the end of last year. In February, the Palo Alto social network paid up to $19 billion for messaging service WhatsApp. It followed that purchase with its $2 billion acquisition of virtual reality firm Oculus VR in March.
The Federal Trade Commission on Wednesday approved Facebook's purchase of the Irvine gaming headset maker, which Zuckerberg has said he plans to use as a broad software platform.
Facebook shares closed down $1.67, or more than 2 percent, to $61.36 on the Nasdaq but after the closing bell were trading up $1.50.
Twitter: @NatJarv
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text:
Valerie's Tuscan Vegetable Soup
Valerie Bertinelli loves this soup because it is only 63 calories per serving, including the sprinkle of Parmesan cheese.
Total Time:
Level: Easy
Yield: 4 main-dish servings
Serves: 4
Advertisement - Continue Reading Below
- 1¼ c. cubed peeled eggplant
- 1 c. water
- 1 can no-salt-added whole tomatoes
- ½ c. sliced fresh mushrooms
- 1 clove garlic
- ¾ c. coarsely chopped zucchini
- ½ tsp. dried Italian seasoning
- salt
- pepper
- ¼ c. freshly grated Parmesan cheese
- In 2-quart saucepan, place eggplant, water, tomatoes with their juices, mushrooms, garlic, zucchini, Italian seasoning, 1/4 teaspoon salt, and 1/8 teaspoon freshly ground black pepper; stir to combine. Heat to boiling on high. Cover; reduce heat to low. Simmer 25 minutes or until vegetables are tender.
- To serve, ladle soup into 4 shallow soup bowls; sprinkle with Parmesan.
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text:
|North Star Quilters Guild -
PO Box 5814 -
Grand Forks, ND 58206
North Star Quilters Guild welcomes everyone interested
in quilting - beginners, experienced, and non-quilters.
Visitors are welcome at meetings and new members may
join at any time.
For information regarding membership, meetings, workshops
or special events, email us at: firstname.lastname@example.com
North Star Quilters Guild meets monthly the first
Saturday of each month (excluding July).
Meeting dates include a business meeting and workshops
which offer the opportunity for fellowship and the support
of other quilters from the surrounding Northern Red River
Our meetings are held at University Lutheran Church
(2122 University Ave., Grand Forks, ND) unless
otherwise noted.
Sometimes special events will require us to meet at a
venue with more space available. This will be noted on
the calendar.
|Celebrating 34 years of quilting!
|Founded 1981
|Quilts & Coffee
is a quarterly-ish
presentation hosted by
NSQG featuring
local and regional
quilt artists.
Pat Knoeche
Tuesday, Sept. 1
6:30 p.m.
Shopping available,too.
All events are held at
First Presbyterian Church
5555 So Washington St.
Admission: $8


text:
You are a fan of scattered inhabitants ? Come to discover the best forums scattered inhabitants on the internet and share your experience with a community fan of scattered inhabitants . You can also build a forum scattered inhabitants and create your online discussion.
A powerful, divine entity claims patronage to each continent, with the lands' inhabitants warring constantly on one another to claim the world for their own God.
polemos, powerful, divine, entity, claims, patronage, continent, lands', #inhabitants, warring, constantly, claim, world
Equestria has been invaded. The sisters have vanished, their warriors defeated, their heroes scattered, and the Griffons have claimed Canterlot and lordship over Equestria.
role, play, little, pony, equestria, grimdark, mane, occupation, dawn, twilight, sparkle, rarity, pinkie, battle, fight, story, lore, friends, dystopian, grim, griffon, kingdoms, griffin, kingdom, fantasy
This rp is a bit of a continuation from another rp, focusing on original characters, but all anime (and others) characters are welcome as well.
#scattered, dawn, continuation, focusing, original, characters, anime, (and, others)
Free forum : In the world of Ultim, Humanity fell millennium ago. From the ashes of man-kind, there rose the creatures of Lore. They have dominated the world that men once called their own.
free, forum, ultim, wars, kingdoms, ultimnew, #inhabitants, humanity, fell, millennium, from, ashes, man-kind, there, rose, creatures, lore, they, have, dominated, world, that
Free forum : The area of Seattle has been inhabited for almost 4, 000 years. The earliest inhabitants were the Duwamish Tribe, and with them, came their legends of the "man-wolf. " Werewolves have inha
free, cruentus, luna, area, seattle, been, inhabited, almost, years, earliest, #inhabitants, were, duwamish, tribe, with, them, came, their, legends
It's been many long years since the rise and fall of the Storm King. He who once called the storm to his command is long ceased and his legacy, the Storm Regalia, destroyed beside his grave. The Regalia have been scattered with the winds and the king
gear, heirs, change, it's, been, many, long, years, since, rise, fall, storm, king, once, called, command, ceased, legacy, regalia, destroyed, beside, grave
three friends, many stories, endless good times, D
scattered_stars, three, friends, many, stories, endless, good, times


text:
Free Shipping
Product Information:
The Naomi loveseat is one of the newest editions and also one of the more versatile and comfortable selections. Upholstered in a vivid olive green color, the Naomi is 100% top grain Italian leather all around. Featuring adjustable back supports that extend to allow for a laid back position in one swift motion. Added for comfort are stitched in plush lumbar cushions. Naomi also comes with ultra soft adjustable arm rests with multiple position capability and chromed stainless steel legs.
Product Details
Weights & Dimensions
|Design: Standard
|Frame Material: Wood
|Upholstery Material: Leather
|Product Type: Loveseat
|Style: Contemporary
|Frame Finish: Chrome
|Upholstery Color: Olive Green
|Number of Items Included: 1
|Print: Solid
|Removable Seat Cushions: No
|Removable Back Cushions: No
|Cushion or Upholstery Fill Material: Down
|Tufted Cushions: No
|Massage: No
Legs Included: Yes
|Nailhead Trim: No
|Toss Pillows Included: No
|Arm Style: Pillow top arms
|Seat Style: Multiple cushion seat
|Back Style: Split back
|Slipcovered: No
|Storage: No
|Console Included: No
|Application: Residential
|Eco-Friendly: No
|Country of Manufacture: China
About the ManufacturerCreative Furniture has always been a company in celebration of style and comfort. What unites their customers is not the size of their business or geographical location, but the attitude and appreciation of style and service.
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You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
I love it. Thank you
Really Fine !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Enjoyed the vocals on Lovin' Those Blues.
Hey Glo, saw you at The Eagles tonight! You and Phil played a great set. You've made two more fans :) Stay blue!
Every womens is unique as a Diamond + so is your Music. Follow me on FB/Twitter! One Love! Michael
Love your music! If you would ever want to play with Mojomatic. Let us know :)
It's Fanship Friday..which means gearing up to a fun and relaxed weekend, and taking the time to remind you of how important it is that you make the great music you do..it gives us, your fans, the chance to listen and be inspired by your sparkling, shiny gold talent. And gives you the chance to keep the World Rockin!!
I made the right Choice this monday morning !
Wow, great musicianship going on here !
Although it rains on London Town
I know today I won't feel down
Cause your music makes me bright and sunny
and one day soon will make you money!
(It's Wednesday Poetry Day here at MWP Headquarters. Please return the favour with your own witty rhyme!)
Inspirational. .
Check out our music.. Hit that FaceBook " LIKE " button if you are feeling it..


text:
Miami, FLUSA
May 15, 2014
app developments
still learning
Bernie King Miami
About us…
Come join developers, designers, data geeks, leaders, and idea-makers who volunteer to help government and civic organizations adopt open web technologies for Miami-Dade County, Florida. We are technology and civic activists fostering community-authored projects. We are inspired by, and eager to contribute to, Code for America's http://brigade.codeforamerica.org/.
a national network of "civic hackers" innovating government & community.
This Co-working space in Wynwood has offered space since our inception!
ServerGrove donates web hosting to PHP-based Code for Miami Projects.
419 Noders
336 MJUGers
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text: A hostel like every other. It's clean and good value. We had the 10 person room which was clean and big. Our room had a own toilet and two shower cabins. Everything worked fine. One sink wasn't working and was poorly fixed. However there were two more. The beds make strange noises when you are moving, but they are comfortable.... More


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Footwear etc. Rewards: Enjoy $10 in Rewards Just for Signing Up!
Select your desired product options and we will notify you when it is back in stock.
The Earthies Treano is a casual women's low boot with buckle accent.
Earthies shoes are beautifully designed and crafted for women who care about their personal health and longevity. Each Earthies shoe comes with a unique wellness footbed with a cupped heel, anatomic arch support, and cradled toe area for the ultimate in fit and comfort.
Earthies Treano Chestnut Leather Women's Shoe
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Let me start by saying that I love Earthies. I have bunions, and a hammertoe, so getting comfortable shoes is difficult. I've found Earthies to be a bit wider in the toe box to accommodate the bunion, without having to size up. This particular shoe isn't as cushioned as other Earthies ankle boots that I have, but this shoe is also a bit more stylish. I was able to wear it all day, commute to work and home, and be comfortable. Yahoo!
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"I really like your site. You have a great selection of shoes and your customer service is excellent. I just ordered my third pair of MBT shoes from you and I recommend both MBT and footwearetc.com highly."
©2015 Footwear Etc. All Rights Reserved. For any questions or assistance call 1-800-720-0572.


text:
Proficient, Experienced & Skilled .Net Consultant
Summary: - 10+ years of IT experience as .Net Consultant / .Net Programmer Analyst with significant expertise in Web/Windows based application design and Development. - Experienced in Microsoft.NET Framework, WCF, Visual Studio 2005 / 2008 / 2010/2012, C#, ASP.NET 2.0/3.0/3.5/4.0/4.5, Web Forms, WinForms, XML, XSL/XSLT, Web Services ,Windows Service, SQL. - Experienced in creating Server controls/User control. - Experienced in Telerik Controls for ASP.Net(RadControls). - Experienced Database skills in MS SQL Server (2005 / 2008) and MySql. - Experienced LINQ, AJAX / JSON / JavaScript / JQuery.\ n- Experienced in Windows Communication Foundation (WCF). - Experienced Object-Oriented Programming skills in C# and PHP. - Experienced with Google Maps API V3 integration and DotNetNuke CMS. - Currently working as a .Net Consultant for a major telecommunication company.


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prints, thomas prints, jefferson prints, memorial prints, washington dc prints, monuments prints, history prints
"Thomas Jefferson Memorial" print by Gene Sizemore. Ships within 3 - 4 business days and arrives rolled in a tube. Choose from multiple print sizes, papers, mats, and frames.
All prints ship in durable cardboard tubes.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality prints. All of our prints are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free papers and canvases with archival inks to guarantee that your prints last a lifetime without fading or loss of color. Paper prints include a 1" white border around the image to allow for future framing and matting. Canvas prints include a 2.5" white border to allow for future stretching on stretcher bars.
Prints ship within 3 - 4 business days in durable cardboard tubes.
This dramitic rendition of the Thomas Jefferson Memorial is really eye catching. This image has been enhanced digitally.
Fine art photography for your home or office. Whether you are looking for famous places or floral photographs, check this site often as art work is added monthly. Gene Sizemore is a part time freelance photographer. Born in Texas and living in Northern Virginia. He lived almost a decade in Europe and travels all over the US. He has only recently assembled some of his work here on Fine Art America for purchase by the general public. Gene is available for event photography in the DC Area. Please contact him at firstname.lastname@example.com for details and availablity.
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text:
Pork Salad With Creamy Lime Dressing
Source: dLife
Pork tenderloin mixed with salad greens, peppers, and mushrooms and topped with a creamy lime dressing.
0 3/4 lb pork tenderloin
0 1/4 tsp salt
0 1/4 tsp black pepper
8 cup Lettuce, crisphead, fresh, shredded
1 each large yellow bell pepppers
0 1/2 lb fresh mushroom slices
16 oz Peas, black eyed peas, pre-soaked
0 1/2 cup fat free sour cream
0 1/4 cup fresh cilantro
2 tbsp fresh lime juice
2 tbsp vegetable oil
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