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Let me set the scene for you. I was riding home from fire practice Sunday night on my Xtracycle loaded with about 40lbs of fire performance gear. It was about 12:20 AM and the sky was overcast, so any trace of the moon was lost. I was on an area of the road where there weren't many street lamps (Pima Rd between Rosemont and Craycroft, closer to Rosemont, for any Tucsonans). A wrong way cyclist was heading towards me sans light, reflector, helmet, and good judgement.
I screamed "Look out, look out!"
He gave me a bewildered look.
I decided that I would go as far right as possible, despite the almost nonexistant traffic conditions. I figure that I should get my body trained to stay to the right for the next time I encounter a nudnik like this.
He must have felt that he didn't want to give up right of way to some nudnik riding legally, as I felt I didn't want to give it up to some nudnik riding illegally, thus we collided.
Apparently, the Gravity Advantage JuJu that Xtracycle touts works...either that or physics are real. My extra stability and momentum made me hardly even veer off course, while his bike was thrown to the ground. When I looked back, I saw he was standing, so I figure he's okay.
I high tailed it out of there in case he wanted revenge. Besides, I wanted some sprint training.


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I recently purchased a hard-cover photo book from Blurb authored by a member on another forum.
I'm pleased with the overall quality and appearance. The photos are all b&w, and reproduced quite nicely.
The binding is neat and secure. The dust jacket is heavy and quite professional in appearance.
Just one man's opinion, worth every cent you paid for it.
- Leigh

subset: commoncrawl


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Becca Skinner
Photograph by Rebecca Skinner
Photograph by John Lloyd
Birthplace: Denver, Colorado
Current City: Laramie, Wyoming
What did you want to be when you were growing up?
I grew up always knowing that I wanted to explore.
How did you get started in your field of work?
In the fall of 2010, I won a grant from my university to travel to New Orleans to photograph the five-year difference from Hurricane Katrina. That trip was really life-changing, and it started turning the wheels that maybe photography is something that I would like to do for the rest of my life.
What inspires you to dedicate your life to photography?
Studying social work in school has made me really passionate about giving a voice to people who feel they cannot be heard. Through both my tsunami and Hurricane Katrina photo projects, I've realized that post-natural disaster communities are often forgotten about or pushed aside in wake of more recent news stories. I strongly believe that how a community recovers (or does not recover) is just as important as the disaster itself. Photographically documenting these communities and individuals seems to give personal stories and experiences a voice through an artistic and tangible venue.
What's a normal day like for you?
The only thing consistent in my life currently is that I like to drink a large cup of coffee every morning. Past that, I tend to stay away from routines.
Do you have a hero?
My uncle, Todd Skinner, who was a professional rock climber. He always encouraged us to push our own limits, to explore the wild places of the Earth, and to be a storyteller. He once said, "You cannot lower the mountain, therefore, you must elevate yourself." Those words have been ingrained in my mind since I first heard them. Also, I might be biased, but I have the most incredible parents in the world. Their endless support and love amazes me.
What has been your favorite experience in the field?
The most challenging? My favorite field experience thus far was getting to fly a kite (that looked like an American flag) in the middle of a rice paddy with all the villagers that we had been living with while in Sumatra. The sun was setting and everyone was laughing and trying to communicate even though we were speaking two different languages. It was like something I've dreamed or read about in books.
The most challenging part was trying to photographically document seven years of rebuilding in one short month of being in Banda Aceh, Indonesia. There has been so much happening in the area within that time, at times it seemed incredibly overwhelming to try and capture it all. I owe a serious "thank you" to my expedition partner, Chris Michael, for helping document all our experiences during our time there.
What are your other passions?
I grew up rock climbing, so I really enjoy being in the mountains. I also love biking and traveling. In my house, we have replaced the television with a bunch of instruments, so on any given day you could find me playing music with friends, too. I have a dog, Vedauwoo, named after the climbing area here in Laramie, who I spend a lot of time with as well.
What do you do in your free time?
Between balancing school and working two jobs, I don't have a lot of free time. But when I do find myself able to, I try to go take photos just for fun—not for any specific purpose but my own enjoyment.
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Photographically documenting these communities and individuals seems to give personal stories and experiences a voice through an artistic and tangible venue.
Becca Skinner
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This is Brian Ashcroft's Typepad Profile.
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Brian Ashcroft
Emeritus Professor in Economics and Editor of Economic Commentary, Fraser of Allander Institute, University of Strathclyde
Interests: Scottish economy, devolution, economic forecasting, regional economics and policy, Scottish media, macro-economic policy, public finance, acoustic guitar playing, Newcastle United
Recent Activity
I Overview In the latest Economic Commentary we note that the Scottish and UK economies are continuing to grow and recover from the Great Recession. With growth of 0.6% in the final quarter of last year – the latest data point - the Scottish economy has now enjoyed positive growth... Continue reading
Posted Jun 30, 2015 at Scottish Economy Watch
More on the Scotland on Sunday news story and my article, which is also included in my last post. My paper criticises recent work by Scottish Government economists in the Office of the Chief Economic Adviser (OCEA), which purports to show that increased productivity, investment and exports will raise the... Continue reading
Posted Mar 15, 2015 at Scottish Economy Watch
The news story in Scotland on Sunday about my article is here. The article itself does not appear to be on the Scotland on Sunday website yet, so here it is: On March 9th the Scottish Government published a news release "Greater gains from more fiscal control" The release claimed... Continue reading
Posted Mar 15, 2015 at Scottish Economy Watch
The latest Government Expenditure and Revenue Scotland (GERS) published today with data for 2013-14 is hardly a revelation. Scotland is shown to have a net fiscal deficit of -8.1% of GDP - when a geographical share of oil revenues is assigned to Scotland - while the UK deficit is -5.6%.... Continue reading
Posted Mar 11, 2015 at Scottish Economy Watch
In the latest Fraser Economic Commentary we discuss the threat to the Scottish and UK economies of the UK Coalition's current plans to increase the pace and scale of austerity over the next 4 years. The Institute for Fiscal Studies in their IFS Green Budget 2015 highlight the scale of... Continue reading
The underlying basis for the estimate in Fraser of Allander Institute's latest Economic Commentary that the fall in the price of oil could raise Scottish GDP growth is given in the box below: Continue reading
Our latest Economic Commentary, which was published today can be accessed here. A summary of our findings and forecasts is provide below: Overview The Scottish and UK economies are now recovering at a reasonable rate from the greatest economic shock since the 1930s. This recovery, slowed by the UK Coalition... Continue reading
The latest labour market data for Scotland, which were the subject of yesterday's post allow us to examine the type of jobs that are on offer, or are being taken up, in current conditions. The chart below shows where we are. In general terms, what we see is a shift... Continue reading
Posted Feb 20, 2015 at Scottish Economy Watch
Following the release yesterday (18 February) of the latest labour market statistics the Deputy First Minister and Cabinet Secretary for Finance, John Swinney, is reported as claiming that: "Scotland is outperforming the UK on all three headline labour market indicators with employment continuing to increase and unemployment down …." While... Continue reading
Posted Feb 19, 2015 at Scottish Economy Watch
The recent significant fall in world oil prices raises several issues and questions. One crucial issue is whether the low price will be sustained. If not, through, for example Saudia Arabia cutting back on production, then any effect on economic activity will be short lived. But it is now clear... Continue reading
Posted Dec 22, 2014 at Scottish Economy Watch
On November 12th, we published our latest Fraser of Allander Institute Economic Commentary, - sponsored by PWC. On the same day, the Scottish Government published its quarterly accounts for the second quarter under the Scottish National Accounts Project (SNAP). The Commentary, therefore, could only analyse the drivers of Scotland's economic... Continue reading
Posted Nov 27, 2014 at Scottish Economy Watch
Overview • In the latest Economic Commentary we note that in the first half of the year the Scottish economy delivered strong economic growth, increased job creation and falling unemployment. • However, there are signs that growth may be beginning to slow. Growth in the wider global economy and the... Continue reading
Posted Nov 13, 2014 at Scottish Economy Watch
In an earlier post I sought to establish the number of jobs that could be said to depend on economic links with the rest of the UK (rUK). That work suggested that almost 1 million jobs – 962,000 – were linked to the UK through rUK owned firms operating establishments... Continue reading
Posted Aug 25, 2014 at Scottish Economy Watch
The strong growth demonstrated in the latest GDP figures for Scotland is clearly to be welcomed. Welcome too is the attainment of the pre-recession peak, finally, after six years. However, what has pulled me out from under the olive trees and the hot Tuscan sun to write this blog is... Continue reading
Posted Jul 17, 2014 at Scottish Economy Watch
Using the latest data available from the Scottish Government we can examine Scottish growth over the last 50 years. This blog updates an earlier post in February 2012 here. The key points are: Scottish GDP growth over almost 50 years is comparable to UK growth – a little lower in... Continue reading
Posted Jun 23, 2014 at Scottish Economy Watch
The Institute's latest Economic Commentary on the Scottish economy, sponsored by PriceWaterhouseCoopers, is published here. In summary: Overview The Scottish economy is now enjoying a strong recovery. However, the Institute cautions that the recovery is subject to the risks of: a continuing unbalanced recovery; falling real wages; booming house prices... Continue reading
Posted Jun 23, 2014 at Scottish Economy Watch
The IMF has sought fit to effectively apologise for seeking last year to encourage the Chancellor to relax his austerity measures. Yes, they got the strength of the UK recent recovery wrong, everyone did, even Osborne himself. The Chancellor had quietly started to relax the austerity programme after 2012 as... Continue reading
Posted Jun 7, 2014 at Scottish Economy Watch
The latest Scottish new business statistics published by the Committee of Scottish Bankers (CSCB) today continues to show little sign of a pick up in new businesses in Scotland. I have graphed the latest data in the following chart: Despite the recovery, the number of new businesses continues to fall.... Continue reading
Posted Jun 6, 2014 at Scottish Economy Watch
Some time ago someone asked me in the context of the referendum debate: "How many jobs in Scotland depend on links with the UK?" I said: "I don't know but I can attempt to find out. But the harder question is determining how many of these jobs might be at... Continue reading
Posted Jun 3, 2014 at Scottish Economy Watch
The debate about the prospects for the public finances in an independent Scotland is intensifying. I sympathise with the views of Simon Schama, Martin Wolf and Tyler Cowan that the debate about Scottish independence should be dealing in higher things. As Wolf puts it The debate over the future of... Continue reading
Posted May 31, 2014 at Scottish Economy Watch
David Cameron is correct. (I never thought I'd write that sentence!) London is an asset for Scotland. Specifically, Cameron is reported in the Scotsman as saying "London is an enormous and precious asset for the whole of the UK, and many Scots benefit from London's hub status and from working... Continue reading
Posted May 20, 2014 at Scottish Economy Watch
The latest Scottish and UK regional labour market data published by ONS today reveal a continuing and now strong recovery in the Scottish labour market. Over 29,000 jobs were created in the quarter Oct-Dec 2013 to Jan-Mar 2014 and more than 67,000 jobs created over the year. Unemployment fell by... Continue reading
Posted May 14, 2014 at Scottish Economy Watch
Step back from the detail of Chancellor George Osborne's Budget today and ask yourself: Does this Budget help the economy to move to a sustained recovery? Remember we have an economy which is largely recovering on the back of household demand, which is built on shaky foundations: a falling savings... Continue reading
Posted Mar 19, 2014 at Scottish Economy Watch
Scottish economic growth continues to improve but the recovery could be threatened by imbalances in both the Scottish and UK economies according to our latest Economic Commentary sponsored by PricewaterhouseCoopers LLP. The recovery is being driven by household consumption, activity in the service sector and part-time and self employment. Growth... Continue reading
Posted Mar 14, 2014 at Scottish Economy Watch
The publication today of Government Expenditure and Revenue Scotland 2014 (GERS) provides information on Scotland's fiscal position in 2012-13 with revisions for earlier years. The document is obviously important since it is the last one in the series before the independence referendum on 18 September. What is the prospective voter... Continue reading
Posted Mar 12, 2014 at Scottish Economy Watch


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Millennial Media to Present at Upcoming Investor Conferences Business Wire BALTIMORE -- May 23, 2013 Millennial Media, Inc. (NYSE: MM), the independent leader in mobile advertising, today announced that company management will present at the following upcoming conferences: *The Cowen and Company 41^st Annual Technology, Media & Telecom Conference to be held at The New York Palace Hotel in New York City on Thursday, May 30, 2013 at 2:45 PM ET *The Needham 8^th Annual Internet & Digital Media Conference to be held at The Westin New York Grand Central Hotel in New York City on Tuesday, June 4, 2013 at 3:30 PM ET A live audio webcast of the presentations will be available on Millennial Media's investor relations website at: http://investors.millennialmedia.com. About Millennial Media Millennial Media is the leading independent mobile advertising and data platform. Our technology, tools and services help app developers and mobile website publishers maximize their advertising revenue, acquire users and gain audience insights. Our platform also enables us to offer advertisers powerful Mobile Audience Solutions (MAS) that utilize our significant scale, sophisticated targeting and uniquely engaging creative capabilities to deliver meaningful results. Contact: Millennial Media, Inc. Investor Relations Jonathan Schaffer, 212-871-3953 firstname.lastname@example.com or Matthew Lindberg, 203-682-8214 firstname.lastname@example.com
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In fact, the study found that 91 percent of high school vending machines sell at least some unhealthy foods.
The study also found that a la carte food and beverage options were served in 71 percent, 92 percent, and 93 percent of elementary, middle and high schools, respectively. Almost 80 percent of these options were determined to be unhealthful.
In 75 percent of high schools, students weren't allowed to leave campus during lunch. Yet less than half of all the elementary, middle, or high schools surveyed had a "wellness policy" in place, or took advantage of a government-sponsored fruit and vegetable program. And less than 20 percent of schools offered children the option to buy a low-fat lunch, the study found.
But, Alice H. Lichtenstein, director of the Cardiovascular Nutrition Lab at Tufts University's USDA Human Nutrition Research Center in Boston, said the findings need to be put into perspective.
"I think we put an overemphasis on the food students can access in school, because the majority of a teen's waking hours is not spent in school," she said. "But in any case, comparing elementary school children and high school children is comparing apples and oranges. They're two very different groups of students.
"High school students spend a lot more time in school," Lichtenstein added. "And they have more disposable income. So it's not surprising that they're going to be offered more vending machines. So, yes, it would be nice if in all public schools everything in them would be healthy choices. But I'm not sure that this comparison gets at particularly good information."
More information
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For over 30 years, INTECSEA has helped clients plan, develop and execute challenging offshore oil and gas projects worldwide. INTECSEA teams have designed subsea production systems, pipelines and floating systems in the harshest environments, and in locations as diverse as the Black Sea, Arctic Ocean, Mediterranean, Gulf of Mexico, offshore West Africa and the South China Sea.
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The long-term mission to better protect children in Indiana from abuse and neglect is in danger of becoming just another political argument that divides Hoosiers along partisan lines.
It's crucial for the sake of thousands of vulnerable children in our state that such an outcome isn't allowed to occur.
Democrats, from gubernatorial candidate John Gregg to contenders for legislative seats, have tried to turn the perceived failures of the Department of Child Services into a campaign issue used to discredit Republicans.
Although ideas for improving DCS certainly would be a welcome part of the political dialogue, most of the rhetoric to date hasn't gone beyond sound bite-style barbs. Much of the criticism also ignores recent history.
In 2004, Indiana suffered under one of the worst child protection systems in the nation. Case managers carried workloads that far exceeded national recommendations. Training was haphazard and, for some caseworkers, nonexistent. The annual turnover rate among child abuse investigators was 39 percent. The official number of child deaths from abuse and neglect in Indiana that year was 56, but an Indianapolis Star investigation in 2005 revealed that 66 children -- a record number -- had actually died. The investigation also found that the state had underreported deaths for several years in part because Indiana lacked a consistent standard for tracking abuse and neglect among its 92 counties.
Things began to improve in 2005 after the Department of Child Services was created, and an additional 800 caseworkers were hired. Caseloads were reduced and training became more uniform and regular. Perhaps as a result, the number of child deaths dropped to 25 by 2010.
Does that mean all of the problems are solved? Of course not. Not even close.
And that's where many Republicans have it wrong.
Instead of acknowledging up front that there's still a lot of work to do to better protect Indiana's children, Republicans have tended to be defensive, seeking to brush aside, among other concerns, questions raised about the number of children who suffer abuse after they're identified as at risk by DCS.
The percentage of children who are abused even after they're known by the system is alarming. Indiana's "re-abuse" rate of 8 percent hasn't changed much since 2004, and it's well above the federal standard of 5.4 percent. In fact, only 12 states have a higher rate than Indiana.
Is that Mitch Daniels' fault? Probably not. And it's certainly not something to pin on Mike Pence or Republicans in the General Assembly. But neither should they be in denial of the problems that still plague Indiana's children.
Let's agree that there's not a Democratic or Republican answer to the complex challenge of better protecting our children. Let's also agree to set aside partisan attempts to score points during an election cycle on an issue that deserves far more respect and thoughtfulness.
The truth is Indiana has made welcome progress in recent years in helping safeguard children from abuse and neglect. Yet, we still have a long, long way to go.


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|Disagreement Kind
|E6 6a
|Low in the grade but serious climbing. Start up Sweethope Crack to the roof and pull direct around this to gain a superb jug. Climb the areete to the break, step up and reach the faint arete continue up this.
Richard Davies 11/Sep/1988
Submit a new photo of this climb.


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Trubion retains the right to develop and commercialize, on its own or with others, product candidates directed to all targets not included within the agreement, including CD37.
About Trubion
Trubion is a biopharmaceutical company that is creating a pipeline of novel protein therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer. The company's mission is to develop a variety of first-in-class and best-in-class product candidates, customized for optimal safety, efficacy, and convenience that it believes may offer improved patient experiences. Trubion's current product candidates are novel single-chain protein, or SMIP(TM), therapeutics, and are designed using its custom drug assembly technology. Trubion's product pipeline includes CD20-directed candidates such as TRU-015 and SBI-087 for autoimmune and inflammatory diseases, developed under the company's Wyeth collaboration. Trubion's product pipeline also includes Trubion's proprietary product candidate, TRU-016, a novel CD37-targeted therapy for the treatment of B-cell malignancies that is currently in Phase 1/2 clinical evaluation. In addition to Trubion's current product candidates, the company is also developing additional alliance and proprietary product candidates that build on its product development experience. More information is available in the investors section of Trubion's website: investors.trubion.com.
Forward-Looking Statements
Certain statements in this release may constitute "forward-looking
statements" within the meaning of Section 21E of the Securities Exchange
Act of 1934 and Section 27A of the Securities Act of 1933. These statements
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Campaign Crawlers
Making the Old Right New
Ron Paul faces very long odds -- and big, young crowds.
ARLINGTON, Virginia -- It's not unusual to see 300 young professionals and college students lined up trying to get into a Clarendon bar and grille on a Thursday evening. But last week, the crowd wasn't there (just) for a night of beers and camaraderie -- they had come out to see Ron Paul, the ten-term Texas congressman and maverick candidate for the Republican presidential nomination.
Also on hand were camera crews from ABC News and C-Span. Nobody seemed more surprised by the attention than the candidate himself. "I asked how many people belonged to this club," he told the mostly standing-room anti-statists, "and they said 'oh, about 35 people.' I'm used to speaking for little groups of 35 people."
Now Paul is getting used to speaking to crowds as large as the 2,000 people who came out to hear him talk about fiat money -- no joke -- and foreign policy at Michigan State. There's hardly an Internet poll he hasn't won and his campaign beat expectations by raising nearly $5.1 million in the third quarter, putting Paul within a Mike Huckabee of John McCain. If Paul isn't yet a frontrunner, he is at least a cult favorite.
Paul is much more at ease in front of a friendly audience than at the Republican presidential debates, where he must answer questions with Rudy Giuliani cackling in the background and trade elbows with his more hawkish rivals over the Iraq war. He smiles cheerfully and even shows flashes of wry humor. ("We're not going to get rid of the Federal Reserve in a day -- it'll take two or three days.")
And Paul couldn't have asked for a friendlier audience. The event was organized by the Robert Taft Club, a group of young, D.C.-based paleoconservatives (full disclosure: I was paid a modest fee to speak at a past meeting). They applauded each time he called for abolishing a government program or closing a military base overseas, and prefaced questions with, "When you become president..."
Paul's real goal may be even more audacious than trying to get to the White House -- reviving an older conservatism that is more skeptical of military interventions and restoring the Robert Taft wing of the Republican Party. Paul admits that the latter more or less died with Senator Taft during the Eisenhower administration, though he sees the Facebook friends who come out to support him on the campaign trail as proof it can be resurrected.
Even Congress's libertarian happy antiwarrior must know this is a tall order. In a year where the Republican primary ballot will feature a tax-cutting pro-choicer and a tax-hiking pro-lifer, Paul could have plausibly run as a fusionist candidate. An implacable foe of both the IRS and abortion, he would shutter more federal agencies than Republicans dared dream in 1994 while marrying social conservatism to consistent federalism.
Paul praises his following as "diverse," but says they can get along because they "want to leave each other alone," a throwback to the pro-gun, anti-tax Leave Us Alone coalition that has since been supplanted by national greatness conservatism. He animatedly invokes the Constitution and American Revolution as he promises, "I don't want to run your life. I don't want to run the economy... I don't know how."
BUT THE BIGGGEST SINGLE driver of Paul's support in this campaign is also what limits his appeal to conventional Republicans -- his passionate opposition to the Iraq war and what he describes as the "illegal, unwise, unconstitutional military adventurism" of the Bush administration. The title of his talk was "A Conservative Foreign Policy," but no amount of readings from Taft or Russell Kirk can alter the fact that most people who today call themselves conservatives would regard Paul's preferred foreign policy as naive, even dangerous.
In addition to withdrawing from Iraq as quickly as possible, Paul would shed American commitments in Europe, Asia, and throughout the world, spending the savings at home -- as a down payment on the transition costs away from the welfare state. He casually drops the phrase "military-industrial complex," which, though used by Eisenhower, is usually associated with the post-McGovern left. What many Republicans consider essential to U.S. security in an age of terrorism, Paul dismisses as "war propaganda."
For this reason, GOP presidential candidates have been quick to use Paul as a foil for demonstrating their own toughness. And Paul's backers don't much like the rest of the field. Anti-Giuliani cracks abounded; a South Carolina supporter urged Paul to challenge Huckabee to a fight for questioning the Texan's commitment to national security. Paul beamed but demurred, saying, "I sorta like nonviolence." Asked what his administration would do to help rebuild Iraq, Paul said he'd favor such expenditures if he could only tax "the neocons" and "war supporters" to pay for them.
Since that taxable group still includes a majority of Republicans, can Paul gain traction? His supporters hope for a breakthrough in New Hampshire, which has a libertarian streak, or Iowa, where according to one poll 51 percent of Republicans want to leave Iraq within six months.
Basking in the applause of intense young paleos and libertarians, Paul didn't seem worried about what would happen to his own campaign. "I am not the greatest orator," he acknowledged. "But this is the greatest message."
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BackgroundGrim Fandango takes place in the Land of the Dead, where people go when they die. Once there, you have to embark on a four-year journey to reach your final resting place.
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Grim Fandango to be remastered for PS4 and Vita, all with Disney and LucasArts' blessing
Grim Fandango is, without argument, one of the best and most significant adventure games ever... posted Jun 10, 14 12:01am
Fancidanci and 7 others own Grim Fandango
raul7_7 and 4 others played Grim Fandango
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What's funny about death?: Grim fandango.
So in Grim fandango you are a travelling agent "Manny Calavera", who is stuck in the...
- Genre: Fantasy Adventure (PC)
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Released North America Sep 30, 1998


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Wherever you are, whatever you're doing, however much time you've got, you can help to tackle the arms fair today. The most important thing you can do is simply to speak out by telling someone about the fair and why you oppose it.


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By Tyler Kimmel - For the Cal Times
Cal U has always had plenty of sports for students to participate in. There are a wide variety to choose from for men, but women have not been left out.
There are multiple women's club sports including as cheerleading, dance, and even fencing. One sport has been missing on the women's side until now, Lacrosse.
A lacrosse team was a disturbing absence from the university for Virginia Tinkey and Catherine Rhodes. They decided to start a women's lacrosse club team for Cal U. "I wanted a lacrosse team at Cal so I could continue playing lacrosse, and for other girls to experience the sport," President Virginia Tinkey said.
This wasn't the first time the idea of a women's lacrosse team has surfaced at Cal.
"This was an idea that was brought up last semester and then brought up again by Virginia this semester," Vice President Catherine Rhodes said. "At the end of Spring 2011, we had about 35 girls interested. We are hoping to increase that number this semester."
The two are focusing on generating more interest for the team this semester. They are trying to add more girls to the club in order to get it up and running for the spring semester and many more to come.
"I hope to start a successful club that will stay on campus and become recognized by other colleges and universities and help the sport grow," Tinkey said.
Field hockey is similar to lacrosse and is another sport Cal does not offer. It is a popular high school sport for girls, however; Rhodes felt lacrosse was the better bet for success at Cal. "Lacrosse seems to be more popular among girls here," she said. "Lacrosse is also a spring sport whereas field hockey is in the fall."
Rhodes and Tinkey are hoping a lacrosse team will help girls grow as a person and not just an athlete. The goal is for the girls to learn from each other and help lay the foundation for a successful program. "I love teaching my skills to other girls and just as long as everyone is having fun, learning the skills, and becoming a team, I consider that being very successful," Tinkey said.
The main goal for the rest of this semester is to get enough girls to field a team. Players don't even need any prior experience, just a good attitude and a competitive spirit.
"The beauty of the lacrosse club is that no prior experience is needed," Rhodes said. "I have never played but I am excited to learn."
In order for the club to being this spring, more members are needed as soon as possible. Any girls that are interested in joining the women's lacrosse club team should attend a meeting Tues. Oct. 25 at 11 a.m. in the Vulcan Theater.


text:
Narrow your search
The Mio Knight Rider GPS is a portable navigation device like no other, featuring the voice of KITT, but behind all the fun, you'll also find a solid, entry-level in-car GPS.
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ThinkGeek's KITT car USB charger will make you think you're Michael Knight without having to unnecessarily jump a bridge or get a perm.
A mod adds a skill tree, looting, and tons of XP bonuses to make GTA 5 more like an RPG.
There are a lot of excellent titles leaving Netflix in July, so find out what to watch before they disappear.
Thank you, Kickstarter. Our dreams of seeing David Hasselhoff do the splits, lean on a Lambo and ride a dinosaur have all come true.
Gore Verbinski is to steer a new film about autonomous vehicles racing each other -- with hilarious consequences.
Yes, you can now watch live shows on the app but only if you live in certain markets.
Tech companies have been trying to make smartwatches happen for decades. Luke Westaway argues that Google has a mountain to climb to make Android Wear the Next Big Thing.
Thanks to a Google joke, your celebrity photobomb dreams are inching closer to reality. So long as you only dream about David Hasselhoff.
Fujitsu's prototype automotive voice command system is just like Knight Rider, with slightly more directions to restaurants and slightly less duffing up baddies.


text:
My review
Inspired by Home Cooks
Original recipe yields 24 servings
Based on a 2,000 calorie dietSee full nutrition
I just threw this recipie together - very easy! I changed the creamer to a fat free version but other than that followed it to a "T". It was economical to make and the taste is pretty good, es...
I followed the recipe exactly except for using "less sugar" chocolate drink mix. I like this mix better than most that call for powdered milk because it has a stronger coffee flavor to me. In fa...


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NPR Newscast
4min 45sec
October 23, 2009 A billion people around the world practice Islam, yet many Muslims in the U.S. and abroad feel too many of the voices often representing the faith are extremists. Host Michel Martin speaks with Dalia Mogahed, executive director of the Gallup Center for Muslim studies, about a new television program titled, "Who Speaks for Islam?"
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October 23, 2009 The Vatican has announced a plan to make it easier for groups of Anglicans who are dissatisfied with their faith to join the Catholic Church. Host Michel Martin speaks with Michael Sean Winters, who writes a daily political blog for America, a Catholic weekly magazine. Winters discusses the Vatican's plan, and how it is being received.
<iframe src="http://www.npr.org/player/embed/114073429/114073421" width="100%" height="290" frameborder="0" scrolling="no">
October 16, 2009 Islamic law affects the way some Americans do business in the United States. According to Sharia law, a set up rules influenced by the Koran, lenders and lendees cannot charge or receive interest. That means U.S. Islamic banks take a higher risk when loaning money for homes or investing in mutual funds. However, the community says they make more money and have avoided the current economic downturn. Host Michel Martin speaks with Monem Salam, director of Islamic financing at Saturna Capital Corporation. Martin also speaks with Aslam Sherule, a Dallas resident, who just purchased a home through an Islamic mortgage broker.
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October 2, 2009 The problem of macho attitudes are prevalent in many cultures. Now, church leaders are trying to use the pulpit to teach men and women how to live in equal harmony. Host Michel Martin speaks with Bishop David Evans, the Pastor of Bethany Baptist Church, and Jose Gonzalez, founder of Semilla Ministries, and an elder with James River Community Church for more.
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September 25, 2009 As millions of Jews across the world prepare for the holy day of Yom Kippur, host Michel Martin speaks with the authors of Bending Toward the Sun. The book is a family memoir, co-written by mother and daughter Rita Lurie and Leslie Gilbert-Lurie, about Rita's harrowing story of survival during the Holocaust, and how that experience reverberates across generations of the family. Lurie's 14-year-old daughter Mikaela also joins the conversation.
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September 18, 2009 For many Muslims, the end of Ramadan and the celebration of Eid, which commemorates a month of fasting, is near. During the past 30 days, Aman Ali has traveled to a different New York City mosque each night to break his fast, and says he now has a better understanding of the diversity in New York's Muslim population. Also, Yusuf Misdaq tells how he kept a blog throughout the holy month, each day posting a new poem, song or online video that explores his belief in the meaning of Ramadan.
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September 17, 2009 Father Boyle, a Jesuit priest in Los Angeles, has worked for years to help young people get away from "la vida loca" the crazy gang life. He's the founder and director of two job training programs "Homeboy Industries" and the "Homegirl café." Guest host Mandalit del Barco talks to Father Boyle, who's known in the community as Father G, about his vision for helping young people and how he has made it a reality.
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August 28, 2009 The Southern Baptist Convention issued an apology for its earlier stance on slavery. The issue had split the Baptist church between north and south in 1845. But a century and a half later, in 1995, Southern Baptist officials formally renounced the church's support of slavery and segregation. Richard Land, former head of the Southern Baptist Christian Life Commission, gives more information on the historic apology.
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August 28, 2009 Pastor Lincoln Bingham's predominantly black church – St. Paul Missionary Baptist — was bursting at the seams. And Pastor Mark Payton's mostly white church — Shively Heights Baptist — was worried about its longtime viability because of an older congregation. So the two pastors did something few black and white churches have ever done: merge. Pastors Payton and Bingham talk about their newly unified congregation and their first integrated Sunday service.
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August 21, 2009 President Obama recently convened a conference call, on which he spoke to thousands of faith leaders about health care as a moral and ethical issue. Host Michel Martin speaks with David Brody, White House correspondent for the Christian Broadcasting Network, and the Rev. Cynthia Hale, of Ray of Hope Christian Church in Decatur, Georgia. The two discuss why affordable health care for every American family is a moral priority for many people of faith.
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August 14, 2009 A study by Trinity College in Connecticut reveals atheism is on the rise in the U.S. Host Michel Martin interviews Blair Scott, Founder of the North Alabama Free Thought Association to talk about what it means to be an atheist and how they're working to find acceptance in communities throughout the country.
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August 14, 2009 An overwhelming majority of American nuns and priests are 60 years or older and white. But a study released this week shows that an increasingly racially and ethnically diverse group of Roman Catholics is pursuing vocations in the faith. Sister Mary Bendyna, of the the Center for Applied Research in the Apostolate at Georgetown University, which conducted the recent study for the National Religious Vocation Conference, explains the trend.
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July 31, 2009 The Promise Keepers, a men's evangelical group, celebrates 20 years of ministry with their "A Time to Honor" conference. This year, for the first time, program coordinators have created special sessions aimed at both men and women. Promise Keepers President Raleigh Washington talks about his organization's mission and how the men see themselves as protectors of the women in their lives.
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July 10, 2009 The 76th Episcopal General Convention is underway in California, where clergy will deliberate whether to bless same-sex marriages, and if an informal ban on gay bishops can be dropped. Ed Little, the Episcopalian Bishop of Northern Indiana, and the Rev. Susan Russell of All Saints Episcopal Church in Pasadena, Calif., debate gays in service to the Episcopal church.
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June 19, 2009 The Southern Baptist Convention holds its annual meeting next week, where worshippers will consider a resolution recognizing President Barack Obama's election as an important step on the path to racial reconciliation. The religious denomination, which represents more than 16 million members, has long been at odds with much of the Democratic Party's ideology. The Rev. Dwight McKissic, a black Baptist pastor, and the Rev. Hershael York, a white Baptist pastor and theology professor, discuss the issue.
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The IBM® FlashSystem™ V840 delivers high performance, efficiency, and reliability for shared enterprise storage environments, while simplifying data management, improving data security, and preserving your investments in storage with advanced software-defined storage.
October 9, 2014 - Updated to include the new power supply option and GUI productivity enhancement information
Storage capacity and performance requirements are growing faster than ever before, and the costs of managing this growth are depleting more of the IT budget. IBM® FlashSystem™ V840 (FlashSystem V840) has changed the economics of today's data center by eliminating storage bottlenecks, and its software-defined storage features simplify data management, improve data security, and preserve your investments in storage.
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This material has not been submitted to any formal IBM test and is published AS IS. It has not been the subject of rigorous review. IBM assumes no responsibility for its accuracy or completeness. The use of this information or the implementation of any of these techniques is a client responsibility and depends upon the client's ability to evaluate and integrate them into the client's operational environment.


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AURORA — A 6-year-old boy was suspended from his school for three days after school officials say he told a girl "I'm sexy and I know it," a line from a popular song.
D'Avonte Meadows, a first-grader at Sable Elementary School in Aurora, is accused of sexual harassment and disrupting other students, according to a letter the school district sent to the boy's mother after he was sent home Wednesday.
School officials issued a statement saying they couldn't discuss the case, but they pointed out a school board policy that defines sexual harassment as any unwelcome sexual advance. There is no age limit.
The Aurora Police Department said it was not involved in the case because laws only cover children 10 and older.
The boy's mother, Stephanie Meadows, said her son doesn't know the meaning of sexual harassment. It's the second time her son has gotten in trouble for quoting the song, she said. The song by the duo LMFAO was at the top of Billboard's Hot 100 chart for two weeks in January.
"I'm just, I'm floored," Meadows told 7News. "They're going to look at him like he's a pervert. And it's like, that's not fair to him."
The Associated Press could not locate Meadows for comment.
Aurora Public Schools issued a statement saying it is trying to provide an equal learning environment for all students.
"We have policies and protocol in place to prevent any disruption to the learning environment. Due to privacy laws, we are unable to discuss appropriate disciplinary consequences about a specific student," wrote spokeswoman Paula Hans.
Denver attorney Craig Silverman said elementary school students have the same rights to free speech as adults as long as they understand and follow the rules. He said school policies should allow for exceptions.
"Sometimes when you go to a zero-tolerance policy, you end up with a zero-sense policy," he said.
The 6-year-old's suspension comes while the Colorado Legislature considers a measure that would create a task force to potentially give school administrators more discretion on how to discipline students and avoid automatic calls to police.


text:
Butch Jones and the Vols are pleased to welcome the newest member of #Team118, athlete Neiko Creamer. The freshman was cleared by the NCAA, has enrolled at UT and has joined the Vols.
Click here for the original story.
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Search the Collection
Sitter in 1 portrait
by Mayotte Magnus
Linda Mary Evans, Deaconess
Sitter in 1 portrait
Una Margaret Patricia Kroll; Linda Mary Evans
by Mayotte Magnus
bromide print, April 1977
NPG x18620
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the latest video from the super cool and completely lovely LADYHAWKE: she about to blow up everywhere.#17758
Latinotype is the first commercial chilean foundry. Offers new latino-american typefaces for a small price, with a high quality.#17755
These UnCut sheets of Smoke & Mirror Playing Cards designed by Si Scott were taken straight off the factory press of the United States Playing Card Company and are extremely limited. Each copy is signed by Dan and Dave.#17754
Eneloop Kairo Hand Warmer series is light, compact, simple, and still powerful enough to keep you warm for hours.#17750
everyone's been talking about steven meisel's shoot for vogue: but then there's the best of all... a limited edition puzzle art piece. 1000 signed works, find yours asap.#17743
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An advent calendar for Obama's inauguration from a former columnist at the Chicago Sun-Times. Great idea and a good way to channel your excitement for this big day...#17740
A collection of colorful, creative, and beautiful self-portraits by Lucia Holm.#17739
Collect 'em all! Elfa-bits, Easy Elf, Yule Tide, Santa Flush ... The 2008 Winstanley Holiday cards are everything you need to keep your holiday house stocked.#17731
Beautiful series of prints by Pietari Posti. Giant animals roaming around in the city!#17728
Richard Selesnick and Nicholas Kahn have been collaborating as Kahn/Selesnick since 1988 on a series of complex narrative photo-novellas and sculptural installations.#17712


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Deviant Art
Hate PotionHate Potion5 years ago in Other More Like This
I closed my eyes and put the vial to my lips the amount
carefully measured from what you suggested. I had
carefully gone where I knew someone I had a score
to settle with would be. I waited. Nothing seemed to
happen for almost ten minuets. The first thing i noticed
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my Brother walked into the hallway as usual accompanied
by his close friends. I pulled out my wand and stunned one
of his friends and jumped out of the way from a body bind
curse that had been sent my way. I ran back out used the
leg locker curse his other friend. Than I ran at my brother
blocking a stinging hex. I pulled his wand out of his hand
tossing it aside. Than I has pounding every inch if his skin
I could reach. I don't know who pulled me off of him But I
remember screaming that I would kill him and his friends
and I would use their own slytherin powers to do it. I'm
almost certain some
|Sta.sh Submit


text:
Other states also had scattered outages. Duke Energy said it had nearly 300 outages in Indiana, with few left in Ohio by early afternoon after scores were reported in the morning.
As the storm moved east, New England state highway departments were treating roads and getting ready to mobilize with snowfall forecasts of a foot or more that was expected to start falling late Wednesday and through Thursday.
"People are picking up salt and a lot of shovels today," said Andy Greenwood, an assistant manager at Aubuchon Hardware in Keene, N.H.
As usual, winter-sports enthusiasts welcomed the snow. At Smiling Hill Farm in Maine, Warren Knight was hoping for enough snow to allow the opening of trails.
"We watch the weather more carefully for cross-country skiing than we do for farming. And we're pretty diligent about farming. We're glued to the weather radio," said Knight, who described the weather at the 500-acre farm in Westbrook as being akin to the prizes in "Cracker Jacks — we don't know what we're going to get."
Behind the storm, Mississippi's governor declared states of emergency in eight counties with more than 25 people reported injured and 70 homes left damaged.
Cindy Williams, 56, stood near a home in McNeill, Miss., where its front had collapsed into a pile of wood and brick, a balcony and the porch ripped apart. Large oak trees were uprooted and winds sheared off treetops in a nearby grove. But she focused instead on the fact that all her family members had escaped harm.
"We are so thankful," she said. "God took care of us."
• Associated Press writers Rick Callahan and Charles Wilson in Indianapolis, Kelly P. Kissel in Little Rock, Ark.; Jim Van Anglen in Mobile, Ala.; Holbrook Mohr in Jackson, Miss.; Julie Carr Smyth and Mitch Stacy in Columbus, Ohio; Amanda Lee Myers in Cincinnati; David Dishneau in Hagerstown, Md.; Holly Ramer in Concord, N.H.; and David Sharp in Portland, Maine, contributed to this report.


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Theory updates a style staple with this super soft eyelet-trimmed white T-shirt. A relaxed fit and semi-sheer finish lend this brushed-jersey top the label's contemporary cool, making it the perfect partner to skinny jeans during the day or glamorous glitter-sprayed pants after hours.
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How male and female brains diverge is a hotly debated topic, but the study of model organisms points to differences that cannot be ignored.
Did Inbreeding Royals Evolve?
April 22, 2013|
A new study suggests that in the Spanish Habsburg royal family, natural selection may have diminished the most harmful effects of inbreeding.


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PHAIWA staff
Professor Mike Daube, Director
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Peter Martin
Peter is currently completing his prac placement at PHAIWA as part of his undergraduate Preventive Health studies at Notre Dame University. He contributes to the Local Government Survey and also assists with the MediaWatch and JournalWatch services.
PHAIWA also work closely with the McCusker Centre for Action on Alcohol and Youth
To contact the McCusker Centre, please see their website:


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Kids Stuff Academy
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About This School
Kids Stuff Academy is located in Anderson, SC. It is a preschool that serves children ages 0-7+. Kids Stuff Academy is Independent and has a capacity of 20 children.
Kids Stuff Academy offers instructional programs in reading and math.
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text:
Recent genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) and myocardial infarction (MI). The 9p21.3 locus was verified by numerous replication studies to be the first common locus for CAD and MI. In the present study, we investigated whether six single nucleotide polymorphisms (SNP) rs1333049, rs1333040, rs10757274, rs2383206, rs10757278, and rs2383207 representing the 9p21.3 locus were associated with the incidence of an acute MI in patients with the main focus on the familial aggregation of the disease.
The overall cohort consisted of 976 unrelated male patients presenting with an acute coronary syndrome (ACS) with ST-elevated (STEMI) as well as non-ST-elevated myocardial infarction (NSTEMI). Genotyping data of the investigated SNPs were generated and statistically analyzed in comparison to previously published findings of matchable control cohorts.
Statistical evaluation confirmed a highly significant association of all analyzed SNP's with the occurrence of MI (p < 0.0001; OR: 1.621-2.039). When only MI patients with a positive family disposition were comprised in the analysis a much stronger association of the accordant risk alleles with incident disease was found with odds ratios up to 2.769.
The findings in the present study confirmed a strong association of the 9p21.3 locus with MI particularly in patients with a positive family history thereby, emphasizing the pathogenic relevance of this locus as a common genetic cardiovascular risk factor.
In recent years, genome-wide association studies (GWAS) have displayed an effective approach to localize genomic regions predisposing to common, polygenetic disorders, including cardiovascular disorders[1,2]. By means of independent genome-wide association studies using single nucleotide polymorphism (SNP) arrays the first common chromosomal locus has been identified which confers susceptibility for coronary artery disease (CAD) and myocardial infarction (MI)[3-5]. Initially, the two SNPs rs10757274 and rs2383206 consistently associated with CAD were identified in a large scale study population of Caucasian origin[3]. Both polymorphisms are located within a locus spanning a 58-kilobase region on chromosome 9p21.3. Three additional SNPs, rs1333040, rs2383207, and rs10757278 on the 9p21.3 locus and in genetic disequilibrium were identified independently as being associated with MI[4]. Moreover, large-scale genome-wide association scans identified further polymorphisms, amongst others rs1333049, within the same genomic region to be associated with MI and CAD and therefore verified chromosome 9p21.3 as a susceptibility locus for the incidence of the disease[5,6]. Based on these findings, replication studies using case-control designs proved that the identified SNPs were associated with CAD and MI in a large variety of study population[7-17]. In all studies, the association of the 9p21.3 locus with CAD and MI was shown to be independent of conventional risk factors. In a subsequent study the association of the rs1333049 risk variant with the extend of CAD could be established[18]. Thus, even though the responsible gene in this region is still unknown, the 9p21.3 locus was verified to be the first common genetic factor affecting the risk of CAD and MI. Further studies may provide new insights into the impact of chromosome 9p21.3 on the pathogenesis of CAD and the occurrence of a MI.
In the present study the influence of six SNPs (rs1333049, rs1333040, rs10757274, rs2383206, rs10757278, and rs2383207) representing the 9p21.3 region on the occurrence of MI was investigated. The main focus of our investigation was on an association of the 9p21.3 locus with a positive family history of MI in a large cohort of patients presenting with an acute coronary syndrome (ACS).
Study subjects
Over a three year span (2004 to 2006), a total of 976 unrelated male patients younger than 65 years were enrolled into a study due to a symptomatic ACS with STEMI as well as NSTEMI. This prospective multi-centre registry involved four heart centres and six cardiologic departments in Germany. The study was approved by the ethical committee of the University Witten/Herdecke, Germany, and conformed to the declaration of Helsinki. All participants gave written informed consent to participation.
MI was defined as follows: ischemic type chest pain lasting for more than 20 minutes, at least 0.1 mV of ST-segment elevation in the limb leads and/or at least 0.2 mV elevation in the precordial leads and one of the following criteria: left bundle branch block, new Q wave (at least 0.03 s), elevated creatine kinase or positive troponin T or I. All cases underwent cardiac catheterization and interventional or surgical revascularization. Patients < 18 and > 65 years, with unstable angina or without central European origin were excluded from further studies.
Blood samples and DNA preparation
EDTA-blood samples were drawn from each participant at baseline ward round. Genomic DNA was extracted from 350 μl of these samples using the BioRobot EZ1 and the EZ1 blood extraction kit according to the manufacturer's instructions (QIAGEN; Hilden, Germany). DNA was quantified using the BioPhotometer (Eppendorf; Hamburg, Germany) and each sample was diluted to a final concentration of 25 ng/μl.
PCR amplification and genotyping
Genotyping of the investigated SNPs (rs1333049, rs1333040, rs10757274, rs2383206, rs10757276, and rs2383207) was carried out by real time PCR and subsequent melting curve analysis on a LightCycler 480 instrument (Roche Applied Science; Mannheim, Germany). The primers and hybridization probes were designed and synthesized by Tib MolBiol GmbH (Berlin, Germany). PCR was carried out in 96-well plates (Roche Applied Science; Mannheim, Germany) using 12.5 ng of genomic DNA as template in a final reaction volume of 5 μl. Reaction mixtures contained 0.5 μM of each primer, 0.15 μM of SNP-specific hybridization probes and 1 μl of LightCycler 480 Genotyping Master (Taq DNA polymerase, reaction buffer, 15 mM MgCl2, and a dNTP mixture with UTP instead of dTTP) (Roche Diagnostics GmbH, Mannheim, Germany).
The cycling program consisted of 10 minutes of initial denaturation at 95°C, followed by 35 cycles (rs1333049, rs2383206, rs2383207, rs10757274, rs10757278) or 40 cycles (rs1333040) of denaturation at 95°C for 5 seconds, annealing at 53°C (rs1333049, rs2383206, rs2383207), at 59°C (rs1333040) or at 62°C (rs10757274, rs10757278) for 10 seconds, and extension at 72°C for 10 seconds. After PCR melting curves were generated by holding the reaction mixture at 95°C for 1 minute, stepwise lowering of the temperature to 65°C, 55°C and 45°C, holding for 30 seconds at each temperature, lowering to 40°C for 2 minutes, followed by continuously heating to 75°C. Melting curve analyses were conducted using the LightCycler 480 software according to the manufacturer's instructions (Roche Diagnostics GmbH; Mannheim, Germany).
Statistical analysis
The distribution of genotypes and the allelic frequencies were investigated and analyzed by alignment to previously published data of applicable controls. Genotypes were tested for Hardy-Weinberg equilibrium among MI cases and controls using a chi-square test with one degree of freedom. Differences in the genotype distribution were tested for statistically significance and odds ratios (ORs) were determined using the 2-way contingency table chi-square test using a freely accessible program (http://statpages.org/ctab2x2.html webcite). For all data, the association was considered to be significant for p < 0.05.
A total of 976 patients, aged 24 to 65, were included into the present study to investigate the association between the 9p21.3 locus polymorphisms and acute MI. 72.8% of the ACS patients hospitalised with MI were diagnosed with ST-segment elevation (STEMI), 27.2% of the patients with non ST-segment elevation (NSTEMI). Of 976 patients 361 patients (37%) declared a positive family history of MI, defined as at least one first-degree relative affected before the age of 60 years, 404 patients (41.4%) had a negative family history, whereas 211 patients (21.6%) were not aware of another MI case in their family.
Controls were selected from previously published genotyping data. These data comprised subjects from Europe which were enrolled for independent studies as previously described elsewhere[3,4,11]. The baseline clinical characteristics and procedural parameters of the study population are presented in Table 1.
Table 1. Clinical characteristics of the study population
Replicated association of six variants on 9p21.3 with acute MI
Six SNPs on chromosome 9p21.3 were selected for genotyping based on strength of association in previous studies[3,4,11]. In order to confirm the reported association of the investigated SNPs with MI, genotyping data of the overall study cohort were compared to previously published data of control subjects (Table 2). All controls were without known history of CAD. Furthermore, only control cohorts were selected, which were comparable to the MI cases of the present study concerning geographic origin (northern and central Europe), age and wherever applicable, gender.
Table 2. Association of six variants on 9p21.3: MI study population vs. controls
The rs1333049 genotype distribution and allelic frequencies were compared to the data of the PopGen controls[11]. For analysing the data of rs1333040, rs10757278, and rs2383207 we used the controls of the Iceland B collectives [4] and for the analysis of rs2383206 and rs10757274 the Copenhagen City Heart Study (CCHS) controls[3]. The genotype distribution in MI cases and controls did not significantly (P > 0.1) deviate from the Hardy-Weinberg equilibrium.
As shown in table 2, a statistically significant difference in the distribution of genotypes of MI cases compared to controls was observed for all analyzed SNPs (p < 0.0001). Odds ratios determined for the respective high-risk homozygous alleles were in the range of 1.621 to 2.039. These findings verified the strong association of the 9p21.3 locus with MI in this large scale study population of male patients presented with ACS.
Variants on 9p21.3 are associated with a positive family history of MI
To investigate the association between the sequence variants and a positive family history of MI, patients with at least one first degree-relative who had suffered from a premature MI (n = 361) were selected and the genotype distribution and allelic frequencies for all variants were analyzed and compared with the data of the corresponding control cohorts (Table 3) and with the data of the patients without a positive family history (Table 4).
Table 3. Association of six variants on 9p21.3: MI study subpopulation with a positive family history vs. Controls
Table 4. Association of six variants on 9p21.3: MI study subpopulation with a positive family history vs. MI study subpopulation with a negative family history
Statistical analyses revealed odds ratios in the range of 1.892 to 2.769 for MI patients with a positive family history demonstrating a much stronger association than for the overall cohort of MI patients and therefore a considerable increased risk for MI patients with a family burden of the disease (Figure 1).
Figure 1. Homozygous Odds Ratios and 95% Confidence Intervals for the investigated SNPs. Boxes indicate the relative size of samples. Grey boxes indicate ORs and CIs for the overall cohort of MI patients, black boxes for patients represented with a positive family history.
These findings could be confirmed comparing MI patients with a positive family history with patients without a positive family history for all SNP variants with the exception of the rs1333040 SNP (Table 4).
These results could also be confirmed in an additional haplotype analysis (Figure 2). For the haplotypes GGGGC and AAAAG spanning the rs10757274, rs2383206, rs2383207, rs10757278, and rs1333049 SNPs a significant association of a positive vs. a negative family history could be shown (p = 0.0051 and p = 0.0087 respectively). Adjustment for other cardiovascular risk factors (smoking, body mass index, hypertension, diabetes mellitus and hyperlipidemia) revealed no higher frequencies of the risk variants within the 9p21.3 region in MI patients examined by means of subgroup analyses (data not shown). These findings emphasize this genetic region as a genetic risk factor for MI independent of other risk factors.
Figure 2. Haplotype analysis for the investigated SNPs. As can be seen, all SNPs with the exception of the rs1333040 show a positive association of the phenotype MI in the presents of a positive family history of the disease. The haplotypes GGGGC and AAAAG revealed the strongest association of MI with a positive family history.
In recent years, genome wide association studies focused on genomic factors involved in development of CAD and MI. In these studies and subsequent replication studies the 9p21.3 locus was found to be the most common locus associated with CAD and MI. Moreover, in a subsequent study, a strong association of the SNP rs1333049 representing the 9p21.3 risk variant with the extent of CAD could be shown[18].
In the present study, we investigated the association of six previously reported sequence variants representing the 9p21.3 locus in a large scale study population of male patients who had suffered from an acute MI. In this well defined study cohort, the exclusive inclusion of patients aged ≤ 65 years increased the probability that genetic factors are involved to a significant degree in the onset of MI. Moreover, only men were enrolled which excludes gender specific differences having an influence on the development of CHD. It is well known that women develop CHD about 10 years later than men, probably due to the protective effects of female sex hormones but also due to the different frequency of classical risk factors such as diabetes, hypertension and smoking habits[19,20].
Genotyping of the study population showed similar or even higher high-risk allele frequencies compared to those in previous studies which reported the association of 9p21.3 sequence variants with CHD and MI[3,4,11]. Comparison was carried out using previously cited control subjects from central or northern Europe and without a known history of CAD. Moreover, in the German PopGen study only men were used as control subjects[11]. Thus, the selected controls were comparable to the present MI cohort and therefore justifiably applied in the presented association analyses. Comparison of the data with control subjects revealed a statistical significant difference in the genotype distribution and allelic frequencies of all analyzed polymorphisms within the 9p21.3 region. The observed higher odds ratios are probably due to the much more homogeneity of the study cohort investigated in the present study. No significant difference was observed in the genotype distribution of our MI cases and MI patients from previous studies. Hence, we confirmed the association of this locus with MI in the present study cohort. This emphasises once more the relevance of this genetic factor in the pathogenesis of CAD and MI.
Having replicated the association of all investigated SNPs with MI, patients having definitively presented with positive family history of MI were selected and compared to the corresponding control cohorts or a subpopulation of patients with a definitively negative family history. For the accuracy of this analysis, patients who provided no information on a family history of MI were excluded. This analysis revealed a significantly stronger association in patients having presented with a positive family history of MI than in the overall cohort of MI patients with calculated odds ratios within the range of 1.892 to 2.769.
Classification according to a positive family history provides an improved risk prediction for the patients. In fact, the increased risk of carriers of the homozygous risk alleles and a positive family history is comparable to the increased risk of hypertensive patients (OR 1.91), patients with diabetes mellitus (OR 2.37) or current smokers (OR 2.87) calculated in a large case-control study of acute MI in 52 countries[21].
To our knowledge the present study is the first one to analyse the association of all six 9p21.3 SNPs with acute MI in relation to a positive family history. Indeed, few other studies reported the association with CAD after classification of patients according to their family history. However, our study differs from the others in the origin of the patients, in the strict inclusion criteria and in the larger number of patients. Moreover, the quantity of analyzed sequence variants in the present study was higher.
Our findings made evident the correlation between high-risk variants on the 9p21.3 locus and male patients with acute MI and a positive family history. Over the past few years, risk evaluation has exclusively been performed on the prevalence of classical risk factors such as age and gender, LDL-cholesterol, hypertension, diabetes mellitus, smoking habits, diet, a family history and physical activity[22,23]. The findings of the present study may help to improve risk assessment and early prevention particularly for patients with a positive family history of CAD when 9p21.3 sequence variants are taken into account.
Limitations of the study
One limitation of the study is the lack of an own control group. Using previous reported data about the allelic distribution of SNP's will be of a limited bias due to the fact, that thousands of chromosomes where analysed in previous reported studies. Another limitation is that not a consistent control group could be used for comparison.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
TS, MS, AH and GH have made substantial contributions to conception and design as well as analysis and interpretation of the data. KS and PB have made the genetic analyses. HRO, WS, JT, WM, F-JH, ChS, ThD, HG, HH, WD acquired patients and clinical data, TS and KS wrote the manuscript. All authors have read and approved the final version of the manuscript.
We would like to thank Kirsten Rackebrandt for technical assistance and Joanne Davies for technical assistance and linguistic corrections, and all co-workers in the participating centres of the "Forschungsverbund Herz-Kreislauf in NRW".
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Pre-publication history
The pre-publication history for this paper can be accessed here:


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Thank you for your interest in applying to the Writing Fellows program!
Becoming a Fellow is both an honor and a serious commitment. As you decide whether to apply, keep in mind that applicants to the Writing Fellows program must be currently enrolled UW-Madison students in good standing with the University. To be considered for the program, applicants must have at least two semesters remaining at the University. Students selected to be Fellows must enroll in a three-credit, writing-intensive honors seminar on tutoring writing across the curriculum This seminar examines fundamental theories about writing and provides a forum in which Fellows share their experiences as tutors and as writers.
All Writing Fellows (including those who are new to the Program) are assigned to work with a faculty member who is teaching a writing-intensive or Communications B course. Each Fellow assists 10-15 students in the class, reading drafts, giving thoughtful written feedback, and holding individual conferences with students to offer suggestions for revision. For their service, Writing Fellows receive an $1000 honorarium per semester.
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Prince Assistants to the Papal Throne
From Wikipedia, the free encyclopedia
(Redirected from Prince Assistant to the Papal Throne)
The Princes Assistant to the Pontifical Throne are hereditary offices of the Roman Curia. They date from the early sixteenth century and survived the reform of the Prefecture of the Pontifical Household in 1968. They are the only hereditary posts still in use at the Vatican.
There are two living holders of the title:
- Prince Don Alessandro Torlonia, Prince Torlonia, Prince of Fucino, Prince of Canino and Musignano
- Prince Don Marcantonio Colonna, Prince and Duke of Paliano
The head of the Colonna family has been one of the Princes Assistant since 1710. The head of the Orsini family was one of the Princes Assistant from 1735 to 1958 when Pope Pius XII removed the title from Prince Filippo Orsini who was having an affair with the actress Belinda Lee and then slashed his wrists.[1] Pius then appointed the head of the Torlonia family as the second Prince Assistant.
- ^ "Papal Prince's Title in Jeopardy", (29 January 1958) Independent, Long Beach, California, Access Newspaper Archive
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Re: Travelling from Volos to Athens
"...If I take the bus, apparently I will arrive at the bus station in Athens..."
You are talking about Kifisos KTEL Bus Station.
There is a public bus line connecting the airport with the Kifisos Intercity Bus (or KTEL) Station (central station for busses that run domestic routes all over the country), and this is the Express line E93. The bus runs every 35 minutes. The route duration from the airport to KTEL station is less than 1 h, depending on traffic load. Cost is about 3 euros. This is your first option.
"...If I take the train/rail I will arrive at the Larissa railway station and then take a metro to the airport..."
Correct. This is your second option. But take into account the following:
(Published in February 2009)
Dear passengers,
2009 will be a highly productive year for the Athens Metro, as in about a year from today nine new stations will be put into operation which will serve thousands of residents and workers living at very densely populated areas of Attica. The extensions at four fronts proceed with intensive pace, however since the 14th of February there must be a necessary 6-month suspension of operation at the section Ethniki Amina - Halandri - Doukissis Plakentias - Airport, in order to complete the construction works for the three in-between stations at Holargos, Nomismatokopeio and Aghia Paraskevi, which unfortunately were not delivered when the extension to the airport was put into operation in 2004.
The above discomfort which will last for 6 months is rendered unavoidable. However, we hope that the discomfort will be minimised, since the Hellenic Ministry for the Environment, Physical Planning and Public Works and the Hellenic Ministry of Transport & Communication, in cooperation with the Athens Urban Transport Organisation, Attiko Metro Operation Company S.A. (AMEL) and Attiko Metro S.A., have figured out the best possible solutions for the facilitation of the passengers traveling from Ethniki Amina towards the Airport. In August, the Nomismatokopeio station will be put into operation, simultaneously with the reinstatement of operation of this section of Line 3. At the end of 2009, the Holargos station will be put into operation along with a new parking area at Nomismatokopeio with a capacity for 630 vehicles. Finally, the Aghia Paraskevi station will be available for the passengers to use in the middle of 2010.
Possibly somebody more exrerienced can guide you about metro alternative solutions, but I think your first option (Kifisos KTEL bus station) is the best.
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Re: Travelling from Volos to Athens
the second way i think is better.you will arive at the train station in athens and you ll take metro for the airport.i think its faster.when you are in greece you can call 1110.its informations for the train schedule.
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Re: Travelling from Volos to Athens
Thank you for your thorough reply,
If I do take the KTEL Bus from Volos to Athens, is there a way that I can make reservations in advance (in English)? Also, do you know how long of a bus ride it is exactly from Volos to Athens?
Thank you for your time,
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Re: Travelling from Volos to Athens
There is a bus 12 times per day, travel time about 4.30' (320km). 5 of them are EXPRESS (faster).
http://www.ktelvolou.gr/ (but only in Greek language).
e-mail: email@example.com
tel. (Volos office) 2421033254, 2421025527.
Intercity train is 8 (or 10?) times per day, travel time 5.00 hours.
Sorry, I don't have more info.
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Opened 6 years ago
Closed 4 years ago
#1299 closed enhancement (fixed)
site wide activity widget should aware "rel" tag
|Reported by:
|Owned by:
|Component - Activity
I'd like to suggest site wide activity widget should allow "rel" tag for images,
it'll open up for image display plugin to work properly, such as lightbox or thickbox.
Attachments (1)
Change History (10)
comment:1 @apeatling — 6 years ago
- Milestone set to 1.2
- Type changed from enhancement to defect
Will add support for this in 1.2.
comment:2 @apeatling — 6 years ago
- Keywords needs-patch added
Need a patch for this.
comment:3 @apeatling — 6 years ago
- Milestone changed from 1.2 to 1.2.1
- Type changed from defect to enhancement
Bumping to 1.2.1.
comment:4 @boonebgorges — 5 years ago
- Component set to Core
- Milestone changed from 1.3 to 1.4
There is no sitewide activity widget in BP anymore, though I assume the issue is more broadly relevant.
Punting to 1.4 in the absence of a patch. If anyone wants to step up, please feel free to bump this back to 1.3.
comment:5 @DJPaul — 5 years ago
I assume this would just involve adding the rel tag to the bp_activity_filter_kses() filter? Easy props for someone if they would like to patch it.
comment:6 @masonjames — 4 years ago
- Owner set to masonjames
- Status changed from new to accepted
@masonjames — 4 years ago
Added 'rel' attribute to the activity filter
comment:7 @masonjames — 4 years ago
- Keywords has-patch added; needs-patch removed
- Resolution set to fixed
- Status changed from accepted to closed
Here's my first patch. Feel free to let me know if I've done it incorrectly :)
comment:8 @boonebgorges — 4 years ago
- Component changed from Core to Activity
- Milestone changed from 1.4 to 1.3
- Priority changed from major to minor
- Resolution fixed deleted
- Status changed from closed to reopened
Thanks for the patch, I'll have a look shortly.
comment:9 @boonebgorges — 4 years ago
- Resolution set to fixed
- Status changed from reopened to closed
Looks like this is already done in the trunk, as of r3494.