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Wise Care 365 Free
Wise Care 365 provides the best solution to improve your PC's performance. It not only promises a dead easy use but also brings the...
Wise Care 365 provides the best solution to improve your PC's performance. It not only promises a dead easy use but also brings the...
PC sticks are popping up all over. These are tiny devices that are full PCs that can be plugged into any TV or monitor and used securely. We've rounded up a few of the top ones for consideration.
Lenovo has entered the PC stick business with the Ideacentre Stick 300. The tiny stick plugs into any TV or monitor via HDMI to transform it into a Windows PC.
The UK-based charity Raspberry Pi, which hopes to supply schools worldwide with ultra-low-cost computers, has shown off the current version of its $25 computer running Quake 3.The device itself is only about the size of a credit card and is designed to connect to a PC, monitor, or a touchscreen to create a cheap tablet.
Who needs a PC? Someone should produce a "dumb" docking station that you can plug your smartphone into. Connect it to a keyboard, mouse and wide-screen monitor and you are on your way.
Demand for touchscreen devices will perpetuate workplace, too, but only if more applications optimized for tactile use are made available in market, note industry analysts.
The Classroom Spy allows you to monitor live screens of remote computers or show you screen to students. You can take control of a...
The EX90 is designed to allow a remote worker to use a single desktop monitor both as a PC display and for high-definition video conferencing
The household thermostat has always been difficult to program--wasting energy and driving up your utility bill. But ZDNet correspondent Sumi Das explains how new networking technologies will one day connect your thermostat and meter to your PC so you are better able to track, monitor, and analyze the energy usage in your home.
Power Spy software lets you know exactly what people do on a computer while you are away. It secretly logs Facebook, Twitter, keystrokes,...
The household thermostat has always been difficult to program--wasting energy and driving up your utility bill. But ZDNet correspondent Sumi Das explains how new networking technologies will one day connect your thermostat and meter to your PC, so you are better able to track, monitor, and analyze the energy usage in your home.
While a few tweaks such as an in-built wireless receiver for keyboard/mouse and a video input so it could double as a monitor for your laptop would be nice, if you're looking for a cheap all-in-one PC, it's hard to ignore the Vostro 320 as an option.
A year after it introduced its 'zero-watt' monitor, Fujitsu Siemens made the same claim about its new PC. ZDNet UK spoke to the company to find out what it means
HP announced this week it is preloading Novell's SUSE Linux Enterprise Desktop on its Compaq dc5850 Business Desktop PC.The PC, which offers high-end graphics and dual monitor support, debuted in April.
Here's a picture of Kayak, the "PC alternative" for emerging markets that Qualcomm announced yesterday. It looks pretty much the way the company described it: sort of a cross between the Apple Mac Mini--bring your own monitor, keyboard and mouse--and the OLPC's XO laptop with its rabbit-ear antennae.
Can't figure out what to do with your old laptop, tablet PC, monitor, projector, camera, camcorder, server, home audio receiver, mobile phone, car audio system, home electronics device, global positioning satellite receiver, MP3 player, personal digital assistant or game system? (Whew.
Seemingly genuine images of Asus's upcoming all-in-one monitor and PC have appeared on a French blog
Yesterday, I asked for people to share their thoughts via a guest blog on virtualization in Ed Tech. Guest blogger Erik Josowitz provided us with the following (thanks, Erik). Feel free to talk back or submit your own guest blog with some specific experiences or implementation details. Virtualization is great tool but, like any Swiss-Army knife, success with it depends on the task at hand. One of the places that people get into trouble with virtualization is when they try to use out-of-the-box virtual infrastructure with non-technical audiences. Virtualization is a great solution but often is not a complete solution.In education we've frequently seen challenges that look like appropriate places to implement a virtualization solution, only to find that the end-result is not fully usable by the intended audience. One example is providing hands-on lab environments to support application training. Success in the workforce today depends on high-level application skills and there is no better way for students to attain those skills than through hands-on use of the software applications. Many educational institutions provide computer lab environments to help support their student population and provide access to necessary software applications. Many of these lab environments have become the source of IT management problems as they become virus-ridden, get subverted as distribution sites for pirated software or music, or just plain have the normal IT management issues associated with a shared resource in a public environment. For many institutions their student population brings with them their own PCs which solves one problem but creates another. The lab issues diminish but the problems of providing secure access to software (and software licenses) often takes its place.The answer, we've found, is virtual lab management - using virtualization to deliver secure computing environments as a shared resource. Virtual labs allow administrators to serve up a clean and unchangeable environment for each student - in the lab or on their own PC - on-demand. This makes it easy to provide access to applications that students either can't afford individually or that their home PCs cannot support. It makes it simple to track and monitor lab usage and to control the use of resources so that systems are not subverted into file servers. Virtual lab management sits on top of virtualization (from Microsoft or VMware) and tells it what to deliver and to who. It makes it easy for non-technical users to select the types of applications they need from a menu and to gain access to those environments without needing to understand virtualization, networking, hosts systems or anything about how it gets delivered. Best of all, virtual labs make it easy to manage capacity. By scheduling time in the lab environment the shared resource is managed for maximum utilization. If more capacity is needed it is simple to add additional resources to the system. The end-users simply see an increase in availability.Virtualization may not be a panacea for educational institutions, but for a subset of problems, a centralized virtual lab may enable technology administrators to focus their time and attention on enabling learning rather than administering systems.
Region's PC monitor market grows 22.5 percent in the first half of 2007, with sales in LCD monitors leading the way, according to IDC.
Someday soon when you're flying economy class, you'll have a personal in-seat PC with 10.6-inch LCD monitor that will let you work without opening your laptop.
The free tool can be used to inspect and monitor more than 4,200 different PC applications to flag dangerous software vulnerabilities.
Dell has introduced its new Vostro range, aimed at small businesses that require minimal IT support. Here's the full line-up available in Australia at launch.
From Intel Research Labs' open house on June 20: CNET News.com's Tom Krazit talks with Intel Senior Scientist Beverly Harrison about technology she's helping to develop that will monitor the type of exercise someone is getting. The data could be sent to a cell phone or PC from a device worn by the individual.
Classic Steve Jobs disses you can put on your next resignation letter
WikiLeaks: ISPs to hand over copyright infringer details under TPP
For privacy and security, change these iOS 9 settings immediately
Windows 10
Apple quietly adds Bluetooth 4.2 to iPhone 6, iPhone 6 Plus, iPad Air 2


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This is what I am talking about. A fully funded 50,000 meter drilling program:
2013 Drill Program: 50,000m within sedimentary mineralized structural corridor 2013 Drill Program: 50,000 metres Infill drilling •upgrade inferred to indicated ounces •increase drill data density / reduce strip ratio Step out drilling to expand current NI 43-101 pit footprint •test for sub-parallel zones •test for high grade mineralized chutes Board of directors and management team Add additional technical depth Work towards Memorandum of Understanding with First Nations Advance environmental baseline studies - ongoing since 2011
Please take a look at the entire presentation. Thanks to Goldcross for posting the original document:
Looks like mr. Peres and Mr Aubertin are going to be busy this next while!
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The Saint Georges Hotel Restaurant is located in the heart of the famous vineyards of Côte de Nuits.
Pleasant hotel located at 15 km from Geneva centre at the foot of the Sal�ve mountain...
Lovely hotel Reisdence & SPA with an interior heated swimming pool, perfect for leasure or business travellers.
Hotel de Bretagne is in the heart of Lyon. Between the Rhone and the Saone, the main rivers in Lyon,
The Best Western Saphir Lyon 4* is located in the 9th district and just one Metro station from the Lyon's historic city centre.
Stars Lyon-Bron is a modern two-star hotel located in the suburb of Lyon easy accessible by Tram, bus and motorway..
Welcome to H�tel du Simplon, a 2 star hotel with character and charm located in 'presqu�le', the '
The hotel Perrache offers quality service in the true Lyon tradition and is close to the TGV station...
Best Western Le St Maurice, your home in Paris
Ideally situated in a calm street between la porte de Vincenne and la Place de la Nation and 100m from the metro line 1, at 15 minutes from the quarter of le Marais…
Hotel Apogia is only a few minutes away from the Bibliotèque Nationale and from the Airports of Orly and Roissy..
Welcome to Grand Hotel Senia, a small friendly family run hotel 5 mins from Orly Airport.
Find great deals on quality Eckbolshein, France hotels & resorts, or indulge at one of our luxury resorts. Take advantage of the many amenities that can be included with your stay such as in-room internet access, wifi, room service, fitness center, pool, hot tub, steam room, and shuttle services to and from the airport. Browse our Eckbolshein, France hotels and resorts and plan your Eckbolshein, France vacation today!


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The World's Largest Coalition of Nontheists and Nontheist Communities!
Check out the main character. Is this just another example of the terrible damage done by the Christian Ex-Gay movement? To prove my point, look at about 3:21.
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Wonderful balance and sense of harmony here, with rich earthy currant, black cherry, anise, sage, cedar and tarry notes, finishing with ripe tannins and excellent length. 2,460 cases made.Drink Dates: 2000-2010
Professional content appears courtesy of Vinfolio
Deep red-ruby color. Fruit-driven aromas of cassis, red and black cherry, mint, oak spice and tobacco. Lush, dense and smooth; not a huge wine but one with noteworthy balance and concentration. Finishes with very good persistence and nicely ripe tannins.Author: Stephen Tanzer
Professional content appears courtesy of Vinfolio
The 1997 Coach Insignia (77% Cabernet Sauvignon, with the rest Merlot and Cabernet Franc) is powerful, with a seamless personality. The wine is moderately tannic and full-bodied, with loads of chocolatey, black cherry, and cassis fruit.Drink Dates: 2000-2014
Professional content appears courtesy of Vinfolio
199 bottles owned by 78 collectors.
Since its founding in 2003, Vinfolio has brought the rarest and highest-quality wines to the collector market. Located in San Francisco and Napa, we are a company of wine experts who understand and value the importance of wine provenance. Our premium supplier relationships and first-in-class technology help us protect your wine from sourcing through shipping with extraordinary care that only we can provide. Don't trust your fine wine with anything less!Learn More


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Main Content
- Collar: 100% 8.6oz. Polyester flat-knit rib
- Decorated in team colors
- Embroidered NFL patch sewn onto bottom of front collar
- Machine wash cold, hang to dry
- Made in Honduras
- Officially licensed
- Printed name, number, sleeve details, and team wordmarks and logos
- Reebok jock tag applied above left hem
- White: 100% 5oz. Polyester diamond-back mesh body/yoke/sleeves and polyester dazzle side inserts
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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Wedding decorations, party supplies, home décor & craft supplies at 20-70% off. Save On Crafts brings you classic and trending fashions.
With its rich, luxurious color, the Purple Silk Ribbon will bring a lavish look to your wrapped bouquets or decorations. This deep violet strand has been custom dyed, and features varying saturation of purple and indigo. For a regal event, wrap this ribbon around the stems of your white rose bouquet, and use jewel-topped ribbons to keep it in place. This ribbon is 1.5" wide and 38 yards long.


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Phosphodiesterase Inhibitors
Series Editor:
- Clive Page, King's College London, U.K.
- Christian Schudt, Byk Gulden Pharmaceuticals, Konstan, Germany
- Gordon Dent, Kraankenhaus Grobhansdorf, Zentrum fur Pneumologie und Thoraxchirurgie, Grobhansdorf, Germany
- Klaus Rabe, Kraankenhaus Grobhansdorf, Zentrum fur Pneumologie und Thoraxchirurgie, Grobhansdorf, Germany
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.View full description
Research level pharmacologists, immunologists, and cell biologists; as a reference text in this area for those involved in degree-level teaching. Pharmaceutical companies.
Book information
- Published: August 1996
- Imprint: ACADEMIC PRESS


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The old Southern preacher had walked through many airport security gates using his cherry-wood cane and was surprised -- especially years before 9/11 -- when a guard ordered him to send it through the X-ray scanner.
One radical old baptist patriarch
After that rite, the Rev. Will Campbell asked the guard to bring him the cane. The guard, somewhat miffed, asked if he could walk through the scanner without it. The preacher, somewhat vexed, said that was a question for his doctor.
Facing a nervous crowd, the guard ordered Campbell to walk through the gate. So the famous civil-rights activist -- the only white leader the Rev. Martin Luther King Jr. invited to the first Southern Christian Leadership Conference meeting -- got down on the floor and crawled through. Then he retrieved his cane.
Campbell admitted, when telling this parable to Baptist progressives in 1994, that he then gave the cane a "sassy little twirl." His wife asked: "Why do you do things like that?"
"Because I'm a Baptist! I come from a long line of hell-raisers," said Campbell. "I was taught that I wasn't a robot -- that I was a human being with a mind, capable of reason, entitled to read any book, including the Bible, and interpret it according to the ability of the mind I was given. That's why I do things like that."
The key, he said, is to ask what happened to all the Baptists who kept clashing with authority figures in the past. Where are the Baptists who were willing to be "tied on ladders and pushed into burning brush heaps because they believed in and practiced freedom of conscience," who "were so opposed to the death penalty they wouldn't serve on juries" and who "would not go to war, any war, for church or state?... Where are they now?"
Campbell, who died last month at the age of 88, was a complex activist and writer who made lots of people mad for lots of reasons. Raised in rural Mississippi, he thrived at Yale Divinity School and failed as a small-town pastor. He accompanied the Freedom Riders in 1961 and marched in Birmingham in 1963. He tried to avoid reporters, but was tight with country-music rebels like Johnny Cash and Waylon Jennings. He opposed both abortion and the death penalty and, late in life, backed gay rights.
The self-proclaimed "bootleg Baptist" spent his life preaching forgiveness and reconciliation, yet also called religious conservatives "ecclesiastical highwaymen" who were "espousing a course that is a rollercoaster to a fascist theocracy." Pushed to summarize his theology, he stated: "We're all bastards, but God loves us anyway."
Continue reading this story on the...


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Wild Mushroom and Peas Parmesan Rice
4 servings
- 1/2 ounce dried wild mushrooms
- 1 cup hot water
- 2 tablespoons butter
- 3 cups cooked long grain rice
- 1/4 cup frozen petite peas, thawed
- 1/2 cup grated Parmesan
Place the mushrooms in 2-quart saucepan. Pour the water over the mushrooms; let stand 20 minutes, or until soft. Drain the mushrooms and coarsely chop.
Melt the butter in large skillet over medium heat. Add the rice, mushrooms and peas. Stir until heated through. Add the cheese; toss well.
Recipe reprinted by permission of USA Rice Federation. All rights reserved.
RecID 11002
nutrition information per serving
281 calories; 10g total fat; 26mg cholesterol; 315mg sodium; 38g carbohydrates; 1g fiber; 9g protein
These nutrition facts are calculated according to the ingredients listed in this recipe. Any substitutions will change these facts. Although we strive for accuracy, please note that food manufacturers occasionally change their food formulas, which could affect the calculations as shown.
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Lighting & Decor near bonita springs,fl
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Island Events11 Reviews
Sanibel, FL | 239-565-0650
Island Events, LLC offers rental equipment for parties, weddings and other events - from tables, chiavari chairs and pews to market/cafe...(more)
We rent LED par can's, perfect for decorative room lighting. Super easy to set-up and use! Low power consumption and they stay cool all night. ...(more)
Sweet Southern Charm23 Reviews
Vintage Rentals & Event Styling
Fort Myers, FL | 239-872-5477
Sweet Southern Charm is vintage rental company made up of two small town chicks and an incredible collection of rustic, vintage, shabby chic...(more)
Z Wedding Arches
Hand Blown Crystal Glass with Copper Frames
Fort Myers, FL & Parkersburg WV | 215-680-4707
Our Love for Nature is the Inspiration for the Wedding Arches and Bouquets that will make the "Special Day" Memorable for a Lifetime!!! I would...(more)


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Available Models Compare All For the ultimate experience
XPS 12 Ultrabook™
This touch-enabled 12" convertible laptop combines the fun of a Windows 8 Pro touch tablet with the power and productivity of an Ultrabook™.
Work at full speed with the faster new XPS 13 Ultrabook™, Inspired by Intel®. Expect stunning clarity on the full HD display, now with an optional touch screen.
New XPS 13 Laptop with infinity display
The XPS 13 isn't just the smallest 13-inch laptop on the planet, it also has the world's first virtually borderless infinity display with touch.
33,7cm (13,3") | 2,8lbs


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Team Building
With such a wealth of indoor and outdoor space available, it is easy to appreciate why Knowsley Hall is quite so popular for team building events. You can use larger rooms alongside smaller ones for break out areas, then combine the indoor space with the gardens, grounds and estate at large. We also have a wide range of additional facilities which can add that extra dimension to your day.
Knowsley Hall has teamed up with Segway Events to offer a fantastic team building day taking place within the grounds of the 2,500 acres of private walled estate. Enjoy the fun of a Segway as you take part in a variety of Segway Games. Split into groups, your team will tackle all of the four Segway Games which can include a Segway Obstacle Course, Segway Frisbee Golf, Segway Relay and Segway Splash as they compete against each other in an exciting Segway tournament. As easy to use machines, Segways can be enjoyed by people of all ages and abilities and are perfect for any workforce, with the speed of the Segway being controlled by the user's weight, meaning that everyone can get involved and enjoy the experience.
Click here to view the video
Call the events team to discuss what packages we can offer on 0151 489 4827 or email email@example.com
Knowsley Safari private tours
You can head off in a 4x4 with one of our park rangers and see the animals in authentic safari style.
High Ropes
Did you know Knowsley is home to the world's biggest high ropes adventure course? Incredibly popular for team building days, this multi-level Aerial adventure offers up amazing bird's eye views of the Safari Park whilst really getting the adrenaline pumping.
Bushcraft School
If you're looking for something different to deliver great team building skills then look no further that the Bushcraft school based at Fishbrook Wood at Knowsley Safari run by the team at Komaru Outdoors.
Essentially, bushcraft teaches people to survive and thrive in the natural environment. It helps people develop self-confidence as the use of tools and fire making give people a strong sense of achievement and self reliance. Activities include: survival planning; resource management; fire lighting; shelter building; finding and purifying water; natural navigation and command task exercises.
For details on the bushcraft courses visit the Komaru website at www.komaru.co.uk/activities/team-building
Thank you all for hosting us at Knowsley Hall yesterday. We had some of the highest feedback scorings from our guests that I have ever seen on an Audi event of this type, so thank you!
Natalie Heath, Director
Contact Us
If you would like to check availability, arrange a viewing or request a brochure please fill in your email address below


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Finding underscores need for studies in people, not just animals, expert stresses
WEDNESDAY, Feb. 4 (HealthDay News) -- In a rude reminder that medicine is not yet an exact science, a Dutch study has found that adding a fourth anti-cancer drug to a three-medication treatment actually makes things worse for people with advanced colorectal cancer.
"The lesson is that there may be negative interactions between those inhibitors that may be detrimental to those patients, even when animal studies show benefits," said Dr. Cornelis J.A. Punt, a professor of medical oncology at Radboud University Nijmegen Medical Center in the Netherlands and lead author of a report in the Feb. 5 issue of the New England Journal of Medicine.
That lesson applies to proposed new treatments of all forms of cancer, Punt said. "A lot of new drugs are being developed that work through all sorts of new pathways," he said. "You should carefully design your studies of them before you use them in general practice."
The study of 755 people whose colorectal cancers had spread to other parts of the body was done because not only animal studies but two smaller human trials had found benefits from adding the antibody cetuximab (Erbitux) to a standard three-drug regimen of bevacizumab (Avastin), oxaliplatin (Eloxatin) and capecitabine (Xeloda), Punt said.
Each drug works in a different way. Capecitabine and oxaliplatin kill cancer cells directly, whereas bevacizumab inhibits vascular endothelial growth factor, a natural molecule that promotes cell division. Cetuximab inhibits the activity of another molecule, epidermal growth factor.
Yet the average survival time for people in the trial who got the four-drug combination was 9.4 months, compared with 10.7 months for those given the three-medication regimen. Also, adverse drug reactions were more frequent in those given the four drugs.
The reason for the negative results
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Hi there,
Recently I change my theme to a new one that is not widget-aware. I like the new theme so much but I still having some problems with it.
First question is: is there any easy way that may help me to make it widget-ware?
ps: I read the instructions wordpress suggest but I could not do it.
Second: I edit my sidebar on Sidebar.php file and it is fine, but the problem is, there still two widgets "not really widgets", that still appear even I did not find there code, they are the "Links" and the "Meta". I need to delete "Meta" and keep the Links.
here is my website:
Can anybody here help me.
Thank you for your time.


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IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards,
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Agent software is a topic of growing interest to users and developers in the computer industry. Already, agents and wizards help users automate tasks such as editing and searching for information. But just as we expect human assistants to learn as we work with them, we will also come to expect our computer agents to learn from us. This paper explores the idea of an instructible agent that can learn both from examples and from advice. To understand design issues and languages for human-agent communication, we first describe an experiment that simulates the behavior of such an agent. Then we describe some implemented and ongoing instructible agent projects in text and graphic editing, World Wide Web browsing, and virtual reality. Finally, we analyze the trade-offs involved in agent software and argue that instructible agents represent a "sweet spot" in the trade-off between convenience and control.
Note: The Institute of Electrical and Electronics Engineers, Incorporated is distributing this Article with permission of the International Business Machines Corporation (IBM) who is the exclusive owner. The recipient of this Article may not assign, sublicense, lease, rent or otherwise transfer, reproduce, prepare derivative works, publicly display or perform, or distribute the Article.
A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.© Copyright 2015 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


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Research Topics
Genomes and Genes
Gene Symbol: GJB2
Description: gap junction protein, beta 2, 26kDa
Alias: CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK, connexin 26, gap junction beta-2 protein, gap junction protein beta 2
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications252 found, 100 shown here
- GJB2 mutations and degree of hearing loss: a multicenter studyRikkert L Snoeckx
Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
Am J Hum Genet 77:945-57. 2005..Despite extraordinary genetic heterogeneity, mutations in one gene, GJB2, which encodes the connexin 26 protein and is involved in inner ear homeostasis, are found in up to 50% of patients with autosomal recessive ..
- Carrier frequency of GJB2 (connexin-26) mutations causing inherited deafness in the Korean populationSung Hee Han
Division of Molecular Genetics, Department of Laboratory Medicine, Seoul Clinical Laboratories, Seoul Medical Science Institute, 7 14, Dongbingo dong, Yongsan gu, Seoul, South Korea
J Hum Genet 53:1022-8. 2008Mutations in the GJB2 gene are associated with hereditary hearing loss. Although most studies of GJB2 mutations have dealt with hearing-impaired patients, there are few reports of the frequency of these mutations in the general population...
- Structure of the connexin 26 gap junction channel at 3.5 A resolutionShoji Maeda
Institute for Protein Research, Osaka University, OLABB, 6 2 3, Furuedai, Suita, Osaka 565 0874, Japan
Nature 458:597-602. 2009..Here we report the crystal structure of the gap junction channel formed by human connexin 26 (Cx26, also known as GJB2) at 3...
- Clinical features of patients with GJB2 (connexin 26) mutations: severity of hearing loss is correlated with genotypes and protein expression patternsTomohiro Oguchi
Department of Otorhinolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
J Hum Genet 50:76-83. 2005Mutations in the GJB2 (connexin 26, Cx26) gene are the major cause of nonsyndromic hearing impairment in many populations...
- The contribution of GJB2 mutations to slight or mild hearing loss in Australian elementary school childrenH H M Dahl
Genetic Hearing Research, Murdoch Childrens Research Institute and Department of Paediatrics Melbourne University, Royal Children s Hospital, Melbourne, Victoria, Australia
J Med Genet 43:850-5. 2006..We report the first systematic genetic analysis of the GJB2 gene in a population-derived sample of children with slight/mild bilateral SNHL.
- A large cohort study of GJB2 mutations in Japanese hearing loss patientsK Tsukada
Department of Otorhinolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Clin Genet 78:464-70. 2010b>GJB2 is the gene most frequently associated with hereditary hearing loss, and the GJB2 mutation spectrums vary among different ethnic groups...
- A novel DFNB1 deletion allele supports the existence of a distant cis-regulatory region that controls GJB2 and GJB6 expressionE Wilch
Genetics Program, Michigan State University, East Lansing, MI 48824, USA
Clin Genet 78:267-74. 2010..were found to be homozygous for the common 35delG mutation of GJB2, the gene encoding the gap junction protein Connexin 26. Surprisingly, four additional family members with bilateral profound SNHL carried only a single 35delG ..
- Connexin 26 mutations in hereditary non-syndromic sensorineural deafnessD P Kelsell
Academic Department of Dermatology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
Nature 387:80-3. 1997..of autosomal dominant deafness and have identified a mutation in the gene encoding the gap-junction protein connexin 26 (Cx26) that segregates with the profound deafness in the family...
- The digenic hypothesis unraveled: the GJB6 del(GJB6-D13S1830) mutation causes allele-specific loss of GJB2 expression in cisJuan Rodriguez-Paris
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Biochem Biophys Res Commun 389:354-9. 2009b>Connexin 26 and connexin 30 are the major connexins expressed in the cochlea, where they are co-localized and form heteromeric gap junctions...
- SLC26A4 gene is frequently involved in nonsyndromic hearing impairment with enlarged vestibular aqueduct in Caucasian populationsSebastien Albert
Service d ORL et de Chirurgie Cervico faciale, Hopital d Enfants Armand Trousseau, AP HP, Paris, France
Eur J Hum Genet 14:773-9. 2006..SLC26A4 could be the second most frequent gene implicated in nonsyndromic deafness after GJB2, in this Caucasian population.
- High prevalence of V37I genetic variant in the connexin-26 (GJB2) gene among non-syndromic hearing-impaired and control Thai individualsD Wattanasirichaigoon
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Clin Genet 66:452-60. 2004..Several previous studies have demonstrated that mutations of connexin 26 (Cx26 or GJB2) are responsible for most cases of the recessive non-syndromic sensorineural hearing loss (NSSHL)...
- A deletion mutation in GJB6 cooperating with a GJB2 mutation in trans in non-syndromic deafness: A novel founder mutation in Ashkenazi JewsI Lerer
Department of Human Genetic, Hadassah Hebrew University Hospital and Medical School, Jerusalem, Israel
Hum Mutat 18:460. 2001..could be due to a digenic mode of inheritance of GJB2 and GJB6 genes that encode two different connexins; connexin 26 and connexin 30, or it may abolish control elements that are important in the expression of the GJB2 gene in ..
- Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in ChinaYongyi Yuan
Department of Otolaryngology, PLA General Hospital, Beijing, PR China
J Transl Med 7:79. 2009..To provide appropriate genetic testing and counseling to families, we performed a comprehensive investigation of the molecular etiology of nonsyndromic deafness in two typical areas from northern and southern China...
- Novel mutations in the connexin 26 gene (GJB2) responsible for childhood deafness in the Japanese populationT Kudo
Department of Otorhinolaryngology, Tohoku University School of Medicine, Sendai, Japan
Am J Med Genet 90:141-5. 2000Mutations in the connexin 26 gene (GJB2), which encodes a gap-junction protein and is expressed in the inner ear, have been shown to be responsible for a major part of nonsyndromic hereditary prelingual (early-childhood) deafness in ..
- Prelingual deafness: high prevalence of a 30delG mutation in the connexin 26 geneF Denoyelle
Unité de Génétique de Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, Paris, France
Hum Mol Genet 6:2173-7. 1997..For two of them, DFNB1 and DFNB2, the genes responsible have been characterized; they encode connexin 26 and myosin VIIA, respectively...
- A common founder for the 35delG GJB2 gene mutation in connexin 26 hearing impairmentL Van Laer
Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
J Med Genet 38:515-8. 2001..severe to profound hearing impairment result from mutations in a single gene, GJB2, that encodes the protein connexin 26. One mutation of this gene, the 35delG allele, is particularly common in white populations...
- Clinical significance of the expression of connexin26 in colorectal cancerShinya Nomura
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 5 7 Asahimachi Abeno ku, Osaka 545 8585, Japan
J Exp Clin Cancer Res 29:79. 2010Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene...
- Connexin26 gene ( GJB2): prevalence of mutations in the Chinese populationYuhe Liu
Department of Otolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing 100034, China
J Hum Genet 47:688-90. 2002The connexin26 gene ( GJB2) has been shown to be responsible for DFNB1 and DFNA3 (Autosomal Recessive Hereditary Nonsyndromic Deafness Locus 1 and Autosomal Dominant Hereditary Nonsyndromic Deafness Locus 3)...
- GJB2 mutations in Mongolia: complex alleles, low frequency, and reduced fitness of the deafMustafa Tekin
The Dr John T Macdonald Foundation Department of Human Genetics, University of Miami, Leonard M Miller School of Medicine, Miami, Florida 33136, USA
Ann Hum Genet 74:155-64. 2010..V27I;E114G] disturbs the gap junction function of Cx26, the equal distribution of this complex allele in both deaf probands and hearing controls makes it a less likely ..
- A large deletion including most of GJB6 in recessive non syndromic deafness: a digenic effect?Nathalie Pallares-Ruiz
Laboratoire de Genetique Moleculaire, 34093 Montpellier Cedex, France
Eur J Hum Genet 10:72-6. 2002..Mutations in the GJB2 gene (connexin 26) account for more than 50% of the recessive non syndromic deafness (DFNB1) among 30 loci...
- A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triadJay R Montgomery
USN, National Naval Medical Center, Bethesda, Maryland 20889, USA
J Am Acad Dermatol 51:377-82. 2004..mutation (C119T) in the gap junction beta2 gene that substitutes a valine for alanine at codon 40 (A40V) in the connexin 26 protein...
- Connexin 26 35delG does not represent a mutational hotspotCaryn R Rothrock
Department of Microbiology and Molecular Genetics, Michigan State University, 5163 Biomedical and Physical Sciences Building, East Lansing, Michigan 48824 4320, USA
Hum Genet 113:18-23. 2003..Mutations in the gap junction gene GJB2 account for a high proportion of recessive NSHI. The GJB2 gene encodes connexin 26, which forms plasma membrane channels between cochlear cells...
- Connexin-26 mutations in deafness and skin diseaseJack R Lee
Department of Physiology and Biophysics, Stony Brook University Medical Center, Stony Brook, New York 11794 8661, USA
Expert Rev Mol Med 11:e35. 2009..Mutations in connexin genes cause a variety of human diseases. For example, mutations in GJB2, the gene encoding connexin-26 (Cx26), are not only a major cause of nonsyndromic deafness, but also cause ..
- Evidence of a founder effect for the 235delC mutation of GJB2 (connexin 26) in east AsiansDenise Yan
Department of Otolaryngology, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
Hum Genet 114:44-50. 2003Mutations in the GJB2 gene encoding connexin 26 (Cx26) are a major cause of autosomal recessive and sporadic cases of congenital deafness in most populations...
- Molecular analysis of the GJB2, GJB6 and SLC26A4 genes in Korean deafness patientsK Y Lee
Department of Otolaryngology, College of Medicine, Kyungpook National University, Deagu 702 701, Republic of Korea
Int J Pediatr Otorhinolaryngol 72:1301-9. 2008Mutations in the GJB2, GJB6 and SLC26A4 genes are a frequent cause of hearing loss in a number of populations. However, little is known about the genetic causes of hearing loss in the Korean population.
- Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndromeGabriele Richard
Department of Dermatology and Cutaneous Biology and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Hum Genet 70:1341-8. 2002..leading to substitution of conserved residues in the cytoplasmic amino terminus or first extracellular domain of Cx26. One of these mutations was detected in six unrelated sporadic case subjects and also segregated in one family with ..
- Effectiveness of sequencing connexin 26 (GJB2) in cases of familial or sporadic childhood deafness referred for molecular diagnostic testingBai Lin Wu
Department of Laboratory Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
Genet Med 4:279-88. 2002..loss is a common congenital disorder that is frequently associated with mutations in the GJB2 gene encoding the connexin 26 protein (Cx26)...
- Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibuleAtsunori Oshima
Department of Biophysics, Faculty of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
Proc Natl Acad Sci U S A 104:10034-9. 2007..Connexin26 (Cx26) is the second smallest member of the gap junction protein family, and mutations in Cx26 cause certain hereditary ..
- Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytesJack R Lee
Department of Physiology and Biophysics, Stony Brook University Medical Center, Stony Brook, New York 11794 8661, USA
J Invest Dermatol 129:870-8. 2009Mutations in the GJB2 gene-encoding connexin 26 (Cx26) have been linked to skin disorders and genetic deafness. However, the severity and type of the skin disorders caused by Cx26 mutations are heterogeneous...
- Mutations in GJB2, GJB6, and mitochondrial DNA are rare in African American and Caribbean Hispanic individuals with hearing impairmentJoy Samanich
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Am J Med Genet A 143:830-8. 2007..Approximately half result from mutations in the connexin 26 (Cx26) gene, GJB2, in Caucasian populations...
- A novel N14Y mutation in Connexin26 in keratitis-ichthyosis-deafness syndrome: analyses of altered gap junctional communication and molecular structure of N terminus of mutated Connexin26Ken Arita
Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
Am J Pathol 169:416-23. 2006..The N-terminal 21 amino acids of Cx26 are located at the cytoplasmic side of the channel pore and are thought to be essential for the regulation of ..
- High frequency of 35delG GJB2 mutation and absence of del(GJB6-D13S1830) in Greek Cypriot patients with nonsyndromic hearing lossVassos Neocleous
Department of Molecular Genetics, The Cyprus Institute of Neurology and Genetics, 1683 Nicosia, Cyprus
Genet Test 10:285-9. 2006Mutations in the GJB2 (Connexin 26) gene are responsible for more than half of all cases of prelingual, recessive, inherited, nonsyndromic deafness in Europe...
- Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancerKoji Ezumi
Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Yamada oka, Suita City, Osaka, Japan
Clin Cancer Res 14:677-84. 2008b>Connexin 26 (Cx26) is one of the gap junction-forming family members classically considered to be tumor suppressors...
- Molecular analysis of connexin26 asparagine14 mutations associated with syndromic skin phenotypesEugene A de Zwart-Storm
Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands
Exp Dermatol 20:408-12. 2011..gap junction protein, cause a wide variety of skin disorders including keratitis-ichthyosis-deafness syndrome (KID). We previously delineated a phenotype distinct from KID, hypotrichosis-deafness syndrome, caused by the mutation p...
- GJB2, SLC26A4 and mitochondrial DNA A1555G mutations in prelingual deafness in Northern Chinese subjectsYu Fen Guo
Department of Otolaryngology Head and Neck Surgery, Second Hospital of Lanzhou University, Lanzhou, China
Acta Otolaryngol 128:297-303. 2008..in Northern Chinese patients can be detected at younger ages by genetic testing of three common hearing loss genes (GJB2, SLC26A4 and mtDNA A1555G), and thus, early intervention measures could be undertaken to help them in language ..
- Connexin26 deafness associated mutations show altered permeability to large cationic moleculesGulistan Mese
Graduate Program in Genetics, State University of New York, Stony Brook, New York 11794 8661, USA
Am J Physiol Cell Physiol 295:C966-74. 2008Intercellular communication is important for cochlear homeostasis because connexin26 (Cx26) mutations are the leading cause of hereditary deafness...
- Strong linkage disequilibrium for the frequent GJB2 35delG mutation in the Greek populationHaris Kokotas
Department of Genetics, Institute of Child Health, Athens, Greece
Am J Med Genet A 146:2879-84. 2008..severe to profound hearing impairment cases result from mutations in a single gene, GJB2, that encodes the connexin 26 protein...
- Connexin-26-associated deafness: phenotypic variability and progression of hearing lossDylan K Chan
Department of Otolaryngology Head and Neck Surgery, Lucille Packard Children s Hospital, Stanford University Hospital and Clinics, Stanford, California 94305, USA
Genet Med 12:174-81. 2010To evaluate genotype-phenotype correlation over time for a cohort of children with connexin-26 (GJB2)-associated autosomal recessive hearing loss.
- A novel hearing-loss-related mutation occurring in the GJB2 basal promoterT D Matos
J Med Genet 44:721-5. 2007Mutations in the GJB2 gene are a major cause of non-syndromic recessive hearing loss in many countries...
- GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairmentPu Dai
Department of Otolaryngology and Genetic Testing Center for Deafness, Chinese PLA General Hospital, Beijing, PR China
J Transl Med 7:26. 2009Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups.
- Genetics of congenital deafness in the Palestinian population: multiple connexin 26 alleles with shared origins in the Middle EastHashem Shahin
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel
Hum Genet 110:284-9. 2002..48 independently ascertained probands with non-syndromic hearing loss were evaluated for mutations in the connexin 26 gene. Of the 48 deaf probands, 11 (23%) were homozygous or compound heterozygous for mutations in GJB2...
- High prevalence of the connexin 26 (GJB2) mutation in Chinese cochlear implant recipientsDongye Chen
Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
ORL J Otorhinolaryngol Relat Spec 71:212-5. 2009The GJB2 gene, mapping to chromosome 13q12, encodes a gap junction protein, connexin 26, and is responsible for certain forms of congenital deafness, such as DFNB1 and DFNA3...
- Dandy-Walker malformation in patients with KID syndrome associated with a heterozygote mutation (p.Asp50Asn) in the GJB2 gene encoding connexin 26Ingo Todt
Department of Otolaryngology, Unfallkrankenhaus Berlin, Charite Medical School, Berlin, Germany
Clin Genet 76:404-8. 2009..Most cases are due to mutations in the GJB2 gene encoding connexin 26. The Dandy-Walker malformation (DWM) is a developmental anomaly of the midline of the cerebellum with complete ..
- A novel missense mutation in the second extracellular domain of GJB2, p.Ser183Phe, causes a syndrome of focal palmoplantar keratoderma with deafnessEugene A de Zwart-Storm
Department of Dermatology, University Medical Center Maastricht, Maastricht, The Netherlands
Am J Pathol 173:1113-9. 2008..In the skin, connexins are involved in the regulation of epidermal growth and differentiation. GJB2 encodes connexin26, which is an important skin-expressed gap junction protein...
- GJB2 and mitochondrial A1555G gene mutations in nonsyndromic profound hearing loss and carrier frequencies in healthy individualsElif Baysal
Department of Otolaryngology, Faculty of Medicine, Gazi University, TR 06510 Besevler, Ankara, Turkey
J Genet 87:53-7. 2008This study aimed to assess mutations in GJB2 gene (connexin 26), as well as A1555G mitochondrial mutation in both the patients with profound genetic nonsyndromic hearing loss and healthy controls...
- Low incidence of GJB2, GJB6 and mitochondrial DNA mutations in North Indian patients with non-syndromic hearing impairmentSeema Bhalla
Department of Otolaryngology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Biochem Biophys Res Commun 385:445-8. 2009Mutations at the DFNB1 locus which encode connexin 26 (CX26) and connexin 30 (CX30) proteins, respectively, are main cause for sporadic and familial non-syndromic hearing impairment (NSHI) in many populations...
- Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomasXiaoli Liu
Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
Int J Mol Med 25:709-16. 2010b>Connexin 26 (Cx26), one of the gap junction-forming family members, is more controversial than other members, as a tumor suppressor...
- GJB2 and mitochondrial DNA 1555A>G mutations in students with hearing loss in the Hubei Province of ChinaGuanming Chen
Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Int J Pediatr Otorhinolaryngol 75:1156-9. 2011The GJB2 and MTRNR1 1555A>G mutations are the prevalent causes of hearing loss worldwide. However, the mutation profiles of the two genes are dependent on the ethnic or geographic origins...
- Infant hearing loss and connexin testing in a diverse populationLisa A Schimmenti
Department of Pediatrics, Institute of Human Genetics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Genet Med 10:517-24. 2008..This is the first study to differentiate infants with and without connexin-related hearing loss...
- Overexpression of connexin 26 in carcinoma of the pancreasNaganori Kyo
Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
Oncol Rep 19:627-31. 2008Contrary to the previously purported role of gap junction (GJ) associated-protein connexin 26 (Cx26) as a tumor suppressor, increased expression of Cx26 has recently been demonstrated in several human malignancies...
- Impact of consanguineous marriages in GJB2-related hearing loss in the Iranian population: a report of a novel variantNejat Mahdieh
Kawsar Human Genetic Research Center, Tehran, Iran
Genet Test Mol Biomarkers 15:489-93. 2011Mutations in GJB2 and GJB6 genes are the main causes of autosomal recessive nonsyndromic hearing loss (ARNSHL) in many populations...
- Congenital deafness: high prevalence of a V37I mutation in the GJB2 gene among deaf school children in Alor SetarB H I Ruszymah
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur
Med J Malaysia 60:269-74. 2005Twenty percent of all childhood deafness is due to mutations in the GJB2 gene (Connexin 26). The aim of our study was to determine the prevalence and spectrum of GJB2 mutations in childhood deafness in Malaysia...
- Are GJB2 mutations an aggravating factor in the phenotypic expression of mitochondrial non-syndromic deafness?Haris Kokotas
Department of Genetics, Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
J Hum Genet 55:265-9. 2010..Here we summarize evidence regarding modifying genes, and we discuss the effect of the coexistence of mitochondrial and GJB2 mutations in families reported to date.
- The 35delG mutation in the connexin 26 gene (GJB2) associated with congenital deafness: European carrier frequencies and evidence for its origin in ancient GreeceGérard Lucotte
Institute of Molecular Anthropology, 75005 Paris, France
Genet Test 9:20-5. 2005The 35delG mutation in the connexin 26 gene (GJB2) at the DFNB1 locus represents the most common mutation in Caucasian patients with genetic sensorineural deafness...
- Mutation analysis of familial GJB2-related deafness in Iranian Azeri Turkish patientsMortaza Bonyadi
Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran
Genet Test Mol Biomarkers 13:689-92. 2009Mutations in the GJB2 gene-encoding connexin 26 protein are the main cause for autosomal recessive nonsyndromic hearing loss worldwide...
- High prevalence in the Greek population of the 35delG mutation in the connexin 26 gene causing prelingual deafnessT Antoniadi
Clin Genet 55:381-2. 1999
- Carrier frequencies of mutations/polymorphisms in the connexin 26 gene (GJB2) in the Moroccan populationOmar Abidi
Laboratory of Human Genetics, Department of Scientific Research, Pasteur Institute, Casablanca, Morocco
Genet Test 12:569-74. 2008Mutations in the Connexin 26 gene (GJB2/Cx26) are responsible for more than half of all cases of prelingual nonsyndromic recessive deafness in Caucasians...
- Detection of epidermal thickening in GJB2 carriers with epidermal USPierpaolo Guastalla
Radiology Unit, Institute of Child Health, Istituto di Ricovero e Cura a Carattere Scientifico, Burlo Garofolo Hospital, Trieste, Italy
Radiology 251:280-6. 2009..thickness by using skin ultrasonography (US) in a series of healthy control subjects and obligate carriers for the worldwide most frequent form of congenital hearing loss owing to the mutated alleles of the connexin 26 gene (GJB2).
- Spectrum of GJB2 mutations in a cohort of nonsyndromic hearing loss cases from the Kingdom of Saudi ArabiaMohammed H Al-Qahtani
Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
Genet Test Mol Biomarkers 14:79-83. 2010..the task of unraveling the genetic causes of hearing loss in Saudi Arabia, starting with identifying the GJB2/DFNB1 mutation spectrum in a cohort of unrelated individuals suffering from mild to profound NSHL...
- Connexin 26 gene mutations in congenitally deaf children: pitfalls for genetic counselingS Marlin
Service d ORL Pédiatrique et de Chirurgie Cervicofaciale, Hopital d Enfants Armand Trousseau, and Université Paris VI, Paris Cedex 05, France
Arch Otolaryngol Head Neck Surg 127:927-33. 2001To evaluate difficulties encountered in genetic counseling in deaf children carrying connexin 26 gene (CX26 or GJB2) mutations.
- Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafnessDwan A Gerido
Dept of Physiology and Biophysics, State University of New York, T5 147, Basic Science Tower, Stony Brook, NY 11794 8661, USA
Am J Physiol Cell Physiol 293:C337-45. 2007Mutations in the human GJB2 gene, which encodes connexin26 (Cx26), underlie various forms of hereditary deafness and skin disease...
- Prevalent connexin 26 gene (GJB2) mutations in JapaneseS Abe
Department of Otorhinolaryngology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
J Med Genet 37:41-3. 2000The gene responsible for DNFB1 and DFNA3, connexin 26 (GJB2), was recently identified and more than 20 disease causing mutations have been reported so far...
- M34T and V37I mutations in GJB2 associated hearing impairment: evidence for pathogenicity and reduced penetranceAgnieszka Pollak
Institute of Physiology and Pathology of Hearing, Warsaw, Poland
Am J Med Genet A 143:2534-43. 2007Despite research the role of the M34T and V37I variants of GJB2 in causing hearing impairment (HI) remains controversial...
- Connexin-26 mutations in sporadic and inherited sensorineural deafnessX Estivill
Department de Genetica, Centre de Genètica Mèdica i Molecular, Hospital Duran i Reynals, L Hospitalet, Barcelona, Catalonia, Spain
Lancet 351:394-8. 1998..Congenital deafness is inherited or apparently sporadic. We have shown previously that DFNB1 on chromosome 13 is a major locus for recessive deafness in about 80% of Mediterranean families and that the ..
- A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohortGirish V Putcha
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Genet Med 9:413-26. 2007The aim of the study was to determine the actual GJB2 and GJB6 mutation frequencies in North America after several years of generalized testing for autosomal recessive nonsyndromic sensorineural hearing loss to help guide diagnostic ..
- The prevalence of connexin 26 ( GJB2) mutations in the Chinese populationXue Zhong Liu
Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, Florida 33136, USA
Hum Genet 111:394-7. 2002Mutations in GJB2, encoding gap junction beta 2 protein (connexin 26), are responsible for the commonest form of non-syndromic recessive deafness in many populations...
- Carrier frequency of GJB2 gene mutations c.35delG, c.235delC and c.167delT among the populations of EurasiaLilya U Dzhemileva
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russian Federation
J Hum Genet 55:749-54. 2010..b>GJB2 gene mutations make the largest contribution to hereditary hearing impairment...
- A new large deletion in the DFNB1 locus causes nonsyndromic hearing lossDelphine Feldmann
Laboratoire de Biochimie, INSERM, U587, Centre de Référence des Surdités Génétiques, AP HP, Hopital Armand Trousseau, 26 avenue du Docteur Arnold Netter, 75012 Paris, France
Eur J Med Genet 52:195-200. 2009Mutations in the GJB2 gene encoding the gap junction protein connexin 26 are responsible for up to 30% of all cases of autosomal recessive nonsyndromic hearing impairment (HI) with prelingual onset in most populations...
- GJB2 and GJB6 gene mutations found in Indian probands with congenital hearing impairmentG Padma
Department of Genetics, Osmania University, Tarnaka, Hyderabad 500 007, India
J Genet 88:267-72. 2009..Several mutations in the GJB2 gene and a deletion of 342 kb in GJB6 gene (delGJB6-D13S1830) have been identified worldwide in patients with ..
- A novel missense mutation in GJB2 disturbs gap junction protein transport and causes focal palmoplantar keratoderma with deafnessE A de Zwart-Storm
J Med Genet 45:161-6. 2008..One of the skin expressed gap junction genes is GJB2, which codes for connexin 26 and is associated with a wide variety of keratinisation disorders...
- GJB2 mutations: passage through IranHossein Najmabadi
Genetics Research Center, The Social Welfare and Rehabilitation Sciences University, Koodakyar Street, Daneshjoo Boulevard, Evin, Tehran, Iran
Am J Med Genet A 133:132-7. 2005..Interestingly and unexpectedly, in spite of extreme heterogeneity, mutations in one gene, GJB2, are the most common cause of congenital severe-to-profound deafness in many different populations...
- High frequency hearing loss correlated with mutations in the GJB2 geneS A Wilcox
The Murdoch Institute, Royal Children s Hospital, Melbourne, Australia
Hum Genet 106:399-405. 2000Genetic hearing impairment affects approximately 1/2000 live births. Mutations in one gene, GJB2, coding for connexin 26 cause 10%-20% of all genetic sensorineural hearing loss...
- Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) geneR Rabionet
Deafness Research Group, Medical and Molecular Genetics Center, CGMM IRO, Barcelona, Spain
Hum Genet 106:40-4. 2000Mutations in the GJB2 gene have been identified in many patients with childhood deafness, 35delG being the most common mutation in Caucasoid populations...
- Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancerLuiza Kanczuga-Koda
Department of Pathology, Medical University of Bialystok, Waszyngtona 13, 15 269 Bialystok, Poland
World J Gastroenterol 11:1544-8. 2005To evaluate of Cx26 in correlation with Bcl-xL and Bax proteins in colorectal cancer.
- GJB2 and hearing impairment: promoter defects do not explain the excess of monoallelic mutationsA Pollak
J Med Genet 45:607-8. 2008
- The effects of a connexin 26 mutation--35delG--on oto-acoustic emissions and brainstem evoked potentials: homozygotes and carriersB Engel-Yeger
Evoked Potential Laboratory, Technion, Haifa, Israel
Hear Res 163:93-100. 2002..inner hair cells and the brainstem auditory pathway are impaired due to a mutation in a gap junction protein, connexin 26 (Cx26), 35delG...
- Hearing impairment in Dutch patients with connexin 26 (GJB2) and connexin 30 (GJB6) mutationsRegie Lyn P Santos
Department of Epidemiology and Biostatistics, Genetic Epidemiology Unit, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Int J Pediatr Otorhinolaryngol 69:165-74. 2005Despite the identification of mutations in the connexin 26 (GJB2) gene as the most common cause of recessive nonsyndromic hearing loss, the pattern of hearing impairment with these mutations remains inconsistent...
- Double heterozygosity with mutations involving both the GJB2 and GJB6 genes is a possible, but very rare, cause of congenital deafness in the Czech populationP Seeman
Department of Child Neurology DNA laboratory, Charles University Prague, 2nd School of Medicine, V Uvalu 84, 150 06 Praha 5, Czech
Ann Hum Genet 69:9-14. 2005Mutations in the GJB2 gene are the most common cause of prelingual, autosomal recessive, sensorineural hearing loss worldwide...
- GJB2 mutations in keratitis-ichthyosis-deafness syndrome including its fatal formAndreas R Janecke
Department of Medical Biology and Human Genetics, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
Am J Med Genet A 133:128-31. 2005..Germline missense mutations in GJB2, encoding connexin-26, were recently found to cause KID in 14 unrelated juvenile and adult patients...
- Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafnessMartina Beltramello
Venetian Institute of Molecular Medicine, via G Orus 2, 35129 Padua, Italy
Nat Cell Biol 7:63-9. 2005..Here we describe an investigation of the properties of a recombinantly expressed recessive mutant of connexin 26 (Cx26), the V84L mutant, associated with deafness...
- GJB2 gene mutations in newborns with non-syndromic hearing impairment in Northern ChinaGui Zhi Shi
Department of Forensic Medicine, Medical College of Shantou University, 22 Xinling Road, Shantou 515031, Guangdong, People s Republic of China
Hear Res 197:19-23. 2004Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss...
- The c.IVS1+1G>A mutation in the GJB2 gene is prevalent and large deletions involving the GJB6 gene are not present in the Turkish populationAsli Sirmaci
Division of Pediatric Molecular Genetics, Ankara University School of Medicine, Ankara 06100, Turkey
J Genet 85:213-6. 2006
- Genetic analysis of the connexin-26 M34T variant: identification of genotype M34T/M34T segregating with mild-moderate non-syndromic sensorineural hearing lossM J Houseman
Molecular Medicine Unit, St James s University Hospital, Leeds LS9 7TF, UK
J Med Genet 38:20-5. 2001..GJB2) that encodes connexin-26 have been shown to cause non-syndromic sensorineural hearing loss (NSSNHL) at the DFNB1 locus on 13q11...
- Identification of mutations in the connexin 26 gene that cause autosomal recessive nonsyndromic hearing lossD A Scott
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Hum Mutat 11:387-94. 1998Mutations in the Cx26 gene have been shown to cause autosomal recessive nonsyndromic hearing loss (ARNSHL) at the DFNB1 locus on chromosome 13q12...
- The prevalence of the 235delC GJB2 mutation in a Chinese deaf populationPu Dai
Department of Otorhinolaryngology Head, PLA General Hospital, Beijing, People s Republic of China
Genet Med 9:283-9. 2007Mutations in the GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment in populations studied to date. However, the prevalence of mutations varies among different ethnic groups...
- Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancerYasuto Naoi
Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka, 565 0871, Japan
Breast Cancer Res Treat 106:11-7. 2007b>Cx26, which is a constituent of the connexin family, has recently been shown to promote metastasis through enhancing the vascular invasion in mouse melanoma cells...
- DNA sequence analysis of GJB2, encoding connexin 26: observations from a population of hearing impaired cases and variable carrier rates, complex genotypes, and ethnic stratification of alleles among controlsHsiao Yuan Tang
Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Med Genet A 140:2401-15. 2006Mutations in GJB2 are associated with hereditary hearing loss. DNA sequencing of GJB2 in a cohort of hearing impaired patients and a multi-ethnic control group is reported...
- Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndromeS Yotsumoto
Department of Dermatology, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Br J Dermatol 148:649-53. 2003Germline missense mutations in the GJB2 gene that encodes connexin-26 (Cx26) have recently been found to be the cause of the keratitis-ichthyosis-deafness (KID) syndrome.
- Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulationAlessandro Terrinoni
Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Biochem Biophys Res Commun 394:909-14. 2010The autosomic dominant KID Syndrome (MIM 148210), due to mutations in GJB2 (connexin 26, Cx26), is an ectodermal dysplasia with erythematous scaly skin lesions, keratitis and severe bilateral sensorineural deafness...
- Pathogenetic role of the deafness-related M34T mutation of Cx26Massimiliano Bicego
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, and Servizio di Genetica Medica, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Hum Mol Genet 15:2569-87. 2006Mutations in the GJB2 gene, which encodes the gap junction protein connexin26 (Cx26), are the major cause of genetic non-syndromic hearing loss. The role of the allelic variant M34T in causing hereditary deafness remains controversial...
- Connexin 26 (GJB2) mutations as a cause of the KID syndrome with hearing lossAlessandro Terrinoni
Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
Biochem Biophys Res Commun 395:25-30. 2010..is inherited as an autosomic dominant disease, due to mutations in the gene encoding gap junction protein GJB2 (connexin 26, Cx26)...
- [Mutation of GJB2 gene in nonsyndromic hearing impairment patients: analysis of 1190 cases]Fei Yu
Department of Otolaryngology, Head and Neck Surgery, Institute of Otorhinolaryngology, Genetic Testing Center for Deafness, People s Liberation Army General Hospital, Beijing 100853, China
Zhonghua Yi Xue Za Zhi 87:2814-9. 2007To analyze the sequence of GJB2 gene in nonsyndromic hearing impairment (NSHI) patients in China.
- Connexin family members target to lipid raft domains and interact with caveolin-1Anne Lane Schubert
Department of Molecular Pharmacology and Albert Einstein Cancer Center and Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Biochemistry 41:5754-64. 2002..We also show that other connexins (Cx32, Cx36, and Cx46) are targeted to lipid rafts, while Cx26 and Cx50 are specifically excluded from these membrane microdomains...
- Screening for the GJB2 c.-3170 G>A (IVS 1+1 G>A) mutation in Brazilian deaf individuals using multiplex ligation-dependent probe amplificationSueli Matilde da Silva-Costa
Laboratorio de Genetica Molecular Humana, Centro de Biologia Molecular e Engenharia Genetica, Universidade Estadual de Campinas, Campinas, Brazil
Genet Test Mol Biomarkers 13:701-4. 2009Mutations in GJB2 gene are the most common cause of nonsyndromic sensorineural recessive hearing loss. One specific mutation, c...
- Assessment of the genetic causes of recessive childhood non-syndromic deafness in the UK - implications for genetic testingT Hutchin
Molecular Medicine Unit, St James s University Hospital, University of Leeds, UK
Clin Genet 68:506-12. 2005..Previous studies have shown that one of these genes, connexin 26 (GJB2), accounts for 30-60% of such deafness, but the relative contribution of the many other genes is not ..
- Screening for monogenetic del(GJB6-D13S1830) and digenic del(GJB6-D13S1830)/GJB2 patterns of inheritance in deaf individuals from Eastern AustriaKlemens Frei
Department of Otorhinolaryngology, Medical University of Vienna, AKH 8J, Waehringer Gurtel 18 20, Vienna A 1090, Austria
Hear Res 196:115-8. 2004..Genes such as the gap junction protein beta 2 (GJB2) encoding for Connexin (Cx26) and GJB6 (Cx30) are known to cause sensorineural deafness...
- [The principles of molecular diagnosis of recessive forms of prelingual non-syndromic hearing loss]Joanna Wiszniewska
Zaklad Genetyki Medycznej, Instytut Matki i Dziecka, Kasprzaka 17a, 01 211 Warszawa, Poland
Med Wieku Rozwoj 6:309-18. 2002The GJB2 gene defects are the most frequent cause of autosomal recessive non-syndromic hearing loss (DFNB1). Epidemiological data suggest that 35delG is the most prevalent mutation found in 88% of mutated alleles...
- A genotype-phenotype correlation for GJB2 (connexin 26) deafnessK Cryns
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
J Med Genet 41:147-54. 2004Mutations in GJB2 are the most common cause of non-syndromic autosomal recessive hearing impairment, ranging from mild to profound. Mutation analysis of this gene is widely available as a genetic diagnostic test.
- Clinical features of the prevalent form of childhood deafness, DFNB1, due to a connexin-26 gene defect: implications for genetic counsellingF Denoyelle
Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, Paris, France
Lancet 353:1298-303. 1999b>DFNB1, the locus of an autosomal recessive form of deafness due to mutations in the connexin-26 gene (CX26 or GJB2) is one of the most frequent hereditary defects in human beings...
- Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31Xue Zhong Liu
Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
Hum Genet 125:53-62. 2009Mutations in the genes coding for connexin 26 (Cx26) and connexin 31 (Cx31) cause non-syndromic deafness...
- Mutation spectrum of the connexin 26 (GJB2) gene in Taiwanese patients with prelingual deafnessHsiao Lin Hwa
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
Genet Med 5:161-5. 2003To determine the mutation spectrum of the connexin 26 gene among 324 Taiwanese patients with prelingual deafness and the carrier rate of gene mutation in another 432 unrelated control subjects.
Research Grants12
- Mutant cochlear connexins associated with deafnessGuillermo Altenberg; Fiscal Year: 2006..In most cells of the normal cochlea gap-junctional channels are heteromeric assemblies formed by the connexins Cx26 and Cx30...
- PROPERTIES OF CONNEXIN CHANNELS THAT CAUSE DEAFNESSAndrew Harris; Fiscal Year: 2006DESCRIPTION (provided by applicant): Mutations in the connexin26 (Cx26) gene (GJB2) are the predominant cause of inherited syndromic sensorineural deafness in humans...
- Function and Expression of Connexins in the pre-Botzinger ComplexJONATHAN KELTY; Fiscal Year: 2007..The findings a) that neurons within the rodent PBC express at least some Cx, possibly including Cx26, Cx32, and Cx36, and b) that putative gap junction blockers (uncouplers) affect the generation of bursting by the ..
- Structure/Function Analysis of Low pl Connexin IsoformsELLIOT HERTZBERG; Fiscal Year: 2003..Mutations in Cx26 underlie the most common forms of non-syndromic deafness...
- Connexin Mutations in DeafnessThomas White; Fiscal Year: 2003Mutations in the human connexin 26 gene (Cx26, or GJB2) are the leading cause of nonsyndromic deafness in the United States. Mutations in two additional connexin genes, Cx30 (GJB6) and Cx3l (GJ63), also produce hearing loss in humans...
- CONNEXINS AND CARCINOGENESISHiroshi Yamasaki; Fiscal Year: 1999..data suggest that co-expression of the Cx32 gene in HeLa cells, the tumorigenicity of which had been suppressed by Cx26 transfection, resulted in removal of this suppression...
- ANALYSIS OF CONNEXIN26 IN MOUSE SKIN CARCINOGENESISIrina Budunova; Fiscal Year: 2003..objective of this project is to test this innovative hypothesis using as a model co-expression of incompatible Cx26 (beta2) and Cx43 (alpha1) in keratinocytes...
- New APEX diagnostic for hereditary sensorineural hearing lossPhyllis Gardner; Fiscal Year: 2006..It is an inexpensive microarray, capable of simultaneous evaluation of multiple mutations in 8 genes (GJB2, GJB6, GJB3, GJA1, SCL26A4, SCL26A5 and the mitochondria! genes 12S rRNA and tRNA Ser)...
- Outcomes of Cx26 Testing in Deaf/Hard of Hearing AdultsChristina Palmer; Fiscal Year: 2009DESCRIPTION (provided by applicant): Genetic testing for deafness is now a reality with the identification of Connexin 26 (Cx26, GJB2) as a cause of up to 50% of nonsyndromic sensorineural deafness...
- Effect of co-assembly on the stability of cochlear gap junctionsShoeb Ahmad; Fiscal Year: 2009..Genes coding for Cx26 and Cx30 are the most common cause of hereditary non-syndromic deafness...
- The Human Genome Project and Hearing LossDONNA SORKIN; Fiscal Year: 2001..One speaker, Dr. Heidi Relim of Harvard Medical School, has since authored an article on Connexin 26 testing which will be published in the November/December 2000 issue of Volta Voices, AG Bell's popular magazine...
- GENERATION OF MODELS FOR GENETIC HEARING LOSSDANA ORTEN; Fiscal Year: 2003..Mutations in the gene for connexin 26 (GJB2) are the most common cause of hearing loss (DFNB1) in American and European populations, accounting for ..


text:
Scaling the Excelsior Filming Model
View Single Post
August 23 2013, 11:16 PM
Robert Comsol
Location: USS Berlin
Re: Scaling the Excelsior Filming Model
Praetor wrote:
Do you have a particular vision for how the transwarp drive would be a modular unit? Seems to kind of defy the notion of a warp core as we know it... or even the intermix chamber of TMP.
Damnit, I'm a deck plan designer, not a transwarp engineer!
Might have something to do with tapping into the main navigational deflector or the creation of exotic energy. We'd first have to figure out the defining characteristic of "tranwarp". Can't TNG's "Descent" provide some clues?
Praetor wrote:
In my TM writeup, I sort of concluded that Admiral Morrow had it out a bit for the
(because he was making his legacy in the
) and that Kirk and Styles were rivals from the Academy.
Possible, but Styles was an egotistic prick and everybody would have been his rival
Frankly, I think that guy was a loose cannon, totally unqualified for any high-profile diplomatic mission and Starfleet was in desperate need to give this guy an assignment where he couldn't do harm. Testing the
for performance would qualify as such, IMO.
Praetor wrote:
Odd little tidbit. I shall have to work that into my TM. I trust you won't let me forget it?
Do or do not. Just bear in mind that there is a high probability that German fans like Bernd Schneider, Tobias Richter and others would instinctively notice the absence of the name of the ship's designer "Thorndike".
I do not know from where "
er Synchron Wenzel Lüdecke" got the idea to use this name in the dubbing to identify the Excelsior Class designer. But there is some odd coincidence that we do have an Excelsior Class
(NCC-14232). In a manner of speaking there is a connection Thorndike-Berlin-Excelsior Class.
Praetor wrote:
I always assumed that took place on Earth.
The movie suggests your assumption is right, looks like you missed my comment while writing yours.
The first duty of every Starfleet officer is to the truth"
Jean-Luc Picard
"We can't solve problems by using the same kind of thinking we used when we created them."
Albert Einstein
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Carolyn Thomas, President Carolyn has been a teacher and administrator for 30 years and a student for even longer. She currently teaches in the philosophy department at University of New Mexico. Carolyn has degrees from Duke, Stanford, St. John's College, and University of New Mexico. She loves books, ideas, conversation, and learning. She's also a member of the Studebaker Drivers Club and enjoys tinkering with old cars and trucks.
Bruce Miller, Vice President. Bruce received a B.S. degree in Civil Engineering from Carnegie-Mellon University and an MBA from the University of Chicago. He has worked in the field of corporate finance for over 30 years and currently is working as a finance executive with three technology companies in Santa Fe and also serves on the board of directors of the Santa Fe Business Incubator. Bruce's two daughters are graduates of the Santa Fe Girls' School.
Sheila Jael Vaughn, Vice-President. Sheila is a psychologist who spent 30 years in private practice in southern California, where she specialized in working with adolescents. She was an adjunct professor at the University of California, Irvine, where she taught developmental psychology. Sheila's activities, since her recent move to Santa Fe, include board member at Girls' Inc., developing her consulting business, and hiking with her retriever.
Cindy Onore, Secretary. Cindy is an Emeritus Professor of Education at Montclair State University in New Jersey. She holds a MA in English and a Ph.D in English Education from New York University. Cindy taught junior and senior high school English in Newark, NJ and in New York City before serving as a faculty member in teacher education at several universities in the New York area including the New School University and Columbia University Teachers College. For over 30 years, Cindy's work in teacher preparation and professional development has focused on urban education. She is the author of two books and numerous articles and, although retired, she continues to write and publish scholarly work. Cindy moved to Santa Fe in 2012. She loves to dance, hike, and run.
Melissa Benedict, Treasurer. Melissa is a graduate of St. John's College in Santa Fe, earned a masters degree in psychology from the Goddard Graduate Program and studied accounting at the Anderson School at UNM. She has many years of experience in accounting and management for not for profit organizations, including seven years as finance director for a private school. She has volunteered for political action groups, music organizations and several Santa Fe schools.
Lee Lewin is a co-founder of the Santa Fe Girls' School and a professional educator. She serves as the educational director for the School. She is licensed by the state of New Mexico to teach grades K through 8 and has earned the state's bilingual education endorsement. She holds two undergraduate degrees, one in Russian language and literature and the other in education. Lee devotes volunteer time to the community in the area of civic affairs.
Janet Graham is the school's administrative director. She has over 30 years of teaching and administrative experience. She earned her undergraduate degree in education from Colorado State University and holds a graduate degree from St. John's College.
Joan Brooks Baker is a photographer, and a native New Yorker, who has lived in Santa Fe for almost 30 year. She is a devoted member of the community of Santa Fe, not only for its beauty and energy, but for its enthusiastic blend of three cultures and a unique appreciation of its core place in the creative world. Joan's fascination for the past several years with the history and presence of the Black Madonna has resulted in a current slide presentation of Black Madonnas and her portraits of women.
Elaine Sullivan received her master's degree in Education at Xavier University, Cincinnati, Ohio, and her master's degree in Applied Behavioral Science at the Leadership Institute of Seattle. She has retired from 25 years in corporate consulting and training and now does part-time marketing and human resources work in a local medical acupuncture practice. She was a co-founder of the Santa Fe Chapter of PFLAG (Parents, Families and Friends of Lesbians and Gays) and of the Santa Fe Alliance, which works to support locally-owned businesses and to educate Santa Feans about the value of keeping our dollars circulating in our own community.
Bettina Lancaster attended an all-girls school for all of her grade school years in New York City, at the Spence School. She raised two children, while pursuing a BFA in painting at the College of Santa Fe. After her eldest child went to college, Betting opened a studio/gallery on Canyon Road, called the Flying Fish Gallery, where she hosts many types of creative events and workshops. She recently completed yoga teacher training, and is working on a book about creativity.
This School does an amazing job. I have been teaching there 15 years and seen class after class of girls change into their own womanhood and power. It is the most thoughtful staff and curriculum I have ever encountered.Joan Logghe, Poet-in-Residence/ President, NM Literary Arts
The school's standard for excellence is what prepared me most for high school. The most important thing the staff does is teach their students a work ethic. Among other things, they stress that the only one who can learn for you is you. Your teachers respect and help you and expect you to behave respectfully and help keep the classroom a place to learn.Alexandra Gentsh, Graduate, student at St. John's College
Santa Fe Girls' School over-prepared me for any school, if there is such a thing. Even more important, they gave me the confidence to excel!Moriah Major, Graduate, student at University of San Francisco
It is a girl-only school for 6, 7 and 8 graders that focuses on rigorous learning and as importantly, self-esteem and giving girls the inner tools they need to negotiate life without sacrificing who they are. I was so inspired by the dedication and focus of the teachers, but more importantly, the passion and expression of the girls left me awestruck. We need more strong women in our world!Katrina Godshalk, Community Member
At the Santa Fe Girls' School I began to discover my passion and gain the tools I needed to be successful. My experience with the unique, hands-on environmental program inspired me to pursue a degree in Watershed Science. The school provided an incredible base for developing my confidence both inside and out of the academic world.Melissa Miller, student at Colorado State University, Watershed Science with a minor in Spacial Information Management


text:
We would like to make Apple Mac OS X a first class platform for astronomy and astrophotography. With everything you may need and what is available on another operating systems.
We have started with porting INDI framework and INDI drivers to Homebrew package manager, continued with INDI server GUI, control panel and FITS format viewer and finally now we are working on the most important pieces, the family of tools for astro-photographers. The first two of them, AstroImager and AstroTelescope, are already available for download. Read more »
INDI platform with its network transparency is very well suited for remote control. Why not to check the status of your observatory or the progress of the imaging session with your iPhone or other iOS device? Read more »
Astronomy is our main focus, but we have also something completely different. Karel the Robot, visual environment for programming language for kids for your iPad. Read more »
Even if we are developing for OS X and on OS X a lot of code can be used on any other unix operating systems as well. We are offering INDI drivers for Linux for many devices not available from the standard INDI distribution for free.
However, if some driver is still missing and is available for ASCOM, you can use our .Net ASCOM-to-INDI bridge running on Microsoft Windows to complete your puzzle. View details »


text:
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I have been a patient of Dr. Newman for over 25 years. I cannot remember dealing with a doctor who is more passionate about his work and is so up to date about everything in his field. My entire family are patients. I have recommended many people I know all with thanks for sending them to Dr. Newman. He was instrumental in my oldest son becoming an ophthalmologist.
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Dr Newman is amazing. Such a wonderful office. Highly recommended
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I've read articles about people who enjoy their jobs and can't wait to go to work, but I have never actually met one of them. That is, until I had an appointment with Dr. Michael A. Newman in Ewing, NJ. I've worn contact lenses for years which worked for day vision, but my night vision was very poor. It finally got to the point of me switching to glasses for night driving with the hopes that the Crizal coating would help with the glare. It did slightly. I met someone who recommended Dr. Newman and despite the fact I live in Toms River, he is well worth the drive to Ewing. He recommended a couple of different things and the final result…SynergEyes Duette HD lenses did the trick! He is very passionate about his work, very innovative and very knowledgeable. I would recommend him to anyone in a heartbeat. He also has a great office staff working with him.
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I have been a patient of Dr. Newman for more than 25 years and appreciate the care and passion he has for me as a patient. He takes his time and explains things clearly in layman's terms and works hard to keep my vision 20/20.
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Have been a patient for over 20 years---office staff is always courteous and prompt--dr newman is precise, professional, runs on time, and is the best lens fitter in the area!!
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I have been a patient of Dr. Newman's for more than 30 years. Dr. Newman still affords me the same dedication and concern for my vision issues as he did the first time we met. He is always striving to give me the best of what is available for my low vision condition. A more dedicated doctor would be hard to come by. I so appreciate the time and effort that has been put into my eye care. Lynn D'Ambrose
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Price included one year supply of disposable contacts. I have been a patient of Dr. Newman's for 33 years. He is the best eye doctor ever. He is passionate about his profession and it shows in the care he provides to his patients. He does everything he can to meet your needs, and like many other reviewers, I too have a difficult perscription. I have recommended him to dozens of friends and will continue to do so.
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For contact lenses - this is the place to go. Tried so many others who said I couldn't wear lenses. Well, Dr. Newman took the time to set me up with what I needed and I've been wearing lenses for years now. Wouldn't go to anyone else!
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Dr. Newman came highly recommended several years ago and he has not disappointed. I very much appreciate his thorough exams. He will make sure you are comfortable in the contacts you wear everyday. Every time I hear someone say they need to see an eye Dr, I recommend Dr. Newman. I will be his patient until he decides to retire.
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By Owen West
Free Press, $26, 352 pages
When the United States invaded Iraq and toppled its government, it also made the tragic mistake of disbanding Iraq'sarmy. The Iraqi army was a corrupt and largely ineffective force, but an army nonetheless. This meant that we had to rebuild the Iraqi armed forces from scratch. In the heady days following the fall of Saddam Hussein, the plan to build this new Iraqi army envisioned the use of retired drill instructors as contract trainers. Initially, the new army of Iraq was forbidden to have a domestic role and was to be used for defense against external invasion only. That plan was quickly torn to shreds by the rise of an unexpected insurgency.
By early 2004, it had become obvious that counterinsurgency advisers were needed, and the Defense Department ordered the U.S. Army and the Marine Corps to provide them. But where would they come from? The special forces were far too small to build an entire army. Both services turned to improvisation, and that meant dragging officers and enlisted men out of the reserves, the supporting establishment and the service school houses. The author's father, Bing West, and I were asked to be part of a group tasked to help the Marine Corpsdraft an advisory school curriculum. We had to go to the Marine Corps historical branch to find Vietnam-era instructional materials to use as a guide.
Owen West's "The Snake Eaters" is the account of one team of advisers in Iraq, but the author skillfully uses it to tell the story of the entire advisory effort. Team Outcast was a group of advisers with the 3/3-1 Iraqi Battalion, the Snake Eaters of the title. The advisory team was made up of reservists, whose civilian occupations ranged from Drug Enforcement Administration agent to flooring manager.
The author joined the group rather late. His day job is as a Wall Street trader. The group received totally inadequate training to prepare them for the delicate job of advising host nation troops. There was a presumption among those who trained Team Outlaw that the team would live on a large, fixed base and simply hold classes for their Iraqi students. Instead, they ended up living and fighting with those Iraqis they were assigned to mentor.
To make matters worse, the National Guard unit designated to support Team Outlaw failed to do its job and treated the members as true outcasts. But like so many similar advisory units, Team Outcast succeeded in spite of the enormous challenges it faced. The team operated in one of the most hostile cities in the most dangerous province in Iraq in those days. It was fortunate in being partnered with Maj. Mohammed, an Iraqi officer who may not have liked Americans but knew that he had to work with them. Mohammed made up for much of the cultural training that Team Outlaw should have had but did not. With the team's help, the Snake Eater battalion eventually earned the respect, if not the love, of the city's population. It also became the first Iraqi battalion to take control of its own battle space.
Owen West is a Marine Corps reservist who has written some fine fiction. The book reads like a novel and points out some lessons that should be learned in preparation for future conflicts but probably won't be. When the Vietnam War ended, there was a virtual stampede to forget its lessons, and in Iraq and Afghanistan, we paid in blood and treasure for that shortsightedness. History may repeat itself.
As the author points out, some of the skills needed in a good adviser are often the opposite of those treasured by the regular army establishment. Original thinking and informal small group dynamics are important in the adviser's world but are not at all prized in the regular combat brigades that made up most of the combat strength in Iraq and Afghanistan.
Although the homegrown Sunni insurgents and the foreign jihadists of al Qaeda were dangerous, the real enemy that Team Outcast faced was careerism. Although the advisers were the real ticket home for the Americans in Iraq, as they are in Afghanistan, regular military establishment doesn't often look at advising as a career-enhancing posting. Fortunately for the United States, there was a wide pool of reservists and active duty soldiers who would rather be in the real war than sit behind the wire at a forward operating base getting fat at Burger King. Owen West has done a superb job of telling their story.
Gary Anderson is a retired Marine Corps officer. He has served as a counterinsurgency and governance adviser in Iraq and Afghanistan for the Defense and State departments.


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Great Uptown Location 1 block off Hennepin and and Franklin Ave...popular Wedge location in Uptown!
Our Uptown apartments feature classic buildings, outstanding management and locations that are second to none. Right out your door you'll find everything to make life fun and easy - from fabulous restaurants to trendy shopping to neighborhood coffee shops. Join one of Steven Scott's Uptown communities. You'll be glad you did!
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33 units
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