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Kenneth R. Cluley
Kenneth Riebel Cluley, 83, died Wednesday, April 4, 2012.
Funeral Mass will be at 11 a.m. Monday at Our Lady Queen of Peace Catholic Church with the Rev. Michael Olson and the Rev. Sojan George concelebrating.
Rite of Committal will be in Sacred Heart Cemetery under the direction of Lunn's Colonial Funeral Home.
A rosary will be recited at 6:30 p.m. Sunday with a visitation to follow at the funeral home.
Mr. Cluley played minor league professional baseball for several teams and later was a Taystee Bread salesman.
Survivors include wife, Dianne of Wichita Falls; sons, Ken of Berryville, Texas, Eddie, Jerry, Joe, Tim and John, all of Wichita Falls; 21 grandchildren and eight great-grandchildren.
Memorials can be made to Notre Dame Catholic Schools or Faith Mission of Wichita Falls.
Online guestbook at www.lunnscolonial.com.
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The Crosley Alexandria Kitchen Island with Granite Top has a unique versatile design that lets it blend perfectly with both contemporary and traditional interiors. It has a frame that is made using manufactured wood and its top is granite for sturdiness and durability. The Alexandria Kitchen Island with Granite Top from Crosley features a spice rack, wheels for mobility, a cutting board, a spacious drawer, and a cabinet that has three interior adjustable shelves. The kitchen island is ISTA 3A certified and requires minor assembly.
Product Details
Cabinets Included
Weights & Dimensions
|Base Material: Manufactured wood
|Counter Material: Granite
|Wheels: Yes
|Product Care: Use a soft clean cloth that will not scratch the surface when dusting. Use of furniture polish is not necessary. Should you choose to use a furniture polish, test in an inconspicuous area first. Use of solvents of any kind could damage your furniture's finish. To clean, simply use a soft cloth moistened with lukewarm water, then buff with a dry soft clean cloth.
|Product Type: Kitchen Island
|Counter Finish: Black granite
|Hardware Finish (Vintage Mahogany, Classic Cherry Base Finish): Antique brass
|Hardware Finish (Black, White Base Finish): Brushed nickel
|Hardware Material: Steel
|Solid Wood Construction: No
|Style: Traditional
Drawers Included: Yes
Cabinets Included: Yes
Towel Rack: Yes
Spice Rack: Yes
|Cutting Board: No
|Stools Included: No
|Stemware Storage: No
|Finished Back: Yes
|Country of Manufacture: China
Assembly Required: Yes
|Additional Parts Required: No
|Product Warranty: 90 day limited warranty
|ISTA 3A Certified: Yes
About the ManufacturerIn 1920 Powel Crosley founded the company that pioneered radio broadcasting and mass market manufacturing around the world. Crosley had a simple idea - design a fully functioning radio, meticulously craft each unit with obsessive detail and precise accuracy, and of course add a measure of consideration for the wallet. This simple idea led Crosley Radio to become the world's largest radio manufacturer. Today the Crosley name lives on with superbly detailed replicas that truly transcend time. Re introductions of original vintage radios and turntables feature the newest technologies graced by unforgettable Crosley stylings. They're passionate about what they do, right down to the last exacting detail.
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We want you to love it. If you don't, you may return your purchase within 30 days of delivery. All you need to do is visit our Self-Service Return Center for instructions. Return credits are issued within 24 hours once the item is received and inspected. Please note that shipping charges are non-refundable. The cost of return shipping will be deducted from your refund. 30-Day Return Policy
Overall Rating
Based on 155 reviews
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Great kitchen island! James from Issaquah, WA on 09/29/2013 – Verified Buyer
It took us a while to assemble (about 8 hours), but the island arrived in perfect condition - all parts arrived undamaged, were well-packed and clearly labeled - and it looks great. The granite surface is heavy but manageable for an adult couple to lift and seems very durable. There are two minor points to watch out for during assembly - 1) when you slide the boards that make up the back of the island into place, there will be a cam screw blocking the way of one of the panels even if you followed all the earlier instructions correctly. This can be fixed by temporarily removing the post w a groove that the back panel should slide into (it's not attached at that point), putting the panel in place, then sliding the post down the length of the panel, back to its original position. 2) At the end of the assembly, we thought there was a flaw with one of the center doors because it didn't fit -- there wasn't enough vertical space to fit it. Finally, we realized that the weight of the granite top was causing the center of the kitchen island to sag very slightly, so if one person really pulls upward on the middle of the island to relieve that pressure, another should be able to snap the door into place! All in all, we have really enjoyed having more counter space in the kitchen and have found the island to be attractive and durable.
Was this helpful? Yes 18 No 0
As Beautiful as pictured. Drawer depth not listed in measurements. NanaNel from Nebraska on 11/09/2013 – Verified Buyer
Drawer depth was EXCESSIVELY less than the depth listed for the shelves. I went back to the description and found that only the height and width were listed. The measurement for drawer depth was missing. I was expecting more drawer space. But, I love the way it looks! Assembly is commitment and definitely not for the impatient or someone new to assembly. Shipping was fast and packaging was wonderfully protective so, plan on plenty of extra time to unpack items. Easily an all-afternoon project, especially, esp. if flying sole. Granite top and cabinet box were both extremely heavy and should be moved by two people. Granite top, which was exceptionally beautiful, will take 2 people (and an electric screwdriver) to remove from packing crate and place on top the cabinet. Plan on a minimum of 3 hours assembly AFTER unpacked. Parts will arrive boxed separately, and not necessarily the same day...1 box each for the counter top, the cabinet and another with the legs, if ordering something other than the rollers (rollers came automatically in cabinet pkg.) I purchased the Mahogany finish and expected the brass hardware, but it came with black nickel. Very easily replaced with what I liked better from a local hardware store, but it was another expense. Nice bonus--The doors are spring hinged into very small pivot holes on the top and bottom so, if I choose remove a door to have one of the shelves open the holes aren't noticeable. This was my 1st Wayfair purchase. I will definitely be back!
Was this helpful? Yes 10 No 0
Gorgeous cabinet Donna from Garland, TX on 06/10/2014 – Verified Buyer
I was really looking forward to getting this piece, and once it was put together, I was very happy. It's a great addition to my kitchen. Well constructed, good looking and adds a lot of space. Really pretty. This line of furniture is incredibly easy to assemble (per hubby who has had much practice). It takes time, but it's a big piece (have an extra set of hands for attaching the granite top - it's heavy). He said the instructions are very clear and very easy to follow. Everything lines up so there's no trouble there. And the one place we did have a problem (on a smaller companion island), the response was fast and courteous. Four stars instead of five because the two end door areas are really too small. Reconfiguring this island to have only two doors and one open space in the middle or three doors would vastly improve its usability. This cabinet shipped with both bun feet and casters. We used the bun feet since this is more or less a stationary piece. There is a slight odor to the piece, but it's not overwhelming, and I suspect if I could leave the doors open for a day or so it would disappear. I highly recommend this island to anyone needing to add space. Lots of colors, configurations and looks.
Was this helpful? Yes 7 No 0
Love my new island Lloye from Metamora, IL on 11/11/2014
It was a little darker wood than what is pictured...I bought the mahogany and probably should have gone with the cherry but LOVE it! Very sturdy and heavy! You will definitely need help putting it together but it wasn't too bad, all the pieces are labeled and the screws and little pieces come separated and labeled in a blister pack. Except for the wooded feet screws...I did not receive the screws for the wooden feet! They weren't included in the blister pack nor were they in the box the feet came in...and we looked through EVERYTHING! I didn't want to put the casters (wheels) on it, but those screws were included in the blister pack. Luckily my husband is extremely mechanical and had screws that would work out in his shop!! I would have been disappointed if I would have had to wait for the screws to be sent to me...especially since we would have stopped production because we wouldn't have put that granite top on only to have to turn it over when the feet screws came in.
Was this helpful? Yes 3 No 0
Exactly what I was looking for Felicia from Barnegat, NJ on 12/02/2014
I have been looking for a kitchen island cart of sorts for some time now. I have cherry cabinets and the wood on the island matches pretty well, I also like the granite. I did not have any damaged parts as some other reviews had mentioned. The only thing I will say is that I did have to air out the cabinets and drawers for a while before I put anything in them. There is an odor inside the island that does linger. Other than that, it was exactly what I expected it to be. I read a lot of reviews before purchasing and I think some people are expecting it to be the same quality of a built in island but they only way to achieve that is to have an island built in, other wise this is a great alternative. Pros: Exactly what I expected based on picture, assembly instructions clear, Nice wood finish. Cons: Odor inside cabinets and drawers, had to air it out.
Was this helpful? Yes 3 No 1


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Publications (71)305.81 Total impact
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ABSTRACT: Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is not fully understood. MMP14 is a potent pericellular collagenase that can cleave type I collagen in vitro. Here we show that tendon development is arrested in Scleraxis-Cre::Mmp14 lox/lox mice that are unable to release collagen fibrils from plasma membrane fibripositors. In contrast to its role in collagen turnover in adult tissue, MMP14 promotes embryonic tissue formation by releasing collagen fibrils from the cell surface. Notably, tendons grow to normal size and collagen fibril release from fibripositors occurs in Col-r/r mice that have a mutated collagen-I that is uncleavable by MMPs. Furthermore, fibronectin (not collagen-I) accumulates in tendons of Mmp14-null mice. We propose a model for cell-regulated collagen fibril assembly during tendon development in which MMP14 cleaves a molecular bridge tethering collagen fibrils to the plasma membrane of fibripositors.eLife Sciences 09/2015; 4. DOI:10.7554/eLife.09345 · 9.32 Impact Factor
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ABSTRACT: Embryonic growth occurs predominately by an increase in cell number; little is known about growth mechanisms later in development when fibrous tissues account for the bulk of adult vertebrate mass. We present a model for fibrous tissue growth based on 3D-electron microscopy of mouse tendon. We show that the number of collagen fibrils increases during embryonic development and then remains constant during postnatal growth. Embryonic growth was explained predominately by increases in fibril number and length. Postnatal growth arose predominately from increases in fibril length and diameter. A helical crimp structure was established in embryogenesis, and persisted postnatally. The data support a model where the shape and size of tendon is determined by the number and position of embryonic fibroblasts. The collagen fibrils that these cells synthesise provide a template for postnatal growth by structure-based matrix expansion. The model has important implications for growth of other fibrous tissues and fibrosis.eLife Sciences 05/2015; 4. DOI:10.7554/eLife.05958 · 9.32 Impact Factor
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ABSTRACT: Desmosomes and adherens junctions are intercellular adhesive structures essential for the development and integrity of vertebrate tissue, including the epidermis and heart. Their cell adhesion molecules are cadherins: type 1 cadherins in adherens junctions and desmosomal cadherins in desmosomes. A fundamental difference is that desmosomes have a highly ordered structure in their extracellular region and exhibit calcium-independent hyperadhesion, whereas adherens junctions appear to lack such ordered arrays, and their adhesion is always calcium-dependent. We present here the structure of the entire ectodomain of desmosomal cadherin desmoglein 2 (Dsg2), using a combination of small-angle X-ray scattering, electron microscopy, and solution-based biophysical techniques. This structure reveals that the ectodomain of Dsg2 is flexible even in the calcium-bound state and, on average, is shorter than the type 1 cadherin crystal structures. The Dsg2 structure has an excellent fit with the electron tomography reconstructions of human desmosomes. This fit suggests an arrangement in which desmosomal cadherins form trans interactions but are too far apart to interact in cis, in agreement with previously reported observations. Cadherin flexibility may be key to explaining the plasticity of desmosomes that maintain tissue integrity in their hyperadhesive form, but can adopt a weaker, calcium-dependent adhesion during wound healing and early development.Proceedings of the National Academy of Sciences 04/2015; 112(17). DOI:10.1073/pnas.1420508112 · 9.67 Impact Factor
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ABSTRACT: The small GTPase RhoA is a major regulator of actin reorganization during the formation of stress fibers; thus identifying molecules that regulate Rho activity is necessary for a complete understanding of the mechanisms that determine cell contractility. Here, we have identified Arhgap28 as a Rho GTPase activating protein (RhoGAP) that switches RhoA to its inactive form. We generated an Arhgap28-LacZ reporter mouse that revealed gene expression in soft tissues at E12.5, pre-bone structures of the limb at E15.5, and prominent expression restricted mostly to ribs and limb long bones at E18.5 days of development. Expression of recombinant Arhgap28-V5 in human osteosarcoma SaOS-2 cells caused a reduction in the basal level of RhoA activation and disruption of actin stress fibers. Extracellular matrix assembly studies using a 3-dimensional cell culture system showed that Arhgap28 was upregulated during Rho-dependent assembly of the ECM. Taken together, these observations led to the hypothesis that an Arhgap28 knockout mouse model would show a connective tissue phenotype, perhaps affecting bone. Arhgap28-null mice were viable and appeared normal, suggesting that there could be compensation from other RhoGAPs. Indeed, we showed that expression of Arhgap6 (a closely related RhoGAP) was upregulated in Arhgap28-null bone tissue. An upregulation in RhoA expression was also detected suggesting that Arhgap28 may be able to additionally regulate Rho signaling at a transcriptional level. Microarray analyses revealed that Col2a1, Col9a1, Matn3, and Comp that encode extracellular matrix proteins were downregulated in Arhgap28-null bone. Although mutations in these genes cause bone dysplasias no bone phenotype was detected in the Arhgap-28 null mice. Together, these data suggest that the regulation of Rho by RhoGAPs, including Arhgap28, during the assembly and development of mechanically strong tissues is complex and may involve multiple RhoGAPs.PLoS ONE 09/2014; 9(9):e107036. DOI:10.1371/journal.pone.0107036 · 3.23 Impact Factor
Article: Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane[Show abstract] [Hide abstract]
ABSTRACT: Collagen fibrils can exceed thousands of microns in length and are therefore the longest, largest, and most size-pleomorphic protein polymers in vertebrates; thus, knowing how cells transport collagen fibrils is essential for a more complete understanding of protein transport and its role in tissue morphogenesis. Here, we identified newly formed collagen fibrils being transported at the surface of embryonic tendon cells in vivo by using serial block face-scanning electron microscopy of the cell-matrix interface. Newly formed fibrils ranged in length from ∼1 to ∼30 µm. The shortest (1-10 µm) occurred in intracellular fibricarriers; the longest (∼30 µm) occurred in plasma membrane fibripositors. Fibrils and fibripositors were reduced in numbers when collagen secretion was blocked. ImmunoEM showed the absence of lysosomal-associated membrane protein 2 on fibricarriers and fibripositors and there was no effect of leupeptin on fibricarrier or fibripositor number and size, suggesting that fibricarriers and fibripositors are not part of a fibril degradation pathway. Blebbistatin decreased fibricarrier number and increased fibripositor length; thus, nonmuscle myosin II (NMII) powers the transport of these compartments. Inhibition of dynamin-dependent endocytosis with dynasore blocked fibricarrier formation and caused accumulation of fibrils in fibripositors. Data from fluid-phase HRP electron tomography showed that fibricarriers could originate at the plasma membrane. We propose that NMII-powered transport of newly formed collagen fibrils at the plasma membrane is fundamental to the development of collagen fibril-rich tissues. A NMII-dependent cell-force model is presented as the basis for the creation and dynamics of fibripositor structures.Proceedings of the National Academy of Sciences 11/2013; 110(49). DOI:10.1073/pnas.1314348110 · 9.67 Impact Factor
Article: Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization[Show abstract] [Hide abstract]
ABSTRACT: Collagen fibrils are the major tensile element in vertebrate tissues, in which they occur as ordered bundles in the extracellular matrix. Abnormal fibril assembly and organization results in scarring, fibrosis, poor wound healing and connective tissue diseases. Transmission electron microscopy (TEM) is used to assess the formation of the fibrils, predominantly by measuring fibril diameter. Here we describe a protocol for measuring fibril diameter as well as fibril volume fraction, mean fibril length, fibril cross-sectional shape and fibril 3D organization, all of which are major determinants of tissue function. Serial-section TEM (ssTEM) has been used to visualize fibril 3D organization in vivo. However, serial block face-scanning electron microscopy (SBF-SEM) has emerged as a time-efficient alternative to ssTEM. The protocol described below is suitable for preparing tissues for TEM and SBF-SEM (by 3View). We describe how to use 3View for studying collagen fibril organization in vivo and show how to find and track individual fibrils. The overall time scale is ∼8 d from isolating the tissue to having a 3D image stack.Nature Protocol 06/2013; 8(7):1433-1448. DOI:10.1038/nprot.2013.086 · 9.67 Impact Factor
Article: Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture[Show abstract] [Hide abstract]
ABSTRACT: Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency histograms of D for all age groups were modeled as two normally distributed subpopulations with smaller (D(D1)) and larger (D(D2)) mean Ds, respectively. Both D(D1) and D(D2) increase from 1.6 to 4.0 mo but decrease thereafter. From tensile tests to rupture, two strain energy densities were calculated: 1) u(E) [from initial loading until the yield stress (σ(Y))], which contributes primarily to tendon resilience, and 2) u(F) [from σ(Y) through the maximum stress (σ(U)) until rupture], which relates primarily to resistance of the tendons to rupture. As measured by the normalized strain energy densities u(E)/σ(Y) and u(F)/σ(U), both the resilience and resistance to rupture increase with increasing age and peak at 23.0 and 4.0 mo, respectively, before decreasing thereafter. Multiple regression analysis reveals that increases in u(E)/σ(Y) (resilience energy) are associated with decreases in D(D1) and increases in D(D2), whereas u(F)/σ(U) (rupture energy) is associated with increases in D(D1) alone. These findings support a model where age-related variations in tendon resilience and resistance to rupture can be directed by subtle changes in the bimodal distribution of Ds.Journal of Applied Physiology 07/2012; 113(6):878-88. DOI:10.1152/japplphysiol.00258.2012 · 3.06 Impact Factor
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ABSTRACT: The genome sequences of enterohaemorrhagic E. coli O157:H7 strains show multiple open-reading frames with collagen-like sequences that are absent from the common laboratory strain K-12. These putative collagens are included in prophages embedded in O157:H7 genomes. These prophages carry numerous genes related to strain virulence and have been shown to be inducible and capable of disseminating virulence factors by horizontal gene transfer. We have cloned two collagen-like proteins from E. coli O157:H7 into a laboratory strain and analysed the structure and conformation of the recombinant proteins and several of their constituting domains by a variety of spectroscopic, biophysical, and electron microscopy techniques. We show that these molecules exhibit many of the characteristics of vertebrate collagens, including trimer formation and the presence of a collagen triple helical domain. They also contain a C-terminal trimerization domain, and a trimeric α-helical coiled-coil domain with an unusual amino acid sequence almost completely lacking leucine, valine or isoleucine residues. Intriguingly, these molecules show high thermal stability, with the collagen domain being more stable than those of vertebrate fibrillar collagens, which are much longer and post-translationally modified. Under the electron microscope, collagen-like proteins from E. coli O157:H7 show a dumbbell shape, with two globular domains joined by a hinged stalk. This morphology is consistent with their likely role as trimeric phage side-tail proteins that participate in the attachment of phage particles to E. coli target cells, either directly or through assembly with other phage tail proteins. Thus, collagen-like proteins in enterohaemorrhagic E. coli genomes may have a direct role in the dissemination of virulence-related genes through infection of harmless strains by induced bacteriophages.PLoS ONE 06/2012; 7(6):e37872. DOI:10.1371/journal.pone.0037872 · 3.23 Impact Factor
Article: Slow Stretching That Mimics Embryonic Growth Rate Stimulates Structural and Mechanical Development of Tendon-Like Tissue In Vitro[Show abstract] [Hide abstract]
ABSTRACT: A distinctive feature of embryonic tendon development is the steady increase in collagen fibril diameter and associated improvement of tissue mechanical properties. A potential mechanical stimulus for these changes is slow stretching of the tendon during limb growth. Testing this hypothesis in vivo is complicated by the presence of other developmental processes including muscle development and innervation. Here we used a cell culture tendon-like construct to determine if slow stretch can explain the increases in fibril diameter and mechanical properties that are observed in vivo. Non-stretched constructs had an ultrastructural appearance and mechanical properties similar to those of early embryonic tendon. However, slowly stretching during 4 days in culture increased collagen fibril diameter, fibril packing volume, and mechanical stiffness, and thereby mimicked embryonic development. 3D EM showed cells with improved longitudinal alignment and elongated nuclei, which raises the hypothesis that nuclear deformation could be a novel mechanism during tendon development.Developmental Dynamics 11/2011; 240(11):2520-8. DOI:10.1002/dvdy.22760 · 2.38 Impact Factor
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ABSTRACT: Tendons are composed of longitudinally aligned collagen fibrils arranged in bundles with an undulating pattern, called crimp. The crimp structure is established during embryonic development and plays a vital role in the mechanical behaviour of tendon, acting as a shock-absorber during loading. However, the mechanism of crimp formation is unknown, partly because of the difficulties of studying tendon development in vivo. Here, we used a 3D cell culture system in which embryonic tendon fibroblasts synthesise a tendon-like construct comprised of collagen fibrils arranged in parallel bundles. Investigations using polarised light microscopy, scanning electron microscopy and fluorescence microscopy showed that tendon constructs contained a regular pattern of wavy collagen fibrils. Tensile testing indicated that this superstructure was a form of embryonic crimp producing a characteristic toe region in the stress-strain curves. Furthermore, contraction of tendon fibroblasts was the critical factor in the buckling of collagen fibrils during the formation of the crimp structure. Using these biological data, a finite element model was built that mimics the contraction of the tendon fibroblasts and monitors the response of the Extracellular matrix. The results show that the contraction of the fibroblasts is a sufficient mechanical impulse to build a planar wavy pattern. Furthermore, the value of crimp wavelength was determined by the mechanical properties of the collagen fibrils and inter-fibrillar matrix. Increasing fibril stiffness combined with constant matrix stiffness led to an increase in crimp wavelength. The data suggest a novel mechanism of crimp formation, and the finite element model indicates the minimum requirements to generate a crimp structure in embryonic tendon.Biomechanics and Modeling in Mechanobiology 07/2011; 11(3-4):449-59. DOI:10.1007/s10237-011-0324-0 · 3.15 Impact Factor
Article: Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3[Show abstract] [Hide abstract]
ABSTRACT: Tendon-like tissue generated from stem cells in vitro has the potential to replace tendons and ligaments lost through injury and disease. However, thus far, no information has been available on the mechanism of tendon formation in vitro and how to accelerate the process. We show here that human mesenchymal stem cells (MSCs) and bone marrow-derived mononuclear cells (BM-MNCs) can generate tendon-like tissue in 7days mediated by transforming growth factor (TGF) β3. MSCs cultured in fixed-length fibrin gels spontaneously synthesized narrow-diameter collagen fibrils and exhibited fibripositors (actin-rich, collagen fibril-containing plasma membrane protrusions) identical to those that occur in embryonic tendon. In contrast, BM-MNCs did not synthesize tendon-like tissue under these conditions. We performed real-time PCR analysis of MSCs and BM-MNCs. MSCs upregulated genes encoding type I collagen, TGFβ3, and Smad2 at the time of maximum contraction of the tendon-like tissue (7days). Western blot analysis showed phosphorylation of Smad2 at maximum contraction. The TGFβ inhibitor SB-431542, blocked the phosphorylation of Smad2 and stopped the formation of tendon-like tissue. Quantitative PCR showed that BM-MNCs expressed very low levels of TGFβ3 compared to MSCs. Therefore we added exogenous TGFβ3 protein to BM-MNCs in fibrin gels, which resulted in phosphorylation of Smad2, synthesis of collagen fibrils, the appearance of fibripositors at the plasma membrane, and the formation of tendon-like tissue. In conclusion, MSCs that self-generate TGFβ signaling or the addition of TGFβ3 protein to BM-MNCs in fixed-length fibrin gels spontaneously make embryonic tendon-like tissue in vitro within 7days.Matrix biology: journal of the International Society for Matrix Biology 10/2010; 29(8):668-77. DOI:10.1016/j.matbio.2010.08.005 · 5.07 Impact Factor
Article: An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery[Show abstract] [Hide abstract]
ABSTRACT: Tendons attach muscles to bone and thereby transmit tensile forces during joint movement. However, a detailed understanding of the mechanisms that establish the mechanical properties of tendon has remained elusive because of the practical difficulties of studying tissue mechanics in vivo. Here we have performed a study of tendon-like constructs made by culturing embryonic tendon cells in fixed-length fibrin gels. The constructs display mechanical properties (toe-linear-fail stress-strain curve, stiffness, ultimate tensile strength, and failure strain) as well as collagen fibril volume fraction and extracellular matrix (ECM)/cell ratio that are statistically similar to those of embryonic chick metatarsal tendons. The development of mechanical properties during time in culture was abolished when the constructs were treated separately with Triton X-100 (to solubilise membranes), cytochalasin (to disassemble the actin cytoskeleton) and blebbistatin (a small molecule inhibitor of non-muscle myosin II). Importantly, these treatments had no effect on the mechanical properties of the constructs that existed prior to treatment. Live-cell imaging and (14)C-proline metabolic labeling showed that blebbistatin inhibited the contraction of the constructs without affecting cell viability, procollagen synthesis, or conversion of procollagen to collagen. In conclusion, the mechanical properties per se of the tendon constructs are attributable to the ECM generated by the cells but the improvement of mechanical properties during time in culture was dependent on non-muscle myosin II-derived forces.Matrix biology: journal of the International Society for Matrix Biology 10/2010; 29(8):678-89. DOI:10.1016/j.matbio.2010.08.009 · 5.07 Impact Factor
Article: Growth of Collagen Fibril Seeds from Embryonic Tendon: Fractured Fibril Ends Nucleate New Tip Growth[Show abstract] [Hide abstract]
ABSTRACT: Collagen fibrils are the principal tensile element of vertebrate tissues where they occur in the extracellular matrix as spatially organised arrays. A major challenge is to understand how the mechanisms of nucleation, growth and remodelling yield fibrils of tissue-specific diameter and length. Here we have developed a seeding system whereby collagen fibrils were isolated from avian embryonic tendon and added to purified collagen solution, in order to characterise fibril surface nucleation and growth mechanisms. Fragmentation of tendon in liquid nitrogen followed by Dounce homogenisation generated fibril length fragments. Most (>94%) of the fractured ends of fibrils, which show an abrupt square profile, were found to act as nucleation sites for further growth by molecular accretion. The mechanism of this nucleation and growth process was investigated by transmission electron microscopy, atomic force microscopy and scanning transmission electron microscopy mass mapping. Typically, a single growth spur occurred on the N-terminal end of seed fibrils whilst twin spurs frequently formed on the C-terminal end before merging into a single tip projection. The surface nucleation and growth process generated a smoothly tapered tip that achieved maximum diameter when the axial extension reached approximately 13 mum. Lateral growth also occurred along the entire length of all seed fibrils that contained tip projections. The data support a model of collagen fibril growth in which the broken ends of fibrils are nucleation sites for propagation in opposite axial directions. The observed fibril growth behaviour has direct relevance to tendon matrix remodelling and repair processes that might involve rupture of collagen fibrils.Journal of Molecular Biology 04/2010; 399(1):9-16. DOI:10.1016/j.jmb.2010.04.008 · 4.33 Impact Factor
Article: The Angiogenic Inhibitor Long Pentraxin PTX3 Forms an Asymmetric Octamer with Two Binding Sites for FGF2[Show abstract] [Hide abstract]
ABSTRACT: The inflammation-associated long pentraxin PTX3 plays key roles in innate immunity, female fertility, and vascular biology (e.g. it inhibits FGF2 (fibroblast growth factor 2)-mediated angiogenesis). PTX3 is composed of multiple protomers, each composed of distinct N- and C-terminal domains; however, it is not known how these are organized or contribute to its functional properties. Here, biophysical analyses reveal that PTX3 is composed of eight identical protomers, associated through disulfide bonds, forming an elongated and asymmetric, molecule with two differently sized domains interconnected by a stalk. The N-terminal region of the protomer provides the main structural determinant underlying this quaternary organization, supporting formation of a disulfide-linked tetramer and a dimer of dimers (a non-covalent tetramer), giving rise to the asymmetry of the molecule. Furthermore, the PTX3 octamer is shown to contain two FGF2 binding sites, where it is the tetramers that act as the functional units in ligand recognition. Thus, these studies provide a unifying model of the PTX3 oligomer, explaining both its quaternary organization and how this is required for its antiangiogenic function.Journal of Biological Chemistry 04/2010; 285(23):17681-92. DOI:10.1074/jbc.M109.085639 · 4.57 Impact Factor
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ABSTRACT: The ability of tendon to withstand tensile forces is largely attributable to an extracellular matrix containing parallel collagen fibrils organized into fascicles. A major belief is that force is transmitted between collagen fibrils via interactions of molecules at the fibril surface. However, there is existing evidence (reviewed here) for persistent connections between fibrils formed by interfibrillar fusion. Furthermore, in vitro studies have shown the ability of the ends of fibrils to fuse together. In this study, we show using serial section electron microscopy of embryonic mouse-tail tendon further evidence for interfibril fusion in vivo. We showed: (1) fibrils fused via Y-shaped branches without disruption of the 67 nm D-periodicity, (2) the frequency of the branches was approximately 1:20 000 D-periods, and (3) the small angle of the Y ranged from 4 degrees to 10 degrees, indicating a structure-based mechanism of branch formation. The regular occurrence of Y-shaped branches between collagen fibrils suggests direct force transmission between fibrils. Furthermore, the formation of the Y-shaped branches by tip-to-shaft fusion would explain the paucity of fibril tips in vivo.Scandinavian Journal of Medicine and Science in Sports 05/2009; 19(4):547-52. DOI:10.1111/j.1600-0838.2009.00907.x · 2.90 Impact Factor
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ABSTRACT: Conventional preparation techniques for electron microscopy employ contrast enhancing heavy metal stains in solution to visualize isolated macromolecules. In rotary shadowing electron microscopy, the heavy metal is evaporated onto surface adsorbed molecules and macromolecular assemblies. High resolution shadowing remains a valuable method for the visualization and characterization of extracellular matrix macromolecules including fibrillar collagens, microfibrillar elements, and glycoproteins.Methods in Molecular Biology 02/2009; 522:175-81. DOI:10.1007/978-1-59745-413-1_11 · 1.29 Impact Factor
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ABSTRACT: In the scanning transmission electron microscope, the degree of electron scattering induced by biological specimens, such as ECM macromolecules, is dependent on the molecular mass. By calibrating the ratio of scattered to non-scattered electrons against a known mass standard, such as tobacco mosaic virus, it is possible to quantify absolute changes in both mass and mass distribution. These mass mapping approaches can provide important information on ECM assembly, organisation, and interactions which is not obtainable by other means.Methods in Molecular Biology 02/2009; 522:151-61. DOI:10.1007/978-1-59745-413-1_9 · 1.29 Impact Factor
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ABSTRACT: Tissue development in multicellular animals relies on the ability of cells to synthesise an extracellular matrix (ECM) containing spatially-organised fibrous assemblies, the most widespread of which is based on collagen fibrils whose length greatly exceeds that of individual cells. The importance of the correct regulation of fibril deposition is exemplified in diseases such as osteogenesis imperfecta (caused by mutations in collagen genes), fibrosis (caused by ectopic accumulation of collagen) and cardiovascular disease (which involves cells and macromolecules binding to collagen in the vessel wall). Much is known about the molecular biology of collagens but less is known about collagen fibril structure and how the fibrils are formed (fibrillogenesis). This is explained in part by the fact that the fibrils are non-crystalline, extensively cross-linked, and very large, which makes them refractory to study by conventional biochemical and high-resolution structure-determination techniques. Electron microscopy has become established as the method of choice for studying collagen fibril structure and assembly, and this article describes the electron microscope methods most often used.Methods 06/2008; 45(1):53-64. DOI:10.1016/j.ymeth.2008.01.004 · 3.65 Impact Factor
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ABSTRACT: Embryonic tendon cells (ETCs) have actin-rich fibripositors that accompany parallel bundles of collagen fibrils in the extracellular matrix. To study fibripositor function, we have developed a three-dimensional cell culture system that promotes and maintains fibripositors. We show that ETCs cultured in fixed-length fibrin gels replace the fibrin during ~6 days in culture with parallel bundles of narrow-diameter collagen fibrils that are uniaxially aligned with fibripositors, thereby generating a tendon-like construct. Fibripositors occurred simultaneously with onset of parallel collagen fibrils. Interestingly, the constructs have a tendon-like crimp. In initial experiments to study the effects of tension, we showed that cutting the constructs resulted in loss of tension, loss of fibripositors and the appearance of immature fibrils with no preferred orientation.Matrix Biology 06/2008; 27(4):371-5. DOI:10.1016/j.matbio.2007.11.006 · 5.07 Impact Factor
Article: Ageing Changes in the Tensile Properties of Tendons: Influence of Collagen Fibril Volume Fraction[Show abstract] [Hide abstract]
ABSTRACT: Connective tissues are biological composites comprising of collagen fibrils embedded in (and reinforcing) the hydrated proteoglycan-rich (PG) gel within the extracellular matrices (ECMs). Age-related changes to the mechanical properties of tissues are often associated with changes to the structure of the ECM, namely, fibril diameter. However, quantitative attempts to correlate fibril diameter to mechanical properties have yielded inconclusive evidence. Here, we described a novel approach that was based on the rule of mixtures for fiber composites to evaluate the dependence of age-related changes in tendon tensile strength (sigma) and stiffness (E) on the collagen fibril cross-sectional area fraction (rho), which is related to the fibril volume fraction. Tail tendons from C57BL6 mice from age groups 1.6-35.3 months old were stretched to failure to determine sigma and E. Parallel measurements of rho as a function of age were made using transmission electron microscopy. Mathematical models (rule of mixtures) of fibrils reinforcing a PG gel in tendons were used to investigate the influence of rho on ageing changes in sigma and E. The magnitudes of sigma, E, and rho increased rapidly from 1.6 months to 4.0 months (P-values <0.05) before reaching a constant (age independent) from 4.0 months to 29.0 months (P-values >0.05); this trend continued for E and rho (P-values >0.05) from 29.0 months to 35.3 months, but not for sigma, which decreased gradually (P-values <0.05). Linear regression analysis revealed that age-related changes in sigma and E correlated positively to rho (P-values <0.05). Collagen fibril cross-sectional area fraction rho is a significant predictor of ageing changes in sigma and E in the tail tendons of C57BL6 mice.Journal of Biomechanical Engineering 05/2008; 130(2):021011. DOI:10.1115/1.2898732 · 1.78 Impact Factor
Top Journals
The University of Manchester
Manchester, England, United Kingdom
- • Wellcome Trust Centre for Cell-Matrix Research
- • Faculty of Life Sciences
- • School of Biomedicine
University of Colorado at Boulder
Boulder, Colorado, United States
- Department of Molecular, Cellular, and Developmental Biology (MCDB)
Utrecht University
Utrecht, Utrecht, Netherlands
- Department of Cell Biology
The University of Edinburgh
Edinburgh, Scotland, United Kingdom
- Department of Clinical Biochemistry


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John Leland
Recent and archived news articles by John Leland of The New York Times.
The Fragile Patchwork of Care for New York's Oldest Old
Unpaid caregivers provide 90 percent of long-term care for the old or disabled, for those lucky enough to have someone.
September 27, 2015, Sunday
How Lee Child, Author of the Jack Reacher Novels, Spends His Sundays
The author of the thrilling series spends his Sundays eating French food, walking through the park and perusing museums.
September 27, 2015, Sunday
For a Street Photographer, 'The Weirder, the Better'
Jill Freedman photographed the hidden New York: "beggars, panhandlers, people sleeping on the street."
September 20, 2015, Sunday
When the Jewels Are Unseen in the Diamond District, but Beauty Remains
Some saw empty busts in the windows of West 47th Street shops closed for the High Holy Days, but the photographer Daniel Terna saw regal sculptures that were "more beautiful" than when they were draped with necklaces.
September 13, 2015, Sunday
Too Much in Love to Say Good Night
One steamy evening, Caleb Wiese stopped Katherine McClintic in the middle of dancing and said, "I need to talk to you."
September 4, 2015, Friday
How Heather McGhee, President of Demos, an Advocacy Group, Spends Her Sundays
Ms. McGhee spends the day enjoying the cultural side of New York City with friends, and perhaps doing a Sunday morning talk show or two.
August 30, 2015, Sunday
Superiority Burger, a Vegetarian Ode to White Castle in the East Village
Despite its name, Superiority Burger's burgers have no hamburger meat, and the cheese steak has neither cheese nor steak.
August 30, 2015, Sunday
New York Captured Between the Day and the Dark
Lynn Saville's photographs of New York during that near-dark moment when one state of being is just about to become something else.
August 30, 2015, Sunday
Pilot Killed in Crash of Home-Built Plane at Stewart International Airport
The pilot, who was from Texas, was scheduled to perform this weekend in the New York Air Show at the airport in Newburgh, N.Y.
August 29, 2015, Saturday
The '60s: In and Out of the Limelight
David Hurn's celebrity photos helped shape popular memories of the 1960s. But he was more drawn to the stuff of daily life.
August 25, 2015, Tuesday
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All Lindsay wants is a normal life. What she's got is anything but. Betrothed to the Devil by her greedy father, Lindsay was blissfully unaware there was anything unusual about her life until her twenty-first birthday, when the groom appeared before her and presented her with a black diamond wedding band. Displaying uncharacteristic patience and soft heartedness toward his young wife, Big Red (as Lindsay calls him) endures all her attempts to annul their union and forge an independent life as far away from his world as she can possibly get. In the end, all he really wants is her happiness. When the ghost of Lindsay's father visits and offers her exactly what she wants, will she still be so eager to rid herself of her husband? A paranormal romance and a Hell of a lot of fun from our Orbits sci-fi/fantasy short story line.


text: A second tornado formed and merged with the first tornado just east of Quapaw, according to the National Weather Service. The storm crossed the state line, killing 14 people in Missouri. The 175 mph winds destroyed or damaged 200 homes. "The tornado sped up everything," Reeves said, referring to a $60 million Tar Creek federally funded buyout. "Some people were not quite ready (to leave), but with the tornado they didn't have a choice." Most people, especially the elderly, thought there was a chance they could stay in Picher, he said. About 125 people remain in the town. "We will probably go through the end of the year," Reeves said. "It's hard to shut down a town."


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Date: 1948
Description: Alice in Dairyland, Margaret McGuire, and Elsie the Cow and her calf Beauregard, stand on a parade float with two men in downtown Milwaukee, while a male o...
Date: 1943-06-02
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Description: Charles J. Van Schaick and his family at the dinner table. He had three sons; Shirley, born 1885, Roy, born 1887, and Harold, born 1889. Both husband and w...
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Description: Third Wisconsin State Capitol, the second in Madison, as seen from East Washington Avenue.
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Substantial passages of Julia Loktev's turgid relationship drama "The Loneliest Planet" play like watching grass grow — or more to the point, watching three people hike across that grass in ponderously slow long shots. The story of young engaged Americans hiking across the Caucasus Mountains in the former Soviet republic of Georgia pivots on a horrible, spontaneous lapse of judgment, but then Loktev lets all the tension out of the situation.
Movie review: 'Loneliest Planet'
To be fair, what happens between Alex (Gael García Bernal) and Nica (Hani Furstenberg) is a shocking and emotionally ugly incident that points out a fatal flaw in the relationship. This is a case in which a long, boring adventure saved one member of this couple from making a terrible mistake. But the problem with "The Loneliest Planet" is that Alex and Nica are barely known before the incident, and Loktev never lets her characters truly process it beyond extended periods of pained silence.
The only character who gets fleshed out is Dato (Bidzina Gujabidze), the middle-aged local guide whom Alex and Nica hire after a night in a dank rural disco. His presence creates another layer of tension, but his fairly interesting background is only introduced well into the second hour of the film. Alex and Nica are mainly characterized by overly twee, cutesy fawning — at least until things go suddenly sour.
Continue reading this story on the...


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I sit here every day and worry about this baby. I find it so hard since I can't feel this baby and just hope that everything will be ok. I understand that if something is wrong that nature will do what it needs to do but I feel like this period of time is just so long. I am impatient by nature anyway so this doesn't help. Just wondering how you keep from going crazy right now.
How do all you Mamas not worry through the first trimester????
E & J - married 09/02/07
Liam - emergency c-section - 07/12/09 - 7lbs 12oz 21 in
Chase - unplanned vbac - 02/13/13 - 6lbs 15oz 19 3/4 in
I talk to the baby since s/he is the only one around, sounds crazy but it comforts me.
There's always a slight worry, but for me worrying will not help anything. In fact, I think it might just make it worse - added stress, etc. I'm all about positive thinking. You just have to let it go. I know, easier said than done.
Mommy to sweet and sassy A (7) and my sweet baby E (15 months)
DD Olivia 11-13-11 **Silver ( . ) ( . )**
DD Zoey 2-15-13
Married to my best friend 7/07
DD our Rainbow 7/10, ebf, cd, co-sleeping, natural birth
4 mc between 4/09 - 4/12
Not worry? Are you kidding me?! I'm a hot sloppy ball of anxiety 24/7. I try to keep busy, I try to eat right, I try to manage my household all the while being exhausted... I do what I can do to function, but in the back of my mind I have that anxiety that rears it's ugly head periodically throughout the day/week and I have a had a couple panic attacks, even.
I've been through seven m/c's, had two live births, and this is my 10th pregnancy. There is no "not worrying" for me until my baby is IN MY ARMS.
Some women are just way more laid back- and I wish so bad I was like them! I fake my way through looking laid back to the average Joe, but I really am a hot mess of anxiety. I'm not even announcing my pg until I HEAR the hb. We saw it on u/s at 9weeks, but that's not good enough for me.. I need to HEAR it. Two more weeks... two more anxiety filled weeks...
*deep breath*
Snaggletooth & MadDog, married 2/01
Clomid baby Booshka, 9/25/02
Seven 1st Tri losses
Clomid baby Buddy/Bug, 10/17/10
Suprise baby, Bubbles, 2/3/13
FTM to R (2/8/13) (c-section)
Gold ( o Y o ) (2/14)
"Not broken, just bent, we can learn to love again." -Pink
Im not from your board, but I have a 11 month old and a 2 yr old. I was a mess in the beginning of my first pregnancy. But I realized that I wanted to give my child a sense of peace growing inside me. When I would start to get worked up about something I would concentrate on imagining if my child was worried and I was comforting her. I know that is does not help anything to hear it, but from mom to mom, the little twinges and tweaks that you feel are normal. Your uterus has never been bigger than your fist-seriously look at your fist. That will grow into a watermelon. Its gotta do some stretching. Good luck too you! You are in for a wonderful journey
Benjamin & Celeste = Grace 5-13-10 Isabella 8-31-11 Alexandria 10-17-13, ^I^ 10-15-14, #4 EDD 08/20/15 Loving God's Blessings,


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21 years of experience
Accepting new patients
American Fork, UT 84003 Phone number & directions
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Dr. Peugh worked with my doctor and radiologist to determine the best solution to my repetitive cases of pancreatitis. Together they determined I needed and performed a laparoscopic gall bladder removal for me in March of 2014. During surgery he followed up with investigations and further determined I had a pancreatic mass. He referred me to the best doctor in the Nation for a follow up. His intervention and further investigation possibly saved my life. I underwent the whipple procedure and was diagnosed with stage 3 pancreatic cancer. It was caught early and surgery appears successful. I go on to chemo therapy this month. I am very impressed with his skill and his continued follow up. I would definitely go back to him again.
Dr Peugh was the best surgeon I have run across in Utah county. I would recommend him to all. He is very professional. He is very confident. He repaired my stomach with no problems. His staff is the best, caring and professional.
This guy ruined me chonic pain in my upper legs. Nerve entrapment due to hernia mesh. Do not use him. When I told him I could not pee he laughed and said little boys dont like it but you need to go to emergency room. that was the night of my surgery. nothing but complications for life due to his surgery.
Dr. Peugh did a laparoscopic hernia repair for me in January of 2013. I was very impressed with his skill in and out of the operating room. Would definitely go back to him again for general surgery and I would highly recommend him to others.
Dr. Peugh has operated on my Mother and husband.Both were up on their feet the next day and recovery time was short.He really is skilled and knowledgeable.Great well informed staff.
Rude, snide, arrogant, sarcastic. He did not answer questions, has not been reachable for follow up and Seemed almost amused I was in terrible pain. We are trying to switch providers for post op follow ups, even. Everything about my consultation and surgery day was just uncomfortable but I felt like I had no option but to just go through with it or wait it out in pain.
He could not find my hernia. He proceeded to make snide and sarcastic comments about the source of my pain. He was rude. Unhelpful. He was, in fact, insulting. I've never experienced anything like this from a doctor ever before. He finally suggested that my pain might be "X" ... but that malady only affects 90 year old women with osteoporosis. What's with that? I later went to another general surgeon who immediately detected 2 hernias, and did imaging to confirm it. He's a lousy doctor and a disgusting human being.
I had a laproscopic surgery done by Dr.Peugh.He is not the type of doctor who will spend time "getting to know you" and make small talk.I sort of liked that.Dr.Peugh asked me all the right questions,answered all my queries and seemed very professional.I was convinced right then that he would do a good job.He did a quick surgery and everything went well. At the post-op, he did surprise me by not really asking me much about how I was doing. He just checked the scars, and said everything looked fine - and that was it. It was less than 5 minutes. Anyhow, its been 3 months since my surgery, and I feel good.
I met Dr. Peugh in the emergency room with my husband. He was prompt to diagnose the problem and get it taken care of. He also made appropriate changes to make sure insurance covered the procedures. He did a great job for us.
Top notch


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MSanAgustin Photography Photographer
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My Website: http://www.facebook.com/profile.php?id=723768882My MM URL: http://www.modelmayhem.com/sarahbear850
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About MeHello, my name is Sarah. Born in Arizona and have lived man places, including London, Cali, Seattle, New york and currently Florida. I enjoy painting, playing tennis and going to the beach. I currently attend Pensacola State College and trying to obtain my A. A in art.
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Join the 'Eczema' group to help and get support from people like you.
Eczema News
Psoriasis, Cold Sores Most Stigmatized Skin Disorders: Survey
Posted 10 hours ago by Drugs.com
FRIDAY, Oct. 9, 2015 – Psoriasis and cold sores top the list of stigmatized skin conditions, a new survey indicates, but experts say much of the ill will directed at sufferers is misguided. Surveying 56 people, Boston researchers found that nearly 61 percent wrongly thought psoriasis – which produces widespread, scaly red skin lesions – looked contagious, and about nine in 10 said they would pity a person who had it. About four in 10 said herpes simplex, or cold sore, is the most bothersome skin condition. "We knew from other studies that psoriasis seemed to be more stigmatizing than other skin diseases, [and] we did this study to try to find out why," said study author Dr. Alexa Kimball, a dermatology professor at Harvard Medical School. "We suspected that the fact that it looked infectious could be part of the reason people reacted strongly to it, but we didn't expect that reaction ... Read more
Related support groups: Acne, Psoriasis, Eczema, Cold sores, Warts, Rosacea, Vitiligo, Plaque Psoriasis, Tinea Versicolor, Herpes Simplex Labialis, Minor Skin Irritation, Minor Skin Conditions
Health Tip: When a Rash Signals Trouble
Posted 15 days ago by Drugs.com
-- A skin rash often isn't a major worry, but there are warning signs that it could mean trouble. The American Academy of Dermatology says medical intervention in warranted when a rash: Spreads across the entire body. This could indicate a serious allergic reaction. Is accompanied by fever. This warrants an immediate trip to the emergency room, as it could indicate a serious infection. Spreads suddenly and very quickly. Forms blisters. Becomes painful. Read more
Related support groups: Infections, Skin Rash, Eczema, Dermatitis, Minor Skin Conditions, Minor Skin Irritation
Mouse Study Hints at Treatment for Itch-Related Ills Like Eczema
Posted 11 Jun 2015 by Drugs.com
THURSDAY, June 11, 2015 – An itch that just won't go away: Many people will suffer from eczema or some other ailment involving chronic itch during their lifetime, and a new study in mice hints at why this happens. The scientists who've spotted a gene involved in chronic itch also believe the finding could lead to new treatments. The study was co-authored by Rachel Brem, a geneticist and associate professor at the Buck Institute for Research on Aging in Novato, Calif. "An estimated 10 to 20 percent of the population will suffer from chronic itch at some point in their lifetime," Brem said in an institute news release. "In addition to eczema, chronic itch can stem from systemic conditions including kidney failure, cirrhosis and some cancers," she added. "Understanding the molecular basis of chronic itch is of significant clinical interest, and now there is a new target available to ... Read more
Tattoos May Pose Health Risks, Researchers Report
Posted 28 May 2015 by Drugs.com
THURSDAY, May 28, 2015 – Getting a tattoo may put you at risk for long-term skin problems, a new study warns. "We were rather alarmed at the high rate of reported chronic complications tied to getting a tattoo," said senior investigator Dr. Marie Leger, an assistant professor in the dermatology department at NYU Langone Medical Center in New York City. "Given the growing popularity of tattoos, physicians, public health officials and consumers need to be aware of the risks involved," Leger said in a Langone news release. For the study, researchers surveyed about 300 New York City adults, aged 18 to 69, with tattoos. Most of them had no more than five tattoos, and the arm was the most popular tattoo site (67 percent). Up to 6 percent of the study participants experienced some form of tattoo-related rash, infection, severe itching or swelling that sometimes lasted longer than four months. ... Read more
Related support groups: Infections, Bacterial Infection, Skin Infection, Eczema, Dermatitis, Bacterial Skin Infection, Contact Dermatitis, Skin and Structure Infection, Atopic Dermatitis, Secondary Cutaneous Bacterial Infections
Medical Bills Another Burden for Eczema Patients: Study
Posted 4 Mar 2015 by Drugs.com
WEDNESDAY, March 4, 2015 – Eczema isn't just a painful, chronic problem for many – it's a big drain on the pocketbook, too, a new study finds. Researchers at Northwestern University Feinberg School of Medicine in Chicago report that adults with eczema have higher health costs and more health care-related problems than those without the skin condition. That finding didn't surprise dermatologists. "When their skin is not properly managed and cared for, their disease may flare – resulting in significant itch and discomfort, leading to a lack of sleep and decreased productivity at home and at work," explained Dr. Katy Burris, a dermatologist at North Shore-LIJ Health System in Manhasset, N.Y. About 10 percent of adults and nearly 11 percent of children in the United States have eczema, but there has been little research into the costs associated with the disease, according to the study ... Read more
Related support groups: Eczema
Exposing Babies to Peanuts May Help Curb Allergy Risk
Posted 23 Feb 2015 by Drugs.com
MONDAY, Feb. 23, 2015 – Giving peanut products to infants at high risk for peanut allergy may reduce the risk of developing the allergy by 80 percent, a new study suggests. For years, the conventional wisdom was to avoid giving peanuts to infants who were at risk for developing an allergy to them. And although that recommendation was retracted in 2008, many parents continued to avoid giving peanut products to their infants, said lead researcher Dr. Gideon Lack, from the department of pediatric allergy at King's College London in England. "However, eating peanut [products] in the first year of life protects against the development of peanut allergy in a high-risk group of children," he said. "This is the exact opposite of what was recommended." Babies who have a high risk of developing a peanut allergy are those who have severe eczema and/or have an allergic reaction to eggs, Lack said. ... Read more
Related support groups: Allergies, Allergic Reactions, Eczema
Could a Dishwasher Raise Your Child's Allergy, Asthma Risk?
Posted 23 Feb 2015 by Drugs.com
MONDAY, Feb. 23, 2015 – Hand washing dishes instead of using a machine to wash dishes may reduce children's risk of developing allergic conditions, such as asthma or eczema, according to a new study. These findings are the latest to lend support to the "hygiene hypothesis." This theory suggests that early exposure to many different microbes may keep the immune system working properly. If the immune system is working well, the theory is that it won't mistakenly go after harmless substances as happens in allergies. "We have only tested an association between dishwashing methods and risk of allergy, but the findings fit well with the hygiene hypothesis. And there are studies showing that hand dishwashing very often is less effective than machine dishwashing in reducing bacterial content," said lead author Dr. Bill Hesselmar, an associate professor of allergy at Queen Silvia Children's ... Read more
Eczema Cream for Children Not a Cancer Risk, Study Finds
Posted 18 Feb 2015 by Drugs.com
WEDNESDAY, Feb. 18, 2015 – A cream used to treat the skin condition eczema in children does not appear to increase the risk of cancer, according to a study funded by the maker of the cream. Researchers looked at nearly 7,500 children in the United States who were given an average of 793 grams of pimecrolimus (Elidel) cream to treat eczema and were followed for 10 years. As of May 2014, five cases of cancer were diagnosed among the children: two leukemias, two lymphomas and one bone cancer. There were no cases of skin cancer, the researchers said. Based on the findings, "it seems unlikely" that pimecrolimus cream as used in the study to treat eczema is associated with an increased risk of cancer, lead researcher Dr. David Margolis, from the University of Pennsylvania in Philadelphia, and colleagues concluded. The study was published online Feb. 18 in the journal JAMA Dermatology and was ... Read more
Related support groups: Eczema, Dermatitis, Contact Dermatitis, Atopic Dermatitis, Elidel, Pimecrolimus
Eczema Linked to Other Health Problems
Posted 23 Jan 2015 by Drugs.com
FRIDAY, Jan. 23, 2015 – Adults with eczema – a chronic, itchy skin disease that often starts in childhood – may also have an increased risk of heart disease and stroke, according to a new study. This increased risk may be the result of bad lifestyle habits or the disease itself. "Eczema is not just skin deep," said lead researcher Dr. Jonathan Silverberg, an assistant professor of dermatology at the Northwestern University Feinberg School of Medicine in Chicago. "It impacts all aspects of patients' lives and may worsen their heart-health," he said. The researchers found that people with eczema smoke and drink more, are more likely to be obese and are less likely to exercise than adults who don't have the disease. The findings also suggest that eczema itself may increase the risk for heart disease and stroke, possibly from the effects of chronic inflammation, he said. "It was ... Read more
Related support groups: Heart Disease, Ischemic Stroke, Eczema
Health Tip: What's Causing my Child's Eczema?
Posted 5 Jan 2015 by Drugs.com
-- Eczema is a common condition that can cause dry, red and itchy skin. The National Eczema Association says common eczema triggers in children include: Having very dry skin. Having contact with an irritant or allergen, from smoke or pets to detergents. Having a skin infection. Drooling among babies, causing facial eczema. Exposing skin to cold, dry air. Read more
Related support groups: Eczema
Having Eczema Won't Make You Shorter
Posted 10 Dec 2014 by Drugs.com
WEDNESDAY, Dec. 10, 2014 – The skin disease eczema doesn't increase the risk of being short, researchers report. "Childhood eczema is not associated with short stature overall, although severe disease with prominent sleep disturbance is associated with higher odds of short stature in early adolescence," the Northwestern University researchers wrote. Previously, there have been conflicting results in studies looking for a possible link between eczema and height, they said. The current analysis looked at nine past studies. Those studies included almost 265,000 children and teens and more than 80,000 adults, according to the researchers. Overall, the analysis showed that eczema was not associated with significant differences in height. However, a very small number of youngsters with severe eczema who did not get enough sleep appeared to be at increased risk for slower growth. These ... Read more
Related support groups: Eczema
Infants With Eczema May Be More Prone to Peanut Allergy: Study
Posted 25 Nov 2014 by Drugs.com
TUESDAY, Nov. 25, 2014 – Exposure to peanut protein in household dust may increase the risk of peanut allergy in infants with the skin condition eczema, a new study reveals. About 2 percent of school-aged children in the United States are allergic to peanuts. And severe eczema in infants has been linked to food allergies, particularly peanut allergy, the researchers noted. The new study included 359 infants aged 3 months to 15 months. The researchers examined the amount of peanut protein the children were exposed to in household dust. The children were at high risk for peanut allergy because they were allergic to cow's milk or eggs, or had moderate to severe eczema and were allergic to cow's milk or eggs. The investigators found that exposure to peanut protein in household dust early in life doubled a child's risk of peanut allergy. The risk was highest among children with eczema, ... Read more
Related support groups: Eczema, Oral Allergy Syndrome
Eczema Cases Rising Among U.S. Children: Report
Posted 24 Nov 2014 by Drugs.com
MONDAY, Nov. 24, 2014 – A growing number of children are being diagnosed with the allergic skin condition eczema – but it can usually be eased with topical treatments, according to a new report. Eczema is a chronic condition that usually starts in childhood, and causes patches of skin to become dry, inflamed and often intensely itchy. And, studies have shown, eczema seems to be on the rise. Based on a household survey by the U.S. Centers for Disease Control and Prevention, the prevalence of eczema among kids younger than 18 rose between 2000 and 2010: from around 9 percent to 17 percent among black children; from 5 percent to 10 percent among Hispanic kids; and from around 8 percent to almost 13 percent among white children. "We don't know for certain why that is," said Dr. Anna Bruckner, one of the authors of the American Academy of Pediatrics (AAP) report. Greater awareness of ... Read more
Related support groups: Eczema
Eczema Tied to Bone Fracture Risk in Study
Posted 30 Oct 2014 by Drugs.com
THURSDAY, Oct. 30, 2014 – The skin condition eczema may increase slightly the risk of broken bones and injured joints, a new study reports. In a study of 34,500 adults, researchers found that among 7 percent of people who had an eczema flare-up in the past year, 1.5 percent had a bone or joint injury and 0.6 percent had an injury that caused a limitation of function. Compared to people without eczema, those with the skin condition had more than double the risk of having had a fracture or bone or joint injury, according to the study. "Adults with eczema have higher rates of injuries, including fractures and bone and joint injuries," said lead researcher Dr. Jonathan Silverberg, an assistant professor of dermatology at Northwestern University in Chicago. Although this study found an association between eczema and bone and joint injuries, it wasn't designed to prove whether eczema is ... Read more
Related support groups: Eczema, Fracture, bone
Taking a 'Selfie' May Help With Dermatology Care, Study Shows
Posted 22 Oct 2014 by Drugs.com
WEDNESDAY, Oct. 22, 2014 – While in-office visits may still be best, taking a photo of a skin lesion and sending it to your dermatologist for analysis may be a valuable piece of eczema care, a new study finds. "This study shows something interesting – patients' eczema improved regardless whether they saw the doctor for follow-up in the office or communicated online," said one expert not connected to the study, Dr Gary Goldenberg of New York City. The new technology "gives patients another valuable option of communicating with their doctor," said Goldenberg, who is assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai Hospital, New York City. The new study was led by Dr. April Armstrong of the University of Colorado, Denver, and published online Oct. 22 in the journal JAMA Dermatology. The study included 156 adults and children with eczema: 78 ... Read more
Related support groups: Eczema
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Iraqi women must organize in order to ensure their rights in a new democratic system, the lone woman in Iraqs Cabinet said yesterday.
"The window of opportunity was opened with the liberation of Iraq," Nasreen Barwari, minister of municipalities and public works, told a Washington luncheon audience. "Iraqi women are capable, are educated, are willing, are ready" to be a part of the political process.
As members of the Iraqi Governing Council signed an interim constitution yesterday in Baghdad that included a goal of 25 percent female representatives, a panel sponsored by the United Nations and comprising women from Iraq, Turkey and the United States used International Womens Day to call for further progress.
Panel member Judith Kipper, director of the Middle East Forum at the Council on Foreign Relations, urged Iraqi women to take advantage of existing social structures to improve their networking and to focus on empowering women economically as well as socially.
Iraqi women have demonstrated their power, using marches and protests in the past month to force the Iraqi Governing Council to repeal a law that would have made family matters subject to the strict Islamic Shariah law.
As a result, "women now feel confident," Mrs. Barwari said.
But Anita Sharma, director of the Conflict Prevention Project at the Woodrow Wilson International Center for Scholars, said these achievements must be sustained and the laws must translate into practice on the ground, something that has not always happened.
During the Baath Partys rule, the constitution technically granted many rights to women, but Saddam Hussein issued edicts that violated the constitution, including legalizing honor killings.
Postwar security issues also pose a problem for women in Iraq. Mrs. Sharma said many women are wearing tentlike robes in situations and places they wouldnt have before the war.
Authorities also worry that women will not leave their homes to vote in elections in January if they do not feel safe.
Although cultural traditions in Iraq have excluded women from social and political life, Kurdish women have enjoyed more rights than their Baghdad counterparts since the Kurdish region gained some autonomy in 1991. Mrs. Barwari, a Kurd, said they can use that advantage to push the rights of women to the forefront.
Iraqi women have made progress on the local level, winning seats on city councils in Baghdad and other communities for the first time. But whether this type of success will be repeated on the national level remains to be seen.
"My greatest fear is that the 25 percent will be reached, but by candidates put forth by men," said Rend Rahim Francke, the Iraqi envoy to the United States.
Cultural barriers to women holding power stem not only from men, but also from women, she said.
The diplomat said she is "haunted by the January 2005 date for elections," because Iraqi women dont have enough time to field independent female candidates who can persuade men as well as women to vote for them.


text:
Baseball Hall of Fame: Follow Your Own Rules, Respect Integrity and Induct Dale Murphy
by Taylor Murphy · 7,821 supporters
Decision Maker Response
Bernie Miklasz
St. Louis Post-Dispatch
Dec 7, 2012 — I have supported Dale for years and plan on voting for him again. But I must ask you: please take me off this email list. The volume of emails is interfering with my work, and frankly, it's rather rude considering my support for Dale Murphy. Bombarding voters with emails isn't a good way to sway those voters. If anything it will cause resentment. Just a sincere and friendly word of advice. Thanks.


text:
A children's book for grown-ups too. "Who are you going to be today Olive?" is a story of a little bird just learning how to be herself. With the help and support of her many friends, Olive finds her way.
Measuring 7" x 7", this is a 30 page full color book including 25 illustrations, written and illustrated by Marisa Anne Cummings.
What started out as one day a week, Thursdays, set aside to be a bit more creative while working a 9 to 5 job....Creative Thursday, has become a full time business featuring the art of Marisa Haedike, or as I like to call it a dream come true.
Comment posted.
mhaedike says Thank you Shaney! All of my illustrations in this book are acrylic on wood panel.
posted at 08:54AM Aug 09 PST
shaneyhyde says Lovely illustrations Marisa. Just delightful character is Olive. Can I ask you what media you used to do your illustrations? They are wonderful?
posted at 07:13PM Aug 08 PST
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text:
Hi Henning,
You would want to wire your ligth fixtures parallel, they all need to get 230V if you wire in series you would halve the volatage for every unit you connect in the series.
As far as the capacitor or Condensator, it is also wired in parallel or directly to the 230V.
I just build my light box but with only 8 tubes.
Hope this helps?


text:
Revlon Colorstay Eyeliner
1564 reviews
73% would repurchase
Package Quality: 3.9
Price: $$
Package Quality: 3.9
Price: $$
INGREDIENTSCyclopentasiloxane, Ozokerite, Trimethylsiloxysilicate, Polyethylene, Phenyl Trimethicone, Candelilla Cera (Euphorbia Cerifera {Candelilla} Wax), Tocopherol, Sorbic Acid, BHT, Methylparaben, Propylparaben. May Contain: Iron Oxides (CI 77491, 77492, 77499), Titanium Dioxide (CI 77891), MICA, Black 2 (CI 77266), Ferric Ferrocyanide (CI 77510), Carmine (CI 77470).
on 8/13/2014 12:58:00 AM
Age: 18 & Under
Skin: Sensitive, Fair-Medium, Neutral
Hair: Blond, Wavy, Medium
Eyes: Green
I seriously love this so much. I hate liquid liners because I make a mess, and I hate sharpening pencil liners. I love how this is retractable. I put this my bottom lash line and smudge it a bit. It smudges quite nicely, but then it really lasts a looong time the way I use it. But I've tried using this on my top eyelid, and for some reason it smudges underneath my eyes by the the end of the day, which kind of sucks. But for the way I use it, it's prefect for me.
on 7/25/2014 3:30:00 PM
Age: 25-29
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
Broke easily and did not actually "colorstay". I like Sephora's eyeliner better.
on 7/8/2014 12:35:00 AM
Age: 19-24
Skin: Oily, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Green
My holy grail pencil liner. Great black pigmentation, stays on all day long with no smudging or fading. Love that it's a twist up liner as well, very convenient. Only thing that bothers me a bit is it can be kind of hard to remove.
on 7/3/2014 1:20:00 PM
Age: 30-35
Skin: Combination, Fair-Medium, Neutral
Hair: Brunette, Other, Medium
Eyes: Brown
Been using this for years. It s the only one I have found that will stay put and doesnt transfer if i use on my top eye lid. Thats my main issues. I have tried many many kinds and this is the only one that works. I recently started using it on my eyebrows (black brown color) to fill in. Works great and even if I dont put a gel over it, it doesnt smudge or move from where I used it. Great product.
on 7/2/2014 6:28:00 PM
Age: 36-43
Skin: Normal, Fair, Neutral
Hair: Brown, Curly, Medium
Eyes: Brown
This is my HG eyeliner. I have been using it for years. It always stays put all day. I use the Cocoa everyday for work, and the Navy or Black for evening. They used to have a Vixen shade that was the perfect plum, I hope they bring it back. Today at Walgreens I found they have introduced new bright shades: Topaz, and Sapphire; both gorgeous. They have also added a new 'smudger' sponge on the tip, which is great because I usually use a q-tip after each application to get a smokey smudge with any product that ends up outside. BTW I use this to line the inside of my eyes, not the lids. GREAT.
on 6/14/2014 11:00:00 AM
Age: 25-29
Skin: Acne-prone, Medium, Neutral
Hair: Brown, Wavy, Medium
Eyes: Brown
MY HG eyeliner. I am an eyeliner whore-I feel like putting a little on makes a huge difference in how put together and awake you look lol. I have always used this eyeliner INSIDE my eye (don't do this unless you know what im talking about). What i mean is I use it on the inside bottom lining of my eye, not on top of my lashes, I use liquid liner for that. Anyways, I have always had problems with eyeliners running. This DOES NOT. I get black as I have dark features. Some complain it's not dark enough but it's super dark for me. It's easy to use as it is mechanical. The only downside is sometimes it breaks easily. Other than that, I have been using this for years now and I can't find anything better. It does not run, it's not expensive, and it works wonders. But again, I use this on the inside lining of my eye, i've tried it outside on top and it wasn't as impressive.
on 5/31/2014 7:07:00 AM
Age: 30-35
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
i'm not a makeup junkie so i can't really compare this eyeliner to higher end brands.
lasts a decent amt of time (not all day)
smudges decently (when you want it to) fine point
a bit dry
tends to flake /crumble off by end of day
on 5/27/2014 12:47:00 PM
Age: 25-29
Skin: Normal, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Blue
Color payoff is pretty nice, and the packaging is pretty decent-really handy and sleek, feels like a HE product. But too bad it doesn't even last more than a minute on my eyelids, I've never experienced such messy smudges on my eyelids before, ironical, because I'm not even oily skinned.
I think it would probably work better if you use an eye primer that is very mattifying, but no way am I bothering to do that just to experiment.
All in all, not really decent product.
on 4/17/2014 3:09:00 PM
Age: 30-35
Skin: Acne-prone, Medium, Not Sure
Hair: Black, Other, Other
Eyes: Black
This is the ONLY eyeliner I've used and currently still use, that doesn't smudge. I've tried many different brands and types of eyeliners out there. MAC, loreal, maybelline, almay, sephora, just to name a few. This eyeliner on me seems to outlast just about any environment. Humid, rain, sweaty hot, cold, you name it. I did give it 4 lippes because under extremely hot, humid conditions and worn over eye concealer it did smudge a little over my eyelid. FYI, I usually draw my eyeliner pretty thick with a winged tip. Would I recommend this product? Absolutely.
on 3/23/2014 9:13:00 PM
Age: 30-35
Skin: Combination, Medium, Warm
Hair: Brunette, Wavy, Coarse
Eyes: Brown
One of the few products I always stock up. I used to use high end liners but they ran out so fast and they are so expensive. I started searching for a good drug store eyeliner. I tried a few, I prefer retractable ones because I'm too lazy to use a sharpener and I don't like how the pencils always make a mess in my makeup bags. So far this eyeliner is the best one I've found. Good price, good packaging and it really does the job. It does run a little bit throughout the day, but I think all liners do, even the water proof ones. Maybe that's just how my eyes are. I'm very pleased with this eyeliner and will continue to repurchase it.
Popular Eyeliners
614 Reviews
339 Reviews
2175 Reviews
338 Reviews


text:
Debut Navy satin bow clutch bag
Item No.0870108069
Item No.0870108069
30% Off - Save a total of £3.00
The finishing touch to your occasion outfit, this navy satin clutch bag from Debut has a bow front with a popper fastening and a fold away wrist strap.
UK Home Delivery Free (UK orders over £30) or £3.49
Delivered within 5 working days
Next or Named Day Delivery
7 days a week between 8am - 6pm
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Collect from store the next day - FREE
Order before 9pm for next day collection after 12pm midday
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Subject to exceptions, Debenhams is happy to exchange or refund your purchase within 28 days of delivery. Please check here for more details on our returns policy and exceptions.


text: Freestyle doesn't carry the 5x7s (I wish) and I would prefer not to order from the UK, so I've been cutting my 11x14 sheets. Which is approximately 100 5x7s with a few test strips left over, for a bit less than the link above--$46.99 vs £34.95 (but I would prefer pre-cut). I have tried it in Dektol but not with the same negative that I also tested with Arista Cold Tone Developer and Zonal Pro WT, so not a very accurate test. The WT dev looks really nice, it's subtle, not greenish either. I have a few complaints about the Arista developer but I might need to do a bit more research. But yes, mine looked quite good in Dektol as well. Fantastic paper. Now I just wish it were cheaper.


text:
Amour, written and directed by Michael Haneke, has unsurprisingly carried off the best foreign film Oscar at the 85th Academy Awards in LA, the category in which it was the hot favourite.
- Amour
- Production year: 2012
- Countries: Austria, France, Germany, Rest of the world
- Cert (UK): 12A
- Runtime: 125 mins
- Directors: Michael Haneke
- Cast: Alexandre Tharaud, Emmanuelle Riva, Isabelle Huppert, Jean-Louis Trintignant
A French-language drama about an elderly married couple whose lives are shattered when one has a stroke, Amour has won a string of awards since its world premiere at the Cannes film festival in 2012, where it was honoured with the Palme d'Or.
As well as winning the best foreign film awards at the Golden Globes and the Baftas, Amour has made inroads into the main categories, with four other nominations including best original screenplay and best director for Haneke, best picture, and best actress for 85-year-old Emmanuelle Riva.


text:
We just wrapped up our first FY12 Compete Webcast onSeptember 1, 2011 where we shared Microsoft's story on "Competing in the Cloud:Microsoft vs. Google: Why it Matters to Your SMB Business". After an hourof great content the feedback we received from partners was phenomenal andprovided the foundation for our upcoming Compete Webcast!
This month we shared:
You can view the on-demand recording by clicking here. Additionally, you can down the deckused during the call by clicking here.
We invite you to join us on October 7, 2011 for our nextCompete webcast where we will dive into VMware Compete (leveraging SystemCenter for virtualization deals). GetRegistered and Attend!


text:
Kurt Readus
- Filed Under
? Kurt Readus has been selected by the U.S. Department of Agriculture Natural Resources Conservation Service as Mississippi's state conservationist for NRCS. Readus has a bachelor's degree in environmental science from Alabama Agricultural & Mechanical University. He began his career with the Natural Resources Conservation Service in 1998 as a student trainee in Arizona and Alabama. He previous as assistant state conservationish-programs in Mississippi, area conservations of central Mississiippi, district conservations in Arizona and soil conservationist in Avondale, Ariz.


text:
Published in Wearables
09 April 2015
Apple Watch trashed by reviewers
Battery life too quick, price too high, a chocolate teapot of time pieces
Apple's iWatch has failed to impress reviewers, meaning that it will be only those with their brains switched off who buy one.
16 August 2012
Big Content uses "piracy" to pull bad reviews
Google take-down is censorship
01 June 2012
Homefront 2 said to be phenomenal
Said to deliver 5X what the first one offered
18 May 2012
Cooler Master HAF XM reviewed
Review: Here, HAF an award
16 May 2012
Diablo III disappoints?
Hello Error 37
16 September 2011
Gears 3 reviews hitting
Scores as high as expected
05 May 2011
Cooler Master NotePal LapAir tested
Review: Because your lap(top) deserves it
15 April 2011
RIM Playbook gets blasted by reviewers
Bit of a rush job
16 March 2011
THQ stock reacts to Homefront release
Stock falls as review scores are all over the place
12 January 2011
PowerColor HD 6870 PCS+ tested
Review: Batmobile in action again


text:
Who can issue a stop notice?
Construction Lien Law: What You Need to Know to Protect Your Company
RALEIGH'S UDO AND THE CITYWIDE REZONING: What's New and How's it Working?
2014 Construction SuperConference Recap and Lessons for 2015
Litigation of Construction Delay: Claims of Delayed Early Completion
Winning Formula for Construction Litigation – Lessons Learned from a Recent Trial Win
Polsinelli Podcasts - How Stop Work Laws May Impact the Construction Industry
California Court of Appeal Opens Doors for Construction Defect Claims Outside of the Right to Repair Act
Grayson: Only 1 Agency Should Regulate Wall Street
Transbay Tower Groundbreaking
Minimizing Risks in Guaranteed Maximum Price Contracting
Money Talks: Safe Places & Breach of Security (Part I)
Allen Matkins partner Ray Buddie - San Francisco Construction & Development Summit
DPR Construction EVP Eric Lamb - San Francisco Construction & Development Summit
Shorenstein SVP Todd Sklar - San Francisco Construction & Development Summit
Sares Regis chief development officer Todd Regonini - SF Construction & Development Summit
Hathaway Dinwiddie CEO Greg Cosko - San Francisco Construction & Development Summit
The Benefits of WRAP Insurance on Large Construction Projects - Ray Buddie
Forest City SVP Alexa Arena - San Francisco Construction & Development Summit
Google real estate director John Igoe - San Francisco Construction & Development Summit
Pennsylvania's Contractor and Subcontractor Payment Act ("CASPA") is a powerful tool for contractors and subcontractors to ensure that they receive prompt payment for their work and may entitle them to expansive remedies,...more
In what appears to be the first decision of its kind, an ICSID tribunal in the case of Muhammet Çap & Sehil Insaat Endustri ve Ticaret Ltd. Sti. v. Turkmenistan has ordered the claimants in the proceedings to disclose the...more
In a case involving a dispute over steel production to replace a portion of the Whitestone Bridge spanning New York City's East River, a federal district court remanded an arbitration award back to the arbitrator. Under the...more
On April 21, 2015, the Missouri Court of Appeals in City of Chesterfield v. Frederich Construction Inc. upheld an arbitration award that included substantial attorneys' fees to the prevailing party, in a construction case...more
"Reduction in Force" Employment Discrimination by Federal Contractors – "In situations involving a reduction in force, a modified prima facie formulation may apply, which allows a case of discrimination to be established by...more
On July 31, 2014, with a stroke of his pen, President Obama promulgated new rules targeting government contractors who commit "serious," "repeated," "willful" and "pervasive" violations of laws regulating the workplace. The...more
The July 31, 2014, executive order, "Fair Pay and Safe Workplaces," introduces a broad federal contractor reporting scheme that alters the relationship between prime and subcontractors, creates an obligation for contracting...more
The Middle District of Florida recently, in U.S. Surety Co. v. Edgar, provided a practicum on arbitrability jurisprudence under the Federal Arbitration Act, answering key questions about (1) whether nonsignatories to an...more
The current state of Italian project finance is the result of a trend initiated more than 20 years ago, when public resources started to become scarce and the construction or infrastructure needed private funds to be carried...more
An article comparing the contract administration and project management roles found in JCT, NEC and FIDIC.
May be of most interest to those in the process engineering industries....more
The latest in legal news from Hawaii, via the Damon Key Legal Alert. Stories on Construction law, bid protests, and the legal issues surrounding allegedly defective drywall. ...more
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