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RESEARCH ARTICLEOpen Access
A retrospective case-control study of hepatitis C
virus infection and oral lichen planus in Japan:
association study with mutations in the core and
NS5A region of hepatitis C virus
Yumiko Nagao1*and Michio Sata1,2
Background: The aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese
patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region
and IFN-sensitivity-determining region (ISDR) of nonstructural protein 5A (NS5A) associated with lichen planus.
Methods: In this retrospective study, 59 patients (group 1-A) with oral lichen planus among 226 consecutive patients
who visited our hospital and 85 individuals (group 1-B, controls) with normal oral mucosa were investigated for the
presence of liver disease and HCV infection. Risk factors for the presence of oral lichen planus were assessed by
logistic regression analysis. We compared aa substitutions in the HCV core region (70 and/or 91) and ISDR of NS5A of
12 patients with oral lichen planus (group 2-A) and 7 patients who did not have oral lichen planus (group 2-B)
among patients (high viral loads, genotype 1b) who received interferon (IFN) therapy in group1-A.
Results: The prevalence of anti-HCV and HCV RNA was 67.80% (40/59) and 59.32% (35/59), respectively, in group 1-
A and 31.76% (27/85) and 16.47% (14/85), respectively, in group 1-B. The prevalence of anti-HCV (P < 0.0001) and
HCV RNA (P < 0.0001) in group 1-A was significantly higher than those in group 1-B. According to multivariate
analysis, three factors - positivity for HCV RNA, low albumin level (< 4.0 g/dL), and history of smoking - were
associated with the development of oral lichen planus. The adjusted odds ratios for these three factors were 6.58,
3.53 and 2.58, respectively, and each was statistically significant. No significant differences in viral factors, such as aa
substitutions in the core region and ISDR of NS5A, were detected between the two groups (groups 2-A and -B).
Conclusion: We observed a high prevalence of HCV infection in patients with oral lichen planus. Longstanding
HCV infection, hypoalbuminemia, and smoking were significant risk factors for the presence of oral lichen planus in
patients. It is advisable for Japanese patients with lichen planus to be tested for HCV infection during medical
Hepatitis C virus (HCV) infection is a major public
health problem because it causes chronic hepatitis, cir-
rhosis and hepatocellular carcinoma (HCC). In Japan,
elderly patients are at a higher risk for HCC and hepati-
tis C viral eradication has a smaller effect on hepatocar-
cinogenesis in older patients [1]. In Japan, refractory
cases with genotype 1b and high viral loads are seen in
as many as 70% of chronic hepatitis C patients.
Recent studies have identified both viral and host fac-
tors predictive of the outcome of interferon (IFN) ther-
apy. Among theviral
substitutions in the region amino acids (aa) 2209-2248
(IFN-sensitivity-determining region, ISDR, of nonstruc-
tural protein 5A, NS5A, in HCV genotype 1b) is asso-
ciated with a sustained virological response (SVR) after
IFN treatment of HCV genotype 1b patients [2,3]. In
addition, Akuta et al. reported that aa substitution at
factors, thenumber of
* Correspondence: firstname.lastname@example.com
1Department of Digestive Disease Information & Research, Kurume University
School of Medicine, Kurume, Fukuoka 830-0011, Japan
Full list of author information is available at the end of the article
Nagao and Sata BMC Gastroenterology 2012, 12:31
© 2012 Nagao and Sata; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.
Page 2
position 70 and/or 91 in the HCV core region in
patients infected with HCV genotype 1b are indepen-
dent predictors of SVR and non-virological response
(NVR) [4,5] and also affect hepatocarcinogenesis [6].
HCV mainly affects the liver but there are several
extrahepatic manifestations of chronic HCV infection,
including hematologic diseases such as cryoglobulinemia
and lymphoma, renal disease such as membranoproli-
ferative glomerulonephritis, autoimmune disorders such
as thyroiditis, and dermatologic conditions such as
lichen planus and porphyria cutanea tarda [7-10].
Lichen planus is a chronic inflammatory disease that
affects the skin and oral mucosa. The association of
lichen planus with HCV infection has been reported
widely in the literature [11-16]. In particular, the relation-
ship between lichen planus and HCV has been suggested
by studies from Japan, Italy, Spain, and Brazil, indicating
a strong geographic relationship [11-16]. We first
reported a relationship between HCV and lichen planus
in Japan [12]. Previous reports indicated that there are no
differences in the viral factors such as viral load and gen-
otype between HCV-infected patients with lichen planus
and those without [17,18].
This study was conducted to determine the rate of
HCV infection in individuals with lichen planus, and
with normal oral mucosa as a control group, and to
investigate the impact of aa substitutions in the HCV
core region (70 and/or 91) and ISDR of NS5A among
HCV-infected patients with lichen planus and those
Materials and methods
Group 1 (Patients)
A total of 226 consecutive patients had checkups for oral
mucosal diseases in the Digestive Diseases Center at
Kurume University Hospital Japan from February 2, 2010
to June 28, 2011. In this Digestive Diseases Center, physi-
cians, surgeons, radiologists and an oral surgeon examine
each patient in their own specialized area. An oral surgery
specialist diagnosed 59 of 226 patients with oral lichen pla-
nus clinically and/or histopathologically. These 59 patients
then consulted a liver specialist in the same center for the
presence or absence of liver disease. The 59 patients
(group 1-A) ranged in age from 32 to 87 years, with an
average age of 68.05 ± 9.93 years. There were 14 men and
45 women.
Group 1 (Controls)
We have continued carrying out health screenings of the
residents of X town (adult population: 7,389), in northern
Kyushu, Japan where the prevalence of HCV infection is
the highest in the country [19]. We reported previously
that the residents had a high prevalence of HCV infec-
tion, that HCV infection was the principal cause of liver
disorders, and that extrahepatic manifestations were
strongly associated with HCV infection [19-28].
In the previous study of 509 residents selected ran-
domly, the prevalence of antibodies to HCV (anti-HCV),
HCV RNA, and hepatitis B surface antigen (HBsAg) was
23.6%, 17.9%, and 2.6%, respectively [19]. We conducted
cohort studies from August 1990 to May 2002 on the
long-term prognosis of HCV carriers based on the same
subjects in the town and investigated the risk factors for
deaths due to HCC and liver cirrhosis [24,25].
One hundred and thirty nine subjects who had received
a liver disease examination in 2002 were interviewed in
person by two trained interviewers and all but one of
them were given an oral mucosal examination by an oral
surgeon. We used the headband fiber (50-100-10, Daiichi
Medical Co., Ltd.) that had a brightness of 34,000 luces for
mucosal examination. In this report, we used a control
group consisting of 85 age- and gender- matched indivi-
duals (group 1-B) with normal oral mucosa, selected from
the 139 subjects. The individuals ranged in age from 52 to
90 years, with an average age of 66.35 ± 9.83 years. We
inquired about the following information: present health
condition, medical treatment received in the hospital,
name of the family doctor, the kind of medicine taken,
and the presence of extrahepatic manifestations of HCV
infection such as diabetes mellitus and thyroid dysfunc-
tion. We also asked the family doctors of the subjects
about the presence of extrahepatic manifestations.
Group 2 (Patients)
The subjects were 19 patients with high titers of genotype
1b (over 100 KIU/mL or 5.0 log IU/mL) who were inves-
tigated for aa substitutions in the HCV core region (70
and/or 91) and ISDR of NS5A. These were non-SVR
patients among the 226 patients of group 1 who were not
able to eradicate an HCV during past IFN therapy. We
compared the characteristics of 12 patients who had
lichen planus (group 2-A) and 7 patients who did not
have lichen planus (group 2-B). Group 2 comprised 5
men and 14 women ranging in age from 44 to 73 years
(average 64.47 ± 8.48).
Serological assays
Serum samples from the 144 subjects, including 59
patients with lichen planus and 85 people with normal
oral mucosa, were tested for platelets (PLT) and hemo-
globin (Hb), and for the following liver function tests:
serum alanine aminotransferase (ALT), aspartate amino-
transferase (AST), lactate dehydrogenase (LDH), alkaline
phosphatase (ALP), total bilirubin (T.Bil), total choles-
terol (TC), total protein (TP), and albumin (Alb).
Nagao and Sata BMC Gastroenterology 2012, 12:31
Page 2 of 8
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Evaluation of liver diseases
Anti-HCV was measured using a chemiluminescent
enzyme immunoassay kit (Lumipulse II HCV, Fujirebio,
Tokyo, Japan). HCV RNA in serum was analyzed by the
Amplicor HCV test (Roche, Tokyo, Japan) up to December
6, 2007 and by quantitative PCR assay (COBAS AMPLI-
COR HCV MONITOR v 2.0 Test, COBAS AmpliPrep/
COBAS Taq-Man HCV Test, Roche Molecular Systems,
New Jersey, US) from December 7, 2007 [29,30]. HCV gen-
otype was determined by polymerase chain reaction assay,
using a mixture of primers for the subtype, as reported pre-
viously [31]. HBsAg was assayed using a chemiluminescent
immunoassay kit (Architect, HBsAg QT, Dainabot, Tokyo,
Japan). Ultrasonographic examination was performed on
59 patients and 27 control inhabitants infected with HCV
in order to investigate the shape of the liver and lesions
occupying the liver. Computed tomography and liver
biopsy were performed on some patients. We used other
possible predictors of liver cirrhosis progression, including
serum Alb, T.Bil, prothrombin time, and PLT.
Measurement of body weight
Obesity was defined as a body mass index (BMI) >
25 kg/m2
Detection of amino acid substitutions in the core and
NS5A regions
Detection of aa substitutions in the HCV core region was
performed using the method reported previously [4,5] and
the patients were divided into two groups on the basis of
the findings. Patients with substitution of aa 70 in the core
region of HCV were assigned to the mutant type group
and patients without this substitution were assigned to the
wild type group. The ISDR of NS5A was analyzed using
the method reported previously [3]. Strains with no aa
changes in the ISDR, with 1 to 3 aa changes, and with > 3
aa changes were designated as wild type, intermediate
type, and mutant type, respectively.
Ethics considerations
The study protocol was approved by the Ethics Commit-
tee of Kurume University (reference number: 2134-1) in
accordance with the Declaration of Helsinki. Written
informed consent for participation in the study was
obtained from each patient.
Statistical analysis
All data are expressed as mean ± standard error. Differ-
ences between the two groups were analyzed using the
Mann-Whitney U test, Wilcoxon's test, and the Fisher's
exact test. Differences were judged significant for p <
0.05 (two-tailed). Adjusted odds ratios were calculated
using logistic regression analysis. All statistical analyses
were conducted using JMP Version 6 (SAS Institute,
Cary, NC, USA). The level of statistical significance was
defined as 0.05.
Prevalence of HCV infection among patients with lichen
planus: a retrospective case-control study
We compared the characteristics of group 1-A and group
1-B. The characteristics of the 144 subjects studied are
shown in Table 1. The prevalence of anti-HCV and HCV
RNA was 67.80% (40/59) and 59.32% (35/59), respectively,
in group 1-A and 31.76% (27/85) and 16.47% (14/85),
respectively, in group 1-B. The prevalence of anti-HCV
(P < 0.0001) and HCV RNA (P < 0.0001) in group 1-A
was significantly higher than those in group 1-B.
The prevalence of liver disease (P < 0.0001), thyroid
disease (P = 0.0440) and history of smoking (P =
0.0080) was significantly higher in group 1-A than in
group 1-B (Table 1).
The diagnosis of liver disease in group 1-A included:
past history of HCV infection (n = 1), chronic hepatitis C
(n = 20), chronic hepatitis C during IFN therapy (n = 4),
SVR after IFN therapy (n = 4), chronic hepatitis C with
autoimmune hepatitis (n = 1), chronic hepatitis C with
post-treatment of HCC (n = 2), HCV-related liver cirrho-
sis (n = 2), HCV-related liver cirrhosis with post-treatment
of HCC (n = 6), chronic hepatitis B (n = 1), HBV-related
liver cirrhosis B (n = 1), primary biliary cirrhosis (PBC)
(n = 1), fatty liver (n = 2), and fatty liver with alcoholic
liver disease (n = 1). Those of group 1-B included: past
history of HCV infection (n = 12), chronic hepatitis C (n =
11), SVR after IFN therapy (n = 1), chronic hepatitis C
with post-treatment of HCC (n = 1), HCV-related liver
cirrhosis (n = 1), and HCV-related liver cirrhosis with
post-treatment of HCC (n = 1).
We analyzed the differences between these two groups
in terms of laboratory values for liver function tests and
PLT. As shown in Table 1, abnormal levels of AST (P =
0.0009), ALT (P = 0.0031), Alb (P < 0.0001), T.Bil (P <
0.0001), TC (P = 0.0007), and PLT (P < 0.0001) differed
significantly between the groups.
We examined the viral load in 39 of 40 anti-HCV-
positive patients, excluding one patient who cleared
serum HCV RNA naturally (group 1-A). In seven
patients, including during IFN therapy (4 patients) and
SVR (3 of 4), the viral load was measured before IFN
therapy. The HCV RNA level was high viral load (over
100 KIU/mL or 5.0 log IU/mL) in 32 (82.05%) group 1-
A patients, low viral load (less than 100 KIU/mL or 5.0
log IU/mL) in 3 (7.69%) and unknown in 4 (10.26%). All
HCV RNA-positive individuals among 14 members of
group 1-B had a high viral load. As for an SVR case in
the group 1-B, pretreatment viral load was not clear.
We also examined the HCV genotype of group 1-A; the
genotype was 1b in 27 (77.14%) patients, 2a in two
Nagao and Sata BMC Gastroenterology 2012, 12:31
Page 3 of 8
Page 4
Table 1 Characteristics of study population 1 (n = 144)
CharacteristicsTotal Group1-A Group1-B A vs. B
with lichen
with normal oral
No. subjects14459 85
Sex male/female39/10514/4525/60NS
Age (mean ± SD), years67.05 ± 9.8768.05 ± 9.9366.35 ± 9.83NS
Liver diseasepositive (%)73 50.69%46 77.97%27 31.76%<
Diagnosis of liver
Past history of HCV
13 9.03%1 1.69%12 14.12%
CH-C during IFN4 2.78%4 6.78%0 0.00%
CH-C post IFN (SVR)5 3.47%4 6.78%1 1.18%
CH-C + post HCV-related
3 2.08%2 3.39%1 1.18%
LC-C + post HCV-related
7 4.86%6 10.17%1 1.18%
Fatty liver2 1.39%2 3.39%0 0.00%
Fatty liver + ALD1 0.69%1 1.69%00.00%
Normal liver 71 49.31% 1322.03% 5868.24%
Diabetes mellitus positive (%)149.72%610.17%89.41%NS
Thyroid diseasepositive (%)85.56%610.17%2 2.35%0.0440
Extrahepatic malignant
positive (%)1510.42%58.47%1011.76%NS
Smoking historyyes (%)3725.69%2237.29%1517.65%0.0080
History of alcohol intakeyes (%)5940.97%1932.20%4047.06%NS
Anti-HCVpositive (%)6746.53%4067.80%2731.76%<
HCV RNApositive (%)4934.03%3559.32% 1416.47%<
HCV RNA levelHigh4685.19% 3282.05%1493.33%NS
HCV genotype1b2755.10%2777.14%-
HBsAgpositive (%)32.08%23.39%11.18%NS
AST (U/L) (mean ± SD)29.71 ± 16.8636.09 ± 20.3325.65 ± 12.780.0009
ALT(U/L) (mean ± SD)25.47 ± 20.0630.54 ± 22.3922.25 ± 17.820.0031
LDH(U/L) (mean ± SD)202.40 ±
ALP(U/L) (mean ± SD)272.76 ±
TP(g/dL) (mean ± SD)7.17 ± 0.427.27 ± 0.437.11 ± 0.41NS
Nagao and Sata BMC Gastroenterology 2012, 12:31
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(5.71%), and unknown in 6 (17.14%). The genotype of
group 1-B was not measured.
Multivariate analysis
In multivariable analysis, all variables in the univariable
analyses were included. According to multivariate analy-
sis, three factors, positivity for HCV RNA, low albumin
level (< 4.0 g/dL), and history of smoking, were asso-
ciated with the development of lichen planus. The
adjusted odds ratios for these three factors were 6.58,
3.53 and 2.58, respectively, and each was statistically sig-
nificant (Table 2).
Detection amino acid substitutions in the HCV core
region and ISDR of NS5A among HCV-infected patients
with lichen planus and those without
In the present study, aa substitutions in the core region
(70 and/or 91) and ISRR of NS5A were analyzed by
direct sequencing in 19 HCV-infected patients with
lichen planus and those without [3-5] (Table 3). No sig-
nificant differences were seen between the two groups
(groups 2-A and -B).
In this study, we demonstrated that HCV infection is
significantly associated with the development of lichen
planus. The odds ratio was 6.58 (95% confidence inter-
val 2.89-15.69). This odds ratio was higher than that of
a meta-analysis published recently (odds ratio 2.8) [32].
Hypoalbuminemia and smoking also increased the risk
of lichen planus. However, substitutions of aa 70 and/or
91 and ISDR regions had no impact on the development
of lichen planus.
HCC is one of the most common malignancies, espe-
cially in Japan. The most important risk factors of HCC
are chronic hepatitis C, B and cirrhosis. The effect of Peg-
IFN and ribavirin (RBV) treatment on chronic HCV infec-
tion has been established in several controlled clinical stu-
dies [33]. The effects of IFN are summarized as follows:
elimination of HCV, reduction of hepatic inflammation,
improvement in liver fibrosis, and reduction in hepatocar-
cinogenesis [34]. In Japan, 70% of refractory cases are
infected with genotype 1b with a high HCV RNA load.
Japanese patients with chronic HCV infection are getting
older. Viral mutations leading to aa substitutions in the
HCV core region (70 and/or 91) and ISDR of NS5A have
been shown to be valuable as predictors of virological
response to combination therapy with Peg-IFN and RBV
[2-6]. In addition, single nucleotide polymorphisms (SNPs)
around the human interleukin 28B (IL28B) gene locus
have been reported to affect the efficacy of Peg-IFN and
RBV therapy in chronic hepatitis with HCV genotype 1b
infection [35,36]. In Japan, there is an established standard
therapy for chronic hepatitis C based on guidelines includ-
ing viral factors such as genotype and levels of HCV RNA.
More recently, the effects of variation of IL28B and aa sub-
stitutions in the HCV core region and ISDR of NS5A have
been established.
The association between lichen planus and HCV
infection seems to be more common in individuals liv-
ing in areas of Japan and Italy [11-13]. The difference in
the prevalence HCV-infection in patients with lichen
planus seems to be due to geographic differences in
HCV infection, selection of study subjects such as sex,
average age, and diagnosis in the respective countries,
and some genetic predisposition such as the HLA-DR6
Table 1 Characteristics of study population 1 (n = 144) (Continued)
Alb (g/dL) (mean ± SD)4.15 ± 0.333.99 ± 0.38 4.26 ± 0.25<
T.Bil(mg/dL) (mean ± SD)1.13 ± 5.272.03 ± 8.570.60 ± 0.20<
TC (mg/dL) (mean ± SD)192.34 ±
179.12 ± 37.18 200.12 ± 31.840.0007
Hb (g/dL) (mean ± SD)13.30 ± 1.3913.16 ± 1.3913.39 ± 1.38NS
PLT(/μL) (mean ± SD)18.30 ± 5.57 15.95 ± 6.4219.71 ± 4.48<
HCV, hepatitis C virus; CH-C, chronic hepatitis C; LC-C, liver cirrhosis type C; HCC, hepatocellular carcinoma; CH-B, chronic hepatitis B; LC-B, liver cirrhosis type B;
AIH, autoimmune hepatitis; PBC, primary biliary cirrhosis; ALD, alcoholic liver disease; IFN, interferon; NS, not significant; AST, aspartate aminotransferase; ALT,
alanine aminotransferase; LDH, lactate dehydrogenase; ALP, alkaline phosphatase; TP, total protein; Alb, albumin; T.Bil, total bilirubin; TC, total cholesterol; PLT,
Table 2 Factors associated with lichen planus according to multivariate analysis
Adjusted odds ratio(95% confidence interval) P value
HCV RNA positive
Albumin < 4.0 g/dL
History of smoking (yes)
(2.89 - 15.69)
(1.42 - 9.05)
(1.05 - 6.48)
< 0.0001
Nagao and Sata BMC Gastroenterology 2012, 12:31
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text:
|Reviews for Sick Day
| BlueBear312 chapter 26 . 7/4
Very awesome story
| afterthestorm47 chapter 4 . 6/14
I'm literally going to die from the amount of feels this story gives me...!
| afterthestorm47 chapter 1 . 6/14
Aww...that first chapter was sooooo sweet especially the endiiing! Already can tell I'm going to be in love with this story!
| Guest chapter 10 . 5/2
Ok that's ridiculous. She didn't string him along for years and she didn't parade boyfriends, she had 2 boyfriends, yes and ... ? One episode before Demming Castle was parading Monroe and never showed any interest for Beckett until Demming, and he was with Gina when she was with Josh. I hate when Castle is portrayed as a saint while it's all Beckett's fault, this is far from the case.
| Guest chapter 3 . 5/2
Kate's thoughts in italic are very annoying, and ooc
| jennylovescastle chapter 26 . 3/29
I love the Story. Read it all in all in one Day and loved IT. IT might bei ooc sometimes but hey its fiktion. :) hope to Read more from u
| CKL chapter 26 . 10/28/2014
I adore how much love you were able to give these two characters. I'd like to read more! Great job.
| CharacterDriven chapter 3 . 8/23/2014
oh, Rick-in-a-towel, that is just unfair :-D
| Caskettlover always41319 chapter 26 . 8/10/2014
Okay I know it's been like forever since you updates and stuf and you probably forgot all about this story, but someone suggested this on Tumblr and I just read it and I had to tell you. That was the most amazingly spectacularly perfectly fantabulous story ever. With that story you surpassed J. K. Rowling as my favorite author. That was the most amazing story... I need more words. You are an amazing author and I am determined I read every single other story you've ever written because of this. Goodness gracious. That story made y heart flutter, made me cry, made me laugh. It was just perfect. It was just... Wow. You're amazing.
| Guest chapter 10 . 6/10/2014
'Parading boyfriends' ? Huh ? Not agree at all with this sentence ...
| BigKahuna chapter 18 . 5/28/2014
Nice talk between Alexis and Beckett. Can picture this conversation going the way you have presented it and can visualize one where Alexis rips Beckett a new one before calming down.
| BigKahuna chapter 13 . 5/28/2014
Is this in the Aussie ad campaign for Nuella? If so, us Yanks are missing out!
| BigKahuna chapter 12 . 5/28/2014
Yeah Really do like this story. Dialog very nice, can picture Nathan and Stana talking, which is a problem for some authors. So far just enough smut to be fun without making me cringe.
Thanks for all your effort in putting this together
| BigKahuna chapter 8 . 5/28/2014
Another great chapter. Great way to spend a hot afternoon(er)
| BigKahuna chapter 7 . 5/28/2014
Funny smutty. Just perfect.

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We're kinda of the mindset that it's not terribly hard to carry four glasses and a bottle of wine from the kitchen to the dining room without the help of the MuNiMulA Wine Tray ($98), but that doesn't stop it from being a nifty little... [More]
Aug 1, 2014 8:15 AM
"Quack quack!" Uh, that's the noise a duck makes. "And?" Well, this Swan Watering Can ($14) is a... you know, swan. "I can quack at if I want, though." It'd be more polite to speak its own language. "Okay then, smarty, what sound do swans... [More]
Aug 1, 2014 8:10 AM
Hey, bear. Hey. Hope you're having a good day. Hope you like the new paint job on the front door. Hope you like this Hey Bear Doormat ($29). Oh, you smell the blueberry pie in the oven? Yes, come on in. You can have anything... [More]
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Jul 31, 2014 10:14 AM
Marsupials! They are Australia's most popular export, and for good reason. Crazy things happen when you're separated from the mainland by thousands of miles and millions of years, eh? Crazy things like pouches. And while we'd love to let everyone at this dinner party have... [More]
Jul 31, 2014 10:00 AM
Your guests are going to love this Pressed Flower Love Print ($79) hanging in your sitting room. They're going to be so impressed with your pressed flower skills and illustrated type craftsmanship until they realize that it's just a reproduction. To avoid that inevitable disappointment,... [More]
Jul 31, 2014 9:10 AM
While not as cuddly as your beloved furball, the Meow Art Print ($18-36) does mirror specific parts of a cat's personality and appearance: a little mysterious and aloof, elegant and sleek. Hang this one in a frame above her food and water dish to add... [More]
Jul 31, 2014 8:35 AM
A welcoming addition to your front hall or guest room, this Hey Y'all Gold Foil Print Poster ($23) gives your guests a cheerful greeting as they make themselves feel at home in your humble abode. Let's just hope that they don't feel so welcome that... [More]
Jul 30, 2014 11:00 AM
Right?! It's easy to get caught up in the little details, but when it comes down to it, all we have to remember is to be decent to each other. The rest is just icing on the cake! Be a Nice Human Print ($45) by... [More]
Jul 30, 2014 10:35 AM
It looks like it's a coffee pot straight outta the pages of Alice's Adventures in Wonderland, but this whimsical piece ($35) by XALA is actually a watering can. Will it make weeding and watering your garden an easier task? Not really, but it'll probably make... [More]
Jul 30, 2014 9:10 AM
Bright, bold, big, and durable, this Party Turquoise Indoor-Outdoor Rug ($100, on sale) grabbed our attention from the first moment we spotted it. Of course, the three hundred dollar price slash didn't hurt, either! For a cool hundo, we'll gladly snatch one up and use... [More]
Jul 30, 2014 8:50 AM
It's hard to decide what to do with this brilliant blue Hobnail Pitcher ($78). On one hand, we bet you'd feel a bit of smug satisfaction about your awesome hostessing skills if you were to, say, serve your mother-in-law a glass of ice cold lemonade... [More]
Jul 30, 2014 8:20 AM
You've always thought your fridge could use more flower power. Okay, probably not, but now that you know the Flower Vase & Refrigerator Magnet ($28) exists, the idea to add a few buds to the refrigerator door is a pretty good one, huh? Not convinced?... [More]
Jul 30, 2014 8:04 AM
Place this jar candle ($16) bearing the phrase, "Bad decisions make the best stories" on your entry table. It'll lift your spirits when you walk in the door after a walk of shame, serve as a reminder when you're heading out with the girls on... [More]
Jul 29, 2014 10:39 AM
We may have to start stocking our home bar with Grey Goose, since we have a feeling this Diamond Bottle Stopper ($13) would look pretty ridiculous sticking out of a plastic store brand vodka bottle. Our post-workday cocktail habit is about to get real fancy.... [More]
Jul 29, 2014 10:34 AM
Feeling nostalgic? How about a round of Guess Who? If you're like us, you always wanted to pick Anita or Maria as your "who" of choice, but couldn't because everyone's first question is, "Is it a man or a woman?" Picking a woman meant eliminating... [More]
Jul 29, 2014 10:24 AM
You've made many a gorgeous meal look significantly less attractive after trying to transfer food from the Pyrex you baked it in to a fancier serving dish. Don't make that mistake again. What you really need is a HOT Oven/Serving Bowl ($46) that can cook... [More]
Jul 29, 2014 8:40 AM
This stoneware Mixing Bowl Set ($80) was made in a French factory that's been around for almost 150 years, so we think they know what they're doing when it comes to building sturdy cookware. What we love about these bowls is not only their earthy... [More]
Jul 28, 2014 10:55 AM
This Canvas Throw ($145) is as rough and tumble and sturdy as a burlap bag, but way more comfortable to sit on. You'll plan on keeping this blanket in the trunk to use on the lawn whenever you go to a movie in the park,... [More]
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Outblush is a blog for girls who love to shop. Our staff digs up the best clothes, home stuff, beauty items, and more. New items are posted every day — bookmark us, sign up for email updates, grab our RSS feed, and check out:


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emotion icon bunny
This great custom product in sky blue from our department Women and T-Shirt category can be printed just for you in the size and style you like. The design emotion icon bunny was created by 2014 and uploaded to Spreadshirt for you to have printed on a T-Shirt. Next to a host of other great customized designs, you can find this emotion icon bunny design in Spreadshirt's Satire category. If you are interested in topics like Jänis or bunnies emotion, then you'll love emotion icon bunny designs by 2014. Spreadshirt also offers a huge selection of custom t-shirts, hoodies and accessories for the category Satire as well as top bunny clothing. 2014's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your destination for great designs of all kinds – whether it's Jänis, bunnies emotion or bunny. We are sure that you will find something nice in our shop, there are many amazing custom Satire t-shirts, hoodies, or accessories for you to find! Tags: Design ID: 11962114
Bernie Sanders Silhouette Women's T-Shirts Designed by 5507177
Tammy Comedy Movie Mahalo Bear Shirt Designed by Mackentee
Black Made in North Carolina Kids' Shirts Designed by Citruskids
Key Heart Designed by Kinnydesigns
Nah Rosa Parks Quote T-Shirts Designed by The Shirt Yurt
Beast Jacket Shirt Designed by Winterwolfjon
Hoodini Vanoss Gaming T-Shirts Designed by 3982143
Skeleton X-ray Maternity Shirt Designed by gladditudes
This figure-flattering, slim fit t-shirt is soft, stylish and above all comfortable. This is the one you don't let your girlfriends borrow, because you'll never see it again. It's perfect with jeans, khakis, leggings or pretty much any other bottom and it's great for layering.
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browse markets
help your farmers' market win
contest updates
rules & prizes
Love Your Farmer's Market Contest
14 votes
Keene Farmers Market
Keene, NH
more about Keene Farmers Market
top recruiters for
Keene Farmers Market
2294 days, 14 hours ago
Local food helps the environment and our local economy!
most recent votes for
Keene Farmers Market
2241 days, 8 hours ago
Kimberly Shaw
2255 days, 12 hours ago
Best place for fresh and also organic produce and assorted items every Tuesday and Saturday in this area.
Lora Fleming
2294 days, 12 hours ago
locally grown!!!!!!!!!!!
Shawn Lantry
2294 days, 14 hours ago
2294 days, 14 hours ago
Local food helps the environment and our local economy!
2297 days, 15 hours ago
2299 days, 6 hours ago
It's the best show in town! Fresh, friendly, local, intimate, organic. . .
Val Ricardi
2299 days, 14 hours ago
I love the fresh produce as well as the idea that I am supporting local farmers!
Luke Bergeron
2299 days, 16 hours ago
Fresh, locally grown produce tastes better, is better for you, and is a great way to give back to the community. The growers are friendly, and it's a good way to meet new people and talk about different ideas of growing fruits, flowers, and vegetables. You can get fresh meat and dairy products as well, and everything just tastes so much better being that close to home.
Deb Dunham
2300 days, 2 hours ago
I believe we should support our local farmers or someday we will have no where to get the food we need
view all 14 votes
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Government-Sponsored Enterprises:
System of Internal Controls at Freddie Mac, Fannie Mae, and Sallie Mae
GGD-92-50: Published: Mar 31, 1992. Publicly Released: Mar 31, 1992.
Additional Materials:
- Full Report:
(202) 512-4800
Pursuant to a legislative requirement, GAO reviewed internal control structures at the Federal Home Loan Mortgage Corporation (Freddie Mac), the Federal National Mortgage Association (Fannie Mae), and the Student Loan Marketing Association (Sallie Mae).
GAO found that: (1) audits and examinations by internal and external auditors at Freddie Mac, Fannie Mae, and Sallie Mae uncovered no significant weaknesses in government sponsored enterprise (GSE) activities, except for Freddie Mac controls over its multifamily loans; (2) some of the data on delinquent loans reported to Freddie Mac through its automated systems appeared to be unreliable; (3) Freddie Mac control over purchasing and servicing multifamily loans were not appropriately designed or implemented; (4) asset acquisition and quality control tests over business partners uncovered no significant additional weaknesses in GSE operations; (5) as a result of such weaknesses, Freddie Mac charged off over $300 million against reserves from 1986 through 1990, made senior level personnel changes, suspended buying new multifamily loans in October 1990, and made or planned several changes in its purchasing, servicing, and monitoring of multifamily loans; and (6) Freddie Mac does not plan to resume purchasing new multifamily loans until sometime in 1992.
Jul 30, 2015
Credit Rating Analysts:Views Varied on Merits of a Professional Organization, but Creating One Now Viewed as PrematureGAO-15-591: Published: Jul 30, 2015. Publicly Released: Jul 30, 2015.
Jul 27, 2015
International Insurance Capital Standards:Collaboration among U.S. Stakeholders Has Improved but Could Be EnhancedGAO-15-534: Published: Jun 25, 2015. Publicly Released: Jul 27, 2015.
Jun 25, 2015
Bank Regulation:Lessons Learned and a Framework for Monitoring Emerging Risks and Regulatory ResponseGAO-15-365: Published: Jun 25, 2015. Publicly Released: Jun 25, 2015.
Jun 11, 2015
Federal Home Loan Banks:Information on Governance Changes, Board Diversity, and Community LendingGAO-15-435: Published: May 12, 2015. Publicly Released: Jun 11, 2015.
May 22, 2015
Federal Home Loan Banks:Collateral Requirements Discourage Some Community Development Financial Institutions from Seeking MembershipGAO-15-352: Published: Apr 23, 2015. Publicly Released: May 22, 2015.
May 5, 2015
Community Development Capital Initiative:Status of the Program Investments and ParticipantsGAO-15-542: Published: May 5, 2015. Publicly Released: May 5, 2015.
Apr 30, 2015
Securities Regulation:SEC Can Further Enhance Its Oversight Program of FINRAGAO-15-376: Published: Apr 30, 2015. Publicly Released: Apr 30, 2015.
Apr 15, 2015
Export-Import Bank:Status of Actions to Address GAO Recommendations since the Bank's 2012 ReauthorizationGAO-15-557T: Published: Apr 15, 2015. Publicly Released: Apr 15, 2015.
Apr 6, 2015
Management Report:Areas for Improvement in the Federal Reserve Banks' Information Systems ControlsGAO-15-413R: Published: Apr 6, 2015. Publicly Released: Apr 6, 2015.
Mar 19, 2015
Financial Company Bankruptcies:Information on Legislative Proposals and International CoordinationGAO-15-299: Published: Mar 19, 2015. Publicly Released: Mar 19, 2015.
Looking for more? Browse all our products here


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If figures being reported are correct then the iPad has already sold over 90,000 units in its first day of pre-orders. Fortune's Phillip Elmer-DeWitt announced that "51,000 orders in two hours" had been completed shortly after noon on the first day. Many high profile bloggers have been reporting on their order details and Andrew Erlichson wrote "We just bought two … Read More
Order Your iPad Today. Last Minute iPad Specification Updates
When Apple announced the iPad in January some people who were lucky enough to get some hands on time noted with some disappointment that there was no way to lock the screen orientation. This can sometimes be annoying on an iPhone and consequently some third party apps provide it as an option. On a larger device like the iPad it … Read More
Rick Sammon's 24/7 Photo Buffet: An almost picture perfect application
Rick Sammon's 24/7 Photo Buffet [rating: 4/5] Don't get me wrong, I like to take a picture as much as the next person, as long as the next person is someone who is not too bothered about it! But after just a few moments looking through Rick Sammon's 24/7 Photo Buffet I was already inspired to go out and try … Read More
Palm Announces 20 New Game Titles at GDC 2010
Although Palm were hopelessly slow at getting a decent high-performance 3D API into the hands of it's developers, it seems to have stepped up it's efforts in the last couple of months with the help of some "early-access" developers. Earlier this week we reported that Palm had announced a public beta version of the Palm® webOS™ Plug-in Development Kit (PDK) … Read More
Microsoft unveils first 3D games for Windows Phone 7 Series. Direct3D only!
Microsoft has today released some screenshots of a couple of 3D games that are currently in development for the Windows Phone 7 Series. Is it just me or is that an awfully big mouthful for such a small device? Anyway, the images look interesting, but this is not an impressive enough couple of titles to excite people into buying another … Read More
Ngmoco Gives Interesting Talk on How Eliminate Was Built | GDC 2010
In one of the first GDC (Game Developers Conference) panels this morning in San Francisco Ngmoco kicked things off with a presentation on how they put their flagship "freemium" FPS Eliminate together. Their aim from the outset was to produce the definitive iPhone FPS which boasts all the features gamers expect from a console or PC equivalent. With a small … Read More
Phone Patent Battle lines drawn. Microsoft eyes opportunities.
As I suggested last week, Apple's lawsuit against HTC over phone patents did not come out of the blue, and is not the last of what may mushroom into a multi-company skirmish, perhaps even including Microsoft. Oppenheimer analyst Yai Reiner issued a report yesterday that illuminated the issues and industry discussions that have been going on behind closed doors prior … Read More
Unity releases Unity Engine 3.0 which adds support for the iPad
Unity Technologies has announced that it's released a new version of the Unity Engine (version 3.0) which adds in support for the iPad, Android and PlayStation 3, giving it the "broadest support on the market," according to a statement. Unity already had support for iPhone and iPod Touch, so this is a welcome but not unexpected move from them. With … Read More
Apple appears to be making more moves to "tidy" the App Store.
We reported last week about Apple removing the vast majority of apps from iTunes that they considered contained too much "adult orientated" material. Over the weekend we also took a look at how Apple were removing some WiFi Signal Finder apps from iTunes (otherwise known as "Stumblers"). This second case was clearly to do with those apps using Private Frameworks. … Read More
FetchUp Review: A fun game that falls one fruit short of a fruit basket
FetchUp [rating: 3.5/5] I'm not sure whether FetchUp is purposely trying to jump on the 'green' bandwagon but with it's story of an alien need to collect bio fuel to enable him to return home it could gain some extra fans with it's green credentials. FetchUp is a fruit collecting arcade game where you control an alien by tilting your … Read More
Kill the Fly Review: Killing fly's have never been such fun
Kill the Fly [rating: 4/5] I'm not sure that this game really needs a disclaimer but I can imagine that some will shy away from this title not only at the thought of having to kill hundreds if not thousands of fly's but also due to the constant references to the stuff that fly's often like to fly around. However … Read More
New 3D Games Potentially Coming To The Palm Pre and Pixi
The biggest barrier for good quality high-performance 3D games on Palm Smart-phones has finally been removed. Palm (PALM) have finally officially confirmed that they have added a component to their webOS Software Development Kit which will allow developers to target high-performance 3D graphics and native ARM code. This is in the form of a webOS plugin that Palm plans to … Read More
Microsoft's Courier. Is this the iPad slayer?
Microsoft's Courier tablet was first mentioned on tech sites a couple of months ago. At the time it was only a concept which existed in the form of a kind of User Interface showcase with cartoon hands controlling a virtual device. But those concept videos were rather impressive and very forward thinking. Of the many UI features that impressed me … Read More
Apple removes Wi-Fi finders from the App Store. Some fear another purge!
It seems Apple may be starting another round of application removals from the App Store. On Thursday it started removing selected Wi-Fi finder apps, otherwise known as "stumblers". These apps enable iPhone and iPod Touch users to locate Wi-Fi networks around them and then try to use those networks for internet access. One reason given by Apple to one app author was … Read More
Top Apple News Stories: Apple v HTC, Macintosh Developer License, iPad Launch and More
It's been a busy week for Apple… Apple shares hit another high today at the end of a week where the computer company (which is now predominantly by it's own COO's admission a mobile device company) launched it's first thinly veiled attack on it's old bedfellow Google, dropped the entry price for developers to it's desktop developer license, officially announced … Read More


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Cruisin' with Lincoln on 66 Visitors Center
Located in the heart of Downtown Bloomington on Historic Route 66, the Cruisin with Lincoln on 66 Visitor Center exhibits cover stories about dining, lodging and travel, which were experienced by both Abraham Lincoln and Route 66 travelers. These are supplemented by local items, books, cards, maps and more!
Scarecrow Fest at Route 66 Park in Braidwood
Check out the 3rd Annual Scarecrow Fest with live music, chili cookoff, and pumpkin decorating for the kids. Participants enter a scarecrow for judging. Top three winners receive a gift card to a local business.
Route 66 Arcade Museum
The Rt. 66 Arcade Museum is chock full of vintage pinball and video games from the 1930s-1970s - most of which can be played. It's the perfect place to misspend your youth all over again, one quarter at a time!
Museum of the Gilding Arts
The Museum of the Gilding Arts' focus is the history, craft, and use of gold and silver leafing in architecture and in decoration throughout history. The exhibit features items from the Society of Gilders' Swift Collection. The M. Swift & Sons company manufactured gold leaf in Hartford, CT, and began its operations in 1887. Free Admission - Donation Only
Route 66 Half-Marathon
Race down memory lane during this one of a kind Route 66 Half Marathon hosted by the City of Litchfield and RaceMaker Productions. If a half marathon is too much for you, do not worry, we have a race for everyone. Try running the 5K or Mile Dash.
Edinger's Filling Station
Edinger's Filling Station is a casual dining restaurant in downtown Pontiac. Open for lunch and breakfast, the Edingers pride themselves on serving delicious, homemade food in an inviting atmosphere with friendly service.
Pontiac Cruise Night
Bring your antique, classic, or new car to downtown Pontiac and enjoy the fellowship of hundreds of other automobile enthusiasts. The small registration fee is used to support local charities.
Atlanta Museum
Exhibits focused on Abraham Lincoln, Route 66, and other aspects of Atlanta's history are featured. The Museum's Local History Resource Center provides extensive genealogy materials accessible to the public. Housed in a beautifully restored 1867 building, the Atlanta Museum presents both permanent and new, rotating exhibits. Open Monday through Saturday 9 a.m. to 4:30 p.m. Closed Sundays.
William Tell Restaurant
William Tell has been a landmark for legendary fine dining in Chicago since 1952. Our elegant dining room embodies old world charm, while our menu reflects a distinct European style. Located on the Historic Route 66.
Route 66 Memories Museum
Stop by this eclectic museum to explore the history of Route 66, car culture and local history. There is even a Rolls-Royce on display! The collection was brought together by a local historian with great stories to share. Located just a few doors from the Palm's Grill this museum is a must see.
Lake Lou Yaeger
Lake Lou Yaeger, this 1400+ acre lake offers 45 miles of beautiful shoreline and several recreational opportunities. Visitors can enjoy boating, skiing, swimming, fishing, and camping. The 300 acre park has five picnic areas, two playgrounds, pavilions, grills, restrooms, and hiking trails. With miles of horse trails and a new equestrian campground with full hook-ups and shower house, Lake Lou is a great destination for horse enthusiasts. Milnot Beach has two diving platforms, showers, snack bar, and lifeguards on duty.
The Colaw Rooming House
Return to Rt. 66, circa 1947, when you overnight at The Colaw Rooming House. Where you'll experience travel on the Mother Road before Interstates and motel chains were the norm. Located just 2 blocks from Rt. 66 in quaint Atlanta, Illinois, The Colaw Rooming House offers three bedrooms, two full baths, a charming living room with fireplace, dinning room, curved front porch, and delightful yellow and red 1940's kitchen. To further enhance your step back in time, your stay includes a complimentary breakfast at The Palms Grill Cafe-Atlanta's fully restored, circa 1935 small town diner. For more information please visit our website www.thecolawhouse.com
Downtown Bloomington Farmers Market
The Market is open from 7:30 a.m. to noon every Saturday morning from May through October. Located on the historic downtown square, the Farmers' Market is managed by the Downtown Bloomington Association. Not only does the market give customers a colorful venue to buy locally grown farm products, it also puts them in touch with local artisans of prepared goods and fine arts, musicians, and community organizations. The Downtown Bloomington Association Farmers' Market is a producer-only market offering a wide array of farm products — including vegetables, fruits, cheeses, pork, beef, free-range poultry and eggs, flowers, plants, herbs, and more grown and produced by the individual selling these items! The market features different musical performances each week. Cooking demos are offered regularly, and the Kids' Zone has sponsors that offer weekly hands-on activities for all ages.
Prairie View RV Park
Small campground located in a country setting near Chicagoland Speedway, Historic Route 66 and a 25 mile hiking/bike trail. Business hours are 8:00am - 1:00pm.
Berwyn Route 66 Wayside Exhibits
The City of Berwyn has placed four exhibits on Ogden Avenue to educate travelers, tourists, and residents about Berwyn's heritage as one of the first eastern suburban communities along Historic Route 66. Berwyn's four exhibits feature the origin of the Ogden corridor and its early history, its first auto-oriented "fast food" restaurants, and its automobile-based economy and car culture. Visit our Information Kiosk for more information!
Clocktower in Atlanta
Located next to the Atlanta Public Library and Museum the clock tower was added in the 70s. The clock itself is the original 1909 hand-would clock from the Atlanta High School.
Sky View Drive In - Litchfield
The Sky View Drive-In Theatre in Litchfield opened in the Spring of 1950 and has been in operation each season since then. We are a seasonal operation and run from the first or second weekend in April until the end of September. Open on Fridays, Saturdays, and Sundays only.
Atlanta Public Library and Museum
Located across from Route 66 Park in historic downtown Atlanta, Illinois, the Atlanta Public Library is a hub of community activity and an attraction for tourists who are making the Route 66 pilgrimage. Throughout the year, the Library offers a wide range of programs for children, teens and adults. From reading, arts, and crafts activities for children to outdoor family programming, adult book clubs, writing workshops, programs for seniors, informational programs, and special events, the Library has something for everyone. Built in 1908, this octagon-shaped building is one of the few of its kind in the state. The museum in the basement of the library houses pieces of local history. The library and museum are both on the National Register of Historic Places.
Berwyn Route 66 Museum
Boasting an eclectic collection of Route 66 artifacts, aerial photos and historic signs, the RT 66 Museum is a great beginning for your journey. Open weekdays 9am to 5pm. No charge for admission.
Sprague's Super Service in Normal
A Tudor revival building constructed in 1931 by William Sprague to house a service station, restaurant and garage, it is the largest of three remaining two-story fuel station buildings on US 66, originally housing a café and service station on the main floor plus two second-floor apartments for the owner and the station attendant.
J.H. Hawes Elevator
In the heart of our nation's cornbelt, just a block off Historic Rt. 66, you can discover your connection to Illinois' rich grain producing, storing, and shipping history by visiting the J. H. Hawes Grain Elevator Museum.
Ambler's Texaco Station in Dwight
This circa 1940s Texaco station was once a thriving service station but now serves as a Route 66 welcome center. The station is listed on the National Register of Historice Places and has been awarded fundng through the Route 66 Corridor Preservation Program to be restored to look like it did in the 1940s.
Smiling Water Tower
This colorful watertower is found in the small town of Atlanta, IL
Standard Filling Station in Odell
Although Odell's Standard Oil Gas Station no longer sells gasoline, it has become a welcome center for the Village of Odell. Owned by the Village of Odell, the station is open daily 11:00am to 3:00pm for tours and as a visitor center.


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Learners will record detailed observations of a simulated surface and core sample of Mars, analyze a simulated surface and core sample of Mars, compare and contrast an unknown foreign object with the surface and interior of Mars, and learn... (View More) preliminary facts about Mars, its surface, and its place in the Solar System. The lesson uses the 5E instructional model and includes: TEKS Details (Texas Standards alignment), Essential Question, Science Notebook, Vocabulary Definitions for Students, Vocabulary Definitions for Teachers, three Vocabulary Cards, and a Mini-Lesson. This is lesson 2 of the Mars Rover Celebration Unit, a six week long curriculum. (View Less)
Materials Cost: Free
This is a demonstration about the density of the planets. Learners will compare the relative sizes and masses of scale models of the planets as represented by fruits and other foods. They will then dunk the "planets" in water to highlight the fact... (View More) that even a large, massive planet - such as Saturn - can have low density. They discuss how a planet's density is related to whether it is mainly made up of rock or gas. This activity is part of Explore! Jupiter's Family Secrets, a series designed to engage children in space and planetary science in libraries and informal learning environments. (View Less)
Materials Cost: $5 - $10 per group of students
Learners will model the gravitational fields of planets on a flexible surface. Children place and move balls of different sizes and densities on a plastic sheet to develop a mental picture of how the mass of an object influences how much effect it... (View More) has on the surrounding space. This activity is part of Explore! Jupiter's Family Secrets, a series designed to engage children in space and planetary science in libraries and informal learning environments. (View Less)
Materials Cost: $5 - $10 per group of students
The 9-session NASA Family Science Night program invites middle school children and their families to discover the wide variety of science, technology, engineering, and mathematics being performed at NASA and in everyday life. Family Science Night... (View More) programs explore various themes on the Sun, the Moon, the Stars, and the Universe through fun, hands-on activities, including at-home experiments. Information about Family Science Night implementation and support resources, including the facilitator's guide, are available by registering on the Family Science Night Facilitators website (see Related & Supplemental Resources for link). (View Less)
Learners will read about Mars and then examine an unknown sample (such as a sandwich or "fun size" chocolate bar) to determine if the sample could have come from Mars. The lesson uses the 5E instructional model and includes: TEKS Details (Texas... (View More) Standards alignment), Essential Question, Science Notebook, Vocabulary Definitions for Students, Vocabulary Definitions for Teachers, three Vocabulary Cards, and a Mini-Lesson. This is lesson 2 of the Mars Rover Celebration Unit, a six week long curriculum. (View Less)
Materials Cost: $1 - $5 per group of students
This is an activity about impact craters. Learners will experiment to create impact craters and examine the associated features. Then they observe images of lunar craters and explore how the mass, shape, velocity, and angle of impactors affects the... (View More) size and shape of the crater. This activity is part of Explore! To the Moon and Beyond! - a resource developed specifically for use in libraries. (View Less)
Materials Cost: 1 cent - $1 per group of students
This is an activity about the states of matter. Learners will participate in a demonstration to reintroduce them to three states of matter: solid, liquid, and gas. The demonstration also introduces them to a fourth state of matter, plasma, through... (View More) investigation of the properties of volume and shape as they relate to common solids, liquids, and gases, and to the mystery matter later identified at the end as plasma. The demonstration also covers plasma's connection to the Sun and connections to science related to the Interstellar Boundary Explorer, or IBEX, spacecraft. This activity complements other IBEX informal education materials. The demonstration requires use of a small plasma ball and, ideally, a slightly darkened room so that the plasma ball can be more easily seen. An instructional video explaining how to facilitate this activity is available: http://bit.ly/125ZW5k. (View Less)
Materials Cost: Over $20
This is a lesson which gives students the opportunity to imagine they are scientists, provides them with a basic understanding of aurora and helps them to use creative methods in their observations. First, students will study the scientific aspect... (View More) of the aurora. They will also look at images of the aurora (both pictures and illustrations) and describe what they think of when they see them. These descriptions can be stored in the student portfolios as they will be useful in future lessons. Includes teacher notes and instructions, student workshops and an online, animated story, and related teacher resources on aurora. This is lesson three of a collection of five activities that can be used individually or as a sequence; concludes with a KWL (Know/Want-to-know/Learned) assessment activity. (View Less)
This collection of activities presents learners with intriguing questions about the universe and provides an opportunity to explore topics related to the search for life beyond our own planet. The collection includes eight existing classroom... (View More) activities that have been adapted for after school school settings. Each activity can be completed in one hour, however some activities require advance preparation. The activities also require materials that may need to be gathered by the instructor. However, these include commonly available supplies. The activities in this collection are targeted for 5-12 year olds. Separate instructions for the different age groups are provided as appropriate. (View Less)
Materials Cost: 1 cent - $1 per group of students
This interactive adventure engages children in a story-based scenario that emphasizes concepts of remote sensing and how NASA scientists use satellite imagery to better understand the Earth's environmental changes. The story features a pigeon named... (View More) Amelia and is set in New York City. Amelia's owner, a young girl named Maria, receives a gift from her grandfather-a camera specially designed for strapping on to a pigeon along with copies of old photographs taken of New York City landmarks. Suddenly, Amelia's flights around the city take on new relevance; she visits the Bronx Zoo, Central Park and Battery Park to take updated pictures of those same landmarks from her "birds-eye" perspective. Through Amelia's adventures, and with some help from a NASA scientist, Maria learns about the history of aerial images, the use of images to detect changes over time, the significance of color, texture and shape in interpreting those images, and the importance of images taken from today's NASA satellites to our understanding of Earth. The story is set in New York City, chosen for its size, diversity and the visibility of prominent features in satellite imagery. (View Less)


text: http://stackoverflow.com – I have successfully installed SymmetricDS on CentOS 6.3 64 bits. I can launch it : ../bin/sym --port 8080 --server Now I am trying to launch it as a service. I followed the instructions of : http://www.symmetricds.org/doc/3.2/html/advanced-topics.html#running-ser... The command /etc/init.d/sym_service status returns SymmetricDS is not running. When I issue : /etc/init.d/sym_service start I get Starting SymmetricDS/etc/init.d/sym_service: /opt/symmetric-ds/bin/sym_service: /lib/ld-linux.so.2: bad ELF interpreter: No such file or directory Any clues ? (HowTos)


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Physical Techniques in the Study of Art, Archaeology and Cultural Heritage
Series Editor:
- David Bradley, BSc (Hons) (Essex), MSc (Radiation Physics) (London), PhD (USM) CPhys, FInstP, FIPEM, FIFM, Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, UK
- Dudley Creagh, BSc (1 Hons) Dip Ed (Qld) MSc (UNE) MSc (Brist) PhD (NSW) CPhys CEng FInstP FAIP, University of Canberra, Division of Health Design and Science, Canberra, Australia
The first of its kind, this series is devoted to the use of physical principles in the study and scientific conservation of objects with cultural heritage significance. It begins with a review of the modern museum, which discusses new techniques employed in the conservation of museum artifacts such as X-ray tomography and other techniques used to study Egyptian mummies, bones and mineralization of bones in the archaeological context, and the degradation of parchment. All of these topics and techniques are essential for the preservation of our history. This includes finding ways to preserve parchment documents and letters, which much of our written heritage is documented on, so that it can be used and understood for generations to come.View full description
This book is a must have for any museum as well as any university that teaches or employs the techniques discussed.
Museum conservators, curators, managers and museologists. Also of use by university science departments, university postgraduate students and university libraries.
Book information
- Published: May 2006
- Imprint: ELSEVIER


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Tag Archives: jazz
The Leg-Hold Turn
Prepare in a wide fourth-position plié. Battement your leg forward toward your face—keeping it perfectly straight, with your foot … More »
Posted in How To, Jazz Tagged jazz, Leg-Hold Turn, Move, Trick Leave a comment
The Layout
JAKOB SAYS: "The key to the perfect layout is timing. Your head and leg need to hit the final position … More »
Posted in How To, Jazz Tagged Jakob Karr, jazz, Layout, Tricks Leave a comment
Taking Times Square
Posted in Fashion, Get The Look Tagged Broadway, dancewear, fashion, jazz, Motown the Musical, musical theater, NYC, Sasha Hutchings Leave a comment
Video Contest-A-Palooza
All my dance nerds: Get thee to dancemedia.com right now, because there are two pretty great video contests currently underway! … More »
Taking the Leap
Few things wow an audience like an explosive side leap. But before you bust out this move in your next … More »
Wanna Win a Summer Intensive Scholarship?
Of course you do! DanceMedia has teamed up with NYC's Joffrey Ballet School to offer a contest with pretty sweet … More »
Posted in MARGARET'S MUSINGS Tagged Ballet, dance, DanceMedia, jazz, Joffrey Ballet School, Summer Intensives 3 Comments


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Around the clock
Monday 17 August
As North Korea assumes a new time zone, Matt Alagiah asks whether the 30-minute alteration will make a difference – and what it really means.
Anywhere else and this would have read like an April Fools' joke. But this was North Korea. This Saturday the insular kingdom put its clocks back half an hour, returning the country to pre-colonial Korea Standard Time and…


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Mt. Pisgah DinerMarch 2, 2012Diner • Winchester, United States
Try Joni's famous patty-melt!!!
The staff love high-fives! They're free too! Woo!
Wanna put the map pin in the right place?
DJ'd a beautiful wedding reception last night. Now enjoying great food, wine, and company at the inn. New World Landing is a perfect spot for locals and tourists looking for food, drink, and a room!


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EAN-codes: 4002921013196
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Bilora FB3-O1 wireless remote release for Olympus saved
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Currently viewing the tag: "financial"
New York City Councilman Mark Levine Proposes Accepting Bitcoin for Fines and Fees
On February 16, 2015 By Chris Martucci February 16, 2015
Councilman Mark Levine (D-Manhattan) is introducing a bill that would allow New York City to accept the digital currency Bitcoin as payment for fines and fees, including parking tickets and court fees.
Levine expressed several justifications for the bill, citing its popularity among young, tech-savvy individuals. "Today you can buy almost anything [...]Continue Reading →
Microsoft Takes a Tentative Step Towards Innovation with Limited Bitcoin Adoption
On December 22, 2014 By Neil Issar December 22, 2014
Microsoft recently announced that it would allow its digital content to be purchased with bitcoins. The change is limited in that it only opens Microsoft's Windows, Windows Phone, and Xbox platforms to the new payment method, there is a daily exchange cap, and only US-based customers can make bitcoin payments. This means that Microsoft [...]Continue Reading →
Bitcoin Education Day on Capitol Hill
On September 5, 2014 By Brenan Salgado September 5, 2014
The newly-enacted Chamber of Digital Commerce (CDC), a bitcoin lobbying group, brought more than thirty professionals from the bitcoin industry to Capitol Hill on August 29 in an effort to spread awareness about the digital currency.
The CDC's goal is to provide information to lawmakers and the general public about the bitcoin technology in [...]Continue Reading →
Halliburton II: Rethinking Fraud on the High-Frequency Market
On July 9, 2014 By Richard Saunders July 9, 2014
On June 23th, the Supreme Court handed down one of the most highly anticipated securities litigation opinions in recent memory. Halliburton II brought the fraud-on-the-market theory, the linchpin of securities class actions, squarely in front of the Court. For months, excerpts from various other Court opinions suggested the theory was ripe [...]Continue Reading →
He's Back!
On March 14, 2014 By Richard Saunders March 14, 2014
It appears no one is safe from Carl Icahn, not even Silicon Valley.
The infamous activist investor is at it again, and this time eBay is the object of his disaffection. In what has become a very public battle over recent weeks, Icahn has described eBay's Chief Executive, John Donahoe, as [...]Continue Reading →
Bottom of the Pyramid
On February 18, 2014 By Chastity Bobo January 14, 2015
A few weeks ago, the cheerleaders for the Oakland Raiders (known as the Raiderettes) sued the Raiders franchise for illegal payment practices. The allegations include withholding all pay until after the end of the season, only being paid for a portion of hours worked, and forcing the cheerleaders to pay many of their [...]Continue Reading →
Supreme Court Takes on Software Patent Eligibility
On December 6, 2013 By Bradlee Edmondson January 29, 2014
Alice Corp. Pty. Ltd. v. CLS Bank International
In 2005, the Australian company Alice Corp. Pty. Ltd. filed a patent application with the US Patent and Trademark Office for a method of reducing financial risk by ensuring, through "data processing systems" and third-party exchanges, that counterparties make good on their obligations. In 2010, [...]Continue Reading →
Friday Morning JETLawg — Good Luck in Fall 2013 Exams
On November 22, 2013 By Bradlee Edmondson January 26, 2014
Thanks to our authors for a great semester full of legal analysis across intellectual property, entertainment, and technology law. This will be our last regularly scheduled post of the semester. We head into final exams right after the Thanksgiving break. Good luck, everyone!
Google announces that it will Continue Reading →
Shares of Arian Foster? Not Quite.
On October 22, 2013 By Emily Gabranski October 21, 2013
This week Fantex announced the newest public investment option made possible by the JOBS Act of 2012 [PDF]: stock in professional athletes. Arian Foster of the Houston Texans will be the first athlete to sell shares of his future earnings to the public. According to the Prospectus filed with the SEC [...]Continue Reading →
Kickstart My Art
On September 17, 2013 By Jeffrey W. Sheehan January 14, 2015
This summer, Martha Ingram saved Nashville's Schermerhorn Symphony Center from a looming bankruptcy. Now, the symphony that calls the Schermerhorn home is seeking out a new patron to "be a part of the experience" of recording three works by composer Joan Tower. You are that patron. The Symphony is one of [...]Continue Reading →
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I wrote an answer yesterday to this: http://stackoverflow.com/questions/192479/whats-the-coolest-hack-youve-seen-or-done and I was trying really hard to remember my 6502 assembly, and I couldn't for the life of me remember how to branch if less than...
lda $C010
cmp #$80
bcc :1 ; branch if less than? I forget how to do that.
lda $C000
jsr $FDF0 ;output the accumulator value to the screen
Anybody know what the instruction is? BNE and BEQ are equals, BCC was for carry, and a CMP is basically an SBC and that affects the carry, but I'm not sure if it works in that case.


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Energy & Renewables Companies in Qatar
Category: Energy & Renewables ×
Employees number: 11-100 ×
Industry: Leather & Tanning ×
Location: Asia & Middle East ×
Location: Qatar ×
Magna Energy & Hydro Systems Pvt. Ltd.
based in West Mambalam, INDIA
Magna Energy is one of the nation's leading manufacturers of Hydrojet High pressure water jetting pumps. We specialize in various Equipments for Power and Process industries. Magna Energy and Hydro Systems Pvt Ltd has two divisions one for Energy and other for Hydro. By viewing our web site you will get a comprehensive solution for your power and pump needs. We are the ...
Anguil Environmental Systems, Inc.
based in Milwaukee, WISCONSIN (USA)
Anguil Environmental Systems is a global provider of industrial air pollution control, emission abatement and energy recovery systems. We design, manufacturer, service and install thermal and catalytic oxidation technologies as well as heat recovery systems for a variety of applications and industries.
Chemisch Thermische Prozesstechnik GmbH / CTP Air Pollution Control
based in Graz, AUSTRIA
CTP (Chemisch Thermische Prozesstechnik GmbH) is one of the world`s leading companies in air pollution control for industrial applications. CTP was founded in 1985 and since then, its engineers, chemists and researchers have been developing individual technologies to serve customers worldwide, covering all industrial sectors. At CTP, we adhere to high quality standards ...
Oil Skimmers, Inc.
based in Cleveland, OHIO (USA)
Oil Skimmers, Inc., manufactures and markets Oil Skimming equipment worldwide. Our oil skimmers recover all types of oils floating on water and other liquids and are used in all types of applications from manufacturing, steel mills, food processing, et cetera. We have complete design and application engineering, and our representatives are always available to visit your ...
AWAS GmbH Bayern
based in Oberhaching, GERMANY
The German AWAS is a medium sized companies group with its head quarter in Wilnsdorf and 7 companies in Germany, as well as sister companies in Switzerland, Poland, Rumania, Russia and Ukraine. AWAS has been specialising in manufacturing waste water treatment plants and wash water recycling systems for almost 30 years. Our company's philosophy "for the sake of our nature" ...
TREVI nv
based in Gentbrugge, BELGIUM
Trevi environmental consultancy and technology is a Belgian company founded in 1992 by the present directors. The company is directed by Stefaan Deboosere and Jacky Mortelmans and has a team of about 100 employees with different specialties including environmental consultants, process experts, programmers and installers. This wide expertise offers the client the advantage ...
IMR Environmental Equipment, Inc.
based in St. Petersburg, FLORIDA (USA)
IMR Environmental Equipment, Inc. is one of the leading manufacturers worldwide for portable flue-gas analyzers and stationary flue-gas analyzers using electro-chemical and NDIR technology. Furthermore, the product range includes leak detectors (HC, refrigerant), thermometers, manometers and anemometers. IMR has almost 30 years of experience designing, manufacturing and ...
Ativa Biosciences
based in Mumbai, INDIA
We are a leading manufacturer of advanced biological organic inputs for waste water treatment plants, sewage treatment plants, septic tanks, oil degradation, lake bio-remediation and solid waste composting. Ours is an ISO 9001:2000 certified company. We believe in providing the highest quality products. All our bio products are proven, performance oriented and cost ...
Jiangmen Guangmei Imp. & Exp. Co., Ltd.
based in Jiangmen City, CHINA
Guangmei manufactures solely powdered wood based activated carbon ( phosphoric acid method). Located in a town where there are hundreds of solid wood furniture manufacturers, our factory has rich sources of saw dusts and wood waste. With extra large internal surface area and well-developed mesopores, our activated carbon is ideal solution for industrial water ...
Microbac Ltd
based in Consett, UNITED KINGDOM
Microbac is a privately owned company with 30 years experience in microbial biomass engineering, offering complete wastewater treatment packages to worldwide clients. Our services comprise design, planning, procurement, fabrication, equipment supply, installation, commissioning and testing. A wide range of adapted biological products, including customised bacterial ...
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My Scuba AdventuresRead MoreThe scuba aficionados at My Scuba Adventures immerse their guests in the art of deep-sea exploration, whether by hawking gear at their dive shop or by teaching technique during in-depth certification courses. Lessons cover everything from snorkeling and swimming to wreck diving and underwater navigation. Each course can be completed at the student's pace to fit busy schedules and allow ample time for gills to grow in. Along with a heated pool, the facility serves divers' needs with rental and for-sale gear, repairs, and organized trips to far-off dive locales such as Cozumel and Cuba.4416 Potter RoadMatthews, NC US
Burlington Dive CenterRead MoreBurlington Dive Center is an official PADI school, which means you can expect a few things. The most important of these, of course, is a team of dedicated instructors who teach proper safety techniques and do everything else in their power to prepare students for exploring underwater worlds. But you can also expect to have a lot of fun. It all starts with the center's Discover Scuba Diving program, designed to help total beginners feel comfortable in the water. As you progress, you'll have the chance to take on an open-water course that teaches how to breathe underwater and quickly locate the treasure room in a sunken pirate ship.429 Trollinger St.Burlington, NC US
Sink or Swim ScubaRead MoreBrent Clevenger founded Sink or Swim Scuba in 2006 to provide regular open-water dive experiences to fledging and senior divers alike. He trains neophytes in his full-sized pool, letting them control their buoyancy to drop to the full twelve-foot depth after they master underwater breathing fundamentals in the shallow end. He also oversees scuba certification training during group dives at the Piedmont Dive Rescue Association Lake Norman Quarry. The former dig site provides plenty of underwater excitement with schools of fish and sunken objects to explore, such as the quarry manager's shed which used to house instructions on how not to flood the quarry.4310 Wilkinson BlvdGastonia, NC US


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Abide in style with our exclusive Tapiture Tee Air Dude T-Shirt that features the man we all aspire to be some days—" The Dude. With his famed Caucasian drink in one hand and his beloved bowling ball in another, this robe-clad man will remind you that, "you're the dude, man."
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