text:
Whirlpool Whispure is CR's top-rated, portable filter purifier;
Two ozone generators deemed Not Acceptable
YONKERS, N.Y., Nov. 5 /PRNewswire-USNewswire/ -- In its latest tests of air purifiers, Consumer Reports' experts concluded that products that draw air through fabric filters are among the most effective at removing dust and smoke. And, unlike some other kinds of purifiers, they do not produce any irritating ozone.
While ozone in the upper atmosphere protects people from the sun's ultraviolet rays, ground-level ozone is an irritant that can aggravate asthma and lessen lung function. Studies also suggest that ozone creates other irritants as it reacts with household products such as scented cleaners and air fresheners. Among these irritants are formaldehyde, a carcinogen; and acrolein, a toxic irritant found in cigarette smoke.
Consumer Reports tested portable air purifiers, furnace filters, and professionally-installed whole-house purifiers, as well as two portable ozone generators for a report in the December issue, which goes on sale at newsstands November 6.
Whirlpool's Whispure AP45030S, at $230, is Consumer Reports' top choice among the 27 portable filter purifiers that were tested and rated followed by the Kenmore Progressive 83202, at $270. The highest rated models did a better job of cleaning at their lowest, quietest speeds than many others did at their higher, noisier settings.
Among whole-house air purifiers that don't produce ozone, the Lennox Healthy Climate HC16 was CR's top choice among professionally-installed filter systems; it was also a CR Best Buy at $350. The Healthy Climate system uses non-HEPA filtration and emits no ozone.
Two do-it-yourself furnace filters --- 3M Filtrete 1700, at $20, and 3M
Filtrete Ultra Allergen Reduction 1250, at $16 --- did nearly as good a job
at removing dust and are a simple, inexpensive upgrade from a standard
furnace filter. But they aren't the best at rem
|SOURCE Consumer Reports
Copyright©2007 PR Newswire.
All rights reserved


text:
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*Calls to this number cost 13p a minute plus any additional charges from your phone operator
London Marylebone is just 30 minutes away, but the Chilterns are even closer. A stay at Premier Inn High Wycombe Central puts you in touch with all the thrills of the big city and all the hills of the chalk escarpment.
Get a soaking on Legoland's wet and wild water rides. Or get about in style at Marlow Regatta. Walk back in time at the magnificent Hughenden House, or never walk alone at Wembley Stadium. Our friendly team will help you enjoy your stay to the full and our spacious rooms and extra-comfy beds will have you relaxing into the land of nod in no time.
Calls to this number cost 13p a minute plus any additional charges from your phone operator.
Premier Inn lines are open 24 hours a day, 7 days a week.
The Customer Contact Centre is open 8am to 10pm Mon - Sat & 9am to 10pm on Sun.
Tel: 0871 527 9222
Full and Continental breakfasts, a hearty evening meal, a light snack or a relaxing drink. At a Thyme restaurant you can enjoy it all at reasonable prices.
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* Premier Offers terms and conditions
Advertised rates are room only inclusive of VAT. Bookings must be made online at PremierInn.com. Premier Saver is available for stays at selected Premier Inns only and is subject to availability.
No amendments or refunds can be made. At sites where pre payment is accepted, payment for Premier Saver bookings will be taken at the time of booking.
A £2 processing fee (€2 applies to bookings made at Premier Inn Dublin Airport) will be applied if you pay for your Premier Saver by credit card; there is no charge for payments made with debit cards.

subset: commoncrawl


text: Tammy Taylor | IBDB: The official source for Broadway Information IBDB: The official source for Broadway Information Official Broadway League sites: - sites - broadway.org broadwayleague.com broadwayfanclub.com kidsnightonbroadway.com stagespecs.org tonyawards.com Quick Search For: In This Category: All Show People/Org. Theatre Season Tammy Taylor Stage Manager Female Productions ProductionsDate of ProductionsEastern Standard[Play, Original] Stage Manager: Tammy Taylor Jan 05, 1989 - Mar 25, 1989 Find out where Tammy Taylor and are credited together © 2001-2015, The Broadway League, All Rights Reserved. (Copyright and Disclaimer)


text:
- Accessories(1128)
Results 1 - 20 of 1128 matches
Manhasset M48 Carton of 6 Music Stands
Our most popular music stand.
- 1 Open Box:
- $215.67
Top RatedBellafina ABS Cello Case with Wheels
Provides the security of a hard shell case for the price of a heavily padded bag. ABS vacuum formed case...
- 1 Open Box:
- $148.79
Top RatedFender Strat/Tele Hardshell Case
Fits Strat and Tele guitars.
- 2 Open Box:
- $134.84
- 4 Open Box:
- $194.99
TASCAM CD-BT2 Portable CD Bass Trainer
Portable, powerful learning tool.<br />Gives you the ability to slow down the speed of a CD without changing...
- 1 Open Box:
- $118.29
TonePros Standard Locking Tune-o-matic/Tailpiece Set (small...
Patented pinch freezes and solidifies your bridge and tailpiece. Stays solidly set without movement. Improves...
- 1 Open Box:
- $123.23
- 1 Open Box:
- $491.97
Top RatedMusician's Gear Folding Music Stand
Very heavy-duty for absolute stability and fully adjustable.
- 1 Open Box:
- $20.92
Top RatedFender Jazz Bass Hardshell Case
Tweed Case Jazz Bass-Features a plush interior, rugged tweed exterior, leather ends, an accessory compartment,...
- 1 Open Box:
- $185.99
- 1 Open Box:
- $175.96
- 1 Open Box:
- $349.93
Top RatedEpiphone Les Paul Hardshell Case
Les Paul Hardshell case - make sure your Epiphone is secure. Custom-crafted wood-frame cases are covered in...
- 1 Open Box:
- $83.69
Top RatedLive Wire LWS250 Universal Sustain Pedal
Operates with any keyboard that as a 1/4" jack.
- 1 Open Box:
- $26.39
Top RatedTonePros Metric Locking Tune-o-matic/Tailpiece Set (large...
Patented pinch freezes and solidifies your bridge and tailpiece. Stays solidly set without movement. Improves...
- 1 Open Box:
- $123.23
Top RatedDW 9502LB Hi-Hat Remote
Remote hi hat stand with patented cable design. Includes mounting hardware MG-1, MG-2 and SM505 Drop Lock...
- 1 Open Box:
- $343.19
Miraphone Deluxe Tuba Gig Bags
The Miraphone Tuba Gig Bags are some of the best designed bags available today. The Miraphone Tuba Gig Bags...
- 1 Open Box:
- $316.79
Primacoustic RX12-DF Mid-Field Recoil Stabilizer - 5 Degree...
The Primacoustic Recoil Stabilizer is a unique speaker mounting device that eliminates disruptive resonant...
- 1 Open Box:
- $175.99
Bellafina Pro 3/4 Size Double Bass Bag
This Pro Bass Bag provides superb protection and utility at a modest price, with dense, protective foam...
- 2 Open Box:
- $135.99
Top RatedDynasty DSPS Marching Snare Drum Stand
Very durable yet lightweight, and fully height adjustable. One leg of the stand telescopes inward or outward...
- 1 Open Box:
- $123.19
Protechtor Cases Protechtor Classic Bass Drum Case
Protechtor Cases' Classic Series Bass Drum Case provides strength, durability and simplicity for your bass...
- 4 Open Box:
- $96.79


text:
Littlemill 8 Year Old
75cl / 43%
- Lowland Single Malt Scotch Whisky
- Distillery Bottling
An old bottling of Littlemill 8 year old. The distillery closed in 1992, was dismantled in 1996 and what was let was destroyed by a fire in 2004. Today the site is occupied by a block of flats, aptly called Littlemill Court. Presented in a dumpy bottle, we estimate this dates from the 1970s.


text:
Hampton Inn Burlington
Hampton Inn Burlington
Hotel Guest Rating: 8.7/10
42 Lower Mountain View Drive
Colchester, VT 05446
Welcome to the Hampton Inn Burlington
A complimentary breakfast buffet and rooms with free Wi-Fi, plus amenities like an indoor pool and hot tub, are highlights at the Hampton Inn Burlington.
Hotel Features
The five-story, non-smoking hotel has 187 contemporary rooms featuring microwaves and mini-fridges, plus coffeemakers, hairdryers and complimentary Wi-Fi. Rooms are also equipped with 37-inch, flat-panel TVs with premium cable and HBO. An indoor pool and exercise room, a coin laundry, a business center and meeting space are also on the premises. The Hampton Inn's free hot breakfast buffet, served daily, gets rave reviews; ditto for coffee and tea available 24/7 and the complimentary cookies and milk offered most evenings in the lobby. Guests of the hotel are entitled to free parking and complimentary shuttle service to Burlington International Airport. Pets are permitted for an additional fee.
Hotel Location
The Hampton Inn is three miles from Lake Champlain, ECHO Aquarium and Science Center and the University of Vermont. Magic Hat Brewery is seven miles from the Hampton, it's eight miles to Sand Bar State Park and 12 miles to the Shelburne Museum, exhibiting 150,000 works of art and Americana in 39 buildings. Burlington International Airport is five miles from the Hampton Inn.
Guest Favorites
Priceline guests "love" staying at the top-rated Hampton Inn because of its "super friendly staff," the "terrific" milk and cookies served in the evening, and the "outstanding" and "delicious" breakfast buffet that's the "perfect way to start the day."
Hampton Inn Burlington Amenities
- Air conditioning
- Air conditioning individually controlled in room
- Alarm clock
- ATM/Cash machine
- Buffet breakfast
- Business center
- Cable television
- CNN available
- Cocktail lounge
- Complimentary buffet breakfast
- Complimentary cocktails
- Complimentary in-room coffee or tea
- Conference facilities
- Direct dial telephone
- Exercise gym
- Express check-out
- Fire safety compliant
- Fitness center on-site
- Free airport shuttle
- Free high speed internet connection
- Free parking
- Gift/News stand
- Grocery shopping service available
- Hairdryer
- Heated guest rooms
- High speed internet access fee
- Indoor pool
- Interior corridors
- Iron
- Ironing board
- Jacuzzi
- Kitchenette
- Laundry/Valet service
- Meeting rooms
- Non-smoking
- Non-smoking rooms (generic)
- On-site business center
- On-site business center is staffed
- On-Site parking
- Parking
- Parking lot
- Pets allowed
- Photocopy center
- Pool
- Public area air conditioned
- Safe deposit box
- Security
- Sundry/Convenience store
- Telephone jack adaptor available
- Transportation
- Transportation services - local area
- Transportation services - local office
- Turndown service
- Valet cleaning
- Voice mail
- Welcome drink
- Whirlpool
Hotel Information
Upon check-in photo identification and credit card is required. All special requests are subject to availability upon check-in. Special requests cannot be guaranteed and may incur additional charges. Guests are required to show a photo identification and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
Hotel Guest Reviews of the Hampton Inn BurlingtonOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
September 10, 2015
March 25, 2015
Family Traveling with Young Children
January 9, 2015
October 17, 2014
Senior Travelers
This hotel is over priced.
October 13, 2014
Family Traveling with Teens
This guest did not leave comments about this hotel.
August 27, 2014
Family Traveling with Young Children
This guest did not leave comments about this hotel.
July 30, 2014
Room was comfortable and spacious
July 15, 2014
Staff is excellent and the rooms are great. Love the location as Winooski is now a hot spot.
June 10, 2014
Family Traveling with Teens
Comfortable, met our needs.
January 1, 2014
Family Traveling with Young Children
(1 - 10 of 14 reviews)
- Quality Inn Colchester from $79 (0.2mi)
- Motel 6 Burlington - Colchester from $61 (0.3mi)
- Residence Inn Burlington Colchester from $135 (0.5mi)
- Days Inn Burlington Colchester from $67 (1.1mi)
- Starlight Inn from $79 (4.2mi)


text:
Goliath Dragon Bust Creature Sculpt 1 by AntWatkinsWatch
©2013-2015 AntWatkins
12.5" tall
Sculpted with monster clay.
I am making molds now, I will have castings available soon.
Sculpted with monster clay.
I am making molds now, I will have castings available soon.
I love how you did the skin texture!
these are quite awesome, also I noticed alot of traditional sculptors actually talk back. my goodness.
what a lovely sculpting community
I have to say, your sculptures are amazing. How long does it usually take you to finish one of these?
Thank you very much!
It varies, and sometimes I lose track of time. I believe this dragon here took around 25 hours total. He is a big boy.
It varies, and sometimes I lose track of time. I believe this dragon here took around 25 hours total. He is a big boy.
* ¡Fantástico trabajo! Lo hemos destacado dentro de la carpeta "Featured nº 4 o Destacados nº 4" en Special-Groups. (Es la carpeta donde se exhiben los mejores trabajos del grupo).
¡Por favor, queremos ver más trabajos tuyos en el grupo!.
¡Por favor, queremos ver más trabajos tuyos en el grupo!.
luv it
OMG This is so nice!
AHHHHHH OH MY GOD THIS IS INSANE!!!! HOW- WHA- HOW DID YOU EVEN. THIS IS SO EPIC I JUST CAN'T COMPREHEND!! Dude Ok first how did you do the details? like the texture and skin? Did you do all that by hand CAUSE THATS ALOT OF SCALES. This is mind blowing dude! I'm just going to crawl up in the corner over here. Don't mind me. WAIT! also how long did this take you? OK THIS IS JUST TOO INSANE I CAN'T LOOK AT IT. IT'S TOO BEAUTIFUL. You are awesome! AND STAY SHINY YOU AWESOME PERSON! *clicks fingers and points them at you*
Cool,love it!
Always loved your dragons, epic work Ant!
I see a pharoh's profile
The details look great!!I really like the direction you went on this one.
Is monster clay a good clay to work with? It seems you really prefer it and I'm interested in why
It is my favorite clay! Not messy like chavant can be, I can get MUCH more detail with monster clay, AND it comes out of the mold super clean. You really have to clean out a chavant sculpt from the mold, and with dragons in the mold, it can be very tough.
How do you make your molds? By the way I just want to thank you for always responding. It really helps and I appreciate it a lot
Sorry for the delay in my response, I make 2 part molds by making a mold box. I lay the sculpt down with a "negative" clay bed, then pour the silicone to make the halves. I have some pictures of some of the steps on my Facebook page. There are also some how to videos on the internet that some very talented moldmakers have posted.
Very nice!
How much will you be selling a raw cast ? (with shipping to France)
Would love to buy a cast. I think this is my favorite dragon bust
He looks like smirking in triumph
He looks like smirking in triumph
Thank you very much! I'll have castings ready in a few days, if you are interested you could message me, or e-mail me at email@example.com for more info on the piece if you would like.
Awesome sculpt. Love the detailing
This is incredible!!!


text:
After revenues and profits rise on the year, the estimated value of Virtu falls Read more
The publication of Michael Lewis' Flash Boys in April, 2014, generated an intense wave of publicity surrounding high frequency trading (HFT) firms, much of it unfavorable. Earlier this year,... Read more
After purchasing a traditional market making firm as part of a larger acquisition for $5.4 billion in 2000, a major investment bank is now attempting to sell it for a significant loss at nea... Read more
Virtu Financials has postponed its planned US initial public offering (IPO) after its bankers suggested that the company wait until the focus shifts away from the recent scrutiny over the bu... Read more
New York Attorney General Eric Schneiderman announced Tuesday a broad investigation into whether US exchanges and alternative venues such as dark pools provided high frequency trading firms... Read more
As reported in ValueWalk on February 25, high frequency trading firm Virtu on Monday filed for an initial public offering, seeking to raise $100 million. With a star-studded list of many of... Read more
High frequency trading is normally a private, non-disclosed business typically kept under the radar and beyond the prying eyes of regulators. But Virtu Financial is blazing new trails, fili... Read more
Flawed Fee Model Distorts U.S. Trading, Virtu's Concannon Says Read more
Knight Capital Group Inc. (NYSE:KCG) has agreed to be acquired by Getco following a highly-publicized bidding war between high frequency trading firms Getco LLC and Virtu LLC. The Wall Stree... Read more
Knight Capital Group Inc. (NYSE:KCG) has agreed to sell itself to Getco, as we reported earlier this evening. For the past several weeks, there had been a large bidding war betwen Vurtu and... Read more
Knight Capital Group Inc. (NYSE:KCG) is being bought out by Getco, according to a report from both Reuters and Bloomberg. Stephanie Ruhle, of Bloomberg MarketMakers has some of the latest i... Read more


text:
Lacrosse: Jensen Beach girls top St. Thomas Aquinas in OT
Falcons top St. Thomas Aquinas 10-9
Hope Cotten scored five goals Thursday as Jensen Beach High School's girls lacrosse team defeated St. Thomas Aquinas 10-9 in overtime at Jensen Beach.
Kai Mildenberger added one goal and three assists for Jensen Beach (9-5).
Aley Mark scored two goals. Jenny Kilbride and Kelly Hagen added one goal apiece.
Annie Flanagan had seven saves and two interceptions.
St. Thomas Aquinas is 11-4.
Jensen Beach plays at St. Edward's at 4 p.m. Friday.
South Fork 18, Holy Trinity Episcopal 1: Sabrina Fernandez had two goals and three assists as the Bulldogs won on senior night at Tropical Farms.
Lindsey Barrett, Chloe Taylor and Courtney Buonocore had two goals and one assist apiece for South Fork (10-7), which honored five seniors and clinched a winning season.
Lauren Burnett had two goals and Samantha Arbour, Tabitha Storey, Kaley Safdir and Hannah Blum had one goal and one assist apiece.
Devon Becker, Elle Terranova, Haley Claunch and Abbie Horchar scored one goal apiece.
Jessica Bright had one assist and Kate Weiksnar made seven saves.
Taylor added 12 ground balls and Arbour had five ground balls.
Holy Trinity is 1-9.
District playoffs begin next week.
John Carroll Catholic 15, Melbourne Central Catholic 5: Clare Santangelo had three goals, three draw controls and two assists as the Golden Rams won on senior night in Fort Pierce.
Jenny DeNorio added three goals and one assist for John Carroll (5-6), which honored nine seniors.
Savannah Northup scored three goals.
Meaghan Sherer had two goals and one assist, Connie Madden had one goal and two assists, and Rebecca Alcindor had one goal and one assist.
Emily Whitty and Kim Caudell scored one goal apiece.
Whitty and Amanda Ortiz combined for eight saves.
Melbourne Central Catholic is 2-6.
Martin County 14, Park Vista 5: Hunter Jones had five goals and one assist as the Tigers won in Stuart.
Luke Kendall added three goals and three assists for Martin County (8-6). Owen Anderson had two goals and two assists, Scott Beck had two goals and one assist, and Anthony Pellegrino had one goal and one assist.
Joey Estevez had one goal. Troy Fischer and Anthony Senior added assists.
Eric Simon made 10 saves.
Jones and Pellegrino had six ground balls apiece. Beck, Nick Yanora and Andrew Mauer added five ground balls.
Park Vista is 5-9.
Martin County plays at Benjamin at 7 p.m. Friday.
Boca Raton 11, Jensen Beach 10: Jared Welsh had two goals and three assists in the Falcons' loss at Boca Raton.
Beau Ladwig and Ryan Gallaher scored two goals apiece for Jensen Beach (8-6).
Kyle Van Wagner had one goal and three assists. Cameron Wadsworth, Hunter East and Clayton Deutschmann scored one goal apiece.
Austin Brodie made nine saves and Wyatt Weiseman won 15 of 23 faceoffs.
Boca Raton is 13-3.
Jupiter Christian 14, Pine School 6: Kyle Tuttle scored seven goals and assisted on another as the Eagles (2-11) won in Hobe Sound.
Pine School (2-9) lost its eighth consecutive game.
All Saints' Academy 13, Sebastian River 8: The Saints (6-8) handed the Sharks (2-10) their sixth consecutive loss at Winter Haven.
Palm Beach Gardens 13, South Fork 6: The Gators (10-4) defeated the Bulldogs (8-6) in Palm Beach Gardens.
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text:
Kidney cancer is one of the top 10 most common cancers in both men and women. According to the American Cancer Society, more than 61,500 people in the United States will learn they have kidney cancer this year, and about 14,000 Americans will die from it. What do you know about this significant disease?
While the only way to know for sure if you have kidney disease is to get tested, there are a number of physical signs. Sometimes people attribute these physical symptoms of kidney disease to other conditions. This is because those with kidney disease tend not to experience symptoms until the very late stages, when the kidneys are failing or when there are large amounts of protein in the urine.
Chronic illness takes many things, but it teaches many things too. I have learned that life should be lived urgently, acceptance is vital to spiritual connection, and that I am more than my body. Power was found in the most unexpected place. Sometimes it takes a thief to show us just how resilient we are.


text:
Man Who Got Carter, The
Michael Klinger, Independent Production and the British Film Industry, 1960-1980
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moreMichael Klinger was the most successful independent producer in the British film industry over a twenty year period, from 1960 to 1980, responsible for 32 films, including classics such as Repulsion and Get Carter. Despite working with many famous figures, including Michael Caine, Claude Chabrol, Mike Hodges, Lee Marvin and Roman Polanski, Klinger's contribution to British cinema has been ignored.This definitive book on Klinger, largely based on his previously unseen personal papers, examines his origins in the Sixties' Soho sex industry, sexploitation cinema and 'shockumentaries', through to major international productions, including Shout at the Devil. It reveals how Klinger deftly combined commercial product – the popular 'Confessions' series – with artistic, experimental cinema and highlights the importance of his Jewishness. The book also assesses the essential, often misunderstood role played by the producer. less
I.B.Tauris; October 2013
294 pages; ISBN 9780857723093
Read online, or download in secure PDF format
Title: Man Who Got Carter, The
Author: Andrew Spicer; A. T. McKenna; Mike Hodges
294 pages; ISBN 9780857723093
Read online, or download in secure PDF format
Title: Man Who Got Carter, The
Author: Andrew Spicer; A. T. McKenna; Mike Hodges
Buy, download and read Man Who Got Carter, The (eBook) by Andrew Spicer; A. T. McKenna; Mike Hodges today!
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American Sniper 2012 US$ 7.99 400 pages
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text: Edward Conery | IBDB: The official source for Broadway Information IBDB: The official source for Broadway Information Official Broadway League sites: - sites - broadway.org broadwayleague.com broadwayfanclub.com kidsnightonbroadway.com stagespecs.org tonyawards.com Quick Search For: In This Category: All Show People/Org. Theatre Season Edward Conery Performer Male Productions ProductionsDate of ProductionsPygmalion[Play, Comedy, Revival] Performer: Edward Conery [Bystander] Understudy: Edward Conery [Sarcastic Bystander, Alfred Doolittle]Apr 26, 1987 - Aug 02, 1987Present Laughter[Play, Comedy, Revival] Performer: Edward Conery [Morris Dixon]Jul 15, 1982 - Jan 02, 1983The Little Prince and the Aviator[Musical, Original] Performer: Edward Conery [Businessman] Understudy: Edward Conery [Toni, Georges]Never Officially Opened - Jan 17, 1982 Find out where Edward Conery and are credited together © 2001-2015, The Broadway League, All Rights Reserved. (Copyright and Disclaimer)


text:
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study will evaluate the safety and effectiveness of simvastatin in treating children with Smith-Lemli-Opitz syndrome (SLOS). Patients with this inherited disease are deficient in an enzyme that converts a substance called 7-dehydrocholesterol (7-DHC) to cholesterol. Cholesterol synthesis is impaired, causing birth defects and mental retardation. This study will examine whether simvastatin can increase the amount of the deficient enzyme, thereby lowering 7-DHC and increasing cholesterol. It will examine the safety of simvastatin in affected children and its effects on their behavioral problems.
Children between 4 and 18 years of age with mild to typical SLOS may be eligible for this study. Participants will be evaluated at the NIH Clinical Center in Bethesda, MD, and at the Kennedy Krieger Institute in Baltimore, MD, upon admission to the study and again at 6, 12, 20, and 26 months. The visits will last 3 to 4 days, and will include a medical history and physical examination, photographs to document medical findings, and other procedures detailed below. In addition, blood samples will be collected at 1, 3, 9, 14, 15, 17, and 23 months. Parents will complete several questionnaires during the study. Procedures include the following:
- Simvastatin and cholesterol supplementation therapy. Patients take cholesterol supplements (50 milligrams per kilogram per day) plus simvastatin (0.5 mg/kg/day for 6 weeks and then 1 mg/kg/day) for 12 months, and cholesterol supplements plus a placebo for 12 months.
- Blood draws to check liver, muscle, and kidney function, hormone levels, vitamin D levels, blood counts, cholesterol and 7-DHC levels, and lipoprotein levels. Some extra blood is drawn for research purposes.
- Urine collection. Urine is collected using a toilet hat. For children who are not toilet trained, urine is collected in a bag taped to the skin with an adhesive.
- Electroretinogram (ERG) to measure the function of the retina, the light-sensitive tissue at the back of the eye. ERG is done under sedation. After adapting the child's eyes to the dark, an electrode is taped to the child's forehead, the surface of one eye is numbed with eye drops, and a contact lens is placed on the eye. The child looks inside a globe that emits a series of light flashes. The contact lens senses electrical signals generated by the retina when the light flashes. After the ERG, the patient has a full eye exam, including pupil dilation and photographs of the eye.
- Lumbar puncture (spinal tap) to collect a sample of cerebral spinal fluid (CSF). This procedure, done while the patient is sedated for the ERG, shows whether simvastatin affects brain cholesterol and chemical levels. Under local anesthetic, a needle is inserted in the space between the bones in the lower back where the CSF circulates below the spinal cord. A small amount of fluid is collected through the needle.
- CRH stimulation test to detect hormone-related problems in cholesterol synthesis. The patient is given CRH, a hormone involved in cholesterol synthesis, through a plastic tube placed in a vein. Blood samples are collected through the same catheter to measure levels of other hormones involved in cholesterol production.
- Electroencephalogram (EEG) to look at the electrical activity (brain waves) of the child's brain.
- Activity monitoring. An activity monitor, which looks like and is worn like a watch, is used to record the child's level of activity for a 48-hour period.
- Urine pregnancy test at every visit for female patients over age 10.
- Skin swab for sterol (solid alcohol, such as cholesterol) analysis. An alcohol pad is rubbed lightly against the child's arm or thigh to collect skin cells.
- Stool collection. A small stool sample is collected from the child's diaper or, for children who are toilet trained, from a toilet "hat" like that used to collect urine.
Smith-Lemli-Opitz Syndrome
Drug: Simvastatin Susp.
Drug: OraPlus
Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
|Official Title:
|Investigation of Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
- Serum Cholesterol to Total Sterol Ratio [ Time Frame: 1 year after therapy. ] [ Designated as safety issue: No ]Total serum cholesterol (mg/dL) divided by the sum of all sterols (cholesterol plus its precursors, 7-dehydrocholesterol - 7DHC, and 8-dehydrocholesterol- 8DHC - in mg/dL).
- Cerebral Spinal Fluid Dehydrocholesterol to Total Sterol Ratio [ Time Frame: 12 months ] [ Designated as safety issue: No ]Percent of 7-dehydrocholesterol + 8-dehydrocholesterol as a fraction of the total sterols (cholesterol + 7-dehydrocholesterol + 8-dehydrocholesterol measured in cerebral spinal fluid
|Study Start Date:
|July 2003
|Study Completion Date:
|December 2010
|Primary Completion Date:
|December 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Placebo Comparator: OraPlus
Drug: OraPlus
During this trial and for two months prior, patients will be maintained on 150 mg/kg/day of dietary cholesterol (150 mg/ml in OraPlus) for the duration of the trial
|Active Comparator: Simvastatin Susp
Drug: Simvastatin Susp.
During the simvastatin phase of the trial, therapy will be initiated at 0.5 mg/kg/day for six weeks and then increased to 1.0 mg/kg/day if adverse side effects are minimal or absent.
Detailed Description:
Smith-Lemli-Opitz syndrome (SLOS, RSH, OMIM #270400) is an autosomal recessive, multiple malformation, mental retardation syndrome due to an inborn error of cholesterol biosynthesis. Specifically, these patients have a deficiency of 3 beta-hydroxysterol Delta 7-reductase activity due to mutation of the 3 beta-hydroxysterol delta 7-reductase gene (DHCR7). This enzymatic deficiency impairs the conversion of 7-dehydrocholesterol (7-DHC) to cholesterol in the last step of cholesterol biosynthesis via the Kandutch-Russel biosynthetic pathway. The clinical manifestations of SLOS are extremely variable and the phenotypic spectrum is broad. At the severe end of the spectrum SLOS is a lethal disorder with multiple major congenital anomalies, and in mild cases SLOS combines minor physical stigmata with behavioral and learning disabilities. Based on clinical studies, the incidence of SLOS is on the order of 1/10,000 to 1/60,000. Molecular studies have shown a carrier frequency of about 1% for the most common SLOS mutant allele in North American populations. Currently therapy is based on dietary cholesterol supplementation. Although clinical improvement has been noted, serum cholesterol levels are rarely normalized and elevated serum 7-DHC levels persist. Because elevated 7-DHC levels may have toxic effects, treatment of SLOS patients with an HMG-CoA reductase inhibitor has been proposed. Two small (two-patient) open trials of simvastatin therapy in SLOS have been reported. One of these trials showed improved clinical status, decreased 7-DHC levels and increased cholesterol levels. The second trial showed decreased 7-DHC levels; however, treatment had to be discontinued in one patient with preexisting liver disease. The goal of this clinical research protocol will be to test the clinical efficacy and safety of simvastatin therapy in mild to classical SLOS patients using a double blinded, crossover design.
|Ages Eligible for Study:
|4 Years to 18 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
All patients with biochemically proven SLOS will be considered for this study.
Patients will be excluded if they cannot travel to the NIH because of their medical condition.
Age less than 4 and older than 18.
Weight less than 10 kg.
Developmental delay too severe to obtain adequate behavioral evaluation.
Severe behavioral problems that preclude proper physical and laboratory medicine evaluation.
SLOS severity score greater than 30.
No biochemical diagnosis of SLOS.
No molecular conformation of SLOS.
Residual fibroblasts enzymatic activity less than 10% of control value (cholesterol synthesis as a fraction of total sterol synthesis).
Dehydrocholesterol/cholesterol ratio greater than 1.0.
Renal insufficiency.
Contraindications for simvastatin use:
History of hypersensitivity to simvastatin or other "statins."
Acute liver disease.
Persistent elevations of serum transaminase levels or persistent elevations of CPK.
Concomitant therapy with tetralol-class calcium channel blockers (such as mibefradil).
Pregnancy or lactation.
History of rhabdomyolysis or myopathy.
Concomitant therapy with other drugs associated with myopathy (such as gemfibrozil or other fibrates, niacin) or metabolism by the P450 isoform 3A4 system (such as cyclosporin, itraconazole, ketoconazole, macrolide antibiotics, or nefazodone (Serzone)).
Warfarin-type anticoagulant therapy.
Severe cataracts.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00064792
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Forbes D Porter, M.D.
|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Additional Information:
|Responsible Party:
|Forbes Porter, M.D., Clinical Director, NICHD, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|ClinicalTrials.gov Identifier:
|NCT00064792 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 11, 2003
|Results First Received:
|July 30, 2012
|Last Updated:
|June 4, 2014
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by National Institutes of Health Clinical Center (CC):
HMG-COA Reductase Inhibitor
Malformation Syndrome
Mental Retardation
Smith-Lemli-Opitz Syndrome
Additional relevant MeSH terms:
Cleft Palate
Genetic Diseases, X-Linked
Smith-Lemli-Opitz Syndrome
Abnormalities, Multiple
Bone Diseases
Bone Diseases, Developmental
Congenital Abnormalities
Craniofacial Abnormalities
Craniofacial Dysostosis
Genetic Diseases, Inborn
Genital Diseases, Male
Jaw Abnormalities
Jaw Diseases
Lipid Metabolism Disorders
Lipid Metabolism, Inborn Errors
Maxillofacial Abnormalities
Metabolic Diseases
Metabolism, Inborn Errors
Mouth Abnormalities
Mouth Diseases
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Pathologic Processes
Penile Diseases
ClinicalTrials.gov processed this record on October 09, 2015


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I thought that Tony Blair had lost the ability to shock me. But within a few seconds of picking up his newly published memoirs today, I realised I was mistaken.
I'm delighted to hear that the activist comedian Mark Thomas has agreed to speak at the National Gathering of the Campaign Against Arms Trade (CAAT), which will take place in London on 6 November.


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An interview with Fargo star Allison Tolman
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IRVINE, Calif., June 8 /PRNewswire-FirstCall/ -- ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA), today announced positive results from a proof-of-concept Phase 2 clinical study in subjects with dry eye disease (keratoconjuctivitis sicca) using a new, proprietary, low-dose formulation of bromfenac, the active ingredient in Xibrom(R) (bromfenac ophthalmic solution) 0.09%. The study achieved statistical significance in the primary endpoint of the objective sign of conjunctival staining (Lissamine Green test) as compared to baseline. The study also achieved statistical significance on the objective sign of corneal staining (Fluorescein test) as compared to baseline. Patients also achieved statistically significant improvements in subjective symptoms measured by the Ocular Surface Disease Index (OSDI) and improvement in patients' most bothersome ocular symptoms.
"The strong clinical results from this proof-of-concept study further support our belief that a modified, low-dose formulation of bromfenac has the potential ability to effectively and conveniently treat signs and symptoms of dry eye disease and provide fast and sustainable relief for patients. Bromfenac's strong safety profile should support long-term treatment, which would be necessitated due to the chronic inflammatory nature of dry eye disease," stated Vicente Anido, Jr., Ph.D., President and Chief Executive Officer of ISTA Pharmaceuticals.
"ISTA is strongly committed to focusing on dry eye disease. The results of this study may help identify patients that would be most suitable for a larger, placebo-controlled study. These data come on the heels of our recently announced positive ecabet sodium Phase 2b study results in ISTA's dry eye franchise. We will analyze the data from both programs to determine which product candidate or candidates to move into further advanced stud
|SOURCE ISTA Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved


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Lebanon Today
Nizar Abdel-Kader is currently a political analyst and columnist at Ad-Diyar Newspaper, Beirut. He is the author of two books Iran and the Nuclear Bomb and A Nation of No Fences, in addition to many published research papers on current political, strategic, and security topics. He lectures on security and international relations and Middle Eastern issues at many international forum and has been a lecturer at the Lebanese University the College of Economics and Business Administration. He is a member of the board of the National Defense Journal (Lebanon).
Nizar was a career military officer for 39 years with the Lebanese Armed Forces, retiring in 1995 with the rank of Major General.
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January 12-17 | Tickets On Sale Now!
Holding It Down: The Veterans' Dreams Project
Dare to Go Beyond
A series as eclectic as it is refined, ASU Gammage's BEYOND Series is like no other in the country. This carefully curated performing art series brings world-class artists into our community. These artists immerse themselves by not only presenting evocative and compelling work, but also by connecting to our Valley residents through engaging Cultural Participation programs.
Support the Plan for Additional Restrooms and Elevators
One of the Golden Gammage Initiative's most exciting projects is entitled Elevate & Alleviate. This plan calls for additional Women's Restrooms and Elevators that will increase the accessibility of the venue by adding elevators allowing access to all levels. The long lines at the women's restrooms have been one of the most frequent issues that patrons experience at ASU Gammage. "I've always thought the longest lines at ASU Gammage should be reserved for the actors on stage and not for our patrons trying to use the restroom. Now with the support of our patrons that will soon be the case," says Peter Means, Senior Director of Development at ASU Gammage.
The quintessential backstage musical comedy classic, 42nd Street is the song and dance fable of Broadway with an American Dream story and includes some of the greatest songs ever written, such as "We're In The Money," "Lullaby of Broadway," "Shuffle Off To Buffalo," "Dames," "I Only Have Eyes For You" and of course "42nd Street."


text: I am in a frustrating rut myself. Summer means high sun most of the day. I have new puppy that needs A LOT of time. Too much work. Too many family obligations. Not making any progress in putting the darkroom together. I have definitely grown crabbier as my time behind the lens has diminished.


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Discouraged and offended
The hospital staff and Auxiliary members are both discouraged and offended to find that someone in our community has taken decorative items that were placed in the hospital entry. Those items were put in there to send a friendly and welcoming feeling to the residents visiting the facility. The Auxiliary members work together raising money to assist our community hospital in any way they can. Unfortunately, we are forced to discontinue this project, as it becomes expensive to replace the items that have been taken.
Rita Clark
Lobby Decorations Chairman
Appreciation is a wonderful thing
I just wanted to take a moment and thank everyone for supporting the recent Youth of the Year banquet held at the Boys & Girls Clubs of Mason Valley. The event was a sold out, and our keynote speaker was Daniel (Rudy) Ruetigger, whose true story was depicted in the movie "Rudy." The event was a smashing success, and we heard from some amazing youths who truly had their own "Rudy" stories.
The event was fully catered by our friends at the Hey Day Inn in Wellington. Chef Bill and his amazing crew of staff and with Boys & Girls Club professionals did an amazing job with service. The food was exactly what you would expect from the Hey Day, - fantastic.
We would also like to thank and recognize the judges for the much anticipated Youth of the Year event - Lyon County School Superintendent Keith Savage, Silver Springs Elementary School Principal Jim Gianotti, Lyon County Commissioner Bob Hastings, Lyon County Clerk/Treasurer Nikki Bryan, and Lyon County Sheriff Allen Veil. These judges had the difficult task of having to choose from six amazing teenagers one to represent our organization as our 2013 Youth of the Year.
The Boys & Girls Clubs of Mason Valley awards the Youth of the Year a $1,000 scholarship, and the youth moves on to the state-wide competition, which takes place March 11-12 at the Governor's Mansion in Carson City. The winner of the state completion also wins more scholarship money and moves on to the regional competition, where that winner represents the entire Pacific Region and gets to go to Washington, D.C., and compete nationally, and meet the President of the United States, too.
I would like to also thank my amazing staff, which truly did a tremendous job organizing and preparing for what was an amazing night. We are very blessed to have so many dedicated individuals who truly do care about the youths in our communities. Currently, our organization has six sites covering Dayton, Silver Springs and Yerington serving over 1,200 youth annually with a combined daily attendance of over 300.
In order to serve all the youths countywide, we rely heavily on our amazing partnership with the Lyon County School District, its Board of Trustees and local school faculties, who consistently support their youth and our efforts.
I would also be remiss if I did not recognize the amazing leadership and support from our Board of Directors, led by Executive Board President Justin Aguilar, Vice President Shaline Montgomery, Treasurer Michael Roberson and Secretary and Founding Board Member Pamela Peri. They are joined by an amazing group of very passionate and dedicated board members like Kathy Dini, Tim Dyhr, Jeff Page, and Ross Whitacre.
On a personal note, I would like to close by thanking my family, especially my wife Lori ,who puts up with me and my constant ramblings on my favorite subject: The Boys & Girls Clubs of Mason Valley!
Thank you all for the support and know that on behalf of everyone associated with our organization, we truly thank each and every one of you!
Travis Crowder
Chief Professional Officer
Boys and Girls Clubs of Mason Valley


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During one of the many recent Republican debates Mitt Romney offered to bet Rick Perry $10,000 that he didn't edit text in a new addition of his book. This a perfect example of how out of touch he is with the average American.
Prints & more available at Society6! / Daily Drawing #1026.


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: : Blog
Looking At The Rest Of The Field In Jupiter
Perfect Game Staff
Monday, October 23, 2006
The other 50 teams
Looking at the rosters there are a few other teams that have the ability to finish high in this years WWBA Championship.
Of course, the final rosters are not official until the teams play their first game. Some teams will be adding several key players, while others could lose a player or two.
Anyway, Here is a short report on those teams not listed as one of the top 30 in the Handicapping article on the home page..
Baseball Northwest
?€? The roster includes many from the state of Washington and shows top national level prospects like 3B Travis Mattair, and pitchers Julian Sampson and Keaton Hayenga. Several other top 07 grads along with a couple talented 08s make this a team to watch. Probably should have been in the top 30 easily.
Cangelosi Orioles
?€? The ex Big Leaguer John Cangelosi has some of the top prospects from Illinois. LHP Casey Crosby, OF Mike Kaczmarek, RHP Kyle Kaminski and C Ian Tomkins are 4 to watch closely and there are more! This team has a chance to go a long ways into the tournament.
Tri State Arsenal
?€? This probably should have been a team listed in the top 30 in the WWBA Handicap article. Chris Berroa is an 07 to watch and Quinton Miller is an 08 pitcher everyone needs to see! The rest of the roster is well stocked with DI and/or pro prospects.
Dallas Tigers
?€? One year they finished 2nd in this tournament. One player we are interested in seeing again is RHP Brian Shore, but there are several other talented 07s and 08s on this roster.
?€? This team always competes in WWBA events. A big roster full of good prospects including lefty Craig Gullickson (son of Bill) who was the most valuable pitcher at the WWBA Summer Championship.
Atlanta Blue Jays
?€? A mixture of top 07s and top 08s make this team very competitive at any level. Rico Reid is a hard throwing 07 RHP to watch. MIF Tim Beckham is ranked among the top 08s in the country. There are many other high level prospects on this tea.
Team British Columbia
?€? For the first time we get to see a team with some of the top talent from Western Canada at the WWBA Championship.
East Cobb Cardinals
?€? Highly ranked players like MIF Brian Fletcher, C Chris Kay, 3B Clay Remole and some top ranked 08s make this a team to watch.
Team California
?€? A lot of talent that we haven?€™t seen yet. Looking forward to watching this team.
Bill Hood
?€? The Louisiana power program always has a lot of talent. We?€™re looking forward to seeing some talented prospects for the first time.
Austin Baseball Club
?€? This group of Texas players includes the talented Ross Speed and plenty of other outstanding players.
Team Connecticut
?€? They?€™re loaded with top 07s and top underclassmen. They could make a strong run
OTC Bearcats
?€? A lot of high level talent and outstanding athletes here. Isaiah Fronberger is a player to watch. And he?€™s not the only one!
Central Florida Renegades
?€? Lots of talent and always a threat to get deep into the tournament.
Puerto Rico Raiders
?€? A perennial outstanding program from PR, there will be some big surprises here.
McHenry County
?€? This Illinois based team features top prospect Jake Smolinski among a talented line up.
On Deck O?€™s
?€? This North Carolina team always compete well against the very best. A team that?€™s always full of DI prospects.
Mid Atlantic All Stars
?€? Always a few big surprises every year out of this team.
Florida Magic
?€? They finished runnerup in the WWBA 17&u National. A very strong team with good pitching and 17&U MVP Gary Gustavson.
Bellaire Cards
?€? Relly Mercurio and Matt West are just two very talented players on this Texas team.
Boomtown Prospects
?€? This Oklahoma based team can really compete. They put on quite a run in last years championship. Look for some big surprises.
Colorado Slammers
?€? There?€™s a few prospects we can?€™t wait to see on this roster.
Champions Baseball
?€? This will be the hometown favorite. They are young but very talented and coached by ex Big Leaguer Robby Thompson.
College Select
?€? This team from the Northeast always competes. They have a lot of good pitching.
West Coast MVP
?€? A lot of California talent here. Some will be very well known at the conclusion of this tournament.
Winning Inning
- Don?€™t be surprised if this group of talented players makes a run at things.
?€? There bringing a young team from Texas. There should be a lot of talent, but most of it is not eligible for the draft. I guess the 300+ Major League scouts including MLB Scouting Directors will be somewhat disappointed. College coaches might be very interested though.
Team Puerto Rico
?€? Another big roster of talent from Puerto Rico
Central Florida Black Racers
?€? We don?€™t know a lot about them, but they are young and they won the Florida Regional, so there has to be some serious talent here.
Tidewater White Sox
?€? Lots of talent including a couple of 07s who have been ranked in the top 100.
Florida Pokers
?€? Another long time program with a lot of talent.
Iowa Select Team
?€? Some very good talent including a couple of the top 08s in America.
St Louis Pirates
?€? Some very good talent from the St Louis area.
The PG Teams
?€? A group of talented players from mostly the Northeast. Coached by Bob Parks.
?€? Players from all over the East, watch for talented Cooper Sniatynski. Coached by Gaby Sanchez.
Columbia Blue
?€? Players from all over. OF Chris Duncan is just one that needs to be followed. Coached by Mike Duncan.
Dark Green
?€? From the East Coast, top to bottom. They will be interesting. Coached by Rick Pavy.
?€? This group could pull off some big upsets. There is talent here!
Kelly Green
- This team could surprise. Loaded with top underclassmen. Coached by Frank Montalvo.
?€? Mostly from NY, we look forward to watching this team. Coached by Edwin Ortiz.
?€? There is some serious high level talent on this PG Team. All from New Jersey! Coached by Keith Dilgard.
?€? Mostly from the south, lots of talent. Coached by Brad Tremitiere
?€? This PG Team could surprise a lot of people. A very talented group. Coached by PG favorite Jimmy Zellman.
?€? Lots of talent from Northern Florida. There are some big prospects, all classes, on this roster. Coached by Roger Maris?€™ son Kevin.
?€? South Florida and one Indiana player coached by Ralph Suarez, they should compete.
?€? Players from all over and some serious talent. Coached by Derek Barrows.
?€? Very talented group that will compete with most everyone in the tourney. Coached by Chris Valdez.
PG Crosschecker
?€? See Handicap article, they are one of the favorites to compete for the rings. The Dominicans are suppose to be very talented. This team has a few top prospects that not many know about yet. That?€™s about to change. Team coached by Red Sox scout Ray Fagnet.
The top 30 Handicap article can be viewed here.
All rosters can be viewed at
Keep in mind that many of these rosters are yet to be completed. Look for several top national prospects to show up on these rosters by next week.
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text:
Pao Chao Hsieh was born in Canton, China, February 15, 1896. In 1912 he entered Tsing Him College, Peking, and graduated from that institution 1919. He was appointed to a scholarship to enable him to complete his education in an American college. He entered the College of Arts and Sciences of the Johns Hopkins University in October, 1919, and received the degree of Bachelor of Arts in June, 1920. In the fall of that year he began his graduate studies in the Departments of Political Science, Political Economy and History.
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Publication information: Book title: The Government of China (1644-1911). Contributors: Pao Chao Hsieh - Author. Publisher: Johns Hopkins Press. Place of publication: Baltimore, MD. Publication year: 1925. Page number: *.
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Table of contents
- Title Page *
- Preface *
- Contents *
- Chapter I - Theoretical Basis of the Government 1
- Chapter II - The Emperor 24
- Chapter III - The Nobles and the Privileged Classes 45
- Chapter IV - Important Organizations in the Central Government 68
- Chapter V - The Department of Civil Service (Li Pu) and Civil Service Laws 99
- Chapter VI - The Department of Rites, (Li Pu) and Civil Service Examinations 140
- Chapter VII - The Department of Revenues: Finance and Taxation 185
- Chapter VIII - The Judiciary 215
- Chapter IX - The Foreign Office 235
- Chapter X - Other Services in the Central Government 255
- Chapter XI - Provincial Government 289
- Chapter XII - Territorial Government 321
- Chapter XIII - Changes after 1898 343
- Chapter XIV - Policies of the Government: Conclusion 376
- Bibliography 409
- Vita *
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Leave a Review
The baklava is NOT supposed to be crunchy. The version that you buy in supermarkets is dried out old baklava, that's why it's crunchy. I grew up around people making baklava from scratch, and women boasted about the baklava being soft (not mushy though). For this, the syrup should not be too thin (turning the baklava to mush) or too thick (and not absorbed, making the baklava crunchy). Agree, more cloves needed. Also, no need to add filling in separate layers - one layer of filling (or 2 at most) does it for me and is easiest.flag if inappropriate
Needs more clove and cinnamon. Also, try with just honey. Syrup sucks. Too wet. Baklava lost it's crunch. This recipe makes 2 layers of nuts. Try using 24 oz instead for 3 layers. Baked at 350 for a longer time. Took a while to brown. I would not make this recipe again without the above modifications.flag if inappropriate
Made 4 pans today for X'mas treats. I added double the cinnamon and 1/4 tsp. extra of cardamom to both the filling and syrup. I added all the syrup in one pan and it was a bit soggy for my taste. The next pans I added 1/2 the syrup and preferred that amount. I didn't lower the temperature just baked for about 40 minutes at 350. Mmmm good.flag if inappropriate
I've used this recipe several times and it always is great. My granddaughters are coming over tomorrow and they want to learn how to make baklava. this will work great.flag if inappropriate
Relatively easy to make and I got rave reviews from everyone. The pastry is the only tricky part.flag if inappropriate
This was the stickiest baklava I've ever been near in any country, but the flavor was excellent!flag if inappropriate
This was my first time using phyllo dough. This was the best baklava we have ever tasted! I used mostly pistachios and rose water to flavor it. A bit of work but delicious. Tastes even better the 2nd and 3rd days.flag if inappropriate
This was delicious!! I've never made baklava before and I was a little concerned about how difficult it would be, but it wasn't at all! Although, it was much, much more time consuming than I thought it would be. Even so, I would still take the time to butter each individual layer. I used blanched, slivered almonds in my recipe more because of what the introduction said they meant than anything. None of my friends that tried it had ever had it with almonds, but we all agreed it was really delicious! My Armenian friend also strongly approved, despite being used to the Paklava version! :)flag if inappropriate
This was awesome! My husband is Jewish, from Israel and this was a taste of home for him. It was easy and tasty!flag if inappropriate
I love baklava and I love this recipe. Tastes as good as or better than the many I've had in middle eastern restaurants. I made it with the honey, 3 cloves and the recommended amt. of cardamom and otherwise basically stuck to the recipe (used a few more phyllo sheets). I also used the corn syrup - not sure if that was necessary or not. Will definitely make it again - but only when there's enough people to share b/c it's SO addictive.flag if inappropriate


text:
UPTON, NY New details of the composition and structure of a needlelike protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection. The research, conducted in part at the U.S. Department of Energy's Brookhaven National Laboratory, will be published April 26, 2009, in the advance online edition of Nature Structural & Molecular Biology.
The scientists were studying a needlelike protein complex known as a "type III secretion system," or T3SS, on the surface of Shigella bacteria, a cause of dysentery. The secretion system is a complex protein structure that traverses the bacterial cell membrane and acts as a biological syringe to inject deadly proteins into intestinal cells. These proteins rupture the cell's innards, leading to bloody diarrhea and sometimes death. Similar secretion systems exist in a range of other infectious bacteria, including those that cause typhoid fever, some types of food poisoning, and plague.
"Understanding the 3D structure of these secretion proteins is important for the design of new broad-spectrum strategies to combat bacterial infections," said study co-author Joseph Wall, a biophysicist at Brookhaven Lab.
Previous studies of the type III secretion system have revealed that it is composed of some 25 different kinds of proteins assembled into three major parts: a "bulb" that lies within the bacterial cell, a region spanning the inner and outer bacterial membranes, and a hollow, largely extracellular "needle." But to understand how the parts work together to secrete proteins, the scientists required higher-resolution structural information, and knowledge of the chemical makeup and arrangement of the components.
Using a combination of scanning transmission electron microscopy (STEM) and transmission electron microscopy (TEM), the scientists have now revealed new details of the "needle complex" structure.
"STEM and the other technique
|Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory


text:
10 posts tagged with cats by schroedinger.
Displaying 1 through 10 of 10.
The poop is definitely in the box (er, raised bed), how do I get it out
What do I do about the cat poop in my raised beds if I don't want to get rid of the cats? I have a little feral/community cat colony in my (urban) backyard. They have chosen two of my raised beds as their toilet. Now that the snow has melted the smell is kicking in. I don't want to drive the cats away, but I would like my backyard to not smell of sewage and maybe even use those beds for non-edibles. Anyone have ideas? [more inside]
Help me find the perfect cat bed
I got my cats this bed and this bed recently. I would like to find a combination of the two for the Ultimate Cat Bed--something with the small opening of the first combined with the wide opening of the second. Any recommendations? [more inside]
Cats having GI problems, vets are not helping
Cats suffering from blood in poop, diarrhea, vomiting for the past month. Vets keep telling me there's nothing wrong, all of their treatment suggestions haven't worked. Can't keep spending money on vets, please advise. Cat poop discussion inside! [more inside]
What should I do with this stray cat family?
What do I do about this stray cat family with kittens? I would be OK doing TNR, but I don't want to return them to my backyard because my neighbors catch strays and kittens and kill them. I've reached out to local groups for help but they have no room and won't lend me traps because I don't want to return the cats to the same location. [more inside]
The Perfect Cat Tree (refusing to use the pun on "purr")
Cat trees: I've never owned one but have been offered one as a present for my pretties. What should I keep in mind? Do you have any recommendations? I'm thinking about this one. I would attach "cat stairs" to the walls but I'm not allowed, so a cat tree it is. I don't want to end up buying a big tree that they're able to knock over in five minutes or is covered with nonsense they'll never touch. My cats are big climbers, they like cozy sleeping spots but height is a priority for the cat tree. Maybe I'm overthinking this? [more inside]
How do I get my cats to stop knocking things over?
How do I cat-proof a bookshelf and desk? My cats like to climb on my bookshelf and desk and knock things off of them, sometimes for fun and sometimes to get my attention. I would like them to stop doing this. [more inside]
Is this a cat emergency?
Yesterday or the day before I noticed one of my cats was squinting a little in one eye. Then she started producing thick yellow goop. This morning there was a lot more thick yellow goop. This evening I noticed the nictating membrane of that eye is a little pinker and more swollen than the other one. She is having no trouble breathing and her appetite, thirst, and energy are normal. I don't have a lot of money. How urgent is this situation? [more inside]
What is the best way to find a new home for adult cats?
You have a friend with two well-behaved adult cats. He does not want the two cats any more. You want to give them to the Best Home Humanly Possible (not a rescue organization, ideally) and so far can't find any friends or family who can take them in. You posted your Craigslist ad with the adorable picture of them grooming each other, and now what? [more inside]
Is my kitty sick or in need of a nose job?
Does my cat have a chronic respiratory infection, or is it possible she just naturally has poor breathing passages? Ever since my partner and I adopted her and her sister in August she has had periodic coughing and hacking fits that have been relatively unaffected by three separate rounds of antibiotics. Now I wonder if maybe she just has the equivalent of a deviated septum, or whether it's time for hospitalization. [more inside]
My cat is too freaked out to eat. What do I do?
My adopted cat is freaked out about her new home, and getting more freaked out with each passing day. Now I'm afraid she's so freaked out she's not even emerging to eat or drink. What do I do? [more inside]
Page: 1


text:
Devasom is a hotel located at the sea-side of Hua Hin. The main transportation in Hua Hin is taxi....
See full review
Devasom is a hotel located at the sea-side of Hua Hin. The main transportation in Hua Hin is taxi....
This small hotel has a good design but the service is not impress me.
See full review
This small hotel has a good design but the service is not impress me.
Customers who viewed Devasom Hua Hin Resort also booked these hotels.
Extra charges may apply for children. Incidental charges, such as room service, are not included in the quoted rate.
The amenities and/or facilities may not be located at the hotel, but within a reasonable distance, and additional charges may apply for use.
Overall score
Reviewer score
Would not recommend
Good design with fair services
This small hotel has a good design but the service is not impress me.
Would recommend
A Perfect Experience
Devasom is a hotel located at the sea-side of Hua Hin. The main transportation in Hua Hin is taxi. As this is not a famous big hotel, you better print a map and Thai address of the hotel so that the driver can take you to the hotel.
friend and I arrived at Hua Hin by train. We went to the night market for some food then we went back to the hotel. The driver found the way in a couple of minutes by looking at the map and asking other driver. The hotel was small but beautiful. The staff at the check-in was nice. She helped me to check in my room efficiently and bring me to the room. I had a room at the center of the building. The scenery was exactly the same with the one I had seen online. The room was big and comfortable. Tha bathroom was clean.
Tips: for taxi fee, I usually negotiate the offer by -20% and they usually accept the offer.
Huahin is a small town. I spent 4 days there. My staying experience was awesome. There were few amenities in the hotel, only a small swimming pool and a reading room. But for me, who seek a relaxing and retreating experience. I don't mind at all. Apart from the great guest rooms, I was also impressed by the design of the hotel. The design suits the surrounding, a building with only three levels, reserving a lot of space for grass, plants and trees. There is a staircase to the beach in front of the hotel. Don't expect you can swim there. But walking there is also enjoyable. The members of staff are attentive and willing to provide help. They helped me to make reservation in 2 massage centre in Bangkok, suggested some places for us to go around Hua Hin and arranged transport for me. There is a shuttle offered by the hotel to the clock tower, you may check the timetable and see if you can use their service.
I had a package with breakfast. The breakfast is simple and delicious. They offer made-to-order breakfast in weekdays and buffet in weekends. The choice is varied, with fruits, eggs, toasts and salads. They offer some music nights for guests as well. But I didn't attend it.
Overall, I recommend this hotel very much, especially for those who want a quiet retreat and relax holiday.
HotelClub is a registered trademark of HotelClub Pty Ltd.
HotelClub is owned and operated by HotelClub Pty Ltd., an affiliate of HotelClub Limited, part of Orbitz Worldwide Inc
**1 Member Reward = 1 USD, converted to USD today. See full Membership Terms and Conditions for details.


text:
|Product Image
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PHONE CARD Magic Trick
Picture this... You are just finishing up a phone call as you approach a couple at their table. You tell them that was the manager of the establishment and he asked you to entertain them...
|$10.00 $6.00
>> More Info
Sponge Balls - Set of 4 Super Soft
These are the "super soft" sponge balls manufactured by Magic by Gosh. They're softer and compress smaller than any sponge ball on the market and are very easy to palm. They simply can...
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Fingertip Utility by Vernet
When it comes to vanishing objects, exchanging them or making them appear nothing compares to the false fingertip by Vernet Magic. The fingertip can be used where a thumb tip can't and it will...
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Pinkie (little) Tip - Vernet
This is the smallest fake fingertip available, the little or pinkie fingertip by Vernet. Crafted from the same non-reflective flesh colored plastic as the other Vernet tips, this little devil fits...
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King Size (Goblin) Thumb Tip - Vernet
This Thumb Tip is about the same diameter as a regular thumb tip but it's significantly longer. 2 1/2" inches long to be exact. That means it can conceal a larger load, or multimple...
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Master Wax - Flesh Color
Is your wax letting you down? The Master Wax is Steve Fearson's preferred blend of flesh colored premium magician's wax specially formulated for thread work....
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Master Wax - Stealth Black
Steve Fearson's Master Wax now available in non-reflective STEALTH BLACK for hooking up in all the sneaky places black comes in handy! Also perfect for attaching invisibly to black playing...
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SHRINK - The Shrinking Cigarette
What a way to cut down on your smoking! Shrink is a pocket trick you'll want to take with you everywhere. You display a cigarette and a fancy metal cigarette holder with a gold cap. ...
>> More Info
Is it physics? Is it Chi Power? Or is it something more? Find out as Steve Fearson teaches you a secret technique he developed after a lifetime of searching for the ultimate way...
>> More Info
Amagazing - The Amazing Magazine Test
"Amagazing is SO strong, and the method so deviously simple, you'll feel like you're performing REAL magic! It really is the next best thing to having actual psychic powers!" ...
>> More Info
Devil Coin Vanish
I've got a new discovery to share with you.. There's been a video floating around the net that has all the best coin magicians scratching their heads. It's a video of a coin vanish...
>> More Info
Disc Magnets - Set of 4
These Neodymium Disc Magnets are 5/16" in diameter and 1/32" thick. The are super strong and useful for all sorts of applications. They are also exactly the same size as the magnets used...
>> More Info


text:
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25% Discount FOR Labor DAY WEEKPark your car upon arrival and walk to any and all amenities including grocery store, liquor store, minature golf and resturant/ice cream at the end of the block. Walk to 10 resturants(from American to Steakhouse to Seafood to Italian to Chinese to Sushi), worlds best donut store, bagle store, fish store, banks and various shopping stores.Beach front home - (means on the beach) - shorecottage - 60+ years old - off street parking for four cars, located in Ship Bottom, Long Beach Island, New Jersey with five bedrooms, large deck, tons of dunes and immediate beach/ocean access. Wireless internet access - free - to all tenants. Excellent dining, shopping and all vacation amenities only a walk away. Golf courses located 15 minutes and 35 minutes away. "Coastal Living" type house with furnishings to match. Master bedroom looks out over the ocean. No better way to sleep! Washer and Dryeras well as outside shower below main floor. Deck chairs, tables and gas grill complete the beach front experience. Come get away from it all on Long Beach Island. Please note this is a beach cottage,Visit this lustrous 18-mile long island that settles six miles at sea.Just a short drive from New York City and Philadelphia and only 45 minutes from Atlantic City, the island has played host to summer visitors for more than one hundred years.Since the mid-1800's the Barnegat Lighthouse,on the north end of the island, has offered a beautiful aerial view of the Barnegat Bay, with its busy inlet for fishing, sport and sail boats enhancing the nautical experience.The south end of the island is lined with Victorian guest houses and even a small, off-Broadway, theatre.This shore community, with its small-town flavor, is full of amusements and shopping for families. Fine dining establishments, local fish/seafood houses and even an active nightlife welcomes our guests.Airport: Atlantic CityDistance: 30 minutesEmail the OwnerVisit WebsiteCheck Availability
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text: More from SI Report: Dodgers release pitcher Freddy Garcia Report: Dodgers release pitcher Freddy Garcia Marshawn Lynch sports gold cleats for Super Bowl Marshawn Lynch sports gold cleats for Super Bowl Louisville vs. FIU: Game time, live stream, TV coverage Louisville vs. FIU: Game time, live stream, TV coverage Pittsburgh-area high school football player dies after... Pittsburgh-area high school football player dies after... Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Duke's Mike Krzyzewski plans to coach at least five more years by Scooby Axson Email Posted: Thu Mar. 27, 2014 Updated: Thu Jun. 12, 2014 Duke head coach Mike Krzyzewski will coach USA Basketball at the 2016 Olympics in Brazil. (Andy Lyons/Getty Images)Duke head coach Mike Krzyzewski plans to coach at the school for at least five more seasons.Krzyzewski has been at Duke for the past 34 years and holds the Division I men's basketball record with 983 wins. His teams have been to 11 Final Fours and won four national championships.This season, the Blue Devils were eliminated in the NCAA tournament's Round of 64 with a 78-71 loss to 14th-seeded Mercer."I'm looking forward to the next five years," Krzyzewski said, via the Charlotte Observer. "What do we do in the next five, not just what do we do next season. What are the decisions? The first thing is I look at me. I'm going to be here."This past year I had a few setbacks and I had an episode with health at the Wake game. I wanted to clear the air that I'm good. I'm going forward."Krzyzewski, 67, was hospitalized after a loss at Wake Forest on March 4 after feeling light-headed during the game.Kryzewski will continue to coach USA Basketball in the FIBA World Cup this summer and the 2016 Summer Olympics in Rio de Janeiro, Brazil. WINN: The Sweet Sixteen teams most likely to win the national championship Promoted Stories Comments


text:
Marshfields Zach Leggon was a part of the winning Team Wisconsin in the recent Americas Showcase Championship Series in Pittsburgh April 9-12 with 3 goals and 2 assists. Congratulations Zach.
Bantams take second at State. Way to go Blades!
Awesome! U14 Co-Op takes third at State!
U14 Team takes 3rd at State!
The U14 Co-Op team took third place at State, and the Bantams took second.
Way to go Blades!
MYHA congratulates our skaters.
Great Northern Conference, Tiger Girls Co-op
Kessa Schreiner - All Conference Honorable Mention - Foward
Morgan Larson - All Conference Second Team - Defense
Morgan Larson - All State Honorable Mention - Defense
Wisconsin Valley Conference, Tiger Boys
Haydon Roy-Peterson - All Conference Honorable Mention - Goalie
Zach Leggon - All Conference Honorable Mention - Forward
Zach Leggon - Senior Class Tourney - Forward
Jake Andreae - Senior Class Tourney - Forward
If you have a lead on a billboard sign for the rink, click on the sponsor tab above.
Click on the link to view how to use the AED at the rink. Who knows??? Someday you may be called on to save the life of another...
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Sgt. Joseph A. Jett truly received a hero's welcome Wednesday afternoon from students at West Texas Elementary School in Stinnett. Holding a sign made in his honor is Sgt. Jett's niece, six-year-old Alyssa Beagle. Sgt. Jett and his wife Liz have a three-year-old daughter Chloe, who holds on to her dad tightly. He has come home after service in Afghanistan.
The Hutchinson County Court has released its latest disposition report as of April 20, 2011.
The cases in the report are as follows:
•Skylar Denham – appeal failure to attend school,
final conviction (fine only)
•Amanda Michelle Fought, theft of property >=$20<$500 by check, case dismissed (restitution made)
•Katherine Nanette Landrum, disorderly conduct Class C, order suspending sentence
•Phillip Lee Mitchell, driving while intoxicated, county jail
•Amber Dawn Reeves, driving while intoxicated (2nd), order revoking probation
The Borger ISD board of trustees took time to honor a longtime board member who will be stepping off this May.
Gary Schneck was recognized for his service to the board. Schneck, who has served on the board for 15 years, was up for reelection in the upcoming May general election, but chose not to run for another term.
Robert Bradley is seeking another term of office as a BISD school member. Also seeking election to the school board are Scott Mills, Diedre Hood, and Les Sharp. The top two vote-getters will be elected to the board in the May general election.
With some abandoned boats moved from The Marina at Lake Meredith, workers out there are trying to figure out the best course of action for those boats.
With the low lake levels, the decision was made by the National Park Service late last year that the drop had resulted in lake levels that could no longer support marina services. The services that were provided at LMNRA were discontinued on Jan. 1, 2011.
Abandoned boats were moved to a parking lot and all docks and dock buildings will be demolished and recycled.
The Borger City Council has made decisions on two property demolitions that were appealed by local citizens.
The actions were taken during the regular meeting of the council, held Tuesday afternoon at Borger City Hall.
The first property in question was 821 Moody, owned by C.C. "Bud" Reynolds. He told the council that he planned to demolish the property and clear the lot on his own. However, he said he had some workers he plans to put to work on the demolition and didn't want to put them out of business.
It's almost time for the 2011 Hutchinson County Free Health Fair and committee preparations are well underway!
The H.C. Free Health Fair will be held at the Frank Phillips College Access & Innovation Center located at 901 Opal in Borger on Friday, May 13 from 8:30 a.m. to 2 p.m. Sponsors for the event are the Borger Chamber of Commerce, Frank Phillips College School of Nursing, Texas AgriLIFE Extension, and Golden Plains Community Hospital.
On Monday afternoon the Frank Phillips College Board of Regents appointed Dr. Jud Hicks as the college's President at its monthly meeting, making permanent the position Dr. Hicks has held on an interim basis since December.
Dr. Hicks has been with FPC since 2002 and is the second generation of the Hicks family to lead Frank Phillips College. His father Dr. Andy Hicks served as the college's president from 1981 to 1988.
He holds a B.B.A. in Accounting from WTAMU; an M.B.A. in Management from Wayland Baptist University; and an Ed.D. from Texas Tech University.
The Relay For Life for Hutchinson County is now just a few weeks away!
The 10th annual American Cancer Society Relay For Life of Hutchinson County will be held from 7 p.m. Friday, June 10, 2011, until 7 a.m. Saturday, June 11, at Huber Park in Borger.
According to RFL media chair Judy Allen, committee members and team members are busy making plans for the event. There will be a variety of booths set up by participating teams that will be selling food, drinks, and many other items. Other activities planned include raffles, games, contests, live entertainment, and much more.
There are more than 800 people in the Texas Panhandle Tri-State area who suffer from a disease called MS daily.
People with this wake up ever morning having to inspect their body to make sure everything is properly working.
They are forced to live with one of the most expensive decease that would cost close or well over $70,000 a person each year.
Lake Meredith National Recreation Area and Alibates Flint Quarries National Monument have officially posted a ban on smoking and campfires in the parks.
The restrictions were made effective Saturday and will remain in place until decided by the Superintendent.
Park officials feel that "the risk to public safety and structures within park boundaries and neighboring communities from a human-caused fire is great enough that these restrictions are necessary."
Restrictions that have been put in place are as follows: