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Protein kinases are involved in relevant physiological functions and a broad number of mutations in this superfamily have been reported in the literature to affect protein function and stability. Unfortunately, the exploration of the consequences on the phenotypes of each individual mutation remains a considerable challenge.
The wKinMut web-server offers direct prediction of the potential pathogenicity of the mutations from a number of methods, including our recently developed prediction method based on the combination of information from a range of diverse sources, including physicochemical properties and functional annotations from FireDB and Swissprot and kinase-specific characteristics such as the membership to specific kinase groups, the annotation with disease-associated GO terms or the occurrence of the mutation in PFAM domains, and the relevance of the residues in determining kinase subfamily specificity from S3Det. This predictor yields interesting results that compare favourably with other methods in the field when applied to protein kinases.
Together with the predictions, wKinMut offers a number of integrated services for the analysis of mutations. These include: the classification of the kinase, information about associations of the kinase with other proteins extracted from iHop, the mapping of the mutations onto PDB structures, pathogenicity records from a number of databases and the classification of mutations in large-scale cancer studies. Importantly, wKinMut is connected with the SNP2L system that extracts mentions of mutations directly from the literature, and therefore increases the possibilities of finding interesting functional information associated to the studied mutations.
wKinMut facilitates the exploration of the information available about individual mutations by integrating prediction approaches with the automatic extraction of information from the literature (text mining) and several state-of-the-art databases.
wKinMut has been used during the last year for the analysis of the consequences of mutations in the context of a number of cancer genome projects, including the recent analysis of Chronic Lymphocytic Leukemia cases and is publicly available at http://wkinmut.bioinfo.cnio.es webcite.
Current high-throughput resequencing screenings [1-3] represent a powerful set of techniques to discover large numbers of mutations. Of these, only a small fraction are causally implicated in disease onset and therefore, separating the wheat from the chaff is still a major challenge [4]. The interpretation of the overwhelming wealth of data also represents an issue in other fields, such as protein function prediction [5]. For a small subset of the new mutations discovered, experimental information regarding the relationship between the mutation and the underlying biochemical mechanism is known. However, there is no information for the remaining mutations. The intensive requirement of resources makes it unfeasible to experimentally test the association of all these mutations to disease, and to characterize their functional effects. Nevertheless, this problem is very amenable to in silico predictors [4,6,7]. Different approaches are currently available to predict the probability of a newly discovered mutation being implicated in disease. Some methods identify crucial positions in a given protein and derive generalized rules to predict the pathogenicity of mutations. Other methods assume that evolutionarily conserved protein residues are important for protein structure, folding and function, whereby mutations in these residues are considered deleterious [8]. Variations on this principle lead to methods that predict deleterious mutations by evaluating changes in evolutionarily conserved PFAM motifs [9]. A number of systems use protein structures to characterize substitutions that significantly destabilize the folded state. There are also methods that integrate prior knowledge in the form of both sequence and structure-related features from a set of experimentally characterized mutations to train automatic machine-learning systems. These systems can infer the pathogenicity of new mutations based on the cases evaluated. Albeit similar in purpose, very different machine-learning methods can be implemented. Among them, probably the most popular ones are: rule-based systems [10-12], decision trees [13], random forests [14,15], neural networks [16,17], Bayesian methods [18] and SVMs [19-23]. Recently, some meta approaches that combine different methodologies have been implemented. For example, Condel [24] integrates five of the most widely employed computational tools for detecting pathogenic single nucleotide variations. Predictors can also be classified according to their scope. Most of the predictors are generally applicable to amino acid sequences from any protein family, while a few of them include properties that apply only to a given protein family of interest; i.e. protein kinase specific predictors [20,23]. These family-related features bring discriminative information that justifies the development of specialized predictors.
A broad number of mutations in the protein kinase superfamily have been reported in the literature [25] and a subset of them is known to disrupt protein structure and function [26]. For some cases, since human protein kinases are involved in a plethora of physiological functions, this disruption can be causally associated to disease [27]. Still, the majority of protein kinase mutations are tolerated without apparent significant effects [28,29].
In previous publications, we have discussed the preferential distribution of germline pathogenic deviations [30] and driver somatic mutations [31] with respect to regions of functional and structural importance. Here we present, wKinMut, an integrated web-service for the collection of information from multiple sources and for the prediction of the pathogenicity of mutations by combining several prediction approaches. The objective of wKinMut is to provide a one-stop resource for the analysis and interpretation of the consequences of mutations in the protein kinase superfamily.
wKinMut represents the first resource to provide an integrated tool for the analysis and interpretation of the consequences of mutations in the protein kinase superfamily. The main objective of wKinMut is to aid computational biologists and clinicians to prioritize pathogenic mutations and to understand the mechanisms by which some mutations lead to disease, and particularly, to cancer.
The tool presented here, incorporates information retrieval and prediction approaches and displays information from diverse sources. First, it simplifies the collection of information about the mutations, such as the classification, domain architecture, functional annotations and plausible interaction partners of the kinase. Furthermore, kinase mutations are analyzed in their structural context and mentions in dedicated databases, genotyping studies and the literature that suggest an implication in disease are also presented. Second, wKinMut estimates the theoretical pathogenicity of kinase mutations with three different approaches, including our newly developed kinase-specific method, KinMut [23], based on the evaluation of a wide set of sequence-derived features that describe each independent mutation. The affected domain and kinase group, diverse functional annotations, residue physicochemical properties and relevance of the mutated residues in determining subfamily specificity are considered.
wKinMut has been implemented mostly in Ruby. The functionality is implemented as a workflow accessible through a REST interface that can render the results either in JSON format or HTML. The later constitutes the interface described in this document. Some of data resources that support this system, such as gene descriptions or iHOP interactions, are queried remotely through the internet as demanded; but are then cached to improve subsequent accesses. The server incorporates some additional caching schemes to improve performance in the back-end, by persisting the job results, and in the web interface, by caching the HTML.
Web interface
Step 1: submission of mutations for analysis
The input to wKinMut are non-synonymous mutations in the protein kinase superfamily. The input format should encode the Uniprot/Swissprot accession number, the wild type residue, the position and the mutated residue. Non-standard amino acids and truncating mutations will be excluded from the analysis. An example of this format would be a mutation from Glycine to Alanine in position 719 of the human epidermal growth factor receptor, which is encoded as P00533 G719A. In the following sections, we will use this example to guide the reader through the different result views (Figure 1). Multiple mutations can be submitted at a time, either as a plain text file or directly via the applications form, the sample dataset provided as part of wKinMut's documentation can be used as a formatting guide.
Figure 1. Summary of the different result pages in wKinMut: Example of a Gly-719-Ala mutation in the human epidermal growth factor receptor. The figure shows an example of an input to the server (panel a) and the results summary table (panel b). The rest of panels display show the different outputs from the server, including the gene/protein summary tab (panel c), the domain tab (panel d), the structure view (panel e), the pathogenicity assessment (panel f). Information from the databases, the literature and iHop is exemplified in panels g, h and i respectively.
Step 2: interpretation of the consequences of the mutations
The first output the user will get right after submitting the mutations is a summary page with useful information about the requested mutations (Figure 1, panel b). It includes a description of the proteins in Uniprot, the membership to kinase groups in the classification in KinBase [32,33] and the estimation of the pathogenicity of mutations attending to our kinase-specific predictor of pathogenicity, KinMut [23]. The prediction of the pathogenicity will be discussed in detail in a forthcoming section, nevertheless we decided to include this information at this step as a guide to prioritize mutations. It might be interesting to point out here that users interested only in the results from KinMut, can find a link to the predictions in this summary page that can be accessed programmatically. The scope of wKinMut goes beyond providing raw prediction of pathogenicity from KinMut, the web-service's main goal is to aid computational biologists and clinicians to understand and to interpret the consequences of kinase mutations. Hence, information complementary to KinMut predictions, is provided. In the summary table, the 'View' link in the right-most 'Details' column (Figure 1, panel b) will redirect the user to another page containing this complementary information, which includes: the values of the features used for classification, PFAM domains affected by the mutation, protein-protein interaction information extracted from the literature with iHop [34], mentions of the mutations in the literature automatically mined with SNP2L [25,35], and existing records of the mutations in other dedicated databases. This additional information is intended to provide the basic background to help to understand and interpret the consequences of the mutations. Each individual piece of information will be discussed thoroughly in the following sections.
General information about the protein/gene
Information under the 'gene/protein' tab (Figure 1, panel c) focuses on information shared by all mutations in the same kinase. Background information such as the gene name, the formal description in Uniprot and the classification in KinBase [32,33] of the kinase is provided. In addition, the system provides the Gene Ontology terms with which the kinase has been annotated in each of the independent sub-ontologies (namely Molecular Function, Cellular Compartment and Biological Process). This information provides clues to unveil the function of the kinase and it is used by KinMut to calculate the likeness of the protein (and subsequently the mutation) to play a role in disease.
PFAM domains
In a previous publication [23] we demonstrated that mutations occurring in certain domains such as the Tyrosine kinase domain (PKinase Tyr, according to PFAM) are more likely to cause disease. This is coherent with the assumption that the function of some domains is more important than the function of others. In wKinMut, this information is contained in the 'PFAM domains' tab (Figure 1, panel d), which displays the domain (or domains, in some cases) where the mutation is occurring and the alignment used by PFAM as seed to generate the domain family. The alignment is evaluated in terms of sequence conservation. Under the assumption that conserved regions have been preserved by evolution, this information can help the user to identify important regions in the structure of the domain.
Mapping the mutations onto structures
To understand the consequences of mutations might have in protein stability and function it is sometimes useful to study the mutations in their structural contexts. However, mapping mutations from sequences to structures is not always trivial [36]. Under the 'Structures' tab, wKinMut enables the visualization of the mutation mapped to all available structures. (Figure 1, panel e). In addition, the versatility of the Jmol applet implemented in wKinMut allows advanced users to adapt the visualization to their specific needs.
Prediction of the pathogenicity
In wKinMut the theoretical pathogenicity of mutations is assessed by two independent methods, namely SIFT [8] and KinMut [23]. This information is displayed in the 'Pathogenicity' tab (Figure 1, panel f). SIFT [8] predicts whether non-synonymous mutations are prone to affect protein function. This prediction is based on the degree of conservation of the residues in sequence alignments derived from closely related sequences. A threshold value of 0.05 is used to determine that mutations are likely to be pathogenic. KinMut [23] is a kinase-specific predictor of the pathogenicity of mutations. It relies in a machine-learning approach (SVM) to evaluate a number of sequence-derived features that describe kinase mutations from different perspectives, including: a) at the gene level, the membership to a Kinbase group and Gene Ontology terms. b) at the domain level, the occurrence of the mutation inside a PFAM domain, and c) at the residue level, several properties including amino acid type, functional annotations from Swissprot and FireDB [37], specificity-determining positions, etc. SVM scores greater than -0.5 indicate that the mutation is very likely pathogenic. The values of these features are also displayed in this section of the web-service to aid to interpret the predictions. Please, refer to the original publications for information on the individual characteristics, capabilities and validation of each predictor.
Mutations in databases
The wealth of knowledge provided by current research is usually stored in databases. A number of them store information about mutations from diverse perspectives. In wKinMut (Figure 1, panel g) we collect information from four different sources (namely the Uniprot Variant Pages [38], KinMutBase [39], SAAPdb [26] and COSMIC [40]) in an attempt to cover all aspects of protein kinase mutation. The information displayed includes information about the structural consequences of mutations, experiments associating mutations with a certain disease, or the proof that a mutation has been observed in a cancer sample.
Automatic extraction of mutations from the literature
Unfortunately, the databases referred in the previous section do not contain all current knowledge about mutations. Even in the cases where a database record exists, the knowledgebase cannot always store all contextual information. The context is sometimes very important for the correct interpretation of the predictions: experimental conditions, patients' habits and clinical histories, etcetera. wKinMut provides pointers to mentions of the mutations in the literature under the 'Literature' tab (Figure 1, panel h). We extract this information automatically using our in-house text mining approach,SNP2L [25]. In brief, SNP2L is a literature mining pipeline for the automatic extraction and disambiguation of singlepoint mutation mentions from both abstracts as well as full text articles, followed by a sequence validation check to link mutations to their corresponding kinase protein sequences.
Automatic determination of interaction partners
wKinMut integrates Protein-Protein Interactions (PPI) gathered from iHOP in the homonymous tab (Figure 1, panel i). Briefly, iHOP is a powerful text mining system to automatically extract protein protein interactions from PubMed abstracts. To relate the interaction information with its context, the sentences including the interaction mentions are also provided.
wKinMut facilitates the exploration of the information available about individual mutations by integrating prediction approaches with the automatic extraction of information from the literature (text mining) and several currently available databases. wKinMut works as an open accessible web server.
The system offers direct prediction of the potential pathogenicity of the mutations from a number of methods, including our recently developed prediction method based on the combination of information from a range of diverse sources with a machine learning system [23]. The features used by our new prediction system include: general physicochemical properties, annotations of known functional sites from FireDB and Swissprot and kinase-specific characteristics such as membership to a specific group of kinases, annotations of disease associations extracted from GO terms and mapping of PFAM domains, and relevance of the residues for the differences between groups of kinases. In addition to the predictions, wKinMut offers a number of integrated complementary services that help to understand the consequences and the mechanism of the mutations. These services include the classification of the kinase, information about associations of the kinase with other proteins extracted directly extracted from the Medline abstracts, the mutations on the corresponding protein structures, and possible relations with pathogenicity recorded in disease-variation databases and from large-scale cancer studies. An important component of wKinMut is the access to information about the mutations extracted directly from the literature. This information is important for the contextualization of the consequences of the mutations. wKinMut uses our previously developed SNP2L [25], that has been shown to provide a substantial addition to the information provided by public databases and repositories.
In summary, we think that wKinMut constitutes a powerful one-stop shop for the study of the potential pathogenic potential of mutations in protein kinases. As such, wKinMut will be of interest for bioinformaticians and computational biologists that can use the information provided by the server programmatically as part of their own analysis pipelines, and it can be also useful to biologists and clinicians who can browse and explore punctual information easily from the provided interface. We have used wKinMut during the past year for the analysis of the consequences of mutations in the context of a number of personalized cancer genome projects (see [41]), including the recent analysis of Chronic Lymphocytic Leukemia cases [42,43].
A further development of the presented system would consider the analysis of the downstream consequences of mutations in relation to potential and known post-translational modifications and their interelations (see [44,45]). We are interested in extending wKinMut capabilities to the analysis of the combined effect of mutations in pathways and signalling networks in where kinases are essential components wKinMut is publicly available at http://wkinmut.bioinfo.cnio.es webcite.
Competing interests
The authors declare that they have no competing interests.
Author's contributions
AV and JMGI designed the experiment. MV, JMGI designed the web server. MV, JMGI and AP implemented the web server. JMGI, MV and AV wrote the paper. All the authors read and approved the manuscript.
The authors thank the members of the Structural Biology and Biocomputing Programme (CNIO), especially A. Rausell, D. Juan, I. Ezkurdia and T. Pons, for interesting discussion and comments on this manuscript. This research was supported by OpenPhacts European project (115191-2) and Spanish Ministry of Science and Innovation project BIO2007-6685.
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30cc Slick 540
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My first gasser, a Redwing RC Slick 540. Has a DLE30. Servos: HS7955TG all around, with HS7985MG for the throttle. VVRC 20x6 wood prop. Receiver is the Spektrum AR9110. Has two 2100mAh Life packs for the receiver and one 850mAh Life pack for the ignition. Opto kill switch from RCEXCL.
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| Dec 16, 2014 @ 03:18 PM | 1,926 Views
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| Dec 16, 2014 @ 02:56 PM | 2,001 Views
Radio-controlled radios aren't anything new. It has been around longer than I've been alive, and I was born in 1961. The first time I have heard of and seen a radio-control transmitter was back in 1973. My Dad and my brother; we would go around Torrance, Hawthorne, Lomita, Carson Mall, and Long Beach, looking in various hobby stores at model planes. Back then, I built plastic model planes (static display airplanes), flew free-flight balsa models, U-control Cox & Testors planes and model rockets. The first time I've ever seen radio-controlled airplanes flying was at a vacant field behind the Carson Mall. This was back around 1973 if I remember correctly. Some people were flying what looked like Ugly Stik planes. I was hooked, vowing to get one when I could afford it. Radios back then cost $300 and up, and that was a lot of money back then. We were at TQ Hobbies in Lomita (?), I think, and yes, $300 & up for a Kraft radio. I'm sure it came with servos, but still that was way more than what we could afford. I remember Futaba was considered the best, and to many, it still is. I was smitten by the gliders that flew out of Point Fermin in San Pedro, CA. I also saw them flying off of Bluff Park in Long Beach. My dad said if I wanted, we could save up to buy a glider and radio, but it would take maybe a year to get enough money. I knew it would have put a big strain on our finances, so I told him, no. And besides, I did not know how to fly r.c. If I
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Realflight showing double vision
Posted by
| Dec 12, 2014 @ 02:07 PM | 1,995 Views
After the automatic updates to my pc, I did not know that somehow, the NVIDIA video software had turned on the 3-D function for 3D glasses.
So what happened is that when Realflight is on, I saw double of everything, including double airplanes.
I went into the video card setting in my pc and didn't find anything broken. Then it occurred to me that maybe the 3D glasses are on. I don't use 3D glasses, because most programs don't have 3D capabilities.
In the NVIDIA settings, I found the enable/disable switch for 3D. I turned it off and went back to Realflight. Everything was back to normal
And best of all, my pc didn't overheat anymore. When it overheats, it shuts off.
Now Realflight runs fairly cool and sometimes warm in the pc.
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Charging my DJI Phantom 2 battery
Posted by
| Nov 25, 2014 @ 01:50 PM | 2,563 Views
In this blog entry, I am not instructing anyone to do this; nor is this a tutorial on how to go about it.
With the DJI Phantom 2 battery, you are left with two options: buy an AC charger from DJI, or buy their car charger. Both chargers cost a hundred dollars. They aren't really chargers; they are 12 volt power supplies.
The DJI Phantom 2 battery is a "smart battery." It has its own charger inside. It takes 12 volts DC and the internal charger does the rest.
The problem is finding a plug that fits the battery. Venom makes a set of plugs for Deans, EC3, and others. One side of the adapter plug has rounded nubs, so reversing the polarity is made that much more difficult, which is good.
I made this adapter, so that I can charge at the field. And at the end of the day, I use this adapter to discharge the battery to storage charge level.
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The adapter that I made to charge the battery from a 12 volt dc source.
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Fun Cub with Himax HC3516-0840
Posted by
| May 05, 2013 @ 11:23 PM | 3,553 Views
Motor: Himax HC3516-0840, 840kv motor, 35.2 x 42.2mm size.
13x4 prop, GForce 2200mAh 40c/3s lipo.
At full throttle: 25.8 amps peak, 278.6 watts peak, 10.8Vm, 0.16 Ap, 11.53V at lipo battery source.
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Aftermarket Tailwheel assembly for parkflyers
Posted by
| May 04, 2013 @ 04:48 AM | 2,930 Views
I just found the perfect tailwheel assembly for parkflyer planes. If you fly the Tower Hobbies F6F Hellcat, you know it could use a much more durable tailwheel. Well, I've found one from Hobby-Lobby online. It costs $4.79. The photos show what it includes and nothing more. The wheel itself is made of metal with a rubber tire.
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Goop & Welder's
Posted by
| Apr 17, 2013 @ 09:27 PM | 2,790 Views
If you like to build and fly epp planes, you would know that plain old c.a. is okay to use, and Welder's is one of the best choices to use for epp. But did you know that Goop is almost the same? The only difference is that Goop seems to be thicker than Welder's. This is what both glues look like in their tubes:
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Parkzone T28 with Turnigy D3530-1100kv
Posted by
| Apr 16, 2013 @ 09:40 PM | 2,969 Views
Re-trim not needed, even in a day that saw 20mph + winds. Using an EMP 10x7 prop, my static run-up tests show 28.88 amps peak @ full throttle, producing 310 watts. At half throttle, the motor is drawing 12.22 amps peak, and producing 136.8 watts peak. After a 4 minute test flight, my 2200mAh 30c 3s lipo (GForce) had 3.99, 3.99 & 3.99 volts. I could have flown the T28 another 2 or 3 minutes. I set my timer to 6:00. The plane "feels" lighter in the air and responsive, without feeling "out of control." I like this setup the best.
--16 April 2013
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Turnigy D3530 (1100kv)
Posted by
| Apr 11, 2013 @ 11:22 PM | 3,336 Views
This motor's been used by Bob (rgthd007) on his Fun Cub, spinning a 13x4 prop (!) and a 40 amp esc. Now, the Hobbyking website lists the maximum amps at 22, but in reality, the max is 32 amps. Bob did a power test and here are the results: at full throttle (13x4 prop) the motor is drawing 29 amps. At half throttle, the motor is only drawing an amazingly small 2.10 amps/25 watts with the same 13x4 prop! Maximum power at full throttle is 311 watts.
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MS Composit P-51
Posted by
| Feb 20, 2011 @ 09:05 PM | 4,169 Views
This is the plane that flies when it's too windy to fly. Nobody except a few
3D guys and jets show up at the field when the wind is blowing. My MS Composit Mustang is all-epp except for the rudder and horizontal stab, which are made of a depron-type foam. The fuselage is 1 inch thick epp. This Mustang's motor is from a Sky Fly Max plane, putting out 27 ounces of thrust with an 8x4 prop and 1800mah 3s lipo.
The a.u.w. for the P-51 is 13.75 ounces with the 1000mah 3s 11.1v lipo.
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Gravity Hobby Cessna 182
Posted by
| Feb 06, 2011 @ 06:29 PM | 3,347 Views
The rc hobby plane market is just full of cheap, cheesy products that could barely fly, or if it can, will only last a few flights. Now, one of my favorite planes are the Cessna high-wings. High wings in general really get my flying interest up, whenever I see one up above.
I was looking for a Cessna 172 or 182-type of park flyer; one that will fit inside my small car. This limits me to a maximum 40-inch wingspan or less. Add to the equation the need for a great-handling, high-quality, good-looking, and reasonably-priced brushless-powered airplane, and it's not that easy.
Luckily, I was browsing Youtube and came across a review for the Gravity Hobby Cessna 182. The reviewer gave it a favorable rating. He just kept saying how nice it flies, how good it looks, the battery compartment, and motor. And I was pleased to find out that the wingspan was only 35".
I love this plane. I never thought a foamie could fly like this. It flies like the large PZ T-28 Trojan.
A photograph of my Cessna is attached. I hope more people would find out about this plane.
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subset: commoncrawl


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Whether you are a first time buyer or seller, or have been through multiple transactions, you might be surprised by how quickly the real estate market changes in Los Altos, Palo Alto and surrounding communities. You need hard-hitting historical data, current market analysis, and insider experience to stay informed and succeed in these real estate markets.
As a service to their clients, Jeff Stricker and Steve TenBroeck of Alain Pinel Realtors provide regular market analysis and commentary. You are invited to read the entries below, add your comments, ask questions or contact them directly.
September 2012 Market Snapshot – Hot Market, Year Two
Now that we are three quarters of the way through the second year of a very hot local real estate market, we have to wonder. Is 2012 more like 2000 or 2005? Both of those years were second years of very hot markets, too. However, 2000 was the end of that hot market (the dot-com bust) while 2005 was the second year of a four-year hot market run. There is, of course, no way to know in advance. For that reason, real estate purchases and sales need to be considered long range decisions.
August 2012 Market Snapshot – Happy Days are Here Again!Share
Record Median Sales Prices in Palo Alto, Menlo Park and Los Altos Hills
If you're a seller in today's market in the Palo Alto / Los Altos greater area, you've got to be ecstatic about our local real estate recovery. Year over year median sales prices were up in August by 16% in Los Altos, up 24% in Palo Alto and Menlo Park, and up 36% in Los Altos Hills!Share
July 2012 Market Snapshot – 15 Year High in Los Altos Hills
Summer Sizzles in the Hills
While the number of homes for sale in Los Altos Hills was up by 30% from a year ago, sales were up by 50%! In fact, there were more sales (16) in July than in any other month of July in over 15 years.
2012 Mid-Year Report: Prices Are Rising, Owners Are Staying Put
The first half of 2012 was a terrific time for home owners in our area!
The supply of homes for sale was low while demand was high. Supply is primarily driven by consumer confidence. Since most owners in our area do not "need" to sell, they tend to want to sell when they think the value of their home may decline. Conversely, if they believe that values are rising, they tend to put off selling. This is what is occurring now. Prices are rising. Owners are staying put.
May 2012 Market Snapshot – Surge in New Listings!Share
The number of new listings of homes for sale jumped in May. Many sellers had been waiting for the highly publicized launch of Facebook's IPO to put their homes on the market. Fortunately for those sellers, the standing pool of buyers was deep enough to keep prices high in spite of the surge in new inventory. How long the number of buyers will keep up with the bump in supply is anyone's guess. We believe it will have mostly to do with consumer confidence, as always. However, if we were planning to sell within the next year, we'd would do it sooner rather than later. Read the rest of this entry »Share


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Monday, February 20, 2006
Twizted Paradise
I know there are times when I'm thinking about the future of candy and I say to myself, "why can't red vines be more like string cheese?"
Well, Twizzlers has answered the call of curiosity: What would happen if you made red licorice in the string cheese format?
First, it'd be pretty. That's part of why I bought this, it was so cute. It looks like telephone cable! But it doesn't taste like it. Second, it'd be interactive. The candy is basically red licorice laces twisted together and lightly fused into short ropes. There are three colors of the laces: red, orange and yellow.
This flavor is called Paradise Punch. I was hoping that each of the strands would be a different flavor, but it didn't taste that way. They were all that typical red fruit punch flavor. What was rather overwhelming was the chemical taste, like plastic or some sort of volatile compound. The lingering chemical smell and taste just left a bad taste in my mouth. They were soft and chewy, just not tasty.
I tried taking it out of the package (in case it was the wrapper) and leaving it out for a while, but that didn't seem to make the flavor dissipate. Which makes me wonder if that's how it's supposed to taste. I actually do love Twizzlers and maybe if I see the regular red flavor (or a Twizted red and black) I'll give it another try. For now, I'll have to pass on the chemical cocktail.
Friday, February 17, 2006
Hard Candy: Juntsuyu
There are some candy aficionados who turn up their noses at hard candy. Sure, they might think a candy cane is nice as decoration, but certainly not meant to be eaten and savored. I actually like hard candy a lot. I like Lifesavers (or did until they mucked around with the flavors in the standard five flavor roll), I like starlite mints, lemon drops and I love barley sugar candy. When I saw these at the Japanese market, I was hoping they were barley sugar, though it didn't say that was part of the ingredients. In fact, I'm not sure what they are except for solidified, cello-wrapped heaven.
These little morsels look like drops of honey. There are two flavors, the golden ones and the darker ones. I have no idea what flavor they are, but the dark ones taste like sweet black iced tea. The lighter ones taste like sweet sugar with a hint of jasmine. The little bottom of them forms a pentagon and has a little hole in it. There are virtually no air bubbles or voids anywhere in the candy, which makes them exceptionally smooth.
The little cones (about one inch tall) fit nicely in the mouth and have no sharpness to them that can cut the roof of your mouth, which has always been the danger with cheap sour balls. These dissolve slowly and release a delicately sweet flavor across your mouth that will linger for hours after you eat them. They're crunchable too, as I am prone to chewing up my hard candies. The black tea ones (which I've already eaten all of) have a strong tea flavor to them with not a hint of bitterness. The sweet aromatic jasmine in the light ones (or whatever flavor it might be) is clean and fresh.
For some reason these were strangely expensive. At $2.29 for a scant three and a half ounces, I've gone and gotten myself addicted to some pricey boiled sugar. The brand, Shirakiku, is known as a tea and snack brand in Japan and to many Americans who buy Japanese teas (like my favorite Genmaicha) and those seaweed rice crackers. I have not been able to find anything about this candy anywhere online, though it's possible that the English word "juntsuyu" isn't quite accurate (as is often the case with the American labels slapped on the back of these import packages). So if any of my sweet Japanese readers can help me figure out what these are, I'd be ever so grateful.
UPDATE 4/18/07: JBox is now carrying Juntsuyu (at my request, thankee-thankee). For the record, since I did this review I've eaten three more bags of these and also put them in the Christmas Stockings last year.
POSTED BY Cybele AT 9:40 am
Thursday, February 16, 2006
SweeTarts Rope
There are a few new red licorice products out lately. Both Twizzlers and Wonka are in on this new explosion, perhaps fueled by Airheads' new products.
The SweeTarts rope is one of those new products. Kind of like the Twizzler Twerpz, these are a cherry red licorice tube filled with a blue, sour paste which is then dotted with little crunchy Nerd bits.
The texture mix is really interesting. You have the rather bland chew of the licorice, which is soft and clingy. Then you have the soft, frosting-like sour paste that doesn't have much flavor in it's own right, but has these little crunchy bits that are powerfully packed with more sour.
I tried eating this several ways. I tried the traditional bite and chew method, which mixed the flavors and textures and variations of sour and sweet very nicely. Then I tried squeezing the rope until the blue sour paste came out. That wasn't as satisfying because I couldn't get most of the paste out that way.
I was tempted to find a sharp knife and slit the straw open and scrape out the blue goo ... but then I thought that was a little too evil and I just ate the rest of it the normal way.
The photo on the package of the cross-section shows colored Nerds in there, but I think they kind of dissolve after a while.
I think this is a fun new candy and I'd probably eat it under the right conditions, but in order to get me to buy it again, it's gotta come in a citrus flavor variation. Given the choice, the Twerpz are gonna win out. I like the filling in those a bit better (it's more like a Starburst fruit chew).
If you've tried them and want to tell Wonka what you think, they have an online feedback survey. This product was manufactured in New Zealand. I don't think I've picked up a Nestle product in a long time that was actually manufactured in the United States. On another strange note, the Rope was rather hard to photograph. Something about its matte texture just sucked the light in and gave it this weird velvety look in the photos. They're not really that alien looking.
UPDATE 4/5/2009: It appears that the SweeTarts Rope has been discontinued. However, Nestle is introducing a new product called Kazoozles that looks an awful lot like these. Keep an eye out for them.
Related Candies
Wednesday, February 15, 2006
Java Bark
I bought this tin of Java Bark on sale just after Christmas from Crate & Barrel. At only $4.50, marked down from $15.00, I couldn't resist. Besides, I was buying some Mint Cookie Joys, so the shipping was a done deal.
I wasn't quite sure what Java Bark was going to be, and it's not quite what I was expecting. I didn't know if was going to be chocolate or toffee or good. And it was none of those things.
Basically it's a sweet coffee flavored "chocolate" with chocolate cookie chunks in it sprinkled with a coffee powder and then drizzled with some white chocolate. They're cut into squares (about 2") and individually wrapped. Then they're tucked into a pretty oval tin.
Did I mention the tin is really pretty?
The little plastic wraps are incredibly hard to open for some reason, which leads me to believe that these are not made by Harry London, who made the Mint Cookie Joys, because those little cello sleeves were easy to open.
Once open the squares have a very sweet, coffee smell to them. The "chocolate" has a rather graham flavor to it, a bit grainy and after looking at the label, I see that it's not really chocolate at all. The cookie bits are firm and crunchy and actually really good, mostly because they add a dash of salt to the sweet and chalky combination. The coffee powder (coffee grounds) gives the whole thing and unpleasant grain but a good boost of flavor.
The nicest thing about these is that I can bring them to work and set the tin out and no one will think I've pawning off Christmas candy on them. And that's just what I'm going to do. I've gotta make room for the Valentine's sale candy.
Tuesday, February 14, 2006
Head to Head: Rolo vs Caramel Kisses
There are a lot of new Hershey's Kisses out. Some of them are natural progressions of the classic milk chocolate morsel. Dark Chocolate and their sassy purple foils are one of those and of course Hugs with their almond centers. Some of the new Hershey's Kisses sound like pre-existing products in the Hershey's repertoire. When I heard about the Caramel Kisses, I thought, "Aren't those just Rolos?"
Rolos have been around in the United States since 1971 and I think I remember their introduction. I also remember some of the other advertising campaigns, including the Rolo song (You can roll a Rolo to your pal/it's chocolate covered caramel ... you can roll a Rolo to your friend/it's chocolate covered caramel from end to end). They've never held much interest for me, I enjoy eating them with other things, like pretzels or apples, but not just as a treat by themselves.
The Caramel Kisses are soft, flowing caramel in a molded chocolate shell shaped like a Kiss. Rolo is a soft but chewy caramel in a molded chocolate shell shaped like a tall disk.
The chocolate on the Caramel Kiss is sweet and likable, with a fair amount of grain and that inimitable Hershey's tang to it . The caramel is flowing and sweet with only a slight toasted sugar note to it. The vanilla is rather chemical in nature. They're a good size and have a good proportion to the elements.
The Rolo has a very sweet chocolate outside, with a fair amount of grain and a sort of "graham" taste to it. The caramel inside is pleasingly soft but not messy and flowing. It's chewy without pulling on the teeth. It doesn't have much flavor to it, not much of a toasted sugar note, but it's smooth and milky. They smell of sugar and fake vanilla.
Frankly, neither of these candies float my boat. I know that in a Head-to-Head the battle is supposed to be fierce and the winner takes a huge prize, but I'm just not fond of either of these candies enough to purchase them again. Instead it's one of those board games that you start and it gets so complicated or boring that you just agree to wander away.
Monday, February 13, 2006
Orange Blossom Chocolate
Sometimes it's packaging that keeps me coming back to a product line.
I just love these little cans and medallions of chocolate. I'm not fond of the price, but in this case it was a gift. It's the last of the flavors from Splendid Specialties that I needed to try. Tea is pretty high up there as a flavor in my Pantheon.
The disks of chocolate are wrapped in orange foil and stamped with a little leaf emblem. The chocolate is sweet and milky and has a strong but still soft orange component. The black tea flavors come from actual black tea leaves in the chocolate. These aren't terribly distracting from the smooth quality of the chocolate but they do provide a fair amount of grit from time to time.
What I appreciate about this combination is that there's no clove in there. Most orange/tea combos end up with clove in the mix, which I just don't like.
The tea flavors linger in the mouth in a good way, but I think I still prefer the Jasmine one I tried first last spring. The packaging makes it ideal for carrying on trips because it can't get crushed easily. Or perhaps put it in a picnic basket - there are six pieces in each little can and it's resealable. I wish Splendid Specialties would tackle dark chocolate. I think all their flavors would be equally compelling mixed in some smooth and bitter Belgian chocolate. But let's face it, this is special occasion chocolate, at $3.00 - $3.50 for ounce and a half, I'd rather get a Dagoba bar.
For reference I tried Jasmine Green Tea Chocolate (8 out of 10) and Emperor's Ginger Tea Chocolate (7 out of 10).
Saturday, February 11, 2006
Caffarel Gianduia 1865
Everyone's talking about Valentine's candy. But I thought I'd give you a taste of a few other seasonal treats instead. Yesterday it was candy to watch whales by. Today it's Olympic candy. A friend of ours, Matt, was working in Torino for the Winter Olympics on the Canadian Pavilion and just returned. He was thoughtful enough to bring back some candy, and this Caffarel Gianduia is "officially" branded Olympics merchandise (it even has a hologram seal!).
These little cuties are packed in a clear cello bag, each piece wrapped in gold foil, marking the Torino 2006 Olympics. The pieces are shaped like little old lady handbags and are about two bites each (or you can put it all in your mouth, don't let me stop you).
Caffarel is the chocolate of Torino, so it's a natural fit. And if I do say so, I think this is a sporty chocolate. What I found particularly fascinating while browsing the Caffarel site was the story of how they invented this gianduia chocolate. Back in the 1860s cocoa was rationed, so Caffarel figured out a way to create a chocolatey confection that didn't feel skimpy. This gianduia contains 28% hazelnuts! The wondrous thing about combining the chocolate with hazelnuts is the soft feel it creates on the tongue. It's sweet, without masking the chocolate and nut flavors. But very sticky, consider this the Italian version of peanut butter sticking to the roof of your mouth.
I was also happy to try these because the last Caffarel bar I had to try had bloomed and I'd heard that this was an excellent Italian brand. I can see why now. Tasting these little morsels has also made me crave their darker sisters called Gianduiotto Fondente, which is made without milk.
If you've ever had Ice Cubes and are looking for a more sophisticated version, especially one without the addition of hydrogenated oils, this might be it. Soft, nutty and sweet with that slight cooling sensation that makes me pop another one in my mouth, just to make sure they all do that. It'll be a sad day in my house when these are gone, and that'll probably be soon, I can't risk them melting in this freaky heat wave we've got going on in Los Angeles right now.
POSTED BY Cybele AT 2:40 pm
Friday, February 10, 2006
Swedish Aqua Life
When I was in college I would pick up a quarter pound of mixed color Swedish fish at a little coffee shop on campus. They would put them in a crisp white paper bag and I learned that I had some sort of special power that I could pull out any color on demand without looking. It was like I could see colors with my fingers, or maybe my hands had a nose. Anyway, the best part of this trick was that people would like to see me do it, and I would make them provide the bag of fish. I had a rate of about 80% correct guesses.
This new Aqua Life set makes my old trick irrelevant as this mix has a different shape for each color. Unlike other red flavors that I don't care for (cherry), the red Swedish fish is something else, I'm guessing loganberry. Also, there are two new flavors/colors in the fish family: blue and purple.
Yellow (Lemon): Starfish
All of the candies were soft and chewy and the flavors were solidly good. They're smooth, sweet and fragrant without much of a tart bite. They tend to stick to your teeth, but not in a tooth-yanking way. The shapes are also fun and easily identifiable, which makes them fun for kids (as if you really need to do anything to make candy fun for kids).
It's interesting to note that the Swedish confectioner, Malaco, that originally made these invented them for the American market. Which explains why the fish have "Swedish" stamped on their backs (instead of Swedensk or whatever the Swedish word for Swedish is). They've only been around since the mid-seventies, but it's one of those candies that has a timeless feel to it.
The reason I was drawn to them in the first place is because of my whale watching trips. I've been taking little candies with me (we've had a lot of kids on the boats lately) which help to calm queasy stomachs. I was hoping to find something that fit with the sea adventure theme and these fit the bill (I've been carrying individually wrapped lifesavers as well). If I can find them in bulk, I might buy a pound and carry them in a little ziploc bag so the kiddies can pick their favorite shape.
The package states that these candies were made in Canada by Cadbury Adams but licensed from MalacoLeaf, Sweden. So, are they Canadian fish?
I would have given them a 10, but there were some manufacturing defects in my bag, with some overstamps and some little bits that didn't seem to belong (extra pieces of orange hanging off the seahorse). These may be a good candy for vegetarians (as long as they're okay with traces of mineral oil) since there's no gelatin, just corn starch.
Page 219 of 252 pages ‹ First < 217 218 219 220 221 > Last ›
Meticulously photographed and documented reviews of candy from around the world. And the occasional other sweet adventures. Open your mouth, expand your mind.


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Student Summer Research Projects
Research Opportunities at Grinnell
Current MAPs (Summer 2013)
- Prof. Chris French
Title: Noncommutative, Imprimitive Association schemes of Rank 6
Research Opportunities at Grinnell
Current MAPs (Summer 2013)
- Prof. Chris French
Title: Noncommutative, Imprimitive Association schemes of Rank 6
Representatives from Nationwide Insurance will be on campus Tuesday, Sept 17 to discuss the actuarial profession and recruit for summer internships or careers. There will be a MASSS with the representatives, at noon in Noyce 2022 , and there will be individual meetings to talk to them in the afternoon. They will also have an all-campus presentation on the actuarial field at 4:15 PM in JRC 209.
New book helps students understand difference sets with tools from geometry, number theory, and representation theory.
Major requirements and course descriptions are available from the College Catalog.
WIth statistical modeling, new textbook gives students a powerful and flexible approach to a wide variety of data.
- The Mathematics Local-Area Network (MathLAN)
Daubechies explains how wavelets were used to detect fraudulent art, capping a semester of fascinating speakers.
Jeff Blanchard and his Oxford collaborator Jared Tanner release compressed sensing software.
Professors Jeff Blanchard, Joe Mileti, and Jen Paulhus spent some, or all, of spring break working on research outside of the United States.
Jeff Blanchard visited a collaborator in Edinburgh for a week of intensive writing for an ongoing project. The trip to Scotland paid off with a 50 page paper submitted at the end of Spring Break.


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Top-ranked recipe named "Starter- Bruschetta"
Try this Starter- Bruschetta recipe, or contribute your own. "Summer" and "Meatless" are two tags used to describe Starter- Bruschetta.
"Very good! I added cooked bacon and fresh parsley as a garnish to mine! "
In a medium bowl, mix tomatoes, dried basil, Parmesan cheese, olive oil, garlic, and season with salt and ground black pepper. Cover and chill in the refrigerator 8 hours, or overnight, before serving.
|My private notes
Get the free BigOven app on your phone.
Quickly find any recipe anywhere!
amineemami 1 year ago
mamawisch 1 year agoVery good! I added cooked bacon and fresh parsley as a garnish to mine!
katehandel 6 years ago[I made edits to this recipe.]
katehandel 7 years ago[I posted this recipe.]


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Jessica's Horse
A Saturday afternoon call to the police department complained about a couple screaming at one another. The dispatcher sent a unit to check on a possible domestic violence situation. Alcohol was involved, as it often is, but when they ran a check of the father they found two warrants for possession of drugs. The mother, really only a girl ...Full Article
Equine Cruelty Investigations
Equine Cruelty Investigations – The Horse By Pat Raia • Oct 01, 2012 • Article #30921 Veterinarians and animal welfare organizations help law officers investigate equine cruelty cases and ...Full Article


text: Orle Gniazdo recently hosted our group of 14 American high school boys, plus a number of adult chaperones. The hotel provided our group with several guest rooms, a wifi ready classroom, two bonfires on the patio, a party in the disco, and several meals throughout our trip in the restaurant. The guest rooms: I stayed in a larger room on... More


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All members are expected to contact the Executive Board or relevant committee any time they believe they have a disagreement, or grievance involving contract, policy, or law. It is unacceptable for members to make contact with, enter into negotiations with, or try to influence Fire Department Administration, or City Administration involving the above matters. The Exectutive Board, or designated Committee, through the E-Board, will make any and all contact with management in all matters relevent to the Local and it's members. Department business unrelated to union matters should obviously go through the proper chain of command.
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Brian Reindel
In summary I am a Christian, husband, father of two adopted children (Guatemala and Korea), and a software developer immersed in Web technologies for almost 15 years. I have experience leading projects on various technology fronts, including Java, .NET (C#) and PHP, and I've used MySQL, SQL, PL/SQL and Oracle for relational database development. I'm currently immersed in Java EE and the Spring Framework, and I enjoy working most with the Java technology stack.
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Personally I don't find Brookes Jensen to be too evangelical of digital methods. I'm assuming this was the problem. In this Blog I think he was only making comment about an epiphany he'd had when thinking of how things have changed, particulary in the efficiency of his printing process. Perhaps I've oversimplified it, and there are greater things at work here (?)
The [color=black][font=Times New Roman][font=Verdana][size=2]philosophical approaches he employs in editing his magazine are what really count for me, and as a result in my opinion Lenswork is a very good magazine.[/size][/font][/font][/color]
[color=black][font=Times New Roman][font=Verdana][/font][/font][/color]
[color=black][font=Times New Roman][font=Verdana][size=2]He makes no secret of his use of digital methods, and advantages that brings him. Do you think he should?[/size][/font][/font][/color]


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Letter: What is done with traffic reports?
Roger Giles, Knoxville
I appreciated the letter relating to the "single-digit" driver who was texting and speeding. This was a good letter and at the opposite extreme of describing the many drivers we see who are on their cellphones driving slowly and completely oblivious of their surroundings.
I liked the writer's claim he had notified the Knox County Sheriff's Office and the Tennessee Highway Patrol of the vehicle's license number, which brings me to my point: What do they do with reports like this? I'd say a "be on the lookout" is in order and a tail-light check performed if located, at least. Considering that about 20 percent of the cars on the road have a required brake, signal or night driving light out, the chances are good the abusive driver could be cited for something and warned about texting or cellphone use effecting their driving abilities.
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So sorry about your southern cousins!View Thread
Yep, brew_fool, you were very right, I love this one!!! $20 a day??? Most need twenty an hour, or less?! LOL!!!
I smell a big phony!!!! Another scumbucket tired of living in mommies basement, so he pulls this stunt? This is the real reason they want us off of what works! Idgits suing their Dr.'s who are trying to help them?
If these wanna be millionaires keep this up, even the Great and Powerful Ozbama couldn't stop them. LOL!!!
Thanks brew_fool! I did indeed love that one!!!
D.View Thread
Getnhealthy has some good ideas! I go along with her on seeing your Dr. again! This time, don't take no for an answer. You need to make up a schedule, or a diary of when the pain occurs, how often, how much pain it causes on the scale of one to ten, ten being horrible, no can take pain? Know what I mean? And be sure to write down any questions you can think of, or at the time it hurts, how much it hurts, etc.
I think you may have an inside issue? Uterus, tubes, etc. etc.? I heard of something just like this? After doing those tests, they found out she had an infection in he uterus? Tubes? Something female organ? LOL!!! I surely cannot name them all right off the top of my dead head! LOL!!!
I hope you find what you are looking for right here? Maybe not in the something I say, but in someones response to you?
I wish you great luck!!!
DennisView Thread
Hey, this may not work for you, but it did for me? I went in to the V.A. hospital in Neb. and as I was talking to my new Dr. I started screaming help me, please someone please help me? The pain is unbearable!!! Etc. etc. She was loathe to put me on narcotic drugs so she used the Tramidol. Well, as I was walking back home, I started to "UN_THINK"? I couldn't hold any conversation with my best friend? I called her right then and there and told her how this drug was effecting me? She asked if I could turn around and come back? No, not walking anyway, so I took a bus. She gave the pharmacy a script for me of Methadone. Plus, for breakthrough pain oxycodone 5mg.. That was awesome, the way the pain melted away to the background?! Oh, I still felt the burning sensation in my arm, but this was waaay better than Ibuprofen!!! Slowly I went up on doses as I got used to them, and once I hit a 1000mgs. a day, she switched me over to Morphine e.r. 100mgs. three times a day. Plus the oxycodone. Gradually I went up to 700 a day, and the oxycodones. After I got used to this, my now pain doc let it ride there and added Lyrica for the burn. This all felt okay. After a while tho, it stops working so, I asked the doc if I could go back down to the 400 range? Oh yes, he agreed right now, all because of this new congressman Dr.? Well, he must think he is a doctor the way he is making everyone in the V.A. system wean off of the narcotic drugs? I will skip the weaning down to 400. I have been at that same dose ever since
Yep, they considered all of those suicide death were all because of the narcotic drugs? Well, after survey after survey they were proven wrong, but that didn't stop ole congressman Dr. No way, this will be his signature accomplishment! Plus, he doesn't suffer from the pain and agony we feel every day, some of us ALL DAY & NIGHT!!! Damned RETHUGLICANS!!! All they care about is their bottom line! Or, their corporate masters? My guess is; Big Pharma has some other, more expensive form of treatment going? That is why they ALL want us off the narcotics!!!
Steven, I am so sorry if I bored you? I get kinda windy sometimes? The community would tell you it is all the time. LOL!!! I hope you can get the relief you need, or surgery should still be a last resort?! My neck is full metal now, someday, I too will need surgery on the small of my back with my degenerative disc disease? I hate surgeries, but sometimes, we have to do what we have to do!
I wish you the best of luck!!!
DennisView Thread
WE are ALL in BIG TROUBLE!!!
DennisView Thread
You need to get with a Pain Management Specialist!!!
One of the good ones will have you right in less than two weeks!!! ASK your Primary Care Physician for a referall? He should be aquainted with at least one? Do this for YOU, not your hubby, not your great aunt Millie, no one but YOU!!! This IS YOUR PAIN, not anyone else! Get one pain doc. to help, if he fails you, find another till YOU get the HELP YOU NEED!!!
One good pain doc. is worth more than all the gold in Fort Knox!!! I know, I suffered long before I realized what I needed went far beyond what my doc. knew about chronic pain. Only one that has extensive training on chronic pain, will be able to help you! And in the right way, too!
To find the help you need, if your regular doctor does not know of one, ask at the front desk, or go on-line and find one practising in your area, and make an appointment! Look in the phone book, who knows, one might be in there?
I want to wish you luck!!!
DennisView Thread
I take morphine 100's four times a day, now. I was up to 7 hundred's a day, plus my oxycodone for breakthrough pain. I was told a withdrawal from these would be a nightmare? I believe this because my dr. once forgot to renew my script before she left for a two week vacay? I was going nuts by the end of the first day off!!! The morning of the second day, after a night of tossing and turning, I went to the V.A. hospital in Omaha. The nurse told me I would have to wait for my pain dr. to write the script? I told her there was no way I was leaving without my morphine! A doctor showed up, told me the same thing the nurse said, I told him the same thing I told the nurse! Well, after a war of wills, the dr. went and found someone to write a script for just long enough for my dr. to return. Thank you, that was all I wanted, good day Trust me, I know what you are going through!!! I feel so sorry for you, and me now, cause I can't help you?!
The only thing I can tell you is this; try using C.B.T.? Have you heard of this? It is cognitive behavioral therapy. Try concentrating on an object, make that object all there is. Try deep breathing for a minute first, just to relax, if possible? This is going to be difficult, but what the mind can conceive, the mind can achieve! You have to believe it will work or you won't get it? I quit smoking that way, and I am still smoke free! Any time I felt like having one, I would deep breathe for a couple minutes, and think of how nice it was to breathe this way, and I wouldn't have one?! You CAN do this, your mind knows this, but your body is dictating to your mind that you need drugs? Reverse that, and you will not want those drugs, at least not until you can get some? It can work, I know it can, you have to believe in you!!!
I hope something in here will help you out, even if only a bit?!
Best of luck to ya!!!
DennisView Thread
I used to take Ibuprofen 800 two at a time, four times a day, and it must have done something to my liver, the doc. took me off of it quite suddenly? And he would never say why, exactly? Well, I asked my V.A. doc. and she said it looks like it was starting to effect your liver? It is okay, now, I guess? All the blood tests come back great? Sooo? I will have to ask my doc. today when she calls? Thanks for that tip!!!
Wow, this last one was on my c5-c6-7. That makes me a full metal neck. LOL!!! My first two were killers. And everyone from my nurse, to the surgeon were telling me that this one, would top both of those, hands down?! Well, I guess they were all wrong? That dr. that surgeon that did my surgery, was there when I had my sutures removed. He asked me how it felt, and when I told him I felt much better, he looked shocked? I told him except for the tightness and swelling, it feels pretty good? He was smiling so brightly, I swear he glowed?! I told him that, except for that, the limited movement was way more than I expected? He said I tried to give you what your degenerated discs would allow, so its a plus, then? I said you got that right, doc.! He grinned, shook my hand, gave me a slip for rehab, and said I will see you in a couple more months. Great! That was on the 16th., and I still have no okay from the V.A.?! Par for the course with them!
Well, Annette, there you have it, the whole story! LOL!!!
You take good care, talk more later,
D.View Thread
Its good to post, again! And so far, everything is looking good. I was pretty scared going in since even the surgeon said I would have a lot more pain this time, than the last two from the front?I had less pain, and this one from the back of my neck? I looked through the double mirror system, and the scar is looking pretty good?!
I do have some movement limitations, but better than I ever expected! And the best part, the bones are no longer grinding on each other? That was sooo creepy, just the feel of it? There are soft discs in our necks for a reason, to keep the bones from grinding on each other. LOL!!! I most definitely have a full metal neck, now.
How are you getting along, Dave? Any better, or any better relief since last I was here? How's the wife, the family? All great, I hope?! I lost my father Sept. 23rd. 2013, not sure if you guys knew, or not? Well, that is it, no more parents or grandparents left. I am down to one aunt left, and two uncles. After that, it is just us "kids"? LOL!!! At 56, I sure don't feel like no kid! LOL!!!
You take care, talk later,
D.View Thread
D.View Thread
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Joel Jordan on January 17, 2007 at 15:20:32:
In Reply to: Re: 80's Board Game : Fantasy/Adventure posted by James on October 14, 2005 at 23:12:23:
: HI there:
: I think the first game is Key to the Kingdom.
: I have one for sale.
: The second game sounds like Fireball Island.
: If you're interested in Key to the Kingdom email me directly at email@example.com for more info.
: James.
: : Im looking for two games:
: : The first is a fantasy game that involved going through a portal and then the game board flips open to another section the world. Involved dragons and demons. dice and cards.
: : the second is an adventure game that involved going through mountains and a volcano has red lava balls (marbles) that you send down to hit the explorers.
: : Any help would be apprecited.
And here are some Fireball Island (if any) for auction on ebay:
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text: Luke Bryan Gears Up For Bowhunting! [VIDEO] By Clay Moden October 21, 2011 7:02 AM Share on Facebook Share on Twitter Here is yet another reason I think Luke Bryan is so great. he used his weekly video to show off his archery skills!Great job Luke! Good luck hunting this year! Filed Under: luke bryan | nl Category: Clay, Dale and Liz Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of WYRK Recommended For You Best of the Web


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As I begin my new life as technical director of the Radiant Professionals Alliance, hereafter referred to as the RPA, I find myself surrounded by some very professional people who all have one goal in mind. That goal, if you will, is to "Grow Radiant." That has always been the goal of the RPA since its inception back in 1994. And although the original concepts of delivering radiant comfort were essentially hydronic based, today it includes electric panel radiation, hydronic powered radiation, and even direct and indirect gas fired radiation.
One of the most comprehensive solar hot water manuals available, this book covers everything you need to know to become...
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Repeal, Don't Reform the IMF!Written by Ron Paul
A responsible financial institution would not extend a new loan of between 17 and 40 billion dollars to a borrower already struggling to pay back an existing multi-billion dollar loan. Yet that is just what the International Monetary Fund (IMF) did last month when it extended a new loan to the government of Ukraine.
Many students have come to believe that a college degree automatically provides the graduate with an open door to a good-paying job in the student's field of study. But what's the reality?
Given that Al Gore's An Inconvenient Truth often reappears as media talking points, The Global Warming War was made to overwhelm the alarmists with science.
"Skip the preaching, Howie! Just give me my blankety-blank cup of coffee."
That was the reaction of many Starbucks customers when they learned that their morning cup of caffeine was going to be accompanied by an invitation to chat with their server about race relations in America.
Is "Income Inequality" Unfair?Written by Ralph R. Reiland
Income differences can be the result of something other than capitalist greed, racism, sexism, union busting, gluttonous stockholders, globalization, imports, automation, or the grasping shenanigans of the top 1 percent.


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Treasure Coast lawmakers rush to get bills passed in last week of session
TALLAHASSEE — With one week left before the end of the legislative session, lawmakers have had marathon meetings to pass a series of bills.
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Queen of Darkness Large Messenger Bag with Leather Buckle
(approx. $70.82 or €64.14)
- In Stock
- Usually Ships in 1-2 Days
- UK & Worldwide Delivery
- Product Type: Messenger Bag
- Size: 36cm x 36cm x 12cm
- Product Code: 70392
This gothic gem will make a great addition to your accessory collection! Featuring a leather buckle, this black canvas bag will go hand in hand with your alternative wardrobe! Ensure you have your essentials with you at all times with this bag that lets you take a walk on the darkside.


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Will knowing the future be a blessing or a curse? The mysterious game from Level 5 finds a home on Nintendo's 3DS!
Views: 13,008 | Posted: 10/20/2010
By: shir1
This is the english translated trailer of the upcoming 3DS game Time Travelers. Translated by: http://grownupsinspandex.blogspot.com
Views: 774 | Posted: 11/07/2009


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Capital Markets
Company Overview of Redpoint Ventures
BOARD MEMBERS AFFILIATED WITH Dean A. Gilbert *
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MOST CONNECTED PEOPLE TO Dean A. Gilbert
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