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ShelterLogic 6x12x8' Sport Shed - in - a - Box
Item # WX2-44574
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Our equestrian tack and supply store has thousands of horse related items for you to browse and compare prices between several online tack stores.
Find Western and English tack, riding apparel, horse vitamins & supplements, as well as a collection of horse toys and gifts.
The Ariat Ladies Ruby Sonara Dark Cloud Jeans feature a dark wash along with hand sanding whiskers and leg chevrons. They also have some stretch as well as heavily embroidered top entry back flap pockets and a zip up coin pocket with a removable suede ta

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Sweet old man!!! Only drinks blended whiskey out of plastic bottles! Have happy holidays! Eat drink and look for my new CD "Einstein" at CD baby and all the usual downloadable outlets!
Poetry? What the hell is that?
"Rex Stratton, Philanthropic musician from the Midwestern USA has given thousands to poor neglected drug addled musicians worldwide. He has done this in an hugely spiritual effort to improve his Karma...he hopes"


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(This story first ran at PressConnects.com) BALTIMORE — At 26 years old, UFC light-heavyweight champion Jon Jones admits it is difficult even for him to realize he could soon be considered the best fighter in the history of mixed martial arts. But it's a reality (…)
Kenny Florian seems to believe the hype surrounding 19-year-old UFC prospect Sage Northcutt. Sage Northcutt quickly won his UFC debut against Francisco Trevino, after he took advantage of an ill-time read news >>
UFC Hall of Famer Chuck Liddell says Jon Jones and GSP have similar 'safe' fighting styles, and would like to see the former LHW champion take more risks in the Octagon. Jon Jones, former pound for p read news >>


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Colorado Cyclist is a leading distributor of bicycle parts and accessories. The company carries hundreds of products, from mountain bikes, road bikes, and bike wheels to bottom brackets, headsets, brake levers, jackets, summer gloves, knickers, base layers, eyewear, and more.


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Est CaffeAugust 22, 2014Café • Hounslow, United Kingdom
Decidedly cobbled together pizza :/
Really great food in this down to earth, friendly pub, and good value too. Try to steak pie and mash.🍴😛
Lovely but slow. Much like Megan Fox.
Like walking into a real pizzeria in the middle of the Italian countryside. Brilliant. Read more


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Parrot cage 63"tall x 32"wide x 23"deep. Suitable for Amazons, Cockatoos, African greys etc. Asking $75. or best offer.
Oct 5 -
Asheville :
Inman - Birds
his name is smokey very sweet and talks up a storm loves attention he does answering machine, his phone number,says over 100 different sayings very tamed 900.00 without cage cage is 200.00 he has never been in any other cage he keeps his own cage clean inside he does not like anything but his toys in cage everything else he will clean out
Oct 3 -
Tri-Cities (TN) :
Bluff City - Birds
Congo African Grey, excellent feather, extensive vocabulary, greater eater, comes with large playtop cage, toys and food.
Oct 1 -
Columbus (OH) :
Columbus - Birds
12 year old DNA sexed male African grey congo parrot, this guy is amazing and can mimic any sound, any voice, he is very talkative, and will dance for peanuts! He is much more male friendly, He isn't handled much currently but can be by a male handler and loves it! Includes, his toys, his cage, food, treats, etc. Good loving home that has time for him a MUST!!!!!!!!
Sep 28 -
Columbus (OH) :
Coshocton - Birds
We have a very well talking African grey male parrot, with papers showing sexed. Included is also a large flight cage. $1500 OBO
Please call 260-327-3240
Sep 28 -
Fort Wayne :
Larwill - Birds
I have a DNA Female double yellow amazon, that has been to the vet twice a year with a good bill of health, she is in good feathers, she is also realty to breed, she comes from a smoke free home, I am asking $7000 for her, also i am w
illing to trade her for a baby african grey or baby macaw if interested call me at 1 812 486 2982 or email me.
Sep 9 -
Evansville-Henderson :
Montgomery - Birds
Beautiful grey solid parrot cage with play gym on top. Large bag of toys as well. Cage in as new condition. Had previously housed an African Grey. Very roomy cage, will not be disappointed.
Sep 5 -
Indianapolis :
Brownsburg - Accessories
Maggie is a Timneh African Grey parrot that was born in 2004. The Timneh African Grey is the smaller of the two species of African Grey parrots. Maggie is a very smart and healthy bird that loves to mimic sounds and talks when she is comfortable with her surroundings. She can be handled but needs more work with being out. Our work schedule keeps us from having as much interaction as what ...
Aug 21 -
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Connersville - Birds
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All posts tagged "Mikael Wardhana"
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Gold Star – Katerina Chang (Chadwick Models) poses in a gold bodysuit for these striking portraits lensed by Mikael Wardhana. Makeup...2012December 4, 2012
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Candy Skies – Australian magazine Karen enlists photographer Mikael Wardhana for a story of colorful fashion starring Lauren Rippingham. Stylist Michael...2012July 2, 2012
- Katerina Chang by Mikael Wardhana in 'Hymn to the Immortal Wind' for Fashion Gone Rogue
Hymn to the Immortal Wind – Sydney-based photographer Mikael Wardhana captures Katerina Chang in a tranquil story of nature and style...2012June 14, 2012
- Maggie Weinheimer by Mikael Wardhana in Clash of Hues
Within a world of bold metallics and feminine frills, Maggie Weinheimer finds her place in front of Mikael Wardhana's lens. Aided...2010August 14, 2010
- The Duchess | Amy, Meggie, Hanalei & Stacy by Mikael Wardhana
Photographer Mikael Wardhana takes to the countryside for his most recent work entitled, The Duchess. A story of contrasts, the black...EditorialMay 3, 2010


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Maybe they should take the word "industrial" out of the Dow Jones Industrial Average.
With the three changes announced Tuesday, the venerable 30-stock index is moving away from companies that actually make real things, like Hewlett-Packard HPQ 2.8402366863905324% Hewlett-Packard Co. U.S.: NYSE USD26.07 0.72 2.8402366863905324% /Date(1443819651006-0500)/ Volume (Delayed 15m) : 15474517 AFTER HOURS USD26.07 % Volume (Delayed 15m) : 101086 P/E Ratio 10.640816326530611 Market Cap 46879724564.7507 Dividend Yield 2.70042194092827% Rev. per Employee 347003 More quote details and news » (ticker: HPQ) and Alcoa AA 2.8077753779697625% Alcoa Inc. U.S.: NYSE USD9.52 0.26 2.8077753779697625% /Date(1443819775264-0500)/ Volume (Delayed 15m) : 27666503 AFTER HOURS USD9.48 -0.04 -0.42016806722689076% Volume (Delayed 15m) : 473099 P/E Ratio 20.042105263157893 Market Cap 12469315658.1735 Dividend Yield 1.2605042016806722% Rev. per Employee 411780 More quote details and news » (AA), to service companies like financial intermediaries Goldman Sachs GS 0.5624360868083172% Goldman Sachs Group Inc. U.S.: NYSE USD177.01 0.99 0.5624360868083172% /Date(1443819637693-0500)/ Volume (Delayed 15m) : 4431332 AFTER HOURS USD177.35 0.34 0.1920795435286142% Volume (Delayed 15m) : 38541 P/E Ratio 10.492590397154713 Market Cap 76622493721.1066 Dividend Yield 1.468843568159991% Rev. per Employee 1132970 More quote details and news » (GS) and Visa v 0.971567366766681% VISA Inc. Cl A U.S.: NYSE USD70.67 0.68 0.971567366766681% /Date(1443819670903-0500)/ Volume (Delayed 15m) : 7307845 AFTER HOURS USD70.75 0.08 0.11320220744304514% Volume (Delayed 15m) : 152590 P/E Ratio 29.66211962224554 Market Cap 171933175601.641 Dividend Yield 0.6792132446582708% Rev. per Employee 1425050 More quote details and news » (V). The other change involves the departure of Bank of America BAC -1.0932475884244373% Bank of America Corp. U.S.: NYSE USD15.38 -0.17 -1.0932475884244373% /Date(1443819716892-0500)/ Volume (Delayed 15m) : 181233303 AFTER HOURS USD15.35 -0.03 -0.19505851755526657% Volume (Delayed 15m) : 605066 P/E Ratio 16.664860764979956 Market Cap 160542899593.02 Dividend Yield 1.3003901170351104% Rev. per Employee 422621 More quote details and news » (BAC) and its replacement by Nike NKE 1.114431074860696% Nike Inc. Cl B U.S.: NYSE USD125.21 1.38 1.114431074860696% /Date(1443819614430-0500)/ Volume (Delayed 15m) : 4511805 AFTER HOURS USD125.21 % Volume (Delayed 15m) : 45399 P/E Ratio 31.69873417721519 Market Cap 107102617509.993 Dividend Yield 0.8944972446290232% Rev. per Employee 496837 More quote details and news » (NKE).
In a press release today, the index committee at Dow Jones, which publishes Barron's, cited the low stock prices of the three companies being removed as well as a "desire to diversify the sector and industry group representation of the index."
Diversification is a worthwhile goal, but the index committee missed an opportunity to add a giant company with huge annual sales whose business is much more representative of the American economy than any of three companies added.
That company is Berkshire Hathaway ( BRKA brka -0.12210136968105488% Berkshire Hathaway Inc. Cl A U.S.: NYSE USD195500 -239 -0.12210136968105488% /Date(1443819709642-0500)/ Volume (Delayed 15m) : 312 P/E Ratio 17.894654780576246 Market Cap 320691521185.372 Dividend Yield N/A Rev. per Employee 631234 More quote details and news » ) ( BRKB ). Berkshire had sales of $162 billion last year and has a market value of $277 billion, fourth in the stock market behind Apple, ExxonMobil and Google.
Most of Berkshire's sales are domestic, and it's exposed to a wide swath of the economy with ownership of the Burlington Northern and a slew of industrial and financial businesses. Berkshire's class B shares, now trading at around $113, could have been added to the Dow. An addition of Berkshire to the Dow industrial would have been a crowning achievement for CEO Warren Buffett, who took control of the company in 1965 when its market value was around $30 million.
The index committee also passed on adding Google and Apple to the Dow. That probably would have required a tweak to the current Dow structure, which weights each of the 30 members by their stock prices. With Google at $887 and Apple at $500, either would have overwhelmed the index. What the index committee could have done – but evidently chose not to do -- was put in either company based on a fractional share. Apple could have been added at a quarter of its stock price, or roughly $125 currently.
Other large and worthy companies that were passed up were Oracle and Ford Motor. Ford's revival would have made it a nice addition to the Dow, a replacement for General Motors, which was dumped in 2009 on its way to bankruptcy. Ford has many domestic factories, employs thousands of workers in the U.S. and makes most of its profits domestically. One problem with Ford, which has a market value of $70 billion, is its low stock price of $17.
Alcoa and Bank of America, which are being booted from the Dow, were recently trading at $8.09 and $14.69, respectively.
The addition of Goldman and Visa will give those two companies disproportionate influence in the Dow thanks to their high stock prices. Goldman, at $163, and Visa, at $183, will have weightings of 7.7% and 6.9%, respectively, according to Birinyi Associates. Visa and Goldman will be No. 2 and No. 3 in importance, just behind IBM, which has a share price of $187. Goldman and Visa will have outsized influence relative to their market values. For perspective, Goldman, with a market value of $75 billion, will shockingly have about five times the weight of Microsoft, which has triple Goldman's market value.
Such is the quirk – and arguably the problem – of the Dow industrials. With the index changes, which will take effect on Sept. 23, five stocks will account for a third of index: IBM, Visa, Goldman, Chevron and 3M. Four large companies with sizable market values, Pfizer, Cisco Systems, General Electric and Intel, have a combined weighting of less than 5% -- under that of Goldman – thanks to the Dow's price weighting.
Goldman is an odd choice because it's not a traditional financial company that focuses on lending money. It makes most of its profits from trading and its outlook hinges on things like regulatory actions like the Volcker rule. Visa essentially is a toll taker on global financial transactions.
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By this call, the United Nations Capital Development Fund (UNCDF) invites project developers to submit investment proposals under the Local Finance Initiative Uganda programme (LFI-U) which is being implemented in partnership with the Government of Uganda through the Ministry of Local Government (MoLG).
General Context
Digital technology, regulatory changes and increased public and private sector engagement are fuelling a renewed push to reduce the number of unbanked and underbanked people in the Asia Pacific region. However much more needs to be done to ensure these efforts have the impact and scale to make a significant difference.
Mobile Money for the Poor (MM4P), un programme de l'UNCDF (United Nations Capital Development Fund) organise ce mardi 6 octobre à Cotonou un atelier pour le lancement officiel de son programme au Bénin, en présence de l'ensemble des acteurs de la finance digitale.
The Sustainable Development Goals represent a transformative agenda. The objective is to transform the economies and societies of developing countries with a view to eliminating poverty by 2030.
Today, 2 billion people lack access to formal financial services. This represents a pool of customers with the potential to save US$145bn a year. This global challenge requires global solutions. Financial inclusion – starting with supporting people to save – can enable poverty reduction, social equality and the economic growth of the next generation.
The UN Sustainable Development Goals Fund (SDG Fund), the Sino-American Friendship Association (SAFA), in partnership with the China Women Development Foundation (CWDF), hosted the summit entitled "2015 Empowering Women and Sustainable Development Summit". The event was significant since it is 20 years since the Beijing Call for Action.
WHAT: In the context of the UN Sustainable Development Summit 2015, United Cities and Local Governments (UCLG), the Government of Uganda and the United Nations Capital Development Fund (UNCDF) cordially invite you to a side event on the topic: No Transformation Without Localization: The role of local governments in the effective implementation of the Sustainable Development Goals.
The side event has three main objectives:
The Reserve Bank of Fiji and the Pacific Financial Inclusion Programme jointly launched the Fiji Financial Services Demand Side Survey report at the Grand Pacific Hotel in Suva.
The Fiji report is aimed to help government and other stakeholders gain better understanding of the needs of Fijians in regard to financial services and products by providing baseline data on access, usage and quality of the financial services and products currently available to all Fijians from the viewpoint of the customer.
United Nations Capital Development fund (UNCDF) Executive Secretary Ms. Judith Karl met with students and teachers of Nuku Primary School on Wednesday as part of her four-day visit to Fiji.
Nuku Primary school is recognized for its excellent integration of financial education (FinEd) in classroom setting and delivering FinEd in a practical manner to students from low-income families within a rural setting. Despite resource constraints, the school offers both early childhood learning together with FinEd from Years 1 through to 8.
UNCDF and the Commonwealth Local Government Forum (CLGF), based in Fiji, conducted a scoping mission from August 27 - September 10 in Tuvalu for the design of the LoCAL mechanism. Tuvalu is the first country in the Pacific where the LoCAL mechanism will be designed.


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"It's cool because the band grew within this one bar. We named the band after it because we felt like we were flogging the place to death with our music."
"It is strange being the young one, but it is great because I grew up watching these guys and now I get to meet them and work with them,"


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Aimed at beginners at sewing, the Brother JS23 sewing machine has 14 stitch options and a 4-step buttonhole facility. It also features a front-loading bobbin and forward and reverse sewing modes, and can be used in embroidery.
Catalogue Number: 100-2696
- Forward & reverse sewing modes
- Embroidery options
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Page 1
Neuroscience in the era of functional genomics and systems
Daniel H. Geschwind1,2 and Genevieve Konopka1
1Program in Neurogenetics and Neurobehavioural Genetics, Department of Neurology and Semel
Institute, David Geffen School of Medicine, Los Angeles, California 90095, USA
2Department of Human Genetics, David Geffen School of Medicine, Los Angeles, California
Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-
generating, research that provides a powerful complement to the more directly hypothesis-driven
molecular, cellular and systems neuroscience. Genetic and functional genomic studies have
already yielded important insights into neuronal diversity and function, as well as disease. One of
the most exciting and challenging frontiers in neuroscience involves harnessing the power of
large-scale genetic, genomic and phenotypic data sets, and the development of tools for data
integration and mining. Methods for network analysis and systems biology offer the promise of
integrating these multiple levels of data, connecting molecular pathways to nervous system
The molecular biology revolution allowed neuroscientists to move from the study of circuits
and systems to the detailed study of individual molecules of interest. However, moving from
genes to an understanding of interacting signalling or metabolic pathways within cells, let
alone combining these data to achieve a systems-level understanding of brain circuit
function in health and disease, poses enormous challenges. The integration of data across a
wide range of observations is especially important in neurobiology. In contrast to the
physical sciences, the biological sciences have few guiding theories or laws (with the
exception of evolution) with which to direct and prioritize investigations. At the same time,
we are in the midst of a genomic and informatics revolution that permits us to view specific
gene products in the context of all others. The adoption of functional genomic or molecular-
systems methods that permit dynamic measurement of gene products in a highly parallel
manner, coupled with an underlying systems-level knowledge of the organization of these
gene products, has the potential to provide a more integrative understanding of nervous
system function.
The field of neuroscience has been slow to adopt functional genomic and genetic methods
and the large-scale databases and resources that ideally result from their use. For example,
neuroscience has consistently lagged behind cancer biology in the adoption of new
molecular and genetic methods, starting with molecular cloning and continuing to functional
genomics and genetics today. There are legitimate reasons for this, including the extreme
© 2009 Macmillan Publishers Limited. All rights reserved
Correspondence should be addressed to D.H.G. (firstname.lastname@example.com).
Reprints and permissions information is available at www.nature.com/reprints.
The authors declare competing financial interests: details accompany the full-text HTML version of the paper at www.nature.com/
NIH Public Access
Author Manuscript
Nature. Author manuscript; available in PMC 2013 May 06.
Published in final edited form as:
Nature. 2009 October 15; 461(7266): 908–915. doi:10.1038/nature08537.
NIH-PA Author Manuscript
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NIH-PA Author Manuscript
Page 2
cellular heterogeneity and complexity of neural circuits relative to most non-neural tissues,
and the reliance on post-mortem materials for most human studies1–4. Another obstacle is
the generation of enormous amounts of data. Similarly to what occurred in the field of
genetics, clusters of computationally oriented researchers have to form within or around the
laboratories more concentrated on the '-ology' fields ('ologies'). This integration of
computational biology or bioinformatics in modern neuroscience laboratories or groupings
will become even more critical as more powerful technologies that generate many orders of
magnitude more data, such as next-generation sequencing techniques, replace microarrays.
An additional, sometimes unspoken, impediment to the more widespread adoption of '-
omics' fields ('omics') in neuroscience research is an underlying tension between the
hypothesis-testing approach applied in the typical neurobiology laboratory and the
discovery-based disciplines of genetics, genomics and proteomics (Box 1).
Box 1
In search of hypotheses
The reluctance of neurobiologists to adopt omics approaches has many roots, including
the often-stated aversion to 'fishing expeditions' without clearly defined hypotheses. Yet
omics, or discovery-based, approaches do not eschew hypotheses; rather, they seek to
elevate hypothesis testing to a new level, by allowing high-throughput hypothesis
generation and prioritization. It is also notable that although functional genomics has led
to a revolution in the field of cancer research, it has taken much longer to appeal to
neuroscientists. Discovery-based research appears to be of more interest in disease-based
fields, because the focus is on generating novel hypotheses and discovering new
therapeutic and diagnostic approaches. It is only over the past two decades that disease-
focused research has gradually evolved to become a considerable force in neuroscience.
A corollary of this comparison is that, in general, the field of modern cancer research has
been much more successful in developing new therapeutic techniques that have
subsequently been translated into clinical practice71. There are many reasons for this,
including access to tissue. However, advances in cancer research have also been
catalysed by the core omics methods, which have not yet been as widely applied in
disease-related neuroscience. The prediction is that a wider application of omics methods
to neurological and psychiatric diseases14,16 in both model systems and patients will
significantly accelerate advances in therapeutic development in neuroscience. One area in
which this appears promising is in the detection of disease biomarkers (see page 916)
based on transcriptional profiles12,13,72,73. Because brain tissue at the appropriate
developmental or disease stages in humans is rarely available, molecular biomarkers do
pose a particular challenge. The use of peripheral tissues, such as blood, lymphoblasts or
fibroblast-derived induced pluripotent stem cells, by omics methods provides a potential
solution. Published data suggest that peripheral gene expression profiles might reflect
aetiological subtypes of disease on which to stratify patients for genetic studies of
complex neurologic or psychiatric disorders69–71, in a loose parallel with the tissue-
biopsy approach central to the cancer field.
The revolutionary nature of these genomic advances and the rapidly evolving technologies
that continue to further the high-throughput omics agenda clearly distinguish this form of
research from the more hypothesis-driven work performed in most neurobiology
laboratories. Omics research requires not only large-scale instrumentation and multi-
disciplinary teams of biologists, computer scientists, mathematicians and statisticians, but
also a fundamental change in perspective5. The omics view is that an understanding of the
organization and structure of the genome and the high-throughput measurements of the
relationships of its elements, or gene products, provides a systematic basis on which to
Geschwind and Konopka
Page 2
Nature. Author manuscript; available in PMC 2013 May 06.
NIH-PA Author Manuscript
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Page 3
understand biological processes. Furthermore, significant value is placed on resource
building and data sharing. Omics is not exclusive of more standard methods, and in fact is
ultimately at its most powerful when combined with careful experimental validation. From
this vantage point, the potential for discovery through large-scale screening and analysis
provided by omics contrasts with the ability to incrementally advance science through
individual hypothesis testing, one gene at a time.
The power of functional genomics in neuroscience is highlighted by several successful
demonstrations of the strength of such methods to identify the molecular basis of neuronal
diversity6–10, synaptogenesis11, disease biomarkers12,13, disease mechanisms and
pathways13–16 and the development of user-friendly genome-scale resources17,18. These
projects, along with other early proofs of principle19,20, have clearly weakened the notion of
the superiority of research based on single-hypothesis testing over hypothesis generation and
prioritization using omics-based or discovery-based methods as a starting point. These
approaches, which provide a new framework for the rapidly growing fields of neurogenetics,
neurogenomics and systems biology, and the challenges that accompany them, are the
subject of this Review. We discuss the value of data sharing and provide some key examples
of neuroinformatics-based or omics-based resources, highlighting areas in which genetic and
functional genomic approaches have brought new biological insight to different areas of
neuroscience. We conclude with a discussion of the new frontiers in biological networks and
systems biology.
Public data sharing and resource generation
Omics data provide a platform for small-scale and large-scale in silico discovery and
hypothesis generation that often goes beyond the scope of the original experiment. This
notion supports the proposition that data from microarray studies have most value in the
public domain, where they can be mined or combined with other studies21. However,
proteomic and transcriptomic data are inherently less generic than sequence data, so
obstacles such as variable sample preparation, experimental annotation and platform
differences prevent a single fully unified data resource. The development of a framework,
MIAME (minimal information about a microarray experiment), allowed the creation of
centralized repositories for these data created on multiple platforms in laboratories around
the world (Box 2). A growing number of studies that have capitalized on such databases,
including those cited above and others22–27, have demonstrated that the widespread
availability of these proteomic and transcriptomic data are of great benefit. One caveat with
any resource based on compilation from multiple sources is that the data are only as good as
the experimental and sample phenotype annotation. As microarray-based hybridization
platforms for expression analysis give way to sequencing-based approaches, these data will
become more generic, diminishing, but not eliminating, cross-platform compatibility issues.
Box 2
Major public databases
The Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo), supported by
the US National Institutes of Health, is the most widely used open-access repository for
storing and uploading unfiltered, unmanipulated microarray and sequencing data.
ArrayExpress (http://www.ebi.ac.uk/microarray-as/ae), housed at the European
Bioinformatics Institute, is the other major public repository of microarray data. A large
non-public repository of microarray data is the Stanford Microarray Database (http://
smd.stanford.edu). Investigators can easily access archived data and implement their
analyses on these data sets, allowing continued analysis of any deposited data set using
future methodologies. The ability to query several parameters from a vast number of
Geschwind and Konopka
Page 3
Nature. Author manuscript; available in PMC 2013 May 06.
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deposited samples across many species and tissues should allow for the development of
interconnected data sets at multiple expression levels to build a wider view of expression
in a given species and between species. The Celsius database (http://
celsius.genomics.ctrl.ucla.edu) is one such attempt, and combines nearly 100,000
publicly available Affymetrix microarray data sets for global analysis of particular gene
co-expression patterns74. ArrayExpress provides a portal through which to query highly
annotated meta-summary data from approximately 1,000 microarray experiments and
nearly 30,000 microarrays. Similarly valuable proteomic and protein-interaction
databases exist75–78, including lab-based systems such as the Organelle Map Database79
(http://18.104.22.168/ormd/), which organizes 1,405 proteins into ten specific organelles
on the basis of correlation profiling. Considerable work is going into centralizing and
curating proteomics data; databases include Peptide Atlas (http://www.peptideatlas.org)
and The Human Proteinpedia80 (http://www.humanproteinpedia.org), which involves the
efforts of over 70 laboratories and provides the most integrated, searchable portal to
many data types from diverse platforms, ranging from cytochemistry to mass
In parallel with the growth of generic data repositories, standardized resources built by
coupling high-throughput analyses with bioinformatics tools provide a clear demonstration
of the value of large-scale omics data. The development of such resources requires
significant foresight, planning and investment, but their worth is unquestionable if they are
properly managed. Additionally, just as for DNA sequences and the genome databases,
errors exist. Quality control must be balanced with throughput. Ideally, such resources
would provide access for users to post corrective data or suggest annotations that would
enhance the accuracy of the resource in real time.
Use of these resources to reanalyse public data is often a necessary feature of the well-
rounded systems biology approach, raising the issue of the primacy of data analysis versus
data generation. There is a clear tension between biological advances obtained in this way
and the generation of new data, the latter usually carrying more weight in terms of novelty
and degree of difficulty. Often, data analysis is not considered to be as much of an advance
as the generation of new data, no matter how narrow the new data may be. However, a new
perspective must be adopted to take into account studies that analyse data generated by
others or in the public domain, to lead to new levels of understanding, or provide database
tools around these data, even if no 'new biology' is done. The notion of what constitutes an
experiment must expand to include analysis only, in addition to standard bench work.
Similarly, we need to ensure that the next generation of neuroscientists has the quantitative
skills to allow them to take full advantage of these opportunities. Here we highlight a few
examples of advances based either on the generation of new omics data resources or on the
analysis of data from such resources to provide fresh biological insights.
Surveying the nervous system transcriptome
Knowledge of the spatial and temporal expression of every gene in the nervous system is a
natural, neuroscience-specific extension of the human genome project. Thus, a number of
different approaches have been undertaken to identify neuroanatomical patterns of
expression on a global scale. The most complete gene expression resource for
neuroscientists is the Allen Brain Atlas (ABA; http://www.brain-map.org), which is a
neuroanatomical repository of gene expression information in both mouse and human brain.
Using high-throughput, standardized in situ hybridization to display messenger RNA
expression in a given section of brain tissue, the Allen Institute for Brain Science has
generated an interactive guide into the entire known brain transcriptome. Users can query
the maps by gene or brain structure and generate three-dimensional overlays of any
Geschwind and Konopka
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Nature. Author manuscript; available in PMC 2013 May 06.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 5
permutation of gene and structure. Such a tool can be useful in determining the
developmental and regional specificity of a particular gene, as well as the combinatorial
expression of groups of genes. GenePaint (http://www.genepaint.org) and the Brain Gene
Expression Map (BGEM; http://www.stjudebgem.org) are two other databases of mouse
gene expression based on in situ hybridization at various developmental stages. Both contain
more embryonic data than the ABA, but they are more limited in scope and do not reference
a three-dimensional atlas.
The first project involving the Allen Institute focused on adult mouse brain in one strain
(C57BL/6J)18, but since then its research has expanded to encompass a variety of adult and
developing mouse data sets and will soon also contain a first-generation data set from adult
human brain. Additional data-mining tools that take advantage of the digital nature of the
data include the Anatomic Gene Expression Atlas, which integrates all of the data from the
ABA and the Allen Reference Atlas to build three-dimensional maps of correlated gene
expression patterns. For example, this level of analysis permits the querying of different
cortical layers and laminar gene expression to find clusters of co-expressed genes.
These tools have been used28 to study hippocampal molecular anatomy, further subdividing
the CA3 region of the hippocampus into nine distinct regions, each with its own genomic
signature presumably underlying different functionalities. Using both computational and
manual methods of analysis, the hippocampus was recurrently subdivided into smaller
subsections based on overlapping patterns of gene expression. This subdivision allowed the
generation of novel three-dimensional modelling of the hippocampus, as well as functional
analysis of gene expression within a given subsection. The validity of the approach was
confirmed using a combination of retrograde labelling and in situ hybridization. Thus, using
the publicly available ABA, this study verified that hippocampal circuitry is driven, at least
in part, by regional gene expression. These findings are critical for future experiments
examining hippocampal function in targeted transgenic model systems.
The Gene Expression Nervous System Atlas (GENSAT; http://www.gensat.org) is a
multifaceted resource that includes a public database of gene expression in the central
nervous system of both the developing mouse and the adult mouse, based on bacterial
artificial chromosome (BAC)-transgenic reporter mice29. These mice, which are publicly
available, provide unique, high-spatial-resolution information on the morphological pattern
of expression of specific genes in vivo. The genetic labelling of individual and specific
neuronal populations has implications for a wide range of investigations in fields from
physiology30 to functional genomics9. For example, such techniques can be used to purify
neurons, in combination with other approaches such as retrograde injections, fluorescence-
activated cell sorting, manual dissections or immunopanning, to uncover cell-class-specific
neuronal gene expression profiles6,7,9,10.
On a related theme, the recently developed 'bacTRAP' technology uses BAC-transgenic
mice with green fluorescent protein fused to a ribosomal protein under the direction of a
specific cell-type promoter to permit translating-ribosome affinity purification (TRAP)8. All
mRNAs in the process of translation, which are thus attached to ribosomes, can be isolated
from a specific cell type by using an antibody against green fluorescent protein. This
approach avoids the potential for stress-induced or injury-induced changes in gene
expression and is amenable to high-throughput analysis, once the mice are grown. An
impressive 24 lines of bacTRAP mice generated deep expression profiles31, providing
thousands of new markers and cell-specific targets for further investigation. Future studies
will be needed to validate this approach and determine its improvement over the other well-
studied methods mentioned above. All of these investigations of purified neuronal or glial
Geschwind and Konopka
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text:
Air Mobile Ministries
Rating: 2 stars 1 1 review 1,098
Nonprofit Issues:
Human Services, International, Economic Development, Microfinance
8850 Grissom Parkway Titusville FL 32780 USA
Provides portable water purification and filtrations systems to remote areas, villages and cities that have been received extensive disaster damage where polluted water exists.
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Skydive AtlantaRead MoreSkydive Atlanta is certified by the U.S. Department of Defense, as they are the training home for the Silver Wings, a U.S. Army parachute team. Here's what that means for civilians thinking of taking the plunge: this skydiving outfit is routinely inspected by the Department of Defense, and equips its divers with state of the art equipment such as the "T-Strap", a harness that adds yet another level of safety to the operation. For more than 28 years, the team here has been curating safe and exciting airborne plunges, including tandem skydives led by certified pilots and instructors. After a class led by a USPA-certified instructor, divers take to the skies and leap while strapped to a professional, free-falling at speeds of up to 120 miles per hour before opening the parachute and floating gracefully to the ground or nearest pile of pillows. Skydive Atlanta also offers DVD and photo options that commemorate skydivers' daring journey through the air.2333 Delray RoadThomaston, GA US
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Blockbuster releases are homogenising around a narrow range of experiences and it could be driving creative people out of the industry
Ubisoft boss Yves Guillemot refuses to rule out long-awaited sequel and suggests that game designer Michel Ancel is involved
The controversial murder spree shooter is a monochrome menace to the legacy of glorious twin-stick shooters like Robotron
EA Sports has spent development time making its Fifa games more inclusive and representational – predictably, there has been an online backlash
Hatred: gaming's most contrived controversyKeith StuartSoon-to-be-released Hatred has already garnered column inches and been banned from streaming service Twitch. Not bad for a schlock-horror cliche
I wasn't expecting a young, vibrant creative world to have a uniform. But there is an insidious pressure to fit in, and it involves plaid and denim
Psychologist Philip Zimbardo suggests that boys are increasingly withdrawing into the lonely world of gaming. But this is an outdated view of the medium
Double Fine has released the second part of its successfully crowdfunded point-and-click epic, but the road to release has not been easy
Jack Attridge, widely seen as Peter Molyneux's protege, is parting ways with 22Cans to work on his own projects. He talks exclusively to the Guardian about his decision
I'm spoiled for choice when it comes to digital crushes, but there's little out there for my boyfriend – and that makes games worse for him
A recent letter from a group of headteachers claimed that allowing children to play some types of video game effectively constitutes parental neglect. But what is the scientific evidence for such claims?
The latest title in the multimillion selling shooter series swaps soldiers and terrorists for cops and robbers. But is the fantasy now too close for comfort?
The latest Ubisoft action adventure locked certain content unless players downloaded a special app. The feature has been abandoned but it says a lot about where games are
In 2004, the EA Spouse controversy exposed a culture of unpaid overtime throughout the games industry. In this special report we investigate how much, if anything, has changed
The veteran game designer is at the centre of a raging controversy over his new game Godus. In this exclusive interview, he says that his relationship with the press is over
Anita Sarkeesian has announced a new video series looking into masculinity and video games. The hate has already started, but it is misplaced
The controversial 'mass-murder' game has been restored to the community voting area of the major digital games store
The controversial mass-murder simulator has been taken off the leading games distribution site, despite attracting thousands of positive votes
Three weeks after launch, the online functionality behind one of PlayStation 4's biggest releases is still down – and the players are angry. By Joao Diniz Sanches


text:
[This message edited by gonnabe2016 at 2:47 AM, April 15th (Tuesday)]
In my effort to be *concise*, I often come off as blunt and harsh. Sorry, don't mean to be offensive.
Don't make anyone a priority when you are only an option.
* Still washing my own dishes like a chump - no dish-robots yet.
* Megan Draper is still alive
* Florida is NOT under water
Thank God for that!!!!
I can't swim!
Think of the haters in your life as sandpaper; theyll scratch you up time and time again but in the end youre polished, smooth, and spotless..while they end up useless
We make a living by what we get, but we make a life by what we give.
[This message edited by Jrazz at 1:02 AM, May 20th (Tuesday)]
Did I scare y'all?


text:
Walters Equipment is a full-service outdoor power equipment dealer offering sales, service, parts, and rental to contractors and homeowners in Byron Center, MI and the surrounding SW Grand Rapids area. Walters is a factory authorized dealer for Husqvarna, Simplicity, Ferris, Little Wonder, and Vortex. We are also a factory authorized warranty dealer for Briggs & Stratton, Kohler, Kawasaki, Honda Engines, MTD, and Troybilt.We ship OEM parts across the country with fast turnaround and great shipping rates! Use our free parts finder tool to find the parts you need or browse our fast moving parts catalogs.
Store Hours: Mon-Fri 7:30am to 5:30pm and Saturday 8am to 5pm
- All Brands


text:
M. Night Shyamalan Blackout Falls on 'After Earth'
It's been a rocky road for M. Night Shyamalan, who hit a career high in 1999 with the eerie Oscar-nominated thriller "The Sixth Sense," but in recent years has struggled to stay atop Hollywood's A-list of directors after several box office misses. Yet, ever since "Sixth Sense's" surprise blockbuster success, the writer-director has been the marquee selling point for each of his films — until now.
With Sony's post-apocalyptic "After Earth" set for release May 31, the studio opted to put stars Will Smith and his teenage son Jaden front and center in the marketing campaign for its $100 million-plus family picture, pushing Shyamalan out of the spotlight.
M. Night Shyamalan's Box Office Track Record:
M. Night Shyamalan has never been able to duplicate the success he achieved with "The Sixth Sense." Here are the worldwide grosses for his films:
Nowhere in the key promotional materials — the posters, trailers, TV spots and the film's own website — is there a mention of the director. (You have to read the fine print in the credits to see his name.)
"Night is, without a doubt, a world-class filmmaker who we were thrilled to team up with on this project," says Jeff Blake, Sony's marketing and distribution chief. "Together, we decided to focus our campaign on both the action and Will and Jaden, given that "After Earth" is an adventure story of a father and son."
Tracking for the film's opening has picked up lately, with expectations of a $35 million-$40 million debut. That said, the marketplace is crowded with tentpoles, including newcomer "Star Trek Into Darkness," which bowed May 16, and Memorial Day weekend pictures "The Hangover Part III" and "Fast and Furious 6."
Shyamalan's once-hot brand name means less to audiences today than it did before, given a string of disappointments, including his most recent effort, Paramount's 2010 release "The Last Airbender."
Despite his lack of visibility in "After Earth's" marketing, surprisingly more than 60% of the approximately 1,000 moviegoers polled by Fandango in a proprietary survey conducted for Variety said they were aware that Shyamalan was directing the picture.
However only 39% said that fact made them more excited to see it. And on Facebook and Twitter, Shyamalan registers even less strongly, driving just 2% of the online chatter on "After Earth," as opposed to Smith and son, who are the subject of a dominating 32% of the conversation — the vast majority of which is positive, according to social-media listening firm Fizziology.


text:
Free, online book for educators and high-school students looking to go beyond the standard courses
6 Jul 2009
Experiments with MATLAB is a free, online book for educators and high school students looking for material that goes beyond their standard courses. College students early in their careers will also find value in the materials and exercises.
By Cleve Moler, The MathWorks


text:
A growing number of shops in Nice are peddling a variety of blameless products, such as the organic cosmetics (Weleda, Dr Hauschka and the rest) that are...9 Bis rue Colonna d'Istria
What 21st-century city can really feel complete until it has a spa? Fortunately for Nice, this stylish retreat ensures its citizenry don't ever get too...37 rue Masséna
The famous perfumer from nearby Grasse keeps the citizens of Nice smelling nice through this fragrant and attractive boutique. All kinds of bottled scents...20 rue Saint François de Paule


text:
Pierre & Vacances Résidence Les Rives de la Seugne
- Swimming pool
- Sauna
- Free parking
Main amenities
- 72 guestrooms
- WiFi in the lobby
- Garden
- Self-serve laundry
- Multilingual staff
- Luggage storage
- Limited hour front desk
- Playground
What's around
- Les Antilles de Jonzac (0.1 mi / 0.2 km)
- Chateau de Plassac (9.2 mi / 14.8 km)
- Church of Our Lady of the Assumption (10.9 mi / 17.6 km)
- Church of Saint-Palais-de-Phiolin (12.1 mi / 19.5 km)
Enter dates to check prices
Hotel Info: 01 65 69 441from €89
- Studio 4-5
- Condo, 1 Bedroom
- Condo, 2 Bedrooms
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 72 rooms
- Check-in time 5 PM-7 PM
- Check-out time is 10 AM
Required at check in
- Credit card deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed *
- WiFi in public areas *
- WiFi in rooms *
- Free self parking (limited)
Nearby Three Star Jonzac hotels
In the hotel
- Playground on site
- Bicycle rentals nearby
- Golf lessons available nearby
- Golfing nearby
- Front desk (limited hours)
- Laundry facilities
- Luggage storage
- Number of buildings/towers - 4
- Garden
In the room
- Coffee/tea maker
- Iron/ironing board (on request)
- Blackout drapes/curtains
- Furnished balcony or patio
- Private bathroom
- Bathtub or shower
- Free toiletries
- Hair dryer (on request)
- Flat-screen TV
- WiFi (surcharge)
- Refrigerator
- Microwave
- Kitchenette
- Stovetop
- Cookware, dishware, and utensils
- Dishwasher
- Housekeeping - once per stay
Top Jonzac hotels
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"Ideal budget hotel for short stay such as ours. Room was smaller than similar priced hotels but did have the advantage of having an en-suite wet room with shower. Breakfast was an…"Jul 17, 2015
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"Very convenient location, just off the motorway. Stayed as on overnight on our way back to the ferry. Very friendly staff and a great evening meal."Jul 13, 2015
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Pierre & Vacances Résidence Les Rives de la Seugne's small print
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 1.50 per person, per night. This tax does not apply to children under 13 years of age.
Deposit: EUR 200.00
Optional extras
Late check-out can be arranged for an extra charge
Cribs/Infant beds are available for EUR 40 per stay
Pets are allowed for an extra charge of EUR 9 per pet, per day
WiFi is available in guestrooms for EUR 5 per day (rates may vary)
WiFi is available in public areas for EUR 5 per day (rates may vary)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
Yeah, I'm with you on that Carter. My time is up too. The only time I've even checked PSD since the league ended was to see Cubs/Joe Maddon news.
It's been a good run yall.
Type: Posts; User: BullsNumber1Fan
Yeah, I'm with you on that Carter. My time is up too. The only time I've even checked PSD since the league ended was to see Cubs/Joe Maddon news.
It's been a good run yall.
Team Choice- No Preference
First/Last Name - BN1F
Date of Birth - 06/29/1969
City - Chicago
State - IL
College - Loyola University Chicago
Caris LeVert
Shooting Camp - 4 Jump-shot, 4 3pt
Strength - 4 Strength, 10 pounds
Wayne Selden
Shooting Camp - 4 Jump-shot, 4 3pt
Combo Camp - 3 Quickness, 3 Jumping
Pace: Fast
Press: Normal
Trap: Normal
Offense: Balanced
I'm fine with him doing the whole season in 1 sim. Think it'd be a good way to end this sim instead of stopping mid offseason.
Pretty much this. Unless d1 wanted to do 2 60-day sims and then the playoffs just to finish this last season. It'll be easy and quick.
The whole league is inflated C2H. Gerald Wilkins would have been one of the best wing players in the sim if this was the beginning. And so would Bradley Beal.
We'll see;)
But yeah, maybe keeping 2 or 3 camps is fine, but we should definitely drop both the Euro and DLeague IMO. When has a top draft pick ever missed any time in a season? I'd be fine...
Maybe rigging wasn't the right word. I'm not trying to accuse any of the commishes of rigging. But I just remember Matter saying he gave the GM's he liked more things in camps. Just little stuff...
I'm not 100% sure I'll be in the next restart, but I would love a league with no camps, euros, and DLeague. Keep it more true and just let the game play itself out. And there would be a lot less...
Cut Avery Bradley injury please
- $4,000,000
The only thing I really have to say is that ORTG is quite possibly the worst offensive stat you can use. It's mainly just a team stat.
Pau last season averaged 17/10/3.5 with a 52.5 TS% and a...
So it's still 7-6 with Des Plaines leading with both votes switched.
I think you accidentally clicked Seaside then lol
Previous Cash Total = $115,527,494
Camp Checker: + $20,000,000
Camps: - $25,000,000
New Cash Total = $110,527,494
Karl Towns
Post Camp - 2 Blocking, 3 Post D, 3 Drive D
Strength - 4 Strength, 10 pounds
Caris LeVert
Combo Camp - 3 Quickness, 3 Jumping
Wayne Selden
Speed - 6 Quickness
Any 2 undrafted rookies (or however many I need to get to 12)
Atlanta Hawks
C: Enes Kanter | Karl Towns | Enes Kanter
PF: Nikola Mirotic | Karl Towns | Nikola Mirotic
SF: Caris LeVert | Danny Granger | Danny Granger
SG: Ty Lawson | Wayne Selden | Wayne...
Not even close. Phlp and I had the 1 seed last redraft and we lost in the 1st ****ing round to a trash team that wouldn't even score 75 PPG...
Danny Granger on the MLE? Awesome!
He wrote that last night.:laugh2:
So yes, it's tonight.
Nah you didn't Tym. It's tonight.
Nene has never had a problem defensively and Pau is a 7 foot rim protector. They would do just fine defensively.
And sharing the ball won't be a problem at all when you have a championship PG...
Which is more of what I'm talking about. It's easy to break down a defense that is already broken down already by TP/Rudy. And the same goes for TP/Rudy if Oladipo were to break it down.
It was more of a joke. Wasn't really trying to compare or else I would have wrote more than I did and explained it.:laugh2:
But I wasn't trying to compare Victor to Manu and Gay to Kawhi.
The same way that Parker-Manu-Kawhi worked for the Spurs.


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- Cell signalling
Cell signalling
This unit explains the general principles of signal transduction and specifically, how...
This unit explains the general principles of signal transduction and specifically, how even the simplest organisms can detect and respond to events in their ever-changing environment.
By the end of this unit you should be able to:
- define and use each of the terms printed in bold in the text.
- understand the basic principles of signal transduction mechanisms, in particular the concepts of response specificity, signal amplitude and duration, signal integration and intracellular location;
- give examples of different types of extracellular signals and receptors, and explain their functional significance;
- describe the mechanisms by which different receptors may be activated by their respective ligands;
- describe and give examples of the structure and properties of the major components of signal transduction pathways;
- understand and give examples of the role of protein binding domains in the specific interactions between signalling molecules;
- understand and give examples of how signalling pathways triggered by different ligands are integrated within a cell to give a specific functional response.
- Duration 12 hours
- Updated Monday 8th July 2013
- Advanced level
- Posted under Science, Maths & Technology
- Current section: Introduction
- Learning outcomes
- 1 General principles of signal transduction
- 1.1 Introduction
- 1.2 Extracellular signals can act locally or at a distance
- 1.3 Most receptors are on the cell surface
- 1.4 Cellular responses are diverse
- 1.5 Signal transduction mechanisms
- 1.6 Signalling proteins can act as molecular switches
- 1.7 Localization of signalling proteins
- 1.8 Protein–protein interactions in signal transduction
- 1.9 Summary
- 2 Receptors and their ligands
- 3 Intracellular signalling components
- 3.1 Introduction
- 3.2 Trimeric G proteins
- 3.3 Lipid-modifying enzymes
- 3.4 Second messengers
- 3.5 Monomeric G proteins
- 3.6 Protein kinases
- 3.7 Protein phosphatases
- 3.8 Activation of transcription factors
- 3.9 Summary
- 4 Glucose metabolism: an example of integration of signalling pathways
- Next steps
- References
- Acknowledgements
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Cell signalling
Even the simplest organisms can detect and respond to events in their ever-changing environment. Similarly, within a multicellular organism, cells are surrounded by an extracellular environment from which signals are received and responded to. Extracellular events are decoded and transmitted to relevant parts of individual cells by way of a series of activation/deactivation steps involving many intracellular molecules. This relay of information along molecular pathways is called signal transduction; it is sometimes also simply referred to as 'signalling'.
The molecular models shown in this chapter were produced using the Brookhaven protein data base (pdb) files indicated in the figure legends. These files can be downloaded, viewed and manipulated using a suitable molecular viewing programme, such as Viewerlite tm.
This unit is an adapted extract from the Open University course S377 Molecular and cell biology [Tip: hold Ctrl and click a link to open it in a new tab. (Hide tip)] .
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Originally published: Monday, 8th July 2013
Last updated on: Monday, 8th July 2013
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C.J. Cron, the Angels' top pick (17th overall) in the 2011 Draft, left in the first frame of short-season Orem's 3-2 home victory over Ogden in 11 innings with a knee injury. The cleanup hitter had been on a tear lately with six homers and 17 RBIs in the previous seven games.
Cron later said on Twitter that he had suffered a dislocated kneecap.
Already affected by a torn labrum in his right shoulder, Cron was injured Sunday in the middle of his first at-bat. Normally a first baseman, he has not played the field this season, instead serving as Orem's designated hitter.
With two outs and Jerod Yakubik on third base, Cron hit a foul ball and went down to the ground immediately. According to Ogden broadcaster Brandon Hart, it took seven people to get the 6-foot-4, 235-pound Cron onto a stretcher before he was placed in an ambulance.
The former University of Utah standout was replaced by pinch-hitter Andrew Ray, whose swinging strikeout was credited to Cron.
Cron leads the Pioneer League with 13 homers and 41 RBIs.
The 21-year-old will meet with the team doctor Monday, and Orem's plan of action will be determined based on that examination.
The Owlz scored a run in the bottom of the 11th to end the bittersweet day. Ogden's Matt Shelton (2-1) hit Trevor Hairgrove to open the inning, and Hairgrove advanced on groundouts by Gary Mitchell and Drew Martinez. Brandon Brewer then hit a walk-off single.
Today on MiLB.com
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- Org All-Stars: Braves find diamonds in rough


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Seriously funny, but mostly sad, Yelp reviews of Yosemite
Some times you have to wonder about what people were expecting when they came to Yosemite.
Some times you have to wonder about what people were expecting when they came to Yosemite.
Crane Flat Campground is closed through Friday August 14th as workers treat the area for fleas which may have led to a child contracting the plague.
The El Portal Road (continuation of Highway 140) into Yosemite National Park will is now open as of 6:00 p.m. this evening to all vehicular traffic. Intermittent traffic delays are possible due to on-going clean-up operations.
Highway 140 from Mariposa into Yosemite has closed due to a mudslide.
A massive sheet of rock has fallen from the vertical face of Half Dome, making one of the most popular routes attempted by climbers in North America even more challenging.
The National Park Service (NPS) has selected Yosemite Hospitality, LLC, a subsidiary of Aramark, to receive the new primary concession contract for providing visitor services in Yosemite National Park. The 15-year contract – the largest single concession contract in the NPS – is expected to begin on March 1, 2016, and will include overnight accommodations, […]
It's Memorial Day weekend and you're thinking to yourself, man, I sure want to get out of town. So, what's open in Yosemite? Here's a quick rundown of what's open and some hints that'll save you a headache.
If you're sitting over at Grandma's this Christmas and that awkward silence creeps in, grab your phone and take a virtual tour of Yosemite.
Talk about early Christmas presents, here's a wonderful one from mother nature. Rain and snow!
If you've never been to Tuolumne Meadows then you're missing out on one of the best parts of Yosemite, in my opinion. It's a broad, grassy valley surrounded by sharp, knife-edged peaks and domes that makes for some very beautiful scenery. But it's always been a bit of a mystery how the meadow and the unique mix of geological features surrounding it formed. Now researchers think they may have uncovered clues to how the meadow formed and likely it has to do with the way the Sierra Nevada itself formed.


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- Show games in:
Sort by:Newest | Alphabetical
Jingle Brawl
Use the code "WASTELAND" to unlock Aang's environment!
The Ultimate Enemy Face-Off
Pit ghastly gladiators against each other in a battle for boo-premacy!
Urban Jungle Rumble
Join the ultimate battle for supernatural supremacy!
- SpongeBob SquarePants: "What Happens Next?"
Are you a hardcore SpongeBob fan? Test your knowledge by guessing what happens next in these classic scenes!
- Game: Power Packed
You can battle cards with your favorite Nickelodeon characters, build a deck, try a daily quest, and more!
- Nicktoons: Dance Off, Clash On!
Baddies are crashing the Nicktoons par-tay. Dance them back out the door!


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UFC Hall of Famer Randy Couture talks about his fight with Lyoto Machida at UFC 129 and about fighting before 55,000 people at the Rogers Centre in Toronto. Get more MMA and UFC news at the World's t watch video >>
Download our iPhone app here http://www.mmafighting.com/iphone-download For more check out http://www.mmafighting.com watch video >>
Jake Shields talks about his debut with the UFC against Martin Kampmann, his upcoming UFC 129 fight against GSP, and Daniel Cormier is interviewed as well. watch video >>
Follow Mark Bocek on Twitter
http://twitter.com/markbocek watch video >>
http://TheMMAdigest.com watch video >>


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The house is very nicely set up and very welcoming to guests. It would be great for 2-3 couples or a family. We enjoyed the hot tub and the spacious kitchen. The house, is, however, closer to neighbors than we would like. The neighborhood is very quiet, but we prefer more distance. Great walking paths off the back of the... more
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I finally found out what I am having :) a boy. And now my family wants me to do a baby registry. The only thing is, I honestly do not know what to put in the registry. This is my first child.
Baby Registry Help!
Comments (7)
Babies r us has a new mommy checklist of common items to put on your registry. You probably won't need everything, but it gives you a place to start.
Best part is actually going to the store and scanning everything you see! Have fun with it.
My mom always says... it's your first baby, put whatever you want on there! Make a list of stuff that you know you need like a crib and a bath tub and stuff like that. Once you get to the store, you'll look around and see other stuff you find useful as well. Or you could always ask your mom for advice :)
That's what I came up with off the top of my head. Definitely check out a checklist. Many websites have one.
Emma Rose born 12/20/2009
Brianne Kaylee born 02/23/2013
Emma Rose born 12/20/2009
Brianne Kaylee born 02/23/2013
Don't forget a diaper hamper,teething rings, sippy cups (not everyone puts these on a registry but we did) bibs, binkies, mittens so baby doesn't scratch his face, a crib set(blankets and stuff) a mobile, a bouncer and/or a swing, maybe a boppy pillow for feeding or rocking, maybe a glider if you want one or a rocker, and maybe a baby book if you don't plan on getting one yourself. but like the other ladies said, you can find checklists!
There's actually a checklist on this site as well... www.babycenter.com/0_checklist-baby...
I've been using that as a guideline myself, but there's definitely some stuff on there I won't be getting. Make sure you tailor to your needs. :)


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England Lions v Bangladesh A - third ODI highlights - Taunton
Century from Naeem Islam helps tourists to a consolation victory over in the final game of their 50-over tour
6:06 mins |
You are :
Hugo leads the way Hugo Blogg is the youngest umpire in the country, having passed his Level One Umpires course aged only 12
1st NatWest Int T20 - Pakistan Innings England did not have it all their own way in the 1st NatWest Int T20, as they were set a score of 127 to win.
1st NatWest Int T20 - England Innings England were set 127 to win the 1st NatWest T20 and the World Champions would wobble on their way to victory.
Sept 3 - Durham v Notts - Day 4: Notts still in charge despite slip LV= County Championship highlights from Emirates Durham ICG
3 Sept - Lancs v Hants - Day 4: Lancs overcome Adams resistance LV= County Championship highlights from Liverpool
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Vallarta Shores International Hotel
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It's all fun and games until...
... attacked it with hairspray. After all, it WAS the early 90's and I was still reeling from the fact that the amount of hairspray I used in the eighties was classified as a weapon of mass destruction to the environment. So clearly, when faced with a possible lizard attack I automatically grabbed my giant can of Rave. I'm pretty sure that lizard was from the future and a Terminator 2 lizard because all the hairspray did was anger it. We finally rid ourselves of ...
More PV & a taste of Sayulita
... week or so. It's kind of a chilled out, hippyish town and a good place to learn how to surf which I was thinking about trying...again. My first attempt in California about 20 years ago didn't go so well. Anyway, not so sure about Sayulita now after getting stung. In the meantime, I have to get a tube for my front tire since the rim is leaking air. Couple more days in PV and them....where? ...
Hola Mexico
... to Mexico (not with Royal Mail because apparently they're ridiculously slow here), then gave me advice on other places to go in the country, and lastly told me to stick around until the weekend was over. And I'm definitely glad I stayed for ...
Successfully navigated my way to PV
After working on a project at home since June I seriously needed a vacation. Some rest and relaxation were in order and my dear sweet sister felt the same, so we made a date to meet in Mexico. I found an Ayurvedic Spa and retreat center in Punta Mita called Villa Ananda. We arrange to meet in Phoenix and fly down to Puerto Vallarta. It was an all inclusive, not like the drink as much tequila as possible and eat ...
Home... For Now
... called Mario, a charismatic and chatty American-Mexican. At first I thought that "duende" meant "ocean" given that's what we have views of. That made perfect sense at the time! Weeks later we discovered that it's Mario's nickname. It's the Mexican equivalent of a leprechaun. What other Spanish words have been erroneously translated???
Here we have an array of surrogate pets, most in your face are the 4 chihuahuas. Did I hear ...


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Integrys Energy Group Inc.
Watch breaking news videos and read news updates about Integrys Energy Group Inc. on Crain's Chicago Business
ICC gets an earful on pending deal for troubled Peoples
Despite objections from consumer advocates and the city of Chicago, state utility regulators appear poised to bless Wisconsin Energy's deal to acquire the parent of Peoples Gas.
AG Madigan moves for emergency ICC hearings on Peoples Gas deal
Lisa Madigan is trying to force answers out of Peoples Gas acquirer Wisconsin Energy, which so far has said it has no plan to fix the Chicago utility's floundering gas-main replacement program.
Peoples Gas gas-main program a mess, auditor finds
A new report on the multibillion-dollar pipe-replacement plan paints a picture of mismanagement: no accurate cost projections and rising leaks.
Madigan hits Peoples Gas parent with subpoena
Illinois' attorney general has opened a probe into Peoples Gas' troubled gas-main replacement program, issuing subpoenas to Peoples' parent and contractors.
Wisconsin Energy deal for Peoples Gas parent takes big step forward
The pending $5.7 billion deal got a favorable recommendation today by a judge for the Illinois Commerce Commission.
Chicago sending city households back to ComEd
Unable to find cheaper electricity rates, Mayor Rahm Emanuel will send city residents and small businesses back to ComEd, ending the nation's largest such municipal power contract.
Feds OK Wisconsin Energy acquisition of Peoples Gas parent
Federal regulators have approved Wisconsin Energy Corp.'s proposed $9.1 billion takeover of Chicago-based Integrys Energy Group Inc. The Milwaukee Journal Sentinel reports the Federal Energy Regulatory Commission gave its approval Tuesday
AG Madigan: Put brakes on Peoples Gas' pipe program
Warning that Chicagoans are at risk of unaffordable heating bills, Illinois Attorney General Lisa Madigan wants Peoples Gas to back down from a pledge to replace all of the city's aging underground gas mains within 15 years.
Wisconsin Energy pledges to clean house at Peoples Gas
Wisconsin Energy promises to clean house at troubled Peoples Gas if state utility regulators endorse its $5.7 billion acquisition of Peoples' Chicago-based parent.
Here's how to clear the air on Peoples Gas deal
Peoples Gas' plan to replace the city's underground gas mains is vital—and very, very expensive. Here's how the Illinois Commerce Commission can change that.
The link between Peoples Gas' current troubles and its dalliance with Enron
The exec at the center of the Chicago utility's gas-main replacement controversy has seen trouble before. He's the one who crafted Peoples' ill-fated shell game with Enron.
ICC launches probe of Peoples Gas
State utility regulators moved today to open a new investigation into Peoples Gas' massive and troubled gas-main replacement program in Chicago.
Whistleblower alleges conspiracy at Peoples; ICC to vote on probe
State regulators will vote next week on whether to investigate an anonymous whistleblower's claim that Peoples Gas impeded an audit of its massive pipe-replacement program.
AG Madigan escalates fight over Peoples' soaring costs
Illinois Attorney General Lisa Madigan and the city of Chicago are turning up the heat in their effort to force the buyer of Peoples Gas to reform a massive, expensive gas-main replacement program.
Nicor starts $2 billion pipe replacement program
Nicor Gas is launching a $2 billion, nine-year program to replace about 1,000 miles of aging gas mains in its vast suburban service territory.


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Moose Hillock Campground
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Maine Back to New Hampshire
... a lift in one of the support towers for a great view. The fort was fantastic as you could just wander around and get totally lost in all ...
Calm Before the Storm
... not merit a photograph. The restaurant is known for their guacamole made table side with fresh ingredients. The sangria was sweet, but a nice end to a hot day!
But as good as it was, it did not compare to the tasty dinner Nancie Severs prepared, a very savory blackened mahi mahi, accompanied by a wonderful salad of mixed field greens, orange ...
Dancing on Thin Ice
This has been the winter that won't quit. And, it has been the year that I haven't been able to take my usual "sunny break trips." When we had another few inches of snow on April 8. I looked at the tracks left by early spring birds and comforted myself saying, it looks and feels like January but the "sunny break" is bound to be just days away.
While I wait I've been reading Rachel Naomi Remen's book "Kitchen Table Wisdom." I restarted my ...
Vermont - During Fall (Sep-Nov)
That time of the season when everything falls to rise again......nature at its best!!!
Vermont is a state in the northeastern U.S. known for its natural landscape, which is 75% forest. It's also known for a major producer of maple syrup. Thousands of acres of alpine terrain make it a popular New England winter destination for skiers and ...
... 10 90;очно, в общем- 090;о. И внутр 77;нняя часть штата явно таит в себе множе 89;тво сюрпр 80;зов, ...


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For the first time in network history, Comcast SportsNet will air commercial-free telecasts of the White Sox vs. Los Angeles Dodgers spring training game on Saturday, March 15 at 9:00 p.m. and the Cubs vs. Cleveland Indians spring training game on Sunday, March 16 at 3:00 p.m.
The spring training telecasts on CSN will be presented by Xfinity (White Sox) and Chicagoland and Northwest Indiana Toyota Dealers (Cubs). The network will showcase one-on-one player interviews, player profiles, plus entertaining feature stories that fans will not want to miss.
[MORE: Complete White Sox news]
"We wanted to start off our coverage of the 2014 Chicago baseball season in a big way by taking the time we would normally air commercials and provide some very unique content for our viewers," Comcast SportsNet Chicago VP/GM Phil Bedella said. "These special features and player profiles we have created will continue throughout all 15 of our spring training telecasts and will help viewers get to know and appreciate the emerging new talent that will be building blocks on both sides of town for years to come."
[RELATED: Complete Cubs news]
Among the in-game features that viewers can look forward to this weekend include:
White Sox
- Center fielder Adam Eaton takes CSN Chicago on a fishing trip.
- First baseman Jose Abreu's strength and conditioning session with Allen Thomas.
- Third baseman Matt Davidson sits down with Chuck Garfien for an interview.
- Paul Konerko on what would define a successful final season.
- Pitching Cooper Don Cooper mic'd up.
- Catcher Josh Phegley straps on a Go-Pro camera while catching starter John Danks.
- Second baseman Darwin Barney one-on-one interview
- Pitcher Travis Wood on why he's had success at the plate.
- A game of H.O.R.S.E. between Cubs first baseman Anthony Rizzo, top prospect Javier Baez and outfielder Ryan Sweeney.


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Sports Talk Shows
Sponsored By
2015 Pittsburgh Penguins Season PreviewWith the Penguins season ready to get under way Thursday night with a road game against the Dallas Stars, lets take a look at a season preview for the team.
Bob Walk To Throw Out First Pitch At Wild Card GamePirates broadcaster Bob Walk will have the honor of throwing out the first pitch at Wednesday night's NL Wild Card Game between the Cubs and the Pirates at PNC Park.
Ben Roethlisberger Denies Reports He Could Return By Week 7Pittsburgh Steelers quarterback Ben Roethlisberger joined "The Cook and Poni Show" on Tuesday for the "#1 Cochran Ben Roethlisberger Show."
Ron Darling: Pirates Fans Have A Unique Ability To Take Over A Big GameMLB on TBS analyst Ron Darling joins The Fan Morning Show to talk about the NL Wild Card Game.
Ramon Foster Voices Feelings About Josh Scobee's StrugglesSteelers OL Ramon Foster discusses Josh Scobee's failure to get the job done against Baltimore.
Pat Narduzzi: Our Defense Wants To Be Even BetterPat Narduzzi was very pleased with Pitt's effort - especially when it came to the players on the defensive side of the ball.
Jeff Reed: Give Me A Tryout & If I Suck, Don't Sign MeFormer Steelers kicker Jeff Reed weighs in on fans wanting the team to bring him back to replace Josh Scobee.
NFL Analyst Steve Mariucci: Haley Going To Have Work Cut Out For Him With VickSteve Mariucci tells Cook and Poni that Haley will have his hands full trying to find the right mix for Vick on a short week.
Brett Keisel: Steelers Vs. Ravens Is Always A Bloodbath Former Steelers DE Brett Keisel joined "The Fan Morning Show" to preview tonight's Thursday Night Football matchup against the Ravens.
Ben Roethlisberger On Timetable For Return From Injury: 'I Don't Know'Speaking for the first time since suffering a sprained MCL and bone bruise against the St. Louis Rams, Steelers Quarterback Ben Roethlisberger portrayed a bit of optimism despite what originally looked like a season ending injury.
Ramon Foster: Vick Can Get The Job DoneSteelers OL Ramon Foster joins The Fan Morning Show
Former Pirates Skipper Jim Leyland Thinks Pedro Should Play And Forget About Getting Revenge On The CubsFormer Pittsburgh Pirates Manager Jim Leyland joined The Cook and Poni Show on Thursday to discuss the Pirates clinching a third straight postseason berth.


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updated 11/24/2010 AT 2:00 PM ET
•originally published 11/30/2010 AT 7:50 AM ET
Don't expect Mandy Moore to be counting calories over the holidays.
"I'm not obsessive about [dieting]," Moore, 27, told PEOPLE at the Tangled press event held at Disneyland recently.
"If I want to have a burger and fries like I did [the other] night in the park, then I'm going to do that because that's okay," she says.
But Moore, who wed musician Ryan Adams last year, hasn't always been so easy-going. She admits in the past she has sometimes placed too much emphasis on her weight.


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Latest Headlines
Latest Headlines
Merck-partnered Euroscreen raises €16M to support IND filing
Euroscreen has topped up its bank balance to support the globalization of its clinical trial program. The €16 million ($18 million) round will allow the g-protein coupled receptor (GPCR) specialist to file an IND and advance ongoing Phase II trials of its lead candidate in women's health diseases.
Pfizer adding jobs to Ireland plant that had been slated to close
Pfizer announced plans to sell a plant in India that was slated to be shuttered. But another Pfizer facility in Ireland that was once on the chopping block has not only been taken off the list of facilities no longer needed but is adding several dozen jobs.
Galapagos targets RA deal by year end; French dwarfism firm bags $35M; Verona eyes PhIIb
In this week's EuroBiotech Report, having been rejected by AbbVie, Galapagos hit the gas on its partnering strategy. Several potential partners are already giving the data the once-over, potentially putting Galapagos in a position to meet its goal of having a new deal in place by the end of the year. And more.
OrbiMed leads $35M round to push dwarfism startup to POC
OrbiMed has joined with New Enterprise Associates and Versant Ventures to funnel $35 million (€31 million) into a French startup that is developing a treatment for a common form of dwarfism. The sizable Series A round will support the advance of the program to clinical proof of concept.
Verona sets sights on PhIIb after COPD drug comes through early trial
Verona Pharma has come through one of the last major barriers between it and the start of a Phase IIb trial of its chronic obstructive pulmonary disease (COPD) drug. The news means that, after years of largely unsuccessful R&D into phosphodiesterase inhibitors, another company is nearly ready to test a product from the class in a late-phase trial.
Oasmia adds warrants to sweeten Nasdaq IPO deal as closing date nears
Oasmia Pharmaceutical (STO:OASM) has made another change to its upcoming NASDAQ IPO. The nanotechnology specialist is now planning to hand out one warrant for every two shares it sells in the IPO, positioning it to boost its fundraising haul by more than 60% if investors take up the option to buy stock at the predefined price.
Galapagos pushing to find partner to replace AbbVie by year end
Galapagos is looking to bounce back quickly from AbbVie's decision to walk away from their rheumatoid arthritis alliance. The aim is to have a new partnership deal in place by the end of the year, giving Galapagos the support it needs to go head-to-head with ally-turned-rival AbbVie in the scrap for the rheumatoid arthritis market.
Apitope raises €12M for autoimmune pipeline, commits to HQ relocation
Apitope has raised €12 million ($13 million) to advance its lead candidates into the clinic. The Merck Serono-partnered autoimmune specialist will funnel the cash into the advance of in-house peptides for the treatment of Factor VIII intolerance in hemophilia A patients and Graves' disease.
Roche, Boehringer and Gilead line up for EU drug approvals
The European Medicines Agency is moving toward approving a trio of novel medicines from Roche, Boehringer Ingelheim and Gilead Sciences, handing down positive recommendations for each.
Sientra off by more than 50% after it discloses CE mark suspension for its contract manufacturer
Breast implant company Sientra saw its valuation cut in half on news that its contract manufacturer Silimed has had its CE mark suspended by the U.K. Department of Health. The move came after German regulators conducted an inspection of a Brazilian manufacturing plant--and regulators found that "the surfaces of some implants were contaminated with particles."


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Stock Market & Financial Investment News
News Breaks
March 5, 2014
EPIX to launch on Time Warner Cable on March 18
Time Warner Cable (TWC) yesterday announced it will be launching entertainment network, EPIX, nationally on March 18, 2014. The launch will deliver thousands of movies and original programs including documentaries, concerts and comedy specials to Time Warner Cable customers across four new channels: EPIX, EPIX 2 and EPIX 3 plus EPIX Drive-in. EPIX is a joint venture between Viacom (VIA, VIA.B), its Paramount Pictures unit, Metro-Goldwyn-Mayer Studios and Lionsgate (LGF).
News For B;LGF From The Last 14 Days
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October 8, 2015
Lionsgate expands outpout deal with France's Metropolitan Film Export
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October 6, 2015
Lionsgate, Starz merger would benefit both companies, says B. Riley
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October 5, 2015
Lionsgate, Starz in advanced merger discussions, LA Times says
Mini-major studio Lionsgate (LGF) is in advanced talks to merge with movie channel Starz (STRZA), according to the Los Angeles Times, citing four people with knowledge of the matter.
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Lionsgate and Skydance Media form global television distribution agreement
Lionsgate announced that the two companies have formed a global television distribution pact. The launch of newly-created label Skydance International, which will feature Skydance Media's current and emerging premium television properties around the world following their initial U.S. broadcast, augments Lionsgate's worldwide distribution pipeline and permits the two companies to tap opportunities across the global television marketplace.
October 4, 2015
'The Martian' soars in box office debut
Science fiction film "The Martian" rocketed to the top of the box office amid widespread critical acclaim. WEEKEND LEADER: Fox's (FOX, FOXA) "The Martian" grossed $55M in its domestic open for the weekend of October 4, beating expectations for $40M-$50M and nearly setting a record for October debuts. Director Ridley Scott's return to science fiction after 1979's "Alien" and the more recent "Prometheus" was applauded by critics and audiences alike, with "Martian" garnering a 94% approval rating on review aggregator Rotten Tomatoes. BOX OFFICE RUNNERS-UP: Sony's (SNE) "Hotel Transylvania 2" stepped down to second place with $33M after last weekend's strong open, while Lionsgate's (LGF) drug cartel thriller "Sicario" earned $12.1M after expanding nationwide, outpacing expectations for $8M-$10M. Rounding out this weekend's Top 5, Time Warner (TWX) subsidiary Warner Bros.' "The Intern" and Fox's "Maze Runner: The Scorch Trials" took in a respective $11.6M and $7.7M.
October 2, 2015
Fly Watch: 'The Martian' expected to win weekend box office
Fox's (FOX, FOXA) "The Martian," based on the best selling science fiction novel by Andy Weir and starring Matt Damon, is expected to win this weekend's box office with an opening of between $40M-$50M. Sony's (SNE) animated sequel "'Hotel Transylvania 2," which set a record last weekend for a September opening with a $48.5M debut, is estimated to gross in the range of $29M-$31.5M in its second week. Lions Gate's (LGF) drug cartel drama "Sicario," which opened two weeks ago in six theaters and expanded to 59 theaters last week, is expected to take in $8M-$10M in its first weekend expanding nationwide, now playing in about 2,500 theaters. Time Warner (TWX) subsidiary Warner Bros.' comedy "The Intern," starring Robert DeNiro and Anne Hathaway, is estimated to bring in $8.5M-$8.9M in its second weekend. Fox's "Maze Runner: The Scorch Trials" is expected to earn an estimated $7.8M in its third weekend of release. Also new in theaters is Sony subsidiary TriStar's "The Walk," starring Joseph Gordon-Levitt, which opened Wednesday exclusively on 448 IMAX (IMAX) and large-format screens, and is expected to earn $3M through the weekend.
October 1, 2015
Lionsgate wins rights to 'The Kingkiller Chronicle', Hollywood Reporter says
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Barnes Group acquires Priamus System Technologies, terms not disclosed
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September 30, 2015
Lionsgate signs deal with Buena Vista International for distribution in Russia
Lionsgate has forged an output deal with international theatrical distributors Buena Vista International for distribution of Lionsgate titles in Russia and the rest of the Commonwealth of Independent States. The agreement will kick off with Lionsgate's revenge thriller Sicario this fall.
September 25, 2015
Fly Watch: 'Hotel Transylvania 2' expected to top weekend box office
Sony's (SNE) animated sequel "'Hotel Transylvania 2," which is opening in 3,600 theaters, is expected to win this weekend's box office with a domestic gross of $35M-$40M. The next bunch of films are all expecting similar grosses in the mid-to-high teens. Time Warner (TWX) subsidiary Warner Bros.' comedy "The Intern," starring Robert DeNiro and Anne Hathaway, is estimated to open in the $15M-$20M range in 3,305 theaters. Comcast (CMCSA, CMCSK) subsidiary Universal's "Everest," which opened last weekend on IMAX (IMAX), is expanding to over 3,000 theaters this weekend and is estimated to gross in the range of $15M-$17M. Fox's (FOX, FOXA) "Maze Runner: The Scorch Trials," which grossed $30.3M domestically for the weekend of September 20, is expected to earn an estimated $16M in its second weekend of release. Warner Bros.' Whitey Bulger biopic "Black Mass," which took in $23.4M in its domestic opening last weekend, is expected to gross $12.5M-$13M this weekend. Additionally, Lions Gate's (LGF) drug cartel drama "Sicario" is playing in about 50 theaters ahead of the film's wide release on October 2.
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