text:
[Mental disorders in patients with fibromyalgia syndrome : Screening in centres of different medical specialties.]
ABSTRACT BACKGROUND: Systematic reviews have reported a wide range of prevalence rates for depressive, anxiety and posttraumatic stress disorders (PTSD) in patients with fibromyalgia syndrome (FMS) which have been partially explained by setting differences. No data are currently available on the prevalence of potential mental disorders depending on the medical specialty in Germany. MATERIAL AND METHODS: All consecutive FMS patients of 8 study centres (3 rheumatology/orthopaedic surgery, 3 psychosomatic/pain medicine, 2 physical/integrative medicine) were assessed from February 1 to July 31, 2012 with standardised questionnaires. Patients with FMS diagnosed by a study physician were included. Non-German speaking and mentally retarded patients were excluded. The German version of the Patient Health Questionnaire 4 was used to screen for potential depressive and anxiety disorders. Severe life events were assessed by the trauma list of the Munich Composite International Diagnostic Interview and symptom criteria of PTSD of the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) using the Posttraumatic Diagnostic Scale. RESULTS: Of 538 patients, 396 patients (93.9 % women, mean age 52.3 years, mean duration since chronic widespread pain 12.8 years, mean duration since FMS diagnosis 4.5 years) were analysed. In all, 65.7 % of patients met the criteria of a potential depressive disorder, 67.9 % of a potential anxiety disorder and 45.5 % of a potential PTSD. Potential depressive disorders were more frequent in the psychosomatic/pain medicine setting than in the rheumatology setting. CONCLUSION: Potential mental disorders were frequent in FMS patients regardless of the medical specialty. All FMS patients of all types of clinical settings should be screened for mental disorders.
Full-textDOI: · Available from: Winfried Häuser, Jan 19, 2014
- SourceAvailable from: Winfried Häuser
- "Please cite this article as: Häuser W, et al, Construct validity and clinical utility of current research criteria of DSM-5 somatic symptom disorder diagnosis in patients with ..., J Psychosom Res (2015), http://dx.doi.org/10.1016/j.jpsychores.2015.03.151 in previous German FMS multicenter studies [34] as well as of systematic reviews on FMS and mental disorders [35]. "
Article: Construct validity and clinical utility of current research criteria of DSM-5 Somatic Symptom Disorder diagnosis in patients with fibromyalgia syndrome[Show abstract] [Hide abstract]
ABSTRACT: The validity and clinical utility of current research criteria of the DSM 5 category somatic symptom disorder (SSD) needs to be tested outside the setting of psychiatry. Consecutive patients with an established diagnosis of fibromyalgia syndrome (FMS) were evaluated by medical examination, psychiatric interview and self-report questionnaires in an outpatient pain medicine center. The diagnosis of SSD was established using published research criteria. The discriminative concurrent criterion validity of SSD was tested by comparing FMS-patients with and without SSD as to the amount of impairment and of health care seeking. Two clinicians blinded as to the purpose of the study, assessed the medical reports of patients after the evaluation for the determination of the need for psychotherapy based on the German FMS - guideline recommendations (clinical utility). 25.6% of 156 patients met the criteria of SSD. Patients meeting SSD criteria scored significantly higher in a self-report measure of disability. There were no significant differences in the number of patients on sick leave or applying for disability pension and in self-reported doctor visits and physiotherapy in the previous six months. 95.0% of patients with SSD and 71.6% of patients without SSD met the criteria of a current anxiety or depressive disorder as assessed by the psychiatric interview. 80.0% of patients with SSD and 66.7% of patients without SSD received a recommendation for psychotherapy. The construct validity and clinical utility of current research criteria of DSM 5 category SSD were limited in German patients with FMS. Copyright © 2015 Elsevier Inc. All rights reserved.Journal of psychosomatic research 03/2015; 78(6). DOI:10.1016/j.jpsychores.2015.03.151 · 2.74 Impact Factor
Article: Patient Health Questionnaire 15 as a generic measure of severity in fibromyalgia syndrome: Surveys with patients of three different settings[Show abstract] [Hide abstract]
ABSTRACT: Objective Graduated treatment of patients with functional somatic syndromes (FSS) and fibromyalgia syndrome (FMS) depending on their severity has been recommended by recent guidelines. The Patient Health Questionnaire 15 (PHQ 15) is a validated measure of somatic symptom severity in FSS. We tested the discriminant and transcultural validity of the PHQ 15 as a generic measure of severity in persons with FMS. Methods Persons meeting recognized FMS-criteria of the general German population (N = 98), of the US National Data Bank of Rheumatic Diseases (N = 440), and of a single German pain medicine center (N = 167) completed validated self-report questionnaires on somatic and psychological distress (Polysymptomatic Distress scale, Patient Health Questionnaire 4), health-related quality of life (HRQOL) (Short Form Health Survey 12 or 36) and disability (Pain Disability Index). In addition, self-reports of working status were assessed in the clinical setting. Overall severity of FMS was defined by PHQ 15 scores: mild (0–9), moderate (10–14) and severe (15–30). Results Persons with mild, moderate and severe FMS did not differ in age and gender. Irrespective of the setting, persons with severe FMS reported more pain sites, fatigue, depressed mood, impaired HRQOL and disability than persons with moderate or mild FMS. Patients with severe FMS in the NDB and in the German clinical center reported more work-related disability than patients with mild FMS. Conclusion The PHQ 15 is a valid generic measure of overall severity in FMS.Journal of psychosomatic research 04/2014; 76(4). DOI:10.1016/j.jpsychores.2014.01.009 · 2.74 Impact Factor


text: We stayed just 1 night in Leeuwarden in the WestCord Hotel. Is was quiet, very clean and very comfortable. The room was very large and with a lot of space to leave your things. The breakfast-buffet on the 11th floor was very good, a excellent choice of evereything. The location is really out of town and we used our car... More

subset: commoncrawl


text:
I am selling a vintage brand new Canon Word Processor I bought it in 1998 which as far as I know is not found any more in the market other than used ones.
This WP would help prepare and store documents under absolute privacy without fears of being under any surveillance.
Here is the description of the CANON /WP "Start Writer -Jet 300"
Word Processor Canon Star Writer- Jet 300 Personal ...
Oct 7 -
Van Nuys - Computers & tech
This year's white iphone 5 with case.
Oct 7 -
Pasadena - Cell phones
GENUINE AUTHENTIC ORIGINAL Famous Name CONSUMER ELECTRONICS
WHOLESALE Famous Name CONSUMER ELECTRONICS; …EVERYTHING, FROM… INCLUDING… TO…
HD L.C.D. PLASMA and L.E.D. TELEVISION
CELL PHONE (BLACKBERRY, HTC, Google NEXUS, etc;)
MUSIC PLAYER (MP3/4/5/6, IPOD, etc;)
HOME HEALTH/ KITCHEN AIDES HOME ENTERTAINMENT ...and MORE...
As DIRECT DISCOUNT WHOLESALER, we are SUPPLIER ALSO of, TOP-BRAND, HIGH ...
Oct 7 -
Los Angeles - Other
LANIER 6713 Copier
It works good.
Sale is final.
Sold as is.
Oct 7 -
Palmdale - Computers & tech
BROTHER Intellifax 775 Plain Paper Fax, Phone and Copier.
The IntelliFax-775 packs lots of functionality in a compact, space saving design. Small enough to fit in cramped work spaces, this model is still able to accommodate a generous 100-sheet paper capacity.
This feature saves the expense of separate phone lines for fax and voice calls. A built-in interface even lets you connect an external ...
Swivel head tripod aluminum tripod, Lenmar stand
Velbon DF-60 swivel head adjustable tripod, adjustable stand. 747-888-4146
Oct 6 -
Calabasas - Photo & video
Security Camera Installation
Security camera is a prompt supplier of security cameras besides CCTV equipment that is CCTV for your office and home, they are usage to business and various work to use to Security Camera.
For more information about the Security Camera visit at:- https://www.audiovideoking.com/cctv-security-camera.php
Oct 6 -
Los Angeles - Other
NEW Canon EF 24-105mm f/3.5-5.6 IS STM
This is a NEW Canon EF 24-105mm f/3.5-5.6 IS STM Lens
In the Box:
E-77 II 77mm Lens Cap
Lens Dust Cap E (Rear)
Warranty Card
Amazon Price: $599
B&H Price: $599
42nd St. Photo Price: $595
I am selling it for $500! For any questions feel free to ask!
EF Mount Lens/Full-Frame Format
Two Aspherical Elements & One UD Element
Optimized Lens ...
Oct 5 -
Los Angeles - Photo & video
HP 56 & 57 injet cartridges (4)
HP 56 (1) black & 57 (3) tri color (1 HP and 2 remanufactured) retails for over $149 priced to sell at $25.00 all are new (printer broke after purchasing cartridges) fit HP Photosmart 7960, 7150, 7260, 7350, 7450, 7550, 7660, 7755, 7760 HP Deskjet 450 cbi, 450 ci, 450wbt, 5150, 5550, 5551, 5650, 5850, 9650, 9670, 9680 HP OFFICEJET 4110, 4110v, 4110xi, 4215, 4215xi, 5500 SERIES, 5505, 5510, ...
Oct 5 -
Hermosa Beach - Computers & tech
Samsung HDTV tuner
This Samsung DTV / HDTV standalone tuner is great for use with
video or computer monitors (w/o a tuner) or projectors. Comes with remote control model SIR-T451. Has analog + DVI (HDMI) outputs
Oct 5 -
Santa Monica - Photo & video
RENT a Projector & Screen for your events!
You can rent a complete presentation outfit, which includes the projector, screen, and audio. Great for parties, art shows, meetings, etc.
Oct 5 -
Santa Monica - Other
Olympus C8080 Digital Camera
This fine advanced point & shoot has a 5X (28-140mm) very sharp lens,
flash, 2 batteries, CF cards, charger, has 8MP CCD, in superb condition.
Rent a Projector + Screen for PC or Mac presentation
We can RENT you a projector-only, or a complete system...easy to use
this will make your PC or Mac images available to a large group!
Oct 5 -
Santa Monica - Computers & tech
Rent a Projector + Screen for your party or meeting
We can provide a complete RENTAL system with screen & audio for your event. This setup is good for 20 people, with larger systems available. Can be used with DVD/cable/sat/PC or Mac. Very easy to use!
Nintendo Wii White Console (NTSC)Balance Board,Kinect Games & Many Acc
Used: An item that has been used previously. The item may have some signs of cosmetic wear, but is fully operational and functions as intended. This item may be a floor model or store return that has been used. See the seller's listing for full details and description of any imperfections
This auction will include the following items
1 Nintendo wii console white
1 Nintendo wii balance ...
Oct 4 -
Long Beach - Video games
Microsoft Xbox 360 S with Kinect Bundle Games (NTSC)
Used: An item that has been used previously. The item may have some signs of cosmetic wear, but is fully operational and functions as intended. This item may be a floor model or store return that has been used. See the seller's listing for full details and description of any imperfections.
For as is seen in pictures for sale is the Microsoft Xbox 360 with Kinect Sensor Black Console
2 12inch pioneer champion series
2 12inch pioneer champion series speakers with bass control 1500 watt amp with the wires i used all good condition. You can try before you buy price is negotiable
Oct 4 -
Lancaster - Other
17 inch Apple MacBook Pro Lap top(2008)
17 inch Apple MacBook Pro,2008 laptop is sale
17 inch Apple MacBook Pro,Early 2008
Processor 2.6 GHz Intel Core 2 Duo
Memory 4 GB 667 MHz DDR2 SDRAM
Graphics NIVIDIA GeForce 8600M GT 512 MB
Software OS X 10.8.5.(12F4S)
Hard 1T(1000 GB)
You will receive what you see in the pictures.
Has no box.
***I do not do shipping please do not contact if you are in ...
Oct 4 -
Glendale - Computers & tech
Samsung 32" LED Smart HDTV 1080p
Nothing is wrong with it. Connects to the internet, apps, great for gaming
Oct 4 -
Pasadena - Other
Minolta AF50 1.4 lens, Sigma Zoom 28-200, Minolta Maxxum 7000 +more
--Minolta Maxxum AF 50mm 1:1.5 (22) lens with case............................................... $195 OBO
"Mint Condition" lens gives clearer/sharper pictures than the 1:1.7 (22) lens!
--Canon 49mm Skylight 1-A filter............................................................ $5
--Vivitar 49mm Circ. Polarizing filter....................................................... $10
--Sigma Zoom ...
Oct 3 -
Thousand Oaks - Photo & video


text: Hot Dog Tea Cosy by Ulster Weavers £12$26€17.75$19.74 4 customer reviews(4) In stock free gift wrap £6.95$15.06€10.28$11.43 delivery to United States Receive this item 5-10 working days from dispatch International delivery available quantity by Ulster Weavers Location: Antrim, GB read seller's profile see seller's complete range more items from this seller Hot Dogs Cotton Apron £16$34.67€23.67$26.32 Hot Dogs Cotton Tea Towel £7.50$16.25€11.09$12.33 Hound Dog Tea Cosy £12$26€17.75$19.74 Hot Dogs Double Oven Glove £13$28.17€19.23$21.38 Hot Dogs Gauntlet £12$26€17.75$19.74 Plain Dyed Grey Cotton Apron £16$34.67€23.67$26.32 view all you may also like PRODUCT DETAILS CUSTOMER REVIEWS DELIVERY RETURNS free gift wrap ask seller a question save for later An Ulster Weavers design. Cotton Tea Cosy with polyester wadding. Machine washable. Size: 35 x 27 cm. product code: 170884 4 customer reviews Wed 02 Jul 2014 Good quality Sat 21 Jun 2014 love this tea cosy just what I was looking for. Mon 06 Jan 2014 Fast delivery Tue 26 Nov 2013 No comment supplied. see all customer reviews hide some customer reviews read about our product rating system ratings guide trusted independent customer feedbackforum excellent bad good poor This product is dispatched to you by Ulster Weavers. MAINLAND UK order now and receive this item by price Standard Delivery Monday 12 October £1.75$3.79€2.58$2.87 Tracked Next Day Delivery Friday 9 October £6.70$14.51€9.91$11.02 NON-MAINLAND UK estimated delivery price Highlands & Islands of Scotland 2-5 working daysfrom dispatch £1.75$3.79€2.58$2.87 Northern Ireland 2-5 working daysfrom dispatch £1.75$3.79€2.58$2.87 Other UK Islands 2-5 working daysfrom dispatch £1.75$3.79€2.58$2.87 INTERNATIONAL DELIVERY estimated delivery price Western Europe 2-5 working daysfrom dispatch £5.00$10.83€7.39$8.22 Rest of Europe 5-10 working daysfrom dispatch £5.00$10.83€7.39$8.22 USA & Canada 5-10 working daysfrom dispatch £6.95$15.06€10.28$11.43 Asia & Australasia 5-10 working daysfrom dispatch £7.25$15.71€10.72$11.92 Rest of the world 5-14 working daysfrom dispatch £7.25$15.71€10.72$11.92 You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Ulster Weavers's return policy


text:
Hilton Hotels And Resorts Millington hotels are listed below. Search for cheap and discount Hilton Hotels And Resorts hotel rates in Millington, TN for your upcoming individual or group travel. We list the best Hilton Hotels And Resorts Millington venues so you can review the Millington Hilton Hotels And Resorts hotel list below to find the perfect place.
This page will show you discounted Millington, TN hotels + motels that have similar quality of Hilton Hotels And Resorts.Booking a group or meeting? Set up a group hotel block in Millington TN
How should we direct your call?
Located in Cordova, Hilton Garden Inn Memphis/Wolfchase Galleria is in a rural location and convenient to Bellevue Baptist Church and Wolfchase Galleria.


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Donald Trump Has the Republican Party in the Palm of His Hand
September 04, 2015
The only question now is: Will he blow out his competition, or will Ben Carson make it competitive?
Tonight's Republican Debate Is the Party's Worst Nightmare
August 06, 2015
The circus is back in town, despite the GOP's promise to learn from the 2012 disaster.
Why the RNC May Regret Picking Cleveland for 2016
July 08, 2014
When the party convenes in 2016, there's going to be one extra elephant in the room.
All The President's Hor D'Oeurves
April 27, 2011
A huge, huge announcement, per Mike Allen's Playbook, about Politico's plans to participate in, cover, and generally win the White House Correspondents Association annual bacchanalia: POLITICO UNVEILS WHITE HOUSE CORRESPONDENTS' DINNER GUEST LIST, EVENT DETAILS AND COVERAGE PLANS -- Some guest highlights: Musician John Legend; Texas Gov. Rick Perry; designer Tory Burch; Rep. Anthony Weiner and Huma Abedin, top aide to Secretary of State Clinton; comedian Joan Rivers; financier T.
One-Armed Midgets, Rejoice!
October 06, 2010
The months leading up to an election always involve a rush of frantic activity. There are key states to visit and swing voters to court. And so, late this summer, Michael Steele was paying timely visits to crucial battlegrounds . . . in Guam, the U.S. Virgin Islands, Puerto Rico, and the Northern Mariana Islands. Perhaps those aren't considered key states in the elections that most Republicans care about, the 2010 midterms.
The Tea Party Glossary
February 03, 2010
Here's one thing about the Tea Party movement everyone can agree on: It's confusing. With decentralization as a core value, the Tea Party phenomenon can seem like a baffling collection of individuals and organizations, often divided against each other. But with its first national convention now underway in Nashville, and as Tea Party groups gear up for campaigns around the country, it's time we met the movement's main players.
The Worst Of Michael Steele On Health Care
September 05, 2009
There are poor communicators, and then there is RNC Chairman Michael Steele. During the recess, Steele has been on something of a public-relations spree, attempting to promote the GOP's health care message on TV and in town halls, and leaving a trail of wreckage in his wake. Click through this video slideshow to see some of Steele's worst health care messaging. During Steele's recent talk at Howard University, a woman stood to explain that she supports health care reform because her mother died of cancer.
The Worst Of Michael Steele On Health Care
September 04, 2009
There are poor communicators, and then there is RNC Chairman Michael Steele. During the recess, Steele has been on something of a public-relations spree, attempting to promote the GOP's health care message on TV and in town halls, and leaving a trail of wreckage in his wake. Click through this video slideshow to see some of Steele's worst health care messaging.
Now the GOP Loves Medicare? It's So Hard to Keep Track...
August 24, 2009
Harold Pollack is a professor at the University of Chicago School of Social Service Administration and Special Correspondent for The Treatment. In this morning's Washington Post, RNC chairman Michael Steele weighs in with what he modestly calls a "Seniors' Health Care Bill of Rights." Continuing on the death panel theme, Steele comes out against various mythical rationing measures no Democrat proposes or supports.
September 24, 2007
If, several decades from now, anthropologists set out to locate the spiritual hub of early twenty-first-century Washington, they could do worse than the Caucus Room, that bunker of a steakhouse across from the FBI building downtown. Founded seven years ago by a bipartisan klatch of moneymen and influence-peddlers--among them, famed lobbyist Tommy Boggs, Bush-family henchman C. Boyden Gray, and Clinton fund-raiser Terry McAuliffe--the restaurant caters to the bland appetites and bulging egos of Washington's expense-account elite.


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Microtel Inn And SuitesJuly 5, 2013Hotel • Uncasville, United States
Room smells like a sweaty fat person
Room smells like a sweaty fat person
Tom at the bar is the man - treat him well
Hot and sour soup with Chicken and Pad Thai w tofu are both excellent
Nice shot into the par 3 third over the water - stuck it to 10 feet.... Missed the putt womp
Get your falafel spicy
Fuck the belt!! Shittiest highway in America
Chicken Cutlet, Roasted Red Peppers, Fresh Mozz - Bang
Bloody Sundays - Amazing Bloody Marys. Great food as well - little cramped if you sit in the back the waiters for the outside tables keep leaving the doors open and it gets cold but i love this place
Stir fry is fire. Get the Black Bean and Ginger sauce with some spicy sauce
Roast Pork with yellow rice and black beans - 9 bucks for lunch, cant beat it. Plus it is mad good
BBQ Chicken and Garlic Chicken with Brown Rice - do it
Number 6 dbl box with bulgi and dak bulgi with a side of kimchi is awesome. Lots of food for 10 bucks - the glass noodles are good and ask for extra spicy sauce
The Chicken parm hero is bomb
Front desk people are awesome. Get to know them if you will be here for a lengthy period of time


text:
Please Join NY/NJ Baykeeper on Wednesday, October 28th 6:30-9:00pm at the Keyport Yacht Club, 115 1st Street, Keyport, New Jersey as we honor our 2015 Honorees! Click here to purchase tickets to the 2015 Awards Reception Click here to place in Ad in our Event Journal To purchase tickets please click here. All artwork to advertise in our Event Journal must be received by 10/13. Please click here to place an Ad in our event journal. Pricing is as follows: 1/4 page (B&W) $100 1/2 page (B&W) $200 Full Page (B&W) $300 Inside Back Cover (Color) $500 Inside Front Cover Read more →
Governor Christie Pocket Vetoes S.831: Sewage Right to Know Bill
We are very disappointed that Governor Christie does not care if you fish, swim, kayak, or play in raw sewage. Governor Christie declined to sign S.831: Sewage Right to Know Bill before it expired this week. The Sewage Right to Know bill would have alerted New Jersey residents when raw sewage is in our local waters so we can protect our health. The bill had broad bi-partisan support and passed by a landslide in the Legislature. The EPA estimates that 23 billion gallons of sewage overflow every year but New Jersey residents will not be alerted thanks to the Governor's veto. We continue...Read More


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All Tournament Teams
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Welcome to the 2015-16 Season!
2015 ASL Club Champions
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Major League Baseball will hold day one of the 2014 First-Year Player Draft on Thursday, June 5th in New Jersey.
Click here for the original story.
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text: More from SI Report: Dodgers release pitcher Freddy Garcia Report: Dodgers release pitcher Freddy Garcia Marshawn Lynch sports gold cleats for Super Bowl Marshawn Lynch sports gold cleats for Super Bowl Louisville vs. FIU: Game time, live stream, TV coverage Louisville vs. FIU: Game time, live stream, TV coverage Pittsburgh-area high school football player dies after... Pittsburgh-area high school football player dies after... Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Kurt Busch's team owner frustrated with outbursts, sponsor struggles by Alexander Abnos Twitter Email Posted: Tue Jun. 5, 2012 Kurt Busch has found himself in hot water with his owner after his most recent outburst. (Todd Warshaw, Getty Images)Kurt Busch hasn't won many new fans over the past several months, with a series of wrecks, disputes, and outbursts tainting his image. Now it appears even the president of his team is getting fed up. NASCAR suspended Busch for a week yesterday after threatening a reporter at Dover over the weekend, in addition to extending his probation to the end of the year. Phoenix Racing owner James Finch expressed his frustrations and urged Busch to get back on track today in an interview with SiriusXM's NASCAR channel, published in USA Today."Here's the deal: Quit wrecking the cars, get a good finish, be nice to people. That's not real hard to do."Finch also intimated that Phoenix is having trouble getting sponsors because of Busch's repeated bad behavior."It's affecting me. If I can't get a sponsor, I can't keep running without a sponsor," Finch said. "That's a slow death. I don't want to do that."Hopefully if we can get Kurt's mind right, we can win some races. If we can't get his mind right so we can race into the future, then I'll go do something else. It's just that simple."Busch joined Phoenix Racing this year after parting company with Penske Racing after the 2011 season. Busch's split with Penske came after another verbal tirade at a report, this time ESPN's Jerry Punch. Promoted Stories Comments


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Invading France
I know its a bit of a silly name for this blog entry, especially given that we've already been in France for a few days, but since the things that we saw around Normandy basically revolved around invading France, I thought it was still appropriate enough. We finished up in Arras and drove the hire car south to stay in Caen for two nights. We got …
William, Harold & the Final Dimanche Roast... Boo!
After the cathedral, we went to the tapestry museum. Again, Jon waited whilst I went in (his insistence!) What a joy and a wonder! I remember learning about the Bayeux Tapestry at school and drawing Harold with his arrow in his eye. To stand and see the actual cloth... It was an amazing moment. The museum is so well done. The tapestry is stretched out in a darkened corridor, illuminated behind glass. Each visitor has an audio guide ...
Caen the Giants
... I am dumbfounded by it.
One aspect of Europe that has virtually no parallel in Australia is the many, many layers of recorded history: in the same location. This was so starkly portrayed in our visit to nearby Bayeaux, home of the famous Bayeux tapestry. In 1066, William, Duke of Normandy, took the English throne and is now better known from that very battle as William the Conqueror.
These events were depicted in ...
Back to 1944
... of.
Word for 6/6: Tapestry
For this little bit, I'm handing over to Jason, who has proven to be a pretty good writer and editor, for our entries so far - not that I'm bored of writing to you all, just that while I continued unpacking and cleaning, he was out adventuring and that makes for a much better read!
As i left Rebecca to unpack her bag into the tiny little cupboards in Lars (our camper ...
... pretty incredible to see and climb through the enormous impressions left by the Allies' air raid bombings. The views over the cliffs were breathtaking, and even more impressive is the feat that the outnumbered American troops achieved: scaling said cliffs with ropes and ladders under heavy artillery fire to defeat the Nazis. On a lighter note, we decided to break up our somber sightseeing with a calvados (apple ...


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I missed my morning "Kinection"
by Iris Harrison
posted Jan 19 2011 2:28PM
Okay, I confess, this morning I had an early doctor appointment and didn't get in my usual Kinect for X Box 360 "play time" before coming to the station. And you know what? I feel out of sorts…and kind of guilty. I feel like something's missing. Kind of pissy too. It's like being a kid in elementary school and not having recess. Not good! Pent up energy usually works itself out in a bad way unless there's a constructive release. But in a way, this experience is good because it shows me that I need to get up and do that morning physical activity to really start my day in a better way. So, now…I can't wait to get home and do some Zen stretching with the Kinect Your Shape Fitness program. Then maybe I'll dance. My dance instructor on the program assures me that I'm pretty good, or at least that's what he keeps saying. Or maybe I can get Marty to play a game of beach volleyball with me. I'm horrible at that game, but it's fun! That's the thing about the Kinect Good for you games, they're just so much fun, and I've promised myself to get stronger and more flexible by this summer. My doctor is all in favor of it too. Tomorrow, I won't miss my morning play time. Hey, wouldn't life be better if we all had Kinect at work to work out our stress? Then I vote for a nap.
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I missed my morning "Kinection"
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Community Participation
Tuesday, August 25, 2015
The Chairman, Mr. Winston Wellington, was a presenter at the Revival All-Age School's Career's Day. Students role play different professionals, e.g. the doctor, nurse, policeman/woman, fireman/woman, pastor, etc. During this session he implored the students to be the best at whatever career they may choose ...
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Publications (24)116.64 Total impact
Article: β-catenin mutation is correlated with a favorable prognosis in patients with hepatocellular carcinoma[Show abstract] [Hide abstract]
ABSTRACT: The β-catenin gene is frequently mutated in patients with hepatocellular carcinoma (HCC) and has long been thought to be one of the major oncogenes involved in the hepatocarcinogenesis. The prognostic role of β-catenin mutation in HCC remains unclear. To address this issue, a search for relevant studies was performed in the PubMed, Embase and Web of Science databases. The pooled effect was calculated from the available data to evaluate the correlation of β-catenin mutation with overall survival rate and tumor clinicopathological features in patients with HCC. The pooled odds ratio (OR) was calculated using the Mantel-Haenszel model for fixed effects. Three studies met the inclusion criteria. A total of 618 cases were included, and β-catenin mutation was identified in 104 of them. The meta-analysis revealed that the presence of β-catenin mutation (n=104), compared with the control group (n=514), was correlated with a longer overall survival rate [OR, 0.33; 95% confidence interval (CI), 0.21-0.53; P<0.00001] in patients with HCC. No significant heterogeneity was found among the eligible studies (I(2)=0%; P=0.72). β-catenin mutation was correlated with a relatively lower rate of hepatitis B virus infection (OR, 0.36; 95% CI, 0.21-0.61; P=0.0002), improved tumor differentiation (OR, 0.32; 95% CI, 0.19-0.56; P<0.0001) and a lower tumor-node-metastasis stage (I+II) (OR, 0.23; 95% CI, 0.14-0.38; P<0.00001). These findings suggest that β-catenin mutation may predict a favorable prognosis in patients with HCC.Molecular and Clinical Oncology 07/2015; 3(4):936-940. DOI:10.3892/mco.2015.569
Article: MicroRNA-26a Suppresses Angiogenesis in Human Hepatocellular Carcinoma by Targeting Hepatocyte Growth Factor-cMet Pathway[Show abstract] [Hide abstract]
ABSTRACT: Unlabelled: MicroRNA (miR)-26a can suppress tumor growth and metastasis of hepatocellular carcinoma (HCC). Since angiogenesis is important for tumor growth and metastasis, we investigated the possible roles of miR-26a in tumor angiogenesis. Down-regulation of miR-26a was found to correlate with an increased angiogenic potential of HCC. Through gain- and loss-of-function studies, miR-26a was demonstrated to significantly inhibit vascular endothelial growth factor A (VEGFA) expression in HCC cells and then suppress the promoting effects of HCC cells on in vitro proliferation, migration, and capillary tube formation of endothelial cells, as well as in vivo tumor angiogenesis of HCC. Hepatocyte growth factor (HGF) was identified as a target of miR-26a. HGF simulation antagonized the effects induced by miR-26a up-regulation. In contrast, silencing HGF induced similar effects to miR-26a. We further found that miR-26a exerted its antiangiogenesis function, at least in part, by inhibiting HGF-hepatocyte growth factor receptor (cMet) and its downstream signaling pathway, in turn, suppressing VEGFA production in HCC cells and impairing VEGFR2-signaling in endothelial cells. HCC patients who had high miR-26a, low HGF, low VEGFA, or low microvessel density (MVD) in tumor tissues had a better prognosis with longer overall survival (OS) and time to recurrence (TTR). In multivariate analysis, miR-26a, or in combination with HGF, was demonstrated to be an independent prognostic indicator for OS and TTR of HCC patients. Conclusion: miR-26a could suppress tumor angiogenesis of HCC through HGF-cMet signaling, and it is a new hopeful therapeutic target and prognostic marker for HCC.Hepatology 05/2014; 59(5). DOI:10.1002/hep.26941 · 11.06 Impact Factor
Article: Genomic Aberrations in the HTPAP Promoter Affect Tumor Metastasis and Clinical Prognosis of Hepatocellular Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: We previously reported that the intronic tagSNP +357G/C in the metastasis suppressor HTPAP is associated with metastasis and prognosis of hepatocellular carcinoma (HCC). The aim of this study was to investigate whether SNPs in the HTPAP promoter modulate HTPAP expression and prognosis of HCC. Genomic DNA from 572 microdissected HCCs were genotyped by pyrosequencing and verified by direct sequencing. Haplotype blocks were analyzed. Reporter plasmids were constructed and transfected into HCC cell lines. Transcriptional activities of plasmids were analyzed by dual-luciferase reporter systems. HTPAP expression was measured by real-time quantitative PCR, western blots, and tissue microarrays. Invasion was assessed by Matrigel assays. The prognostic values of HTPAP promoter SNPs in HCC were evaluated by Kaplan-Meier and Cox regression analyses. We identified six SNPs, including -1053A/G and +64G/C, in the HTPAP promoter. The SNPs were in complete linkage disequilibrium, resulting in three promoter haplotypes (promoter I:-1053AA/+64GG, promoter II: -1053AG/+64GC, and promoter III: -1053GG/+64CC). Promoter I manifested the highest luciferase index (p<0.005). However, no significant difference was observed between promoters II and III. We consistently found that HTPAP mRNA and protein levels were significantly higher in promoter I than that of promoter II+III (p<0.001). Invasion was increased in HCC cells transfected with promoters II+III compared to those transfected with promoter I (p<0.05). The HTPAP promoter II+III haplotype was associated with significantly increased metastasis compared to that of promoter I (p = 0.023). The postoperative five-year overall survival of patients with promoters II+III was lower than that of patients with promoter I (p = 0.006). Multivariate analysis showed that the promoter II+III haplotype was an adverse prognostic marker in HCC. The genetic variants at loci -1053 and +64 of the HTPAP promoter affect the expression of HTPAP, which might be a novel determinant and target for HCC prognosis.PLoS ONE 03/2014; 9(3):e90528. DOI:10.1371/journal.pone.0090528 · 3.23 Impact Factor
Article: Correlation and prognostic value of osteopontin and Bcl-2 in hepatocellular carcinoma patients after curative resection[Show abstract] [Hide abstract]
ABSTRACT: Osteopontin (OPN) may facilitate tumorigenesis and metastasis through prevention of tumor cells from apoptosis. Although previous studies have suggested involvement of enhanced Bcl-2 protein family expression, the role of OPN together with Bcl-2 in hepatocellular carcinoma (HCC) remains unknown. In this study, we used western blotting to detect the OPN and Bcl-2 expression levels in cell lines with different OPN backgrounds and HCC tissues, and tumor tissue microarrays to examine OPN and Bcl-2 expression levels in 454 HCC cases. The Kaplan-Meier method and log-rank test were applied to investigate the predictive values of OPN and Bcl-2 in HCC patients. In vitro assays indicated that OPN expression increased concordantly with increasing metastatic potential in MHCC97-H, MHCC97-L, HepG2 and SMMC-7721 cell lines by western blotting, whereas Bcl-2 expression declined. In addition, Bcl-2 was highly upregulated in OPN knockdown MHCC97-H cell lines. Furthermore, in HCC tissues, it was confirmed that OPN levels were also significantly higher in recurrent tumor tissues compared to non-recurrent tissues by western blotting (p<0.001), whereas the contrary occurred in Bcl-2 (p=0.046). Using immunohistochemistry analysis, patients with higher OPN levels had significantly shorter median survival time and recurrence time compared to the lower ones, although the opposite occurred in Bcl-2 levels. Of note, when OPN and Bcl-2 were combined, we found that the co-index of OPN/Bcl-2 was an independent prognostic factor for both overall survival (p<0.001) and time to recurrence (p<0.001). Our findings demonstrate that OPN/Bcl-2 expression is a promising independent predictor of recurrence and survival in HCC. Additionally, Bcl-2 levels may be regulated by OPN in the HCC microenvironment.Oncology Reports 09/2013; 30(6). DOI:10.3892/or.2013.2737 · 2.30 Impact Factor
Article: MicroRNA-26a Suppresses Tumor Growth and Metastasis of Human Hepatocellular Carcinoma by Targeting Interleukin-6-Stat3 Pathway[Show abstract] [Hide abstract]
ABSTRACT: Unlabelled: Down-regulation of microRNA-26a (miR-26a) is associated with poor prognosis of hepatocellular carcinoma (HCC), but its functional mechanism in HCC remains unclear. In this study, we investigated the roles of miR-26a in tumor growth and metastasis of HCC and found that miR-26a was frequently down-regulated in HCC tissues. Down-regulation of miR-26a correlated with HCC recurrence and metastasis. Through gain- and loss-of-function studies, miR-26a was demonstrated to significantly inhibit in vitro cell proliferation, migration, and invasion. In addition, miR-26a induced G1 arrest and promoted apoptosis of HCC cells. Importantly, miR-26a suppressed in vivo tumor growth and metastasis in nude mice models bearing human HCC. Interleukin-6 (IL-6) was identified as a target of miR-26a. Knockdown of IL-6 induced effects on HCC cells similar to those induced by miR-26a. In contrast, IL-6 treatment abrogated the effects induced by miR-26a up-regulation. Moreover, miR-26a dramatically suppressed expression of signal transducer and activator of transcription 3 (Stat3) target genes, including Bcl-2, Mcl-1, cyclin D1, and MMP2. IL-6 treatment antagonized this effect, while knockdown of IL-6 by IL-6 short hairpin RNA (shIL-6) induced inhibitory effects on the expression of p-Stat3 and its main target genes, similar to miR-26a. The messenger RNA and protein levels of IL-6 inversely correlated with miR-26a in HCCs. Patients with high miR-26a or low IL-6 in HCC tissues had a better prognosis with longer overall survival (OS) and time to recurrence (TTR). In multivariate analysis, miR-26a, IL-6, and their combination were demonstrated to be independent prognostic indicators for OS and TTR of HCC patients. Conclusion: miR-26a could suppress tumor growth and metastasis of HCC through IL-6-Stat3 signaling and is a novel prognostic marker and therapeutic target for HCC.Hepatology 07/2013; 58(1). DOI:10.1002/hep.26305 · 11.06 Impact Factor
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ABSTRACT: Purpose: To evaluate the value of serum midkine (MDK) as a diagnostic biomarker in hepatocellular carcinoma, particularly for those with negative alpha-fetoprotein (AFP) and at an early stage. Experimental design: MDK expression in tumors was assessed by immunohistochemistry from 105 patients with hepatocellular carcinomas or liver cirrhosis. Serum MDK levels were detected by ELISA in 933 participants including hepatocellular carcinomas and hospital controls from different medical centers. Sensitivities and specificities of serum MDK in diagnosing hepatocellular carcinoma according to AFP level and Barcelona Clinic Liver Cancer (BCLC) stage were analyzed. Results: MDK levels were significantly elevated in hepatocellular carcinoma tissues as well as serum samples. The sensitivity of serum MDK for hepatocellular carcinoma diagnosis was much higher than that of AFP (86.9% vs. 51.9%) with similar specificities (83.9% vs. 86.3%). Notably, serum MDK had an outstanding performance in distinguishing AFP-negative hepatocellular carcinomas from different controls: In those AFP-negative hepatocellular carcinomas, the sensitivity could reach as high as 89.2%. Moreover, receiver operating characteristic (ROC) curve analysis also showed that serum MDK had a better performance compared with AFP in distinguishing early-stage hepatocellular carcinomas as well as small hepatocellular carcinomas. Even in very early-stage hepatocellular carcinomas, MDK showed an obviously higher sensitivity compared with AFP (80% vs. 40%). Furthermore, serum MDK level was significantly decreased in patients with hepatocellular carcinomas after curative resection and re-elevated when tumor relapse occurred. Conclusions: Serum MDK is significantly elevated in most hepatocellular carcinomas, including those with negative AFP and at an early stage, which may serve as a novel diagnostic marker in early diagnosis and postoperative monitoring of hepatocellular carcinomas.Clinical Cancer Research 05/2013; 19(14). DOI:10.1158/1078-0432.CCR-12-3363 · 8.72 Impact Factor
Article: Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Unlabelled: Osteopontin (OPN) plays a crucial role in hepatocellular carcinoma (HCC) metastasis. However, little is known about the impact of OPN polymorphisms on cancer progression. In this study, we first identified the single nucleotide polymorphisms (SNPs) in the OPN promoter region by direct sequencing in 30 HCCs, and then evaluated the prognostic values of the selected ones in two large cohorts of 826 HCC patients. The identified SNPs were functionally analyzed using in vitro and in vivo assays and their correlations with OPN levels were also evaluated. Only SNP at locus -443 and their related haplotypes (Ht2: -1748A/-616G/-443T/-155* [*indicates base deletion]; Ht3: -1748A/-616G/-443C/-155*) were significantly associated with overall survival (OS) and time to recurrence (TTR). The patients with the -443TT/TC genotype or Ht2 had a shorter OS and TTR compared with those with -443CC genotype or Ht3. This was further confirmed in the validation cohort. Moreover, this correlation remained significant in patients with small HCCs (≤5 cm). Multivariate analyses indicated that the prognostic performance of the -443 genotypes (OS, P=0.031; TTR, P=0.005) and their related haplotypes (OS, P=0.002; TTR, P=0.001) was independent of other clinicopathological factors. The Ht2 and -443TT genotype could significantly increase the promoter transcriptional activity and expression level of OPN compared with the Ht3 or -443CC genotype, and lead to an obvious increase in both in vitro invasion and in vivo tumor growth and lung metastasis of HCC cells (P<0.05). Conclusion: The genetic variation at locus -443 of the OPN promoter plays important roles in the regulation of OPN expression and cancer progression of HCCs, which is a novel determinant and target for HCC metastasis and prognosis.Hepatology 03/2013; 57(3). DOI:10.1002/hep.26103 · 11.06 Impact Factor
Article: Mesenchymal stem cells seldomly fuse with hepatocellular carcinoma cells and are mainly distributed in the tumor stroma in mouse models[Show abstract] [Hide abstract]
ABSTRACT: Mesenchymal stem cells (MSCs) can have an effect on the growth and metastasis of human malignancies, including hepatocellular carcinoma (HCC); however, their mechanisms of action are not yet fully understood. The cell fusion of stem cell derived from bone marrow with other cells has been increasingly emphasized. The purpose of this study was to investigate the distribution of MSCs in mouse models of HCC, as well as the cell fusion between MSCs and HCC cells. We labeled HCC cells and MSCs with green fluorescence protein (GFP), red fluorescence protein (RFP), 4',6-diamidino-2-phenylindole (DAPI) and 5-bromo-2'-deoxyuridine (BrdU). We found that MSCs fused with HCC cells at a low frequency in vitro. MSCs were found to be merged into HCC tissues after intravenous injection, and compared with the mice not injected with MSCs, the MSCs were mainly distributed in the tumor stroma; Following the injection of the MSCs, the tumor stroma was found to have expanded in size, and the rate of pulmonary metastasis in the MSC-injected group was significantly lower (20%) compared to that in the group not injected with MSCs (100%, P=0.01). These data suggest that cell fusion between MSCs and HCC after engraftment is not one of the main mechanisms of action of the MSCs, while stromal differentiation is a major mechanism of action of the MSCs, leading to the inhibition of the pulmonary metastasis of HCC.Oncology Reports 12/2012; 29(2). DOI:10.3892/or.2012.2174 · 2.30 Impact Factor
Article: Postoperative Serum Osteopontin Level is a Novel Monitor for Treatment Response and Tumor Recurrence after Resection of Hepatitis B–related Hepatocellular Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Background: Presurgery serum osteopontin (OPN) level has been demonstrated to correlate to tumor recurrence and survival of hepatocellular carcinoma (HCC) patients. This study investigated the postoperative dynamic changes of serum OPN level and its clinical significance in HCC patients. Methods: Presurgery serum OPN levels were measured by enzyme-linked immunosorbent assay in cohort A of 179 HCC patients and were compared with the multiple controls including different kinds of liver diseases and healthy individuals. In cohort B of 110 patients with resectable HCCs, besides preoperative assays, serum OPN was monitored at 1 week, 1, and ≥2 months after operation. Results: The baseline presurgery serum OPN of HCC patients was significantly higher than that of the patients with the other kinds of liver diseases (p < 0.0001). The prognostic values of presurgery serum OPN level in HCC patients were further confirmed. The postsurgery OPN levels were significantly elevated within 1 week after HCC resection, then decreased at 1 month and reached the nadir later than 2 months after operations. It increased again at the time of tumor recurrence, then declined after the second removal of recurrent HCCs. Moreover, postoperative OPN in α-fetoprotein-negative and -positive HCC patients had the same changing pattern; it only correlated to liver function and C-reactive protein level. Conclusions: After a transient fluctuation, serum OPN levels significantly decrease after curative resection of HCCs. Postoperative serum OPN could serve as a surrogate serologic biomarker for monitoring treatment response and tumor recurrence after HCC resection, including α-fetoprotein-negative ones.Annals of Surgical Oncology 12/2012; 20(3). DOI:10.1245/s10434-012-2749-9 · 3.93 Impact Factor
Article: TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model[Show abstract] [Hide abstract]
ABSTRACT: Background Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma (HCC) is till unknown. Methods We detected the in vitro and in vivo expression levels of TGF β1/Smads by Real-time PCR and Western blot in MHCC97-H and MHCC97–L cell lines, which are HCC cell lines and have higher and lower pulmonary metastatic potential respectively. Results TGF β1 mRNA level in MHCC97-L tumors were higher than that in MHCC97-H tumors, (2.81±1.61 vs. 1.24±0.96, P=0.002), TGF β1 protein level in MHCC97-L tumors were also higher than that in MHCC97-H tumors (1.37±0.95 vs. 0.32±0.22, P<0.001). In addition, the TGF β1 mRNA level positively correlated with pulmonary metastasis, and the relations between TGF β1 and Smads were also found (R2=0.12 and 0.40, respectively). Conclusions Our results suggest that TGF β/ Smads promote pulmonary metastasis of HCC.Journal of Experimental & Clinical Cancer Research 11/2012; 31(1):93. DOI:10.1186/1756-9966-31-93 · 4.43 Impact Factor
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ABSTRACT: In the present study, we constructed a lentivirus vector encoding the miR-29a precursor and established two stably infected cell lines, PLC-29a and 97L-29a. The overexpression of miR-29a was confirmed by TaqMan RT-PCR and significantly suppressed the growth of the hepatocellular carcinoma cell lines MHCC-97L and PLC. Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected. Silencing SPARC expression by RNAi knockdown resulted in a similar effect as miR-29a overexpression on hepatocellular carcinoma (HCC) cell growth regulation. Anti-miR-29a oligonucleotides (AMOs) upregulated the levels of SPARC in the HCC cells. The phosphorylation of AKT/mTOR downstream of SPARC was inhibited in miR-29a-overexpressing HCC cells. We further examined and compared the expression levels of miR-29a in HCC tissues and the corresponding nearby non-cancerous liver tissues of 110 patients with HCC by qRT-PCR, and significantly lower expression of miR-29a was observed in the tissues affected by HCC. Our findings demonstrate that the expression of miR-29a is important in the regulation of the SPARC-AKT pathway and HCC growth.International Journal of Molecular Medicine 09/2012; 30(6). DOI:10.3892/ijmm.2012.1140 · 2.09 Impact Factor
Article: MicroRNA-29a-5p Is a Novel Predictor for Early Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma after Surgical Resection[Show abstract] [Hide abstract]
ABSTRACT: It is still difficult to predict the probability of tumor recurrence after resection of hepatocellular carcinoma (HCC). In this study, we set out to identify specific microRNA (miRNA) in microdissected hepatitis B virus (HBV)-related HCC tissue from formalin-fixed paraffin-embedded (FFPE) samples which might be used in predicting early recurrence after HCC resection. Taqman low density arrays were used to detect the 667 miRNA profiles in both the microdissected tumorous and adjacent non-tumorous liver tissues from 20 HCC patients (discovery set) including 10 patients with early tumor recurrence and 10 without early tumor recurrence and to identify the differentially expressed miRNAs related to HCC recurrence. Then quantitative real-time PCR (qRT-PCR) was used to verify the findings in 106 patients (training set), and to develop a predictive assay. The identified miRNAs were further validated in an independent cohort of 112 patients (validation set). Thirty seven miRNAs were identified from 20 HCC patients and validated in 106 HCC patients using qRT-PCR. A significant association was found between miR-29a-5p level in HCC tissues and early tumor recurrence (P = 0.0002). This association was further confirmed in the independent validation set of 112 patients (P = 0.0154). MiR-29a-5p level was significantly associated with both time to tumor recurrence (TTR) (P = 0.0015) and overall survival (OS) (P = 0.0079) in validation set. In the multivariate analyses, miR-29a-5p was identified as an independent factor for TTR, particularly for those patients with early stage of HCC. The sensitivity and specificity of miR-29a-5p for the prediction of early HCC recurrence of BCLC 0/A stage HCC were 74.2% and 68.2%, respectively. These suggest that miR-29a-5p might be a useful marker for the prediction of early tumor recurrence after HCC resection, especially in BCLC 0/A stage HCCs.PLoS ONE 06/2012; 7(12):e52393. DOI:10.1371/journal.pone.0052393 · 3.23 Impact Factor
Article: Anti-cancer effects of p21WAF1/CIP1 transcriptional activation induced by dsRNAs in human hepatocellular carcinoma cell lines[Show abstract] [Hide abstract]
ABSTRACT: To investigate the anti-cancer effects of p21WAF1/CIP1 transcriptional activation induced by dsRNAs in hepatocellular carcinoma (HCC) cell lines. HCC cell lines BEL7402, SMMC-7721, MHCC97L, MHCC97H, and MHCCLM3 were used. HCC cells were treated with dsP21-322 (50 nmol/L), dsControl (50 nmol/L), siP21 (50 nmol/L), or mock transfection. The expression of p21 was detected using quantitative PCR and Western blot. The effects of RNA activation on HCC cells were determined using cell viability assays, apoptosis analyses and clonogenic survival assays. Western blot was also conducted to detect the expression of Bcl-xL, survivin, cleaved caspase-3, cleaved caspase-9 and cleaved PARP. At 72 to 120 h following the transfection, dsP21-322 markedly inhibited the viability of HCC cells and clone formation. At the same times, dsP21-322 caused a significant increase in HCC cell apoptosis, as demonstrated with cytometric analysis. The phenomena were correlated with decreased expression levels of the anti-apoptotic proteins Bcl-xL, surviving, and increased expression of cleaved caspase-3, cleaved caspase-9 and cleaved PARP. RNA-induced activation of p21 gene expression may have significant therapeutic potential for the treatment of hepatocellular carcinoma and other cancers.Acta Pharmacologica Sinica 06/2011; 32(7):939-46. DOI:10.1038/aps.2011.28 · 2.91 Impact Factor
Article: Identification of Suitable Reference Genes for qRT-PCR Analysis of Circulating microRNAs in Hepatitis B Virus-Infected Patients[Show abstract] [Hide abstract]
ABSTRACT: Circulating microRNAs (miRNAs) were found to exist in serum/plasma in a highly stable, cell-free form, and aberrantly expressed in many human diseases. Currently, the expression levels of circulating miRNAs are estimated by quantitative real-time polymerase chain reaction. However, no study has systematically evaluated reference genes for evaluating circulating microRNA expression. This study describes the identification and characterization of an appropriate reference gene for the normalization of circulating miRNA levels in hepatitis B virus (HBV)-infected patients and healthy people. Ten miRNAs that resemble the mean expression of the TaqMan low density array together with U6, RNU6B, and miR-16 were validated with two algorithms, geNorm, and NormFinder, after ensuring their equivalent expression between the two study groups. The combination of miR-26a, miR-221, and miR-22* is recommended as the most stable set of reference genes for circulating miRNA evaluation in HBV patients and healthy people.Molecular Biotechnology 05/2011; 50(1):49-56. DOI:10.1007/s12033-011-9414-6 · 1.88 Impact Factor
Article: Association of Specific Genotypes in Metastatic Suppressor HTPAP with Tumor Metastasis and Clinical Prognosis in Hepatocellular Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: The phosphatidic acid phosphatase HTPAP has been defined as a metastatic suppressor of hepatocellular carcinoma (HCC), but little is known about its function or potential applications as a prognostic marker. In this study, we analyzed patterns of HTPAP genetic variation and gene expression in 864 patients who underwent HCC resection, assessing these patterns for correlations to tumor metastasis potential. Focusing on two tagSNPs that were selected (+357G/C and +1838A/G), we found that only the +357G/C genotype was significantly associated with HTPAP mRNA and protein expression levels and the probability of metastasis. In an independent cohort of 665 HCC patients, we determined that the +357G/C genotype was associated with shorter time to recurrence and overall survival. Together, these results indicated that the HTPAP tagSNP +357 GG+GC genotypes may influence HCC metastatic potential and clinical prognosis by down-regulating HTPAP expression. Extending these results, a global expression profiling analysis identified 41 genes including the pro-inflammatory genes IL-8 and TLR2 that were significantly overexpressed in the +357 GG+GC group, as possible coregulated markers with HTPAP. Together, our findings identify an HTPAP genotype and associated gene expression pattern that favors metastasis progression and that could be used to predict tumor metastasis and prognosis in HCC patients.Cancer Research 05/2011; 71(9):3278-86. DOI:10.1158/0008-5472.CAN-10-3100 · 9.33 Impact Factor
Article: [High expression of thrombin receptor PAR1 in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma in early stage].[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the relationship between PAR1 (Protease-Activated Receptor 1) expression and the clinicopathologic features and to investigate the prognostic value of PAR1 expression in hepatocellular carcinoma (HCC) in early stage after curative resection. Real-time PCR was used to detect PAR1 expression in 41 pairs of tumors and matched peritumoral samples of HCC in early stage. Prognostic value of PAR1 mRNA expression was evaluated. Meanwhile, another 49 tissue paraffin slices of HCC were tested using immunohistochemistry (Envision) and the prognostic value of PAR1 expression and other clinicopathologic factors were evaluated. Peritumoral PAR1 mRNA expression was significantly increased in HCCs from the patients with tumor recurrence as compared with those without recurrence (P < 0.05). Peritumoral PAR1 protein expression was related to tumor differentiation (P < 0.05). Kaplan-Meier analysis showed that Peritumoral PAR1 protein expression was associated with the overall survival (OS) (P < 0.05) of HCC patients and the time to recurrence (TTR) (P < 0.05). The 1, 3 and 5 -year overall survival time and the cumulative recurrence time in the high PAR1 protein expression group were significantly lower as compared to the low PAR1 expression group in the peritumoral liver tissue. Peritumoral PAR1 expression is closely associated with the prognosis of early stage HCC patients after curable surgery. PAR1 may be involved in thrombin-mediated invasion process and may be used as a prognostic marker for HCC.Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 04/2011; 19(4):266-70.
Article: Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Our previous study has identified HTPAP as a novel metastasis suppressor from chromosome 8p which is often deleted in metastatic HCC. We sought to further evaluate the expression levels of transcript variants of HTPAP (HTPAP-1, HTPAP-2 and HTPAP-3) in 67 HCC tumor tissues and 11 normal liver tissues by RT-PCR with specific TaqMan probes and primer sets, and explore their association with HCC metastasis and survival. We found that the expression levels of three HTPAP transcript variants were quite different in HCCs. Only HTPAP-1 was found to be significantly associated with HCC metastasis (P=0.00053), overall survival (P=0.0023) and time to recurrence (P=0.010) of HCC. Patients with a lower expression of HTPAP-1 were inclined to accompany intrahepatic metastases and tumor thrombi (P<0.05) and had a poor prognosis. In vitro, three fusion pEGFP-N1 vectors encoding HTPAP-1, HTPAP-2 and HTPAP-3 were introduced into HCC cells respectively to track HTPAPs' expressions and identify their function. We found overexpression of HTPAP-1 conferred HCC cells reduced ability of invasion without significant impact on cell proliferation, and also displayed a distinct cell location on cell membrane and in cytoplasm, which were different from two other variants. Consequently, HTPAP-1 may be the transcript of HTPAP to exhibit a suppressive role on HCC metastasis, and can be a prognostic marker for HCC.Cancer Science 03/2011; 102(3):583-90. DOI:10.1111/j.1349-7006.2011.01863.x · 3.52 Impact Factor
Article: Thrombin is a Therapeutic Target for Metastatic Osteopontin-Positive Hepatocellular Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: We previously identified osteopontin (OPN) as a promoter and thus a potential therapeutic target for hepatocellular carcinoma (HCC) metastasis. The serine protease thrombin interacts with OPN and can modify its biological activity. To explore the role of thrombin alone or in conjunction with OPN in HCC, we studied the correlation of thrombin levels to HCC prognosis in patients with various OPN levels, and evaluated the effects of OPN fragments generated by thrombin cleavage on proliferation and adhesion of HCC cells. We found that the thrombin level was strongly associated with the metastatic potential of HCC cell lines, and that thrombin was remarkably overexpressed in HCC tissue compared with adjacent nontumor tissue. In addition, HCC tissue from patients with recurrent disease displayed much higher thrombin levels, particularly in those with elevated OPN levels. Only HCCs with elevated OPN levels had a significant correlation between high thrombin levels and overall survival (OS; P < 0.01), or time to recurrence (TTR; P < 0.0001) of HCC. Multivariate analysis revealed that thrombin was an independent prognostic indicator. In vitro assays demonstrated that thrombin promotes the proliferation and adhesion of OPN+ HCC cells. Furthermore, thrombin activated the focal adhesion kinase (FAK) pathway of OPN+ HCC cells, which was blocked by the inhibition of integrin β1. Conclusion: Thrombin plays an important role in OPN-mediated aggressive phenotype of HCC through activation of integrin β1-FAK signaling, and is an independent poor prognostic factor for HCC. Thus, thrombin may be a potential therapeutic target to inhibit HCC metastasis in OPN+ patients.Hepatology 12/2010; 52(6):2012-22. DOI:10.1002/hep.23942 · 11.06 Impact Factor
Article: Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line[Show abstract] [Hide abstract]
ABSTRACT: The effects of mesenchymal stem cells (MSC) on the growth and metastasis of human malignancies including hepatocellular carcinoma (HCC) are controversial, and the underlying mechanisms are not yet understood. The aim of this study was to explore the role of MSC in the progression of HCC. We investigated the effect of MSC on in vitro proliferation and invasion and in vivo tumor growth and pulmonary metastasis of MHCC97-H HCC cells with a high metastatic potential. The mRNA and protein levels of transforming growth factor-beta 1 (TGFβ1) and MMP, and their association with the effects of MSC on HCC cells were also evaluated. Co-culture of MHCC97-H cells with MSC conditioned medium significantly enhanced in vitro proliferation but inhibited invasiveness. Following MSC treatment of a nude mouse model bearing human HCC, the MSC were predominantly located in the HCC tissues. Compared with controls, MSC-treated mice exhibited significantly larger tumors (3080.51 ± 1234.78 mm(3) vs 2223.75 ± 1000.60 mm(3), P = 0.045), but decreased cellular numbers of lung metastases (49.75 ± 18.86 vs 227.22 ± 74.67, P = 0.046). Expression of TGFβ1 and MMP-2 was significantly downregulated in the MSC-treated HCC cells. TGFβ siRNA concurrently downregulated expression of TGFβ and MMP-2 in HCC cells and blocked the MSC-induced proliferation and invasiveness of MHCC97-H cells. The MSC enhanced tumor growth but significantly inhibited the invasiveness and metastasis of HCC, possibly through downregulation of TGFβ1. These findings suggest that MSC could be useful in controlling metastatic recurrence of HCC.Cancer Science 09/2010; 101(12):2546-53. DOI:10.1111/j.1349-7006.2010.01738.x · 3.52 Impact Factor
Article: Huang H, Zhang XF, Zhou HJ, Xue YH, Dong QZ, Ye QH, Qin LXExpression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection. Cancer Sci 101(5): 1314-1319[Show abstract] [Hide abstract]
ABSTRACT: Osteopontin (OPN) plays an important role in the development, invasion, and metastasis of malignancies. Recently, several studies have reported that OPN enhances chemoresistance in small-cell lung cancer and breast cancer by blocking caspase-9 and caspase-3-dependent cell apoptosis. The aim of this study was to assess the value of OPN and caspase-3 for predicting tumor recurrence after curative resection in hepatocellular carcinoma (HCC) patients. We found that OPN expression increased concordantly with increasing metastatic potential in human HCC cell lines, whereas caspase-3 expression declined. In a tumor tissue microarray immunohistochemical analysis, we found that patients with higher levels of OPN and lower levels of caspase-3 had a significantly poorer prognosis than patients with lower OPN and higher caspase-3 levels. The combination of OPN and caspase-3 expression thus served as an effective prognosticator. These findings suggest that OPN alone or in combination with caspase-3 may act as an independent indicator for HCC patients after curative resection.Cancer Science 02/2010; 101(5):1314-9. DOI:10.1111/j.1349-7006.2010.01524.x · 3.52 Impact Factor
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The Depot Renaissance Minneapolis Hotel To Offer Guests Rental Guitars
Thursday January 9th, 2014 - 2:40PM
These are shortcuts to your favorite social networking and bookmark sites. Add this story to your Facebook page, del.icio.us, DiggIt, and many others!
MINNEAPOLIS—The Depot Renaissance Minneapolis Hotel and My Hotel Rocks, LLC, have announced a strategic partnership to offer hotel guests use acoustic guitars for rent on-site or as part of their room package.
The partnership allows The Depot Renaissance to build on the Renaissance Hotels' brand strategy, which highlights music and entertainment as part of their RLife Live events. The program officially launches this month and the cost to rent a guitar is $25 for guests of The Depot and its Stone Arch Bar & Lounge.
The idea originated with My Hotel Rocks founder Dave Musolf, a self-described road warrior/guitar hack who often found himself sitting in his hotel rooms wishing he had his guitar to play.
"I asked everywhere I went, and no hotel ever had a guitar," stated Musolf. "I knew there were a few hipster boutique hotels that had them, but as a business traveler working a loyalty program, these weren't really an option. Minneapolis has such an amazing music scene and The Depot supported this idea right away. It's a perfect fit."
My Hotel Rocks is currently using Ovation guitars in the $550-$650 (Celebrity) range as part of this program. Each guitar has built-in tuners, and can be plugged into a mobile device/headphones supporting the wide range of guitar and music apps available online.
A common concern is about potential noise issues within the hotel. Through a variety of tests, however, the mid/shallow body acoustic guitar ranks below noise levels of parties, TVs, music/radios, and even conversation and phone use as a potential noise issue.
"Most guitarists I know are super respectful and I don't envision hardly any issues with noise," said Musolf. "In fact, The Depot Renaissance has a number of guests who travel with their own guitar, and they've never had a noise complaint related to this."
Tags: Depot Renaissance Minneapolis Hotel • My Hotel Rocks • Hospitality • Amenities •
From lifestyle choices to luxury decisions. Back in January, when we unveiled the newly redesigned Hotel Business, Eric Danziger was the subject of our cover story for the ALIS issue. He had recently joined Hampshire Hotels Management as president and CEO, and had just transformed the operator into a full-fledged brand company, Début Hotel Group, which would become the umbrella for five brands (Augustus Hotels & Resorts, Dream Hotels, Time Hotels, Unscripted Hotels and Night Hotels).
Aloft and Element Hotels Opening in Boston Seaport Early 2016
DoubleTree by Hilton Opens Hotel & Spa in Liverpool »
Mövenpick Hotels & Resorts Expands in Africa
Sheraton Hotels & Resorts Adds New Resort in Panama City, FL
Autograph Collection Adds Three Hotels to Portfolio
AH&LA Applauds ACA Fix to Protect Small Businesses from Higher Premiums
HB ON THE SCENE: Positive Outlook Permeates Lodging Conference Despite Global Headwinds
Access Point Financial, Inc. Closes $225M in Asset Valuation During Q3
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I placed her passive hand in hisWith
how much pain God only knows--
And blessing him for her sweet sake,
I left him standing with my Rose!
"PHOEBE! Phoebe! Where is the chit?
When I want her most she's out of the way.
Child, you're running a long account
Up, to be squared on Judgment-day.
"Where have you been? and what have you there?"
"To the pasture for buttercups wet with dew."
"My patience! I think you are out of your wits;
I wonder what good will buttercups do?
"There's pennyroyal you might have got,-
It might have been useful to you or me,
But I never heard, in all my life,
Of buttercup cordial or buttercup tea.
"I want you to stay and mind the bread,
I've just put two loaves in the oven to bake;
When they are clone take them carefully out,
And put in their place this loaf of cake,
"While I run over to Widow Brown's;
Her son, from the mines, has just got bac
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Library Branch
Book Clubs & Writers' Groups
This is a book club for people who are fluent in French....
Tue Jan 26
Join library staff for entertaining book talks. Refreshments will be provided. Call 416-394-5270 or email email@example.com to register.
Tue Jan 19
The Joy of Writing is a weekly writers' workshop and gathering where we read, write, laugh and inspire each other. Call Lucille at 416-461-3700 for more information. Tuesday evenings at the Ralph Thornton Centre, Mezzanine Le...
St. Lawrence
Nancy Drew turns 85 this year! She remains smart, resourceful, and independent. Get the scoop on Nancy, the people who created her as well as the mystery writers she inspired. Presented by Pamela Hancock, Branch Head, Forest ...
Share your views with us on selected books....
Thu Nov 19
Thu Jan 21
Rejoignez-nous pour parler des livres en nominations des prix Tamarac et Tamarac Express. Lisez 5 livres et vous pouvez voter pour votre favori. Pour les enfants de 9 and et plus. Inscription obligatiore....
Sat Nov 07
Sat Jan 16
The group invites poetry enthusiasts and anyone curious about poetry to our monthly meetings. Activities include sharing and discussing favourite poems, poetry writing exercises, opportunities to share original poems and get ...
Fri Nov 06
Fri Dec 04
Fri Jan 08
Please join fellow book lovers to share and discuss contemporary Chinese literature once a month in a relaxing manner at Agincourt branch. To register, please call 416-396-8950.
Thu Nov 05
Thu Dec 03
Join us for an entertaining and relaxing afternoon with tea, snacks, and a librarian who will introduce you to compelling and exciting library material! For more information, please phone Agincourt library staff at 416-396-89...
Fri Oct 30
Fri Nov 27
Mimico Centennial
Discuss new books and old favourites with library staff. Please note the new start time of 1:30 p.m. Call branch at 416-394-5330 for more information.
Thu Oct 29
Thu Nov 26
Thu Jan 28


text:
that can come to man in this life.
The general impression seems to be that common-sense should lead us to a better use of our machines at once. Whereas, common-sense will not bring a true power of guiding the muscles, any more than it will cause the muscles' development, unless having the common-sense to see the need, we realize with it the necessity for cutting a path and walking in it. For the muscles' development, several paths have been cut, and many who are in need are walking in them, but, to the average man, the road to the best kind of muscular development still remains closed. The only training now in use is followed by sleight-of-hand performers, acrobats, or other jugglers, and that is limited to the professional needs of its followers.
Again, as the muscles are guided by means of the nerves, a training for the guidance of the muscles means, so far as the physique is concerned, first, a training for the better use of the nervous force. The nervous system is so wonderful in its present power
Cara Devon has always suffered curiosity and im... Read more
When the economic downturn ends Matty Cruzs co... Read more
A telekinetic teenager. A telepathic child. A p... Read more
A century after an apocalyptic war reduces all... Read more
Fall in love with the Kensington siblings in th... Read more
See it as donating a moment of your social media time, every little thing helps us improve and stay online.
The list of books below is based on the weekly downloads by our users regardless of eReader device or file format.
See more popular titles from this genre.


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"Where Fillmore County News Comes First"
Online Edition
Saturday, October 10th, 2015
Volume ∞ Issue ∞
USDA enrollment period for agriculture risk coverage and price loss coverage safety-net programs closes Sept. 30
- 12:39:52, Oct 9th 2015 - KingslandGrad95 - As someone who was a student at Kingsland from it's beginning, pare ... [Read More]
- 11:23:47, Oct 9th 2015 - Go Falcons!! - I'd like to give a huge shout out to Fillmore Centrals Volleyball coac ... [Read More]
- 9:10:55, Oct 7th 2015 - @ Concerned - I have wondered about this too. Most of the Wykoff kids don't even go t ... [Read More]
- 2:53:37, Oct 6th 2015 - Concerned - Has the school board & administration ever checked into why so many studen ... [Read More]
- 9:58:41, Oct 6th 2015 - - Why don't you run for school board, SomethingNeedsToBeDone? Write-in candidates we ... [Read More]
- 2:05:39, Oct 5th 2015 - Paul - The Quaran does not tell Muslims to kill non-muslims. In fact it says Muslims a ... [Read More]
- 1:01:48, Oct 5th 2015 - GoldenRule - Let us be mindful of the Golden Rule and how we treat others. Be careful ... [Read More]
- 11:32:26, Oct 5th 2015 - SomethingNeedsToBeDone - Are people blind?? How can they continue to use a facility ... [Read More]
- 11:23:54, Oct 5th 2015 - James1952 - Pig poker- what did you crybaby vote yes losers do both times you lost th ... [Read More]
- 10:51:29, Oct 5th 2015 - Pig poker - We all know why Jon Peterson doesn't want the school, he's mad because he ... [Read More]
Trout stream plan aims to continue positive trend
Fri, Sep 5th, 2003
Posted in Features
Posted in Features
Anglers will find more large trout on their lines if a new 12-year fisheries plan for southeastern Minnesota streams achieves its goals.
The plan, prepared by the Department of Natural Resources, aims to improve stream quality, scientific knowledge and trout populations by working within and beyond the banks of the stream, according to Ron Payer, director of the DNR Fisheries Division. �Southeast Minnesota�s trout populations have been on an upward trend for many years,� Payer said. �Our new strategic plan aims to further improve a high quality fishery through habitat improvement, innovative angling regulations and a commitment from citizens who can to make a difference.� Payer noted that the plan reflects input from anglers, landowners and others who have attended a series of public meetings in recent months. �One strategy we are particularly excited about is called the three-tier system,� Payer said. �Under this proposal, streams or sections of streams would be classified in one of three ways: total catch-and-release, protected slot of 12 to 16 inches, or standard statewide regulation.� The goal is to provide anglers with options suited to their style of fishing while simultaneously applying scientific principles that may increase the number of trout 15 inches or larger. The three-tier system has the support of Trout Unlimited and the Minnesota Trout Association. It could be implemented in 2005 following public input meetings in 2004. The DNR�s new plan includes 40 strategies. They range from broad private-public partnerships to specific guidelines for the use of hatchery-raised trout. A key goal is to meet the needs of as many anglers as possible. Mark Heywood, DNR fisheries manager at Rochester, said staff will begin implementing the plan in 2004. �Thanks to public input, we have defined what needs to be accomplished between now and 2015,� Heywood said. �The next step is to finish an operational plan � who needs to do what � to convert this collective vision into action.� The operational plan will be released this autumn, Heywood said. Meanwhile, the DNR will continue to solicit opinions and suggestions from the public. �The quality of our streams always will be a reflection of the land use around them,� Heywood said. �Realistically, the success of our plan will be linked to the level of cooperation and enthusiasm put forward by citizens, landowners, anglers and governmental entities empowered with conservation responsibilities.� Copies of the plan, called the �Strategic Plan for Coldwater Resources Management in Southeast Minnesota,� are available on the DNR Web site at www.dnr.state.mn.us. Anglers who have specific questions about the three-tier angling regulation system should contact DNR fisheries offices at Lake City, Lanesboro or Rochester. Source: Minnesota DNR


text:
Yoga is now taught as part of the P.E. program in public schools across the country, and at all levels from kindergarten to high school senior. There's a good reason for that: yoga is an excellent way to ease stress in the busy lives of our students today, it's open to kids of all athletic abilities, and it doesn't require any special equipment.
That didn't stop a family in a San Diego suburb from requesting that their local school district stop including yoga in physical education, arguing that it violated the First Amendment and separation of church and state.
Stephen and Jennifer Sedlock and their two children, who sued the Encinitas school district earlier this year, have lost their case.
On July 1, a judge ruled that a public school district can teach yoga, taking the side of school administrators who argued the practice is a secular way to promote strength, flexibility and balance, and that it does not amount to teaching children religion.
He agreed that yoga is a religious practice, but not the way that it is taught by the Encinitas Union School District at its nine campuses:
"Yoga as it has developed in the last 20 years is rooted in American culture, not Indian culture," San Diego Superior Court Judge John Meyer said. "It is a distinctly American cultural phenomenon. A reasonable student would not objectively perceive that Encinitas school district yoga advances or promotes religion."
Hooray for some sanity in this case!
In illustrating his point, Meyer explained that the school district has stripped classes of all cultural references, including the Sanskrit language. The lotus position has even been renamed the "crisscross applesauce" pose!
Superintendent Timothy Baird hailed the ruling, calling yoga "21st century P.E." that yielded "amazing" health benefits. His district is believed to be the first in the country to have full-time yoga teachers at every one of its schools.
The lessons, funded by a $533,720, three-year grant from the non-profit K.P. Jois Foundation, are offered to the district's 5,600 students, in addition to regular P.E.
Bizarrely, the lawyer for the Sedlocks, Dean Broyles, said the judge's ruling was part of a broader bias against Christianity. According to Broyles: yoga "is religious and has religious aspects. There is a consistent anti-Christian bias in these cases, and a pro-Eastern or strange religion bias."
A "strange religion" bias? Is he referring to the eight-limbed tree posters the Sedlocks said were derived from Hindu beliefs, the Namaste greeting and several of the yoga poses that they said represent the worship of Hindu deities?
First of all, I wonder if Mr. Broyles has ever actually taken a yoga class? Does he know what goes on there? Does he imagine the yoga instructor gets everyone into some weird position, makes them hold still and then indoctrinates them in "strange religion"?
Much more troubling in this mindset is the notion that Christianity is the only acceptable religion for the U.S., in spite of the facts that a plethora of other religions exist and that 16 percent of our citizens hold no religion at all. The wonderful multicultural and multi-ethnic mix is one of the main reasons many of us came to the U.S. as immigrants. Indeed, the San Diego region itself is a multi-ethnic area, embracing many religions.
On a practical level, if the Sheldons really believe that yoga is being used to subtly brainwash their kids, they can choose to opt out of the twice-weekly, 30-minute classes, as about 30 families have done.
Apparently Mr. Broyles is not convinced that this is the answer and is planning an appeal.
Meanwhile, the lucky Encinitas students can continue to enjoy their weekly 60 minutes of relaxation.
What do you think? Could it be that the Encinitas school district is trying to brainwash its students?
Read more: california, christianity, eastern philosophy, encinitas union school district, first amendment, hinduism, namaste, physical education, public schools, religion in schools, san diego, southern california, yoga
Photo Credit: istock
A green star for Lika S.
Yoga≠religion. Dunno what that dumb lawyer's on about.
or klik on NEW sexsual abuse scandal - you will protect your children and youth
Just klik on the link and watch
I have just returned from the 24 th Youth Festival of Medjugorje it was a wonderful, 60 countries, with our mother Mary, I want to share with you a part of this atmosphere, more on
www. 24 youtfestival medjugorje 2013
god bless you all
Well, Christianity (and other religions and faiths, too) teach us that our bodies are temples. In this day and age, where it seems that obesity and learning disabilities are diagnosed on the rise, yoga seems like a good place to start with fitness.
Yoga teaches us how to calm our minds to focus, as well as to stretch our bodies to be more flexible, which leads to being able to accomplish a lot more mentally and physically. It doesn't have to do with religion.
And, so, because it's about fitness that even the worst case scenario can help us, this is a good way to get our students more focused and fit. Whomever has a problem with this, I think has a problem themselves.
They removed all "cultural references, including the Sanskrit language." Plus they have the option to opt their kids out of the class so they really don't have anything to complain about. Crisscross applesauce what more do you need?
Save your breath Suzen... you know how it goes... " My way or the Highway* . :P
Wait till Ines finally meets Jesus and finds out He taught Truth Absolute, which belongs neither to the East nor the West but to all, and never bothered to start a religion since religions LIMIT "God' to their own way of thinking.
That He would have encouraged His followers to practice yoga is a no brainer... since it is the best way to still the Mind and become One Pointed ... in this case.. on "God". Gawd forbid someone should use yoga as a wonderful tool to find inner peace, a healthy body and mind. But hey ... you can lead a horse to water but you can't make em Think.
SUZEN R & INES B: I would enthusiastically suggest that the both of you could be putting your time to better use than posting on this web-site on this topic. Don and I CAN! :-))
Besides, this is America. American schools do not teach any specific relgion. Unless they teach all of them. Worrying about if yoga is anti-christian is un-American.
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text:
By the time the bacteria had stopped growing, the concentration of the PHT derivatives had de-creased by 50-55 percent. When further MEA and EG were added, the overall PHT decrease was 83 percent.
In the absence of a carbon source other than PHT, the PHT levels remained constant. When no bacteria were present, the PHT concentrations also remained constant.
The authors conclude that the 1,4-perhydrothiazines undergo transformation by the microbial cells when a growth substrate (MEA/EG) is present. However as the cells did not grow in the presence of PHT alone, the authors conclude that the bacteria cannot use them for growth.
The group hopes that the bacterial strain can be used in the context of plant-microbial associa-tions to create a new generation of biotechnologies for remediation of soils contaminated by CWAs or products of their detoxification.
"Bioutilization of organic compounds of reaction masses is a biotechnological method that pro-vides maximum environmental safety, since the pollutants are naturally degraded to innocuous products such as carbon dioxide and water, as well as microbial biomass," said Dr. Ermakova.
Article: "Microbial degradation of the detoxification products of mustard from the Russian chemical weapons stockpile," Inna T Ermakova, Natalya S Safrina, Ivan I Starovoitov, Yelena V Lyubun, Alexander A Shcherbakov, Oleg E Makarov, Paul V Kosterin, and Alexander M Boronin, Journal of Chemical Technology and Biotechnology; Published Online: March 2, 2005.