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Jan 2014........GONE
Listen, dave.. all you post on is rsh.... this means you are obsessed with the stock... beyond some normal investment ... it is so obvious you are a disgruntled former employee.., fired ..... let go..... how childish is it to hawk yourself on an anonymous board to feel some form of significance or gratification... for being FIRED...
you are right...I am obsessed with rsh.......been so since 14 bucks.........been wonderful.... seen and dispatched so many like you aver the last years.......been very enjoyable actually. i get such a charge out of rookie investors like yourself that focus on the posters and not your joke of a broken stock.....i totally and completely own you and control your every move...come on puppet.....post some thing sharp for us......so fun when you attempt to post zingers when in 60 days or so RSH will post another dismal quarter adding more of you money into my account. come on puppet.....give us some witty posts........lol
Why shouldn't Dave gloat? Most of the people fired or run out of RS were highly competent employees with years of valuable experience. And look what is left? So who turned out to be right in the end? The title alone of this thread says it all. Down, down, down.
i bet Dave's wishes he could win the Lotto, wait until the stock reaches $.15 or so, buy a controlling interest in the company, and then fire every one of the fools that came in with Day and Bevens with a YouTube video showing who they were and how they ruined a former major icon in the consumer electronics business.
Something that is not understood by certain people here is that the former long term employees of the company had a relationship that is rarely seen today. They, not Fort Worth, were the ones who made RS the success that it once was. They were the ones who often opened early and stayed late, off the clock. They were the ones who knew a wealth of information regarding everything from resistors to hard drives to the proper type of battery for a watch.
Few people are aware of how many items this company actually sells and the time it takes to truly learn the inventory and how different things in the stores are used and can relate to one another. To many a former manager these stories were like a second home or a wife. It was their lives and they gave it everything they had. To leave with honor is one thing but to leave with a boot print on your back and insults of how you are no longer of any value is another. I don't blame these people for their attitudes at all. They were right and the current management style over the last 7 years or so has destroyed the company.
What will you do with your life at that point?? Start a 'fired rsh employees' chat room to reminisce?? You formers are obvious and pathetic.. true losers...
You left out rich............Hows that lil ceasars pizza job working out? poster just driving you nuts..least you have something to focus on..your stocks a stinky stinky


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Total Reviews
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Bought a new Escape 2.0L SEL and quite happy with it. Didn't get Nav or sunroof. Good visibility and great to drive. Only got 2500 miles on it and recently got 30 miles to the gallon.
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Cliche-ridden horror scenes fail to deliver
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OPINION: MOVIE REVIEW: Deliver Us From Evil. Starring Eric Bana, Edgar Ramirez, Olivia Munn and Sean Harris; directed by Scott Derrickson
Watching the trailer for Deliver Us From Evil had me excited.
A cop teams up with a priest to banish an evil spirit, and the soundtrack includes songs from The Doors.
The film was based on true events in the book Beware the Night, written by Ralph Sarchie, also the main character in the movie.
What should have been a great blend of crime and horror genres was actually an assembly of clumsy cliches.
Main character Ralph Sarchie (Eric Bana), a street cop with anger problems who doesn't spend enough time at home, meets Mendoza (Edgar Ramirez), a once troubled teenager with a drug problem who turned to priesthood for redemption.
The pair work together to chase down former marine Santino (Sean Harris) who fought in Iraq, and became possessed by a demon during the conflict, who targets Sarchie's family.
While there were some big fright moments as you would expect from a horror flick, I found myself rolling my eyes at stupid stereotypes like creepy children's toys and the fact that the entire film was filmed at night or in the dark.
I also questioned why Sarchie's partner Butler (Joel McHale) was a cop who fought with switchblades.
The screenwriter had possessed characters mumbling lyrics from The Doors' songs, and I was waiting for it to be tied into the plot somehow, but I left the theatre confused as to how an Iraqi demon would know the lyrics.
Less than an hour after leaving the theatre, I struggled to remember characters' names or even the title of the movie I'd just watched.
I must admit, I am something of a die-hard horror fan, and I'm always looking for something original.
I overheard two teenage girls who sat in the row behind me saying it was one of the best horror flicks they've seen.
But for me, it was a completely unmemorable watch.
- The Southland Times
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Sam's Town Tunica
1477 Casino Strip Resorts Blvd., 38664 Robinsonville, MS, US
Near Tunica Queen Riverboat
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Located in Robinsonville, Sam's Town Tunica is close to Tunica River Park and Tunica Queen Riverboat. This casino resort is within the region of Tunica National Golf Course and Tunica Arena and Exposition Center.Dining info:
Enjoy a meal at a restaurant or in a coffee shop/café. Or stay in and take advantage of the resort's room service (during limited hours). Quench your thirst with your favorite drink at a bar/lounge. Breakfast is available for a fee.Amenities info:
Take time to pamper yourself with a visit to the full-service spa. After enjoying recreational amenities such as a spa tub and a sauna, a lucky night at the casino is the perfect end to the day. This resort also features complimentary wireless Internet access, concierge services, and an arcade/game room.Business amenities info:
Featured amenities include express check-in, express check-out, and dry cleaning/laundry services. Event facilities at this resort consist of conference space and meeting rooms. Free valet parking is available onsite.Room detail info:
Make yourself at home in one of the 841 guestrooms. Cable television is provided for your entertainment. Bathrooms feature shower/tub combinations, complimentary toiletries, and hair dryers. Conveniences include desks and coffee/tea makers, and housekeeping is provided daily.Know before you go info:
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Standard room - Main Tower
- Blackout drapes/curtains
- Cable TV service
- Climate control
- Coffee/tea maker
- Connecting/adjoining rooms available
- Cribs/infant beds available
- Daily housekeeping
- Desk
- Free toiletries
- Hair dryer
- Iron/ironing board (on request)
- Pay movies
- Refrigerator (on request)
- Rollaway/extra beds available
- Room service (limited hours)
- Shower/tub combination
|Check In & Check Out
|Internet Access
|Food & Drink
|Things To Do
|Business Facilities
|Wellness & Spa
Tunica, MS (UTM-Tunica Municipal) - 15.7 km / 9.8 mi
Memphis, TN (MEM-Memphis Intl.) - 46.8 km / 29.1 mi
The preferred airport for Sam's Town Tunica is Memphis, TN (MEM-Memphis Intl.).
Distances are calculated in a straight line from the property's location to the point of interest or airport and may not reflect actual travel distance.
Distances are displayed to the nearest 0.1 mile and kilometre.


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Friendly staff in the SPA and cleaning people are nice.
wifi doesn't work in the rooms. Was able to get decent connection only next to the lobby cafe.
Rooms are outdated, water pressure and shower design are bad.
Old balcony doors, hard to close. Tiny outdated TV, it's better not to have a TV at all.
Bad is outdated. Very hard for a couple to sleep on 2 twin beds put next to each other.
Wasn't easy to control room temperature.
The hotel is not on the beach as advertised. They charge extra 5 euro to use the beach even though you are already a hotel guest.
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For the latest leak off Statik Selektah's Popular Control, Mac Miller and R&B singer Josh Xantus spread the groupie love. Cop the track on iTunes. Album in stores October 25.
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October 18, 2011 @ 8:44 AM EDT General
October 18, 2011 @ 8:33 AM EDT General
Jay-Z!! Hov lends his voice as a business mogul
October 18, 2011 @ 8:13 AM EDT General
In support of the American Cancer Society, Big K.R.I.T., Outasight and
October 18, 2011 @ 8:11 AM EDT General
Still skating to one song, one song only is the Throne's Hit-Boy-produced track. And as a Halloween treat, Breezy and T-Peezy are just the latest ones to hop on the instrumental.
October 17, 2011 @ 10:03 PM EDT Mixtapes
We got a leak from the project this weekend but now Don Cannon & Estelle give us the tape in its entirety. Tracklist and download link after the cut.
October 17, 2011 @ 9:55 PM EDT General
It's been a very long wait for T-Pizzle's album but it looks like we will finally be getting it this winter. He tweeted the album cover and says, expect to see rEVOLVEr on December 6th.
October 17, 2011 @ 9:31 PM EDT General
Fuck that! BeYoung, Like and Mibbs all display their special technique over GZA's classic tune. Off


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Paul Sewald 18 P
Binghamton Mets
- Double-A | Eastern League
- MLB Parent Club: New York Mets
- Status: Active
- Full Name: Paul Stanton Sewald
- Age: 25 (May 26, 1990)
- Birthplace: Las Vegas, NV
- Bats/Throws: R/R Ht: 6' 2" Wt: 190
- Draft: Round 10 (2012, NYM)
- School: San Diego
Paul Sewald Career Stats
MiLB.com News
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|July 21, 2015
|Binghamton Mets activated RHP Paul Sewald from the temporarily inactive list.
|July 4, 2015
|Binghamton Mets placed RHP Paul Sewald on the temporarily inactive list.
|August 25, 2014
|RHP Paul Sewald assigned to Binghamton Mets from St. Lucie Mets.
|April 3, 2014
|RHP Paul Sewald assigned to St. Lucie Mets from Savannah Sand Gnats.
|May 15, 2013
|Savannah Sand Gnats activated RHP Paul Sewald from the 7-day disabled list.
|April 10, 2013
|Savannah Sand Gnats placed RHP Paul Sewald on the 7-day disabled list. contusion
|April 3, 2013
|RHP Paul Sewald assigned to Savannah Sand Gnats from Brooklyn Cyclones.
|June 16, 2012
|Paul Sewald assigned to Brooklyn Cyclones.
|June 15, 2012
|New York Mets signed RHP Paul Sewald.


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Let us help you wow your Passover crowd with our chef-prepared entrees and sides. Just heat, serve, and enjoy the compliments.
From our Seder plate and tasty tzimmes to matzo meal and pantry essentials, find just what you need to bring your Passover together.
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Hozier – Jackie And Wilson | Video
Click here to watch Hozier in his new video.
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Lana Del Rey is back with new record Honeymoon. Check out our review to see if it's worth a listen!
Do we really need a sequel to Mary Poppins?
A Destiny's Child comeback on the cards? Here are reasons why it should happen!
Click here to watch Tyler the Creator's new video Buffalo.
Time to party at the fairground!
Need some inspiration for your next 'Netflix and chill' session? Try these music films. They may not get you action but you'll be glued to the screen!
Anyone but these people please!
Time to get the turntable out the loft?
The haunting voice of Lana Del Rey comes to life in her new video Music To Watch Boys To.
Is Fetty Wap more than a one hit wonder? Find out in our debut album review his new album!


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Awesome: The Beatles LOVE
- The album's première was on the Virgin Radio show, The Geoff Show. The presenter, Geoff Lloyd, played the entire 90-minute album — without any breaks. And this was on a commercial station.
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by Alice Ollstein Jun 22, 2015
Many of the presidential candidates are scrambling to return the money received from the white nationalist group leader.
by Kira Lerner Jun 21, 2015
It wouldn't be pretty.
by Zack Ford Jun 18, 2015
The National Organization for Marriage has a litmus test for Republican presidential candidates to oppose marriage equality.
by Judd Legum Jun 3, 2015
A new low.
by Emily Atkin May 31, 2015
Scientists don't think talking about climate change after a weather tragedy is political. In fact, they say, it's necessary.
by Kay Steiger May 20, 2015
Ironically, Cruz suggests focusing same-sex marriage isn't important.
by Carimah Townes May 20, 2015
The sound of silence.
by Judd Legum May 14, 2015
On Monday, Fox News' Megyn Kelly asked Jeb Bush a simple question. Then the trouble started.
by Ian Millhiser May 11, 2015
By the end of the interview, when Halperin asks Cruz to say a few words "en Español," one can't help but think that Cruz had unwittingly wandered into a minstrel show, with Halperin demanding that Cruz perform for an audience.
by Kira Lerner May 4, 2015
"I understand a lot of the concerns raised by a lot of citizens about Jade Helm," he said. "It's a question I'm getting a lot."


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You've Been Arrested for DWI in Charlotte – What To Do Right Now?
Defending a DWI Case is Complex Process. Your Journey Begins When You Hire a DUI Attorney.
First Our Credentials
North Carolina DWI lawyer Robert J. Reeves is a practicing trial attorney here in Charlotte with 25 years experience in both criminal and civil courts. He is licensed in both North Carolina (licensed in 1996) and South Carolina (licensed in 1989). Located across the street from the Mecklenburg County Courthouse, Mr. Reeves focuses his criminal practice on Driving While Impaired (DWI) and Boating While Impaired (BWI) cases. He has undergone the same training as police and received certificates from the National Highway Transportation Safety Administration (NHTSA) in both DWI Detection and Standardized Field Sobriety Testing as well as the Advanced Roadside Impaired Driving Enforcement (ARIDE). Mr. Reeves is an accomplished trial attorney who has been inducted into the National Trial Lawyers Top 100 and is also a member of the National College for DUI Defense. Mr. Reeves will work tirelessly on your behalf and makes himself personally available to his clients to answer questions when you need him – evenings, weekends, and holidays. Mr. Reeves' direct mobile phone number is 704-351-7979 and his direct email address which is email@example.com. We know how stressful this ordeal is to you and will do everything we can to ease your burden. We are going to be engaged in every step of the process, and Mr. Reeves will be there to guide you from start to finish.
The Arrest and DWI Investigation Process
If you're reading this material, you or someone you care about has had a long night. On the way home from dinner or an evening out, you were stopped by police or came upon a DWI checkpoint. You may have had a few drinks but felt fine to drive. Of course, you would never have driven if you thought for a moment you were unsafe. You are a responsible person who does not take chances. Nevertheless, life circumstances can change pretty quickly, and you now find yourself facing a DWI arrest. You still cannot believe this is actually happening. There are many emotions and fears coming into play. Your mind may be racing. Try not to worry. Defending a DWI is a process and it will take time to work through the various stages. That's where our firm can help. We can answer your initial questions and explain what to expect.
You haven't slept very much, because of the stress of going to jail. You think about your driving record and what may even happen with your job. You worry about everything. Is a DWI a felony or a misdemeanor? Will a conviction result in a permanent criminal record? What is this going to cost? What are the court costs and fines? What is this arrest going to do to my automobile insurance rates? How much does an experienced DWI lawyer charge? These are all good questions, and we can help get you answers to all of them. And more.
Regardless of the reason you were initially stopped by police, everything changes once the officer detects any alcohol on your breath. At that point, the focus shifts to a DWI investigation and a DWI arrest. First, you will be asked a series of questions while gathering requested documents such as your driver's license, vehicle registration, and insurance cards. These are "divided attention" tasks. Next, you will be asked to step out of your car and perform "Field Sobriety Tests" on the side of the road. The Standardized Field Sobriety Tests (SFSTs) include the Horizontal Gaze Nystagmus (HGN), Walk and Turn (WAT), and One Leg Stand (OLS).
These sanctioned tests, even if properly administered, are difficult to successfully perform under the best of conditions and without the anxiety of being investigated by police. Even though you may feel like you did well, almost everyone "fails" and gets arrested. You have something of a choice on whether to attempt to comply, but the outcome is usually the same regardless of your good intentions. If you submit to testing, you will most probably fail and be arrested. If you decline testing, you absolutely will be arrested. You get the idea here. Either way, once the investigation starts, you can plan on going to jail.
What To Do When Released
The morning after you get out, the first thing you need to do is to consult with an experienced Charlotte DWI attorney. There are a lot of lawyers who aggressively market for DWI cases. Over the next few days, you're going to receive a significant amount of unsolicited mail from lawyers trying to convince you to hire them. Friends and co-workers will typically want to help and will make suggestions. Almost everyone seems to "know a good lawyer" and how a DWI arrest is supposed to go. We respectfully suggest you do your own research before deciding.
The lawyer you ultimately retain can make a real difference in the outcome of your case. Check out their experience and credentials. You may even want to meet and interview several attorneys. Then, after you have completed a thorough review, you are in a position to make your best choice of who will handle your case. Go with the lawyer who gives you the most confidence and makes you the most comfortable.
Limited Driving Privilege (LDP)
The first thing almost every client wants to know is "when can I drive again?" After a DWI arrest, they are told before being released that their driving privileges are suspended for the next thirty (30) days. During the first ten (10) days, you cannot legally drive at all. In some cases, it is possible to have the license returned even sooner than 10 days. Give us a call to discuss attempting to get your license back sooner. In other cases, we can help you request driving privileges after the 10th day. We will assist you during that period in gathering all necessary information and then prepare documents for a Limited Driving Privilege. On the eleventh (11th) day after your arrest, we will appear in front of a District Court judge and request that they sign and approve your privilege. We then file it with the court, pay your $100 fee, and get you back on the road. After thirty (30) days from your arrest date, you are able to get your original license returned after payment of another $100 fee to the State. We explain this procedure in detail in other sections of this website. Of course, you can call us, and we will further explain what needs to be done.
What is the DWI Court Process
Your first court date and time is shown on the arrest documents given to you when released. All Charlotte DWI cases start in Courtroom 1130 at the Mecklenburg County Courthouse. If you hire our firm, you will sign a Waiver of Appearance form so that we can appear on your behalf. You will not have to be there. On that first date, we will examine all documents in your file and request a second court date in 1130. As before, you will not have to be at that next court date. In the meantime, we will file several standard Motions and request any video evidence that may be available in your case. After the second court date in 1130, your case will start being scheduled on the fourth floor, or the District Court level.
At those scheduled dates, you will have to be present. Our office will send you letters after each court appearance with the new date, time, and courtroom number. There will be several more court dates while we continue to collect all of the State's evidence, including video. We will also personally speak with the arresting officer to learn what was recorded about the circumstances of your arrest. Once we have all the evidence and have carefully reviewed it, we will then be in a position to go over your options so that you can decide what is best for you. We will answer all of your questions, review the pros and cons of your case, and make recommendations. Then, you will decide how you want to proceed. We never pressure our clients on any course of action. Rather, we advise and suggest options. It is always your case and your decision. We always remember that we work for you.
Is a DWI Case Worth Fighting?
Absolutely. A DWI arrest is a misdemeanor, not a felony. But, if you are convicted or plead guilty, a DWI results in a permanent criminal record that can never be expunged even years later. As with all criminal charges, a DWI should be thoroughly investigated and aggressively defended. The burden of proof is on the State of North Carolina, and the prosecution must prove all elements "beyond a reasonable doubt." North Carolina has some of the toughest DWI laws in the country, subject to few legal, rather than factual, defenses. You are beginning a very stressful time in your life. That's why hiring an experienced DWI attorney is critical. We know and understand what is involved and how this process works. We can explain what to expect and answer the questions that are waking you up at night. Then, we can collect all of the State's evidence and then sit down and review a strategy for your case. If you decide to fight the charges, we will get ready for trial. If you decide to plea, we will prepare available mitigators with the goal of minimizing your ultimate punishment level and sentence. The choice of how to proceed is always yours.
The burden of proof is on State of North Carolina. You have to prove nothing.
Being charged is NOT the same as being found guilty. Because a DWI is a criminal matter, you are innocent until proven guilty. The State must prove each element of the DWI charge and must present evidence that convicts "beyond a reasonable doubt." That is a significant standard for the police to meet in order to prove their case against you. If you hire us, we will conduct a thorough "top to bottom" review of your case and all of the State's evidence.
We begin with "reasonable suspicion" and the DWI investigation protocol under NHTSA guidelines. We then proceed to determine if there was sufficient "probable cause" to arrest and if the police followed all mandates with regards to implied consent rights and administration of breath or blood testing. After we have completed our review, we will discuss your options and give you our recommendations. Then, after we answer your questions and address your concerns, you decide how you want to go forward with your case. Plea or trial is always your decision after our counsel.
Thank you for visiting our firm's website. Instead of the usual endless sales pitches on most DWI websites, we have put a lot of real information about what you are facing and what you can expect. We hope the content here helps answer some of your most pressing initial questions. After you have had an opportunity to read this material, the next step is to call us for a thorough, comprehensive review your particular case. Every case is unique, and individual facts can make a real difference in outcome. We will give you a candid assessment and explain your "worst case scenario."
What to Do Right Now? Call our firm for initial answers and guidance.
Unlike some firms, we do not charge a consultation fee. After all, we are the ones interviewing to become your lawyer. However, the legal advice and guidance we provide will help you sleep better tonight even if you don't retain our services. We tell every potential client that their choice on who to represent them should be made carefully after a thorough review of available DWI lawyers here in Charlotte. Of course, we want to be considered and will do our best for you if you place your trust in our firm. Call us now at (704) 334-7897 or contact us online and let's get started.


text:
Top Definition
This occurs when you take a small ball i.e. tennis ball, baseball, etc. and then you knut all over it, effectively creating a sticky plasma grenade. then you throw it at a bitch
The bitch wasn't putting out so i decided to master chief that ho with my tennis ball
by McLovin1174 January 14, 2008


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Skip Beat 34
June 28, 2015
Yoshiki Nakamura – Viz – 2015 – 34+ volumes
I got this in the mail yesterday (4/7, because I'm posting this, like, 3 months later) and read it immediately.
I'm pretty sure everyone in the surrounding three midwestern states heard me shriek during one of the key scenes. That's Skip Beat's power. It makes even old ladies like me squeal with joy.
Seriously, this volume is something else. There's an excruciating scene at the beginning where both the reader and Kyoko think that Lory will drop the hammer down on her. Which, admittedly, isn't really Lory's style, but it's hard to predict him. It turns absolutely wretched and heartbreaking just as everything clears up, and then gets a little creepy as Lory tells Kyoko to "use everything for acting." Ugh.
Later, there's Corn. We haven't really seen him yet. This scene is amazing, and makes you realize that he may be more like Kyoko than it seems.
I'm not saying much about this scene so as not to spoil it, but I was actually laughing and yelling out loud while I was reading this. I don't do that. It's pretty much the best thing the series has offered us so far, and there are a lot of good things in this series.
Anyway. This is a perfect opportunity for the two of them to come clean with one another. If this doesn't lead to heartfelt confession and romance, I'm going to lose faith in shoujo manga.
I see that there are two (!!!) volumes out in Japan. I'll wait patiently.
Skip Beat 33
May 16, 2015
Yoshiki Nakamura – Viz – 2014 – 34+ volumes
Here's a TMI story, because I've been reading and writing about Skip Beat today, and I figured a change of pace for myself is in order.
So, when I was a freshman in college, my fun activity every week was walking down to Borders and buying myself a volume of manga (I had never lived close to a bookstore before, let alone one that sold manga). $10 was a ridiculous luxury to spend on something like that every week, and I felt guilty. So I decided to start reviewing it, in order to extend the value of the $10. I quickly found out that reviewing the volumes worked a lot better if I didn't read more than one volume of a series at a time (the details blur together that way), and I felt like I wasted the money unless I did review every single volume.
Flash forward about 15 years (shut up), and I find myself with a ridiculous compulsion. I cannot bring myself to read the next volume of a series until I've reviewed the last one. I tried to do this, because my to-read pile is terrifying and I wasn't updating my site last year. I figured I could at least enjoy the books I had. But I can't. I have to write about each one in between.
I will usually mention it if I do read consecutive volumes, because it is a ridiculous luxury, and I have to really be enjoying a series in order to convince myself to do it. It happens occasionally with BL, because the series are so short. It feels a bit naughty to binge, but I like re-reading the short series later when I write them up. Even so, there have been very few.
Series that aren't BL that I read consecutive volumes of? In the last 15 years… Blue Exorcist, maybe Basara or Please Save My Earth. And Skip Beat. I can remember the day I caught myself up on the series. I bought the first two, loved them, then bought the next seven and sat in front of the heater and read them in a day. I've re-read this series three or four times over the years, which I can also say absolutely never happens, especially when a series is this long. I can remember where I was when I read many of the volumes in the series the first time. I love it so much, and it means a lot to me.
I say this because I had a three-volume marathon today. I haven't marathoned this series in a long time, but what's going to happen is that I'm going to re-read all thirty-three volumes on Saturday, because this shit is ridiculous.
Kyoko and Ren… are having a conversation at the end of the last volume. Kyoko rightly assesses the fact Ren is being a little bitch about this conversation, and then starts dominating it. She is in character as Setsu, Ren… is not in character. I think Kyoko isn't really sure who's she's talking to (it's Kuon, but she doesn't know him. She only knows it's not Ren Tsuruga or Cain Heel), but she rolls with it as Setsu. Things get… steamy.
Skip Beat – the manga where one of the main characters is always making a face as if the other is going to kill them.
Then, Kyoko breaks character as Setsu to state her opinion to Ren. Her face, and her words, are downright cold-blooded. I loved it.
Things never stop being weird. I think Ren has… kind of gotten comfortable with Kyoko, and starts abusing the Heel Siblings' relationship to get close to her. He also starts picking up on her anxiety, and trying hard to help her feel better. Does he know she's close to falling in love?
One fantastic technique in this volume is that Kyoko is obviously forced to act as Setsu. But she is warring with her emotions, and whenever Kyoko Mogami's personality and wants make themselves known, there is a panel of her plain face in between the ones where she's wearing Setsu's makeup to indicate she's not acting.
There is a great scene at the end of the volume where Kyoko imagines what Ren would say if he knew she was falling in love with him. There's a great panel where he's telling her "I feel so betrayed… You have no willpower… and you're slutty, too. You're not Kyoko anymore, I'll call you Ho-ko instead."
I feel like I want to cross-stitch it, put it on my wall, attribute it to Ren, and call it the greatest line in shoujo manga history.
Ho-ko. Because she fell in love with him.
Anyway. At the end of the volume, we are finally making progress in Ren and Kyoko's relationship. Maybe. Unless Kyoko takes it all back next time.
But the scene at the beginning of the volume was worth reading the entire series over and over again.
Skip Beat 32
April 12, 2015
Yoshiki Nakamura – Viz – 2013 – 34+ volumes
Oh man, the Sho volume didn't disappoint. I think Sho is a terrible human being, but I can't help but love his effect on Kyoko and Ren. He gets both of them stirred up so much. The way he was teasing Kyoko at the beginning of the volume was priceless. I especially loved the fact he bought the last of the rice balls he knew she would like, and then taunted her with one.
But really, the clear winner in that scene was the look on Kyoko's face when she saw Ren. There is nothing quite like the look of terror that Yoshiki Nakamura can conjure on her good days.
Sho in general is very funny. That his manager can peg his bizarre behavior so accurately is still quite amusing (his terrifying deity faces when he talks to Kyoko, the fact she guessed correctly where he went to see Kyoko, how he knew she was there, and exactly what his reward was for the service, et cetera).
Meanwhile, Ren is sort of the winner/loser here. He has a great scene with Kojima at the beginning of the volume, where he seems to (cheerily?) imply he's interested in Kyoko. Apparently Kojima doesn't know this, and isn't actually trolling him? The look on his face was cute, at any rate.
Later, he's so pissed off that he can't even keep up his professional "Ren Tsuruga" personality, and people start to notice. While this is kind of cool, it's also annoying, since there's no reason for him to be rocked so hardcore professionally by jealousy over Sho. Jealousy he doesn't even ask Kyoko about directly.
"Kuon" does make himself known more and more, which is the point of the Heel Siblings storyline. I do like that Ren has a persona he hides away from people, one who is kind of a blunt asshole, the same way Kyoko has a persona she keeps from most of her professional contacts (the blunt asshole part is, of course, the Shotaro persona, but there's also the crazy girly side that nobody knows about). They kind of match, although I'm having a hard time warming up to Ren's harsher side. Then again, we haven't seen very much of him yet.
The end of this volume though!!! While I am angry that so much pressure was put on Kyoko over a phone call she didn't even answer, the result.
Skip Beat 31
March 18, 2015
Yoshiki Nakamura – Viz – 2013 – 34+ volumes
As per usual, it's hard for me to be fair and reasonable about this series, as my passion burns with the energy of a thousands suns. My fair and reasonable opinion is that this is great, very funny shoujo, and any shoujo fans should probably give it a try. Even 31 volumes in, there are still awesome character quirks thrown in for no reason. One of my favorites here is the energy that Yashiro puts into creepily eavesdropping on the conversation between Ren and Kijima. Pick it up, and start from the beginning. Do yourself a favor.
Now I'm just going to fangirl for awhile.
THIS VOLUME WAS SO BORING. I've been waiting three years for the good stuff! This is Ren acting out in his role as Cain again, and everyone freaking out, and then everyone holding their heads, because they don't know what's wrong with Ren and/or whether he will win his internal battle. WE'VE BEEN READING THIS FOR SEVERAL VOLUMES NOW. I'm tired of the Cain/Setsu plot! I want the story to move on to something else, like maybe Kyoko or Ren actually opening up to one another. It's been thirty-one freaking volumes.
There were two bright spots, though. One was the e-mail conversation between Kijima (who is obviously trolling Ren at the end of the volume) and Kyoko. Everything about this was great. Especially Kijima preying on Kyoko's love for cute things, and Kyoko's war with herself about how cute she could be in an e-mail to a senior actor.
The other bright spot was NEXT VOLUME (hopefully) IS A SHO VOLUME. I live for these.
I am sorry
not sorry for the emphasis. This volume was recently excavated from the depths of my to-read pile, and I have the luxury of three volumes of this series to read. My heart will burst with joy.
Skip Beat 30
February 9, 2013
Yoshiki Nakamura – Viz – 2013 – 30+ volumes
This series. I've been reading only a handful of manga volumes lately, but this series is one of them. It's my favorite, and for good reason. Every single volume of this makes me laugh. The characters just never stop going through hilarious trials.
This time around, honestly, there's not a whole lot going on. Kyoko and Ren are still playing the brother/sister pair of Cain and Setsu Heel. Ren's past comes back to haunt him, and we get glimpses of a hoodlum lifestyle as he lets himself get carried away during a "staged" fight with a castmember he isn't getting along with. Kyoko wonders if and how Ren was in character during the fight, though the thought that he was "someone else" instead of Cain or BJ (the character in the movie) terrifies her. It terrifies Ren, too, and he starts getting a little… close to Kyoko. In a way she isn't comfortable with. And that's pretty hilarious. Kyoko winds up having to call someone to get advice about Ren. We get to see Yashiro in the buff, for some reason. Well, the reason is that this series is awesome, and just throws in things like that sometimes. And that's good enough for me.
Actually, this volume is a little less funny than other volumes in the series, but it's still pretty enjoyable. I do complain that the story and relationship isn't advancing fast enough in this series, but when it does, here I am complaining it's just not funny. We get healthy doses of Ren's past (which has been doled out sparingly thus far) and a closeness between Ren and Kyoko, which is also something that hasn't really been happening much. I do like that, but the latter still isn't quite what one has in mind for the typical shoujo couple. Still, it's Skip Beat, and this series does its own thing.
The rundown this time is pretty thorough, and I don't have too much else to add that I haven't already said about this series. It's awesome, and one of the best and freshest shoujo series I'm reading right now. Even 30 volumes in, I'm still dying to read every volume as soon as it arrives at my house. I'm never disappointed. And, happily, it's being reprinted in the new 3-in-1 edition from the beginning. You'll need three volumes at a stretch when you start this series, too. It's good stuff.
This was a review copy provided by Viz.
Skip Beat 29
October 26, 2012
Yoshiki Nakamura – Viz – 2012 – 31+ volumes
Skip Beat is my favorite right now. Period. Every volume brings me great joy. I will gush for approximately 500 more words about this volume. You should be prepared for that.
A big chunk of the beginning of the volume concerns the wrap party for Dark Moon. Also, whether or not Kyoko has fallen for Ren. You know. Nothing big. She also agrees to date the Dark Moon co-star, who is portrayed as sort of a ladies' man. And Ren may or may not make her promise to consult with him on all things having to do with men from now on. And Kyoko may have a hard time figuring out whether he's acting, or is actually interested in her, or is just like that with everyone.
My heart! And yet! Still not a couple! Shame on you two!
The end of the volume goes back to Cain and Setsuka Heel, this time on the set of Cain's movie. To be fair, Setsuka's excuse to be on set is pretty flimsy and shoujo-tastic, but the setup is so good I just don't care, it's great to see the two of them acting together. Ren makes a fantastic BJ evil-type character, and it's a lot of fun seeing him channel the tough guy persona (which is hinted to be his real personality, I guess) to keep Kyoko safe from the prying eyes of costars. And I love love LOVE seeing Kyoko's reaction to all of this. She's just so much fun, and all of it is good for a laugh.
I guess that's probably enough gushing for now (far short of my 500 words). I still don't really have anything substantial to say, other than this series is my absolute favorite shoujo manga running right now for very good reasons, romance and funny being at the very top. Seriously. Take advantage of the new 3-in-1s, or go back through the internet and read all the gushing that every single person that reads it does (to be fair, some people are turned off by the page layouts, which can stretch out forever sometimes). It's great, and I'll stand by that.
This was a review copy provided by Viz.
Skip Beat 28
June 21, 2012
Yoshiki Nakamura – Viz – 2012 – 30+ volumes
Again, this series doesn't even make it out of the box before I've read it cover-to-cover. This is my absolute favorite shoujo series running in English at the moment. Aside from some wonky art composition, there's very little to dislike about this series, and if you haven't had the chance to check it out yet, I highly recommend the new 3-in-1 volumes that are being reissued. 3 volumes still isn't a big enough chunk of Skip Beat to satisfy, and you'll want all 28 once you start. Then again, you may be disappointed when you get this far and realize that the main couple still isn't together, but that is the blessing and the curse of Skip Beat. It's still good, despite all that.
This is a more serious volume, with an accident for Ren at the beginning triggering more serious thoughts for both Ren and Kyoko. Ren has to deal with and conquer his past, which is still up in the air as of the end of the volume. And Kyoko has to ask herself what's the matter with Ren, that he's taking all of this so hard. Plus… she admits to herself that the locks are falling off the box. I'm sure this isn't going anywhere in a hurry, it being Skip Beat and all, but I'm looking forward to the next volume like nobody's business all the same.
This one is slow, and there's a lot about Ren's past here. Incredibly, it goes on for a whole volume without telling us a whole lot about the people in Ren's life, or how he got to be a delinquent. Annoying.
But there are a lot of sweet scenes between Ren and Kyoko. It's Kyoko that helps Ren after the accident, and Kyoko that helps him through the tough mental blocks. Again, it's not nearly as funny as some of the best parts of the series, but this is a relatively serious bit of story, so it's appropriate the humor has been toned down. There's still some choice moments, though. Ren still teases Kyoko quite a bit, and there's a great scene in a supermarket where (I think) he feigns ignorance at the quality of chicken and decides a super-expensive brand is better based on price. There's stuff like that slipped in there, and even some cute stuff in Ren's flashbacks (I was fond of the rooster named Brian), but mostly it's very serious and sad.
But it's still Skip Beat, and I still loved every page. The last few pages are cruel, and make me want the next volume badly. But I would have wanted it anyway. I know they still aren't going to get together, but I want to be lead on, and mostly, I want to laugh at Kyoko and Ren's mutual humiliation at the hands of Yoshiki Nakamura. That is the beauty of Skip Beat.
This was a review copy provided by Viz.


text:
©2002 Global 13 Publications; (P)2002 Global 13 Publications
"Wow! It worked for me"
Cynthia must have written her response immediately rather than waiting to see what happened. I went through the 13 Steps to Radical Forgiveness and I too thought nothing happened, but later on I realized I had released all my pent up anger and was feeling peaceful again. Wow! It worked for me. Try it again Cynthia.
"I hate paying for advertising!"
Don't waste your money! This is nothing but an ad for the author's web site and products.
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'Miracle survivor' Cumbrian solicitor becomes charity ambassador
Last updated at 12:29, Tuesday, 26 February 2013
A solicitor who fought a rare brain tumour which killed almost everyone else who contracted it has been named an ambassador for a national charity.
Tim Frost's tumour was so rare there have only been about 50 reported cases in the world, and it took doctors almost three weeks to diagnose it.
Despite a prognosis that was so poor the 52-year-old began planning his funeral, he beat the odds and has vowed to put his experience to good use.
Mr Frost, who lives in Wigton but has offices in Carlisle, Workington and Whitehaven, said he was first aware there was something wrong while on holiday.
"I'd had some really bad headaches while in Croatia," he said. "I thought it was too much sun. I put a cold pack on for a few days and it eased.
"I came back from holiday and after a few days the headaches started again. Eventually, after the tenacity of my GP, I went to hospital for a CT scan and they found the tumour."
The tumour was on his right frontal lobe, pushing against his brain and causing the headaches.
Mr Frost underwent an operation, and was told the tumour was malignant and very fast-growing.
He continued: "I was in complete and utter shock – I just thought it was a bit of stress or something. It was certainly a real eye-opener."
After three weeks of tests, doctors finally diagnosed the tumour as granular cell astrocytoma, an extremely rare type.
Mr Frost said he immediately looked on the internet for information about this tumour, and the results were horrifying.
"I found there were 49 previous cases, all in America – and they all died,"he said.
"I began doing all those things you have to do before you die: I created a living will, so my partner did not have to worry about that if he didn't want to.
"I was also planning our civil partnership at the same time as planning my funeral."
Mr Frost continued: "Whatever happened, there was going to be a celebration in the future: I just didn't know if it would be a celebration of my life, or me and my partner celebrating our day together."
After intensive chemotherapy and radiotherapy, Mr Frost went into remission and is proud to say his most recent scans are still clear.
"I've beaten the odds in one respect," he admitted. "In the words of my oncologist, I'm a bit of a miracle."
Mr Frost has now agreed to step up and be an ambassador for the Brain Tumour Charity in Cumbria, helping with fundraising but also with raising awareness.
The charity is relaunching next month following a merger of The Brain Tumour Charity and Brain Tumour UK, to celebrate Brain Tumour Awareness Month.
He has bigger plans than even that of the charity though, as Mr Frost is hoping to set up a helpline in the future, offering advice to people who have been recently diagnosed or are struggling.
The solicitor is currently helping to promote Street Spice, a world spice festival taking place in Newcastle from Thursday to Sunday, which will raise money for the charity. For information visit streetspice.co.uk
The Brain Tumour Charity is asking people to buy a bandana to wear on Friday, March 1, from www.thebraintumourcharity.org/bandanas. Alternatively, people can wear their own and make a donation to the charity.
First published at 12:08, Tuesday, 26 February 2013
Published by http://www.newsandstar.co.uk
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Is this restaurant family-friendly?
Is this restaurant good for lunch?
Does this restaurant offer takeout or food to go?
Does this place serve noodles?
Is this restaurant good for dinner?
Does this restaurant serve Asian food?
Does this restaurant serve Vietnamese food?
Is this restaurant good for breakfast?
Is this restaurant good for brunch?
Does this restaurant offer free wifi?
Thanks for helping!
Service is average, food is average and prices are average. There is nothing bad or great about the place.
I go there for lunch sometimes. I get the fresh shrimp spring roll and a small seafood pho. The spring roll is great, the peanut sauce they give with it has the smallest taste of spicy but not much and costs $5 for 4. The seafood pho is pretty big, for a small. I don't think I could eat the...
This place is getting really bad. Horrible service, the Pho is very inconsistent and most of the time the broth is very greasy. The meat portions are very small comparing to other Bay Area Pho restaurants. To make things worst, most of the time the meat is so fat that you can't even eat. Now the best part??? When you...
Pho Dong is not an elegant restaurant, but the food is wonderful and the prices reasonable. As a vegetarian, my favorite dish is their "Tofu Crispy Egg Noodle." It is incredible, better than any I've had elsewhere. My wife usually gets a Pho dish with a variety of meats and seafood--they are more than willing to accommodate special requests. She...
Pho Dong is a welcoming place where dishes are tasty and colorful. Anything with seafood is really super delicious!
There with a group of seven adults. Service was fast, attentive and friendly. We shared a variety of appetizers, pho, and stir fried dishes. Everything was very good. I particularly enjoyed the Vietnamese Crepe appetizer, basil egg plant, and salt and pepper calamari.
I love a good Pho and Pho Dong is the best one I've tasted in Redwood City so far. I've tasted better ones in Asia but what Pho Dong is pretty good. I love to eat their Pho without meat and just ask for extra fresh bean sprouts - this makes for a delicious healthy meal. I tried their salt...
The three of us were looking for something different for lunch as we were heading into San Francisco and this was a good choice. Stopped in around 12:00 on a Saturday and there were not many people there. We were greeted immediately and the service was quick. Our soup and noodles were bought out rather quickly. Everything was hot and...
This place used to be one of my faves in Redwood City, but a while ago it changed hands. The restaurant name and menu remained, but the service level fell off a cliff. Maybe they've worked out the kinks, I'll be watching Trip Advisor for other reviews before going back.
It's called Pho Dong... and they have Pho, Dang!
Lots of difference options!
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Publications (82)388.58 Total impact
Article: Adenocarcinoma of the gastrointestinal tract in lung transplanted patients with cystic fibrosis: case series and review of the literature[Show abstract] [Hide abstract]
ABSTRACT: Cystic fibrosis (CF) is one of the most common genetic disorders. Mutations of the cystic fibrosis transmembrane regulator causes dysfunction of epithelial membranes within the gastrointestinal and respiratory system. Patients with CF are known to be at risk for gastrointestinal malignancies, and lung transplantation further increases this risk. We report a case series of three CF patients who developed adenocarcinoma of the gastrointestinal tract in the posttransplant setting. One of these case histories describes a gastric cancer, which is a novel and to date unreported observation. These data emphasise the importance of checking CF patients for the development of abdominal complications following lung transplantation.Schweizerische medizinische Wochenschrift 08/2015; 145:w14165. DOI:10.4414/smw.2015.14165 · 2.09 Impact Factor
Article: Lung auscultation - An overview[Show abstract] [Hide abstract]
ABSTRACT: The auscultation of the lungs is - among anamnesis - the most important part in the assessment of patients presenting with pulmonary symptoms. The lung auscultation is reproducible, cost efficient and very helpful to distinguish between differential diagnoses, in particular in emergency situations. Detection and description of lung sounds requires experience and should be performed by strict adherence to the internationally accepted terminology. © Georg Thieme Verlag KG Stuttgart · New York.DMW - Deutsche Medizinische Wochenschrift 07/2015; 140(14):1078-1082. DOI:10.1055/s-0041-102883 · 0.54 Impact Factor
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ABSTRACT: Antiproliferative strategies have emerged as a potential therapeutic option for pulmonary arterial hypertension (PAH). To evaluate the long-term efficacy and safety of imatinib. This is an observational study of 15 patients with idiopathic PAH (n = 13) or PAH associated with connective tissue disease (n = 2) treated off-label with imatinib 400 mg daily. Pulmonary hypertension-specific therapy was established in all patients (triple therapy in 10, dual therapy in 3, and monotherapy in 2 patients). After 6 months, improvement in hemodynamics (p < 0.01), functional class (p = 0.035), and quality of life (p = 0.005) was observed. After a median follow-up of 37 months, there was a sustained improvement in functional class (p = 0.032), quality of life (p = 0.019), and echocardiographic parameters of right ventricular function (p < 0.05). Three patients (20%) presented with completely normal echocardiography, absent tricuspid regurgitation, and normal pro-brain natriuretic peptide levels, indicative of 'hemodynamic remission'. Of note, however, only 1 case was assessed by invasive hemodynamics. The overall 1- and 3-year survival was 100 and 90%, respectively. Two patients experienced a subdural hematoma (SDH), which in both cases resolved without sequelae. After careful consultation of the potential risks and benefits, all patients as well as a safety cohort of 9 subsequent cases decided to continue the imatinib therapy. After adjusting the target international normalized ratio (INR) to around 2.0, no further cases of SDH occurred during 50 patient-years. Long-term treatment with imatinib may improve the functional class and quality of life. Single cases might even attain hemodynamic remission. The occurrence of 5% SDH per patient-years is concerning. However, adjusting the INR to around 2.0 might obviate this complication. © 2015 S. Karger AG, Basel.Respiration 06/2015; 89(6). DOI:10.1159/000381923 · 2.59 Impact Factor
Article: The prognostic impact of exercise right heart catheterization in patients with precapillary pulmonary hypertension on transplant-free survivalPneumologie 05/2015; 69(05). DOI:10.1055/s-0035-1551925
Article: microRNA-125a in pulmonary hypertension: Regulator of a proliferative phenotype of endothelial cells[Show abstract] [Hide abstract]
ABSTRACT: Vascular remodeling due to excessive proliferation of endothelial and smooth muscle cells is a hallmark feature of pulmonary hypertension. microRNAs (miRNAs) are a class of small, non-coding RNA fragments that have recently been associated with remodeling of pulmonary arteries, in particular by silencing the bone morphogenetic protein receptor type II (BMPR2). Here we identified a novel pathway involving the concerted action of miR-125a, BMPR2 and cyclin-dependent kinase inhibitors (CDKN) that controls a proliferative phenotype of endothelial cells. An in silico approach predicted miR-125a to target BMPR2. Functional inhibition of miR-125a resulted in increased proliferation of these cells, an effect that was found accompanied by upregulation of BMPR2 and reduced expression of the tumor suppressors CDKN1A (p21) and CDKN2A (p16). These data were confirmed in experimental pulmonary hypertension in vivo. Levels of miR-125a were elevated in lung tissue of hypoxic animals that develop pulmonary hypertension. In contrast, circulating levels of miR-125a were found to be lower in mice with pulmonary hypertension as compared to control mice. Similar findings were observed in a small cohort of patients with precapillary pulmonary hypertension. These translational data emphasize the pathogenetic role of miR-125a in pulmonary vascular remodeling. © 2015 by the Society for Experimental Biology and Medicine.Experimental Biology and Medicine 04/2015; DOI:10.1177/1535370215579018 · 2.17 Impact Factor
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ABSTRACT: Levels of microRNAs (miRNAs) are increasingly assessed in biological fluids, for example, in samples obtained by bronchoalveolar lavage (BAL). "Post-collection kinetics" of miRNA expression levels, however, have not been investigated to date. In these experiments, we analyzed the dynamic expression profile of 5 different miRNAs (miR-17, miR-19b, miR-20b, miR-125a, and miR-223-3p) in BAL within the first 24 h following collection by routine bronchoscopy. miRNAs were quantified 0, 1, 4, 8, and 24 h after collection in samples that were kept at 4 °C or at room temperature. The expression of all five miRNAs was found to remain stable between the first 8 h after collection. 24 h after collection miRNAs faced substantial alterations in their expression profile. These data emphasize that BAL samples intended for further miRNA analysis can be handled at room temperature within the first 8 h after bronchoscopy.Beiträge zur Klinik der Tuberkulose 03/2015; 193(3). DOI:10.1007/s00408-015-9719-5 · 2.27 Impact Factor
Article: Evidence for an Association Between Tako-Tsubo Cardiomyopathy and Bronchial Asthma: Retrospective Analysis in a Primary Care Hospital[Show abstract] [Hide abstract]
ABSTRACT: We investigated the prevalence of bronchial asthma in patients with Tako-Tsubo Syndrome (TTS). This retrospective case-series study was conducted in a primary care hospital in Zurich, Switzerland. Data of all patients with newly diagnosed TTS (2002 - 2012) were assessed electronically by the use of ICD-10. Asthma prevalence was compared to published epidemiologic data. Bronchial asthma is characterized by airway inflammation and, during attack, release of endogenous catecholamines. Sympathomimetic drugs are the mainstay of treatment for asthma patients. Likewise, catecholamine mediated diffuse microvascular myocardial dysfunction seems to be of critical importance for the development of TTS. 20 cases of TTS were identified. 90% were female, showed a median age of 70±13y [25y - 90y], an apical and/or midventricular ballooning pattern with preserved basal function and a median initial LVEF of 34±9% [25% - 55%]. 65% of patients underwent coronary angiography to rule out significant coronary artery disease. Hypertension was present in 45% of patients, 35% were smokers, none was suffering from diabetes. Prevalence of asthma in patients with TTS was significantly higher compared to the normal population (25% vs. 7%, p=0.012). In 30% of the TTS patients an iatrogenic cause for development of TTS was identified. Prevalence of asthma was significantly higher in patients with TTS compared to epidemiologic data from an age-matched population. Phenotypes of patients developing obstructive ventilatory disease and TTS might share common pathogenic mechanisms beyond the use of bronchodilatators. In addition, we identified other iatrogenic etiologies in patients with TTS.The Open Cardiovascular Medicine Journal 02/2015; 9(1):1-4. DOI:10.2174/1874192401509010001
Article: The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A[Show abstract] [Hide abstract]
ABSTRACT: Excessive proliferation of human pulmonary artery smooth muscle cells (HPASMC) is one of the major factors that trigger vascular remodeling in hypoxia-induced pulmonary hypertension. Several studies have implicated that hypoxia inhibits the tumour suppressor p21 (CDKN1A). However, the precise mechanism is unknown. The mouse model of hypoxia-induced PH and in vitro experiments were used to assess the impact of microRNAs (miRNAs) on the expression of CDKN1A. In these experiments, the miRNA family miR-130 was identified to regulate the expression of CDKN1A. Transfection of HPASMC with miR-130 decreased the expression of CDKN1A and, in turn, significantly increased smooth muscle proliferation. Conversely, inhibition of miR-130 by anti-miRs and seed blockers increased the expression of CDKN1A. Reporter gene analysis proved a direct miR-130-CDKN1A target interaction. Exposure of HPASMC to hypoxia was found to induce the expression of miR-130 with concomitant decrease of CDKN1A. These findings were confirmed in the mouse model of hypoxia-induced pulmonary hypertension showing that the use of seed blockers against miR-130 restored the expression of CDKN1A. These data suggest that miRNA family miR-130 plays an important role in the repression of CDKN1A by hypoxia. miR-130 enhances hypoxia-induced smooth muscle proliferation and might be involved in the development of right ventricular hypertrophy and vascular remodeling in pulmonary hypertension. Copyright © 2015. Published by Elsevier Ltd.The International Journal of Biochemistry & Cell Biology 02/2015; 61. DOI:10.1016/j.biocel.2015.02.002 · 4.05 Impact Factor
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ABSTRACT: Background: Registries are important for real-life epidemiology on different pulmonary hypertension (PH) groups. Objective: To provide long-term data of the Swiss PH registry of 1998-2012. Methods: PH patients have been classified into 5 groups and registered upon written informed consent at 5 university and 8 associated hospitals since 1998. New York Heart Association (NYHA) class, 6-min walk distance, hemodynamics and therapy were registered at baseline. Patients were regularly followed, and therapy and events (death, transplantation, endarterectomy or loss to follow-up) registered. The data were stratified according to the time of diagnosis into prevalent before 2000 and incident during 2000-2004, 2005-2008 and 2009-2012. Results: From 996 (53% female) PH patients, 549 had pulmonary arterial hypertension (PAH), 36 PH due to left heart disease, 127 due to lung disease, 249 to chronic thromboembolic PH (CTEPH) and 35 to miscellaneous PH. Age and BMI significantly increased over time, whereas hemodynamic severity decreased. Overall, event-free survival was 84, 72, 64 and 58% for the years 1-4 and similar for time periods since 2000, but better during the more recent periods for PAH and CTEPH. Of all PAH cases, 89% had target medical therapy and 43% combination therapy. Of CTEPH patients, 14 and 2% underwent pulmonary endarterectomy or transplantation, respectively; 87% were treated with PAH target therapy. Conclusion: Since 2000, the incident Swiss PH patients registered were older, hemodynamically better and mostly treated with PAH target therapies. Survival has been better for PAH and CTEPH diagnosed since 2008 compared with earlier diagnosis or other classifications. © 2015 S. Karger AG, Basel.Respiration 02/2015; 89(2). DOI:10.1159/000370125 · 2.59 Impact Factor
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ABSTRACT: Background: An atherosclerotic disease burden sufficient to put lung transplant candidates at risk for end-organ disease after transplantation is considered to be a relative contraindication for lung transplantation. Objectives: The aim of this study was to assess our current practice of cardiac workup by coronary angiography in lung transplant candidates ≥50 years of age. Methods: We retrospectively analyzed 50 consecutive lung transplant candidates ≥50 years of age in which coronary angiography was performed at the University Hospital Zurich (2009-2013). For every patient, the risk of developing an acute coronary event was estimated by using a recalibrated version of the PROCAM study calculator for the Swiss population. Results: The median estimated risk of developing an acute coronary event within 10 years in the study cohort (n = 50) was 4.2% (interquartile range 1.9-7.6), which is considered to be a low risk. Sixteen percent of patients were considered to be at intermediate risk. In 66% of patients, coronary angiography showed no coronary artery disease (CAD). In 28% of patients, CAD without significant stenosis was diagnosed. In 6% of patients, significant coronary stenosis was detected requiring percutaneous coronary intervention. No correlation between the coronary status and the risk score or cardiovascular risk profile was found. Conclusions: The high prevalence of asymptomatic CAD in lung transplant candidates without correlation to a common clinical risk score supports the important role of coronary angiography for the assessment of coronary artery status. This approach might prevent cardiovascular events and improve long-term survival after transplantation. © 2015 S. Karger AG, Basel.Respiration 01/2015; 89(2). DOI:10.1159/000368368 · 2.59 Impact Factor
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ABSTRACT: Lung transplant recipients require life-long profound immunosuppression, making them prone to respiratory tract infections (RTIs), in particular viral infections, during the winter season. Since RTIs may have severe consequences, of which acute or chronic allograft dysfunction is feared most, early diagnosis and treatment are recommended. Patients monitor lung function daily at home and are instructed to contact the transplant center in case of signs and symptoms suspicious of RTIs. We then obtain nasopharyngeal swabs for viral and bacteriological examination and initiate pre-emptive treatment with antivirals, broadband antibiotics, and sometimes intravenous immunoglobulins. Treatment duration is guided by virology sampling results. As preventive measures, we provide vaccination against seasonal influenza for patients and household contacts and recommend specific daily hygiene measures.12/2014; 16(3):144-149. DOI:10.5152/ejp.2014.87597
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ABSTRACT: Pulmonary hypertension is defined as an increase of the mean pulmonary arterial pressure above 25 mm Hg and, as such, the diagnosis requires invasive haemo dynamic measurement by right heart catheterisation. More than just a single disease, pulmonary hyperten sion is an umbrella term that includes many different disorders and pathophysiological entities. However, most forms of pulmonary hypertension share a final common pathway, in particular the trias of vasocon striction, microthrombosis and vascular remodelling. The classification of pulmonary hypertension has been subjected to many changes within the last decade. At the same time, major achievements in our understand ing of the complex pathobiology have been made. Here, these developments are discussed in the light of the re cently published report from the fifth World Sympo sium on pulmonary hypertension.
Article: Long-term Effect of Vasodilator Therapy in Pulmonary Hypertension due to COPD: A Retrospective Analysis[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: Pulmonary hypertension (PH) due to COPD has dismal prognosis. We reviewed the long-term effect of PH-target therapy in severe PH-COPD. METHOD: Patients attending our PH-clinic were reviewed for PH-COPD receiving PH-target therapy. Baseline characteristics, death/transplantation until 2014, therapy, NYHA functional class, 6 min walk distance (6MWD) and oxygen saturation (SpO2) at baseline, 3, 6, 12 and 24 months were analysed. RESULTS: Of 48 PH-COPD identified 21 were excluded (insufficient data, comorbidity). 27 patients (7 females, 21 smokers, 23 emphysema) with median (quartiles) baseline age 70 (60; 76) years, FEV1 60 (46; 78) %, FEV1/FVC 57 (51; 64) %, DLCO 42 (36; 59) %, mean pulmonary artery pressure 39 (32;44) mmHg under inhaled iloprost (10), subcutaneous prostanoids (2), intravenous prostanoids (3), endothelin receptor antagonists (15) and phosphodiesterase-5-inhibitors (25) were included. Under therapy, NYHA functional class improved from 3.5 (3; 4) to 3 (2; 4) after 3 months and 3 (2; 3.5) after 6 months (p = .02 and .008). The 6MWD improved from 373 (236; 452) to 395 (339; 472), 414 (285; 492) and 396 (308; 497)m at 3, 6 and 12 months (p = .005, .006 and .011) with unchanged resting-SpO2 but decreased peak-exercise SpO2. During median follow-up of 5.9 (2.3; 8.4) years, 10 died, 2 were transplanted and 2 were lost to follow-up. Transplant-free survival at 1,2,3 years was 92,69,54 % and was similar for GOLD stages 1-4, but worse for patients with mPAP ≥40 mmHg (p = .026), 6MWD <370 m (p = 0.008), resting SpO2 <92 % (p = 0.02) and peak-walk SpO2 <87 % (p = 0.012). CONCLUSION: PH-target vasodilator therapy improved NYHA functional class and 6MWD up to one year in highly selected patients with severe PH-COPD. Poor exercise capacity, low SpO2 and high mean pulmonary artery pressure at baseline but not airflow obstruction were associated with unfavourable outcome.Beiträge zur Klinik der Tuberkulose 10/2014; 192(6). DOI:10.1007/s00408-014-9650-1 · 2.27 Impact Factor
Conference Paper: The micro-RNA hsa-miR-502-3p is down-regulated in the plasma of obstructive sleep apnea patients after 2 weeks of continuous positive airway pressure therapy withdrawal: Data from a randomized controlled trial.[Show abstract] [Hide abstract]
ABSTRACT: Introduction MicroRNAs (miRs) are involved in the fine tuning of gene expression in cellular processes and can be quantified in plasma. miRs represent a distinct class of easily accessible biomarkers and may play a role in clarifying pathogenic pathways in diseases involving the vascular system, such as obstructive sleep apnea (OSA). Methods miRs were isolated from stored plasma samples of OSA patients who participated in a randomized controlled trial defining the effects of a two-week continuous positive airway pressure (CPAP) therapy withdrawal. The plasma concentrations of 14 miRs selected in a pilot experiment, were measured by qPCR. Results The mean oxygen desaturation index (ODI) change from baseline was 43.0/h (SD 14.5, n=14) in the CPAP withdrawal group and 0.2/h (SD 1.8, n=14) in the CPAP group. Compared to continuing CPAP therapy CPAP withdrawal was associated with a down-regulated plasma concentration of hsa-miR-502-3p by a factor of 2.0 (n=14, p=0.045). In contrast, the plasma concentration of hsa-miR-210, a key regulator in the response to hypoxia, did not change (n=14, p=0.137). Conclusion Short-term CPAP therapy withdrawal in OSA patients resulted in a statistically significant change in the plasma concentration of hsa-miR-502-3p. In vitro studies are necessary to identify possible targets of hsa-miR-502-3p and to substantiate the relevance of our finding in OSA.Annual Congress of the European Respiratory Society (ERS) 2014, Munich, Germany; 09/2014
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ABSTRACT: Bronchiektasen bezeichnen irreversibel erweiterte Atemwege. Genaue epidemiologische Angaben zur Prävalenz von Bronchiektasen existieren nicht, sie sind aber häufig und werden zunehmend als solche erkannt. Eine Vielzahl von Erkrankungen und Auslöser können zu Bronchiektasen führen, häufig bleibt ihre Ätiologie unklar. Eine chronische pulmonale Infektion mit Pseudomonas aeruginosa ist mit einem schwereren klinischen Verlauf assoziiert und beeinflusst das therapeutische Management. Physiotherapie, mukoaktive Substanzen und Antibiotika sind die Eckpfeiler der Therapie von Bronchiektasen. Einen zunehmenden Stellenwert hat die immunmodulatorische Therapie mit Makroliden. In dieser Übersicht werden notwendige Abklärungen und neueste Entwicklungen hinsichtlich therapeutischer Ansätze bei Non-CF-Bronchiektasen diskutiert. Bronchiectasis is the term used for irreversibly dilated airways. Exact epidemiological information on the frequency of bronchiectasis is not available, but the morphological findings are increasingly detected and the associated syndrome is more frequently diagnosed due to improved imaging techniques and increased awareness among chest physicians. The workup of these patients includes a wide panel of investigations guided by patient history and clinical presentation. Despite thorough evaluation the aetiology frequently remains unclear. Chronic infection with Pseudomonas aeruginosa is associated with a severe course of the disease and its detection has impacts on the therapeutic management. Chest physiotherapy, mucoactive substances and antibiotics are the mainstay of therapy. In this review the evaluation of bronchiectasis and the recent therapeutic insights for non-cystic fibrosis bronchiectasis are discussed.DMW - Deutsche Medizinische Wochenschrift 08/2014; 139(34-35):1714-20. DOI:10.1055/s-0034-1370258 · 0.54 Impact Factor
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ABSTRACT: Im Unterschied zur pulmonal-arteriellen Hypertonie, welche eine seltene Erkrankung ist, umfasst der Überbegriff der pulmonalen Hypertonie ein klinisch häufigeres Krankheitsbild. Die pathophysiologische Trias von Vasokonstriktion, Mikrothrombosen und Gefäßumbau (Remodelling) findet sich dabei unabhängig von der zugrundeliegenden Entität in unterschiedlich starker Ausprägung bei praktisch allen Formen der pulmonalen Hypertonie. In dieser Übersichtsarbeit werden neue Aspekte in der Pathogenese des pulmonal-vaskulären Remodellings, insbesondere mikroRNA-abhängige Mechanismen, besprochen. MikroRNAs sind kleine RNA-Fragmente, welche an die messengerRNA eines Zielgenes binden, was zum Abbau des Zielgenes oder zur Translationshemmung des betreffenden Gens führt ("gene silencing"). Im Zusammenhang mit dem Gefäßumbau bei der pulmonalen Hypertonie ist vor allem die Assoziation von mikroRNAs und des Bone Morphogenetic Protein Rezeptor Typ II interessant: In verschiedenen Formen der pulmonalen Hypertonie wurde eine reduzierte Expression von Bone Morphogenetic Protein Rezeptor Typ II auf Endothelien und Gefäßmuskelzellen gefunden. Durch spezifische Hemmung mittels AntagomiRs bieten mikroRNAs die Möglichkeit für einen potenziell kausalen Therapieansatz. MikroRNAs werden zudem als Biomarker im Serum für Diagnose, Schweregrad und Prognose der pulmonalen Hypertonie validiert. Whereas pulmonary arterial hypertension is an orphan disease, the term pulmonary hypertension includes several common entities and is of major clinical significance. The pathophysiological triad of vasoconstriction, microthrombosis and vascular remodeling is found in most forms of pulmonary hypertension, independently of the underlying etiology. In this review, novel aspects in the pathogenesis of the remodeling, in particular microRNAs, will be discussed. MicroRNAs are small RNA fragments which bind specifically to the mRNA of a target gene thus decreasing its stability or inhibiting further translation ("gene silencing"). Of major interest is the association between microRNAs and the expression of bone morphogenetic protein receptor type II which has been found to be dysregulated on pulmonary endothelial and vascular smooth muscle cells in several forms of pulmonary hypertension. The specific inhibition of microRNAs by antagomiRs makes microRNAs a potential therapeutic target. Moreover, microRNAs are being validated in serum as biomarkers for diagnosis, severity and prognosis of pulmonary hypertension.
Conference Paper: Changes in plasma concentration of miR-17-5p and miR-335-5p in response to continuous positive airway pressure therapy withdrawal in obstructive sleep apnea patientsJahresversammlung der Schweizerischen Gesellschaft für Pneumologie (SGP) 2014, Interlaken, Switzerland; 05/2014
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ABSTRACT: Pulmonary hypertension is an "umbrella term" used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension. This review summarizes the latest clinical and experimental developments in inflammation associated with pulmonary hypertension with special focus on Interleukin-6, and its role in vascular remodeling in pulmonary hypertension.Respiratory research 04/2014; 15(1):47. DOI:10.1186/1465-9921-15-47 · 3.09 Impact Factor
Article: Diagnostik, Therapie und Prophylaxe von respiratorischen Viren bei lungentransplantierten Patienten (Diagnosis, Therapy and Prevention of Respiratory Virus Infections in Lung Transplant Recipients)[Show abstract] [Hide abstract]
ABSTRACT: Am Universitätsspital Zürich werden seit mehr als 20 Jahren Lungentrans-plantationen durchgeführt. Die Lungentransplantation stellt eine etablierte Therapieoption im Endstadium nicht-maligner Lungenerkrankungen dar. Verglichen mit den Langzeitverläufen anderer solider Organtransplantationen sind die Ergebnisse nach Lungentransplantation allerdings schlechter: Das mediane Überleben beträgt derzeit etwas mehr als fünf Jahre. Die wichtigste Langzeitkomplikation ist die Entwicklung einer chronischen Allograftdysfunktion (CLAD), meistens in Form eines Bronchiolitis-obliterans-Syndroms (BOS). Dabei kommt es über eine Entzündungsreaktion in den kleinen Luftwegen zu einem zunehmenden Umbau der Lungenstruktur, die sich spirometrisch in einer obstrukti-ven Ventilationsstörung mit progredienter Abnahme der Einsekundenkapzität (FEV 1) manifestiert. Die Ursachen eines BOS und seine Pathogenese sind nicht vollends klar. Trigger für Entzündungsreaktionen (wiederholte akute Abstossungen, respiratorische Infektionen) scheinen aber seine Entwicklung zu begünstigen. Lungentransplantierte Patienten sind anfälliger für Infektionen im Vergleich zu Transplantierten anderer solider Or-gane, ebenso ist die Auswirkung der respiratorischen Infektionen auf den Langzeitverlauf am grössten. Neben der oben erwähnten Komplikationen wie CLAD und BOS sind infektiöse Komplikationen unter ausgebauter Im-munsuppression gefürchtet. Ein Zusammenhang zwischen viralen Infektionen und Abstossungsreaktionen wird seit Jahren vermutet. Bisher konnte aber in keiner Studie eine direkte Kausalität zwischen einem bestimmten re-spiratorischen Virus und einer akuten oder chronischen Abstossung gezeigt werden. Die Entwicklung eines BOS scheint daher eher über (unspezifische) Entzündungsreaktionen als Folge einer respiratorischen Infektion als durch virusspezifische Faktoren bedingt zu sein.Praxis 04/2014; 103(8):453-459. DOI:10.1024/1661-8157/a001627
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ABSTRACT: Whereas pulmonary arterial hypertension is an orphan disease, the term pulmonary hypertension includes several common entities and is of major clinical significance. The pathophysiological triad of vasoconstriction, microthrombosis and vascular remodeling is found in most forms of pulmonary hypertension, independently of the underlying etiology. In this review, novel aspects in the pathogenesis of the remodeling, in particular microRNAs, will be discussed. MicroRNAs are small RNA fragments which bind specifically to the mRNA of a target gene thus decreasing its stability or inhibiting further translation ("gene silencing"). Of major interest is the association between microRNAs and the expression of bone morphogenetic protein receptor type II which has been found to be dysregulated on pulmonary endothelial and vascular smooth muscle cells in several forms of pulmonary hypertension. The specific inhibition of microRNAs by antagomiRs makes microRNAs a potential therapeutic target. Moreover, microRNAs are being validated in serum as biomarkers for diagnosis, severity and prognosis of pulmonary hypertension.Pneumologie 04/2014; 68(6). DOI:10.1055/s-0034-1365456
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University of Zurich
Zürich, Zurich, Switzerland
- • Internal Medicine Unit
- • Center for Integrative Human Physiology
University Hospital ZürichZürich, Zurich, Switzerland
Johannes Gutenberg-Universität MainzMayence, Rheinland-Pfalz, Germany
Duke UniversityDurham, North Carolina, United States
Duke University Medical Center
Durham, North Carolina, United States
- Division of Rheumatology and Immunology