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The spectrum of clinical disease caused by the A467T and W748S POLG mutations: A study of 26 cases
ABSTRACT We studied 26 patients belonging to 20 families with a disorder caused by mutations in the POLG gene. The patients were homozygous for 1399 G/A or 2243 G/C (giving the amino acid changes A467T and W748S, respectively) or compound heterozygotes for these two mutations. Irrespective of genotype, the patients exhibited a progressive neurological disorder usually starting in their teens and characterized by epilepsy, headache, ataxia, neuropathy, myoclonus and late onset ophthalmoplegia. However, major differences in survival were seen depending on genotype, with compound heterozygotes having a significantly shorter survival time than patients homozygous either for the A467T or W748S (P = 0.006). Epilepsy occurred in 22 of the 26 patients and in the majority of these there was an occipital EEG focus. Episodes of both generalized and focal motor status epilepticus were common and highly resistant to treatment, even with generalized anaesthesia. Status epilepticus was the recorded cause of death in 9 of 11 patients. Liver failure was the sole cause of death in two patients and evolved terminally in six others, all but one of whom were being treated with sodium valproate. Two patients underwent liver transplantation, but only one survived. Delayed psychomotor development and subsequent cognitive decline also occurs. This study demonstrates the clinical spectrum of a disorder that combines features of Alpers' syndrome and a later onset mitochondrial spinocerebellar ataxia with epilepsy and headache. Patients with this disorder are at high risk of death from status epilepticus and from liver failure, if exposed to sodium valproate. Each mutation appears capable of producing a disorder that is recessively inherited, although we also find evidence in one patient suggesting that heterozygotes may manifest. Compound heterozygotes have a significantly more severe phenotype raising the possibility of a dominant negative effect.
Full-textDOI: · Available from: Charalampos Tzoulis, Sep 29, 2015
- SourceAvailable from: Brendan A I Payne
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- "Three patients had infantile onset encephalopathy with severe epilepsy and strokelike episodes. The clinical and genetic features of all patients are summarized in Table 1 and have been described elsewhere in detail.8,9 "
ABSTRACT: Objective Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration using post-mortem tissue from a large number of patients.Methods Clinical information was available from all subjects. Formalin-fixed and frozen brain tissue from 15 patients and 23 controls were studied employing a combination of histopathology, immunohistochemistry and molecular studies of microdissected neurons.ResultsThe primary consequence of POLG mutation in neurons is mitochondrial DNA depletion. This was already present in infants with little evidence of neuronal loss or mitochondrial dysfunction. With longer disease duration, we found an additional, progressive accumulation of mitochondrial DNA deletions and point mutations accompanied by increasing numbers of complex I deficient neurons. Progressive neurodegeneration primarily affected the cerebellar systems and dopaminergic cells of the substantia nigra. Superimposed on this chronic process were acute, focal cortical lesions that correlated with epileptogenic foci and which showed massive neuronal loss.InterpretationPOLG mutations appear to compromise neuronal respiration via a combination of early and stable depletion and a progressive somatic mutagenesis of the mitochondrial genome. This leads to two distinct, but overlapping biological processes: a chronic neurodegeneration reflected clinically by progressive ataxia and cognitive impairment, and an acute focal neuronal necrosis that appears related to the presence of epileptic seizures. Our findings offer an explanation of the acute-on-chronic clinical course of this common mitochondrial encephalopathy. ANN NEUROL 2014. © 2014 American Neurological AssociationAnnals of Neurology 05/2014; 76(1). DOI:10.1002/ana.24185 · 9.98 Impact Factor
- "Mutations in POLG, the gene encoding the catalytic POLG subunit, are known to cause mitochondrial DNA deletions in neurons (Reeve et al., 2008) and respiratory complex I deficiency (Lax et al., 2012a). Clinically, POLG mutations cause a wide spectrum of disease including myopathy, ataxia, epileptic encephalopathy and liver disease (Van Goethem et al., 2001; Ferrari et al., 2005; Hakonen et al., 2005; Tzoulis et al., 2006). Parkinsonism, including levodoparesponsive Parkinson's disease, has been described (Cottrell et al., 2000; Luoma et al., 2004; Davidzon et al., 2006; Reeve et al., 2012) but is an uncommon manifestation. "
Article: Severe nigrostriatal degeneration without clinical parkinsonism in patients with POLG mutations[Show abstract] [Hide abstract]
ABSTRACT: The role of mitochondria in the pathogenesis of neurodegeneration is an area of intense study. It is known that defects in proteins involved in mitochondrial quality control can cause Parkinson's disease, and there is increasing evidence linking mitochondrial dysfunction, and particularly mitochondrial DNA abnormalities, to neuronal loss in the substantia nigra. Mutations in the catalytic subunit of polymerase gamma are among the most common causes of mitochondrial disease and owing to its role in mitochondrial DNA homeostasis, polymerase gamma defects are often considered a paradigm for mitochondrial diseases generally. Yet, despite this, parkinsonism is uncommon with polymerase gamma defects. In this study, we investigated structural and functional changes in the substantia nigra of 11 patients with polymerase gamma encephalopathy. We characterized the mitochondrial DNA abnormalities and examined the respiratory chain in neurons of the substantia nigra. We also investigated nigrostriatal integrity and function using a combination of post-mortem and in vivo functional studies with dopamine transporter imaging and positron emission tomography. At the cellular level, dopaminergic nigral neurons of patients with polymerase gamma encephalopathy contained a significantly lower copy number of mitochondrial DNA (depletion) and higher levels of deletions than normal control subjects. A selective and progressive complex I deficiency was seen and this was associated with a severe and progressive loss of the dopaminergic neurons of the pars compacta. Dopamine transporter imaging and positron emission tomography showed that the degree of nigral neuronal loss and nigrostriatal depletion were severe and appeared greater even than that seen in idiopathic Parkinson's disease. Despite this, however, none of our patients showed any signs of parkinsonism. The additional presence of both thalamic and cerebellar dysfunction in our patients suggested that these may play a role in counteracting the effects of basal ganglia dysfunction and prevent the development of clinical parkinsonism.Brain 04/2013; 333(8). DOI:10.1093/brain/awt103 · 9.20 Impact Factor
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- "The predominance of liver involvement in the younger child has led to liver transplantation in some patients, but the outcome has been poor and is not recommended for POLG-related disease because of neurological involvement (Tzoulis et al. 2006; Wong et al. 2008). Even though seizures in POLG patients can be resistant to anti-seizure medications, the use of valproic acid should be avoided, because of induction of liver failure (Horvath et al. 2006; Tzoulis et al. 2006; Chinnery and Zeviani 2008). With a paucity of options known to treat POLG-related mitochondrial diseases, it is important to use basic research to understand genetic and environmental changes that can suppress the molecular phenotype related to POLG mutations. "
ABSTRACT: The inability to replicate mitochondrial genomes (mtDNA) by the mitochondrial DNA polymerase (pol γ) leads to a subset of mitochondrial diseases. Many mutations in POLG, the gene that encodes pol γ, have been associated with mitochondrial diseases such as myocerebrohepatopathy spectrum (MCHS) disorders, Alpers-Huttenlocher syndrome, myoclonic epilepsy myopathy sensory ataxia (MEMSA), ataxia neuropathy spectrum (ANS), and progressive external ophthalmoplegia (PEO). This chapter explores five important topics in POLG-related disease: (1) clinical symptoms that identify and distinguish POLG-related diseases, (2) molecular characterization of defects in polymerase activity by POLG disease variants, (3) the importance of holoenzyme formation in disease presentation, (4) the role of pol γ exonuclease activity and mutagenesis in disease and aging, and (5) novel approaches to therapy and avoidance of toxicity based on primary research in pol γ replication.Cold Spring Harbor perspectives in biology 04/2013; 5(4). DOI:10.1101/cshperspect.a011395 · 8.68 Impact Factor


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Extremely caring physician, gives you plenty of time. Dr. Pare is exceptionally thorough and very knowledgeable . She always finds time for you if you really need her.
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Nurses rude and make fun of patients questions
they thought I was a big joke today.
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Dr. Pare anther staff are excellent. They exceeded my expectations from the very first visit. I have been there over 8 years now and although I was a difficult case, my treatment plan is working well. I cannot say enough positive things about Dr. Pare's professionalism, attention to research and detail, and care for her patients' well being.
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I was referred to Dr. Pare by a friend, and had to wait months for the first visit. She, however, the most thorough and patient rheumatologist I have seen. I am completely satisfied with her knowledge, ability to work with me in finding alternative treatment, and concern for my wellbeing. I highly recommend Dr. Pare!!!
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Always makes emergency appointments even if over booked, responds to calls in a reasonable amount of time, pleasant and helpful overall great doctor
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This was my wife's first visit with Dr. Pare for pain in fingertips and toes. We feel that she did a very thorough exam and that she collected alot of information about the issue. She spent about 30 minutes with us, explained what she suspected and described what tests she wanted done to support. She is contacting some of the past Dr's. we have seen to gather the information they have. She did the bloodwork right there in the office. She is contacting our prescription insurance to help get the medicine authorized. The only down side is that it takes a long time to get an appointment with her. This one took 4 months to get. She said she wants to see my wife again in "a few months". The next available date was 4-13-11. In general, we were very happy with the service the Dr. provided. I am hoping the next visit goes as good.
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If you think it takes a long time trying to get an appointment with Dr. Pare just wait until you have a medical emergency and really need her, she won't even show up to the hospital! Dr Pare treated my wife for RA and one day my wife complained of back pain and thought the RA had spread into her back. She called the Dover office and they told her to go see her primary care doctor. The next morning I took her to the ER where she was admitted into the Intensive Care unit. I called Dr Pare until I finally got her on the phone and explained my wife was in the hospital and asked her to come down, She said she would but she never showed up and wife died later that same day. I later found out she was the staff Rheumatologist at the hospital. It turns out the treatment she was on had suppressed her immunity and her body shut down due to septic shock. Good luck under care of Dr Jeanne Pare, maybe she'll have time for you. Our three children still have a lot of questions.
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Dr. Pare is on top of her game: in research, with new treatments, referrals when needed, and in ensuring her patients get the best treatment. A+
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Dr Pare is difficult to get an appointment with initially, which says something about how good she is. Unfortunately even as a patient, my experience has been that she has been difficult to get on the phone (and forget an office visit) for emergencies and when I am feeling really scared. I came to her dx'd but wanted a second opinion. I am still not well controlled (but getting better) and though I agree that my initial consultation was extremely thorough, I sometimes feel like since then she is sort of telling me how I should feel rather than really listening to me. I am an assertive person, but her all business demeanor can be off-putting and I have had trouble feeling like I can openly and candidly express my feelings, thoughts and concerns. So, to summarize, I was initially very pleased with her take charge attitude and optimism, the office staff is OK, but have been a little iffy for follow-ups in the last few months. I am encouraged by the extremely positi
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Nigel Sylvester – Gshock – "Unlikely Encounter" Video
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Mar, 05 2015
Monster just uploaded BennyL's amazing opener section from their Above Below DVD that came out at the end of last year. This is one his best sections to date and it's full of all his signature tech moves along with some burly ones too.
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Mar, 02 2015
The Skavenger X Atown Trash frame is now available! The Atown Trash crew hails from Allentown, Pa have been making DVDs and killing the streets for years now. We're happy we were able to collaborate with them on this frame. Go pick yourself up one.
A Way of Life – Gervais Rousseau
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Longtime friend of Animal, Gervais Rousseau is a legend in the French BMX scene. At 44 years old he is still riding his bike and he recently shared his incredible wealth of knowledge as well as his passion for riding in the form of this short documentary produced by Julien Rodrigues. Enjoy.
The Naviarm – The Streets of Medellin, Colombia
Feb, 06 2015
If you watch only one video today make sure it's this one.
The NaviArm – Medellin, Colombia Promo
Feb, 02 2015
To kick off the new year, Ryan Navazio along with Tom White, Mark Gralla, Garrett Hoogerhyde, Zac Costa, Jackson Ratima and Rob Dolecki all took a trip down to Medellin, Colombia. Above is the promo for the full video which drops this Friday. Make sure you check it out!
Animal Bikes Jam @ 5050Skatepark – Feb 7th
Jan, 30 2015
For the second year in a row, we will be hosting a jam at 5050 Skatepark in Staten Island. Come out on February 7th to escape the cold and ride with some of the dudes from the team. Check out a quick recap of last year's event HERE, don't miss out!
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People Places Bikes X Animal
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1891 $1 PR62 PCGS. CAC....Click the image to load the highest resolution version.
Description1891 $1 PR62 PCGS. CAC. The mirrored reflectivity in the fields is abundantly evident even through the multiple layers of blue, green, and rose toning on each side. The central strike is a bit weak, as usual on this date, and the light hairlines are barely noticeable through the toning.(Registry values: N1793) (NGC ID# 27ZL, PCGS# 7326)
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Internet Software and Services
Company Overview of Shape Security, Inc.
Executive Profile
Derek W. Smith
Co-Founder, Chief Executive Officer and Director, Shape Security, Inc.
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Mr. Derek W. Smith is an Advisor at EPIC Ventures. Mr. Smith is a Co-Founder and serves as the Chief Executive Officer and Director of Shape Security, Inc.
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Microsoft brings its Send hybrid texting-email app to Android
Microsoft is extending availability of its Send hybrid texting-email app for iPhone users and is launching a preview of Send for Android phone users.
Microsoft is extending availability of its Send hybrid texting-email app for iPhone users and is launching a preview of Send for Android phone users.
4K video, Live Photos, bigger apps, and ludicrous price per GB make it a ripoff.
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Oncam has released its new app to the Apple and Google Play stores, aiming to "revolutionize mobile video calls forever".
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The growth in mobile data traffic will continue and should treble to 173PB by 2018 analysts predict.
Can't get your Chromecast to stream video or apps well due to wireless woes? Google has a $15 solution for you.
Microsoft appears to be building an app for fast, light-weight, real-time conversations called Flow, which is likely to debut on iPhone, according to leaked information.
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The next Apple TV reportedly won't support the higher resolution 4k format but it won't matter: Cord-cutting and apps is where it's at.
The Apple Watch launches in a few weeks, but given the new user interaction and controls there are still many questions about how it really works. Apple's new video are very helpful and informative.
Cyanogen Inc nails down its own email app for its commercial OS through a new partnership with Boxer. The new app will arrive in the forthcoming Cyanogen OS 12.
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"Fr. Anthony's Weekly Blog"
Featured News
In Your Kindness
IN YOUR KINDNESS... please pray for all the sick who are being remembered by our Prayer Ministry and, in a special way: Jill Rice, Doris Marohnic, Evie Lausen, Chris Reardon, Dolores Skorpak, Vivian Provo, Justin Smith & Family, Steve Johnsrud, Mark Shields, Dianne Mulcare, , Chris Woody, Mary Franklin, Bill Schwartz, and Ellie Dietrich. Also pray for the repose of the souls of Mary Ann Whisney, Marie Donahue and Mary Reardon who were buried last week.
Communal Anoiting of the sick
Communal Anoiting of the sick will take place on Friday, October 16th at 10:30 AM at the St. Austin Campus. We invite anyone who feels the need for the healing and comfort of this Sacrament to join us on that day. Following the Mass and Anointing, there will be a Senior Lunch in Brennan Hall. While anyone may come to the Anointing Mass, those who want to go to lunch will need to make a reservation by calling the Parish Office during regular office hours. Reservations should be made by Wednesday, October 14th. The usual donation for lunch is $5.00.
Youth Holy Hour & Benediction
Youth Holy Hour & Benediction will be held on Friday, October 16th from 7:00 – 8:00 PM at the St. Bridget Campus. All the members of the parish community are invited to join our young people for a time of quiet prayer, reflection, and music before the Blessed Sacrament.
Centenary Dinner Dance, November 21st
The closing event of our year of Jubilee celebrations will be held on Saturday evening, November 21st. After the 4:30 PM Mass at St. Bridget, we will head over to the Sacred Heart Social Hall in Robbinsdale for a catered dinner and the music of a live band. Dancing is encouraged! Tickets for this event have been reduced to $20.00 per person, thanks to a successful All-School Reunion. It is the hope of the Centenary Committee that you will join us for this event that will close a wonderful year of festivities. It will give us the opportunity to come together as a parish community and celebrate our movement into the future. Tickets are available on-line (below) and in the Parish Office and must be purchased in advance.
Archdiocesan Youth Day 2015
Saturday Oct 24 2015 1:30-9pm Saint Paul RiverCentre Cost: $15 Experience the community of World Youth Day locally with other teens from around the archdiocese for a day of excitement and spiritual growth. Featuring Archbishop Hebda and Bishop Cozzens, Dynamic speakers, Mass, Dinner, Reconciliation, Adoration, and more! Email Alex at email@example.com by Sept 30 to register
Event Tickets
Centenary Year-End Dinner Dance
Date: November 11, 2015
Time: TBA
Place: Sacred Heart Parish Hall


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Product Details
Jeep Wrangler 1999, Sunvisors by Rugged Ridge®. Sold in Pairs. Say goodbye to your old worn out sunvisors and replace them with these tough good-looking ones that are designed exactly like the original part. They are made of durable interior-matching vinyl to complement your vehicle's style.
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Items tagged with hotfix
If you've noticed that Internet Explorer seems to be a little (or a lot) slower as of late, it's not you. Well, it could be; try clearing your cache, make sure no nefarious add-ons slipped through, and scan for viruses. Assuming everything checks out, the issue could related to a pair of security updates that, over time, bog IE down. The good news here is Microsoft made relief just a few clicks away in the form for a hotfix. "After you apply the MS14-037 or MS14-051 cumulative security update for Internet Explorer, web applications that implement consecutive modal dialog boxes may cause Internet... Read more...
Attention AMD fans, if you're running one of those newfangled Bulldozer processors in your system, how would you like a free performance boost? You can have one, so long as you're rocking a copy of Windows 7 or Windows Server 2008 R2. Microsoft this week rolled out a hotfix that's supposed to make things run better automagically. "Currently, the performance of AMD Bulldozer CPUs is slower than expected. This behavior occurs because the threading logic in Windows 7 and in Windows Server 2008 R2 is not optimized to use the Simultaneous Multithreading (SMT) scheduling feature. This feature was introduced... Read more...
If you read our comprehensive review of ATI's new X1K Family of graphics cards, you know how we felt about ATI's new line-up at launch. If you haven't read our review, however, here's the gist of it. We thought ATI's X1K Family of products were a technological step forward, and at the high-end the Radeon X1800 XL and X1800 XT were competitive with NVIDIA's GeForce 7800 GT and 7800 GTX in D3D applications, but in OpenGL based applications NVIDIA's counterparts had an advantage. This particular performance breakdown may be about to change though. ATI has recently posted a "HotFix"... Read more...


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Dang, the BOM005s look so good! Measurements seem just about perfect. These might be my next pair of jeans, I'd love to see a fit pic though.
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Momotaro - Page 180post #2686 of 34604/5/13 at 9:31am
Styleforum Top Pickspost #2687 of 34604/5/13 at 9:34am
- Posts: 253
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Seems like it was only a few pairs from the batch a few months ago at the start of the 702 contest thread. I think you're safe to grab a pair.post #2688 of 34604/5/13 at 10:01am
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Couldn't fit into mine, but they are pretty awesome. If you're slim enough, then get them no hesitation. My pair measured ~ .25" smaller in the thigh and rise than listed on the site. I'm a fat bastard by SF standards so my experience will likely not be yours.
Go for it.post #2689 of 34604/5/13 at 11:15am
Quote:Originally Posted by dusttruffle
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$550 for those?? That's an additional $250 (on top of the $300 list price for 702s) for yellow/gold contrast stitching. Total fanboy purchase IMO.post #2690 of 34604/5/13 at 2:52pm
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You forgot about the Natural Indigo...
Totally plant based and probably dyed by hand. Lot of labour that is reflected in the pricetag.post #2691 of 34604/5/13 at 2:59pm
post #2692 of 34604/5/13 at 5:25pm
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The indigo x natural indigo momotaros are only 400 at blueingreen
http://blueingreensoho.com/site/index.php?page=shop.product_details&flypage=shop.flypage&product_id=13377&category_id=&manufacturer_id=42&option=com_virtuemart&Itemid=62post #2693 of 34604/6/13 at 9:16pmpost #2694 of 34604/6/13 at 10:09pmpost #2695 of 34604/6/13 at 10:10pmpost #2696 of 34604/6/13 at 10:43pm
Quote:I'm loving mine, you won't regret it!Originally Posted by Spencer
- Posts: 213
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- Location: Austin, TX
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Saturday night, at home after dinner slightly buzzed not thinking much about it, pulled the trigger on the Momotaro 1705's from BiG. About to get hot here in LALA land, 10oz denim should come in handy. Hopefully I won't regret since I had them chain stitch them for me....post #2697 of 34604/7/13 at 6:42am
Quote:Originally Posted by i01111000
- Posts: 287
- Joined: 12/2012
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Couldn't fit into mine, but they are pretty awesome. If you're slim enough, then get them no hesitation. My pair measured ~ .25" smaller in the thigh and rise than listed on the site. I'm a fat bastard by SF standards so my experience will likely not be yours.
Go for it.
This was my experience as well, ordered a size 33 BOM005 which has the same measurements from the knee up as my Unbranded 21oz 221's in size 34 (which fit me perfectly). So now I've got to decide if I want to try and stretch them and hope the fit comes around or re-buy a size 34 and try to re-sell the 33's. I got them hemmed so return/exchange isn't an option : /post #2698 of 34604/10/13 at 4:17pmpost #2699 of 34604/10/13 at 4:26pm
Quote:Originally Posted by ginseng
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nevermind, found some. These look pretty damn awesome I gotta say. I love the single lines going down the thigh. Thats one thing that bums me out with raw denim. You can only get one type of "pattern" of the fade depending on how you like your jeans to fit. If you want a fade that looks kinda like the one in the link, you'd have to size looser to get those lines down the thigh (correct me if I'm wrong about that; it just seems to make sense to me).
I'm far from a denim expert, but isn't the "point" of buying raw denim that the wear and fading patterns that ultimately show up are unique to you, and to how and where you wear your jeans? Otherwise, you may as well just buy a pre-distressed pair with the "pattern" you want, no?post #2700 of 34604/10/13 at 4:44pm
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Oooh, it's natural. Cool
Hey guys, come check out this indigo. It's natural, you see! So some old Japanese man dipped these in a vat of blueberries for an hour straight.
So you know it's good.Return HomeBack to Forum: Streetwear and Denim
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Membership of the club is open to men and women of all ages and abilities.
The course is challenging, but enjoyable, and is being constantly improved.
Most of the club's competitions are open to both men and women.
We have reserved tee times on Saturdays and Sundays plus tee times on Wednesdays for the senior section of the club.
The tee times have now been published with the first tee time being at 10am.
Entry sheet for invitation day now available.
The draw for the club match play competitions has now taken place.


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Indian Sadhus keep warm by a fire and do yoga at their camp on the... News PhotoAllahabad,Connection,Fantasy,Fire - Natural Phenomenon,Ganges River,Heat - Temperature,Horizontal,India,Indian Subcontinent,Religion,River,Saraswati Puja,Yamuna River,YogaPhotographer AFPCollection: AFP 2012 AFPIndian Sadhus keep warm by a fire and do yoga at their camp on the bank of "Sangam," the confluence of the three rivers Ganges, Yamuna and mythical Saraswati in Allahabad on December 22, 2012, ahead of the Mahakumbh Mela. The Kumbh Mela, which is scheduled to take place in the northern Indian city in January and February 2013, is the world's largest gathering of people for a religious purpose and millions of people gather for this auspicious occasion. AFP PHOTO/ Sanjay KANOJIA (Photo credit should read Sanjay Kanojia/AFP/Getty Images)


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Receive Breaking News updates as they occur
Bernard Foley's boot and brilliant defence under siege saw Australia beat Wales 15-6 on Saturday to top the World Cup Pool of Death. Australia scored their eleventh straight victory over Wales despite being two men down at one stage and under a relentless red onslaught. Foley kicked five penalties to get all the Australia points in front of 80,863 people at Twickenham.
JERUSALEM (AP) — The latest developments in ongoing violence between Palestinians and Israelis (all times local):
WASHINGTON (AP) — The latest from the National Mall as thousands of African-Americans from across the country mark the 20th anniversary of the Million Man March, calling for changes in policing and in black communities. All times are local.


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The Fan Access platform provides entertainment brands, celebrities, sports teams and musicians the engagement, amplification and measurement tools they need to truly grow and maintain an engaged and loyal fan base.
Brands can easily generate engaging and informative social media conversations and leverage the extensive reach of their fans' social media networks to deliver important content. Powerful reporting and analytics tools effectively measure the success of efforts with key indicators.
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Paradigm is one of the entertainment industry's leading agencies, guiding the careers of an elite roster of clients in motion pictures, television, music, theatre, comedy, publishing, digital technologies film finance and distribution, commercials and voice-overs. Paradigm prides itself on a cohesive team oriented approach to representation, with 150 agents in 8 offices internationally.
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Founded in March 2011, PointBurst is a leading social communication and engagement company focused on providing enterprise solutions across various verticals. The core platform transforms casual fans into brand advocates by making it easy for them receive and share their favorite brand's messages. With PointBurst, brands can easily generate engaging and informative social media conversations that leverage the extended reach of their fans and strengthen their brand.


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Ultimate anti-frizz and top-coat reshapes frizzy and dry mops into sleek, silky, lustrous tresses. Leave-in, weightless, high gloss is perfect for medium to long hair.
The Intensive Oil Treatment is wonderful treatment people who are trying to get their hair back on track after extensive abuse from relaxers. The blend of macadamia and jojoba oils conditions the scalp and softens the hair, lubricating it, replenshing the natural oils, helping the hair look shiny and healthy. Vitamin E adds deep nourishment to the hair shaft and roots while Clary Sage oil adds...
This all natural styling jelly provides a gentle, flexible hold and ringlet curl definition to all curly hair types! Great for Wash-N-Go styling and quick curls.
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Whipped cream wax that offers flexible hold with a lightweight finish for curly or wavy hair. Creates a soft but controlled touch while adding movement and shine.
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39 years of experience
Accepting new patients
317 W Pueblo St
Santa Barbara, CA 93105 Phone number & directions
Patient Reviews
Patient Reviews ? Write a Review
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I called today (friday) to get an appointment to receive treatment for a sinus infection that has been ailing me for the past three days. I spoke to a wonderful woman who relayed my message to Dr. Messerlian's office, she said they would call me back. I received a voice mail minutes later from the nurse, she conveniently left out her name and informed me that if I had called earlier I would have been able to get an apt. She said "we close at noon today, which is in like an hour, so you will need to go to the urgent care if you want" her tone was very agitated and unpleasant. Discouraged I called back and spoke to another women who spoke to me about all the possibilities why the first woman was so short and un-personable with me, after sitting on the phone for 10 min. I ended the call with no apt. Really miss my private doctors office experiences, with staff who care about their patients.
Excellent physician in every way !!!


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Where did you go on holiday this year? Did you visit a theme park?
We want to know all about your holidays this month and for every review you add you'll be entered into our prize draw to win £250 to spend on Virgin Experience Days (great for Christmas presents!).
Find out more about the competition here
THE ILLUSIONISTS - WITNESS THE IMPOSSIBLE™ - the world's best-selling touring magic show which has sold out in 71 cities across 17 countries - comes to London's West End for the first time. Guest starring the UK's hottest magician Jamie Raven, fresh from Britain's Got Talent, where he captivated the British public with his unique magic tricks.
For more information and to enter pop over to your local competition page here: http://www.netmums.com/loca-to-you/local-competitions
We have another great competition to win Family tickets to see Zippos Circus! Plus a chance for a fantastic photo opportunity!
For details on how to win these some tickets, please look at our Local competitions page.
Everyone is in with a chance to win!!
The first prize of a photo opportunity inside the Globe of Terror AND a Family Ticket goes to.....(drum roll)
The four runner up prizes of a Family Ticket each goes to....
Pui, Elaine, Lloydd and Steve
Have a great time!
Circle of Security Parenting Groups run for 8 weeks (each session: 1.5 hours). The Circle of Security is a brilliant take on parenting young kids, and is used all over the world. This term we are running two groups on a Thursday and Friday morning (starting 24th and 25th Sept). The groups are a great way to meet new parents and to take time out to think about what our children need from us to thrive. We all know that being a parent can be deeply wonderful and horribly frustrating. We all feel stuck sometimes. We want to be the best parents we can be but we just can't work out what to do when they act like that! Circle of Security Parenting groups are for you if you have ever felt you have more questions than answers.
In the groups we take time to think about our children's physical and emotional needs in order to understand why our children behave in certain ways.
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For all the mums-to-be and new mums in Pimlico and Westminster!!! Mummy Conditioning is a new group exercise programme especially designed for you! Classes are starting at The Dolphin Fitness Club (Dolphin Square, Chichester St, London SW1V 3LX) on 12th October at 6pm. For more info, prices and bookings drop me an email: email@example.com. Looking forward to seeing you all!!
Comfort Pure are looking to find new-born babies to appear in a beautiful new TV advert capturing the breath-taking, precious moments of an infant's early days in the world.
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Tradition Window Cleaning has been providing professional domestic window cleaning services and office window cleaning in Westminster since 1982
Our head office and vehicle depot is based on Victoria Street, SW1 giving us a perfect location to cover all of Westminster with most locations reachable in minutes.
During our 32 years of business we have become one of Londons most trusted commercial window cleaning company providing our services to clients ranging from individual flats & houses, offices and small private companys to entire Government offices of state!
Whatever your requirement - we can deliver the window cleaning service that is best for you!
We would love to hear about any events coming up for October Half Term, Halloween, Bonfire Events and ahem yes Christmas too (only 99 days away!!). Its such a great time of year for lots of family fun activities.
Please do add the events to our What's On page, thanks :)
Hiya, I run a local school run service and we are planning on having an event for Halloween, We will collect children and parents( if they wish ) for a fun filled evening of trick or treating.
We will provide travel, snacks and face painting onboard or minibus.
If you need anymore information please let me know.
This sounds great and ideal for our What's On page, drop me an email on email@example.com with more details thanks :)
If so, we hope they're settling in nicely and that you and they aren't missing their old nursery/pre-school/childcare too much!
We'd love to hear what you think/thought of their old nursery/pre-school/childcare on our Childcare pages - do pop over, and add a review there :0)
Podengo are seeking the views of family men and women aged 35 – 60 years about financial products. (Children may be at home or grown up and left)
You will receive £45 as a thank you for taking part.
For more info and to apply: http://gopodengo.com/projects/project.php?event=2015-09-30-family-men-and-women-aged-35-60-years-needed-for-financial-product-research-ref-saturday-iii
Thank you :)
The Tavistock Centre for Couple Relationships' Parents as Partners is a safe space for couples and co-parents to work out how to move forward if things have been difficult. It is a free programme that looks at the whole family, not just the relationship between parents and their children. The free 16 Sessions (one per week) are led by trained group workers who work with both parents to foster long lasting change. Both parents are involved in sessions, and the group is always led by a male and female pair of trained workers.
You and your child's other parent will attend sessions with other parents.
Parents as Partners has proven results in helping:
- Improve your relationship and communication with your child's other parent
- Strengthen your family relationships and improve your child's wellbeing and success
- Manage the challenges and stress of family life
- Reduce conflict in your relationship.
The programme is for parents with at least one child under 11 years old. Free childcare is available at the sessions. Parents must be over 18 years of age. To take part in the programme you don't have to be living with your partner, or be in a current relationship, but you do need to be willing to talk together about how you would like to bring up your children.
The next groups run by TCCR will be at venues in:
• Westminster, Hammersmith & Fulham and Croydon.
Visit http://www.tccr.org.uk/relationship-counselling-service/parents-as-partners-programme for more info.
Have you ever had difficulties trying to get an appointment with your GP?
Would you be up for grabbing a coffee with a former plastic surgeon to talk about an exciting new app that will allow you to 'Uber a doctor' to wherever you want?
GPDQ is launching soon in central London and will be the UK's first doctor-on-demand app.
We are interested in chatting with people who find getting a GP appointment a real pain and want to use technology to help.
Happy to meet wherever you want in central London for a coffee and would only take 30 mins.
If interested please email: firstname.lastname@example.com
Dr Will Doward
I've got a great chilli sauce business chillidrops.co.uk. Looking to give an adventurous mum some invaluable work experience, in a relaxed and welcoming environment. I'll teach you everything about the business and we can work on your CV if you want to move in a different direction. Very flexible hours and lots of fun guaranteed. No experience necessary, but as your a mum I'm sure your the most organised person ever ;)This is an unpaid role and the office is in Marble Arch.
07527 086 981
From our friends over at Bluestone Wales National Park Resort
New for 2015 – Christmasland at Bluestone National Park Resort.
Join us between the 6th of November and the 3rd of January 2016 and receive FREE tickets to Kingdom of the Elves when you make a booking! Breaks from just £179!
Please come along with friends and take a look around our great nursery.Meet our highly skilled team and join in with our fun activities. If you join us by November 2nd we will deduct 50% off your first invoice. Come and meet staff ,children and parents.Don't miss this great opportunity phone us or just turn up.
View our Noticeboard guide for more information.
Talk to an expert 7 days a week 8am - 9pm 0800 380 0061 or 0203 092 5258 from a mobile


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Peace, Safety, Loving Care
Angels Way provides a loving and nurturing Christian home where pregnant women have a supportive place to live, while also receiving education, guidance and career counseling.
Angels Way in Canoga Park is a program home for single, pregnant women eighteen years of age or older who have chosen to give their babies the ultimate gift . . . life. The residents, with the guidance of a program administrator, are given direction and positive role identification in a nurturing and supportive environment.
Angels Way's objective is to assist each woman in developing a sense of self-worth and to help her become a responsible, productive, self-sufficient individual. Read Full Program Details
Thanks to the generous matching gift of Richard and Lissa Sholty, all donations (up to $10,000) between now and November 30, 2015 will be DOUBLED!! Please be as generous as you can to help us reach the $10,000 goal. Thank you in advance and God bless you.
Give to Angels Way:


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SB&D Travels
SouthernAutoCorridor.com News
Southbound: From the Editor
Around the South
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2015 SB&D 100 Edition
Ten smoking-hot small market economies in the South
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Ten powerful major market economies in the South that don't get enough national attention
Ten outstanding markets driving large MSA economies
Ten Comeback Kids
Ten more places in the South to hire vets
Ten great Southern downtowns – big and small – that are worth a visit
Ten rail, air or interstate frontage sites in the South perfect for any large manufacturer
Ten economic development programs in the South worth a look
Ten people who made a difference
Fall 2014 Edition
Selling Your Rural Community's Assets
Kentucky Supplement
Kentucky: The Spirit of the South
New Build-Ready Program Making More Sites Ready-To-Go
A Perfect Partnership
Next Gen KIH Program Taking Broadband to Every Corner of the State
2015 Aerospace Bonus Edition
Aerospace Industry Takes Off in the American South
Launching Pad for Growth and Innovation
In "Plane" View
"The Best Airplane Built in America"
Petrochemicals and the Southern Manufacturing Renaissance
Non-Petrochemicals and the Southern Manufacturing Renaissance
Ten Reasons Why Manufacturing is Booming in The South
Rural unemployment rate in Virginia dropped a point in 2011
By Lee Burlett
The rural regions of Virginia are some of the most stable in all of the rural American South. But don't tell that to leaders in Virginia. Historically, economic development officials and politicos in The Commonwealth have displayed a consistent air of insecurity about their rural regions over the years. It is something that we have never understood considering rural regions in Virginia typically outperform rural regions in all but one or two Southern states in overall employment rates.
On the surface the fact that rural Virginia has consistently outperformed states such as Alabama, South Carolina and Tennessee defies logic. The aforementioned states all have burgeoning automotive clusters. The automotive industry is the 800 pound gorilla in the room so to speak when it comes to rural development. No industry employs more people in Small Town South than the automotive industry.
Virginia, on the other hand, has a small automotive cluster, but nothing like that found in Alabama, Kentucky, South Carolina or Tennessee. Like all states in the Southern Automotive Corridor (www.SouthernAutoCorridor.com), Virginia would do everything possible to land the biggest prize in economic development in the South; a major automotive assembly plant.
Virginia has also historically been the home to industries that have been hammered, such as the furniture, textiles, tobacco and other manufacturing and agribusiness sectors that have left in droves over the last 15 years. So, what's up with the rural economy in Virginia where in 2011 it shed a point off of its unemployment rate from 7.84 percent in November 2010 to 6.85 percent in November 2011? That's right, rural unemployment in Virginia's counties was below 7 percent in November, compared to 10.2 percent in Alabama, 11.4 percent in Tennessee and 13.7 percent in South Carolina, three of the four-largest automotive states in the Southern Automotive Corridor.
Rob McClintock, Director of Research for the Virginia Economic Development Partnership, has an idea why Virginia's rural areas regularly outdo other Southern rural economies. "Virginia has a number of small, medium and large-sized MSA's sprinkled all over the state which have close proximity to areas that are truly rural such as the Middle Peninsula, Northern Neck, the Piedmont and Southside. This allows employees to be mobile and travel relatively easily to places of employment. Virginia's highway system helps reinforce this case of transit in the rural/edge communities. This helps keep the employment rates higher than places that are more remote. More distributed metros lead to statewide economic diversification and relative prosperity," McClintock said.
McClintock went on to say that the rural areas of Virginia have been helped in recent years by massive state and federal investments in broadband capability. "This has spawned a number of non-traditional, service and information technology-sector jobs" in rural regions of Virginia.
Linwood Wright, a former mayor of Danville, Va., which is located in the Southside region, weighed in on the issue. "I would make the argument that Virginia has a lower rural unemployment rate than other Southern states because it has historically dealt with economic development in rural areas for three decades with the realization that these traditionally high manufacturing areas were going to be hammered by the movement of textiles, tobacco and furniture to off-shore manufacturers. The Commonwealth did not wait for the demise of these industries to create a crisis, although the sudden loss of large segments of employment in southern Virginia certainly created major problems. There are still pockets of high unemployment in sections of rural Virginia and the economic development activity is feverish in those areas," Wright said.
He also supported McClintock's assertion: "Virginia benefits from major federal government employment, which in many areas of the state spills over to more rural jurisdictions as people commute further to work. Realistically, rural Virginia is more difficult to define than in other states in the South because of these commuting patterns," Linwood said.
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20th Anniversary Edition
Steering the Automotive Industry to the World's Fourth-Largest Economy
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Open Channel Solutions ReviewsOpen Channel Solutions 5
Great place to learn about public relations, marketing, innovative solutions and administrative work. Great team members who are willing to help throughout internship.
Sometimes difficulty asking questions to upper management and sometimes direction cofusing. Overall, great work environment
Open Channel Solutions Awards & Accolades
Let us know if we're missing any workplace or industry recognition – Add an award
Additional InfoUnlock Profile
Open Channel Solutions (OCS) hopes to help your software licensing efforts sing in perfect harmony with your customers. The company offers its POETIC software products and services to help software publishers manage their software licensing agreements. OCS began as the License Administration Services division of R. R. Donnelley in 1990. The division was then spun off as a part of Modus Media International, and then became an independent company in 2000. In 2008 the company was acquired by ModusLink Global Solutions (formerly CMGI).


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It was about five years ago that Mayor Tim Kent first mentioned to us that he wanted to raise or replace the old railroad bridge over Main Street in downtown New Albany. The mayor thought the bridge, with the misspelled word painted on its side, was not attractive and was a safety hazard for trucks […]
Not "pie in the sky"
County takes next step in $3 million industrial project
The Union County Board of Supervisors was able to move ahead with efforts to obtain a capital improvement loan of up to $1.5 million Monday, after no one objected to the plan at a public hearing. The money, along with a $1.5-million Community Development Block Grant being sought, will be used for what officials are […]
Traffic stop leads to encounter with West Coast 'hippie' group
The Union County Sheriff's Department experienced a flashback to the Age of Aquarius this past week when it encountered a group of what might be described as counter-culture musicians passing through the area. Sheriff Jimmy Edwards said canine officer Adam Fitts was on patrol about 1:30 a.m. Thursday on Hwy. 78 when he got behind […]
Senior Citizens Day set for May 21
The annual Senior Citizens Day presented through a grant with the Union County Sheriff's Department will be next Thursday, May 21, at the Union County Fairgrounds. The program will again be in the arena and begin about 10:34 a.m. As usual, a fish lunch will be served at noon. Sheriff Jimmy Edwards said Doug Hill […]
Local law enforcement participating in 'Click It or Ticket' safety campaign
The New Albany Police Department is again participating in the national Click It or Ticket safety program that runs May 18-31 and includes the Memorial Day Weekend. The department has received a grant that will pay for overtime to allow officers to set up checkpoints and add patrols to check for seatbelt and child seat […]
City school board honors clerk
New Albany Superintendent of Schools Jackie Ford, right, presents a certificate of appreciation to Melanie Anderson. The board of trustees wanted to thank Anderson for her outstanding work as clerk of the board and had the certificate created. She also is the executive assistant to Ford, as well as keeping other school district operations running […]
City arrests four for variety of drug-related charges
What at first looked like a nuisance call turned into four felony drug arrests and the seizure of a variety of illegal drugs and paraphernalia for New Albany police this past Friday. Chief Chris Robertson said the case began about 9 a.m. on Hwy. 348 when someone reported hearing popping sounds. An officer got behind […]
Community observes National Day of Prayer
About 100 people came to the courthouse lawn Thursday to observe the National Day of Prayer. The theme this year was "Lord, hear our cry." Those attending were welcomed and viewed the presentation of colors by the New Albany High School Junior Air Force R.O.T.C. and the playing of the national anthem. Area pastors then […]
Nationwide Groupon campaign raises over $335,000 for law enforcement K9 protective vests
The Union County Sheriffs Department's K9, Dutch, has received a ballistic vest thanks to a nationwide Groupon event that has raised over $335,000. The "Occasions" campaign for Groupon Grassroots to outfit police K9's with bullet and stab protective vests ran February 15 through March 5. Vested Interest in K9s, Inc. was the nationwide non-profit organization […]
Alcohol in the park
The New Albany Board of Aldermen voted Tuesday to allow its tourism department to serve alcohol at a dinner May 22 in the Park Along the River. The board voted 3 to 1 to allow alcohol to be served at a $50-a-plate event in the public park. Voting in favor were Aldermen Jeff Olson, Scott […]
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Arizona Cardinals
Cardinals defense is rough on opposing QBs
If you're wondering why Ray Horton is considered a hot coaching commodity while he's working for a team that is a disappointing 5-9 through 14 games, the answer is simple.
His defense is hell on opposing quarterbacks.
ESPN.com's Mike Sando and ESPN Stats & Information crunched the numbers and the results are startling.
Of the 12 starting quarterbacks the Cardinals have faced this season, nine of the them have performed substantially lower than their season standard based on ESPN's Total QBR statistic. Only Green Bay's Aaron Rodgers, San Francisco's Alex Smith and Miami's Ryan Tannehill have performed better against Arizona than their respective season marks.
The 12 primary quarterbacks Arizona has faced to this point in the season have combined to complete 54.5 percent of their passes with 16 touchdowns, 21 interceptions and a 33.3 Total QBR score against the Cardinals.
Those same quarterbacks have completed 62.8 percent of their passes with 212 touchdowns, 112 picks and a 61.2 QBR score against everyone else.
It'll be interesting to keep an eye on what Chicago quarterback Jay Cutler can do against a recharged Cardinals defense Sunday.
In case you're wondering, Cutler's Total QBR for the year is 49.5 with 17 touchdowns and 14 interceptions.
Most Popluar
Cardinals Audio
Damien Anderson - Former Cardinal and Member of the Arizona broadcast team
Friday October 9
Damien Anderson breaks down the Cardinals vs Lions game.
Josh Weinfuss and Michael Rothstein - NFL Nation Reporters
Friday October 9
Do the Cardinals or the Lions need the win more?
John Clayton, ESPN NFL insider
Friday October 9
John Clayton says the Cardinals are the best team in the NFC West, but they aren't the most talented
Ron Jaworski, ESPN NFL analyst
Thursday October 8
Ron Jaworski discusses whether the Cardinals have some issues or if the Rams game was just a fluke.
Mike Stone, 97.1 The Ticket Detroit talk show host
Thursday October 8
Mike Stone discusses the Lions loss to the Seahawks and whether Detroit is cursed.


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Extended Stay America - Atlanta - Duluth
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On My Way!
While listening to my most favorite song at the moment (Turtle, by Alana Davis), I've realized my trip has BEGUN!!!! It wasn't real until now. I'm sitting at my seat on my way to JFK airport, waiting for my dinner, and I don't really have much to say except that my excitement is finally here. No worrying, no doubting, just excitement. That's all for now. Sorry if you found this post boring, but sometimes you just gotta gloat. Love you ...
... I last sore Linda well over 30 years or more. We had a great evening, great food and it was a shame we could not of stayed longer but we had already made plans to in North Carolina.
Atlanta-Tour End-Honolulu
... at the The Circle across the road from us and Bruce and Elizabeth were enjoying a cruise around Florida. We will email no doubt. We were on the other side of the airport than the other guys. At this time of morning we walked straight up to the counter to check in. The guy was able to sort our seating out and across the aisle from Atlanta to Dallas and together Dallas to Honolulu. From there we went through security and because of our Qantas Club we were in the priority line. I ...
Thanksgiving in ATL
... free rum and sprite en route to Atlanta.
Not even ninety minutes later, we land in Atlanta, and instantly I notice a difference with ATL. There are plenty of flights moving around, but the airport feels like it's at a fraction of the capacity that I've seen it on other layovers. I would say it was probably around 40-50% of what I normally see and that was probably a far cry from what the crowds were like there just the day before on Wednesday ...
Work & then shopping
... doesn't help that public transport is so poor. Pretty productive at work today, got a lot signed off, and clients are enjoying the accent. Everyone also always seem to mention their own British heritage, and ask whether I like the Royal Family. Went to a mall after work - picked up some stuff for ...


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They're all beautiful ! You've got the eye of an artist.
Hi Al,
great !
Espectacular puesta de sol. La luz, las nubes, el color son magníficos. Una gran foto. Enhorabuena.
Very beautiful picture
Fantastic colors and composition
Best regards from Basque Country (Spain)Marije
YSL for photo and your gallery. Have anise weekend. Hanka
Photo taken in Uvatsky District, Tyumen Oblast, Russia


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I have an abundance of photos for July, so I have grouped some together otherwise this post would go on forever and ever.
Above are a selection of flowers, the most beautiful smelling roses, an exotic sunflower, hydrangea from below and a whiskery caterpillar on a wild flower. There were literally hundreds of these caterpillars in a very small area
Photos from the seashore.
This year the sea hasn't tempted us to go swimming in it, it has been so choppy at times, brrrrrr. I do love just walking along the beach as each tide reveals a new set of treasures. The jelly fish intrigues me, the seaweed is always fascinating, the weather and tide worn rocks creating interesting patterns and of course, just watching the tide roll in & out.
The colours at Portmeirion get me every time. I just love them and all the quirkiness that comes with this fascinating place. And it now has the best ice cream for miles and miles. Our old favourite Cadwaladers has been taken over, not only has the ice cream become mundane, the portion sizes are ridiculously small for the price. We went there once this time, and have not returned!
I seemed to take a lot of red photos this year! It's not a colour I go mad for usually. (It was my most favourites colour as a child) but not anymore. The bottle brush plant was one of the many beautiful plants at Portmeirion, the tomatoes for sale in Portmadoc and a bottle of bubbly water from home.
Wild rabbits have hopped along to see us almost every day, we even saw a hare! Aren't they so cute.
I always try and take my current favourite clothes with me. Love this dress from Gudrun Sjödén, I knew it would match Portmeirion, to be honest, I really haven't brought enough warm clothes. I have ended up pinching a hoody from my lovely son! They are such a useful item of clothing, I can see why youngsters wear them all the time!
There have been a lot of mermaids purses on the shoreline this summer, I have been collecting them, I find them so beautiful, they look black, until you hold them up to the sun or a light and they transform into a gorgeous amber/golden syrup type colour. I wonder what they are made from! I love the twirls and spirals that come off the ends
My amazing camera has been put to good use again, we really do stay in a very beautiful part of the UK, lots of lush countryside with beaches nearby
I brought my paints with me this time, I am so missing my needle and thread, I love painting, but it is so hard to be creative!
We have had to light the fire more than usual, it has been cold and damp, it does make it cosy though, and a bit smoky at times!
And again, another tiny planet, perfect for Portmeirion, I have photographed this amazing place so many times, it's nice to be able to take it from a different angle!
Before I left, I was working hard on my textiles, I have an exhibition coming up in September, but not only that, I really enjoy creating, every time I produce one thing, more and more ideas pop into my head! This one has feet on it which are hidden by the long grass, I think the lavender is perfect for it!
The sheep were having a lovely time on the cliffs, quite wary of us! This is one of our favourite walks and has spectacular views from high up.
Another shot from our garden before we left, please, bring back the summer! It has rained heavily all day today....
And finally, thank goodness, I hear you say, a panoramic of our usual picnic spot at Portmeirion.
As some of you know, I now use Instagram much more frequently than writing a blog, it is so much quicker, and a wonderful visual diary. I now have more followers on Instagram than here. Here, on blogger I am losing them! And there is much more communication on Instagram! However, I am not giving up on my blog. It is fascinating to re-read, (for me) and reminds me of so much over the years. After all, it's for me and my family.
See you soon Sx


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Two Portage residents were arrested Friday after $3,000 in U.S. currency, narcotics, a "large quantity" of marijuana, documentation and drug paraphernalia were seized from 139 E. Howard St. in Portage.
Jimmy "nmi" Chandler, 38, and Molly A. Patchin, 35, were arrested after law enforcement officials executed a search warrant at the address on Friday, according to a news release from Columbia County Sheriff Dennis Richards.
The release said Patchin was arrested at the address and Chandler was arrested elsewhere in the city.
The release said the arrests followed a joint investigation by the Portage Police Department and the sheriff's office.
The release said both were charged with felony possession with intent to deliver marijuana of more than 200 but less than 1,000 grams, felony maintaining a drug trafficking place, misdemeanor possession of a scheduled controlled substance, and misdemeanor possession of drug paraphernalia.
Chandler also was arrested for violation of probation.
The release said additional charges and arrests were anticipated in the investigation.


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Includes digital copy + 1 print. Each additional print is $3.95
L'Ultima Notte
By Josh Groban - Digital Sheet Music
Product InformationL'Ultima Notte by Josh Groban - Digital Sheet Music
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Publishing administered by: Kobalt Music Publishing America, Inc.


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As much as we'd like to talk about Sony's increasing hospitality toward independent developers, we're a little too anxious. You see, the company has just added an indie games channel to its handheld console, with Hotline Miami as the flagship title. Users will also be able to grab 53 other titles, like Thomas Was Alone, Sound Shapes and Limbo, but we're too busy with Hotline Miami to pay attention right now. Sony is also promising that we'll see Spelunky, Terraria and Hohokum in the next few months, which'll keep you entertained when you've finished, you know, Hotline Miami. If you'd like to catch a trailer showcasing all the new games, head on past the break.
- Key specs
- Reviews • 3
- Prices
- Discussions
- Game format Downloadable, Cartridge
- Touchscreen Capacitive [finger]
- Direction control D-pad, Thumb stick
- Motion controls Accelerometer
- Released 2014-05-06


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Sheriffs and chiefs of police from three parishes will gather to announce their support for continuing the tolls on the Crescent City Connection.
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Vendor: Zondervan
Publication Date: 2009
Availability: In Stock
Dobsons transition from someone who follows Jesus to someone who lives like Jesus takes him into bars, inspires him to pick up hitchhikers, and deepens his understanding of suffering. As Dobson discovers, living like Jesus is quite different from what we imagine.
In The Year of Living Like Jesus, Dobson chronicles his humbling and inspiring year in Jesuss sandals. Like A. J. Jacobss bestseller, The Year of Living Biblically, Dobsons book is funny, challenging, and provocative. With great candor and wisdom, he invites readers to join him on a year of revelation a year that changed his spiritual life forever.


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Interactive Seating Charts
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Workplay Theatre500 23rd St S
Birmingham, AL 35233
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Share your experience
Other names: Provera, Medroxyprogesterone
Method of use: Injection
Prescribing mode: Rx
depot medroxyprogesterone acetate (DMPA) long acting reversible contraceptive hormonal contraception birth control drug that is ...Read on Wikipedia
2.55 0.5 35294
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Depo Provera for Pregnancy Prevention
We analyzed what people said about Depo Provera and compared it to other Pregnancy Prevention medications
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Does Depo Provera cause Bipolar Disorder?
#40 in Depo Provera discussions - 96 posts discuss Bipolar Disorder with Depo Provera. Bipolar Disorder is #40 concern in Depo Provera discussions.
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he Depo Provera shot and she has bi-polar but is not o...
" Depo Provera And Bi-polar? my girlfriend is looking in to getting the Depo Provera shot and she has bi-polar but is not on... "
prevent me from having a period. This proved a mistake -...
" ...it gets better soon! My bipolar symptoms are absolutely worse when ...are much more acute. Before I was diagnosed with bipolar disorder, an Ob-Gyn prescribed depo provera shots to prevent me from... "
poprovera, It was literly making me bi-polar. The doctor di...
" ...except ADHD. When I was on Depoprovera, It was literly making me bi-polar. The doctor didn't even hesitate to give me xanax. Its a low dose, ...of which I was on Depoprovera. I don't usualy take the... "
ime when I was on the shot and I became pretty much bipolar;...
" re: Depo provera and miscarriage.. is there a connection I was on the shot for a little over two years. I started feeling sick all the time when I was on the shot and I became pretty much bipolar; so... "
ed bipolar because I was on depo-provera, and have stopp...
" ...have only been on seroquil (an antipsychotic that in large doses helps with the manic part of bipolar) and concerta (for ADHD) in these past two years and have been doing fine. My doctor and i... "
since I had my abortion in 2005. I had the worst cramps...
" I have been on Depo-Provera since I had my abortion in 2005. I had the worst cramps, bleeding for 3 months, diagnosed with Bipolar and depression, I have severe migranes everyday... NO MATTER what... "
else had been on Depo Provera shots or had the implants and...
" ...have emotional/mood disorders. I have Bipolar disorder and i am a little ...and was wondering if any one else had been on Depo Provera shots or had the implants... "
e about depo provera which caused me really bad depression b...
" Birth control for bipolar ? bipolar and wanting to get on ...my doc warned me about depo provera which caused me really bad depression ...my mood or anxiety, i went on nuvaring b4 and that seemed well, but... "
actually went on Depo Provera (that 3 monthly contraceptive...
" *big hugs* I too have bipolar and understand the meltdown around lady time. I actually went on Depo Provera (that 3 monthly contraceptive shot)... "
ave experience with Depo provera ? Surprising enough i sea...
" Depo provera Anyone with Bipolar notice drastic change with moods and such or have experience with Depo provera ?... "
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BIG BOY likes to extend his (slightly odd) views on Faith, Love, Hope; on dreams and his grand future.
What he does not like is talking about his puzzling past, which has never been discussed in the open public before.
His music is the rare, once-in-a-lifetime chance to sneak a little peak into the methods of this living phenomenon's madness...
"Being the biggest German speaking entertainer since Marlene Dietrich and the greatest fake since Milli Vanilli is a bit overwhelming at times. I just want to be loved!" - BIG BOY


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Archive for the 'Press Releases' Category
April 18th, 2013 at 9:32 am
ABC News' 'Good Morning America' is Number 1 for Week of April 8th
ABC News' "Good Morning America" stood as the morning's No. 1 newscast in both Total Viewers (5.494 million) and Adults 25-54 (2.045[Read-More]
April 18th, 2013 at 9:28 am
Jewel to Perform 'Stageside Live' Webcast Concert on Wednesday, May 1
April 18, 2013 - AT&T*, CBS Interactive and Stageside Productions' live webcast concert series, STAGESIDE LIVE, will feature four-time GRAMMY® Award nominee[Read-More]
April 18th, 2013 at 9:19 am
ABC & ESPN Release NBA Playoffs TV Schedule
The NBA Playoffs will exclusively tip off Saturday, April 20, on ABC and ESPN with four Game 1 presentations. The[Read-More]
April 18th, 2013 at 9:16 am
CBS Sports Broadcasts 45th Year of PGA Tour's 'RBC Heritage'
CBS Sports broadcasts the 45th year of the RBC HERITAGE this weekend from one of the most picturesque and popular stops on[Read-More]
April 18th, 2013 at 9:12 am
'Face the Nation' is the Number 1 Sunday Morning Public Affairs Show
CBS News' FACE THE NATION WITH BOB SCHIEFFER is the #1 Sunday morning public affairs show. FACE THE NATION finished first in[Read-More]
April 18th, 2013 at 8:13 am
TNT Releases 2013 NBA Playoffs TV Schedule
TNT, in its 29th consecutive year of NBA coverage, will televise more than 40 playoff games – the most of any network[Read-More]
April 18th, 2013 at 8:08 am
'The Weight of the Nation for Kids': Two Specials Debut May 7 on HBO
In May 2012, the groundbreaking multi-part documentary series "The Weight of the Nation" explored the facts and myths of the obesity epidemic[Read-More]
April 18th, 2013 at 7:44 am
TR3s Launches Contest to Give Juanes Fans the Interview of a Lifetime from the 'Loud and Unplugged Tour'
Tr3s and SUBWAY® restaurants join forces to launch their annual music-driven contest offering viewers nationwide the exclusive chance to win a coveted[Read-More]


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Carmel Valley
12750 Carmel Country Rd
San Diego, CA 92130 Phone number & directions
12750 Carmel Country Rd
San Diego, CA 92130 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Raul Garca:
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- Additional Information
- Dr. Raul Andres Garca DDS is a male dentist and practices in Family Dentistry.
- Where does Dr. Raul A. Garca practice?
- Dr. Raul Garca has 2 office locations.
Dr. Raul Garca practices Family Dentistry near San Diego, CA.
Additional practice locations include: Encino, CA.
See San Diego Dentists.


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Miners' Mason pockets Esky medalist honor
May 8, 2015 ESCANABA — Gladstone took the team title, but it was fourth-place Negaunee which got boys medalist honors in a high school golf meet when sophomore Carter Mason defeated Braves' junior Max Strasser... more »»
Ishpeming, Negaunee continue jockeying for victories
May 8, 2015 NEGAUNEE — Ishpeming and Negaunee switched positions Thursday at a high school track meet held in Negaunee. more »»
Ishpeming, Negaunee roar; Redmen shut out
May 8, 2015 ISHPEMING — Strong from start to finish, the Ishpeming High School boys tennis team swept visiting Norway Thursday, 8-0. more »»
Mustangs just miss track double dip
May 8, 2015 RAPID RIVER — The Rapid River girls appear to be hitting their stride as they placed third in their own invitational track meet Thursday. more »»
Miners take a pounding
May 8, 2015 NEGAUNEE — It just wasn't the Negaunee High School girls softball team's day on Thursday. The Miners were thumped twice by visiting Gladstone, 13-0 and 15-0, to fall to 8-12 on the seaso. more »»
A day of firsts
May 7, 2015 MARQUETTE — Brandon Lotterman picked a good time to post his first career walk-off hit. more »»
Westwood's Beauchamp named U.P. Sports Hall of Fame scholar
May 7, 2015 ISHPEMING — Courtney Beauchamp of Westwood High School is one of four Upper Peninsula high school student-athletes selected to receive a U.P. Sports Hall of Fame college scholarship for 2015. more »»
Negaunee, Westwood post wins, Munising earns tie
May 7, 2015 MARQUETTE — The Negaunee Miners boys tennis team continued its strong play Wednesday with a 6-2 victory at Marquette. In singles, Negaunee No. 1 Parker Bowman and No. more »»
Redettes win in shootout
May 7, 2015 KINGSFORD — Marquette and Kingsford waged another defensive struggle on the soccer pitch Wednesday at Commemorative Field. more »»
Shorthanded MSHS track teams still able to set records in Manistique
May 7, 2015 MANISTIQUE — Shorthanded due to some members attending another school event, the Marquette Senior High School track teams still were able to set four school records at the Manistique Invitational on... more »»
Emeralds shut down Gwinn
May 7, 2015 GWINN — Manistique shut out the Gwinn Modeltowners, 24-0 and 16-0, in high school softball action on Tuesday. more »»
WIN battle royale
May 6, 2015 NEGAUNEE — Tuesday afternoon served as the first helping of a healthy dose of competition between the Negaunee and Ishpeming track teams this week. more »»
Violetta knocks in sweep-clinching run for Miners
May 6, 2015 NEGAUNEE — Nicole Violetta knocked in the game-winning run to complete a sweep by her Negaunee High School softball team over visiting Iron Mountain at LaCombe Field on Tuesday. more »»
Hawks boys win one for late coach
May 6, 2015 PERKINS — There was a bit of special motivation coming into Tuesday's Mid Peninsula Small School Invitational track meet for the Republic-Michigamme boys. more »»
Immel named to MHSAA council
May 6, 2015 MUNISING — An accomplished Munising High School athlete, Marissa Immel will be adding to her resume an advisory position with the Michigan High School Athletic Association. more »»
Houghton claims sweep at Noon Kiwanis golf invitational
May 6, 2015 CHAMPION — Houghton High School claimed both the boys and girls titles at the Noon Kiwanis Club Invitational golf meet hosted by Negaunee Tuesday at the Wawonowin Country Club. more »»
Munising edges Gwinn
May 6, 2015 GWINN — Munising High School's boys tennis team did just enough Tuesday to beat host Gwinn in a dual meet, 4-3. The Mustangs dominated the doubles competition and got a win from Jared Immel at No. more »»
Patriots charge past Knights
May 5, 2015 ISHPEMING — With the help of two Norway forfeits and a default, the Westwood High School boys tennis team posted an 8-0 win Monday over the visiting Knights. more »»
Marquette softball wins on road in Rapid River
May 5, 2015 RAPID RIVER — A pair of Marquette pitchers made hits a little hard to come by for the Rapid River Rockets Monday as they dropped 7-1 and 3-1 softball decisions to the Redettes. more »»
Westwood softball sweeps Negaunee
May 5, 2015 TILDEN TOWNSHIP — An 8-1 win over visiting Negaunee in the second game of a doubleheader gave the Westwood girls softball team a sweep Monda. more »»
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