text:
Our best posts
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100 Most Upvoted Annotations of 2013
96. Kanye West – I'm In It 51 Upvotes
Then she came like AAAAAHHH!
96. Jay Z – Somewhereinamerica 51 Upvotes
Twerk, twerk (Miley, Miley)
Only in America
96. Just-Ice – Moshitup 51 Upvotes
Suicide it's a suicide buda bye bye
Suicide it's a suicide eh
Suicide it's a suicide buda bye bye
Suicide it's a suicide
96. Big Sean – Control 51 Upvotes
fuck y'all clubs
Fuck y'all pictures, your Instagram can gobble these nuts
96. Eminem – Berzerk 51 Upvotes
Lamar, oh sorry yo, we done both set the bar low
91. Drake – Started From The Bottom 52 Upvotes
Say I never struggled, wasn't hungry, yeah, I doubt it
91. Kanye West – New Slaves 52 Upvotes
New Slaves
91. Big Sean – Control 52 Upvotes
Mollies'll prolly turn these niggas to fucking Lindsay Lohan
A bunch of rich ass white girls looking for parties
91. Eminem – Berzerk 52 Upvotes
That's why my pen needs a pad cause my rhymes on the ra-aag
91. Eminem – Rap God 52 Upvotes
I'm beginning to feel like a Rap God, Rap God
All my people from the front to the back nod, back nod
Now who thinks their arms are long enough to slapbox, slapbox
88. Chance The Rapper – JUICE 53 Upvotes
88. Drake – 5AM in Toronto 53 Upvotes
You underestimated greatly
Most number ones ever, how long did it really take me?
88. Joey BADA$$ – Reign 53 Upvotes
[Fireworks Exploding]
83. Skrillex – First Of The Year (Equinox) 54 Upvotes
Aeg eh euf, gyaaaa uh ah uh, gye gye gye gyeeeeuw.
Aeg eh euf, gyaaaa uh ah uh, gyuh nyi nyi nyi nyiiii nyao ni ni ni.
Aeg eh euf, gyah, ah, yef, yaaiooiiiiinaaiiooneueuaodeh.
Aeg eh euf, gyaaaa uh ah uh, gye naowenyeeehuh.
Aeg eh euf, gyaaaa uh ah uh, gyuh nyi nao seddedum.
Aeg eh euf, gyah, ah, yef, giaoaiosoiiiiinaaiiooneueuayewnudeh.
83. A$AP Rocky – Fuckin' Problems 54 Upvotes
I love bad bitches, that's my fucking problem
83. Kanye West – New Slaves 54 Upvotes
My momma was raised in the era when
Clean water was only served to the fairer skin
83. Lupe Fiasco – SLR 2 54 Upvotes
It's hard being a Lupe fan, go to Harvard to be a Lupe stan
83. Eminem – Rap God 54 Upvotes
But for me to rap like a computer must be in my genes
I got a laptop in my back pocket
78. Pusha T – Doesn't Matter 55 Upvotes
Since y'all claim I'm Illuminati, tell me why would you try me?
Kennedy, John F., or Bobby
Almost caught Reagan, but they stopped us at the lobby
And that was broad day, so how the fuck you gon' stop me?
78. Kanye West – New Slaves 55 Upvotes
You see it's broke nigga racism
That's that "Don't touch anything in the store"
And it's rich nigga racism
That's that "Come in, please buy more"
78. Big Sean – Control 55 Upvotes
This the same flow that put the rap game on a crutch (West x6)
78. Eminem – Berzerk 55 Upvotes
But I done did enough codeine to knock Future into tomorrow
78. Eminem – So Much Better 55 Upvotes
I'm just playing bitch, you know I love you
71. Drake – Started From The Bottom 56 Upvotes
Started from the bottom now we're here
Started from the bottom now my whole team fuckin' here
Started from the bottom now we're here
Started from the bottom now the whole team here, nigga
Started from the bottom now we're here
Started from the bottom now my whole team here, nigga
Started from the bottom now we're here
Started from the bottom now the whole team fuckin' here
71. Tyler The Creator – Rusty 56 Upvotes
I'm harder than DJ Khaled playing the fucking quiet game
71. Kanye West – New Slaves 56 Upvotes
Teamed up with the CCA
71. Kanye West – Blood On The Leaves 56 Upvotes
Fuck them other niggas cause I'm down with my niggas
Fuck them other niggas cause I'm down with my niggas
Fuck them other niggas cause I'm down with my niggas
I ride with my niggas, I'd die for my…
71. Big Sean – Control 56 Upvotes
If Phil Jackson came back, still no coachin' me
I'm uncoachable, I'm unsociable,
71. Drake – Tuscan Leather 56 Upvotes
Self explanatory, you just here to spread the story, wassup
71. Eminem – Rap God 56 Upvotes
You witnessing a massacre
Like you watching a church gathering take place, lookin' boy
69. Robin Thicke – Blurred Lines 57 Upvotes
What rhymes with hug me?
69. Mac Miller – S.D.S. 57 Upvotes
I'm just an idea, nothing concrete
65. Wu-Tang Clan – C.R.E.A.M. 58 Upvotes
[Verse 1: Raekwon]
65. NYPD – Jay-Z File 58 Upvotes
65. Big Sean – Control 58 Upvotes
(I don't smoke crack, motherfucker I sell it!)
65. Earl Sweatshirt – 523 58 Upvotes
[Produced by RandomBlackDude]
62. Kanye West – New Slaves 59 Upvotes
I see the blood on the leaves
I see the blood on the leaves
I see the blood on the leaves
62. Eminem – Berzerk 59 Upvotes
Let's take it back to straight hip-hop and start it from scratch
62. Eminem – Rap God 59 Upvotes
59. A$AP Rocky – 1 Train 61 Upvotes
Bitch pussy smell like a penguin
Wouldn't hit that shit with my worst enemy's penis
59. Chance The Rapper – Smoke Again 61 Upvotes
Lean all on the square
That's a fuckin' rhombus
59. Kanye West – On Sight 61 Upvotes
He'll give us what we need
It may not be what we want
58. Tech N9ne – Fragile 62 Upvotes
This jam will lay scripted
56. Nas – Back When 63 Upvotes
But I don't sweat it, study long, study raw
My man Dion said Nas over-think the songs he writing
I'm not a wack performer standing near a corny hype man
56. Eminem – Survival 63 Upvotes
[Verse 1]
54. Kanye West – I Am a God 64 Upvotes
I just talked to Jesus
He said, "What up Yeezus?"
54. Eminem – Berzerk 64 Upvotes
Now this shit's about to kick off, this party looks wack
50. Kanye West – I'm In It 65 Upvotes
Uh, I be speaking Swaghili
50. Big Sean – Control 65 Upvotes
I'm usually homeboys with the same niggas I'm rhymin' with
But this is hip-hop and them niggas should know what time it is
50. Big Sean – Control 65 Upvotes
Eminem, Andre 3000, the rest of y'all
50. Eminem – Berzerk 65 Upvotes
All I know is I fell asleep and woke up in that Monte Carlo
48. Kanye West – Blood On The Leaves 66 Upvotes
[Intro: Nina Simone]
Strange fruit hanging from the poplar trees
Blood on the leaves
48. Big Sean – Control 66 Upvotes
I got love for you all but I'm tryna murder you niggas
46. Drake – All Me 67 Upvotes
Ho, shut the fuck up!
46. TDE – BET Cypher 2013 67 Upvotes
And tucked a sensitive rapper back in his pajama clothes
Ha-ha, joke's on you, high-five
43. Kanye West – I Am a God 70 Upvotes
In a French-ass restaurant
Hurry up with my damn croissants
43. Big Sean – Control 70 Upvotes
[Bridge: Kendrick Lamar]
43. Drake – All Me 70 Upvotes
I learn from what I've been through
41. Kanye West – Illest Motherfucker Alive 71 Upvotes
sponsored by Manolo
41. J. Cole – Power Trip 71 Upvotes
Got me up all night, all I'm singing is love songs
She got me up all night, constant drinking and love songs
She got me up all night, down and out with these love songs
She got me up all night, drown it out with these love songs
She got me up all night, all I'm singing is love songs
She got me up all night, constant drinking and love songs
She got me up all night, down and out with these love songs
She got me open all night, got me open all night
38. Lil Wayne – Trigger Finger 72 Upvotes
[Verse 3 – Soulja Boy]
38. Tyler The Creator – Lone 72 Upvotes
[Tyler]: Nah but if I seen that nigga I woulda killed him
38. Big Sean – Control 72 Upvotes
They don't wanna hear not one more noun or verb from you niggas
37. Eminem – Rap God 73 Upvotes
All my people from the front to the back nod, back nod
32. Kanye West – Mercy 76 Upvotes
32. Kanye West – New Slaves 76 Upvotes
Fuck you and your Hampton house
I'll fuck your Hampton spouse
Came on her Hampton blouse
And in her Hampton mouth
32. Eminem – Berzerk 76 Upvotes
Question is are you bozos smart enough to feel stupid
32. Drake – From Time 76 Upvotes
What's up?
Been a minute since we kicked it, you've been caught up
With them bitches,
32. TDE – BET Cypher 2013 76 Upvotes
I serve niggas like master Geoffrey
31. Jay Z – Somewhereinamerica 80 Upvotes
Feds still lurking
They see I'm still putting work in
Cause somewhere in America
Miley Cyrus is still twerkin'
29. Chance The Rapper – Acid Rain 82 Upvotes
my trees leafless
29. Kanye West – I Am a God 82 Upvotes
28. Kanye West – New Slaves 84 Upvotes
You see there's leaders and there's followers
But I'd rather be a dick than a swallower
27. Kanye West – Mercy 85 Upvotes
That white frost on that pound cake so your Duncan Hines is irrelevant
26. Schoolboy Q – Collard Greens 86 Upvotes
Translation: Ven aqui, mami, ese culo
Tu quiero coger mi huevos, y papi molestes pero
Chuparse puto pendejo, el pinche cabron
25. Mac Miller – S.D.S. 87 Upvotes
Wonder if Christ made a million off selling the cross
24. Big Sean – Control 89 Upvotes
I'm Makaveli's offspring, I'm the king of New York
King of the Coast, one hand, I juggle them both
23. Chance The Rapper – JUICE 91 Upvotes
But I love y'all souls
22. Kanye West – Hold On 92 Upvotes
21. Drake – 5AM in Toronto 95 Upvotes
I could load every gun with bullets that fire backwards
You probably wouldn't lose a single rapper
20. Lady Gaga – Do What U Want 96 Upvotes
Do what you want with me
What you want with my body
Do what you want with me
What you want with my body, girl
19. Childish Gambino – Centipede 98 Upvotes
Hey centipede, centipede, centipede…
17. Big Sean – Control 103 Upvotes
[Verse 2: Kendrick Lamar]
17. Kanye West – Mercy 103 Upvotes
Roll my weed on it, that's an ass tray
15. Lady Gaga – Do What U Want 105 Upvotes
Do what you want with me
What you want with my body, girl
Help me now
Do what you want with my body
Do what you want with my body…
15. Eminem – Bad Guy 105 Upvotes
I've been drivin' around your side of this town
Like nine frickin' hours and forty-five minutes now
14. Chance The Rapper – Favorite Song 106 Upvotes
This my jam, this my jam, this my jam, this my jam
I'm 'bout that jam, I'm 'bout that jam, I'm 'bout that jam, I'm 'bout that jam
This my jam, this my jam, this my jam, this my jam
I'm 'bout that jam, I'm 'bout that jam, I'm 'bout that jam, I'm bout that jam
13. Kendrick Lamar – Look Out For Detox 107 Upvotes
Tire marks, tire marks
Finish line with the tire marks
When the relay starts I'm a runaway slave
12. Wale – Bad 108 Upvotes
Is it bad that I never made love, no I never did it
But I sure know how to fuck
11. Rocko – U.O.E.N.O 113 Upvotes
Put Molly all in her champagne, she ain't even know it
I took her home and I enjoyed that, she ain't even know it
9. Eminem – Berzerk 114 Upvotes
Bout to go ham, ya bish, shout out to Kendrick
9. Drake – From Time 114 Upvotes
I love me, I love me enough for the both of us
8. Eminem – Rap God 116 Upvotes
Be a king, think not – why be a king when you can be a God
7. Big Sean – Control 144 Upvotes
You gon' get this rain like it's May weather
6. Kanye West – New Slaves 155 Upvotes
Teamed up with the CCA
5. Big Sean – Control 158 Upvotes
They say Detroit ain't got a chance, we ain't even got a mayor
4. Big Sean – Control 165 Upvotes
I'm trying to raise the bar high
Who tryna jump and get it? You're better off trying to skydive
Out the exit window of 5 G5's with 5 grand
With your granddad as the pilot he drunk as fuck trying land
With the hand full of arthritis and popping prosthetic leg
Bumpin Pac in the cockpit so the shit that pops in his head
Is an option of violence, someone heard the stewardess said
That your parachute is a latex condom hooked to a dread
3. Mac Miller – S.D.S. 172 Upvotes
If it's true, they should hit Alaska in an igloo
2. Drake – Started From The Bottom 230 Upvotes
We don't like to do too much explainin'
1. Big Sean – Control 284 Upvotes
And that goes for Jermaine Cole, Big KRIT, Wale
Pusha T, Meek Millz, A$AP Rocky, Drake
Big Sean, Jay Electron', Tyler, Mac Miller
Posted November 29th, 2013


text:
The New York Public Library redesigned their logo and changed to a sans serif font. The video outlines the evolution of their logo.#26200
Ryoji Ikeda's "Datamatics [ver. 2.0]" premiered in the US at Harvard last night. The beauty of lots of data!#26193
Book jacket design by Rachel Wells, a graphics student at Loughborough University. Some other nice projects too but this is my favourite!#26192
This wild, futuristic rally car concept generates additional power by an array of rear wings that harness kinetic energy.#26183
amazing realistic still lifes by Adam Stennett, which has a dark comparison between weapons and over the counter products.#26181
Sensual Dynamic, the Copenhagen chair is a beautiful piece of modern design, made in red and black fiber glass. Designed by Alvaro Uribe, and produced by Billes Products in New Orleans.#26176
A3+ Architects, an Italy based firm, just finished a finalist project for an urban renovation in Sicily. Light steel structures covered by natural ivy just link the historical center of the town with a big new square#26175
'Shot At From Both Sides' is an exhibition in Kentucky with street-art-inspired mixed-media pieces.#26171
Birds of a Feather Blog - A daily dose of inspirational imagery for you to enjoy and share one day at a time from photographers Lou Mora & Sarah Yates.#26160

subset: commoncrawl


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By Nicole Santa Cruz
Posted Oct. 8, 2015, 2:05 p.m.
About 9:45 p.m. Sept. 9, Joseph "Joey" Galvan left church, went home to change, then walked to a bus stop with a friend.
The friend went on to a convenience store, but Galvan stayed. He was due at work for the night shift at a warehouse in Compton.
At the bus stop, a man approached Galvan, and there was a brief struggle. The assailant pulled out a gun and shot Galvan, 22, in the head. He was just two blocks from his home. Los Angeles County Sheriff's Department officials said it's unknown why Galvan was shot.
On a recent weekend, people from his church and other houses of worship around Los Angeles County walked the streets of Carson to bring attention to Galvan's death.
The group marched with "Stop the violence" posters and photographs of Galvan. During the walk, one woman pointed out the blue ...
Continue reading »
By Jeanette Marantos
Posted Oct. 8, 2015
Eduardo Redolledo-Ramirez, a 33-year-old Latino male, died Tuesday, Oct. 6, after being shot in Canoga Park, according to Los Angeles County coroner's records.
Posted Oct. 3, 2015, 6 a.m.
It was one of the deadliest months in years in Los Angeles. The 39 reported homicides in August were spread across this sprawling city; all but two of the victims were male; all but eight were shot to death.
By Jerome Campbell
Posted Oct. 1, 2015, 3:41 p.m.
Kenya Gatling knew teenagers kept secrets from their parents. But deep down, she felt her son was different.
At 18, Marshawn Jackson still greeted Gatling with kisses on both cheeks. The two talked about his love life and fears. And since his brother, Deshawn Dixon, was fatally shot in 2013, they had spent many nights crying together in his room.
"You wouldn't expect a teenager to let his mom into his room, but he wanted me there," said Gatling, 41. "There was very few things that we didn't share with each other."
That's why she couldn't understand why Marshawn Jackson had decided not to attend a memorial on the anniversary of his brother's death Aug. 27.
"He said that he had to be somewhere at two o'clock, and I kept thinking, that's not like him," Gatling said. "I pressed him on it. He ...
By Veronica Rocha
Posted Sept. 29, 2015, 1:35 p.m.
Murder charges were filed Tuesday against two men in connection with the death of a 21-year-old UCLA student whose body was found inside a burning Los Angeles apartment a week ago.
Alberto Medina and Eric Marquez, both 22, each face one count of murder and two counts of burglary, according to a Los Angeles County Superior Court criminal complaint.
Medina is accused of burglarizing an apartment in the 10900 block of Roebling Street, then entering Andrea DelVesco's apartment and fatally stabbing her, according to the complaint.
Medina also faces a separate felony arson charge. He is accused of maliciously setting a fire inside DelVesco's apartment, according to the complaint filed by the Los Angeles County district attorney's office.
The pair are scheduled to be arraigned Tuesday afternoon in L.A. County Superior Court.
Los Angeles Police Chief Charlie Beck said there was a "considerable amount" of forensic ...
Posted Oct. 1, 2015
Jari Wayne, a 32-year-old white male, died Tuesday, Sept. 29, after being stabbed in Van Nuys, according to Los Angeles County coroner's records.
Posted Sept. 28, 2015, 7:21 p.m.
Two men were sentenced to life in prison last week in the fatal shooting of a 31-year-old man during a drug-deal-turned-robbery in a community college parking lot.
Raheen Ahab Taylor, 33, and Derrick Phillip Wilson, 27, two black men, were sentenced Sept. 24. A jury convicted Taylor and Wilson July 10 of first-degree murder, with the special allegation of murder in the commission of a robbery.
Taylor and Wilson were also convicted of three counts of second-degree robbery, according to a news release from the Los Angeles County district attorney's office.
Prosecutors said Taylor and Wilson were in a parking lot of Los Angeles Valley College in Valley Glen where they had agreed to purchase marijuana from three men, including Ricardo Zetino, 31.
During the meeting, however, Taylor and Wilson pulled out handguns and stole the drugs from the men.
Zetino was shot as he tried ...
Brian Lee Gomez, a 28-year-old Latino male, died Monday, Sept. 28, after being shot in Montebello, according to Los Angeles County coroner's records.
Posted Oct. 5, 2015
Eliazar Lunaquezadas, a 22-year-old Latino male, died Monday, Sept. 28, after being shot in Compton, according to Los Angeles County coroner's records.
Posted Sept. 28, 2015
Norma Guzman, a 37-year-old Latino female, died Sunday, Sept. 27, after being shot in Historic South-Central, according to Los Angeles County coroner's records.
Donta Jackson, a 20-year-old black male, died Sunday, Sept. 27, after being shot in Florence-Firestone, according to Los Angeles County coroner's records.
Deshawn Childs, a 38-year-old black male, died Saturday, Sept. 26, after being shot in Willowbrook, according to Los Angeles County coroner's records.
Tyrone Duran, a 42-year-old Latino male, died Saturday, Sept. 26, after being stabbed in Santa Fe Springs, according to Los Angeles County coroner's records.
Posted Sept. 25, 2015, 11:08 a.m.
A group of three men hugged each other as they marched toward the spot Todd James Britt was fatally shot.
The men had formed a deep bond with the 51-year-old, who had supported them through difficulty.
On Sept. 16 about 6 p.m. Britt was walking his dog in the 7900 block of South Normandie Avenue in Vermont Knolls when he was approached by a man who shot him.
Britt was taken to a hospital, where he was pronounced dead. He was the eighth person to be killed in Vermont Knolls this year, according to the Times Homicide Report database.
Last year, 12 people were killed in the area. Detectives do not have a motive and have not found any suspects.
On Sunday night, the men walked east on West 80th Street with others who had personal memories of Britt. Yet, these men claimed to know him best. The trio ...
Posted Sept. 25, 2015
Jose Ricardo Villela-Arroyo, a 30-year-old Latino male, died Thursday, Sept. 24, in Westlake, according to Los Angeles County coroner's records. The cause of death is pending.


text:
"If we can block km23-1, we can stop the spread of colon cancer earlier," Mulder said. "But we would also affect other important functions of the protein. In order to address this issue, we are now trying to find the specific partners of km23-1 that contribute to the invasion of the cancer cells. Then we can design more precise therapeutic agents that target critical regions of km23-1 rather than eliminating the entire protein."
Researchers used a cell model that represents a unique class of colon cancer that needs further study. This model features cells that move as groups, and not singularly.
"The type of cell movement, or migration, has important implications with respect to the detection of tumor cells in the blood of cancer patients, as well as for the development of new treatments," Mulder said.
|Contact: Matthew Solovey
Penn State


text:
HOPE for Bereaved, Inc. to host observance May 31
The HOPE for Bereaved, Inc. will be hosting a Memorial Day ceremony to remember those who have died recently and long ago, as well as those who have died will serving their country.
The organization's office, located at 4500 Onondaga Blvd in Syracuse, holds the mission of helping people cope with grief that occurs with a loss of a loved one.
Therese Schoeneck, HOPE founder and executive director, invites community members to attend and hear the words of local clergy and dignitaries at noon Monday May 31 at the Butterfly Garden off Onondaga Lake Parkway.
Spirit of Syracuse Chorale Group will perform a song for the ceremony.
Because the Butterfly Garden has many memorial bricks purchased by people across the region, Schoeneck said there is likely to be many people from all walks of like who will be at Monday's service.
"It's very powerful and peaceful," Schoeneck said.
The event is in its 19th year and has become tradition for many. Attending the event as she does year after year, Schoeneck said she will attend the ceremony and then grab a hotdog at Heid's with her daughter and other loved ones.
Parking at the garden will be more accessible as a parking area has been designated thanks to a recent Liverpool Rotary project.
Schoeneck said she wanted to thank HOPE member Jim Keib who reached out to the rotary after sharing the need for the sign.
The Green Thumb in Lafayette has also donated flowers to the garden for years, a business that Schoeneck said has been a solid support to the purpose.
If you are interested in volunteering at the garden, call Kim at 475-9675.
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Randolph Tabernacle
Randolph Tabernacle
The Randolph Tabernacle in 2010
|25 S. Main Street, Randolph, Utah
|41°39′55″N 111°11′6″W / 41.66528°N 111.18500°WCoordinates: 41°39′55″N 111°11′6″W / 41.66528°N 111.18500°W
|John C. Gray
|Architectural style
|Victorian Eclectic
|Governing body
|The Church of Jesus Christ of Latter-day Saints
|NRHP Reference #
|Added to NRHP
|April 10, 1986[1]
The Randolph Tabernacle is a Victorian-styled meetinghouse for the Randolph Ward (congregation) of the The Church of Jesus Christ of Latter-day Saints (LDS Church) and is located in Randolph, Rich County, Utah. It was listed on the National Register of Historic Places on April 10, 1986.
On July 5, 1898, after the creation of the Woodruff Stake, it was decided to build a large meetinghouse for the Randolph Ward that could accommodate people from small outlying communities.[2] Given that the meetinghouse was to be built and used primarily by the Randolph Ward (one congregation) and not multiple congregations within the Woodruff Stake, it is technically not a tabernacle, but a meetinghouse,[3] though its size and elaborate architectural style may be why it has been known colloquially as the Randolph Tabernacle. Members of the Randolph Ward provided almost all of the cost of the building,[4] which by some estimates was around $24,000. The brick walls were complete by 1901 and the roof was finished in 1902. In November 1904, the building was in usable condition and the first meeting was held. The two-story tower was completed in 1909. The building was dedicated on July 26, 1914, by then-LDS Apostle George Albert Smith. The architect, John C. Gray, also served as the bishop of Randolph Ward from 1901-1921.
Minor renovations occurred in 1936 and 1977. An extensive renovation took place between 1984-1985, which included a large rear addition for classrooms, a cultural hall, and offices.[5] The meetinghouse remains in use by the Randolph Ward.
- ^ "National Register of Historic Places". NPS Focus. National Park Service. Retrieved 2010-04-12.
- ^ http://pdfhost.focus.nps.gov/docs/NRHP/Text/86000724.pdf
- ^ http://www.deseretnews.com/article/705384920/The-churchs-tabernacle-building-tradition.html?pg=2
- ^ http://pdfhost.focus.nps.gov/docs/NRHP/Text/86000724.pdf
- ^ http://pdfhost.focus.nps.gov/docs/NRHP/Text/86000724.pdf
External links[edit]
- Media related to Randolph Tabernacle at Wikimedia Commons
- 20th-century Latter Day Saint church buildings
- Buildings and structures in Rich County, Utah
- Meetinghouses of The Church of Jesus Christ of Latter-day Saints in Utah
- Properties of religious function on the National Register of Historic Places in Utah
- Religious buildings completed in 1914
- Tabernacles of The Church of Jesus Christ of Latter-day Saints in Utah
- Victorian architecture in Utah


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President Barack Obama, flanked by Vice President Joe Biden and House Speaker John Boehner of Ohio, gestures as he gives his State of the Union address during a joint session of Congress on Capitol Hill in Washington on Feb. 12.
- Filed Under
STANDING OVATION: When President Barack Obama gave his State of the Union address, Vice President Joe Biden clapped, smiled and rose to just about everything Obama said. Not quite so much for House Speaker John Boehner. He wasn't brainwashed by the speech like Biden was. How can Obama cut the deficit when he plans to visit Israel soon and hand it a $3 billion check? I don't think that makes much sense.
Dennis Zemple,


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Community meetings are being planned in Oklahoma City, Tulsa and possibly Clinton to pass on information and answer questions, he said.
"I think the policy took a lot of courage on the part of the president," Brooks-Jimenez said. "Both sides, Republicans and Democrats, seemed to historically favor the DREAM Act, but it never made it to the floor for consideration."
Lawmakers say policy is political
U.S. Rep. Tom Cole, R-Moore called the move transparently political.
"The appropriate way to deal with this issue is to propose legislation," Cole said. "Instead, the president has chosen to act unilaterally and inappropriately."
"This new immigration policy is another effort to receive votes during an election year, as it prevents the deportation of individuals who moved to the United States illegally," said U.S. Sen. Jim Inhofe, R-Tulsa. "However, this comes as no great surprise, as it is not the first time this administration has openly shown contempt for our nation's immigration laws."
U.S. Rep. John Sullivan, R-Tulsa, said the president is granting amnesty to millions of illegal immigrants instead of putting American citizens back to work.
"Make no mistake about it, this is nothing but a political maneuver designed to appease his liberal base and get re-elected — but it's not going to work" Sullivan said. "This backdoor DREAM Act is against the will of the American people and is in direct violation of the rule of law."
The move comes in an election year in which the Hispanic vote could be critical in swing states like Colorado, Nevada and Florida.
Activist opposing Obama's deportation policies last week mounted a hunger strike at an Obama campaign headquarters in Denver, and other protests were planned this weekend.
Huerta has become in activist for the DREAM Act and a member of the Oklahoma City chapter supporting it. During her recent college graduation ceremony, she walked across the stage with the word "undocumented" on the back of her gown.
She and more than a dozen others fighting for the DREAM Act met Friday afternoon at La Oaxaquena bakery in south Oklahoma City to hear the president's news conference about the new policy.
"Right now, this is a relief — Band-Aid," Huerta said. "There is still a lot to fight for."
The Associated Press contributed to this report


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The Foundation would like to take this opportunity to wish all supporters and donors a very Happy New Year and may you have a year of good health and prosperity, as you continue to make life meaningful for the less fortunate.
As a result of your generous donations, we have been able to directly help hundreds who have been affected by the great flood that occured in Thailand.
Because of your compassion, the despondents were given life-paks which included meals to stave their hunger, dried foodstuff for when no one could reach them and when there is no electricity to cook their food, portable and hygenic toilets to prevent the spread of diseases, medicines for fungal infections that are rampant when the body is in contact with water all the time, milk powder and pampers for the babies, and most important of all, clean drinking water, when even the public utilites were infiltrated with the flood waters that flowed through heavy industrial parks and sewerage.
When the Kasetsart University in Nakhon Prathom set up the Evacuation Centre (for people as well as animals) there, the Foundation donated shampoo to the centre, provided the children evacuees with activities, and our team of volunteers even bathed the distressed dogs of flood victims as well! In addition, blankets were donated in time for the cold weather in the evacuation centre. Volunteer also helped with physical therapy too!
At the same time, the disaster had also affected the rice fields in the North-east province of Saelaphum, and the Foundation was able to help with the rehabilitative efforts there.
Meanwhile, youth volunteers learnt how to make biodegradeable detergents, which were then given to the flood victims when they had to clean up the mess left by the flood.
Due to the floodwaters that had flowed from the north down to the lower central plains near Bangkok, it had left the distric of Chalongkrung like an island, surrounded by water, and the community there were unable to leave their homes because the water level was too high for cars or trucks to drive through. The Foundation responded by bringing life-paks to the children and their families, as soon as the flood receded, to help lighten the burden on the families, as they were mostly labourers receiving daily wages.
Post-flood Relief work also included giving out Christmas presents to help cheer badly affected flood victims who lived by the river banks in Ayutthaya, as well as gathering data from victim for researchers who were looking into the responses of the authorities, speed of news of the coming disaster and source of help.
At the same time post-flood rehabilitative sponsorships were given to 20 victims who were badly affected to help them get back to normalcy in life.
The Foundation again wishes to thank all who had a share in Making the World a Better Place through your Giving!
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
If you donate to this project or have donated to this project, you will get an e-mail when this project posts a report. You can also subscribe for reports via e-mail without donating or by subscribing to this project's RSS feed.
Volunteer to the Foundation for Life


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GriffinQuest is Westminster College's four year leadership program. With a cohort of 10-12 students, each semester will offer a wide variety of experiences that will broaden your leadership abilities.
The program focuses on specific areas of leadership. As a member of GriffinQuest, you will develop your own leadership goals, participate in service activities, and learn more about social justice and diversity.
As a group, GriffinQuest students will learn more about themselves, the community, and the world. In your first few semesters, your focus will be on service and social justice. In your final semesters, you will lead your own group of cohorts.
Thank you for applying to be a team member in the GriffinQuest program. Please read below for further information about GriffinQuest.
GriffinQuest Application Timeline:


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Top-ranked recipe named "To Corn Beef"
Homemade corned beef is not bright pink, but more the color of regular brisket. This is delicious and flavorful--it's fun to make your own corned beef, but you need to start a few days in advance!
Mix together 2 qt cold water and one cup salt. This is your brine. Add the ingredients above to your brine. Place a 3-pound brisket in the brine and cover with an inverted plate to hold it under the brine. Allow beef to stay in the brine for 48 hours (I prefer 4 days) in the refrigerator.
|My private notes
Get the free BigOven app on your phone.
Quickly find any recipe anywhere!
bkprice13 7 years ago[I posted this recipe.]


text:
Grundy Hall 226
1501 East Orange Rd
PO Box 8015
Waterloo, IA 50704-8015
319-296-2329 x1127
319-296-4400 (fax)
All office hours will be announced weekly on ANGEL
I have been teaching college writing since 1999 and have been at Hawkeye Community College since 2005. In addition to teaching, I have also written two series of children's books on character education and manners.
This is the Faculty Directory page of the Hawkeye Community College faculty member named at the top of the page.
Faculty Directory pages are those of the authors and do not in any way constitute official Hawkeye Community College content.
Authors of these pages are responsible for obeying all relevant laws and College policies.
Views expressed on these pages and any pages linked to are strictly those of the page authors.
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The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
all the expressive, creative, and inspirational personalities of our community!
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Let the world know it's time for a little less conversation and a little more fashion with this adorable black dress. Covered from top to bottom in white polka dots and featuring red ric rac trim at the bust and skirt, knotted red edging along the neckline and hem, and a tuft of red netting peeking out at the bottom, this darling frock is sure to get your heart singing. The tied halter top, smocked back, and swingy flared skirt on this figure-friendly number will ensure that you're always on your sweetheart's mind. Pair it with sultry peep toes, a patent purse, and a blooming hair clip for a look that will have everyone thanking you very much for such rocking style.
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Iran will give swift response to any Israeli aggression: Vahidi
Thu Apr 18, 2013 10:4AM
"The constant threats by the Zionist regime (Israel) against Iran are so worthless and they cannot do anything against our nation because they know that any measure will lead them to full annihilation," the Iranian minister pointed out."We don't think that the Zionist regime will take such an unwise action to commit suicide," Vahidi added. In his message on the occasion of Nowruz (Persian New Year) on March 21, Ayatollah Khamenei said Iran would raze Tel Aviv to the ground if Israel carried out a military strike against the Islamic Republic. "Israel's leaders sometimes threaten Iran, but they know that if they do a damn thing, the Islamic Republic will raze Tel Aviv and [the occupied city of] Haifa to the ground," the Leader stated. Vahidi made the remarks after Israel's Chief of Staff Lt. Gen Benny Gantz repeated the regime's warmongering rhetoric against Iran on Tuesday. "We have our plans and forecasts... If the time comes we'll decide" on whether to take military action against Iran, Gantz said. Similar remarks were made by other Israeli officials, including Prime Minister Benjamin Netanyahu and Minister for Military Affairs Moshe Ya'alon. Meanwhile, Netanyahu said that US-engineered sanctions against Iran over its nuclear energy program might not be enough. The US, Israel and some of their allies have repeatedly accused Iran of pursuing non-civilian objectives in its nuclear energy program with the Israeli regime repeatedly threatening to attack Iran's nuclear facilities based on the unfounded allegation. Iran argues that as a committed signatory to the Non-Proliferation Treaty (NPT) and a member of the International Atomic Energy Agency (IAEA), it has every right to use nuclear technology for peaceful purposes. Unlike Iran, Israel, which is widely believed to possess between 200 to 400 nuclear warheads, is a non-signatory to the NPT and continues to defy international calls to join the treaty. SF/HJL/MA


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There are just eight more days to vote in the Best of Denver 2015 Readers' Poll, which includes more than eighty Food & Drink categories, all of which will appear in the final issue on March 26 — with Westword picks along with t...
Reader: Everyone Likes Nostalgia and Kitsch, But the Food at These Old-Timers Sucks
1 year ago by Patricia Calhoun
This summer saw a record number of eateries opening in metro Denver -- but many restaurants also celebrated big anniversaries, including New York Deli News (25th anniversary), Briarwood Inn (35th anniversary) and Wazee Supper Club (...
Is Blue Parrot the oldest family-owned restaurant in metro Denver?
2 years ago by Patricia Calhoun
Chipotle Mexican Grill may have marked the twentieth birthday of its original location this past weekend -- but many restaurants in Denver are much, much older. And while they may not have inspired outposts around the world, some of...
Best Of Awards
More Italian Restaurants in Northwest Denver
An old-time neighborhood Italian joint serving good spaghetti and meatballs, manicotti and pizza ...Italian
Tom and Marna Sumners have doubled the fun with two locations of Trattoria Stella, their hip neig...Italian
The original Parisi Italian Market & Deli opened in 1998, in what's now the home of Cafe Brazil, ...Bakery
More Italian Restaurants in Denver
There's a horseshoe-shaped bar in the middle of the restaurant and bowling trophies all around, b...Italian
The Cherry Tomato is a comfortable place with cracked-tile floors and rough brick walls, a bar cr...Italian
Anthony's is a homegrown pizza empire, and it got its start in this space on California Street th...Italian
As Barolo Grill prepared to enter its third decade, owner Blair Taylor made some changes at his P...Italian
Carmine's on Penn has held down its corner of Pennsylvania and Bayaud since 1994. When the restau...Italian
Cucina Colore has had an enviable run. As other restaurants in Cherry Creek North have come and g...Italian


text:
Softie2k • Comments
Page 1 of 11
Everybody's Gone to the Rapture out in August
Bioshock pun somewhere? Reply 0
The very first screenshots of World of Warcraft
Blizzard announces Timewalking feature for World of Warcraft
God we wiped so much on HoL back in the day!
Don't like many of these instances though :( Reply +1
What made Super Mario 64 so special?
You cannot overstate the quality of Super Mario 64 - for me this is the pinnacle of gaming and won't be bettered. Reply +3
Looks like Square Enix is revealing the new Deus Ex
Bosses weren't that bad. I would create a larger, more open world though, with more secrets. Reply +5
First screenshots of Dragon Age: Inquisition single-player DLC
@Plankton1975 First class is higher than business class :P Reply +1
3D Classics Streets of Rage 2 headed to 3DS eShop
My God, that soundtrack was amazing. Still is actually. Reply +3
Law & Order airs episode dedicated to harassment of women in gaming
Mr girlfriend who is an academic in games and her colleagues have been harassed on university mailing lists by so called Gamergater supports/members.
They're total idiots who have nothing to contribute - and certainly not ethics of any standard. Reply +12
Battlefield Hardline PC requirements confirmed
I've been using Windows 10 since October, for techies there's some good stuff to play with. Reply +2
Grim Fandango Remastered review
Puzzles were too difficult; the game however is too good! Reply +1
Did you know Gaming? runs through the Sega Dreamcast
Chuchu rocket! Reply +4
When the new becomes old - why 2015 should be a stellar year
Why do the voices in the new Rainbow Six game sound like teenage boyband? Reply +15
Bloodborne's grisly Chalice Dungeon grotesquerie
I don't understand these conspiracy nut-job kids that think a business would be in favour of a particular brand for absolutely no reason other than "Xbone sUx!" Reply +5
Batman: Arkham Knight trailer swoops into Ace Chemicals
Wow. Reply +32
Learning to raid: in praise of WOW's finest dungeon
Will Xbox One succeed in China?
These Asian games shops are full of colour and have a massive range of products, stuff like Battlefield and Call of Duty look exceedingly dull sat next to that stuff. Reply +1
Final Fantasy 14: A Realm Reborn hit by DDOS attack
DDOS isn't uncommon in any data center. It may not be a legitimate attack neither - just that the hosting companies that they use report on DDOS for that month.
They may use that data to justify outages that they've caused themselves. Reply -1
Ion Storm's lost Deus Ex Sequels
I think the third game was pretty good, although it stuck to the original DE's formula it made all the same mistakes.
I don't even acknowledge the second existed. Reply +6
Blizzard confirms World of Warcraft DDOS attacks
This doesn't necessarily mean that people were trying to hack it.
Datacenters get DDOS reports every month and are constantly being hit by traffic they class as 'DDOS'. Reply +2
Blizzard reveals Overwatch, a team-based competitive first-person shooter
Never played Team Fortress (except for the original a little), so this looks great to me! Reply +1
Eternal Darkness dev Denis Dyack back with ambitious new studio
The American dream. Reply +2
The Longest Journey remastered is coming to iOS "very soon"
OMG. That is all... Reply 0
Twitch cracks down on "sexually suggestive clothing"
"lingerie, swimsuits, pasties, or undergarments"
It won't be before long that they ban pies too... Reply +133
There's another fan attempt to remake Resident Evil 2
One of the best games ever made, bar none.
Superior to Resi 1 by a long way imo. Reply +10
Jade's Empire
@RobertPaulson No, you're wrong. You say a lot of comes across as 'man-hating' and that's not right, that's a straw man argument.
Take Eurogamer as a perfect example - almost no 'man-hating feminists' and yet many anti-feminists accuse us of such. Reply +1
@masseffectman You're absolutely 100% wrong. Reply 0
@masseffectman It's obvious you don't understand feminism, and that's why you're confused and frustrated. Reply +2
The problem with video game guns
@Common_Sense GoldenEye had great guns! Reply +2
Dreamfall Chapters: Book One review
@Cosbuster I'm still playing it too! I found the original game case the other day and realised I've bought three copies altogether! Reply +1
Anita Sarkeesian cancels university speech following school shooting threat
@mattshark It seems there are a lot of people who have absolutely no understanding of feminism or even what the word means. Reply +2
@Kendrene You'd better learn the definition of feminism before you engage in a debate where you clearly state you're not one.
Feminism: the belief that women should be allowed the same rights, power, and opportunities as men and be treated in the same way, or the set of activities intended to achieve this state
http://dictionary.cambridge.org/dictionary/british/feminism Reply +6
@Deede No, this is wrong. I wasn't a feminist and was just as annoyed at 'men-haters' as much as anyone on this thread. I then had my mind changed by a group of doctors at Leeds University - whom I now go to the pub with regularly. I fought initially, defending my turf, but I soon had to concede after I calmed down and recognise that there is a massive imbalance in the way we're represented in culture and that it has to change.
In fact the change isn't just moral, it's more interesting to boot. I can't wait to see more female developers and what they bring to the development table I can't wait to see more interesting female characters in games, more interesting stories and better portrayals of relationships.
It's all exciting, and it takes nothing aware from men, it's a win-win situation in my view.
Recognising this however, especially if you're defending the opposing view ferociously enough, is very tough and requires a big 'man' to come down and say "sorry guys, I was wrong".
I'm saying this now, as I too have been wrong and had to dig deep - "I was wrong and to all the people I was a twat with, you know I'm sorry". Reply +3
@TheLastPixel Feminists want more? What more do they want? Please provide us with the details. Reply +3
@Yossarian Your replies are excellent. I just wish I had written them!
Keep going! Reply 0
@joeymoto108 Did you read what I wrote? You've said it's a flimsy argument and I wrote that this isn't an argument any more. Academics have looked at the evidence and there are now hundreds of articles in academic journals (they're not necessarily accessibly to the public, you'd have to go to a library to find one you liked and even order it in the library) about sexism and gender issues in games. The subject matter has closed, it's just those people who haven't read studies that disagree. Reply 0
@the_rydster I'll amend my original post in that case as I understand what you're getting at.
"It's already concluded by the academic community(impartial people who study philosophy their entire lives as a job); games on the whole are sexist."
They don't claim it would be beneficial to alter it, but they do claim that they're sexist. Thanks. Reply 0
It's already concluded by the academic community(impartial people who study philosophy their entire lives as a job); games on the whole are sexist and it would be immensely beneficial to alter that.
If you disagree with that, it's either because A) you've given it no thought or B) you feel entitled as someone who plays a lot of games to maintain a status quo to avoid your hobby being changed in any way based on an irrational fear you have ,that levels of enjoyment might diminish or your access to your hobby restricted should we let any one who might be different than 'us' have a say in 'our' industry. Reply +2
Firaxis opens its doors at the first Firaxicon
Really worried about Beyond Earth - I've been waiting for this for a decade and so far it just doesn't seem to have hit the spot...Got everything crossed though. Reply +3
Final Fantasy 15 demo coming in March - report
It'll be hyper-turd. There hasn't been a FF that I've really enjoyed since FFIX Reply -2
Planetary Annihilation review
I still play Total Annihilation; I'm still trying to finish the Kroggoth encounter :$ Reply +5
The Sims 4 review
@Ep1cN3ss1e Ok let's compare it.
No create a style (CAST) - NOT possible in future expansions (x)
No modifications to world/public spaces � The park in the demo is a mix of a community lot and public space (x1) (x2)
No �normal� careers - Law enforcement, Medical, Business, etc. were removed (x)
No open world � You must incur a loading screen between each active lot; each neighborhood has 1-5 lots total (x1) (x2)
No pools (x)
No terrain tools other than paint; everything is perfectly flat (x)
No story progression � Sims in the neighborhood age, but do not have children, get jobs, move, get married�etc. without player intervention (x)
No toddlers (x)
No way to create/place new lots � And you only have 2 empty ones at the start of the game!
No Mac version of the game at release
All buildings on a lot must have the same foundation. No mixing for sheds, garages, etc. (x)
Babies are mere objects � All interactions are through basinet. There are no baby objects. Babies can only be lifted directly above basinet. (x)
Backgrounds are illusions � The buildings in the background are not playable in the game. (x)
Completely FLAT lots � The entire build-able world is completely flat (x)
Fewer floors/levels, limited to three (x1) (x2)
SIGNIFICANTLY smaller �worlds� of Reply +16
I never ever criticise reviewers to be honest, I think Eurogamer is great on the whole.
There's barely any mention of all the content that's missing and how that really affects the game. This is a big series and it's a major draw back to remove a great deal of the content that its predecessors had.
Could you imagine the next Elder Scrolls game going back to linear levels? That's the same thing.
The score might be a fair assessment, but the tone of the review just doesn't sit well with me after playing the game. Reply +15
One paragraph on what's missing on the game compared to the others? Is that a joke? Reply +1
Editor's blog: I'm leaving Eurogamer later this year
8/10 would read. Reply 0
The Sims 4 pirated copies include censoring "glitch"
Same limited engine - Glass box. Oh the irony, you can see everything you want to interact with, outside of the glass box. Reply +3
Editor's blog: A brief note about "GamerGate"
@Commandprawn Are you serious? Reply +11
100% behind this. We need more people to vocal about it though. Reply +4
Why we need more developers like Zoe Quinn
@Avaloner I so badly want you to open your mind and see how you're missing the bigger picture. In fact I don't necessary think you are any more, I actually think you're probably more open to what she's had to say than any time before it even though you're defending your position with a lot of enthusiasm.
For me, I see girls and women being victims of culture; depictions of frail or objectified women with few or sometimes no role models, certainly in the way men have.
I'm a regular guy who loves games, AAA with all the stuff that goes with it, but I also want it to change desperately, so that a new generation of women don't see themselves the same way and we'll get more female games developers with new and interesting ideas.
I know that you've put a lot of effort into your arguments, but I do hope that some day you'll see some of the sense in what we've had to say. I don't think we're necessary totally correct with everything we've written, but I hope one day you'll see the sort of change we're getting at and agree/partly agree with it. :) Reply -2


text:
Resolution: standard / high
Figure 3.
Developmental expression of β- and γ-synuclein in different mouse strains.A. 15% SDS-PAGE was performed on brain homogenate from the 129/Ola, ICR, and the BL6JHUK strain at time points P0, P8, P15, and adult (20 μg protein per lane). The Western blot membrane was probed with polyclonal anti β-synuclein IgG, detecting the 19 kDa protein. The lower part shows the anti α-tubulin control. B. Northern blot of brain polyA+-RNA (500 ng per lane) from 129/Ola, ICR, and BL6JHUK mice at different developmental stages (P0, P8, P15, and adult). Probing with a 3'UTR γ-synuclein probe detects a transcript of approximately 0.8 kB. RNA samples were pooled from 4 animals (at P0), or from 2 animals (at P8 and P15) from one litter (same membrane as in Fig. 1B, actin control identical to Fig. 1B).
Specht and Schoepfer BMC Neuroscience 2001 2:11 doi:10.1186/1471-2202-2-11


text:
who cares if you developed cancer. I have experienced exactly 1 glitch in my entire time playing.why people expect instant sympathy when they develop a cellular anomaly is beyond me. I feel more sorry for people who get struck by lightning. at least their chances of death at that moment were infinitesimally small, and therefore renders it a tragic surprise. with cancer and terminal diseases/conditions you are given plenty of time to get your affairs in order, say your goodbyes and hell, climb mount everest or something. and you just sat and waited for a game.
I'm sorry you have cancer, but games have glitches. It's almost natural. The only company I've seen without them in the last few years is Square Enix. They dont make the game unplayable, though they are numerous.Oh and treatment is actually getting much better under many organizations. Choose the right people, and life may not be so short.
You are not allowed to request a sticky.


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LH and FSH Blood Tests - when to take(3 Posts)
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Another "chocolate truffles" recipe ranks higher.
1.stir chocolate and cream on low heat until melted together.
2.put into heat proof pan/bowl and put in fridge for 2 to 3 hours.
3.roll into balls and coat with cocoa or chocolate shavings. :)
|My private notes
Get the free BigOven app on your phone.
Quickly find any recipe anywhere!
domonique 6 years agothat was delcious, so was the texture, sure child treat.
domonique 6 years agochocolate is ready when it can be pushed and not make a whole but a dint. [I posted this recipe.]


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Livex Lighting 2140-16 Verde Patina 1 Light 150W Post Light with Medium Bulb Base and Iridescent Tiffany Glass from Montclair Mission Series
Item #:
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1 Light 150W Post Light with Medium Bulb Base and Iridescent Tiffany Glass from Montclair Mission Series
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Rated 3 out of 5 by SHSB from The lamp is beautiful and look fabulous on the pole. The top was not welded properly on one of the four corners. I will have to return it which I hope will not be an issue.
Date published: 2011-08-14
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Mikhail Shlyapnikov, a farmer in the isolated Russian village of Kolionovo, thought he had found a way to make economic transactions in the cash-strapped settlement easier: He began printing kolions, exchange notes to be used by villagers instead of cash.
One kolion equaled 10 kilograms of potatoes. In a village where residents would only get hard cash several times a year — during harvest and sowing — kolions would make the exchange of goods easier. Workers could plow a piece of land for a few kolions and then exchange them for vegetables, fruit or fish.
But in his attempt to establish a self-sustaining community with its own system of cashless transactions, Shlyapnikov attracted the attention of the government. Continue reading Anarchist Russian Farmer to Defend His Village Currency in Court


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Current Highlights on Broadway
Find a show or venue
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Other Concert Venues in New York
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Oct 14, 2015
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Nov 7, 2015
The Weeknd
Nov 11, 2015
Trans-siberian Orchestra: The Ghosts Of Christmas Eve
Dec 12, 2015
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Feb 17, 2016
October 14, 2015
After playing a sell-out concert in December 2013 of his legendary 1976 album, Stevie Wonder is now taking it on the road as a celebration of this iconic piece of musical history. Songs in the Key of Life is an ambitious and infectious masterpiece, including some of Wonder's most popular hits such as Sir Duke and Isn't she Lovely, it is considered his landmark record and still regularly crops up in best album lists worldwide.
November 7, 2015
One of the greatest heavy metal bands of all time, Judas Priest released their seventeenth studio album last year with Redeemer of Souls. It was yet another collection of rock solid, pile-driving riffage from the British group, featuring the songs Battle Cry and the title track. Joining them on this 2015 North American tour is Mastodon, the Atlanta metal band who at the genre's forefront in the 21st Century.
November 11, 2015
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December 12, 2015
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text:
|Accession Numbers: EG10348 (MetaCyc), b2800, ECK2795
Synonyms: fucC, prd
Species: Escherichia coli K-12 substr. MG1655
Subunit composition of L-fuculose-phosphate aldolase = [FucA]4
FucA can function as both an L-fuculose-phosphate aldolase and a D-ribulose-phosphate aldolase, the third enzyme of the L-fucose and D-arabinose degradation pathways, respectively. However, production of FucA is only induced by L-fucose [LeBlanc71a, LeBlanc71].
The substrate specificity of the enzyme was tested with a partially purified preparation from an unnamed E. coli strain [Ozaki90].
Crystal structures of the enzyme and a number of point mutants have been solved. The combination of structural data and enzymatic activity of mutants allowed modelling and refinement of the catalytic mechanism of the enzyme. [Dreyer93, Dreyer96, Dreyer96a, Joerger00, Joerger00a]
The enantiomeric selectivity of the enzyme has been studied [Joerger00].
A fucAO deletion mutant colonizes the mouse intestine and maintains its population at a lower level than wild type; the accumulation of fuculose-1-phosphate appears to enable the mutant to switch to utilization of ribose for growth [Autieri07].
Locations: cytosol
|Map Position: [2,931,063 <- 2,931,710]
Molecular Weight of Polypeptide: 23.775 kD (from nucleotide sequence)
pI: 6.51
Unification Links: ASAP:ABE-0009179 , CGSC:17701 , DIP:DIP-9710N , EchoBASE:EB0344 , EcoGene:EG10348 , EcoliWiki:b2800 , ModBase:P0AB87 , OU-Microarray:b2800 , PortEco:fucA , PR:PRO_000022727 , Protein Model Portal:P0AB87 , RefSeq:NP_417280 , RegulonDB:EG10348 , SMR:P0AB87 , String:511145.b2800 , UniProt:P0AB87
Relationship Links: InterPro:IN-FAMILY:IPR001303 , InterPro:IN-FAMILY:IPR004782 , PDB:Structure:1DZU , PDB:Structure:1DZV , PDB:Structure:1DZW , PDB:Structure:1DZX , PDB:Structure:1DZY , PDB:Structure:1DZZ , PDB:Structure:1E46 , PDB:Structure:1E47 , PDB:Structure:1E48 , PDB:Structure:1E49 , PDB:Structure:1E4A , PDB:Structure:1E4B , PDB:Structure:1E4C , PDB:Structure:1FUA , PDB:Structure:2FUA , PDB:Structure:3FUA , PDB:Structure:4FUA , Pfam:IN-FAMILY:PF00596 , Smart:IN-FAMILY:SM01007
GO Terms:
|Biological Process:
|GO:0019571 - D-arabinose catabolic process
GO:0042355 - L-fucose catabolic process [GOA06, LeBlanc71]
GO:0005975 - carbohydrate metabolic process [UniProtGOA11a]
GO:0006004 - fucose metabolic process [UniProtGOA11a, GOA01a]
GO:0019317 - fucose catabolic process [UniProtGOA12]
|Molecular Function:
|GO:0008738 - L-fuculose-phosphate aldolase activity
[GOA06, GOA01, GOA01a, Joerger00]
GO:0016832 - aldehyde-lyase activity [LeBlanc71]
GO:0008270 - zinc ion binding [GOA06, GOA01a]
GO:0016829 - lyase activity [UniProtGOA11a]
GO:0046872 - metal ion binding [UniProtGOA11a]
|Cellular Component:
|GO:0005829 - cytosol [DiazMejia09]
|MultiFun Terms:
|metabolism → carbon utilization → carbon compounds
Created in EcoCyc 19-Oct-2007 by Keseler I , SRI International
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
Enzymatic reaction of: L-fuculose-phosphate aldolase
Synonyms: L-fuculose-1-phosphate aldolase, L-fuculose-1-phosphate lactaldehyde-lyase
EC Number: 22.214.171.124
L-fuculose 1-phosphate <=> (S)-lactaldehyde + glycerone phosphate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
This reaction is reversible.
Alternative Substrates for (S)-lactaldehyde [Ghalambor62 ]: L-glyceraldehyde [Ghalambor62 ] , glycolaldehyde [Ghalambor62 ]
In Pathways: superpathway of fucose and rhamnose degradation , fucose degradation
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
This enzyme was first purified from E. coli strain O-111 B4 [Ghalambor62].
The Ki for phosphoglycolohydroxamate is 3.1 µM [Fessner96].
Cofactors or Prosthetic Groups: Zn2+ [GarciaJunceda95a]
Inhibitors (Competitive): phosphoglycolohydroxamate [Dreyer96a, Fessner96]
Kinetic Parameters:
Enzymatic reaction of: D-ribulose-phosphate aldolase (L-fuculose-phosphate aldolase)
D-ribulose 1-phosphate <=> glycolaldehyde + glycerone phosphate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
This reaction is reversible.
In Pathways: superpathway of pentose and pentitol degradation , D-arabinose degradation I
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
The relative rate of the enzymatic activity with glycolaldehyde as the substrate is 59% of that with lactaldehyde [Ozaki90].
Cofactors or Prosthetic Groups: Zn2+ [GarciaJunceda95a]
Inhibitors (Unknown Mechanism): phosphoglycolohydroxamate [Dreyer96a, Fessner96]
|Feature Class
10/20/97 Gene b2800 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG10348; confirmed by SwissProt match.
Autieri07: Autieri SM, Lins JJ, Leatham MP, Laux DC, Conway T, Cohen PS (2007). "L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium." Infect Immun 75(11);5465-75. PMID: 17709419
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Dreyer93: Dreyer MK, Schulz GE (1993). "The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli." J Mol Biol 231(3);549-53. PMID: 8515438
Dreyer96: Dreyer MK, Schulz GE (1996). "Refined high-resolution structure of the metal-ion dependent L-fuculose-1-phosphate aldolase (class II) from Escherichia coli." Acta Crystallogr D Biol Crystallogr 52(Pt 6);1082-91. PMID: 15299567
Dreyer96a: Dreyer MK, Schulz GE (1996). "Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure." J Mol Biol 259(3);458-66. PMID: 8676381
Fessner96: Fessner W-D, Schneider A, Held H, Sinerius G, Walter C, Hixon M, Schloss JV (1996). "The mechanism of Class II, metal-dependent aldolases." Angew Chem Int Ed Engl 35:2219-2221.
GarciaJunceda95a: Garcia-Junceda E, Shen GJ, Sugai T, Wong CH (1995). "A new strategy for the cloning, overexpression and one step purification of three DHAP-dependent aldolases: rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase." Bioorg Med Chem 3(7);945-53. PMID: 7582972
Ghalambor62: Ghalambor MH, Heath EC (1962). "The metabolism of L-fucose. II. The enzymatic cleavage of L-fuculose 1-phosphate." J Biol Chem. Aug;237:2427-33. PMID: 13898172
GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.
GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."
GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."
Joerger00: Joerger AC, Gosse C, Fessner WD, Schulz GE (2000). "Catalytic action of fuculose 1-phosphate aldolase (class II) as derived from structure-directed mutagenesis." Biochemistry 39(20);6033-41. PMID: 10821675
Joerger00a: Joerger AC, Mueller-Dieckmann C, Schulz GE (2000). "Structures of l-fuculose-1-phosphate aldolase mutants outlining motions during catalysis." J Mol Biol 303(4);531-43. PMID: 11054289
LeBlanc71: LeBlanc DJ, Mortlock RP (1971). "Metabolism of D-arabinose: a new pathway in Escherichia coli." J Bacteriol 106(1);90-6. PMID: 4928018
LeBlanc71a: LeBlanc DJ, Mortlock RP (1971). "Metabolism of D-arabinose: origin of a D-ribulokinase activity in Escherichia coli." J Bacteriol 106(1);82-9. PMID: 4323967
Ozaki90: Ozaki A, Toone EJ, von der Osten CH, Sinskey AJ, Whitesides GM (1990). "Overproduction and substrate specificity of a bacterial fuculose-1-phosphate aldolase: A new enzymatic catalyst for stereocontrolled aldol condensation." J Am Chem Soc 112:4970-4971.
UniProt15: UniProt Consortium (2015). "UniProt version 2015-01 released on 2015-01-16 00:00:00." Database.
UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."
UniProtGOA12: UniProt-GOA (2012). "Gene Ontology annotation based on UniPathway vocabulary mapping."
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Housing first priorityUPDATED 8:55 PM HST Mar 10, 2014
Getting the chronically homeless off city streets will take money, and lots of it. Mayor Kirk Caldwell's administration defended spending more than $20 million dollars on the controversial Housing First program. KITV4's Andrew Pereira attended today's budget hearing and has the latest developments.Video Transcript
money, and lots of it! Today, Mayor Kirk Caldwell's administration defended spending more than $20 million dollars on the controversial Housing First program. But even if the City Council approves, getting communities to accept Housing First could be an even BIGGER challenge. KITV4's Andrew Pereira attended today's budget hearing and has the latest developments. 32-37 59-107 Housing First does exactly what it says... Chronically homeless are given a place of their own, BEFORE tackling issues of substance abuse or mental health. The federal government says that's how the city should spend its grant money from Uncle Sam. PAMELA WITTY-OAKLAND: "THEY REALLY WANT US TO FOCUS ON THAT PERMANENT COMPONENT." To accomplish that goal, Mayor Kirk Caldwell's administration is requesting $18.9 million for the upcoming capital improvements budget and another $3 million in operating funds. PAMELA WITTY-OAKLAND: "WE COULD PROBABLY ACQUIRE, OR REHAB AND ACQUIRE A UNIT FOR ABOUT $100,000 PER UNIT. SO, WITH $18.9 MILLION WE COULD GET TO 189 OR 200 UNITS." To qualify for Housing First, a person or head of household must earn 50 percent or below of a geographical area's median income. The city is examining whether to launch Housing First through a voucher program that would place the chronically homeless in individual units throughout Oahu, or go after a fixed location where homelessness is a major problem. Either way, it may be a hard sell. JUN YANG: "THERE'S GOING TO BE SOME COMMUNITY EDUCATION ON WHAT HOUSING FIRST REALLY MEANS. MANY PEOPLE THINK OF HOUSING AS SOMETHING LIKE A SHELTER. IT IS NOT LIKE A SHELTER. WE HAVE CASE MANAGEMENT THAT WILL BE WRAPPED IN WITH HELPING THE PERSON TO BECOME INDEPENDENT." If the city goes after a fixed location for Housing First, the city's River Street property is NOT an option because of backlash from the Chinatown community. The top priority is placing them SOMEWHERE.. PAMELA WITTY-OAKLAND: "WE'VE GOT OVER 4,000 FOLKS WHO ARE CONSIDERED HOMELESS, EITHER LIVING IN SHELTERS OR UNSHELTERED. SO, WE HAVE A NEED WE NEED TO ADDRESS." Director Witty-Oakland is considering using some units from the city's affordable housing portfolio for the Housing First program. She says that would ONLY happen if residents currently at those complexes agree.
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Researchers at MIT and the University of Vienna have created an imaging system that reveals neural activity throughout the brains of living animals. This technique, the first that can generate 3-D movies of entire brains at the millisecond timescale, could help scientists discover how neuronal networks process sensory information and generate behavior.
The team used the new system to simultaneously image the activity of every neuron in the worm Caenorhabditis elegans, as well as the entire brain of a zebrafish larva, offering a more complete picture of nervous system activity than has been previously possible.
"Looking at the activity of just one neuron in the brain doesn't tell you how that information is being computed; for that, you need to know what upstream neurons are doing. And to understand what the activity of a given neuron means, you have to be able to see what downstream neurons are doing," says Ed Boyden, an associate professor of biological engineering and brain and cognitive sciences at MIT and one of the leaders of the research team. "In short, if you want to understand how information is being integrated from sensation all the way to action, you have to see the entire brain."
The new approach, described May 18 in Nature Methods, could also help neuroscientists learn more about the biological basis of brain disorders. "We don't really know, for any brain disorder, the exact set of cells involved," Boyden says. "The ability to survey activity throughout a nervous system may help pinpoint the cells or networks that are involved with a brain disorder, leading to new ideas for therapies."
Boyden's team developed the brain-mapping method with researchers in the lab of Alipasha Vaziri of the University of Vienna and the Research Institute of Molecular Pathology in Vienna. The paper's lead authors are Young-Gyu Yoon, a graduate student at MIT, and Robert Prevedel, a postdoc at the University of Vienna.<
|Contact: Sarah McDonnell
Massachusetts Institute of Technology


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Little League World Series
A player from the Japan Little League team looks at the front page of... Fotografia de notíciasAssunto,Basebol,Basebol Juvenil,Bestof,Brincar,Desporto,EUA,Equipa Desportiva,Equipa de basebol,Horizontal,Little League,Olhar,Pensilvânia,Pessoas,South Williamsport,TopixPhotographer Drew HallowellCollection: Getty Images Sport 2010 Getty ImagesSOUTH WILLAMSPORT, PA - AUGUST 29: A player from the Japan Little League team looks at the front page of the Williamsport Sun-Gazette after the game against the United States on August 29, 2010 in South Willamsport, Pennsylvania. Japan went on to win the Little League World Series Championship 4-1. (Photo by Drew Hallowell/Getty Images)


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The study, which applied cutting-edge analyses designed by the JCU researchers to and data from the Australian Institute of Marine Science's 15-years of surveys across the Great Barrier Reef, found that protection was provided by having a diversity of fish that perform a similar function chomping down seaweed because different fishes respond differently to different pressures.
"There are three main groups of herbivorous fishes: territorial grazers that bite at the algae and are site-attached and actively defend a small patch of reef, roving grazers that feed in the same way but move around the reefs, and scrapers who range widely and feed by biting the algae back to the limestone surface of the reef, making clear patches where corals can establish. All are critically important," says study co-author Dr Hugh Sweatman, a Senior Research Scientist at the Australian Institute of Marine Science.
"These groups all play a similar role in keeping weeds in check, but each type responds differently to environmental fluctuations."
"In this research, we measured how strong the 'portfolio effect' was in different reef locations. We found that high biodiversity makes seaweed control twice as stable as it would be if we relied on one super-abundant species, like the sea urchin in the Caribbean," says Prof. Connolly.
"Biodiversity reduces the risk that environmental fluctuations will push overall herbivory below the threshold that might trigger a regime shift towards seaweed-dominated reefs."
The finding highlights the importance of maintaining biodiversity in the coral ecosystem, the researchers say.
"The more diversity you have, the lower the risk that all the fish that play a particular role on the reef like controlling seaweeds will crash at the same time. This is greatly
|Contact: Sean Connolly
ARC Centre of Excellence in Coral Reef Studies