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Most admired companies have room for social media improvement
Not all of America's most admired companies are killing it on social media. In fact, some are almost flat lining, according to a team of researchers.
Celebrate Penn State Lehigh Valley's Commencement with #PSULVgrad
Penn State Lehigh Valley is gearing up for commencement on May 9. The campus is once again using #psulvgrad on its Twitter, Instagram and Facebook platforms throughout the weeks leading up to commencement and during the May 9 event to celebrate the festivities.
Online identities to be discussed in lecture at Penn State Behrend
On Wednesday, March 4, Aimée Morrison will discuss how we construct our online identities when she visits Penn State Erie, The Behrend College, for a special presentation.
Morrison's talk, "Researching like a Fan: Doing Partial Scholarship Online," takes place at 4:30 p.m. in the Metzgar Center lobby. It is free and open to the public.
Social media campaign #PSU24 to showcase a day in the life of Penn State
Starting at sunrise on Thursday, Oct. 23, a 24-hour social media campaign will chronicle a day in the life of Penn State. Dubbed #PSU24, the campaign seeks to showcase the many moments and experiences that make up a day at Penn State, on campuses around Pennsylvania and at locations around the world.
Students, faculty, staff, alumni and friends are encouraged to contribute using #PSU24 with photos, videos and messages of their Penn State moments throughout the day on Twitter, Instagram, Vine and Facebook.The Penn State Lehigh Valley community is encouraged to participate using #PSULV in addition to #PSU24, so posts can be shared on official campus social media outlets.
Privacy forum organized by media, law groups to be held at Lehigh Valley
Facebook knows everything about you. So does Google. But there are a host of other forces at work to erode what Americans see as a fundamental right of privacy, a phenomenon that leading media and law experts will address at a panel discussion from 2 to 3 p.m. Wednesday, July 16, at Penn State Lehigh Valley (2809 Saucon Valley Road, Center Valley) in the multipurpose room (Room 135). It is free and open to the public.
Medical students may benefit from social media guidance
Medical students use social media extensively, but medical schools may need to offer more guidance in potential pitfalls, according to Penn State College of Medicine researchers.
Faculty speakers series continues with topic of social media dangers
The Penn State Beaver Spring Faculty Speakers Series will continue next month when LaVarr McBride, instructor in administration of justice, presents "How to Avoid the Harms of Social Media," noon, Wednesday, March 14, in room 16, Student Union Building. The program is free and open to the public. McBride will discuss the potential dangers of modern technology and social media, including sharing personal information and photos on the Internet, Facebook, Twitter, texting, cyber bullying, and cell phone use. In addition, he'll discuss the importance of personal responsibility when using social media. McBride can be contacted at firstname.lastname@example.com or 724-773-3866.
Interface could help Facebook members limit security leaks
A sign-up interface created by Penn State researchers for Facebook apps could help members prevent personal information -- and their friends' information -- from leaking out through third-party games and apps to hackers and identity thieves.
Celebrate Social Media Day by joining in the Penn State conversation
Today (June 30) is World Social Media Day. Celebrate with Penn State by joining the conversation with hundreds of thousands of fellow Nittany Lions. With 218,000 fans, Penn State's official page on Facebook is one of the most popular university pages in the world, more than doubling its fan count in the past year. See what other Penn Staters are talking about while enjoying news, photos, videos and more at facebook.com/pennstate. On Twitter, join the thousands who already follow @penn_state for news and discussion and @pennstatelive for a feed of the University's latest news headlines. And check out University photos, videos, professional networking and more.
Penn State Hershey offers 'healthy' Facebook page
The Penn State Milton S. Hershey Medical Center Facebook page now offers easy access to a wealth of health resources, like our Health Information Library, a symptom checker, a drug interaction tool, and a series of wellness tools.
Real-time search market worth more than $30 million a day
All of those Twitter tweets and Facebook friends may have value after all, according to Penn State researchers. Updates on Twitter, Facebook, LinkedIn and other real-time content sites could be worth more than $30 million a day, or nearly $10.9 billion a year, to advertisers, said Jim Jansen, associate professor, information sciences and technology.
Facebook researcher to speak at IST on April 4
Facebook's Rong Yan will present a talk titled "Large-Scale Social Media Analysis at Facebook" at the College of Information Sciences and Technology from 11:15 a.m. to 12:15 p.m. Monday, April 4, in room 113 (the Cybertorium) of the IST Building on Penn State's University Park campus.
Follow the Beaver Valley Area Alumni Chapter on Facebook
Penn State Beaver alumni, friends, and fans now have the option to follow the Beaver Valley Area Chapter of the Penn State Alumni Association on Facebook at http://www.facebook.com/PennStateAlumniBeaverValley. The public is invited to join the alumni chapter. Membership fees are $10 per individual and $15 per family. To visit the alumni chapter's website, go to http://www.beaver.psu.edu and click on "Alumni and Friends." For more information, contact the Beaver campus Office of Campus and Community Relations at email@example.com or 724-773-3816.
Penn State Hershey is now on Facebook and Twitter
Penn State Hershey now has an official presence on Facebook and Twitter. "Like" Penn State Milton S. Hershey Medical Center and Penn State College of Medicine at http://www.facebook.com/pennsthershey or follow us on Twitter at http://www.twitter.com/pennsthershey online.


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Arleen Hunter, Bonita Springs' development services director
- Filed Under
Arleen Hunter, Bonita Springs' development services director, was recently named one of Gulfshore Business Magazine's prestigious 'Forty under Forty' honorees for 2013.
Each year for the past decade, Gulfshore Business Magazine honors 40 professionals younger than 40 who have distinguished themselves in their professional lives and through their service to the community. These are professionals they deem "Southwest Florida's remarkable young leaders."Hunter continues to develop her professional planning skills and was recently elected vice president of financial affairs ...

subset: commoncrawl


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Greatest song ever!!!!!!
Howw do you download? Mannnnn I love this song! I love you AKOOOOOOOON!!!
trouble music, good track
trouble music
Very, very good. Akon hasn't made one like this in a minute, glad to hear he's back. And I usually don't like Wiz, but his short verse here is perfect in terms of the way it fits into the content of the song. 5/5
five stars
havent heard an akon song i liked in a while, 5 stars
good song
Actually really good. Surprised me:)
Nice song; I've missed akon so bad :D "Its a haters job, but somebody gotta' do it!" shout out to all the people that hate on wiz i guess some one has to Do It!! :p 5/5
This comment was removed for violating our sperm and/or vaginal content policies.
Just 1 word (dope)
Kon delivers
i liked it right up until he said 'harry potter'
perfect 5
damn every producer loves those trap snare rolls right now lol. Lex Luger changed the game period. This song is good, I agree a rapper like J.cole would of added something more too it...wasnt feelin Wiz on this. But then again haven't been feeling Wiz alot period.
Nice to hear from Akon! Its been too long. I used to be a big Wiz fan, but as of late his shit has gotten more and more annoying; it's the same repetitive bullshit. Anyway, 5* for Akon and the sick beat.
His lyrics are repetitive as fuck but his flows on point
add j. cole and remove wiz and this would be a #1 chart topper
This song gon be #1 eitherway. its hella dope
The Akon i love should've got sum1 useful instead of wiz
the real akon not that dance pop and shitty music
hearing this song brings me back. niceee
That's what we wanna hear from akon, but wiz is so annoying, useless verse
Loving this Song!Nice work.
Its been so long, feels good hearing his voice again
lol, on the real track is dope.
^^ no h0m0 ?
Damn akon, its been so long
as above
No lie this shits catchy n smoothe AS HELL


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- Filed Under
Victor Martinez, J.D. Martinez and Rick Porcello continue to deliver for the Tigers.
Victor Martinez hit a two-run home run to break a scoreless tie in the fourth inning. After Victor Martinez was intentionally walked with one on and two out in the eighth, J.D. Martinez hit a three-run home run to give the Tigers a 5-0 lead.
Porcello pitched six scoreless innings for the Tigers to earn his 9th win of the season. Porcello allowed six hits and one walk with three strikeouts. ...


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Yeah, you are right, but it aint just business, look at the state of our UK politics (I've already done religion today....and Leicas (same thing)). Is democracy dead in a country of career MP sheep, herded by party whips!
I just pray that Ilford can hold it together for the long haul.


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The sun sets recently over Les Mason State Park, located on the east shore of Whitefish Lake. / TRIBUNE PHOTO/ERIN MADISON
Les Mason State Park, on the east shore of Whitefish Lake, offers a beach, swimming area, picnic tables and a canoe launch. / TRIBUNE PHOTO/ERIN MADISON
Dave Bennetts, park manager at Whitefish Lake State Park, left, enjoys an evening picnic with his wife Cheri, son Henry, 6, and daughter Samantha, 4, at Whitefish Lake State Park. / TRIBUNE PHOTO/ERIN MADISON
The 10-acre Whitefish Lake State Park offers 25 campsites, as well as swimming, boating and fishing. / TRIBUNE PHOTO/ERIN MADISON
Montana State Park Challenge
WHITEFISH — On a September Saturday evening, Dave Bennetts and his family sat around a campfire at Whitefish Lake State Park roasting marshmallows and eating smores.
Bennetts is the park manager, but Whitefish Lake State Park is also a favorite recreation destination for his whole family.
We live in town, so its convenient, Bennetts said of the park, located on west shore of Whitefish Lake, just outside of Whitefish.
Bennetts daughter Samantha, 4, likes to swim at the park, and his son Henry, 6, is a fan of fishing there.
As the Bennetts enjoyed their picnic on the warm September evening, they also enjoyed a stunning view of the Whitefish Lake and mountains in the background.
The lake was calm that evening, but the the 25-site campground was abuzz with campers.
The secrets out now that September is the best time in Montana, Bennetts said.
The mature forest in the Whitefish Lake State Park area gives the campsites a somewhat secluded feeling, with many sites being divided by tall trees.
Whitefish Lake State Park also offers a motorized boat launch and is a popular spot for water skiing and fishing.
Across the lake, sits Les Mason State Park. On the same September evening the day-use-only park was all but deserted just before sunset.
Les Mason offers 585 feet of sand and gravel lakeshore, as well as several picnic tables along the lakefront and a nonmotorized boat launch. Of the three public boat launches on Whitefish Lake, Les Mason is the only one thats nonmotorized.
The lakeshore is a short downhill walk from the parking area, which also gives the park a slightly more wild feel compared to the larger Whitefish Lake State Park.
Les Mason isnt quite as developed as Whitefish, Bennetts said. Its just a day-use park.
But if Henry had his choice, the family would have gone to Les Mason for their picnic.
Les Mason is more swim friendly, Bennetts said.
The park is pretty hopping on a warm summer day. It has a nice beach. Whitefish is very shallow, making it not-so-great for swimming.
Both parks offer designated swimming areas for dogs.
While Les Mason closes in the winter, while Whitefish Lake State Park is open year-round.
Les Mason will remain open until the snowfall limits vehicle access into the park, Bennetts said.
That means it could be open as late as the end of December depending on snow.
Once we close the gate, the park remains open throughout the winter to foot and ski access, he said.
Whitefish is a tourist town, so Whitefish Lake State Park is often full of visitors from across Montana, Alberta and elsewhere. Most summer nights, the campground fills up. But campers can make reservations in advance online through Montana State Parks Reserve Now program.
Whitefish Lake State Park is one of 20 state parks that allows for reservations. Campsites are reservable from the Friday before Memorial Day through Labor Day. Reservations can be made up to nine months in advance.
Whitefish Lake State Park gets a few campers throughout the winter, even though its flush toilets and shower facilities are shut down at the end of September and reopen in early May.
To get to Whitefish Lake State Park from downtown Whitefish, head west on West 2nd Street. Stay right onto Lion Mountain Road. Turn north onto State Park Road, which becomes West Lake Shore Drive.
To get to Les Mason State Park from downtown Whitefish, head north of Wisconsin Avenue. Follow it as it becomes East Lake Shore Drive. The park is on the west side of the road.
Reach Tribune staff writer Erin Madison at email@example.com. Follow her on Twitter @GFTrib_EMadison.


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New lawsuit filed against Pilot Flying J in federal fraud probe
KNOXVILLE — Pilot Flying J faces another federal lawsuit, this one filed by an Alabama trucking company, as a federal fraud probe continues.
The latest lawsuit, filed Friday by Montgomery, Ala.-based Eagle Motor Freight, seeks class-action status and names Pilot CEO Jimmy Haslam, Pilot President Mark Hazelwood, and sales executives John "Stick" Freeman and Brian Mosher personally as defendants. Haslam has denied any wrongdoing.
"The above-referenced wrongful acts violated all concepts of moral uprightness, fundamental honesty, fair play and right dealing in the general and business life of the members of society," attorneys for Eagle wrote in a complaint. "The above-referenced wrongful acts also were a consistent, regular and dominant part of the corporate culture and manner in which (Haslam and others) participated in and conducted the day-to-day business affairs of Pilot Flying J."
FBI and Internal Revenue Service agents raided Pilot's corporate headquarters in West Knoxville on April 15 to serve a series of search warrants as part of an investigation into trucking customers' complaints of being shortchanged on discounts and rebates for diesel fuel. Two Pilot employees, Ashley Judd and Arnold Ralenkotter, have pleaded guilty to federal fraud charges and agreed to testify against others.
Pilot faces three other federal lawsuits in Alabama, along with others in Tennessee, Ohio, Mississippi, Illinois and Arkansas. A Georgia company has sued in Knox County Circuit Court, with at least three other Pilot customers joining that lawsuit.
Map: Locations of companies that have filed lawsuits against Pilot Flying J
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Monday – Friday: 7 a.m. – 3 p.m. / Saturday & Sunday: 7 a.m. – 11 a.m.


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MRSA treatment 'may be more effective' if alternative drug used
The drug linezolid (Zyvox) may be more effective at treating patients with MRSA nosocomial pneumonia than the current gold standard vancomycin, according to trial results published in the journal Clinical Infectious Diseases.
Patients were randomized to receive intravenous linezolid (600 mg every 12 hours) or vancomycin (15 mg/kg every 12 hours) for up to two weeks.
Results showed 57.6% of 165 linezolid patients were cured, compared with 46.6% of 174 vancomycin patients.
However, there was no difference in mortality rates after 60 days and incidence of adverse events.
- Wunderink, RG et al. Linezolid in Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia: A Randomized, Controlled Study.
Clinical Infectious Diseases. First published online 12 January 2012.
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Erwin Chemerinsky
Antonin Scalia, Erwin Chemerinsky
With All Due Respect, Dean, Justice Scalia Probably Doesn't Give A Damn About What You Think
This law school dean thinks Justice Scalia is a bad influence on young attorneys.
Books, Erwin Chemerinsky, Quote of the Day, SCOTUS, Supreme Court
The Guy Who Wrote Your Con Law Book Thinks The Supreme Court Sucks At Its Job
Why did he have such a sudden change of heart?
Lean Legal: Three Techniques for the Agile Lawyer
A growing number of attorneys are turning to a set of project management and process improvement techniques commonly known as "Agile."
Cars, Erwin Chemerinsky, Hair, Law Schools, Non-Sequiturs, Police, SCOTUS, Supreme Court, Texas
* Dean Chemerinsky lays out how the Supreme Court is protecting local corruption. It's what the Framers would have intended. [New York Times]
* In response to the latest article from Professor Michael Krauss, a former student suggests that maybe the so-called "justice gap" is a good thing. It kind of comes down to how much you believe in the efficiency value of the "American Rule." [That's My Argument]
* The eternal question for female lawyers: do you dye your hair or embrace the gray? [Gray Hair]
* Boston's drivers suck. [The Faculty Lounge]
* A well-written tribute to a Nashville civil rights lawyer. [Nashville Scene]
* This seems like a place to remind people that David's going to Houston next month. [Above the Law]
* Here's a new game to check out. It's a twisted dirty word game called F**ktionary (affiliate link), so obviously it was made by a lawyer. It's kind of like Cards Against Humanity meets Scattergories, which is just as fun as it sounds. The promo is after the jump….
7th Circuit, Andrew Cuomo, Benchslaps, Biglaw, Blogging, Erwin Chemerinsky, Fast Food, Gay, Gay Marriage, In-House Counsel, Law Professors, Mergers and Acquisitions, Morning Docket, New York Times, Police, Politics, Richard Posner, SCOTUS, Sports, Supreme Court, Tim Wu
* Judge Posner dished out a whole lot of benchslaps at yesterday's Seventh Circuit arguments over Indiana and Wisconsin's bans on same-sex marriage. [BuzzFeed]
* Major U.S. and Canadian law firms chow down on Burger King's whopper of a deal with Tim Hortons. [Am Law Daily]
* A recent Delaware court ruling on attorney-client privilege might allow in-house lawyers to speak more freely about wrongdoing at their companies, according to Professor Steven Davidoff Solomon. [DealBook / New York Times]
* The corruption trial of former Virginia governor continues; yesterday Bob McDonnell's sister took the stand. [Washington Post]
* A favorable evidentiary ruling for Aaron Hernandez. [Fox Sports]
* And good news for Zephyr Teachout and Tim Wu, the two law professors running for governor and lieutenant governor of New York: the Times dissed their opponent, Andrew Cuomo, with a non-endorsement. [New York Times]
* I recently spoke with one of my cousins Joao Atienza of the Cebu Sun Star, about Above the Law and the world of legal blogging. [Cebu Sun Star]
Erwin Chemerinsky, Law School Deans, Law Schools
Law School Dean Thinks Law School Is Important
It's not that Dean Chemerinsky is wrong, it's just that a consistent blind spot clouds his argument…
Erwin Chemerinsky, Jeffrey Toobin, Politics, SCOTUS, Supreme Court
A Conservative Case For Keeping Cameras Out Of The Courtroom
Conservative columnist Tamara Tabo makes her case against cameras in the courtroom at SCOTUS.
Erwin Chemerinsky, Law School Deans, Old People, Quote of the Day, Ruth Bader Ginsburg, SCOTUS, Stephen Breyer, Supreme Court
Supreme Court Retirement Watch: Kindly GTFO, RBG
Con law king calls for Justice Ginsburg to resign ASAP.
Erwin Chemerinsky, Fast Food, Food, Gay Marriage, Law Professors, Law Reviews, Law Schools, Money, Non-Sequiturs, Rape
* When thinking of the Penn State situation (the alleged cover-up, not Jerry Sandusky's crimes), I am reminded of how critically important due process is to the proper administration of justice. You really notice due process when it's gone. [The Volokh Conspiracy]
* I haven't eaten at Chick-fil-A since college. Nohomo. [Fox News]
* It's funny to think of law professors getting their pieces rejected by law reviews. Funny insofar as there are people who actually care about what ends up in a law review. [lawprofblog]
* I'm not inclined to believe things coming out of Nigeria, but if this is true, it's crazy. [Gawker]
* The bright side of losing your job because of the LIBOR scandal. [Dealbreaker]
* Erwin Chemerinsky, Dean of the University of California Irvine School of Law, thinks that you can't cut faculty salaries enough to achieve substantial reductions in tuition without losing your top faculty. But in this market, I bet a law school that said, "We hire only cheap professors and pass the savings on to you," would have a lot of appeal. [National Law Journal]
Erwin Chemerinsky, Law Schools, Money, Student Loans
UC Irvine School of Law: Now Offering 33% Scholarships to the Class of 2014
When the UC Irvine School of Law first burst onto the scene, the school offered free tuition to everyone in its inaugural class. Then, in its second year, UC Irvine offered a 50% discount to all students admitted to the class of 2013. And now, UC Irvine will knock 33% off its tuition, for members […]
Inventors Will Lead the Legal Future not Licensees
David McCullough's The Wright Brothers serves as an ideal case study on the requirements to innovate; a desire to learn, perseverance, and work ethic. I read it in route to a wonderful opportunity to serve as visiting lecturer for Professor and Parsons Behle & Latimer attorney Randy Dryer's innovative Technology and Modern Litigation course at […]
Books, Erwin Chemerinsky, Non-Sequiturs, Stephen Wermiel
* Burberry sues Body Glove over an iPhone cover that makes your phone look like the inside of a Burberry trench coat. If Body Glove ever makes a condom packet that looks like the inside of a Burberry trench coat, married men will be interested in the proceedings. [Fashionista] * The new biography of Justice […]
Erwin Chemerinsky, Law School Deans, Law Schools, Politics, Vicious Infighting, Weirdness
Breaking: Erwin Chemerinsky to UC Irvine After All!
This email message, from Professor Erwin Chemerinsky to Duke law school faculty and students, went out ten minutes ago. Also, here's some coverage from the Los Angeles Times. ———- Forwarded message ———- From: "Erwin Chemerinsky" To: [redacted] Date: Mon, 17 Sep 2007 13:07:53 -0400 Subject: news It is with excitement and sadness that I am […]
Books, Carter Phillips, Celebrities, Dahlia Lithwick, Erwin Chemerinsky, Eyes of the Law, Jeffrey Rosen, John Yoo, Law Schools
The Eyes of the Law: Legal Celebrities Descend on William & Mary
Okay, so the folks over at TMZ.com don't chase them around yet. But here at ATL, we adore legal celebrities — and invite you to send in your encounters with them, for our Eyes of the Law sightings column. Last Friday, for lovers of legal boldface names from the left or the right, William & […]
Andrew Speaker, Blogging, Erwin Chemerinsky, Fashion, Intellectual Property, Non-Sequiturs
* Can a shoe infringe on copyright? [Fashionista] * Maybe there IS such a thing as bad publicity. Business ain't so hot for "TB Andy" right now. [WSJ Law Blog] * Some Chemerinskygate updates. [TaxProf Blog; TaxProf Blog] * Thinking of a career as a professional blogger? Read this first. [Career Journal]
Erwin Chemerinsky, Law School Deans, Law Schools, Politics, Vicious Infighting
Chemerinskygate: Dean for a Day?
Who knew that such a little man could generate such big controversy? In a nutshell (see the links collected below for more): Erwin Chemerinsky, the brilliant but controversial professor of constitutional law at Duke, accepted an offer to serve as inaugural dean of UC Irvine's new law school. But then Professor Chemerinsky's deanship was yanked […]
David Boies, Education / Schools, Erwin Chemerinsky, Fabulosity, Federal Judges, Laurence Tribe, Law Professors, Merrick Garland, Peter Barta, Samuel Alito, Supreme Court Clerks, Thomas Goldstein
Our Apologies to All Former Policy Debaters (Except the Creepy Ones)
In a recent post about Peter Barta, the Legal Aid lawyer who allegedly videotaped his female colleagues as they were getting undressed, we ranked on policy debaters. Maybe we should take it back. From a highly informative reader email: Not all former policy debaters are creeps. Here's a list of former policy debaters who are […]
2nd Circuit, Erwin Chemerinsky, Gender, Goldman Sachs, Hotties, Money, Wall Street, WSJ Law Blog
Shouldn't That Be "Mistress" of the Universe?
Our big sibling reports on the departure of high-finance hottie Suzanne Nora Johnson from Goldman Sachs, the obscenely profitable investment bank. Johnson, who served on the firm's 23-member management committee, was the highest-ranking woman at Goldman Sachs.* And as the WSJ Law Blog notes, in a post entitled Associates, You Too Can Become a Master […]


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Recovery Continues Two Weeks After Superstorm Sandy
Palabras clave
People receive free food from the American Red Cross in the heavily... Fotografía de noticiasAccidentes y desastres,Agua,Alimento,Caridad y Auxilio,Ciudad de Nueva York,Corte transversal,Cruz Roja estadounidense,Dañado,EE.UU.,Encuadre cintura para arriba,Horizontal,Libertad,Paso Entablado,Personas,Queens,Recibir,Rockaway Peninsula,Tormenta,Viento,Zona residencialPhotographer Spencer PlattCollection: Getty Images News 2012 Getty ImagesNEW YORK, NY - NOVEMBER 14: People receive free food from the American Red Cross in the heavily damaged Rockaway neighborhood where a large section of the iconic boardwalk was washed away on November 14, 2012 in the Queens borough of New York City. Two weeks after Superstorm Sandy slammed into parts of New York and New Jersey, thousands are still without power and heat. (Photo by Spencer Platt/Getty Images)


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|Letters From Secret Santa
Take a holiday trip through various locales and discover different Christmas traditions as you journey inside the imagination of a small boy reading letters from his secret Santa, in this text platformer unlike any other you've ever played.
|Laundry Day
It's time to do your laundry! Remember to clean out the dryer's lint screen, and don't forget to IM to your friends about your wonderful adventure in the laundromat!
|Suddenly, Thousands
Suddenly, Thousands is a mob controlling game that takes inspiration from Pikmin and The Swapper.
|Make it Juicy: Easy Methods to Make Your Game More Engaging
Make it Juicy: Easy Methods to Make Your Game More Engaging is a presentation I made that lists various techniques I use to make my games more fun to play.
|Not a Clone
Not a Clone is a satire on the rampant clones that appears in the mobile game market.
|Ichabot Crane
A first-person puzzle game like Portal where you have to use your head…by throwing it.
Guide Top Hat Joe as he ventures on his heroic journey to achieve heights he has never reached before.
|Galactic NEON
A colorful twin-stick shooter, like Geometry Wars, in the vast infinite space similar to Asteroids.
|String Theory
A bizarre physics game where you have a fishing pole whose lure can attach to larger and large objects.
|The Sentient Cube
A Ludum Dare 26 entry: play as a sentient cube that can stick to other smaller objects to grow larger.
|Touch Yoga
A simple multi-touch game where one must touch and hold all circles on the screen for four seconds.
|The Heart of Darkness
A lone construction worker gets stuck in a dark and abandoned space station. He must rely on the commands given by his partner robot to navigate the treacherous place.
A pacifist action game that involves defeating a swarm of enemies through deception.
|ABCs Learn & Sing
An easy way to teach pre-schoolers their ABCs.
|Solitaire Double-Deck HD
A popular card game for iPad and Android tablets.
|Susie's Summer Home
An experimental horror game, where one navigates Susie's maze-like summer home.
A game of destruction with unique controls.
|Save The Princess
A surreal 3D-slasher that parodies Japanese pop-art.
A first-person puzzler involving a gravity gun.
|Trip Trap
An evasive game that involves tricking bees.
|Project ErisA recreation of the board game Blokus.
A simple tank game that uses only one button.
A platform-puzzler that involves in gravity-reversing solutions.
|Protect Your Base
A Warlords clone using OpenGL and GLUT.


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When Silence Screams
This much-needed voice provides a raw, real look at life with bipolar disorder. When Silence Screams: Living With Bipolar Disorder; Journals 1997–2011, by Katherine L. Fogg,... Read More
This much-needed voice provides a raw, real look at life with bipolar disorder. When Silence Screams: Living With Bipolar Disorder; Journals 1997–2011, by Katherine L. Fogg,... Read More
This compelling memoir provides a friendly comfort, especially for those with a loved one who is slowly dying. Not Really Gone, by Blaire Sharpe, is a memoir about a... Read More
Mark gives an invitation to flee modernity and embrace mysterious nature as he shares the poetic insights he found in the wild. Satellites in the High Country: Searching for the... Read More
A daughter's heartfelt recollection of her last days with her mom, with a poignant introduction by Mitch Albom. Lisa Goich was there to witness all of her mother Millie's... Read More
This emotionally moving tribute gives insight into how Jackie Robinson affected the racial climate of Brooklyn and the nation. Breaking Ground: How Jackie Robinson Changed... Read More
Adam's linchpin role in debates on original sin provides Christians with an ideal framework in which to explore matters of science and truth. Saving the Original Sinner: How... Read More
A soothing, healing work for teens and adults whose lives bear the mark of their parents' immaturity. Adult Children of Emotionally Immature Parents: How to Heal from Distant,... Read More
Missing Frames offers compelling insights for survivors of traumatic brain injury and their friends and family. Missing Frames: Memoir of a Woman Living with Hidden... Read More
Borrowed Bibles draws from a past era, and a specific life, yet speaks to the broader issues of America today. Borrowed Bibles: A Memoir, by Jim Good, is a story of faith and... Read More
India: Future Tense is a must-read for anyone curious about India's evolving role on the world stage. India: Future Tense, by Peter Richards, is a clear, compelling look at... Read More
This novel's theme is encouraging, inviting, and compelling: God calls ordinary people to fulfill his purpose in ways they could never imagine. Walking with Herb: A Spiritual... Read More
The Painful Truth is an invaluable, hope-filled resource for individuals—and societies—consumed by pain. The Painful Truth: What Chronic Pain Is Really Like and Why It... Read More


text:
- Filed Under
A judge on Wednesday denied bond to a Stuarts Draft man implicated in last month's shooting death of a Staunton man.
Steven G. Moore, 61, is charged with first-degree murder in the March 14 slaying of 51-year-old Van W. Bell Jr.
Bell was killed in the front yard of his home at 821 Fisher Circle. Staunton police said he was shot more than one time. ...


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Broncos quarterback Peyton Manning is in his 16th NFL season. Manning is 37 years of age, but he has not shown any signs of slowing down. This season, he broke the single-season record for passing touchdowns.
After practice on Wednesday, Manning said he is enjoying every day at work.
"It'll be a great atmosphere Sunday playing a good football team, and there's nothing else I'd rather be doing than to be in that opportunity," Manning said. "It's certainly my goal to enjoy the preparation, not just the game, to actually enjoy the preparation part of it, enjoy being around the guys. Because certainly the light is at end of tunnel for me, no question, so you enjoy these things maybe even more than maybe you have in the past."


text:
We have booked an appartment at Haus Wesnau through Booking.com and were given a confirmed price for our stay. Prior to our arrival we have corresponded with the owner who confirmed our reservation and price. We have paid the requested downpaiment which also included a transfer fee. However, much to our astonishment once we were at their residence, the owner... More
If you own or manage Haus Wesenau, register now for free tools to enhance your listing, attract new reviews, and respond to reviewers.


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Use good preserved cherries in an easy, flavorful recipe. Serve warm or cold with cream or ice cream.
- For the Cake:
- 3/4 cup plus 1 tablespoon butter
- 1 cup sugar
- 2 eggs
- 2 1/4 cups all-purpose flour, sifted
- 2 teaspoons baking powder
- 1 cup bottled or canned red cherries, pitted and drained
- 1 teaspoon ground allspice
- For the Streusel Topping:
- 1/4 cup butter, chopped
- 1/2 cup all-purpose flour
- 1/4 cup superfine sugar
- 1/3 cup sliced almonds
- 1/2 teaspoon ground allspice
- Heavy cream or ice cream, for serving
Preheat the oven to 350 degrees F.
Lightly grease an 8-inch springform cake pan and line the base with parchment paper.
Cream the butter and sugar in a bowl until light and fluffy. Add the eggs, one at a time, beating well. Fold in the flour and baking powder and mix well.
Spread half of the cake batter evenly onto the base of the prepared pan. Top with the cherries, then sprinkle with the allspice. Spread the remaining cake batter over the cherries.
Rub the butter into the flour until the flour mixture resembles breadcrumbs. Mix in the sugar and almonds until well combined.
Press the streusel topping on top of the cake. Sprinkle with the allspice. Bake for 45 minutes, or until a skewer inserted in the middle of the cake comes out clean. Let the cake rest in the pan for 10 minutes before turning out onto a wire rack to cool completely.
Serve warm or cold with cream or ice cream.
Recipe reprinted by permission of Weldon Russell. All rights reserved.
RecID 1094
nutrition information per serving
375 calories; 19g total fat; 79mg cholesterol; 53mg sodium; 47g carbohydrates; 1g fiber; 5g protein
These nutrition facts are calculated according to the ingredients listed in this recipe. Any substitutions will change these facts. Although we strive for accuracy, please note that food manufacturers occasionally change their food formulas, which could affect the calculations as shown.
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text:
Our Growing Gun Culture
Australians imported more than 730,000 firearms in the 16 years since the mass shooting at Port Arthur - that's more than were destroyed in the buy-backs since 1996 - and last financial year we imported more guns into Australia than ever before.
So who is this new generation of legal firearm owners, and why is their political influence growing?
From sporting shooters to farmers controlling pests - Hack takes a look at our growing legal gun culture.
Listen to our special report below
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text:
To see the interactions in real time, Suo and colleagues were the first to insert fluorescent markers into each of the four components of the enzyme called the palm, thumb, finger and little finger. They also placed markers in a strand of DNA. Previous studies have emphasized just one enzyme domain at a time.
The polymerase interacts with DNA to start the copying process in the presence of a nucleotide in this case, a molecule called dNTP. The scientists used fluorescence resonance energy transfer technology to see the action take place.
They described the process as a series of eight critical steps that proceed with three distinct movements in the presence of a dNTP. The enzyme stands alone until it binds to DNA. The enzyme and DNA undergo repositioning when the nucleotide binds to the polymerase, and the enzyme's domains begin to move, gripping the template DNA strand. The DNA strand must move from what is known as the pocket to allow binding and incorporation of the nucleotide in the correct place.
By step five in the process, the DNA copy has been extended, and in the following steps the enzyme begins its relaxation motions allowing the DNA to shift to allow for placement of the next nucleotide.
Those who study DNA polymerases seek to define what is called a rate-limiting event, which could be thought of as a moment when all parts of the process pause and check themselves over. Because errors occur in the DNA copying process, the rate-limiting step must be known to completely understand the copying mechanism, Suo noted.
To date, scientists have believed that the rate-limiting step in this process occurred long before the placement of the nucleotide. To check t
|Contact: Zucai Suo
Ohio State University


text:
|Publication number
|Publication type
|Application number
|Publication date
|24 Apr 2003
|Filing date
|21 Nov 2002
|Priority date
|5 Aug 1999
|Also published as
|Publication number
|Franco Vallana, Maria Curcio, Giovanni Rolando
|Original Assignee
|Franco Vallana, Maria Curcio, Giovanni Rolando
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (5), Referenced by (39), Classifications (20)
|External Links: USPTO, USPTO Assignment, Espacenet
[0001] This application is a divisional application of U.S. Ser. No. 09/632,042, filed Aug. 3, 2000, hereby incorporated herein by reference. This application claims benefit to foreign application TO99A000693 filed in Italy on Aug. 5, 1999.
[0002] The present invention relates to angioplasty stents. In particular, this invention relates to a stent structure that minimizes restenosis.
[0003] The term "stent" is used to indicate in a general way those devices intended for intravascular application (for example inside a blood vessel), usually carried out by catheterization followed by in-situ expansion in order to exert an action of local support to the lumen.
[0004] For a general overview of vascular stents the reader may usefully refer to the work "Textbook of Interventional Cardiology", ed. Eric J. Topol, W. B. Saunders Company, 1994, and in particular section IV of vol. II entitled "Coronary Stenting".
[0005] The subject has also attracted a large number of patent documents, as witness, for example, EP-A-0 806 190, EP-A-0 850 604, EP-A-0 847 766, EP-A-0 857 470, EP-A-0 875 215, EP-A-0 895 759, EP-A-0 895 760.
[0006] The clinical use of these devices, which in recent years has grown considerably in popularity, must address the need to ensure an effective impediment to the phenomenon usually known as restenosis. This is a phenomenon (linked to the manifestation of physiological mechanisms that, furthermore, are not yet clearly understood) whereby the stenosis site, after having been reopened by the implant of the stent, gradually tends to close up again, usually owing to gradual tissue growth.
[0007] Various solutions have been proposed for dealing with this problem: they essentially involve a local action designed to impede the phenomena that give rise to the restenosis. In particular, a number of solutions have been investigated in which drugs are released locally or radioactive sources are used locally.
[0008] These solutions, especially those based on the localized and controlled release of drugs, have themselves to address the problem of how this localization is to be effectively carried out at the stent implant site. In the case of agents designed to be released by the stent, it is important to ensure that the majority of the agents are released gradually into the walls of the vessel rather than being washed away relatively rapidly by the flow of blood passing through the lumen of the stent. This is particularly important because clinical experiments show that the mechanisms of reaction of the vessel subjected to the stent implant occur at the level of a reaction by the vessel wall within a period of time typically ranging from 1 to 6 months from implantation.
[0009] It is an object of the present invention to provide a solution capable of improving on previously attempted solutions, from a number of points of view. First, it is wished to be able to achieve a reliable connection, or anchoring, of therapeutic agents to the stent, and in particular a connection that will not be influenced either by the movement of the stent as it dilates, which is characteristic of the implanting operation, or by possible surface treatments (such as deposition of a surface layer of biocompatible carbon-containing material) which may have been applied to the stent.
[0010] Second, it is wished to be able to produce a collection of components capable of acting in effect as a "releasing machine" that will deliver a controlled release of restenosis-impeding agents, particularly as regards the possibility of precisely controlling the release kinetics, with the further possibility of selectively controlling, in time or in relation to other parameters, the release of diverse agents.
[0011] Again, it is wished that the functions specified above be able to be carried out without negative impacts on the other characteristic aspects of the functionality of the stent, e.g., by ensuring that, whether at the time of implantation or later, the lumen of the stent does not become a site for obstructions to the free flow of blood.
[0012] In one aspect, this invention is stent structure having a longitudinal axis and having a substantially tubular body capable of being dilated from a radially-contracted position to a radially-expanded position comprising a stent having an inner surface and an outer surface; and at least one fiber disposed adjacent one of the surfaces of the stent, the fiber adapted to provide a therapeutic agent. Preferably, the therapeutic agent is an agent that impedes restenosis. The fibers preferably are attached to the stent structure such that the fibers do not substantially retard dilation of the stent structure from the radially contracted position to the radially expanded position. The therapeutic agent may be contained within a nucleus embedded in the at least one fiber or may be within a lumen defined by the at least one fiber. The therapeutic agent may be in a nucleus where the nucleus is in a particle contained within an outer envelope. Preferably, the outer envelope is bioerodible. The particle may range in size from 100 to 200 nanometers. Preferably, the fiber is bioerodible.
[0013] The stent structure may also comprise a sheath interposed between the stent and the fiber. The sheath may be a biocompatible material, such as silicone, and may be permeable. Alternatively, the sheath may comprise a metallic material or a polymeric material and have an apertured structure, such as a mesh, so that it may expand when the stent structure expands. The sheath may be coated with a layer of a biocompatible carbon-containing material. The fiber may be anchored to the sheath. There may be multiple fibers disposed around the stent. The fiber preferably is extensible in the direction of the longitudinal axis. The fiber may be wound around the stent structure in a helical path with a winding pitch of 45� or 60� relative to the longitudinal axis. The fiber may comprise a porous structure. The fiber diameter can range between about 30 and 100 micrometers and have wall thickness ranging between about 10 and 20 micrometers. The therapeutic agent may comprise one or more drugs selected from anti-inflammatory and antimitotic agents.
[0014] In a second embodiment, this invention is a kit for impeding restenosis in vasculature comprising a stent that can be dilated from a radially contracted position to a radially expanded position; at least one fiber comprising a restenosis-impeding agent; a catheter adapted to deliver the stent and the at least one fiber to a site of restenosis; and a container configured to house the stent, the at least one fiber, and the catheter. The fiber may comprise a sheet configured to be wound around the stent or a tubular sock configured to be fitted onto the stent.
[0015] In a third aspect, this invention is a component for delivering a therapeutic agent that impedes restenosis, the component for use in combination with a stent having a longitudinal axis and having an inner surface and an outer surface, the component comprising at least one fiber configured to be placed adjacent a surface of the stent; a particle contained by the at least one fiber, and a nucleus contained within the particle, the nucleus adapted to contain the therapeutic agent. The particle may be contained within a lumen defined by the at least one fiber and/or may comprise the nucleus contained within an outer envelope. The therapeutic agent that impedes restenosis may further comprise one or more drugs selected from anti-inflammatory and antimitotic agents.
[0016] In a fourth aspect, this invention is a method of impeding restenosis in a patient's vasculature comprising: providing a stent having an inner surface and an outer surface and a longitudinal axis and being capable of being dilated from a radially-contracted position to a radially-expanded position; providing at least one fiber adapted to deliver a restenosis impeding agent; providing a delivery catheter; mounting the stent and the at least one fiber onto the delivery catheter; and advancing the delivery catheter to the patient's vasculature to deliver the stent and the at least one fiber at the site of stenosis.
[0017] The invention will now be described, purely by way of non-restrictive example, with reference to the accompanying drawings, in which:
[0018]FIG. 1 is a perspective view, with some parts removed for clarity of illustration, of the preferred angioplasty stent structure of the invention.
[0019]FIG. 2 is an enlarged cross-sectional view along line II-II of the stent structure of FIG. 1.
[0020] FIGS. 3 to 5 are cross-sectional views of the particles illustrated in FIG. 2.
[0021]FIGS. 6 and 7 illustrate perspective views of fibers used in a preferred embodiment of the stent structure of FIG. 1.
[0022] In FIG. 1, reference number 1 indicates a preferred embodiment of the angioplasty stent structure of the invention. For a general identification of the modes of use and production features of such an implant device, refer to the documentation cited in the introductory part of this description.
[0023] By way of an overview, it will be recalled that stent structure 1 is usually produced as a generally tubular body, with a total length usually varying from a few millimeters to tens of millimeters and a wall thickness (the wall usually having an open structure of links or loops) of the order of, for example, a few hundredths of a millimeter (mm). These features are all with a view to the possible insertion of the stent into a lumen (such as a blood vessel), in a site suffering from stenosis which is to be corrected. The stent is moved into position, e.g., by catheterization, and than expanded radially from its diameter of insertion, which is of the order of about 1 mm, to an expanded diameter of the order of about 3 to 5 mm. In the expanded condition the stent supports the lumen and eliminates the stenosis. The outside diameter when radially contracted is selected so as to allow the stent to be inserted into the lumen where the treatment is being carried out, while the expanded diameter corresponds generally to the desired diameter that establishes and maintains the lumen once the stenosis has been eliminated.
[0024] Although the principal application of the stent described above refers to the treatment of blood vessels, it is possible (and therefore included within the scope of the invention) to fit it as a support for any lumen present in the human or animal body.
[0025] As far as the methods and principles that enable the stent to be opened (i.e., expanded in situ) are concerned, the solution that is most widely used at present is to employ what is known as a balloon catheter. The stent is mounted around the balloon of the catheter in its contracted condition and the balloon is expanded once the stent has been delivered to the site of the implant (see, for example, FIG. 1, where the outline of the catheter balloon, labeled C, has been indicated schematically in broken lines). However, other methods may also be envisaged, such as that of employing superelastic materials which expand the stent once the containment components, designed to keep the stent contracted until it reaches the site of the implant, have been removed. Additionally or alternatively it has also been suggested that the stent be made from materials having a so-called "shape memory" enabling it to be expanded radially in the implant position.
[0026] Usually, as is known in the art, the stent is made from a metallic material that reconciles two fundamental requirements for application, that is an ability to deform plastically during the expansion and an ability to maintain its expanded form by resisting stresses that would tend to re-close the stent.
[0027] These technological issues will not be discussed in detail in the present description inasmuch as they are not in themselves relevant to an understanding of the embodiment of the invention. This is essentially true also for the technology of manufacture of the stent (manufacture from a continuous tubular preform, manufacture from a striplike body which is then closed into a tube, manufacture from a shaped metal wire, etc.).
[0028]FIGS. 1 and 2 illustrate stent structure 1, comprising stent 2, sheath 5, and one or more fibers 4 disposed around sheath 5. Stent structure 1 is delivered to the vasculature by means of catheter C, as described above. Stent structure 1 is a generally tubular body capable of being selectively expanded radially by the principles described above. In other words the solution according to the present invention is in fact quite "transparent" or at any rate not appreciably influenced by the specific characteristics of geometry, treatment and technology of manufacture of stent 2.
[0029] Fiber 4 is adapted to deliver a therapeutic agent such as a restenosis impeding agent. Fiber 4 may have restenosis impeding agents embedded in it or inside of it. Fiber 4 may have hollow core 40 surrounded by wall 42. Core 40 can be filled with particles comprising a desirable restenosis preventing agent. Alternatively, therapeutic agents may be disposed within the fiber wall. Before turning to a more detailed explanation of the characteristics of stent structure 1, it is useful to refer to FIGS. 3 to 7, which show a number of the components used to make the stent structure of this invention.
[0030] Specifically, FIGS. 3 to 5 illustrate, in a number of possible variants, particles 3, 3′ and 3″, respectively. Preferably these particles are spherical or substantially spherical in shape and have typical diameters of the order of hundreds of nanometers. Particles of this size are referred to as "nanoparticles". FIG. 3 illustrates particles 3 comprising nucleus 3 a surrounded by outer envelope 3 b. FIG. 4 illustrates nucleus 3 a′ that is similar in size to nucleus 3 a of FIG. 3, except that outer envelope 3 b′ is smaller than 3 b, resulting in a smaller particle that can deliver the same amount of therapeutic agent. FIG. 5 shows that nucleus 3 a″ and/or envelope 3 b″ may have a complex structure (i.e., 3 a″ having two or more nuclei and/or 3 b″ having a stratified, or multi-layer, outer envelope). Further, particles having multiple nuclei may be able to deliver more than one therapeutic formulation. It is also possible for the nuclei 3 a, 3 a′, or 3 a″ not to be in the approximate center but instead be eccentric relative to the envelope 3 b, 3 b′, or 3 b″, respectively. The rest of this description will however refer for simplicity's sake to nucleus 3 a and to envelope 3 b of substantially uniform, homogeneous structure and substantially concentric with each other.
[0031] Nucleus 3 a includes a therapeutic agent capable of exerting an antagonism towards restenosis by the effect of an action of localized release and/or selective penetration into the walls of the vessel where the stent is implanted. Nucleus 3 a also may comprise, for example, a drug or collection of drugs whose action is anti-inflammatory, antimitotic and/or promotes the processes of repair of the vessel wall such as to mitigate or prevent the reactions on which the process of restenosis is based. However, the particular choice of agent and/or collections of agents is not specifically the subject-matter of the present invention.
[0032] The above remarks also apply to the manufacture of the envelope 3 b. Outer envelope 3 b of particle 3 comprises any substance that can be described as "bioerodible". This expression is intended here to denote any substance which, within the context of the present invention (namely implantation in a lumen), tends to be consumed and/or to adopt or demonstrate a porous morphology or any morphology such as to allow the outward diffusion of the substance or substances contained inside nucleus 3 a. The properties of bioerodibility described are typically accompanied by properties of biocompatibility and biodegradability which are important in this specific application.
[0033] One choice for the production of envelope 3 b is polyethylene glycol (PEG) or polylactic-glycolic acid (PLGA) as the constituent material. The method of production of these is known in the art.
[0034] The corresponding release kinetics can be controlled (especially as regards the time required to achieve outward diffusion of the agents contained inside the nucleus 3 a) by varying, individually or in combination, the following parameters:
[0035] the composition of the nucleus 3 a,
[0036] the composition of the envelope 3 b,
[0037] the thickness of the envelope 3 b,
[0038] the relative location of the nucleus 3 a with respect to the envelope 3 b,
[0039] the structure (homogeneous, multiple and/or stratified) of the nucleus 3 a, and
[0040] the structure (homogeneous, multiple, stratified and/or porous) of the envelope 3 b.
[0041]FIGS. 3 and 4 illustrate, purely by way of example, the option of producing two particles 3 containing nuclei 3 a with dimensions roughly equal to each other in combination with envelopes 3 b of differing thicknesses. In all cases the principles, methods and technologies relating to the production of nanoparticles such as the nanoparticles 3 shown in FIGS. 3 to 5 should be taken to be well known in the art.
[0042] The above remarks also apply in substance to the option of having nanoparticles 3, 3′, and 3″, such as those shown in FIGS. 3 to 5, respectively, to (whether identical to each other or not) accompany fibers 4 that are also preferably made from bioerodible materials such as the materials cited earlier.
[0043] The production of fibers 4 and their provision with nanoparticles 3 correspond to known solutions. In particular, the production of microfibers in the form of hollow-fiber membranes is well known and well established at the technological level in the manufacture of devices such as dialyzers or oxygenators of the blood.
[0044]FIG. 6 illustrates fiber 4 having hollow core 40 and wall 42. Hollow core 40 is filled with nanoparticles 3. Alternatively, or additionally, as shown in FIG. 7, wall 42 of hollow core fiber 4 may contain nuclei 4 a. The fiber thus acts as an erodible support. Nuclei 4 a may be the same composition as described above for nuclei 3 a and thus provide an additional means to convey restenosis-impeding agents when stent structure 1 is implanted. It is also contemplated to use, at least locally in the environment of stent structure 1, fibers 4 that do not allow for the placing of nanoparticles 3 in lumen or core 40 of fibers 4. In this case, the fact that fibers 4 have hollow-fiber characteristics is not critical, and the use of fibers 4 of compact structure, having no hollow core, is therefore also possible. By analogy, with reference to the diagram of FIG. 6, it is possible to use porous hollow core fibers 4 of a non-bioerodible material that would act exclusively as containers for nanoparticles 3. Porous fibers would allow the diffusion of the agents carried by nuclei 3 a of nanoparticles 3.
[0045] To give some idea of dimensions, fiber 4 (as shown in the drawings) may have diameters ranging between about 30 and 100 micrometers, with wall thicknesses typically ranging between about 10 and 20 micrometers, and therefore with corresponding dimensions of its lumen or axial cavity ranging between about 10 and 60 micrometers. A sufficient length of fiber is chosen such that a desired amount of the restenosis-impeding agent is delivered.
[0046]FIGS. 1 and 2 illustrate that fibers 4 may attach to stent 2 of stent structure 1 in one or more layers. The fibers optionally may be interlinked with stent 2 by using the open configuration of stent 2. In a preferred embodiment, fibers 4 are wound around stent 2. The winding arrangement (or more generally the placement) of fibers 4 on stent 2 must of course take account of the fact that fibers 4 are normally laid on stent structure 1 when the latter is in its radially contracted position and must not therefore be damaged or altered in their functionality by the radial expansion which typifies the operation of implanting the stent structure. That is, fibers 4 are attached to stent 2 in such a way as to present virtually no resistance to the dilation characteristic of the stent.
[0047] This result can be achieved in several different ways. In the example of an embodiment illustrated here, fibers 4 have been wound around the structure of the stent by known processes and devices (as described in, for example, U.S. Pat. No. 4,952,312 (Zantonelli et al.)) hereby incorporated herein by reference, in such a way that the angle formed by the fibers relative to the family of planes perpendicular to the longitudinal axis of the stent (in practice the angle of winding of the helical path defined by each fiber) is relatively great, preferably at least 45� and still more preferably greater than 60�. Alternative solutions are of course possible, such as for example that of making fibers 4 from elastic materials and/or that of causing fibers 4 to follow a sinuous path; the purpose being to ensure the fibers can stretch in the longitudinal direction.
[0048] For the purpose of laying fibers 4 on stent 2 it is also possible to exploit the presence (initially dictated by other reasons explained below) of sheath or tunic 5 interposed between structure 2 and the layer or layers of fibers 4 laid around it. Specifically, it is possible to consider applying fibers 4 to stent 2 of stent structure 1 by connecting them (e.g., by an adhesive connection) to the outer surface of sheath 5. In this embodiment it is possible to locate fibers 4 (whether ordered in a single layer or whether present in two or more layers) so that fibers 4 run generally along the generatrices of the imaginary cylindrical surface defined by stent structure 1. A solution of this kind would ensure that the movement of radial dilation of stent 2 has no effect on fibers 4.
[0049] The main purpose of sheath 5 is to prevent the undesirable prolapse of fibers 4 into the lumen of the stent structure 1. Prolapse can occur, for example, if stent 2—whether in its entirety or even only partly—has a highly apertured configuration. Accordingly, sheath 5 has the function of ensuring that, even following implantation, fibers 4 preferably stay outside stent 2 and are interposed between the stent structure 1 and the vessel wall.
[0050] The presence of sheath 5 is also beneficial at later stages, namely when the agents present in nuclei 3 a and 4 a are diffused. This is because sheath 5 is able to act at least partly as a barrier and so ensure that the release of the above-mentioned active agents takes place preferably and primarily towards the wall of the vessel and not towards the interior lumen of stent 2, which would mean that blood flowing through the lumen would wash the active agents away.
[0051] For the manufacture of sheath 5, it is possible to employ various materials, preferably with good biocompatibility properties, whether owing to the nature of the constituent material or to the fact that sheath 5 has been subjected to a treatment such as surface deposition of a layer of biocompatible carbon-containing material. An option that is thought preferable is to make sheath 5 from a silicone material. Alternative options are of course possible, such as making sheath 5 in the form of a tunic of a metallic or polymeric net having an apertured structure, such as a fine mesh capable of reproducing the movement of the stent as it expands.
[0052] The option of making sheath 5 with general characteristics of porosity (or more generally of permeability, which may be more effective on substances moving out through the stent structure than on substances moving in the opposite direction) is advantageous because it promotes contact between the vessel wall and the blood flowing through the stent, while at the same time preventing the flushing away of the active agents.
[0053] Fibers 4 can be laid on the structure 2 at different stages of the process of manufacture and/or preparation for the use of the stent 1. In particular (irrespective of the principles whereby fibers 4 are applied to stent 2) fibers 4 can be applied in the final stages of manufacture of the stent structure and thus before the stent structure is mounted on catheter C used for its delivery to the site. Alternatively, the fibers can be applied after stent 2 (and, optionally, sheath 5) has been mounted on the implanting catheter.
[0054] The collection of fibers 4 can therefore constitute a component of a kit which, in a form currently preferred for marketing, constitutes the product made available for the purposes of the implanting operation. The kit comprises a stent, the fiber(s), and a delivery or implanting catheter in a container adapted to hold the various components. Suitable containers include flexible pouches and rigid containers, such as plastic containers.
[0055] As another alternative it is possible to attach the fibers to the stent structure at an even later stage, that is immediately before proceeding to implant the stent (before or after the stent has been positioned on the implanting catheter). For this reason the fibers 4 may constitute an independent product or component capable of being marketed, e.g., in different versions included in an assortment and characterized by the presence of different kinds of agent and/or different kinetics of release. In particular this product may take the form of, for example, a small sheet (e.g., a piece of fabric that may be woven, non-woven, knitted, or the like) designed to be wound around the stent or may take the form of a tubular sock for fitting onto the stent.
[0056] It is clear from the above that this invention provides a "releasing machine" for the controlled release of restenosis-impeding agents. In particular, the dimensions of nanoparticles 3 and of nuclei 3 a or 4 a are such that even within the limits of a structure of small dimensions such as a stent it is possible to have a very large number of nuclei. Consequently the natures and properties of the impeding agents are available over a wide range of choices. As to the release kinetics, it is important to note that this invention makes it possible to act both at the level of nanoparticles 3 and at the level of fibers 4, for example by altering the composition, thickness or structure (making it homogeneous, stratified and/or porous) of the fibers 4, as well as on the location of the nuclei within the fibers (locating them directly, as in the case of the nuclei 4 a, or indirectly by incorporating them in nanoparticles 3 which in turn are incorporated in the wall of a fiber). There is also the option of modifying the further parameter represented by the optional porosity of sheath 5.
[0057] Of particular interest is the possibility of operating in a combined way on the above-mentioned parameters, by, for example, causing the agents contained in nuclei 3 a or 4 a to diffuse over different time periods to those of the agents contained in other nuclei 3 a or 4 a in order that the restenosis-impeding action exactly keeps pace with the manifestation of the phenomena that give rise to restenosis itself. As an example, it may be decided that the release of anti-inflammatory drugs and/or promoters of vessel-wall repair processes should predominate in the acute phases, while antimitotic agents should be released predominantly at a later stage.
[0058] Various modifications and alterations to this invention will become apparent to those skilled in the art without departing from the scope and spirit of this invention. It should be understood that this invention is not intended to be unduly limited by the illustrative embodiments and examples set forth herein and that such examples and embodiments are presented by way of example only with the scope of the invention intended to be limited only by the claims set forth herein.
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|Ethicon Endo-Surgery, Inc.
|Multi-axis articulating and rotating surgical tools
|26 Feb 2013
|22 Sep 2015
|Ethicon Endo-Surgery, Inc.
|Surgical stapling instrument with an articulatable end effector
|29 Oct 2003
|5 May 2005
|Pomeranz Mark L.
|Expandable stent having removable slat members
|1 Aug 2006
|30 Nov 2006
|Yip Philip S
|Drug-eluting stent cover and method of use
|25 Aug 2006
|21 Dec 2006
|Advanced Cardiovascular Systems, Inc.
|Drug-eluting stent and methods of making the same
|1 Aug 2006
|29 Mar 2007
|Yip Philip S
|Drug-eluting stent cover and method of use
|28 Mar 2012
|27 Sep 2012
|Ethicon Endo-Surgery, Inc.
|Tissue thickness compensator comprising structure to produce a resilient load
|2 Jul 2012
|17 Jan 2013
|Boston Scientific Scimed, Inc.
|Drug elution medical device
|15 Nov 2007
|19 Jun 2008
|Mallinckrodt Inc
|Medical devices for localized drug delivery
|U.S. Classification
|623/1.11, 623/1.43, 623/1.13
|International Classification
|Cooperative Classification
|European Classification


text:
Temple Run 2
By Imangi Studios, LLC
Open iTunes to buy and download apps.
The sequel to the smash hit phenomenon that took the world by storm!
Temple Run redefined mobile gaming. Now get more of the exhilarating running, jumping, turning and sliding you love in Temple Run 2!
Navigate perilous cliffs, zip lines, mines and forests as you try to escape with the cursed idol. How far can you run?!
* Beautiful new graphics
* Gorgeous new organic environments
* New obstacles
* More powerups
* More achievements
* Special powers for each character
* Bigger monkey!!!
Become a fan of Temple Run on Facebook:
Follow Temple Run on Twitter:
What's New in Version 1.17
- Celebrate Usain Bolt's race for history at the World Championships by downloading his new outfit!
- Bug Fixes and Optimizations
Customer Reviews
Game that never ends
What can I say it's a game that never ends I mean like IT HAS NO ENDING and that is what makes it so addicting so I recommend this game to anyone and everyone so get the game ladies and gents because you will enjoy it just like me I don't even know how to end this comment this game is so good I mean omg this is sooooooo good get this game omg get this game u will tots take my offer for it ok noobs a end the comment now b4 GRAMMAR NAZI come for me ok like seriously Oma end it sooner or later.... Anytime now like 3.. 2... This game is so good this can't stop talking about likening get the the game uh oh GRAAMMARRR NAZIZIZIIZIZIZIZIZIZIZI runnnnnnnnnnnnnn..…......
Great game BUT......
There's always a but. I have over 10 million coins, over 3500 gems so there is just one more item to accomplish which is near impossible. I've been waiting for further challenges, new screens, items to spend my 10 million coins on. The Bolt character's new threads advertised as a limited time has been up forever. In short without new screens to run the game is fast becoming boring. I am just about done with this game. Moving on to something new and challenging.
Good Game But...
This game is so much fun! Has great thought put into it and just love all the obstacle ideas and great stuff. But... there are WAYY to many glitches. I go to jump on the rope in the very beginning and I fall & die because it's glitches. Also you randomly die sometimes because the game decides to glitch. Also in the very beginning when you click the game to play on your homescreen, it take forever to load before the game ever starts. Please fix these things and give us a new update to make it even better. 😊 Thanks for your time! 😊💚
- Free
- Category: Games
- Updated: Jul 31, 2015
- Version: 1.17
- Size: 88.3 MB
- Language: English
- Seller: Imangi Studios, LLC
- © 2015 Imangi Studios, LLC
Compatibility: Requires iOS 5.1.1 or later. Compatible with iPhone, iPad, and iPod touch.
Top In-App Purchases
- 5 Gem Pack$0.99
- Usain Bolt$0.99
- 5,000 Coin Pack$0.99
- 50 Gem Pack$4.99
- 50,000 Coin Pack$4.99
- 150,000 Coin Pack$9.99
- Coin Doubler$4.99
- 400,000 Coin Pack$19.99
- 150 Gem Pack$9.99
- 500 Gem Pack$19.99


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Unbelievable Softness
By Anonymous
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Comments about Cascade Yarns Eco Duo:
This yarn is incredibly soft and lofty. I love the natural color palate too. This is meant to be snuggled right up against your chin and face, it's just that wonderful. I can't believe it's on closeout. The yardage per hank is amazing too.
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Join | Login
Lacrosse Magazine, owned and published by US Lacrosse, the national governing body of men's and women's lacrosse, is circulated to more than 430,000 members of the organization as one of the benefits of membership. Join Today!
Welcome to the seventh annual US Lacrosse U15 National Championships. The event provides the U15 lacrosse community with the highest levels of national competition and sportsmanship. Twenty-eight girls' teams and 18 boys' teams from 19 states will compete July 24-26, 2015, in Richmond, Va., to crown the best of US Lacrosse's national U15 membership.
Volunteers are welcome to help with the event.
Boys' and girls' at-large teams and Regional Championship semifinalists
Become a Member
National championship tournament with pool play and bracket play
Schedules & Scores
River City Sportsplex
July 23-26, 2015
Field Map
Previous champions, bracket scores, honors
See Event History
Next Level Video will be on site offering professional HD Game Film from elevated positions. Multiple packages are available.
Many of the slots in the US Lacrosse U15 National Championships will be filled by teams that finish in the top four at a regional championship. Those teams also earn discounts on U15 National Championships registration, ranging from 25 to 100 percent.
*Weather permitting
Apply for At-Large Bid


text:
TLC's "19 Kids and Counting" will have to change its name again!
The Duggar Family made a huge announcement on "Today" this morning -- they're pregnant with baby number 20!
"We are so excited," Michelle Duggar says. "I was not thinking that God would give us another one, and we are just so grateful.
Mega-dad Jim Bob joked about the news, saying "I don't know how it happened. We didn't want to stop at an odd number."
45-year-old Michelle says she's not too worried about a pregnancy at her age -- adding "I'm really in better shape than I've been in 20 years."
The new baby is due in April.
Congrats to the HUGE family!
© 2015 EHM Productions, Inc. All rights reserved. Reproduction in whole or in part without permission is prohibited.
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text:
[Hook: Cassie + (Machine Gun Kelly)]
This is a, warning shot
The final call (x2)
This is a (this is a)
Warning shot (warning shot)
The final call (x2)
[Verse 1: Machine Gun Kelly]
Okay I came in, no clout, small bank and my big mouth
Small name but these big shots Know just what this kids 'bout
I said shit, then I meant shit, coroner (I dead shit!)
I treat hoes, just like hoes, that throw bones, go fetch it
I'm pitbull, that 'X' shit, that going in at they neck shit
That 'we gonna have a problem if I am not on they next shit'
'Cause I wreck shit, can't tame me; I'm Eminem and I'm Jay-Z
I'm the renegade of this rap shit, me and all my boys like A Team
Fuck's wrong wit y'all? This is my warning shot I better see you get ghost
Because I'll treat competition like hoes, skip conversation and come at they throats
Boy I'm from the C-L-E-V-E-L-A-N-D and I will be reppin that until I die
And you either with me or riding against me so let me know
Put them L's up in the sky, lace up!
[Verse 2: Machine Gun Kelly]
Call me the man, better yet, call me the kid (Uh)
Cause ain't nobody this young done what I did (No)
Cause ain't nobody this young gone through the shit that I went through these past couple years and lived (Woop)
Y'all suckers; hickey shit
I'm a real rockstar; Nikki Sixx
I'm Minaj and y'all just watch
God damn y'all Nikki's bitch
Can the game get any more corny? (Huh?)
Can the fame get any more boring? (Uh)
Can any other lame who think I'm dope put out garbage and make it easy for me
Is it possible for anyone to ignore me? (No)
Is it possible for anyone to record me?
So I cannot trust other people who capture closed video songs and put them out before me (Ha!)
And is it possible that I possibly delivered the illest lyrics?
Somebody call the paramedics! (Ahhhhh)
Somebody call the fucking paramedics!
Is it even possible with a lack of academics to get the credit in the city and never spend a minute in the class?
Fuck that, kiss my ass
Straight till it's pitch black
Roll it up and let me hit it
[Hook] (x2)
- 1. Warning Shot
- 2. Wild Boy
- 3. See My Tears
- 4. Half Naked and Almost Famous
- 5. EST 4 Life


text:
Come to my christmas bash on 12/20/08 at 8:00 PM Bring your own bottle to build a bar. after 5...
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An elegant ecard for all your loved ones to make them feel special.
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KelseyCare Advantage reports HEDIS scores to the Centers for Medicare and Medicaid Services
Houston, TX (PRWEB) October 6, 2009 -- KelseyCare Advantage, a Houston-based Medicare Advantage plan serving more than 10,000 Medicare beneficiaries in the counties of Harris, Fort Bend, Montgomery, and Galveston on the Mainland, recently reported its Healthcare Effectiveness Data and Information Set (HEDIS) to the Centers for Medicare and Medicaid Services (CMS). KelseyCare Advantage scored high, in the 90th percentile, for comprehensive diabetic care and also scored well in blood pressure control.
HEDIS is a tool that more than 90 percent of health plans in America use to measure performance and quality on important dimensions of care and service. It looks at a broad range of clinical issues such as diabetes care, beta blocker use after heart attack, blood pressure control, asthma medication use and immunization sets. HEDIS scores make it possible to compare performance among health plans, and allow individual health plans to study their own data to determine areas of improvement.
KelseyCare Advantage has an extensive diabetic population. Prevention of hospitalizations, kidney failure, retinopathy, vascular disease and amputations is directly related to the quality of care the diabetic population receives. The high ranking achieved by KelseyCare Advantage demonstrates the delivery of high quality health care to this population.
"Our HEDIS scores show that diabetic patients in the KelseyCare Advantage plan receive high quality care for overall control, cholesterol management and control of blood pressure," said Donald W. Aga, M.D., Medical Director of KelseyCare Advantage. "We are excited about the results of our HEDIS surve
|Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved


text:
Jay High's Ashlyn Geck gets herself out after running into a live ball following a bunt attempt against Chipley during the Region 1-1A title game on Friday night.
Given the regular season history between the two teams, Friday night's Region 1-1A championship game figured to be a rock 'em, sock 'em slugfest between Jay and Chipley.
Instead, the overflow crowd at Jay High was treated to the exact opposite, in every way.
Chipley's Mallory Dean and Jay's Chassity McCranie faced off in a pitcher's duel, and this time it was Dean who got the best of the Royals with an 11-strikeout performance in a 4-1 win in 10 innings over Jay. ...


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Powell Dobson streamline its financial information
Posted on 14 Jul 2014 by Jack Alford in Project News
Powell Dobson Architects invest in Union Square for Project Accounting for a collaborative approach
Powell Dobson is an architectural practice with offices in Cardiff, Swansea and London that views collaborative working as a necessity. In line with this ethos, the practice has selected Union Square for Project Accounting to streamline the management of its finances, as well as improve fee forecasting and resourcing. Committed to providing quality service to users in all of its projects, Powell Dobson believe in clear, efficient communication across its practice, something Union Square has proved it can provide.
"We had a clear understanding that we didn't have enough visibility or control over projects. This meant we had no overview or summary of project performance. We wanted to be able to control the input of project information, in order to improve the quality of data output." Andrew Nixon, Director – Powell Dobson.
Powell Dobson had separate systems for timesheet entry, leave booking, accounting, forecasting and resourcing, all storing separate silos of information. Without effective communication between the systems, time was wasted re-keying data, there was limited control over information, and project visibility was poor. As a director at Powell Dobson, Andrew Nixon wanted to bring the company up to speed with the technology it was using and so began looking for a project accounting system:
"We looked at several systems but we were looking for a modular, integrated system and in this area of expertise, Union Square was head and shoulders above the rest."
With the modular arrangement that Union Square uses, it allows a company to 'bolt on' additional modules at a later date if they want to increase its level of functionality. Andrew was intent on doing away with disparate systems and so initially decided to invest in Project Accounting, with the control and management of projects deemed to be a top priority. But one of the benefits he felt Union Square offered was this ability to choose to expand the system at a later date. Andrew also discussed some of the other qualities the system offers:
"The system is highly intuitive while also being comprehensive and detailed; the user friendly interface is important when new users begin adopting the system. We were also impressed with the level of re-investment going into the company. We wanted a provider we knew we could rely on for years to come, and were comforted in the knowledge that a high level of resource is always going into development and support at Union Square."
Powell Dobson was offered the chance to visit current clients of Union Square to see the system in action. Along with the knowledge of a 37,000 strong user base that Union Square has under its belt, Andrew was convinced that investing in Union Square was the right decision. With implementation well underway, Powell Dobson started by introducing timesheets, leave booking and the contact management system to its users, followed by fee forecasting, reporting and invoicing:
"So far the changeover to Union Square has been extraordinarily effortless, we are looking forward to making use of the rest of the Project Accounting system, with a view to exploring the document management functionality in the future."
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text:
Ultrananocrystalline Diamond
Synthesis, Properties and Applications
- Olga A. Shenderova, International Technology Center, North Carolina, USA
- Dieter M. Gruen, Argonne National Laboratory, Chicago, IL, USA
This work brings together the basic science of nanoscale diamond structures, with detailed information on ultra-nanodiamond synthesis, properties, and applications. The book offers discussion on UNCD in its two forms, as a powder and as a chemical vapor deposited film. Also discussed are the superior mechanical, tribological, transport, electrochemical, and electron emission properties of UNCD for a wide range of applications including MEMS/ NEMS, surface acoustic wave (SAW) devices, electrochemical sensors, coatings for field emission arrays, photonic and RF switching, biosensors, and neural prostheses, etc.
AudienceR&D community (academic and corporate) and engineers in the fields of nanotechnology, materials, thin films, deposition, biomedical engineering, optics, proteomics (protein chip technology in genomics), semiconductors, pharmaceutical, biotechnology and MEMS / NEMS.
Book information
- Published: September 2012
- Imprint: WILLIAM ANDREW
Table of Contents
- Advances in synthesis and processing
- Advances in surface functionalization (Krueger? Hammers?) II.1 Achievements in uniformity of surface groups on DNDII.2 Demonstration of functionalization of DND with a variety of new surface groupsII.3 Demonstration of bioconjugation of DND and UNCD\NCD filmsII.4 Functionalization of onion-like carbon II.5 Demonstration of formation of hybrid structures of DND and UNCD with other nanoscale materialsII.6 Methods of incorporation of DND into polymers matrixes and sol-gels
- Advances in nanodiamond characterization and new insights into the structure of UNCD and DND
I.1 Synthesis of UNCD films
I.1.1 Advances in Synthesis of UNCD and NCD films
I.1.2 Insight on Nucleation of UNCD films
I.1.3 Growth of n-Type UNCD
I.2 Synthesis and Processing of Nanodiamond particles (Danilenko or Dolmatov)
I.2.1 New methods of Nanodiamond synthesis
I.2.2 New approaches in synthesis of detonation ND
I.2.3 Advances in detonation ND deagglomeration and fractionation
I.2.3.1 Deagglomeration of DND to primary particle sizes
I.2.3.2 Fractionation of ND into narrow size distribution fractions
I.2.4 Purification of detonation ND
I.2.4.1 Purification from incombustible impurities
I.2.4.2 Deep purification of DND from non-diamond carbon
III.1 Characterization of UNCD
III.1.1 NEXAFS, etc.
III.1.2 Charge Carriers
III.1.3 Nano-indentation
III.1.4 Laser Ablation
III.2 Characterization of ND particles
III.2.1 Doping of ND particles (Shenderova)
- Studies on N state in ND particles (EELS, EPR, NMR)
- Studies of NV centers in DND
- Atomistic modeling
- Advances in property measurements and emerging applications
IV.1 Properties and Applications of UNCD
IV.1.1 Electrical
- Electronics of UNCD films
- Field Emission of UNCD films
IV.1.2 Electrochemistry of UNCD films
IV.1.3 Mechanical
- Friction and Wear of UNCD films
IV.1.4 Thermal properties and thermoelectrics
IV.1.5 MEMS and Lithography of UNCD films
IV.1.6 Bioapplications of UNCD films
IV.2 Properties and Applications of ND particles
IV.2.1 Optical properties and applications of ND particles (Zvyagin, Plahotnik, Rabeu)
- Photoluminescence from 5-20nm HPHT ND (Taiwan)
- Photoluminescence from DND - NV centers
- Photoluminescence due to surface groups and shells
- Formation of photonic crystals from DND
- Quantum magnetometry and quantum computing


text:
The researchers acknowledge some limitations to their study. "Instead of doing a cross-sectional study like this, where we tested children at various ages, we would prefer to do a longitudinal study that would involve the same kids who'd be followed over the years from childhood through adolescence," Dr. Foxe said. "We also need to find a way to study what is happening with low- and mid-functioning children with ASD. They are much less tolerant of testing and thus harder to study."
According to the researchers, the work highlights the need to develop more effective therapies to help ASD children better integrate audio and visual speech signals. "We are beginning to work on that," said Dr. Foxe.
|Contact: Kim Newman
Albert Einstein College of Medicine


text:
ELITE News
Colorado Heliops and the ELITE TH22 Helicopter AATD are featured in an excellent article about "The New Era of Simulators" in Rotor & Wing this month. Read the digital edition here. Regarding the TH22, Dennis Pierce of Colorado Heliops says: "This sim is the best, the BEST that you can buy for a flight […]Read the rest of this entry >>
WAAS NAV data update
Update your ELITE Core & Premium Version 8.6, PCATD, BATD and AATD software containing the virtual WORLDWIDE Garmin 430 WAAS GPS data with current GPS Data.
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text:
Hi there,
Waving to you all before I disappear as I start my descent down the slippery slope of Hasselblad ownership.
Just completed the purchase of a 2000FC. :o (I can hear the laughter from the back of the forum). Purchased as I want to use the 110 f2.0 & can't justify a 203 Anyway, this is boxed, all original packaging instructions etc unused :o old unsold stock!
Just got to remember not to stick my finger in shutter now :rolleyes:
*search starts for a decent 110*


text:
Moderators: Timko, Solty, Frank Delicious, Blake_T, Fritz, Booter
disc junkie wrote:would yall mind a newbie?!? I have been wanting to learn cribbage. If yall would prefer to keep it with players at your skill that understandable
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text:
About "American Mary" by Farnell
American Mary
Design by Farnell
Looks great on the tee.
dig it.
this is just adorable-love it!
So cute - really intriguing 5$
Good design looks great on the tee
LOVE it!
haha cute
◠‿◠✿
wow~ very cool idea and illo!!
Like it!
Help me with my design..
Something about this is really nice....I like it. The flag could be a little more wavy/have more movement/folds it feels stiff now. 4
cheers for comments, though doing pretty badly so far.


text:
Fire destroys home in Vt.January 21,2014Fire destroys
home in Vt.
BRADFORD Firefighters are investigating a fire that destroyed a home in Bradford.
The Red Cross said a family of five, including two adults and children ages 7, 15 and 17, were unable to return to their home Monday. It sustained considerable damage from the fire.MORE IN Vermont News
MONTPELIER — From the wage gap to the challenge of child care, there is still work to... Full Story
MONTPELIER — New administrative rules approved by lawmakers Thursday will allow medical... Full Story
Moody's, Fitch and Standard & Poor's have reaffirmed the bond ratings that... Full Story
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text:
Skeletor Variant by Dave-WilkinsWatch
©2012-2015 Dave-Wilkins
My Skeletor cover based off of Phillip Tan's Heman cover, the goal was to do an equal and opposing force to his heroic cover-Super happy with this I love me some MOTU!!!
Fantastic work!
Fantastic work!
That's my dude. Big Skelly! Killer job!
One of my childhood heroes! Truly great work!
Awesome details, shading, lighting, colouring, design, background and effects.
I'm very much going to use this as reference to build my Skeletor costume. Freaking amazing work.
Nicely done !
whoo. amazing work. im a big fan of MOTU and skelletor has always been my favorite villain.
The detail on the muscles.
Awesome art. Skeletor is a great character to work with.
Very cool job) Very beautiful)
Skeletor might be the best villain of all time
IMPRESSIVE!!! Now I gotta go search for that He-man variant!
there should be a SUPER button for this...
beautiful! awesome!
amazing piece and gallery!
So powerful pic!great!
The day issue #1 was released, I went from comic shop to comic shop in Tulsa asking if they had and sold out of the variant cover and got dumbfounded looks with "there was a variant?" Now I've finally stumbled onto the proof and no longer have to rely on Internet hearsay.
HAHHAhhahahaa most people think it's still a myth
DUDE!! this is so PERFECT!! I loved MOTU growing up... I was looking around for El Zombo referance and I can across this.... Awesome!! Great work bro
LOL Thanks man I'll bring some prints and stuff when I come up
Damn, this looks badass!
The tragedy of Skeletor is that as badass as he is, at the end of the day he's always just gonna try and take over Eternia with talking apple trees that lie, or giant holographic bears, and in the end he'll get his butt handed to him over the remains of his silly needlessly complicated plan.
As evidence I submit the episode where, finally left to his own devices, Beast Man basically takes over the world in an afternoon by breaking things and hitting people.
As evidence I submit the episode where, finally left to his own devices, Beast Man basically takes over the world in an afternoon by breaking things and hitting people.
Dude, this is awesome!!!!
That is just so perfect. Absolutely love the hands and claws. The power/energy/magic emitting from the staff is also just spot on...