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Genetics and Genomic Studies
in Scleroderma (Systemic Sclerosis)
Sandeep K. Agarwal, MD, PhD*,
Filemon K. Tan, MD, PhD,
Frank C. Arnett, MD
Division of Rheumatology, Department of Internal Medicine, The University of Texas Health
Science Center at Houston, 6431 Fannin, MSB 5.270, Houston, TX 77030, USA
Scleroderma or systemic sclerosis is an autoimmune connective tissue dis-
ease clinically characterized by fibrosis of the skin and internal organs and
obliterative vasculopathy. The complexities of scleroderma are evident from
the variability in its clinical manifestations, which probably reflects the
diverse mechanisms that underlie the development of disease subtypes.
Despite recent advances in the understanding of some of the molecular path-
ways involved in scleroderma, the etiopathogenesis remains unknown.
Although fibrosis and endothelial dysfunction are hallmarks of the disease,
autoimmunity is probably the root cause. Autoimmunity and inflammation
currently are best exemplified by the multiple but not overlapping patterns
of specific autoantibodies in patients who have scleroderma. In fact, each of
these autoantibodies tends to mark a distinct clinical subset of disease [1].
The presence of inflammatory infiltrates in the dermis early in the disease
and increased circulating levels of cytokines and chemokines in patients
who have scleroderma further implicate inflammation in the pathogenesis
of scleroderma. It remains unknown how these autoimmune responses
lead to certain patterns of organ damage that vary among different clinical
subsets of scleroderma.
It currently is believed that scleroderma is a complex polygenic disease
that occurs in genetically predisposed individuals who have encountered
specific environment exposures and/or other stochastic factors. The nature
of these genetic determinants and how they interact with environmental fac-
tors are areas of active investigation. This article discusses the evidence that
* Corresponding author.
E-mail address: firstname.lastname@example.com (S.K. Agarwal).
0889-857X/08/$ - see front matter ? 2008 Elsevier Inc. All rights reserved.
Rheum Dis Clin N Am
34 (2008) 17–40
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supports a strong genetic link to scleroderma. Also reviewed are the family
and twin studies that suggest a genetic component in scleroderma, and re-
cent genetic-association studies implicating specific genes in the pathoge-
netic triad of autoimmunity, endothelial dysfunction, and fibroblast
activation. Last, this article highlights recent studies in scleroderma that
use gene-expression microarray profiles seeking to identify pathogenetic
pathways in scleroderma. Together these studies implicate potential patho-
genetic mechanisms involved in scleroderma, which, it is hoped, may trans-
late into clinical utility, including determination of disease risk, diagnosis,
prognosis, and novel therapeutics.
Familial aggregation and twin studies
Determining that a disease occurs more commonly in families than in the
general population is a first step in implicating potential genetic contribu-
tions. Robust estimates of prevalence and incidence rates of scleroderma,
which are essential in determining familial aggregation, have varied widely
in the general population, ranging from 3.1 to 20.8 per 100,000 and from
0.4 to 1.2 per 100,000, respectively [2–5]. A recent, well-conducted study
estimated the prevalence of scleroderma to be 24.2 per 100,000 adults
with an annual incidence of 1.93 per 100,000 adults [6]. Initial reports sug-
gested that familial clustering was uncommon, but only recently has it been
quantitated [7]. Ten cases of scleroderma in first-degree relatives among 710
proband cases were reported in the Sydney, Australia population, confer-
ring a familial risk conservatively estimated at 11 (95% confidence interval
[CI], 2.7–19.3) [8]. It was demonstrated subsequently that scleroderma re-
curred in 1.6% of families of scleroderma cases in three separate cohorts
that had an estimated population risk of only 0.026% [9]. Although this ab-
solute risk of familial scleroderma was relatively low, the familial relative
risk was approximately 15-fold higher for siblings and 13-fold higher for
first-degree relatives. A recent study suggested that the affected members
within multicase scleroderma families tend to have concordant sclero-
derma-specific autoantibodies, further supporting the concept of a genetic
predisposition [10]. Based on these studies, a positive family history of
scleroderma confers the strongest known relative risk for disease.
The investigation of monozygotic twins is an important approach for
assessing and quantifying the role of genetic versus environmental factors
in specific diseases. Case reports have described concordance for sclero-
derma in twins [11,12]. Examination of 42 monozygotic and dizygotic twins
collected from across the United States demonstrated similar scleroderma
concordance rates (w5%), thus implying no genetic susceptibility [13].
The concordance rate of antinuclear antibodies was significantly higher in
monozygotic twins (90%) than in dizygotic twins (40%), however [13]. A
subsequent study compared gene-expression microarray profiles of cultured
fibroblasts from 15 discordant mono- and dizygotic twin pairs [14].
AGARWAL et al
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Unsupervised hierarchical clustering segregated cultured fibroblasts into
two distinct groups. Fibroblast lines from unaffected monozygotic, but
not dizygotic, twins tended to group with cultured fibroblast cell lines
from affected scleroderma patients rather than with normal controls. To-
gether, as summarized in Table 1, these data suggest that genetic factors
may play a significant role in susceptibility to scleroderma with regards to
the production of autoantibodies and in vitro fibroblast activation. Al-
though these data may partially explain the clustering of autoimmune dis-
eases observed in some families, it is necessary to define the genetic
factors that underlie scleroderma susceptibility.
Ethnic factors
It is apparent that ethnicity influences the susceptibility to autoimmune
diseases, including scleroderma. African Americans have been reported to
have a higher incidence of scleroderma (22.5 cases per million per year)
than white women (12.8 cases per million per year) [15]. Furthermore, Afri-
can American women have been reported likely to have more severe disease,
earlier age of onset, and worse survival rates [15]. Reveille and colleagues
[16] demonstrated in a prospective cohort that Hispanics and African Amer-
icans were more likely than whites to have diffuse skin involvement, digital
ulcerations, and pulmonary hypertension.
Among the more intriguing observations with regards to ethnicity and
scleroderma were those made in the Oklahoma Choctaw Indians [17]. The
prevalence in full-blooded Choctaws was estimated at 469 cases per
100,000 over a 4-year period. This prevalence was significantly higher
than that seen in non–full-blooded Choctaws, other Native Americans in
Oklahoma, and whites. Furthermore, a majority of the Choctaw sclero-
derma cases had diffuse scleroderma, pulmonary fibrosis, and circulating
anti-topoisomerase I antibodies and could be traced genealogically to a com-
mon founding family in the late 1700s. No environmental factors were iden-
tified in the Oklahoma environment, and the strongest risk factor was
a nearly unique Amerindian HLA class II haplotype (DRB1*1602,
DQA1*0501, DQB1*0301). Investigators using microsatellite markers in
Table 1
Estimates of scleroderma occurrence and risk in families
PopulationFrequency (%)
General population (prevalence)
First-degree relatives of persons who have scleroderma (prevalence)
Siblings of persons who have scleroderma (prevalence)
Monozygotic twins of persons who have scleroderma (concordance)
Monozygotic twins with antinuclear antibody–positive concordance
Monozygotic twins with fibroblast gene profile concordance
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Author's personal copy
three candidate regions found a shared haplotype on chromosome 15q con-
taining the fibrillin-1 (FBN1) gene, an important structural protein and reg-
ulator of transforming growth factor-beta (TGF-b) within the extracellular
matrix, to be significantly overrepresented in Choctaw scleroderma cases
[18]. Similar studies of single-nucleotide polymorphisms (SNPs) supported
a role for FBN1 in Choctaw and Japanese scleroderma cases but did not
show associations in whites [19]. Interestingly, a mouse model of sclero-
derma, the tight skin mouse (tsk-1), is caused by a genomic duplication of
fibrillin-1 [20].
These studies demonstrate the influence of ethnicity on scleroderma sus-
to health care, and even environmental exposures may help explain these dif-
ences among ethnic groups probably are key determinants as well.
Genetic factors
HLA associations
The major histocompatibility complex (MHC) or HLA region is the most
polymorphic region of the genome. Polymorphisms in HLA have been
linked to a number of autoimmune diseases including rheumatoid arthritis,
ankylosing spondylitis, systemic lupus erythematosus, and many others
[1,21–23]. Scleroderma also has been associated with HLA polymorphisms,
and these associations have been reviewed previously [24,25]. The associa-
tions of HLA polymorphisms with scleroderma susceptibility itself are mod-
est but, more importantly, are consistent and are reproducible across
different populations; these include associations with the HLA-DR5/11
and DR3 haplotypes in white patients and with HLA-DR2 haplotypes in
Japanese and Choctaw Indian patients. Of particular interest is a finding
of a significantly higher frequency of HLA-DQA1*0501 in male patients
who have scleroderma [26].
Stronger associations with HLA haplotypes exist for specific autoanti-
body subsets of scleroderma, including HLA DRB1*1104 and, indepen-
dently, DPB1*1301 in whites, DQB1*0301 and DPB1*1301 in African
Americans, and DR2 haplotypes in Japanese (DRB1*1502, DQB1*0601,
DPB1*090) and Choctaws (DRB1*1602, DQB1*0301, DPB1*1301) with
anti-topoisomerase antibody [27–32]. Furthermore, HLA DQB1*0501 and
other DQB1 alleles encoding nonpolar amino acids in position 26 are asso-
ciated with anti-centromere antibody [27,33]. An association of HLA
DRB1*1302, DQB1*0604/0605 haplotypes has been found with anti-fibril-
larin (anti-U3-RNP)–positive patients, who are more often male African
Americans, and the HLA DRB1*0301 haplotype has been shown to be as-
sociated with anti-PM-Scl antibody positivity in patients who tend to be
nearly exclusively white [34,35]. Finally, an association was observed with
AGARWAL et al


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What the hell is lossless audio? #15
Yes I am sure the "Sony should give up" and "If Sony wanted to bury the PS3 they should have said so" and Sony is out of the loop" and "Sony is doomed articles" that were everywhere were just a dream that we "Sony fanvboys" made up too? You must be new here. Sony was attacked from all sides the moment the PS3 was born despite the fact that it was more than worth the price. And ever since all of it's games and Sony's decisions are met with m... #19.2
I suppose. Still sore at you Sony. I was all prepared to play LBP2. But I guess i would rather a delay then a buggy non functional game.Sigh #15
First of all I don't know why you people still answer bigpappy. Secondly I read a preview from Joystiq that said it works a lot better then the E3 version, so I am confused to see it not working. Finally i will wait until the final game to pass judgment. I know people still try to play it like a Wii boxing and flail around because gamers are stubborn and refuse to listen that Move is different so it wouldn't surprise me in the least if it is fully functional and it's just some gam... #15
Awwwwwwww!!!!! I wanted LBP2 NOW!!!! *stomps foot* No fair!!!!!!. Seriously Sony this is not good. I didn't want to have to choose between certain games. Now I have more then ever to choose from next year. I understand that you need to make it shine but I don't like this one bit. #28
Awwww!!!! That's so sweet. Every third party developer and console company is so concerned about Sony these days. That is so cute.Well i think that Sony is a big boy now and old enough to decide what path they want to take with their technology. If they listened to what everyone they wouldn't have the PS3 Slim, the Move or be catching up with Microsoft by only a few million or have the epic first party games we have now. Why don't you just concentrate on your own companies and sto... #25
Nothing will Kill KZ3 for me. It's amazing how PS3 games always get so much scrutiny before and after their release.I have lost count of how many glitch and problem videos I have seen for GT5. #23
Probably get tons of disagrees for this but from what I have seen Kinect's line up looks pretty weak to me. There killer app seems to be a dance game and all though Move does have shovelware, Kinect is all shovelware. Show me one game in their current line up that doesn't look like grade A shovelware? Now look at Move. Does The Fight look like shovelware to you? Does Socom look like shovelware? Does Sorcery look like shovelware? Or Endochrome 2? Or Undersiege? And these games are righ... #9
That's right. That is why it took so long. I couldn't be that Sony takes their time with everything which is why they didn't make a RRODing, disc scratching, easily hacked piece of crap of a console.No of course not it makes more sense that they were researching it, decided to stop, saw the Wii was doing well, picked it back up, dusted it off and used magic to make it work better than then Wii ever did and with 1:1 add in augmented reality and HD into the mix about 5 years later t... #28
dchalfont I know some doofus had to say exactly what you just said and you said it. Haters are so predictable. Anyway copying the 3DS is a bad idea. Do you want make Nintendo fans to cry more? They have already cried pools of tears non stop since the Move has been getting good reviews. If Sony tops the 3DS with the PSP2 and 3D they will wail until the end of time. Don't do it Sony. For our sanity's sake. I can't take another 'Nintendo made it first and that's all that matt... #25
Apocalypse Shadow don't waste your breath. Logic is something gamers don't use these days. All they care is that the system they are backing wins and the other loses. The end result Anything else in between like quality, performance, the truth, concern, logic, your own eyes or even common sense be damned. #17
That was a horrible pun. You should be ashamed. Anyway I don't think Sony is focusing on beating the Wii right now. It's Kinect they have to kick to the curb first then take on Wii. They have a head start,an ad strategy, despite what anyone says a varied game line up, cheaper games and have plenty of third party support due to fact that you can intergrate Move easily into their games. Yep. I think they can do it. #6
@ theafroman. Move's line up is bad? So Kinect's all simplistic, no variety shovelware line up is better? How does that make sense. @ Imperator that is why Sony and Nintendo refused the tech. What is the point swinging your hand to play table tennis when you can have a controller to grip on to. People don't understand that Sony and Nintendo have been doing the whole game thing longer then Microsoft has. They know what they are talking about. Compared to them Microsoft are amateurs. #9
Oh well that proves everything. Hey judge I think Sony kind of advertised the other OS and I think lots of people used it because there might be more people who aren't saying anything because they think Sony is going to find where they live and eat them up. The people who say it's not a problem are obviously fanboys because everyone else who attacks everything that Sony does and blow it out of proportion have to be telling the truth. It couldn't be that we are sensible enough to s... #21
People don't seem to realise that Sony has always catered to both sides and the Move is no different. Shooters, RTSs,puzzles, platforms, adventure etc. It all there. No matter how you try to lie to yourself or put a nice little spin on it or try to deny it, nothing has changed. Microsoft: hardcore. mainly shooters and sports games, Nintendo: casual. mostly mini games, platformers and shovelware. Sony: both sides. games for hardcore and causal and everyone in between, has every genre cove... #14
360 owners don't really have much of a choice. They are already in Microsoft's trap and they don't even realise it. You have to pay for Live because most of Microsoft's games are based on multi player. If they gave you more games with a stronger single player, you could ignore Xbox Live if you feel that it is getting too expensive but you need Xbox Live to experience the whole game or your just stuck usually playing 3-5 hour single player. With a PS3 you could ignore online a... #25
You mean like Microsoft fanboys who sat for 3 years watching Microsoft trying to fix a glitch as 30% of their systems died and still brought new ones when they died and still rushed out to buy the slim and pretended it didn't happen and try to shut up anyone who reminds them of it? That is pure blind fanboyism at it's best. Other people would have boycotted the 360 but you guys bent over for three years and took up the tail pipe without even taking a break. And now even taking the $10... #17
Yes I agree. You people should wait for Kinect. You have so many games. Ummmm. Oh yeah. The dance game and the dance game. oh yeah and the other dance game. And the invisible animals game. Oh yeah how could we forget the Sonic Riders game that was crappy even with the controller. And the ugly racing game where you press pedals with your hands, oh yeah and the other dance game.And that awkward fighting game and the soccer game where you can't run around and you stay still like a statue. Wo... #4
First of almost no one used it. Trust me. Most people I know didn't know it existed. Second of all correct me if I am wrong but the contract that you agreed to says that Sony hss the right to change something on the PS3 when ever they feel like it (just paraphasing). Third Sony has the right to protect their investment and this is just the usual case of people trying to cash in on someone's success by acting like the leeches and sponges they are.Ordinary people are greedy too not just... #11
Yeah. I think I heard that it was delayed in Japan too not the U.S. #4
1841d ago by tiamat5 | View comment


text: Mashup: Rotational velocity Comments Share via FacebookShare via TwitterShare via LinkedinShare via Google+Share via RedditShare via Mail Rotational velocity of a point on the surface of the Earth. Track this Mashup Submit a mashup Summary Comments Followers Summary Comments Followers Comments (1) Comments(1) Comment * Leave this field blank Post Comment luntereiner 4:15 AM Sep. 04 2012 reply Nice app ! Do have an idea of the plugin used for the tour when you are logged in the app ? Probably a js plugin incorporated in Drupal... Any idea ?


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On a day that President Obama touted his administration's efforts to save the U.S. auto industry, Judy Woodruff assesses the state of the industry with Micheline Maynard, senior editor of Changing Gears, a new public media project focusing on the future of the industrial Midwest, and economist Martin Bailey. Continue reading
Correspondent John Merrow reports on the progress of Detroit's public school system, following last year's tumultuous takeover by the state of Michigan, following allegations of corruption, a $316 million hole in its budget and tumbling enrollment. Continue reading
Nine people with ties to a Christian militia group have been charged in an alleged plot to murder police officers and target their funerals following FBI raids in Michigan, Ohio and Indiana. Margaret Warner talks to a reporter in Detroit about the charges. Continue reading
A roundup of arts headlines.
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Tom Bearden looks at how some Midwestern states are battling the threat of carp overpopulation, which is damaging the Great Lakes' fragile ecosystem. Continue reading
A roundup of art headlines.
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Michigan is home to few bright economic spots these days — with the exception of the college town of Ann Arbor. Ray Suarez reports. Continue reading
As the Obama administration contemplates how to close Guantanamo Bay prison, residents in the small town of Standish, Mich., are considering whether to support one plan under consideration at the White House that would bring suspected terrorists to a local prison. Continue reading
With less than six months until President Obama's deadline for closing the detention facility at Guantanamo Bay, the White House is struggling to decide on a bevy of options. Ari Shapiro of National Public Radio speaks with Judy Woodruff about the various options under review. Continue reading
The Obama administration is considering whether to establish a joint courtroom-prison complex in the United States to house the 229 suspected terrorists being held at Guantanamo Bay, the Associated Press has reported. Continue reading


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by TrustedReviews
27 October 2011
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San Francisco's Laguna Honda Hospital is the last almshouse in the country, a descendant of the Hôtel-Dieu (God's Hotel) that cared for the sick in the Middle Ages. Ballet dancers and rock musicians, professors and thieves — "anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care — ended up there. Dr. Sweet ended up there herself, as a physician. And though she came for only a two-month stay, she remained for twenty years.
In God's Hotel: A Doctor, a Hospital, and a Pilgrimage to the Heart of Medicine Dr. Sweet lays out her evidence—in stories of her patients and her hospital—for some new ideas about medicine and healthcare in this country. In trying to get control of healthcare costs by emphasizing "efficiency," we've headed down a wrong path. Medicine works best—that is, arrives at the right diagnosis and the right treatment for the least cost—when the doctor has enough time to do a good job, and pays attention not only to the patient but to what's around the patient.
God's Hotel is the On the Same Page selection for January/February 2014. Readers Books will sell books at the event.
God's Hotel is the On the Same Page selection for January/February 2014. Readers Books will sell books at the event.
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Chimney Flame is a movable unit for use in fireplaces and burns using bio-ethanol, making sure your fireplace does not get dirty while you enjoy the flair of an open fire.
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|Fuel Type: Ethanol fuel
|Adjustable Flame: Yes
|Fireplace Placement: Tabletop fireplace
|Finish: Black
|Material: Glass
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|Gloss Finish: Yes
|Plug In: No
|Number of Burners: 1
|Fuel Capacity: 57.48 Ounces
|Air Filter: No
|Snuffer Included: No
|Assembly Required: Yes
|Additional Parts Required: No
|Product Warranty: 10 year operational guarantee
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text:
Valtteri Bottas News
Rachel Brookes discusses Williams' chances of beating Ferrari in Japan with Valtteri Bottas and how he rates his 2015 performance.
Williams chief technical officer Pat Symonds admits he doesn't know if the team will run Mercedes' upgraded engine during 2015.
Claire Williams says Williams must deliver a car Valtteri Bottas can win races in to persuade him to stay for more than one year.
Felipe Massa and Valtteri Bottas will stay as team-mates after Williams confirmed an unchanged line-up for 2016.
Predicting the line-ups of the F1 teams in 2016 after Ferrari retained Kimi Raikkonen. Cue the status quo or could there be some surprises?
Rob Smedley says Williams need to look at how they approach the start of races after early tyre graining issues at Spa.
Valtteri Bottas has slammed the "unnecessary" and "unfair" rumours which have swirled about his F1 future in recent months.
Valtteri Bottas admits the speculation surrounding his future and a potential move from Williams to Ferrari is disturbing.
Sky F1's Martin Brundle, Damon Hill and Mark Hughes review the performances of all 20 drivers in the first half of 2015...
Williams have admitted that they should have won the British GP but for a race-wrecking tactical mistake.
Valtteri Bottas says he "believes in the future of Williams" but has fallen short of committing his own to the team.
Italian media claim Ferrari have agreed a deal with Williams to release Valtteri Bottas for 2016, but no driver contract yet signed.
Assessing the contenders to partner Sebastian Vettel at Ferrari in 2016 as speculation over Valtteri Bottas intensifies.
After going from running one-two to finishing off the podium, Rob Smedley faced the media to try to defend Williams' strategy.
Valtteri Bottas has high hopes that Williams can still challenge for the top three on the grid in Austria despite their low-key Friday.
Valtteri Bottas is optimistic Williams can be "really close" to Ferrari at the Austrian GP if their upgrades work as expected.
Valtteri Bottas reckons he can take the fight to Kimi Raikkonen in Montreal after qualifying fourth behind fellow Finn.
Williams' chief technical officer Pat Symonds says the team are not in a position to win races this season.
Pat Symond's isn't surprised Valtteri Bottas is attracting the interest of other teams, but hopes he will stay at Williams.
Valtteri Bottas has admitted he was surprised by Williams' performance relative to Ferrari in Spain given their limited upgrades.
|Lewis Hamilton
|Nico Rosberg
|Sebastian Vettel
|Kimi Raikkonen
|Valtteri Bottas


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Today I ran a half marathon, or a 21.1 kilometer race. It was hosted by the Irene Sports Club in the Irene farming land of Gauteng. 267 more words
Tags » Peace Corps South Africa
Lions and Tigers and Bears - Oh my!
Sometimes I can't believe the types of opportunities life throws at me.
When I was younger I was like most kids- overly excited about the zoo and the idea of getting to see animals that I normally would never get to see. 1,975 more words
Nelson Mandela Day.
I'm not all that great at interneting, but I'm trying my best to keep you loverfaces updated! Here's a breifing on Nelson Mandela Day! South Africa has a national holiday to celebrate Nelson Mandela- more specifically, to commemorate his 67 years of service to his country by giving 67 minutes of your day to provide a service to others. 156 more words
Two Whole Years
If you've been following my blog, talking to me on Whatsapp, looking at my Facebook posts or watching my Snapchat stories, you'll know that my experience as a Peace Corps Volunteer in South Africa has been a ton of fun. 310 more words
Map Attack!
A common project for Peace Corps Volunteers in South Africa is the world map project. Oftentimes in the rural villages where we live, children and families are blissfully unaware of where in the world they are, making it even more difficult to comprehend where in the world we PCVs come from. 443 more words
The fear is exciting, and the challenge is enticing.
I was contacted by an ultrarunning website – called Ultrafinishers – to speak on their weekly podcast about running… 144 more words
Snail Mail
A beautiful component of my Peace Corps service has been the tremendous support I've received from family and friends around the world. This support has come in a myriad of ways, some more expected (Facebook posts, Whatsapp messages, pictures on Snapchat) and some less (donating pens, contributing to… 633 more words


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You may follow today's political news, but how much do you know about presidential politics through history?
Classroom lecture vs. rock concert.
That's one way to quickly characterize the difference between a campaign stop for Hillary Clinton and Bernie Sanders.
When Democrats visit political events for these two presidential candidates, it's a markedly diffe...
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I Am Queer
Personal Stories, Advice, and Support 514 People
2 women in my Facebook I think are into me.One says I'm cute a lot which could be how she talks. Who knows? The other one lives too far away. Awkwardness. I'm on asexual spectrum. And am gender queer. A man from the past is messaging me now. I think he still likes me, might even still love me. Sometimes I like attention...
NotApplicable 22-25, F 1 Nov 10, 2014
Is a 19 year old female too youngfor me? For dating and stuff. We really get along and agree on most things. I'll just play it by ear. If she's immature I'll stop.
NotApplicable 22-25, F 2 Responses 0 Dec 30, 2014
I'm Queer!I'm just sitting in a Women's Studies class and got inspired. I've struggled with defining myself and finding where I fit in this world for a long time. At one time I thought maybe I'm trans, I said that I was bisexual for a long time, ecetera. Nothing ever felt right though...
Callisto24 22-25 1 Response 3 Feb 13, 2012
My real name is Bradand I am 58. I call myself Roxi....I will try and be quite honest and candid with you....I was asexual when I was growing up and going to school....I think most people (in school) were asexual, THEN....
roxyehh 51-55 0 Apr 14
Sounding The All Queer SignalHi ladies, gents, womyn, bois, cis-, trans, and everyone who is not heteronormative! I'm queer. I'm out. I've been out since I was 14, so that's nearly twenty years now. If you want to get down to the three main categories of sexual attraction, I'm bisexual. I'm more...
twelvetwelve 36-40, F 3 Responses 6 Apr 1, 2013
This Is How I Came Out ...So I guess when I start thinking about my sexuality and it's manifestations, I feel like I should have know when I was little that I was going to be a little weird. I remember being young (like a little little kid) and playing house/doctor, whatever it's called, with my little...
Pachis 22-25, F 3 May 8, 2013
My experiences about figuring out my genderand sexuality keep getting deleted. I feel a little attacked because I'm not breaking any of the guidelines (I just re-read them to make sure). My gender and sexual orientation should not be something that is getting blocked on this website. I came to EP a few years ago...
StrangeDarkSecrets 16-17, T 1 Response 1 Nov 7, 2014
Just Queer.Earlier tonight I opened up Word and started typing. I want to understand myself, I want to learn to be happy, learn what I want in life and then find a way to make it happen. Over the course of writing, I came to a lot of new conclusions. Thus far, it's helping and I feel...
themegaloo 22-25 4 Responses 4 Aug 10, 2011
"queer"I always think it's funny when I get called "queer" because for me living any other way would be strange, and just disgustingly awkward. I have never even considered being with a guy, and have always felt attracted to girls. I am masculine and have always been...
Blizzake 22-25 0 Oct 21, 2009
Just in the fact that I have a very oddsexuality. Romantically, I identify as panromantic. I feel like I could be in a loving relationship with just about anyone, regardless of who they are or what they identify as. Sexually, I feel like I'm homosexual, but I'd be willing to be with a man(cis in particular) if I...
Inadine 16-17, F 1 Response 0 Aug 5, 2014
Getting to be really pissed about how manyLGBT+ areas are made to cater to cishets. Allies need to stop.
CincinnatiSubway 18-21, T 1 Response 2 May 25, 2014
Fun thing about Hispanics,Cubans specifically is that they are perverted as hell but also weirdly religious. They curse and talk about their crotches but the idea of being gay or trams is totally taboo. Maybe it's the machismo bullshit. Hypocrites these folks are hypocrites. This is coming from a Cuban...
NotApplicable 22-25, F 2 Aug 19, 2014
Christina HendrickssssssssI used to play Sailormoon in grade 1 and I'd always be Tuxedo Mask. "Playing" included lots of making out with my best friend who happened to be a girl. When her mom found out, she told me go home and brush my teeth because kissing is gross. In middle school, I was often...
aaureolee 22-25 1 Response 0 Mar 11, 2013
I am queer and gender nonconforming.Sometimes I don't know whether I feel like a masculine girl or a feminine boy.
Kaitowonder 26-30, M 2 Responses 1 May 3
I Wont Say I Ambut definatly different like how many guys do you know that dont own any guys trousers socks or underear? they are all womens and i love it
christinemelody 56-60, T 1 Response 1 Jun 3, 2013
Happy QueerI love men and always have and I believe the its ok to be gay, because I was born queer and when I was little I liked boys and now I love guys, I believe same sex marriages, t our right to love who ever u want!! Also its so nice when two people fall in love for love,so I am...
Happyqueer50 46-50 1 Jan 20, 2013
Queer Little Me <3There's nothing in this world that i would rather be than queer little me! I remember juggling the labels around in this circus called my life and thinking to myself I would so rather be the bearded lady... but enough of that seriously college was the biggest coming out and...
Nerd6986 26-30, F 1 Aug 25, 2012
sassycastiel 18-21, F 1 Jun 7
It Feels Rather Good To Say "i'm Queer"So, yeah. I'm queer. You know, the first time I openly acknowledged it was in the counseling office a few days ago. Weird, eh? Well, yeah, I told my counselor about my first--and so far only--relationship with a girl. It lasted all of two months, but I mean it was pretty friggin...
alponder 22-25 2 Responses 2 Mar 16, 2012
THE Girl Gotta Girlfriend..pls comment..updatedT o make a long story short...theres this girl at my job.... she was the 1st sexy female that I saw on my 1st day at work. I never said anything to her cuz everytime we walk past each other we're both on the phone n plus I dont get to see her that often cuz we work different...
phillyzbossfemme 18-21, F 2 Responses 2 Aug 17, 2008
Hi all! This is my first time back on this sitein a while. I'm changing a few things up, as some are a bit inaccurate nowadays, but my experiences remain the same. If anyone would like to connect, shoot me a message :)
ActWriteLive 18-21, F 1 Dec 27, 2014
What Did I Do Wrong In My Life That I Am The Person I Am In This Moment?What is wrong with me? I had this new years that was and experience for me, I had encounter with a guy (FTM) and we hit it off , would walk away from dance floor to go kiss and make-out. Days later we are chatting to each other and I am trying figure out for me who i am as...
AcadStudent 22-25 0 Jan 4, 2012
I didn't choose the queer life.The queer life chose me!
NotApplicable 22-25, F 3 Aug 28, 2014
Loud & proud! For so long I was treatedso poorly by my family & peers. They though I was SO weird. Then when everyone got older they thought I was "interesting" lol funny how that happens. People still think I'm weird but when on doubt, freak em out!
Aphilli00 22-25, F 1 Apr 3
FYI: the only personwho can determine what labels and identities are valid and applicable to you is yourself. Don't ever let someone try to question or erase your identity. You deserve better.
InhuldibleCrelk 36-40 3 Aug 24, 2014
Being A Bit Left OutI am bisexual - I have interest in both male and female. Due to this, putting on comments to both sex is very natural for me, but things are bit conservative in my neighborhood. I didn't make a coming-out to anyone yet, so people look on me as a bit sensitive person, or sometimes...
fraudi 22-25 0 Aug 18, 2013
WeirdI am queer. I am not a homosexual because I have loving relationships with those who identify as male. I am not bisexual, because bi means two and there are more than two genders. Queer means many things. It has allusions to political activism, and it is a word that we had to...
silvermoon 31-35 2 Responses 3 Oct 29, 2007
I'm a gender weird Panromantic Pansexualand love it!
borderlinecassandra 16-17, T 2 Jan 29
I Am Queer, But I Haven't Acted On It.I never thought I was going to act on my queer feelings because I've been in a heterosexual relationship for the last 4 years and I want it to last forever. But lately my partner has introduced the idea of opening our relationship physically to same sex relations, especially for...
marisatw 22-25 1 Response 0 Aug 20, 2013
PanladyI am Bella. I identify as pansexual or queer, and i just got out of a long relationship with a man. Im starting college in the fall and I'm so nervous about creating an identity all over again. Im also craving someone with really positive energy who understands my casual way of...
bella1james 18-21, F 0 Mar 5, 2013
I need advice. I'm socially awkwardand gender weird. think this gal is interested in me. She's same age as me. It seems that I don't choose the people in my life they kinda just show up. She said I was cute and touched my hair. I said "I'm not a poodle." She laughed. She asked for my number. She might just be...
NotApplicable 22-25, F 1 Response 0 Oct 12, 2014
If you haven't read Every Day by DavidLevithan, I'd highly recommend it. It's narrated by A, who is seemingly non-binary.
InhuldibleCrelk 36-40 1 Aug 29, 2014
Women are so friendly I can't tellif they're gay for me or just being nice or maybe they're just weirdly comfortable around me. Who knows? I'm autistic. It's hard to read people. So the "gayarde" I do not have.
NotApplicable 22-25, F 1 Jan 3
some men mostly noncis menbut lesbian isn't right but I actually don't know haven't dated in a while.
ladeputy 22-25, F 1 Response 0 Nov 8, 2014
I wear short, shorts all the time I have verygood-looking legs like to show them off.
Rossie1703 26-30, M 4 Responses 10 Sep 20, 2014
Queer doesn't mean "don't label me," it means "I am naming myself." It means "ask me more questions if you're curious" and in the same breath means "**** off."
InhuldibleCrelk 36-40 1 Aug 23, 2014
I recently came out to some of my closer friendsas being nonbinary, more specifically as an agender demigirl. I guess I was surprised at how accepting they were and how readily they switched to they/them pronouns by my request. I just feel very loved and I'm glad I have them. I realize that as a dfab individual I won't...
CincinnatiSubway 18-21, T 1 Response 2 May 24, 2014
Can I Be Queer?I am going to lay it out there and see where the chips fall. I am a 24 year old man and have been with my partner (female) for 8 years. I enjoy sexual activity with her and I have fathered a son, for whom my love knows no end. However, I am living a lie. I am attracted to men...
queeraz 18-21 3 Responses 5 Feb 13, 2008
Cryingsmile 16-17, T 4 Responses 3 Jul 23, 2014
Related Experiences
I like chicks, but I don't know if I'm actually gay lol. I guess you could say queer. Bet yeah, lesbians are great! So if y'all wanna hit me up go ahead XD jk, but really tho I...
CyborgNinjaz 13-15, F 0 4 hrs ago
A poem for the weird and strange, for the queer and deranged. A word for the sick and twisted, something for the sad and wicked. Know that you are not alone, and words can't hurt...
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A poem for the weird and strange, for the queer and deranged. A word for the sick and twisted, something for the sad and wicked. Know that you are not alone, and words can't hurt...
Dahlia86 26-30, F 0 3 days ago
they told me i could be whatever i wanted to be when i grew up..... so i became a raging genderweird queer. probs not what they had in mind ;p
jessaboo2 18-21, T 3 Responses 10 3 days ago
OK, confession time: I said in my previous Story that I have a congenital thyroid condition and that - among a couple of other medication (one of which I no longer take) - I take a...
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(US, slang, Northwest) A Car.
Some guy: That's a real boss hoss.
Some other guy: It sho is.
Some other guy: It sho is.
от Derwos 11 септември 2011
One who is a Bad Ass that can basically do anything he wants. He is usually loved by all and a ladies man. Also, a name for a friend, or to describe a friendship. Hoss is a compliment. Plural form Hosses.
Mihalik is such as Hoss. He destroyed his competition in track and picked up the hottest girl in school.
Matt and Sean are hosses. They're always tearing shit up together.
Matt and Sean are hosses. They're always tearing shit up together.
от TeamSolid 02 юни 2011
A hoss is a level higher than a boss. In other words, the guy who gives orders for others to give orders in order to give other people orders and so on and so forth. If you are a hoss, you are a level one beneath God. A hoss is pretty much a divine, or glorious, bad ass mother fucker.
George Washington was a hoss as he whooped Englands ass and lead America into a state of supreme glory. (boss) (bad ass Mofo) (leader) (winner) (overlord)
от Hammy the Glorious 30 май 2011
putting in a large dip or chew,chewing tabacco
oh man i could go for a big hoss right now
от woodfield 28 април 2010
A point in time when a person, place, or thing's potential is at its most, and that potential is acted out in a way that causes astonishment, disbelief, or an unpredictable event. It is when the act is completed that they are considered "hoss"
PERSON: Did you see what that guy did? What a hoss!
PLACE: Cancun is a hoss place to go to for spring break.
THING: Katrina was a hoss storm that caused unimaginable carnage.
PLACE: Cancun is a hoss place to go to for spring break.
THING: Katrina was a hoss storm that caused unimaginable carnage.
от Wes, Zach, and Jesse 10 ноември 2008
An alternative word for the substance Ketamine
My mate Jamie loves his hoss
от Grandmaster Hoss 20 август 2008
An overly large animal.
My dog is a hoss.
от Ronnie K Dea 14 август 2008


text:
I'm using gnubiff 2.1.8 on Ubuntu Dapper (so gnome
2.14.2) and I have a gnubiff icon in the notification
tray (not the floaty applet thing).
When there are no messages on initial load gnubiff
shows no new messages. When a new message is detected,
gnubiff shows new messages. When I've read the message
gnubiff never detects that the message has been read,
or simply chooses to ignore the fact. I must click the
"mark mailboxes read" context menu item to force
gnubiff to not show new messages.
I hope this isn't by design and is a bug. Gnubiff
should not show new messages when there aren't any.
Ryan Hayle
Logged In: YES
Originator: NO
I encounter this issue on my Gmail account. It is not present on my other email accounts using Courier-IMAP. This must be due to differences in IMAP server implementations. I don't know if it is a bug with Google's IMAP server, or whether Gnubiff is interpreting the response wrong, but I do hope it gets fixed soon. It is quite annoying. I am willing to provide any server debugging necessary.


text:
Positive Economic News
Posted: 02/17/2010 - Housing construction, and industrial production are up in January
Posted: 02/17/2010 - Housing construction, and industrial production are up in January
Posted: 02/17/2010 - White House says Taliban capture is a "big success"
Posted: 02/17/2010 - Billed as a boost to the local economy
Posted: 02/17/2010 - Dieter Zetsche given another four years as head of Daimler AG.
Posted: 02/17/2010 - Jurors claim racial dispute in deliberations made a verdict impossible.
Posted: 02/17/2010 - Farmers from across Michigan are donating 500,000 eggs to help feed earthquake victims in Haiti.
Posted: 02/17/2010 - Granola bars and several salami products are being recalled because they could be contaminated with Salmonella.
Updated: 02/17/2010 - Multi-vehicle accident near I-496.
Updated: 02/17/2010 - Money will go toward creating a center for the joint study of natural and digital evolution.
Posted: 02/17/2010 - Toyota is looking at complaints of possible power steering problems with the Corolla.
Posted: 02/17/2010 - Raising the State's gas tax could be one solution for an underfunding transportation budget.
Updated: 02/17/2010 - Ingham Intermediate School District is looking to make more cuts.
Updated: 02/16/2010 - Under Gov. Granholm's propsed corrections budget, inmates could be released early for good behavior.
Updated: 02/16/2010 - A mother and her boyfriend are accused of abusing and killing her two-year-old son in Jackson
Posted: 02/16/2010 - President Obama is looking for someone to manage his Twitter account, as well as his Facebook & MySpace pages.
Posted: 02/16/2010 - Vice President Joe Biden is in Michigan taking a firsthand look at what's being done by the billions in federal stimulus dollars
Posted: 02/16/2010 - King Tut reportedly died from malaria and a broken leg
Updated: 02/16/2010 - Mich. lawmakers are reviewing Governor Granholm's budget today in the latest budget proposal.
Posted: 02/15/2010 - For days people have watched the greatest athletes in the world compete at the Olympics. That competition has inspired some to try the sports for themselves.
Posted: 02/15/2010 - Many senators say they no longer love their jobs.
Updated: 02/15/2010 - The Making Work Pay Tax Credit is giving some tax filers an extra $400 in their returns.
Updated: 02/15/2010 - Some hockey goalies, including local Ryan Miller, will be wearing masks made in Port Huron
Posted: 02/15/2010 - Fire crews responded to a small fire on the roof of GM's Delta Township plant Monday afternoon. No evacuations were necessary, and production was not interrupted.
Updated: 02/15/2010 - Thirty-five passengers were about to takeoff when a man lunged for the door and tried to get off the plane.
Posted: 02/15/2010 - A Marine from Michigan who would have turned 22 on St. Patrick's Day has been killed in Afghanistan.


text:
editor's review
buy now £45.00
Rummage is a tool created for programmers and developers who want to protect their work by means of obfuscation. With this application you are able to prevent code theft, hacking, re-use and decompilation.
Comprehensive interface and easy to use
Rummage is made to run right out of the box, meaning that you don't have to walk through a long list of techniques to use and steps to configure. It doesn't even require an installation process.
To get started, all you need is to locate and load the assembly into the application, set the destination path for the new file, choose a few settings and then start the process. If you've done this before and are familiar with how things work, then everything from start to finish should take just a few minutes.
Create a custom obfuscation profile
Depending on the level of protection you're looking for, you are able to create a personalized obfuscation task. The profile can be given a custom name and are able to choose which obfuscations to apply.
Rummage gives you the possibility to remove unnecessary metadata and unused types or members, mark types as public, un-nest eligible nested types, mask custom attributes, rename members and encrypt strings.
Get detailed reports
When obfuscation is complete, the application displays a summary with a count for all the performed and skipped processes that were tied up to the applied changes. Moreover, you also get to save the obfuscation map in XML format.
Regarding renamed members, Rummage provides a complete list with all of them in which you can view the exact modifications. Since not everything is modified, what Rummage leaves untouched is presented with an explanation as to why.
Simple obfuscation solution
On a closing note, Rummage enables you to effortlessly obfuscate assemblies in a straightforward manner without overcomplicating things.


text:
"It was a good experience for your resume. "
I worked at CRAssociates as an intern (More than a year)
It is pretty easy work if you are an intern.
The location is inconvenient. Work can be very tedious.
Other Employee Reviews for CRAssociates
"The beginning of my credentialing career "
RecommendsNeutral OutlookApproves of CEO
- Work/Life Balance
- Culture & Values
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at CRAssociates full-time (More than a year)
CRAssociates is where I began my career in credentialing, so I basically owe it all to them. If I had not been given the chance to learn this position, I wouldn't be where I am today
There are your basic cons at every job
Advice to Management
It's better to encourage than discourage
Helpful (1)
"Depends on your position "
Approves of CEO
- Work/Life Balance
- Career Opportunities
- Comp & Benefits
- Senior Management
An opportunity to be the difference in the healthcare provided to Veterans
very political and clique-y upper-middle management structure; commitment to quality care is fractured by this. Company owners are not in touch with quality issues in the field.
Advice to Management
spend some time looking at what's happening in the field


text: American College of Surgeons Member Services ACS Chapters Ohio Chapter Become a Member Become a Member Fellows (US and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members Fees and Dues Member Benefits About Member Benefits Fellows (US and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs FACS Artwork ACS Jewelry and Accessories Career Connection Update Your Profile Realize the Potential of Your Profession About Realize the Potential Call to Action Scholarships, Fellowships, and Awards Scholarships, Fellowships, and Awards Overview Health Policy Scholarships Scholarships for International Surgeons Research Scholarships and Fellowships Resident Scholarships Special Opportunity Scholarships and Fellowships Traveling Fellowships Surgical Volunteerism and Humanitarian Awards Jacobson Promising Investigator Award ACS Chapters About ACS Chapters CME Procedures for Chapters CME Procedures for Chapters Overview Step 1: 60 Days Prior to the Meeting Step 2: One Week (5 Business Days) Prior to the Meeting Step 3: Within 30 Days After the Meeting Step 4: 60 Days After the Meeting Step 5: Four Months after the Meeting Find a Chapter Chapter Meetings Schedule Chapter Partner Program Webinars Webinars for Chapters Overview CME: Top 10 Things You Should Know Protect Your Chapters History: Archiving 101 When Board Members Go Bad: Practical Aspects of Hard Problems Governors 101: Building a Partnership Using ACS Communities to Increase Chapter Participation Chapter Advocacy Governors Chapter Activities Workgroups How to Form a Chapter Chapter Guidebook Chapter News Resources for Chapter Leaders Resources for Chapter Leaders Overview Committees on Applicants Medical Student Toolkits Best Practices to Keep Chapters Running Smoothly Young Fellows Association Young Fellows Association About YFA Leadership Advocacy Workgroup Communications Workgroup Education Workgroup Member Services Workgroup Meetings and Events Mentoring Program Top 10 Reasons to Participate Resources YFA E-News Resident and Associate Society Resident and Associate Society About RAS-ACS Leadership Bylaws for RAS-ACS Advocacy and Issues Committee Communications Committee Education Committee Membership Committee Meetings and Events Top 10 Reasons to Participate Membership International Exchange Scholar Program Resources RAS E-News Operation Giving Back Operation Giving Back A Global Mission Opportunities Resources and Toolkits Surgical Volunteerism Awards Society of Surgical Chairs About SSC Join SSC SSC Membership Directory 2014 Annual Meeting Mentorship Program Outside Activities Outside Activities Overview SRC Liaison AAMC Council of Faculty and Academic Societies Organization of Resident Representatives to the AAMC Member Communities Military Health System Strategic Partnership ACS Archives Board of Governors Advisory Councils Contact Us Ohio ChapterOhio Chapter functions through the coordinated activity of its individual members, for the support and improvement of the practice of surgery in the state. With the help of an executive director, the Chapter relies completely on the energy and initiative of interested Ohio surgeons. We welcome the participation of any interested individuals. PO Box 1715Columbus OH, 43216-1925United States http://www.ohiofacs.org/ Officers James Robert Ouellette, DO FACS CoC State Chair|01/01/2015 - 07/01/2018 Nancy Lynn Gantt, MD FACS President|06/01/2015 - 08/31/2016 Walter Sun Cha, MD FACS President Elect|06/01/2015 - 08/31/2016 Cari Ann Ogg, MD FACS Treasurer|06/01/2015 - 08/31/2016 Scott Michael Wilhelm, MD FACS Secretary|06/01/2015 - 08/31/2016 Jennifer Starkey Executive Director|01/03/2011 - 01/03/2050 Brian Joseph Santin, MD FACS RAS Representative|10/10/2013 - 10/01/2016 Bruce Jeffrey Averbook, MD FACS Governor|10/29/2014 - 10/25/2017 Michael Stephen Benninger, MD FACS Specialty Society Governor|10/29/2014 - 10/25/2017 Larry James Copeland, MD FACS Specialty Society Governor|10/28/2011 - 10/25/2017 Joann Marie Lohr, MD FACS Specialty Society Governor|10/28/2011 - 10/25/2017 Christopher R. McHenry, MD FACS Governor|10/16/2009 - 10/08/2015 Timothy A. Pritts, MD FACS Specialty Society Governor|10/29/2014 - 10/25/2017 Michael Duke Sarap, MD FACS Governor|10/08/2010 - 10/31/2016 Steven M. Steinberg, MD FACS Governor|10/05/2012 - 10/08/2015 Randy Joseph Woods, MD FACS Governor|10/10/2013 - 10/31/2016 Charles Joseph Yowler, MD FACS Governor|10/05/2012 - 10/08/2015 Jeffrey A. Claridge, MD FACS COT State Provincial Chair|07/20/2015 - 07/20/2021 Michael Duke Sarap, MD FACS CoC State Chair|07/01/2014 - 07/01/2017 Show More


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Originally posted on Pro Sports Daily | Last updated 1/29/13
LOS ANGELES, CA - JANUARY 19: Portrait of Evgeni Nabokov #20 of the San Jose Sharks before the game bewteen the Los Angeles Kings at Staples Center on January 19, 2010 in Los Angeles, California. (Photo by Harry How/Getty Images)
PITTSBURGH -- Jack Capuano knew what his New York Islanders were up against. The coach watched his team blow two-goal leads in each of their previous two games. Furthermore, they were playing in a city where their visits have been almost always fruitless in recent years. Yet the Islanders got a rare win in Pittsburgh on Tuesday night, and there was no doubt about the identity of the better team. New York rode Evgeni Nabokov's 37 saves and goals from four different players to a 4-1 victory over the Penguins at Consol Energy Center. "I don't think too many would have given us a chance in this one," Capuano said. Probably not. The Penguins had won 14 of their previous 15 home games against the Islanders. However, Matt Moulson had a goal and an assist for the Islanders, and Casey Cizikas, Michael Grabner and John Taveras also scored for the Islanders (3-2-1). Frans Nielsen had two assists. Nabokov came within 1:09 of the 52nd shutout of his 12-year career before Pascal Dupui...
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Most Popular "U.s. Pacific Fleet" Titles
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1. Pearl Harbor (2001)
PG-13 | 183 min | Action, Drama, Romance
Pearl Harbor follows the story of two best friends, Rafe and Danny, and their love lives as they go off to join the war.
Writer: Randall Wallace | Director: Michael Bay | Stars: Ben Affleck, Kate Beckinsale, Josh Hartnett, William Lee Scott
Votes: 236,596
2. Tora! Tora! Tora! (1970)
G | 144 min | Drama, History, War
A dramatization of the Japanese attack on Pearl Harbor and the series of American blunders that allowed it to happen.
Writers: Larry Forrester, Hideo Oguni, Ryûzô Kikushima, Gordon W. Prange, Ladislas Farago | Directors: Richard Fleischer, Kinji Fukasaku, Toshio Masuda | Stars: Martin Balsam, Sô Yamamura, Jason Robards, Joseph Cotten
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As he is retiring, Jonathon Scott reminisces about his long Navy career and the development of the role of the aircraft carrier from the early 20s.
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A countergirl at a San Diego soda shop has a lot of sailor "boyfriends," but her heart really belongs to a free-spirited gunner, who doesn't want to be tied down to any one woman.
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- Detail Images
Jump headfirst into alpine and backcountry adventures.
Whether you're ice climbing, peak bagging, or skinning out to your favorite backcountry bowl, the Men's Mammut Base Jump Touring Pant has your lower half appropriately covered. The quick-drying Schoeller FTC shell fabric repels water and wicks moisture away to where it can evaporate, leaving you warm and dry. The fabric's stretch properties combine with the pre-shaped knees and regular fit to allow the full range of motion necessary for your alpine adventures.
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I gave this as a gift to my brother who is pushing 6'5 and an avid skier. He has told me he loves how comfortable these are, how the length is great for him and above all the stretch of the pant. He beats the hell out of his gear and so far this has been a killer pant and held up great for him! Can't go wrong with Mammut products.
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COLDBACK treatment?
I have looked at...
COLDBACK treatment?
I have looked at Mammot and othersoft shell pants for bckcountry ski-touring. I am having trouble finding pants that fit. They seem to be all designed or very tall people and most all seem to be black which in all my past experience absorbs alot of heat especiaaly in sunny dry area like here in CO at 12000ft. My waist of pants in us34 and inseam is 29. How does the black not absorb absorb heat and warrant not to do so?


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People are always saying that time speeds up as you get older. I'm not sure I believe it 100%, but I can believe that all the things I do monthly (write these posts, for instance) do seem to come far more often than would be predicted by the word "monthly". We're living a busy life. It's exciting, but it moves quickly. April came and went, then May. Now it's June. We'll blink and another wedding season will have come and gone. In the meantime, we press on and take things as one-day-at-a-time as possible.
May was a bit of a rough month for me. I sprained my ankle halfway through and I've had to rest it since. Even though it was a minor sprain (as self-diagnosed by me and the internet), it's still swollen more than two weeks later. If you know anything about me, you know I walk a lot. It's my main form of entertainment and my default activity to get out of the house and do something. (It's a working from home thing, see. If I didn't get out and deliberately walk, I'd just sit inside my house all day at the computer.)


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This Facebook App Will Pick Out The 10 Best Friends You Would Take To The Super Bowl
The Visa You+10 Draft helps you pick out your 10 BFFs based on your social media interactions.
The "You+10 Draft" is an interactive app created by credit company Visa that can determine your 10 closest friends on Facebook. The football-themed app analyzes your recent Facebook interactions and 'drafts' a list of the 10 best friends that you would want to take to the Super Bowl. Then, it creates a personalized video featuring the 10 friends with roles like 'No. 1 fan', 'commentator' and 'VIP.'
The campaign is working tobpromote Visa's contest in partnership with the NFL, where one lucky cardholder will get the chance to attend Super Bowl XLVI in Indianapolis on 5 February with 10 other friends. The Facebook app was developed by global ad agency AKQA.
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PSFK Labs Presents
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The New Consumer and Their Journey to Effectiveness, Balance & Personal Growth


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Best of News
Prosecutor Eugenio Fusco speaks during the trial to Giuseppe Orsi... News PhotoAerospace Industry,Courtroom,Former,Horizontal,Italy,Law,Legal Defense,Legal Trial,Prosecutor,Talking,VaresePhotographer AFPCollection: AFP 2013 AFPProsecutor Eugenio Fusco speaks during the trial to Giuseppe Orsi former head of the Italian aerospace and defense giant Finmeccanica on June 19, 2013 at the courtroom in Busto Arsizio near Varese. The former head of Finmeccanica goes on trial in a case involving alleged bribes to win a 560 Mio euro helicopter contract in India. AFP PHOTO / GIUSEPPE CACACE (Photo credit should read GIUSEPPE CACACE/AFP/Getty Images)


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Archive for the 'Keyboards' Category
Cherry MX 6.0 Keyboard Review0 CommentsPosted by Jon Martindale on August 12, 2015 under Highlights 2, KeyboardsCherry is a name that should be familiar to any PC user. It makes the MX switches which have shown up in just about every gamer and typist's high-end keyboard over the past decade. Today we look at ... more.
Corsair Gaming STRAFE mechanical keyboard review1 CommentsPosted by Jon Martindale on August 10, 2015 under Highlights, KeyboardsCorsair Gaming dismayed long-time fans last year when it dropped its famous sales logo in favour of a tribal tattoo. Following fan outrage however, it ... more.
Microsoft Xbox One set to get mouse and keyboard support9 CommentsPosted by Anton Shilov on July 22, 2015 under Console, Keyboards, Mouse, Peripheral, Software & GamingIt is not a secret that Microsoft Corp.'s Xbox One game console will get its own version of Windows 10 operating system, but it is not completely clear what that OS will support and what it will not... more.
Logitech introduces new name 'Logi', because 'tech' is everywhere2 CommentsPosted by Anton Shilov on July 9, 2015 under Accessories, Camera, Headphones, Keyboards, Mouse, Peripheral, SpeakersLogitech on Wednesday announced that many of its new products will carry "Logi" brand from now on to reflect that they are more than technology and are a part of modern lifestyle. Initially, the �... more.
Ozone Strike Battle keyboard review3 CommentsPosted by Jon Martindale on June 28, 2015 under Highlights, KeyboardsPC gamers come in all shapes and sizes and so do the spaces they game on. If you have a small room with limited desk space are you stuck with an oversiz... more.
Tesoro Lobera Spectrum Keyboard Review1 CommentsPosted by Matthew Wilson on June 15, 2015 under Highlights V, KeyboardsTesoro has been releasing so many RGB keyboards since the tail end of last year that it is hard to keep up. Today we are going to be looking at the Lobera Spectrum, which takes a different approach co... more.
Exclusive Aerocool interview with Tom Naughton from AOne0 CommentsPosted by Andrzej on June 12, 2015 under Cases, Headphones, Interviews, Keyboards, MouseWithout doubt, Aerocool has been one of the better success stories over the past few years. From being a company best known for entry level 'piano black finish' cases and front panels for controlling... more.
Huge range of Aerocool gaming peripherals ready for launch0 CommentsPosted by Andrzej on June 11, 2015 under Computex, Headphones, Keyboards, MouseThe Computex trade show spans multiple locations in Taipei. Most of the main brands will occupy the huge, purpose built Nangang centre, while others take space in 101 or the Hyatt hotel. Local compani... more.
KGTV: Corsair Strafe Mechanical Gaming Keyboard2 CommentsPosted by Allan 'Zardon' Campbell on June 9, 2015 under KeyboardsCorsair have earned a strong reputation in the industry for creating some cutting edge mechanical gaming keyboards and their latest model the Strafe is due for release very soon. Our man Leo Waldock... more.
i-rocks Golem Series K50E gaming keyboard1 CommentsPosted by Jon Martindale on May 22, 2015 under KeyboardsAlthough we do love a good mechanical keyboard here at KitGuru, we're not blind to the fact that it is not the only way to do things. There are of cours... more.
Roccat Ryos TKL Pro Review4 CommentsPosted by Jon Martindale on May 11, 2015 under Highlights, KeyboardsDo you ever find yourself wondering why the modern keyboard design has not changed much in recent years? Who uses a CAPSLOCK key any more? And do we really need a numpad? While certain functions might... more.
Cherry debuts new MX switch keyboard at Gadget Show Live2 CommentsPosted by Jon Martindale on April 8, 2015 under Event, KeyboardsCherry is a company you all know as the maker of the universally popular MX keyboard switches. Whether you're a fan of brown, black, red, blue or any of the other coloured variants, chances are if you... more.
Inside Chroma at i54 with Nick Haywood from Razer0 CommentsPosted by Andrzej on April 6, 2015 under Event, KeyboardsIn the huge exhibitor hall at Multiplay's i54 event at the Ricoh Arena, it was hard to miss the Razer battle bus. This black and green branded double decker travels Europe, full to the brim with DinoP... more.
Cooler Master showcase Octane products on KitGuru TV0 CommentsPosted by Andrzej on April 4, 2015 under Keyboards, MouseWhen a key feature of a product is visual, it's hard to convey that in written form - which is where KitGuru TV comes in. We invited Chris Gough from Cooler Master into the studio to take us through s... more.
Cooler Master Octane M35 and MB7C review3 CommentsPosted by Jon Martindale on April 4, 2015 under Keyboards, MouseBeing a gamer is not necessarily cheap. If you want to do it on a console, it is going to cost you a few hundred on the latest system and then at least anothe... more.
Steelseries Apex M800 mechanical keyboard0 CommentsPosted by Jon Martindale on March 30, 2015 under Highlights, KeyboardsEven though most serious gamers use mechanical keyboards these days, many do not realise that the technology behind those key-switches is over 30 years... more.
Original designer gives ZX Spectrum keyboard approval6 CommentsPosted by Jon Martindale on March 5, 2015 under Keyboards, Mobile, PCBefore I and I'm sure many of you, were tapping away at keyboards and gaming away on CRT screens with roller ball mice, people like our fearless leader Zardon had a different take on computing altoget... more.
Cougar 200K gaming keyboard review5 CommentsPosted by Jon Martindale on February 24, 2015 under Highlights 2, KeyboardsMechanical switches are not the only option available for the enthusiast user. Along with the traditional membrane keyboard that everyone graduates from at some point, there is the middle ground. The ... more.
Tesoro Excalibur RGB Mechanical Keyboard Review0 CommentsPosted by Matthew Wilson on February 22, 2015 under Highlights, KeyboardsWe continue to make our way through the growing list of 'RGB' peripherals today with a look at the Tesoro Excalibur RGB Edition Mechanical Keyboard. While other RGB keyboards will set you back upwards... more.
Cougar 700K Mechanical Gaming Keyboard Review0 CommentsPosted by Henry Butt on January 29, 2015 under Highlights 2, KeyboardsToday we are going to take a look at one of the latest mechanical gaming keyboards from Cougar, the 700K. This model boasts an impressive specification which includes Cherry mechanical switches, LED... more.
ASUS STRIX Tactic Pro gaming keyboard review0 CommentsPosted by Jon Martindale on December 19, 2014 under Highlights, KeyboardsGetting yourself the right gaming keyboard can be a very personal experience. Chances are you want mechanical, even if you have not used one before. Switch choice is important, backlighting too - and ... more.
Cougar wants to change the image of membrane keyboards9 CommentsPosted by Jon Martindale on December 11, 2014 under KeyboardsIn the past half decade or so, the world and his gaming dog have decided for the most part, that mechanical keyboards are great and that membrane boards just aren't up to scratch. It's a difficult thi... more.
Tesoro Durandal G1NL Mechanical Gaming Keyboard Review0 CommentsPosted by Henry Butt on December 4, 2014 under Highlights V, KeyboardsToday we are going to look at a mechanical gaming keyboard from a company called Tesoro, the Durandal G1NL. Tesoro are looking to compete with the more established players in the market such as Cor... more.
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Ozone Strike Pro Cherry MX Red USB keyboard review1 CommentsPosted by Matthew Wilson on September 29, 2014 under KeyboardsTechnology is constantly evolving but some things never change. Mechanical keyboards have been with us for so long now and yet, they are still largely considered to be the pinnacle of PC input soluti... more.
Logitech launches new keyboard with its own mechanical switches8 CommentsPosted by Jon Martindale on September 17, 2014 under KeyboardsLogitech today announced the upcoming release of a brand new keyboard, called the G910 Orion Spark, featuring its own brand of mechanical switches which it claims actuate up to 25 per cent faster than... more.
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Gamdias Hermes gaming keyboard review1 CommentsPosted by Bob Crane on June 27, 2014 under KeyboardsIf you are in the market for a new gaming keyboard then there are no shortage of products available from companies such as Razer, Steelseries, Roccat and TTeSports. Today we are seeing how new kid on ... more.
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JDM Allstars DONINGTON ALPINE Round 2, 2010 from Josh Allen on Vimeo.
I'm currently sitting here preparing to leave for Round 3 of JDM Allstars, but I thought I would just post something that landed in my inbox before I head off. Josh Allen's been working non stop to get this video from Round 2 up before this weekends event. In the time he's had to make it, he's done an incredible job. I've got to say, this is probably the best drifting video I've seen in a long, long time. The variety of action shots and exciting angles, mixed in with fun lifestyle footage and brilliant editing… those other bigtime drifting videographers had better watch out for Josh Allen!
Stay tuned for more JDM Allstars coverage on MotorMavens very soon!
::Daniel BridleTweet


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File this under total rumor, but we're intrigued. Michelle Villett, the founder and editor of beautyeditor.ca dug up some old photos of
the most beautiful man in the world Ryan Gosling and thinks perhaps his nose wasn't always as perfect as the rest of him. Is this possible? Let's take a closer look, shall we.


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By Kyoboku
Open iTunes to buy and download apps.
The Daruma! app is here to help you achieve your goals. A wish you've had for a while but doesn't seem to happen for you. You need a motivator. Get Daruma! to help! Read more about Daruma at our website.
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Compatibility: Requires iOS 3.1 or later. Compatible with iPhone, iPad, and iPod touch.


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Greenpeace report on genetic testing of tinned tuna from around the world, showing how tuna is being mixed following the unsustainable use of fish aggregation devices.
New evidence to show the urgent need for marine reserves in the Pacific, as part of a global network of protection, was today presented by Greenpeace to the officials who can make or break the future of tuna in the Pacific.
1 - 2 of 2 results.


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Low Carb Soup Recipes
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Here's a fantastic first course for guests. Rich, creamy and cheesy, it will warm you from the inside out and stir your appetite for what's to come.—Charlotte Rogers, Virginia Beach, VirginiaView Golden Gouda Mushroom Soup Recipe


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4.89 out of 5 stars
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Very helpful and friendly and would reccomend ya'll to someone else. think they need a raise! (kisha and Aaron)
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Excellent selection and price on cars. Took great care in working with me since I was located 70 miles away.
Had a problem with the Matte Black stripes on the car which I thought were just dirty water that had dried on them. Only when I washed the car did I notice that the stripes had wax on them. Called my sales person and he said to bring the car down and they would see what needed to be done. No Problem.
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So I accidentally texted my ex the night of St.Patrick's Day and we started talking. This is the first time for probably a month. We broke up in November but it was very back and forth for a while. Anyway he started saying things like he thinks about me more than he should and that he effed things... Show More
Most Helpful Guy
He replied like that because he was embarrassed about the previous night. Especially the way you said he was drunk and frisky - he knew he wasn't very drunk, and he probably does still like you. But you made him embarrassed so he tried to just use short replies to still tell you how he felt - he said maybe he was a little frisky, which means he was trying to tell you he was serious about what he said last night. In my opinion he's not a jerk; he's just embarrassed, especially because of the way you confronted him about it, making it seem like you're assuming what he said wasn't from the heart. Hope this helped, and good luck :)
Even though he's probably not a jerk, there's always a reason for a breakup, so it's probably better just to try to forget him.
Okay thank you for your answer!
No problem :)


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Re: this summer ce juillet ci
I plan on visiting Ouagadougu close to that timeframe. Might i ask the reason you are going to the country? If interested we might be able to to help the same cause.
You can call me Pat.
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Vim's available everywhere. But when you're on a strange box, with none of your favourite plugins installed, how do you find your way around? Let's look at Vim's built-in tools...
Kris Jenkins is a freelance developer. Or a retired startup-hacker. Nobody is quite certain which.
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