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El Cajon The San Diego Humane Society and SPCA are opening a new adoption center to make it more convenient for East County residents to find the perfect shelter pet.
The Petco store at 540 N. Second St. in El Cajon will have a grand opening event to mark the occasion from 4 to 7 p.m. Wednesday, with festivities continuing through the weekend.
The city also has its own shelter with adoptable pets at 1275 N. Marshall Ave. The El Cajon Animal Shelter is open 10 a.m. to 5:30 p.m. Tuesday through Saturday.
Petco and the Humane Society have set a goal to find homes for 50 animals throughout the grand opening weekend.
The adoption center will be a permanent fixture at the store.
It is the first time the Humane Society has partnered with a pet store for adoptions, and its first official foray into the East County. The group has long had a presence on Gaines Street in central San Diego; its North County campus opened in Oceanside in June 2011.
In conjunction with East County Animal Rescue, there will be puppies, dogs, kittens, cats and rabbits available at the new adoption center.
"We're proud to partner with Petco to open our newest adoption center, which will be more accessible to adopters in the East County area," said Dr. Gary Weitzman, president of the San Diego Humane Society and SPCA in a news release. "We've greatly increased our adoption goals this fiscal year, and this adoption center is an additional step toward achieving that goal. It will help us reach more adopters to find homes for even more animals in our care."
On Wednesday and throughout the weekend, there will be raffle prizes, giveaways, photographs with Santa, a live in-store radio broadcast from The Walrus 105.7 FM, along with pet adoptions.
Karen Pearlman • U-T


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Designer and Project Runway judge Michael Kors pledged on Monday to give $1 million to help with Hurricane Sandy relief, joining many other celebrities in relief effort.
Kors is donating the money to the American Red Cross Disaster Relief Fund, according to Women's Wear Daily.
"As a New York-based company, to see so many of our employees, customers and neighbors so greatly affected by Hurricane Sandy is unfathomable," Kors stated. "Being a lifelong New Yorker myself, born and bred on the beaches of Long Island, to see this devastation and loss is heartbreaking. We are making this donation in hopes that we can help all those whose lives have been irrevocably altered by Hurricane Sandy."
The Council of Fashion Designers of America and Vogue also promised to help with the relief effort with a fund-raiser called Fashion for Sandy Relief.
Michael Kors is one of the latest celebrities to donate money for the relief effort.
USA Today reports the Dave Matthews Band promised to give $1 million to the Bama Works Sandy Relief Fund. The money from their November 30 show in East Rutherford, N.J. will be donated, along with the merchandise sales.
MTV aired a special, Restore the Shore, on Thursday night to raise money. Many MTV actors showed their support and took calls, including cast members from Teen Wolf, Jersey Shore and Awkward. All of the donations will go to Architecture for Humanity.
Photo Courtesy of Image.net

subset: commoncrawl


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The Twilight Saga: Breaking Dawn – Part 2 (commonly referred to as Breaking Dawn – Part 2) is a 2012 American romantic fantasy film directed by Bill Condon and based on the novel Breaking Dawn by Stephenie Meyer. The second part of a two-part film forms the fifth and final installment in The Twilight Saga film series, and is the conclusion of the 2011 film Breaking Dawn — Part 1. All three main cast members, Kristen Stewart, Robert Pattinson, and Taylor Lautner, reprise their roles, with Mackenzie Foy portraying Renesmee Cullen.
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Review: GarageBand 2 Hits the Note
Almost perfect, GB 2 is on key (April 5th, 2005)
MacNN Rating:
Product Manufacturer: Apple Computer, Inc.
Price: MSRP: iLife $79 (or included with new Macs)
The Good
- Best entry level audio recording application around, low cost, nice set of features and range of built-in sounds
The Bad
- No MIDI out, no music printing.
When GarageBand first hit the streets, it was a bold move to give the average Mac user the ability to easily and inexpensively record and sequence music, and see what happens. This musical version of iMovie drew quite a few musicians to the Mac, and it was close to being the most effective entry level music production tool possible. At version One all it needed to be the best starter on any platform was three things: notation (allowing it to be used in music theory classes), MIDI output (to allow controlling external devices), and multitrack recording. Those three missing features made choosing Logic (or elsewhere) an easy decision. When GarageBand 2 (GB2) came out it, with the release of iLife '05 Apple included a couple of major features, multi-tracking and traditional notation. These new features bring it closer to the perfect every-man's music studio, but there are issues that still need to be addressed. GB2 now supports up to 255 tracks of audio. Anybody out there need more? Didn't think so. Now you can record eight tracks at once, which is the magic number to record a small rock ensemble live (i.e., all at once) plus giving the drummer those four mikes that he insists on using. There is still no official way to send MIDI out of the application to run external sound modules. Two out of three isn't bad and GB2 is a major upgrade that deserves all the kudos you can throw its way.
NotationMusical notation of MIDI events is truly welcome and Apple made it easy to access and use. Many people don't need it, but this allows score based entry of music that fills out a professional level need. The designers have done one of the coolest jobs of note editing ever seen. When you select a note for changes, the matrix view (MIDI piano roll) appears behind it so that you can change the duration of a note or group just by dragging the on the length bar. Changing staff position and pitch is by selection and dragging or select and cursor keys - very easy and intuitive.
This new approach is a great way to teach players to transition from one form to another. Very nice and it would be perfect if it worked correctly on chords, but it cannot display in notation view a change made to a single member of that chord. The sound is correct but the notation is wrong. Tragically speaking, Logic is guilty of much the same approach, unless one delves into more complex note entry methods. This is something that needs more work.
LimitationsAnother inadequacy is that you cannot insert key signature changes, so notation entry could get messy if the tune modulates. This limitation makes transcribing a song like "Body and Soul" a chore. The same limitation goes for time signatures. While some think that those changes are obscure, all you need to do point to the Fab Four's "Good Day Sunshine" and realize that a few classic rock songs would pose a problem for GB2 notation. Other than screen shots, GB2 does not allow printing of scores so there's no way to create a part for other players in this application. This clearly is an area where some version of Logic is the solution. Perhaps that is Apple's intention.
New PluginsApple added three very useful plugins to GB2 that brings in some of the power of Logic 7. First, there's the pitch correction that allows you to perform the wondrous feat of applying good intonation to a bad vocalist. Second, a beat correction tool works against recorded audio tracks, locking sloppy events into the song's tempo. Third, Vocal Transformer allows the switching of gender characteristics on vocal tracks. These tools are easy to use and work realistically if used sparingly. They can also be used (actually abused) to mangle tracks creatively when applied without restraint. One of GB2's other limitations, following key and time signatures, is that effects must remain constant for the entire track. Only volume and pan can change.
GarageBand and the Logic products use CoreAudio/MIDI which means, in the simplest terms, that they all share basic functions like sound recording, MIDI, and the ability to support Audio Units (AU's). All those AU's work the same way in all three products. Like its Logic cousins, GB2 supports ReWire. All three products share a common engine and this shows in looks as well as capabilities and the fact that they can use identical recording hardware running through identical CoreMIDI and CoreAudio. In a different direction, AppleLoops was added to both Logic products so GB2 just became the perfect scratchpad for Logic.
What GB2 has going for it is an incredible feature set for what is essentially a freeb package. It uses common technology, so it is the perfect appetizer application for audio recording. It is well designed and is intuitive, useful and stable. Even an experienced Logic user may turn to it when inspiration strikes and can later bring the results into Logic for refinement or expansion without losing original content or quality.


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I hope that the State Farm Neighborhood Sessions in Bronx, whatever the fuck THAT is, truly appreciated this top quality pop diva performance.
Jennifer's best effort at a "Taint Jutsu" still didn't get her through the chunin exam.
I appreciate the depth she gets doing squats.
I must admit the view is great.


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Apartment with pool
from £30 /night help Price for guests, Nights
from £30 /night help Price for guests, Nights
Estimated nightly price based on a weekly stay. Excludes fees (if applicable). Enter your dates to see the total cost.
Apartment / 2 bedrooms / sleeps 4 Home 131746
Availability Your dates are available
Apartment / 2 bedrooms / sleeps 4
|Key Info
Spacious 2 bedroom apartment sleeps 4 comfortably, one double and one a twin. A middle floor apartment (some steps) in a gated community. Cable TV, balcony and communal pool.
The large kitchen area is very well equipped and is provided with every thing you will need to enjoy your holiday. Each light is fitted with a fan to make your stay more comfortable in the hot summer months.
The lovely clean community pool is located alongside the block and access is restricted via security key, to occupants of the apartments on the development only.
Near to the famous Plaza with all the restaurants and shops but without the noise! The apartment is centrally located in a safe and secure gated community for your peace of mind when you are on holiday. There is a lovely balcony area with table and chairs for you to relax in the evening or to enjoy breakfast outside!
As well as it being a 'golfers paradise', there are good safe blue flag beaches just a short drive away, these ranging from isolated coves for secluded bathing, to lively beaches with plentiful bars and restaurants. Ideal location for visiting Alicante to Cartagena with Benidorm being only an hour and a half away!
In the summer months there is evening entertainment for children, with the atmostphere also being perfect for couples, families and golfers. The lovely La Zenia beach is only a 10 min drive away, with a number of other lovely beaches nearby along the same coastline. The nearby market in San Miguel is excellent for bargain hunting!
|Sleeps up to 4, 2 bedrooms
|Nearest beach
|La Zenia 5 km
|Will consider
|Long term lets (over 1 month)
|Car not necessary
|Nearest travel links
|Nearest airport: Murcia (San Javier) 20 km
|Family friendly
|Great for children of all ages
|No pets allowed, No smoking at this property
Features and Facilities
|DVD player
|Shared outdoor pool (unheated)
|TV, Satellite TV
|Kettle, Toaster, Iron, Hair dryer
|Clothes dryer, Cooker, Microwave, Fridge, Freezer, Washing machine
|2 bedrooms, 1 bathrooms of which 1 Family bathrooms
|Double beds (1), Single beds (2), Dining seats for 4, Lounge seats for 4
|Linen provided, Towels provided
|Shared outdoor pool (unheated), Balcony or terrace
|Parking, Not suitable for wheelchair users
|Further details indoors
The property is managed and cleaned thoroughly after each guest.
Clean linen and towels are provided. A phone number of a local English resident is supplied should any problems arise.
|Further details outdoors
Just outside the gated complex there are a number of parking spaces available if you are to arrange car hire.
A lovely grassed area surrounds the well maintained outside pool.
The apartment has a nice balcony area furnished with patio furniture.
The Canary Islands region
Torrevieja is the nearest major town which is only 15 min drive away. It is surrounded by salt lakes and as a resort the climate is meant to be very healthy especially for people with arthritis.
Go Karting is just 10 mins drive on the N332. A fantastic race with cafe bar, viewing gallery and funfair for little ones! The Go Karts cater for ages from 3 years old plus.
The local water park is situated in Torrevieja and a must for families.There is also the convenient location of the motorway (1k away – far enough to not be heard or seen but convenient enough for those get away days). A must day out & within 1 hour is the famous Terra Mitica theme park (Disney style but without the dwarfs or Mickey!).
Las Filipinas
There are a number of restaurants, bars and shops within walking distance of the apartment. Villamartin Plaza is only a short drive or 20 minute walk where you will find a choice of lovely restaurants and bars as well as children activities in the summer months.
This area is a golfers delight as there are 3 beautiful championship courses of international prestige (Villamartin, Campoamor and Las Ramblas within a 5 minute drive of the apartment). Within a 30 minute drive you can choose from another 8 courses including the world famous La Manga and La Finca courses.
To enjoy the location and surrounding areas we would recommend renting a car although in the summer months there is a local bus service which is very reasonable in price.
We can also put you in touch with a local English driver who would be able to drive you around, again for very a very reasonable cost. If you do hire a car there are plenty of parking spaces available very close by.
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- 3 Years listed
40% Response rate
Calendar last updated:08 Jan 2015
Based in United Kingdom
- English


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Munich, Germany August 27 2012: Renal denervation leads to better outcomes than standard drug treatment in patients with advanced heart failure, according to research presented at ESC Congress 2012. The results of the Olomouc I pilot study were presented by Dr Milo Tborsk from the University Hospital Olomouc.
Renal denervation does not involve any pharmacological treatment. It is a multiple application of radiofrequency energy using a thin catheter via the femoral artery and a long-term "denervation" of the sympathetic nerves around the renal arteries. "This is done to prevent an increased excretion of the substances leading to heart failure," said Dr Tborsk.
The aim of this pilot study was to compare the outcomes of patients with advanced heart failure receiving standard pharmacological treatment or renal denervation. Over the period of one year, 26 patients were treated with renal denervation and standard pharmacotherapy and 25 patients received standard drug treatment with beta-blockers, ACE inhibitors or ARBs and diuretics.
After one year contractile function of the left side of the heart improved in patients treated with renal denervation from 2512% to 3114% (p<0.01).
There was no change in contractile function of the left side of the heart in patients who received standard drug treatment. "The improvement of the contractile function of the left side of the heart by more than 10% in patients after renal denervation was a surprise," said Dr Tborsk. "This parameter has practically not changed in patients treated by the classic drugs. The difference in response might be explained by a continuous decrease of the renal sympathetic activity in the complex pathophysiology of heart failure."
During the one year follow-up, 8 patients treated with renal denervation were hospitalized due to heart failure compared to 18 patients treated with standard drug therapy. Dr Tborsk said: "Twice the number of patients treated by
|Contact: ESC Press Office
European Society of Cardiology


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Provide a sturdy and stylish platform for your television with the Southpark TV Stand. This stand can be placed in your bedroom, and gives you a wide variety of options to store all your electronics. Its large top easily accommodates a large LCD TV. This bedroom furniture has two drawers, for concealed storage and an open shelf for your CD or DVD player. The TV stand's contemporary style and dark espresso finish make it an elegant addition to any theme.
Email Sent.


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10 October 2015
SEPANG – Malaysia Airports Holdings Berhad (Malaysia Airports) is proud and honoured to celebrate Hari Sukan Negara, an initiative by the Ministry of Youth and Sports to turn Malaysia into a sporting nation. The ceremony which was held earlier today at its main terminal, KL International Airport (KLIA) seen participation of more than 180 Malaysia Airports employees.
Clad in full sportswear, the management and employees of Malaysia Airports took part in the three-hour event filled with many exciting activities like aerobic sessions, 'AIRmazing Race' around the main terminal building and some other fun indoor games.
In his opening speech, Tuan Hj Zainol Md Isa, the General Manager of Malaysia Airports said, "Such a programme brings more than joy to us. Beyond the obvious health benefits, sports teach us much about life. It teaches us about teamwork, getting along with others, and how to work together to achieve a common goal. On behalf of Malaysia Airports, I congratulate YB Khairy Jamaludin and the Ministry of Youth & Sports for making this a national event."
Malaysia Airports believes in the importance of promoting a healthy lifestyle for employees. As such, the company organises regular sports activities and events, which includes its monthly aerobic sessions for employees and passengers at KLIA and klia2 terminals, inter and intra department football tournaments, and other indoor and outdoor sports activities. These activities not only brings much cheer and enthusiasm, it also promotes healthy competition and strengthen the relationship amongst its employees.


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All Jackets - MensSave on Men's All Jackets at Proboardshop.com! Great selection of street gear at unbelievably low prices. Proboardshop has been selling All Jackets and outdoor gear for over 30 years and we're proud of it.
Please refine here
- Brand: Columbia
- Size: XX-Large
Columbia Ascender II Softshell JacketReg: $115.00 On Sale: $74.95
Size: Medium, X-Large, XX-Large
Columbia Ballistic III FleeceReg: $106.00 On Sale: $63.95
Size: Small, X-Large, XX-Large
Columbia Half Life Reversible II Jacket
Size: Large, X-Large, XX-LargeReg: $150.00 On Sale: $97.95
Columbia Heat 360 II 1/2 Zip Fleece 2014Reg: $90.00 On Sale: $55.95 - $58.95
Size: Small, Medium, X-Large, XX-Large, XXX-Large
Columbia Two Lives Reversible JacketReg: $120.00 On Sale: $71.95
Size: Small, Medium, Large, X-Large, XX-Large


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JORDAN NAILON | Friday marks start of bear season
The long wait is over for hunters itching to get back to the woods, rifle in hand as Friday marks the start of bear hunting season in most areas of Washington, including the Puget Sound.
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The comfort guarantee offers a 30 day refund if not happy. The Mattress Return policy says that mattresses are non refundable if opened. How does this work?
Overstock never disappoints me. Great value for this mattress. My son loves it. Delivery was wonderful!...
- Size: Full
- Set includes: Mattress, foundation
- Construction: Plush
- Support: Firm
- Materials: Pillo-Fill Fiber, FireBlocker Fiber, Visco Memory Foam, SertaFlex Innerspring
- Serta's breathable Pillo-Fillmaterial is designed to enhance both airflow and moisture wicking at the sleep surface. Together, these properties can help promote a cooler and more comfortable sleep
- Serta's Memory Foam gently conforms to your body and contours to your sleeping position for enhanced cushioning and comfort
- Our SertaFlex Innerspring uses an offset coil design to ensure maximum flexibility and responsiveness to the contours of your body while you sleep. Plus, the alternating coil design enhances stability while strengthening the mattresses edges.
- Certifications: This mattress set meets all federally mandated flammability standards with Serta's patented FireBlocker system.
- Mattress set: 20 inches high x 53 inches wide x 74.5 inches long
- Mattress dimensions: 11 inches high x 53 inches wide x 74.5 inches long
- Foundation: 9 inches high or low profile 6 inches high x 53 inches wide x 74.5 inches long
White glove home deliveries require a 4-hour window to complete delivery; this includes delivery of the mattress, set-up in the room of your choice, removal of all packaging and debris and removal of your old mattress upon request.
30-Day Comfort Guarantee - If you are not satisfied with your purchase within 30 days, you may return your order for a refund less a re-stocking fee. After 30 days, the mattress cannot be returned.
|Mattress Type
|Hybrid Innerspring Memory Foam Sets
|11 Inch
|Memory Foam Type
|Foam Memory Foam
|Mattress Top
|Plush Top
|See description
|10 year Limited Manufacturer
|See description
|Model Number
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Customer Reviews
- Disclosures & Guidelines
- Filter By:
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Happy customer
Overstock never disappoints me. Great value for this mattress. My son loves it. Delivery was wonderful!Read More
Very comfortable and I am very pleased with my purchase. Delivery was excellent and on time.Read More
I bought this mattress set for my guest room. My son and daughter in law came to visit for a week. They both loved it. They said it was very comfortable. I slept in that room the other night as I was not feeling well and coughing. I didn't want to keep my husband up all night. I must say it was awesome. I will be getting this mattress for my bedroom. In a bigger size. As I have a queen size in my bed room.Read More
Elizabeth M.
Looking for replacements as the guest bedrooms were long overdue, Bought two said "sets", and would recommend them. I have slept on one and can not tell the difference from my 1400.00 set and this one.Read More
Love it!
Great mattress for the price.Read More
Nice mattress
This is a nice mattress and all three guests who have slept on it expressed the fact that it was very comfortable and they had a solid night's sleep. The only disadvantage is that the edges all the way around the mattress are soft, so if you sit on the edge of the bed, you "sink." This is not true for any other section of the mattress, only the edges. That is the one thing I would change about this product. There should be support throughtout. The product arrived in perfect condition in a very timely manner. All in all, my husband and I are quite pleased with it and it suits our purpose of providing a comfortable night's rest to our many house guests.Read More
i needed to buy this bed sooner!! :D
i've been shopping for a bed for some time now , i needed something firm but still pillow top, it stopped me from getting the revival firm mattress and instead bought this one which has a good pillow top .it is the same one that is on the picture . when i ordered it came quickly actually about in about a week i was surprised on how fast .i slept on it for two night now and it feels amazing . it is not to firm and not to soft really like in the middle. it didnt come in a box but in clear packing as well as the box spring which i didn't mind because it made me see clearly that there was no damage to it.Read More
I was about to pay $800.00 for a full size mattress, at a well known mattress brand name store. I remembered that my sister bought her mattress, on line at Overstock and she loved it. Well, I am so happy I did because the mattress is just perfect. The delivery was also, exceptional. We couldn't be happier. Thank you Overstock on your wonderful prices!Read More
Great Deal
We shopped for a mattress locally and were disappointed by the prices. This mattress was the same one we had seen in our local store but the price difference was almost $$$. It's a nice mattress, very comfortable, and the delivery service was excellent.Read More
Delivery was prompt and polite. This mattress and boxspring is fine, but it is a little too bouncy. I have one family member that loves it and one that despises it, so it is all personal taste. It is better for a lighter weight person without back problems.Read More
Questions & Answers
Hello DeanR, Serta does have a 30 day money back guarantee if you are not satisfied, minus a restocking fee. All of our other mattresses are non returnable once opened. Thanks for shopping with us!
Why did you choose this product?
size and material
I like Serta Mattress
I didn't want a foam top and this mattress/foundation set seems to be well-priced and attractive.
I trust the name and it was a really great price.
Price, Delivery, Reviews.
i have an old frame
Do you do lay always?
Hello OstkUser19401, no, we do not have a layaway option. I hope this helps. Please let us know if you have any additional questions. Thank you for shopping with us!
Will this foundation fit a platform bed. When I moved they pulled the wood slots out and now they are bent. It is a full size frame
Hello rncindy, this item may be too large for a full size frame. It can work with most platform frames. Thank you for shopping with us.
what does the foundation consist of?also which are the similar ones that have frames?
Hello okinakneeo17, this foundation uses an offset coil design to ensure maximum flexibility and responsiveness to the contours of your body while you sleep. Plus, the alternating coil design enhances stability while strengthening the mattresses edges. Thank you for shopping with us!
Does the foundation come in one piece, or does it have to be assembled?
Hello dd525, This arrives in one piece. Thanks for shopping with us!
The foundation is a one piece item for this size bed. If it were a KING, it might come in two pieces.
Is this mattress a no-flip mattress?
We are still researching this and should have the answer shortly.
Thank you for shopping with us tidycat443. This is a non-flip mattress. Have a great day.
I was surprised to find out it was a one-sided mattress when it arrived. You can spin it but not flip it.
how many coil springs are there in the full size
Hi storma, we were able to verify this information with our support team. This item has 312 coils in full size. Thanks for shopping with us.
Hi there. Does this mattress set include a frame to set it up?
Hello katelmadden! This set has received excellent reviews! This set includes the mattress and foundation; unfortunately, it doesn't include a frame. I apologize for the inconvenience. We do offer a variety of full-size beds that I would recommend you review for something that meets your needs. Thanks for shopping with us.
Shopping Tips & Inspiration
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How to Select a Box Spring
How to Select a Box Spring from Overstock.com. As the foundation of the bed, your box spring can be just as vital to the comfort of your mattress set as the mattress.
How to Choose Mattresses for Children
How to Choose Mattresses for Children from Overstock.com. Here is some advice on choosing mattresses for kids.
Mattresses Buying Guide
Mattresses Buying Guide from Overstock.com. Learn about the different types of mattresses that are available and find just the right bed to get your best sleep ever.
How to Buy a Mattress
How to Buy a Mattress from Overstock.com. With a good mattress, you'll wake up rested and feel better throughout the day. Here's what you need to know about choosing the best mattress.
Tips on Buying a Memory Foam Mattress
Tips on Buying a Memory Foam Mattress from Overstock.com. What should you look for when evaluating different memory foam mattresses? Here's what you need to know when you're shopping for memory foam.
How to Fluff a Pillow-Top Mattress
How to Fluff a Pillow-Top Mattress from Overstock.com. Learning how to fluff a pillow-top mattress is a breeze, and once you know how to do it, you'll never fear a deflated pillow-top again.
How to Choose a Serta Mattress
How to Choose a Serta Mattress from Overstock.com. Serta is one of America's most strusted mattress brands. Here's what to look for when you're shopping for a Serta mattress.
How to Select a Mattress Set
How to Select a Mattress Set from Overstock.com. People spend anywhere between six to nine hours each day in their beds, making it one of the most used pieces of furniture in any home.
How to Protect Your Mattress
How to Protect Your Mattress from Overstock.com. Our guides provide customers with information about how to protect your mattress and advice about our many brand-name products.
Southern Exposure
The desert landscapes and intricate textiles of the Southwestern United States are legendary. Capture the iconic western style in your home with Navajo patterns, animal head decor, and desert plants.
Modern Geometry
Shapes are here and they're making a scene in the modern home. Draw in wandering eyes with geometric rugs, lamps, and furniture. You'll make the decor grade, even if math wasn't your favorite subject.
Connect The Dots
Seeing spots? That's okay, because you're not the only one. Polka dots are a charming way to bring energy to your decor as well as your wardrobe. Go ahead and embrace those little spots.
Retro Revival
The 1950s were a time of swinging tunes, mid-century furniture, and innovative fashion. We're looking fondly to the days of jukeboxes and soda shops for design inspiration.
Wedding Bells At Pride Parade
"It's not just gay marriage, to us it is marriage. Whether it's gay, straight, lesbian, or anything in between, every person should have the right to marry whomever they want and to be happy."
Shipping & Returns
1-4 week delivery after the item ships:**
Delivered by freight carrier. See Oversized Item Delivery Policy.
Mattress Return Policy:
Mattress Sets are non-returnable upon signature at delivery. Mattresses are
non-returnable if opened or taken out of their plastic wrapping.
More Details
This item cannot be shipped to Alaska or Hawaii. More details
Oversized Item Delivery Policy:
This item will be shipped via freight carrier to your home,
excluding rural routes, remote
areas not in close proximity to areas commonly serviced by
freight carriers, islands,
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In the past scientists have warned that up to five per cent of species are at risk of dying-out as a result of climate change, deforestation and development.
But a new analysis by the University of New Zealand found that this figure was five times greater than reality because the number of animals living in the wild in the first place had been over estimated.Read more »
If you're the owner of an ice cream stand in Massachusetts and you make building improvements without asking the state for permission, you may find yourself on the receiving end of a prohibition-style shutdown.Read more »
But while administration officials have long said they prefer Congress take action on climate change, the economic official who spoke with reporters Tuesday night made clear that the EPA will not wait and is prepared to act on its own.
And it won't be pretty.
"If you don't pass this legislation, then ... the EPA is going to have to regulate in this area," the official said. "And it is not going to be able to regulate on a market-based way, so it's going to have to regulate in a command-and-control way, which will probably generate even more uncertainty."Read more »
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Patient Assistance
Support Groups
Oncology Rehabilitation
Survivor School
Concert of Hope and Remembrance
Girlfriend's Tea
Our Needs
Wall of Hope
Verandah Society
Special Events
About Us
Contact Us
Monthly Newsletter
Learn Healthy Survivorship at
CAA Survivor School!
Women who have recently completed treatment for any type of cancer or who are in maintenance treatment can enroll in one of our six-week sessions. The Survivor School classes will be taught by various integrative medicine professionals, Cancer Association and AnMed Health staff who specialize in working with cancer patients -- and even former patients who have walked the same path. In fact, about a third of our team of instructors are made up of cancer survivors!
If you are interested in learning more about the mind-body connection to health and wellness taught at Survivor School, contact Carrie Rozakos Binnicker at 222-3500 or email
for more details or to enroll.
We have an exciting line-up for our next Survivor School this fall. Shannon Carney from Wind River Cancer Welness Retreats and Programs will be speaking to us about the mind/body connection for our first session. You don't want to miss her! We will also take a field trip to Kitchen Emporium to learn about nutrition and how to make some yummy shakes and juice bombs! Come and find out what your "new normal" is after
cancer treatment ends -- or how to keep going if you have metastatic disease. Learn how to be your best "you" at Survivor School! The 6-week series of classes for women survivors covers such issues as nutrition, spirituality, sleep and the importance of laughter (above). Eligible women have completed treatment for cancer in the past year, will be completing treatment soon, or are in a long-range treatment protocol. Survivor School classes are offered at no charge thanks to a grant from the Palmetto Peloton Project Challenge to Conquer Cancer. Call Carrie at 222-3500 or email
to enroll now!!
Cancer Association of Anderson
215 East Calhoun Street
Anderson, SC 29621
Phone: 864-222-3500 Fax: 864-222-3502
CAA is not affiliated with or supported by the American Cancer Society.
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Website: http://www.companioncare.co.uk/harlow
Tel: 01279 770 104
Companion Care Vet Surgery
Inside Pets at Home
St James Retail Park
Edinburgh Way
Essex CM20 2SX
Reviewed by: Topher on 06/07/2015
Overall rating:
I rarely if ever leave comments on social media pages, but I feel compelled to do so this time. I have been to many vets in my life, and I have to say that the service I received from Companion Care in Harlow was absolutely outstanding from start to finish. My dog suffered a very bad broken leg recently after being hit by a car. We arrived at the surgery in utter distress. The staff were extremely helpful and comforting all the way through. Our dog was seen as immediately and the vets were amazing at dealing with his injuries, and we were kept fully informed throughout. Pain relief, X-rays and support splints were placed that very same day to allow the orthopedic vet to plan how he was going to fix the break. The surgery happened a few days later and they did a fantastic job, and our dog now seems back to his normal self.Our family cannot thank you enough!!!!
Reviewed by: Amanda on 19/06/2015
Overall rating:
Reviewed by: Cee on 04/09/2014
Overall rating:
So my dog done an escape trick today so after calling around I get the details for the dog warden and my dog is there.
I find out that my dog was taken in too pets at home Edinburgh way harlow where he is registered the staff don't do anything other than call the dog warden.
The dog is actually one of there patients and is microchipped too!!!
On calling them to ask why they did not contact me I'm told we did what was best for the animal. I have only been with them 3 months and was horrified the woman on the phone began to lecture me on how to ensure the dog does not get out again well sorry but I have a black lab and he got out of a cat flap which he broke to get out so avoid this vets at all costs staff are rude and don't really care one bit.
We are very happy to take in stray dogs to attempt to reunite them with their owners. However, unless a pets microchip registration information is kept up to date with the national database or indeed given to us upon registration of a pet with us, we would be unable to contact the owner. In these circumstances, transfer of the dog to the local dog warden has the highest chance of a successful reunion, but unfortunately does incur a cost due to the council upon retrieval.
We urge every client registering with us to provide us with their pets microchip number or to have one implanted if this has not been done previously. We also strongly encourage anyone with micro chipped pets to update their national database registration if they move or change phone numbers.
Reviewed by: Maggs on 19/05/2014
Overall rating:
I have written a review on a local social media site called "Love Your Doorstep Harlow", to say how good you all are, in particular Garrick (the Vet) who has gone over and above the call of duty researching and investigating the problems my dog is suffering from - even in his own time I suspect - here is what I wrote:-
I have just moved to Harlow and thought I would let you know how impressed I am with Companion Vets 01279 770104 (the vets in the Pets At Home store). I saw a vet called Garrick a couple of times with my dog who has Cushing's Syndrome and he and the nurses are wonderful. They have gone out of their way to help my little Shih Tzu and have discovered another problem she has which my other vet had overlooked. I took her there with an ear and eye infection and they have helped her so much. I was really worried that I wouldn't find a vet as good as my original one, well I have!!
Reviewed by: Karen on 18/04/2014
Overall rating:
The team at Harlow have been amazing with our cat Darcy. Garrick the vet kept us well informed when Darcy was an in patient and the nurses looked after him well. Thank you for looking after him so well.
Reviewed by: smokey on 18/04/2014
Overall rating:
I needed top take my cat for consultation after she had been poorly for 3 days & I couldn't have had better care for both myself-very anxious!--& my cat.
I would recommend this practice to any animal lover
Reviewed by: Chris on 15/04/2014
Overall rating:
Have been a client for some time now and all of my pets recieve the very best of care. The staff are always interested and friendly. They offer me great service. I know I can always talk to them and ask even the silliest questions, they have endless patience. Can't recommend them enough.
Reviewed by: JP on 09/02/2014
Overall rating:
Visited the practice a few times in the past few weeks and have always received great service and professional advice. Highly recommended.


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Training for Testing HTML for 508 Compliance
This module will focus on testing a page that uses scripting languages to display content or create interface elements.
The section 508 requirement covering this is: §1194.22 (l) When pages utilize scripting languages to display content, or to create interface elements, the information provided by the script shall be identified with functional text that can be read by assistive technology.
What accessibility problems can scripts cause?
Web page authors have a responsibility to provide script information in a fashion that can be read by assistive technology (AT). When authors do not put functional text with a script, a screen reader will often read the content of the script itself in a meaningless jumble of numbers and letters. Although this jumble is text, it cannot be interpreted or used.
Scripts can either enhance the aesthetics of a page or affect the page's functionality. This training focuses on the kind of scripts that affect the functionality by displaying content or providing interactive objects, such as buttons, on the page.
Remember, both testers and developers can use the checkpoints for this requirement to be sure the products they are working with will be accessible to users of Assistive Technology (AT).
Use the link above to look at the checkpoints now. You may wish to keep the window open as a reference to use as you complete this module.
To view part one of an approximately two and one-half-minute video with additional information about Scripts which may be helpful to testers and developers, select the video link below. The video will open in a new window; if you are using a screen reader to take this training, press enter when you hear, "To start, press Play button."
Select Next for an Example.
Topic Menu: | Introduction | Example | Testing with AT
Testing without AT | Summary
VA Home |
Privacy |
Regulations |
Web Policies |
No FEAR Act |
Site Index |
USA.gov |
White House |
National Resource Directory |
Inspector General
U.S. Department of Veterans Affairs - 810 Vermont Avenue, NW - Washington, DC 20420
Reviewed/Updated Date: July 1, 2010


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Run Course Summary:
This flat run is a combination of on and off road but entirely inside the Warhill Sports Complex. There will be an aid station approximately every mile and porta potties. This is a great spectating course, offering people many opportunities to cheer on their athletes. The Olympic consists of 2 loops while the half consists of 4 loops. The first 2-miles are on the WISC trail system which is a wide, rolling hardpack trail, a favorite running location for local runners including the Nationally ranked William&Mary Cross Country team. The final mile-plus of the loop is a slight uphill on an asphalt running path leading back up to T2 and Wanner Stadium. The multi-loop course will give spectators ample opportunities to cheer on their favorite athletes.
Run Course Markings:
The Olympic Run course will be marked with YELLOW signs and YELLOW duct tape arrows on the ground. There will be a progression of duct tape arrows on the ground before every turn and then a progression of duct tape arrows on the ground after every turn.
The Half Run course will be marked with ORANGE signs and ORANGE duct tape arrows on the ground. There will be a progression of duct tape arrows on the ground before every turn and then a progression of duct tape arrows on the ground after every turn.
Run Course Rules and Regulations:
Permitted Conduct. A participant must run or walk the entire portion of the run course. Except for reasons of safety and when no advantage is gained, all runners shall follow and remain within the prescribed course. A participant who gains forward progress by crawling or otherwise violates this Section shall be disqualified.
6.2 Knowledge of the Course. The responsibility of knowing and following the prescribed course rests with each participant.
6.3 Permitted and Illegal Equipment. Any participant who at any time wears or carries a headset, radio, headphones, personal audio device, or any other item prohibited by Section 3.4(i) shall be subject to a time penalty. A participant may carry a water bottle on the run portion of the course, provided that such container is not made of glass. Glass containers are prohibited.


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Haddock In Spanish Salsa Verdi
700 grams Haddock fillet, (1 ½lb)
1/2 teaspoon Fennel seeds
1 tablespoon Plain flour
30 grams Butter, (1oz)
285 ml White wine, (10fl oz)
85 ml Double cream, (3fl oz)
3 tablespoons Fresh flat leaf parsley
3 Anchovy fillets
225 grams Frozen petit pois, (8oz)
In a saucepan over a medium heat, fry your garlic in the butter and oil until golden. Add the fennel seeds and give a stir and then add two thirds of your chopped parsley. Fry it until it all goes a darker, translucent green, stirring all the time. Take off the heat and add the anchovies, stirring and mashing them into the oil. Now over a low heat stir in your flour and cook for 1 minute (as if you're making a white sauce) and add the small peas. Add the cream to the sauce and sea
Now add the sauce to the pan, and gently simmer for a further 2 minutes.
1.0 servings
Friday, December 10, 2010 - 1:02am


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5 Reasons The Minnesota Vikings Will Win (Greg Whitt)
1. It looks like Christian Ponder may have finally figured out how to pass the ball for more than five yards a clip. While he didn't exactly put up Drew Brees numbers in terms of yardage, he did complete some nice deep balls last week that he hasn't been able to connect on earlier this season.
2. Last year the Packers went down to a seemingly inferior team in the first round of the playoffs. With some up and down play this year, I'm not sure that this Green Bay squad has fully exorcised those ghosts of failures past.
3. Expect Jared Allen and the Minnesota front seven to keep Aaron Rodgers on the run and unable to set his feet to make big throws against the Vikings secondary. The Vikings are fifth in the league with 44 sacks this year, five of which came last week in a victory versus the Packers who have allowed the most sacks this season.
4. Momentum is in the Vikings favor after pulling out a big, emotional, win last week.
5. The Vikings have an angry rhinoceros in football cleats by the name of Adrian Peterson. Expect him to receive close to 30 carries, and rush for 175 yards.
Final Score: 28-24, Vikings


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Apple has introduced a new version of their web browser, Safari 4. Some new features include Top Sites which displays your most visited websites with a neat perspective design and cover flow in your favorite sites.#19238
These are the first images ever taken of the acropinna microstoma or "Barrel Eye" fish. It's head is transparent so it can look up see through it's "dome."#19231
Designers Niels Van Eijk & Miriam Van der Lubbe have created these fun flower vases. They have a resevoir in which to hold the water and various holes so you can design your 'boy' or 'girl' in infinite floral dress.#19220
"half awake and half asleep in the water" a beautiful series of photos by Asako Narahashi.#19218
Gregory Euclide's relief paintings are unconventional to say the least! I've never seen anything like them. [Editor's Note: his older works were seen as #984]#19210
Street artist ABOVE just updated his website after a 24-month hiatus. This street artist has so many interesting concepts, and mediums and stories to tell. Make sure to check out the Travel Photo section as well.#19206
A simple but straight to the point graphic by Dan Meth. Do you agree with his opinion of these trilogies?#19203
Swedish designer Monica Förster has designed the worlds first office chair for women. The chair is a result of a lengthy study on female sitting posture.#19200
A book showcasing Pentagram's often-iconic identity work. Also "printed on French-folded bible paper, bound in a red, cloth-covered softback cover and includes five ribbons for bookmarking".#19196
Various Architects designed this stunning diamond-gridded eco pavilion for the Yorkshire Forward. The inflatable event space is ultra-portable, generates all of its own energy, and is 100% recyclable#19195


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Dads' Brilliant 'Frozen' Parody Is the One You've Been Waiting For
We know, we know -- 'Frozen' parodies are nothing new. But even after all this time, there are still some clever ones to enjoy.
We know, we know -- 'Frozen' parodies are nothing new. But even after all this time, there are still some clever ones to enjoy.
Peyton Blake Farrell (Farrell? Kind of like Pharrell?) isn't even 2 years old, but he sure can dance up a storm.
This is otter-ly amazing. These otters at Smithsonian's National Zoo show off their skills on a keyboard.
Somebody made a website to figure out what song your parents were listening to when they made you.
We don't want to waste too many words on this. Because really, all you need to do is watch the above clip.
The father and daughter lip-sync of Iggy Azalea's 'Fancy' has amazing written all over it! They nail it!
Wedding season is upon us, but we already have a winner for best nuptials of the year.
Maracas in May is proudly sponsored by Jose Cuervo and presented by Corona. Additional Maracas sponsors include Coyote Blues, Crescent Crown, La Carreta, Legends Downtown & Annex, Marley's Sports Bar, Schlotzsky's Lafayette (both locations) and Swamp Vapor.
T.I. and DJ Toomp are one of the deadliest duos in rap. Over the last decade, the Atlanta pair have fed the streets with heaters like '24's,' U Don't Know Me' and 'What You Know.' Tip and Toomp have linked up once again on this new cut called 'Turn It,' and it doesn't disappoint.
Mase is back with a bouncy new record, 'Nothing,' featuring crooner Eric Bellinger.


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COLUMBIA, Md., Nov. 11, 2010 /PRNewswire-FirstCall/ -- Celsion Corporation (Nasdaq: CLSN), a leading oncology drug development company, today announced that the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA) has issued a positive opinion on the application for Orphan Drug Designation for ThermoDox®, a proprietary heat-activated liposomal encapsulation of doxorubicin, for the treatment of hepatocellular carcinoma (HCC), commonly referred to as primary liver cancer. A positive opinion by the COMP immediately precedes official designation of ThermoDox® as an orphan drug by the EMA. ThermoDox® is currently being evaluated under a Special Protocol Assessment with the FDA in a 600 patient pivotal Phase III trial (the HEAT study) in patients with non-resectable primary liver cancer at 76 clinical sites in 11 different countries. ThermoDox® has previously received Orphan Drug designation by the U.S. Food and Drug Administration (FDA). In addition, the HEAT study has been designated as a Fast Track Development Program by the FDA.
Orphan designation for a medicinal product by the EMA provides for scientific advice and regulatory assistance from the EMA during the product development phase, direct access to centralized marketing authorization, and certain financial incentives. The designation also provides 10 years of marketing exclusivity subsequent to product approval. Orphan drugs are eligible for full reduction of fees associated with pre-authorization inspections, as well as full reduction of marketing application fees and annual fees for qualifying companies.
"We are very pleased to receive a positive opinion from the Committee for Orphan Medicinal Products, which immediately precedes final Orphan Drug designation from the EMA, for ThermoDox®," stated Mr. Michael H. Tardugno,
|SOURCE Celsion Corporation
Copyright©2010 PR Newswire.
All rights reserved


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Thomas Content offers insight on changes in the world of energy, climate change and efforts to build a greener economy.
Magnetek gets $11M order for wind inverters
Magnetek Inc. said Tuesday it has received an $11 million order for wind power inverters used to help send electricity generated by wind turbines to the power grid.
The Menomonee Falls company said the follow-on production order for wind power inverters will result in shipments to Magnetek's customer between December and November 2010.
The company's wind inverters regulate and transform DC power generated by wind turbines into AC power that can flow along transmission lines.
"We believe renewable energy provides growth opportunities for Magnetek," said Peter McCormick, chief executive officer. "We look forward to fulfilling this order for our customer, as we continue to work on the development of additional advanced power conversion solutions for both the wind and solar markets."
In the fiscal year that ended June 28, Magnetek posted sales of $98.2 million, down 2% from $100 million in the prior year. Net income was $3.3 million or 11 cents per share, down from $10 million or 33 cents a share in the prior year.
Magnetek serves the material handling, elevator and alternative energy markets.
Comments »
Read and share your thoughts on this story.


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Nursing Symposium: Feb. 16
Pre-Con Symposia: Feb. 16
Sessions: Feb. 17-19
Los Angeles, Calif.
Join or renew your AHA/ASA Professional Membership today to save on registration
for all AHA Scientific Sessions.
Registration for 2016 opens in October!
Late-Breaking Science and Ongoing Clinical Trials Submission Now Open!
Deadline: Nov. 4, 11:59 p.m. CT
This deadline will not be extended.
Additional Information
Late-Breaking Science and Ongoing Clinical Trials Abstract Submission is now open!
Be a leader in the fight against stroke! Submit your science for the International Stroke Conference 2016.
In order to encourage a broad range of science and speakers, international authors and junior authors are strongly encouraged to submit abstracts for presentation.
Looking for ISC 2015 Information? Visit our archives!
Be a catalyst in the fight against stroke! Save the date for the world's premier educational event dedicated to the science and treatment of cerebrovascular disease - the International Stroke Conference 2016, to be held February 17-19, 2016 in exciting Los Angeles, California!
This 2½-day conference provides the opportunity to network with almost 4,400 cerebrovascular experts representing over 60 countries; it offers outstanding programming that delivers more than 1,500 compelling presentations in 21 categories emphasizing basic, clinical and translational sciences as they evolve toward a more complete understanding of stroke pathophysiology with the goal to develop more effective prevention and treatment. Maximize your conference experience by attending one of the three exciting pre-conference symposia:
The International Stroke Conference - connecting the world to stroke science.
ISC Archives


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The Digital Community dedicated to the best of Silicon Valley and Madison Avenue
Film News: Scott Stuber, Madhouse will produce
Original post:
Universal wins 'Black Box' bidding war
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Talk NYC/WW is your daily download of the tech, marketing and advertising news you need to know. It's smartly curated to keep you up to speed on the innovators and innovations that are shaking up the digital world today.


text:
Application Instructions
Applying to the Summer Institute is easy! Follow the instructions below to submit your application today. For questions, please contact the Office of International Initiatives at email@example.com.
- March 1: Submit your application, Intent to Register form, and Registration Agreement form to the Office of International Initiatives at email@example.com.
- *Reminder: Apply for a passport (if you don't already have one).
- March 15: Pay $450 deposit online at http://gsu.peertransfer.com. Note: in order to pay your deposit online, you need your Georgia State student ID #. You will receive this after your application has been processed by our Admissions team.
- April 1: Submit financial documents to Georgia State's International Student & Scholar Services (ISSS) office. Download the International Applicant Immigration form and the International Applicant Financial Information form to begin this process (forms will be available soon). You can also visit the ISSS site for more information on applying for an F-1 student visa.
- June 1: Submit Certificate of Immunization form to the Office of International Initiatives at firstname.lastname@example.com.


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The Floaters
The Floaters were an R&B vocal group from Detroit, Michigan, USA, that formed in 1976. The band was formed by the former The Detroit Emeralds' singer James Mitchell, with his brother Paul Mitchell, Larry Cunningham, Charles Clark, and the unrelated Ralph Mitchell. Their only top hit, "Float On", was written by Arnold Ingram, Marvin Willis and James Mitchell Jr., and produced by Woody Wilson. It became a world wide hit in 1977 on ABC Records, reaching #1 on the U.S. R&B chart, #2 on the U.S. Billboard Hot 100 chart, and #1 in the UK Singles Chart (for a single week in August that year).
No stations playing The Floaters now
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Float like a flower petal on a fresh breeze by donning this darling jade-green party dress! The A-line silhouette of this stretch-knit frock is accented by sheer, white lace panels at each shoulder, framing the collar with dainty crocheted posies. Spin around in the pleated mini and savor its invigorating style!
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Personalized Diagnostics and Targeted Therapies
The Philadelphia Chromosome provided the first evidence that genetic abnormalities were linked to cancer. This discovery at Penn more than 50 years ago ushered in the modern period of cytogenetics. Now, the Center for Personalized Diagnostics (CPD), founded in 2012, builds on this legacy and is set to pave the way for a new era of genomic and therapeutic pathology.
The CPD is a collaboration between the Abramson Cancer Center and the Department of Pathology and Laboratory Medicine and offers four core components to physicians and researchers:
- A CAP/CLIA certified clinical laboratory for high throughput, next-generation DNA sequencing and other genomic analyses to provide diagnostic tests to clients within and beyond Penn Medicine
- A clinically oriented research group with a focus on developing new tools for personalized diagnostics, new methods for data analysis, particularly of the large volumes of data derived from massively parallel "-omics" technologies, and on collaborating to gather data correlating diagnostic information with patient outcomes
- A test development laboratory for generating additional clinical diagnostic tests that fall within the realm of personalized medicine in order to translate research into the clinical environment
- A clinical and translational education service for trainees as well as established pathologists and clinicians to guide them through this highly complex, rapidly evolving field and to aid in the understanding and implementation of genomic medicine
Current Test Panels
Cancer is fundamentally a disease of the genome. Genome-guided mutation detection can empower the medical oncologist to select cancer treatment therapies specific for tumors harboring these mutations. While a mutation may only be detected in a small subset of individual cancers, taken together, these mutations are not rare and specific molecular changes exist in all cancers.
The Center for Personalized Diagnostics currently offers two different cancer gene-sequencing panels:
- A custom hematologic malignancy panel, focused primarily on AML, MDS and CLL
- A more comprehensive solid tumor panel, containing 47 genes known to be mutated in a wide range of tumor types
Custom Hematologic Malignancy Panel
The primary focus of the first version of the hematologic malignancy panel is on acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and chronic lymphocytic leukemia (CLL). The AML, MDS, and CLL targets were chosen because of the extensive data in the literature on the molecular characterization of these tumors. Within this panel, there are genes that are:
- Predictive of outcome (for example, NPM1, IDH1 are good prognostic markers)
- Useful for chemotherapy decisions (for example, DNMT3A mutation detection can direct Daunorubicin dosage)
- Able to identify mutations linked to targeted therapies (ABL1 amplification and treatment with Imatinib, BRAF mutations and treatment with Vemurafenib)
- Not responsive to treatment (for example, ASXL1 is associated with a very poor outcome with conventional treatments). In such instances, tests may help determine if there are clinical trials that would be more useful
Taken together, the information provided by the sequencing of large panels has the potential to modify the diagnosis, with subclassification of the tumor or detection of secondary underlying malignancies, by yielding an oncologic profile based on the underlying genetic changes.
In turn, these characteristics will allow oncologists to integrate their knowledge of the patient with the disease, mutation profile and other laboratory testing to establish a personalized treatment plan for each individual patient.
Comprehensive Solid Tumor Panel
The vast majority of cancers are solid tumors, that is, non-hematological (blood or bone marrow) malignancies. Solid tumors typically present as a mass of cancer cells either within a specific organ or throughout the body as metastases.
Virtually every organ in the human body can develop cancer. Solid tumors can be difficult to treat if they are metastatic or inoperable. Because of this, the genetic characterization of tumors through personalized diagnostics can be extremely useful in determining the appropriate chemotherapy.
For example, lung cancer has revealed a wide range of genetic changes that have helped clinicians to treat subsets of their patients with targeted, individualized therapies.
First, mutations in the epidermal growth factor receptor (EGFR) were detected in approximately 15-20% of patients with adenocarcinoma of the lung. A targeted cancer therapy, Gefitinib or Erlotinib, can be selected by medical oncologists as a specific treatment option for patients with this mutation. More recently, chromosomal rearrangements of ALK and ROS1 in adenocarcinomas of the lung have been identified in small subgroups of patients, who can be treated with Crizotinib.
At the same time, there are many additional genetic mutations in lung cancer that occur in low percentages of individuals, but for which targeted therapies exist—including ERBB2 (Trastuzumab), BRAF (Vemurafenib), and PIK3CA (currently multiple inhibitors in clinical trials).
The ability to diagnose the underlying architecture of a tumor through massively parallel genome sequencing means that a single test can profile the tumor for all its known actionable and prognostic markers.
Translational Test Development
As the genomic revolution continues to uncover novel mutations in a variety of biological genes and pathways, the Center for Personalized Diagnostics (CPD) is actively engaged in new test development and is prepared to add new clinically useful markers to future versions of gene panels for both leukemias and solid tumors.
Additionally, validation is underway to expand sequencing to the entire coding region of the genome (exome) in order to identify truly personal mutations that may be affecting key biological pathways.
Research Center
The CPD will also serve as a cancer research center to detect clinical correlations for treatment and outcome, with the goal to identify prognostic markers for future diagnostic and treatment options. Interested researchers should contact the CPD technical director.
The CPD Team
The concept of cancer as a genomic disease has been clear since 1960, when Peter Nowell, from the University of Pennsylvania, and his graduate student David Hungerford identified an abnormal chromosome (the Philadelphia chromosome) associated with chronic myelogenous leukemia (CML). Amazingly, the first targeted therapy for cancer, Imatinib, was later developed around the Philadelphia chromosome and its targeted fusion gene product BCR-ABL1 as well.
Targeted therapy can be categorized into small molecules and monoclonal antibodies. Small molecules are chemicals that block the growth of cancer cells, often by mimicking a substrate, which blocks the active site in the molecule. Some examples of small molecules in cancer include imatinib mesylate (Imatinib), commonly used for CML, gastrointestinal stromal tumors, as well as some other tumors and erlotinib and gefitinib, which are targeted against EGFR mutations in lung and pancreatic adenocarcinomas.
There are also monoclonal antibodies that target specific genetic changes in tumor cells. An example of a monoclonal antibody that has altered disease outcome is trastuzumab, which targets ERBB2 (also known as her2/neu) that is expressed in some breast cancers and some lung adenocarcinomas. The promise of trastuzumab as a targeted therapy that can both treat advanced cancer and prevent its development or reoccurrence traces its origins to the pioneering contributions of Dr. Mark Greene, now a University of Pennsylvania faculty member in the Department of Pathology and Laboratory Medicine. The Center for Personalized Diagnostics at the University of Pennsylvania builds on this legacy of personalized medicine.
Current Leadership
Kojo Elenitoba-Johnson, MD
Director, Center for Personalized Diagnostics
Kojo Elenitoba-Johnson, MD, is the Peter C. Nowell, M.D., Professor in the Department of Pathology and Laboratory Medicine and the Director of its Molecular and Genomic Pathology Division. Dr. Elenitoba-Johnson received an MD from the University of Lagos College of Medicine in Lagos, Nigeria. He completed residency training in Anatomic and Clinical Pathology from Brown University School of Medicine, Providence, Rhode Island. Following residency training, he completed a Hematopathology Fellowship at the National Cancer Institute, where he trained with one of the world's leading lymphoma pathologists, Dr. Elaine Jaffe.
Prior to coming to Penn, Dr. Elenitoba-Johnson was a member of the faculty of the University of Michigan Department of Pathology, which he joined in 2006 as Assistant Professor and Director of the Division of Translational Pathology. In 2009 he was promoted to the rank of Professor and held the Henry C. Bryant Professorship. He was also the Director of the Molecular Diagnostics Laboratory.
Jennifer Morrissette, PhD
Clinical Director, Center for Personalized Diagnostics
Dr. Morrissette is a dually board certified clinical molecular geneticist and clinical cytogeneticist through the American Board of Medical Genetics (ABMG) and the Scientific Director of the Clinical Cancer Cytogenetics Laboratory in the Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania.
She received her PhD in Molecular Genetics from the State University of New York at Buffalo and completed a Postdoctoral Fellowship in Molecular Genetics at Harvard Medical School and a Fellowship in Clinical Cytogenetics at The Children's Hospital of Philadelphia.
Robert Babak Faryabi, PhD
CPD Faculty Lead, Bioinformatics
Dr. Robert Babak Faryabi is an Assistant Professor of Pathology and Laboratory Medicine and a member of the Abramson Family Cancer Research Institute. After a postdoctoral training with Dr. Andre Nussenzweig at the NIH Laboratory of Genome Integrity, Dr. Faryabi joined the Perelman School of Medicine at the University of Pennsylvania in June of 2015. The focus of his lab is to explore the genome-wide signatures of replicative stress and the contributions of replication stress-induced genomic lesions to hematological malignancies. To achieve this goal, the lab employs a combined experimental-computational approach, and develop computational methods based on combinations of big data analytics, mathematical modeling and machine learning algorithms to integrate and interrogate high-dimensional experimental data sets.
CPD Staff Members
- Alan Fox
Technical Supervisor
- David Lieberman
Genetic Counselor
- Shrey Sukhadia
Bioinformatics Specialist
- Jianhua Zhao, PhD
Molecular Genetics Fellow
- Patrick Candrea
Medical Technologist
- Karthik Ganapathy
Medical Technologist
- Joe Grubb
Medical Technologist
- Barnett Li
Medical Technologist
CPD Resources and Selected Publications
- Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R. Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer. Anticancer Res. 2015 May;35(5):3007-12.
- Kenderian SS, Ruella M, Shestova O, Klichinsky M, Aikawa V, Morrissette JJ, Scholler J, Song D, Porter DL, Carroll M, June CH, Gill S. CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia. Leukemia. 2015 Feb 27. doi: 10.1038/leu.2015.52
- Loaiza-Bonilla A, Clayton E, Furth E, O'Hara M, Morrissette J. Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine. Ecancermedicalscience. 2014 Nov 6;8:479. doi: 10.3332/ecancer.2014.479
- Sehgal AR, Gimotty PA, Zhao J, Hsu JM, Daber R, Morrissette JD, Luger SM, Loren AW, Carroll M. DNMT3A mutational status affects the results of dose-escalated induction therapy in acute myelogenous leukemia. Clin Cancer Res. 2015 Jan 21. doi: 10.1158/1078-0432.CCR-14-0327
- Wilson MA, Morrissette JJ, McGettigan S, Roth DB, Elder D, Schuchter LM, Daber RD. What you are missing could matter: a rare, complex BRAF mutation affecting codons 599, 600, and 601 uncovered by next generation sequencing. Cancer Genet. 2014 Jun 18. pii: S2210-7762(14)00136-7
- Azzato EM, Morrissette JJ, Halbiger RD, Bagg A, Daber RD. Development and implementation of a custom integrated database with dashboards to assist with hematopathology specimen triage and traffic. J Pathol Inform 2014;5:29
- Wertheim GB, Daber R, Bagg A. Molecular Diagnostics of Acute Myeloid Leukemia: It's a (Next) Generational Thing. J Mol Diagn. 2013 Jan;15(1):27-30. doi: 10.1016/j.jmoldx.2012.08.002
- Zhang L, Znoyko I, Costa LJ, Conlin LK, Daber RD, Self SE, Wolff DJ. Clonal diversity analysis using SNP microarray: a new prognostic tool for chronic lymphocytic leukemia. Cancer Genet. 2011 Dec;204(12):654-6. doi: 10.1016/j.cancergen.2011.10.012
- Segal JP, Aikawa V, Daber R, Morrissette JJ. Array Cytogenomics as a Diagnostic Aid for Acute Myeloid Leukemia: A Comparison of Four Different Platforms. Association for Molecular Pathology, Annual Meeting Abstracts. J Mol Diagn. 2011 Nov;13(6):730. doi: 10.1016/S1525-1578(11)00254-6
- Download AMP Meeting Abstract (PDF)
Related Links
Questions & Information:


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Join Le Wood
Update Notes
Updated on: 02/23/2015
Since we last visited LeWood...
- You get over 100 more videos (60 more photo sets) and they're updating even more frequently than before.
Le Wood sounds like the name of a French porn site dedicated to men's erections. However, it's a cleverly named site from Evil Angel directors - and married couple - Francesca Le and Mark Wood.
I didn't watch every single scene, but from what I could tell, each features either Francesca or Mark, or both of them, and they're all hardcore. One scene had them fucking a teen hottie who had found their "box of toys" and teaching her a lesson about not snooping. Regardless of whether they're working with another performer or not, you can't help but be transfixed by their alluring chemistry.
From there I moved on to watch Mark bang a horny MILF and in another scene Francesca used her hot Latin body to seduce her "daughter's boyfriend." Oh, and every scene I watched also focused on anal sex.
The design is nice and navigation is a breeze (they changed up the color-scheme since our last visit). When you sign in you'll be looking at a page of the latest videos, with a menu at the top and a category list along the side. Each video comes with content tags and linked performer names and you can add scenes to your favorites and rate them out of five stars.
There have been 17 new movies in the last 30 days alone (the photo sets aren't dated) and as I look at the site right now there are 452 photo sets and 567 videos and those numbers are only going to be higher by the time you get to it.
You can download the high-res pics in handy Zip files and many of the movies come in Full HD when downloaded in the MP4 format. There's a good-quality Windows Media file as well and the ability to stream them win an embedded player. I recommend streaming one video while you download one or two others, but that's just how I like to roll.
Since the amount of content is good, you might not think you need bonus sites. But even if you don't need them it doesn't mean you shouldn't have them, right? Well, your membership also gets you access to all the Evil Angel sites, including Joey Silvera, Christoph Clark Online and Gaping Angels.
The network is an easy recommendation and given how much main content there is and how often they're adding new porn it's pretty easy for me to say that Le Wood is a hardcore porn site worth joining.
* Please include a pro and a con about the site. Balance is essential in making a comment worthwhile. Scores without comments will be deleted.
* Watch out for ratings of zero and 100. In our opinion, there is no such thing as a site that is absolutely perfect or completely worthless.


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From the designer's 'Evil Eyes' collection, Ileana Makri's iconographic necklace is inspired by her rich Greek heritage. Strung on an 18-karat white gold chain, this sparkling charm is studded with diamonds and sapphires. Said to act as protection from negative forces, wear yours everyday as your signature talisman.
18-karat white gold Sapphires, total weight: 0.12-carats; black and white diamonds, total weight: 0.21-carats Lobster clasp fastening
Product code: 414490 - Need help? Contact us


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Peppers bartender Valerie Carcia said she's had offers to work Super Bowl parties.
- Filed Under
Valerie Carcia sells trendy women's clothing as a retail sales manager by day.
By night, she's a bartender -- in Indianapolis.
And that happens to be a pretty good gig to have as the Super Bowl -- the nation's party weekend -- makes its way to the city. ...


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Ary Spaans Jan.15,1925 - Nov. 4, 2012 Born in Scheveningen, The Netherlands Ary left us to be with his beloved Lily. Even after Sixty-five years of marriage, he just didn't want to be without her. Life was not easy for them. Living in The Netherlands during World War 2, Ary was picked up by the Nazis and sent to a concentration camp in Horbach, Germany, as a labourer. After his release, emaciated and suffering from TB, pleuritis, and blood dysentery, he somehow made his way back to Holland. No one thought he would survive but he fooled all. In 1952, with 3 children in tow and $90.00 in their pockets, the family landed at Pier 21 in Halifax and took the train across Canada. Ary remembered the kindness of strangers, as fellow passengers got off at various stops and returned with food for the young family, who stayed locked in their seats. Ary had secured a job in Telkwa but an immigration official recommended he stay in Prince George. They lived in a series of shacks and Ary held a succession of jobs as an electrician. With $300.00 saved he started building his own house. It took a few years but he had the Canadian Dream. Ary loved HAM radio but later the internet, Email and Skype provided a connection to the outside world. In the last 10 years, he fought heart attacks, bypass surgery, bladder cancer and prostate cancer, just so he could live and take care of his beloved Lily. Now he can rest. He leaves behind his daughter Irene (Don) and sons Jan and Peter. The family would like to Thank Dr. Mann and Corinne, Dr. Jamieson, the nurses at UHNBC and PG Rotary Hospice. Also a great debt is owed to his close friends and neighbours who stepped into the breach when the family couldn't. Ary hated funerals and just wants you to remember him with happiness and love.
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text: Getty Images [ Bachmann: Romney, Gingrich Both have 'Flaws' By The Associated Press December 6, 2011 Congresswoman Michelle Bachmann is brushing aside polling numbers showing her trailing badly in Iowa, saying "I think we're perfectly situated to be where we want to be." Read More|Comment Category: Political, State/Regional News Tags: Michele Bachmann Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!