text:
Glenfiddich has always appreciated the value of time. In 1886, having gathered 20 years of whisky making experience, William Grant set out to create "the best dram in the valley". Within a year he had built his distillery in The Glen of Fiddich - Gaelic for The Valley of the Deer. The first spirit flowed from the stills on Christmas Day 1887.
Today, having pioneered the single malt category, Glenfiddich Single Malt Scotch Whisky is the jewel in the crown of the William Grant's brand portfolio and the most awarded Single Malt Scotch Whisky in the world. It is also the best selling Single Malt Scotch Whisky in the world
A fragrant malt which balances the fruitiness of pear with the richness of subtle oak.
Nose: Distinctively fresh and fruity with a hintr of pear. Beautifully crafted single malt with a delicately balanced fragrance.
Taste: Characteristic sweet, fruity notes. Develops into elements of butterscotch, cream, malt and subtle oak flavour.

subset: commoncrawl


text:
Chapter 1
(I don't own anything in this story - Hogwarts and everything to do with it belongs to J.K. Rowling) This is my first actual story on here, so don't forget to vote/comment! If you do, somewhere, out there, a penguin will smile. You don't need much more reason than that.
"Last year at Hogwarts!!"
"Quiet down guys, you're acting like first years..."
"Who cares? This year is gonna be the best!" A lopsided grin stretched across Joey's face - his crooked jaw making the bottom half of his face slightly askew.
"Heck yeah it is," Darren replied as they loaded their hand luggage above their heads and collapsed into the soft train seats.
Bonnie rolled her eyes at the two boys sat opposite her - they'd already changed into their robes, enjoying the funny looks that they got from passing by muggles as they steered their luggage trolleys across Kings Cross Station. Darren found it particularly hilarious when Joey's cart had hit a pothole and ended up with him lying flat on the ground amongst the crowd of busying people - who understandably, ignored him.
Suddenly, they felt the floor of the train begin to rumble slightly...
"Oh gaawwd," Joey's face screwed up into a scowl, "it's Bieber," he said his name like it was disgusting to taste in his mouth. Bonnie and Darren looked at each other, their brows furrowed.
Sure enough, Justin Bieber hurried past their comparment, disappeared after a sly wink at Bonnie, followed by what could only be described as a herd of girls all stampeding after him, sqealing and giggling as they went. Their thundering footsteps could be sensed from twenty compartments away.
"It's ridiculous, all those girls chasing him, just pathetic, such an asshole, stupid hair, lesbian," Joey grumbled to himself. He crossed his arms and looked out the window at the passing countryside. Neither of the other two argued with Joey's childish retorts; Joey had hated Justin ever since they had sat next to each other at the Gryffindor table in their first year.
Justin had been extremely arrogant at the time and had chatted up every girl in sight, including Bonnie, and then proceded to fling mashed potato at fith years and blame it on Joey.
Darren patted him on the shoulder, he understood more than Bonnie, who had tutted and gotten out her History Of Magic book. She hated Justin just as much as Joey, but even she had crushed on him in the past.
"Oh buggeration..." Darren sighed, exasperated.
"What is it?"
"I'm supposed to be in the head students compartment," he replied, fishing around his pockets for his Head Boy badge.
"Darrren! You didn't tell us you got Head Boy!" Bonnie exclaimed, smiling widely as he pinned his badge onto his robes, the gold and scarlet metal shining from polish. Darren shrugged, he knew how much Bonnie had wanted to be Head Girl, and how disappointed she was when she didn't get her badge in the post.
If he was honest, he would rather it was her than him that had to patroll the corridors at night, checking on students and making sure everything was fine and dandy.
He made his way down the train until he got to the compartment that Slughorn was sat in. He slid open the door just enough and squeezed in - wanting to draw as little attention to himself and his tardiness. However there was only Profesor Slughorn and another girl.
"Ah, Mr Criss," Slughorn said delightedly, "congratulations on becoming Head Boy!" He shook Darren's hand and his large stomach seemed to shake with them.


text:
WalGreens RPh argued with this Mom. "The dose is correct. I listened to the Doctor's Message Twice" Fortunate for the child, "My Mommy is a Pharmacist".
California Board of Pharmacy June 24, 2015,
Public Comment on Items Not on the Agenda/Agenda Items For Future Meeting
Aglaia Panos Pharm D, preceptor at Touro University College of Pharmacy for Pharmacist Planning Service Inc (PPSI).
I would like to request a special hearing on prescription drug errors. I have become increasing concerned about my students that have been doing an internship with me for the past 6 years at Pharmacists Planning Service, Inc (PPSI). They have been telling me about the increasing number of prescriptions they have to fill in chain pharmacies with less pharmacy and technician staff and as a consequence less oversight. Meanwhile, the pharmacist's duties have increased as they are now often required to do immunizations, scrutinize drugs more carefully for abuse as required by the DEA and Board of Pharmacy, answer questions on Medicare Part-D and spend more time on phones with insurance companies and part D plans for $4.00.generic prescriptions. Furthermore, Chain pharmacies are putting 10-15 minutes limits on getting the prescriptions out the door.
Last Sunday, June 21, I went to a WalGreen's at 8:00 pm to pick up a prescription for my son. It was a Nystatin 100,000 units per 5 ml. This was a new prescription and I was not offered a consultation when the technician gave it to, me. I opened the bag and read the directions and said the directions do not make sense. It read to swish 25ml in the mouth then to swallow four times day. I asked to speak with the pharmacist who kept reassuring me that the recording by the doctor did in fact say that, and that she played it more than once. I asked her if she had ever prescribed such a large dose, and perhaps she should check with the doctor again. She insisted that she had done the math correctly and that a teaspoon was 5 mls and 5 teaspoons is 25 mls and she dispensed the correct amount which was 1000 mls of Nystatin, in two individual pint bottles for the duration of the 10 days.
I called the doctor that night and left a message. My son only took 5 mls that evening. The next day the same pharmacist called before 9:00AM and said the chain pharmacy got really busy last night with her having one technician to help fill all the prescriptions in the store. She went on to say how busy they there were long lines waiting prescriptions and she also had to service the drive through window. and it almost was closing time at 9:00pm. She said to wait until she contacted the doctor. She later again called to my son and told him to take only 5 ml and if he wanted to bring in the two pint bottles she would change correct the label.
One of the best selling books of the year is by Dennis Miller, a pharmacist ,called Chain Drug Stores Are Dangerous. I have a copy here and if you have not read I suggest you buy a copy. This book should be given to all state board of pharmacy members. inspectors and investigators. as required reading
I would like to thank you for considering a hearing on medication errors at your next available subcommittee hearing.
Aglaia Panos firstname.lastname@example.com
You can find a link to the Amazon page that has Miller's book for sale under BLOG ROLL in left margin Heading is LINKS. JP


text:
The South is rising in USThe march of Americans to the south and west of the US is gathering pace with census data showing that seven out of the 10 largest cities by population are within 500 miles of the Mexican border.
Florida sheriff sends out posses to flush out illegal immigrantsWith the US Senate bogged down in a debate about what to do with the country's 12 million illegal immigrants, a sheriff in a small town in Florida has been testing a new and somewhat controversial solution to the crisis.
International p27
Newsreader's anger over Paris story
A US cable news presenter refused to read out a lead story on the release of Paris Hilton from a Los Angeles jail. By Dan Glaister.
Iran urged to end petrol rations after violent unrestThe Iranian president, Mahmoud Ahmadinejad, was under pressure to perform a U-turn on petrol rationing yesterday after the restriction prompted violent protests at filling stations across the country this week.
Israeli president in deal to avoid prison term and rape case· Katsav to resign before admitting harassment
· Women's rights groups attack plea bargain
Three British troops killed on Basra patrolThree British soldiers were killed yesterday, and one seriously injured supplying a base in the Iraqi city of Basra which UK forces are expected to leave soon.
International p28
Quiet Spanish city is Europe's coke capital· Miranda de Ebro second only to New York says UN
· Study of waste water is mistaken, say residents
French judge heeds the cockerel's callFrench judge rules in favour of crowing cockerel after a 70-year-old woman and her son accused it of ruining their life.
International p29
11 hostage MPs killed in crossfire during raid on Colombia rebel camp· Lawmakers abducted by Farc five years ago
· Guerrilla kidnappers offer condolences to families
Blood on the streets as drug gang and police fight for control of Rio favelasBrazilian authorities have launched one of their biggest offensives against drug trafficking, invading a network of shantytowns in Rio with tanks, helicopters and around 1,350 soldiers.
International p30
Chávez hints at nuclear future for VenezuelaPresident Hugo Chávez yesterday hinted that Venezuela could try to become a nuclear power, during a visit to Russia apparently timed to antagonise the White House.
Squashes show ancient farming in South AmericaAgriculture was taking root in South America almost as early as the first farmers were breaking ground in the Middle East, research indicates.
Thais hang hopes of good fortune around necksThailand's devout - and less than devout - cannot get enough of the amulets believed to have magical powers to ward off bad fortune and bring riches.
International p31
Bald eagle wins 40-year fight for survival
The United States has removed its national symbol - the bald eagle - from the country's list of threatened species, after a 40-year fight for survival.
Opera House makes expanded listThe Opera House in Sydney and India's ancient Red Fort Complex were among four sites added to the United Nations World Heritage list yesterday.
Poll of Democrats reveals Gore could still steal the show· Clinton would be big loser if ex-vice president ran
· Republicans also unhappy with current candidates


text:
|Reviews for Abducted
| Lilyflower08 chapter 1 . 8/29
Oh my gosh! I just finished reading your poahontas story and I just realized you have written some of my favorite Disney fanfictions!
| the Oracle of Akemi chapter 29 . 2/14
That was a GREAT story. Poor Aurora, (at first) happy Adrian. The cycle goes on...
| Thrae Elddim chapter 29 . 6/4/2014
This had to be one of the cutest things ever while at the same time being heart-wrenching and mysterious and... Everything. Just amazing. Thanks for sharing!
| Shiori Kudo chapter 26 . 5/29/2014
So, are Eugene and Edward brothers or cousins? Because you've been using both and it's kind of confusing.
| Shiori Kudo chapter 15 . 5/29/2014
I liked the lantern scene.
| Shiori Kudo chapter 1 . 5/28/2014
Your grammar is very good. The only things I noticed was that you used "sheds" instead of "shades", and that "I've to admit, your daughter isn't a proper princess!" needs "got" or you need to break up "I've" into "I have". Also, it was kind of difficult to tell what were thoughts and what was spoken. You should make that a little clearer.
| Addira chapter 29 . 5/18/2014
BAAHAHAAHAHAA That fucking ending!
That is just perfect holy crap! Best line of the whole story right there.
Goddamn gimme a moment to collect myself.
Ok, ok, on with the review.
To be honest I'm surprised I read the whole thing. I'm not usually one for fluff and typically grammar mistakes and errors tick me off to the point of utter story abandonment. But I stuck it out (and I had to take many pauses to digest the fluff - but that's just me! Fluff is good, don't get me wrong.) and I'm glad I did.
That ending. All of the fucking awards to that ending.
If I had to say anything constructive to this whole thing would be to address the lack of debonair Flynn. He had his transition into Eugene fairly quickly. I was hoping, chapter per chapter as I read, that Eugene would slip back into Flynn's mindset but it never happened which kind of took me out of the story. He was Flynn for so long and then POOF! 3 chapters later he is a stricken puppy called Eugene who had no recollection of being Flynn Rider. (But if his transition was made in haste to please the "fluffers" then I suppose it's alright.)
Another thing that slightly took me out of the story was your use of "I've" or "We've"... sometimes it's just better if you write it out completely. I don't have a concrete example where you have done this (because I forgot where you wrote it down and I'd have to go back and hunt them down) but if you'd like I could find them and explain which grammar road you could have taken to avoid many of the easily avoidable grammar mistakes you have made. (It's alright, it happens to everyone.)
Love the cliffhangers.
"Maybe" is one word, there is no space. (I saw this a couple times too.)
Also last thing before I get too annoying (It tends to happen and I apologize), you don't need to ask at the end of your chapter for people to favourite and review. Just be your charming self and try to avoid grovelling and begging. For example:
"Reviews/Faves/Follows... Plz...Plz...Plz. I love them." - Acceptable.
"Review to get more." [Chapter 17] - You can easily tick off people with that.
It's understandable that the more reviews you obtain, the more motivation is put into the next chapter but 'fishing' for reviews isn't exactly a good thing either. If someone was just leisurely reading this story and saw that it could be a deal breaker.
So yeah, that was that.
The positives are so numerous and I'm only going to brush the surface but: the storyline was amazing, the characters were believable, debonair Flynn (when he was there) was perfection, how you tied in all the characters from the feature film was awesome, how you constantly put your two protagonists in peril and danger was awesome - keeps us on our toes, you can tell the characters were frustrated beyond all frustrations and that is just awesome as well, your time skips were appropriate and were always used as a plot device and never because they were convenient at that point in time, you never made it too awkward to read in a public place (this is a problem I've encountered many times in other stories), and last but not least you managed to get over 90,000 words down and stuck it out to the end, thus finishing your story.
*standing ovation of epic clapping* Bravo! Bravo!
**throws flowers everywhere**
| Guest chapter 29 . 5/17/2014
Oh my goodness, this was so adorable! The ending was superb! I love how it brings it back full circle by saying abduct her in full cycle. Throughout the piece your writing has improved and it's been very enjoyable to read! So cute. THank you for your writings ! (:
| Guest chapter 13 . 5/16/2014
dude you don't understand because i don't really leave review for ppl but your story is adorable and i love that they love each other! agh
| daianapotter chapter 2 . 1/14/2014
jajaja very funny xD
| daianapotter chapter 1 . 1/14/2014
i really like this story _
| A Battle Inside My Heart chapter 29 . 1/3/2014
This is the best tangled fanfiction I have ever read! I seriously love the endin and of my gods it was just freaking amazing!
| 123hereigo456 chapter 29 . 12/23/2013
I absolutely loved it!
| I'm A Fluffy Panda chapter 29 . 12/17/2013
| I'm A Fluffy Panda chapter 3 . 12/13/2013


text:
Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
Dig Boom 2.0 (Swag My Team) R-R-R-REMIX!!!!
Discussion in 'BW Other Teams' started by Lucien Lachance, Jan 11, 2013.


text:
Thank you for your interest in a career with Discover. We appreciate your curiosity about our organization. We are proud of our reputation as an employer of choice, providing our employees with the careers, environment, challenges, growth and development opportunities, as well as the rewards, they deserve.
Ours is a collaborative, high-performance culture that supports and encourages hard work, dedication, development and cross-functional movement to provide our employees with breadth of experience and our organization with depth of knowledge and skills from our diverse employee base.
Evaluate for yourself whether Discover is a good fit for you and your career aspirations - our Staffing Process provides qualified individuals with the opportunity to learn first-hand about our career opportunities, employee benefits, our unique corporate
culture and more.
Here is an overview of what you can expect when applying for a position at Discover:
Thank you again for your interest!
Discover Financial Services is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, among other things, or as a qualified individual with a disability.
Equal Employment Opportunity is the law.
Please let us know if you require a reasonable accommodation to apply for a job. Examples of reasonable accommodation include making a change to the application process, providing documents or job listings in an alternate format, using a sign language interpreter, or using specialized equipment. Please email us 2-3 available times and the best method to reach you: firstname.lastname@example.com. Thank you!
Find Us on Facebook
Connect with us on LinkedIn
Sign Up for RSS Feeds
Privacy Policies | ATM Locator | Security | Terms of Use | Information For Merchants | Affiliate Program | Site Map
Discover Products:
Credit Cards | Small
Business Credit Cards | Gift Cards | Savings
Discover Financial Services: Our Company | Investor Relations | News Room | Community Affairs | Careers
© 2015 Discover Bank, Member FDIC


text:
A consumer alert for milk drinkers. Ozark Mountain Creamery is issuing a voluntary recall of 500-gallons of its skim milk.
The green cap containers have a sell by date of October 24th.
Routine lab results show the milk may not have been fully pasteurized, according to the company.
The milk was sold in stores across the Ozarks.
Customers can return the milk for a full refund.


text: It was the 2A, FP-26, and FP-26B that had fairly flat output from 15 to 30ms for use with focal plane shutters. The Press 25, M25, M5, and 25 peaked at about 20ms, with half-power points at about 15 and 30ms. The M2 peaked at about 13 ms, and the SF at about 7ms.


text:
I want to commend the many readers of this fine newspaper who take the time and trouble to write in with concise recaps of the week's Rush Limbaugh and Glen Beck programs.
Rather than wasting many hours of my time listening to their redundant, relentless, ridiculous attacks on common sense and common decency, I can peruse a few letters from your more gullible readers, have a couple of good chuckles with my morning coffee, and get on with my day!
Paul Gregutt
More like this story
sredar 3 years ago
Ditto, always good for a laugh, sometimes painfully so.
bluedevilcfmy 3 years ago
I saw this on a bumper sticker once & loved it- "I will take drug counseling from Rush Limbaugh before I take financial counseling from Obama."
chicoli 3 years ago
I saw this on a bumper sticker once and wondered! " Rush Limbaugh is a big, fat bimbo" . He is still in denial, therefore unable to give anyone drug counseling...from a big, fat bimbo?
huntinwr 3 years ago
Wouldn't he be a "mimbo" - a male bimbo? :)
barracuda 3 years ago
Make that a VERY rich "Mimbo"..... Somebody out there thinks he is right.... Or he would be off the air....


text:
Solving Laptop Larceny
If your laptop is stolen, with your confidential data, several companies will help you get it back – or else disable it.
10 comments
Discover one of our 28 local entrepreneurial communities »
Be the first to know as we launch in new countries and markets around the globe.
Interested in bringing MIT Technology Review to your local market?
Unsupported browser: Your browser does not meet modern web standards. See how it scores »
You're automatically an Insider. It's easy to activate or upgrade your account.Activate Your Account
It's the new way to subscribe. Get even more of the tech news, research, and discoveries you crave.Sign Up
Find out why MIT Technology Review Insider is for you and explore your options.Show Me


text:
Outcomes After Double Unit Unrelated Cord Blood Transplantation (UCBT) Compared With Single UCBT in Adults With Acute Leukemia in Remission. An Eurocord and ALWP Collaboration Study [Abstract 910]
One of the most significant limitations of cord blood transplantation, a procedure in which stem cells are collected from the umbilical cord and placenta after a baby is born, is that each cord blood unit contains limited volumes of blood, which translates into limited stem cells available for transplantation. The number of stem cells needed for a successful cord blood transplant is largely dependent on the size and weight of the patient. Often times hematopoietic stem cells from one cord blood donor are not sufficient to transplant one adult patient. In order to increase the number of cells, adult patients may need to receive two units of cord blood from two different donors.
Previous research from the University of Minnesota has shown that patients with acute leukemia who receive a double infusion of stem cells through an unrelated cord blood transplant have a lower incidence of relapse and a similar rate of leukemia-free survival, but a higher incidence of acute graft-versus-host disease than patients who receive a single cord blood stem cell transplant.
In order to confirm these findings, an analysis of outcomes from a larger population of patient outcomes was conducted to evaluate the benefits of a double unrelated versus a single unrelated cord blood transplant. Researchers from Eurocord, an international registry that collects and validates data from cord blood transplants, and the Acute Leukemia Working Party (ALWP), one of the specialized working groups of the European Group for Blood and Marrow Transplantation (EBMT), collaborated to retrospectively analyze data. This stu
|Contact: Lindsey Love
American Society of Hematology


text:
Research supports a good night's sleep as a crucial program design element for optimal performance.
"People say, 'I'm going to sleep now,' as if it were nothing," said comedian George Carlin. "But it's really a bizarre activity. For the next several hours, while the sun is gone, I'm going to become unconscious, temporarily losing command over everything I know and understand. When the sun returns, I will resume my life."


text:
Hi there, i am student, love arts in all forms. Has finished average art education. Programmer, interior designer, some knowledge about painting, at free time create mods on Source engine(tm) and scroll 9GAG(tm), sometimes watch MLP oh... just kidding. Favorite games: All from Valve(tm) especially TF2, Dota2, L4D (<<Tms). Sorry for my poor english.
No one is friends with DrAg()N awww. You should invite your mates to the site, or make new ones.


text:
The Sequel to the Girl With the Dragon Tattoo Trilogy Is Coming
On August 27.By Sean Fitz-Gerald
On August 27.By Sean Fitz-Gerald
Are you watching a David Fincher film, or are you just in Sears?By Nate Jones and Abraham Riesman
Since Stieg Larsson's The Girl With the Dragon Tattoo became a publishing phenomenon in 2009, a few others have borrowed the title.
He wants a raise, while the studio wants a cut.By Jesse David Fox
Look, she has hair again!By Charlotte Cowles
Can Seal still do the music?By Eliot Glazer
And see Jean Dujardin dance.By Sarah Frank
Don't show your mom. She loved The Help.By Eliot Glazer
Every year, some gamine, non-blonde actress with big eyes is inevitably likened to Audrey Hepburn. Enter Rooney Mara, 2012.By Stella Bugbee
The Girl Who Played With Fire screenplay is done; the other one with a really long name is being written.By J. Paul O'Connor
More Lisbeth.By Amanda Dobbins
Mission Impossible wins the weekend, again.By Claude Brodesser-Akner
"We had to be really sure that the nipple piercing was in the place where it was going to catch the light."By Kyle Buchanan
BRAMMM! BRAMMM!By Kyle Buchanan
Nobody bought A Zoo.By Kyle Buchanan
And four other talking points to chew on.By Kyle Buchanan and Willa Paskin
If Carey Mulligan were The Girl With the Dragon Tattoo, she would wink flirtatiously. Just like Lisbeth! (Or not at all.)By Eliot Glazer
Finally, an actress with an original look, who isn't afraid not to shun floor-length sparkle gowns and borrowed, atrociously flashy diamonds.By Amy Odell
The novel was a best seller with women, but the marketing seems to be scaring them from David Fincher's film.By Claude Brodesser-Akner
Says Rooney Mara, "There was a lot of discussion that went into my merkin for the movie, because I was naked quite a lot."By Kyle Buchanan


text:
|Sort By:
|View: List | Grid
1. Frankly - Just Between Us
Sinatra's conductor reveals what it's like to work for legendary singers Frankly - Just Between Us, is an entertaining and insightful behind-the-scenes look at the world of... more info$24.95 add to cart
Usually ships within 1-2 business days
My Life Conducting Frank Sinatra's Music. General Book (not sheet music). With Hardcover. 6x9 inches. 214 pages. Published by Hal Leonard. (HL.00331275)
2. Marketing Beyond Your Front Door
The best of Bob Popyk's columns from The Music Trades magazine from 2000-2008! It's one thing to just wait for the next customer to walk through the door. It's another thing... more info$14.99 add to cart
Temporarily Out of Stock
Practical Advice for Music Retailers and Salespeople. Special Products. With BOOK. 6x9 inches. 220 pages. Published by Hal Leonard. (HL.00332816)
3. 50 Ideas To Train Your Sales Staff In The Retai Music Industry Products Industry$14.99 add to cart
Usually ships within 1-2 business days
Softcover. Published by Hal Leonard. (HL.00333532)


text:
Best of News
Indian soldiers salute as they pay their respects to fallen comrade... News PhotoArmy Soldier,Ceremony,Conflict,Horizontal,India,Kolkata,Respect,Saluting,Srinagar,War,West BengalPhotographer DIBYANGSHU SARKARCollection: AFP 2013 AFPIndian soldiers salute as they pay their respects to fallen comrade Late Sepoy Adwaita Nandi, who was who was killed in Srinagar on June 24 with seven other soldiers, during a ceremony in Kolkata on June 27, 2013. The fallen soldier's widow, 22-year old Piu Nandi, commited suicide following the news of her husband's death. Militants staged an attack June 24 on a troop convoy on the outskirts of Srinagar, killing eight soldiers and wounding 13 others on the eve of a visit by Prime Minister Manmohan Singh. AFP PHOTO/ Dibyangshu SARKAR (Photo credit should read DIBYANGSHU SARKAR/AFP/Getty Images)


text:
Posted: Wednesday, July 24, 2013 3:48 PM
28 yr old handsome man looking to make women feel special and relaxed. I will all of your stress with a full body massage and more from my strong hands (and more) leaving you more than satisfied and coming back for more. Share your fantasies with me, im not shy 100 hh 160h contact me ladies.
• Location: eureka, Humboldt County
• Post ID: 4580691 siskiyou


text:
Brain fitness program that improves driving now includes personalized
progress tracking
SAN FRANCISCO, Nov. 13 /PRNewswire/ -- Effective immediately, Posit Science Corporation will begin shipping InSight Version 1.1 for Windows. This new release includes enhancements that enable users to closely track and understand the brain fitness gains they are making as they progress through the software, providing a highly personalized user experience.
InSight is a brain fitness software program that improves visual processing and memory. People's ability to take in and respond to what they see depends as much on the brain as the eyes. InSight speeds up and sharpens the brain's visual system so that people see more and react faster to what's around them, such as a child wandering into the street. Using InSight positively impacts essential daily activities, especially driving. In fact, InSight has been proven to cut the risk of auto accidents in half by dramatically improving driving performance.
InSight 1.1 allows users to track every step of their training experience through customized progress update messages. It also informs users about how the cognitive improvements they are making in the exercises will be expressed in everyday activities, such as grocery shopping, playing sports and driving.
Sixty-three year old Linda Stack is certain using InSight makes her a safer driver. "Lately, my peripheral vision was not what it should be," she said. "It was noticeable, especially when I was driving. I didn't want my wake up call to come when I had an accident so I was excited to try InSight. It has given me confidence and makes me feel that I can drive safely."
This new version of InSight also gives program participants flexibility to use InSight on more than one computer. Users can download their exercise data to pick up their training where they left off.
"We heard across the board from customers who
|SOURCE Posit Science Corporation
Copyright©2008 PR Newswire.
All rights reserved


text:
List of Things Batman Returns got Right/Wrong
View Single Post
I'm the real Peterman.
Join Date: Jan 2011
Location: Wellington, NZ
Posts: 3,018
Re: List of Things Batman Returns got Right/Wrong
Originally Posted by
In the fight with Catwoman, when Bats knocked Catwoman down, and she exclaimed "How could you! I'm a woman!" and he went to apologetically help her up, and she copped a sneak shot at him, I found that to be way out of character for Batman, he's much too smart a fighter to fall for such an obvious ploy (the equivalent of "Hey! Look out behind you!"). I don't care if she is indeed a woman, and generally speaking, Batman may indeed be a "Gentleman" in a non-combat situation, in the middle of an all out fight, his opponent's gender is not going to matter to him one little bit.
Well, violence against women is probably not something that Batman cares too much for. In the heat of the moment he may have been shocked by the fact that he hit her (not something he would normally do)... and maybe he thought she was attacking him because she felt threatened by him. I don't think Catwoman was clearly a "villain" yet to him at that point in the film.
View Public Profile
Send a private message to Ponyboy
Visit Ponyboy's homepage!
Find More Posts by Ponyboy


text:
share:Remind Me
TCMDb Archive MaterialsView all archives (2)
Shop tcm.com
Too Many Girls - NOT AVAILABLE
Our records indicate this title is not available on Home Video. Vote below for it to be released on DVD.
- Total votes: vote now!
- Rank: (why vote?)
Screenplay Info
powered by AFI
Based on the musical Too Many Girls by George Marion, Jr., music by Richard Rodgers, lyrics by Lorenz Hart (New York, 18 Nov 1939).
Please support TCMDB by adding to this information.Click here to contribute


text:
Phase 1, Open-Label, Dose-Escalation Study of CP-870,893 in Patients With Solid Tumors
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
CD40, a member of the Tumor Necrosis Factor receptor superfamily, is expressed on many tumor types, including melanoma, prostate, colon, breast, renal, pancreatic, and nonsmall cell lung cancers. In preclinical models, activation of CD40 results in increased antigen presentation and induction of apoptosis. CD40 is also expressed on antigen presenting cells (APCs) (B cells, dendritic cells, monocytes) and is a key regulator of both cellular and humoral immune responses. Activation of CD40 by CP-870,893, an agonistic anti-CD40 monoclonal antibody, enhances host immune responses and abrogates the growth of tumors independently of the expression of CD40 on tumor cells. Therefore, it is hypothesized that therapeutic intervention with CP-870,893 may be beneficial to a large number of cancer patients either through an immunomodulatory effect or through a direct effect on CD40-positive tumor cells.
Advanced Solid Tumors
Drug: CP-870,893
Phase 1
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|Phase 1, Open-Label, Dose-Escalation Study of CP-870,893 in Patients With Solid Tumors
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Men and women at least 18 years old with advanced solid tumors relapsed or refractory to standard therapy or for whom no effective therapy exists;
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1;
- Adequate bone marrow function documented within 2 weeks prior to treatment, defined as:
- White blood cell (WBC) count >3000 cells/μL without growth factor support;
- Absolute neutrophil count (ANC) ≥1500/μL without growth factor support;
- Platelets >100,000/μL without growth factor support; and
- Hemoglobin ≥10 g/dL;
- D-dimer WNL;
- Adequate renal and hepatic function documented within 2 weeks prior to treatment, defined as:
- Total bilirubin <1.5 times the upper limit of normal (ULN);
- Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) <2.5 × ULN;
- Creatinine clearance (CLcr, measured or calculated) >80 mL/min; and
- Life expectancy of at least 12 weeks;
- Fully recovered from the acute effects of prior cancer therapy: 4 weeks for chemotherapy (8 weeks for mitomycin C or nitrosoureas), 10 days for prior palliative radiation therapy or hormonal therapy, and 4 weeks for prior immunotherapy or other biologic therapy; and
- Signed written informed consent.
Exclusion Criteria:
- Previously treated with any other agent that targets CD40;
- Concurrent treatment with any anticancer agent;
- History of autoimmune disorder, including pemphigus vulgaris, systemic mastocytosis, systemic lupus erythamatosus, dermatomyositis/polymyositis, rheumatoid arthritis, systemic sclerosis, Sjörgen's syndrome, vasculitis/arteritis, Behcet's syndrome, inflammatory boweldisease, autoimmune thyroiditis, multiple sclerosis, or other chronic inflammatory disease;
- Treatment with any other investigational therapy within 4 weeks prior to baseline;
- History (within the previous year) of congestive heart failure, stroke, or myocardial infarction;
- Patients with known hereditary or acquired coagulopathies (eg. hemophilia, von Willebrand's disease, cancer-associated DIC, abnormal D-dimer);
- Patients with known brain metastases. Patients with clinical evidence suggestive of new brain metastases prior to enrollment are excluded if brain metastases have not been ruled out via CT or MRI. Patients with previously diagnosed brain metastases are eligible if they have completed their CNS treatment and have recovered from the acute effects of radiation therapy or surgery prior to the start of study medication, have discontinued corticosteroid treatment for these metastases for at least 4 weeks, and are neurologically stable;
- Patients having reproductive potential who are not using an effective method of birth control or who are pregnant or breastfeeding or have a positive (urine or serum) pregnancy test during baseline;
- Known sensitivity to immunomodulating agents or monoclonal antibodies;
- Alcohol abuse or illicit drug use within 12 months of enrollment;
- History of serum creatinine ≥2 mg/dL for any duration and for any reason;
- Patients, other than menstruating females, with urine dipstick 1+ or more positive for blood or 2+ or more positive for protein;
- Patients with clinically significant presence of granular or cellular casts in centrifuged urine sediment;
- Patients with renal carcinoma or renal metastases;
- Patients that have had a partial or complete nephrectomy;
- Patients requiring dialysis (peritoneal or hemodialysis);
- Prior treatment with Amphotericin B or cisplatin;
- Patients with history of insulin-dependent diabetes for greater than 5 years;
- Concomitant treatment with systemic high dose corticosteroids or treatment with systemic corticosteroids within 4 weeks of baseline;
- Concomitant treatment with anticoagulants, such as coumadin or heparin, except to maintain patency of in-dwelling catheters;
- Prior allergic reactions attributed to compounds of similar chemical or biologic composition to study drug (eg, rituximab or immunoglobulin G);
- Ongoing or active infection;
- Required the use of systemic antibiotics or antifungals for ongoing or recurrent infections.
Topical use of antibiotics or antifungals is allowed;
- Other uncontrolled concurrent illness that would preclude study participation; or
- Psychiatric illness or social situation that would preclude study participation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02225002
|United States, Pennsylvania
|Abramson Cancer Center of the University of Pennsylvania
|Philadelphia, Pennsylvania, United States, 19104
|Principal Investigator:
|Robert Vonderheide, MD
|Abramson Cancer Center of the University of Pennsylvania
No publications provided
|Responsible Party:
|Abramson Cancer Center of the University of Pennsylvania
|ClinicalTrials.gov Identifier:
|NCT02225002 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 22, 2014
|Last Updated:
|August 22, 2014
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Abramson Cancer Center of the University of Pennsylvania:
refractory to standard therapy
no effective therapy exists
ClinicalTrials.gov processed this record on October 02, 2015


text:
Senate Bill 1813 just passed, requiring all new cars manufactured in the US to be fitted with black box data recorders beginning in 2015.
This bill was championed, of course, by none other than our own Harry Reid.
I know, I know we need Harry Reid - he gives us so much free stuff. It is amazing that we can be bought so easily.
We would be wise to remember, however, that if we sell our souls to the government, then the government gets to tell us what to do with them.
Land of the free? Not any more!
Jesse Price, Sun Valley


text:
1516 Rock Drive
Raleigh, North Carolina, 27610
Commute to Downtown Garner
Almost all errands require a car.
It is possible to get on a bus.
Flat as a pancake, minimal bike lanes.
Score Details
1516 Rock Drive has a Walk Score of 2 out of 100. This location is a Car-Dependent neighborhood so almost all errands require a car.
This location is in Raleigh. The closest park is Anderson Point Park.
Explore how far you can travel by car, bus, bike and foot from 1516 Rock Drive.
View all Raleigh apartments on a map.
Popular apartment searches include fitness, fireplace and pool.
Find a Raleigh real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
This location is in the city of Raleigh, NC. Raleigh has an average Walk Score of 29 and has 403,892 residents.


text:
**** Kirks Championships 2013 ****
View Single Post
"The Thrill" Gavril
East Side VIP
Join Date: Apr 2011
Posts: 10,637
vCash: 303
Re: **** Kirks ESB Championships ****
Originally Posted by
So if I'm understanding correctly, the timeline would look a bit like this
Bika v s.....
Froch v kessler
Bute v stevenson
Ward v winner of bika v s....
Bute v Stevenson winner v froch v Kessler winner
Winners fight in huge unification whilst Abraham sits in the sidelines milking his belt.
For eveyone bar ward this is a good division. Ward's only meaningful fights are rematches he's already dominated. For the rest of them it's looking like some good fights are going down.
you think that scenario is likely?
Ward might not want to sit outside on all of this.
WBC might wanna strip Ward by any means, So Bute might have his WBC chance anyway.
Bika-Sjekloca is a done deal.
Froch-Kessler is a certitude.
Bute-Bika is the most likely fight to happen, his promoter is talking like it's a done deal so maybe he knows best. Bedard also said after Bika, Lucian will get Froch or Ward.
I like the stevenson fight because it get's him out of his way towards Froch and IBF(where he already got a deal for a fight in Canada), while Bika doesn't necessarily get's him a fight with Ward.
View Public Profile
Find More Posts by BeastsideBoxing


text:
In a study of Asian patients, the PDQ-8 minimal important difference (MID) – defined as the smallest difference in score that informed patients/proxies would perceive as important and would lead the patient or clinician to consider a change in therapy – has been shown to range from 5.8-7.4 points.
"The change from baseline in PDQ-8 score in the rotigotine group was within the previously established MID range, suggesting that patients in the current study would consider the improvement in HRQL achieved by rotigotine to be important. The effect sizes indicate that the PDQ-8 is a responsive instrument and that rotigotine has a clinically relevant effect on HRQL," concluded Mr. Lilliu.
In the RECOVER study, the most frequently reported adverse events were nausea (rotigotine 21%, placebo 9%), application site reactions (rotigotine 15%, placebo 4%), and dizziness (rotigotine 10%, placebo 6%). In general, adverse drug reactions reported in more than 10% of Parkinson's patients treated with Neupro® are nausea, vomiting, application site reactions, somnolence, dizziness and headache.
Preclinical data showed rotigotine increased depth of sleep in ratsPreclinical data presented at the Congress showed that continuous administration of rotigotine or pulsatile L-DOPA had beneficial effects on wakefulness and sleep patterns in a rat model of Parkinson's disease, but only continuous rotigotine decreased the ratio of alpha to delta wave sleep during slow wave sleep, indicative of increased depth of sleep. To date the clinical significance of this finding has not been established.
The study was carried out to investigate the effects of rotigotine and pulsatile L-DOPA on sleep-wake patterns in a preclinical rat model of Parkinson's disease.
After two days of base
Copyright©2010 PR Newswire.
All rights reserved


text: Sydney eScholarship Collection: http://hdl.handle.net/2123/7357 2015-10-14T04:03:38Z RB Add.Ms. 365 http://hdl.handle.net/2123/13388 Title: RB Add.Ms. 365 Abstract: "Soli Deo sanctisque eius sit perpetuo omnis laus atque gloria"--T.p. [Spain? ; 1781]. 18th century antiphonary, with 7 staves per page. The staves, and initials and subtitles, are in red ink, the notes and text in black ink. Ornamental t.p. with chronogram in red and black ink. Letter height approx. 8 mm. 7 blank leaves at the end of the pages' sequence. The antiphonary, a song book for use in a liturgical choir in the Roman Catholic liturgy, was mainly used for singing Mass or the canonical Hours (antiphonarium officii). This antiphonary was compiled and written for use in a nunnery of the Servants of Mary (Order of Servites). Description: 1 choir book (140 p.) ; 37 cm. Well preserved and carefully written late 18th century antiphonary, bound in contemporary full brown leather binding, raised back. The binding with considerable wear, upper joint fully cracked. 2015-06-05T00:00:00Z RB Add.Ms. 349 http://hdl.handle.net/2123/13387 Title: RB Add.Ms. 349 Abstract: Holograph, written on both sides of leaf. Mediaeval manuscript choirbook on vellum (ca. 53 x 36 cm.); executed ca. 1580 in Salamanca, Spain; massive binding of thick wooden boards covered with tanned leather, ruled in blind and fitted with 5 (of 8) pierced brass metal bosses to covers; leather/metal clasp (imperfect) and catch; binding slightly damaged but very large and impressive; much used with many pages thumbed and worn (12 defective but not affecting text) and repaired); some evidence of damage due to damp. "... seven very large initials the height of two or three staves in red and blue, with red and blue pen-flourishing and marginal extensions; numerous large initials the height of one stave in red and blue pen-flourished in the other colour, or calligraphic initials in black ink partially filled with green and yellow with oblique catchwords at right sides of lower margins on last versos; ten [i.e. 12] leaves with portions of blank margins cut away, approx. 12 leaves torn and sometimes with old repairs but with out loss of text, approx. 10 leaves creased in margins ..."--Bookseller's description. Text contains chants for the proper of the Mass: introits, graduals, tracts, alleluia, offertory and the communion verses, and sequences for special feats. The manuscript extends from the first Sunday of Advent to Passion Sunday (bookseller's description). Title supplied by cataloguer (from bookseller's description). Description: 1 choirbook (cc+ leaves) : vellum ; 57 cm. 22 (of 200) leaves missing in numb. sequence: 1, 11, 12, 31, 33, 40, 58, 67, 68, 70, 87, 98, 102, 109, 114, 116, 117, 132, 140, 141, 157 [but 158 supplied twice], 178, 190, [201] and later leaves. 2015-06-05T00:00:00Z RB Add.Ms. 357 http://hdl.handle.net/2123/13386 Title: RB Add.Ms. 357 Abstract: A collection of 30 leaves from an antiphonal. [Spain? ; ca. 1480]Title supplied by cataloguer. Six staves per page. The staves are in red ink with square musical notes and the text in black. Decorated initials in red and blue (1 in gilt, green, red & blue). Modern binding in stamped brown leather with leather ties. Description: 1 choir book ([30] leaves), bound : vellum ; 60 cm. 2015-06-05T00:00:00Z RB Add.Ms. 376 Deane http://hdl.handle.net/2123/13209 Title: RB Add.Ms. 376 Deane Abstract: Handwritten antiphonal totally executed on vellum, most probably produced for use in a convent of Hieronymite nuns, under the advocation of Our Lady of the Snows. Text in 5 parts: (I) 48 folios, (II) 29 folios, (III) 29 folios, (IV) 3 folios, (V) 12 folios, some not numbered, containing the proper and ordinary chants asssociated with the different feasts of the Holy Virgin, including that of Our Lady of the Snows, and ending with the chants devoted to Saint Jerome. Decoration of capitals in red, blue and black. Rubricated throughout. Square musical notation on five line staves. Five parts leather bound, raised bands, remains of metallic closures, metallic rims, documentary rear pastedowns, re-backed. Text opens with a dedication: "Este libro dio al Convento, una Esclava de la Virgen Maria y pide humilmente a las Religiosas desta Casa, la encomienden a Dios" (A Virgen slave gave this book to the Convent, and she humbly asks the members of our Order to entrust her to God). Description: 121 leaves, bound : vellum ; 53.5 x 35.5 + writing template 42 x 23.5 cm. 2015-04-21T00:00:00Z RB Add.Ms. 367 http://hdl.handle.net/2123/12481 Title: RB Add.Ms. 367 Abstract: The antiphonary, a song book for use in a liturgical choir in the Roman Catholic liturgy, was mainly used for singing Mass or the canonical Hours (antiphonarium officii). This antiphonary was compiled and written for the use of St. Augustine. Contains the variable (Proper) items from the Office-- antiphons, hymns, responsories. Starts with Vespers Introit Rex pacificus. Description: 1 choir book ([i], 272, [3] p.) : vellum ; 59 cm. Title from bookseller's description. Holograph, written on both sides of leaf. Includes index (last 3 pages). Format of parchment: Gregory's Rule. The text is written in Gothic characters with some in different hands indicating that it was added to over time. Mostly black square notation but some mensurally notated hymns. Both text and music are in black or red with initial letters in blue or red. It contains 24 large illuminated initials in a fine artistic style with vegetable, floral, and zoomorphic (bird) motifs as well as musical instruments and human figures. The state of the leaves vary both to heavy wear and occasional water damage (at the front) and the different quality of the vellum used. Pastedowns are from a different <antiphonary?>. Bound in leather with 2 brass and leather clasps, 8 heavy brass corners (4 each on front and back) and 10 brass bosses (5 each on front and back). 2014-12-16T00:00:00Z RB Add.Ms. 351 http://hdl.handle.net/2123/12272 Title: RB Add.Ms. 351 Abstract: [Spain], ca. 1675. This volume contains multiple settings of several sections of the Mass, including the Asperges, Kyrie, Gloria (including one setting with additional clauses praising the Virgin Mary), Credo and Sanctus. Description: [75] leaves [i.e. 150 p.], bound : vellum ; cover 52cm x 38cm; writing field 40cm x 27cm. [Title supplied by cataloguer.] Bound in contemporary full calf over thick wooden boards with protective brass skids and studs, and with remnants of the original leather ties. Illuminated with musical staves in red, square musical notes in black, text in red and black, and decorated initials in red and blue. 2014-11-13T00:00:00Z RB Add.Ms. 358 http://hdl.handle.net/2123/12251 Title: RB Add.Ms. 358 Abstract: [Spain, ca. 1535-1540] This responsorial contains a remarkable depiction of an American turkey, one of the earliest extant illustrations of American fauna to appear in Europe and certainly the earliest illustration of a turkey. The illustration appears on the verso of the first leaf as part of the border, on the lower left corner. The manuscript contains the responses for feasts, starting with Christmas, which appears on the same leaf as the turkey illustration. It also contains those for the Feast of the Crown of Thorns, a feast mainly celebrated in Spain for which there are few surviving manuscripts. Description: 1 choir book ([66] p.), bound : vellum ; 24cm x 17cm; text 23cm x 16cm. [Title supplied by cataloguer.] With decorated border on verso of first leaf and 26 illuminated initials in liquid gold and green on backgrounds of mauve and blue with white leafy tracery. Text in red and back. Staves ruled in red, musical notes are square & black. Bound in 17th century brown morocco. Spine restored. 2014-11-10T00:00:00Z RB Add.Ms. 380 Deane http://hdl.handle.net/2123/12232 Title: RB Add.Ms. 380 Deane Abstract: "Latin music manuscript for a monastery of the Hieronymites on vellum, complete. Written in Spain probably in or for Guadalupe (a municipality located in Las Villuercas comarca, province of Cáceres, Extremadura) in the first quarter of the 16th century.With four music systems (first page three) on each page with square notes on five red staves (each 16 mm). Numerous initials in red and blue and decorated letters in black. Few later corrections and additions. This Processional contains hyms and liturgy prescribed for processions on feast days. On fol. 92 ff. are hyms in honour of St. Jerome. This indicates, that it was written for the Order of St. Jerome, and- as an ownership entry suggests- for their monastery in Guadalupe." -- Bookseller's description. Description: [Spain : s.n.], 1526, 1568. 105mm x 150mm; text 70mm x 100mm. 1 v., bound : vellum. 2014-11-06T00:00:00Z RB Add.Ms. 327 http://hdl.handle.net/2123/12231 Title: RB Add.Ms. 327 Abstract: Text comprises settings of the Sanctus and Agnus Dei, including 6 pages of polyphonic notation (leaves 25? to 27?, a setting of the Patrem omnipotentem factorem celi) and the offices from Christmas Day to Epiphany, the 12th day of Christmas. Contains an incomplete bifolium as rear paste-down: Catholic Church. Breviary (Ms. University of Sydney. Library. Rare Books and Special Collections Library. Add. Ms. 327). [Breviarum]. [11--]. Description: [15--]. [Title supplied by cataloguer.] Cover 50 x 36cm. Writing field 39 x 25cm. Text on both sides of leaf. Mediaeval manuscript choirbook on vellum; executed 16th century in Spain; massive binding of thick wooden boards covered with tanned leather, ruled in blind and fitted with 5 pierced brass metal bosses to each cover; metal strengthening to corner with metal clasps and catches; binding slightly repaired but very large and impressive; much used with many pages thumbed and worn (some defective and repaired). Gatherings mostly of eight leaves with sideways catchwords; leaf [32] inserted from a slightly smaller copy (ca. 41 x 26 cm.); 7 lines of text in a rounded gothic hand and of music on a five-line red stave, rubric in red, some capitals touched in yellow; many large calligraphic initials throughout, often with elaborate penwork infill in yellow; includes 43 large plain red initials, 102 large black initials in various styles (some celtic), 44 large red and blue initials with penwork infilling and surround, plus 2 similar, but very large and fine, red and blue initials (leaves 2? and 35?). 2014-11-06T00:00:00Z


text: Kenny Chesney's 'American Kids' Video Is Here By Erin Grant June 30, 2014 11:51 AM Share on Facebook Share on Twitter It's finally here! Peace, love, and good times in Kenny Chesney's brand new video for "American Kids".Barefeet, water, hippies, get your groove on! Filed Under: American Kids | kenny chesney Category: What's New Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of WBKR Recommended For You Best of the Web


text: Cornrows in the front hair weave in the back ThirstyRoots 4 Comments 4 Responses khadijahbaby May 8, 2011 I love it Reply felionz January 16, 2012 Beautiful!! and inspiration to get my hair braided!!! Reply Precious February 2, 2012 Definitely inspired to do my own braided hairstyle for Valentine's Day Reply faith December 10, 2012 i love this website it really helps me for picking how i want my hair braided Reply Leave a Reply Cancel Reply Your email address will not be published. Name* Email* Website Comment


text:
Ballston Lake This is a photo gallery of pictures from Saratoga County on Sunday.
Photo Gallery
Irene smashes through Saratoga County
Irene's wind and rain caused widespread damage Sunday in Saratoga County. At the peak, over 30,000 households were without power in the County. Flooding kept officials and local fire departments busy throughout the day.
More like this story
Use the comment form below to begin a discussion about this content.


text:
G Dragon Sandara Park Latest News
Sandara Park and G-Dragon Take a Goofy Shot Together
YG Family's Sandara Park and G-Dragon took a goofy picture together. This was posted through Sandara Park's Twitter on which she also wrote, "GD and Top? No~ GD and San. We took this picture while waiting for our turn to perform at the Osaka Family Concert." . ... Read more
Double Park announces 2NE1's future plans in urgent press conference Latest K-Pop News
Double Park (Sandara Park and Park Bom) held an urgent press conference on November 18 at 9AM (KST) at the YG Cafeteria, where they delivered news about 2NE1's future plans and upcoming songs.. ... Read more
Park Bom vs. Gain, who wore it better? Latest K-Pop News
2NE1's Park Bom and Brown eyed girl's Gain were spotted wearing the same design dress at two different events.
Park Bom wore this Balmain wool slit short dress at 2013 Korea Brand & Entertainment Expo press conference held on October 10 while Gain was at 'Love Your W' charity event held on October 17.
The two girls look attractive and lovely at the same time in this sexy black dress. You think who looks better?
Jenny@dkpopnews . ... Read more
G-Dragon and Jung Hyung Don to continue their bromance on Weekly Idol! Latest K-Pop News
Flirtatious duo G-Dragon and Jung Hyung Don are going to continue their bromance on the special episode of Weekly Idol. From the recent tweet of MBC's Weekly Idol, it has been revealed that G-Dragon recorded the show.. ... Read more
Can G-Dragon fit himself in a utility box? Latest K-Pop News
G-Dragon proves how flexible he is by managing to fit himself inside a utility box. He posted a photo of himself through his twitter account on November 16 while waiting for their concert.. ... Read more
G-Dragon feat. Bom in his Japanese version of 'Black' preview Latest K-Pop News
2NE1's Park Bom will be featured in G-Dragon's Japanese version of 'Black' from his album 'Coup d'État'.
Watch the preview here.... Read more
Jay Park marks his latest tattoo! Yay or Nay? Latest K-Pop News
Jay Park updated his Instagram with a new ink on his hand.
It's his latest tattoo of a king lion, which literally has its own crown. The tattoo gives an illusion that Jay has a hairy hand.. ... Read more
Park Shin Hye remakes Standing Egg's "Goodbye For You, Not For Me" Latest K-Pop News
Actress Park Shin Hye is showing off her singing talent once again by releasing a remake of Standing Egg's "Goodbye For You, Not For Me".
"Goodbye For You, Not For Me" is originally included in Standing Egg's first album With. And being a fan of the band, Park Shin Hye found the time to record one of her favorite songs in between the drama "The Heirs".. ... Read more
[NEWS] 2ne1's Sandara Park fierce female who pulled off shaved head hairstyle
The shaved head in one side may have been a hairstyle which have been pulled off in the past but 2ne1's Dara is a fierce female who pulled it. 2ne1's Sandara Park made headlines with her one side of her hair shaved off for their comeback with their new single "I Love You". Though risky and is a hesitating decision especially for a girl, Dara went on with it with a hesitant heart but later embraced her new hairstyle.. ... Read more
[NEWS] Sandara Park hints at 2NE1 comeback
2NE1's Sandara Park hyped fans after hinting about their possible comeback.
On May 19th, Sandara uploaded an adorable photo of herself and wrote, "Wassup?!? Here is an alert! Okay~ Those of you have been thirsty for 2NE1 up until now~Those who have done many things for us~ Those who have quietly listened to our music and ㅡㅡ+ and Blackjacks who have been cheating on us, gather round!^_^ Now slowly slowly..get together!^.*". ... Read more


text:
"That was a great advance, which showed that gene therapy is safe and lasts for years in humans, but this new study has the potential for a bigger impact, because it is treating a form of the disease that affects many more people," said John G. Flannery, Ph.D., a professor of neurobiology at the University of California, Berkeley who is an expert in the design of viruses for delivering replacement genes. Flannery was not involved in the current study.
The X-linked form of retinitis pigmentosa addressed in the new study is the most common, and is caused by degeneration of light-sensitive cells in the eyes known as photoreceptor cells. It starts early in life, so though affected children are often born seeing, they gradually lose their vision.
"These children often go blind in the second decade of life, which is a very crucial period," said co-author Alfred S. Lewin, Ph.D., a professor in the UF College of Medicine department of molecular genetics and microbiology and a member of the UF Genetics Institute. "This is a compelling reason to try to develop a therapy, because this disease hinders people's ability to fully experience their world."
Both Lewin and Hauswirth are members of UF's Powell Gene Therapy Center.
The UF researchers and colleagues at the University of Pennsylvania performed the technically challenging task of cloning a working copy of the affected gene into a virus that served as a delivery vehicle to transport it to the appropriate part of the eye. They also cloned a genetic "switch" that would turn on the gene once it was in place, so it could start producing a protein needed for the damaged eye cells to function.
After laboratory tests proved successful, the researchers expanded their NIH-funded studies and were able to cure animals in which X-linked retinitis pigmentosa occurs naturally. The injected genes made their way only to the spot
|Contact: Czerne M. Reid
University of Florida


text:
Prior studies have compared the effect of spinal cord injury elicited using distinct approaches on motor and visceral function. However, the impact of such discrete modes of injury specifically on bladder muscle contractility has not been explored in detail. The goal of this study is to compare the impact of complete spinal cord transection versus clip compression at thoracic vertebra eight (T8) on bladder muscle contractility.
Rats underwent no treatment (Control), laminectomy (Sham, SH); complete extradural transection (TX); or cord compression with an aneurysm clip (CX). Bladders and spinal cords were harvested at 6 wk for contractility studies or histological analysis.
Detrusor strips from TX and CX rats showed higher spontaneous activity than those from SH rats. Furthermore, the duration of the neurally-mediated contractile response was longer in TX and CX rats compared to controls and showed attenuated relaxation. No significant differences were observed between muscle strips from SH, TX or CX rats in response to KCl, ATP or phenylephrine. However, tissues from TX and CX rats showed a higher sensitivity to carbachol compared to that from SH animals.
Complete SCI in rats either by cord transection or compression elicits qualitatively similar changes in bladder muscle contractility. Whereas cord transection is arguably easier to perform experimentally, cord compression better models the situation observed clinically, such that each approach has clear advantages and limitations.
Keywords:Bladder; Smooth muscle; Spinal cord injury; Muscle contractility
Spinal cord injury (SCI) is a devastating occurrence, affecting up to 12,000 people annually in the United States (http://www.fscip.org/facts.htm webcite). The cost of lifelong treatment for SCI is significant, running into hundreds of thousands of dollars per affected individual [1,2]. Urologic complications account for much of the morbidity associated with SCI and comprise a significant fraction of the associated cost of treatment and rehabilitation. In addition, bladder dysfunction secondary to SCI or congenital neural defects is a source of considerable psychosocial and physical distress to patients [3].
Experimental SCI can be induced in a variety of ways, including crush injury using a clip or Horizon Impactor apparatus [4,5], complete or partial transection of the cord [6-8] or by occluding blood supply to the cord to elicit ischemic injury [9,10]. Previous reports have compared functional outcomes following a variety of complete and incomplete spinal cord injuries in rodents primarily using cord transection or compression to evoke injury [11,12]. Whereas many parameters relevant to voiding such as bladder capacity, voiding efficiency and micturition cycle time were indistinguishable between complete cord transection and cord compression [11,12], selected aspects of lower urinary tract function were different. In particular, the extent of detrusor-sphincter dyssynergia was lower in rats with compression injury compared to those with cord transection [11]. However, the extent to which these differences are maintained at the level of bladder smooth muscle has not been completely defined. In this study we have employed two modes of thoracic spinal cord injury to test the hypothesis that spinal cord injury following complete transection versus clip compression injury elicits distinct effects on bladder smooth muscle contractility. We have chosen thoracic vertebra 8 (T8) as the site of injury as this emulates the phenotype of an upper motor neuron lesion. Injury at this level interrupts all major efferent and afferent pathways including corticospinal, rubrospinal, vestibulospinal, spinothalamic and spinocerebellar tracts. Such injuries are known to elicit a range of consequences including loss of gross and fine motor function, manifest as hindlimb paralysis and loss of proprioception, as well as visceral dysfunction in the gastrointestinal and urinary tracts. In particular, suprasacral injury is effective in eliciting a phenotype comprising an overactive/reflex bladder.
Creation of spinal cord injury in rats
Thirty three male Sprague–Dawley rats (6 wk of age) were divided into 3 groups of 11: sham-operated rats (SH, laminectomy only); transected rats (TX, complete extradural cord transection at T8); and clip compression rats (CX, cord compression at T8). A fourth cohort of rats received no treatment (Control). Injury at T8 models an upper motor neuron lesion and elicits a reflex bladder phenotype with overactivity. Under general anesthesia induced with ketamine (75 mg/kg, i.p.) and medetomidine (0.5 mg/kg, i.p.), a dorsal midline incision was made over the thoracic spinal cord. Superficial and deep muscle layers were incised in the midline to expose the spine. Sham operated animals underwent laminectomy only, while TX rats received a complete extradural transection at T8. A straight microaneurysm clip (0.8 mm × 5 mm) imparting 60 g closing force (Harvard Apparatus, Harvard, MA) was used to compress the cord at T8 for 60 sec in CX rats. Post-operative pain was managed with meloxicam (1 mg/kg, i.p.) analgesia. During the period of spinal shock, which lasted from 1-3 wk following creation of SCI, bladders of rats were emptied twice daily by manual compression with care taken to avoid unintentional bladder rupture. Six weeks following creation of SCI, bladders were harvested for endpoint evaluation. All bladders were weighed and either placed in Hank's balanced salt solution for 15 min prior to fixation in neutral-buffered formalin for histological analysis, embedded in O.C.T for molecular evaluation or processed for contractility testing as outlined below. All animal studies were approved by the Boston Children's Hospital Animal Care and Use Committee prior to experimentation.
Ex-vivo contractility assay
At 6 wk after SCI, bladders from 5 rats in each cohort were harvested and preserved in ice-cold Kreb's buffer (NaCl 120 mM; KCl 5.9 mM; NaHCO3 25 mM; Na2H2PO4 1.2 mM; MgCl • 6H2O 1.2 mM; CaCl2 2.5 mM; dextrose 11.5 mM) for ex vivo contractility analyses. Bladder tissue was carefully cut into strips and the mucosa dissected off the detrusor muscle under microscopic guidance. Detrusor strips were suspended in an organ bath maintained at 37°C and bubbled with a mixture of 95% O2 and 5% CO2. Tissues were attached to a force transducer (Grass Instruments), stretched to a resting tension of 1.5 g and equilibrated for 45 min. Contractile responses to phenylephrine (adrenergic agonist, 100 μM), carbachol (cholinergic agonist, 1 nM-10 μM), α,β-methylene-ATP (purinergic agonist, 10 μM), KCl (120 mM), and to electrical field stimulation (1-64 Hz, 20 V, 0.5 ms pulse width, 10 sec duration) were measured in separate strips. Conditioned signals from force transducers were continuously acquired at 30 Hz by a 16-channel analog-to-digital converter (DataQ, DI-720) and recorded to disk using Windaq data acquisition software. Data were expressed as force (mN) normalized by tissue cross-sectional area and presented as mean ± SEM. The area under the curve of EFS-induced contractions was calculated at each frequency as the integral of force over the time interval from the beginning of stimulation to the return to 10% of the maximum contraction.
Characterizing the pattern of spontaneous activity by conventional methods that quantify the amplitude and frequency of oscillations can be challenging, particularly after SCI. Therefore, spontaneous activity of muscle strips was assessed in the frequency domain by discrete Fourier transformation (DFT), as described [13]. A time series of 4.5 min (8191 data points) was selected for analysis from data acquired under resting conditions prior to the stimulation protocols above. The power spectrum generated from the DFT was smoothed using a moving average filter (Windaq waveform analysis software). The power spectrum describes the strength of oscillations as a function of frequency and peaks in the spectra identify the predominant frequencies composing the spontaneous activity signal. These peaks were detected as local maxima and the corresponding frequency at which the peaks occurred was recorded for each tissue strip. Power was expressed in decibels as the log transformed relative magnitude of spontaneous oscillations.
Catheter placement and awake unrestrained cystometry
Five wk after surgery, a suprapubic (SP) catheter was inserted in up to 8 rats in each cohort and tunneled under the skin to the back of the neck. Cystometry was conducted 1-3 d after SP catheter placement. The SP catheter was attached to a physiological pressure transducer (MLT844 AD Instruments) to allow measurement of intravesical pressure, while bladder was continuously infused with sterile PBS at 100 μl/min. Pressure readings were converted to digital signals using a PowerLab data acquisition system and analyzed using LabChart Pro software (ADInstruments, Colorado Springs, CO). Post void residual volumes were measured by aspirating the SP catheter at the conclusion of cystometry. A spontaneous non-voiding contraction (SNVC) was defined as any rise in intravesical pressure of greater than 5 cm H2O.
Statistical analysis
Analysis of contractility data was conducted using analysis of variance (ANOVA) followed by Holm-Sidak or Dunn's post-hoc analysis for normally and non-normally distributed data respectively. Normality was determined by Shapiro-Wilk tests. SigmaStat was used to carry out statistical analyses.
Histologic characterization of spinal cords and bladders in injured rats
To compare the nature and extent of injury in rats exposed to different types of spinal insult, we performed histologic analysis of bladders and spinal cords from each cohort of rats. Consistent with previous reports in the literature [14], the bladder-to-body weight ratios in TX and CX rats were significantly higher than in SH animals, as a result of increased bladder weights following SCI (*, p < 0.05 in each case, Figure 1A). Compared to bladders of sham-operated rats that received laminectomy only, bladders from animals with compression or transection injury showed a marked increase in size (Figure 1B). Although specimens from rats with transection injury showed a greater variation in bladder-to-body weight ratio than those from rats with compression injury, there was no significant difference in bladder wall appearance in each case. In contrast to cords from SH animals, sagittal sections of cords obtained from TX and CX rats displayed variable amounts of foamy cells occupying areas of cavitation (Figure 2H). The cavities were frequently larger and completely formed in CX rats and displayed features of pseudocysts (Figure 2C, 2F). In contrast, cavities were more disorganized and smaller in the TX rats and were more frequently surrounded by a glial scar. The presence of edema, necrosis, and fibrosis appeared to correlate with the extent of the injury. Neuronal damage, consisting of neuronal swelling and chromatin dispersion with focal chromatolysis, was particularly severe in close proximity to the lesion in both TX and CX rats.
Figure 1. Comparable remodeling of the bladder wall in spinal cord injured rats compared to controls. (A) Bladder-to-body weight ratios were calculated from non-operated controls (n = 4), laminectomy (Sham, n = 4), spinal cord transection (Transection, n = 4) or spinal cord clip compression (Clip, n = 5) groups. (B) H&E-stained bladder wall sections at low (a-d) and high (e-h) magnification are shown. Scale bars: a-d, 100 μm; e-h, 10 μm.
Figure 2. Distinct histological changes in spinal cord sections from sham and injured rats. Spinal cords from sham (A, D, G), transected (B, E, H) or clip compression (C, F, I) rats were harvested at 6 wk post injury and stained with H&E. Scale bars = 5 mm (A, B, C); 100 μm (D, E, F); 20 μm (G, H, I). Arrowheads in (C) indicate pseudocysts that form within the cord following injury. The dotted line in (H) indicates an area enriched with foamy cells (F).
Voiding behavior in spinalized rats
Routine evaluation of rats revealed a return of voiding activity 2–3 wk after injury, indicating the end of the spinal shock period. Consistent with previous reports, voided volumes in SCI rats were larger than those in SH controls following injury. At wk 3, mean voided volumes in TX and CX were 2.63 ± 0.84 ml and 2.50 ± 0.86 ml respectively, which were significantly higher than mean voided volume in SH of 1.40 ± 0.64 ml; at wk 5, mean voided volumes in TX and CX were 2.76 ± 0.86 ml and 2.27 ± 0.61 ml, respectively compared to 1.32 ± 0.67 ml in SH rats. At each time point, differences in voided volumes between spinal cord injured animals and sham rats were statistically significant (TX vs SH, p < 0.05; CX vs SH, p < 0.05). However, no significant difference was observed in voided volumes between TX and CX rats.
Cystometric analyses in conscious animals revealed variable degrees of bladder overactivity in both TX and CX rats, that was not observed in SH animals. Spontaneous non-voiding contractions (SNVCs) were seen consistently during each filling phase in 7 of 8 TX rats, 6 of 7 CX rats, but in 0 of 7 SH rats. The mean number of SNVCs per voiding cycle in the TX and CX groups were 3.6 and 3.9 respectively, compared to SH rats, which had a mean SNVC frequency of <1 per voiding cycle. Although spinalized rats had significantly greater overactivity compared to controls, no difference in this parameter was observed between TX and CX animals.
Ex vivo contractility analysis
To investigate potential mechanisms underlying the altered voiding behavior observed following SCI, we performed contractility analyses on isolated bladder muscle strips. We observed significantly higher amplitude spontaneous activity in bladder tissue from both TX and CX rats compared to SH controls. The irregular amplitude and frequency of spontaneous activity observed in SH rats contrasted sharply with the uniform spontaneous oscillations in injured animals that were more organized and complex. This altered pattern of activity is illustrated in Figure 3, which shows low frequency, high power events in all groups; however, the power spectral peak was significantly higher and the frequency was lower in the injured groups (p < 0.05). The mid-frequency component of spontaneous activity was shifted to significantly higher frequencies in injured animals, although the power spectral peaks at these frequencies were not different from non-injured animals. Interestingly, a high frequency/low power component of spontaneous activity emerged only in tissues from injured animals (Figure 3B).
Figure 3. Increased spontaneous activity in bladder strips from injured rats versus controls. (A) Representative tracings of spontaneous activity in bladder tissue from control, TX and CX rats. (B) Comparison of relative magnitudes at corresponding frequencies determined from power spectra of spontaneous activity in each group (*significantly higher power and lower frequency than control, p < 0.05; # significantly higher frequency than control, p < 0.05).
Upon evaluation of agonist-induced alterations in muscle contractility, there was no significant difference noted in tension generation in response to KCl, α,β-me-ATP or phenylephrine (PE) between tissues from SH, TX or CX rats (Figure 4A - C). However, muscle strips from spinalized rats were more sensitive to carbachol, a cholinergic agonist and parasympathomimetic agent (Figure 5A). The half maximal effective concentration (EC50) of carbachol was significantly lower in muscle strips from injured rats than in control rats (p < 0.05, Figure 5B). Although the contractile response was significantly lower in control animals at low carbachol concentrations, the maximum response was not different among groups.
Figure 4. Comparable ex vivo contractility of detrusor tissue strips from rats with transection versus compression injury. Contractile responses to (A) increased extracellular KCl (120 mM), (B) α-β-me-ATP (10 μM) and (C) phenylephrine (100 μM) in control, TX and CX bladders.
Figure 5. Enhanced cholinergic sensitivity in detrusor tissue strips from injured rats versus controls. (A) Dose–response curves for carbachol in control, TX and CX bladders. *, control significantly lower than TX and CX, p < 0.05. (B) EC50 values generated from concentration-dependent carbachol contractions in bladder tissue from control, TX and CX. *, significantly lower than control, p < 0.05. (C) Original representative tracings from each group showing contractile responses to EFS at a frequency of 1 Hz. Stimulation began at 10 sec and terminated at 20 sec. Data represent mean ± SEM. (D) Frequency-response curves for EFS expressed as area of contraction. *, significantly lower than TX and CX, p < 0.05; #, significantly lower than TX, p < 0.05.
The frequency-response curves generated by EFS in both SCI groups were not different from controls. While the maximum amplitude of contraction was similar among groups, the time course of the contractile response was markedly altered in injured animals, with prolonged duration of contraction and attenuated relaxation (Figure 5C). Consequently, the area of the EFS-induced responses was greater in TX and CX rats, particularly at lower frequencies of stimulation (Figure 5D).
Previous reports comparing the effect of complete and incomplete SCI by cord transection or compression, respectively, on lower tract function have yielded somewhat different results [11,12]. Using a weight drop contusion model of SCI versus complete cord transection, Pikov and colleagues demonstrated some restoration of coordinated voiding behavior within 2 wk of injury in rats with cord contusion, that was not observed in rats with cord transection [11]. In a related study, larger expressed bladder volumes were noted in rats with spinal cord transection, compared to animals with incomplete cord injury [12], suggesting that injury severity is a key variable in dictating restoration of function. In our study, both spinal cord compression and transection evoked complete injury, in agreement with the comparable functional outcomes in tissue remodeling, voiding behavior and muscle strip contractility.
In organ bath studies, we observed significantly higher spontaneous activity of bladder muscle strips from injured rats compared to controls. Previous studies suggest that SCI causes the re-emergence of a neonatal pattern of spontaneous activity [15]. During early postnatal development, large amplitude/low frequency activity has been described [16], similar to the activity observed in our injured animals. Developmental changes examined by Fourier analysis previously demonstrated a low frequency component (0.08-0.21 Hz) that emerged after a few weeks of age and a second component (~0.5 Hz) that arose after 3 wk of age. After 5 wk of age, the magnitude of the low frequency component was reduced while the second component was predominant. These data are consistent with the frequency spectra that we detected in adult control animals and the shift to higher magnitude at low frequency after injury corresponding to the postnatal pattern. However, the complexity in the pattern of activity was greater in SCI, as evidenced by higher frequency components in the power spectra that became apparent after SCI but were absent in non-injured and neonatal animals [16].
Among the stimulus-evoked responses in muscle strips, significant differences were observed in the SCI groups in response to EFS and carbachol. An increase in acetylcholine release from nerve terminals has been previously reported after SCI due to a shift from pre-junctional M1 muscarinic receptor-mediated facilitation of neurotransmission to high affinity M3 receptor activated release of acetylcholine [17]. This change in pre-junctional regulation of cholinergic neurotransmission may underlie the augmented duration of the contractile response to EFS in TX and CX rats. The increased sensitivity of muscle strips from SCI rats to carbachol, without a change in the contractile response to KCl, suggests dysregulation of post-synaptic muscarinic receptor signaling. Although cholinergic contractile responses are normally mediated by the M3 muscarinic receptor subtype, alterations in M2 receptor signaling in smooth muscle have been reported post-SCI. In the rat, SCI enhanced the response to a M2 receptor agonist and increased M2 receptor gene expression [18], suggesting an augmented contribution from M2 receptor signaling to cholinergic contraction in SCI bladders. A similar shift from M3 to M2 receptor mediated contraction has been described in patients with neurogenic bladder [19].
In summary, both transection and clip compression models of SCI provide similar, reproducible changes in several parameters relevant to lower urinary tract function. Whereas cord transection is arguably easier to perform experimentally, cord compression better models the situation observed clinically, such that each approach has clear advantages and limitations. These studies provide a basis for subsequent investigations into agents that may target the deleterious consequences of SCI.
ANOVA: Analysis of variance; CX: Spinal cord compression; EFS: Electrical field stimulation; i p: Intraperitoneal; KCl: Potassium chloride; O C T: Optimal cutting temperature compound; SCI: Spinal cord injury; SH: Sham-operated; TX: Spinal cord transection.
Competing interests
The authors declare they have no competing interests.
Authors' contributions
AS, MPS and RMA conceived of the study; AS, YGC, DK, AR, PG and DT performed spinal cord surgeries, post-operative management of rats, tissue harvesting and preparation of tissue for histological analysis; LH, VC and MPS performed statistical analysis; LIB consulted on creation of spinal cord injury; DDV performed histopathological analysis of tissues; AS, MPS and RMA wrote the manuscript. All authors read and approved of the final manuscript.
The authors would like to thank members of the Urological Diseases Research Center at Boston Children's Hospital for helpful discussions, as well as Dr. Peter Zvara and colleagues at the University of Vermont for their help in optimizing functional analysis in rodents. The authors acknowledge financial support from the Children's Urological Foundation and from the National Institutes of Health (R01 DK077195 and P50 DK65298 to R.M.A.; R00 CA131472 to D.D.V.) and the Medical Research Service, Department of Veterans Affairs (M.P.S).
Berkowitz M, O'Leary P, Kruse D, Harvey C: Spinal Cord Injury: An Analysis of Medical and Social Costs. New York: Demos Medical Publishing, Inc.; 1998.
Priebe MM, Chiodo AE, Scelza WM, Kirshblum SC, Wuermser LA, Ho CH: Spinal cord injury medicine. 6. Economic and societal issues in spinal cord injury.
Anderson KD: Targeting recovery: priorities of the spinal cord-injured population.
J Neurotrauma 2004, 21(10):1371-1383. PubMed Abstract | Publisher Full Text
Zeman RJ, Wen X, Ouyang N, Rocchio R, Shih L, Alfieri A, Moorthy C, Etlinger JD: Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats.
Neurosurgery 2008, 63(5):981-987.
discussion 987–988PubMed Abstract | Publisher Full Text
Ito Z, Sakamoto K, Imagama S, Matsuyama Y, Zhang H, Hirano K, Ando K, Yamashita T, Ishiguro N, Kadomatsu K: N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury.
J Neurosci 2010, 30(17):5937-5947. PubMed Abstract | Publisher Full Text
Norreel JC, Pflieger JF, Pearlstein E, Simeoni-Alias J, Clarac F, Vinay L: Reversible disorganization of the locomotor pattern after neonatal spinal cord transection in the rat.
J Neurosci 2003, 23(5):1924-1932. PubMed Abstract | Publisher Full Text
Sadlaoud K, Tazerart S, Brocard C, Jean-Xavier C, Portalier P, Brocard F, Vinay L, Bras H: Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury.
J Neurosci 2010, 30(9):3358-3369. PubMed Abstract | Publisher Full Text
King VR, Alovskaya A, Wei DY, Brown RA, Priestley JV: The use of injectable forms of fibrin and fibronectin to support axonal ingrowth after spinal cord injury.
Biomaterials 2010, 31(15):4447-4456. PubMed Abstract | Publisher Full Text
Zhou Y, Zhao YN, Yang EB, Ling EA, Wang Y, Hassouna MM, Mack P: Induction of neuronal and inducible nitric oxide synthase in the motoneurons of spinal cord following transient abdominal aorta occlusion in rats.
J Surg Res 1999, 87(2):185-193. PubMed Abstract | Publisher Full Text
Lu K, Liang CL, Liliang PC, Yang CH, Cho CL, Weng HC, Tsai YD, Wang KW, Chen HJ: Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms.
J Neurochem 2010, 114(1):237-246. PubMed Abstract | Publisher Full Text
Pikov V, Gillis RA, Jasmin L, Wrathall JR: Assessment of lower urinary tract functional deficit in rats with contusive spinal cord injury.
J Neurotrauma 1998, 15(5):375-386. PubMed Abstract | Publisher Full Text
Leung PY, Johnson CS, Wrathall JR: Comparison of the effects of complete and incomplete spinal cord injury on lower urinary tract function as evaluated in unanesthetized rats.
Exp Neurol 2007, 208(1):80-91. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Diaz M: Application of Fourier linear spectral analyses to the characterization of smooth muscle contractile signals.
J Biochem Biophys Methods 2007, 70(5):803-808. PubMed Abstract | Publisher Full Text
Kruse MN, Bray LA, De Groat WC: Influence of spinal cord injury on the morphology of bladder afferent and efferent neurons.
J Auton Nerv Syst 1995, 54(3):215-224. PubMed Abstract | Publisher Full Text
Artim DE, Kullmann FA, Daugherty SL, Bupp E, Edwards CL, De Groat WC: Developmental and spinal cord injury-induced changes in nitric oxide-mediated inhibition in rat urinary bladder.
Neurourol Urodyn 2011, 30(8):1666-1674. PubMed Abstract | Publisher Full Text
Szell EA, Somogyi GT, De Groat WC, Szigeti GP: Developmental changes in spontaneous smooth muscle activity in the neonatal rat urinary bladder.
Am J Physiol Regul Integr Comp Physiol 2003, 285(4):R809-R816. PubMed Abstract | Publisher Full Text
Somogyi GT, Zernova GV, Yoshiyama M, Rocha JN, Smith CP, De Groat WC: Change in muscarinic modulation of transmitter release in the rat urinary bladder after spinal cord injury.
Neurochem Int 2003, 43(1):73-77. PubMed Abstract | Publisher Full Text
Gevaert T, Owsianik G, Hutchings G, Van Leuven L, Everaerts W, Nilius B, De Ridder D: The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity.
Eur Urol 2009, 56(1):168-176. PubMed Abstract | Publisher Full Text
Pontari MA, Braverman AS, Ruggieri MR Sr: The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction.
Am J Physiol Regul Integr Comp Physiol 2004, 286(5):R874-R880. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
You can reach your stuff on the truck bed thanks to the part called the tailgate, and more importantly the tailgate handle. This tailgate handle comes with a bezel, a component that attaches the handle to the tailgate itself. Although it's built tough, your tailgate handle bezel can wear and get damaged over continuous usage. That is why it's a must to choose a high-quality bezel for your truck. To help you choose which brand to trust, here's what we have to say about the Replacement tailgate handle bezel:
Replacement tailgate handle bezel features:
- Sold individually
- Offered in a black finish
- Made from tough plastic material
- Available as an OE replacement
- Crafted using top-grade materials only
- Features easy installation
- Comes with smooth front and back surfaces
- Covered by a one-year unlimited-mileage warranty
We tried the Replacement tailgate handle bezel on our 2012 Ford F-150, and we've observed the following good and bad points:
The good
- The installation is quick and easy; you just have to get some handy tools and allot an hour to complete the installation.
- You don't have to worry about the component's fitting, since this product directly replaces your stock tailgate handle bezel.
- It's durable so you can expect a longer service life compared to standard bezels.
- It adds style to our 2012 F-150's overall tailgate appearance; the bezel's black finish allows you to match it to any vehicle color you may have.
- It's compatible with our truck's factory parts so we didn't have to buy new components to go with the new tailgate handle bezel.
- You can enjoy having peace of mind, knowing that Replacement has got your back in the event of a factory defect.
- It's more affordable compared to other tailgate handle bezel brands such as Bolton Premiere and Putco.
The bad
- It would've been better if the warranty period is extended to more than a year, but 12 months isn't so bad.
- It's offered in black color only, so you don't have much choice when it comes to the bezel's finish.
The conclusion
The Replacement tailgate handle bezel offers remarkable features such as its durability and easy-install structure. It brings you convenience especially in terms of completing the replacement procedure, allowing you to save bucks from seeking professional help. What makes it more interesting is the fact that this component comes sleek and stylish. Though it's available in black color only, it still gives your vehicle an instant style boost. So if you're into a product that's functional and stylish at the same time, then we recommend the Replacement tailgate handle bezel.


text:
Activists Rally In San Francisco On Anniversary Of Tibetan Uprising
Protestors pray during a demonstration outside of the Chinese... News PhotoCalifornia,Consulate,Horizontal,Politics,Praying,Protest,Protestor,San Francisco - California,USAPhotographer Justin SullivanCollection: Getty Images News 2014 Getty ImagesSAN FRANCISCO, CA - MARCH 10: Protestors pray during a demonstration outside of the Chinese consulate on March 10, 2014 in San Francisco, California. Hundreds of activists marked the 55th anniversary of the 1959 Tibetan uprising and the fifth anniversary of Tibetan self-immolation protests in Tibet. (Photo by Justin Sullivan/Getty Images)


text:
Until then, CPSC chair Inez Tenebaum told reporters, the warning "is a way for us to communicate directly and quickly with consumers."
Tenebaum noted that Wednesday's action is the latest step taken as part of CPSC's "Safe Sleep" initiative, a national campaign designed to educate parents about federal safety standards for cribs and potential bedding hazards.
Sharfstein explained that infant sleep positioners first came to the U.S. market in the 1980s, as a sleep aid that promised to help reduce infant gastroesophageal reflux disease (GERD), as well as the risk for "plagiocephaly."
Also known as "flat head syndrome," plagiocephaly occurs when a baby develops a flat spot or an asymmetrical head shape in response to external pressure. The immobility promised by a sleep positioner was advertised as a way to prevent the type of infant movement that could cause such a complication.
But many parents have turned to the device because of suggestions that by keeping infants on their backs sleep positioners actually reduced the risk of SIDS.
Sharfstein stressed that "the FDA has never approved an infant sleeper to prevent SIDS."
Dr. Rachel Moon, chair of the Sudden Infant Death Syndrome Task Force with the American Academy of Pediatrics, told reporters that, as a pediatrician and a parent, she understands the impetus to place an infant in a positioner if there is some inkling that it might prevent SIDS.
But she was adamant that there was "no scientific evidence" to support such a claim, while mounting indications strongly suggest that positioner devices actually threaten babies with "at least a risk of injury and even a risk of death."
"To me," she said, "the
|Copyright©2010 ScoutNews,LLC.
All rights reserved


text: Regarding "Court says man can sue over 'rain god' tags" (News, June 12): The image of an Indian on our Oklahoma car tags is a proper one to represent the state. Indians maintained a stewardship over this great state before it was a state. Indians deserve the recognition. Doesn't Keith Cressman have something better to do than waste the court's time and taxpayer money on a lawsuit? If he doesn't like the image on the standard tag, he should buy himself a personalized tag.


text:
Dave Scott
92.3 KGON, Portland's Classic Rock Station
KGON Facebook
Listen Live
Audio Vault
Listen On Your Phone
Photo Gallery
Iris Harrison's Blog
Glo Blog
Dave Scott
Bill Prescott
KGON Concert Calendar
KGON Club Calendar
KGON Events
Community Events
KGON'Sider- Amy
Hooter's Bikini Contest
by Amy Linford
posted Apr 22 2013 10:09AM
Is it bad that I'm really looking forward to tonight?
Is it bad that if one of them falls down on the runway, while I will run to help them up and be overly concerned, I might be giggling as well?
Where else can you watch a video with the phrases "butt glue" and "vaseline on your teeth and gums"?
These ladies are very lovely. I just wish Iris was going with me tonight. We'd have a blast. I'm also thankful that I was smart enough to say no to the hosting job.
Is it bad that I'll be eating wings and drinking beer and will never look that good in a bikini? I can answer that one...HELL NO!
Yay Hooter's Bikini Contest tonight at 10pm at the Jantzen Beach Hooter's!
Tags :
Topics :
Back To Blog
<< Previous Post
Next Post >>
Hooter's Bikini Contest
Please Enter Your Comments Below
Title :
Comment :
Please enter the text as it is shown in the box below :
Refresh Image
KGON iPhone App
KGON Text-aholic
KGON Half-Off-Deals!
Follow KGON!
Want a KGON t-shirt?
advertise with us
Recent Blog Posts
Roger McGuinn of The Byrds
Dave Scott
Oct 1
Pat Travers
Dave Scott
Sep 4
Things to do August 28-30
Alicia Steinbeck
Aug 27
Larry the Cable Guy
Dave Scott
Aug 27
Jeff Foxworthy
Dave Scott
Aug 19
Things to do in Portland August 15-16
Alicia Steinbeck
Aug 14
Guitarist Gary Hoey
Dave Scott
Aug 4
Winger's Kip Winger
Dave Scott
Jul 29
Oct 2015
Sep 2015
Aug 2015
Jul 2015
Jun 2015
May 2015


text:
Top-ranked recipe named "Linguini with Caper, Red Pepper and Kalamata Sauce"
Combine all ingredients in a medium sauce pan and simmer for at least one hour (the longer the better!). While sauce is simmering, boil Linguini according to package directions. Serve sauce over the pasta and enjoy!
|My private notes
There are no reviews yet for Linguini with Caper, Red Pepper and Kalamata Sauce. Be the first to review it!
Get the free BigOven app on your phone.
Quickly find any recipe anywhere!
There are no reviews yet. Be the first!


text:
Remove Ads x
Racionais Mc's - A Lua Cheia - download at 4shared. Racionais Mc's - A Lua Cheia is hosted at free file sharing service 4shared.
Share Add to my account
Is owner
View only
Upload & Edit
Members may only view items in this folder.
Members may view, add, edit and delete items in this folder.
McAfee detected a threat in this file:RDN/PWS-Banker.dldr!g trojan
0 comments Add new comment
Wrong code entered. Please, try again.
Enter the code above to post message:
Remove Ads x
Racionais Mc's - A Lua Cheia.zipFile QR Code
More files...


text:
Beacon Press, 2010 - Social Science - 204 pages
Professor Gail Dines has written about and researched the porn industry for over two decades. She attends industry conferences, interviews producers and performers, and speaks to hundreds of men and women each year about their experience with porn. Students and educators describe her work as "life changing."
In Pornland—the culmination of her life's work—Dines takes an unflinching look at porn and its affect on our lives. Astonishingly, the average age of first viewing porn is now 11.5 years for boys, and with the advent of the Internet, it's no surprise that young people are consuming more porn than ever. But, as Dines shows, today's porn is strikingly different from yesterday's Playboy. As porn culture has become absorbed into pop culture, a new wave of entrepreneurs are creating porn that is even more hard-core, violent, sexist, and racist. To differentiate their products in a glutted market, producers have created profitable niche products—like teen sex, torture porn, and gonzo—in order to entice a generation of desensitized users.
Going from the backstreets to Wall Street, Dines traces the extensive money trail behind this multibillion-dollar industry—one that reaps more profits than the film and music industries combined. Like Big Tobacco—with its powerful lobbying groups and sophisticated business practices—porn companies don't simply sell products. Rather they influence legislators, partner with mainstream media, and develop new technologies like streaming video for cell phones. Proving that this assembly line of content is actually limiting our sexual freedom, Dines argues that porn's omnipresence has become a public health concern we can no longer ignore.
Going from the backstreets to Wall Street, Dines reveals how porn is affecting our lives and why its omnipresence is detrimental to our sexual freedom.
What people are saying - Write a review
User ratings
|5 stars
|4 stars
|3 stars
|2 stars
|1 star
LibraryThing ReviewUser Review - pixelette - LibraryThing
Industrial analysis was good. She did leave a lot of her commentary unsubstantiated where I think it probably could have been—perhaps I was expecting a more academic text. She does a good job of ... Read full review
Review: Pornland: How Porn Has Hijacked Our SexualityUser Review - Victoria - Goodreads
This is so scary, the effects of porn on both men and women. But the work is important. Dines' research is thorough, and she makes no qualms about being explicit about what exactly is in the porn. So ... Read full review


text:
I use a lot of cameras without meters and I use the sunny 16 rule frequently, although I usually find it to be more like sunny 11 or sunny 13. It has to be pretty bright to go all the way to f16.
I even find it extremely handy when I am using a camera with a meter. I commonly look at the scene and the light, decide what I want my exposure settings to be, and then check the metering in the viewfinder to see if the camera agrees with me. I frequently go with my own settings even if the camera doesn't totally agree and I am rarely wrong on my exposures. My compositions are frequently screwed up, but the exposure usually comes out pretty good.