text:
Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor
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This is a multicenter study evaluating the safety and tolerability of Toca 511 administered intravenously to patients with recurrent or progressive Grade III or Grade IV Gliomas who have elected to undergo surgical removal of their tumor. Subjects meeting all of the inclusion and none of the exclusion criteria will receive a portion of the total dose of Toca 511 administered as an intravenous, bolus injection, followed approximately 11 days later by the remainder of the dose injected into the walls of the resection cavity at the time of planned tumor resection. Approximately 6 weeks later, subjects will begin treatment with oral Toca FC taken every 8 hours for 7 days, and repeated every 4 weeks. All subjects enrolled in this study will be encouraged to participate in a continuation protocol that enables additional 5-FC administration and the collection of long-term safety and response data.
Glioblastoma Multiforme
Anaplastic Astrocytoma
Anaplastic Oligodendroglioma
Anaplastic Oligoastrocytoma
Biological: Toca 511
Phase 1
|Study Type:
|Study Design:
|Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG & Followed by Treatment With Extended-Release 5-FC
- Determine maximum feasible, safe, and tolerated dose of Toca 511 as measured by dose limiting toxicities. [ Time Frame: 32 weeks ] [ Designated as safety issue: Yes ]
- Measure Toca 511 deposition in tumor at the time of resection by QT-PCR [ Time Frame: At time of surgical resection ] [ Designated as safety issue: No ]
- Measure how long Toca 511 stays in blood after IV administration by serum QT-PCR [ Time Frame: 10 days ] [ Designated as safety issue: No ]
- Safety and tolerability of Toca FC given at various doses and schedules as measured by dose limiting toxicities. [ Time Frame: 32 weeks ] [ Designated as safety issue: Yes ]
- Evaluate preliminary efficacy of Toca 511 and Toca FC by assessing overall survival, and tumor response rates. [ Time Frame: Ongoing ] [ Designated as safety issue: No ]
|Estimated Enrollment:
|Study Start Date:
|October 2013
|Estimated Study Completion Date:
|March 2016
|Estimated Primary Completion Date:
|October 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Toca 511 vector
Toca 511 a retroviral replicating vector expressing the cytosine deaminase enzyme
Biological: Toca 511
All subjects will receive Toca 511, a retroviral replicating vector that expresses the cytosine deaminase (CD) gene, intravenously and then intracranially. CD converts the antibiotic 5-fluorocytosine (5-FC) to the anti-cancer drug 5-fluorouracil (5-FU) in cells that have been infected by the Toca 511 vector. Beginning approximately 6 weeks after second administration of Toca 511, subjects will take a 7-day course of oral 5-FC. These 7-day courses of 5-FC are repeated every 4 weeks for the duration of the study.
Other Names:
|Ages Eligible for Study:
|18 Years to 80 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Has the subject given written informed consent?
- Is the subject between 18 years old and 80 years old inclusive?
- Has the subject had histologically proven HGG with recurrence or progression following initial definitive therapy(s) such as surgery with or without adjuvant radiation therapy and/or chemotherapy (confirmed by diagnostic biopsy or contrast-enhanced MRI and evaluable by Macdonald criteria)? Note, if first recurrence of HGG is documented by MRI, an interval of at least 12 weeks after the end of prior radiation therapy is required unless there is either: i) histopathologic confirmation of recurrent tumor, or ii) new enhancement on MRI outside of the radiotherapy treatment field.
- Does the patient have either (1) a single, enhancing tumor recurrence/progression that is ≤ 8 cm in greatest dimension, or (2) multiple enhancing tumor recurrences/progressions within the same surgical field where the sum of their greatest dimensions is ≤ 8 cm?
- Based on the pre-operative evaluation, is the tumor recurrence/progression a candidate for ≥ 80% resection?
- Has the subject elected not to undergo treatment with the Gliadel® wafer?
- Does the subject have a Karnofsky performance status ≥ 70?
- Does the subject have an absolute neutrophil count (ANC) ≥ 1500/mm3?
- Does the subject have an absolute lymphocyte count ≥ 500/mm3?
- Does the subject have a platelet count ≥ 100,000/mm3?
- Does the subject have a Hgb ≥ 10 g/dL?
- Does the subject have a coagulation profile that would allow for the safe performance of surgery under general anesthesia?
- Does the subject have an estimated glomerular filtration rate of at least 50 mL/min (inclusive) by the Cockcroft-Gault formula?
- Does the subject have an ALT < 3 times the upper limit of the laboratory reference range and total bilirubin < 1.5 mg/dL?
- If the subject is a female of childbearing potential, has she had a negative serum pregnancy test within the past 21 days?
- Is the subject willing to use condoms for contraception for 6 months after receiving Toca 511 or until there is no evidence of the virus in his/her blood, whichever is longer. If the subject is a fertile female, is she willing to use contraception for at least 12 months?
- Is the subject willing and able to abide by the protocol?
- Does the subject have adequate venous access?
Exclusion Criteria:
- Has the subject received cytotoxic chemotherapy within the past 3 weeks (6 weeks for nitrosoureas) of the planned date of vector injection?
- Does the subject have, or has the subject had, within the past 4 weeks any infection requiring antibiotic, antifungal or antiviral therapy?
- Has the subject received Avastin® (bevacizumab) for this recurrence/progression, or within the 4 weeks prior to planned Visit 1?
- Does the subject have any bleeding diathesis, or must the subject take any anticoagulants, or antiplatelet agents, including NSAIDs that cannot be stopped for surgery?
- Does the subject have a history of allergy or intolerance to flucytosine?
- Is the subject HIV positive?
- Does the subject have any gastrointestinal disease that would prevent him or her from being able to swallow or absorb flucytosine?
- Has the subject received any investigational treatment within the past 30 days?
- Is the subject breastfeeding?
- Does the patient have a history of prior malignancy, excluding basal or squamous cell carcinoma of the skin, with an expected survival of less than five years?
Please refer to this study by its ClinicalTrials.gov identifier: NCT01985256
|Contact: Asha Das, MD
|Contact: Mary Rose Keller
|United States, California
|UC Irivine
|Not yet recruiting
|Irvine, California, United States, 92868
|Contact: Cynthia Mann 714-456-6472 firstname.lastname@example.com
|Contact: Daniela Bota, MD, PhD 877-824-9111 email@example.com
|Los Angeles, California, United States, 90095
|Contact: Tim Cloughesy, MD 310-825-5321
|Principal Investigator: Tim Cloughesy, MD
|UC San Diego, Moores Cancer Center
|Not yet recruiting
|San Diego, California, United States, 92093
|Contact: Lara Rose 858-822-6575 email@example.com
|Contact: Santosh Kesari, MD 858-822-7524 firstname.lastname@example.com
|United States, Michigan
|Henry Ford Hospital
|Detroit, Michigan, United States, 48202
|Contact: John Gaggin, RN, BSN 313-916-3731 firstname.lastname@example.com
|Contact: Tiffany Pearce 313-916-1784 firstname.lastname@example.com
|Principal Investigator: Steven N Kalkanis, MD
|United States, New Jersey
|JFK Medical Center New Jersery
|Not yet recruiting
|Edison, New Jersey, United States, 08818
|Contact: Charles Porbeni, MD, MSc 732-321-7000 ext 68897 email@example.com
|Contact: Joseph Landolfi, D.O. 732-321-7000 email@example.com
|United States, Ohio
|Cleveland Clinic Foundation
|Cleveland, Ohio, United States, 44195
|Contact: Cathy Brewer, RN firstname.lastname@example.com
|Principal Investigator: Michael Vogelbaum, MD
No publications provided
|Responsible Party:
|Tocagen Inc.
|ClinicalTrials.gov Identifier:
|NCT01985256 History of Changes
|Other Study ID Numbers:
|Tg 511-13-01
|Study First Received:
|November 8, 2013
|Last Updated:
|September 4, 2015
|Health Authority:
|United States: Food and Drug Administration
Additional relevant MeSH terms:
Neoplasms by Histologic Type
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Anti-Infective Agents
Antifungal Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses
ClinicalTrials.gov processed this record on October 09, 2015


text:
Cheap stocks with upward potential
Women are better investors than men
Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more!
Brandywine Realty Trust (
) will begin trading ex-dividend on July 02, 2013. A cash dividend
payment of $0.15 per share is scheduled to be paid on July 19,
2013. Shareholders who purchased BDN stock prior to the ex-dividend
date are eligible for the cash dividend payment. This marks the
15th quarter that BDN has paid the same dividend. At the current
stock price of $13.52, the dividend yield is 4.44%.
The previous trading day's last sale of BDN was $13.52,
representing a -15.82% decrease from the 52 week high of $16.06 and
a 23.47% increase over the 52 week low of $10.95.
BDN is a part of the Consumer Services sector, which includes
companies such as Simon Property Group, Inc. (
) and American Tower Corporation (REIT) (
). BDN's current earnings per share, an indicator of a company's
profitability, is -$.09. Zacks Investment Research reports BDN's
forecasted earnings growth in 2013 as 1.82%, compared to an
industry average of 7.3%.
For more information on the declaration, record and payment
dates, visit the
Dividend History
Interested in gaining exposure to BDN through an Exchange
Traded Fund [ETF]?
The following ETF(s) have BDN as a top-10 holding:
The top-performing ETF of this group is DES with an increase of
7.9% over the last 100 days. ROOF has the highest percent weighting
of BDN at 3.64%.
Enter up to 25 symbols separated by commas or spaces in the text box below. These symbols will be available during your session for use on applicable pages.
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subset: commoncrawl


text:
by Gerry Mak in New Photography on Thursday 28 October 2010
How does a little Asian guy from suburban New York become as fascinated with hunting, heavy metal, skinheads, and New Jersey as I am? I don't know, but Adam Krause seems to have the same interests. Maybe we should go on a friend date.
Share your favourite cultural finds with the Lost At E Minor community and become famous in the process. Well, kinda.
by Inigo del Castillo
by Rachel Oakley
© 2015 Lost at E Minor | Image Attribution | Privacy Policy


text:
Making It Easier to Make a Difference!
Making It Easier to Make a Difference! Visit the new ECM Services Asset One Stop Shop
Gaye Watanabe 270002ME82 email@example.com Tags:  02-2014 assets ecm services 377 Visits
The new IBM ECM Blog site is live now!
Deepthi Nagarajan 270005NCRR email@example.com Tags:  blog ecm ibm 1,167 Visits
The new IBM ECM Blog site http://ibmecmblog.com/ is live now!
The new blog site will provide you access to all the latest information and news about IBM ECM Products and also interesting blog posts from our IBM ECM Experts and Thought Leaders.
Please update your bookmarks with the link to this new blog site - http://ibmecmblog.com/ as the blogging section of the WW IBM ECM Community would be sunset by end of this week.
The new blog site has exciting features and you can now join the IBM ECM conversations on Twitter! And Don't miss to subscribe to the blog site as you can now receive notifications of new posts exclusively by e-mail!
We look forward to your continued support and request you to share your thoughts and engage with us through this new blog site!
Drive Better Business Outcomes with Case Management
Amrita Ganguly 2700077AW8 email@example.com Tags:  ecm case content2014 1,060 Visits
Today's guest post is courtesy: Michael Green, Offering Team Lead – Enterprise Content Management, IBM
The old saying that "knowledge is power' has never been more true than it is today. Access to the right content is critical to the success of almost every type of organization—and so is maintaining this content over time. Knowledge workers need access to information, and they also need flexible processes so they can customize their approach and achieve the best possible outcome. And yet, businesses depend on the efficiency and consistency of automated processes, which means they need a case management solution that can provide both customization and control.
In addition to gaining access to the right information, knowledge workers need the ability to use analytics to drive even deeper insights and ensure consistent
decision-making. Information helps knowledge workers make better decisions, especially when case types are complex. The next steps and the final outcomes are not predetermined, which makes them unsuitable for automated processes control. Instead, they require knowledge workers to review the documentation and use the analytics to really discern the next steps that set them apart.
Today's forward-thinking businesses are demanding more from advanced case management solutions. In addition to the basic features of a case management solution, business need technology that can:
How can you find an advanced case management solution that can improve the productivity of your knowledge workers and deliver better outcomes? Join IBM Content 2014, coming soon to a city near you, to get the answers. Discover how easy it can be to create truly dynamic tasks, and learn how IBM solutions can help organizations improve mission-critical processes.
Deliver Better Customer Experiences and Self-Service Options with Content Management
Amrita Ganguly 2700077AW8 firstname.lastname@example.com Tags:  contentanalytics ecm content 871 Visits
Today's guest post is courtesy Jill Taylor, Program Director - WW Demand Generation, Enterprise Content Management, IBM
Customer expectations are higher than ever before. People expect you to know them as individuals, they demand relevant, timely promotions, easy-to-use self-service options, and seamless, integrated experiences across every touch point, whether they're using smart phones, tablets or computers. And they assume that these exceptional experiences will remain consistent before, during, and after they make a purchase.
How well is your organization keeping up with the soaring demands of today's customers? Most companies say that "the customer comes first," but do they follow up on that statement with the way they align their business?
Customer-focused organizations create systems of engagement to drive excellent customer experience. That's because mere customer loyalty isn't enough. You need to create brand advocates—people who are willing to share their positive opinions about their interactions with your business to everyone in their extended digital network. They'll remain devoted customers, and they'll also generate more business for you, as well as higher revenues. Here are three pillars of a strong customer engagement system:
What can you do to provide these kinds of customer experiences in order to build lasting loyalty? Join IBM Content 2014, coming soon to a city near you, to get the answers. Learn how IBM's enterprise content management solutions can provide a complete view of your customer so you can anticipate their needs, and discover how secure, reliable self-service solutions can help create satisfied customers—and evangelists for your brand.
IPD for Smarter Process
Deepthi Nagarajan 270005NCRR firstname.lastname@example.com Tags:  business worker impact process ecm knowledge case 2,098 Visits
Image Process Design, Inc. (IPD) will demonstrate IBM Smarter Process solutions at booth 734-1 this year at Impact 2014. IPD, an IBM business partner since 1991, leverages IBM Case Manager (ICM), WebSphere Application Server, Business Process Manager (BPM) and Operational Decision Manager (ODM) to offer clients the benefits of IBM's Smarter Process initiative.
Smarter Process combines world-class IBM technologies to add business intelligence, predictive analytics, enterprise content management (ECM) and master data management to knowledge worker operations. IPD offers packaged solutions that allow clients to realize immediate business benefits from their IBM investments.
IPD Smarter Process solutions for insurance deliver operational transformation across the insurance enterprise, allowing companies to better leverage their IBM technology stack for competitive advantage.
IPD understands the complexity and uniqueness of insurance case and process management use cases. We know they require deep interactions between people, information and regulations to produce optimal business outcomes, better judgment and decision-making. In fact, IPD is one of only a few companies building packaged repeatable solutions for the most complex of use cases in claims, new business / enrollment, underwriting, appeals & grievances and other areas.
Stop by IPD's Impact booth 734-1 to see a demo showcasing how Smarter Process can transform operations and learn more about solutions that best leverage Case, Content, Process and Rules.
About IPD
IPD is a premier IBM business partner with more than 23 years of experience solving complex business challenges for large financial institutions. Our expertise is coupled with a highly referenceable client list and numerous Gartner references.
ECM At Connect 2014: The Convergence of S3
Noah Kuttler 110000SVNJ email@example.com Tags:  ecm connect social 2,509 Visits
That's what voice over artist and actor Miguel Ferrer would say in a deep voice as explosions appeared on camera, but we all agreed it was a bit too much.
Which is not to say that there still are not three awesome things that are about to happen at IBM Connect 2014; and they all begin with the letter 'S.'
Last week, the entire United States of America was assaulted by cold weather. Except for Florida.
As all 48 states, including California, wore blue on the weather map it was Florida that remained a nice orange/red (and it of course prompted a fun "We Hate Florida" meme).
As a former resident of Florida, I can tell you that in January there's no better place to be than the "Sunshine State."
The way that knowledge workers are collaborating and sharing content is continuing to shape how we define what enterprise content management needs to be for our customers.
The document that your user could access two years ago isn't as important as the document they can share today. Or the document that they will collaborate on tomorrow. On the desktop and across mobile devices. Content will be driving what they do and the way you deploy your solutions will be critical for their success.
The theme of the conference this year is "energizing life's work" and as an ECM practitioner it's a great opportunity to learn about new ways to connect people and teams inside and outside your organization to share and innovate with content.
There are a number of things we have planned for ECM at IBM Connect 2014 including exciting sessions with everyone's favorite experience platform IBM Content Navigator as well as other ECM solutions, a keynote from Doug Hunt and a mobile demo that you're going to want to see in person.
Scott Adams
The last 'S' is for Scott Adams, creator of Dilbert! To put it in perspective, Dilbert.com went online in 1995 and was the first syndicated comic strip to also be available on the Internet. Adams was 'social' before we had a word for it. I have no doubt that he'll be funny and we'll all be entertained, but he's also one of the trailblazers of what we do around how, where and why we share content.
Nice weather. Learning about social content management. Dilbert. What are you waiting for?
Session previews are live and registration is open . We look forward to seeing you there.
How can you attend ODUG - OnDemand User Group - Even If You Can't Get to Las Vegas
Deepthi Nagarajan 270005NCRR firstname.lastname@example.com Tags:  cmod odug iod ecm 2,115 Visits
The OnDemand User Group (ODUG) is opening its annual meeting to a wider audience through a special live webcast from IBM's Information On Demand Conference in Las Vegas on November 7, 2013. As a user of IBM Content Manager On Demand(CMOD), you are invited to attend the session and learn more about ODUG.
When: Thursday, Nov 7, 2013, beginning at 8:30 AM PT / 11:30 AM ET
Where: Mandalay Bay Convention Center South in Tropics B
While the annual ODUG meeting has always focused on technical topics, this year the ODUG Board has selected an agenda for live broadcast to a wider audience to bring the benefits of shared experiences and peer networking to more CMOD users.
Several sessions throughout the day will be available to you online:
If you are not able to attend in person, you can register to attend several online sessions below.
8:30 AM - 9:30 AM PT / 11:30 AM - 12:30 PM ET - The New IBM Content Navigator
IBM's Senior Product Manager Ian Story will lead a guided tour of the new IBM Content Navigator and its benefits to CMOD users, including Mobile ECM capabilities, CM8 and CMOD federation, e-Client/pClient replacement functions and much more. Click here to register for this session
1:30 PM - 2:15 PM PT / 4:30 - 5:15 PM ET - Enhanced Retention Panel Discussion
AT&T's Benny Ormson will lead a panel discussion consisting of other CMOD users who have deployed Enhanced Retention features in CMOD.Click here to register for this session
3:45 PM - 4:30 PM PT - 6:45 PM - 7:30 PM ET - Lifecycle Governance Panel Discussion
Lorilei Puthuff of BlueCross BlueShield of South Carolina will lead a panel discussion on best practices for Defensible Disposal and Governance on CMOD. Click here to register for this session.
OR if you think you may want attend IBM Information On Demand this year, click here to register for the conference.
There are CMOD sessions, special events and other CMOD users at IOD who would love to meet you!
How to "Socialize" your content? Learn at IOD 2013
Priyam Modi 2700056E70 firstname.lastname@example.com Tags:  scm ecm #ibmiod 1,362 Visits
Are you looking forward to an effective way to collaborate, leverage expertise and business critical knowledge from any device on any platform? If yes, then the Social Content Management (SCM) track in the ECM forum is the right place to be.
Today, a great deal of content is presented in a variety of social forums on mobile devices, the desktop and the web, and businesses need to exploit that content while ensuring proper governance. Join us IBM and ECM industry experts for compelling conversations on how you can take your business to a whole new level: a social business level.
IOD will be host to some very interesting sessions covering social collaboration and how to deliver trusted content to smart devices and tablets across IBM and CMIS compliant repositories.
Visit IOD and leverage this opportunity to network with peers, know more about the latest technology trends, challenges and case studies in social content management, customer experiences, expert opinions and a lot more.
We recommend you attend the following sessions on Social Content Management:
ESC-3566A A Global Social Collaboration and Content Management Architecture and Deployment Strategy, Wednesday, Nov. 6, 1:45 PM-2:45 PM, Lagoon GH
ESC-3354A: Prudential: Using the Best of Both Worlds, Content and Social, Wednesday, Nov.6, 11:15 AM-12:15 PM, Lagoon F
ESC-3305A: Living Social: It Is Not Just About the Conversations and Topics, Monday, Nov.4, 11:30 AM-12:30PM, Lagoon GH
ECG 3754A: IBM Enterprise Content Management Products and Solutions Strategy, Monday, Nov. 4, 3:30-4:30PM, South Seas F
Also IOD provides you a one-time opportunity to meet 1:1 with IBM executives, subject matter experts and innovative IBM Business Partners. Talk strategy with ECM business leaders, such as Doug Hunt, John Murphy and Carol.Z. Taylor or take a deep dive into SCM with experts from our product and technical teams, including Ian Story, Cengiz Satir and Steve Studer. Don't miss out!
Learn more about Information on Demand
ECM & Mobile - Down With Thumb Drives
Deepthi Nagarajan 270005NCRR email@example.com Tags:  mobile content ecm #ibmiod navigator 1,825 Visits
Ian Story,Senior Product Manager - Enterprise Content Management,IBM
Something struck me the other day - I haven't used a thumb drive in a long time. These little devices used to be staples of our digital lives, and I'm sure I still have one or two floating around in my briefcase somewhere, yet I couldn't tell you the last time I needed one. In today's connected world, I access content when I need to, where I need to, from whatever device I happen to be on. If I need to send a presentation to someone, I share it via a secure link, instead of copying it onto a thumb drive that will get me into trouble if it falls into the wrong hands. If I need to take a document with me on the road, I sync it to my mobile device, or pull it down for offline editing, and never think twice about it.
I don't think this is just me, in fact, I know it is not - in my job as a Product Manager here at IBM, I talk with our clients and prospects many times a week. They are all doing the same sort of thing, and for our customers, it has never been easier to work with your content wherever you happen to be, thanks to IBM Content Navigator. Content Navigator includes Worklight - our cross platform mobile toolkit; it also includes IBM QuickFile for secure file transfer of any document from your ECM system to anyone in the world. Better still, Content Navigator is available on whatever device you need it on, whether it's an iPhone or your laptop in Microsoft Office or an HTML5 web browser on the latest tablet - providing secure access to your content wherever and whenever you need it. And, with both the Worklight toolkit and a native app for iOS, to say nothing of the aforementioned HTML5 UI that works on any modern mobile device, making your content mobile has never been easier.
So, while the thumb drive is dead, I'm not mourning its loss. I'm happy to not worry about losing the latest secret documents on a tiny thumb drive that may fall out of my pocket in a taxi (at least if I lose my mobile phone, I can remote wipe it). Besides, think of all that extra flash memory manufacturing capacity that can be put to a much better use, like building solid state drives for computers, tablets and phones - giving them that instant-on feeling and being much more rugged and less prone to drives failing. Imagine what the world would be like without solid state drives, with a big excess of flash memory capacity that was being built for thumb drives, sitting around with no place to go...ever plugged a thumb drive into your iPad? Nope, me neither. Yet, on a daily basis, I work with my latest documents, collaborating with my peers all around the world, right there on my iPad, even when I'm disconnected on a plane (which happens less and less these days, in-flight Wi-Fi is almost as cool as Content Navigator). Long live mobile enterprise content management, good bye and good riddance to all the amusing keychain drives with various blinking lights, logos, shaped like little animals and so forth.
And last but not least, since I mentioned the boon of in-flight Wi-Fi above, it made me think of going places on airplanes. If you're still reading this, you should be planning to take a plane (or if you're close enough, some other form of transportation like a taxi or ride a horse or something) to Las Vegas in November, to our Information On Demand conference.
Here are some sessions that you should not miss.
ECG-1536A: IBM Content Navigator: The Enterprise Content Management User Experience,Date:6th November 11:15 AM – 12:15 PM, Mandalay Bay H
EIC-1664A: Creating Enterprise Content Management Mobile Applications Using IBM Worklight and IBM Content Navigator,Date: 6th November, 2013, 3:00 PM-4:00 PM,Location: Lagoon AB
EIC-1788A: Enterprise Content Management Mobile Update and Roundtable, Date: 6th November, 2013,10:00 AM-11:00 AM,Location: Lagoon GH
You can see some of this amazing enterprise content management technology for yourself and also a featured demonstration of ECM and mobile in the ECM keynote at the conference.
I'll be there, maybe I'll even hand out a few antique thumb drives as souvenirs - relics from a day long gone!
Mobile & Capture - at IOD...
Scott Blau 270004N498 email@example.com Tags:  imaging datacap capture mfp blau mobile time coca-cola real ecm iod scott 5,376 Visits
It's time to start planning your agenda for Information On Demand 2013 - aka "IOD," in Las Vegas. Whether you are in IT, Operations, or Finance, IOD is a great networking opportunity: meet with peers, industry experts, and influence the architects of your current solutions. Choose between business, technical, and leadership training sessions, or use the event to expand your understanding of Business Analytics, other Enterprise Content Management (ECM) technologies, and Information Management. There are also special events with todays thought leaders. You will be encouraged to "Think Big," but maybe just as important, you can also learn how to "Think Fast."
The main reason to go to IOD? Capture, of course! We're putting the focus on capture in the context of "real-time imaging." What's real-time? That's the time you - and your customers - expect things to happen when they have a smartphone in their hands. Mobile is coming to capture very quickly now. Don't believe me, then come to IOD to see for yourself. We'll be showing that and related distributed/branch capture capabilities and solutions. You'll see what is available today... and if you pay close attention, we'll give you a sneak peak at the future!
Here are some specific real-time imaging sessions to pencil into your agenda... and there are more to come!
Also, be sure to take advantage of the once-a-year opportunity to meet 1:1 with IBM executives, subject matter experts and innovative IBM Business Partners. I'll be there, but you an also talk strategy with other ECM imaging business leaders, such as Brent Bussell, Feri Clayton,Brian Phelps, and Rick Gawronski. Or take a deep dive in to Document Imaging and Capture with experts from our product and technical teams, including Tom Stuart, Ben Antin, Jim Reimer, Charles Wiecha, Bud Paton and Noel Kropf.
Learn more about Information On Demand
For ongoing IOD updates, follow me on Twitter @CaptureGuru.
Big Data in 140 characters or less
Sanjay Kupae 2700050U55 firstname.lastname@example.com Tags:  #bigdata #contentanalytics ecm analytics #ibmiod 2,058 Visits
The thing about twitter is once in a while you come across something that is truly funny and explains what we really struggle to convey in 4 or 6 page whitepapers, one such tweet I came across was by Karen Lopez (Twitter: @datachick)
""HELLO WORLD" on Hadoop should really be "HELLO YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU, YOU" #NoSQLNow
I will put my hand up and say I am geek who get its instantly and all of us who have at some point written a line of code will agree you could not describe personalization driven by Big Data better than that.
The very fact that we are able to process billions of pieces of information to find singular information about people is truly remarkable. The key to personalization is aggregation of information, isolation of facts from the aggregations and recognizing traits, sentiments and features from these facts. The key caveat about personalization is that we need the aggregation of information – demographics, web behavior, offer interaction, historical purchases, social media interactions, service call logs, satisfaction surveys.
Considering one or two sources of information to identify customers or customer types would result in inaccurate descriptions leading less effective personalization and in the end compromising product definition and promotions. Soon, in the Big Data world we will have the ability to aggregate structured and unstructured data and perform advanced analytics like Content Analytics on it- and truly identifying micro-segments of your marketplace and help product designers create products that address the specific needs and marketers can create messages and promotions that excite these micro-segments.
If you want to know more about how Content Analytics analyses information for true insights check out checkout the online demo.
We will be talking about Content Analytics @ IOD 2013 in November, join us in Vegas to converse with a wide range of experts on all things Big Data and Analytics.
The Cost of Capture
Scott Blau 270004N498 email@example.com Tags:  india entry data ocr #capture datacap blau scott capture ecm 2,363 Visits
I'm just back from a trip to India. Until fairly recently, I would never have imagined significant opportunity for document capture in the very place where outsourcing of data entry has been most successful. That's relevant to the document capture business because when a document is "captured" two things happen:
Even banks with far-flung operations and massive workforces are exploring ways to automate aspects of the document capture process: the volumes of documents to be captured are staggering once a bank wades into the world of branch capture. (My thoughts on how branch capture is technically something new in document capture: http://ibm.co/13i74bl.) Automation not only reduces costs, but speeds up the process, ultimately helping improve customer services… and most importantly, customer satisfaction. (And if you are skeptical that customer satisfaction is the underlying benefit of document capture, let me try to convince you: http://ibm.co/10bwmsJ.)
Put another way, in large-scale document capture operations, there is a premium on reducing complexity, including the number of people involved. Globally, the Holy Grail is to grow the number of documents being captured, while meeting that growing need with existing staff.
From my perspective, document capture has come of age when it is being adopted globally, even in markets traditionally noted for the low cost of labor.
To continue the conversation, connect with me on Twitter @captureguru.
How Watson Got His Voice...
Scott Blau 270004N498 firstname.lastname@example.com Tags:  watson blau datacap scott jeopardy capture ocr ecm 3 Comments 5,320 Visits
4 Non-Trivial Questions to Ask before Committing to Production Document Capture
In late 2009 and I got a call from the brother of a good friend. He was a researcher at IBM's Watson Labs - soon to became famous for the "Watson" artificial intelligence engine that spectacularly beat the top humans on the trivia game-show, Jeopardy!
My friend was trying to solve a problem and thought that my company, Datacap (the acquisition of Datacap by IBM was not even on the horizon at this point), could help, since we specialized in optical character recognition (OCR) and related document capture technologies.
I said, "great, let me ask you 3 or 4 questions about what you are trying to do:
1) What is the volume of documents/pages/images you need to process per day, week, month, or year?
2) What data do you need to extract from those pages, any special considerations to take into account?
3) Are the pages consistent in format, variable, something in between?"
He said he had 5000 pages. Clearly to him that was a big number, but he was a bit deflated when I asked, "is that per day?" In the production document capture business, it is definitely common that a volume like that may be literally processed "before breakfast."
But 5000 pages were all he had. Not every day or week, or even every month, just once. I was a little skeptical, but I wanted to learn more.
He needed to extract information from an English language pronunciation guide. He wanted to read the word to be pronounced, and then the linguistically precise definition of the pronunciation, including diacritical marks (accents) commonly used in those definitions. In other words, this was not just straight English language OCR. My skepticism increased.
I wasn't surprised when I next learned that the pages were not at all consistent, that the definitions for a specific word could wrap from one page to the next, or that the pages to be scanned were in bound books...
That was it. Did he really expect to use a production capture product to process - one time - 5000 pages with specialized text and words on them and no fixed format? Well, yes, he did. He had a real challenge and his expectation was not unreasonable... it just is not what production document capture is about.
Those three questions can help anyone quickly assess a document capture problem. In this case, the answer was simple, but perhaps wrong. I advised him that it would not be economically feasible for him to invest in production document capture, but in giving that answer I missed a great opportunity.
Turns out I should have asked a 4th question, "why do you need to read a pronunciation guide?"
I learned later that my friend was working on a major artificial intelligence project, one that would need a computer capable of blurting out words under extreme time pressure. He was, in fact, working on giving "Watson" a voice. It was that voice, having been trained to enunciate thousands of words, that went on prime time to beat the best human players at a live game of Jeopardy!
He eventually used a desktop OCR program and a lot of patience to translate the pronunciation guide from paper to something Watson could understand. Although my 3 questions helped me quickly assess the value of the opportunity, by skipping the 4th question, I missed the opportunity to brag how Datacap helped to give Watson a voice!
Is production document capture and imaging right for you? Click here to learn more on using capture solutions.
A Dual Partnership With A Single Focus: Helping Customers
Sanjay Kupae 2700050U55 firstname.lastname@example.com Tags:  bp analytics ecm content 1,359 Visits
Guest post by Michael Veenswyk, CEO at Integritie
Integritie is happy to participate at ECM's Business Partner Leadership Forum this week. As a long-time partner with IBM, we welcome the opportunity to get a look at the product roadmap and give feedback on future development.
We're also proud to be part of the team that helped with the successful implementation at Security First Insurance announced yesterday. This is a great example of a company with a business problem being helped through a partnership with a single focus – helping customers in need.
Florida has more property and people exposed to hurricanes than any state in the country. People whose homes have been damaged or destroyed by a hurricane are often displaced quickly, with little more than the clothes on their backs. Grabbing an insurance policy on the way out the door is often an afterthought. They're relying on their insurance companies to have the information they need to help them get their lives back in order as quickly as possible.
Security First Insurance had mastered customer service through its call center and web portal but needed help with email and social media. Here's where the partnership came into play.
Integritie configured a solution built on key IBM ECM software components, featuring IBM Content Analytics with Enterprise Search, IBM Content Collector for Email and IBM FileNet Content Manager software. Now called Social Media Capture 4 (SMC4), it offers four critical capabilities for managing social media platforms: capture, control, compliance and communication. For example, it logs all social networking interaction for Security First, captures content, monitors incoming and outgoing messages and archives all communication for compliance review.
The Content Analytics with Enterprise Search software that anchors the SMC4 solution provides the information necessary to help the company identify and address the most urgent cases first. The software automatically sifts through data in email and social media posts, tweets and comments using text mining, text analytics, natural language processing and sentiment analytics to detect words and tones that identify significant property damage or that convey distress. Security First can then prioritize the messages and route them to the proper personnel to provide reassurance, handle complaints or process a claim.
Security First wanted to be available to its customers no matter how they chose to get in touch. Today, policyholders use any means available to connect with an agent or claims representative, including posting a question or comment on the company's Facebook page or Twitter account.
The result? Thanks to a great partnership with IBM, Security First is now one of the first insurance companies in Florida to make themselves available to customers whenever, wherever and however they choose to communicate.
How To Fail Your Customers In 300 Seconds Or Less
Sanjay Kupae 2700050U55 email@example.com Tags:  sanjay analytics content ecm 2,099 Visits
Sanjay Kupae, Category Marketing Manager- Discovery & Analytics, IBM
Good experiences are shared. Bad experiences are shouted.
SHOUTED might not be a strong enough word because as customers are more connected, the speed and scale to which negative customer experiences travel the Internet is frightening.
The biggest source of grief for most customers is when they reach out to your contact center. Most customers are calling your contact center only after a long process of trying to fix their problem themselves. They're ready to shout even before they pick up the phone, so when you call for assistance, time and accuracy are critical to creating an exceptional experience for them.
The contact center call experience is one of the most important activities to build customer loyalty. When that customer reaches out to you, for that brief three- to-five minutes your service associate represents your brand and all it stands for.
The customer is speaking to your service associate because they need answers. Which means your service associate either knows what to say, or more often than not they need to look for the right information, somewhere hidden across the volumes on top of volumes of information spread across silos in your enterprise.
Three hundred seconds is not a lot of time, and it's even less time when your employees don't have the tools.
Content Analytics drives exceptional service experience in two ways –it enhances traditional enterprise search to recognize every piece of information residing in the enterprise and secondly it lets businesses analyze customer interactions to identify service challenges and train associates better.
A recent Aberdeen report says that "For companies with content analytics, the streamlined searching and fast response to queries had a trickle-down effect on several universal business metrics. In the last twelve months, these companies reported a 17% improvement in the accuracy of their business decisions, and a similar improvement in the quality and relevance of their overall analytics program. Furthermore, their data-centric business process – like handling customer complaints, processing invoices, managing inventory, or closing the books – became 12% more efficient. Companies without content analytics reported 2 to 6 times less improvement.
Content Analytics not just improves the customer experience during the interaction with the business, but has a definitive impact on retention, advocacy and revenue.
And it can reduce the shouting...
For more information read the full Aberdeen Group whitepaper or better still visit the Smarter Commerce Global Summit at Nashville , TN between May 21 to 23rd and talk to us


text: Seems to have done something to our 3.3 dashboard. Everything works fine until you click on Syndications or any of its sub categories then everything is all over like it's a problem in a style sheet. WE have the same problem if we collapse the menu. Also, when you sub- categories, everything gets pushed down at least one page so you always have to scroll down to find anything. It does seem to be working fine aside from appearance. WP operates fine and all other plugins/widgets etc work fine. Any ideas?


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The Indiana Pacers are looking for a boost after opening their longest homestand of the season with a pair of overtime losses. They might get a significant one in their next game.
The Pacers might have perennial scoring leader Danny Granger back on the court for the first time this season for Wednesday night's visit from the Charlotte Bobcats.
Granger has spent the first 3 1/2 months of the season recovering from tendinosis in his left knee, and although an exact return date has not been set, a return before this weekend's All-Star break is possible.
How the forward, who has led Indiana (31-21) in scoring in each of the previous five seasons, will be used is also not clear, but he'll likely serve as a reserve initially before replacing Lance Stephenson in the starting lineup. Stephenson is averaging 13.4 points in his last eight games.
"We'll probably bring Danny off the bench for a short-period of time, till he gets his rhythm back," coach Frank Vogel said. "It will probably be only a handful of games."
If Granger, who owns an 18.2-scoring average in seven seasons with the Pacers, plays, he'll try to help his team avoid a third consecutive loss.
Indiana had won five straight and 15 in a row at home before beginning a five-game stay at Bankers Life Fieldhouse with Friday's 100-98 overtime loss to Toronto. Three days later it lost to Brooklyn 89-84 in extra time.
The Pacers missed their final four shots in regulation Monday and let the Nets rally from a four-point deficit in the final 1:03. They then made just 2 of 10 shots in the extra period and finished shooting 34.4 percent - their second-worst showing in Indianapolis.
Paul George was 1 for 10 with five points, while David West had seven on 2-of-11 shooting after being poked in the eye early in the game.
"Today was that day that things just didn't fall," said guard George Hill, who had a team-best 22 points on 9-of-18 shooting. "You can't be upset about it. We got great looks, especially late in the game."
Indiana will try to bounce back against a Charlotte team it's defeated 11 of 12 times. The Pacers have also won eight straight home meetings with the Bobcats (12-39), the latest a 96-88 final Jan. 12.
West recorded his first career triple-double in that game (14 points, 12 rebounds and 10 assists), and he was one of four players to score 15 or more points in a 103-76 rout in Charlotte on Jan. 15.
The Pacers also held the Bobcats to 34.7 percent shooting in that one and have allowed an average of 82.0 points on 37.0 percent shooting in the last six in the series.
Charlotte shot 36.5 percent in the season's first matchup Nov. 2, but Kemba Walker scored 30 to lead the Bobcats to a 90-89 victory.
Walker had 18 points Monday while Byron Mullens scored 25 to go with a career-high 18 rebounds as Charlotte snapped a seven-game skid with a 94-91 victory over visiting Boston.
"We need that from Byron and he can do it. We know he can do it every night," Walker said. "When he has big games like that, you know, I think that gives us a much better chance."
Mullens, who missed the two games against Indiana in January due to a sprained ankle, is averaging 17.6 points in five games after being sidelined the previous 5 1/2-weeks.


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