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SOURCE: The Island Packet (SC)
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Centuries-old canoe unearthed in sand near Daufuskie IslandBreaking News
A bit of centuries-old history has been freed from the muck off Daufuskie Island.
The dugout canoe, probably hand-hewn in the 18th century, was first found on Turtle Island in May. Daufuskie Island residents and University of South Carolina archaeologists, aided by natural erosion around the craft, were able to break the mud's grip Oct. 4.
James Spirek, a USC underwater archaeologist, oversaw the dig and says the boat probably was hand-carved from a single log.
By whom remains a mystery....
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- Norma Basch, pioneer in legal history, has died
- National History Day Helps 600,000 Kids Bring the Past to Life
- Finally some good news for history grads
- Historians issue statement in support of European migrants
- Conservative historian Arthur Herman slammed for saying Obama is highly submissive to Putin and other strong leaders

subset: commoncrawl


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realmagick.com The shrine of knowledge.
Bodhi Quotes
A selection of articles related to bodhi quotes.
Original articles from our library related to the Bodhi Quotes. See Table of Contents for further available material (downloadable resources) on Bodhi Quotes.
- Bodhi: Correspondences
- Ficus religiosa Folk Names: Bo-Tree, Peepul Tree, Pipul, Sacred Tree Gender: Masculine Planet: Jupiter Element: Air Deity: Bhudda, Vishnu Power: Fertility, Protection, Wisdom, Meditation...
Herbalism >> Herbs dictionary B
- The Necronomicon
- There are those who believe in this grimoire, in its existence and in its potency, and there are those who do not. Those who believe say that this grimoire, originally named Al Azif, and written by Abdul Alhazred around 700 AD, contains the rituals that, if...
Deities & Heros >> Chthulu
- Starting with Jesus and the Christian Path...
- During the years of the historical Jesus' life, there are eight or nine years that his whereabouts are not accounted for. Meaning these are the 'lost' years. It was after returning that he truly began to teach his wisdom. Many scholars believe he was in India...
Religion & Philosophy >> Religions
- Religious Tolerance In Springfield and the Greenleaf Coven
- Religious intolerance is alive and well in Springfield Missouri. The question is, to what degree, and in the terminology of "The Burning Times", how high are the flames? In 1999, the court case of Jean Webb vs. The City of Republic was a headliner...
Paganism & Wicca >> True Stories
- The Twilight of the Celtic Gods
- The Milesians, according to myth, were the first Celts to settle in Ireland. This group was named after the eight sons of Mil (some texts say King Milesius); these Gaelic peoples, the myths report, came to Ireland from Spain. Ironically, the first phase of...
Saga of Times Past >> Legend and Prehistory
- Building Shadows: A Witch
- A witch's Book of Shadows. That mysterious Grimoire that holds all the information a witch will ever need, a volume of all the spells ever written, the magic of the ages bound together with paper and ink…. Poppycock. It is not some ancient arcane book that...
Religions >> Paganism & Wicca
Bodhi Quotes is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Bodhi Quotes books and related discussion.
Suggested Pdf Resources
- Truthfulness quotes
- Essay on Truthfulness by Bhikkhu Bodhi. What is verbal conduct in accordance with the Dhamma?
- media.audiodharma.org
- Marsha Craig April 2011 Bodhi's Buzz New Home Updates Editor's
- Jun 21, 2011 June Bodhi Buzz. Having trouble One of my favorite prosperity quotes by .
- www.bodhispiritualcenter.org
- Understanding fstab
- Quote: I don't mount any vfat shares but uid and gid work with smbfs shares. .. Note: Ownership has changed !
- blog.bodhizazen.net
- Jain Fundamentals Jain Rituals Jain Scriptures Jain Compassion
- Compassionate Quotes. Compiled by: Pravin K. Shah.
- www.fas.harvard.edu
- Daniel Miracapillo
- www.fudenji.it
Suggested Web Resources
- Point Break (1991) - Memorable quotes
- Point Break Quotes on IMDb: Movies, TV, Celebs, and more...
- www.imdb.com
- Bodhi (Character) - Quotes
- Bodhi (Character) on IMDb: Movies, TV, Celebs, and more...
- www.imdb.com
- Point Break (1991) - IMDb
- www.imdb.com
- Bhikkhu Bodhi Quotes
- 1 quote from Bhikkhu Bodhi: 'In this world everything changes except good deeds and bad deeds; these follow you as the shadow follows the body.
- www.goodreads.com
- Point Break - Wikiquote
- Jun 14, 2011 Bodhi: Did you know that we've hit thirty banks in three years and they weren't Grommet: [nervously shouting] Fuck the stakes Bodhi! .
- en.wikiquote.org
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Was Bill Walton Drunk Or On Drugs During This Basketball Game? [Video]
Check out the short Vine video and then determine for yourself if NBA great Bill Walton was drunk while calling this basketball game.
Check out the short Vine video and then determine for yourself if NBA great Bill Walton was drunk while calling this basketball game.
Someone sent Eric Zane some mail to the radio station.
They obviously know how much of a pizza aficionado Zane is. So, they figured he'd enjoy some nice, light reading.
In case you missed it, a woman on "Wheel of Fortune" almost solved a puzzle on Tuesday night's show.
However, she didn't know that Sneezy was one of the Seven Dwarfs.
Move over ice cream in a little batting helmet.
There's a new greatest ballpark dessert ever in town!
There's no way you've seen anyone this excited about pizza before.
Ever heard of strawpedoing a drink?
William Long has had a pretty rough go at it.
All in all, he's spent 39 of his 53 years in prison.
This just goes to show you how stupid some people can be when it comes to meeting someone they think is famous.
As if skydiving wasn't scary enough, being in the situation this guy was in is worse than any of us might imagine.
Nelson Shanks is an artist who got the incredible opportunity to paint former President Bill Clinton's official presidential portrait for the National Gallery of Art.
That's quite an honor. So, naturally he decided to stick it to Clinton.


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1983 Ford Fairmont • 194,000 miles
I have a 83 ford fairmont futura and with key off and out I still have votalge to the starter from starter soldinod and drains my battery
January 3, 2013.
January 3, 2013.
Check out the related content below while we wait for the question to be answered by a professional mechanic.
1994 Toyota 4 runner in great shape with a dealer rebuilt v6 about 25k on new motor. I turn the key it clicks at the starter. After finding the starter most well hidden ive ever found ...
2 answers • 1994 Toyota 4Runner • 200 miles


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updated 06/21/2012 AT 11:00 AM ET
•originally published 06/21/2012 AT 11:35 AM ET
Halle Berry, mother to 4-year-old daughter Nahla with Gabriel Aubry, reportedly has some stiff child-support payments ahead of her.
After a court appearance earlier this week, Berry, 45, has been ordered to pay Aubry $20,000 a month, which adds up to nearly a quarter of a million dollars a year, reports TMZ.com.
Berry and Aubry, a French-Canadian model, split in April 2010 and have been locked in a custody battle over Nahla.


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Athar M, Back JH, Tang X et al.Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224:274-283
ABSTRACT The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds one of which is resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin derived from the skin of grapes and other fruits. Resveratrol is known to have potent anti-inflammatory and antioxidant effects and to inhibit platelet aggregation and the growth of a variety of cancer cells. Its potential chemopreventive and chemotherapeutic activities have been demonstrated in all three stages of carcinogenesis (initiation, promotion, and progression), in both chemically and UVB-induced skin carcinogenesis in mice, as well as in various murine models of human cancers. Evidence from numerous in vitro and in vivo studies has confirmed its ability to modulate various targets and signaling pathways. This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations.
Full-textDOI: · Available from: Mohammad Athar, Feb 11, 2015
- SourceAvailable from: Manish Kumar Jeengar
- "Interestingly some natural products have shown synergistic effects with chemotherapeutic drugs and are also effective against multi drug resistance cancers (Athar et al., 2007; Gu et al., 2013; Liu and Chen, 2013). Boswellia ovalifoliolata (BO), an indigenous plant is mainly found in the areas of nilgiri hills of southern India. "
Article: Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells[Show abstract] [Hide abstract]
ABSTRACT: The present study was aimed at evaluation the apoptogenic potential of ethanolic extract of leaves from Boswellia ovalifoliolata (BL EthOH) and to explore the mechanism responsible for those activities implicated in Triple Negative Breast Cancer (TNBC) cells. BL EthOH was cytotoxic against TNBC cells like MDA-MB-231 and MDA-MB-453 with IC50 concentrations 67.48 ± 5.45 and 70.03 ± 4.76 μg/ml respectively. Apoptotic studies showed that BL EthOH was able to induce apoptosis and western blot studies demonstrated that BL EthOH significantly decreased the Phospho-NF-κB (ser536), PCNA, anti-apoptotic protein Bcl-2 expression and increased the expression of pro-apoptotic protein Bax, in MDA-MB-231 and MDA-MB-453 cell lines when compared with untreated cells. Besides, BL EthOH has synergistic chemosensitizing effects on TNBC cells and increased the cytotoxicity of doxorubicin and cisplatin.Environmental Toxicology and Pharmacology 07/2014; 38(1). DOI:10.1016/j.etap.2014.05.002 · 2.08 Impact Factor
- "Therefore, it will be also interesting to examine whether REV and its oligomers have the potential to be useful as therapeutic agents for the treatment of other types of IR-induced tissue damage. Interestingly, it has been reported that a variety of cancer cells, including gastric, colorectal, lung, breast, prostate, esophageal, and thyroid carcinomas, can be inhibited by REV and its oligomers [25, 26]. Therefore, REV and its oligomers have the potential to increase the therapeutic efficacy of radiotherapy, not only by reducing tissue injury but also by inhibiting tumor growth. "
Article: Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries[Show abstract] [Hide abstract]
ABSTRACT: Ionizing radiation (IR) is known not only to cause acute bone marrow (BM) suppression but also to lead to long-term residual hematopoietic injury. These effects have been attributed to IR inducing the generation of reactive oxygen species (ROS) in hematopoietic cells. In this study, we examined if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression. The results of cell viability assays, clonogenic assays, and competitive repopulation assays revealed that treatment with these compounds could protect mice BM mononuclear cells (BMMNC), hematopoietic progenitor cells, and hematopoietic stem cells from IR-induced BM suppression. Moreover, the expression of genes related to the endogenous cellular antioxidant system in hematopoietic cells was analyzed. The expression and activity of SOD2 and GPX1 were found to be decreased in irradiated BMMNC, and the application of the resveratrol analogues could ameliorate this damage. Our results suggest that in comparison with resveratrol and isorhapontigenin, treatment with heyneanol-A can protect hematopoietic cells from IR-induced damage to a greater degree; the protective effects of these compounds are probably the result of their antioxidant properties.BioMed Research International 06/2014; 2014:282657. DOI:10.1155/2014/282657 · 3.17 Impact Factor
- "Animal studies reporting beneficial effects of resveratrol in cancer have recently been published (Athar et al., 2007). "
Article: Role of microRNAs in Resveratrol-Mediated Mitigation of Colitis-Associated Tumorigenesis in Apc(Min/+) Mice[Show abstract] [Hide abstract]
ABSTRACT: The pleiotropic effects of resveratrol include anti-inflammatory, antioxidant and anti-cancer activities, and thus unique possibilities exist to explore mechanistic pathways of chemoprevention. The aim of this study was to investigate the role of miRNA alterations induced by resveratrol in the context of chemopreventive mechanisms against dextran sodium sulphate (DSS) induced colitis-associated tumorigenesis in the ApcMin/+ mouse. To that end, ApcMin/+ mice were exposed to 2% DSS to enhance intestinal inflammation and polyp development. Concurrently, mice received either vehicle or resveratrol treatment via oral gavage for five weeks. Interestingly, treatment of DSS-exposed mice with resveratrol resulted in decreased number and size of polyps, fewer histological signs of cell damage and decreased proliferating epithelial cells in intestinal mucosa compared to vehicle. Resveratrol treatment dramatically reversed the effects of DSS on the numbers of specific inflammatory CD4+ T cells, CD8+ T cells, B cells, natural killer T (NKT) cells and myeloid derived suppressor cells (MDSCs) in mesenteric lymph nodes. Resveratrol treatment also decreased IL-6 and TNF-α protein levels and reduced IL-6 and COX-2 mRNA expression. Microarray analysis revealed 104 microRNAs exhibiting greater than 1.5-fold differences in expression in the intestinal tissue of resveratrol treated mice. Among them, two microRNAs with anti-inflammatory properties, miRNA-101b and miRNA-455, were validated to be upregulated with resveratrol treatment by RT-PCR. Pathway analysis revealed that numerous differentially regulated miRNAs targeted mRNAs associated with inflammatory processes with known roles in intestinal tumorigenesis. These results suggest that resveratrol mediates anti-inflammatory properties and suppresses intestinal tumorigenesis through miRNA modulation.Journal of Pharmacology and Experimental Therapeutics 05/2014; 350(1). DOI:10.1124/jpet.114.213306 · 3.97 Impact Factor


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With a built-in heating element, the Soup3rb Heat + Blend from 3 Squares promises to whip up dinner in no time.
If you want an arcade racing game that's less like a simulator and more about speeding down the track while grabbing bonus items, Asphalt 7 is one of the best in the App Store.
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I watch Button Poetry on Youtube. It's a Youtube channel for slam poetry performances. Also gameplays from Vanossgaming, Pewdiepie, H2ODelirious, DaithideNogla, IAMWILDCAT, Mini Ladd, Lui Calibri, BasicallyDoWork, Moo Snuckel and more.
I like people with a good way of expressing themselves through writing because I love diving into people's point of views and it amuses me how they deliver their thoughts. I like people who appreciates me. Especially my literary pieces.


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text: andrew cuomo Medical Marijuana Becomes Legal In New York By Karen Dewitt • Jul 7, 2014 Governor Cuomo's Office Listen Listening... / 3:17 New York is now the 23 state to allow medical marijuana, now that Governor Cuomo has signed a bill into law. But, as Karen DeWitt reports, it will be some time before patients will have access to the drug. Tentative Deal On Common Core Test Moratorium For Teachers By Karen DeWitt • Jun 19, 2014 Listen Listening... / 0:49 A tentative agreement has been reached by New York Governor Cuomo and the legislature to put off the effects of the controversial Common Core tests on teachers for another two years. New York Legislative Session Could End With A Whimper By Karen Dewitt • Jun 16, 2014 Office of Governor Andrew Cuomo Listen Listening... / 3:15 The legislative session is scheduled to end on Thursday, and many issues remain unresolved. But a low key end of session might not matter much to New York's top political figures. Greenberg On Latest Siena Poll Results By Brian Shields • Jun 16, 2014 Steve Greenberg discusses Siena College's poll results for the New York State gubernatorial race. Results show Governor Cuomo with a lead over Westchester County Executive Rob Astorino. Cuomo To Up Fight Against Heroin By Hank Gross • Jun 11, 2014 Lucas Willard / WAMC Listen Listening... / 0:53 Acknowledging that heroin use is at epidemic proportions, New York Governor Andrew Cuomo came to Rockland Community College in Suffern Wednesday to announce a multi-pronged approach to fight the scourge. Cuomo Says He's Proud Of Lack Of Partisanship In Albany By Karen Dewitt • Jun 5, 2014 Office of Gov. Andrew Cuomo Listen Listening... / 3:13 Governor Cuomo tried to change the subject with two economic development appearances, in the aftermath of a political endorsement that has shaken up the Capitol. Upstate NY Questions Cuomo's Alliance With WFP By Karen DeWitt • Jun 4, 2014 Pat Arnow Listen Listening... / 3:17 The fallout from Governor Cuomo's new alliance with the progressive Working Families Party continues at the Capitol, with those who say they represent upstate interests dismayed at the development. Astorino Pressing For Term Limits, But Not Public Financing By Karen Dewitt • May 29, 2014 WAMC Photo by Dave Lucas Listen Listening... / 3:32 The Republican candidate for governor of New York, Rob Astorino, is pressing for term limits for state officials. He also spoke against another reform proposal percolating in the legislature, campaign finance reform, on Wednesday. Politics A Factor In Final Weeks Of Legislative Session By Karen DeWitt • May 23, 2014 Listen Listening... / 3:42 Now that the major party political conventions are over, New York officials are shifting their focus back to the remaining issues in the legislative session, which ends in four weeks. But politics will still be front and center in the waning days of the session. Govenor Cuomo Nominated For Second Term By Karen Dewitt • May 22, 2014 Matt Ryan Listen Listening... / 2:35 New York Governor Andrew Cuomo was nominated to run for a second term at the state Democratic convention Thursday in Long Island, along with his freshly chosen running mate, former Western New York Congresswoman Kathy Hochul. Pages« first ‹ previous … 2 3 4 5 6 7 8 9 10 … next › last »


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All Seasons Crepe Bootcut Pants: A bestselling pant fit now in our famous, all-season crepe fabric. Pair these flattering pants with our All Seasons Crepe Blazer for a classic suited look.
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Ordered these pants for work and even ordered up a size. I am 5'7" and 165. Sadly disappointed in the size/fit of these pants.
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The pants fit perfect. I get a lot of compliments. Great color.
A hands-down winner
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George Clooney admits talking to Amal makes him feel like an 'idiot'
George Clooney has admitted he often feels like an "idiot" when talking to his wife, the human rights lawyer Amal Clooney.
Welcome to the new Independent website. We hope you enjoy it and we value your feedback. Please contact us here.
George Clooney has admitted he often feels like an "idiot" when talking to his wife, the human rights lawyer Amal Clooney.
Chris Parks says Alfonso Cuaron used the technology properly
The biggest opening of George Clooney and Sandra Bullock's careers
Star claims spy satellite he funds helps to curb murderous tendencies of ruler
US crime writer Elmore Leonard is recovering from a stroke in a Detroit hospital.
Where to go and what to know
Travel takes on a new meaning when you follow in the footsteps of film stars. You could request Bungalows 1, 7 or 21 at the Beverly Hills Hotel in LA, where Marilyn Monroe liked to stay, from $1,500. Or you could check into the Harlequin Suite at London's Dorchester where Richard Burton proposed to Elizabeth Taylor in the pink marble bathroom, which costs from £7,455 per night.
'I want to cuddle Boris Johnson'
The wonks over at the Daily Beast have produced a fascinating quantified rundown of how much celebrity supporters are contributing to this Presidential race, which is close to neck-a-neck as polling day approaches.
With The Bourne Legacy set for release, the actor tells Emma Jones that he chooses diverse roles to satisfy his need to be challenged
Murky things are happening on the Edinburgh Fringe – and it's not even August yet. This year's fastest-emerging trend is for bribery with three acts offering cash in return for bums on seats. Nathan Cassidy is giving audiences £1 to see his show Free Pound on the Free Fringe (ticket cost: "minus £1". Donations welcome). Elsewhere, Mark MacNicol has gone for a money-back clause: if audiences don't like his "sexy, sensual, dark" theatrical take on Fatal Attraction, he will refund the £8 ticket price from his own pocket. And Irish comedian Caimh McDonnell has taken the most audacious route, promising to donate £100 to Macmillan Cancer Relief for every review published in a "recognised media source" before 20 August (only one review per outlet, sadly). Will any of these stunts work? Or will it emerge that these are, in fact, shows you couldn't pay a man, woman or Arts Diarist to see? And whatever happened to old-fashioned flyering on the Royal Mile in the rain?
If you haven't heard of Heather Cocks and Jessica Morgan then you're obviously missing out on one of the greatest joys of the internet.
It was the annual White House correspondents' dinner on Saturday, hosted by the late-night talk star Jimmy Kimmel, and the Comedian-in-Chief Barack Obama didn't waste the opportunity, poking fun at himself and his administration (a little) and at his foes in the overheated political chamber of an American election year (a lot).
Hollywood star George Clooney and his father were released tonight following their arrest at a demonstration in Washington.
Who really deserves to win and who was disgracefully left off the shortlist?
My parents were... fantastic. My father was a rabbi, my mother was a typical Jewish mother who fussed over her children and thought they could do no wrong.


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Home Group is looking into the implications for its customers however, at this time we are unable to provide you with any information regarding the qualifying criteria until the amendments to the legislation have been released.
The details on this page around eligibility pre-date the recent announcement. You may want to complete the quiz on the link below to see if you qualify for the Right to Buy:
The discount depends on how long you have been a tenant (including any time spent as a tenant with another housing association, local authority or armed forces etc). The discount can be no more than 70% of the open market value. The longer you have been a tenant, the more discount you get, but whatever percentage you are eligible for, the current maximum discount is £77,900 or £103,900 (London Borough).
You may exercise the RTA if:
Discounts - based on local authority area - are set between £9,000 and £16,000.
You will NOT have the RTA if:
We can provide free advice on buying your home. If you are approached by private companies or individuals with offers of help, check out what they will gain from it. They may help submit an application, but may make a charge for this service. Please note that you can apply directly to Home Group, at no cost to you if you qualify for the Right to Buy or Right to Acquire. Help will be given, if needed, to complete the form.
If you have any questions, need further explanation about anything, or would like to apply please contact Anne Douse, Statutory and Resale Manager, Home Group Sales on firstname.lastname@example.com or leave a message on (0191) 290 7729.


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The young man at counter was extra nice to us. We were tired from driving 11 hrs and didn't expect much for the price. He really surprised us. The bathroom was clean and the bed was too! WiFi and aTV. That's what the doctor ordered. :)
The young man at counter was extra nice to us. We were tired from driving 11 hrs and didn't expect much for the price. He really surprised us. The bathroom was clean and the bed was too! WiFi and aTV. That's what the doctor ordered. :)
I stayed in the lower portion of the place and there was no wifi there, but there was a comfortable bed, hot wet shower and a TV that worked. The price was just north of $35 including tax, for 6 bux more I coulda had internet in a different room. The location is a short distance from Knoxville and has... More
We stopped for the night on our way to Gatlinburg. It was 1 am and the clerk was nice and it was an easy check in. Room was clean, no outside noise, and comfortable. A little dated but worth the price. The heater definitely was hot! Easy in, easy out.
This was a very nice motel and the price was great. Friendly staff and the check in was speedy. would definitely stay here again! Not sure if they offered breakfast or not , if so just a light one which was fine.
When I rent a room for the night I expect hot running water and a clean comfortable bed for a reasonable price. This place was all that and more. The woman behind the counter was very nice and was accommodating in giving us a room on the bottom part (flat parking) of the hill for our motorcycles. The room was... More
My 3 year old saw a little bug on the bed. We moved the mattresses and were horrified to find bedbugs hiding in crevice of bottom mattress and dried blood marks on mattress. We put one bug in a cup and brought it to office to our surprise she accused me of placing them in bed and were just trying... More
Bed bugs are a very serious issue in our industry today. This is not a subject to be taken lightly and one that is acted on immediately. Although we have our motel inspected regularly for any evidence of bed bugs, we also follow up immediately on any guest concerns. In the case of this guest, our contracted pest control company... More
Yes, Budget. No frills. Don't expect a buffet breakfast. In fact, the honey bun was inedible. But, I was very pleased with immaculate, nearly new tile in bathroom. Good tv reception. Good bed. Good deal.
Me and my husband were traveling to Michigan to meet family and we decided to stop for the night. The hotel was up on the hill but the view next day was beautiful with the leaves changing. The room was clean and comfortable beds. We will definitely stay there again.
One night stay on a Friday evening in mid-September. Room was clean with basic furnishings. A/C, lights and plumbing all worked fine. For $40 I wasn't expecting the Ritz and I thought it was a good value. Property is up on a hill and access isn't the easiest due to the steep hill. The parking lot had a huge pothole... More
When you arrive, the check-in girl, who speaks very poor english, will inform you, if you ask, that their continental breakfast (which is coffee and a honeybun only) will be served between 7-9am. But when you return for breakfast, you will discover that even though it is 7:20am, the door to the office is locked and a sign tells you... More
Super 8 Caryville
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text:
MomsRising.org wants to
Make Sure All Kids Have Access to Healthy Food!
Help our kids eat well and stay healthy.
Pioneers of Progress Inc. is a 501c3 non-profit youth mentoring organization. We aim to mold youth into productive citizens through education and mentorship.
Help our kids eat well and stay healthy.
Racially-motivated police violence has no place in law enforcement.
Petition for ErinMy son;A preacherBelieverAfrican Hero.LeaderSucceederThe ultimateAchiever.A boy who


text:
John Moore is riding shotgun for your drive home each Afternoon! He helps you put a wrap on the workday, weekday afternoons from 2 to 7!
Then, he rocks the drive home with The 5 O'clock CARTUNES.......An hour of Classic Rock to crank up between work and home!
The 5 O'clock CARTUNES Weekdays at 5pm. Call in your requests at 1-800-467-KGMO, text 800-467-5466, or hit keyword "REQUEST" at kgmo.com!
ALSO, PLAY THE NUMBER ONE GAME ON THE RADIO "WHATS IN MY POCKET?" with your chance to win!


text:
Ski Packages - Skis With Bindings - Women'sProboardshop.com is the leading skiing company on the web for Women's Ski Packages - Skis With Bindings. All skiing brands in stock for next day shipment with up to 50% savings. 29 years of great prices, selection, and service.
Please refine here More in the Outlet Shop.
- Color: White
- Price: => 600.00
K2 Superstitious Skis w/ Marker ERS 11.0 TC Bindings - Women's
Size: 146cmReg: $1260.00 On Sale: $649.95
K2 SuperStitious Skis w/ Marker ERS 11.0 TC Demo Bindings - Women's
Size: 146cm, 153cm, 160cm, 167cmReg: $1260.00 On Sale: $649.95


text:
pftq is not a company. pftq is not a top-secret military project. pftq isn't a new language or code. pftq isn't a bunch of random letters (Well okay, maybe it is).
pftq is just a random guy with too much time on his hands!
"Delusions of grandeur? As in dreams and aspirations?" - July 29, 2010 »


text:
Low Cost Pet Vaccinations, Garland, TX
VCA Pet Doctor Animal Hospital
1421 E Spring Valley Rd, Richardson, TX 75081
VCA Animal Hospital
11680 Forest Central Drive, Dallas, TX 75243
VCA Lindley Animal Hospital
8518 Plano Rd, Dallas, TX 75238
- Casa Linda Animal Clinic
- Call today for an appointment
- 11434 Garland Road,, Dallas, TX 75218
- Summertree Animal & Bird Clinic
- Call today for an appointment
- 12300 Inwood Road Suite 102,, Dallas, TX 75244
- Arbor Hills Veterinary Centre
- Call today for an appointment
- 3501 Midway Rd Ste 290,, Plano, TX 75093
Dallas Dog Services
Serving Garland, TX
4.2 Miles
"Lisa at Dallas Dog Services help me out of a bind, I had a last min. trip and no one to care...">
LOW Water-Pressure Problems
2083 Summer Lee Dr, Rockwall, TX 75032
9.4 Miles
"Good Value and Honest People***** they arrived on time, were very friendly and professional ...">
Hot Diggity Dog
3820 Main St, Rowlett, TX 75088
4.4 Miles
"I have a Shih Zu and I have been to a few groomers in the area and have not been pleased but...">
The Pet Nanny
Serving Dallas, TX
4.9 Miles
"All I have to say is that it gives you diahreah.When my family ate there we almost had to go...">
Teacup And Toy Pets Boutique
10308 US Highway 80, Dallas, TX 75126
7.8 Miles
"They sell sick and poorly bread puppies, most of them come from first monday trade days.">
Olympus Boerboel Kennels
Dallas, Dallas, TX 75229
11.5 Miles
"We picked our puppy up and he was perfect!! Richard and Michelle walked us through everythin...">
Critter Sitting Services
3425 Coyote Way, Plano, TX 75074
9.8 Miles
"We needed somebody to board our aging Shelty when we went out of town on an emergecy. We cal...">
Pappy's Pet Lodge
471 National Dr, Rockwall, TX 75032
11.6 Miles
"Pappy's Pet Lodge in Rockwall is our Boxer's second home. Harley loves going there and the ...">
Fido's Finest Dog Training
Serving Plano, TX
11.9 Miles
"Casandra & Marne go above and beyond when it comes to our dogs. We started out in priva...">
Clip N DIP Pet SPA
10224 Midway Rd, Dallas, TX 75229
11.5 Miles
"I have taken my dogs to Iris & Lynn for a number of years. My poodle-Chihuahua mix, Bebe...">
Paws Pet Services
3811 Fairmount St, Dallas, TX 75219
12.1 Miles
"I am blessed to have Paws take care of me and my animals (two cats and four dogs). I initial...">
Prestigious Pets Dog Walking And Pet Sitting
3523 Mckinney Ave Ste 724, Dallas, TX 75204
11.4 Miles
"Great company and great rates. ONE FREE VISIT FOR FIRST TIME CUSTOMERS!!">
Used Engines LOW Miles
3965 E Main St, dallas, TX 75217
11.1 Miles
"I bought a part from them , it was good and they were very organized ">
Downtown Dog LLC
2201 S Harwood St, Dallas, TX 75215
12.4 Miles
"This is my dog's favorite place in the whole wide world. They do daycare RIGHT and it is le...">
Society Pet Sitter
Serving Dallas, TX
8.4 Miles
"We have used Society Pet Sitter's services for our dogs since 2001. We have been 100% pleas...">


text:
We pay for the shipping back to our warehouse if you are not fully satisfied. Our Free Return Shipping Offer is unmatched industry wide and a true testament to the confidence in the quality of our furniture. No Re-Stocking Fees, No-Hidden Charges.
Teak Table and Sling Armchairs Dining Set
Understated sophistication and subtle allure unite in the Veranda Apollo 7 piece Dining Set. Made to endure the rigors of the outdoors and changing of the seasons, this dining set will also reside perfectly indoors as well.
The Veranda Appollo Dining set features:
Table built with 100% Grade A Teak harvested from sustainable plantations in Indonesia, every piece is precision manufactured to standard specifications for commercial and residential use. Optional Teak Finishes available.
Chairs made with textilene® a high performance, flame retardant PVC coated sling fabric. UV, tear, and mildew resistant for easy maintenance and cleaning. The strong breathable mesh conforms to the shape of the human body and allows air circulation at all contact points.
As you browse through our pages and speak with our knowledgeable customer representatives, you will find there are quite a few reasons why many have returned and recommended others to shop with us over the past 12 years. Here are some that we often hear why many of our customers think we stand out:
Everything was on time, in tact, and of great quality. A+ customer service.
A very pleasant buying experience.
R M , Melbourne Beach, FL
Assembly Service Notice
Assembly is included with this item when this option is selected. With the assembly option selected, orders that are $1500 or over will also include White Glove Service. White Glove Service, in addition to assembly, includes unpacking, placement of furniture as well as removal and disposal of all debris including cartons and wood crating material. In stock cushions and in stock umbrella fabrics will be included with Assembly/White Glove Services. Made to order cushions and made to order umbrella fabrics are shipped separately via UPS and are not included with Assembly/White Glove Services.
Please allow 2-4 weeks for delivery when choosing Assembly/White Glove Services. Standard, non-assembled, delivery is 2-10 days.
Teak Treatment Service Notice


text:
Texas lawmakers reconvene for new abortion fight - 0 Comments
AUSTIN, Texas — State troopers lined the halls of the Texas Capitol, and 5,000 protesters rallied outside against proposed abortion legislation, as lawmakers convened Monday for a second special session that Republican leaders pledged wouldn't descend into chaos like the first.
The Texas House and Senate each met for less than an hour before recessing for the week. That was just long enough to schedule new committee hearings for the proposed restrictions that would make Texas one of the toughest places in the nation for women to get abortions.


text:
Two British tourists who died after being hit by wave are identified
Mother-of-two Lisa Coggins and her friend Tracey Aston were with three friends and had been posing for pictures on the beach at Lloret de Mar when tragedy struck
Welcome to the new Independent website. We hope you enjoy it and we value your feedback. Please contact us here.
Mother-of-two Lisa Coggins and her friend Tracey Aston were with three friends and had been posing for pictures on the beach at Lloret de Mar when tragedy struck
One question guaranteed not to come up in the leaders' debate tonight is "What will happen to BBC radio under your leadership?" But even if it did, the answer from all three would be so similar that they might as well be reading from the same cue card. Despite testing times ahead, with huge question marks over the licence fee and the scope of the Corporation's activities, the BBC would get the same kidglove treatment as the NHS or the Pope. Gordon Brown would like the BBC "independent" and Nick Clegg wants it "securely funded". Even the Conservatives, who want the licence fee supervised by the National Audit Office and the BBC Trust abolished, talk of a "strong and independent BBC". And no one would mention the World Service, which rarely gets the recognition it deserves, despite being our greatest cultural export after Shakespeare.
Costa Brava tourist board uses Australian beach to fight decline in visitors
The results of a worldwide competition are sharp, satirical – and even funny
Sunday night's triumph in Vienna was a moment of pride, unity and joy for this nation – and a mark of how far it's come. Elizabeth Nash reports from Madrid


text:
A study published today in Science by researchers from the U.S. Department of Energy's Argonne National Laboratory may dramatically shift our understanding of the complex dance of microbes and minerals that takes place in aquifers deep underground. This dance affects groundwater quality, the fate of contaminants in the ground and the emerging science of carbon sequestration.
Deep underground, microbes don't have much access to oxygen. So they have evolved ways to breathe other elements, including solid minerals like iron and sulfur.
The part that interests scientists is that when the microbes breathe solid iron and sulfur, they transform them into highly reactive dissolved ions that are then much more likely to interact with other minerals and dissolved materials in the aquifer. This process can slowly but steadily make dramatic changes to the makeup of the rock, soil and water.
"That means that how these microbes breathe affects what happens to pollutantswhether they travel or stay putas well as groundwater quality," said Ted Flynn, a scientist from Argonne and the Computation Institute at the University of Chicago and the lead author of the study.
About a fifth of the world's population relies on groundwater from aquifers for their drinking water supply, and many more depend on the crops watered by aquifers.
For decades, scientists thought that when iron was present in these types of deep aquifers, microbes who can breathe it would out-compete those who cannot. There's an accepted hierarchy of what microbes prefer to breathe, according to how much energy each reaction can theoretically yield. (Oxygen is considered the best overall, but it is rarely found deep below the surface.)
According to these calculations, of the elements that do show up in these aquifers, breathing iron theoretically provides the most energy to microbes. And iron is frequently among the most abundant minerals in many aquifers, whi
|Contact: Brian Grabowski
DOE/Argonne National Laboratory


text:
Community course designed to teach first aid basics, CPR and use of an AED.
Date: 11/18/2015 to 11/18/2015
Nicklaus Children's is sponsoring the Moving Forward with Patient- and Family-Centered Care: Partnerships for Quality and Safety Intensive Training Seminar on November 2-4, 2015 at the Hilton Tampa Downtown Hotel.
Date: 11/02/2015 to 11/04/2015
Hilton Tampa Downtown
211 N Tampa St.
Tampa, FL 33602
This three day workshop guides you through the Journey to Magnet Excellence®, including a comprehensive overview of the Magnet® Model components and peer review models in nursing.
Date: 10/26/2015 to 10/28/2015
3100 SW 62nd Ave
Miami, Florida 33155
Curso de CPR en Español.
Date: 10/21/2015 to 10/21/2015
Certified American Heart Association instructors from Nicklaus Children's Hospital, will teach Infant, Child and Adult CPR, use of an AED, and First Aid.
Date: 10/13/2015 to 10/13/2015
Time: 08:30 AM to 04:00 PM
Date: 10/06/2015 to 10/06/2015
Knowing how to swim saves lives. Swimming and water safety lessons are offered by a trained instructor for babies as young as 6 months to adolescents up to 21 years.
Join us for group therapy to learn strategies for taking control over your anxiety symptoms. Cope with fears and worries, identify anxiety triggers, learn to relax your mind and body to maximize your self-confidence.
Sibshops is a peer support group for siblings of children with developmental or medical needs. Siblings often find it difficult to express their feelings about their brother or sister with developmental or medical needs to others.
This group therapy program is designed for children ages 7 to 17 with behaviorial issues, including but not limited to ADHD.
Led by Superflex and a group of his comic book friends, this eight week group therapy program is designed for children ages 7 to 12 who have been diagnosed on the autism spectrum. Superflex: A Superhero Social Thinking Program provides a cognitive-behavioral curriculum to help children become aware of themselves and their social behaviors.


text:
Aug 12, 2015 Bob Buskirk All News, Hardware News 0
Intel has just launched their enthusiast desktop Skylake processor, but they are not done with Skylake. The upcoming Skylake-U low-power processors are made for ultra-portable notebooks, tablets, convertibles, and fan-less desktops. These dual-core chips will extend through five brand extensions – Core i7, Core i5, Core i3, Pentium, and Celeron.
Jul 02, 2015 Bob Buskirk All News, Hardware News 0
ASUS has just introduced two new mini-ITX motherboards that are based on the Intel quad-core N3150 and N3050 SoCs. These two new boards are the N3150-C and N3050C and feature SoC's that are based on the Baswell silicon that features embedded quad-core or dual-core CPUs based on the 64-bit x86 Airmont CPU micro-architecture.
May 19, 2015 Bob Buskirk All News, Hardware News 0
ASUS has just rolled out a new value Micro-ATX motherboard in their N3150M-E. It is based on the new Intel Celeron N3150 SoC "Braswell." This 14nm SoC has a quad-core CPU based on the "Airmont" architecture, an integrated GPU with 12 execution units, and a dual-channel DDR3L-1600 memory controller.
Feb 04, 2014 Bob Buskirk All News, Hardware News 0
Gigabyte has just announced the J1800N-D2H Mini-ITX motherboard. With this release they join a number of companies offering Bay Trail D compatible motherboards. This board features Intel's Celeron J1800, which belongs to the Bay Trail D family. It uses the Celeron brand name and is part of the Silvermont architecture. This low-powered SoC is designed for small systems such as HTPC setups.
Jan 24, 2014 Bob Buskirk All News, Hardware News 0
Intel will soon be rolling out a new NUC form-factor system based on the Atom "Bay Trail" SoC. The product name is the NUC DN2820FYKH and it will run a Celeron N2820 SoC, which is a dual-core 64-bit x86 CPU clocked at 2.4 GHz and a TDP of under 7.5W.
Dec 30, 2013 Ahmed Humayun All News, Hardware News 0
This act saw a price cut that ranged from 4% to 26% and was done for approximately 31 processors by Intel, majority of which were the mobile models. The Core i7-4770R, i5-4670R and i5-4570R were the three low-power Haswell-based chips and these were the only desktop chips which received a cut somewhere between 9% and 11%.
Dec 27, 2013 Ahmed Humayun All News, Hardware News 0
It was known that the Haswell 'Celeron' Processors will not be launched till the first quarter of 2014 but Intel has already rolled out two SKUs ahead of the launch date. While these two are available for purchase already, the other will be available next month.
Sep 02, 2013 Ahmed Humayun All News, Hardware News 0
Intel has now introduced its new range of desktop processors with the new models of Ivy Bridge and Haswell. With this expansion of new processors, Intel seemingly wishes to spread out the availability of its processors to additional markets. The new Haswell processors include the variation of the Core i7.
Jul 17, 2013 Ahmed Humayun All News, Hardware News 0
In spite of the fact that Haswell that is considered to be Intel's latest consumer platform; Intel is still seeking to keep Ivy Bridge and LGA 1155 intact with some more CPU releases. Intel plans to release four new CPUs in the near future which include two Core i5 and two Celeron models.
Jul 09, 2013 Ahmed Humayun All News, Hardware News 0
Intel's first processor in the BGA package is expected to arrive by the end of this year, according to one of the leaked roadmap slides. Among the first few processors will cover across entry-level market sector, including the Celeron and Pentium brands. Motherboards with BGA processors come with the processors that cannot be the replaced and are hard-wired to the board along with a stock fan-heatsink. The SOC completely put together the processor as far as we know it, with the motherboard chipset.
Oct 02, 2015 0
Oct 02, 2015 0
Oct 02, 2015 0
Oct 01, 2015 0
Oct 01, 2015 1
Sep 29, 2015 0
Sep 24, 2015 0
Sep 21, 2015 0
Sep 16, 2015 0


text:
|Numéro de publication
|Type de publication
|Numéro de demande
|Date de publication
|11 sept. 2001
|Date de dépôt
|26 mars 1999
|Date de priorité
|14 nov. 1995
|État de paiement des frais
|Autre référence de publication
|Numéro de publication
|Andrew J. Croteau, Mark W. Pierson, David E. Townsend, Ali Naqui
|Cessionnaire d'origine
|Biocontrol Systems, Inc.
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Citations de brevets (45), Citations hors brevets (24), Référencé par (13), Classifications (18), Événements juridiques (7)
|Liens externes: USPTO, Cession USPTO, Espacenet
This application is a continuation of U.S. Ser. No. 08/746,054, filed Nov. 6, 1996, now U.S. Pat. No. 5,985,594, which is a continuation-in-part of Croteau et al., U.S. Ser. No. 08/606,229, filed Feb. 23, 1996, now U.S. Pat. No. 5,700,655, which is a continuation-in-part of Croteau et al., U.S. Serial No. 08/557,529, filed Nov. 14, 1995 now abandoned, all entitled "Method for Quantification of Biological Material in a Sample" hereby incorporated herein by reference, including drawings.
This invention relates to a method for quantification of biological material in a sample.
Many industries need to detect and quantify the concentration and level of biological material in a sample. For example, the determination of bacterial concentration in food and water is an essential part of food and water quality testing. EPA regulations require that no Coliform such as Escherichia coli can be present in potable water. The "presence/absence" format of a testing medium, such as Colilert® chemical mixture (IDEXX Laboratories, ME) which is used as a testing medium for Escherichia coli and all coliform bacteria, is very useful in making this determination. Colilert® chemical mixture is based on the Defined Substrate Technology described in Edberg, "Method and Medium for use in Detecting Target Microbes In Situ in A Specimen Sample of A Possibly Contaminated Material," U.S. Pat. Nos. 4,925,789 and 5,492,933. See also, Townsend et al., U.S. Ser. No. 08/484,593 filed Jun. 7, 1995 entitled, "Method and Composition for Detecting Bacterial Contamination in Food Products", hereby incorporated by reference herein, describes a medium for the detection of bacteria in food and water samples.
However, there are areas where the quantification, not just the detection, of bacterial concentration is important. Examples of such areas include waste water, incoming water in water purification systems, surface water, and food testing. For example, numerous restaurant chains will only accept raw ground beef or poultry that contains less than a certain concentration of bacterial contamination. Therefore, food processing plants must carry out the necessary microbiological tests to determine the bacterial concentration of these food items before they can be released to customers.
The classical methods of quantification of biological material are the standard plate count method or the multiple tube fermentation (MTF) method. A quantity of sample being tested for microbial contamination is first dispensed in a Petri dish. Then 15 ml of the appropriate media is poured over the sample. The Petri-dish is then swirled to mix the sample in the medium and the Petri-dish is left to solidify at room temperature for approximately 20 minutes. The medium is then incubated at a specific temperature for a specific time, and any resulting colonies are counted.
The multiple tube fermentation method is described in Recles et al., "Most Probable Number Techniques" published in "Compendium of Methods for the Microbiological Examination of Foods", 3rd ed. 1992, at pages 105-199, and in Greenberg et al., "Standard Methods For the Examination of Water and Wastewater" 8th ed. 1992). In this method, a volume of sample is dispensed into several tubes representing this dilution range. The tubes are then incubated at the appropriate temperature so that the bacteria in each tube are allowed to grow. After incubation at a specific temperature for a specific time, the number of positive tubes is counted. The most probable number can be determined from the formula described in Recles et al., supra.
Water testing is mostly done by membrane filtration, where a certain volume of water is passed through the membrane and the membrane is incubated in a medium for a certain period of time. After appropriate incubation, the colonies are counted.
The present invention provides a simple method for more accurate quantification of the number of microorganism in a sample, or for quantification of any other type of discrete particulate biological material within a sample. Such biological materials include fungi or other living organisms, as well as aggregates of proteins, such as enzymes, or even co-factors, using reaction mixtures well known to those in the art. The invention generally makes use of a novel article which is designed to hold a liquid sample in which chemical and/or microbiological reactants are provided. For example, such chemical reactants may be a specific growth medium for bacteria. The device used is generally in the form of an incubation plate having a multitude of wells able to hold separate aliquots of liquid. Generally, the device is designed to hold between 5 and 100 ml of liquid in total, and the wells are designed to form separate incubation chambers for each aliquot of sample. The wells can be of same size or of different size and shape to increase counting range and/or simulate dilution effects. See, Naqui et al., U.S. Ser. No. 08/201,110, filed Feb. 23, 1994, entitled "Apparatus and Method for Quantification of Biological Material in a Liquid Sample", incorporated by reference herein.
Thus, in a first aspect the invention features a method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample and reagent into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquified sample is poured from the surface of the plate due to the hydrophobicity of the material used to form the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined. In a preferred embodiments the wells are chamfered to allow liquid, that is above the horizontal plane, to be poured off easily (see FIG. 3).
As noted above, the biological material that can be detected is any material that forms a discrete particle, such as a microorganism, which may be quantified by determining the presence or absence of such a biological material within each well of the incubation plate. The sample may be any biological sample or environmental sample such as waste water, food, a surface swab, or swabs from other surfaces, such as a throat, or other samples well known to those in the art. This sample may be-a liquid sample, or may be dissolved in a liquid to form the liquified sample. Thus, the term "liquifying" in the above paragraph refers to providing the sample in a liquid that once combined with a microbiological reagent can be rapidly aliquoted within the incubation plate. The liquified sample may remain as a liquid or may be solidified in the wells.
The incubation plate may be formed of any desired material, but in particular it is desirable that a plastic be used which allows separate aliquots of the liquified sample to be held by surface tension within each well without cross contamination of the wells. Preferably, the material is hydrophobic. The surface can be untreated or treated chemically or physically to enhance retention of liquid witning the wells.
The shape of the incubation plate is not relevant, and in preferred embodiments is a generally circular shape (such as that of a Petri dish). Indeed, the incubation plate can be used to take the place of a Petri dish. Specifically, the method of this invention can be used to replace those existing tests that are generally run on Petri dishes to score the number of bacterial colonies. Since discrete aliquots of the sample are provided in the plate, one of ordinary skill in the art need only score the number of positive wells in the plate to define the quantity of biological material within the original sample, as with-the MPN test discussed above.
The generally flat horizontal surface is designed to allow the liquid to be aliquoted readily between the wells and then excess liquid to be poured from the plate. In a preferred embodiment, a lip or pouring spout is provided for the plate. Those in the art will recognize that the depth and shape of the wells, as well as the material used to make the wells and the plate, are chosen such that surface tension can be used to hold the aliquots within each well dependent on the type of the liquid used in the liquified sample.
In other preferred embodiments, the surface defines at least 40, 60, 80 or even 200 or more recessed wells; the plate is formed of any formable plastic; a lid is also provided to prevent contamination of liquid within the wells; and the plate is provided in a sterile form so that no positive aliquots are noted unless at least one biological material particle is present in the sample.
In yet other preferred embodiments, the incubation plate is clear or colored, for example, white or yellow (to enhance the appearance of color (e.g., blue)) within the incubation plate) and the well has a diameter of about 0.15 inches, and the plate a diameter of about 3 or 5 inches.
In still other preferred embodiments, the incubation plate has a "pour-off pocket" adjacent to the surface of the plate. The pocket has sufficient capacity to contain the excess liquid to be removed from the plate surface. As an aid in preventing the excess fluid from spilling back onto the plate surface, it is preferable that the pocket contain an absorbent material, e.g., a gauze-like material. In a particular embodiment, the plate has both a pour-off pocket and a "landing pad". The "landing pad" is described below.
In a related aspect, the invention features a sterile incubation plate having a generally flat horizontal surface. The-surface defines a plurality of at least 20 recessed wells (in preferred embodiments, at least 40, 60, 90 or even 200 recessed wells are provided) and each well is adapted as described above to hold aliquots of liquid by surface tension.
In preferred embodiments, the invention features the sterile incubation plate much as described above but having incorporated therein a "landing pad", which is a generally central area of the plate lacking wells, which can receive the sample prior to that sample being diluted in, for example, an incubation medium. Thus, a volume of 0.01 to 5 ml of sample liquid may be applied in the "landing pad" area (depending on its size and shape) and then that liquid dispensed into each well by applying the diluent and growth supporting medium (e.g., the Colilert™ chemical mixtures noted above) and that liquid will simultaneously dilute the sample and allow dispersion of the sample throughout the wells.
In addition, a pour spout can be provided within the incubation plate to allow pouring-off excess liquid within the plate. Such a pour spout can be matched with a suitable lid having a slit which allows liquid in the incubation plate to be poured from the incubation plate only when the slit is lined up with the pour spout, as described below.
As indicated for the method above, the incubation plate may also have a "pour-off pocket" adjacent to the surface of the plate. The pocket has sufficient capacity to contain the excess liquid to be removed from the plate surface, and preferably the pocket contains an absorbent material, e.g., a gauze-like material. In a particular embodiment, the plate has both a "pour-off pocket" and a "landing pad".
Applicant provides an extremely useful method which allows unskilled personnel to rapidly determine the quantity of biological material within a sample. Since the sample is readily liquified by people without significant training in microbiology, and the materials for any specific tests can be provided by the manufacturer, such people can readily perform the tests with accuracy. The incubation plate is generally provided in the sterile form so that no inappropriate detection of biological material can occur.
While it is known to provide plastic containers which can hold liquid within a plurality of recesses, applicant believes that this device provides a new automatic aliquoting method. This is an improvement over the existing products used to detect and quantify microorganisms because the liquid migrates to the individual wells without individual dispensing.
The present device can replace the use of a Petri dish and can be used particularly in food analysis and in testing of clinical samples. The separation of the wells of the present device prevents crosstalk or contamination between each aliquot. Because of this, many of the tests can be performed by observing fluorescence (which is not readily performed in an agar-containing Petri dish). The device is particularly useful when there is a large quantity of microorganisms present in a sample, such as more than one organism per one ml or per ten ml.
Other features and advantages of the invention will be apparent from the following description of the preferred embodiments thereof, and from the claims.
The drawing will first briefly be described.
FIGS. 1 and 2 are diagrammatic representations of a formed plastic incubation plate.
FIG. 3 shows a cross section of a well, with or without a chamfer.
FIG. 4 is a diagrammatic representation of a formed plastic incubation plate having a pour spout and corresponding slit as well as a "landing pad".
FIG. 5 is a diagrammatic representation of a formed plastic incubation plate having a "landing pad" and a "pour-off pocket".
Referring to FIGS. 1 and 2 there is shown an incubation plate 10 having a plurality of wells 12 each having a diameter of about 0.16 inches. The incubation plate 10 has a diameter of about 5 inches. The incubation plate is made of formed plastic. Wells 12 are spaced apart sufficiently to prevent crosstalk between the wells. These wells may have a chamfer (FIG. 3) if desired to prevent liquid remaining at the upper edge of the well. Those in the art will recognize that incubation plate 10 can be readily formed by standard procedure and manufactured in the general shape of a Petri dish, with or without a lip or pouring spout, and with or without a lid 14. This lid is provided with a dimple 16 to prevent contact of the lid with plate 10.
Referring to FIG. 4, there is shown in incubation plate 10 having a plurality of wells much as described above. The incubation plate also includes a "landing pad" 22 of size about one and one-half inch diameter which is simply an area able to hold a defined volume of liquid. Within the incubation plate is also is provided a pour spout 24 which allows excess liquid to be removed from the incubation plate. Also provided is a corresponding lid 14 having a slit which can be matched with the pour spout to allow liquid to be removed from the incubation plate. When the slit is not aligned with the pour spout, evaporation of liquid within the plate is decreased by reducing air flow over the liquid in the wells. A dimple 16 may also be provided in the lid to prevent the lid surface contacting the wells and thus preventing cross contamination between the wells.
Referring to FIG. 5, there is shown an incubation plate 10 having a plurality of wells much as described above, which also includes a "landing pad" 22 of size about one inch diameter. Within the incubation plate is also provided a "pour-off pocket" 26 adjacent to the surface of the plate which allows excess liquid to be removed from the incubation plate. As shown in the cross-sectional view, the "pour-off pocket" is formed by an elevated barrier 28 between the pocket and the plate surface. The barrier has a lower barrier section 30, which serves as a channel through which the excess fluid from the plate surface may be poured into the pocket. Typically, the pocket will contain an absorbent material which will retain the fluid within the pocket, preventing back spill onto the plate surface.
In use, a reagent powder suitable for detection of a biological material can be rehydrated with an appropriate amount of sterile liquid and then inoculated with a known volume of a test sample. For example, 20 ml of sterile water can be inoculated with between 10 and 1,000 microliter of sample. The inoculated reagent can then be added to-incubation plate 10 and that liquid swirled within incubation plate 10 to distribute the inoculated liquid reagent to each of wells 12. Incubation plate 10 is then held at an angle of approximately 90 degrees to allow excess inoculated liquid reagent to be removed from the plate. A lid may then be placed on the incubation plate and that plate held in an incubator for the appropriate length of time, for example 18-48 hours. After that length of time, the presence or absence of a positive result can be scored in each well 12 of the plate. In addition, for plates having a "pour-off pocket", due to the larger volume of fluid contained in the pocket, a positive result in the pocket can serve as an early indication of high bacterial counts.
For total plate count a plate as described above is used for the detection and quantification of the total bacterial concentration of food. It is based on a Multiple Enzyme Technology (Townsend and Chen, Method and Composition for Detecting Bacterial Contamination in Food Products, U.S. Ser. No. 08/484,593 hereby incorporated by reference herein) which correlates enzyme activity to the presence of viable bacteria in food. It utilizes multiple enzyme substrates that produce a blue fluorescent color when metabolized by bacteria. When the liquid reagent is inoculated with a prepared food sample and-dispensed into a plate as described herein the total viable bacterial concentration of that food product can be determined after 24 hours of incubation. The actual medium used herein is not critical to the invention, but is provided only for illustrative purposes.
Storage and Disposal
Store bulk powder and unused Simplates at room temperature (4 to 25° C.) away from the light. After use, the Simplate device will contain viable bacteria which must be handled and discarded appropriately. Once the powder is rehydrated it is stable for up to 24 hours when stored at 4 to 25° C.
Test Procedure
1. Pour an appropriate amount of bulk powder to a container of sterile deionized water. One vial contains enough powder for 10 tests. Each test has a final volume of 10 ml. For example: add 1 vial of powder to 100 ml of sterile water to make enough media for 10 tests.
2. Place test sample on the center "landing pad" 22 of the plate 10 shown in FIG. 4. At the completion of this procedure half of the test sample will be poured off and discarded, therefore, the size of the inoculum must take this into account. For example, if you wish to measure the bacterial concentration of 0.1 ml of test sample then you must place 0.2 ml of test sample on the "landing pad". Place no more than 2 ml on the center "landing pad".
3. Remove the lid from the plate and dispense 10 ml of TPC media in the plate making sure to direct the liquid over the test sample on the center "landing pad". If the test sample is greater than 0.1 ml add enough TPC to achieve a final volume of 10 ml in the plate. Note, if the liquid is not dispensed on the "landing pad" it may splatter.
4. Place the lid back on the plate. Note, to ensure that the liquid remains in the Simplate make sure that the slit on the lid is not lined up with the pour spout.
5. Distribute the liquid into the wells by swirling the plate as you would a standard pour plate.
6. Line up the slit on the lid with the pour spout and carefully pour off the excess liquid that did not end up in the wells. Holding the plate at an angle of approximately 90° from the work bench ensures proper pour off of excess liquid. Make sure that all liquid "cross bridges" between wells are removed by gently tapping the plate. Dispose of excess liquid appropriately.
7. Slide the lid away from the pour spout to avoid drying the liquid in the wells during incubation and to avoid contamination from outside through the opening.
8. Place the plate in an incubator for 24 hours. Plates can be inverted if desired. Incubation temperatures greater than 37° C. are not recommended.
9. Count the number of fluorescent wells after 24 hours by placing a 6 watt 36 nm UV light within five inches of the plate. Do not read plate before 24 hours. Results are stable to 48 hours.
10. Compare the number of fluorescent wells to an MPN chart to determine the most probable number of bacterial present in the plate.
1. Pour an appropriate amount of bulk powder to a container of sterile deionized water. One vial contains enough powder for 10 tests. Each test has a final volume of 10 ml. For example: add 1 vial of powder to 100 ml of sterile water to make enough media for 10 tests.
2. Place test sample on the center "landing pad" 22 of the plate 10 shown in FIG. 5. At the completion of this procedure half of the test sample will be poured off into the pocket, therefore, the size of the inoculum must take this into account. For example, if you wish to measure the bacterial concentration of 0.1 ml of test sample then you must place 0.2 ml of test sample on the "landing pad". Place no more than 2 ml on the center "landing pad".
3. Remove the lid from the plate and dispense 10 ml of media in the plate making sure to direct the liquid over the test sample on the center "landing pad". If the test sample is greater than 0.1 ml add enough media to achieve a final volume of 10 ml in the plate. Note, if the liquid is not dispensed on the "landing pad" it may splatter.
4. Distribute the liquid into the wells by swirling the plate as you would a standard pour plate, taking care that the fluid does not enter the "pour-off pocket".
5. Carefully pour off the excess liquid that did not end up in the wells through the "pour-off pocket" barrier channel. Holding the plate at an angle of approximately 90° from the work bench ensures proper pour off of excess liquid. Make sure that all liquid "cross bridges" between wells are removed by gently tapping the plate.
6. Place the plate in an incubator for 24 hours. Plates can be inverted if desired if the "pour-off" pocket contains an absorbent material.
7. Count the number of fluorescent wells after 24 hours by placing a 6 watt 36 nm UV light within five inches of the plate. Do not read plate before 24 hours. Results are stable to 48 hours.
8. Compare the number of fluorescent wells to an MPN chart to determine the most probable number of bacterial present in the plate.
The plate and media described in Example 1 are used for this test.
Test Procedure
1. Add 10 ml of sterile water to the tube of predispensed powder. If greater than 0.1 ml of food sample is to be inoculated into the test, reduce the volume of sterile water appropriately to achieve a final volume of 10 ml in the tube.
2. Inoculate the liquid reagent with the food sample being tested.
3. Shake tube several times to completely mix powder and inoculated food sample. Avoid excessive mixing which tends to foam up liquid reagent. Too much foam can complicate the distribution of the liquid into the plate. The rest of the procedure is as in Example 1.
Other embodiments are within the following claims.
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|Classification aux États-Unis
|435/30, 435/29, 435/4
|Classification internationale
|Classification coopérative
|Classification européenne
|5 mai 2000
|31 janv. 2005
|Fee payment
Year of fee payment: 4
|1 juin 2005
Owner name: PUGET SOUND BANK, WASHINGTON
Free format text: SECURITY INTEREST;ASSIGNOR:BIOCONTROL SYSTEMS, INC.;REEL/FRAME:016290/0595
Effective date: 20050527
|31 aoűt 2007
Owner name: PUGET SOUND BANK, WASHINGTON
Free format text: SECURITY AGREEMENT;ASSIGNOR:BIOCONTROL SYSTEMS INC.;REEL/FRAME:019767/0787
Effective date: 20070830
|11 mars 2009
|Fee payment
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Owner name: U.S. BANK NATIONAL ASSOCIATION, WASHINGTON
Free format text: SECURITY AGREEMENT;ASSIGNOR:BIOCONTROL SYSTEMS, INC.;REEL/FRAME:030666/0291
Effective date: 20130620


text:
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Set of folded stationery cards printed on bright white, smooth card stock to bring your personal artistic style to everyday correspondence. Each card is blank on the inside and includes a soft white, European fold envelope for mailing.
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Compact simplex system -designed for residential sewage applications.
Perfect for basement bathroom additions and remodeling projects.
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US Patents# 7,520,736# 7,563,082# 7,159,806# 8,523,532


text:
Friday, 9 October 2015
Last updated 1 hour ago
Nov 15 2012 | 12:31pm ET
Bank of America's investment bankers have been ordered to meet in person with their hedge fund clients and others at least 20 times a month, as the firm seeks to bring in more revenue from trading.
The order went out in September from global equities distribution chief Soofian Zuberi, who told his 500 sales employees that more face time would help them better understand their clients' needs. Specialty equities sales staffers, including derivatives and prime brokerage team members, were ordered to meet in person with clients at least 30 times a month—or 1.5 meetings per business day—while those assigned to hedge fund and mutual fund traders were told to hold at least 20 meetings a month.
Meetings statistics will be posted internally, and those who fail to hit required numbers will have to deal with their managers at the end of the year.
The new order has led to serious grumbling at BofA, Bloomberg News reports, and, coming in advance of bonus season, has led some employees to exaggerate their meeting logs. And, of course, it's led to much unhappiness, as salesmen assigned to traders in particular complain that they usually stay parked at their desks during trading hours. Others complain that, at the same time Zuberi issued his order, BofA, in a cost-cutting move, has made a bigger issue of employees sticking within entertainment guidelines that limit them to spending $150 per person for dinner, $75 for lunch and $30 for breakfast. Those who exceed those limits have been asked to reimburse the bank, Bloomberg reports.
And to what end? Possibly not much, according to one hedge fund manager.
"It's not the number of meetings, it's sitting there and coming up with a compelling idea that makes me want to feed you that commission," QAM's Sarah Quinlan told Bloomberg Television. "You will be out with the clients who don't actually have any money to spend; you'll find the dead body down the street and say, 'Let's go do dinner.'"
Oct 5 2015 | 8:17pm ET
Hedge fund administration has evolved from simple record keeping to an integral,...
Oct 8 2015 | 10:14pm ET
Billionaire hedge fund manager Ken Griffin and his wife have settled a long-running...
Sep 30 2015 | 1:56pm ET
In this contributed article, Bruce Frumerman of Frumerman & Nemeth Inc. explains...
Oct 7 2015 | 4:57am ET
Charity A Leg To Stand On (ALTSO) will hold its 12th Annual Hedge Fund Rocktoberfest – NYC on October 15 and its 4th Annual Rocktoberfest - Chicago on October 22. Read more…


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Spalding Pro Image Rim - Color: Red
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Morningstar analysts cover more than 300 ETFs. Below is a sample Analyst Report for another ETF, DGS.
WisdomTree Emerging Markets SmCp Div ETF
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ETF Research and Analysis
by Patricia Oey
WisdomTree Emerging Markets SmallCap Dividend DGS holds dividend-paying emerging-markets small-caps. While this is an index fund, it is not market-cap weighted, instead, holdings are weighted by dividends paid. This fund
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Bull Case
Small-cap firms tend to have good exposure to domestic growth trends.
Emerging-markets small-cap funds are generally not more volatile than their large-cap fund peers.
Long-term growth drivers for many companies in this fund include infrastructure spending and a rising middle class.
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Bear Case
Emerging-markets equities can be volatile during periods of high uncertainty in global markets.
Record-low interest rates in the developed world have helped drive strong investment flows into emerging markets. A sudden outflow may result in short-term volatility in emerging-markets currencies and asset prices.
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Kinniry: A Double Hurdle for Tactical Asset Allocation
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Population: 1449Total Males: 718
Total Females: 731
Median Household Income: $ 42024
Total Households: 612
Full U.S. census data is available here.
Business Industries in Waverly
Below is a list of the types of businesses in the City of Waverly for which we have Yellow Pages business listings. If you do not see your industry within the list below, adding your business will automatically create it.
Brief Information About Waverly
This small city of Waverly is based in Morgan County of Illinois, USA. The leading economic activities include accounting, dealership, banking, brake services, consulting, cleaning, and courier and delivery services, financing, supplying, insurance, mortgage, real estate and hospitality and education.
Mainly white populated region, Waverly has few Native American and Hispanics as well.It has night clubs, coffee shops, groceries, supermarkets, take outs and convenience centers.
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