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Bacillus anthracis is one of the most monomorphic pathogens known. Identification of polymorphisms in its genome is essential for taxonomic classification, for determination of recent evolutionary changes, and for evaluation of pathogenic potency.
In this work three strains of the Bacillus anthracis genome are compared and previously unpublished single nucleotide polymorphisms (SNPs) are revealed. Moreover, it is shown that, despite the highly monomorphic nature of Bacillus anthracis, the SNPs are (1) abundant in the genome and (2) distributed relatively uniformly across the sequence.
The findings support the proposition that SNPs, together with indels and variable number tandem repeats (VNTRs), can be used effectively not only for the differentiation of perfect strain data, but also for the comparison of moderately incomplete, noisy and, in some cases, unknown Bacillus anthracis strains. In the case when the data is of still lower quality, a new DNA sequence fingerprinting approach based on recently introduced markers, based on combinatorial-analytic concepts and called cyclic difference sets, can be used.
Keywords:Bacillus anthracis; cyclic difference sets; DNA sequence homology assessment; DNA sequence markers; SNP; strain comparison
Short Report
I have deeply regretted that I did not proceed far enough at least to understand something of the great leading principles of mathematics; for men thus endowed seem to have an extra sense.
Charles Darwin
This research is part of an effort to develop novel techniques for the interrogation of pathogenic genomes. In this domain the task of Bacillus anthracis strain differentiation poses a particularly difficult challenge [1-4]. Since most B. anthracis strains are highly monomorphic, sequence typing must rely on subtle differences between genomes, sampled at multiple loci [5]. The complexity of the problem will increase in cases where only partial sequence data is available, or sequences contain errors, and as design of engineered bacterial genomes becomes possible [6].
The principal genomic markers used in sequence typing are VNTRs, indels and SNPs. The occurrence of VNTRs and indels in the B. anthracis genome in the three strains considered here was recently investigated in [7]. Here, we undertake the analysis of SNPs. The use of SNPs in both human and microbial DNA investigations has a long tradition [8]. The advantages of SNPs include high concentration in coding regions, fixed length, and lower susceptibility to short read sequencing errors than VNTRs. In applications these advantages must be balanced against SNPs' relatively slow mutation rates and relatively low resolving power. In cases when sequence typing by SNPs is not sufficient, the use of SNPs in combination with other markers should be considered [9].
In this work the occurrence of SNPs is investigated in the three main strains of the B. anthracis genome: Ames Ancestor, Ames and Sterne. It is shown that SNPs are abundant in the B. anthracis genome and that they are distributed relatively uniformly throughout the sequence. These findings demonstrate that the B. anthracis SNPs can be used effectively as part of an increased resolution, multi-tier strain differentiation scheme for the analysis of moderately incomplete, noisy or uncertain data. The SNP detection approach used here is based on an advanced design theory construction known as the cyclic difference set [10]. In this approach the comparison of DNA sequences is replaced by the comparison of cyclic difference set distributions associated with these sequences. The similarity of these distributions is used first to assess DNA sequence homology and subsequently to identify indels and SNPs. The cyclic difference set approach has many advantages [7]; the primary one, which is particularly relevant to this work, is that it permits a high degree of flexibility in selecting an appropriate sequence variation resolution that can be adapted to a given application.
The work described here intersects several application domains. Prior work on B. anthracis includes [7,1,5,11,3], and [12-14]. Prior work on bacterial genome structure includes [15-18]. Prior work on SNP taxonomy and detection includes [8,19,1], and [20]. Prior work on cyclic difference sets includes [10] and [21-23].
The B. anthracis genome is made up of chromosomal DNA and two plasmids, pXO1 and pXO2. We analyzed the chromosomal sequences of Ames Ancestor GenBank: NC_007530.2, Ames GenBank: NC_003997.3, and Sterne GenBank: NC_005945.1, the pXO1 plasmid sequences of Ames Ancestor GenBank: NC_003980 and Sterne GenBank: NC_001496, and the pXO2 plasmid sequences of Ames Ancestor GenBank: NC_003981.1 and Pasteur GenBank: NC_012659.1. For brevity, we refer to Ames Ancestor, Ames, Sterne, and Pasteur as AA, A, S, and P.
SNP definition and taxonomy
There is no standard, mathematically consistent definition of the term SNP [8]. We consider it essential to establish such a definition, so that confusion can be avoided in analysis, in comparison of results and in discussions. In this work a SNP is defined as a single letter difference between two sequences flanked on the left and on the right by at least one letter that is identical in both sequences. For example, in the strings
the second and fourth letters are SNPs but the sixth and seventh letters are indels, as the letter differences are adjacent. This convention is different from general practice, which sometimes permits adjacent letter differences to be regarded as SNPs [8]. We insert the non-adjacency constraint into the SNP definition because: (1) such modification permits mathematically unambiguous separation of SNPs and indels, and (2) such separation is biologically meaningful as adjacent and closely spaced SNPs often coincide with large indels.
The definition of SNP must be further disambiguated when more than two sequences are considered. In this case two or more distinct letters might appear at a putative SNP position, raising the possibility of counting each pair-wise mismatch as a separate SNP. We will ignore this multiplicity. For example, both triples A-C-T and A-C-C will be considered instances of a single SNP. We will distinguish between coding and non-coding SNPs, and between synonymous and non-synonymous SNPs (the latter referred to as nsSNPs). In a three-way comparison a coding SNP is considered non-synonymous when at least one of the pair-wise SNPs is non-synonymous. For example, there are two pair-wise SNPs in letters A-C-C in the three-way comparison of AA-A-S, one for the pair of strains AA-A and one for the pair of strains AA-S. If either of these pair-wise SNPs is non-synonymous then the three-way SNP is declared an nsSNP.
The analysis of the B. anthracis genome was performed using the approach described in [7]. Here, we will give only a brief overview of this approach as it is relevant to SNPs. The algorithm consists of two main stages: indel detection and SNP detection. In the first stage the occurrences of certain short quasi-random strings, called cyclic difference sets (DSs), in two homologous DNA sequences are identified and, subsequently, the locations of these occurrences are compared. The algorithm proceeds as follows:
• In each of the two DNA sequences being compared identify the consecutive occurrences of a selected DS. For example, choosing the DS, 1101000, the DNA sequences
give rise to the DS sequences associated with the nucleotide C,
• Convert the above DS sequences to shorter sequences of inter-DS gaps,
• Align the gap sequences and identify the mismatching strings of gaps, 7 and 5, or (CAC)GGGG and (CAC)GG.
The rationale for using DSs as sequence markers is that when DNA sequences are highly homologous, so are the sequences of DS locations. Conversely, in regions where DNA sequences differ, so do the DS sequences. This is convenient as the analysis of DNA sequences can then be replaced by the analysis of much sparser, and therefore easier to compute, DS sequences. Since a difference in DS sequences marks the occurrence of an indel, mismatching segments are removed from the DS sequences.
In the second stage of the algorithm, the DS sequences are mapped back to "new", indel-free DNA sequences. These DNA sequences differ only by nucleotide mismatches. Once adjacent mismatches are filtered, SNPs are easily identified by a point-wise comparison of the modified nucleotide sequences. In the example given above this yields the indel-free sequences
Point-wise comparison of these sequences reveals a SNP T/A at the 6th bp.
Several comments are necessary here to make statements precise. First, while a more natural acronym for a cyclic difference set would be CDS, to avoid potential confusion with a coding sequence we settle for DS. Second, DSs are combinatorial designs that are associated with, not identical to, the special binary strings considered here. However, for convenience and by abuse of language in this text we will refer to the relevant strings as DSs. While motivating the technical approach, for brevity, we mention here only the computational complexity reason for the utility of DSs.
Specifically, the computational advantage of the method as compared to a direct approach not relying on DSs is proportional to the abundance of DSs in genomes (1 in 500 nucleotides in the B. anthracis genome). This advantage is further enhanced by the suitability of the method for implementation using Fast Fourier Transform algorithm, which requires only n log2 n complex operations. For a more extensive discussion of the role of DSs in DNA sequence analysis the reader is directed to [7].
The results of the SNP analysis of the B. anthracis genome are summarized in Tables 1 and 2. The distributions of the chromosomal SNPs (all and non-synonymous) are shown in Figures 1 and 2. The histogram of distances between subsequent chromosomal SNPs is shown in Figure 3. A list of all SNPs annotated for position, nucleotide letter, coincidence with a coding region, and protein preservation is included in [Additional file 1].
Table 1. Abundance and taxonomy of SNPs in Ames Ancestor, Ames and Sterne genomes reported in [13] and computed using the DS approach.
Table 2. Distribution of SNPs in Ames Ancestor, Ames, and Sterne genomes.
Figure 1. Distribution of SNPs in chromosomal sequences of the B. anthracis genome (A-S). Small blue dots mark AA-S SNPs, large red dots mark AA-A SNPs.
Figure 2. Distribution of nsSNPs in chromosomal sequences of the B. anthracis genome (A-S). Small blue dots mark AA-S SNPs, large red dots mark AA-A SNPs.
Figure 3. Histogram of distances between subsequent SNPs in the B. anthracis chromosome. The minimum, average and maximum distance between subsequent SNPs is 2, 34499 and 163349 bp, respectively, however many SNPs are less than 2000 bp apart.
Additional file 1. Tables of SNPs. Tables of SNPs for chromosomal and plasmid sequences of B. anthracis strains Ames Ancestor, Ames, Sterne, and Pasteur. The GenBank reference numbers of sequences are given in the Data section.
Format: PDF Size: 28KB Download file
This file can be viewed with: Adobe Acrobat Reader
The chromosomal analysis included the three pair-wise comparisons of AA-S, AA-A and A-S. These comparisons revealed 131, 19 and 150 SNPs, respectively (Table 1). The SNPs found in the AA-S and AA-A strain comparisons partition the SNPs found in the A-S strain comparison. This suggests that Ames and Sterne are both descendants of Ames Ancestor. The relatively large number of SNPs in AA-S confirms that AA is evolutionarily more distant from S than from A [1]. About 70% of chromosomal SNPs are coding and about 80% of coding SNPs are non-synonymous. The ratio of all coding SNPs to all SNPs is 67%. This ratio is only modestly lower than the ratio of coding DNA and the entire genome sequence lengths, 78% in the AA strain. This result suggests that there is a similar degree of sequence conservation in the two sequence types. Both SNPs and nsSNPs are relatively uniformly distributed along the chromosome (Figures 1 and 2). The minimum, average and maximum distance between subsequent A-S SNPs is 2, 34499 and 163349 bp, respectively, although many SNPs are less than 2000 bp apart (Figure 3, Table 2). Interestingly, despite the close proximity of several pairs of SNPs, only the SNPs 93 and 94 occur within the same gene. The distributions of SNPs are only negligibly affected by the occurrence of indels. This is so because chromosomal sequences are highly homologous: the AA-A comparison yields only two multi-base indels, a 123-base-long indel at 1151242 bp and a 10-base-long indel at 2612043 bp; the AA-S comparison yields a single 100-base long indel at 4147353 bp (all locations are given in the AA coordinates) [7].
The plasmid analysis included pair-wise comparisons of strains AA-S for pXO1 and AA-P for pXO2. Given their relatively short sequence lengths, the pXO1 and pXO2 plasmids are polymorphism-rich, containing 14 and 21 SNPs each, respectively. Of these SNPs, 7 and 16 are coding SNPs. Of the coding SNPs 6 and 9 are nsSNPs. The minimum, average and maximum distance between subsequent SNPs in the pXO1 plasmid are 3, 12977 and 84568 bp. The minimum, average and maximum distance between subsequent SNPs in the pXO2 plasmid are 94, 4516 and 13884 bp. The density of SNPs decreases in the pXO1 and pXO2 plasmids when indels are removed from the sequences (Table 2). The effect is most pronounced in the pXO1 sequence, due to the occurrence of two large indels at 43348-48589 and 117228-162050 bp.
Overall, when adjusted for indels, SNPs are distributed, rather surprisingly, in a relatively uniform fashion across the entire B. anthracis genome, but with varying inter-SNP spacing in each of the three sequences.
This work describes the structure of B. anthracis SNPs arising from in silico comparison of the Ames Ancestor, Ames and Sterne strains. This result complements the characterization of B. anthracis indels given in [7] and extends the analysis given in [13] in both the number of SNPs identified and the information provided about their type and distribution. While a later work, [24], slightly extends the results of [13], it does so only with respect to the 12 so-called canonical SNPs.
Indels and SNPs, together with VNTRs (The distinction between indels and VNTRs is made for historical reasons; mathematically, VNTR is a special case of indel), capture all sequence differences in pan-genomes (Pan-genome is a superset of all the genes in all the strains of a species [16]. More generally, pan-genome can be defined as a reference genome for a species plus the superset of all the genomic variants occurring in all the strains.). Knowledge of these differences can be used either to address basic biological research problems, e.g., investigation of genomic function and evolutionary processes [12], or in applications such as strain fingerprinting [1] and monitoring of DNA sequence synthesis orders [25]. In each of these problems selecting the appropriate granularity of analysis is one of the main decisions that must be made in experiment design.
While it was previously suggested that many B. anthracis strains, including the ones considered here, can be identified using certain minimal sets of markers, such as the so-called canonical SNPs [5] or special sets of VNTRs [2], such approaches are certain to be effective only when the strain is known and the data is perfect. This might not always be the case. Indeed, in many practical sequence analysis scenarios the data can be Large (whole genome), Uncertain (a new strain), Noisy (contaminated at the source, corrupted in the process of data collection, sequencing or sequence assembly, or purposefully engineered), or Incomplete (LUNI). In these cases a minimum set of markers will not, in general, suffice to identify all strains, and higher resolution approaches, relying on sequence over-sampling, must be employed.
Results of the SNP investigation undertaken here together with the prior work on DSs [7] both inform the design and suggest a certain organization of these approaches (Table 3). As mentioned before, the most parsimonious and - at the same time - the most error-prone strategy for strain differentiating is based on a minimal set of SNPs. This set needs to contain at least n SNPs to be able to differentiate 2n strains, provided the data is of sufficient quality to accurately represent the required SNPs. One can improve the resolution of this scheme, at the cost of increasing its complexity, by extending the minimal set of SNPs to the set of all known standard genomic differences. Aided by a roughly ten to hundred-fold increase (depending on the strains under consideration) in the sampling rate, this approach can be expected to be effective in the case of closely related strains whose sequence data is of moderate quality or partly unavailable (which might include sequence segments containing SNPs from the minimal set). Exceptionally complex tasks, such as detection of data manipulation or revelation of unknown distant strains, will require the use of even more dense, uniform and flexible sequence sampling schemes. One such scheme is offered by the DS-based sequence homology assessment procedure [7]. In this approach the average marker spacing can be selected from the range of tens to tens of thousands of nucleotides. This approach will be effective in all but the most challenging sequence analysis scenarios.
Table 3. DNA sequence fingerprinting scheme choices for three strains of the B. anthracis chromosomal sequence ordered in terms of increasing sequence resolution.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
AKB conceived the approach. AKB and JF implemented and tested the method and wrote the manuscript. Both authors read and approved the final manuscript.
The authors would like to thank Julie DelVecchio Savage and Alan Moore for support of this work, and Alfred Steinberg for discussion of pathogenic polymorphisms. The DS approach was inspired, in part, by ideas expressed in the Antoine Danchin' book Delphic boat.
Keim P, Van Ert MN, Pearson T, Vogler AJ, Huynh LY, Wagner DM: Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scales.
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Phoenix Rising: Netroots draws attention to Arizona immigration struggle
Netroots Nation, the gathering of progressive activists and bloggers, is heading into its 10th year in Phoenix this week.
Bernie Sanders draws 11,000 in red state Arizona
Arizona, a traditionally deep red state, has not seen the last of Bernie Sanders.
Arizona mural dramatizes killings by border agents
"Mother Demands Justice" was the theme of a press conference and protest at the unveiling of a large public mural in downtown Tucson commemorating the murder of a Mexican teen.
Sheriff Joe Arpaio found guilty of racial profiling
The ruling comes following a three-week trial in July and August over a pattern of unlawful practices by Arpaio and the Maricopa County Sheriff's Office on immigration sweeps and traffic stops.
Fear, then hope for an immigrant family
After the abduction of her mother by ICE Jan. 10, Erika Andiola got in touch with other immigrants' rights activists, and within hours a nationwide network was mobilized.
Voter suppression scandal rocks Arizona
Unlike other Americans, Arizonans were not able to wake up the next morning to news of the state's election results.
How about a Puerto Rican senator from Arizona?
The first-ever U.S. senator of Puerto Rican descent - elected not from New York, Massachusetts, or Illinois, but from Arizona.
After Court smackdown of Arizona, DREAMers speak out
President Obama recently ordered an end to deportation of young people who have been brought to this country as children.
Supreme Court strikes down most of Arizona immigration law
The U.S. Supreme Court struck down three parts of Arizona's immigration law today, but permitted one of the key parts to stand in a split decision.
Arizona rallies against war on women
Over 300 women and men braved the hot Arizona sun on Apr. 28 to call for an end to the the Republican Party's "war on women."

subset: commoncrawl


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text:
The year 2011 has been one of the more memorable years experienced by this writer. The social happenings, the political events and the economy all worked together to make it a year to remember. This is not a commentary on those events, but these essays have been affected by the events. These are simply stories I have told from time to time, and would tell to my children and grand-children if they were inclined to listen. They aren't so inclined. So, I'm hoping that some day they will pick this book up and read it, along with others I have written, and say to themselves, "So, that's where I came from. That's who I am."
Hershel Franklin, former lawyer and theologian, resides in Washington, Oklahoma, with his wife and two children. You may correspond with Hershel via the internet at email@example.com
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Charlie Published July 25, 2012
Mortimer's Story Published August 09, 2011
One Dog's Story Published March 29, 2011
Thoughts I Thunk Published January 10, 2011
The Warrior Band Published February 17, 2010
Recognitions of Clement Volume 1 Published October 10, 2009


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Fire. Why you hatin?
Not sure how this is an "interpolation" of Ice Cream... He's nice though he's a talented emcee. He reminds me a bit of Talib. Just needs to keep diversifying
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text:
Tools and techniques for performance tuning in Linux
Too Many Cache Misses?
The performance of the system is highly dependent on the effectiveness of the cache. Any cache miss will degrade performance and lead to a CPU stall.
Sometimes a cache miss is caused by frequently used fields located in data structures that span across the cache line. Oprofile can diagnose this kind of problem.
Again, using the Intel Core 2 processor as an example, choose the event LLC_MISSES to profile all the L2 cache requests that miss the L2 cache. For the exact event to use, you should invoke opcontrol --list-events to read about the details of each event type available for your CPU.
Listing 5 shows how to call up a cache miss profile.
Oprofile is a very versatile tool. By carefully choosing which events to monitor, you can zero in on the CPU operation that is causing the problem.
Listing 5
Cache Miss Profile
01 #opreport -l 02 CPU: Core 2, speed 1801 MHz (estimated) 03 Counted L2_RQSTS events (number of L2 cache requests) with a unit mask of 0x41 04 (multiple flags) count 90050 05 samples % app name symbol name 06 2803 63.4163 cc1 (no symbols) 07 190 4.2986 vmlinux-2.6.25-rc9-ltop get_page_from_freelist 08 102 2.3077 as (no symbols) 09 60 1.3575 vmlinux-2.6.25-rc9-ltop __lock_acquire 10 53 1.1991 libc-2.7.so strcmp 11 39 0.8824 vmlinux-2.6.25-rc9-ltop unmap_vmas 12 38 0.8597 vmlinux-2.6.25-rc9-ltop list_del
Locking Problems
A high context switching rate, relative to the number of running processes, is undesirable and could indicate a lock contention problem. To determine the most contended locks, enable the lock statistics in the kernel, which will give you insight into what is causing the lock contention. To do so, use the lock_stat feature in 2.6.23 or later kernels. First, you'll need to recompile the kernel with the CONFIG_LOCK_STAT=y option. Then, before running the workloads, clear the statistics with:
#echo 0 > /proc/lock_stat
After running the workload, review the lock statistics with the following command:
#cat /proc/lock_stat
The output of the preceding command is a list of locks in the kernel sorted by the number of contentions. For each lock, you will see the number of contentions, as well as the shortest, maximum, and cumulative wait time for a contention. In addition, you will see the number of acquisitions, as well as the minimum, maximum, and cumulative hold times for a lock. The top call sites of the lock are also given to let you locate quickly where in the kernel the lock occurs.
It is worth noting that the lock statistics infrastructure incurs overhead. Once you have finished hunting for locks, you should disable this feature to maximize performance.
Excessive Latency
Program throughput that is inconsistent and sputters, applications that seem to go to sleep before coming alive, and a lot of processes under the blocked column in vmstat are often signs of latency in the system. LatencyTOP is a new tool that helps diagnose latency issues.
Starting with the 2.6.25 kernel, you can compile LatencyTOP support into the kernel by enabling the CONFIG_HAVE_LATENCYTOP_SUPPORT=y and CONFIG_LATENCYTOP=y options in the kernel configuration. After booting up the kernel with LatencyTOP capability, you can trace latency in the workload with a userspace latency tracing tool from the LatencyTOP website [2]. To start, compile the tool, do a make install of the LatencyTOP program, and run the following as root:
The LatencyTOP program's top screen (Figure 2) provides a periodic dump of the top causes that lead to processes being blocked, sorted by the maximum blocked time for each cause. Also, you'll find information on the percentage of time a particular cause contributed to the total blocked time. The bottom screen provides similar information on a per-process basis.
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Bugzilla Bug
Bug database has a bug of its own that could allow an intruder to create an unauthorized account.
US Launches New Strategy for Broadband Access
Report focuses federal resources on achieving universal Internet access.
RC4 Finally Gets the Fork
Leading browser makers say "no" to porous encryption algorithm
IBM Says TOR Network a Vehicle for Ransomware
Report from the X-Force group says attackers are using TOR to hide their crimes
Mozilla Announces new Firefox API
Future Firefox extensions will be compatible with Chrome.
Weird Security Flaw Affected Intel Chips for 16 Years
Better read this if you bought your computer before 2011
OpenSSH 7.0 Secure Shell Arrives
Users should upgrade to the new version as soon as possible
Qemu Flaw Lets the Guest Escape
Xen project announces a privilege escalation problem for Qemu host systems
Android Bug Threatens Millions of Users
Attackers can compromise an Android phone just by sending a text message
Lenovo and Canonical Announce Laptop Deal
PC vendor will pre-install Ubuntu on portables in India.


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text:
Every morning, caregivers were asked to rate his/her child's symptoms of sneezing, nasal stuffiness, discharge, and itching over the last 24 hours (reflective). Patients' symptoms were also rated at the time immediately before receiving their daily medication (instantaneous).
Over four weeks, patients treated with Nasacort AQ showed a statistically significant (P=0.0328) reduction in the combined symptoms of sneezing, nasal stuffiness, discharge and itching (Total Symptom Score or TSS) measured over the last 24 (-2.31 plus or minus 0.15) compared to placebo (-1.87 plus or minus .151). Immediately before receiving the daily treatment, patients treated with Nasacort AQ also reported a numeric, albeit not statistically significant (P= 0.0946), reduction (-2.28 plus or minus 0.16) in TSS compared to placebo (-1.92 plus or minus .16).
Side effects among patients treated with Nasacort AQ were similar to those given placebo and no serious adverse events or clinically meaningful changes in vital signs were reported in either group. Side effects associated with treatment occurred in 50.8% of patients receiving Nasacort AQ and 48.3% of subjects receiving placebo. The most common treatment-related adverse events during the 4-week of treatment with Nasacort AQ and placebo respectively were cough (7.6%, 9.2%), pyrexia (fever) (6.8%, 8%), headache (5.5%, 4.2%), and nasopharyngitis (nose & throat irritation) (5.1%, 3.8%).
In a subset of the same clinical study, Nasacort AQ showed no significant effect on average adrenal function in children aged 2-5 years with year-round allergic rhinitis
Also presented at ACAAI is a report on the effect of Nasacort AQ on
|SOURCE sanofi-aventis
Copyright©2007 PR Newswire.
All rights reserved


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Vicky Cristina Barcelona
Wow, this film sure did fool the shit out of me. Here I was expecting a lesbian scene every 10 minutes and actual usage of the dominating chests of Penelope Cruz and Scarlett Johansson. Nope. And even though I didn't know Rebecca Hall was in this movie, it didn't even matter in the end. She wears a fine t-shirt, that's about all I got for her. They are all beautiful ladies though. Yup.
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"Cash or credit? Punt or go for first down? Deal or no deal? Life is filled with puzzling choices. Reporting from the frontiers of neuroscience and armed with riveting case studies of how pilots, quarterbacks, and others act under fire, Jonah Lehrer presents a dazzlingly authoritative and accessible account of how we make decisions, what's happening in our heads as we do so, and how we might all become better 'deciders.' Luckily, this one's a no-brainer: Read this book."—Tom Vanderbilt, author of Traffic: Why We Drive the Way We Do (and What It Says About Us)
"Over the past two decades, research in neuroscience and behavioral economics has revolutionized our understanding of human decision making. Jonah Lehrer brings it all together in this insightful and enjoyable book, giving readers the information they need to make the smartest decisions."—Antonio Damasio, author of Descartes' Error and Looking for Spinoza
"Jonah Lehrer ingeniously weaves neuroscience, sports, war, psychology, and politics into a fascinating tale of human decision making. In the process, he makes us much wiser."—Dan Ariely, author of Predictably Irrational
"Should we go with instinct or analysis? The answer, Lehrer explains, in this smart and delightfully readable book, is that it depends on the situation. Knowing which method works best in which case is not just useful but fascinating. Lehrer proves once again that he's a master storyteller and one of the best guides to the practical lessons from new neuroscience."—Chris Anderson, editor in chief of Wired and author of The Long Tail
"As Lehrer describes in fluid prose, the brain's reasoning centers are easily fooled, often making judgments based on nonrational factors like presentation (a sales pitch or packaging)...Lehrer is a delight to read, and this is a fascinating book (some of which appeared recently, in a slightly different form, in the New Yorker) that will help everyone better understand themselves and their decision making." —Publisher's Weekly, starred review
Jonah Lehrer is a Contributing Editor at Wired and a frequent contributor to The New Yorker. He writes the Head Case column for The Wall Street Journal and regularly appears on WNYC's Radiolab. His writing has also appeared in Nature, The New York Times Magazine, Scientific American and Outside. He's the author of two previous books, Proust Was A Neuroscientist and How We Decide. He graduated from Columbia University and attended Oxford as a Rhodes Scholar.See all Product Description
We spend our whole life trying to figure out how our mind works. This book is an open door to understand the mechanic of it. Read morePublished on Jan. 26 2013 by Cognacazur
This book is well written and easy to understand. Complicated science of the activity of the brain and what affects our brain activity is presented in lay terminology and... Read morePublished on Feb. 5 2012 by Betty
Haven't finished reading it yet(3/4) but the situation used as examples for how the work do that it does are very interesting to say the least. Read morePublished on Nov. 1 2010 by Vincent Lachapelle
As others have noted, this book is quite good at explaining not only "how we decide," but more important, how we decide wisely or foolishly. Read morePublished on April 22 2010 by Michael W. Perry
This is an excellent, authoritative yet entertaining text on a complex and perhaps controversial topic. Read morePublished on Aug. 20 2009 by D. E. Huggins
This is very well written and referenced. This is a book about how parts of the brain affect decision-making. Different types of decisions may require different methods. Read morePublished on May 1 2009 by Karen M. Cooper
Don't just Blink! Instead, read a series of well-chosen, beautifully told stories of successful and unsuccessful decision practices, along with some rules of thumb for when to rely... Read morePublished on April 21 2009 by Donald Mitchell


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Botsford News Release
Farmington Hills, Mich. (February 28, 2013)---Botsford Hospital welcomes spring with its first Walk with a Doc of the season on March 21. At this free community walk, Dr. Annie A. Arrey-Mensah, a board-certified allergist-immunologist, will tell you everything you want to know about asthma and allergies. Dr. Arrey-Mensah will also field your questions.
Walk with a Doc events are held at the Heritage Park Nature Center in Farmington Hills. The park is on the west side of Farmington Road, between 10 and 11 Mile Roads. Look for Walk with a Doc dates at noon on the third Thursday of every month through November. Walks held rain or shine. Healthy snacks provided. Register by calling Botsford at 877-477-Doc1 (3621), option #1.
Beaumont Health is a not-for-profit organization formed by Beaumont Health System, Botsford Health Care and Oakwood Healthcare to provide high-quality, efficient, accessible services in a caring environment for southeastern Michigan residents and beyond. As one of Beaumont Health's eight hospitals, Botsford Hospital is a multi-specialty 330-bed hospital and verified trauma center located in Farmington Hills, Michigan. The campus also houses an imaging center, a comprehensive care cancer center and an extensive medical education program---part of Michigan State University's Statewide Campus System. Annually, Botsford cares for about 16,000 inpatients and more than 60,000 emergency and trauma patients with a team of approximately 2,500 employees, 300 volunteers and 600 physicians.
botsford.org, twitter, facebook, blog
MEDIA CONTACT: Lynn C. Anderson, Director, Marketing & Public Relations or Beth Montalvo, Publications & Media Relations Coordinator
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- マルタ
- セントジュリアン
- 39 Main Street,
- Balluta Bay
- マップ
- 電話: (356) 2311 0000
- お問い合せ
- お知らせ
- 10:55 hrs
Rated 4.2 out of 5 by 151 reviewers.
Rated 5 out of 5 by supatight80 Now this property knows how to treat a Platinum100 Ambassador Guest! When i checked in, no less than 3 people introduced themselves to me and called me and offered me any drink of my choice as a freebie! Then the lead front desk agent introduced me to the concierge as an Ambassador Guest who then showed me the property premises. Upgraded to a HUGE suite with 2 balconies, 2 FULL bathrooms and on top of that, they comped my breakfast plus 500 points! The view was sooo nice as well. I LUV it! May 14, 2015
Rated 5 out of 5 by ppgmg Great value and great service I was attending an event at the Portomaso casino and had a choice between staying at this hotel (which is a nice 15 minute walk along the bay) or a closer one. I ended up choosing the Meridien as the SPG point options were more attractive. I was not disappointed. It's not the W of course, but much nicer than many of the North American category 3s I have stayed at. What really stood out was the service -- very professional service at the front desk (Gabriel and Kevin), a friendly concierge who addresses you by name (Innocent), and hard working staff in the Club Lounge (Aida). What made the stay even better was all the little things: wine and chocolates in the room, anticipating my need for a North American adaptor, cappuccinos and welcome drinks in the lounge, a chat with the chef on Maltese night in the restaurant, 20% off all food with an SPG card, and ensuring my request for a feather-free room was met before I arrived. As a platinum member, I appreciated the room upgrade (great view) as well as the breakfast options. I also "splurged" on a spa package, and that was excellent and frankly, amazing value! I did note that the pool in the spa was a bit of a zoo... I don't think it was restricted to paying spa guests. No big deal, but be forewarned. Many nice restaurants around. Easy to get to sightseeing buses, Would definitely stay here again! March 31, 2015
Rated 1 out of 5 by Cram This hotel does not deserve at all the SPG category 3 Hotel is totally worn-out, everything is faded (would need a big maintenance work), residual smell of sewage inefficiency, breakfast restaurant was awful (big waiting time because of lack of personnel to clean up tables, poor choice). Other restaurant closed for 5 days; except for New Years Eve and the food and beverage experience was extremely poor January 2, 2015
Rated 5 out of 5 by ConnieMae Very Satisfied Customer Just enjoyed a last-minute week-long break at Le Meridien. We were given a really lovely room with a large balcony overlooking Balluta Bay and, although almost December, it was warm enough to sit out and enjoy some late sun. We didn't use the pool but the roof-top terrace and pool area is amazing. Standards at the hotel are extremely high and all of the staff we encountered were exceptionally professional, courteous and helpful - attention to detail and desire to ensure that your stay is as good as it can possibly be. The breakfast buffet had a vast array of foods to choose from including some cooked to order as you required - really delicious and very much spoilt for choice of what to have. We celebrated our wedding anniversary and wine and chocolates were delivered to our room by the hotel - a really nice touch! November 30, 2014
Rated 5 out of 5 by TjP56 Overal a good hotel Excellent service, provided by a very professional team. Several concerns about the room were very quickly dealt with from changing the room to a non-smoking one, requesting extra tea & coffee to adding breakfast to our stay. The only concern that does need addressing (and we have come across this with one other 5 star hotels in Malta that we no longer stay during the winter months) and that is the total absence of any heating for the chilly evenings in November. Our request was met with the fact there was only cooling facility to the air-con until a changeover was made later in the year and the receptionist could not tell me when that would be! There were no heaters available and therefore put your coat on? If Malta & the Meridien want to impress the tourist industry, (there was a large delegation being entertained during our stay) and stand out as a true 5 star and not a Maltese 5 star hotel this needs to be addressed. Not sure how one of the travel industry representatives would have been dealt with if they felt a chill in their room? November 21, 2014
Rated 5 out of 5 by MAWe Excellent Holiday This is the forth time we have stayed at the Le Meridien, we can only praise all the staff for a very warm and welcome on arrival. Facilities excellent - service first class. The Ideal hotel for a holiday views and local service great, will surely visit them again in the near future. Thanks Le Meridien. November 19, 2014
Rated 5 out of 5 by Ger1 Excellent short stay. 4 day stay in October. Great room with terrace and sea views. All staff were very attentive and friendly. Breakfasts were super. Will definately return for another great break. October 20, 2014
Rated 5 out of 5 by STEFFL for sure a GREAT little getaway Perfect location. Great rooms, Great staff that is multilingual and very helpful at all times, parking for free of rental car at property and the view looking out the med sea was just perfect. This sure was the most prositive surprise we ever had at any hotel in the last year while on tour. being recognized as a "guest" sure makes a big difference. We felt very welcomed! October 19, 2014
Rated 5 out of 5 by Kevanfm A very good place to stay At first concerned that we did not have a sea view room, we came to appreciate the quite room overlooking the car park. all staff were very attentive especially Joseph on front desk and Rita in restaurant. Brian our barman was fantastic. We shall surely visit again soon, but why don't you promote The Villa? October 13, 2014
Rated 3 out of 5 by SH81 Only stay here if you don't need WIFI Very bad WIFI quality. Came here with my partner as he was on business and almost every day they had to reset the router so that the WiFi would work for a few hours then stop. October 7, 2014
Rated 5 out of 5 by MKL2014 Classic & Classy Comfort With 5 hard work days in a row - it was a pelasure to come back to my room and relax on the balcony (not something I normally do. A great hotel, well situatued, with proactive, friendly staff. Service was quick and always beyond expectations. Highly recommended for business and pleasure. September 30, 2014
Rated 5 out of 5 by W1961 this hotel is in an excellent location with great features location is great, in the middle of every thing.. close enough to get by bus or take walks.. the only disadvantage is no internet in the rooms, but you have it in the lobby.. one of the beds was not comfortable, and squeaky. other that that it was an excellent, enjoyable stay. September 26, 2014
Rated 5 out of 5 by Darek I recommend to all very good location, free parking for guests, swimming pool on the 12th floor , good breakfst is a small island, it does not pay to rent a car in particular that drive on the left side as in England September 20, 2014
Rated 5 out of 5 by JEM54 STAFF MAKE THIS HOTEL VERY ENJOYABLE We have stayed at this hotel a number of times and find the quality consistently good. The staff are friendly and extremely helpful. September 19, 2014
Rated 5 out of 5 by trevandbabs Good location for local amenities. Hotel has a full range of quality facilities with comfortable, spacious well equipped rooms, splendid food, and a happy and willing staff who are anxious to please. September 13, 2014
Rated 5 out of 5 by zach1201 Six Night Stay at Le Meridien St. Julians We stayed a total of 6 days at the Le Meridien and booked our stay through Starwood Preferred Guest using our SPG points. When we arrived, we were pleased to be upgraded to an executive suite, which comes with access to the executive suite lounge. The lounge included breakfast and light lunch, which included a free open bar. The room, itself, was very nice with a king size bed that was to our liking (we like firm mattresses) as well as a separate bath and shower. Our view had a balcony which overlooked the bay. The hotel staff was very friendly and accommodating to our needs. Within the hotel was a spa, which we used twice. There is also a sightseeing office where you can book trips through. The public bus is just outside of the hotel, there is a small bay/beach area that is open to the public outside the hotel (and many others within walking distance). Many shops/restaurants in the area nearby. September 10, 2014
Rated 5 out of 5 by Edurne great stay It was a very comfortable and pleasant stay. Great staff and great conditions for SPG gold members. The staff at the executive room (Amparo) was simply excellent. August 27, 2014
Rated 4 out of 5 by Vinnie27 Return Stay The LeMeridian and staff certainly rank amongst the best in the world and hotels I ever stayed in. I had a 6 night stay and this was magnificent as was the room. Tony, the concierge,, was remarkable and displayed top rank people skills. The chasing of the lost luggage by Emirates was astounding and fund in our room the next day after our first day out. The only comment I have if I had to make one is that on our return stay after a Europe trip and for our last 3 nights, the room requested was admittedly booked with limited sea views only we found ourselves in a room at the back with no glimpse of water anywhere. Seriously not an issue and would never deter me from staying at the Le Meriian St Julians. In fact. I now know precisely what room to book and look forward to my return. The events manager Cristine was also extremely helpful in organising a small family get together. I was amazed at the amount of effort and attention she gave regardless of the small number. Congratulations, Le Meridian St Julians. Top class August 10, 2014
Rated 4 out of 5 by mijak Good fancy hotel Great rooms, superb breakfast, may be the best I have had. Good concerge service. Nice Pool area on the roof, very central location. We had to wait for a long time to get the rooms on the day we checked in, seemed they were a bit overbooked. Also when asking for someone to pick up laundry we called three times within one and a half hours and the reception always said they would send someone right away, but no one came. Appart for these two inconvinices the staff were always very polite and service minded. I would stay there again. August 6, 2014
Rated 5 out of 5 by Lyns35 Feedback The whole Le Meridien experience is just fabulous - from check in to check out and everything in between! August 5, 2014
Rated 5 out of 5 by TravelFin Great location and friendly staff We enjoyed our stay at le Meridien St Julians for almost 2 weeks. Hotel location was perfect; all restaurants are within walking distance, and you can also reach several swimming locations by walking from the hotel. All staff at the hotel were super friendly, and we really felt like special guests with my husband. Breakfast was excellent. Spa was also nice, only the gym was a bit small and over crowded since the locals also visit it. August 4, 2014
Rated 5 out of 5 by canuckle Outstanding stay at great hotel I have just returned from a stay at this hotel and I am very pleased to say that this Platinum SPG member was treated very well and I would not hesitate to come back again next time. From the start (actually, I emailed the hotel a couple days in advance to ask about transportation and tourist information), the hotel was responsive and professional. At check-in, my room was not ready, but they were happy to let me use the Executive lounge if I needed. I opted to go sight-seeing and was greeted by Mario, with whom i had communicate via email. He gave a warm welcome and gave me a quick primer on the locale and how to get to Valetta, the main town. He also gave me very valuable information on how to get last minute tickets to the Hypogeum - the most sought after tourist site in Malta. When I did get my room, I was very surprised to get a huge suite overlooking the bay area. The 1BR, 2 bath suite was huge and included 2 balconies to lounge at the end of the day. The complimentary canapes and wine in my room was another stunning touch of welcomeness. The breakfast buffet was one of the largest I have seen and like the rest of the hotel, the staff were very friendly, even remembering what I liked to drink on subsequent days. I could continue to rave about the hotel (outdoor and indoor pools, nice spa....) but overall, this hotel does it right! It was sad to leave the hotel as this was one of the most memorable stays I have had (I spend about 2 months a year in hotels). I booked a hotel taxi and did not realize Le Meridien uses its own service of Mercedes vehicles. The cost was not much different than the regular price but the service was, again, superb. Overall, this hotel and the staff were amazing. It is centrally located near Valetta, but also has its own charms in St Julians/Paceville for local cuisine. The cost was very economical, despite being one of the top properties in Malta. August 3, 2014
Rated 4 out of 5 by Smith49 Very good location. I would recommend this hotel for the convienient location. August 3, 2014
Rated 5 out of 5 by Sweden2014 The view from balcony was amazing. View from hotel balcony towards the bay was outstanding. The steam sauna in Spa area was very good and also the indoor swimming pool with its lovely smell was really relaxed. The bay directly outside the hotel was a very good place to start the day at. However the bay is not a natural beach and to get to the water you have to go on old stony stairs to get there. The sea water was clean and perfect. It was therefore worth taking this risk. Spa facility at the hotel was fantastic ! July 31, 2014
Rated 4 out of 5 by GeordieKeith Great Location The hotel is in a great location in St Julian's, just off the front, overlooking Balluta Bay. We had a sea view & large balcony. The staff were very friendly & helpful. The bed was firm, which we like, but the pillows were less than useless. Breakfast was disappointing. While there was a reasonable choice, the quality was lacking, e.g. tinned fruit! July 26, 2014
Rated 5 out of 5 by asda Great stay at Le Meridien St Julians Perfect Hotel to explore Malta. July 21, 2014
Rated 5 out of 5 by uy77 excellent location, by foot and by bus to be recomanded. suits to families and older people July 20, 2014
Rated 5 out of 5 by Lorenzo73 First Class This is an excellent hotel in terms of staff friendly and helpful approach, its location next to the beautiful St.Julian's but away from the noise, and for once easy parking, which if you know this area, is a great advantage. Our room was superb and I would hope to stay again. July 19, 2014
Rated 4 out of 5 by BartBelgium wonderful vacation (single traveller) I am a single traveller. Normally the rooms for single use are very basic. In Meridien St Julian's they give me a free upgrade to an executieve room. Thank you very much for that. It was very relaxing My stay was very good and wonderful. Very good location for visiting Malta. Well done to all staff. I took half board. The breakfast and dinner were excellent. I will return in the future and i will recommend this hotel ! July 16, 2014
Rated 5 out of 5 by katem enjoyable stay We have just returned from a very enjoyable stay in your wonderful hotel and Spa Our room was really comfortable and The bathroom was well stocked a wonderful seaview. Your staff were realy friendly and helpful. The reception staff were really antentive however our registration was rather confusing as we found the information was not clearly inparted to us. We would definately return to Le Meridian July 15, 2014


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Stolen urn returned
NORTH KITSAP - An urn stolen from a 66-year-old Poulsbo man's house during a burglary Friday was returned to him Sunday night.
The man said the urn contained his late wife's ashes.
The urn was found by employees from the La-Z-Boy furniture store on Randall Way. They told police the urn was near a Dumpster behind the furniture store.
A rifle, $25 worth of change, collectible Seattle Mariners bobbleheads and handmade fishing poles are still missing from the home.
The 66-year-old said he's lived in the same house on Kinman Road in Poulsbo for the past 37 years. The sheriff's office is investigating the case.
Subscribe to the Kitsap Sun
Need Help? Call us at 1-877-304-7764.
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To make reservations by phone, call 1-888-287-9400 in the USA and Canada (or any of our worldwide reservation telephone numbers).
It Pays to Book Direct™
It Pays to Book Direct™
SpringHill Suites Cincinnati Airport South
7492 Turfway Road
Florence, Kentucky 41042 USA
7492 Turfway Road
Florence, Kentucky 41042
Cincinnati/Northern Kentucky International Airport - CVG
Airport Phone: +1 859 767 3151
Hotel direction: 5 miles SE
Exit the Airport, take the Donaldson Rd. Ramp, Right on Donaldson Rd. 3 miles to Turfway Rd., Right on Turfway Rd. Follow Turfway Rd., approx 3miles, hotel entrance on left just past entrance to Turfway Park Race Course.
For more information call the general manager of the hotel


text:
Chuck Strouse
Latest Stories
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Vice President Joe Biden, he of the thinning pate and big mouth, will be in South Florida today with a three-fold assignment: to push the Iran nuclear arms deal, to address Miami-Dade College, and garner money for U.S. Senate candidates. Wha...
2 months ago | Crime
A panel on Gamergate, the highly controversial debate over sexism and journalism in the video game world, had to be canceled Saturday after bomb threats. But planners of the panel at Little Havana's Koubek Center, part of Miami-Dade College, didn'...
10 months ago | El Jefe
Just two days before Christmas, in one of those delicious stories the internet was built for, the popular website Bleacher Report -- and some guy (from Portland, Oregon!) named Tom Sunnergran, dropped a bomb on Heat small forward Danny Granger. "D...
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(Update: Chaz Adams, Fort Lauderdale's public affairs manager, sent the following response to this story: To clarify, the meeting was called by Commissioner Trantalis as a District 2 meeting and not coordinated with any other Commissioner or the M...
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The Florida Supreme Court fired a shot across the bow of Broward Sheriff Scott Israel yesterday. In a 5-2 decision, the court ruled BSO cops had no right to stop and arrest Shawn Tracey, whom they stopped with a brick of cocaine and $23,000 cash. ...
1 year ago | El Jefe
Alan Cherry was a gruff son of a bitch. He was smart. Broward County politicians -- particularly cops -- quaked when they heard his name. Cherry died this past weekend. He was 64. I worked with Cherry long ago in a Sun Sentinel bureau in Pembroke ...


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- Phase 2 data demonstrate sustained improvement in disease activity
through three years of LymphoStat-B (belimumab) therapy - - No increase in adverse events, malignancies, infections or laboratory
abnormalities over time -
ROCKVILLE, Md., June 12 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the presentation of results from a long- term Phase 2 continuation trial showing that LymphoStat-B(R) (belimumab) was associated with sustained improvement in disease activity across multiple clinical measures, decreased frequency of disease flares, potential steroid- sparing activity, and was generally well tolerated through three years on treatment in combination with standard of care in patients with serologically active systemic lupus erythematosus (SLE). The results are the subject of a number of oral and poster presentations today in Paris at the 2008 Congress of the European League Against Rheumatism (EULAR).
(Logo: http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO )
"Based on the results presented at EULAR 2008, the clinical benefit
observed for belimumab at Week 52 of this Phase 2 study appears to be
durable through three years," said Richard Furie, M.D., Chief, Division of
Rheumatology and Allergy-Clinical Immunology, North Shore Long Island
Jewish Health System, Lake Success, NY, and Associate Professor of
Medicine, New York University School of Medicine. "We observe that patients
who crossed over from placebo to belimumab after Week 52 have also shown
improvement across multiple clinical measures. The durability of clinical
effect and the favorable safety p
|SOURCE Human Genome Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved


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Mine sucked. I was way too young and BD and I were watching Big in my bedroom. Yeah...Big, Tom Hanks. Awesome. It was awkward, and when it was over he got up and started wheeling around in my wheelchair I had in my room for my Halloween costume. Nothing special...what so after.
Oh, and the best part, was when he asked "can I stick it in?"
He took my burst of laughter as a yes.
Oy vey.
Your turn!


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An Oak Harbor woman appeared in the Toledo Municipal Court on Friday after Ohio State Highway Patrol troopers arrested her for attempting to convey illegal drugs onto the grounds of the Toledo Correctional Institution.
Troopers charged Ann M. Goode, 42, with attempting to convey suspected marijuana and prescription pills onto the grounds of a correctional facility, a third-degree felony.
Troopers along with Department of Rehabilitation and Corrections investigators were monitoring both Goode and the inmate during a scheduled visit when they observed Goode pass the contraband to the inmate. Goode was arrested and was found to have had in her possession 26 grams of suspected marijuana, two grams of crushed suspected Percocet pills and two-and-half Alprazolam pills.
Goode was incarcerated at the Lucas County Jail. If convicted, she could face up to three years in prison and up to a $7,500 fine.
The Ohio State Highway Patrol investigates criminal activity on state-owned and leased property.


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This Friday will be my last day at 10up, and it's kind of bittersweet like most so-longs.
I'm excited to return to the creative opportunities I have as a freelancer, and exceptionally bummed to be leaving the perfect company of the other designers and friends I've made on the team. There's some incredible talent on that team, as well as hilarious and unrivaled wit, both of which I've gotten accustomed to enjoying on a daily basis.
A couple of people in particular have helped rewire the way I think from just "yes, and!…" to "sure, but why?" (I've learned through trial and error that these people don't enjoy being called out by name, so I'll just use Taylor Dewey, Carl Danley, Tammy Hart and Jake Goldman's initials for now.) The point is, I've been challenged in ways I didn't realize I needed, and grown in ways I didn't think I could. Or didn't think I wanted to. And at times, I fought it pretty hard. (I think every customer service rep I've encountered since has regretted these changes in me, by the way.)
But, you know when it's time.
Toward the end of last year, feeling a little creatively restless, I worked with Kathleen Shannon of Braid Creative. I met Kathleen at Designer Vaca, and knew she was the creative mentor I needed to further kick my ass help me clarify my professional goals. Week after week we spoke, she asked tough questions, and I got to the bottom of where I was meant to be going.
So, what's next. I'll be taking a week or two to focus on a personal side project I've been neglecting, after which I've got some really cool work lined up doing packaging and identity design for some new restaurants, as well as an organic juice line—which I still think must be one of my friends punking me because it's almost too perfect. Pretty much exactly the vision Kathleen and I discussed just before Christmas, as fate would have it. I'll even be spending part of the week at a sweet new co-working space (the owner, a fellow designer, and I have routinely live-texted through Parenthood and The Mindy Project since my first day there, so, yeah).
So there you have it: A return to freelancing, and taking life one day at a time. Equal parts excited and healthy amounts of scared, the basis of most great work.


text: COLLEGE PARK, MD - NOVEMBER 17: US President Barack Obama with his daughters Malia (L) and Sasha (R) in their seats before a college basketball game between the Oregon State Beavers and the Maryland Terrapins on November 17, 2013 at the Comcast Center in College Park, Maryland. (Photo by Mitchell Layton/Getty Images) [ President Obama Against Compensation For College Athletes By NewsTalk 1290 March 23, 2015 President Barack Obama is coming out against compensation for college athletes. Read More|Comment Category: Politics, Sports Tags: barack obama, college Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Career Management System for Alumni
The Career Development Office uses the Career Management System (CMS), powered by Symplicity, to provide the following resources to alumni:
Job Postings
Employers specifically looking for Yale alumni utilize CMS to enter job openings directly online. The job announcements are searchable by job type, practice area, and geographic location. For access, please contact CDO at 203-432-1676.
Career Connections
More than 1,600 alumni members have volunteered to provide career-related advice to alumni. We strongly encourage you to use Career Connections with unusual care: contact members for career-related advice only and not for solicitation, political or commercial purpose; be conservative in the number of members you contact; and finally, contact members using the method of contact that they request. For access, please contact CDO at (203) 432-1692.
We encourage alumni to share their career experiences with members of the Yale Law School community by joining Career Connections today. For alumni who are already members, don't forget to edit your Career Snapshot in CMS when you have new career-related information to share.


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Selena Genevinne Model
Hurst photographerPhotographer Male Nashville, Tennessee, US
My Website: HurstStudios.comMy MM URL: http://www.modelmayhem.com/hurstphotographer
Mayhem # 2657074
About MeHello Model Mayhemers,
My name is Evan. I just turned 30. I currently live in Nashville Tn and my fiancé and I just bought a second home in Joshua Trees California. I have lived and worked mostly in Nashville for the last 9 years or so after moving out of Florida. My background is in tv and Film doing lighting and camera support. I have worked on films such as '42' and 'The Help', I have 3 years on ABC's 'Nashville' and have worked with just about every country musician you can think of.
I have had a camera in my hands for about 5 years now. Taking my knowledge and experience from film and implementing it in my own work. Its all just manipulating light and subjects to create anything your heart desires. Its cool loll
I have been published a few times. That is my main focus right now. I am very interested in working with Designers, Art Directors, and Stylists to create shoots with the ultimate goal of publishing.
Right know a lot of what I do is TF. Collaboration. I am interested in working with people of all skill sets. Experience doesn't matter only makes you better, and that is why we should shoot. Especially if we can get something published. Contact me for anything.
Canon 5D mk III, 85L 1.2 mk II, 24-70L 2.8 mk II, Alien Bee Strobes, Canon Speedlights, Various reflectors, and Light modifiers of all shapes and sizes. My iMac, Lightroom, Photoshop. All that fun stuff.
Selena Genevinne Model
mw2015 Model
SkittlesKi... Model
SHERENE Clothing Designer
Britter_K Model
ktdid1119 Model
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6th Annual Marsh Madness Sandhill Crane Festival
March 6th and 7th
Schedule of Events
Friday, March 6 2015
Venue: Linton Elks
$25 per person Tickets available onine or by mail
6:00PM – 6:45PM Doors open. Music by Brent McPike and Solly Burton.
Cash Bar. soft drinks - Silent auction begins.
6:50PM – 7:00PM Welcome comments – Nyle Riegle
President, Friends of Goose Pond
7:00PM – 7:45PM Buffet dinner line opens. Silent auction continues.
Dinner menu to be determined
7:45PM – 8:15PM Keynote Speaker, Joe Duff of Operation Migration
8:15PM Live Auction, cash bar & soft drinks
9:00PM Silent Auction closes
9:15PM Silent auction winners announced
9:30PM Closing remarks and auction checkout
10:00PM Banquet activities end.
Saturday March 7th
Tickets available at the door. $5 per person or $15 for family of four
Children 3 and under free
Venu: Roy Clark Community Building Humphrey's Park Linton
9:00AM – 3:00PM Art & Craft Fair
7:30AM – 7:00PM Self-guided driving tours (see map)
10:00AM – 3:00PM Birds of prey display (live)
10:00AM -10:45AM Hardy Lake Birds of Prey Program
10:00AM – 3:00PM Wabash Valley Herpetological Society. Live Amphibians and
Reptiles on Display
2:00PM - 2:45PM Hardy Lake Birds of Prey Program
11:00AM & 3:00PM Linton resident and author Suzzane Dickerson will present
readings from her illustrated book Legend of the Whooping
4:00 PM – 5:00 PM Using Aircraft to Establish A Migratory
Whooping Crane Population in Eastern N. America
a presentation by Joe Duff of Operation Migration
Venue: Girl Scout Cabin in Humphreys Park
11:00AM – 11:45AM How Birds Fly: A Look Under the Hood
George Sly
12:00PM – 12:45PM An Owl Pellet Dissection: A Lab for Kids Young and Old
Amy Kearns
1:00PM – 2:00PM Birdscaping: Creating Bird Habitat in Your Backyard.
Sharon Sorenson
Venue: East Cabin in Humphreys Park
7:30AM – 6:30PM Bus Tours of Goose Pond FWA
Refer to bus schedule in this guide
9:00AM – 6:00PM Goose Pond: The Story of a Wetland and Its Neighbors
This award winning documentary by Bill Barnes
will play throughout the day. Free popcorn included.
Venue: West Cabin in Humphreys Park
9:00AM – 3:00PM Kids' Activities, Bird House Construction
Open to kids 12 & under who are accompanied by an adult.
Venue: Goose Pond – Site ad Time TBD
Retriever Demonstrations
Venue: Goose Pond FWA Highway 59 Check-in Stand
9:00AM - 2:00PM Special birding trip for young birders to see Sandhill Cranes and waterfowl. Co-sponsored by the Indiana Young Birders Club of Indiana Audubon Society and the Marsh Madness Sandhill Crane Festival. Led by Advisors and members of the IYBC. For details click on the link below:


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Currently studying 3rd year genetics at Cardiff University while being president of our university's mountaineering club. Only the one alpine season so far but only been climbing since coming to uni. Into my trad climbing over all, its all about the feeling you get when your over gear on a difficult move but successfully make it!
Best Climbing Experience
All are great, but climbing multi-pitch in the Wye Valley on a scortching hot day has been one of the best along with my first leads at Sennen in Cornwall!
The CUMC Road trip to the lakes, done countless amazing routes and seen some awesome crags! And now my first Alpine trip out to the Ecrins Massif for 3 weeks, was an awe inspiring trip with great friends!
Recent Postings
- No posts in last 30 days
Personal Webpage
Interests Outside Climbing
Apart from my uni work, friends, and job not alot! But I think thats more than enough for me for now.
About My Photography
Photography isn't anything particularly special, just doing the best with my mobile phones camera when out and about climbing, love getting good shots with great backdrops, have used a friends SLR several times (Bunchuk/Jamie Maddison) several from his gallery are actually my photos (thief!) plan to get one myself one day when I have the cash.
Photo Gallery
Click to view Eccentric's gallery. (17 photos)
Click to search for photos of climbers called Eccentric.
Click to list photo comments written by me. (2 comments)
I've voted for 64 photos, average vote 4.3.
(46% superb - 42% good - 7% average - 1% poor - 1% rubbish)
Anything Else We Should Know
Im awesome! and modest too, hehe! Just enjoying life.


text:
Originally Posted by Ronald Moravec
My sunny day light exposures were 1/250 at 6.3. Meter or not, this worked every time and I never missed exposure.
What IR film was this? This speed at this aperture seems very fast compared to what most say is the kind of exposures necessary. Handholding would seem to be a problem for most IR users but clearly not at this speed.


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Tier 1 (Exceptional Talent) visa
2. Eligibility
To get a Tier 1 (Exceptional Talent) visa, you need to be endorsed as a leader or emerging leader in:
- science
- engineering
- humanities
- medicine
- digital technology
- the arts
Your application for endorsement is considered by:
- Arts Council England
- British Academy
- Royal Academy of Engineering
- Royal Society
- Tech City UK
Read the eligibility and assessment criteria for your field before you apply.
How to get endorsed
You need to apply for endorsement using 2 forms.
Download and fill in the application for endorsement form and the additional form for your field.
Read the detailed guidance on filling in the application for endorsement form and the additional guidance for applicants in the fields of science, humanities, engineering, medicine and digital technology.
What happens next
If you're successful you'll receive an email from the Home Office with a copy of your endorsement letter. You'll need these for your visa application.
You'll usually get a decision on your endorsement application within 8 weeks.
You won't automatically get a visa if you've been endorsed. If your application is turned down you can request an endorsement review.
You must apply for your visa within 3 months of receiving your letter of endorsement from the Home Office.


text:
Vale S.A. : Vale S.A. : Financial Report 2012 Vale Financial report 2012 Financial Report 2012 ------------------------------------------------------------------------------ This announcement is distributed by Thomson Reuters on behalf of Thomson Reuters clients. The owner of this announcement warrants that: (i) the releases contained herein are protected by copyright and other applicable laws; and (ii) they are solely responsible for the content, accuracy and originality of the information contained therein. Source: Vale S.A. via Thomson Reuters ONE HUG#1681864
Vale S.A. : Vale S.A. : Financial Report 2012
Press spacebar to pause and continue. Press esc to stop.


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1. This guy who doesn't have time to deal with watermelon rind.
2. These dudes who understand the importance of teamwork.
3. This guy who turns cotton candy into an art form.
4. This person who takes "quick turnaround time" very seriously.
5. These ladies in Thailand who put an interesting twist on ice cream.
1. Mash up bananas, strawberries, and chocolate cream on a freezing surface.
2. Spread it.
3. Scrape it.
6. This man who chops scrambled eggs in the most awesome way possible.
10. These dudes who made three large pizzas in record-breaking time.
11. This dude who found a way to peel an apple in three seconds.
12. This man who didn't have a peeler. So he said, "That's OK. I'll just use this GIANT FUCKING KNIFE."
16. This Turkish ice cream vendor who likes to troll his customers just because he can.
17. This guy who turns cucumbers into scrolls.
18. This guy who cracks eggs in mid-air because, you know, he's a badass.
19. This lady who operates faster than you can say "cake."
21. This dude who made 12 breakfast burgers in less than five minutes. He spread six eggs over an iron grill, like an omelette:
He put 12 patties on top of the egg:
He chopped it evenly and served them on buns LIKE A BOSS! TAKE THAT MCDONALD'S!
Preview Your Response
In The News Today
- Takaaki Kajita and Arthur McDonald have won the Nobel Prize in physics for their discovery that neutrinos have mass. ›
- Russia is reportedly preparing to send ground troops to aid Syria's campaign against rebel forces. ›
- Grace Lee Boggs, Detroit activist and civil rights pioneer, has died at the age of 100, according to the Boggs Center. ›


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Category: Human Capital Management
Enhancements to Personnel Action (PA) and Organizational Management (OM) Forms Effective April 27
Managers and Payroll Coordinators,
In response to community feedback, enhancements are being made to the Personnel Action (PA) and Organizational Management (OM) forms to improve overall usability and reporting capabilities. The first set of enhancements will be implemented and effective April 27. These changes are highlighted below. Additional enhancements are scheduled and will be announced in May.
Enhancements to PA Forms:
- "Position Revision" Form Renamed to "Employee Position Update"
The Position Revision form has been renamed to Employee Position Update to reduce confusion by more accurately describing the forms purpose. The effective date label which appeared on the forms has also been renamed to Employee Position Update Effective Date.
- "Percent Time Employed" Input Field Expanded to Include Two Decimals
The Percent Time Employed field now allows for the entry of two additional decimal places. This enhancement improves the calculation of annual salary, merit increases and reporting of hours. As changes are made to the time percentages, the "regular hours" fields will be updated on the relevant PA forms.
- Additional Reason Types Added to Forms – Quick Reference Information Available
A specific "reason" must be selected from a drop-down list when completing a Position Change, Transfer or Employee Position Update form. BUworks has added additional reason types for processing position changes, transfers and employee position updates. Quick reference information, which includes definitions of these reason types as well as guidance on when to use specific reasons, is available by clicking this link.
Enhancements to OM Forms:
- Enhancements to the Budget Tab
The following fields have been added to the Budget tab, Current Year Budget Amount, Recurring Budget Amount and Position Planning No. The Budget office will be maintaining these fields.
- Master Cost Center now appears on "Position Detail" tab
Previously, initiators could not enter a master cost center for a position on the OM form. Only the Budget office could maintain this information on a position. As part of this enhancement, master cost center now appears on the "Position Detail" tab so a user may enter a suggested master cost center. The Budget office has the ability to change the proposed master cost center if required.
If you have any questions please contact the IT Help Center at firstname.lastname@example.com or 617-353-4357.
Shridhar Kulkarni
Director, Human Capital Management
Enhancements to Personnel Action (PA) Forms Effective March 8, 2012
Payroll Coordinators, Readiness Leaders and Power Users —
This update is to inform you that minor changes are being implemented to the Personnel Action forms effective March 8. These enhancements are being made in response to requests from end users to reduce the complexity, and improve usability, of the forms.
Enhancements to Termination Form
- To simplify the Termination form, the following date fields have been removed:
- Last Day Paid
– Last Day Worked
– Paid in Lieu of Work
– Pay Through Date
- The "Date of Action" field has been re-labeled "Termination Date" (which is still considered the last day the employee was employed at Boston University); the "Action Reason" field has been re-labeled "Termination Reason".
- If the employee is monthly-paid, the "Start Date" for the Accrued Vacation Pay will default to the "Termination Date". As always, if the employee is weekly-paid the department will need to execute the amount to be paid through PA61, Infotype 416.
Enhancements to Salary Cost Distribution Form
Many users have requested more visibility on salary cost distributions currently on an employee record. Departments can now view all sets of cost distributions for an employee before they submit a new cost distribution form. You can easily access the salary cost distribution display from a link on the cost distribution form date selection.
If you have any questions on the form enhancements, please contact the IT Help Center at firstname.lastname@example.com or 617-353-4357.
Shridhar Kulkarni
Director, Human Capital Management
Enhancements to OM Position Forms Effective March 1, 2012
As previously communicated, several enhancements are being implemented to the Create/Maintain/Delimit Position forms. These enhancements will be released tomorrow March 1, along with integrated OpenHire functionality.
New Enhancements
- Users can now attach position-relevant documents to OM Position forms.
- Central HR will use information from the OM Position forms to integrate data with OpenHire, the University's applicant tracking system, to streamline the position posting process. Departments are now able to submit an initial draft of the web posting description and requirements for their position.
- Key data fields have either been added, or relabeled, to make the forms easier to use.
- The Temporary Position option has been re-labeled to ensure its intended purpose, which is to identify a position as an overlap when two employees are temporarily sharing the same position.
- To eliminate confusion, the Post Position checkbox is now presented as three radio button options, enabling users to select if the position should be opened for hire, recruitment or neither.
- New data fields, providing such information as hiring manager's name, phone number and email, will support the HR Recruitment process.
Training and Support
- The BUworks Training team is continuing to conduct webinars as well as instructor-led labs conducted on both the Charles River and Medical campuses through Friday, March 9. These training sessions are intended for employees who complete Organization Management (OM) forms today via the Manager Self-Service and Payroll Coordinator tabs on the BUworks Central portal.
- Access Training Manager to view the training schedule and register for an upcoming webinar or lab.
- View or print the updated Quick Reference Guides:
Should you have any questions please contact Jeff Small, Time Management Administrator at 617-358-4817.
If you have any questions on the OM forms, please contact the IT Help Center at firstname.lastname@example.com or 617-353-4357.
OM Form Enhancements Training with Integrated OpenHire Functionality
Payroll Coordinators and Managers–
BUworks will be implementing several enhancements to the Create/Maintain/Delimit Position forms in early March. The BUworks Training team will conduct webinars and instructor-led labs on both the CRC and BUMC campuses. These training sessions are intended for employees who complete Organizational Management (OM) forms today via the Manager Self-Service and Payroll Coordinator tabs on the BUworks Central portal.
What Will Be Covered:
The training sessions will cover:
- Organizational Management form enhancements – changes to the Create Position and Maintain Position Changes tabs
- OpenHire functionality is integrated into the OM forms (i.e., option to post to HR website with position description information). If the candidate is hired through the posting and online application, information will be imported into the Hiring form.
- Relabeling of existing fields and additional new fields for improved usability
- Adding attachments to the create, maintain and delimit position forms
Register Today:
Webinar and lab sessions will cover the same material. Register for one session only. Space is limited.
Note: Please register for one session only.
Webinars: (90 min.)
Register for OM Form Enhancements Webinar
Instructor-led Labs: (2 hours)
Register for OM Form Enhancements Lab (CRC)
Register for OM Form Enhancements Lab (BUMC)
Reference Materials:
Online reference documents will be available when the enhancements are implemented:
- An overview and description of the changes to the OM forms
- Specific, step-by step "quick reference guides" on how to complete the forms
If you have questions regarding the registration process, please contact Victor Botvinnik at 617-358-6850.
2011 W-2 Statements to Mail January 31, 2012
All employees who have been on the University payroll during 2011 will receive a W-2 Wage and Tax Statement listing their 2011 earnings as reported to the Internal Revenue Service. W-2s will be mailed to employee's home addresses (as listed in Employee Self-Service) no later than January 31, 2012.
In the future, we plan to have W-2 statements online and easily accessible through the BUworks Central portal. If you have questions or need assistance on W-2s, please contact BU Payroll at 617-353-2270 or e-mail firstname.lastname@example.com.
Sam Arcidy
Boston University Payroll
BUworks Update: Changes to Leave of Absence (LOA) Form
We will be implementing relatively minor enhancements to the Leave of Absence Form on Wednesday, Jan. 25. The form field specifying the type of leave has been modified to make it easier to indicate leave status. The form changes are illustrated below.
After Jan. 25 changes
If you have any questions on the LOA form changes, please contact Paulomi Joshi at 8-6063 firstname.lastname@example.com.
Shridhar Kulkarni
Director, Human Capital Management
Enhancements to MSS Request Tracking Application
Based on feedback from managers, payroll coordinators, and financial administrators who use the MSS Request Tracking application to monitor the status of HR, Payroll, and financial transactions, BUworks will release enhancements to the MSS Request Tracking application on December 21. These changes, noted below, are designed to improve performance and usability.
Previously, all BUworks transactions that were submitted since July 1, 2011 (go-live) were displayed in a user's tracking window at login. This often resulted in slow response times and cumbersome scrolling for specific, recently submitted transactions.
- Request Tracking will now display all transactions for a rolling 30-day period. Only the transactions initiated in the last 30 days from the user's current login date will be loaded and displayed.
- Users will still have the ability to search for transactions that are older than 30 days by entering a tracking number or by searching by dates and/or request type.
Please note: Open searches with no dates, tracking number, or request type are not recommended, because this may slow down system performance when a user has many historical transactions available.
- Also, ten rows of transactions will be displayed in Request Tracking instead of the five rows that were previously displayed.
If you have questions about these changes, please submit a Help Desk ticket and a BUworks representative will respond as soon as possible.
Scott Forrester
Director, HCM Business Process Support
Weekly Payroll Time Entry Deadlines for Intersession
Timekeepers and Managers: As we approach the holidays and intersession there will be a number of early time entry deadlines. Prior to the early deadlines, managers (and in their absence, timekeepers) must release future time for weekly-paid employees in order for the employee to receive their full week's pay. In SAP time capture employees cannot release future time.
Please refer to the intersession memo and quick reference guide for details on time entry deadlines.
- Time Entry Deadlines For 2011 Intersession – December 6, 2011
- 2011 Intersession Quick Reference Guide – December 6, 2011
Enhancements to Salary Change, Salary Cost Distribution, and Position Revision Forms
Based on input from payroll coordinators, enhancements have been made to improve the process for replacing, changing, and inserting cost distributions without negatively impacting other existing cost distributions. This functionality has been moved into production and can now be used to more easily fix or change incorrect salary cost distributions, both retro-actively and prospectively.
Quick Reference Guides to explain these changes in greater detail can be found on the BUworks website through the following links.
- Completing a Salary Change Form – November 23, 2011
- Completing a Salary Cost Distribution Form – November 23, 2011
- Completing a Position Revision Form - November 23, 2011
Upcoming Weekly Payroll Time Entry Deadlines
Managers and Timekeepers
As we approach the holiday season there will be a number of early payroll deadlines. In SAP, weekly paid employees can enter time in advance but cannot release future time. Prior to these early deadlines, it is important that managers (and in their absence, timekeepers) release future employee time for weekly-paid employees to receive their full week's pay. Please make note of the time entry deadlines and time correction information provided in the document below.
To see TIME ENTRY DEADLINES and CORRECTIONS TO TIME SUBMITTED see Full Post:
Thanksgiving Full Post – November 17, 2011
Thanksgiving Quick Reference Guide – November 17, 2011
If you have any questions please contact Jeff Small, Time Management Administrator at 617-358-4817, email@example.com


text:
Orlando, Florida - United States
Property ID: 5945
Print Page
Kingstown Reef combines warm hospitality with every contemporary resort amenity. Get exercise in two beautiful free-form pools. Kids can also enjoy the youth pool with a refreshing waterfall. Enjoy the convenient fitness room right by the pool, or swing into action on the lighted tennis courts and two adjacent golf courses.Check-in Time: 16:00Check-out Time: 10:00Check-in Days: SaturdayImportant InformationMinimum age check-in is 21.No smoking in units: could result in forfeiture of the unit and/or other penalties.Pet Information: Animals are not permitted; could result in forfeiture of the unit and/or other penalties.Parking Restrictions: Limited parking onsiteCredit card imprint required upon check-in at the resort.Resort cannot honor unit upgrades or moves.Security deposit required upon check-in at the resort.The earliest you should contact the resort is 2 weeks prior to your check-in date.Only the person named on the reservation will be allowed to check-in.Contact the resort in advance to schedule a late arrival: 407/597-2550 during businss hours prior to arrival.Resort requires a credit card deposit of US$100 at check-in.Smoking is not allowed in units.Resort is not suitable for handicapped people, elderly, or people with walking difficulties.Occupancy limits are strictly enforced: could result in forfeiture of the unit and/or other penalties.Fees or deposits are charged for some amenities.Confirmation is required upon check-in at the resort.Mandatory fee: Mandatory Cleaning Fee is 45.00 to 75.00 U.S. dollars.


text:
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SAP HANA Managing Consultant
IBM Chicago, ILJob description: …smarter. The SAP HANA Consultant will be responsible for successful delivery of functional and technical components of Business Intelligence (BI) reporting solutions...
Qlikview Database Developer
Incepture Jacksonville, FLJob description: JOB DESCRIPTIONThis is a full-time position that supports business intelligence activities for the company. This position creates, provides and organizes reporting...
Building Management System Implementation Lead
DISYS Houston, TXJob description: …systems – SCADA• Iconics implementation specifically relating to reporting capabilities• BizViz – Manufacturing intelligence and business...
Interaction and Visual Design Lead
Dell Santa Clara, CAJob description: …synthesize feedback while maintaining ownership of design process * Strong oral and written communication skills * Experience designing SaaS Business Intelligence/Analytics...
Mobile Computing Engineer
White Oak Technologies, Inc. Fort Bragg, NCJob description: …to both our clients and employees through innovation, solid business skills, and dedication to excellent service. As a company…meets...
EVM Scheduler – Maricom
CSC Baltimore, MDJob description: …MARGIN-BOTTOM: 0px">Maricom, a CSC company, is an IT solutions firm, specializing in Data Management, Software Engineering, Business Intelligence solutions,...
Enterprise Architecture Lead – Global Financial Information Systems
Ernst & Young Atlanta, GAJob description: …Program Leadership, effectively and consistently communicating this to key stakeholders. * Pursuing and building relationships across business and...
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sap bi video classes to beginners for those who r seeking career in sap bi/bw contact me @[email protected]
Business Analyst-Datawarehousing-Maine
Randstad Technologies Portland, MEJob description: …MARGIN: 0in 0in 0pt" class=MsoNoSpacing>Looking for two Business Systems Analyst with Business Intelligence, SQL and financial experience...
OBIEE / SSRS Developer
Partners Consulting Services Georgetown, KYJob description: …Georgetown, KYDuration: 5-6 months (extendable) We are looking for an OBIEE Developer (Oracle Business Intelligence Tools) for...