text:
Home > Electronics > Web Cams, Video Capture > Video Capture
IOGear Wireless Mobile and PC to HDTV
Usually ships in 5-7 business days. Limited availability. May not be in stock at time of order. No back orders.
IOGEAR's GWAVR allows you to enjoy all of your personal and online content your big screen HDTV wirelessly. Using your smart phone, smart tablet or laptop you can sit back and experience your favorite movies, videos, photos, online shows and more in full HD on your HDTV with great image clarity and sound.
Product Information
Mfr Part#
Ports and Connectors
Output Ports and Connectors
1 x HDMI
Video Input
Physical Specifications
Dimensions (WxDxH)
0.63'' x 9'' x 3.31"
0.2 lbs
What's in the Box
What's in the Box
1 x Wireless A / V Receiver 1 x Power Adapter 1 x Quick Start Guide 1 x Warranty/Registration Card
Included Hardware
1 x Wireless A / V Receiver
Manufacturer Warranty
1 Year
Important Add-Ons
Questions and Answers
More Info
Warranty & Support
Vendor Warranty:
- Parts: 1 Year
Vendor Support:
- Main Website: www.iogear.com/
- Support Website: www.iogear.com/support/
- Support Email: firstname.lastname@example.com
- Support Phone #: 866-946-4327
Micro Center Return Policy:
We guarantee your satisfaction on every product we sell with a full refund — and you won't even need a receipt.* We want you to be satisfied with your Micro Center purchase. However, if you need help or need to return an item, we're here for you!
If an item you have purchased from us is not working as expected, please visit one of our in-store Knowledge Experts for free help, where they can solve your problem or even exchange the item for a product that better suits your needs.
If you need to return an item, simply bring it back to any Micro Center store for a full refund or exchange.
*If you are a Micro Center Insider or if you have provided us with validated contact information (name, address, email address), you won't even need your receipt.
General Return Policy
Desktop / notebook computers, tablets, processors, motherboards, digital cameras, camcorders and projectors, 3D printers, 3D scanners, and CD/DVD duplicators may be returned within 15 days of purchase. All other products may be returned within 30 days of purchase. Merchandise must be in new condition, with original carton / UPC, and all packaging / accessories / materials. If you need to return software, a game or a movie, remember that you may not retain any copies — it's not legal, and it's not nice.
Wireless Phones & Devices
Wireless phones and devices may be returned within 14 days of purchase. When returning a wireless phone or device with a plan, you are responsible for ensuring that your service is cancelled with the carrier. If you don't cancel your service, you may incur additional charges from your carrier. All carrier charges are your responsibility.
Digital Downloads
All Digital Download sales are final and are not eligible for return or refund under the Micro Center Return Policy.
Using the software may require the use of a computer or other device that must meet minimum system requirements. It is recommended that you familiarize yourself with the system requirements before making your purchase. Software system requirements are typically found on the Product information specification page.
Aerial Drones
Micro Center is happy to honor its customary 30-day return policy for Aerial Drone returns due to product defect or customer dissatisfaction. Unfortunately, we cannot accept returns with damage due to pilot error. So let's be careful out there!
Refunds will be credited to the credit card or debit card account used for the original purchase.
Micro Center Support:
|Free Walk-in Tech Support
|As a service to our customers, Micro Center offers free in-store technical support. Stop in any of our store locations during regular business hours, and our expert staff will answer your computer questions or help you with issues regarding:
|Support from Home or Office
If you need help with hardware or software products purchased from Micro Center, please contact one of our knowledgeable tech support reps by live chat or email.
|Free assistance is available for the first 30 days on new purchases, excluding internal hardware installations or networking support. Your invoice reference number will be required for free assistance.
We accept the following credit cards: Micro Center VISA® credit card with WorldPoints® Rewards; VISA; MasterCard; American Express; Novus/Discover.
|Learn more about our exclusive Priority Care Program. You'll have access to our in-house Technical Support team of certified technology professionals trained to assist you on a variety of PC and Mac related support issues.


text:
Phoenix's "Reverse Trayvon Martin Case" Is Nothing Like Actual Trayvon Martin Case
Cordell Jude
Some media reports contend that a "reverse Trayvon Martin" case is about to be tried in Phoenix.
The thought is that national media outlets are ignoring the Phoenix case because the shooter, Cordell Jude, is black -- and that doesn't fit some sort of media plot. In reality, there's hardly anything the two cases have in common.
See also:
-Cordell Jude Charged in April "Self Defense" Killing of Daniel Adkins
In this case, a man with a mental handicap named Daniel Adkins was walking his dog on the night of April 3, 2012.
As Jude was pulling out of a Taco Bell drive-through near 51st Avenue and Baseline, he nearly hit Adkins, who was walking on the sidewalk, before Jude slammed on the brakes in time, according to police reports.
Adkins began yelling at Jude, and Jude would tell police that Adkins hit his vehicle with a bat, pipe, or some type of object of similar size. Jude told police that he shot Adkins after he took another swing at him from outside the car.
Somehow, the pipe or bat -- or whatever it was -- apparently either vanished into thin air or Jude made it up, because there was no such object found anywhere near Adkins' body. Police reports note that Jude's car sure didn't look like it had been bashed up by a pipe.
Jude told police that he thought he was in danger but didn't think he was going to be killed, according to the police report. A witness driving in the car behind Jude in the drive-through line told police that he saw Adkins swing at the car, but didn't see Adkins holding anything.
Jude said he didn't just drive away because Adkins' dog was in the way, which is interesting, because police reports indicate the leash was still in Adkins' hand when he died.
To some people, this apparently sounds like the Trayvon Martin case, except the shooter's black in this one:
That gives way too much credit to Jude. No bloody photographs of Jude after the confrontationare going to pop up, and we don't remember George Zimmerman claiming he was being attacked with a deadly weapon that never actually existed.
There was no conversation with police dispatchers before the shooting. Jude wasn't following Adkins around.
The cases are hardly anything alike, except for the fact that an unarmed person was shot and killed.
The theory that this is a "reverse Trayvon Martin case" is pathetic, really.
Jude's second-degree murder trial is scheduled to begin next month.
Send feedback and tips to the author.
Follow Matthew Hendley on Twitter at @MatthewHendley.
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss Phoenix New Times' biggest stories.
Sponsor Content
More News
- NAU Shooting Wasn't a "Real School Shooting," Many on Social Media Claim
Upcoming Events
Boston Bruins @ Arizona Coyotes Gila River Arena Oct 17 2015 7pmSat., Oct. 17, 7:00pm
Rage In the CageSat., Oct. 24, 6:30pm
Arizona Cardinals Game ZoneMon., Oct. 26, 2:15pm
Arizona Cardinals vs. Baltimore RavensMon., Oct. 26, 5:30pm
- Tickets
- Arizona Congressman Raúl Grijalva Announces Bill Banning Uranium Mining Near Grand Canyon
- Phoenix Police Release Video Lead in Murder of Transgender Woman

subset: commoncrawl


text:
Over the last ten years the City of Woodstock's Police Pension Funding has increased from 61.5% in 2002 to 68.5% in 2011. $7.2 million will have to come from taxpayers to fulfill the commitment made by recent city councils. … Continue reading
Category Archives: Woodstock Police
Woodstock North PE Teacher and Wrestling Coach Arrested by Woodstock Police for Affair with Female Student
According to the Chicago Tribune, Woodstock North High School teacher James B. Guttridge has been arrested at his home in Rockford for one count of Sexual Assault and three counts of Aggravated Criminal Sexual Abuse. The arrest was made by … Continue reading
Videos Used to Convict Cary Man Found of Criminal Sexual Assault of Minor Female Relative & Child Porn Possession
A press release from the McHenry County State's Attorney's Office: JURY FINDS CARY MAN GUILTY OF CRIMINAL SEXUAL ASSAULT AND CHILD PORNOGRAPHY Louis A. Bianchi, McHenry County State's Attorney, announces today that John "Jack" Reed, 35, of Cary, was found … Continue reading
Today, we move to the fourth installment on the motion filed by former Deputy Sheriff Zane Seipler's lawyer Blake Horwitz requesting sanctions against McHenry County Sheriff Keith Nygren for releasing confidential information. This is occurring in Seipler's Federal wrongful termination … Continue reading
A press release from the Woodstock Police Department: FATAL ACCIDENT INVESTIGATION Woodstock, IL – On Monday August 22, 2011 at 8:34 AM the Woodstock Police Department and the Woodstock Fire/Rescue District responded to the area just West of Route 47 … Continue reading
An idea I first heard in the fall of 2007 from Democratic Party candidate for County Coroner David Bachmann is taking over big time under the DEA's leadership. I first noticed the DEA program in New Jersey in September, 2010.. … Continue reading
Here's the press release from the State's Attorney's Office: KIRK LOCHER FOUND GUILTY FOR SHOOTING FAMILY DOG Louis A. Bianchi, McHenry County State's Attorney, announces that Kirk Locher was found guilty yesterday by a jury for the offenses of Aggravated … Continue reading
As I was heading to the McHenry County Courthouse complex for the Republican Party-sponsored Chicago Food Pantry food giveaway, a Woodstock Police car came screaming down Business 14 and turned onto Route 47. It was easy to tell that this … Continue reading
A press release from McHenry County State's Attorney: CHICAGO MAN FOUND GUILTY OF THREATENING TO RAPE AND KILL SEVENTEEN YEAR-OLD WOODSTOCK GIRL McHenry County State's Attorney Louis A. Bianchi is pleased to announce that Marcus Sessom was found guilty of … Continue reading
The following is a letter that Dr. Richard W. Gorski has sent concerning his son, Sergeat Steven R. Gorski and the treatment his son is receiving at the hands of Woodstock city government: Over one year ago Robert "coffee with … Continue reading


text:
|Publication number
|Publication type
|Application number
|Publication date
|Aug 11, 1998
|Filing date
|Nov 8, 1996
|Priority date
|Jun 19, 1996
|Fee status
|Publication number
|Cary J. Reich, Donald Wallace, Greg Dapper
|Original Assignee
|Fusion Medical Technologies, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (48), Non-Patent Citations (4), Referenced by (79), Classifications (21), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation-in-part of application Ser. No. 08/673,710, filed Jun. 19, 1996 still pending.
1. Field of the Invention
The present invention relates generally to surgical methods, and more particularly to methods for inhibiting tissue adhesion following surgical procedures.
Tissue adhesions occur frequently following surgery and may contribute to or cause compromised surgical results and post-surgical complications. Tissue adhesions may result from unwanted or excessive scar tissue and occur in various body regions including pelvic, abdominal, spinal, tendon, ophthalmic, urinary, thoracic and cardiovascular and are formed when normal tissue bonds to the surfaces of internal organs which have been traumatized or damaged during surgery. Such adhesions may join organs or other body tissues that normally are separate. Treating adhesions may necessitate additional surgery with additional costs, danger and/or discomfort to the patient.
Numerous procedures and materials have been proposed to minimize or eliminate post-surgical adhesions. Such procedures include introducing barrier materials such as metals, polymers, and natural materials over the target site. A woven material of regenerated cellulose is currently marketed for this purpose by Johnson & Johnson under the trademark Interceed�. This product, however, is not attached to tissue and remains unfixed in vivo. Other polymeric materials that have been tried for this purpose include nylon, cellophane, PTFE, polyethylene, siloxane, elastomers and polylactic acid copolymer films. Many of these materials are not biodegradable and therefore, remain in the body with unpredictable and potentially undesirable consequences.
For these reasons, it would be desirable to provide improved methods, compositions, and apparatus for inhibiting the formation of tissue adhesions following surgery and other trauma. It would be particularly desirable to provide anti-adhesion methods and compositions where a barrier layer can be formed and immobilized between tissues which are at risk of adhesion. The methods should be convenient to perform, be amenable to both open surgical and minimally invasive procedures, provide for firm anchoring of the anti-adhesion barrier at the target location of interest, and preferably utilize materials which are both biocompatible and resorbed by the body over time.
2. Description of the Background Art
WO 93/17669 describes particular hydrogel materials that may be applied to tissue, cross-linked by exposure to UV, and relied on for inhibiting tissue adhesion. U.S. patents relating to materials and methods for inhibiting tissue adhesion include U.S. Pat. Nos. 5,422,376; 5,410,016; 5,380,536; 5,366,735; 5,364,622; 5,365,883; 5,321,113; 5,266,326; 5,264,540; 5,194,473; 5,156,839; 5,135,751; 5,134,299; 5,126,141; 5,068,225; 5,017,229; 4,937,270; 4,937,254; 4,911,926; 4,889,722; 4,674,488; and 4,603,695. Published PCT applications relating to materials and methods for inhibiting tissue adhesion include WO 95/15747; WO 95/15343; WO 95/09883; WO 94/24962; WO 94/21324; WO 94/08635; WO 94/02517; WO 93/16687; WO 93/13137; WO 92/22312; and WO 92/21354. Published European applications relating to materials and methods for inhibiting tissue adhesion include 669 138; 645 150; 610 731; 608 921; 608 139; 426 368; 416 250; and 372 969. Other patents relating to applying energy to fusible materials to wound treatment include U.S. Pat. No. 5,071,417; U.S. Pat. Nos. 5,156,613; and 5,209,776. Copending related applications assigned to the assignee of the present application include U.S. Ser. Nos. 08/303,336; 08/461,227; 08/461,228 now U.S. Pat. No. 5,669,934; Ser. No. 08/481,712 now U.S. Pat. No. 5,690,675; and Ser. No. 60/011,898, the full disclosures of which are incorporated herein by reference.
The present invention provides improved methods, compositions, and apparatus for inhibiting the formation of adhesions between adjacent tissue surfaces. The risk of tissue adhesions typically arises following surgery on tissue surfaces which lie adjacent to other tissue surfaces, organs, or other body structures, where the natural healing process can cause unwanted tissue ingrowth between the healing tissue surface and the adjacent tissue surface. The situation can be exacerbated if two or more closely adjacent tissue surfaces are subjected to surgery or other trauma simultaneously.
According to the methods of the present invention, the formation of such tissue adhesions is inhibited by exposing a target region on at least one of the tissue surfaces and positioning a preformed layer of a matrix material over such target region. Energy is then applied to the matrix material in an amount sufficient to immobilize the matrix material over the target region. The adjacent tissue surfaces then reassume their natural juxtaposition, and the immobilized layer of matrix material inhibits adhesions therebetween.
The matrix material comprises a biologic substance or a biocompatible synthetic substance which will fuse or bond to underlying tissue upon application of energy from a suitable source, as described in more detail hereinafter. Preferably, although not essentially, the fusible material will be bioabsorbable so that it is resorbed over time, typically being resorbed within three months, preferably within one month, and often in 15 days or less. The matrix material need remain only until the tissue surfaces have healed sufficiently to resist adherence. Preferred is the use of biological materials, such as proteins and protein-containing mixtures, which are bioabsorbable and will bond to tissue proteins (e.g. covalently, non-covalently, physically, and combinations thereof) upon application of suitable activating energy. Exemplary proteins include collagen, gelatin, elastin, fibrinogen, fibrin, albumins, keratins, laminins, hemoglobins, and composites and mixtures thereof. Other biological materials include polysaccharides, such as glycosaminoglycans, starch derivatives, cellulose derivatives, agarose, alginate, and the like. In addition to biological materials, non-biological polymers may also find use, such as acrylates, polyvinyl resins, polylactate-glycolides, polycaprolactones, polyoxyethylenes, and the like. Each of these materials may be utilized alone, but will more frequently be employed together with a carrier substance, plasticizer, cross-linking agent, or the like. Exemplary matrix materials include collagen and gelatin combined with a plasticizer, such as poly(alcohols), e.g. glycerol or a polyethyleneglycol.
The matrix material will be applied to the target region as a preformed solid phase. By "solid phase," it is meant that the fusible material is preformed as a sheet, layer, film, strip, patch, mesh, or the like and placed over the wound region. Usually, the solid phase will be relatively dry, typically having a moisture content below 25% by weight, more usually below 15% by weight. Such dry materials are particularly convenient to store and manipulate, as described further below. The fusible material will be in the form of a solid or gel layer after energy has been applied according to the method of the present invention. That is, solid sheets, layers, films, strips, patches, and the like, may remain as a solid (although the dimensions may alter slightly as the material is softened and fused or tacked to the underlying tissue) or may be converted into gels as they absorb moisture from the tissue.
Optionally, the solid phase forms of the fusible material, such as sheets, layers, films, strips, and patches, may be reinforced with other fusible or non-fusible materials to reduce their fragility during the initial handling and placement. Usually, the reinforcement materials will also be bioabsorbable so that the reinforcement material will also be resorbed over time although perhaps at a different rate.
The methods of the present invention can rely on the application of energy from a wide variety of sources, including electromagnetic energy, particularly electrical energy, e.g. radiofrequency (RF) energy and microwave energy, infrared (heat) energy, and ultraviolet energy; optical energy, e.g. laser; mechanical energy, e.g. ultrasonic; and the like. Preferred is the use of RF energy which can be provided by conventional electrosurgical power supplies operating at frequencies typically in the range of 200 kHz to 1.2. MHz. Particularly preferred is the use of RF energy applicators which provide a uniform, dispersed energy flux over a defined area, such as inert gas beam RF energy sources, more particularly argon beam RF energy sources. Standard electrocautery devices could also find use.
The energy is applied in a pattern and manner suitable to immobilize the matrix material over the target region so that the material remains in place while the tissue surface heals. In the case of preformed films, sheets, and the like, it is necessary only to selectively apply energy to local areas (e.g. spots, lines, etc.) on the matrix material surface in order to "tack" the material to the underlying tissue. That is, in the region where energy has been applied, the matrix material will bond or otherwise fuse to the underlying tissue. In other regions, however, the matrix material will not be bound directly to the tissue, but will remain immobilized as a result of those areas where the film or sheet of material is bound. For example, the energy may be applied at least about the periphery of the preformed film or sheet in order to attach the edges of the sheet to tissue. Additional locations within the periphery may also be tacked by applying spots or other small areas of energy to the material. It will also be possible to apply the energy uniformly to a film or sheet of matrix material, thus resulting in substantially uniform bonding of the material to underlying tissue. Generally, however, it is preferred to only selectively bond or tack the material to the tissue. Surprisingly, it has been found that adhesion inhibition is superior when the solid matrix material has been "tacked" about the periphery and/or at spaced-apart interior locations than when it is fused uniformly over the entire surface.
FIG. 1 is a schematic illustration of a pair of opposed tissue surfaces where one of the surfaces has a surgical lesion at risk of tissue adhesion.
FIG. 2 illustrates a first protocol according to the method of the present invention for inhibiting tissue adhesion on the surgical lesion of FIG. 1.
FIG. 3 illustrates a second protocol according to the method of the present invention for inhibiting tissue adhesion on the surgical lesion of FIG. 1.
FIG. 4 illustrates the tissue surfaces of FIG. 1 after they have been treated by any of the protocols and released to reassume their natural juxtaposition.
FIG. 5 illustrates the dimensions of test films used to measure tear force in the Experimental section below.
Methods, compositions, and devices according to the present invention may be used for inhibiting the formation of tissue adhesions on or to any tissue subject to or at risk of adhering to an adjacent tissue surface. The present invention is particularly useful for inhibiting such tissue adhesions on tissue structures and organs, such as muscle, skin, epithelial tissue, connective or supporting tissue, nerve tissue ophthalmic and other sense organ tissue, vascular and cardiac tissues, gastrointestinal organs and tissue, pleura and other pulmonary tissue, kidney, endocrine glands, male and female reproductive organs, adipose tissue, liver, pancreas, lymph, cartilage, bone, oral tissue, mucosal tissue and the like. The methods will be particularly useful for treating surgical sites in a target region, where the surgical site may have been sutured, stapled, or otherwise closed prior to permitting the tissue surface to engage an adjacent tissue surface. The present invention provides for barriers formed from matrix materials, usually biodegradable matrix materials, between such tissue surfaces to inhibit or prevent the occurrence of tissue adhesions. As used hereinafter and in the claims, the terms "inhibit", "inhibiting", and "inhibition" will denote both total inhibition (i.e. prevention) and partial inhibition of adhesion.
The matrix materials may be any natural, modified natural, or synthetic substance which has the ability to be applied over the target region in a solid or non-solid state, and thereafter to be fused to the underlying tissue upon the application of energy from a suitable energy source. Thus, the fusible material will be able to create and/or maintain a solid, continuous film over (and sometimes penetrating into) the target region to form a barrier which inhibits or prevents the formation of adhesions between the target region and a corresponding region in an opposed tissue surface. Such fusible matrix materials should also be biocompatible (e.g., should be non-immunogenic and non-inflammatory), and usually (but not necessarily) will be bioabsorbable overtime (e.g., being partially or completely resorbed into the underlying tissue over a period from 3 days to six months).
Generally, the use of natural biological polymers, and in particular biological proteins, as the matrix material is preferred. Suitable proteins include collagen, gelatin fibrin, fibrinogen, elastin, albumins (including human serum albumin (HSA), bovine serum albumin (BSA), and ovalbumin), hemoglobins, combinations thereof, and the like, and mixtures and derivatives thereof. Particularly preferred is the use of collagen and modified collagens, such as gelatin (which is a protein-containing material obtained by hydrolysis of collagen in a well known manner), as described in application Ser. No. 08/303,336, filed on Sep. 9, 1994, the full disclosure of which is incorporated herein by reference. The fusible material will usually be applied to the target region as a solid layer, e.g., in the form of a film, sheet, patch, strip, mesh, or the like. Use of a mesh allows tissue to form a coagulum within the interstices of the mesh as energy is applied, as described in application Ser. No. 08/303,336, the disclosure of which is incorporated herein by reference.
The matrix material may alternatively comprise a polysaccharide component including one, two, or more individual polysaccharides. Exemplary polysaccharides include glycosaminoglycans such as hyaluronic acid, chondroitin sulfate, chitin, and chitosan; starch derivatives such as starch/hydroxyethyl starch; cellulose derivatives such as hydroxyethyl-cellulose, hydroxy propyl-methyl-cellulose, and carboxy-methyl-cellulose; agarose, and alginate.
In addition to the biological polymers described above, the matrix material may comprise one or more non-biologic polymers, usually in the form of a polymeric synthetic resin having a molecular weight above 10 kD, usually in the range from 25 kD to 500 kD. Exemplary non-biologic polymers include acrylates and acrylic resins such as polyacrylic acid, polyhydroxyethyl-methacrylates, and polyacrylamides; polyvinyl resins, such as polyvinyl alcohol (PVA) and polyvinylpyrrolidone; poly-organic acids and lactanes such as polylactate-glycolides and polycaprolactones; polyethylene oxides; and polypropylene oxides.
The polysaccharide, and non-biologic polymer, and combinations thereof, may comprise substantially all of the matrix material, or may comprise only a portion thereof. In the latter case, additional component(s) may be included, such as carrier substances, reinforcing materials, (e.g., reinforcing meshes, fibers, filaments, braids, and the like), and plasticizers, as described below.
The fusible matrix material will be a preformed solid, e.g., a film, sheet, patch, strip, mesh, or the like, and may optionally be reinforced with filaments, braids, meshes, and other woven and non-woven reinforcement materials. Preferably, the reinforcement materials will be bioabsorbable so that they will be resorbed together with the fusible matrix material. The solid phase forms of the fusible material may be formed by a variety of methods as described in copending application Ser. No. 08/303,336, the full disclosure of which has previously been incorporated herein by reference. Reinforcement materials can be added by various known techniques, such as impregnation, dipping, casting, co-extrusion, and the like.
In the preferred solid layer form, the fusible matrix material will initially be a relatively thin layer which can be cut or trimmed into a desired shape prior to application to the target region. The material layers will typically have a thickness in the range from 0.01 mm to 2 mm preferably from 0.04 mm to 0.5 mm. After application of the fusion energy, the fusible matrix material will be in the form of a continuous solid film or gel over the target region. That is, the layer of material may remain as a solid film, although the film will become bound to the underlying tissue and may alter in shape to some degree. Alternatively, the initial dry solid phase may be converted into a gel or gelatinous phase upon the application of energy and absorption of moisture from the underlying tissue. In the case of a fusible matrix material which is applied in the form of a mesh, the application of energy will usually form a coagulum of tissue within the interstices of the mesh, resulting in a solid or gelatinous, continuous film comprising both the fusible matrix material and the tissue coagulum after the energy has been applied.
In addition to the substances described above, the fusible matrix material of the present invention may further include dyes, pigments, and the like, which affect the energy absorption of the material in some desired manner. For example, particular dyes may be added to enhance absorption of energy from the selected energy source e.g., laser light or other optical energy. Additionally, dyes and pigments may be added simply to improve visualization of the material during use and/or permit materials having different characteristics to be distinguished from each other. Other substances and additives may be included with the fusible material for other purposes, as generally described in Parent application Ser. No. 08/303,336, filed on Sep. 9, 1994, the full disclosure of which has previously been incorporated herein by reference.
Protein and synthetic polymer matrix materials may further include glycosaminoglycans, such as hyaluronic acid, dermatan sulfate, chondroitin sulfate, and heparin. Use of the glycosaminoglycans may be desirable since such materials, which are anti-thrombotics, can further reduce adhesion to adjacent tissues and organs after the final solid or gelatinous layer has been formed by the application of energy.
The solid forms of the matrix material will preferably include a plasticizer to impart flexibility and toughness to the resulting film, sheet, or other structure. A suitable plasticizer will be biocompatible and preferably be resorbable so that they are resorbed together with the protein, polysaccharide, or synthetic polymeric component of the matrix material. Exemplary plasticizers include poly(alcohols), particularly polyalkylene alcohols and glycols, such as polyethylene glycol; polypropyleneglycol, sorbitol, and glycerol; and the like. Particularly preferred is polyethyleneglycol (PEG) having a molecular weight in the range from 200 to 3500, more preferably from 200 to 600. The placticizer, such as PEG, may be added to an aqueous solution or suspension of the protein or other matrix material to at least about 5-10%. The plasticizer may be added in the presence or absence of a crosslinker or both. The composition may also contain a viscosity enhancer such as a biocompatible polymer or sugar, such as maltose, mannitol, or PEG.
The solid forms of the fusible matrix material will typically be provided as sheets, strips, films, or patches having a thickness sufficient to provide mechanical integrity both before and after application to the target region. For most of the materials described above, and in particular for the collagen and gelatin materials, a thickness in the range from about 0.01 mm to 2 mm, with a preferred thickness from 0.04 mm to 0.5 mm is suitable. Most preferably, the thickness for the collagen and gelatin materials will be in the range from 0.04 mm to 0.1 mm. Fusible materials having thicknesses generally greater than the broad range are less suitable since they have poor energy absorption characteristics and display increasing stiffness. The peripheral dimensions of the continuous, solid sheets of fusible material are not critical. The sheets will typically be cut or trimmed to have a desired peripheral shape prior to use in the methods in the present invention.
The method of the present invention will utilize energy of a type and in an amount sufficient to fuse the fusible matrix material to underlying tissue. Suitable energy sources include electromagnetic energy, particularly electrical energy, e.g. radiofrequency (RF) energy and microwave energy, infrared (heat) energy, and ultraviolet energy; optical energy, e.g. laser; mechanical energy, e.g. ultrasonic; and the like. Preferred are the use of RF energy sources, such as those available as electrosurgical power supplies from companies such as Valleylab, Boulder, Colo., and Birtcher Medical Systems, Irvine, Calif., employing conventional RF-applying probes. Particularly preferred are radio frequency energy sources which provide for a dispersed or distributed current flow from a hand-held probe to the tissue. One such radio frequency energy source referred to as an inert gas beam coagulator which relies on flow of an inert ionizable gas, such as argon, for conducting current from the probe to the tissue.
Energy from the energy source will typically be manually directed to the fusible material overlying the tissue using a probe connected to an external power supply. The treating physician will manually direct the probe to apply energy over the surface of the fusible material and will visually confirm that fusion has been achieved. The probe may use conventional electrosurgical power supplies having an energy output from 2 W to 100 W, preferably from 20 W to 60 W. The fusible material will typically be exposed to the energy for a total time from about 5 seconds to 120 seconds, usually from 10 seconds to 40 seconds, for material having an area from 1 cm2 to 10 cm2. The precise timing will depend on the physician's visual assessment that fusion of the material to the underlying tissue has been achieved.
Referring now to FIGS. 1-5, exemplary methods according to the present invention will be described. Target regions which may be treated according to the method of the present invention will typically comprise a surgical interventional site S, such as a region which has been sutured, stapled, or otherwise surgically corrected, present in a first tissue surface T1 (FIG. 1). The tissue surface T1 may be in any of the tissues or organs set forth above, and will be opposed by a second tissue surface T2 which is retracted by conventional means, e.g., using surgical forceps F to expose the target region surrounding the interventional site S. It will be appreciated that the anti-adhesion procedures of the present invention will typically be performed immediately following the surgical intervention which results in the site S. The surgical procedures may be performed as part of conventional open surgical procedures, i.e., where an incision is made in the patient which is sufficiently large to permit direct line-of-site visualization and manipulation of instruments therethrough. The methods of the present invention will also be useful for performing minimally invasive surgical procedures, such as laparoscopic, thoracoscopic, endoscopic, arthroscopic, and similar procedures which are performed through percutaneous penetrations and while the target region is visualized under a viewing scope. The viewing scope will usually be a fiberoptic lens connected to a video display in a conventional manner, but can also be a surgical microscope, a magnifying glass, or a simple open cannula that provides direct visual observation of the target site. In the latter case, the matrix materials and energy-applying devices will be introduced through the percutaneous penetrations and manipulated under visualization through the viewing scope.
After the surgical site S is exposed, as illustrated in FIG. 1, the matrix material will be applied at a location so that it will eventually be positioned between the surgical site S and tissue on the adjacent tissue surface T2. Usually, the material will be applied directly over the surgical site S, as illustrated in FIG. 2. In FIG. 2, a preformed film of matrix material M is placed over the surgical site S and energy is applied to immobilize the matrix material thereon. The energy applicator A may be any suitable device for providing any of the energy sources described above, usually being a laser, radiofrequency energy source, or the like. Preferred is the use of an inert gas beam coagulator, as illustrated in FIG. 2.
The energy may be applied to the matrix material M either in a continuous pattern so that the entire surface of the matrix material is exposed to energy, resulting in generally uniform bonding of the matrix material to the underlying tissue surface. Alternatively, the energy may be limited to smaller regions of the matrix material, such as about the periphery of the matrix material or at limited locations, i.e., spots within the matrix material so that the layer of matrix material is "tacked" in place. When using preformed film or sheets of matrix material, it is not necessary that the entire film or sheet be adhered to the underlying tissue. It is only necessary that sufficient bonding be achieved to assure that the material is immobilized and remains in place after the adjacent tissue surfaces T1 and T2 are allowed to resume their natural juxtaposition.
It is not necessary that the matrix material M be placed directly over the surgical site S. As illustrated in FIG. 3, the matrix material M can be placed on the adjacent tissue surface T2 and fused thereto using the energy applicator A. By properly locating the matrix material M, the matrix material will be properly placed to provide the desired anti-adhesion barrier when the tissue surfaces T1 and T2 are permitted to resume their natural orientation.
In all cases, the matrix material which is in place after the tissue is allowed to come back into contact, as illustrated in FIG. 4, will remain in place for a time sufficient to inhibit adhesion of the tissue surface T2 with the surgical site S which is undergoing natural healing processes. Typically, the barrier will remain in place for at least about 3 days to a week, and often for much longer periods. It is generally desirable, however, that the matrix material eventually be resorbed so that the opportunity for immunogenic and other reactions is reduced.
The following examples are offered by way of illustration, not by way of limitation.
Materials and Methods for Collagen Patch Production and Methods for UV Crosslinking
Collagen film materials were produced according to the following methods.
Formulations A, B & C: 26 grams of gelatin (280 bloom, Hormel Foods, Austin, Minn.) and 14 grams of PEG 400 MW (Union Carbide, Danbury, Conn.) were added with 1 L water for irrigation (WFI; deionized, depyrolyzed, and γ-ray sterilized) to a 2 liter reaction vessel. The solution was stirred and heated to 50� C. for 30 minutes. The solution was then cooled to 35� C., and aliquots of 13 mL were cast into 100�15 mm sterile square polystyrene petri dishes. The solution was evaporated at approximately 20� C. and 50% relative humidity (RH) to form films. Films were split into three groups: the first was cross-linked with 9999 mJ/cm2 (Formulation A), the second with 5000 mJ/cm2 (Formulation B), and the third with 18000 mJ/cm2 (Formulation C). Cross-linking was performed with a SPECTROLINKER XL1500 UV (Spectronics Corp., Westbury, N.Y.) crosslinker equipped with 254 nm low pressure mercury bulbs.
Formulation D: 57.6 grams of gelatin as above and 14.4 grams of PEG 400 MW were added with 1.8 liter WFI to a 2 liter reaction vessel. The solution was stirred and heated to 50� C. for 20 minutes. The solution was then cooled to 35� C., and aliquots of 13 mL were cast into 100�15 mm sterile square polystyrene petri dishes. The solution was evaporated at approximately 20� C. and 50% RH to form films. The films were cross-linked with 9999 mJ/cm2 in a SPECTROLINKER XL1500 UV crosslinker equipped with 254 nm low pressure mercury bulbs.
Formulation E: 40 grams of gelatin as above were added with 1 liter WFI to a 2 liter reaction vessel. The solution was stirred and heated to 50� C. for 30 minutes. The solution was then cooled to 35� C., and aliquots of 13 mL were cast into 100�15 mm sterile square polystyrene petri dishes. The solution was evaporated at approximately 20� C. and 50% RH to form films. The films were cross-linked with 3000 mJ/cm2 in a SPECTROLINKER XL1500 UV crosslinker equipped with 254 nm low pressure mercury bulbs.
Formulation F: 451 g grams of collagen (Kensey Nash (Type F) Exton, Pa.) and 90 g of PEG 400 MW were added with 4500 mL WFI in a 5 liter reaction vessel. The solution was stirred and heated to 70� C. for 50 minutes. The material was then homogenized for 50 min. at 20,000 RPM in a Virtis Cyclone IQ2 (Gardner, N.Y.) fitted with a 20 mm diameter rotor-stator and a flow-through head containing slotted orifices with a 1 mm gap. The solution was filtered through a 100 micrometer polypropylene mesh and water was added to adjust the solids content to 3.8% (w/w). The solution was cooled to 35� C., and aliquots of 13 mL were cast into 100�15 mm sterile square polystyrene petri dishes. The gelled solution was dried at approximately 20� C. and 50% RH to form films with water content of 11-15% w/w. The films were cross-linked with 3500 mJ/cm2 in a SPECTROLINKER XL1500 UV crosslinker equipped with 254 nm low pressure mercury bulbs
Formulation G: 156.0 grams of collagen (Kensey Nash (type F) Exton, Pa.) was added to 18.1 g of PEG 400 MW and 1500 mL WFI in a 5 liter reaction vessel. The solution was stirred and heated to 70� C. for 50 minutes. The solution was then filtered through a 100 micrometer polypropylene mesh. After filtering, the solution was adjusted to 3.8% solids w/w and then cooled to 35� C. Aliquots of 13 mL were cast into 100�15 mm sterile square polystyrene petri dishes. The solution was dried at approximately 20� C. and 50% RH to form films. The films were cross-linked with 3500 mJ/cm2 in a SPECTROLINKER XL1500 UV crosslinker equipped with 254 nm low pressure mercury bulbs.
The formulations are summarized in Table 1 below.
TABLE 1______________________________________ Platicizer UV XlinkedFormulation Gelatin % by weight in mJ/cm2______________________________________None/Control Surgery only N/A N/AA Hormel gelatin PEG 400 5000 65% 35%B Hormel gelatin PEG 400 9999 65% 35%C Hormel gelatin PEG 400 18000 65% 35%D Hormel gelatin PEG 400 9999 80%E Hormel gelatin none 3000 100%F Kensey Nash PEG 400 3500 collagen 17% 83%G Kensey Nash PEG 400 3500 collagen 10.4% 89.6%______________________________________
Materials and Methods for Creating and Measuring Adhesions
The collagen and gelatin films prepared in Example 1 (A and D-G) were tested for their ability to prevent abdominal adhesions in a rat cecum--body wall adhesion model.
Creation of Wounds
Sprague Dawley rats (84) having weights of 240-280 grams at the time of surgery were used. This animal model is recognized as a standardized model in which a single, specific adhesion can be objectively measured (Harris (1995) Surgery; 117:663-9). The testing procedure was as follows:
The animals were anesthetized with an intramuscular injection of ketamine hydrochloride in combination with xylazine. The abdomen of each animal was clipped with electric clippers, and the skin was scrubbed with iodophor and rinsed with 70% alcohol. A 6 cm midline skin incision was made at the abdomen, and the skin retracted. A 4 cm incision was made through the abdominal wall. The abdominal wall was also retracted. A defect in the abdominal wall of each animal was created approximately 1 cm lateral to the midline incision. This defect was created by excising a 1�2 cm segment of parietal peritoneum, including a superficial layer of muscle. The cecum was then elevated and positioned so that at closure, the cecum will contact the abdominal wall defect. A 1�2 cm defect was then created on the serosal surface of the cecum. The cecum was abraded by scraping with a scalpel blade so that a homogenous surface of petechial hemorrhage was created over the abraded area. The abdominal wall defect was abraded in a similar manner. Both abraded areas (the cecum and body wall) were exposed to air for 10 minutes.
Control Animals
After exposure to air, the cecum defect and abdominal wall defect were placed in contact, and the midline incision closed with a 4-0 absorbable suture. The skin was closed with 4-0 silk suture or surgical staples.
Use of Different Patch Materials
Under sterile conditions, patch materials A and D-G were cut into 3�5 cm pieces. After air drying for ten minutes, a surgical defect (either abdominal wall or cecum) in each animal was covered with one of the previously prepared test patches. The patch was subsequently attached either at the periphery (tacked at the corners) or uniformly over the entire area of the patch by applying energy with an argon beam coagulator ABC 6400�, CONMED, Ithaca, N.Y. The patch-covered defect was placed into contact with the opposing tissue plane, the midline incision was closed with a 4-0 absorbable, and the skin was closed with 4-0 silk suture or surgical staples.
Seven days following surgery, all control and test animals were euthanized in a manner consistent with the Recommendations of the AVMA Panel on Euthanasia. Subsequently, the strength of adhesions were measured and compared between the various formulations. The results are summarized below in Table 2.
TABLE 2______________________________________ Location Method of No. of % animalsFormulation of Patch attachment Animals with adhesions______________________________________None/Control 5 80A Body Wall Tacked 5 0D Body Wall Tacked 5 40E Body Wall Tacked 5 40F Body Wall Uniform 10 40 Body Wall Tacked 14 7 Cecum Tacked 10 10G Body Wall Tacked 10 30 Body Wall Uniform 10 30 Cecum Tacked 10 10______________________________________
Materials and Methods for Various Test Methods
Nine physical characteristics of the test film formulations were measured as follows.
A Mitutoyo Thickness Gauge Model, IDC Mitutoyo Corp., Japan was used to determine the thickness of collagen/gelatin films. Using the release cable or the lifting lever, the thicknesses at each corner and at the center of the film were measured, for a total of 5 measurements on each film.
Percent Swell
The amount of saline absorbed by collagen/gelatin during a 22�1 hour incubation was determined as follows. Saline solution (0.9% w/w 5 mL) was added to each scintillation vial containing a test sample. The films were hydrated for 22�1 hours at 20�-25� C. The percent swell was calculated as follows: ##EQU1## Denaturation Temperature
The denaturation temperature of the collagen/gelatin components of the test films and collagen raw material were determined using a DSC 2910 Differential Scanning Calorimeter (DSC), TA Instruments, New Castle, Del. 1.0-3.0 mg of patch sample plus 0.9% w/w sodium chloride solution (13�0.4 μl) were added to an aluminum pan and hermetically sealed. Heating rates were 5� C./min or 10� C. min. Peak temperatures and enthalpy of melting were recorded.
The pliability of each collagen/gelatin film was determined as follows. The force required to bend the collagen/gelatin film through a defined distance was measured, and the bending modulus calculated from the equation given in the Machinery's Industrial Press, Inc., NY, 21st Edition, 1980. A film sample was placed in the clamp on a Swiss Height Gauge so that 8 mm of patch was free. The force required to bend the patch through a deflection of 2 mm was measured.
Tear Test
The force required to propagate a tear in collagen/gelatin films was calculated using a 3.8�2.5 cm rectangular piece from the test film having the shape and dimensions shown in FIG. 5. The force to tear between tabs A and B was measured using a Chatillon tester (TDC 200 test stand fitted with 250 g or 2.25N load cell, DGGS 250 g digital force gauge).
Tensile Strength and Strain at Failure
Tests were performed with a Chatillon TCD 200 fitted with a digital force gauge (Chatillon Instruments, Greensboro, N.C.), connected to an XY plotter. Film samples were typically 1�3 cm and were glued to polystyrene tabs with cyanoacrylate (Superglue). Films and tabs were hydrated for precisely 1 min. in 0.9% (w/w) sodium chloride and blotted briefly. The plastic tabs were clamped in the jaws of the tester, which assured that tensile failure occurred within the sample and not at the point of clamping. Stress was computed as force in Newtons divided by the original cross-sectional area (determined from thickness and width of test films); percent strain at failure was Δl/l0 �100 where Δl is the change in length and l0 is the original sample length.
Elasticity (%)=(amount of sample stretch�100)/10
Loss on Drying
Weight loss on drying of collagen/gelatin films, raw material collagen, slurries, and solutions were determined by placing the test samples into an oven which had been set at 120��5� C. The sample remained in the oven for at least 20 minutes after the oven had reached its set temperature. Percent loss on drying was calculated using the following formula: ##EQU2## Percent solids was calculated using the following formula: ##EQU3## Collagenase Digestion
Film samples were cut into disks 6 mm in diameter, using a steel punch. Such disks typically weighed 2-3 mg and were between 0.04 and 0.07 mm thick. The sample disks were placed in 2.0 ml of a digestion buffer (Tris-HCl, pH 7.5, 0.05M, containing 0.005M CaCl2) plus 120 μl of a Clostridial collagenase solution. The collagenase was prepared at 300 units/ml in 0.05M Tris-HCl, pH 7.5, containing 0.0005M CaCl2. Enzyme units were as given by the manufacturer, based on hydolysis of furylacryloyl-Leu-Gly-Pro-Ala. The level of enzyme was sufficient to be in excess for all film samples taken. The sample in buffer and enzyme was incubated with shaking at 37� C. until the sample disk disintegrated, which was scored as digestion time.
The results of these tests for formulations B-G are summarized in Table 3 below.
TABLE 3______________________________________ Formulation:Test Method B C D E F G______________________________________Thickness (mm) 0.054 0.053 0.054 0.053 0.046 0.049% Swell 402 293 293 285 321 510DSC Peak (�C.) 33.7 35.5 35.5 36.7 35.5 35.2Pliability (mN) 1.4 1.4 1.4 1.5 1.5 3.2Tear test (N) 0.022 0.025 0.025 0.040 0.018 0.019Tensile strength at failure 106 313 307 136 174 361(N/cm2)Strain at Failure (%) 55 54 54 58 44 97Loss on drying (%) 12.2 13.3 13.3 21.7 11.9 15.5Collagenase Digestion (min.) 10 60 60 33 42 18______________________________________
Although the foregoing invention has been described in some detail by way of illustration and example, for purposes of clarity of understanding, it will be obvious that certain changes and modifications may be practiced within the scope of the appended claims.
|Cited Patent
|Filing date
|Publication date
|Jun 29, 1984
|Aug 5, 1986
|Japan Medical Supply Co., Ltd.
|Use of molded polymeric material for preventing adhesion of vital tissues
|Mar 4, 1985
|Jun 23, 1987
|American Hospital Supply Corporation
|Method of treating bone fractures to reduce formation of fibrous adhesions
|Jun 16, 1987
|Aug 8, 1989
|Laser Surgery Software, Inc.
|Laser healing method and apparatus
|Feb 19, 1988
|Dec 26, 1989
|Ethicon, Inc.
|Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
|Nov 16, 1988
|Mar 27, 1990
|Mediventures Inc.
|Method and composition for reducing postsurgical adhesions
|Jan 26, 1988
|Jun 26, 1990
|Ethicon, Inc.
|Method for inhibiting post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug
|Sep 18, 1987
|Jun 26, 1990
|Genzyme Corporation
|Water insoluble derivatives of hyaluronic acid
|Jun 25, 1990
|May 21, 1991
|Genzyme Corporation
|Water insoluble derivatives of hyaluronic acid
|Aug 10, 1990
|Nov 26, 1991
|Mdr Group, Inc.
|Viscoelastic fluid for use in surgery and other therapies and method of using same
|Jun 15, 1990
|Dec 10, 1991
|Rare Earth Medical Lasers, Inc.
|Laser fusion of biological materials
|Aug 10, 1990
|Jun 30, 1992
|Mediventures Incorporated
|Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
|Dec 13, 1990
|Jul 28, 1992
|Johnson & Johnson Medical, Inc.
|Process for preparing a neutralized oxidized cellulose product and its method of use
|Dec 12, 1989
|Aug 4, 1992
|Mediventures Incorporated
|Composition for reducing postsurgical adhesions
|Feb 13, 1991
|Oct 20, 1992
|Interface Biomedical Laboratories Corp.
|Collagen welding rod material for use in tissue welding
|Jun 14, 1990
|Oct 20, 1992
|Mdr Group, Inc.
|Viscoelastic fluid for use in spine and general surgery and other surgery and therapies and method of using same
|May 21, 1990
|Mar 16, 1993
|Mitsui Toatsu Chemicals, Inc.
|Modified polyester composition and preparation process and use thereof
|Jul 27, 1990
|May 11, 1993
|The Trustees Of Columbia University In The City Of New York
|Tissue bonding and sealing composition and method of using the same
|Jul 20, 1992
|Nov 23, 1993
|Ethicon, Inc.
|Aromatic polyanhydrides
|Jun 30, 1992
|Nov 30, 1993
|Pfizer Hospital Products Group, Inc.
|In situ modification of alginate
|May 14, 1993
|Jun 14, 1994
|Ethicon, Inc.
|Copolymers of an aromatic anhydride and aliphatic ester
|Jul 28, 1992
|Oct 18, 1994
|Research Foundation Of State University Of N.Y.
|Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
|Oct 13, 1993
|Nov 15, 1994
|Dr. Karl Thomae Gmbh
|Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydroxyethylcellulose hydrogel
|Nov 17, 1992
|Nov 22, 1994
|Mediventures, Inc.
|Method and composition for post-surgical adhesion reduction
|Aug 5, 1991
|Jan 10, 1995
|The Board Of Regents, The University Of Texas System
|Biocompatible microcapsules
|Mar 1, 1993
|Apr 25, 1995
|Board Of Regents, The University Of Texas System
|Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
|May 11, 1994
|Jun 6, 1995
|Webb; Bradford C.
|Synthetic viscoelastic material for ophthalmic applications
|Feb 10, 1994
|Apr 2, 1996
|Bio-Vascular, Inc.
|Soft tissue stapling buttress
|Dec 7, 1989
|Jun 13, 1990
|Low molecular weight heparin, heparinoid and hexuronyl hexosaminoglycan sulfate containing adhesion prevention barrier and process
|Jul 16, 1990
|Mar 13, 1991
|The Research Foundation Of State University Of New York
|N-acylurea and O-acylisourea derivatives of hyaluronic acid
|Oct 24, 1990
|May 8, 1991
|Howmedica Inc.
|Compositions containing derivatives of chitin for preventing adhesion
|Jan 20, 1994
|Jul 27, 1994
|Ethicon Inc.
|Elastomeric medical device
|May 24, 1990
|Aug 3, 1994
|MITSUI TOATSU CHEMICALS, Inc.
|Modified polyester composition and preparation process and use thereof
|Jan 27, 1994
|Aug 17, 1994
|United States Surgical Corporation
|Post-surgical anti-adhesion device
|Sep 29, 1994
|Mar 29, 1995
|Hercules Incorporated
|Medical devices subject to triggered disintegration
|Feb 13, 1995
|Aug 30, 1995
|Research Development Foundation
|Amniotic membrane graft or wrap to prevent adhesions or bleeding of internal organs
|May 19, 1992
|Nov 26, 1992
|Genzyme Corp
|Water insoluble derivatives of polyanionic polysaccharides
|May 29, 1992
|Dec 10, 1992
|Gliatech Inc
|Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
|Jun 17, 1992
|Dec 23, 1992
|Jonas Wadstroem
|Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
|Dec 8, 1992
|Jul 8, 1993
|Process for insolubilizing n-carboxyalkyl derivatives of chitosan
|Mar 1, 1993
|Sep 2, 1993
|Univ Texas
|Gels for encapsulation of biological materials
|Mar 1, 1993
|Sep 16, 1993
|Univ Texas
|Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
|Jul 28, 1993
|Feb 3, 1994
|Anika Res Inc
|Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
|Oct 22, 1993
|Apr 28, 1994
|Materials Technology Consultan
|Biodegradable polymer implant materials
|Mar 23, 1994
|Sep 29, 1994
|Focal Inc
|Apparatus and method for local application of polymeric material to tissue
|Apr 28, 1994
|Nov 10, 1994
|Focal Inc
|Apparatus and methods for intraluminal photothermoforming
|Oct 5, 1994
|Apr 13, 1995
|Univ Texas
|Multifunctional organic polymers
|Dec 1, 1994
|Jun 8, 1995
|Marinepolymer Tech Inc
|Dec 9, 1994
|Jun 15, 1995
|Univ Texas
|Local delivery of fibrinolysis enhancing agents
|Abstract, Abstract No. 111:45215, Miyata et al. Biodegradable Antiadhesive Membrane, Jinko Zoki (1989), 18(1), 93 6.
|Abstract, Abstract No. 111:45215, Miyata et al. Biodegradable Antiadhesive Membrane, Jinko Zoki (1989), 18(1), 93-6.
|Oz et al. "Preliminary report: laser welding and fibrinogen soldering are superior to sutured cholecyctostomy closure in a canine model." SPIE 1200:55-59, 1990.
|Oz et al. Preliminary report: laser welding and fibrinogen soldering are superior to sutured cholecyctostomy closure in a canine model. SPIE 1200:55 59, 1990.
|Citing Patent
|Filing date
|Publication date
|Mar 31, 1999
|Sep 11, 2001
|Ethicon Endo-Surgery, Inc.
|Method for repairing tissue defects using an ultrasonic device
|Jan 9, 1999
|Oct 30, 2001
|Last Chance Tissue Adhesives Corporation
|High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces
|Nov 6, 1998
|Apr 16, 2002
|Neomend, Inc.
|Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
|Apr 1, 1999
|Oct 1, 2002
|Neomend, Inc.
|Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
|May 19, 2000
|Nov 12, 2002
|Genzyme Corporation
|Device for delivery of surgical materials
|Sep 1, 1999
|Feb 18, 2003
|Ntero Surgical, Inc.
|Systems and methods for reducing post-surgical complications
|Sep 20, 2000
|Nov 11, 2003
|Ntero Surgical, Inc.
|Systems and methods for reducing post-surgical complications
|Mar 1, 2000
|Dec 2, 2003
|The Uab Research Foundation
|Porous tissue scaffolding materials and uses thereof
|Apr 13, 2000
|Jun 1, 2004
|Neomend, Inc.
|Pretreatment method for enhancing tissue adhesion
|Oct 9, 2001
|Aug 10, 2004
|Tissue Adhesive Technologies, Inc.
|Light energized tissue adhesive conformal patch
|Feb 26, 2002
|Aug 10, 2004
|D. Bommi Bommannan
|System and method for reducing post-surgical complications
|Oct 9, 2001
|Aug 24, 2004
|Tissue Adhesive Technologies, Inc.
|Method for making a light energized tissue adhesive
|Mar 22, 2001
|Aug 31, 2004
|Keraplast Technologies, Ltd.
|Implantable prosthetic or tissue expanding device
|Feb 9, 2001
|Dec 14, 2004
|Neomend, Inc.
|Systems, methods, and compositions for achieving closure of vascular puncture sites
|Jul 3, 2001
|Feb 22, 2005
|The University Of Alabama
|Laser hydrolysis of polypeptides
|Oct 9, 2001
|Apr 5, 2005
|Tissue Adhesive Technologies, Inc.
|Light energized tissue adhesive
|Mar 7, 2000
|May 31, 2005
|Neomend, Inc.
|Biocompatible material composition adaptable to diverse therapeutic indications
|Oct 9, 2001
|Sep 6, 2005
|Tissue Adhesive Technologies, Inc.
|Composite tissue adhesive
|Feb 9, 2001
|Sep 27, 2005
|Neomend, Inc.
|Systems, methods, and compositions for achieving closure of vascular puncture sites
|Feb 28, 2001
|Feb 7, 2006
|Neomend, Inc.
|Systems for applying cross-linked mechanical barriers
|May 20, 2004
|Sep 12, 2006
|Mandelbaum Jon A
|Surgical method and composition utilizing submucosal tissue to prevent incisional hernias
|Feb 28, 2000
|Oct 24, 2006
|University Of Utah Research Foundation
|Elastin-based compositions
|Jun 19, 2002
|Oct 31, 2006
|Tyco Healthcare Group Lp
|Bioabsorbable adhesive compounds and compositions
|Sep 18, 2006
|Jul 10, 2007
|Tyco Healthcare Group Lp
|Bioabsorbable adhesive compounds and compositions
|Dec 2, 2004
|Jul 24, 2007
|Neomend, Inc
|Biocompatible material composition adaptable to diverse therapeutic indications
|May 8, 2002
|Oct 9, 2007
|Neomend, Inc.
|Systems, methods, and compositions for achieving closure of vascular puncture sites
|Oct 22, 2004
|Jan 15, 2008
|Neomend, Inc.
|Systems, methods, and compositions for achieving closure of vascular puncture sites
|Dec 12, 2003
|Feb 19, 2008
|Kimberly-Clark Worldwide, Inc.
|Tissue products comprising a cleansing composition
|Jul 9, 2007
|Dec 22, 2009
|Tyco Healthcare Group Lp
|Joining tissues with composition containing bioabsorbable isocyanate compound
|Dec 28, 2004
|Jan 5, 2010
|Kimberly-Clark Worldwide, Inc.
|Composition and wipe for reducing viscosity of viscoelastic bodily fluids
|Sep 21, 2009
|Apr 6, 2010
|Tyco Healthcare Group Lp
|Joining tissues with composition of bioabsorbable isocyanate and amine-substituted polyalkylene glycol
|Apr 2, 2004
|Jun 1, 2010
|Tissuemed Limited
|Tissue-adhesive formulations
|May 20, 2004
|Jul 20, 2010
|Kensey Nash Corporation
|Anti-adhesion device
|Feb 18, 2010
|Jul 20, 2010
|Tyco Healthcare Group Lp
|Joining tissue with bioabsorbable isocyanate
|Dec 6, 2006
|Dec 28, 2010
|Tyco Healthcare Group Lp
|Bioabsorbable surgical composition
|Dec 6, 2006
|Mar 22, 2011
|Tyco Healthcare Group Lp
|Carbodiimide crosslinking of functionalized polyethylene glycols
|Jan 28, 2005
|Apr 12, 2011
|Ferrosan Medical Devices A/S
|Haemostatic sprays and compositions
|Dec 23, 2002
|Apr 12, 2011
|Ferrosan Medical Devices A/S
|Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
|Dec 6, 2006
|May 24, 2011
|Tyco Healthcare Group Lp
|Biocompatible surgical compositions
|Dec 11, 2003
|Jun 7, 2011
|Ferrosan Medical Devices A/S
|Gelatine-based materials as swabs
|Dec 6, 2006
|Aug 16, 2011
|Tyco Healthcare Group Lp
|Biocompatible tissue sealants and adhesives
|Jul 7, 2005
|Sep 20, 2011
|Ferrosan Medical Devices A/S
|Haemostatic composition comprising hyaluronic acid
|Dec 21, 2007
|Oct 11, 2011
|Neomend, Inc.
|Tissue adhering compositions
|Feb 2, 2007
|Mar 13, 2012
|Tissuemed Limited
|Tissue-adhesive materials
|Jul 29, 2005
|Mar 13, 2012
|Tissuemed Limited
|Tissue-adhesive materials
|Dec 18, 2007
|Jun 26, 2012
|Ethicon, Inc.
|Methods of making composite prosthetic devices having improved bond strength
|Feb 13, 2008
|Jul 17, 2012
|Neomend, Inc.
|Systems and methods for sealing a vascular puncture
|Apr 7, 2011
|Oct 9, 2012
|Ferrosan Medical Devices A/S
|Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostasis
|Dec 6, 2006
|Oct 16, 2012
|Tyco Healthcare Group Lp
|Bioabsorbable compounds and compositions containing them
|Nov 17, 2010
|Jan 22, 2013
|Covidien Lp
|Bioabsorbable surgical composition
|Jul 19, 2010
|Jan 29, 2013
|Kensey Nash Corporation
|Anti-adhesion device
|Dec 17, 2009
|Feb 26, 2013
|Neomend, Inc.
|Tissue adhering compositions
|Jun 3, 2009
|Apr 2, 2013
|Neomend, Inc.
|Biocompatible material composition adaptable to diverse therapeutic indications
|Dec 8, 2006
|May 28, 2013
|Covidien Lp
|Biocompatible surgical compositions
|Oct 27, 2008
|Aug 6, 2013
|Covidien Lp
|Speeding cure rate of bioadhesives
|Feb 27, 2009
|Feb 4, 2014
|Ferrosan Medical Devices A/S
|Device for promotion of hemostasis and/or wound healing
|Jan 2, 2013
|Jul 29, 2014
|Covidien Lp
|Biocompatible surgical compositions
|Feb 5, 2001
|Oct 28, 2004
|David Fortune
|Device for the closure of a surgical puncture
|May 20, 2004
|Mar 3, 2005
|Mandelbaum Jon A.
|Surgical method and composition utilizing submucosal tissue to prevent incisional hernias
|Oct 22, 2004
|Apr 21, 2005
|Neomend, Inc.
|Systems, methods, and compositions for achieving closure of vascular puncture sites
|Dec 3, 2004
|Jun 9, 2005
|Mcnally-Heintzelman Karen M.
|Tissue-handling apparatus, system and method
|Dec 3, 2004
|Jun 9, 2005
|Mcnally-Heintzelman Karen M.
|Wound closure apparatus
|Dec 12, 2003
|Jun 16, 2005
|Annastacia Kistler
|Tissue products comprising a cleansing composition
|Jan 31, 2005
|Aug 4, 2005
|Southwest Ressearch Institute
|Implantable prosthetic or tissue expanding device
|Apr 30, 2004
|Nov 3, 2005
|Kimberly-Clark Worldwide, Inc.
|Pre-wipes for improving anal cleansing
|Feb 25, 2003
|Jan 19, 2006
|Tsou Paul M
|Patch material for intervertebral disc annulus defect repair
|Dec 2, 2004
|Feb 2, 2006
|Neomend, Inc.
|Biocompatible material composition adaptable to diverse therapeutic indications
|Mar 27, 2003
|Apr 13, 2006
|University Of Utah Research Foundation
|Elastin prevents occlusion of body vessels by vascular smooth muscle cells
|Apr 2, 2004
|May 18, 2006
|Fortune David H
|Tissue-adhesive formulations
|Dec 11, 2003
|Jun 1, 2006
|Hansen John E
|Gelatine-based materials as swabs
|Dec 28, 2004
|Jun 29, 2006
|Kimberly-Clark Worldwide, Inc.
|Skin cleansing system comprising an anti-adherent formulation and a cationic compound
|Dec 28, 2004
|Jun 29, 2006
|Kimberly-Clark Worldwide, Inc.
|Composition and wipe for reducing viscosity of viscoelastic bodily fluids
|Jul 7, 2005
|Jan 11, 2007
|Lene Moller
|Haemostatic composition comprising hyaluronic acid
|Sep 18, 2006
|Jan 18, 2007
|Tyco Healthcare Group Lp
|Bioabsorbable adhesive compounds and compositions
|Dec 18, 2003
|Jun 22, 2005
|Antoine Turzi
|Albumin-based bioresorbable cross-linked hydrogel
|Nov 22, 1999
|Jun 2, 2000
|Bio Silk Ltd
|Enzymatic treatment and prevention of hypertrophic skin
|Oct 27, 2000
|May 3, 2001
|Fortune David Harry
|Flexible sheets for use in therapy
|Oct 27, 2000
|May 3, 2001
|Edwardson Peter
|Medical use
|Aug 16, 2011
|Feb 23, 2012
|Mast Biosurgery Ag
|Anti-adhesion alginate barrier of variable absorbance
|U.S. Classification
|128/898, 606/215, 606/213, 602/904, 606/214
|International Classification
|Cooperative Classification
|European Classification
|Nov 8, 1996
Owner name: FUSION MEDICAL TECHNOLOGIES, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:REICH, CARY J.;WALLACE, DONALD;DAPPER, GREG;REEL/FRAME:008352/0231;SIGNING DATES FROM 19961025 TO 19961030
|Nov 16, 2001
|Fee payment
Year of fee payment: 4
|Mar 1, 2006
|Maintenance fee reminder mailed
|Aug 11, 2006
|Lapse for failure to pay maintenance fees
|Oct 10, 2006
|Expired due to failure to pay maintenance fee
Effective date: 20060811
|May 13, 2010
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAXTER HEALTHCARE CORPORATION;REEL/FRAME:024383/0257
Owner name: BAXTER HEALTHCARE S.A.,SWITZERLAND
Effective date: 20100422
Owner name: BAXTER HEALTHCARE CORPORATION,ILLINOIS
Effective date: 20020627
Free format text: MERGER;ASSIGNOR:FUSION MEDICAL TECHNOLOGIES, INC.;REEL/FRAME:024381/0522
Owner name: BAXTER INTERNATIONAL INC.,ILLINOIS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAXTER HEALTHCARE CORPORATION;REEL/FRAME:024383/0257
Effective date: 20100422


text:
03 Sep
NCAAF 03 Sep
Rick Neuheisel says Jim Harbaugh slapped his hand during the most awkward handshake ever
Harbaugh story time!
Harbaugh story time!
"Come on! Come on! Who is this really?"
So much khaki.
There's nothing like a family welcome from Michael Jordan, and that's exactly what Michigan got when Jordan announced via (…)
Bad news for Michigan football fans thinking about bringing selfie sticks to The Big House this season – the university has (…)
During his visit to the Supreme Court. Because of course he visited the Supreme Court.
Harbaugh continues to bandwagon tweet.


text:
Our new "How to Study the Bible" series starts soon! Sign up today.
4:19 Geber . . . Gilead. For Sihon see Num. 32:33; Deut. 2:24–37. Subsequent to the Israelite capture of Sihon's territory, the Israelites defeated King Og of Bashan and captured all his lands (east of the Sea of Chinneroth; see Num. 32:33; Deut. 3:1–11). Geber was therefore governor over a large district east of the Jordan.


text:
The U.S. Supreme Court today gave companies new ammunition to defeat securities fraud class actions. In Halliburton v. Erica P. John Fund, the Court held that defendants can, at the preliminary class certification stage,...more
- Basic v Levinson Class Action Fraud Fraud-on-the-Market Halliburton Halliburton v Erica P. John Fund SCOTUS Securities Litigation
On Friday, the Delaware Supreme Court adopted the business judgment rule standard of review for some controlling stockholder freeze-out mergers and potentially other interested party transactions. In Kahn, et al. v. M&F...more
- Business Judgment Rule Controlling Stockholders Freeze-Out Mergers Mergers Standard of Review
Basic v Levinson
Business Judgment Rule
Class Action
Controlling Stockholders
Freeze-Out Mergers
Halliburton v Erica P. John Fund
Securities Litigation
Standard of Review
Your first step to building a free, personalized, morning email brief covering pertinent authors and topics on JD Supra:
Sign up to create your digest using LinkedIn*
Back to Top
Copyright ©


text: Had stop there for lunch on my way to Canal Walk Shopping Centre. The outside tables have a nice view on the canal. Had a beef & cheese burger with caramelized onions and some fried sweet potatoes. The restaurant was still quite empty. The food was ok but the service was not very nice, had to ask for salt &... More


text:
The NIH Record describes Larry Wald's work developing the tools and instrumentation that are essential for scientific progress.
Video highlights the Martinos Center's role in treating epilepsy
March 31, 2014
MGH has posted a video about a young man's quest to find a cure for his epileptic seizures, a journey that took him from Albania to Boston. Dr. Steven Stufflebeam and colleagues at the Martinos Center played an important role in helping him find one.
Watch the video here.


text:
WS Absinthe 101 Flyer Download
Concise absinthe facts at your fingertips with this one-page, two-sided flyer. Please feel free to download, print and distribute to your friends, drinking acquaintances, bar manager and liquor store manager.
Covers these FAQs:
• What is absinthe?
• What is wormwood?
• What is thujone and its role in absinthe?
• How do I store my absinthe?
• Is absinthe harmful?
• Why was absinthe banned?
• Is real absinthe legal in the US?
• Why is absinthe green? Is all absinthe green?
A Classic Cocktail
Yellow Daisy Cocktail
(Serves 6)
2 glasses gin
2 glasses French vermouth
1 glass Grand Marnier
1 dash of absinthe
Shake with ice. Strain into 6 cocktail glasses.
Not only the favourite drink, but also the one made famous, if not invented, by Richard William ("Deadwood Dick") Clark, recently deceased.*
Onetime Custer scout, Pony Express rider, Deadwood Gulch stage coach guard, inspiration for all the Deadwood Dick novels of E. L. Wheeler, friends of Wild Westerners, Wild Bill Hickok, Buffalo Bill, Poker Alice Tubbs, Calamity Jane, Madame Mustache and Diamond Dick Turner of Norfolk, Nebraska. Clark is buried on Sunrise Mountain, overlooking Deadwood Gulch, South Dakota.
*Recently in 1930 -ed.
Savoy Cocktail Book, 1930


text:
Anthony Ingersend
Ellen Pompeo Calls Out Daniel Craig for His James Bond Comments: "This Dude Needs a Reality Check"
Ellen Pompeo tweeted that Daniel Craig "needs a reality check" after the Spectre actor made seemingly disparaging comments about playing James Bond on Thursday, Oct. 8 -- see what they each said!Us Weekly
- The Easy Loan SiteSponsored
Banks worried homeowners will do this
Homeowners are surprised and furious. If you owe less than $625,000 on your home, you better read this...
Ridley Scott Accused Of White-washing 'The Martian'
'The Martian' may be getting great reviews from critics, but it's now being accused of 'white-washing'. The Ridley Scott sci-fi, in which Matt Damon plays an astronaut stranded on Mars, is based on the book of the same name by American author Andy Weir. But pressure group Media Action Network for…Ben Arnold
Jack Black on Losing His Brother to AIDS: 'The Worst Thing I Can Possibly Imagine'
Jack Black opens up about the tough times in life.ETonline
Pan: Hugh Jackman Wants To Play Crocodile Hunter Steve Irwin
Hugh Jackman has revealed that he's up for playing his old friend Steve Irwin should the opportunity arise and now we really want to see a Crocodile Hunter biopic. Watch our exclusive interview with Hugh below. The star was in town to talk about his new movie 'Pan' (opening with limited previews…Tom Butler
Over 70 New Sales Companies Heading to AFM
The American Film Market has attracted more than 70 new exhibiting companies for the upcoming event, with 22 new companies from the booming Asian market. The new sellers come from 18 countries including Armenia, China, Hungary, Japan, Malta, Malaysia and Ukraine. Seven of the new sellers are from…Variety
- Kelley Blue BookSponsored
10 Most Fuel-Efficient Cars Under $25,000
The bar has been raised: check out Kelley Blue Book's Top 10 list of the most fuel-efficient cars under $25,000!
Watch Chance The Rapper & Willow Smith Interview Each Other
Chance the Rapper and Will Smith interview each other.Complex
With help from superheroes, Disney blasts past $4 billion at box office
It's thanks to Ultron and Ant-Man.Fortune
'Beasts of No Nation' Hits Cinemas and Netflix
'Beasts of No Nation,' the intense story of a child soldier in an unnamed West African country, will begin streaming on Netflix on Oct. 16, the day it opens in cinemas across the U.S.The Wall Street Journal
Aishwarya on 'Comedy Nights with Kapil' (11 photos)
Actress Aishwarya Rai Bachchan will be seen doing some daring stunts in her comeback film "Jazbaa", but the actress says it's not an action entertainer. Directed by Sanjay Gupta, "Jazbaa" has received a U/A certificate from the Central Board of Film Certification and is set to release this Friday.…Yahoo India Movies
- Palm Beach GroupSponsored
How Men of 50 Can Get An Extra $4,098 Per Month
Social Security stinks. New "702 Account" strategy allows Americans to generate up to $4,098 per month in retirement income from a unique source.
With drones in tow, Anderson debuts 'Junun' documentary
NEW YORK (AP) — Paul Thomas Anderson premiered his first documentary, "Junun," on Thursday at the New York Film Festival, unveiling a sonically rich portrait of Indian musicians recording an album with Radiohead's Johnny Greenwood.Associated Press
HBO Hires Film Producer & Executive Nora Skinner As SVP Drama Programming
HBO is bringing another executive/producer from the feature world to its drama team. Nora Skinner has joined HBO as SVP, HBO Programming, reporting to the network's head of drama, EVP HBO Programming Michael Ellenberg, who also came from a feature background. Based in HBO's Santa Monica office,…Deadline
John Boyega Has Words for His Star Wars Haters
Remember when the Star Wars: The Force Awakens trailer first came out? Everything seemed copacetic, but then there was that backward slice of the fandom that was wondering why John Boyega's Stormtrooper character, Finn, was black. (Some close-minded commenters insisted the Stormtroopers had to be…nymag.com
Selena Gomez says suffered from lupus, underwent chemotherapy
(Reuters) - Pop singer and actress Selena Gomez has revealed in an interview that she was diagnosed with the autoimmune disease lupus, which led to her canceling the end of her tour in 2013, but that the disease is now in remission. "I was diagnosed with lupus, and I've been through chemotherapy,"…Reuters
- LendingTreeSponsored
2015 Refinance Rates Take Huge Dip 2.97% APR
Rates now at 2.97% APR - $225K mortgage for $904/mo. Process is easy and quotes are free! (2.97% APR 5/1 ARM). Calculate new payment now.
Fast & Furious 8 has found its director: Straight Outta Compton's F. Gary Gray
Here's what we already knew about Fast & Furious 8. Here's something new: Fast & Furious 8 will be helmed by F. Gary Gray. Gray's involvement in the movie was all but certain days prior, when Vin Diesel posted a photo on Facebook of the two in front of a framed collage of Fast & Furious photos.The Verge
- Your all-access pass to Hollywood's biggest stars
Google Is Now Getting More Searches From Mobile Phones Than Computers
Consumers are now using mobile phones more often to search Google than desktop PCs, the company's SVP Amit Singhal revealed at Recode's Code/Mobile conference Thursday. "We are getting over 100 billion searches every month," Singhal said. Mobile overtook the desktop as the number one source of…Variety
Ari Graynor Boards Showtime's Jim Carrey Dark Comedy (Exclusive)
'I'm Dying Up Here's' ensemble cast also includes Erik Griffin, Andrew Santino and Stephen Guarino.The Hollywood Reporter
- Goodyear®Sponsored
Are You Putting Off Buying New Tires For Your Car?
Goodyear® will help you find the right tires for your vehicle. Browse our tire catalog, view offers, find a store, or use our tire selector.
John Boehner Cancels On 'Tonight Show' After Kevin McCarthy Bails On Speaker Race
Jimmy Fallon's guest lineup tonight just got nuked thanks to House Majority Leader Kevin McCarthy, who stunned Washington and TV news networks this morning by dropping his bid to succeed John Boehner as Speaker of the House. The vote to replace Boehner, aka third in line for the White House, has…Deadline
'Sicario' Star Emily Blunt to be Feted at Hamptons Film Fest
Emily Blunt will be honored with Variety's Creative Impact in Acting Award at a dinner at the Hamptons Intl. Film Festival on Oct. 11. It's a fitting location, as Blunt was named one of the fest's Rising Stars a decade ago. Speaking of Blunt's career achievements, Variety executive editor Steven…Variety
Rock & Roll Hall of Fame Announces Nominees
Janet Jackson, N.W.A, Nine Inch Nails and Deep Purple are among the nominees.ABC News Videos


text:
Video: Watch New CMT.com Webisode Series THE ROAD BETWEEN WITH LUCY HALE Episode 1
Country newcomer Lucy Hale, recently named one of CMT's NEXT WOMEN OF COUNTRY, is debuting her new webisode series, "The Road Between with Lucy Hale," today exclusively on LucyHale.CMT.com. The CMT NEXT WOMEN OF COUNTRY campaign showcases the rising generation of signed and unsigned female superstars with exclusive content including video premieres, performances and more. CMT first announced its NEXT WOMEN OF COUNTRY initiative in January 2013, and has since become a franchise dedicated to spotlighting the new generation of signed and unsigned female artists across CMT platforms and at NextWomen.CMT.com.
Watch it below:
The four-webisode series features Hale in her hometown of Memphis, Tenn., and takes the viewer behind the scenes for the making of the brand new video for her latest single, "Lie A Little Better," also revealing the story behind the song. The remaining three webisodes will premiere on Wednesday, July 30; Friday, August 1; and Wednesday, August 6, and will be available on LucyHale.CMT.com.
The exclusive world broadcast and online premiere of Hale's video for "Lie A Little Better" hits CMT and MTV Tuesday, July 29. Fans can catch the video at LucyHale.CMT.com. "Lie A Little Better" comes from Hale's debut album, "Road Between." Directed by Philip Andelman, the video for "Lie A Little Better" was shot on location in June at Nashville's Grand Ole Opry House. The video can also be found on the CMT Artists App and the network's 24/7 digital music channel, CMT Pure. The video premiere will be promoted across all of CMT's digital platforms, including CMT.com, CMT App, CMT Mobile, CMT Radio Networks and to the network's more than 11 million social media fans.
"Lie A Little Better" video teasers available here:
· http://www.cmt.com/videos/lucy-hale/1063788/lucy-hale-teaser-2.jhtml
· http://www.cmt.com/videos/lucy-hale/1063787/lucy-hale-teaser-1.jhtml
Later this month, Clear Channel will host an exclusive performance featuring Hale on the Honda Stage at the iHeartRadio Theater Los Angeles. Fans can visit iHeartRadio.com or the Honda Stage on Thursday, July 31 at 10 p.m. EDT to watch the event hosted by CMT personality Cody Alan. Hale's set will include a live performance of "Lie A Little Better" and a question-and-answer session discussing her new music.
The Memphis-born-and-raised 24-year old singer and actress first started singing along with the radio to her favorite Martina McBride, Faith Hill and Shania Twain songs. While Hale made her mark early on as an actress, best known for her role on the hit ABC Family drama "Pretty Little Liars," she is eager to share her longtime love for music with her DMG Nashville country debut album, "Road Between," released on June 3. Learn the latest about Hale on Facebook and follow her on Twitter and Instagram to find out more about her single, album and touring plans.
CMT, a unit of Viacom Inc. (NASDAQ: VIA, VIAB), is the leading television and digital authority on country music and entertainment, reaching more than 92 million homes in the U.S. CMT, CMT.com and CMT Radio offer an unparalleled mix of music, news, live concerts and series and are the top resource for country music on demand. The network's digital platforms include the 24-hour music channel, CMT Pure Country, CMT App, CMT Mobile and CMT VOD.
|Related Links
|VIDEO: The Band Perry Performs 'Live Forever' on THE ELLEN DEGENERES SHOW
October 09, 2015
|VIDEO: First Look - CMT's I LOVE KELLIE PICKLER, Premiering 11/5
October 02, 2015
|BIG & RICH Kicking off Christmas With Appearances on NBC's Today Show
December 19, 2014
|Nick Jonas, Train & More Join ABC's NEW YEAR'S ROCKIN' EVE Performance Lineup
December 18, 2014
|The Band Perry Release Video For 'Gentle On My Mind'
December 17, 2014
About Author
- Sneak Peek - GMA's Amy Robach & More on Next OPRAH: WHERE ARE THEY NOW?
- ESPN Coverage of 2015 WNBA Finals to Tip Off on ABC, 10/4
- Cowboys Visit Saints on NBC's SUNDAY NIGHT FOOTBALL
- NBC Universo to Air CONCACAF OLYMPIC QUALIFYING, 10/4
- HBO to Premiere Season 2 of THE LEFTOVERS, 10/4
- Discovery to Premiere New Season of ALASKA: THE LAST FRONTIER, 10/4
- CBS to Air Interfaith Special VETERANS JOURNEY HOME: FAITH, HOPE & WAR, 10/4
- Food Network's HALLOWEEN WARS Returns for New Spooky Season, 10/4
- New Original Series ART BREAKERS to Premiere on Ovation TV, 10/4
- Travel Channel to Premiere New Original Series 50/50, 10/4
- Showtime Announces Fall Premiere Dates for HOMELAND and THE AFFAIR
- VIDEO: Tom Hiddleston Pulls Out Robert De Niro Impression in Front of the Man Himself
- ABC Family Keeps Fetch Alive by Celebrating National Mean Girls Day, Today
- NBC Sports to Present BREEDERS' CUP CHALLENGE SERIES This Weekend
- NBC Sports to Present NASCAR SPRINT CUP Elimination Race, Today
- VIDEO: Sneak Peek- SCREAM QUEENS Get Ready for Halloween
- Fox Developing LETHAL WEAPON TV Reboot
- LISTEN TO ME MARLON Premieres 11/14 on Showtime
- VIDEO: Lena Dunham Tells ELLEN She's Not Yet Ready for Marriage!
- VIDEO: Jessica Biel Shares 'Having A Baby Makes Me Thankful'


text:
More Featured Articles
Sony posts overall profit of $780 million, mobile sales decline 16 percent
Upcoming Sony Xperia C5 Ultra and Xperia M5 shown off in leak
Sony Mobile CEO: We will never ever sell or exit from the mobile business
In the Forums
New Posts
- How can I get my camera working? 1 reply
- Why is my Sony phone trying to restart with 90 battery life left? 1 reply
- Why is my Sony E smartphone not updating my apps? 7 replies | Last reply 2 months ago
- How can I reset my camera quality after installing Lollipop on Sony C3? 0 replies | Last reply 4 months ago


text:
This content has been marked as final. Show 2 replies
1. Re: mp3 playback inside APEX?Tyson Jouglet Dec 1, 2009 12:31 PM (in response to 572312)Ralf,
If you are looking for a utility to play music on the web you can try XSPF which is an open source music player. Also you can look at Sockso which is an open source music server which uses XSPF. You would be able to get a good understanding on how to use XSPF from their documentation.
Since Oracle XE only allows 5 gigs of storage I would recommend storing your music files on the file system.
Here is a link to [how to create an XSPF xml file|http://www.xspf.org/quickstart/]
Tyson Jouglet
Edited by: Tyson Jouglet on Dec 1, 2009 10:22 AM
2. Re: mp3 playback inside APEX?jariola Dec 1, 2009 10:28 PM (in response to 572312)Hi,
Check usage of embed tag
Here is example that play video so I think same can be used to music
Br, Jari


text:
The new Yardbarker app is here! Install on your iPhone, iPad or Android device. You can also find us in Google Newsstand.
Miami Heat: Gerald Green Gives a Glimpse of His Whirlwind Scoring
When the Miami Heat signed Gerald Green to the veteran's minimum this offseason, it was with the expectation that he'd be a top player off of the bench. Green is coming off of two consecutive seasons where he had established himself as a top-flight three-point shooting threat with the Phoenix Suns. During the 2013-14 season, the swingman averaged a career-high 15.8 points on...
Via Heat Nation
23 hours ago | Discuss
Former Top Pick Shabazz Napier Speaks on Being Traded by Heat
Earlier today, Ira Winderman of The Sun Sentinel had a chance to catch up with former Miami Heat point guard, Shabazz Napier. The 2014 first round draft pick is in Miami for a 7:30 pm exhibition bout versus his former team. During a break from warmups, Napier reflected on his time with the Heat: "It was a great experience, it was a great learning experience," Napier said. "To...
Via Heat Nation
2 days ago | Discuss
Chris Bosh on Return: 'Nothing Was Taken Away From Me, I've Only Gained'
Chris Bosh made a successful return last night in the Miami Heat's preseason opener versus the Charlotte Hornets. It was his first NBA game in nearly eight months since suffering a serious blood clots ailment that ended his season and caused serious risk to his life. The veteran big man ended up scoring a team-high 14 points and made his first three shots from the field in the...
Via Heat Nation
Chris Bosh on comeback from clots: 'I've only gained'
Chris Bosh's final game of last season game Feb. 11, after which he was diagnosed with a blood clot in his lungs, keeping him out for the remainder of the year. Now though, preseason is back, and that means so is Bosh.Fortunately for everyone, the Heat's highest-paid player looked just like himself during Miami's 90-77 loss to the Hornets that kicked off their preseason. It wasn...
Via Fox Sports
Gerald Green throws down insane windmill dunk (VIDEO)
Gerald Green somehow earned just a minimum contract this summer, signing with the Heat for the lowest possible deal. Apparently, dunking just doesn't get you paid like other things can.Green has been one of the best, most exciting and certainly most dynamic dunkers in the NBA over his entire career, even showing off a Dunk Contest victory on his résumé. Now, he's got a new one...
Via Fox Sports
100 Best NBA Players- Miami Heat
(Feb. 27, 2015 – Source: Mike Ehrmann/Getty Images North America) By Christopher Kline: Senior Writer at Hoopstuff… With the season rapidly approaching, I've compiled a list of the NBA's top 100 players. The following is a breakdown of where the Miami Heat players ranked: SG Dwyane Wade (Rank: 17th) Wade is no longer in his prime, with his days of terrorizing the league...
Bosh plays in first game since being diagnosed with blood clots
MIAMI -- Chris Bosh returned to the Miami Heat lineup and scored 14 points in a 90-77 loss to the Charlotte Hornets on Sunday night in a preseason game. Bosh, who missed Miami's final 30 games last season because of blood clots in one of his lungs, played 23 minutes and grabbed seven rebounds. Brian Roberts led the Hornets with 22 points. Hornets: Roberts shot 6 of 11 from the field...
Via AP on Fox
Gerald Green throws down windmill dunk vs Hornets (Video)
Gerald Green is quickly becoming comfortable as a new member of the Miami Heat, scoring 12 points off the bench during Sunday's NBA preseason game against Charlotte. The highlight of Green's night was a fourth quarter fast break basket off a defensive steal, finishing with a windmill dunk that excited the home crowd. Video via NBA. This post appeared first on Holdout Sports. ...
Via Holdout Sports
Justise Winslow skies for soaring slam dunk against Hornets
One of the more intriguing rookies from this year's draft class has to be Miami Heat's Justise Winslow and during tonight's preseason game against Charlotte, he showed off his aerial abilities. Nearing the end of the second quarter of play, Winslow was able to come up with a steal and took flight for a one-handed slam dunk: That was very impressive, Justise! *** Winslow slam...
Via That NBA Lottery Pick
Heat to host 'Red, White & Pink' game Oct. 15
MIAMI -- The Miami HEAT announced today that it will host the HEAT "Red, White & Pink" Game presented by Baptist Health Breast Center at Miami Cancer Institute--an open scrimmage that will include the current 2015-16 roster--on Thursday, October 15th beginning at 7:00 p.m. at AmericanAirlines Arena. Doors open at 6:00 p.m. The first 5,000 HEAT fans in attendance will receive...
Via Fox Sports Florida
Helpful dolphin retrieves a Miami Heat dancer's iPhone from the bottom of the ocean (VIDEO)
Talk about a dolphin with some slick moves. This bottle-nosed Romeo showed why he's all mammal and no fish. Miami Heat dancer Teressa Cee had left her phone with a friend on a boat while diving with dolphins off the coast of the Bahamas, but he accidentally dropped the device into the ocean. Not to worry, dolphin Cacique saw the phone sink and dived to the bottom of the...
Via The Other Paper
8 days ago | Discuss
Erik Spoelstra on Dwyane Wade: I still see 'a force of nature'
Dwyane Wade's best basketball days are in the past, but Miami Heat head coach Erik Spoelstra still believes the 11-time All-Star will have a big impact on the 2015-16 team—especially when it matters the most. According to Manny Navarro of The Miami Herald, Spoelstra said he has a plan to maximize Wade's abilities while remaining cognizant of his limitations. "This is not...
Via Sportsnaut
9 days ago | Discuss
Dwyane Wade Rocks Fanny Pack, Chain, Lip Syncs 'This Is How We Do It'
South Central does it like nobody does. Dwyane Wade is living proof. The Miami Heat star had a bit of fun at media day this week when he rocked a pretty sweet fanny pack, gold chain, backwards hat and sunglasses and lip synced the theme song of 90s frat houses every, "This Is How We Do It." .@DwyaneWade shows everyone how we do it at #HEATMediaDay https://t.co/DcsZuGREsl —...
Chris Bosh says he is off blood thinners, ready for contact
Chris Bosh is no longer on blood thinners as he ramps up for the new NBA season. Bosh missed the second half of last season after being diagnosed with blood clots. He was put on blood thinners to combat the matter, and he says he is off of them now and cleared for full contact. "I am released and ready for contact," Bosh said Thursday via the South Florida Sun Sentinel...
Via Larry Brown Sports
15 days ago | Discuss
LeBron James hangs with Heat players in Miami
While it's more a case of much ado about nothing than anything else — but will likely cause pangs of regret to shoot through the hearts of Miami Heat fans, Hassan Whiteside posted a photograph on Instagram of LeBron James hanging with several Heat players, including himself and fellow former "Big Three" members Dwyane Wade and Chris Bosh, with Mario Chalmers rounding out...
Via Sportress of Blogitude
18 days ago | Discuss
Erik Spoelstra, girlfriend Nikki Sapp are engaged
Miami Heat coach Erik Spoelstra revealed on Wednesday that he recently got engaged to longtime girlfriend Nikki Sapp. Spoelstra and Sapp, a former Heat dancer, have been dating for more than two years. Spoelstra dropped the big news just before wrapping up his interview with Izzy and Ethan on 790 The Ticket. "The coolest thing I did this summer, without a doubt, I got...
Via Larry Brown Sports
22 days ago | Discuss
Heat owner proposing Miami Vice-type uniforms to fans
Maybe this is just a fun gag, but Miami Heat owner Micky Arison appears to be toying with the idea of suiting his team up in highlighter-style uniforms this upcoming season that were inspired by the show "Miami Vice." Arison used his Instagram account to put these bad boys out there for fans to peruse with the caption: "If u would like to see @Adidas produce these jerseys...
Via Sportsnaut
August 28, 2015 | Discuss
Heat News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter


text:
Project CARS newest DLC combines old beauty and new hotness
Project CARS and Bandai Namco have introduced thier newest DLC pack today for both PS4 and Xbox One featuring both... Read More
Project CARS and Bandai Namco have introduced thier newest DLC pack today for both PS4 and Xbox One featuring both... Read More
The first 17 cars that will be featured in Need for Speed were revealed by developer Ghost Games today. Unfortunately, it... Read More
During Disney's D23 conference today, the company revealed official posters for four of its upcoming sequels. The modern... Read More
The overwhelmingly popular Rocket League will soon receive its first DLC pack: Supersonic Fury. The $3.99 pack will release... Read More
To the surprise of nobody, developer Slightly Mad Studios today confirmed that the Wii U version of Project Cars has been... Read More
Evolution Studios has announced their newest pack of cars that will be coming to Driveclub on July 28th. The pack will... Read More
Slightly Mad Studios has released a patch for the PC version of the game, titled Patch 2.5, to address a number of crashes... Read More
There appears to be a problem with today's Grand Theft Auto 5 Title Update. According to players, and acknowledged by... Read More
Things on the internet can easily be taken out of context, there's no way to know the emotions fueling conversation. In... Read More
Project CARS 2 has been announced by Slightly Mad Studios. And just like the first game, it will be crowdfunded through the... Read More
The last we heard about Project Cars on the Wii U was that it would be releasing after "other formats are out."... Read More
Welcome to the latest edition of the Weekly Drop, where we give you the details on games releasing next week. Next... Read More
I was very much interested in Project CARS ever since its crowdfunding days, back before Bandai Namco took them under their... Read More
The last update to Grand Theft Auto 5 left mods disabled, but that won't hold modders down -- there's already a work... Read More
Slightly Mad Studios and Bandai Namco have been teasing Project CARS for well over a year (try something like three and... Read More
Project CARS has been in development for the past four years. It has seen a number of delays, but we finally got a release... Read More
The PC actually has a slew of great titles coming to it, whether it's new IPs like Invisible, Inc. and Not a Hero, or... Read More
Aside from the awesome games coming to PS Plus in the month of May, free for subscribers, there are also a bunch of great... Read More
It's officially The Witcher 3 month! That's great news for all of us excited to get our hands on CD Projekt... Read More
May the fourth be with you all! It's essentially the first week of May and with that we have some sweet new releases... Read More


text:
Track down the Jo Isenhart you've been in search of with our trustworthy people search tools. USA-People-Search.com has an extensive information database to help you find people based on age, past residences, relatives, aliases, and more. Find known relatives of Jo Isenhart.
You can depend on us to help you locate the right Jo Isenhart by using any data that we have in our records. Find the correct Jo using such details as previous residences and known aliases. Explore more personal information, including background checks, criminal profiles, and email addresses on USA-People-Search.com. If this Jo is not the person you are trying to trace, refer to the list of people with the last name Isenhart below. This list could include name, age, location, and relatives.
Insert more info into the search fields on the left to enhance your results. A first name, middle name, last name, city, state and/or age can be important in finding Jo Isenhart. Utilize the map to visualize their whereabouts. Once you find the Jo Isenhart you're looking for, you can then access all the public records data we have in our thorough database. Access people search results for Jo Isenhart in just a matter of seconds with our simple tools.
Home |
About Us |
All Products |
People Directory |
Articles |
Help |
Privacy |
Terms & Conditions |
Contact Us |
Link To Us |
Bookmark Us


text:
Jacket & Hat: c/o Dakine, Hand-Painted Tee: c/o Urban Grove NewYork, Leggings: c/o Hard Tail Forever, Boots: c/o Sorel, Sunnies: Warby Parker
Hey all you snow bunnies! The last days of spring skiing and boarding are upon us, so gear-up and get those buns to the slopes! April is a blast on the mountains 'cause there's a lot less bulk to layer on. A light-weight puffer, like this neon lime one from Dakine, does the trick. Poppy snow accessories and my fave hand-painted panther tee adds a pop of personality to my slope-style look.
I'm Giving away a hand-painted Panther Tee from Urban Grove New York!
Just follow the simple deets below to enter!
1. Leave a comment on this post so we know where to find ya'!
2. Follow us on twitter & RE-TWEET this post & #MondayFunday #Fashion #Giveaway on @NYCPretty & @UrbangroveNY
3. Follow NYCPretty & @UrbanGroveNewYork on Instagram and "LIKE" & COMMENT on my "Panther Tee" #giveaway pic so I know that you entered!
A winner will be chosen on Friday, April 18th!
Good luck, Lovelies!
For commercial purposes, extract supplements can be obtained from the fruit of the pericarp. Garcinia cambogia reviews is performed by a physician Chen and Oz to prove that it is an herb for weight loss, a lot of research has been done. Studies, Garcinia cambogia extract supplementation decreases the weight of the body fat accumulation, was shown to have a positive effect on prevention. We are important substances such as cholesterol (LDL), reduces the serum leptin and triglycerides. In addition, it will increase the level of serotonin and cholesterol (HDL). The study also, Garcinia cambogia extract supplements, has proven that there are no significant adverse effects on many of the eight weeks, such as its use.