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Publications (147)634.86 Total impact
Article: Klotho-related Molecules Upregulated by Smoking Habit in Apparently Healthy Men: A Cross-sectional Study[Show abstract] [Hide abstract]
ABSTRACT: While aging is unavoidable, the aging mechanism is still unclear because of its complexity. Smoking causes premature death and is considered as an environmental aging accelerator. In the present study, we focused on the influence of smoking to the serum concentration of anti-aging protein α-klotho (αKl) and the β-klotho-associated protein fibroblast growth factor (FGF)-21 in men. Subjects consisted of apparently healthy men over 40 years of age who underwent health examination. Physical and biochemical parameters, including the levels of several cytokines and growth factors, were obtained from the subjects. Among middle-aged men (46.1 ± 5.1 years), serum levels of FGF-21, soluble αKl (sαKl), and inflammation-related cytokine interleukin (IL)-6 were significantly higher in smokers than in never-smokers. Serum levels of FGF-21 increased and correlated with alanine transaminase, γ guanosine-5'-triphosphate, and total cholesterol only in smokers, suggesting FGF-21 as a metabolic disorder-related factor in smokers. In aged men (60.3 ± 1.7 years), although the serum levels of sαKl in never-smokers were low, smokers showed highly increased serum levels of sαKl. Serum levels of sαKl was correlated with IL-6 in middle-aged never-smokers, suggesting sαKl regulates IL-6. However, this correlation was disrupted in smokers and aged men.Scientific Reports 09/2015; 5:14230. DOI:10.1038/srep14230 · 5.58 Impact Factor
Article: Myocardial Energy Provision Is Preserved by Increased Utilization of Glucose and Ketone Bodies in CD36 Knockout Mice[Show abstract] [Hide abstract]
ABSTRACT: CD36 is an important transporter of long-chain fatty acids (LCFAs) in the myocardium. As we have reported previously, CD36-deficient patients demonstrate a marked reduction in myocardial uptake of (123)I-15-(p-iodophenyl)-(R, S)-methyl pentadecanoic acid (BMIPP), which is an analog of LCFAs, while myocardial (18)F-fluorodeoxy-glucose (FDG) uptake is increased. However, it has not been clarified whether energy provision is preserved in patients with CD36 deficiency. The aims of the current study were to investigate the myocardial uptake of glucose and alterations in myocardial metabolites in wild-type (WT) and CD36 knockout (KO) mice. High-resolution positron emission tomography (PET) demonstrated markedly enhanced glucose uptake in KO mouse hearts compared with those of WT mice in real-time. The myocardial protein expression of glucose transporter protein 1 (GLUT1) was significantly enhanced in KO mice compared to WT mice, whereas that of GLUT4 was not altered. While the myocardial expression of genes involved in fatty acid metabolism did not increase in KO mice, that of genes related to glucose utilization compensatorily increased in KO mice. The metabolomic analysis of cardiac tissues revealed that the myocardial concentrations of ATP and phosphocreatine were maintained, even in KO mice. The concentration of 3-hydroxybutyric acid and mRNA expression of hydroxybutyrate dehydrogenase in the heart were significantly higher in KO than in WT mice. These data suggest that high-energy phosphate might be preserved by the increased utilization of glucose and ketone bodies in CD36KO mouse hearts under conditions of deficient LCFA uptake. Copyright © 2015. Published by Elsevier Inc.Metabolism 06/2015; 64(9). DOI:10.1016/j.metabol.2015.05.017 · 3.89 Impact Factor
Article: Temporal Expression of Growth Factors Triggered by Epiregulin Regulates Inflammation Development[Show abstract] [Hide abstract]
ABSTRACT: In this study, we investigated the relationship between several growth factors and inflammation development. Serum concentrations of epiregulin, amphiregulin, betacellulin, TGF-α, fibroblast growth factor 2, placental growth factor (PLGF), and tenascin C were increased in rheumatoid arthritis patients. Furthermore, local blockades of these growth factors suppressed the development of cytokine-induced arthritis in mice by inhibiting chemokine and IL-6 expressions. We found that epiregulin expression was early and followed by the induction of other growth factors at different sites of the joints. The same growth factors then regulated the expression of epiregulin at later time points of the arthritis. These growth factors were increased in patients suffering from multiple sclerosis (MS) and also played a role in the development of an MS model, experimental autoimmune encephalomyelitis. The results suggest that the temporal expression of growth factors is involved in the inflammation development seen in several diseases, including rheumatoid arthritis and MS. Therefore, various growth factor pathways might be good therapeutic targets for various inflammatory diseases. Copyright © 2015 by The American Association of Immunologists, Inc.The Journal of Immunology 01/2015; 194(3):1039-46. DOI:10.4049/jimmunol.1400562 · 4.92 Impact Factor
- Atherosclerosis 08/2014; 235(2):e104-e105. DOI:10.1016/j.atherosclerosis.2014.05.281 · 3.99 Impact Factor
Article: A novel potent and selective pparalpha agonist, k-877, ameriolates both fasting and postprandial hypertriglyceridemiaAtherosclerosis 08/2014; 235(2):e169-e170. DOI:10.1016/j.atherosclerosis.2014.05.490 · 3.99 Impact Factor
Article: Gender differences in the relationship between blood pressure and body mass index during adolescence[Show abstract] [Hide abstract]
ABSTRACT: Objective In adults, gender and obesity play significant roles in the regulation of blood pressure (BP). This study investigated the effects of gender and body mass index (BMI) on BP during adolescence. Design and setting A cross-sectional and longitudinal study involving 6838 students under twenty years old (median, eighteen years old; male, 4624; female, 2214) at Osaka University visited the Healthcare Center for their matriculation health examination from April to May in the years 2008, 2009, and 2010, and re-visited the Healthcare Center for their student health examination from May to June in the years 2011, 2012, and 2013. Methods Height, body weight, and BP were measured in students both on and 3 years after admission to Osaka University. Results On admission, the slope of the regression line for BMI and systolic BP (SBP) in non-underweight students was significantly different between genders. SBP and diastolic BP (DBP) increased in both genders during the observation period. Among male students who had a normal BMI on admission, those who had an increase in BMI of over 4% during the observation period showed a greater increase in SBP than those who had a change in BMI of −4% to 4%. On the other hand, female students showed no change in BP with the increase in BMI. Conclusions The magnitude of BP elevation with increased BMI was associated with gender during adolescence. This may be a cause of the higher prevalence of hypertension in adult males.Obesity Research & Clinical Practice 07/2014; 9(2). DOI:10.1016/j.orcp.2014.07.001 · 1.18 Impact Factor
Conference Paper: WIDESPREAD CORONARY ENDOTHELIAL DYSFUNCTION IN THE ABSENCE OF HDL RECEPTOR SRB1 IN A MOUSE MODEL OF ISCHEMIC CARDIOMYOPATHY35th Annual Scientific Meeting of the; 06/2014
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ABSTRACT: Background: Smoking and metabolic syndrome (MetS) are major public health problems in modern society and are important risk factors of cardiovascular disease (CVD). The association of smoking, MetS, and CVD is widely reported, but reports targeted to women are few. In the present study, we evaluated risk factors, including visceral fat area (VFA), for CVD and development of subclinical atherosclerosis in female smokers especially. Methods and results: Subjects consisted of 162 apparent healthy female and male smokers, and 315 age-matched never-smokers who underwent a health examination in the Osaka University Health Care Center. For female smokers, lifestyle and carotid intima-media thickness (IMT) were evaluated. Triglycerides were significantly higher and high-density lipoprotein-cholesterol significantly lower in smokers than in never-smokers for both men and women. However, VFA was significantly high only in smoking women when compared with never-smokers. Multivariate analysis revealed that age, body mass index, and smoking were the independent predictors of high VFA in women. In addition, annual IMT increase was significantly higher in smokers than never-smokers in women. Conclusions: VFA was notably high in female smokers, but the difference was not observed in men. Smoking habit is an important risk factor of visceral fat accumulation and progression of subclinical atherosclerosis in women.Circulation Journal 03/2014; 78(5). DOI:10.1253/circj.CJ-13-1134 · 3.94 Impact Factor
Article: Reference Interval for the Apolipoprotein B-48 Concentration in Healthy Japanese Individuals.[Show abstract] [Hide abstract]
ABSTRACT: Aim: Small intestine-derived chylomicrons and chylomicron remnants, which are predominant in patients with postprandial hypertriglyceridemia, chylomicron syndrome and/or familial dyslipidemia, carry one molecule of apolipoprotein B-48(apo B-48) per lipoprotein particle. We investigated the reference interval for the apo B-48 concentration. Methods: We studied 516 individuals who provided written informed consent and confirmed that they were not taking any medications. BMI, waist circumference, blood pressure and the fasting serum concentrations of LDL-C, triglyceride(TG), HDL-C and apo B-48 were measured. The Apo B-48 concentrations were compared according to sex, a pre- or postmenopausal status, dyslipidemia(LDL-C ≥140 mg/dL, TG ≥150 mg/dL, HDL-C <40 mg/dL), metabolic syndrome(MetS) and the number of risk factors. Results: The fasting apo B-48 concentrations(mean±SD) were significantly higher in men than in women(3.8±3.3 μg/mL vs 2.4±1.9 μg/mL, p<0.001), subjects with a BMI of ≥25 kg/m(2) versus a BMI of <25 kg/m(2) (4.4±3.7 μg/mL vs 2.8±2.4 μg/mL, p<0.001) and those with versus without MetS(6.5±4.3 μg/mL vs 3.0±2.6 μg/mL, p<0.001). High apo B-48 concentrations were also observed in correlation with the number of risk factors for the MetS. The upper reference limit of apo B-48 was estimated to be 5.7 μg/mL among the 332 patients with normolipidemia, excluding those exhibiting a mean value above ±2.58 standard deviations(SDs), as the mean and range of mean ±1.96 SD were calculated to be 2.04 μg/mL(reference value) and 0.74 to 5.65 μg/mL(reference interval), respectively. Conclusions: Based on our study of normolipidemic patients, the upper reference limit for the fasting apo B-48 concentration is estimated to be 5.7 μg/mL.Journal of atherosclerosis and thrombosis 02/2014; 21(6). DOI:10.5551/jat.22558 · 2.73 Impact Factor
Article: Is Low Testosterone Concentration a Risk Factor for Metabolic Syndrome in Healthy Middle-aged Men?[Show abstract] [Hide abstract]
ABSTRACT: To clarify the probability of low serum testosterone level as a risk factor for metabolic syndrome (MS) in middle-aged men, we measured serum total testosterone (TT) and assessed several metabolic factors because the direct risk for MS has not been investigated fully in men. This study comprised 1150 men aged ≥30 years. Physical and laboratory variables were assessed. Analyses were conducted to determine the association between serum TT level and incidence risk of MS and MS factors by a separate logistic regression model. Mean (± standard deviation [SD]) serum TT level was 5.4 ± 1.7 ng/mL in the 1150 men, and only 92 men (8.0%) were classified as having MS by the Japanese criteria. In age-adjusted analyses, higher levels of serum TT were independently associated with a lower risk of MS (odds ratio, per SD decrement of TT, 2.3; 95% confidence interval [CI], 1.7-2.9). MS risk increased by lower quintile of TT: ORs were 15.1 (95% CI, 4.6-50.0) for first quintile, 8.8 (95% CI, 2.6-29.9) for second quintile, 5.8 (95% CI, 1.7-20.5) for third quintile, and 5.0 (95% CI, 1.4-17.9) for fourth quintile compared with highest quintile of TT. Age-adjusted ORs for the incidence of dichotomous components of MS per SD decrement of TT were 1.8 (95% CI, 1.5-2.3) for waist circumference, 1.6 (95% CI, 1.1-2.2) for dyslipidemia, and 1.5 (95% CI, 1.2-1.8) for hypertension. We found that higher probability of MS was associated with lower levels of serum TT level in relatively healthy middle-aged Japanese men.Urology 10/2013; 82(4):814-9. DOI:10.1016/j.urology.2013.06.023 · 2.19 Impact Factor
Article: Correction: Establishment of a Novel Murine Model of Ischemic Cardiomyopathy with Multiple Diffuse Coronary Lesions[Show abstract] [Hide abstract]
ABSTRACT: [This corrects the article on p. e70755 in vol. 8.].PLoS ONE 08/2013; 8(8). DOI:10.1371/annotation/8d40f661-efc4-4590-8922-b3a6f5374e12 · 3.23 Impact Factor
Article: Establishment of a Novel Murine Model of Ischemic Cardiomyopathy with Multiple Diffuse Coronary Lesions[Show abstract] [Hide abstract]
ABSTRACT: Atherosclerotic lesions of the coronary arteries are the pathological basis for myocardial infarction and ischemic cardiomyopathy. Progression of heart failure after myocardial infarction is associated with cardiac remodeling, which has been studied by means of coronary ligation in mice. However, this ligation model requires excellent techniques. Recently, a new murine model, HypoE mouse was reported to exhibit atherogenic Paigen diet-induced coronary atherosclerosis and myocardial infarction; however, the HypoE mice died too early to make possible investigation of cardiac remodeling. Therefore, we aimed to modify the HypoE mouse model to establish a novel model for ischemic cardiomyopathy caused by atherosclerotic lesions, which the ligation model does not exhibit. In our study, the sustained Paigen diet for the HypoE mice was shortened to 7 or 10 days, allowing the mice to survive longer. The 7-day Paigen diet intervention starting when the mice were 8 weeks old was adequate to permit the mice to survive myocardial infarction. Our murine model, called the "modified HypoE mouse", was maintained until 8 weeks, with a median survival period of 36 days, after the dietary intervention (male, n = 222). Echocardiography demonstrated that the fractional shortening 2 weeks after the Paigen diet (n = 14) significantly decreased compared with that just before the Paigen diet (n = 6) (31.4±11.9% vs. 54.4±2.6%, respectively, P<0.01). Coronary angiography revealed multiple diffuse lesions. Cardiac remodeling and fibrosis were identified by serial analyses of cardiac morphological features and mRNA expression levels in tissue factors such as MMP-2, MMP-9, TIMP-1, collagen-1, and TGF-β. Modified HypoE mice are a suitable model for ischemic cardiomyopathy with multiple diffuse lesions and may be considered as a novel and convenient model for investigations of cardiac remodeling on a highly atherogenic background.PLoS ONE 08/2013; 8(8):e70755. DOI:10.1371/journal.pone.0070755 · 3.23 Impact Factor
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ABSTRACT: Progranulin (PGRN) is a multifunctional protein known to be involved in inflammation. However, the relation between PGRN and atherosclerosis remains elusive. The aim of this study was to define the role of PGRN in the development of atherosclerosis.Methods and ResultsFirst, we checked the expression levels of PGRN in human atherosclerotic plaques. Immunohistochemical analysis showed that PGRN is strongly expressed in foam cells of atherosclerotic plaques. We also found that PGRN is expressed more abundantly in macrophages than in the smooth muscle cells of atherosclerotic lesions in ApoE(-/-) mice fed a high-fat diet for 12 weeks. Next, PGRN(-/-)ApoE(-/-) mice were generated to investigate the effect of PGRN on the development of atherosclerosis. PGRN(-/-)ApoE(-/-) mice exhibited severe atherosclerotic lesions compared to PGRN(+/+)ApoE(-/-) mice, despite their anti-atherogenic lipid profile. These results are partly due to enhanced expression of inflammatory cytokines, adhesion molecules, and decreased expression of endothelial nitric oxide synthase. In addition, lack of PGRN leads to accumulate excessive cholesterol in the macrophages and alter HDL-associated proteins. PGRN seems to be involved in the pathogenesis of atherosclerosis, possibly by various anti-atherogenic effects, including modulation of local and/or systemic inflammation.Cardiovascular Research 07/2013; 100(1). DOI:10.1093/cvr/cvt178 · 5.94 Impact Factor
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ABSTRACT: The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Imflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from animal models have shown that the amplifier is activated by stimulation of NFκB and STAT3 and induces chemokines and inflammation via an NFκB loop. However, its role in human diseases is unclear. Here, we combined two genome-wide mouse screens with SNP-based disease association studies, revealing 1,700 genes related to the IL-6 amplifier, 202 of which showed 492 indications of association with ailments beyond autoimmune diseases. We followed up on ErbB1 from our list. Blocking ErbB1 signaling suppressed the IL-6 amplifier, whereas the expression of epiregulin, an ErbB1 ligand, was higher in patients with inflammatory diseases. These results indicate that the IL-6 amplifier is indeed associated with human diseases and disorders and that the identified genes may make for potential therapeutic targets.Cell Reports 02/2013; 3(5). DOI:10.1016/j.celrep.2013.01.028 · 8.36 Impact Factor
Article: Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity (Reprinted from BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol 257, pg 79-83, 1999)[Show abstract] [Hide abstract]
ABSTRACT: We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K, et al., Biochem. Biophys. Res. Commun. 221, 286-289, 1996). The apM1 gene product was a kind of soluble matrix protein, which we named adiponectin. To quantitate the plasma adiponectin concentration, we have produced monoclonal and polyclonal antibodies for human adiponectin and developed an enzyme-linked immunosorbent assay (ELISA) system. Adiponectin was abundantly present in the plasma of healthy volunteers in the range from 1.9 to 17.0 mg/ml. Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adiponectin is secreted only from adipose tissue. The ELISA system developed in this study will be useful for elucidating the physiological and pathophysiological role of adiponectin in humans. (C) 1999 Academic PressBiochemical and Biophysical Research Communications 08/2012; 425(3):560-564. · 2.30 Impact Factor
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ABSTRACT: We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K., et al.,Biochem. Biophys. Res. Commun.221, 286–289, 1996). The apM1 gene product was a kind of soluble matrix protein, which we named adiponectin. To quantitate the plasma adiponectin concentration, we have produced monoclonal and polyclonal antibodies for human adiponectin and developed an enzyme-linked immunosorbent assay (ELISA) system. Adiponectin was abundantly present in the plasma of healthy volunteers in the range from 1.9 to 17.0 mg/ml. Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adiponectin is secreted only from adipose tissue. The ELISA system developed in this study will be useful for elucidating the physiological and pathophysiological role of adiponectin in humans.Biochemical and Biophysical Research Communications 08/2012; 425(3):560-4. DOI:10.1016/j.bbrc.2012.08.024 · 2.30 Impact Factor
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ABSTRACT: Background: Smoking is a major risk factor for cardiovascular disease. Also, inflammatory activation and metabolic disorder are the mediators of smoking-induced atherosclerotic progression. The aim of the present study was to investigate whether current smoking and smoking cessation alter inflammatory or metabolic status and affect subclinical atherosclerosis in apparently healthy men. Methods and results: Classical risk factors and smoking habit were evaluated in 354 men who completed health examinations annually without any current medications. Carotid intima-media thickness (IMT) was followed for 27.1±4.5 months. At baseline, both maximum and mean IMT significantly changed during 2-year follow-up. They tended to increase along with progression of smoking habit, with significantly greater maximum IMT in current smokers compared with never smokers. Both maximum and mean IMT significantly changed during 2-year follow-up, and tended to increase with progression of smoking habit, with maximum IMT being greatest for current smokers. Past smokers tended to have greater IMT increase than never smokers. Among smoking habit and some atherosclerotic risk markers that showed significant correlation with maximum IMT increase, stepwise regression showed that smoking habit and serum low-density lipoprotein-cholesterol (LDL-C) level were the only independent predictors. Conclusions: Significant 2-year progression of subclinical atherosclerosis was associated with continuous smoking and LDL-C. This was only partly moderated in past smokers despite complete reversal of inflammatory activation, suggesting another crucial factor for inhibiting accelerated progression of subclinical atherosclerosis in men.Circulation Journal 08/2012; 76(12). DOI:10.1253/circj.CJ-11-1506 · 3.94 Impact Factor
Article: Apolipoprotein B-48 to Triglyceride Ratio Is a Novel and Useful Marker for Detection of Type III Hyperlipidemia after Antihyperlipidemic Intervention.[Show abstract] [Hide abstract]
ABSTRACT: Aim: Remnant lipoproteins are atherogenic and are accumulated in patients with type III hyperlipidemia (HL). Although type III HL is diagnosed by phenotyping apolipoprotein (apo) E, this procedure is time-consuming and inconvenient for routine clinical use. Clinical indices for screening type III HL in untreated HL patients have been proposed; however, in clinical settings, HL patients are promptly treated with lipid-lowering agents without diagnosing the underlying cause. We investigated whether existing clinical indices for screening type III HL as well as the apo B-48/triglyceride (TG) ratio, which was suggested to be related to the accumulation of small chylomicron (CM) remnants, are useful after the initiation of lipid-lowering therapies. Methods: In 25 normolipidemic subjects and 191 treated HL patients (type I, n =6; IIa, 62; IIb, 66; III, 12; IV, 22; and V, 23) from Osaka University Hospital and related hospitals, fasting low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG, and apolipoproteins were measured and clinical indices were evaluated statistically. Results: Apo B-48 levels were significantly higher in patients with type I, III, and V HL, and TG levels were significantly higher in patients with type I and V HL. The apo B-48/TG ratio was significantly higher only in patients with type III HL compared with other types of HL (p<0.001), and was statistically significant among the other clinical indices (AUC-ROC value, 0.895; cut-off value, 0.110). Conclusion: The apo B-48/TG ratio is a novel and useful marker for detecting type III HL even after the initiation of lipid-lowering interventions.Journal of atherosclerosis and thrombosis 08/2012; 19(9):862-71. DOI:10.5551/jat.13052 · 2.73 Impact Factor
Article: Effect of Probucol on Antioxidant Properties of HDL in Patients with Heterozygous Familial Hypercholesterolemia[Show abstract] [Hide abstract]
ABSTRACT: High density lipoprotein (HDL) has multi-antiatherogenic effects such as antioxidation and anti-inflammation, in addition to being a key mediator of reverse cholesterol transport. Probucol, known as a lipid lowering drug, is also a potent antioxidant, but it decreases serum HDL cholesterol (HDL-C) levels. To elucidate the effect of probucol on antioxidant properties of HDL, we investigated the function of HDL derived from patients with heterozygous familial hypercholesterolemia (FH) who have been treated with probucol. Probucol-treated FH patients (n=21) showed a 47% reduction of serum HDL-C levels compared to probucol-untreated FH patients (n=15). High performance liquid chromatography (HPLC) analysis revealed that probucol diminished HDL particle size compared to the non-treated group. Antioxidant capacity of HDL was evaluated by its effect to protect reference LDL from oxidation induced in the presence of an oxidizing agent, AAPH. The HDL derived from the probucol-treated group demonstrated a significantly prolonged time to start oxidation by 112%, decreased the maximum oxidation rate by 14%, and lowered the maximum concentration of conjugated dienes formation by 15%. Furthermore, HDL-associated paraoxonase 1 (PON1) activity, but not platelet-activating factor acetyl-hydrolase (PAF-AH) correlated with these measurements of HDL anti-oxidative activity. Treatment with probucol in vitro and inhibition of PON1 activity demonstrated that probucol in HDL particles and increase of PON1 activity might largely contribute to the increase of HDL anti-oxidative activity. Probucol reduced HDL-C levels and HDL particle size in patients with heterozygous FH, while it concomitantly enhanced HDL anti-oxidative properties, possibly through increasing PON1 activity.Journal of atherosclerosis and thrombosis 07/2012; 19(7):643-56. DOI:10.5551/jat.12807 · 2.73 Impact Factor
Article: Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease.[Show abstract] [Hide abstract]
ABSTRACT: Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR). Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4 ± 5.9 µg/mL) was significantly higher than in those with hyperthyroidism (5.1 ± 3.5 µg/mL; p<0.01) and normal subjects (4.7 ± 3.7 µg/mL; p<0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.Journal of atherosclerosis and thrombosis 07/2012; 19(10). DOI:10.5551/jat.12757 · 2.73 Impact Factor
Top Journals
Osaka University
Suika, Ōsaka, Japan
- • Health Care Center
- • Graduate School of Medicine
- • Department of Internal Medicine
- • School of Medicine
Osaka City University
Ōsaka, Ōsaka, Japan
- • Department of Cardiovascular Medicine
- • Graduate School of Medicine
- • Second Department of Internal Medicine
University of Texas Medical Branch at GalvestonGalveston, Texas, United States


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Most brutal girl fight ever
I have seen a lot of girl fights and this is without question the most brutal girl on girl fight I have ever seen.
Added 1428 days ago 359,583 views
markcus001 Video uploads: 459 http://imagetwist.com/p/Markcus
Video category: Fight Videos Browse video tags: girl fight, cat fight, girl blood, blood, punch
alexandria76 - 1041 days agoFINALLY FOUND MY PERFECT MASTURBATION MATERIAL! Fuckyeah!!
Tom - 116 days agoI want the looser bitch to deepthroat me
rectal prolapse - 280 days agothat was so weak im sorry but ive seen way better fights just watch queen of the hood any of them are better
Iraq - 310 days agoUSA shit crazy poeple I
obviously - 378 days agoShe didnt stand a chance against that fucking cavetroll.
Simple - 515 days agoTrash
Xray - 582 days agoFAT girl wins , Little girl should have used Fat girl's weight to her advantage.
>.< - 603 days agofelony fights isn't fake haha you stupid prick
Ivanator - 699 days agoGirls suck at fighting.........even when they are fat ugly dykes!! Boooooo!! You cunts are useless!! Not even fuckable! Barf!!
punishers - 714 days ago"most brutal girl fight ever" doesn't have to be "most" "brutal" "ever"
"....this is without question...." it is with question
unatural lesbian bitches
that's not "fight"
HeAin'tHeavy - 799 days agoI was distressed that not one of these females had their tops and bras ripped and shredded. This was the type of fight to have titties displayed.
Obviously - 846 days agoNot surprise the one who looked and sounded like a man won
Danny Degos - 859 days agowomen cant punch!!!
5pawsakademy - 879 days agothis is one off the roughest fight ever they should have gone the distance and get this little bitch to eat some pussy good
TheProfessor - 890 days agoHey Nocturdnal, please SHUT THE FUCK UP you stupid retard, your probably just some retarded, illiterate, pimple popping, inbred product of another family incest rape, 12 year old, mouse dick gook, dink, chink, turd, or shit skin camel jockey dune coon by the way you talk/type, you make NO fucking sense whatsoever with your corn ball statement and you certainly cant spell for shit! It's spelled R-E-S-T-R-A-I-N-T and C-O-M-R-A-D-S ya fucking R-E-T-A-R-D!!!
SaTaNsBatBoy - 890 days agoFirst of all you retards it IS staged, Second you can easily tell cuse that big giant butch bitch bull dyke SPIC turd man was barely SLAPPING that ugly little retarded jew tomboy dyke fool, third who gives a shit, as soon as you see a bimbo in a fake ass Ref uniform ya just KNOW it's fucking FAKE and will be as lame as this shit was! You guys really ARE pathetic LOSER queer cum guzzling faggits
Nocturnal - 900 days agowe only fight to become stronger to protect the misfourtunate, young, elderly, and ill. we fight with restaint, caution, and regard for our conrads well being. we train to take a beating by taking beatings, the train for real dangers through simulating such, and when the danger is real we are prepared with our hearts reinforcing our will to prevail victorious over all oppression even to the death of the oppressor if they chose not to fall. Still to those that will kneel healing we offer to them through family bonds and acceptance not of what they were not but what they have become. there is no other reason to fight!
Nohbdy - 921 days agothat mexican bitch is a straight up man.
Sissy boy - 961 days agoIt is very brutal, if I was punced so much times I would just die.....:(
Sissy boy - 961 days agoA nasty girl like these beat me up a mounth ago only because I am feminine sissy. i couldn't protect my self at all, only just crying and screaming for help and mercy...Was horrible, my eyrs were black, my nose and mouth bleading....just horible thing.
Jandalz - 973 days agoHer first fight? Do you think she is going to do it again?
CyberSickness - 996 days agomorena wins!
grim guy - 1021 days agoseen two 15 year old girls go at it one had a glass bottle and a brick the other had keys in-between her fingers! best fight ive ever seen
alexandria76 - 1041 days agoFINALLY FOUND MY PERFECT MASTURBATION MATERIAL! Fuckyeah!!
The Judge - 1051 days agoThey Both can't Fight Fo Shit.
Jerry - 1056 days agoJerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry Jerry !
fuckstick - 1076 days agoThe fight believe it or not was staged. She didn't really hit her hard, but did hit her, and they used various speeds and dropped frames to make it look like she was hitting her. I have a friend who worked for that company and explained it all to me.
yep - 1076 days agostupid bitch desreves the beatinglol....that amazon girl kicked her ass good
the heck.... - 1087 days agoplease... kill yourselves
Ivan Headache - 1107 days agoHey Morons:
"You are lucky the girl did'nt die"
FUCKING DRAMA QUEEN, get real missy. It was handbags at 5 paces ffs.
Morons - 1109 days agoThat was not a fight moron! You were basically watching a beating. You are lucky the girl didn't die. You guys are fucking stupid. Don't call it a fucking fight!!
Mike Hunt - 1114 days agoI would so fuck the cute one in the black top. What a very sexy ass. Very attractive girl.
pooped - 1126 days agolol that lipstick lez tottaly started gigglinging in the middle of getting her ass kicked lolol wtf
PVFC - 1147 days agoThat was a mis-match!!
How was that sexy cute girl in a black vest top ever going to beat that obese ugly fat bloke in the white top?
The fat cunt only had to sit on her and he'd win. Even a fucking elephant pales in size to that huge whale. What happened after the fight was the massive bulk still beeched or did they get the blubber back into the water.
WTF - 1159 days agoHy we are stupid ugly girls puching each other in the face and we are so happy when we spit blood hihi yaaay People = Shit
hot hot hot - 1424 days agobitch got beat on
sdsdsd - 1428 days agoGo watch womens MMA and look up Cristiane Cyborg santos, this is garbage lol fucking joke
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subset: commoncrawl


text: The area is weird, there was a gun shot mark at the door of the building close to the hostel. Far from the good points in Turin. The olympic village is abandoned. I was totally afraid to walk alone in that region, weird people around all day, army and police cars everywhere. The hostel structure is new, they have fans... More


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February 18, 1996 in Nation/World
Best Solution For Avoiding Floods: Move
Inland Northwest flood victims cannot be forced to move above flood plains unless their homes were severely damaged.
But disaster relief workers want flood victims to consider such a move anyway. Less drastic options such as flood-proofing homes and building better dikes near residential areas also are possible through federal disaster relief money.
George Currier, Benewah County's water-weary civil defense coordinator, hopes some flood victims decide to move out of the flood plain. "It's good sense that you should go above it."
Federal help now being offered in the region is a ripple effect from 1993's horrendous Mississippi River floods.
After those floods, Congress decided more must be done to prevent disasters. So it offered cash to local governments to be distributed by states in the form of mitigation grants.
"Mitigation is the guardrail at the top of the hill," said Doug Gore of the Federal Emergency Management Agency. "Preparedness is the ambulance at the bottom."
Gore manages FEMA operations in North Idaho's 10-county disaster area. Gov. Phil Batt requested mitigation money well before flood waters receded last week.
It's too soon to say how much money will be available. The kitty will equal 15 percent of all the federal money spent on the disaster, not including repairs to federal highways.
Some property simply can't be defended from floodwaters. If local officials decide that's the case, they could offer to buy out people whose homes were destroyed.
After a Rapid City flood that killed 239 people in 1972, the federal government provided $40 million to clear out the flood plain. Congress doled out another $200 million to move entire towns after the '93 Midwest floods.
Such an evacuation, however, is the most expensive option. Instead of moving a home to higher ground, the higher ground can be brought in.
Ryan Hopp knows about that.
When Hopp wanted to put up a mobile home in Cataldo, where he bought an auto shop, Kootenai County building inspector Dave Daniel insisted that he put five feet of dirt under it.
It cost Hopp $4,000. But "he was the only one in town who stayed dry," reported neighbor Lee Ann Baysinger.
Baysinger wasn't so lucky. She's either going to have to elevate her badly damaged home, or move.
The U.S. Small Business Administration will loan homeowners the money to elevate their homes. That allows people to stay near the water, where they often have an emotional as well as a financial investment.
"Flood-proofing is another option," said Gore. "For example, you could put a stand pipe over the drain in your basement, so the water rises in that" instead of the living space.
FEMA's new emphasis on prevention includes sending an expert to disaster zones. In North Idaho's case, it will be Sherryl Zahn who writes a report on ways communities could head off future flood damage.
Some communities will want money to build dikes. Cataldo residents, for example, would like a structure to hold back water under the freeway bridge where they sandbagged up until the last minute.
Such proposals will be considered, said Gore, but he cautioned that the dikes would have to be well-designed - "not every pile of dirt is a dike." Any new dikes would also have to cost less than the damage they would prevent.
Some government efforts would cost very little. Among them is public education. That would have helped a family from Kingston that didn't know it was moving into a flood plain two years ago. The family's yellow house was four feet deep in water after the floods.
Gore believes that local governments need to budget for disaster prevention, just as they plan for disaster assistance and the next purchase of a fire truck.
FEMA, he said, "can't solve all the problems." It can't help at all unless a flood is declared a national disaster.
"This is a one-shot deal," he said of the mitigation grants. "Ideally, this should prime the pump."
, DataTimes ILLUSTRATION: Color photo
The following fields overflowed: BYLINE = Julie Titone Staff writer Staff writer Rich Roesler contributed to this report.


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Combat Zone Wrestling and Womens Superstars Uncensored head to iPPV THIS SATURDAY live from Voorhees, NJ!
For the first time ever, on Wednesday, August 26, the CZW world title will be defended at Dojo Wars as champion Matt Tremont defends against...
Combat Zone Wrestling and Women Superstars Uncensored return Saturday, September 12 in Voorhees, NJ.
CZW presents Tournament of Death 14 at the Ultraviolent Underground in Townsend, DE on Saturday, June 13th.
In the Best of the Best finals Mike Bailey defeated Jonathan Gresham in a match that's worth ordering the iPPV by itself.
'2300 Arena' has had many names over the years, but CZW is the professional wrestling company with the most events held inside its walls.
Former CZW world heavyweight champion Biff Busick will be getting a tryout with WWE at the Performance Center in Orlando next week.
CZW World Tag Team champions OI4K vs. The Young Bucks on February 21, 2015.
CZW world champion BLK Jeez defends against former champion and Front leader, Sozio.
January 5, 2014 – Combat Zone Wrestling – BJW For MASADA at the Yokohama Red Brick Warehouse in Yokohama, Kanagawa, Japan. Kazuki Hashimoto & Ryuichi...


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Michael Conroy/Associated Press
Fit for Seattle: Linebackers
With a bevy of young talent at the position, linebacker is another seemingly low priority for Seattle. BYU's Kyle Van Noy could have been a first-round pick if he declared last year, but an up-and-down performance in 2013 — and at the combine — may push him to the mid to late rounds in May. A natural pass-rusher, Van Noy could earn a spot in Seattle behind Bruce Irvin.


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Photo by Romulo Yanes
Leave a Review
This recipe is more like a salad than an appetizer, none the less very good, but I agree with another reviewer way too many beets, defintely can be cut in half.flag if inappropriate
This recipe has ruined me for cooked beets! After having beets prepared this way, cooked beets just taste mushy and mild. I've now used these sliced beets with vinegar in many salads. There are endless variations and the sweet crunchy beets cannot be beat!flag if inappropriate
I love everything about this recipe, except the endive. I just left it out, and thought it was fantastic - made for a dinner party and everyone cleaned their plates. Would have given it a 4 if the endive were not in the original.flag if inappropriate
Rather blah really. And this makes WAY more sliced beets than 4 people can handle. Think about it- 3 beets sliced paper-thin? We had beets for days. One beet is plenty for the spare, elegant plating that this recipe requires.flag if inappropriate
Ok, this is my new favorite beet recipe. Next time I'll try a touch of Truffle Oil which often pairs well with certain cheeses.flag if inappropriate
I've made this recipe several times, and it's always been a hit. I've added onions and capers (like beef carpaccio) and that's worked well, too.flag if inappropriate
This was so delicious! Made for a group of girlfriends and none of us had ever made anything with raw beets before-we loved it!flag if inappropriate


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"The current survey process in declaring an immediate jeopardy is extremely inconsistent from state to state, which could very well result in systematic biases between areas in the number of hospitals that receive citations and are excluded from the VBP program, wrote Pollack. (More on this in a future column.)
Premier Health Alliance wants CMS to not penalize hospitals that remediate an immediate jeopardy before their survey.
7. There are big problems with the three categories of measures due to kick in for 2014: measures for mortality, the Agency for Healthcare Research and Quality metrics such as having patients with post-operative respiratory failure, and hospital acquired conditions, the AHA's Pollack says. "The agency provides virtually no detail on how it proposes to score" hospitals performance," he says.
8. The proposed minimum of 10 cases a hospital must have to be included for certain metrics is too low, and is inconsistent with current requirements on Hospital Compare, which calls for at least 25, several organizations complained. "With less than that number the site (Hospital Compare) states that CMS cannot 'be sure how well a hospital is performing,' " Pollack wrote.
9. The regulations would allow CMS to have access to quality improvement organization information, which Pollack says would "strip many of the confidentiality safeguards and go against Congress' original intent in putting the confidentiality provisions in place."
Comments are moderated. Please be patient.


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The Rigging Triangle Exposed: The JPMorgan-British Petroleum-Bank Of England Cartel Full FrontalSubmitted by Tyler Durden on 12/31/2014 09:30 -0400
To all those wondering if everything is rigged, we have a very simple answer: Yes.
- 275 comments
- Read more
- 98580 reads
Massive 1,500 Ton Gold Vault For Sale In The Heart Of London, One Previous Owner, Asking £4,500,000 O.B.O.Submitted by Tyler Durden on 12/26/2014 15:16 -0400
As a result of Deutsche Bank's gold-rigging problems, the German bank's practically brand spanking new Singapore gold vault, just over a year old, is about to go on sale. But while one can debate when the brand new storage facility will see a "for sale" sign attached to the main vault door, one thing is clear: Deutsche Bank's massive, and even newer, gold vault in London is already looking for offers. According to Reuters, Deutsche Bank is "open to offers for its London-based gold vault following the closure of its physical precious metals business."
- 54 comments
- Read more
- 18024 reads
Armed Robber Flees After Failed Attempt To Rob Of Zurich BankSubmitted by Tyler Durden on 12/24/2014 12:30 -0400
Update: the robber has supposedly managed to flee the scene.
While it has yet to make the major wires, there are numerous reports of an attempted robbery taking place at a branch United Mizrahi Bank Schweiz on Nyushelershtrasse in Zurich. According to RIA the scene has been cordoned off with a large police presence as seen in the photos below. As RIA further adds, the police is preparing to storm the bank building, where, allegedly armed robbers have barricaded themselves and may have taken hostages.
- 52 comments
- Read more
- 7940 reads
2014 Year In Review (Part 2): Will 2015 Be The Year It All Comes Tumbling Down?Submitted by Tyler Durden on 12/21/2014 14:53 -0400
- Abenomics
- Alan Greenspan
- Albert Edwards
- Ally Bank
- Andrew Cuomo
- Andrew Ross Sorkin
- Art Cashin
- Bain
- Bank of England
- Bank Run
- Barack Obama
- Barclays
- Barry Ritholtz
- Bear Stearns
- Belgium
- Ben Bernanke
- Ben Bernanke
- Berkshire Hathaway
- Bill Dudley
- Bill Gates
- Bill Gross
- Bitcoin
- Black Swan
- Blackrock
- Blythe Masters
- Boeing
- Bond
- Bulgaria
- Central Banks
- Charlie Munger
- Chelsea Clinton
- China
- Citigroup
- Cliff Asness
- Cohen
- Comcast
- Corruption
- Counterparties
- Credit Default Swaps
- Credit Suisse
- Creditors
- Darrell Issa
- default
- Dell
- Demographics
- Deutsche Bank
- Elizabeth Warren
- Enron
- Equity Markets
- Erste
- European Union
- Fail
- Fannie Mae
- Federal Reserve
- Financial Overhaul
- Fisher
- Ford
- Fox News
- Freddie Mac
- Freedom of Information Act
- GE Capital
- General Mills
- General Motors
- George Soros
- Germany
- Global Economy
- goldman sachs
- Goldman Sachs
- Government Motors
- Greece
- Gundlach
- Hank Paulson
- Hank Paulson
- headlines
- Hong Kong
- Housing Market
- Hungary
- Iceland
- Insider Trading
- Iran
- Iraq
- Italy
- Jamie Dimon
- Janet Yellen
- Japan
- Jim Chanos
- Joe Biden
- John Hussman
- John Maynard Keynes
- Jon Stewart
- Kappa Beta Phi
- Krugman
- Kyle Bass
- Kyle Bass
- Larry Summers
- Ludwig von Mises
- Mark Spitznagel
- Market Conditions
- Martial Law
- Matt Taibbi
- Maynard Keynes
- McDonalds
- MF Global
- Michael Lewis
- Middle East
- Milton Friedman
- Monetary Policy
- Monetization
- Moral Hazard
- Morgan Stanley
- Nancy Pelosi
- Nassim Taleb
- national security
- New Orleans
- New York Fed
- New York Times
- New Zealand
- Newspaper
- Niall Ferguson
- None
- Obama Administration
- Obamacare
- Paul Krugman
- Pension Crisis
- Peter Boockvar
- President Obama
- Rahm Emanuel
- Real estate
- Recession
- recovery
- Repo Market
- Reserve Currency
- Richard Fisher
- Robert Gates
- Ron Paul
- Sam Zell
- Savings Rate
- Saxo Bank
- Scott Alvarez
- Securities Industry and Financial Markets Association
- Sergey Aleynikov
- Seth Klarman
- Shadow Banking
- Simon Johnson
- Sovereign Debt
- Sovereigns
- St Louis Fed
- St. Louis Fed
- Stephen Roach
- Stress Test
- Subprime Mortgages
- Switzerland
- Testimony
- The Onion
- Tim Geithner
- Timothy Geithner
- Trade Deficit
- Transparency
- Turkey
- Ukraine
- Unemployment
- Unemployment Insurance
- Universa Investments
- Uranium
- Verizon
- Vikings
- Vladimir Putin
- Warren Buffett
- Warsh
- White House
- WorldCom
- Yen
- Yuan
- Zurich
Despite the authorities' best efforts to keep everything orderly, we know how this global Game of Geopolitical Tetris ends: "Players lose a typical game of Tetris when they can no longer keep up with the increasing speed, and the Tetriminos stack up to the top of the playing field. This is commonly referred to as topping out."
"I'm tired of being outraged!"
- 129 comments
- Read more
- 31939 reads
Fog of WarSubmitted by Bruce Krasting on 12/18/2014 22:42 -0400
The one thing that Jordan can't do in this war is appear to be weak.
- Bruce Krasting's blog
- 89 comments
- Read more
- 15482 reads
ObamaCar: Automobile Insurance Subsidized Hope ActSubmitted by hedgeless_horseman on 12/18/2014 13:43 -0400
"My name is Jasmine and I support President Obama's move to give affordable auto insurance for everyone."
- hedgeless_horseman's blog
- 65 comments
- Read more
- 10061 reads
Swiss Central Bank Plunges Into NIRP, Sends Deposit Rates Negative, Scrambles Against Safe-Haven Capital FlightSubmitted by Tyler Durden on 12/18/2014 10:43 -0400
Everyone thought that any major monetary policy surprises and/or capital controls today would come from Putin during his annual press conference. Boy were they wrong: just after 2 am Eastern, none other than the Swiss National Bank joined the ranks of the ECB in scrambling to stem the wave of capital flight, not to mention the cost of money, when it announced it too would start charging customers for the privilege of holding cash in its banks, when it revealed a negative, -0.25% interest rate on sight deposits: a step which according to the SNB was critical in maintaining the 1.20 EURCHF floor.
- 155 comments
- Read more
- 24964 reads
Swiss Gold No - Repatriation, Demand from Russia, India and China More ImportantSubmitted by GoldCore on 12/01/2014 12:45 -0400
Switzerland's 'Save our Swiss Gold' referendum was convincingly rejected yesterday by the Swiss electorate following an aggressive anti-gold campaign in recent weeks that had been closely watched both in Switzerland and abroad.
Unusually, it involved the Swiss National Bank (SNB) very actively, and ultimately successfully, trying to convince the electorate along with the main political parties to return a 'no' vote.
- GoldCore's blog
- 37 comments
- Read more
- 10800 reads
Swiss Gold Referendum Fails: 78% Vote Against "Protecting The Country's Wealth"Submitted by Tyler Durden on 11/30/2014 20:10 -0400
Whether as a result of an unprecedented scare campaign by the Swiss National Bank (most recently reinforced by Citigroup), or due to confidence that Swiss gold is as safe abroad as it is at home, or simply due to good old-fashioned "hanging chads", today's most awaited event has come and gone and the result - according to early projections by Swiss television SRF - is that the Swiss population overwhelmingly rejected a referendum to force the Swiss National Bank to hold some 20% of its reserves in gold in a landslide vote, with about 78% voting against what AP politely termed "protecting the country's wealth by investing in gold."
- 487 comments
- Read more
- 70284 reads
Swiss Yes Vote Possible - First "Gold Rush" Of 21st Century?Submitted by GoldCore on 11/27/2014 15:30 -0400
In the case of a "yes" vote, gold prices are likely to surge. Analysts do not believe a yes vote is possible. However, analysts have got the mood of the people wrong in many referendums both in Switzerland and throughout Europe in recent years.
- GoldCore's blog
- 8 comments
- Read more
- 3384 reads
Ukraine Central Bank Admits Gold Outflow, Calls It "Optimization Of Reserve Structure"Submitted by Tyler Durden on 11/24/2014 11:16 -0400
A week after we reported that the head of the Ukraine central bank admitted in an unofficial, informal interview that Ukraine's gold is gone, all gone, moments ago the Central Bank revealed that, sure enough, the gold holdings in the civil war-torn country have tumbled, as a result of a decision in September to "increase the share of US dollars in a reserve basket", or in other words, to sell the gold. Just don't call it that: in fact, as of today we have a brand new buzzword for gold liquidations: "optimization of international reserves."
- 114 comments
- Read more
- 12300 reads
122 Tonnes of Gold Secretly Repatriated to NetherlandsSubmitted by GoldCore on 11/24/2014 09:53 -0400
- Backwardation
- Bank of Japan
- Central Banks
- China
- Commodity Futures Trading Commission
- European Central Bank
- Eurozone
- Federal Reserve
- Futures market
- Germany
- Hong Kong
- Japan
- Krugman
- Lehman
- Netherlands
- Paul Krugman
- Precious Metals
- Quantitative Easing
- Reuters
- Swiss National Bank
- Switzerland
- World Gold Council
- Zurich
As the debate regarding whether or not Switzerland should keep the bulk of its gold reserves at home on Swiss soil reaches it's climax - the referendum takes place on Sunday - it is telling that the Dutch announced on Friday that they have just secretly repatriated 122 tonnes of their sovereign gold reserves from New York back to Amsterdam.
- GoldCore's blog
- 8 comments
- Read more
- 3054 reads
The Need To Escape Collapsing EmpiresSubmitted by Tyler Durden on 11/21/2014 21:07 -0400
I believe aggressive empires with bloated bureaucracies, unsustainable debt loads, and chronic military overreach cannot compete against the now capitalist, relatively free-market Asia. The truth is Asia is rising and the debt-ridden Western democracies are failing. The world is an interesting place, and the American Dream still lives - just not so much in the United States any longer. But countries can change for the better; tyrannies are overthrown, and the Internet reformation is a big advantage for people desiring freedom and honest information around the world.
Don't fence yourself in.
- 142 comments
- Read more
- 21196 reads
"Paper Gold" And Its Effect On The Gold PriceSubmitted by Tyler Durden on 11/13/2014 21:48 -0400
Gold dropped to new lows of $1,130 per ounce last week. This is surprising because it doesn't square with the fundamentals. China and India continue to exert strong demand on gold, and interest in bullion coins remains high. In other words, it doesn't add up.
- 80 comments
- Read more
- 24832 reads
This Is What Happens When Trying To Get To The Bottom Of The UBS Gold-Rigging ScandalSubmitted by Tyler Durden on 11/10/2014 00:49 -0400
As reported previously, and as had been suspected for years, the gold manipulation cartel is slowly breaking apart, and courtesy of the FT, we now know at least one individual directly implicated in Swiss gold-rigging: the former head of UBS's gold desk in Zurich, André Flotron. So as part of our diligence, because apparently no other media will touch the topic of gold rigging until and unless it is shoved in their face on a, ahem, silver platter, because after all the subject matter is just too "conspiratorial", we decided to ask Mr. Flotron some on the record questions, and sent him an email. This is the response we got...
- 135 comments
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- 65813 reads


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July 4th Fireworks After-Party at Hudson Terrace
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for July 4th Fireworks After-Party was Thursday July 4, 2013 / 10:00pm.
Most Popular Foodie Event Nearby
Cruise to Oktoberfest on the Beach in Highlands, N.J., With Seastreak Catamarans
- Full Price:
- $17.00 - $45.00
- Our Price:
- $11.90 - $31.50
You've never celebrated Oktoberfest like this before -- Seastreak Catamarans is launching its first… More
Venue Details
About the Ticket Supplier: iAdventure.com
iAdventure is an innovative event company that produces unique and affordable event experiences as odes to our favorite foods, libations, traditional and out-of-the-box holidays and charitable causes. By using our own passions as inspiration and our rolodex of resources and friends around the city as our competitive edge, iAdventure is able to offer exclusive and exciting events for urbanites adventurous enough to attend them.


text:
Josh Condie - The Microsoft Deployment Toolkit (MDT) provides a unified collection of tools, processes, and guidance for automating desktop and server deployments. In addition to reducing deployment time and standardizing desktop and server images, MDT offers improved security and ongoing configuration management.
With MDT 2013 now available, there are significant new capabilities:
You can use MDT to deploy the Windows 8.1 and Windows Server 2012 R2 operating systems using the LTI, ZTI, and UDI deployment methods. Roles and features specific to Windows 8.1 and Windows Server 2012 R2 are available in the role list.
MDT supports the use of the Windows ADK for Windows 8.1 to deploy operating systems. The Windows ADK for Windows 8.1 includes the Deployment Tools such as the Deployment Image Servicing and Management (DISM) tool, the Windows Pre-installation Environment (Windows PE) and the User State Migration Tool (USMT).
ZTI and UDI deployment methods in MDT support integration with System Center 2012 R2 Configuration Manager, including new capabilities such as multiple Network Access Accounts.
Unified Extensible Firmware Interface (UEFI) is a specification that defines a software interface between an operating system and platform firmware. UEFI is a more secure replacement for the older basic input/output system (BIOS) firmware interface present in some personal computers, which is vulnerable to malware that performs attacks during the boot or power on self-test processes.
By default, MDT creates the appropriate partitions to support computers running UEFI. MDT supports UEFI versions from 2.0 up to 2.3.1. UEFI 2.3.1 is a newer version of UEFI that will be used on Windows 8 logo–compliant computers.
Here are 2 videos to help you get very familiar with the MDT process. *Note - They are based on the 2012 version of the Toolkit, but still very applicable.
<script src="http://technet.microsoft.com/en-us/videoembed/tdbe12-deployment-day-session1" type="text/javascript"></script>
<script src="http://technet.microsoft.com/en-us/videoembed/tdbe12-deployment-day-session2" type="text/javascript"></script>
Download resources to help you get the most out of MDT 2013. This package includes:


text:
You could add a wiki page with this. But please give a help there, it took me a while I had to use the textual smaller/larger links to have the bounding box change.
You could also make a report/quick report on places that opens this page in your browser. That would give you the option to create a plugin for gramps that makes your applet more visible and allows you to share the work with new users.
Hm, I realize I left out a couple of points I meant to make...
- Place databases like geonames.org go down to the level of cities or
towns. Geocoding (computing coordinates based on address) is
notoriously inaccurate and often fails, especially on historical
addresses. GRAMPS users will often have information more precise than
city, but less precise than an actual building location. Perhaps just a
street name, or a particular block, or a distance from landmark, etc. A
tool like this is useful for determining approximate coordinates that
are better than just the city coords using that information.
- Besides adjusting zoom level based on precision of coordinates,
GeoView could also display the area of uncertainty, similar to the
bounding box I draw (though a circle, if possible, would be more
visually pleasing). That raises awareness that, like most Places, the
coordinates don't reference just a single, specific point, but rather a
general area of interest around that point, the size of which can vary
depending on the Place being referenced.
Dave Walton wrote:
> Howdy folks,
> This is semi-related to several different conversations that have taken
> place here recently. So I thought I'd share, in case anyone here is
> interested...
> For some time, I've been annoyed by the pointless over-precision of a
> lot of the coordinate data out there. I just doesn't make sense to give
> the coordinates of an entire country to within two inches. So I made
> this tool to help me find coordinates with more reasonable precision.
> (Thank you, Serge, for calling my attention to Mapstraction!)
> http://www.digger.net/projects/locator
> I can imagine several ways this might be useful to GRAMPS:
> - As a feature of GeoView, or perhaps a GeoView-enhanced place
> completion tool, it could help GRAMPS users find coordinates of places.
> - There was an idea recently about some sort of GRAMPS project places
> database. If that were to happen, something like this could be useful
> as part of the UI for building and maintaining that database.
> - Some of my code may (or may not) be useful in GeoView, such as
> picking a zoom level based on the level of precision of the coordinates.
> (I confess that I have no idea what GeoView can currently do. I am
> using Kubuntu, so I am missing a long list of dependencies to get
> gtkmozembed working.)
> Dave
> -------------------------------------------------------------------------
> This SF.net email is sponsored by: Microsoft
> Defy all challenges. Microsoft(R) Visual Studio 2008.
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> email@example.com
> https://lists.sourceforge.net/lists/listinfo/gramps-devel
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text:
Hey Everyone,
Another fun walk with the California Native Plant Society coming up! This walk focuses on plant ID of native plants rather than edibilty aspects
Always Eddie
Springtime blooms will ease the first half has a sunny 500 foot climb through manzanita. We hope to see Sonoma Sage, Pitcher Sage, Fritillaria, Manzanita and Ceanothus in bloom. There are restrooms at the trailhead. Bring water, sunscreen, snack and hat.
Meet at Skunk Hollow River Access at the north end of the Salmon Falls Bridge. It's about 30 minutes from Sunrise and Hwy 50. $12 for parking or State Park Pass. In the past there has been limited free parking along the shoulder of Salmon Falls Road on the south side of the bridge. Allow an extra 10 minutes driving if planning to use the limited free parking (no promises on free parking).
Driving directions from Sacramento.
- Travel east on Highway 50
- Take exit 30B -El Dorado Hills Blvd.
- Drive north on El Dorado Hills Blvd. for about 3.5 miles to Green Valley Rd.
- Continue north crossing Green Valley Rd, and El Dorado Hills Blvd becomes Salmon Falls Rd.
- Continue on Salmon Falls Rd about 6 to the Salmon Falls Bridge
- Cross the bridge and turn right into the Skunk Hollow parking area.
Thanks for all the information. Wish I could have joined you on the sweet water trail.
1 · March 22, 2013
Perfect day observing nature (plants mostly) along the Salmon Falls bridge area (Skunk Hollow) Most of the manzanita blossoms had gone but a few still hung on at this elevation, the berries are starting to ripen (half green) Don't know if the member of our group was suppose to eat the unripe ones- said they tasted a little sour. Saw pitcher sage (Lepechinia calycina) and Sonoma sage (Salvia sonomensis) which both had very unique smells that were very refreshing and calming.
0 · March 22, 2013
I started the group because there wasn't any other type of group like this. I've met some great folks in the group who have become close friends and have also met some amazing business owners.
— Bill, started New York City Gay Craft Beer Lovers
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text:
Discover the history of Burgundy in colourful paintings—from the first to the fifteenth century, from the legendary first King of Burgundy, Trophimus, to the last Duke of Burgundy, Philip the Fair!
The Flemish Chronicle of Philip the Fair is a masterpiece of the Ghent-Bruges School and is classified under the rare genre of medieval children's books. This alone makes it valuable—not to mention the rich illustrations and the illuminator's great artistic skill. Philip the Fair was seven years old when he received this richly illuminated chronicle, an educational reader intended for the future head of the Burgundian dynasty, which was already over a thousand years old.
In the Flemish Chronicle of Philip the Fair you will discover the fascinating history of Burgundy from a completely new perspective. See it for yourself order the informative documentary portfolio with an original facsimile leaf and preview it, at no obligation, for fourteen days.
Perfect Gothic illumination, tangibly raised gold lettering, a matchless collection of visual typologies, an incomparable interplay of gold and azure ink calligraphy: the content and ornamentation of the Peterborough Psalter is so unique that no other publisher of facsimiles has yet dared to reproduce this manuscript.
Quaternio Lucerne has taken on the challenge—you can already feel the three dimensions of the facsimile in the documentation portfolio, as you run your fingers across the sublime, raised gold calligraphy on the parchment-like paper.
The Peterborough Psalter is so rich in gold ornamentation that it has only been in the exclusive libraries of ruling European houses, from Pope John XXII (1318) to Napoleon (1805). What is it all about? Learn more and order the documentation folder with a four-page facsimile section without any obligation on your part.
Feel the tangibly raised gold calligraphy and admire eight miniatures, the splendid coat-of-arms in gold and silver and the golden initial page – you get all this with the original fine art facsimile double leaf in the documentation folder. Get an idea of the extraordinary quality of this outstanding fine art facsimile edition! Order the documentation folder without any obligation on your part.
Eberbach Abbey
15 August to 29 October 2015,
open all days, 10 am–6 pm
The interior scenes of "The Name of the Rose" were filmed in this former Cistercian Abbey. Come to Eberbach Abbey and see the special exhibition on the fine art facsimile edition of the Golden Gradual of Gisela von Kerssenbrock – Germany's most beautiful choir book from the Middle Ages.
Turn yourself the pages of the facsimile edition, see a video on the making of the facsimile and hear the songs of the nuns.
Clairvaux. L'aventure cistercienne
Rue de la Cité, FR-10000 Troyes
Still open until November, 15 2015
In 2015, Aube en Champagne celebrates the 900th anniversary of the foundation of Clairvaux abbey. On this occasion runs a major exhibition presenting more than 150 documents and rare objects.
The Fine Art Facsimile edition of the Flemish Chronicle of Philip the Fair is at the visitor's disposal all along the exhibition. Do not miss the opportunity!
Singen wie die Engel.
Der Codex Gisle – Eine mittelalterliche Musikhandschrift aus dem Kloster Rulle
Diözesanmuseum Osnabrück
Domhof 12, 49074 Osnabrück
Still open until October 4, 2015
The exhibition shows The Golden Gradual of Gislea von Kerssenbrock. Seize the opportunity and admire the original of one of the most beautifully decorated music manuscripts from the Middle Ages while leafing through the true-to-the-original fine art facsimile edition by Quaternio Verlag Luzern.
Join us on facebook!
The making of the fine art facsimile edition of the Golden Munich Psalter has been filmed by the Swiss Television station. On March 24, 2011 the report Hohe Kunst der «Fälschung» – wie das Faksimile einer Prachthandschrift entsteht was boadcast in »Kulturplatz« on SF 1.


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deal over
deal over!
We're turning three! Celebrate with one of our favourite local businesses of the last three years:
Marlon Brando seared and scintillated on the silver screen as the prizefighter Terry Malloy in On The Waterfront -- winner of eight academy awards. If you're hungering for the star treatment, enter the ring at the prestigious Cafe Shore Bar & Restaurant and enjoy an upmarket meal.
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|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | The Wire | Audio | Arcade
|Home Tags index Ricky Hatton
|Senchenko Hits Shocking KO Shot on Hatton in Nine
Manchester Arena, Manchester, England - Vyacheslav Senchenko (33-1, 22KOs) appeared to be behind on the cards and then he landed a hard shot to the body which sent Ricky Hatton (45-3, 32KOs) down f...
reviews | forums
|Hatton: I'm Here To Put a lot of Ghosts, Demons To Rest
The most endearing part of Ricky Hatton�s run as a world class fighter during his prime years was his ability to remain in touch with the working class public. That part hasn�t left him, though it ...
reviews | forums
|Hatton Says Convincing Girlfriend About Return Was Hard
Ricky Hatton admits girlfriend Jennifer Dooley took a lot of convincing that his return to the boxing ring was a good idea. The 34-year-old former two-weight world champion will contest his firs...
reviews | forums
|Shannon Cherishing Every Moment of Hatton Experience
Forget Ricky Hatton�s comeback, in 2005 this writer made his return to the gym after a 10-year gap in a bid to recapture past glories, right wrongs and, most importantly, obtain a six pack. My own...
reviews | forums
|Frank Warren on Hatton's Return, Jabs Hearn, Mitchell
Former two weight world champion Ricky Hatton returns to the ring this evening but it�s no secret that I�d rather he didn�t. �The Hitman� went unbeaten in his first 39 fights with me, culminating ...
reviews | forums
|Shannon Used Old School Training For Hatton's Return
Trainer Bob Shannon has taken Ricky Hatton back to the future in order to engineer a successful ring return tonight. Hatton takes on once-beaten Ukrainian welterweight Vyacheslav Senchenko at a ...
reviews | forums
|Hatton Vows To Keep Emotions in Check During Fight
Ricky Hatton is determined not to let his emotions get the better of him when he returns to the boxing ring against Vyacheslav Senchenko on Saturday night. The 34-year-old's personal troubles si...
reviews | forums
|Ricky Hatton is Humbled By Large Weigh-In Crowd
Ricky Hatton's wait to return to the ring is almost over as the countdown continues to his fight against Vyacheslav Senchenko on Saturday. The former world champion, whose last bout was in May 2...
reviews | forums
|Photos: Hatton, Senchenko Face To Face at Weigh-In
Ricky Hatton and Vyacheslav Senchenko both weighed in at 10st 6lb 10oz [146-pounds] for their welterweight fight at the Manchester Arena on Saturday night. Former world two-weight world champion...
reviews | forums
|Hatton: I'm Back To Make People Proud of Me Again
Ricky Hatton is hopeful his tale of personal redemption has unified fans and critics alike ahead of his boxing return on Saturday night. Hatton last stepped through the ropes three and a half ye...
reviews | forums
|Senchenko: I'm Convinced I'll Defeat Ricky Hatton
Vyacheslav Senchenko is surprised to be squaring off against Ricky Hatton in Manchester on Saturday night in light of a chance meeting between the fighters earlier this year. The pair attended t...
reviews | forums
|Ricky Hatton on Senchenko Bout: If I Lose I Will Quit!
RICKY Hatton will hang up his gloves for good if he fails in his comeback fight in front of his adoring fans tomorrow night. Hatton ends a ring exile of more than three years, when he meets Vyac...
reviews | forums
|Hatton Vows To Be Mean, Ferocious Against Senchenko
Ricky Hatton will be at his "meanest and most ferocious" for Saturday's comeback fight against Vyacheslav Senchenko in Manchester. The 34-year-old former two-weight world champion will fight for...
reviews | forums
|Photos: Hatton vs Senchenko Final Press Conference
Ricky Hatton insists he will have no fears over his punch resistance when he makes his eagerly anticipated comeback in Manchester this weekend. Ricky Hatton returns to the ring on Saturday night 3�...
reviews | forums
|Pacquiao Feels Hatton is Making Mistake in Return
Manny Pacquiao fears that Ricky Hatton is making a big mistake by returning to the ring this weekend. Pacquiao's crushing knockout win over Hatton appeared to have sent him into retirement three...
reviews | forums
|Shannon: Hatton's Reaction To First Big Shot is Key
BOB Shannon will �discover the answer to one of boxing�s biggest questions when Ricky Hatton is hit for the first time on Saturday. Shannon is the man �The Hitman� has chosen to guide him throug...
reviews | forums
|Hatton: I Have No Problem Facing Malignaggi in NY
It�s obviously no coincidence Ricky Hatton chose Vyacheslav Senchenko as the opponent for his comeback fight Saturday night in Manchester, England. It�ll be easy to compare Paulie Malignaggi�s i...
reviews | forums
|Hatton Says First Sparring Session Set Him on Course
Ricky Hatton will have no fears over his punch resistance when he makes his highly-anticipated comeback in Manchester this weekend. Former two-weight world champion Hatton takes on once-beaten U...
reviews | forums
|De La Hoya: Hatton Capable of Regaining Top Spot
BOXING great Oscar De La Hoya believes Ricky Hatton can fight his way right back to the top. Hatton makes his comeback from a three-year exile when he meets Vyacheslav Senchenko at the Mancheste...
reviews | forums
|Senchenko Says 18,000 Hatton Fans Won't Matter
VYACHESLAV SENCHENKO is using Ricky �Hatton as a stepping stone to a showdown against Amir Khan. The Ukrainian faces �The Hitman� at the Manchester Arena on Saturday night as Britain�s best-love...
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In this next installment of AMD's GPU 14 R9 line-up, Benchmark Reviews will be testing the HIS Radeon R9 280 IceQ X² OC 3GB Video Card (Model# H280QMC3G2M). As the name suggests, this particular model features the high end IceQ X2 cooler from the HIS labs and faster Core and Memory speeds. I have seen the evolution of this cooler first hand and I know it to be fully capable. Two 89mm dual axial fans and five heatpipes ensure that your temperatures will stay well within safe limits.
Tag Archive: Radeon R9 280
HIS Radeon R9 280 IceQ X² OC 3GB Video Card Review
27 June 2014
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But the Tea Party movement also supported some politically gifted challengers -- some with considerable political experience (Marco Rubio in Florida, Pat Toomey in Pennsylvania), some with none at all (Ron Johnson in Wisconsin) and some with insider connections among conservatives (Mike Lee in Utah, Ted Cruz in Texas).
On policy, the Tea Party movement has had significant impact as well. It contributed to Republican unanimity against Obamacare and against tax-rate increases.
President Obama predicted that his reelection would "break this fever" of Republican opposition to his policies. Republicans would acquiesce in what Obama seems to regard as common-sense expansions of government.
That hasn't happened. Instead, policy has moved in the other direction. Republicans were willing to accept the sequester, despite spending cuts, and then to have it only tweaked slightly in the Ryan-Murray budget agreement.
Income tax increases have been avoided on all but couples making $450,000 annually. The result is what liberals call "austerity."
Meanwhile, Obama has been repealing and revising Obamacare, whether the Constitution gives him authority or not. His signature law is disintegrating.
So Republicans, though only controlling the House and squabbling over tactics, have shifted the vector of national policy. They have had even more policy success in many of the majority of states with Republican governors and legislatures.
Tea Party spokesmen are, unsurprisingly, dissatisfied with the results - as peace advocates often were by policies of even Democratic administrations. But in American politics, policy success is never complete and almost always unsatisfactory to principled purists.
Political reporters chronicling the exhaustion of the Tea Party movement focus on the apparent weakness of primary challenges to incumbent Republican senators and congressmen. None currently seems seriously endangered except possibly 36-year Mississippi Sen. Thad Cochran.
The Tea Party movement continues to be frustrated by a politics-driven Internal Revenue Service and the intractability of Obama and Senate Democrats.
But Republicans have a solid chance to win a Senate majority, and Obama approval is stuck in negative territory. Big government liberalism, hailed as the wave of the future in 2009, now seems widely discredited.
The Tea Party obituaries, like Mark Twain's, are premature.
Paul Ryan as Speaker would be good for the country, says … amnesty advocate Luis Gutierrez | Allahpundit
Here we go: Obama "seriously considering" using executive action to expand background checks for private gun sales | Allahpundit


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Sahin, who has just returned to the club from Liverpool, was part of the side humbled 4-1 at home by Hamburg at the weekend.
"It was a very painful defeat because we should not be letting in four goals at home," Sahin told reporters.
"We can make it all good again on Wednesday but we have to be very focused because Shakhtar are a team that will punish us if we make mistakes.
"There has to be a marked improvement in our performance."
More about...
What is your opinion? Feel free to discuss the article under. You have to comment by using your Facebook profile. Be fair and have respect for other people and opinions!
Who of Europe's top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.


text: How to Write a Current Event Paper | Bloglines AnswersHome > Finance > How to Write a Current Event PaperHow to Write a Current Event PaperGlad you asked...The first step in writing a current event paper is to find out as much information as possible on the topic. Then create an introduction and conclusion that will interest the reader.SarahC, Answers Expert| | Similar Questions on Ask.comHow to Write Summaries for Current Events?What Is the Definition of a Current Event?How To Write A Current Event Essay?How To Write A Current Events Summary?How To Write A Current Event Paper?How to Write a Current Event Essay.Popular SearchesSample Current Event PaperExamples of Current Event PapersExample of a Current EventI Need a Current Event for SchoolA Current Event in the NewsWhat Is a Recent Current EventHealth Current Event ArticlesCurrent Event ArticlesCurrent Events for KidsCurrent Event TopicsHome | About | Help | Languages | Services | Privacy Policy | Terms of Service | Contact Us | We're Hiring!Copyright © 2015 IAC Search & Media. All rights reserved.Partner Sites: Citysearch | Merchant Circle | Evite | LendingTree | Match | Pronto | ServiceMagic | Shoes | The Daily Beast | Ask Answers | Life123 | Reference | Thesaurus


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EDMOND — A group of Edmond High School students were making their own sweet music while the Beatles were changing the rock and pop music world in the 1960s.
Edmond musicians grown up and still playing
Bands with aspiring young musicians popped up all over Edmond playing at proms and fraternity parties.
After high school, they all went their own way. They became a college dean, an attorney, a former vice chancellor for academic affairs for the Oklahoma State Regents for Higher Education, a chief executive officer and a mathematician.
Greg Moss, a 1968 graduate, wanted his fellow-high school musicians to play together again at his 40th high school reunion.
The group of old high school friends agreed and the Old Bulldog Band, named after their high school mascot, was created. They took to the stage for the first time with only 10 songs ready to play.
The band, now with more than 100 songs ready to sing, is still together playing at reunions, fundraising events, Grand Lake and the University of Central Oklahoma Jazz Lab.
"When we play we don't take it too serious," said Phil Moss, the band's leader. "We are not Bon Jovi."
They are just a group of men and women who used to hang together in the late 1960s and '70s
"The point is not to look at how good we are," said Phil Moss, 61. "We are reflecting back to high school — recreating a moment, a feeling."
Old Bulldog Band started out playing at one reunion a year. But their popularity took them to three gigs in two weeks this month.
They were back at the class of 1968 reunion. This time it was five year's later and Greg Moss' 45th reunion. They also played for the State Regents at an event put on at the Jazz Lab by UCO President Don Betz. Then there was a cancellation at the Jazz Lab the next day so they agreed to fill in.
Continue reading this story on the...


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What's in a name? Last year, "American Idol" introduced us to Phillip Phillips, and from the moment his name was mentioned for the first time, it seemed as though the crown was his.
On Wednesday's episode of "Idol," which covered the show's San Antonio and Long Beach auditions, viewers were introduced to a few more singers who sounded like winners in name alone: Cristabel Clack, Shubha Vedula and, last but most certainly not least, Papa Peachez.
OK, Papa Peachez is a bit of a cheat, since we're fairly sure that's not the name on his birth certificate. But if there's been a contestant with a better handle in the history of "Idol," we're not recalling.
Peachez — yes, Peachez with a "z" — is a self-described "big black woman trapped in a little boy's body" who hates singing cover songs, so for his audition he sang an original song about, yes, Papa Peachez. "Papa Peachez don't lie," went the tale, as the 19-year-old from Jackson, Mississippi, sang in a deep delta blues bellow. Nicki Minaj was enamored with him from the start. "I think that you are a superstar," she told him. "I loved the song, loved that you wrote it, loved that it was something that only Papa Peachez could sing." (Take just a second and let that last comment sink in. We'll wait.)
The other judges quite weren't as taken with Mr. Peachez, with Keith Urban and Randy Jackson passing on him and Mariah Carey granting him only "a small yes." But that was enough to send it to a tiebreaker, and Minaj passionately argued Peachez' case to Jackson, who was the day's tiebreaking vote. "He's the most special person we've had today!" she pled, and finally Jackson caved. Mr. Peachez is going to Hollywood!
So are Clack and Vedula. Clack, 29, a worship leader from San Antonio, impressed the judges with her version of Alicia Keys' "If I Ain't Got You," which was truly her own version of the song. She used Keys' version merely as a starting point, and added her own runs and inflections to the song. Jackson dubbed her "what the whole thing is about!" and the panel handily sent her through. Vedula, meanwhile, auditioned while only Jackson and Urban were in the room — Carey was caught in traffic, and Minaj was tied up at rehearsals for the American Music Awards — and while they tried to figure out her name ("Chulla Petulla?" Jackson joked. "Petulla Pejulla?") the 17-year-old from Michigan surprised them with a strong version of "Something's Got a Hold On Me." She made it through to Hollywood, and we'll be seeing more from her — and hearing more of that great name, no doubt — in the weeks to come.
Micah Johnson and Matheus Fernandes also made an impression on the episode. Johnson, like Lazaro Arbos earlier this season, has a severe speech impediment, but when he sings it melts away. (Johnson's speech was affected when his nerves were damaged when he was getting his tonsils taken out.) The 24-year-old Navy man's take on Zac Brown Band's "Chicken Fried" earned him four "yes" votes from the judges, and was one of the episode's most well-received auditions.
Meanwhile, Fernandes — who appeared on Oxygen's "The Glee Project" — sang Sam Cooke's "A Change is Gonna Come," lacing it with personal feeling from his own struggle with his height. Carey told him she brought him to tears (but showed no visible evidence of tears, the second time she's pulled that move this season) while Jackson told him his height didn't matter, his talent did. "To me, you 10 feet tall right now," he told the emotional Fernandes as he clutched his golden ticket to Hollywood.
Other standouts on Wednesday's episode include Vincent Powell, Savannah Votion, Ann Difani, Victoria Acosta, Sanni M'Mairura, Adam Sanders, Matt Farmer, Jesaiah Baer, Briana Oakley and Rachel Hale. Thursday's "Idol" — the final audition episode of the season — covers the show's Oklahoma auditions, and then Hollywood Week begins next Wednesday.
What did you think of Wednesday's "Idol" episode? Let us know in the comments!
Get your "Idol" fix on MTV News' "American Idol" page, where you'll find all the latest news, interviews and opinions.


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Giants' trainer says knee swelled after latest workouts
Updated: June 26, 2005, 8:45 PM ETESPN.com news services
Barry Bonds' rehab from knee surgery is in "a holding pattern," said the trainer of the San Francisco Giants on Saturday.
Trainer Stan Conte said that after a period of time in which the swelling in Bonds' right knee had subsided, the swelling increased mid-week following continued workouts.
"Right now we are in a holding pattern," Conte said. "The key is that once we get him into baseball-related activities, he stays in baseball-related activities."
Bonds will ...
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2005 Cadillac STS Repair and Maintenance
A guide to problems, costs, maintenance and repair for your 2005 Cadillac STS
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2005 Cadillac STS Problems
The front turn signal and and daytime running light bulbs are prone to premature failure. Our technicians tell us that these bulbs can be very difficult to replace.
A loose or worn gas cap could be cause the Check Engine Light to illuminate.
Vehicles with certain V6 engines may illuminate the Check Engine Light one or more of the following codes: P0011, P0014, P0021, P0024, P0341, P0346, P0336, or P0391. Our technicians tell us that some vehicles may require a powertrain control module (PCM) software update to correct this issue. Other vehicles may have excess camshaft end play on one or both cylinder heads which will need to be corrected using special procedures outlined by GM.
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2005 Cadillac STS Reviews
my STS is a nice looking car but I have problems after problems one of the air suspension went out cost me 1000 dollar to replace it right now it's making noise. i beleive it's a electrical problems now. I will never buy another cadillac. it doesn't hold its value, The back bumper coming apart. and it hard to find someone to work on them beside the dealers.
i bought this car new and now have 47000 miles and dealer cannt find out why car will not start trouble with fob
I purchased this caddie used with 12,000 miles on it. It now has 26,000 miles and I have not had one problem with this car. Lots of power and handles great. With gas mileage of 23 MPG at 75 MPH on level highway... better than I expected.


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Petstages, Inc. is a designer, manufacturer, and distributor of innovative pet products, providing unique products to address each stage of a pet's life. Based in Northbrook, Illinois, Petstages has assembled a team of premier designers, manufacturers, clinical advisors, and marketers to create and market high quality, safe and durable products for cats and dogs of all ages. Through exceptional packaging Petstages helps educate pet owners on products that provide solutions to meet the needs of both owner and pet. With a commitment to research and development, Petstages provides a wide range of cat and dog developmental toys, and is dedicated to providing a continuous stream of innovative products that address needs of owners and pets.
4" Snuggle Sisal Cat Perch
by PetStages
Cozy Calming Cat Mat
by PetStages


text: This is a character page for Dr. Ashen and related characters.[[WMG: Dr. Stuart Ashen]]* DeadpanSnarker: most definitely.* {{Pyromaniac}}: He burns any blind bag toys that he doesn't like.* SophisticatedAsHell: Does this a lot.* WeaponOfChoice: Hammers and blowtorches. [[WMG: Chef Excellence]]* AdaptationDyeJob: The puppet version has darker hair and skin than the original character seen on the Stay-Fresh bags' packaging. The live-action version of him in ''[[AshensAndTheQuestForTheGameChild The Quest For The Game Child]]'' has lighter skin than the puppet version but still has darker hair than the original.** Fun fact- the puppet appears to be [[http://www.melissaanddoug.com/chef-puppet the Chef puppet made by Melissa & Doug]] and are pretty easy to find for sale if you want one of your own.* BadassMustache: Probably without the "badass" part.* MascotWithAttitude[[WMG: The Silver Skull]]* ArtEvolution: Started out simply as a store-bought costume with a chrome skull mask; starting with ''Quest for the Game Child'', has now become a store-bought costume with a chrome skull mask ''plus a fake mustache''. Could have something to due with his attempts at jazz fusion.* HarmlessVillain: Virtually everything he does is ineffectual.* ThirdPersonPerson[[WMG: Noseybonk]]* JumpScare* KnifeNut* NightmareFace[[WMG: Quincy the Caterpillar Who Sings Obscure Beatles Songs]]* CreepyCentipedes: Averted.* [[spoiler:DroppedABridgeOnHim]]* ExactlyWhatItSaysOnTheTin[[WMG: Interactive ET]]* [[spoiler:BodyHorror]]* CreepyDoll* CreepyMonotone* EldritchAbomination: ''Worse'' than anything Lovecraft could think of.[[WMG: The Godmonster of Indian Flats]][[WMG: Vinnie Vole]]* [[spoiler:DrivenToSuicide]][[WMG: Cydnor 7]]* MachineMonotone-->[[AC:Buy some products. Or. services.]]\\[[spoiler:[[AC:Read. The. [[PrecisionFStrike Fucking]]. Manual.]]]]* PunctuatedForEmphasis[[WMG: The Grass Masks]]* BigBad: Of the 2013 Playmobil advent calendar.[[WMG: Dan Tomlinson]]