text:
Skier mainly but started indoor climbing a couple of years ago. Been outdoors for about 3 years now and the more I do the more I enjoy it: it just gets better and better with every route I do.
ML and SPA trained and looking to get experience before my assessments.
Chippenham, Wiltshire
Best Climbing Experience
The Blanca with John
Argentina with Johnny
The Zoo with Jon
North Wales in the rain with Rupert
Favourite Climbing-Related Discussion Topic
Training, grades, route names. And gear, of course.
Recent Postings
- No posts in last 30 days
UKC Volunteer
Moderator for 4 crags, checking missing climbs added to the logbooks: Aconcagua, Fitz Roy, Volcan del Viento, Cerro Medusa
Interests Outside Climbing
Skiing, dogs, politics, photography
About My Photography
It is amazing.
Photo Gallery
Click to view squicky's gallery. (24 photos)
Click to search for photos of climbers called squicky.
Click to list photo comments written by me. (5 comments)
I've voted for 54 photos, average vote 4.7.
(79% superb - 14% good - 3% average - 1% poor - 0% rubbish)


text:
News & events
Home / News & events
A representative from Becker Professional Education will be on campus to promote a CPA study course for accounting students to prepare them for the CPA exam.
© 2015
Northwestern College. All rights reserved. 712-707-7000. 101 7th Street SW, Orange
City, Iowa 51041
Privacy policy | Feedback

subset: commoncrawl


text:
Comment guidelines: Please be respectful to other people when making comments on this page. Bullying and abuse will not be tolerated and may result in your account being banned. Due to feedback from our user community, comments are now only available to registered users.
Kali Yug: Goddess of Vengeance (Italian: Kali Yug, la dea della vendetta and also known as Vengeance of Kali) is a 1963 Italian fantasy film directed by Mario Camerini and starring Paul Guers.
List of links to Kali Yug, la dea della vendetta fansites:
Register to update information, save favorites, post photos, news stories and comments.


text:
Adopt Hollister, get Harley free
The Humane Society is offering several pairs of "adopt one, get one free" cats in June. This is Hollister, a 1-year-old who came in with his brother Harley. Both are neutered and should live inside only. You can meet Hollister and Harley at the Humane Society of Ventura County in Ojai. Their adoption fee of $120 includes shots, vet check, Humane Society membership, microchip implantation and the love of two wonderful cats. For more information visit http://www.humanesocietyvc.org or call 656-5031. Courtesy photo
Subscribe to the Ventura County Star
Ready to subscribe to the Ventura County Star? Choose between a Premium or Digital subscription below.
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
International Congress on Palliative Care is a premier conference dedicated to palliative care. The conference brings together foremost experts and thought leaders of the field to discuss the current issues related to palliative care. The venue for the conference is chosen to be Montreal, Canada which is absolutely awesome in autumn and thus will provide the right setting for in depth reflection on the themes discussed at the conference. International Congress on Palliative Care will focus on the pediatric palliative care, underlining the crucial importance of it for young lives. The conference claims that the attendees will return with greater vigor and dedication towards palliative care.
Visitors Attending
Aditya Manna
Palliative Care at Mas Clinic & Hospital
Tamluk, India
Lwere Ashiraf Ishaq
Consultant at Kamcare Ltd
Kampala, Uganda
Alex Al Khoury
Montreal, Canada
Facturation Mu00e9dicale L S
President at Facturation Mu00e9dicale L S
5147984895, Canada
Dare Oluwatayo Abraham
Donetsk, Ukraine
Rashidat Abimbola Abimaje
Principal Nursing Officer at Ahmadu Bello University Teaching Hospital
Zaria, Nigeria
Map & Directions
Palais des Congres de Montreal
Montreal, Canada


text:
The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
all the expressive, creative, and inspirational personalities of our community!
Love you too!
Your email has been sent!
In any setting, worn with any ensemble, this darling necklace can always be counted on to cause a 'hoot' and a holler! Featuring onyx-eyed owls, both big and small, strung on a brass-hued chain, this beauty of a bauble is the hit of any party, and adds some instant retro flair to your work wear. Amp up the adorable by pairing this plucky piece with a bird-print dress, peacock-feather tights, and pumps of robin's egg blue for an ensemble that fashion fans are sure to flock to, no matter where you wear it!
Final Sale: This item cannot be returned or exchanged.
Sorry this item isn't available anymore
Remarkable fashion & decor, inspired by our community, & delivered with uncommon care.
Copyright ©2002-2015 ModCloth.com. All Rights Reserved.
Site Map
CA Notice
Privacy & Security
Terms of Use


text:
Before anyone misinterprets this post, let me say that I am not a Satanist. However, I freely admit that I find the Satanic Temple quite interesting and worthy of further investigation on my part, and that I have absolutely enjoyed the recent antics of the Satanic Temple that have passively attacked the many in the US who would so quickly abandon the separation of church and state. I refer to their campaigns, such as those to erect a statue of Baphomet on public grounds next to the monument to the ten commandments in Oklahoma City, and the handing out of a delightful satanic activity book for kids where groups like the Gideons are handing out religious pamphlets in schools.
I embrace this sort of thing. As a Canadian, we don't actually have that separation of church and state thing, but I wish we did. Religion should not create public policy, it should based on a rational interpretation of what is best for society.
I had a thought just now, and I just hope it happens. I would like to see a business put up a sign that said it would not serve Christians. In Arizona, a law was passed to allow business owners to refuse service to gay and lesbian people, so long as they do so for religious reasons. This law was, I believe, vetoed by the Governor, but it mirrors many other laws such as Michigan's House Bill 5958, which may open the door to legally protected discrimination in the name of faith. I say may because, as the link points out, it's Continue reading


text:
Analysis: American Pop
Inexact title. See the list below. We don't have an article named Analysis/AmericanPop, exactly. We do have:
- Awesome/American Pop
- Main/American Pop
- Trivia/American Pop
- WesternAnimation/American Pop
- YMMV/American Pop
If you meant one of those, just click and go. If you want to start a Analysis/AmericanPop page, just click the edit button above. Be careful, though, the only things that go in the Main namespace are tropes. Don't put in redirects for shows, books, etc.. Use the right namespace for those.


text:
I happened to go through the .net framework source code and happened to run across the explicit operator implementation for the Nullable struct implementation. The below screenshots show the implementation of Value property and also the implementation of explicit operator. I also understand that explicit operator is trying to convert from Nullable to T. My question is why is it not that the following code is not throwing an exception
Framework implementation
public T Value {
get {
if (!HasValue) {
return value;
public static explicit operator T(Nullable<T> value) {
return value.Value;
Custome code
int? i = null;
int? i2 = (int?)i; //No Error
int? i = null;
int i2 = (int)i; //Runtime error
It says value.Value and ideally since HasValue will be false (since I assigned null) it should throw invalid operation exception but it happily assigns the value to i2. However instead of (int?)i if we change it to (int)i the InvalidOperatorException from Value property is being raised. My thought was when value.Value is called it will throw an exception because that property is being accessed and it will do its job.
Please clarify on the same
Sai Pavan


text:
NEW YORK (MarketWatch) -- The U.S. dollar accelerated its losses against most other major currencies Thursday, with the dollar index DXY, -0.43% falling 1.1% to 83.74 after the latest batch of negative economic data from the United States, including jobless claims at a 26-year high. The euro soared 2.3% to $1.3316 and the British pound rose 1.2% to $1.4974. The dollar fell 1.2% to 91.67 Japanese yen.
Market Pulse
Dollar accelerates losses vs. rivals
Quote References
-0.41 -0.43%
More News from MarketWatch
Top Stories


text:
Quality Control
A worker performs realtime defect analysis on a semiconductor wafer.
The Midway
At the plant's "50-yard line" hallway, materials are moved along tracks overhead wafer bath These front-opening unified pods (FOUPs) take wafers through a "wet process."
Conductor Close-up
Here a 300-mm wafer is shown in detail inside a FOUP.


text:
Publisher's Description+
What's new in this version:
- Windows 7 Improvements and features.
- SFTP (SSH File Transfer Protocol) Support.
- Remote file editing with automatic upload on save.
- Automated file transfer scheduling with e-mail notifications.
- File transfer rules based on size, and, or date.
- Integrated language translation editor.
- Simplified user interface.
- Improved performance and compatibility.


text:
Search BizReport
News by Topic
- Advertising
- Search Marketing
- Email Marketing
- Loyalty Marketing
- Mobile Marketing
- Social Marketing
- Viral Marketing
- Trends & Ideas
- Internet Marketing 101
Beyond Marketing
BizReport : Tags : Tag Results
Tag Results
Tag Results
25 result(s) displayed (76 - 100):
BizReport | Internet July 30, 2015
Experts weigh in on the death of Flash
With a growing number of key technology players disabling or calling for 'the end' of Flash, many are saying this is finally the beginning of the end for the technology. If it is, in fact, the end for Flash, what... >>
BizReport | Advertising July 30, 2015
How travel brands can stop fraud
The online travel space is expanding quickly. Consumers are looking for trip information across devices, but many want options in lodging, airfare and car rentals as well as content, and as with all ecommerce the experience is key. But among... >>
BizReport | Advertising July 29, 2015
Brands: How to use programmatic TV buys to your advantage
Programmatic TV is a new form of selling ad space driven by the desire for new buyers to TV. According to one expert programmatic TV will see big increases over the coming months. Here's how it could affect brands. ... >>
BizReport | Advertising July 29, 2015
Top 3 tips that will help you use location more accurately
Location data provides a plethora of insight into consumers on a very granular level. It provides context around where, when and how consumers are interacting with brands as they traverse between the physical and digital world.... >>
BizReport | Advertising July 28, 2015
Massive mobile ad fraud uncovered
A report by fraud detection firm Forensiq has found thousands of malicious apps in official app stores that are carrying out ad fraud. ... >>
BizReport | Advertising July 27, 2015
Brands: Why you need to improve on location
In real estate experts tell us, "location, location, location". One expert says a similar mantra - one of location data - could be used with online marketing. Brands need to up their location game, says one expert, if they want... >>
BizReport | Advertising July 24, 2015
Radio most effective channel driving sales for Amazon's Prime Day
Analysis of how advertising helped Amazon to success in its inaugural Prime Day sale event reveals that radio was the most effective channel at converting awareness. ... >>
BizReport | Social Marketing July 24, 2015
New Twitter tool enables advertisers to plan ahead for big events
Twitter has increased its appeal to marketers with the unveiling of a new way to connect with users surrounding big events and holidays. ... >>
BizReport | Advertising July 23, 2015
Ad Roundup: Releases focus on interaction, location
In today's advertising roundup: two new releases looking at customer interaction and location to boost brand's revenue. ... >>
BizReport | Advertising July 23, 2015
Programmatic ad buying rises in UK as ad viewability falls
According to European ad verification firm Meetrics, while programmatic ad buying has many benefits to advertisers, there is a big question mark about inventory quality. ... >>
BizReport | Ecommerce July 23, 2015
Get real: Ditch soulless stock photography for user-generated content
Perfect teeth on well-groomed models with flawless figures. Big smiles while eating salad. The stuff of stock photography. But do these images resonate with today's consumers? ... >>
BizReport | Advertising July 22, 2015
Ad Roundup: Acquisitions and partnerships to give marketers more info
In today's advertising roundup, a trio of announcements regarding partnerships and acquistions that should set up brands with more insight into their customer bases or their infrastructure. ... >>
BizReport | Advertising July 22, 2015
Experts: How SMBs can achieve early success
Small businesses have a lot of hurdles these days - there is website design, there are larger brands taking up more online space, there are shoppers who are 'ad blind'. Six experts are offering their top tips to help SMBs... >>
BizReport | Advertising July 21, 2015
Ad Roundup: Tools to focus on business knowledge
In today's advertising roundup: new tools in the online space could set businesses up to better understand their customers. ... >>
BizReport | Advertising July 21, 2015
Top 3 tips to build a strong marketing team
Marketing teams are becoming more important every day. No longer are these teams relegated to developing advertising campaigns, in many cases marketing teams are also social media experts, they plan both online and in-person events and sometimes liaise between departments.... >>
BizReport | Advertising July 16, 2015
Ad Roundup: Using relevance and personalization to engage
In today's advertising roundup: two new releases that focus on customer engagement, and how an ad agency's 'yes' pitch to non-profit donors landed a big award. ... >>
BizReport | Ecommerce July 15, 2015
Reports: BTS shopping will be strong
In just a couple of weeks moms and dads across the US will begin back to school shopping for their K-12 and college aged kids. New jeans and backpacks, computers and mobile devices as well as paper notebooks and pens... >>
BizReport | Advertising July 15, 2015
Ad Roundup: Platforms to personalize content
In today's advertising roundup: a trio of releases setting up publishers and marketers to serve more relevant, personalized ads to consumers. ... >>
BizReport | Advertising July 15, 2015
Top 4 tips to improve customer experience through data
The customer experience is becoming more important to retailers and marketers every day, and that experience must be equal across devices as well as in stores. One expert offers advice on how to use data to improve the customer experience.... >>
BizReport | Advertising July 14, 2015
Ad Roundup: Platforms to help control ad costs
In today's advertising roundup: a new option that would enable brands to better control video spending as well as a platform partnership and an ecommerce announcement that underlines the health of etailing. ... >>
BizReport | Advertising July 14, 2015
Which European cities attract the highest suggested bid amount on Facebook?
While London, Paris and Monaco may be the most expensive places to buy property, all but London falls outside the top ten most expensive places to buy Facebook advertising, according to new data released by Kenshoo.... >>
BizReport | Advertising July 13, 2015
Billions of ads fail on mobile. Why? Flash.
iOS devices have never had native support for Flash, and Android has not supported it for the last few versions, yet according to a study published by open ad management firm Sizmek, many advertisers continue to use Flash for mobile... >>
BizReport | Advertising July 10, 2015
Facebook announces CPC change that will please advertisers
Advertisers who care about clicks more than engagement via Likes and Shares will be more than happy with Facebook's recent changes to how they charge. ... >>
BizReport | Advertising July 09, 2015
Ad Roundup: Platforms to protect data, give answers
Today's advertising roundup includes details of a new funding round for a data protection agency as well as a CRM platform that gives customers quick answers. ... >>
BizReport | Advertising July 08, 2015
Ad Roundup: Platforms to increase relevance
In today's advertising round-up a trio of announcements setting online brands up for better engagement through translation, experience and relevance. ... >>
Latest Headlines
- SMBs: What to look for in your next device
- 3 ways analytics may be clouding your strategy
- Why brands need to know document search
- Half of cybersecurity experts say mobile payments are not secure
- Amazon the go-to place for consumers to search for products
- Which holiday season promos will motivate consumers to buy?
- Display ad revenues continue to rise despite ad blocking
- Mobile camera functionality key to capturing Millennials' loyalty
Featured White Papers
- The Retail Marketer's 2015 Holiday Playbook
Download this ebook to learn how to increase Average Order Value, drive last minute purchases, increase sales, extend in-store shopping...


text:
« Receptors, Moving and Shaking |
| The Infinitely Active Impurity »
Posted by Derek
Nature has a short item on the Pfizer paper that questions the reproducibility of some key sirtuin work (covered here and here). There are some good points to temper the pessimism. Leonard Guarente of MIT, a key pioneer in the field, says:
". . . that the latest findings are neither surprising nor worrisome. The compounds may work only with fluorophore-conjugated peptides in vitro, says Guarente, but the situation is different in cells and in animals. The Nature paper, among others, went beyond the test tube and indicated that SIRT1 was more active in cells and in animals after application of the Sirtris compounds. Furthermore, resveratrol administration made no difference to the lifespan of yeast that did not have Sir23, indicating that the compound's action depends on this gene.
According to a statement from GlaxoSmithKline, Ahn's conclusion "ignores any possibility of direct activation of SIRT1 that may occur in a cellular environment that is not reproduced in vitro".
True, but there's still that problem of the Pfizer group not being able to reproduce the in vivo effects, which to me was perhaps the most worrisome part of the paper. Now, it's worth remembering that animal studies are not the easiest things in the world to do right, since there are so many variables. Small differences in animal strains and the like can sometimes throw things off severely. Even the Pfizer group admits this readily, with Kay Ahn telling Nature that "every in vivo experiment is a little bit different" and that "Under our conditions we didn't see beneficial effects, but we don't want to make a big conclusion out of those results."
That's an honorable way to put things, I have to say. Rather less honorable, though, at least to me, is David Sinclair's response from the Sirtris team. See what you think:
A possible explanation for the discrepancy, says Sinclair, is that Ahn and her colleagues did not provide information on the characterization of the compounds, which they synthesized themselves. So there is no way of knowing how pure they were or whether they're the same as those made by Sirtris. "The fact that mice died indicates that there may be an issue with purity,".
A possible explanation for the discrepancy, says Sinclair, is that Ahn and her colleagues did not provide information on the characterization of the compounds, which they synthesized themselves. So there is no way of knowing how pure they were or whether they're the same as those made by Sirtris. "The fact that mice died indicates that there may be an issue with purity,"
That's. . .not so good. In fact, it comes close to being insulting. Although I say a lot of uncomplimentary things about Pfizer's management, the fact remains that they have a lot of very good scientists there. And I assume that they can reproduce Sirtris's published procedures to make the sirtuin ligands. If they can't, frankly, that's Sirtris's fault. Everyone (well, everyone competent) checks out compounds thoroughly before putting them into an animal study. Asking "Are you sure you made the right stuff?" at this point is really a bit much, and doesn't do anything improve my opinion of Sirtris. (Which opinion actually was pretty good - until recently).
Comments (40)
+ TrackBacks (0) | Category: Aging and Lifespan | Drug Assays
1. Anonymous on January 25, 2010 9:51 AM writes...
Hey Derek, it looks like you mixed up Sirna and Sirtris in your title.
2. theotherguy on January 25, 2010 9:59 AM writes...
Questioning the compound purity is pretty random. Then again, Sinclair is a total joke. Between shilling for the reveratrol hawkers and the 60 Minutes performance, he has no credibility. Maybe he's been following the reactome story and figured "When in doubt question the chemical characterization." Yet another example of my old maxim, Don't Let Biologists Talk About Chemistry.
3. Postdoc for life on January 25, 2010 10:09 AM writes...
Take a look at the procedures Sirtris published. http://pubs.acs.org/doi/abs/10.1021/jm8012954 Who in their right mind would design this route? And the characterization is incomplete in several instances. What is the final salt form? I have actually made SRT1720 recently for an academic research group and had to scrap the published route.
4. Hap on January 25, 2010 10:21 AM writes...
If Sinclair's stuff is wonky, then a better motto would be "Don't let scientists talk about chemistry to VCs or pharma executives", because this wouldn't be as much of an issue if GSK hadn't sunk $720M into it.
If you can't rely on your in vitro tests to determine in vivo activity, where do you even start to develop drugs?
5. Anonymous on January 25, 2010 10:41 AM writes...
This statement that is attributed to Lenny Guarante in the Nature news article is not true:
"The Nature paper, among others, went beyond the test tube and indicated that SIRT1 was more active in cells and in animals after application of the Sirtris compounds."
One of the amazing things about that Nature paper (Nature. 2007 Nov 29;450(7170):712-6) was that the authors never showed that their compounds activated SIRT1 in animals (e.g., by blotting for acetylation of a SIRT1 substrate). So there is no evidence that the compounds modulated the target in vivo. Even the evidence that the Sirtris compounds activated SIRT1 in tissue culture was incredibly weak (Figure 1c; look at those error bars!)
The bigger lie in this whole field has been that we all know that Sirtuins and resveratrol are important for aging, but we just don't know the mechanism. Not true! Lenny Guarante's original discovery that Sir2 is required for the effects of dietary restriction in yeast has really been marginalized by later experiments -- it is only true in a specific yeast strain, in a specific assay of yeast life-span, and involves a mechanism (reduction of rRNA circles) that no one believes is relevant to humans. Sinclair claimed in Science that resveratrol extends lifespan in worms and flies via Sir2 (Science. 2004 Jul 16;305(5682):390-2). Linda Partridge carefully showed that these effects are not reproducible (Mech Ageing Dev. 2007 Oct;128(10):546-52) and Andrew Dillin showed that Sir2 is not involved in dietary restriction in worms (PLoS One. 2009;4(2):e4535. Epub 2009 Feb 20). Four different labs have shown that Sinclair's claim in Nature that resveratrol activates Sir2 is false (J Biol Chem. 2005 Apr 29;280(17):17038-45., J Biol Chem. 2005 Apr 29;280(17):17187-95, Chem Biol Drug Des. 2009 Dec;74(6):619-24., Pfizer paper in J Biol Chem. 2010 Jan 8). Sinclair's own data shows that resveratrol does not extend the lifespan of normal mice (Cell Metab. 2008 Aug;8(2):157-68.). Several transgenic mice have been made that overexpress/activate SIRT1; none of them have extended lifespan.
So what are we left with? Lenny Guarante speculating that the Sirtris compounds activate SIRT1 only in cells and do so by a mysterious mechanism (without presenting any data to support this). David Sinclair, a biologist, speculating that Pfizer failed to properly synthesize the simple Sirtris compounds.
What a joke.
6. anonagain on January 25, 2010 11:30 AM writes...
Adding to Anonymous' list, there's another paper from Anne Brunet's lab that shows that resveratrol lifespan extension in worms is dependent on AMPK (Aging Cell. 2009 April; 8(2): 113–127).
7. anonymous on January 25, 2010 11:56 AM writes...
Good !
Now we need to setup AMPK assay and will sell some screening artifacts to GSK for $$$.
Hmm, I think we already have that plasmid in a freezer...
8. CMCguy on January 25, 2010 12:07 PM writes...
Derek you say 'Everyone (well, everyone competent) checks out compounds thoroughly before putting them into an animal study. Asking "Are you sure you made the right stuff?"'.
Not that long ago I would have disagreed that this was the predominate MO of many places as common medchem purity was a "clean" NMR and "one-spot" TLC and maybe an IR for characterization (OK for grad work right?). Since likewise at many shops the medchem group often prepped the initial material for animal testing that same criteria was followed. Although typically would be the correct structure claimed the purity was sometimes not as good as advertised, as process chemists later found to significant consternation. It has changed now that HPLC is wide-spread there is greater probability of decent purity however until the Analytical chemists really tackle the methods there is always suspicion that many impurities are hidden and one of those could be an extra potent species responsible for the activity observed.
As far as #2 theotherguy statement "Questioning the compound purity is pretty random." I do disagree as if Biological or Clinical results do not match expectations/previous results the default position is that the (Syn)chemists must have done something wrong/different. The factor that their testing environments are frequently much more variable seems to be forgotten when they can blame the "new lot of compound".
9. d on January 25, 2010 12:39 PM writes...
Agree with CMC!!
In my experience, every time there was an irreproducible result in a biological assay, the common response from the person responsible for it was to call back the chemist(s) responsible and question his/her/their ability to reproduce the original compound.
10. Mark on January 25, 2010 1:16 PM writes...
I have personally met Kay and have talked science as a competitor and I can honestly say, she knows her stuff and is pretty adept at saying the right things.
David Sinclair's response sounds typical. Whats the first thing anyone does when someone can't replicate your work? They suggest you don't know what you are doing and its something YOU did that is wrong with your data cause our is right. Pretty tacky (and arrogant) to suggest it in public like that and really makes me never want to work there.
11. Anonymous on January 25, 2010 3:52 PM writes...
Shoddy science = non-reproducible work. There are several causes. I am listing them in the order I have seen in my short life 1) not carefully looking at your own data 2) never reproducing your own work, but rushing to publish and last but not least, pure fabrication. Biologists are extremely guilty of not being quantitative. This is coming from a biologist.
I have seen examples of this in academia, small biotech and, of course, big pharma.
Thank god there is a lengthy approval process.
12. Hap on January 25, 2010 5:08 PM writes...
GSK's responses (CancerMan's quote in comment 36 on "Sirtuin Scenarios" and above) to Pfizer's and Amgen's research doesn't really speak well of them. To say that Pfizer was trying and failing to prove a negative, for example, seems like either a dumb misreading of science or an intransigent one - people try to duplicate your results, and if they can't do so they ask why. Even if people can reproduce your results, they may suggest alternative models of reality consistent with your data. Finding another such model isn't "proving a negative" (other than to your stockholders) but proposing (and supporting) an alternative, testable hypothesis.
Suggesting that your compounds can only be tested effectively in vivo is possibly true (sulfas), but is a theory that would require more evidence to support, and would put a deep crimp in generating effective analogs. If Anon #5's references tell the story, the in vivo activity of their compounds might not exist either.
It seems like it would have been better for GSK and Sinclair to have said nothing - if their compounds work, then these problems will have been by necessity defeated, and the eventual research will make that clear. Throwing out nonsensical and insulting statements makes it sound as if you have nothing better to throw out, a counterproductive implication.
13. theotherguy on January 25, 2010 5:11 PM writes...
I didn't mean to suggest that one can't ask into the details of compound purity in the heat of scientific experimentation, anymore than one shouldn't ask into assay reproducibility. That's totally appropriate and we should all be open and ready to defend the validity of our work product. But to question such an elementary aspect of one's work with no evidence (other than conflicting with your own claims) is, as Mark so rightly describes, tacky.
I think the rush-to-publish bug that Anonymous describes is worse in academia, where 99% of the work will never face the scrutiny of outside verification, and where there's no checks standing above the PI. At least in industry, there's more than reputation at stake ($$$ and jobs). Sinclair, like a true academic, got an exciting result and his first thought was "Tenure is mine!' In industry the first thought would be "What more experiments can I do to convince my boss?"
Say all you want about industry, the bullcrap quotient is alot lower. Money has that effect. Consider Sirtris the exception that makes the rule!? ;)
14. Skeptic on January 25, 2010 6:17 PM writes...
"Say all you want about industry, the bullcrap quotient is alot lower. Money has that effect."
Thats a strange comment given that a massive decades long credit boom (which drove asset prices up) fueled a monstrously bloated and highly speculative industry in the first place. What possibly could be more bullcrap than handing out debt money to anybody with an unproven idea? If nobody really understands biology very well then why does industry exist?
You guys need to pick up a book on fractional reserve banking rather than pointing to the "MBA's are evil" conspiracy.
15. Hap on January 25, 2010 7:05 PM writes...
But, even if there's lots of money because it's cheaper to borrow and invest than it should be, shouldn't someone actually be determining whether an idea is good and financially viable before they invest? When money is cheap, people can make riskier investments, but they still should have some idea what the risks are (and ideally some sort of quantitation, to give an estimate of whether the investment makes any sense). Also, if the surplus of credit means there's lots of money around, the cost of investing goes up (because your competitors have money, too), so there still ought to be significant emphasis on making the correct investments.
It doesn't seem as if all the good ideas have been funded, let alone all the bad ones, so someone has a methodology for choosing which ones to fund (at least in part, what one might blame MBAs for) - either the methodogy works, and was ignored in this case, it works, and was employed by incompetent people, or it doesn't work (or doesn't work as well as a supposed). I thought the recent crash seemed to depend on the third case (people assumed far higher risks than they realized, because the underlying models assessing that risk were flawed, or dishonest, and their leverage made that mistake consequential to others). Sirtris may be a risky investment that had just enough of a chance for a high payoff to work (because of cheap credit), but the claims by lots of people that the likelihood of payoff was lower than postulated (or zero) and that that data was ignored may put this investment in the second category.
The choice to invest externally (outsourcing, purchasing other companies) seems to be based not only on the cheapness of credit but on presumed models of risk and productivity that don't seem to be working (or, worse, whose functioning may not be determinable at all) and an ignorance of long-term goals - these seem to be the hallmarks of quantitative business, and of MBAs, hence the blame. Alternatively, this could just be old-fashioned robbery by scientific executives who don't care, or old-fashioned ignorance (people who don't know business, but think they do) by people who should know better (opportunities made more lucrative by the presence of cheap credit). It's getting hard to tell.
16. Anonymous on January 25, 2010 7:05 PM writes...
it seems odd that guarante's statement about what data was presented in the Sirtris Nature article was repeated by the Nature news reporter as if it was a fact, even though the data he cites is clearly not anywhere in that article. I mean, did the reporter even bother to read the Nature paper? it seems particularly bad to get something like that wrong when the paper in question was published in the journal that you write for!!! it gives one the impression that the people at Nature have no idea what is going on.
17. CMCguy on January 25, 2010 11:53 PM writes...
theotherguy I probably should have given more credence to your context then the actual phrase you used because this was a tacky/arrogance tone so not disagreement there. However more times than I can count I have had to defend the compound/purity/process when an oddity was observed in bioassay or even clinical result so it does not appear "pretty random" and it was the inherent presupposition of certain groups/individuals.
I am not sure I understand what you mean about industry's bullcrap quotient being alot lower. Perhaps if talking about focus on publications I can see a point but although it may come from different sources the industry generated manure can be just as deep. Industry could not as noticeable since Marketing can wrap it in a nice box with a ribbon (since they get so much practice on the stuff they produce).
18. anon the II on January 26, 2010 9:04 AM writes...
While we're on the topic, this just showed up on Forbes.
19. theotherguy on January 26, 2010 10:34 AM writes...
All I will say is this: Anyone who's ever been in the room when the VCs and their BS sniffers come to determine whether or not your research deserves that second round of cash, knows that they cannot be snowed. In my experience, an investor and his cash are not parted by rosy hand waving, but by hard data. There are exceptions of course, and Sirtris may be one, but if it were so easy to wheedle money out of the hapless, wouldn't we all be working for start-ups rolling in cash?
20. Anonymous on January 27, 2010 3:12 AM writes...
@ 19. But Sirtris had that kind of data - both in vitro and in vivo. VCs and their cash might not be easily parted, but they're unlikely to question in detail how the experiments were run, what controls were used, whether there could be assay artifacts explaining the results etc. The problem is that the Sirtris data doesn't appear to stand up to *scientific* scrutiny
21. Will on January 27, 2010 11:49 AM writes...
I love this kind of explanation by the Sirtus scientists.
It is the "inverse-Occam's razor" principal.
The least parsimonius explanation must be the correct one.
I have seen this so many times following up on Nature, Science, Cell, Patent, and Inlisensing deals.
>> Maybe we are missing something important from our in vitro assay. Maybe it doesn't work in TRIS- only in HEPES? Are we sure we have made the correct isomer? Well maybe it is cell type specific.. Maybe our batch of HEK cells are different to theirs... Well maybe it doesn't work with DMSO as the solvent... Well maybe it only works in this rat strain...
22. Hearditallbefore on January 27, 2010 12:07 PM writes...
The head of chemistry at Sirtris is from a place in Cambridge that's known to be full of incompetent stuffed shirts., nothing more needs to be said
23. chemist on January 27, 2010 12:21 PM writes...
Quote from above,
"It seems like it would have been better for GSK and Sinclair to have said nothing"
EXACTLY, and if they were so certain of their results that's EXACTLY what they would have done, "said nothing". Hell, it would even be in their interests to guide other researchers as to how to reproduce their results.
Come on, we all know what this is really about, the same tired old smoke and mirror show put on for the unsuspecting investor.
The real danger with these shenanigans is that the people with the money, who potentially fund our research and cut our paychecks, are going to become more and more jaded regarding the whole drug discovery enterprise. This is the last thing we need right now given the current environment.
24. Anonymous on January 27, 2010 1:58 PM writes...
So I'd like to throw out a couple questions.
It would appear that the GSK management team has made numerous poor but expensive investments(e.g. Sirtris, Praecis, Genelabs, Anacor, ect.) Further, it also appears as if this management team (who have minimal or no small molecule drug discovery experience) have ignored the council of their internal experts based on comments posted on this blog regarding the purchase of Sirtris as well as Witty admitting in the Forbes article that GSK researchers felt their investment in Anacor was "completely mad".
At what juncture is there sufficient grounds for their shareholders to sue and have this team removed? And do former research staff working in the identical therapeutic areas to those companies listed above who were layed off to offset the cost of these investements deserve compensation? Is there precedent for either?
25. cancer_man on January 27, 2010 10:20 PM writes...
I still don't understand why most posting are so _positive_ that the Sirtris research will ultimately prove to be a bust.
I'm still waiting for studies that are expected to be published in coming weeks.
26. sgcox on January 28, 2010 4:47 AM writes...
#25 Because, as I understand, several posters have very good first hand experience with this garbage.
27. Hap on January 28, 2010 10:26 AM writes...
#25 - Besides the comments from people who might be in a position to know about Sirtris (and whose comments you can take with salt as needed), the likely difficulties with testing (they'd have to test in whole cells or in vivo, and there may be potential metabolic liabilities with things that look like resveratrol), there's also the idea that GSK and Sinclair aren't behaving as if they ought to if they think they have a fundamentally sound idea. If the studies published were expected to be positive, for example, why not just say that they think that future results will validate this expenditure and the line of research? (The production of a drug would also validate their research, but that might not happen for lots of reasons not necessarily related to the research even if it's sound.)
You don't need to defend quality research with bad logic (the "trying to prove a negative" bit) and smokescreens - it shouldn't need any defense at all. The comments would indicate that either GSK and Sinclair don't know how to defend their research (fairly stupid, since you would figure that multibillion dollar companies could afford some good PR people) or they have little of quality to defend. I don't think additional research papers would improve their image, because of the refs in comment #5 (lots of the positive research has been refuted or diminished in scope), but probably only positive clinical results would help (although even that wouldn't justify the expense of buying Sirtris, unless the mechanism of action fits with their sirtuin research).
28. Anon on January 28, 2010 7:11 PM writes...
I just want to put out there that I have seen the wrong thing go into an animal study before, and can take a lot of analytical doglegging to figure out what happened.
However, its a lot less common / more disturbing to have it happen in multiple situations or studies, and its certainly not an accusation I'd make publicly within a company nevermind to another!
29. cancer_man on January 28, 2010 10:40 PM writes...
There are aspects to this that don't make sense to me. Expanding on what I wrote in a previous post:
1. A guy who says he worked in Harvard's lab commented on Dereck's post " I can assure you threre is a lot more to this story than you are letting on." Now that is an accusation, maybe unintentional, that Derek is actually holding back something. I don't assume this, but that is a strong statement.
He continues, "For one, SIRT-1 is just one of many sirtuin proteins that GSK has access to as a result of the Sirtris deal. SIRT-6 knockout mice have a profound premature aging phenotype, and SIRT-6 has also been shown to modify several of the pathways involved in insulin signaling. While I agree that the Pfizer data is troubling, I think we are a long way from justifiably writing off the sirtuin family of proteins."
2. I don't think Sinclair's statement is so great, although I thought he said last fall that they may be wrong about the mechanism, implying that something still works.
3. Based on a couple of interviews I've seen, Guarente doesn't come across at all like a hypster. If someone like him says "the latest findings are neither surprising nor worrisome" it seems that there may very well be a new turn to the story within a few weeks although maybe not, and he may be wrong.
4. I can't judge, but one comment on the previous post heaped a lot of criticism on the Pfizer study.
5. There were already three studies that showed resveratrol didn't affect SRT 1 "directly." Why does the Pfizer study, assuming correct, add anything sifnificant?
6. Why did Pfizer release the study right after the SRT 501 cancer trial finished and right before Sirtris will supposedly have publications that according to Sinclair are "promising"?
I just don't see what motivated Pfizer to conduct that study. Either GSK has something, or they don't.
30. Anonymous on January 29, 2010 6:06 AM writes...
were PFE bidding for Sirtris? If so, maybe they are just getting round to publishing some of their own due diligence work
31. anonymous_too on January 29, 2010 9:49 AM writes...
#24 Anonymous-
I'm not sure you should lump the Praecis acquisition in with the rest. First, it wasn't expensive, ca. $30M once you account for Praecis cash on hand. Second, they are still operating the old Praecis site with something like 50 people, 3 years after the purchase. The fact that they've survived the layoffs in the interim would indicate to me there's something of value there.
32. Anonymous on January 29, 2010 11:06 AM writes...
cancer_man #29
the difference between the pfizer study and the previous three studies is that pfizer paper showed that the three new "1000-fold more potent" sirtris compounds are also assay artifacts; we already knew that resveratrol was nonsense, but this paper showed that the new compounds are false positives for *exactly the same reason*.
more remarkable, the pfizer paper showed that the new sirtris compounds are incredibly promiscuous, inhibiting dozens of ion channels, GPCRs, enzyzmes in a counter-screen at 10 uM. So basically, the compounds do not activate SIRT1, but they do inhibit dozens of random targets. the in vivo data is meaningless.
33. cancer_man on January 29, 2010 9:00 PM writes...
But resveratrol also failed to activate SIRT1 yet many studies have shown good results in mice and a few studies have shown positive results in humans.
If the studies showed resveratrol activated SIRT1 but the compounds didn't then I'd say the new compounds are in trouble and GSK wasted a lot of money. But I think interesting possibilities remain and will wait a few more months before calling it over.
Apparently Derek also thinks there is a chance the compounds may prove effective. He is in the field and I'm observing from a different field in science.
34. Anonymous on January 29, 2010 10:24 PM writes...
Derek is just trying to be polite.
35. cancer_man on January 30, 2010 12:40 AM writes...
I guessed Derek might just trying to be polite. The one poster who worked in the Harvard lab said he was not adding important informationn. No idea.
I still don't get Pfizers incentive since we'll no soon enough what Sirtis' results are. To me, it seems like a publicity game, but again the incentives aren't clear.
36. Anonymous on January 30, 2010 9:19 AM writes...
re: the pfizer scientists' incentive, how about "desire to correct an enormous lie that's been propagated throughout the scientific and public press."
that sounds like plenty of incentive to me. i mean, if we don't care about such things, why bother doing science?
37. Anotheranonymous on January 30, 2010 10:08 AM writes...
#31 Anonymous_too
Former Praecis survived the layoffs because not to do so would require senior management who bought them, again against the advice of their own research staff, to acknowledged their mistake. Internally Praecis is widely thought to have been a bit of a flop, to the great surprise of nobody who was around at the time of Affymax. As with the other acquisitions, internal scientists ended up having to teach them how to do drug discovery when the hype was shown to be just that...
38. cancer_man on January 30, 2010 8:24 PM writes...
With so many poor publications, why are we to assume that Pfizer has a solid study? I'm in no position to judge, but one commenter laughed at it.
I'll assume it is a sound study, but it is hard to see how we know at this point that Sirtris "perpetuated an enormous lie." Maybe so, but that won't be known for a while longer. And why weren't the previous three studies that showed resveratrol didn't activate SIRT1 sufficient evidence. Suddenly it is Pfizer, GSK's main competitor, that is the decider?
Speaking prior to the Pfizer release, Guarente gave an interview where he said how little is still known about sirtuins and that his lab was at the "very tip of the iceburg."
39. Skeptical scientist on February 10, 2010 8:42 PM writes...
Wow. Hey guys. Do the world a favor and go edit the wikipedia page of Sinclair, Sitiris and resveratrol. I am glad to see that there are still critical thinkers left in the joke that academic research has become..
40. CG on August 19, 2010 3:06 PM writes...
Derek, just wondering if you intend to follow up on this saga some months later, what with Sirtris' recent publication by Han Dai et al. in J. Biol. Chem.? The evidence gathered by the Sirtris team provides a satisfying explanation of the peptide substrate-structural dependence of SIRT1 activation and in fact the evidence is at odds with that of Pacholec et al. from Pfizer. As a (former) card-carrying enzymologist, I find the Sirtris data pretty convincing, but then I'm not surprised at its robustness, given that the leader of the effort is Ross Stein, who is a first-rate enzymologist.
Email Address:
Remember Me?
About Us |
Advertise |
Contact Us |
Privacy Policy |
Terms of Use
© Copyright 2006 Corante. All rights reserved. ()


text:
I'm like a college kid on summer vacation this year. Needless to say, this has allowed me to hone my cocktail mixing skills. Sad, but true. However, my "adversity" equals your quenched thirst. Below are a few of my favorite summer cocktails sure to be a hit at your next summer soire.
Ginger Pineapple Heaven (seriously is like heaven in a glass)
Pineapple juice
Pineapple slice
Mix 1 part Canton Liquer, 2 parts pineapple juice in a martini shaker with ice. Shake and pour. Garnish with a pineapple chunk. Experience heaven.
St. Germain Cocktail
White wine (I suggest something dry)
Club Soda
Fill glass with ice. Add one part St. Germain, 2 parts white wine, and a splash of club soda. Note: Can also be made using prosecco.
The John Daly (Get it??)
Fill a glass with ice. Pour in 1/2 Firefly Vodka, 1/2 lemonade. Stir and enjoy. For an extra kick, you can add a splash of club soda.
Kiki's Special Sangria
**This is a (very) loose take on the sangria from Trata in Water Mill. You can get the recipe for their sangria, but they have some very unique ingredients that are basically impossible to find.
4 bottles Sauvignon Blanc
1 bottle White Zinfandel
10 oz. Triple Sec
6 oz. 7 Star Brandy
1 cup sugar
6 oz. Pomegranate juice
6 oz. 7Up
Fresh fruit cut into cubes or small slices. You can use whatever you like, but realize it will effect the way your sangria tastes. Apples, pears, grapes, pineapple, mango all work well.
Combine all wine, liquor and sugar in a large glass container. Stir until sugar is dissolved. Add fruit, pomegranate juice, and 7up and stir again. Refrigerate over night for flavors to combine. (If you can't wait that long- it's still fine to drink right away).
3 Comments on Why Did You Eat That: Summer Sipping
One of my new finds this summer is the Gin Mule. You should give it a try.
2 oz Gin (Plymouth preferably)
3/4 oz fresh lime juice
1/4 oz simple syrup
5 mint leaves
Mix everything in a shaker and strain into a tall glass filled with ice. Then top it off with Ginger beer (Regatta is the best. Reed's is a close second)
Sub vodka for gin and you've made yourself a Moscow Mule. If you want more ideas check out http://www.liqurious.com
I seldom leave a response, however i did some searching and wound up here
Summer Sipping | Why Did You Wear That?. And I do have 2
questions for you if you don't mind. Is it just me or does it look like a few of these responses look like coming from brain dead individuals? And, if you are writing on other online sites, I'd like to follow everything new you have to
post. Would you make a list of all of all your social
pages like your linkedin profile, Facebook page or twitter
1Pingbacks & Trackbacks on Why Did You Eat That: Summer Sipping
[…] nice rooftop 3. Buy cooler, beer, and mixes for margaritas and strawberry daiquiris (or try some of WhyDid's favorite summer beverages) and voila! You've found yourself miles away from Manhattan all the while still being right in […]


text:
Most excellent advice. Thanks, Bob! The whole 'relative to paper white' thing applies to papers with a cream base too, as you have the easel overlap to review and compare to.
The thing I find the most challenging is how much density in the highlights I need so that they are still present after I tone them. With pot ferri and sulfide toner, the highlight tone gets reduced some, and if I give a second bath in selenium, that tends to obliterate some of the highlight tone as well, effectively increasing contrast. To get all of that just right is challenging to the Nth degree. At least for me. But I think it's about developing a sense for what the end result is going to be, and for me it has helped to use just two types of paper (mainly) for printing - Ilford MG and MGWT. This way it's easier to learn exactly how much the print will dry down, and how much it will bleach out during toning.
- Thomas


text:
- Product Highlights
- Formulated to Support Healthy Liver Detoxification & Function
- Supplies 600 mg of Fresh, Freeze-Dried Milk Thistle Per Serving
- Contains Naturally Occurring Lipids, Proteins, Fiber & Co-Factors
- More Complete Than Any Extract & Standardized for 3-5% Silymarin
SKU 023363301492 Quantity 120 Vegetarian Capsules Serving Size 3 Capsules Servings Per Container 40 Potency 600 mg Dietary Needs Kosher, Organic, Vegetarian Directions Health Maintenance: 3 capsules of Milk Thistle twice daily. Health Management: 4 capsules 3 times daily. Warnings Discontinue use if unusual symptoms occur. Consult your health care professional regarding the use of this product during pregnancy, with infants or with prescription drugs. Keep out of the reach of children. Ingredients Organic Milk Thistle (Silybum marianum) seed meal…for product label information including a complete list of ingredients, click all product images above.
- Product Details
Eclectic Institute Milk Thistle:
Contains Lipids, Proteins, Fiber & Co-Factors
More Complete than Any Extract
Flash Frozen & Freeze-Dried
Cold Pressed Whole Seeds
Not an extract
No Solvent Residues
Independent Lab Analysis
In-House Lab Assay
Fresh Freeze-Dried
Silybum marianum
Seed Meal
A Dietary Supplement
Fresh Upgrade
3-5% Silymarin
Consistency Without Chemicals
100% Kosher
Milk Thistle Brand: Eclectic Institute5 stars, based on 1 review(s).Rating:Price: $10.29 - In stock
- Why SuperSupplements?
Unbeatable Selection ~ We carry an unbeatable selection of the very best nutritional supplements, sports nutrition and natural personal care products. We continually refresh our selection so you always have access to the newest, most effective products right here in one convenient spot.
Satisfaction Guarantee ~ Your complete satisfaction with any Super Supplements purchase is guaranteed. You may return any item that does not meet your expectations within 30 days of purchase for a full refund of the product price. Guaranteed!
Free Shipping ~ Why pay for shipping when you can use those dollars for more great products? Spend $25 and enjoy free, fast shipping to most locations.
Passionate People ~ We love what we do. We work hard to bring you the very best products at the very best overall value every single day. If there is anything we can do to make your experience with Super Supplements a better one, we want to hear from you - with a passion!
Eclectic Institute Milk Thistle, 600 mg, 120 Vegetarian Capsules Reviews Showing 1 out of 1 reviews for Eclectic Institute Milk Thistle, 600 mg, 120 Vegetarian Capsules
Milk Thistle review posted by DF on 4/15/14
Eclectic Institute
Milk Thistle
1 fl oz Liquid
Eclectic Institute
Milk Thistle, Dandelion Tangerine
1 fl oz Liquid
Now Foods
Silymarin 150 mg
120 Vcaps
Gaia Herbs
Milk Thistle Seed, Low Alcohol
1 fl oz Liquid
Jarrow Formulas
Milk Thistle 150 mg
100 Capsules
Gaia Herbs
Milk Thistle Seed
1 fl oz Liquid
Earth Mama Angel Baby
Organic Milkmaid Tea for Breastfeeding M...
16 Tea Bags
Now Foods
Full Spectrum Minerals
250 Tablets
At Last Naturals
Vaginal Gel w/Vitamin E
1 oz Gel
Imperial Elixir
Chinese Red Panax Ginseng Extractum
10 Vials
Nature's Secret
2-Part Program
Super Supplements | 750 S Michigan St, Seattle, WA 98108 | (877) 454-3988


text:
See how Everleap compares to other hosts in real-world load testing:
See more test results and read about our methodology.
As modern application resource demands steadily increase, so do performance problems on traditional shared hosting web servers. Your applications are evolving, your hosting should evolve along with them.
Kyle needed a fully managed cloud hosting solution so Little Rock Techfest could focus on their application, and not worry about their website infrastructure.Read the LRTF story.
Jason's large, busy database was built to aggregate and analyze all of the world's tennis data, and as it grows, it thrives on an Everleap Managed SQL Server.Read the GoldenSlam story
Neil couldn't justify the high cost of Microsoft Azure for his hobby site, so he moved to Everleap and got the same performance for a lower price.Read the ezRider story
Jim at XWord Info needed multiple load balanced web servers for his complex site that crunches huge amounts of data, but he didn't want to break the bank.Read the XWord Info story.
Our fully managed SSD Reserved Cloud Servers and Managed SQL Servers are high performance without the maintenance headaches or hardware costs. If you are migrating from Windows Server 2003, now is a good time to make a move to cloud hosting. Everleap is built on Microsoft Windows Azure Pack, running on servers in our Los Angeles data center. It's a modern platform that's flexible, fast and will grow with you. Check out our plans.
Everleap is premium modern cloud hosting at reasonable, predictable prices. Compare our plans and even try one for free for 30 days. No limitations, no strings attached.
We're glad you're here.Technology has finally caught up to your imagination. It's time to plant your flag.
Try it free
ASP.NET hosting is our specialty, but the Everleap platform is extremely versatile, supporting all of latest Microsoft web stack technologies, including PHP and node.js. It's a scalable and robust hosting platform for third-party applications too, from an open source E-commerce application to a commercial CMS. You can see live demos of nopCommerce, DotNetNuke, WordPress, Kentico, Sitefinity, BV Commerce, BlogEngine and many other applications running on Everleap servers at on-everleap.com.
Copyright 2015 Everleap.comAll rights reserved. All trademarks are property of their legal owners.


text: Quick View save 36% Fridge Fonts by Suck UK $9.50 $6.00 Out of stock online These classic typewriter font fridge-magnets will definitely make your kitchen look effortlessly cool. Aside from being a modern and minimalist form of decoration, they are also a great way to write shopping lists, little reminders, poetry and messages to your family. 201 characters. See Details was


text:
The Signature glove is an ultra lightweight super thin glove, yet it still performs out on the trail. It feels like a 'second skin' on your hand, offering maximum bar feel and max airflow. We're proud to make this our Signature glove.
S, M, L, XL, XXL (Graphite/Black)View Fit and Sizing Info


text:
If you cross the Øresund Bridge a couple of times or more in one year, BroPas is the right solution for you. With a ØresundBizz® transponder behind your windscreen, you'll be able to pass through the toll station quickly and easily.
ChargesThe cost of a BroPas comprises an annual subscription fee and a price per trip across the bridge depending on the vehicle.
What you getA ØresundBizz® transponder that enables you to pass through the toll station's green bizz lanes. When an ØresundBizz® is affixed to the windscreen the toll fee is registered automatically.
The EasyGo service which allows you to drive through the automatic lanes and use your ØresundBizz® for payment at a number of locations in Denmark, Sweden and Norway. More on www.EasyGo.com
Practical informationPayment. When you order BroPas, you link the contract to a credit or debit card. The annual subscription and trips across the bridge with your ØresundBizz® will be debited directly from the card. More on payment
Delivery. It may take up to a week from the time you place your order until you receive your Welcome Pack containing your ØresundBizz® transponder and useful information. The Welcome Pack will be sent by post.
Use your BroPas immediately. If you wish to cross the Øresund Bridge before you receive the Welcome Pack, all you have to do is mail us your receipts for cash payment and we will refund the difference between the cash price and the BroPas price. Send your receipts within 30 days of purchase.
Read the terms and conditions here (pdf)
1) The short break price "SmutTur" applies for outward journeys made between 5 pm and midnight, Monday to Friday, and all day on weekends and holidays. Whenever you travel, you must use a ØresundBizz® transponder and make the return journey within six hours of departure.
With the Øresund Bridge you can use a variety of currencies and payment cards.
More about payment


text:
P-20 stands for Pre-K through graduate school and/or the workforce. A P-20 philosophy permeates the University System of Maryland. Under the leadership of the System's Chancellor, William E. Kirwan, and through the combined efforts of dedicated faculty, administrators and staff, the University System of Maryland has become a recognized leader in state and national efforts to ensure that all citizens can participate and benefit from the highest quality education. The USM P-20 office is housed in the office of Academic Affairs and has both an internal and an external focus.
The USM P-20 office works directly with the Departments of Education in the USM institutions on partnerships with the local school systems. These partnerships work to strengthen educational achievement from elementary school through college and beyond. The partnerships also create programs to encourage students to consider and prepare for college and works at the both Pre-K-12 and college levels to improve teacher quality.
The USM P-20 Partnership Initiatives have been funded through a variety of federal and private funds including grants from the Pew Charitable Trusts, the U.S. Department of Education Office of Teacher Quality, the National Science Foundation, and the American Association of Colleges Universities. In addition to the grant-funded activities, the USM P-20 office collaborates with state-wide partners to develop new programs, such as the Associate of Arts in Teaching degree (AAT), shared standards for written communication in first year writing courses, and "bridge goals" for mathematics alignment between high school and college.
Current Projects
Archived Projects
USM STEM & Competitiveness Initiative
Conference Presentations
E=MC2 Closeout Celebration Pictures
Governor's P-20 Leadership Council
The USM P-20 office works directly with Governor and his staff on the Governor's P-20 Leadership Council. On October 1, 2007, Governor Martin O'Malley established a P-20 Leadership Council of Maryland (the Council). The Council is a partnership between the State, educators, and the business community to better prepare Maryland students for the jobs of the 21st Century while enhancing the State's economic competitiveness by creating a workforce with 21st-century skills. The Council consists of not more than 35 members, including the Governor or his designee and representatives of the education (both K-12 and higher education), workforce creation, and business communities.
The Leadership Council is recognized nationally for its voluntary, inclusive organizational structure. It was one of the first states to establish a PreK-16 Partnership (now Governor's P-20), and it remains one of the more active partnerships in the entire nation. The state-wide goals of the Council include: enhancing student access to post-secondary education, especially for disadvantaged and minority students, by aligning high school expectations with college admission requirements; improving the quantity and quality of teacher candidates (and current teachers) so that every classroom has a highly qualified teacher; and strengthening communication and collaborative decision-making among the five organizations. For more information click here.


text:
The mission of the CCMTR is to promote scientific discovery and facilitate its clinical application to achieve the goal of improving the health of animals and humans. The needs of the patients direct the emphasis of basic research, patient samples provide the critical resource to investigate the basis of disease, and patient participation in clinical studies is required to generate the evidence needed to apply new drugs, vaccines and technology to the broader patient population. Initiatives at the Center are designed to develop the multidisciplinary teams necessary to bring an idea from the lab to the patient. The Center is home to service cores that provide advanced technology, collect and store clinical patient samples, and perform clinical trials to validate new medical interventions. North Carolina State University''s College of Veterinary Medicine (CVM) is a dynamic community whose members are dedicated to preparing veterinarians and veterinarian scientists while advancing animal and human health from the cellular level through entire ecosystems.
URL: http://www.cvm.ncsu.edu/ccmtr/
Resource ID: nif-0000-24380 Resource Type: Resource Version: Latest Version
drug, ecosystem, clinical, discovery, disease, health, human, patient, research, scientific, technology, vaccine, veterinary
Department Portal


text:
It stands to reason that the Nevada desert is an ideal place for a solar-power installation. Open space and sun abound.
May 2011: Safety
Featured Articles
Sort by
Web Exclusive
Systems |
| May 2011
Editor's Note: This is the correct quiz that was supposed to be included in the May print issue. We apologize for the mixup.
Safety |
| May 2011
Accidents involving electricity are common. All electricians should review the basic electrical hazard accident--prevention measures.
| May 2011
The nuclear reactor crisis in Japan has triggered a strong response among Americans, according to a major survey conducted one month after the crisis began on March 11 at the
Lighting |
| May 2011
Electricians and emergency personnel frequently require self-contained lighting of various types when responding to emergencies in situations where power has been interrupted


text:
Apogee - Aspen CG8050 Front Illuminated Interline KAI-8050 Monochrome CCD Camera with 35mm Shutter - Grade S
The Apogee Aspen CCD Camera series has a wide range of new incorporated features bringing professional astrophotography to a whole new level!... Learn MoreFREE SHIPPINGModel#: CG8050-S-G01-S35(48 States)
Apogee - KAF 16803 Imaging Systems - Alta U16M D07 CCD Camera and AFW50-7S Filter Wheel Package
The Apogee Alta U16M CCD Camera employs a Kodak KAF-16803 full frame sensor with microlensing and anti-blooming gates.Features the D07 body and is great for applications requiring large fields of view, like sky surveys and radiology... Learn MoreFREE SHIPPINGModel#: U16MD7-7S(48 States)
Apogee - Liquid Recirculation / Chiller UnitThe LR001 Liquid Recirculation / Chiller Unit provides precise control of the temperature of recirculated liquid for optimal cooling despite ambient temperature fluctuations ... Learn More
FREE SHIPPINGModel#: 400001(48 States)
Apogee - Imaging Systems - Alta U16M - DO7 Front-Illuminated CCD Camera with KAF-16803 Full Frame SensorThe Alta Design Team at Apogee worked hard over a two year period to bring this advanced degree of integration and performance to the astronomy market ... Learn More
FREE SHIPPINGModel#: U16M(48 States)
Apogee - Aspen CG8050 Interline Monochrome CCD Cameraincreases cooling performance in a smaller package, improves stray light baffling, adds a Network interface with a built-in web server, supports dual output CCDs up to 16Mhz and sets a ... Learn More
FREE SHIPPINGModel#: CG8050M(48 States)
Apogee - Ascent A29050 Color CCD Camera - Grade 2
The Ascent CCD Cameras are Apogee's most recent cameras to date for astrophotography.... Learn MoreFREE SHIPPINGModel#: A29050C-G2(48 States)
Apogee - Aspen CG16050 Interline Color CCD CameraThe Aspen CG16050 has a 16-megapixel interline transfer sensor with high quantum efficiency. The camera is available with a ... Learn More
FREE SHIPPINGModel#: CG16050C(48 States)
Andor/Apogee - 16.8 Megapixel CCD230-84 Back Illuminated Sensor Midband Flexi Cooled CCD Camera without Shutter
Andor's NEW iKon-XL is a TE-cooled, very large area CCD camera platform, accommodating big field of view sensors that are ideally suited to long exposure astronomy applications.... Learn MoreModel#: XL-EA01-C-O
Call for pricing.
Out of stock
Apogee - KestrelSpec Lite softwareKestrelSpec for Windows is designed for data acquisition and analysis using a CCD camera, a spectrograph and a computer running Microsoft Windows® ... Learn More
FREE SHIPPINGModel#: 400051(48 States)
Apogee - Aspen CG1 Full Frame Monochrome CCD Camera - Grade 1... Learn More
FREE SHIPPINGModel#: CG1M-G1(48 States)
Apogee - Aspen CG1007 Spectroscopy Monochrome CCD Camera... Learn More
FREE SHIPPINGModel#: CG1007M(48 States)
Apogee - Flange with 2 " thread (D05,D06)These flange adapters allow you to attach anything from an SLR camera lens to a large instrument pack to your Apogee camera. These units are machined precisely for accurate concentricity ... Learn More
Model#: 100454
Apogee - Aspen CG47 Full Frame Monochrome CCD Camera - Grade 0
The CG47 sensor is designed with anti-blooming, which makes it perfect for demanding scientific applications. It is based upon a full frame format, has a single ouput, and charge detection circuits on each side of the register to direct charge or split it.... Learn MoreFREE SHIPPINGModel#: CG47M-G0(48 States)
Apogee - Aspen CG42 Full Frame Monochrome CCD Camera - Grade 0The Aspen CG42 has a back-illuminated full frame 4-megapixel CCD with exceptionally high quantum efficiency. The standard midband coating has the highest peak in the ... Learn More
FREE SHIPPINGModel#: CG42M-G0(48 States)
Apogee - Aspen CG42 Full Frame Monochrome CCD Camera - Grade 1The Aspen CG42(MB) has a back-illuminated full frame 4-megapixel CCD with exceptionally high ... Learn More
FREE SHIPPINGModel#: CG42M-G1(48 States)
Apogee - Linux driver CD w/ supportApogee Software Development Kit (SDK) provides DLL's, source code, API calls, and documentation to Apogee Instruments' customers and approved 3rd party developers ... Learn More
Model#: 400053
Apogee - Aspen CG1050 Interline Monochrome CCD CameraAspen increases cooling performance in a smaller package, improves stray light baffling, adds a Network interface with a built-in ... Learn More
FREE SHIPPINGModel#: CG1050M(48 States)
Apogee - Alta F9000 Front Illuminated KAF-09000 Monochrome CCD Camera - Grade S
With faster readout speeds, the F9000 is a major step up in the Alta series line from Apogee!... Learn MoreFREE SHIPPINGModel#: F9000-S-D07-S63(48 States)
Apogee - Ascent A340 Color CCD Camera
The Ascent CCD Cameras are Apogee's most recent cameras to date for astrophotography.... Learn MoreFREE SHIPPINGModel#: A340C(48 States)
Apogee - Aspen CG2050 Interline Color CCD CameraThe Aspen CG2050 has a 2-megapixel interline transfer sensor with low noise and high quantum efficiency. The ... Learn More
FREE SHIPPINGModel#: CG2050C(48 States)
Apogee Imaging Systems have contributed to discoveries in many different fields, from astronomy to life science. They are operated in a variety of extreme conditions, from the Arctic to orbiting around the Earth. Apogee is proud of their accomplishments, but recognize that they must strive to continually improve products and processes.
From bio array readers and radiance measurement systems to backyard astronomy and bright field microscopy imaging Apogee supplied the tools for serious research and discovery work for over a decade. Apogee Imaging Systems are a corporate sponsor of the American Astronomical Society and support various local educational institutions.


text:
UN Votes To Grant Non-Member Observer State Status For Palestine
Palestinian Authority President Mahmoud Abbas concludes his address... NyhetsfotoDiplomati,Förenta Nationerna,Förenta nationernas generalförsamling,Horisontell,Israel,Mahmoud Abbas,Palestinian National Authority,Palestinsk kultur,Politik,Staden New York,Tal,Titta,USA,Votering,ÖverkroppsbildPhotographer Spencer PlattCollection: Getty Images News 2012 Getty ImagesNEW YORK, NY - NOVEMBER 29: Palestinian Authority President Mahmoud Abbas concludes his address to the General Assembly at the United Nations before a UN General Assembly vote on upgrading the status of the Palestinians to non-member observer state on November 29, 2012 in New York City. With many European nations in favor, it looks certain that the Palestinians will win the coveted U.N. recognition as a state today. (Photo by Spencer Platt/Getty Images)


text:
Icons of American Photography. This is a traveling exhibit from the Cleveland Museum of Art. It was on display there, Jun 24 - Sep 16, 2007. There are some really great works as outlined in your link. This is a wonderful exhibit of historic prints. Put it on your must do list.
Welcome to APUG Alan.
John Powers


text:
Your letters: East county
Filtering out the filters
The concept of "electable" candidates is a ploy of the conglomerated corporate media pundits used to dissuade voters from looking at the substance of where candidates stand on issues truly important to the vast majority of Americans the middle and working classes.
"Coverage" is limited to those candidates who are acceptable to the military-industrial complex the same candidates whose campaign coffers swell with the corporate dollars needed to buy expensive but meaningless 30-second spot ads on TV. The pundits will talk about money. They will talk about polls. When they do that, they don't have to talk about what is important.
It is time for Americans to stop being passive consumers who limit their choice to the packaged commodities aka "leading candidates." Instead, each of us needs to assume the responsibility of active citizenship.
Go to the Web sites of each candidate. Compare what they say or don't say about issues that truly matter. (Try http://Kucinich.us). Only when each of us votes on the basis of substance will we achieve the democracy envisioned by this nation's founders.
Ernest A. Canning,Thousand Oaks
Give Metrolink a try
Re: your May 17 article, "Public agencies also feeling sting of soaring fuel prices":
The article mentions the effect rising fuel prices have had on municipal budgets throughout Ventura County.
As a member of the Moorpark City Council and vice chairman of the board of directors of the Southern California Regional Rail Authority, the operator of Metrolink commuter train service, I have witnessed these effects from two different angles.
Metrolink operates more than 140 trains every weekday that consume several million gallons of a special blend of clean-burning, low-sulfur diesel fuel every year. Between 2005 and 2006, the cost of this fuel increased more than 18 percent and led to an increase of fuel costs of nearly $2 million.
Many do not realize that while gasoline prices have increased an average of 20 percent per year since 2002, diesel fuel prices have increased an average of more than 30 percent over the same period. Yet, by carrying so many passengers per mile, even with this fuel price increase, Metrolink has been able to keep increases in fares to an average of less than 4 percent per year since 2002. As an added benefit, the amount of carbon dioxide spewed into Southern California is significantly reduced because commuters are riding trains powered by low-sulfur fuel instead of driving their automobiles.
As you are traveling, count the number of cars with three occupants. These are the folks who are making a difference. Metrolink riders are doing their part every weekday to reduce traffic congestion, vehicle emissions and dependence on fossil fuels.
But there are other benefits beyond the fact that commuting by train is better for our environment: It's also less expensive and more relaxing than driving. I encourage everyone to consider Metrolink to meet his or her commuting needs.
Keith F. Millhouse,Moorpark
Don't hinder U.S. farming
Re: your May 19 article, "Residents concerned about chemicals":
The question that needs to be asked is, "Who was there first, the farmer or the housing development?" If the farmer was there first, then those who bought homes there had to know that he would be using pesticides, fumigants and fertilizers. That should have been taken into consideration before the home was purchased. To ask the farmer to change the way he grows crops just because residents moved in next door is really unfair.
We are losing more and more farmland and importing more and more produce over which we have no control as to how it is grown
We all saw what happened with the importation of wheat products from China. Now, I understand that toothpaste shipped to the Caribbean Islands from China is tainted with anti-freeze.
We must allow our farmers to grow crops in the United States with the controls we have over them, or we will have more of the "wheat from China" debacle.
Yvonne DiFrancesco,Moorpark
Subscribe to the Ventura County Star
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
You`ve got to run to win the race
Go along the way and quick the pace
So remember when you`re worried faith is fallin` down
That you got to bear a cross if you want to wear a crown.
Our Lord is testing us each day
He`ll try us out in every way
So don`t dispair when burdens fall around
You got to bear a cross if you want to wear a crown.
--- Instrumental ---
We`ve seen some men rise to the top
Then fall apart if they should drop
They can`t live on without their wealth
They blame the Lord above and they never blame themselves.
Out of these fallen some will rise
Accept their fate and realize
That their own trial to God they`ll hear the trumpet sound
That you got to bear the cross if you want to wear a crown...
George Glenn Jones (September 12, 1931 – April 26, 2013) was an American musician, singer and songwriter who achieved international fame for his long list of hit records, including "White Lightning", as well as his distinctive voice and phrasing. For the last 20 years of his life, Jones was frequently referred to as the greatest living country singer. Country music scholar Bill C. Malone writes, "For the two or three minutes consumed by a song, Jones immerses himself so completely in its lyrics, and in the mood it conveys, that the listener can scarcely avoid becoming similarly involved." Waylon Jennings expressed a similar opinion in his song "It's Alright": "If we all could sound like we wanted to, we'd all sound like George Jones." The shape of his nose and facial features earned Jones the nickname "The Possum."
Artist similar to George Jones:
Register to update information, save favorites, post photos, news stories and comments.


text:
- Subscribe
- Magazine
- Contract Packaging
- Education
- Leaders in Packaging
- Calendar
- Jobs
Download this free, 140-page Flexible Packaging Playbook jam-packed with strategies for success, best practices, and pitfalls to avoid. Learn more »
Article | June 30, 2003
Pouches stand up to retorting (sidebar)
Graphic statements
Certain package design elements are optional while others are required. Artwork on the pouch shows examples of both types.
One element—back-panel graphics including an illustration of the state of California—comes courtesy of another state: Minnesota.
"The reason we did it like that was that Minnesota has very strict labeling laws" says Fall River general manager Hiram Oilar. "We had to plainly state that this was a product of California. It was felt that the clearest way to do that was by putting a drawing of the state right on the bag."
Within the state's outline is copy about the Fall River Valley area where the rice is grown. A red dot points out the area's location on the map.
Another redesigned element is intended to cut through consumer confusion.
"The pillow packs were printed with copy that states 'fully cooked ready to serve'" says Oilar "yet even in in-store demonstrations people weren't getting it. They'd ask 'How long do I cook it?' so we knew the message was not getting through. We changed the new packaging so it reads 'Ready in 2 min.' on the front panel which seemed to appeal better to people."
See the story that goes with this sidebar: Pouches stand up to retorting
Related Sponsored Content
44 Best Package Designs
Sign up to receive timely updates from our editors and download this e-book of our editors' selections for most innovative package designs of the past year.


text:
- Main
- Submit Free Press Release
- List of 70+ Free PR Sites
- PR Resources
- Our Services
- News Type
- eBooks
- About Us
- Contact Us
Home ›
As hydraulic fracturing is increasingly used for oil and gas extraction across much of the United States and Western Canada, a new Ceres report issued today shows that much of this activity is happening in arid, water stressed regions, creating significan
The report provides first-ever data on oil & gas companies' water use and exposure to the most water stressed regions, including those in Texas, Colorado and California. It includes recommendations for companies to improve their water management and reduce their overall exposure to water sourcing risks.
"Hydraulic fracturing is increasing competitive pressures for water in some of the country's most water-stressed and drought-ridden regions," said Ceres President Mindy Lubber, in announcing Hydraulic Fracturing and Water Stress: Water Demand by the Numbers. "Barring stiffer water-use regulations and improved on-the-ground practices, the industry's water needs in many regions are on a collision course with other water users, especially agriculture and municipal water use. Investors and banks providing capital for hydraulic fracturing should be recognizing these water sourcing risks and pressing oil and gas companies on their strategies for dealing with them."
The report is based on water use data from 39,294 oil and gas wells reported to FracFocus.org from January 2011 through May 2013 and water stress indicator maps developed by the World Resources Institute (WRI). It shows that nearly half of the wells were in regions with high or extremely high water stress. (Extreme high water stress regions, as defined by WRI, are areas where 80 percent of available surface and groundwater are already allocated to municipal, industrial and agricultural users.)
The report spotlights eight specific regions with the most intense shale development and water stress challenges in the U.S. and Canada. It showed that over 55 percent of the wells hydraulically fractured were in areas experiencing drought and 36 percent overlay regions with significant groundwater depletion – key among those, California which is in the midst of a historic drought and Texas, which has the highest concentration of shale energy development and hydraulic fracturing activity in the U.S.
"Groundwater is simply not as plentiful as it used to be. We now recognize many competing uses – domestic, agricultural, for energy production and for the environment," said Jay Famiglietti, professor and director Earth System Science, Civil and Environmental Engineering, University of California, Irvine. "Ceres' report helps us confront difficult decisions about how we might allocate future waters, in particular in regions of considerable water stress."
In Texas, which includes the rapidly developing Eagle Ford and Permian Basin shale plays, more than half (52 percent) of the wells were in high or extreme high water stress areas. In Colorado and California, 97 and 96 percent of the wells, respectively, were in regions with high or extremely high water stress. Nearly comparable trends were also shown in New Mexico, Utah and Wyoming.
Among hundreds of hydraulic fracturing companies whose water use was evaluated, those with the highest exposure to water sourcing risk are Anadarako (APC), Encana (ECA), Pioneer (PXD) and Apache (APA). Most of the wells being developed by each of these companies are in regions of high or extreme water stress. The top three service providers, Halliburton, (HAL) Schlumberger (SLB) and Baker Hughes (BHI), handled about half of the water used for hydraulic fracturing nationally and also face water sourcing risks.
Although water use for hydraulic fracturing is often less than two percent of state water demands, the impacts can be large at the local level, sometimes exceeding the water used by all of the residents in a county. In many shale plays, hydraulic fracturing activity was found to be highly localized in a just few counties. Twenty-eight percent of water used in the regions studied was used in just two percent (or 10) of the counties where hydraulic fracturing took place. Dimmit County, Texas in the Eagle Ford basin had the largest volume of water use for hydraulic fracturing nationally – about four billion gallons. Garfield and Weld counties in Colorado and Karnes County in Texas were the highest water use counties in regions with extreme water stress.
Among the report's other key findings:
Texas: Texas is ground zero for water availability risks. Hydraulic fracturing-related water use is projected to double there over the next decade even as much of the state continues to face severe drought conditions, key groundwater aquifers are under stress and population growth is surging.
The Eagle Ford faces some of the biggest water challenges nationally. The amount of water used for hydraulic fracturing in this shale play is greater than in any other shale play or basin in the country (19.2 billion gallons from January 2011 to May 2013). Water use per well is also relatively high, averaging over 4.5 million gallons. Shale energy production is placing increased pressure on the counties of Dimmit, Zavala, and La Salle, which have seen groundwater levels decline as much as 100 to 300 feet the last several decades.
The Permian Basin also faces high water competition, groundwater depletion and drought concerns. More than 85 percent of the Permian's wells are in extreme water stress areas. Although average water use per well is much lower than in the Eagle Ford, the sheer number of wells in development is substantially larger, with over 9,300 wells reported developed since the beginning of 2011.
Colorado: The Denver-Julesburg Basin, part of the Niobrara shale formation, is another region with intense shale activity, much of it centered in Weld County, with nearly 2,900 wells developed since 2011 and an area marked by extreme water stress. Water demand for hydraulic fracturing in the state is forecast to double, to six billion gallons by 2015, more than twice what the city of Boulder uses in an entire year.
In California, nearly all of hydraulic fracturing water use is taking place in regions of extreme high water stress, although water use per well remains low. Most of the activity to date in California has been in Kern County, which is exposed to extreme high water stress due to factors such as large agriculture water demand and a growing population.
Many of the smaller shale plays (between 100 to 2,000 wells) are also in high and extreme high water stress regions, including the Piceance, Uinta, Green River, San Juan, Cleveland/Tonkawa and Anadarko Woodford basins.
"While the economic benefits of hydraulic fracturing are compelling, we must address all competing interests, particularly in relation to water use. For that we need factual data we can rely on to make informed decisions to ensure future water availability," said Amanda Brock, CEO at Water Standard, a Houston-based global water treatment specialist firm.
The report also includes key recommendations for investors and shale energy companies for mitigating their water sourcing risks. Shale energy operators should:
- Disclose to regulators, investors and other stakeholders: total water volumes and sources used in each shale play, future sourcing needs, and plans for reducing water use; breakdown of present and future use from freshwater and non-freshwater sources; volume of water returning to the surface, revenues and future growth in water stressed regions.
- Implement Operational Practices to minimize water use; collaborate with industry peers and other industries on local water sourcing challenges; develop local source water protection plans; minimize the use of aquifer exemptions and deep well injection disposal sites whenever feasible.
- Engage with Stakeholders, including with: local communities on water needs and challenges before starting operations and after they begin; local and regional regulators on water challenges; employees and suppliers to provide incentives for reducing water use.
- Embed water risk and opportunity across all business units, from the boardroom to the drill site.
"Water sourcing and management is becoming a key competitive advantage – and a critical risk – for oil and gas companies using hydraulic fracturing to unlock new reserves. Investors need the data to understand how companies are meeting these challenges on a regional or play-by-play basis in order to appropriately value companies and also engage with them to improve their practices, " said Steven Heim, Managing Director and Director of ESG Research and Shareholder Engagement at Boston Common Asset Management.
The report includes 3 interactive maps showing locations of hydraulically fractured wells against water stress, drought and groundwater depletion. See www.ceres.org/shalemaps
About Ceres
Ceres is a nonprofit organization mobilizing business and investor leadership on climate change, water scarcity and other sustainability challenges. Ceres directs the Investor Network on Climate Risk (INCR), a network of over 100 institutional investors with collective assets totaling more than $12 trillion. Ceres also directs Business for Innovative Climate & Energy Policy (BICEP), an advocacy coalition of nearly 30 businesses committed to working with policy makers to pass meaningful energy and climate legislation. For more information, visit http://www.ceres.org or follow on Twitter .
News Source : As hydraulic fracturing is increasingly used for oil and gas extraction across much of the United States and Western Canada, a new Ceres report issued today shows that much of this activity is happening in arid, water stressed regions, creating significant long-term water sourcing risks for companies operating in these regions as well as their investors.
Copy this html code to your website/blog to embed this press release.
More User Press Releases
More Ceres Press Release...
- Ceres Applauds Governor Snyder's Commitment to Comply with EPA's Clean Power Plan
- Join Ceres and Skytop Strategies for the Symposium on Water & Long-Term Value
- Symantec, Levi Strauss & Co., Mars, Dignity Health, and Autodesk Join Dozens of Companies Supporting California's Sweeping Climate Change Bills
- Leading Global Investors Urge Food and Beverage Companies to Better Manage Water Risks
- Investors Applaud EPA's Methane Emissions Rule
- Water Connection Charges: A Tool for Encouraging Water-Efficient Growth
- Most Water Utilities Missing Opportunity to Stretch Water Supplies
- 18 Michigan Companies and Investors Urge Gov. Snyder's Timely Implementation of EPA's Clean Power Plan
- 41 Colorado Businesses and Investors Urge Gov. Hickenlooper's Timely Implementation of EPA's Clean Power Plan
- 24 Ohio Companies and Investors Urge Gov. Kasich's Timely Implementation of EPA's Clean Power Plan
This press release is licensed under a Creative Commons Attribution 3.0 Unported License. Read full copyright information here.
Like this site on Facebook
Distribute Press Release
User login
Shopping cart
View your shopping cart.
Like/Save/Share Page
More like this
- How Much Water Does U.S. Fracking Really Use?
- Residual hydraulic fracturing water not a risk to groundwater
- New Report: Water and Climate Risks Are a Growing Threat to U.S. Corn Production
- Bureau of Economic Geology
- Participation in Tight Oil Development Project in Texas, USA
- EDF Statement on EPA's Water Study of Hydraulic Fracturing for Oil and Gas
- Shale Resources and Water Risks
- U.S. Forest Service keeps Virginia open to energy investment
- Water Management at Forefront of Exploration and Production Operators' Considerations, Says New IHS Study
- US natural gas output in June breaks daily record
Primary Menu
- News by Region
- Business
- List of Industries
- Technology
- Aerospace & Defense
- Agriculture & Forestry
- Arts
- Automotive
- Business Services
- Chemicals
- Construction & Maintenance
- Consumer Goods
- Education
- Energy
- Entertainment
- Food & Related Products
- General Business
- Government
- Healthcare
- Heavy Industry
- Home
- Industrial Goods & Services
- Industrial Materials
- Mining & Drilling
- Publishing & Printing
- Retail
- Society
- Sports
- Supermarkets
- Textiles & Nonwovens
- Transportation & Logistics
- Travel & Hospitality
- Wholesale


text:
Nine Tailed Fox
This series is not yet available on DramaFever.
Nine Tailed FoxStarring Kim Tae Hee and Jo Hyun Jae
Shi Yeon is a Nine-Tailed Fox living undercover in the human world. By day, Shi Yeon is an employee at a natural history museum. By night, she's a top-ranking woman warrior in the Nine-Tailed Fox clan, charged with preserving the delicate balance between man and fox. But her world is sent spinning when an atrocious serial murder - where the victims have had their internal organs gouged out - is uncovered. Detective Min Woo believes the murders may relate to the organ trafficking trade, and goes undercover in a seedy organ smuggling ring. But Min Woo's cover is blown, and it's only through the intervention Nine-Tailed Fox warrior Mu Young and Shi Yeon that he's able to survive! But he's seen their true identities as Nine-Tailed Foxes…can he be allowed to live? Source (Drama Wiki)
Leave a Review
Please sign in to comment.Log in / Sign up
No episodes have been released for this series.
Cast MembersShow All Show Less
Kim Tae Heeas Yoon Shi-yeon
Jo Hyun Jaeas Inspector Kang Min-woo
Jun Jinas Moo-young
Han Ye Seulas Chae-yi
Park Joon Sukas Rang
Uhm Tae Woongas Sa-joon
Lee Hwi Hyangas Senator Shin Soo-jang
Dok Go Young Jaeas Bureau Chief Jang
Kwon Hae Hyoas Inspector Moon
Lee Sang Inas Kim Young-mo
Latest Casting NewsShow all
- Lee Dong Wook cast in Bubblegum
- So Ji Sub cast in Oh My God
- Kim Soo Hyun cast in Producer
- Park Shin Hye cast in Heirs
- Lee Min Ho cast in Gangnam Blues
- Kim Woo Bin cast in Twenty
- Joo Won cast in Yong Pal
- Choi Si Won cast in She Was Pretty
- Lee Joon Ki cast in The Scholar Who Walks the Night
- Park Chan Yeol cast in EXO Next Door
- Jung Eun Ji cast in Cheer Up!
- Kim Jong Kook cast in Running Man


text:
Jason Paltrowitz,
Vice President,
Tel +1-212-815-2077,
Fax +1-212-815-3004,
About XTL Biopharmaceuticals Ltd.
XTL Biopharmaceuticals Ltd. ("XTL") is engaged in the development of therapeutics for the treatment of neuropathic pain and hepatitis C. XTL is developing Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropathic pain. XTL is also developing several novel pre-clinical hepatitis C small molecule inhibitors. XTL also has an active in-licensing and acquisition program designed to identify and acquire additional drug candidates. XTL is publicly traded on the NASDAQ and Tel-Aviv Stock Exchanges (NASDAQ: XTLB; TASE: XTL).
Cautionary Statement
Some of the statements included in this press release, particularly
those anticipating continued undisrupted trading of the Company's ADRs on
NASDAQ and similar matters, may be forward-looking statements that involve
a number of risks and uncertainties. For those statements, we claim the
protection of the safe harbor for forward-looking statements contained in
the Private Securities Litigation Reform Act of 1995. Risk factors that
could adversely affect our operations are identified from time to time in
our reports filed with the Securities and Exchange Commission, including
our annual report on Form 20-F filed with the Securities and Exchange
Commission on March 23, 2007. Any forward-looking statements set forth in
this press release speak only as of the date of this press release. We do
not intend to update any of these forward-looking statements to reflect
events or circumstances that occur after the date hereo
|SOURCE XTL Biopharmaceuticals Ltd
Copyright©2007 PR Newswire.
All rights reserved


text:
The August retail sales and consumer price reports smelled like gasoline. And like gasoline fumes, the high gas prices that lifted both will fade, says Stuart Hoffman of PNC Financial, leaving us with a "scrawny" economy that the Fed cannot save on its own.
MarketWatch News Break Get email alerts
Retail sales and inflation gains went into a tank
More News from MarketWatch
Top Stories
MarketWatch Partner Center
We Want to Hear from You
Join the conversation


text:
To embed, copy and paste the code into your website or blog:
The complaint in the now somewhat famous case.
Commentary regarding the summary judgment ruling, S&L Vitamins v. Australian Gold, 521 F. Supp. 2d 188 (E.D.N.Y. 2007), can be found at http://blog.ericgoldman.org/archives/2007/10/yet_another_ny.htm and elsewhere.
For information regarding the final outcome of the litigation, see http://www.jdsupra.com/legalnews/to-whom-it-may-concern-response-to-i-61076/.
Firefox recommends the PDF Plugin for Mac OS X for viewing PDF documents in your browser.
We can also show you Legal Updates using the Google Viewer; however, you will need to be logged into Google Docs to view them.
Please choose one of the above to proceed!
LOADING PDF: If there are any problems, click here to download the file.
Reference Info:Pleadings | Federal, 2nd Circuit, New York | United States
See more
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
© Ronald Coleman, Archer & Greiner, PC
Your first step to building a free, personalized, morning email brief covering pertinent authors and topics on JD Supra:
Sign up to create your digest using LinkedIn*
Back to Top
Copyright ©