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I am allergic to Sulfa and many preservatives. Is there an Albuterol inhaler without the Sulfate?
What is Albuterol Sulfate. Is Sulfate Sulfa?
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For how many days albuterol stay good after the experation day in the box?
albuterol sulfate 0.83% 30x3ml unit dose vials
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Mouth ulcers & indigestion - could these be side effects of Albuterol, Ipratropiun or alendronate?
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Does the albuterol sulfate inhalation solution make you eat alot and hyper?
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Albuterol - My Dr. prescribed Budesonide to be administered as a nasal spray, can I use Albuteral?
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I was prescribed Albuterol Sulfate, after taking it I became dizzy and weak, what should I do?
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Publications (72)349.19 Total impact
Article: Incomplete Apobec3G/F neutralization by HIV-1 Vif mutations facilitates the genetic evolution from CCR5 to CXCR4 usage[Show abstract] [Hide abstract]
ABSTRACT: An incomplete Apobec3G/F neutralization by defective HIV-1Vif protein can promote genetic diversification, by inducing G-to-A mutations along HIV-1 genome. The HIV-1 Env V3 loop, critical for co-receptor usage, contains several putative Apobec3G/F target sites. Here, we determined if Apobec3G/F, in presence of Vif-defective HIV-1 virus, can induce G-to-A mutations at V3 positions critical to modulate CXCR4-usage.PBMC and monocyte-derived-macrophages (MDM) from 2 HIV-1 negative donors were infected by CCR5-using 81.A-Vifwt, 81.A-VifE45G-mutant, and 81.A-VifK22E-mutant (known to incompletely/partially neutralize Apobec3G/F). The rate of G-toAs was null or extremely low in 81.A-Vifwt and 81.A-VifE45G infected PBMC from both donors. Conversely, a G-to-As enrichment was detected in 81.A-VifK22E infected PBMC (prevalence ranging from 2.18% at 7dpi to 3.07% at 21dpi in donor #1, and from 10.49% at 7dpi to 8.69% at 21dpi in donor #2). A similar scenario was found in MDM.G-to-As occurred at 8 V3 positions, resulting in amino acid non-synonymous substitutions. Of them, G24E and E25K strongly correlated with phenotypically/genotypically defined CXCR4-using viruses (P-value = 0.04 and 5.5e-7), and increased CXCR4 N-terminus binding affinity for V3 (WT: -40.1Kcal/mol; G24E: -510Kcal/mol; E25K: -522Kcal/mol).The analysis of paired V3 and Vif DNA sequences from 84 HIV-1 infected patients showed that the presence of a Vif-defective virus correlated with a CXCR4-usage in proviral DNA (P-value=0.04). In conclusion, incomplete Apobec3G/F neutralization by single Vif amino acid substitution seeds a CXCR4-using proviral reservoir. This can have implications for the success of CCR5 antagonist-based therapy, as well as for the risk of disease progression. Copyright © 2015, American Society for Microbiology. All Rights Reserved.Antimicrobial Agents and Chemotherapy 06/2015; 59(8):AAC.00137-15. DOI:10.1128/AAC.00137-15 · 4.48 Impact Factor
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ABSTRACT: Virological failure (VF) in patients on maraviroc-based treatment has been associated with altered HIV tropism and resistance to maraviroc. This multicentre study aimed to characterize VF in patients treated with maraviroc. We analysed 27 patients whose treatment failed between 2008 and 2011. They had been screened for HIV tropism before maraviroc initiation using population-based V3 genotyping. HIV-1 tropism and resistance of R5 viruses to maraviroc at VF and at baseline were determined retrospectively using an ultrasensitive recombinant virus assay (RVA). Viruses from 27 patients given maraviroc on the basis of the R5 genotype were characterized at the time of treatment failure. The RVA indicated that 12 patients harboured CXCR4-using viruses and 15 (56%) had pure R5 viruses at failure. One-third of those harbouring CXCR4-using viruses (4/12) were infected with R5X4/X4 viruses according to the RVA before maraviroc initiation. We analysed the phenotypic resistance to maraviroc of four patients harbouring R5 viruses at failure; two harboured viruses whose maximum percentage inhibition was reduced by 65%-90%, while the other two were infected with susceptible viruses. All patients had effective concentrations of drugs. Half of the maraviroc-treated patients who experienced VF harboured CXCR4-using viruses at failure, one-third of them were detected by a phenotypic method before maraviroc initiation. Phenotypic assessment of R5 virus resistance to CCR5 antagonists at failure could help optimize antiretroviral therapy. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: email@example.com of Antimicrobial Chemotherapy 02/2015; 70(6). DOI:10.1093/jac/dkv026 · 5.31 Impact Factor
Article: Efficacy of etravirine combined with darunavir or other ritonavir-boosted protease inhibitors in HIV-1-infected patients: an observational study using pooled European cohort data[Show abstract] [Hide abstract]
ABSTRACT: Objectives This observational study in antiretroviral treatment-experienced, HIV-1-infected adults explored the efficacy of etravirine plus darunavir/ritonavir (DRV group; n = 999) vs. etravirine plus an alternative boosted protease inhibitor (other PI group; n = 116) using pooled European cohort data.Methods Two international (EuroSIDA; EUResist Network) and five national (France, Italy, Spain, Switzerland and UK) cohorts provided data (collected in 2007–2012). Stratum-adjusted (for confounding factors) Mantel–Haenszel differences in virological responses (viral load < 50 HIV-1 RNA copies/mL) and odds ratios (ORs) with 95% confidence intervals (CIs) were derived.ResultsBaseline characteristics were balanced between groups except for previous use of antiretrovirals (≥ 10: 63% in the DRV group vs. 49% in the other PI group), including previous use of at least three PIs (64% vs. 53%, respectively) and mean number of PI resistance mutations (2.3 vs. 1.9, respectively). Week 24 responses were 73% vs. 75% (observed) and 49% vs. 43% (missing = failure), respectively. Week 48 responses were 75% vs. 73% and 32% vs. 30%, respectively. All 95% CIs around unadjusted and adjusted differences encompassed 0 (difference in responses) or 1 (ORs). While ORs by cohort indicated heterogeneity in response, for pooled data the difference between unadjusted and adjusted for cohort ORs was small.Conclusions These data do not indicate a difference in response between the DRV and other PI groups, although caution should be applied given the small size of the other PI group and the lack of randomization. This suggests that the efficacy and virology results from DUET can be extrapolated to a regimen of etravirine with a boosted PI other than darunavir/ritonavir.HIV Medicine 02/2015; 16(5). DOI:10.1111/hiv.12218 · 3.99 Impact Factor
Article: Antiretroviral-Experienced HIV-1-Infected Patients Treated with Maraviroc: Factors Associated with Virological Response[Show abstract] [Hide abstract]
ABSTRACT: There are few data on the clinical and virological factors associated with maraviroc (MVC) virological response (VR) in clinical practice. This study aimed to identify factors associated with VR to MVC-containing regimens in 104 treatment-experienced but CCR5 inhibitor-naive HIV-1 patients. VR was defined at Month 3 (M3) as HIV-1 RNA viral load (VL) <50 copies/mL. The impact on VR of age, sex, baseline tropism, HIV subtype (B vs non-B), nadir CD4 cell count and CD4 cell count, baseline VL, genotypic susceptibility score of treatment, once or twice daily treatment, presence of raltegravir in optimized background therapy and MVC concentrations was investigated. Median baseline VL was 3.3 log10 copies/mL (range 1.7-6.0 log10 copies/mL) and CD4 cell count was 299 cells/mm3 (range 7-841 cells/mm3). At M3, 53.8% of patients were responders. In univariate analysis, a better efficacy of MVC-containing regimen was associated with a high CD4 cell count (p=0.0069) and there was a trend for low baseline VL, high nadir CD4 cell count and HIV subtype (B versus non B). Only low baseline VL remained significantly associated with better VR in the multivariate analysis. This study demonstrated a VR of an optimized antiretroviral treatment including MVC in clinical practice similar to that observed in clinical trials. The factors associated with VR were higher baseline CD4 cell count in univariate analysis and lower baseline VL in multivariate analysis.AIDS Research and Human Retroviruses 11/2014; 31(5). DOI:10.1089/AID.2014.0223 · 2.33 Impact Factor
Article: High level of HIV-1 resistance in patients failing long-term first-line antiretroviral therapy in Mali[Show abstract] [Hide abstract]
ABSTRACT: Objectives: In resource-limited settings, few data are available on virological failure after long-term first-line antiretroviral therapy. This study characterized the genotypic resistance patterns at the time of failure after at least 36 months of a first-line regimen in Mali, West Africa. Methods: Plasma samples from 84 patients who were receiving first-line antiretroviral treatment and with an HIV-1 RNA viral load (VL) >1000 copies/mL were analysed. Genotypic resistance testing was performed and HIV-1 drug resistance was interpreted according to the latest version of the National Agency for HIV and Hepatitis Research algorithm. Results: At the time of resistance testing, patients had been treated for a median of 60 months (IQR 36-132 months) and had a median CD4 cell count of 292 cells/mm(3) (IQR 6-1319 cells/mm(3)), a median HIV-1 RNA level of 28266 copies/mL (IQR 1000-2 93 495 copies/mL) and a median genotypic susceptibility score of 1 (IQR 1-4). The prevalence of nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance mutations was 78% and 82%, respectively. Viruses were resistant to at least one drug in 92% of cases. Although etravirine and rilpivirine were not used in the first-line regimens, viruses were resistant to etravirine in 34% of cases and to rilpivirine in 49% of cases. The treatment duration, median number of NRTI and NNRTI mutations and some reverse transcriptase mutations (T215Y/F/N, L210W, L74I, M41L and H221Y) were associated with the VL at virological failure. Conclusions: This study demonstrated a high level of resistance to NRTIs and NNRTIs, compromising second-generation NNRTIs, for patients who stayed on long-term first-line regimens. It is crucial to expand the accessibility of virological testing in resource-limited settings to limit the expansion of resistance and preserve second-line treatment efficacy.Journal of Antimicrobial Chemotherapy 05/2014; 69(9). DOI:10.1093/jac/dku153 · 5.31 Impact Factor
Article: Rilpivirine, emtricitabine and tenofovir resistance in HIV-1-infected rilpivirine-naive patients failing antiretroviral therapy[Show abstract] [Hide abstract]
ABSTRACT: In the context of simplification strategies, it is essential to know the feasibility of a switch to a rilpivirine-based therapy. The aim of this study was to describe rilpivirine, tenofovir and emtricitabine resistance in HIV-1-infected patients who experienced virological failure during their previous antiretroviral treatment. The studied population included two groups of patients, all rilpivirine naive, tested for resistance by bulk sequencing from 2008 to 2011: the first group (n = 998) failing a nucleoside reverse transcriptase inhibitor (NRTI) plus boosted protease inhibitor (PI)-based regimen and the second group (n = 3733) failing an NRTI plus non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen. In the first group, the frequency of rilpivirine mutations and resistance to rilpivirine (5.1%) was similar to that in antiretroviral-naive HIV-1-infected patients. Among the 1605 patients from the second group with at least one NNRTI mutation in their HIV, the prevalence of viruses 'resistant' or 'possibly resistant' to efavirenz, nevirapine and etravirine was 78%, 79% and 74%, respectively, while 59% were resistant to rilpivirine. Resistance to rilpivirine was significantly more frequent in non-B subtype versus B subtype viruses. Among pretreated patients with viruses with at least one NNRTI mutation (other than for rilpivirine), 22% of sequences were susceptible to the combination rilpivirine/emtricitabine/tenofovir disoproxil fumarate. In patients failing an NRTI plus NNRTI-based regimen, to know the feasibility of a switch to rilpivirine/emtricitabine/tenofovir disoproxil fumarate, reliable resistance information should be available at the time of use of concurrent NNRTI therapy.Journal of Antimicrobial Chemotherapy 12/2013; 69(4). DOI:10.1093/jac/dkt463 · 5.31 Impact Factor
Article: National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011[Show abstract] [Hide abstract]
ABSTRACT: Objectives: As recommended by the French ANRS programme for the surveillance of HIV-1 resistance, we estimated the prevalence of transmitted drug resistance-associated mutations (RAMs) in antiretroviral-naive, chronically HIV-1-infected patients. Methods: RAMswere sought in samples from661 newly diagnosed HIV-1-infected patients in 2010/11 at 36 HIVclinical care centres.Weighted analyses were used to derive representative estimates of the percentage of patients with RAMs. Results: At patient inclusion, the prevalence of viruswith protease (PR) or reverse transcriptase (RT) RAMswas 9.0%(95% CI 6.8%-11.2%). No integrase RAMs were observed. The prevalences of protease inhibitor, nucleoside RT inhibitor and non-nucleoside RT inhibitor RAMs were 1.8%, 6.2% and 2.4%, respectively. Resistance to one, two and three classes of antiretroviral agent was observed in 7.9%, 0.9% and 0.2% of patients, respectively. The frequency of RAMs was higher in patients infected with B compared with non-B subtype virus (11.9% versus 5.1%, P=0.003). Baseline characteristics (gender, age, country of transmission, CD4 cell count and viral load)were not associated with the prevalence of transmitted RAMs. However, men having sex with men (MSM)were more frequently infected with resistant virus than were other transmission groups (12.5%versus5.8%,P=0.003).Compared with the 2006/07 survey, the over all prevalence of resistance remained stable. However, a significant decrease in the frequency of virus with PRRAMs was observed in 2010/11 compared with the 2006/07 survey (1.8%versus 5.0%, P=0.003). Conclusions: In France in 2010/11, the global prevalence of transmitted drug-resistant variants was 9.0%, and the prevalence was stable compared with the 2006/07 survey. MSM and B subtype-infected patients are the groupswith a higher prevalence of drug resistance. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.Journal of Antimicrobial Chemotherapy 11/2013; 68(11):2626-2631. DOI:10.1093/jac/dkt238 · 5.31 Impact Factor
Article: Efficacy of raltegravir switching strategies in HIV-infected patients with suppressed viraemia according to the genotypic sensitivity score[Show abstract] [Hide abstract]
ABSTRACT: The lack of antiretroviral (ARV) backbone activity associated with raltegravir has been proposed as the main explanation for virological relapse observed in patients with undetectable viraemia who are switched from a ritonavir-boosted protease inhibitor (PI) to raltegravir. However ARV activity remains difficult to assess in this context. The aim of our study was to precisely assess the ARV backbone activity in patients with undetectable viraemia who underwent raltegravir switching strategies and to evaluate the efficacy of such switching strategies based on the genotypic sensitivity score (GSS). Patients with a plasma human immunodeficiency virus type 1 (HIV-1) RNA level of <50 copies/mL on a stable two ARV-class regimen were enrolled if they switched one of their ARV drugs to raltegravir 400 mg twice daily. The GSS was calculated using a genotyping test performed on the HIV-1 RNA of the last plasma measurement with a HIV-1 RNA level of >50 copies/mL before the switch and on the results of all previous genotyping tests. The primary endpoint was the proportion of patients with a plasma HIV-1 RNA level of <50 copies/mL at week 24. Fifty-six patients were enrolled in this study. The proportion of patients with a plasma HIV-1 RNA level of <50 copies/mL at week 24 was 92.9 % (range 83.0-97.2 %) in the intent-to-treat analysis and 98.1 % (90.0-99.7 %) in per-protocol analysis. When the backbone was fully active, the proportion was 100.0 % (86.7-100.0 %) at week 24 and week 48 in the per-protocol analysis. We observed a decrease in plasma total cholesterol and triglycerides of -12.7 % (p = 0.005) and -26.5 % (p = 0.001), respectively. Raltegravir switching strategies are effective when the associated backbone is fully active according to the GSS. In the context of undetectable viraemia, where ARV activity remains difficult to assess, the determination of the GSS requires the entire ARV history of the patient and all previous HIV-RNA genotyping test results.Infection 10/2013; 42(2). DOI:10.1007/s15010-013-0542-8 · 2.62 Impact Factor
Article: Dual Therapy With Lamivudine + Protease Inhibitor During Pregnancy for Prevention of Mother-to-Child Transmission of HIV-1JAIDS Journal of Acquired Immune Deficiency Syndromes 08/2013; 63(5):e159-63. DOI:10.1097/QAI.0b013e31829b2c4b · 4.56 Impact Factor
Article: Genetic barrier to the development of resistance to rilpivirine and etravirine between HIV-1 subtypes CRF02_AG and B[Show abstract] [Hide abstract]
ABSTRACT: It has been demonstrated for some drugs that the genetic barrier, defined as the number of genetic transitions and/or transversions needed to produce a resistance mutation, can differ between HIV-1 subtypes. We aimed to assess differences in the genetic barrier for the evolution of resistance to the second-generation non-nucleoside reverse transcriptase inhibitors etravirine and rilpivirine in subtypes B and CRF02_AG in antiretroviral-naive patients. An analysis was undertaken of 25 substitutions associated with etravirine and rilpivirine resistance at 12 amino acid positions in 267 nucleotide sequences (136 HIV-1 B and 131 HIV-1 CRF02_AG subtypes) of the reverse transcriptase gene. The majority (7/12) of amino acid positions studied were conserved between the two HIV-1 subtypes, leading to a similar genetic barrier. Different predominant codons between the subtypes were observed in 5/12 positions (90, 98, 179, 181 and 227), with an effect on the calculated genetic barrier only at the V179D and V179F codons (2.5 versus 3.5 for V179D, and 2.5 versus 5 for V179F, respectively, for subtype B versus subtype CRF02_AG). The majority of amino acids involved in etravirine and rilpivirine resistance showed a high degree of conservation of the predominant codon between the B and CRF02_AG subtypes. For rilpivirine, the genetic barrier was the same between the two subtypes. Nevertheless, subtype CRF02_AG showed a higher genetic barrier to acquiring mutations V179D and V179F (mutations associated with resistance to etravirine) compared with subtype B, suggesting that it would be more difficult to produce resistance to etravirine in the CRF02_AG subtype than the B subtype.Journal of Antimicrobial Chemotherapy 07/2013; 68(11). DOI:10.1093/jac/dkt251 · 5.31 Impact Factor
Article: A single amino-acid change in a highly conserved motif of gp41 elicits HIV-1 neutralization and protects against CD4 depletion.[Show abstract] [Hide abstract]
ABSTRACT: Background. The induction of neutralizing antibodies against conserved regions of the HIV-1 envelope protein is a major goal of vaccine strategies. We previously identified 3S, a critical conserved motif of gp41 that induces the NKp44 L ligand of an activating NK receptor. In vivo, anti-3S antibodies protect against the NK-cell mediated CD4 depletion that occurs without efficient viral neutralization. Methods. Specific substitutions within the 3S peptide motif were prepared by directed mutagenesis. Virus production was monitored by measuring the p24 production. Neutralization assays were performed with immune-purified antibodies from immunized mice and a cohort of HIV-infected patients. Expression of NKp44 L on CD4+ T cells and degranulation assay on activating NK cells were both performed by flow cytometer. Results. Here, we show that specific substitutions in the 3S motif reduce viral infection without affecting gp41 production, while decreasing both its capacity to induce NKp44 L expression on CD4+ T cells and its sensitivity to autologous NK cells. Generation of antibodies in mice against the W614 specific position in the 3S motif elicited a capacity to neutralize cross-clade viruses, notable in its magnitude, breadth and durability. Antibodies against this 3S variant were also detected in sera from some HIV-1 infected patients, demonstrated both neutralization activity and protection against CD4 depletion. Conclusions. These findings suggest that a specific substitution in a 3S-based immunogen might allow the generation of specific antibodies, providing a foundation for a rational vaccine that combine a capacity to neutralize HIV-1 and to protect CD4+ T cells.Clinical Infectious Diseases 05/2013; · 8.89 Impact Factor
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ABSTRACT: Human herpes virus 8 (HHV-8) is an oncogenic gamma-herpes virus first described in 1994 in Kaposi sarcoma (KS) lesions. HHV-8 is involved in the pathophysiologic features of multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL), both rare B-cell lymphoproliferative diseases. HHV-8-related tumours occur almost exclusively in immunocompromised patients, most with HIV infection. Combined antiretroviral therapies have reduced the incidence of KS but not MCD and PEL. HHV-8-related diseases frequently exhibit pulmonary involvement, which may indicate the disease. KS in the lung is often asymptomatic but may require specific therapy. It mostly shows cutaneous or mucosal involvement. Patients with typical MCD present fever and lymphadenopathy associated with interstitial lung disease without opportunistic infection. Specific treatment may be urgent. PEL provokes a febrile, lymphocytic-exudative pleural effusion, without pleural mass on CT scan. Rapid diagnosis prevents unnecessary exams and leads to specific, rapid treatment. Therapy is complex, combining antiretroviral therapy and chemotherapy.European Respiratory Journal 02/2013; DOI:10.1183/09031936.00154212 · 7.64 Impact Factor
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ABSTRACT: There is evidence that HIV-1 evolution under maraviroc (MVC) pressure can lead to the selection of either X4-tropic variants and/or R5-tropic, MVC-resistant isolates. However, the viral dynamics of HIV-1 variants in patients with virological failure (VF) on MVC-containing regimens remain poorly studied. Here, we investigated the V3 loop evolution of HIV-1 on MVC in relation to coreceptor usage and the nature of HIV-1 quasispecies before MVC therapy using bulk population sequences and ultradeep sequencing. The majority of patients had no detectable minority X4 variant at baseline. The evolution of tropism was followed up until VF and showed three possibilities for viral evolution in these patients: emergence of preexisting X4 variants, de novo selection of R5 variants presenting V3 loop mutations, or replication of R5 variants without selection of known mutations.Antimicrobial Agents and Chemotherapy 02/2013; 57(2). DOI:10.1128/AAC.02159-12 · 4.48 Impact Factor
Article: NRTI-sparing regimens yield higher rates of drug resistance than NRTI-based regimens for HIV-1 treatment[Show abstract] [Hide abstract]
ABSTRACT: To treat human immunodeficiency virus (HIV)-infected patients, international guidelines recommend the combination of two nucleos(t)ide reverse transcriptase inhibitors [N(t)RTIs] and a third agent [non-NRTI (NNRTI), boosted protease inhibitor (r/PI) or integrase inhibitor (INI)] for initial treatment. The objective of this study was to compare the selection of resistance to antiretrovirals (ARVs) for regimens containing or lacking N(t)RTIs in patients experiencing their first virological failure. Eligible patients had a first virological failure, defined as the occurrence of two consecutive HIV plasma viral loads ≥50 copies/mL. Genotypic resistance testing was performed at the time of virological failure (on the second sample with detectable viral load ≥50 copies/mL) in patients failing regimens of N(t)RTIs + r/PI or NNRTI or INI, r/PI + NNRTI or INI, and INI + NNRTI. Among 434 virological failures analysed, resistance testing results were available in 416 cases (95.9%). Higher rates of drug resistance were observed in patients receiving N(t)RTI-sparing regimens. When the combination of N(t)RTIs + r/PI was used, PIs protect themselves and the associated N(t)RTIs from the selection of resistance; however, this was not observed with the NNRTI + r/PI combination. The same phenomenon was observed for raltegravir: when used in combination with N(t)RTIs, INI resistance mutations were less frequently selected compared with its use in combination with PIs or NNRTIs. In conclusion, regimens of the ARV classes combined impact the frequency of resistance development. Lower resistance is observed for N(t)RTI-based regimens, with more therapeutic options for subsequent regimens after failure.Journal of Global Antimicrobial Resistance 01/2013; 2(2). DOI:10.1016/j.jgar.2013.12.001 · 1.09 Impact Factor
Article: HIV-1 integrase variability and relationship with drug resistance in antiretroviral-naive and -experienced patients with different HIV-1 subtypesJournal of Antimicrobial Chemotherapy 11/2012; 68(4). DOI:10.1093/jac/dks474 · 5.31 Impact Factor
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ABSTRACT: The aims of the study were to assess the risk of HHV8 transmission resulting from organ transplantation, and related morbidity in liver, heart and kidney transplant recipients. Donor and recipient serologies were screened between January 1, 2004 and January 1, 2005 using HHV8 indirect immunofluorescence latent assay (latent IFA) and indirect immunofluorescent lytic assay (lytic IFA). Recipients negative for latent IFA with a donor positive for at least one test were sequentially monitored for HHV8 viremia and underwent serological tests over a period of 2 years. The results showed that among 2354 donors, HHV8 seroprevalence was 9.9% (lytic IFA) and 4.4% (latent IFA). A total of 454 organ recipients (281 renal, 116 liver and 57 heart) were monitored over a 2-year period. Seroconversion was observed in 12 patients (cumulative incidence 28%) whose donor had positive latent IFA and in 36 patients (cumulative incidence 29%) whose donors were positive only for lytic IFA, without differences across types of transplants. Positive HHV8 viremia was detected in only 4 out of 89 liver transplant recipients during follow-up and not in recipients of other types of transplant. Two liver transplant recipients and one kidney transplant recipient developed KS. In conclusion, although HHV8 transmission is a frequent event after organ transplantation, HHV8-related morbidity is rather rare but can be life threatening. Donor screening is advisable for monitoring HHV8 seronegative liver transplant recipients.American Journal of Transplantation 10/2012; 13(1). DOI:10.1111/j.1600-6143.2012.04290.x · 5.68 Impact Factor
Article: Switch From Etravirine Twice Daily to Once Daily in Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Resistant HIV-Infected Patients With Suppressed Viremia: The Monetra Study[Show abstract] [Hide abstract]
ABSTRACT: Background: Etravirine (ETR) is recommended as twice-daily dosing in pretreated patients. There are no data regarding the use of ETR once daily in HIV-experienced patients with prior resistance to first-generation non-nucleoside reverse transcripase inhibitors (NNRTIs).Objectives: To evaluate the capacity of once-daily ETR to maintain suppressed viremia over 48 weeks after switching from ETR twice daily in NNRTI-experienced patients.Methods: In this pilot open-label study, patients with plasma viral load (pVL) <50 copies/mL on a stable ETR 200 mg bid regimen were enrolled to switch to ETR 400 mg qd and followed up over 48 weeks. The primary endpoint was the proportion of patients with pVL <50 copies/mL at week 24. Secondary endpoints included the rate of pVL< 50 copies/mL at week 48, ETR pharmacokinetic parameters, and tolerability and resistance profile.Results: Twenty-four patients were included. They had extensive antiretroviral treatment for a median of 14 years (range, 1-19). All except for 2 had prior resistance to NNRTIs. Seven patients discontinued ETR once daily prior to week 48 for virological failure (3), protocol deviation (3), and side effects (1). At week 24, 95% of patients maintained pVL< 50 copies/mL (95% CI, 78.4-99.7) and 85% at week 48 (95%CI, 65.6-95.8). Two of the 3 patients with virological failure had ETR resistance mutations prior to initiation. The median ETR Ctrough level remained stable after switching from twice daily 515 ng/mL (340-758) to once daily 422 ng/mL (264-655).Conclusion: These results suggest that ETR is effective as a once-daily regimen in patients with prior NNRTI experience when HIV is sensitive to ETR. The stability of Ctrough concentrations on a once-daily regimen confirms the once-daily profile of the drug in experienced patients.HIV Clinical Trials 09/2012; 13(5):284-8. DOI:10.1310/hct1305-284 · 2.63 Impact Factor
Article: HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs[Show abstract] [Hide abstract]
ABSTRACT: Precise characterization of viruses present in reservoirs in long-term pretreated patients will be a major issue to consider in the context of viral eradication. We assessed the frequency of defective viruses present in cellular reservoirs. Peripheral blood mononuclear cells (PBMCs) and rectal biopsy samples were compared between five patients on successful long-term highly active antiretroviral therapy (HAART) (>7 years without blips) and five untreated patients. Molecular cloning and sequencing of the reverse transcriptase region were used to detect the presence of and quantify in-frame stop codons in HIV quasi-species. The relationship between the size of the reservoir and the frequency of defective genomes was assessed. Defective genomes were systematically detected in all patients on long-term HAART in both compartments (PBMCs and rectal tissues), with a higher level of defective genomes per sample compared with PBMCs of untreated patients. A high level of defective genomes was correlated with a small size of HIV proviral DNA. Regarding the nucleotide context, guanine (G) to adenine (A) substitution at tryptophan positions was responsible for the appearance of 89% of all in-frame stop codons in the context of G-to-A hypermutation, likely reflecting APOBEC3 footprints on the viral genome. We propose a scenario whereby defective genomes accumulate during HAART treatment, eventually reaching a viral extinction threshold. In the context of viral eradication, measurement of the relative amounts of defective and non-defective viruses (by molecular cloning and ultradeep sequencing) should be used as a new criterion for eradicating HIV.Journal of Antimicrobial Chemotherapy 06/2012; 67(10):2323-6. DOI:10.1093/jac/dks219 · 5.31 Impact Factor
Article: Investigation of Super Learner Methodology on HIV-1 Small Sample: Application on Jaguar Trial Data[Show abstract] [Hide abstract]
ABSTRACT: Background. Many statistical models have been tested to predict phenotypic or virological response from genotypic data. A statistical framework called Super Learner has been introduced either to compare different methods/learners (discrete Super Learner) or to combine them in a Super Learner prediction method. Methods. The Jaguar trial is used to apply the Super Learner framework. The Jaguar study is an "add-on" trial comparing the efficacy of adding didanosine to an on-going failing regimen. Our aim was also to investigate the impact on the use of different cross-validation strategies and different loss functions. Four different repartitions between training set and validations set were tested through two loss functions. Six statistical methods were compared. We assess performance by evaluating R(2) values and accuracy by calculating the rates of patients being correctly classified. Results. Our results indicated that the more recent Super Learner methodology of building a new predictor based on a weighted combination of different methods/learners provided good performance. A simple linear model provided similar results to those of this new predictor. Slight discrepancy arises between the two loss functions investigated, and slight difference arises also between results based on cross-validated risks and results from full dataset. The Super Learner methodology and linear model provided around 80% of patients correctly classified. The difference between the lower and higher rates is around 10 percent. The number of mutations retained in different learners also varys from one to 41. Conclusions. The more recent Super Learner methodology combining the prediction of many learners provided good performance on our small dataset.AIDS research and treatment 04/2012; 2012:478467. DOI:10.1155/2012/478467
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ABSTRACT: To compare the frequency of the selection of the M184V/I resistance mutation in HIV-infected patients who experienced virological failure while receiving emtricitabine (FTC) or lamivudine (3TC), administered with tenofovir disoproxil fumarate (TDF) and either efavirenz (EFV) or a ritonavir-boosted protease inhibitor (PI; lopinavir or atazanavir). Patient data held at two clinical centres in France were analysed retrospectively. Eligible patients had experienced virological suppression (plasma HIV RNA <200 copies/mL) for ≥ 6 months before experiencing their first virological failure (at least two measurements of plasma HIV RNA ≥ 200 copies/mL). Of the 880 patients eligible for the study, 278 patients had experienced virological failure while receiving FTC + TDF + ritonavir-boosted PI, 257 while receiving FTC + TDF + EFV, 178 while receiving 3TC + TDF + EFV and 167 while receiving 3TC + TDF + ritonavir-boosted PI. Proportions of patients harbouring the M184V/I mutation were 24% (n = 62) for those who received FTC + TDF + EFV versus 51% (n = 91) for 3TC + TDF + EFV (P < 0.0001; Fisher's exact test); proportions were 11% (n = 30) for FTC + TDF + ritonavir-boosted PI versus 22% (n = 37) for 3TC + TDF + ritonavir-boosted PI (P = 0.002; Fisher's exact test). The use of lamivudine versus emtricitabine (P = 0.001), non-nucleoside reverse transcriptase inhibitors versus ritonavir-boosted PIs (P = 0.01) and the level of viral load at the time of virological failure (P = 0.01) were associated with selection of the M184V/I mutation (logistic regression analysis). Emtricitabine and lamivudine showed differing resistance profiles when administered in combination with tenofovir disproxil fumarate and either efavirenz or a ritonavir-boosted PI. The prevalence of the M184V/I resistance mutation was significantly lower in patients who received emtricitabine and tenofovir disoproxil fumarate than in those who received lamivudine and tenofovir disoproxil fumarate.Journal of Antimicrobial Chemotherapy 02/2012; 67(6):1475-8. DOI:10.1093/jac/dks047 · 5.31 Impact Factor
Top Journals
Polytech Paris-UPMCLutetia Parisorum, Île-de-France, France
Université Paris 13 NordÎle-de-France, France
French Institute of Health and Medical ResearchLutetia Parisorum, Île-de-France, France
ANRS - Agence Nationale de Recherche sur le Sida et les hépatites viralesLutetia Parisorum, Île-de-France, France
Pierre and Marie Curie University - Paris 6Lutetia Parisorum, Île-de-France, France
Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
Lutetia Parisorum, Île-de-France, France
- Service de Virologie
Unité Inserm U1077Caen, Lower Normandy, France
Hôpitaux Universitaires La Pitié salpêtrière - Charles FoixLutetia Parisorum, Île-de-France, France
Hôpital Bichat - Claude-Bernard (Hôpitaux Universitaires Paris Nord Val de Seine)Lutetia Parisorum, Île-de-France, France
Chelsea and Westminster Hospital NHS Foundation TrustLondinium, England, United Kingdom


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Thursday, Jan. 6
Midway at Lenoir City (Middle School)
Oliver Springs at Harriman (Middle School)
North Middle at Cherokee (Middle School)
The Tennessee Wildlife Resources Agency reminds the public the 2011 Hiwassee Crane Viewing Days will be held on Jan. 15-16.
After taking a couple of weeks off for Christmas break, the Midway Middle School Green Waves and Lady Waves returned to action Monday evening.
The first game of the evening was a nail-biter as the Lady Waves rallied in the fourth quarter for a 36-35 victory.
The Tellico Plains Lady Bears used 30 team steals to cruise to a 70-21 win over the Midway Lady Waves Monday night.
Ten 3-point baskets helped the William Blount Lady Governors take a 65-42 victory over the Kingston Lady Jackets on Thursday.
Kingston scored the first seven points of the game, but the Lady Governors were not overwhelmed by the their opponent's good start. They outscored Kingston 14-2 the rest of the period.
William Blount had a solid second quarter and led 28-16 halftime.
Things got worse for Kingston after halftime and it trailed 50-28 at the end of the third quarter.
A 22-point deficit was too much for the Kingston Lady Jackets to overcome as they fell to the Dresden Lady Lions 53-47 at the Lenoir City Holiday Classic. Kingston had an 11-9 lead at the end of the first period, but a 21-5 Dresden run in the second quarter made the score 30-16 at half-time.
Dresden started off the third period on an 8-0 surge, but the Lady Jackets came swarming backwith a 12-4 tilt to make the score 42-28 at the end of the third period.
Tuesday, Dec. 28
Game 1 10:00 Berean vs. Gibbs (Girls)
Game 2 11:30 Berean vs. Gibbs (Boys)
10:00 Meigs Co. vs. South Sumpter (Girls)
11:30 Meigs County vs. Wartburg (Boys)
1:00 Rockwood vs. Knox West (Girls)
The Midway Lady Waves started off on a roll, but following an 11-3 tilt in the second period, Midway never recovered and the Monterey Lady Wildcats wound up surfing past the Midway Lady Waves 47-35 Tuesday evening.
Copyright © 2015
The Roane County News is your source for local news, sports, events, and information in Roane County and Kingston, Tennessee, and the surrounding area.


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I want to travel to cuba middle of april for about 10 days-- what is the best way to go about it-- preferably with a class for heavy duty instruction in percussion- i am a drummer--- any help or guidance will help - i would prefer to go with a license- is that possible??? thank you all for your time
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I can't say enough about Fattoria La Torre. Location and staff was perfect. In fact if not for our experiences there one might say our long awaited trip to Italy would have been a bust. Our entire trip paralelled a winter snow storm unlike seen in 50 years. The CInque Terre was like a ghost town. Siena felt like the antartic. Train stations closed. In many places in the Tuscany region chains were advised on tires. Hope this is making my point that if not for the wonderful hospitality, including no charge aperitif's more than once and johnny on the spot taking care of our needs, our trip would have been less than enjoyable. I can definately recommend taking the cooking course there at the agriturisimo. Chiara and staff made for a warm and comforting evening and delicious food and wine.
Italy is definately a redo for us and Fattoria la Torre will be as well.
- Also Known As:
- Fattoria La Torre Montecarlo, Italy - Province Of Lucca


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All square between Livepool and Everton at Goodison Park
- English Soccer
- October 4, 2015, 15:48
Everton 1 Liverpool 1 Liverpool manager Brendan Rodgers maintained his unbeaten record in Merseyside derbies but not with a performance likely (...)
Wayne Rooney under pressure to keep his England place
- International
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England coach Roy Hodgson can give Wayne Rooney "no guarantees" that he will always pick him for the national team and said the current crop of forwa(...)
Roy Hodgson says 'no guarantees' for Jack Grealish
- English Soccer
- October 1, 2015, 13:46
England manager Roy Hodgson says there's been no guarantees given to Aston Villa winger Jack Grealish that he will be called up into the English se(...)
Daniel Sturridge will need to be managed carefully
- English Soccer
- September 30, 2015, 13:41
Liverpool manager Brendan Rodgers admits Daniel Sturridge has to be handled carefully to ensure they do not "break" him again. The England internation(...)
Ken Early: Brendan Rodgers, rocket science and friction
- English Soccer
- September 28, 2015, 08:00
On Saturday, Liverpool beat Aston Villa thanks to two brilliant goals by Daniel Sturridge. 'It is not rocket science," Brendan Rodgers said. "The las(...)
Daniel Sturridge's Liverpool double eases pressure on Brendan Rodgers
- English Soccer
- September 26, 2015, 17:33
Liverpool 3 Aston Villa 2 Timing is everything and Daniel Sturridge's first goals for six months did his manager Brendan Rodgers a huge favour at Anfi(...)
Pressure mounting on Rodgers as Liverpool's woes continue
- English Soccer
- September 24, 2015, 23:15
Transition, transition, transition. It is the curse of modern football and also its great excuse. Whenever a club are underperforming, it is becaus(...)
Danny Ings impresses but Liverpool make it five without a win
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- September 20, 2015, 18:57
Liverpool 1 Norwich 1 Liverpool would have a new dimension with Daniel Sturridge back in the side, according to Brendan Rodgers, but only old failings(...)
Jordan Henderson out for two months
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- September 19, 2015, 12:43
Liverpool captain Jordan Henderson has broken his foot in training and is likely to be out for up to eight weeks. The 25-year-old England internationa(...)
Liverpool's Daniel Sturridge may return against Norwich
- English Soccer
- September 18, 2015, 01:00
ANDY HUNTER Brendan Rodgers has confirmed Daniel Sturridge and Jordan Henderson are in contention to face Norwich City on Sunday and that he expects L(...)


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Mariah Carey grabs top spot at Independent Records
Mariah Carey's Memoirs of an Imperfect Angel, released last week on Island, grabbed the top spot at Independent Records for the week ending October 4. Black Give Way to Blue, Alice in Chain's first album with new singer William DuVall, and Dethklok's Dethalbum II claimed the second and third slots, while Fiver Finger Death Punch's War is the Answer and Jay-Z's The Blueprint 3 rounded out the top five. See the full breakdown after the jump.
Independent Records
Top Sellers 10.04.2009
1. Mariah Carey - Memoirs of an Imperfect Angel
2. Alice in Chains - Black Give Way to Blue
3. Dethklok/Metalocaplypse - Dethklock/Dethalbum II
4. Five Finger Death Punch - War is the Answer
5. Jay-Z - The Blueprint 3
6. Breaking Benjamin - Dear Agony
7. Lil Rob - Love & Hate
8. Drake - So Far Gone
9. Insane Clown Posse - Bang! Pow! Boom!
10. Ghostface Killah - Wizard of Poetry
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The VA hosted an open house as part of its summer of service initiative. It's an effort to improve communication … Read More →
Dixon Cleared of Ethics Charges
A former Rapides Parish School Board president is cleared of ethics violations. Janet Dixon appeared with her attorney, Tommy Davenport, … Read More →
Students Volunteer at Cabrini Hospital
A group of high school students is spending the summer volunteering at St. Frances Cabrini Hospital. Besides their age, they … Read More →
Rapides Clerk Prepares to Offer Same-Sex Marriage Licenses
By this afternoon, the Rapides Parish Clerk of Court, like all the others in the state, are prepared to offer … Read More →
Gas Prices Begin Falling After 2 Months of Hikes
Gas prices are falling after more than two-months of big price hikes. The Lundberg Survey reports over the past two … Read More →
The Good Book-Mobile Schedule Change
The Good Book-mobile has been running since the end of May and some changes have been made to the schedule … Read More →
Upward Bound Program Preps Students for College
If you were wondering how to give your high-school student an edge in science and math, perhaps you should check … Read More →
Safe Sitter Class Teaches Detailed Child Care
Rapides Regional Medical Center is providing a safe sitter class. Organizers say the goal is to teach babysitters detailed child … Read More →
Leesville Woman Arrested for Murder
Vernon deputies arrest a 30-year-old Leesville woman for murdering a man yesterday morning. Deputies say Amber Lisotta admitted she used … Read More →
Jindal Announces Run for Presidency
Governor Bobby Jindal makes a big announcement. After serving Louisiana for nearly two terms, Governor Jindal is now eyeing the … Read More →


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The Gerontological Society of America (GSA) has named four researchers affiliated with the Harvard Center for Population and Development Studies as the recipients of the Richard Kalish Innovative Publication Awards for their paper published in the American Journal of Public Health on the innovative use of sequence analysis as a exposure assessment tool for life course research. Erika Sabbath, ScD, who is lead author on the study and was a visiting scientist at the Harvard Pop Center, collaborated with Pop Center research associate Iván Mejía Guevara, PhD, faculty member M. Maria Glymour, ScD, and Director Lisa Berkman, PhD. The distinguished awards will be presented at GSA's 68th Annual Scientific Meeting in Orlando, Florida in November. Learn more in this EurekAlert.
Tag Archives: Lisa Berkman
Length of time spent in retirement impacts some measures of social engagement
Recent Harvard Pop Center Fellow Erika Sabbath, ScD, and Pop Center Director Lisa Berkman, PhD, are co-authors on a study published in European Journal of Ageing that suggests that disparities in social engagement may become apparent across the retirement transition.
Job stress that impacts family life linked to increased cardiometabolic risk
A WFHN study of nursing home employees found that job stress that impacts family life (work-to-family conflict) is linked to increased cardiometabolic risk, whereas being married and having younger children at home was protective against this increased risk. Lisa Berkman is lead author on study, published in the Journal of Occupational Health Psychology, which also found that family conflict that impacted work life (family-to-work conflict) was associated with getting less sleep.
Single motherhood before age 50 linked to poorer health later in life
Harvard Pop Center Director Lisa Berkman, PhD, is lead author on a study published in the Journal of Epidemiology & Community Health that found that single motherhood before the age of 50 was associated with poorer health in later life. The association was stronger in England, the US, Denmark, and Sweden than in some of the other countries, such as those in Southern Europe, suggesting that social supports (e.g., a strong family network) may play an important role. Co-authors include Harvard Pop Center faculty members Maria Glymour, PhD, and Mauricio Avendano, PhD, and former Pop Center Fellow Erika Sabbath, ScD. The study is receiving international media attention including this article in The Telegraph and this spot on the Today Show on NBC. It is also the subject of this news brief from the Harvard. T.H. Chan School of Public Health.
Lisa Berkman on link between maternity leave & mental health featured in Harvard Chan School's The Big 3
The Harvard T.H. Chan School of Public Health's news feature The Big 3 asks Pop Center Director Lisa Berkman, PhD, three questions about a recent paper that found that women who received more generous maternity leave benefits with their first born child experienced better mental health that extended in older age. Other co-authors of the study, published in Social Science & Medicine, include Pop Center faculty member and former Bell Fellow Mauricio Avendano, PhD, along with Giacomo Pasini, PhD, who was a visiting scientist at the Harvard Pop Center during the month of January.
Berkman to appear on panel of "The Vow Factor" Congressional Briefing April 17
Lisa Berkman, PhD, the director of the Harvard Pop Center, will be a panel member at a congressional briefing entitled "The Vow Factor: Marriage, Divorce and Family Formation and their Impact on Health and Well-Being" at the U.S. Capital Visitor Center on Friday, April 17 from noon – 12:30 p.m. The congressional briefing is sponsored by The Population Association of America, and the Association of Population Centers, and is open to the public. RSVP by April 15.
Call for institutions to adapt to support older age workers & more productive society
Harvard Pop Center Director Lisa Berkman, PhD, and faculty member Mauricio Avendano, PhD, have co-authored a paper published in Daedalus that examines the challenges and opportunities posed by an aging U.S. population, particularly as it relates to an aging workforce.
Is education a factor in mortality gap between U.S. & Europe?
Harvard Pop Center Director Lisa Berkman, PhD, and faculty member Mauricio Avendano, PhD, are co-authors on a study published in the American Journal of Public Health that suggests that the larger educational disparities in mortality in the United States partly explain why US adults have higher mortality than their European counterparts. Although more evidence is needed, the study suggests that policies to reduce mortality among the lower educated could be necessary to bridge the mortality gap between the United States and European countries.
Lisa Berkman speaks on NPR's Here & Now on American Workplace Policies
Harvard Pop Center Director Lisa Berkman shares findings from the Work, Family & Health Network intervention study with Robin Young in this NPR story that aired on Here & Now. This news story, "Are American Workplace Policies Stuck in the 1950s?," is part of NPR's focus this month on what factors shape health, the topic of a recent poll by NPR, the Robert Wood Johnson Foundation, and the Harvard T.H. Chan School of Public Health, as well a recent Forum panel discussion.
Can we learn about mortality risk by comparing data from self-reports vs. claims on heart attacks?
Three Harvard Pop Center researchers, including research fellow Laura C. Yasaitis, PhD, Pop Center Director Lisa Berkman, PhD, and faculty member Amitabh Chandra, PhD, have published a study in Circulation, the journal of the American Heart Association, that compares self-reported data to administrative data (Medicare claims) on acute myocardial infarction events.


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Construction and Engineering
Company Overview of NCC Real Estate LLC
Company Overview
NCC Real Estate LLC engages in the development and construction of residential and commercial properties, industrial facilities and public buildings, roads, civil-engineering structures, and other types of infrastructure. It also engages in the production of input materials used in construction, such as aggregates and asphalt; and offers paving and road services. In addition, the company operates as a general project designer. NCC Real Estate LLC is based in St. Petersburg, Russian Federation. It has operations in the Scandinavian countries, the Baltic region, and Germany. NCC Real Estate LLC operates as a subsidiary of NCC AB.
Shpalernaya st, 54
St. Petersburg, 191015
7 812 329 9225
7 812 329 9223
Key Executives for NCC Real Estate LLC
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D.C. Delegate Eleanor Holmes Norton lambasted the Secret Service for its "massive failure" in managing the tens of thousands of people who attended Wednesday's 50th anniversary event of the March on Washington.
In her letter Thursday to Secret Service Director Julia A. Pierson, Mrs. Norton criticized the agency for its poor planning and preparation in designating a single entry point for the general public. Long wait times combined with temperatures in the upper 80s led to an uncomfortable experience for many attendees.
"It is inexcusable that people had to wait on their feet for long hours in such hot and humid conditions," Mrs. Norton said in her letter. "The congestion at the security check point at the general public entrance to the event caused huge lines and wait times, which left visitors, many of them elderly, frustrated and even ill and overcome by the heat and rain."
At the height of Wednesday's bottleneck, the Secret Service released a statement saying it was aware of the delays and was "working diligently to process people as quickly as possible through the checkpoints."
About halfway through the anniversary event at the Lincoln Memorial and with wait times of as much as 2 hours, officials added two additional magnetometers to the nine originally in place and opened other entry points where they conducted bag checks and operated hand-held metal detector wands.
Mrs. Norton called the additions belated and said that they only served to point out that "with routine, advanced planning, the misery your agency caused could have been avoided."
"I am well aware of the standards for effectively controlling large crowds, which your agency is capable of meeting," the District's nonvoting member of Congress said. "I am, therefore, very disappointed that you failed to prevent an organizational breakdown that was entirely unnecessary."
In a statement released Thursday evening the Secret Service said "every effort was made to adapt with resources and personnel to accommodate the surge in attendees that arrived after 11 o'clock for security screening. Throughout the entire event, we continued to process people to make sure that everyone that wanted to attend the event was able to attend."
The agency charged with protecting the president and other dignitaries, said it will conduct an after-action review with the National Park Service to see if there are areas for improvement.
Gates opened at 9 a.m. for the general public security checkpoint at the entrance to the World War II Memorial. Within an hour, the security tent was choked, with some people leaving from frustration or discomfort.
The D.C. fire department provided medical assistance to more than 100 people and transported seven people to hospitals. Most ailments were heat-related, department spokesman Oscar Mendez said.
The lines eventually thinned by the time former Presidents Jimmy Carter and Bill Clinton took the stage at about 2:30 p.m., and for the address by President Obama shortly after 3 p.m.
Agents continued to search attendees even as Mr. Obama concluded his address, while several hundred people chose to simply watch the event from outside the checkpoint.
Mrs. Norton in her letter requested a meeting with Ms. Pierson to discuss the breakdown.
"There is no doubt that the many failures could have been prevented," she said.


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Select Local Merchants
Princivalli's CafeRead MoreFor a mouthwatering meal you're sure to love, Princivalli's Cafe in Alton is the place to be. Low-fat food isn't on the menu, so diners come to Princivalli's Cafe to enjoy their every bite. Order a bottle for the table if you like — Princivalli's Cafe has a full bar stocked with the best wine, beer, and more. Bring your whole brood to Princivalli's Cafe, where families can dig in to tasty and kid-friendly fare together. Your group can sit comfortably at Princivalli's Cafe, a local restaurant. Enjoy wifi here free of cost. Leave the fancy duds at home — patrons at the restaurant dress informally. If you're strapped for time, take out food from Princivalli's Cafe. Princivalli's Cafe is known for serving great food, and they are able to serve it at your next event with their excellent catering. If preferred, patrons can leave their vehicles in a nearby lot, though space is available on the street as well. You'll typically spend about $30 per person to dine at Princivalli's Cafe, so plan your budget accordingly. Breakfast, lunch, and dinner are all available at Princivalli's Cafe.602 E 3rd StAlton, IL US
Pizza HutRead MoreWhether you are looking for a slice of pizza or a whole pizza pie, Alton's Pizza Hut offers a wide variety of pizza types and sizes. Calling all gluten-free and low-fat diners! Pizza Hut has a multitude of dishes right up your alley that are freshly-prepared and taste amazing. Catering from Pizza Hut will take your party to the next level. Enjoy mind-blowing dishes in the peace and quiet of your own home with delivery or takeout from Pizza Hut. Parking can be a pain in the neck, but it's as available as ever near the pizzeria. When you need a good meal in a flash, grab a pizza from the highly-rated Pizza Hut.3096 Homer M Adams PkwyAlton, IL US
Pizza HutRead MoreIf you are in search of a good meal that won't empty the wallet, then look no further than Pizza Hut on Homer M Adams Pkwy. Come in for the good quality and stay for lightning-fast service. You'll be a repeat customer in no time. While the prices may be low, you can bet that the ingredients will be fresh. If you don't feel like driving over to Homer M Adams Pkwy, placing a delivery order is an option. One of the better pizza chains in the area, this particular Pizza Hut is definitely the place to gather 'round the good stuff.70 Homer M Adams ParkwayAlton, IL US
Little Caesars PizzaRead MoreAt Little Caesars Pizza, guests can expect one of the more inexpensive meals in Alton. Stop in for the great quality and stay for lightning-fast service. You'll be planning your next trip to Little Caesars before you know it. While the prices may be low, you can bet that the ingredients will be fresh. If you don't feel like driving over to State, placing a delivery order is an option. A dependable favorite in Alton, a trip to Little Caesars is definitely worthwhile, no matter how you slice it.2410 State StreetAlton, IL US
Caseys Carry Out PizzaRead MoreAt Caseys Carry Out Pizza, guests can expect one of the better-priced meals in Alton. Stop by for the great quality and stay for helpful service. You'll be a repeat customer in no time. While the prices may be low, you can bet that the ingredients will be fresh. If you don't feel like eating in, you can always grab your food to go, or just place an order for delivery. A pizza franchise with nearly 60 years of success, Caseys definitely won't leave you disappointed, no matter how you slice it.3499 Fosterburg RdAlton, IL US
Little Caesars PizzaRead MoreCraving pizza? Head on over to Alton's Little Caesars Pizza for a tasty slice with a crust you can't resist. Little Caesars Pizza is also a good option for those with special dietary needs, offering both low-fat and gluten-free items on the menu. Driving to the pizzeria is easy as pie, and parking surrounds the area. So grab a slice of pizza or two from Little Caesars Pizza and enjoy a great lunch or dinner.1601 Washington AveAlton, IL US


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Edinburgh Night Walking Including Historic Underground Vaults
Read what other Viator.com travelers think about the Edinburgh Night Walking Including Historic Underground Vaults. What they loved, what they liked and what they think could be improved, it's all here to help you make the most of your next trip.
Click here for tour details, schedule and pricing
Enjoyed the tour and the guide Nicol was outstanding.
SO fun! This was one of the things we were looking forward to the most and it didn't disappoint. Would recommend it.
Great tour! I would definitely recommend it to anyone who is interested in the ghost stories as well as the history of Edinburgh.
GREAT, so glad we did this tour. My daughter inlaw was convinced she saw something, a little restless night but all fine. loved our tour guide who kept in character - very clever.
Our tour was amazing! Really gives you an idea of how some people worked and lived! Our tour guide Lydia was amazing! She is a wealth of knowledge!
Absolutely brilliant, thoroughly enjoyed ghost stories and tour of vaults. Very atmospheric, chilling and exciting, Mark was brilliant as tour guide. Would not hesitate recommending this tour, well worth it. Made a fantastic start to our weekend in Edinburgh.
Tour 3rd July 2015 9.30 pm.
This tour was amazing! Our tour guide, Lyndia was perfect. She made the tour informative, entertaining and scary. This tour is definitely one to remember. I highly recommend this tour.
Wonderful tour for the price
This tour is simply brilliant. The places you are taken and the stories behind them are fascinating as well as creepy. Our tour guide Craig was the best story teller, and supplied not only great ghost stories but extremely interesting facts about the history of Edinburgh. 10/10 would recommend
Great fun. The tour guides were full of info and I enjoyed all the creppy stories. Definitely a must if your in Edinburgh.
tour guide ella was fantastic really knows her stuff
and loves to get really into the story and gets everyone involved,
The vaults are brilliant really scary at night time highly suggest you go on the night tours as they highten the atmosphere
definetly worth every penny
Fantastic tour
Great tour guide and great stories
Tour was great :) highly recommend!
Craig who took us on the tour is a very good story teller with a mix of history and ghost stories. We all had a good time with some frights !!!!
Enjoyed the history, walking under the city and into the vaults, the male guide new his stuff but several times found it hard to understand and hear to what he was saying which was a bit disappointing, however would visit the tour again.
great tour dont miss
knowledgable tour guide very entertainign and interesting tour
This was a fun bit and our tour leader excellent.
Absolutly brilliant james the guide was amazing well recommand
Our tour guide was amazing. He was full of action and suspense. His story-telling abilities were second to none. He gave us great insight into the gloom of days past and underground vault activities.
Great experience, we loved it.
So awesome!!! Our guide was Alex and he was so amazeballs!!! Absolutely made the tour what it was :D
This was a really fun tour, and I wish I had done another your with Mercat. John was our tour guide, he was great at telling the Scottish ghost stories. It was very nice to walk around Scotland hearing about the history, and then walking into the vaults and hearing ghost stories. It was really fun.
Tour guide was exceptional and the stories were brilliant and spooky. Would definately recomend if your in Edinburgh


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25th Anniversary
25th Anniversary project diary
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Mantle Community Arts work creatively with people of all ages and from all walks of life; reaching out to groups through working in partnership with a whole range of organisations and venues.
The last session was the first vital step in my learning to read out my own (poetry) work in public in preparation for the publication of my first collection some time next year.
HeadSpace Poetry participant - Dec 08
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Don't let other travellers get your favourite Blairgowrie holiday home. You're so close to securing your perfect getaway. Book today.
Holiday watermill in Blairgowrie
Perth and Kinross / Blairgowrie
Watermill / 3 bedrooms / sleeps 6 / 7 nights min stay
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£550 - £920 / week
Key info: Beach / lakeside relaxation; Great for children of all ages ; Car advised;
25 Jul 2014
"The perfect stay for a relaxing holiday"
We have recently stayed at Brooklinn mill the jute store and was so impressed with our stay we want to tell you all about it. On our walk through the front door this has the WOW factor it's on 3 leve… More
5 Oct 2013
"A Little Slice of Perthshire Perfection"
We fell in love with The Jute Store when we first saw it on the web site while planning our 2013 trip to Scotland and, to be honest, it was the sole reason for us choosing to stay in Blairgowrie. Usua… More
Thank you so much for your great review. It is very nice to have our efforts appreciated! I totally agree that one of the best things about the Jute Store is the feeling that you are miles away from anywhere, but Blairgowrie is only just a mile away! Thank you again.
5 Jul 2013
"Beautiful holiday home with stunning views"
Beautiful cottage with stunning views over the river Ericht. If I had to imagine what an ideal Scottish holiday home would be like, this would be pretty close to the mark. Great kitchen and facilities… More
Thank you very much for your review. We are so pleased you enjoyed your stay and hope to see you all back again soon!


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SignCraft features articles by and on real-life professional sign makers and shop owners—not canned, generic articles meant to fill space. For over 30 years we've been been helping sign shops be more effective, more successful and more profitable. We're sign people, not publishers, and our goal is to help you make better signs and make them more profitably.
Every issue issue of SignCraft delivers practical, straightforward information that's hard to find anywhere else:
How do you make it? Watch for how-to articles that show how efficient sign makers cut production time, create more powerful layouts, produce creative effects, and get the most out of software, equipment and materials.
What's it cost to make it? In every issue, a sign professional follows an everyday sign project through from start-to-finish, tracking the time and materials involved. Flat signs, vehicles, 3D signs, monuments—all types of signs get covered. See photos of each step, and hear how they sell the job.
How do you price it? You'll find pricing and sales help in every SignCraft. In our Design & Price feature, several successful sign pros tackle the same project, give a selling price and explain how they would sell it.
Where do you get the ideas? Easy—from seeing plenty of outstanding sign work of every type by experienced, successful sign designers and shop owners. SignCraft takes you right to their shops, shares their ideas and shows you loads of photos—well over 100 per issue.
Subscribe today and you'll get our annual Sign Pricing Guide FREE, a $23.95 value--plus instant access to the online sign price calculator, where you can price everyday signs in just three clicks!
The ValueJet 405GT from Mutoh America, Inc., prints t-shirts and other apparel at 1200dpi resolution for maximum detail. It features a wide print area but a tabletop footprint, and five ink color capability including white. The MSRP is $19,995 and it is available through authorized Mutoh resellers. www.mutoh.com/dealers
Hand lettering signs is satisfying, profitable and fun. Here's your chance to learn how from veteran sign painter Mike Meyer. Workshops are scheduled for the US, UK, Europe and Australia. Don't miss it!
Every issue of SignCraft brings you over 150 idea-packed photos. Here's a sampling from our recent issues. Simply click on any image to enlarge it.


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Plan Your Weekend
Get our weekly guide to the best local family events!
Timothy Chase, D.M.D., shares the best and worst Halloween candy for your children to eat to maintain good oral health at Halloween.
This traditional Mexican celebration, also known as Dia De Los Muertos, is happening in family-friendly ways all over town.
The Rev. Victor Fuhrman is a real-life ghostbuster, meaning he investigates the paranormal and communicates with ghosts.
If your kids like a little spookiness along with their tricks and treats, this list of scary (but not too scary!) Halloween movies for kids and families compiled by Common Sense Media is sure to hit just the right note.
Let's face it, Halloween just isn't Halloween without jack-o'-lanterns. But with little kids in the house, carving pumpkins might be on your "to avoid" list. We've gathered our favorite no-carve pumpkin ideas that kids can do or help with to make your own Halloween decorations.
Katie Wyllie, author of Kids' Treats: 50 Easy, Extra-Special Snacks to Make with Your Little Ones, gives us the treat of three delicious recipes to make with marshmallows this Halloween.
Halloween is quickly approaching, and what better way to celebrate the holiday than by making your own Halloween decorations, and accessories for your costumes? Here, a roundup of our favorite Halloween DIYs.
Whether you're looking for something spooky or just outdoor fall fun, these haunted houses, corn mazes, pumpkin blazes, and autumn activities in New York, Long Island, and Connecticut are sure to make this Halloween one to remember.
Local parents share smart solutions to the trick-y troubles that seem to haunt us all in October.
Happy Halloween! For younger kids and babies, trick-or-treating is a new experience and it can be a little frightening or overwhelming if they aren't prepared for what's to come. Make sure baby stays warm and comfy for a smooth experience with these seven tips and tricks for your Halloween night out.
Audrey Kinsman, mom of four, recently launched "Switchcrafted: The Story of the Switch Witches of Halloween", a book that encourages kids to trade in their Halloween candy for a new toy or other treat.
Fall is one of the most breathtaking times to visit Bucks County, Pennsylvania. Discover fun family-friendly events to celebrate autumn—and a few on the spooky side for Halloween!
Liz Heinecke, author of Kitchen Science Lab for Kids, shares easy-to-follow directions to make Alien Monster Eggs for a Halloween decoration for your ghoolish party. Bonus: It's a science experiment for kids!
If you're celebrating Halloween in Fairfield County, CT, with a toddler or young child, check out our guide to fun, tot-friendly, not-too-scary Halloween events in the area, including costume parties, outdoor events, and much more.
If you're celebrating Halloween on Long Island with a toddler in tow, check out our guide to tot-friendly, not-so-spooky events in Nassau and Suffolk counties, including trick-or-treating events, costume parties, and museum celebrations.
There are plenty of FREE events celebrating Halloween on Long Island. Our guide includes family-friendly festivals, trick-or-treating events, museum parties, community celebrations, and more.
Your guide to free things to do for Halloween in New York City, including family festivals, carnivals, costume parties, spooky story times, and much more in the five boroughs.
Looking for things to do for Halloween with your toddler in New York City? We've put together a list of tot-friendly Halloween events in the boroughs, including costume parties and museum events that welcome young children.
We've answered your frequently asked questions about the 2014 NYMetroParents Halloween Photo Contest. Find out how to enter your child, information on how the winners are chosen, voting policies, and cover contest prizes from UrbanSitter and KidzBop!
Master pumpkin carver Thomas Olton, creative director of the annual Rise of the Jack O' Lanterns at Old Westbury Gardens on Long Island, gives tips on how to carve pumpkins with your kids in a fun, safe, and easy way.
Get into the Halloween spirit with these fun Halloween crafts for kids, many of which can be created from materials you have laying around the house. These cool and creepy DIY projects also make great Halloween decorations for your home.
Fall means cooler weather, pumpkins a-plenty, ghosts and goblins, and of course, Halloween! Kids may automatically associate Halloween with candy, but there are other, more healthy ways to celebrate the holiday. Here, family food expert Laura Fuentes shares tips and tricks for a fun, healthy, and active Halloween season with your family.
Jennifer Chung, founder of Kinsights, shares her ideas for hosting a Halloween party, including Halloween decorations, Halloween-themed food, and Halloween activities.
In preparation for the "spooktacular" holiday of Halloween, Better Business Bureau Serving Metropolitan New York urges consumers to exercise caution when shopping for holiday deals. Follow these tips to avoid costly shopping mistakes.
The annual Halloween Candy Buy Back program is back to shine for another year. The program will partner with dentist offices nationwide to collect children's Halloween candy to send to the troops overseas along with toothbrushes and necessary oral care items.


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Select Local Merchants
CR Resource Contracting Inc.Read MoreCR Resource Contracting Inc. helps homes and businesses lower their energy bills by using energy more efficiently. Staff members conduct energy audits on each of their clients to determine where most of the energy is going and how best to save it. Then, they devise a green strategy suited to their clients' goals, which can involve simple light-bulb swaps or more involved tasks such as solar-panel installation.5925 Fair Oaks Blvd # 7Carmichael, CA US
Run or DyeRead MoreRun or Dye is making race running a little more colorful, one major city at a time. This 5K is divided up into four separate courses of varying lengths, each designated by a separate color—which also reflects the color of safe, eco-friendly powered dye the participants get splashed with. At the end of the race, they'll cross into the aptly named Dye Zone—a polychromatic free-for-all where fluorescent color is thrown freely from all sides, allowing runners to splash their fellow runners or get colorful revenge on their friends, family members, and any cranky art-history teachers that happen to be walking by. Unlike some races that rank runners by time, Run or Dye only measures success in color and fun. While the safe-to-eat dyes should wash out of clothing, runners are encouraged to wear things they don't mind getting dirty, preferably in white, gray, or another neutral color to give the dyes maximum visibility.3140 Peacekeeper WayMcClellan Air Force Base, CA US
THOMPSON MECHANICALRead MoreDon't let problems around the house persist when you can show your living space the TLC it deserves and call THOMPSON MECHANICAL's handyman service in Elk Grove. Get your home ready for the harsh summer heat and bitter winter cold with a quality A/C and heating systems inspection from THOMPSON MECHANICAL. When something needs fixing, you can count on the folks at THOMPSON MECHANICAL to help you out.10620 Halfway RdElk Grove, CA US
Monk and Associates Biological ConsultantsRead MoreKeep your little one active and happy all day long with some child care services from this store. Create a safe haven for your new baby with some of these nursery furniture items from Monk and Associates Biological Consultants. We all know that children outgrow clothing pretty quickly. At Monk and Associates Biological Consultants, you can find affordable and fashionable clothing for your growing baby and toddler. There are many parking spaces available for customers.1136 Saranap AveWalnut Creek, CA US
Kyle DesignRead MoreFind durable, stylish and affordable home furnishings at Kyle Design in Livermore and give your home a makeover. Brighten up your walls with the great pieces here including mirrors. Doll up your house with a little help. Items like vases may be just the snazzy solution your home needs. Many parking options are available in the area. Kyle Design in Livermore offers the best deals on furniture so stop by today and find a new piece for your home.468 Lindbergh AvenueLivermore, CA US


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We love it with...
Claudia - Peridot for August - Birthstone is rated out of 5 by 6.
Rated 5 out of 5 by valenk from Pretty glitter polish I was leary of this polish at first when I saw it...I'm not usually a fan of green polishes. But I was pleasantly surprised! When applied in a thinner coat, it is more of a gold with some green accents. I don't know that I would like it as a thick coat though. I did top a couple of nails with it over Erin (a gray creme) and LOVE the look of the two together.
Date published: 2014-09-17
Rated 3 out of 5 by Lunaxcat from Pretty but.. This polish is really pretty. I love the color and the glitter and was super excited to try it out! However, after one day the entire polish has "fallen off" my thumb and forefinger. Just fell right off. I have not been in contact with any chemicals, or washed dishes. It's very weird. I'm a little disappointed, as this polish is gorgeous and wanted to wear it for a while.
Date published: 2014-08-26
Rated 5 out of 5 by Peach from Pretty peridot This is a really pretty stardust-like polish with rainbow microglitter and some larger dark green glitter in it as well. One coat gives a more subtle but still lovely glittery effect, and two coats gives the color more depth. I really like this polish! :)
Date published: 2014-08-05
Rated 5 out of 5 by Nicola from Perfect! My hubby's birthstone is peridot and this polish is a perfect match to the stone colour! Love!!
Date published: 2015-07-10
Rated 4 out of 5 by Audi5k from Love the Color! Have wanted my birthday month nailcolor for quite a while and plan to wear it all month long in August, starting with my toes.
Date published: 2015-06-11


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Prep Football on NewsRadio WGNS
FRIDAY: Haywood Co. at Oakland
6pm pregame, 7pm kickoff
For Sale: 3 vintage old Coca Cola trays $45 each; 17 metal toy cars; bench grinder $25 617-3586
For Sale: Virgin mobile phone $15; Event: VBS 6PM all this week at 4745 Leanna Rd. (Center of Hope Church) 707-3328.
Wants: Thomas The Tank toys 556-7089
For Sale: old Kenmore sewing machine (runs great) $75; oak TV cabinet that holds 40-inch TV, games and more $100 568-2698
For Sale: 1991 Chevy S-10 967-5162
For Sale: car top carrier; chain link fence 578-7991
For Sale: new 1999-2004 Mustang hood; Murray 38-inch, 11HP riding mower 979-2408
For Sale: cordless phone $10; Dell color printer, scanner, copier, FAX $10; table lamp 890-0707
For Sale: Ford 2001 Sport Truck $3,000 (wants larger truck to pull trailer), power brakes and locks (may trade for larger truck) 566-7386
Yard Sale: this Friday and Saturday at River Rock Condominium (7AM-3PM), across from Old Time Pottery 895-4535
For Sale: 3 brass floor lamps with shades $20 each 542-1873
For Sale: antique iron baby bed (over 100 years old) 896-8506
Catch the Prentice Alsup Heating and Air Coaches Corner every Saturday morning. Bryan Barrett, Jon Dinkins and Monte Hale, Jr. will broadcast each Saturday morning at 8:00am. It's followed by MTCS Cougar Corner at 10:15am.
RIVERDALE - 8:05am
SMYRNA - 8:25am
BLACKMAN - 8:40am
LA VERGNE - 9:00am
OAKLAND - 9:15am
STEWARTS CREEK - 9:30am
SIEGEL - 9:45am
EAGLEVILLE - 10:00am
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Three weeks ago, we warned of the upcoming Aaron Donald hype (warranted). ESPN put up their first...Rich Gapinski 10-08-2015 12:36 PM
I'm stubborn because I believe the Raiders are a good team, despite losing to the Bears and that...hobbes27 10-08-2015 12:14 PM
I'm stubborn and the Chargers aren't that good.
Going with the Bears
and yes No Upsets seems like a good call, but this is the NFL, some...
Shot in the dark... Gimme the Browns for no sane reason!Afrocomb 10-08-2015 07:41 AM
The Bears... again.
Great stat about Vegas being right on home dogs in similar situations.
I always have to remind myself than when you guys pick, it's with the spread and not straight up. Definitely like Baltimore getting 8 points, that's a pretty good deal given how the defense has been transformed in the playoffs. Frankly, I still can't absorb the change.
I also like the over in the SF game. I have a feeling Atlanta won't try to rush Copernicus, just contain him and see how well he throws into confusing coverages downfield. Frank Gore's role will be interesting. Matt Ryan figures to have reasonable time to throw. Justin Smith will be what he was last week, tendons don't heal that quickly.
I agree. Eight points is too much to lay against a Baltimore defense which is playing as well as they are right now and when New England has had as many problems beating the Ravens as they have recently. In the last four seasons, the Pats are 3-2 against Baltimore. In four of those five games (NE is 3-1), the combined margin of victory has been thirteen points (including an overtime game). In the other game, New England lost by 19 points on a Wild Card Sunday. Eight is way, way too much to put money on.
I really like San Francisco. I think this is the most talented team in the league.


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This medium sized sofabed from the Amelie range features a classic design, solid wood feet and a beautiful lilac finish. The seat and back cushions have a deep foam and fibre filling, offering a comfortable and supportive place to sit back and relax. The Amelie sofabed comes with 2 scatter cushions and a foam mattress that is suitable for occasional use only.
Catalogue Number: 723-0526
An adult will need to sign for this item.
Sorry, there are currently no sellers for this product.


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November Films - Snow White & The Huntsman
November 2, 2012
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Snow White is the only person in the land fairer than the evil queen who is out to destroy her. But what the wicked ruler never imagined is that the young woman threatening her reign has been training in the art of war with a huntsman who was dispatched to kill her. Charlize Theron, Kristen Stewart, Chris Hemsworth, Sam Claflin, Ian McShane, Bob Hoskins, Ray Winstone, Nick Frost, Sam Spruell, Toby Jones.2012, 132 Minutes, Color.
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