text:
Ahmed J. Davis is a Principal in the Washington, DC, office of Fish & Richardson, a member of the Firm's Compensation Committee, and National Chair of the F&R Diversity Initiative. His practice focuses on complex patent litigation in a range of technical areas, including chemistry, biotechnology, medical devices, and mechanical and electrical engineering. A trial attorney experienced in all phases of litigation, Mr. Davis has been lead counsel in the International Trade Commission and federal district court, has argued before the United States Court of Appeals for the Federal Circuit, and has litigated cases before the United States Court of Federal Claims. He has particular expertise and is the Firm's leading attorney for matters in the "rocket docket" that is the United States District Court for the Eastern District of Virginia.
Mr. Davis regularly speaks and lectures on issues relevant to the patent bar. Since 2008, he has been a faculty member at the ALI-ABA Conference "Trial Of A Patent Case" and, since 2010, a faculty member at the annual PLI Conference on Patent Litigation. He has spoken or been a guest lecturer on patent issues at Howard University Law School, Catholic University Columbus School of Law, Temple Law School, and Fordham Law School. He has presented on patent law at numerous Bar conferences; is a member of the Sedona Conference Working Group on Patent Damages and Royalties (WG9) and the Working Group on Patent Litigation Best Practices (WG10). He is also an instructor for the National Institute of Trial Advocacy (NITA). Mr. Davis also is committed to giving back to the legal community through the development of young lawyers and by increasing diversity within the profession. He is the former pro bono coordinator for the firm's DC office, and he regularly speaks to law students about opportunities in patent law and the importance of judicial clerkships.
Mr. Davis has received numerous accolades and awards for his work. In March 2015, Savoy magazine named him a "Most Influential Black Attorney of 2015." In February 2015, Davis was featured as a Minority Power Broker by Law360, and he was also named one of Profiles in Diversity's Diversity Leaders for 2015. In February 2011, the Washington Business Journal named Davis One of the Top Minority Business Leaders of 2011. In October 2010 The Root, an online publication of the Washington Post, identified Davis as part of the next generation of African-American leaders. In June 2010, Mr. Davis was named a "2010 Nation's Best Advocate: 40 Lawyers under 40," by the National Bar Association and IMPACT. And in July 2009, Mr. Davis was named one of the "40 Under 40: Washington's Rising Stars" by The National Law Journal and an "IP Star" by Managing Intellectual Property in 2015.
Before joining the firm, Mr. Davis was a law clerk for the Honorable Leonie M. Brinkema in the Alexandria Division of the United States District Court for the Eastern District of Virginia (1999-2000). He also was a law clerk for the Honorable Paul R. Michel at the United States Court of Appeals for the Federal Circuit (2001-2002).
Mr. Davis is on the Board of Directors of D.C. Legendary Musicians, Inc. and on the Board of Directors for the Living Classrooms Foundation in Washington, DC, and is a Deacon at Montgomery Baptist Church in Gaithersburg, MD.
JD, Georgetown University Law Center 1999
MS, Emory University 1996
BS, Morehouse College 1994
cum laude
- District of Columbia
- Virginia
- United States District Court for the Eastern District of Virginia
- United States District Court for the Eastern District of Michigan
- United States District Court for the District of Maryland
- United States Court of Federal Claims
- United States Court of Appeals for the Federal Circuit
- United States Court of Appeals for the Fourth Circuit
The Honorable Leonie M. Brinkema, 1999 - 2000
The Honorable Paul R. Michel, 2001 - 2002
Other Distinctions
- Ahmed Davis and Jack Brennan, "Timing of PTO Disclosures – A Trap for the Unwary," Pharmaceutical Compliance Monitor, December 20, 2013.
- Ahmed Davis, guest blogger for NITA's The Legal Advocate blog, launches the February series on "Diversity in the Courtroom." Read his first post, "Diversity in the Courtroom Part 1 – Jury Pool Biases." (February 6, 2013)
- Ahmed Davis and Karolina Jesien. "The Balance of Power in Patent Law: Moving Towards Effectiveness in addressing Troll Concerns." Fordham Intellectual Property Media & Entertainment Law Journal Vol. 22 (2012): 835-850.
- Davis, Ahmed. "Stand by me: Subsidiary patent assignments and their impact on damages and constitutional standing," National Bar Association Corporate Newsletter, February 2012.
- International Intellectual Property Institute, Study on Specialized Intellectual Property Courts, January 2012.
Speaking Engagements/Lectures
- National Bar Association Corporate Counsel Conference (Naples, FL, February 2015 ("Leveraging IP")
- ABA Litigation Roundtable Weebinar (Washington, DC February 2015) (Reasonable Royalties and Damages)
- The 15th Annual Sedona Conference on Patent Litigation (New Orleans, LA, November 2014)
- Association of Corporate Patent Counsel Summer Meeting (Chicago, June 2014) ("Hot Topics In Patent Law")
- The 14th Annual Sedona Conference on Patent Litigation (Del Mar, CA, October 2013)
- National Bar Association 88th Annual Convention (Miami, July 2013) (scheduled)
- American Law Institute-American Bar Association Conference: "Trial Of A Patent Case" (New York, May 2013)
- 11th Annual Rocky Mountain Intellectual Property & Technology Institute (Colorado, May 2013) ("Practice Before The ITC")
- Patent Law Institute: Patent Litigation 2012 (Chicago, October 2012) ("Trends In ITC Practice")
- National Disability Rights Network Annual Convention (Baltimore, June 2012) (instructor, NITA deposition skills training course)
- ABA Litigation Section Meeting (Washington, April 2012)("Litigating in the Digital Age: Tech Tips To Propel Your Case To Success")
- National Society of Black Engineers, Annual Conference (Pittsburgh, March 2012) ("Careers In IP Law")
- Federal Circuit Bar Association, Webcast (Washington, February 2012) ("E-Discovery Model Order: A Practitioner's Perspective")
- International Intellectual Property Institute: Seminar on Specialized IP Rights Courts (Virginia, January 2012) ("Bring in the Experts: The Role of Judges and Court-Appointed Experts With Technical Knowledge")
- Guest Lecturer on Patent Litigation, Catholic University Columbus School of Law (November 2011)
- Fordham Law School Symposium "IP Bullying Or Proactive Enforcement?" (New York, November 2011) ("The Balance of Power In Patent Law")
- Patent Law Institute: Patent Litigation 2011 (Chicago, October 2011) ("Trends In ITC Practice")
- American Law Institute-American Bar Association Conference: "Trial Of A Patent Case" (Chicago, October 2011)
- United States Patent and Trademark Office, Senior Executive Service Council Meeting (Virginia, April 2011) (The Importance of Diversity in IP Law)
- American Law Institute-American Bar Association Conference: "Trial Of A Patent Case" (New York, October 2010)
- PLI: Patent Litigation 2010 (Northern Virginia, October 2010) ("Pre-litigation and litigation strategies against NPEs")
- Howard University Law School IP Empowerment Summit (Washington, DC November 2010) (IP pro bono programs in underserved communities)
- National Bar Association, Annual Conference (New Orleans, August 2010) (Improving Pitch Skills)
- ABA Litigation Section Meeting (New York, April 2010)("Keep It Simple: Presenting IP Cases to a Jury")
- Temple Law School symposium "The Greening of Intellectual Property" (March 2010) (measuring the impact of In re Bilski)
- National Bar Association, Annual Conference (San Diego, August 2009) (Post-Trial Damages)
- American Law Institute-American Bar Association Conference: "Trial Of A Patent Case" (Phoenix, February 2008)
- Minnesota Bar CLE seminar "Patent Enforcement and Defense" (Minneapolis, May 2008)(written description and enablement)
- IP Law and Business: Innovations in IP Litigation Conference (Washington, DC November 2006) (the effective use of reexamination proceedings)
Virginia E-Commerce Solutions, LLC v. eBay, Inc. and PayPal, Inc. (E.D. Va. 2010). Representing defendants eBay and PayPal in case relating to systems for and methods of conducting transnational e-commerce.
Spansion LLC v. Samsung Electronics Co., Ltd. et al. (E.D. Va. 2010). Representing Samsung defendants in case relating to methods of fabricating semiconductor memory devices.
W.L. Gore & Assoc., Inc. v. Medtronic, Inc., et al. (E.D. Va. 2010). Representing plaintiff W.L. Gore in case relating to intraluminal stent grafts.
BioElectronics Corp. v. 709702 BC Ltd. and Psaila (D. Md. 2010). Representing plaintiff BioElectronics in trademark infringement litigation in case related to Actipatch dermal patches.
Webmap Technologies Inc. v. Microsoft Corp. et al. (E.D. Tex. 2009). Represented defendant Microsoft in patent case related to web-based interactive mapping systems. Case settled favorably.
Entrust, Inc. v. Corel Corp. (E.D. Va. 2006). Represented defendant Corel in software copyright infringement case. Obtained case dismissal.
Ford Motor Co. v. Paice LLC (E.D. Mich. 2006). Represented declaratory judgment defendant Paice LLC in case related to hybrid electric vehicles. Successfully obtained case dismissal.
Repligen et al. v. Bristol-Myers Squibb (E.D. Tex. 2006). Represented plaintiffs Repligen and the Regents of the University of Michigan in case relating to treatment of rheumatoid arthritis. Obtained highly favorable settlement.
American Calcar v. American Honda Motor Co., et al. (S.D. Cal. 2006). Representing Honda defendants in case relating to vehicle telematics. After obtaining case transfer from E.D. Tex., prevailed on summary judgment and at trial on 13 of 15 asserted patents. Case currently on appeal to Federal Circuit.
Saunders Group, Inc. v. ComforTrac and Care Rehab and Orthopaedic Products (E.D. Va. 2005). Lead counsel for defendants ComforTrac and Care Rehab and Orthopaedic Products in case relating to cervical traction devices. Obtained highly favorable settlement.
Paice LLC v. Toyota Motor Corp. et. al. (E.D. Tex. 2004, 2007). Represented plaintiff-patentee Paice LLC in cases related to control systems for hybrid electric vehicles. Obtained jury verdict of infringement and no invalidity, and a past damages award of over $ 5 million. In damages aspect of case remanded for additional proceedings related to ongoing royalty, jury's per car royalty award was quadrupled.
International Trade Commission
In re Certain InkJet Ink Cartridges (U.S.I.T.C. 2010). Representing complainants Hewlett-Packard Co. and Hewlett-Packard Development Co. in Inv. No. 337-TA-723 related to thermal inkjet print cartridges.
In re Certain InkJet Ink Supplies (U.S.I.T.C. 2009). Representing complainants Hewlett-Packard Co. and Hewlett-Packard Development Co. in Inv. Nos. 337-TA-691 and 337-TA-730 related to thermal inkjet print components. Obtained default judgment; motion for general exclusion order pending.
In re Certain Hybrid Electric Vehicles (U.S.I.T.C. 2009). Represented complainant Paice LLC against Toyota Motor Corp. et al. in Inv. No. 337-TA-688 related to high-voltage and low-current hybrid electric vehicle drive systems. Obtained highly favorable settlement on the eve of trial.
In re Certain Vein-Harvesting Surgical Systems (U.S.I.T.C. 2008). Represented Respondent Terumo in Inv. No. 337-TA-645 related to apparati for and methods of performing surgical procedures. Case settled favorably shortly before trial.
In re Certain Unified Communications Systems and Components Thereof (U.S.I.T.C. 2007). Represented respondent Microsoft Corp. in Inv. No. 337-TA-598 in case related to unified communications systems. Case settled favorably during Federal Circuit appeal.
In re Certain Flash Memory Devices and Components Thereof (U.S.I.T.C. 2005). Represented respondent Hynix Semiconductor, Inc. in Inv. No. 337-TA-552 in case related to flash memory devices. Final Determination of noninfringement of both asserted patents.
In re Certain Light-Emitting Diodes (U.S.I.T.C. 2004). Represented complainants OSRAM GmbH and OSRAM Opto Semiconductors GmbH in Inv. No. 337-TA-512 in case related to light-emitting diodes (LEDs). Obtained limited exclusion order prohibiting respondent Dominant Semiconductor from importing all accused LEDs into the United States.
In re Certain Display Controllers (U.S.I.T.C. 2003). Represented complainant Genesis Microchip, Inc. in Inv. No. 337-TA-491. Obtained limited exclusion order against all respondents.
What's trending with Ahmed
Filter by
May 26, 2015
Fish Named a "Top Firm" for Minority Attorneys by Law360
March 10, 2015
Fish & Richardson Principal Ahmed J. Davis Named a "Most Influential Black Lawyer" for 2015 by Savoy Magazine
March 9, 2015
Fish & Richardson Announces 2015 1L Diversity Fellows
February 11, 2015
Minority Powerbrokers Q&A with Fish's Ahmed Davis
February 3, 2015
Fish & Richardson Principal Ahmed J. Davis Receives 2015 "Diversity Leader" Award
November 20, 2014
Fish & Richardson Receives "Best Place to Work" Designation from the Human Rights Campaign
June 19, 2014
Fish Ranks in Top 15 Percent of Law Firms for Diversity
December 20, 2013
Timing of PTO Disclosures – A Trap for the Unwary
May 29, 2013
Helping Young and Diverse Minority Attorneys Prosper
April 9, 2012
Fish & Richardson Announces 2012 Diversity Fellows
February 23, 2011
Ahmed Davis Selected as One of the Top Minority Business Leaders of 2011 by the Washington Business Journal
October 12, 2010
Fish's Davis Named an Honoree of the Root 100, The Root.com's Annual List of a Generation of African-American Leaders


text:
|Accession Numbers: G85 (MetaCyc), b2407, ECK2401
Synonyms: pndA, purine nucleoside phosphorylase II
Species: Escherichia coli K-12 substr. MG1655
Subunit composition of
xanthosine phosphorylase = [XapA]6
xanthosine phosphorylase = XapA
Xanthosine phosphorylase (XapA or PNP-II) is one of two purine nucleoside phosphorylases (PNPs) in E. coli. PNPs use orthophosphate to cleave the N-glycosidic bond of the β-(deoxy)ribonucleosides to produce α-(deoxy)ribose1-phosphate and the free purine base. The bases can be utilized as precursors in the synthesis of nucleotides in the purine salvage pathways, as well as a nitrogen source. The pentose-1-phosphate formed serves as a carbon source. The other PNP, PNP-I purine nucleoside phosphorylase, differs in substrate specificity.
XapA does not cleave or synthesize adenosine and deoxyadenosine but catalyzes the phosphorolysis of xanthosine, inosine and guanosine with comparable efficiency. Therefore, this enzyme has been variously referred to as xanthosine phosphorylase and inosine-guanosine phosphorylase [Koszalka88, Dandanell05]. XapA enables E. coli to grow on xanthosine as the sole source of carbon [HammerJespersen80, Seeger95]. The amino acid sequence of XapA resembles that of mammalian purine nucleoside phosphorylases and has no similarity with PNP-I [Dandanell05].
Recently, an investigation of the NAD+ salvage pathway showed that a ΔnadC pncA double mutant can grow slowly in M9 minimal medium containing nicotinamide (NAM). This implied the presence of a previously undefined activity that routes NAM into NAD+synthesis. An additional mutation in xapA further decreased growth of the ΔnadC pncA mutant on NAM, and purified XapA was shown to catalyze formation of nicotinamide riboside from nicotinamide at low efficiency [Dong14].
XapA predominantly exists as a hexamer with some evidence for co-existence of a trimeric from [Dandanell05, HammerJespersen80]. Crystal structures of XapA were solved in the presence of guanine and phosphate as well as xanthine and sulfate. XapA forms a hexamer in a dimer-of-trimers conformation in the crystal structure [Dandanell05]. A Y191L mutation in the active site resulted in no detectable activity of XapA against xanthosine, although it retained activity against inosine and guanosine with altered affinities and reduced maximal velocities, while an N239D mutation changed the substrate specificity to adenosine [Dandanell05].
A genetic engineering study was directed at inosine production using a xapA mutant. It was concluded that due to apparent regulatory features in E. coli, other engineered organisms show higher inosine production [Shimaoka06].
XapA from E. coli K-12 can also catalyze the degradation of the synthetic xenobiotic substrate 5-nitrobenzisoxazole by the Kemp elimination mechanism, which is not known to occur in biological systems. This property has been demonstrated in enzyme engineering studies [Khersonsky11].
The XapR-xanthosine DNA-binding transcriptional activator and the presence of the inducer xanthosine in the growth medium are required for full expression of XapA [HammerJespersen80, Jorgensen99]. Regulatory mutants were first isolated as second-site revertants of a deoD mutant that were able to catabolize purine ribonucleosides [Buxton80]. A xapA mutant can no longer grow on xanthosine as the sole source of carbon [Seeger95].
Xap: "xanthosine phosphorylase" [Buxton80]
Review: [Kulikowska04]
Citations: [Bezirdzhian86, Kocharian86, Bezirdzhian87a, Bezirdzhian87, Konrad12]
Locations: cytosol
|Map Position: [2,522,067 <- 2,522,900]
Molecular Weight of Polypeptide: 29.835 kD (from nucleotide sequence), 30.1 kD (experimental) [Seeger95 ]
Molecular Weight of Multimer: 205.0 kD (experimental) [HammerJespersen80]
Unification Links: ASAP:ABE-0007927 , CGSC:9 , EchoBASE:EB4152 , EcoGene:EG20250 , EcoliWiki:b2407 , Entrez-gene:946878 , ModBase:P45563 , OU-Microarray:b2407 , PortEco:xapA , PR:PRO_000024228 , Protein Model Portal:P45563 , RefSeq:NP_416902 , RegulonDB:G85 , SMR:P45563 , String:511145.b2407 , UniProt:P45563
Relationship Links: InterPro:IN-FAMILY:IPR000845 , InterPro:IN-FAMILY:IPR001369 , InterPro:IN-FAMILY:IPR010943 , InterPro:IN-FAMILY:IPR011268 , InterPro:IN-FAMILY:IPR018099 , Panther:IN-FAMILY:PTHR11904 , PDB:Structure:1YQQ , PDB:Structure:1YQU , PDB:Structure:1YR3 , Pfam:IN-FAMILY:PF01048 , Prosite:IN-FAMILY:PS01240
Instance reactions of [a purine ribonucleoside + phosphate ↔ a purine base + α-D-ribose-1-phosphate] (18.104.22.168):
GO Terms:
|Biological Process:
|GO:0006148 - inosine catabolic process
[Koszalka88, Shimaoka06, Dandanell05]
GO:0006149 - deoxyinosine catabolic process [Koszalka88]
GO:0006152 - purine nucleoside catabolic process [Seeger95, Koszalka88, Shimaoka06, Dandanell05, Jorgensen99]
GO:0006161 - deoxyguanosine catabolic process [Koszalka88]
GO:0015949 - nucleobase-containing small molecule interconversion [Seeger95]
GO:0034214 - protein hexamerization [Dandanell05]
GO:0034355 - NAD salvage [Dong14]
GO:0046115 - guanosine catabolic process [Koszalka88, Dandanell05]
GO:0055086 - nucleobase-containing small molecule metabolic process [GOA01a, Seeger95]
GO:1903228 - xanthosine catabolic process [Seeger95]
GO:0006139 - nucleobase-containing compound metabolic process [GOA01a]
GO:0009116 - nucleoside metabolic process [GOA01a]
GO:0043101 - purine-containing compound salvage [Gaudet10]
|Molecular Function:
|GO:0004731 - purine-nucleoside phosphorylase activity
[GOA01, GOA01a, Seeger95, Koszalka88, Shimaoka06, Jorgensen99, Dandanell05]
GO:0042802 - identical protein binding [HammerJespersen80]
GO:0047724 - inosine nucleosidase activity [Koszalka88, Shimaoka06, Dandanell05]
GO:0047975 - guanosine phosphorylase activity [Koszalka88, Dandanell05]
GO:0003824 - catalytic activity [GOA01a]
GO:0016740 - transferase activity [UniProtGOA11a]
GO:0016757 - transferase activity, transferring glycosyl groups [UniProtGOA11a]
GO:0016763 - transferase activity, transferring pentosyl groups [GOA01a]
|Cellular Component:
|GO:0005737 - cytoplasm
[GOA01a, Dandanell05]
GO:0005829 - cytosol [DiazMejia09]
|MultiFun Terms:
|metabolism → central intermediary metabolism → nucleotide and nucleoside conversions
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
Enzymatic reaction of: xanthosine phosphorylase
Synonyms: purine nucleoside phosphorylase
xanthosine + phosphate <=> α-D-ribose-1-phosphate + xanthine
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
The reaction is physiologically favored in the direction shown.
In Pathways: purine nucleotides degradation II (aerobic) , xanthine and xanthosine salvage , urate biosynthesis/inosine 5'-phosphate degradation , purine ribonucleosides degradation
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
Kinetic Parameters:
pH(opt) (forward direction): 5.8-7.2 [Dandanell05]
pH(opt) (reverse direction): 5.5-8 [Dandanell05]
Enzymatic reaction of: inosine phosphorylase (xanthosine phosphorylase)
Synonyms: purine nucleoside phosphorylase
inosine + phosphate <=> hypoxanthine + α-D-ribose-1-phosphate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
The reaction is physiologically favored in the direction shown.
Alternative Substrates for inosine: 2'-deoxyinosine [HammerJespersen80 ]
Alternative Products for α-D-ribose-1-phosphate: deoxyribose 1-phosphate [Koszalka88 ]
In Pathways: purine nucleotides degradation II (aerobic) , adenine and adenosine salvage III , adenosine nucleotides degradation II , purine ribonucleosides degradation
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
Apparent activation energies in the phosphorolytic and synthetic direction are 11.5 Kcal/mol and 7.9 Kcal/mol respectively [Koszalka88].
The enzyme can catalyze the reverse reaction, synthesis of inosine, in vitro [HammerJespersen80, Koszalka88].
Kinetic Parameters:
pH(opt) (forward direction): 6.6 [Koszalka88]
pH(opt) (reverse direction): 6.8 [Koszalka88]
Enzymatic reaction of: guanosine phosphorylase (xanthosine phosphorylase)
Synonyms: purine nucleoside phosphorylase
EC Number: 126.96.36.199
guanosine + phosphate <=> guanine + α-D-ribose-1-phosphate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
The reaction is physiologically favored in the direction shown.
Alternative Substrates for guanosine: 2'-deoxyguanosine [Buxton80 ]
In Pathways: purine nucleotides degradation II (aerobic) , superpathway of guanine and guanosine salvage , guanosine nucleotides degradation III , guanine and guanosine salvage , purine ribonucleosides degradation
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
Kinetic Parameters:
pH(opt) (forward direction): 6.5-7.5 [Dandanell05]
pH(opt) (reverse direction): 6.5-8 [Dandanell05]
Enzymatic reaction of: nicotinamide riboside phosphorylase (xanthosine phosphorylase)
EC Number: 2.4.2.-
nicotinamide + α-D-ribose-1-phosphate + H+ <=> 1-(β-D ribofuranosyl)nicotinamide + phosphate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Reversibility of this reaction is unspecified.
Imported from EcoCyc 02-Jun-2015 by Paley S , SRI International
Kinetic Parameters:
|Feature Class
|85 -> 87
10/20/97 Gene b2407 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene G85.
Bezirdzhian86: Bezirdzhian KhO, Kocharian ShM, Akopian ZhI (1986). "[Isolation of the hexameric form of purine nucleoside phosphorylase from E. coli. Comparative study of trimeric and hexameric forms of the enzyme]." Biokhimiia 1986;51(7);1085-92. PMID: 3089333
Bezirdzhian87: Bezirdzhian KhO, Kocharian ShM, Akopian ZhI (1987). "[Hexamere purine nucleoside phosphorylase from Escherichia coli K-12. Kinetic analysis and mechanism of reaction]." Biokhimiia 52(11);1770-6. PMID: 3125860
Bezirdzhian87a: Bezirdzhian KhO, Kocharian ShM, Akopian ZhI (1987). "[Hexameric purine nucleoside phosphorylase II from Escherichia coli K-12. Physico-chemical and catalytic properties and stabilization with substrates]." Biokhimiia 1987;52(10);1624-31. PMID: 3122852
Buxton80: Buxton RS, Hammer-Jespersen K, Valentin-Hansen P (1980). "A second purine nucleoside phosphorylase in Escherichia coli K-12. I. Xanthosine phosphorylase regulatory mutants isolated as secondary-site revertants of a deoD mutant." Mol Gen Genet 179(2);331-40. PMID: 7007808
Dandanell05: Dandanell G, Szczepanowski RH, Kierdaszuk B, Shugar D, Bochtler M (2005). "Escherichia coli purine nucleoside phosphorylase II, the product of the xapA gene." J Mol Biol 348(1);113-25. PMID: 15808857
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Dong14: Dong WR, Sun CC, Zhu G, Hu SH, Xiang LX, Shao JZ (2014). "New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide." BMC Microbiol 14;29. PMID: 24506841
Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431
GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.
GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."
HammerJespersen80: Hammer-Jespersen K, Buxton RS, Hansen TD (1980). "A second purine nucleoside phosphorylase in Escherichia coli K-12. II. Properties of xanthosine phosphorylase and its induction by xanthosine." Mol Gen Genet 1980;179(2);341-8. PMID: 7007809
Jorgensen99: Jorgensen C, Dandanell G (1999). "Isolation and characterization of mutations in the Escherichia coli regulatory protein XapR." J Bacteriol 181(14);4397-403. PMID: 10400599
Khersonsky11: Khersonsky O, Malitsky S, Rogachev I, Tawfik DS (2011). "Role of chemistry versus substrate binding in recruiting promiscuous enzyme functions." Biochemistry 50(13);2683-90. PMID: 21332126
Kocharian86: Kocharian ShM, Melkumian MA (1986). "[Genetic analysis of Escherichia coli K-12 mutants defective for the structural and regulatory genes for second purine nucleoside phosphorylase]." Genetika 22(8);2055-65. PMID: 3095187
Konrad12: Konrad A, Piškur J, Liberles DA (2012). "The evolution of catalytic residues and enzyme mechanism within the bacterial nucleoside phosphorylase superfamily 1." Gene 510(2);154-61. PMID: 22967797
Koszalka88: Koszalka GW, Vanhooke J, Short SA, Hall WW (1988). "Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12." J Bacteriol 170(8);3493-8. PMID: 3042752
Kulikowska04: Kulikowska E, Kierdaszuk B, Shugar D (2004). "Xanthine, xanthosine and its nucleotides: solution structures of neutral and ionic forms, and relevance to substrate properties in various enzyme systems and metabolic pathways." Acta Biochim Pol 51(2);493-531. PMID: 15218545
Seeger95: Seeger C, Poulsen C, Dandanell G (1995). "Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli." J Bacteriol 177(19);5506-16. PMID: 7559336
Shimaoka06: Shimaoka M, Takenaka Y, Mihara Y, Kurahashi O, Kawasaki H, Matsui H (2006). "Effects of xapA and guaA disruption on inosine accumulation in Escherichia coli." Biosci Biotechnol Biochem 70(12);3069-72. PMID: 17151449
Tomisek65: Tomisek AJ, Hoskins AP, Reid MR (1965). "Chromatographic studies of purine metabolism. VI. Inhibition of inosine phosphorylase by 6-mercaptopurine." Cancer Res 25(11);1925-32. PMID: 5323535
UniProt12b: UniProt Consortium (2012). "UniProt version 2012-11 released on 2012-11-26 00:00:00." Database.
UniProt15: UniProt Consortium (2015). "UniProt version 2015-01 released on 2015-01-16 00:00:00." Database.
UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."
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subset: commoncrawl


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I thought this cereal was okay, just didn't have a lot of flavor. I don't even taste anything remotely similar to apples. I added a bunch of cinnamon to make it better.


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University of Washington (UW) researchers are helping to write the operating manual for the nano-scale machine that separates chromosomes before cell division. The apparatus is called a spindle because it looks like a tiny wool-spinner with thin strands of microtubules or spindle fibers sticking out. The lengthening and shortening of microtubules is thought to help push and pull apart chromosome pairs.
Understanding how this machine accurately and evenly divides genetic material is essential to learning why its parts sometimes fail. Certain cancers or birth defects, like Down syndrome or Trisomy 18, result from an uneven distribution of chromosomes.
In a study published March 6 in the journal Cell, a team led by UW scientists reports on the workings of a key component of this machine. Named a kinetochore, it is a site on each chromosome that mechanically couples to spindle fibers.
"Kineochores are also regulatory hubs," the researchers noted. "They control chromosome movements through the lengthening and shortening of the attached microtubules. They sense and correct errors in attachment. They emit a "wait" signal until the microtubules properly attach." Careful control over microtubules, they added, is vital for accurate splitting of the chromosomes.
The lead researchers on the study were Andrew F. Powers and Andrew D. Frank from the UW Department of Physiology and Biophysics and Daniel R. Gestaut, from the UW Department of Biochemistry. The senior authors of the study were Charles "Chip" Asbury, assistant professor, and Linda Wordeman, associate professor, both of physiology and biophysics and both members of the UW Center for Cell Dynamics; and Trisha Davis, professor of biochemistry, and director of the Yeast Resource Center.
Asbury is known for research on molecular machines and motors, Wordeman for work on chromosome movement, and Davis for studies of spindle poles. All are part of the Seattle Mito
|Contact: Leila Grau
University of Washington


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Be happy at this Howard Johnson Grand Forks ND conveniently located off Interstate 29 near hockey at Ralph Engelstad Arena, and Grand Forks International Airport with complimentary shuttle service. Take the family to explore the great outdoors at The Greenway along the Red River. The North Dakota Museum of Art is just one mile from this lodging with complimentary car and large-vehicle parking. Enjoy drinks at the onsite lounge, sandwiches at the 24-hour lobby market, and complimentary Rise and Dine continental breakfast each morning. Energize in the fitness center, or have fun at the onsite Splash Island Water Park. Host an event in the meeting and banquet facilities, and take advantage of the computer, printer, copy and fax machine available for your convenience. Connect to complimentary wireless Internet access from the comfort of your guest room. Hot tub suites, smoke-free and handicapped-accessible rooms are also available. Pets are welcome at this lodging.Wyndham Hotel Group
24 hour front desk
Free airport shuttle
ATM on-site
Business center
Complimentary breakfast
Express check out
Fitness center
Game room
Hot tub
Indoor pool
Laundry service
Meeting/Banquet facilities
Non-smoking rooms available
Free parking
Pets allowed on request. Charges may apply.
Pool table
Wheelchair accessible
Room service
Storage available
Free Wi-Fi
Get Rates
Get Flight + Hotel


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On a night when sports and politics went 1-on-1, name recognition scored few points with voters.
Linda McMahon, linked with her husband to pro wrestling's world of slams and smackdowns, lost her U.S. Senate race in Connecticut — again.
Connie Mack IV, who carries one of the most venerated names in baseball, was defeated in a bid for a Senate seat in Florida.
George Allen, with familial links to the Washington Redskins past and present, also was blocked from the Senate.
Ben Chandler, the grandson of onetime baseball commissioner Happy Chandler, was out of his U.S. House seat in Kentucky.
Tuesday was hardly an All-Star night for sports. Long gone are the days when the likes of basketball's Bill Bradley served in the Senate. More recently, football's J.C. Watts and track's Jim Ryun were in Congress.
Two years ago, Hall of Fame pitcher and Kentucky Sen. Jim Bunning retired. This year, sports lost more of its sizzle in Congress: Wisconsin Sen. Herb Kohl, the owner of the Milwaukee Bucks, retired, and North Carolina Rep. Heath Shuler, a one-time NFL quarterback, chose not to run again after his district was redrawn.
McMahon, a Republican who once ran World Wrestling Entertainment with blustery husband Vince McMahon, was beaten by Democrat Chris Murphy. She also lost in 2010, and the two defeats came with a hefty check — nearly $100 million from her personal treasury.
Murphy, a three-term congressman, made an issue of the 64-year-old McMahon's wrestling roots, dismissing the enterprise as a vulgar and violent spectacle that belittled women.
"I think that not every CEO is qualified to be a United States senator," he said.
WWE, as the wrestling extravaganza is now known, tried to clean up its image during the Senate campaign in an attempt to make itself more presentable as family fare. Still, Democrats found ways to remind the electorate of an online scene featuring a wrestler simulating sex with a corpse in a casket.
Mack, the great-grandson of Hall of Fame manager Connie Mack, was beaten by Democrat Bill Nelson, who won a third term.
Mack has made much of his baseball lineage. On his web page, the "O" in his first name is replaced with a baseball. The congressman's great-grandfather managed the Philadelphia Athletics for 50 years, starting in 1901, and with his suit and straw hat was always an impeccable presence in the dugout.
The younger Mack's reputation was hit hard in TV ads. Nelson depicted Mack as a bar brawling party-boy. In 1992, Mack was involved in a barroom brawl with then-Atlanta Braves outfielder Ron Gant. Mack insisted he was sober and minding his own business.
Ben Chandler's grandfather was commissioner from 1945-51, a period when Jackie Robinson joined the Dodgers and broke the game's racial barrier. Ben Chandler, a fiscally conservative Democrat, lost to Republican Andy Barr, who linked his opponent to the president in a state where Barack Obama is decidedly weak.


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David John Mullan appeared at Fermanagh Court and admitted committing the burglary.
A prosecutor explained that on July 30, last year, the Belmore Court contacted police to say that a fortnight earlier, on July 8, Mullan had forced his way into a guest's bedroom, causing £300 worth of damage to the door. He had spent the night in the room and left wearing a jacket belonging to the guest, who was away over night.
The court heard that Mullan had come into the motel earlier that night claiming he was looking for his grandparents' room. The motel had no record of his grandparents staying there. He spent 40 minutes sitting in the lobby, during which time his wallet fell out of his pocket with his name on it. He then left and was caught on CCTV walking around the back of the motel and leaving at 8.40am wearing the guest's jacket. The owner of the motel made contact with him and gave him time to pay for the damage. However, when there was no contact from Mullan the police were called in. Mullan told them he had been "on the drink" for two days, his mobile phone had a flat battery and he had no way of contacting anyone. He didn't remember taking the jacket but when he got home he had a jacket. It was returned to the guest, who was from Europe.
Defence barrister Heather Philips said Mullan lived in Newtownards and had been in Enniskillen with a number of friends, from whom he became separated. The battery of his mobile phone was flat and he had no way of contacting them. He went to the motel, believing his grandparents were staying there.
District Judge John Meehan referred to a previous conviction on Mullan's criminal record when he was ordered to pay £423 compensation after taking a taxi and failing to pay the fare.
The District Judge told the court that with or without drink Mullan "does engage in very bizarre behaviour" and this was a "similar sort of bluff and duplicity".
He said the motel had behaved with "more than magnaminity" by saying: "Pay for the door and we'll leave it at that."
Miss Philips said Mullan had instructed her that he was in a position to pay the money but hadn't done so.
However, after checking with Mullan, who was sitting at the back of the court, she conceded that he didn't have the cash.
The case was adjourned to Dungannon Court on February 8.


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I picked up a Velbon Sherpa 750. I'm not sure what the US name is for this tripod. Why do names get changed by US distributors??? [Might be the Velbon Chaser EFL-4 The specs match] It's rated at 12lbs. My monorail and a lens is pretty close to that and the tripod easily handles it. It's relatively cheap. If it is the chaser it's less then $100 at B&H in the US. It goes on sale around here every so often.
The velbon docs call it a "pro" tripod. I consider that a bit much. It's nice enough but I wonder how many pros would love the thing.


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Global warming is likely already taking a toll on world wheat and corn production, according to a new study led by Stanford University researchers. But the United States, Canada and northern Mexico have largely escaped the trend.
"It appears as if farmers in North America got a pass on the first round of global warming," said David Lobell, an assistant professor of environmental Earth system science at Stanford University. "That was surprising, given how fast we see weather has been changing in agricultural areas around the world as a whole."
Lobell and his colleagues examined temperature and precipitation records since 1980 for major crop-growing countries in the places and times of year when crops are grown. They then used crop models to estimate what worldwide crop yields would have been had temperature and precipitation had typical fluctuations around 1980 levels.
The researchers found that global wheat production was 5.5 percent lower than it would have been had the climate remained stable, and global corn production was lower by almost 4 percent. Global rice and soybean production were not significantly affected.
The United States, which is the world's largest producer of soybeans and corn, accounting for roughly 40 percent of global production, experienced a very slight cooling trend and no significant production impacts.
Outside of North America, most major producing countries were found to have experienced some decline in wheat and corn (or maize) yields related to the rise in global temperature. "Yields in most countries are still going up, but not as fast as we estimate they would be without climate trends," Lobell said.
Lobell is the lead author of a paper about the research to be published May 5 online in Science Express.
Russia, India and France suffered the greatest drops in wheat production relative to what might have been with no global warming. The largest comparative loss
|Contact: Louis Bergeron
Stanford University


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Personal tools
More than a just a place where people live, New London is unique and vibrant. This community is home to friends and neighbors, people who contribute to the excellent quality of life. But its not just the people, but also the government, the businesses, the schools, and the activities that make us a great place to live or visit. We are proud to call this our home. Use the links at the left to find demographic information about our city and to explore web sites for our city and county.


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"Merry Christmas, George Bailey" returns to Utah
Published November 13, 2012 5:36 pm
This is an archived article that was published on sltrib.com in 2012, and information in the article may be outdated. It is provided only for personal research purposes and may not be reprinted.
Back by popular demand comes "Merry Christmas, George Bailey," adapted from the classic movie, "It's a Wonderful Life."
This play staged in a radio studio arrives just in time for the holiday season.Adapted, produced, and directed by Dr. Shirlee H. Shields, the play features Bob Bedore, Julie Blatter, Richard Scharine, Neal Barth, and Tom Drury.Performances are Nov. 29, 30, and Dec. 1 at 7 p.m.at the Babcock Theatre, located below the Pioneer Memorial Theatre on the University of Utah campus.Tickets are available at the Kingsbury Hall box office. Call 801-581-7100 or visit http://www.kingtix.com to reserve now.
Tickets are $10 adults and $7 students, plus handling charge.
Reader comments on sltrib.com are the opinions of the writer, not The Salt Lake Tribune. We will delete comments containing obscenities, personal attacks and inappropriate or offensive remarks. Flagrant or repeat violators will be banned. If you see an objectionable comment, please alert us by clicking the arrow on the upper right side of the comment and selecting "Flag comment as inappropriate". If you've recently registered with Disqus or aren't seeing your comments immediately, you may need to verify your email address. To do so, visit disqus.com/account.comments powered by Disqus
See more about comments here.
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What methods are you using to determine exposure and SBR, to establish a developing time, with conditions of backlighting?
I find this to be a troublesome situation.
Printable View
What methods are you using to determine exposure and SBR, to establish a developing time, with conditions of backlighting?
I find this to be a troublesome situation.
Meter using the incident method for the shadow area. Expose and develop normally. That's all there is to it.Quote:
Originally Posted by Claire Senft
[QUOTE=Claire Senft]What methods are you using to determine exposure and SBR, to establish a developing time, with conditions of backlighting?
When working, I used to do a lot of macro work with small sealed glass bottles or test tubes with bacterial or fungal cultures on their specific growth media.
I would meter with the incident hand-held meter pointing twards the polarized light source. Correct exposure was usually 1.5 stops (plus bellows extension, plus 1 and 1/3 for the on-lens polarizer) open from the light meter reading.
In about 20 years, I rarely found this technique to fail.
Thanks Ken, I'll try this out. I have always wondered a quantified manner in which to measure backlighting with an incident meter--before it was guesstimation (which was pretty close most of the time, but not all of the time).Quote:
Originally Posted by KenS
Claire, I use the incident method. For the low value I point the dome towards the camera, for the high value I point it towards the light source. I determine the high values by getting closer or further away from the light source. This is how I did the refractory shot. This BTW was a 37 minute shot and I measure the highlight at the frame of the window...I wanted the "glow" from it to be infectios. If I wanted the window more defined I would have gotten closer to the window so that it would have indicated a higher value and the corresponding lower development.....
Jorge, that is in line with what I am looking for. With backlight and the meter pointed in the direction the camera is facing, there is little difference betwenn the shielded and unshielded meter dome.
I rarely shield the dome...when I want more detail in the dark parts I just get the dome deeper in the shadows. Of course, when I cannot get close to the subjetc, shielding is the only option.Quote:
Originally Posted by Claire Senft
I thought the dome was the sheild!?Quote:
Originally Posted by Claire Senft
Could you explain this part to me?
This is something done mainly by those using the BTZS, to meter the "shadows" we sometimes shield the dome with our hand or gray card to simulate the shadows present on a scene.Quote:
Originally Posted by rogueish
I usually use some combination of incident and multiple spot reflective readings to determine exposure placement and the correponding development plan. The exact method depends, I think, on the subject and the nature of the backlighting, plus whether supplemental lighting (fill) is possible and/or desireable. "Backlighting" includes a lot of variable situations.
For example, a backlit portrait or model shot would be handled much differently than an image of a translucent object where the light transmitted through the object might determine its luminance value. With the former, I start with a spot reading of the face, and adjust that to place skin tone values; then incident-meter the back light to see what that's going to do with hair, etc. If the difference is too great, I might add a reflector or fill flash to bring up the light level on the subject. For the latter, a spot reflective metering of the translucent area, adjusted to place its tonality might be given precedence.


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Credits & Info
- Uploaded
- May 15, 2011 | 10:07 PM EDT
If you liked this, check these out!
Author Comments
Rated 5 / 5 stars
Good job
I like it, brothah!
Rated 3 / 5 stars
Not bad.
I like the use of filters, and the animation syncs with the sfx perfectly. The sound is pretty clean, but there is an annoying hum in the background. The lip sync was pretty good. Now you just need to work on dialogue and action a bit more.


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Tags: platinum coin
Return of the Coin?
February 17th, 2015
in Op Ed
The last few weeks have seen at least two posts calling attention to the potential use of the platinum coin in America's political economy. The first to appear was Rob Urie's piece in Counterpunch provocatively titled: more »
Krugman, Crazies and Platinum Coins
August 27th, 2013
in Op Ed, syndication
Paul Krugman had another shot at creating some mayhem in the economic and political blogosphere Monday. In a short column entitled "The Taper Versus the Crazy" the Princeton professor, Nobel Prize winner and widely read blogger discussed the upcoming de… more »
Framing Platinum Coin Seigniorage: Part Six, More Political/Economic Objections
February 13th, 2013
in Op Ed, syndication
This series provides a framing document for Platinum Coin Seigniorage (PCS). In the five previous parts of the series, I pointed out that there are three classes of opponents of High Value Platinum Coin Seigniorage (HVPCS, $30 T and above). The first… more »
A Coin for Reading
February 1st, 2013
in Op Ed, syndication
by J.D. Alt, New Economic Perspectivesp> In a recent essay I suggested that MMT might be applied incrementally to put people to work creating certain very special public goods. I suggested that the social norms which prevent people from "seeing" the… more »
Platinum Prescription to Overcome Austerity Disease
January 19th, 2013
in Op Ed, syndication
Make 'Em Do It! I Still Choose Using High Value Platinum Coin Seigniorage To End Austerity! Yesterday, Ezra Klein reported in the Washington Post that: The Treasury Department will not mint a trillion-dollar platinum coin to get around the d… more »


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Envisioning the world of 2100
View Single Post
September 14 2012, 02:17 PM
Yelp for People
Fleet Admiral
Location: Robert Maxwell's Profile
Re: Envisioning the world of 2100
Mars wrote:
Well we are talking about almost a century. Once we have machines that think like us, we will have passed the singularity point, the point at which machines can design improved models of themselves. Its about 88 years to the year 2100, a lot can happen in that time. I think the singularity will be reached before 2100, if we project 88 years into the past we get to the year 1924. How different was 1924 from today? Will the next 88 years have more changes in store than the previous 88 or less?
That is a
number of assumptions built into just one post. The Singularity probably won't happen due to a litany of reasons too long to list here. You're basically saying, "if the Singularity happens, then this problem will solve itself." That's pretty much my whole problem with Singularity advocacy. It's used to hand-wave what are actually very difficult problems.
No, I don't know how the future will look. Nor do any of us. In 1924, could anyone have imagined an extremely fast, global "telegraph" network with video screens and real-time cameras? Maybe, maybe not.
Something that these discussions of technology tend to overlook is, aside from what technology we can actually invent, how much of it ends up being practical and affordable for most people? The Internet would not be what it is today without the glut of (relatively) cheap computer hardware available to almost everyone in the developed world.
Likewise, let's make the leap that someone does create a generalized AI--but it requires a trillion dollars' worth of hardware and consumes a city's worth of electricity, and it makes decisions at a slower rate than a human. Is that ever going to be very broadly useful? I doubt it.
"Simulate everything" isn't a solution or even any kind of answer, it's a total handwave with so many assumptions behind it as to be meaningless. A bit like the Singularity, actually.
Five stars!
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COLUMBIA, S.C., Jan. 9 /PRNewswire-USNewswire/ -- Palmetto GBA, a leading provider of technical and administrative services for the federal government, has been selected by the federal Centers for Medicare & Medicaid Services (CMS) to process and pay all fee-for-service Medicare claims and perform related duties for South Carolina, North Carolina, Virginia and West Virginia.
After a full and open competitive process, CMS awarded Palmetto GBA a contract with a base period of one year and four one-year options to serve as the Medicare Administrative Contractor (MAC) for those states, known as MAC Jurisdiction 11. The contract has a potential value of approximately $300 million. As the MAC, Palmetto GBA will process and pay claims for both Parts A and B of the Medicare benefit program.
The contract also calls for Palmetto GBA to continue processing and paying Medicare claims from home health agencies and hospices in 16 states.
Nearly 600 full-time employees, most working from Palmetto GBA's headquarters in Columbia, S.C., will support the contract. All jobs are expected to be filled by current employees of Palmetto GBA, which under previous contracts processes all Medicare claims in South Carolina, as well as Part A claims in North Carolina and Part B claims in West Virginia.
Palmetto GBA will begin implementation activities immediately, conducting extensive outreach to health care providers, state medical associations and beneficiaries in Jurisdiction 11 to provide education and information about the transition. It will assume full responsibility for all fee-for-service claims in Jurisdiction 11 no later than March 2010.
Over the past three years, CMS selected 15 MACs nationwide to process claims for both Parts A and B of Medicare. The MACs are replacing fiscal intermediaries, which currently process Part A claims, and carriers, which currently process Part B claims. Medica
|SOURCE Palmetto GBA
Copyright©2009 PR Newswire.
All rights reserved


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::UPDATE:: We reached our safety goal. But don't stop now, we still have a ways to go. In order to finish the whole school year we need a total of $97k. So we need your help to keep going!
Keep spreading the word! More bucks = more days and more rides!
Transportation is the biggest problem facing Detroit today. And a lack of it hurts our children most of all.
Detroit is quite the big city. 140 square miles big. Despite that size, our population has shrunk to just under 700,000. Because of budget cuts, public bus service and school bus transportation is at an all-time low. It's never been harder to get around the city than it is right now. Stories like the one of James Robertson tell this tale in detail. But what you may not have heard is how kids and their parents are affected by Detroit's lack of transportation.
Enter The Youth Transit Alliance:
a little bus making a big difference.
But without funding, the buses stop end of day March 31st. Cold turkey. We can't let that happen and we need your help.
DOOR TO DOOR: The Youth Transit Alliance is a new kind of ride. Instead of picking up kids in bulk, we go door-to-door so the maximum number of kids can participate in quality programming regardless of the time. While a few kids do get bussing to and from school, nobody gets a bus ride to an afterschool program and the majority of kids don't get any sort of transportation. If these kids wanted to attend programs, many would have to walk past miles of factories and frequently in the dark. It's obvious that most kids simply elect to stay home when presented with that obstacle. Just a couple blocks can make all the difference between success and stagnation.
SUCCESS COMES FULL CIRCLE: If kids have a chance to attend programs regularly, it makes all the difference. Kids that do attend programs regularly have a much greater chance for success over kids that don't have access to quality programs. It's a proven fact. Kids are: Way more likely to graduate. Way more likely to go to college. Way more likely to bring that success back to their neighborhoods and further improve the city. The sky is literally the limit if we provide our kids with every chance we can. The YTA shows kids there's a world out there beyond the confines of their immediate vicinity.
ONE PERSON MAKES ALL THE DIFFERENCE: A conductor might just be one person but to a kid they can be the world. They're the caring adult on the bus who makes a bus ride into something special. The conductor focuses on the well-being of the kids which is something special. Having a solid adult that's there for them on time, every day further builds a support network around at-risk youth who deserve every possible advantage.
THEY CAN MAKE IT IF WE BELIEVE IN THEM: There are so many great programs available, but rarely do kids get to choose where they go. Now, a child can pursue their passion rather than accept only what's available to them. They can do all sorts of things from karate, to t-shirt design, to web design and way more. Plus, these programs teach crucial life skills that equip kids with the knowledge they need to succeed.
COMMUNITY MATTERS: While the YTA is a project of The Detroit Bus Company, we wouldn't get anywhere without robust support from the community. We've worked hard to build trust in the community including teachers, administrators, parents and the kids themselves. Youth voice is a powerful thing. This community involvement has led to a huge growth of users in our pilot neighborhood. The first child on a block using it leads to many more through word of mouth alone. The demand for equitable transit is there! It's up to us to provide it as a society.
But if we don't reach our funding goal, the buses stop end of day March 31st. Cold turkey. We can't let that happen and we need your help.
This service is the kind of thing that will help build our neighborhoods up from the foundation. The kids are the future of any city and their access to opportunity affects us all.
The hours after school are when kids are most vulnerable. Something as simple as a mentor or caring adult can make all the difference. In Southwest Detroit alone, The Skillman Foundation funds 40+ quality youth programs so that kids can be safe and continue learning long after the school bell rings. Parents even benefit because they are more productive at work and feel greater job security when their kids are safe after school. But still, distance is a huge problem and consistent attendance can be a challenge.
We took a look at the problem, smashed our brains together and came up with a solution we called The Youth Transit Alliance. Okay, so maybe it was a little harder than that, but you get the idea. The point is, we set out to empower more youth in Southwest Detroit to ignite their passions with their choice of after-school program, regardless of the distance.
The Youth Transit Alliance gives totally free rides to youth from their schools, to their after-school programs, then directly home to their door.
To start our service, we had to throw everything "known" about transit out the window. The old playbook simply doesn't work in Detroit. Unlike traditional transportation, the Youth Transit Alliance always goes door to door. With a driver and kid-facing conductor on board, kids are met with care, always accounted for and never left behind.
Once we had this awesome idea, we broadened the conversation so that everyone in the community could help shape this new concept. Southwest Detroit was chosen as our pilot neighborhood because the robust, vibrant community of people, organizations and leaders would help our tiny project grow big and strong. Almost two years on, the riders, parents and program leaders are key to the continued growth of YTA.
In our first year we managed to give 5,711 rides with just one 24-seater bus. We see this as a resounding success considering we were brand new to the scene. In Year Two, we honed a concept we call the "Take Home Area" to further increase efficiency and develop a replicable solution that we could apply to other neighborhoods. We've even gotten the attention of Detroit Public Schools and we're in talks to expand this service to other neighborhoods ASAP. That's a big deal.
Funding is always the problem. But we can fix it together.
Transit is expensive. Really expensive. Frequently, it costs more to get a child to the program than it does to provide the actual program to them. But we didn't let that stop us. Our budget for the 2014-2015 school year is $245,672.00. That's what's needed to run our program every school day for an entire year. Wowzerz, I know. The Skillman Foundation has kicked in $160,000 of that this year and it's up to us to raise the rest.
Our goal for this fundraiser is to raise $85,672. After Indiegogo and credit card fees, that becomes exactly $97,328.27 to keep the Youth Transit Alliance on the road until the end of the 2015 school year.
If we don't meet our goal, the buses stop rolling March 31st, 2015. Every dollar we raise keeps the buses moving a little longer and we'll keep you updated up at the top.
Solid funding is at the core of every project like this one. If we can figure that out, we can keep doing amazing things for transit in our city. Here's our breakdown for all of the costs involved in the project to the penny:
We're so close to success, but we need to finish this year. Our ridership numbers are growing every week and we are just starting to see the impact of our 'every door' outreach. As ridership continues to grow, we are testing the bounds of what one bus can do. If this fundraiser is a success, we can prove our model and work on implementing the Youth Transit Alliance in more communities across the City of Detroit.
Help us finish this year, get some great kids where they need to go and solidify our brand new model for a different kind youth transportation in Detroit. Your pledge could mean a world of difference for someone.
The Perks
The Detroit Bus Company L3C is a local not-just-for-profit company. It was launched in 2012 to help solve transit issues in the city of Detroit. The Youth Transit Alliance is a partnership between The Detroit Bus Company, The Skillman Foundation, Congress of Communities and Partnership for Youth. Our non-profit fiduciary is NEW.org.
Stretch Goals
If we're somehow lucky enough to achieve our funding goal, we don't want to stop there. Additional funding will allow us to keep rolling through the summer and provide transportation to a number of amazing summer programs. We've got a massive demand for summer transportation, but we can't make any promises without funding.
Stay tuned to this page and if we get close to our goal we'll build out our plans for the additional funding. Trust us, we can put it to good use.
Our Sponsors
We've been lucky enough to get some help along the way. It's important to recognize who helped us along our journey, whether it be big or small. Thank you for your tireless support, you're the reason we're still here today:
Watch the Videos
Here are some other great video pieces done on our project over the last couple years to help you get up to speed if you're just tuning in:
Dark Rye by Whole Foods
The TODAY Show (With Bob Dotson!)
Frequently Asked Questions
Why is the goal set for $20k instead of the actual $97k you need to raise?
I've got some additional questions. How can I reach y'all?
You can call us anytime at 313-444-2871 and you'll get a real, live human. You can also email us at email@example.com -- we're real good at the email. You can also visit us on Facebook.
What's the goal after this year?
Our big scary goal has always been to provide a safe ride for every child in Detroit. After-school programming is vitally important, but we also recognize that there are a huge number of kids who can't get to regular school every day because of a lack of safe transit. We're dreaming of a Detroit where every kid can get everywhere they want to go without a doubt. That's major, but it's what we need to do as a city to get back on the right track.
Why does transit cost so much? The public bus is like $2/ride.
The federal and state government subsidizes most public transit to the tune of 80-95% of cost, so that $2 bus ride actually cost $15-30 to provide to you. Since this is a brand new service, we've got to fund it entirely without governmental dollars. After a few years of operation, we can make the case to fold this into the public transit funding stream and make it more institutionalized.
Why are you all doing this?
We're Detroiters. We believe in this city and what its citizens are capable of doing if given a fair runway in which to launch from. Most of us were born here and we're going to be damned if we're going to watch it slide even further.
I'd love to donate something to your cause. How can I help?
Well, first and foremost, donating money goes the longest way towards acheiving our goals. We tried paying our biodiesel guy in goodwill but he just wasn't having it. If your company makes something you think our funders would like, reach out to us at email@example.com or call us at 313-444-2871. We'd love to have you aboard as a sponsor by supplying a great perk.
If you'd like to make a bigger donation or want to talk to someone about the project, feel free to reach out using the information above.


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Resolution: standard / high
Figure 6.
PDB 1FMT chain A domain assignments. a) Assignment by the CA algorithm as two domains, which matches exactly the correct split in the Benchmark_2 set. b) Incorrect assignment by DDomain, DomainParser2 and PDP. The extra incorrect domain is shown in green
Feldman BMC Bioinformatics 2012 13:286 doi:10.1186/1471-2105-13-286


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One-of-a-Kind 2014 BMW i8 to Hit Auction Block at Pebble Beach
Isn't Jeep planning on selling something very similar to this really soon???
@inline666 The new Renegade is loosely based on the 500L. I do not think it is meant to 'replace' it. I believe it is targeting a little bit different audience. Yes...slight demographic markets means a lesser degree of separation means similar but different models. 500L (which I don't think are selling well) are/were meant for the more youthful urban market. Ones that will not even see grass 70% of their lives year to year. The Renegade is designed to also be youthful but more of the active sports california type. Also keep in mind that 500L will also likely attract a more feminine buyer while the Renegade will be pretty distinctively male (but both with a decent equal spread). I am not sure if the 500L even offers AWD, but you know the Jeep will and with a likely TrailHawk edition, probably even include some (lighter than Cherokee) skid plates and the like).
This looks like a AWD 4X4 as it's a fiat panda they can use the AWD from that car


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For more information on heart disease, visit the American Heart Association.
SOURCES: Nadeem Sarwar, Ph.D., lecturer in cardiovascular epidemiology, University of Cambridge, England; Gregg C. Fonarow, M.D., professor, medicine, and director, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles; Byron Lee, M.D., assistant professor, cardiology, University of California, San Francisco; May 8, 2010, The Lancet
|Copyright©2010 ScoutNews,LLC.
All rights reserved


text: Mashup: College Toolkit Comments Share via FacebookShare via TwitterShare via LinkedinShare via Google+Share via RedditShare via Mail Map of Campus Hangouts near college campuses. Includes restaurants, bars, sports venues, museums, and more. Users can add their own listings as well. Track this Mashup Submit a mashup Summary Comments Followers Summary Comments Followers Comments (1) Comments(1) Comment * Leave this field blank Post Comment Jo (not verified) 3:18 PM Aug. 01 2006 reply College Toolkit is the best! When I was deciding on a school, the maps of the college hangouts gave me a great idea of the area around the campuses and the student life. I found it extremely helpful.


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Pokemon in fallout
Finally after months of putting it off I have completed my Pokemon mod for Fallout NV. For those of you who are familiar with my Fallout 3, its the same concept with few improvements. You throw you Pokeball to release your Pokemon, just like in the game. They follow you around as a companion would and fight along side you.
Download here www.newvegasnexus.com/downloads/file.php?id=40745


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The Journal Sentinel's team of Packers beat writers provide the latest news, notes and analysis
Post-game chatter: McCarthy and Rodgers speak
Philadelphia - Here are some excerpts from coach Mike McCarthy and quarterback Aaron Rodgers' post-game news conferences.
How confident were you in your defense on the last drive? "Oh, very confident. You know, we talked about it all week, just to keep them out of the end zone. They're a big-play offense and I thought Dom reall did a great job of sticking to the plan and with the coverage and presurre, in particular there in the red area, with the amount of pressure he was able to bring with the red zone blitz to keep them out of the end zone. They're an explosive offense and you hope you hold them under 20. We felt very good about that.
Did you encourage Rodgers to be patient? Absolutely. I mean, look who we're playing. We're playing in Philadelphia. It's a credit to their organization, just the crowd noise, the atmosphere. We did a very good job with communication, we didn't have the pre-snap penalties, didn't handkle the ball probably as well as we would have liked with the two turnovers. But our communication was excellent today. So we know we wer going to have to be patien, take what they give us. They played us pretty conservative from a pressure standpoint, third down was more of their pressure down.
Is this an important milestone for Rodgers winning his first playoff game? MIlestone? That's what you talk about. We don't look at it that way. I think you know that. Gosh, I just don't know why we have to talk about that today. We're just getting started. This is the first round, we've established ourselves as a football team. We won a big game here in Philadelphia vs. a championship caliber program. And we have the opportunity to go to Atlanta, so we're excited about playing the No. 1 seed down there. Aaron's got a lot of football left in front of him. He's going to be playing for a long time, and I think those conversations should be talked about at the end in my opinion.
On why he decided to go to RB James Starks as much as he did today? Well, it's hard, it's a juggling act. We have so much faith in Brandon Jackson. John Kuhn has done very well in packages. Dimitri Nance really hasn't had as much opportunity. He's given us a spark here and there. But you have James, everybody recognizes the talent, the ability and he has a chance to be a big-time player in our offense. But he just doesn't have the experience. I think everybody understands the schedule. It's hard to go back to training camp, OTAs and all the things that he missed due to his injury and to catch him up to speed Wednesday, Thursday and Friday. It's just a little different and we try to give packages each week and every opportunity he's been given, he's done a pretty good job.
How crucial was WR James Jones' drop? Well, in fairness to James, he clearly had the obvious opportunity right there before the half to put it to 21. But he has a thumb he's dealing with. So he'll fight through it. He's a warrior. He takes great care of his body, but he'll be the first one to tell you he needs to make that catch.
Did you expect such a contribution from the run game? No, I didn't to be honest. I thought I was going to have to play a good game and be efficient and do a good job on third downs, which we did. I thought that we were going to have a few more passing attempts, but the way that James was running, we just stuck with it.
Is Starks the running back you've been looking for all year? Ryan Grant is the back we have been missing all year, but James stepped up and did a nice job. You have to give John Kuhn, Brandon Jackson and Dimitri Nance some credit for running the ball this year. But coach has gone with the hot guy and the hot guy today was James, and he did a great job.
How did it feel to finally win your first playoff game? Well, in all my time being a football fan I have never seen one player win a game all by himself. It is a good team win for us and I will let you guys write what you want on that.
How important was the drive that ended in Jackson's 16-yard touchdown catch? That was one of th emost important drives of the game. The coach had a good call on third down there and you want to give some time to dial it across the middle. It was an important time of the game. The crowd was just getting into it and we needed to give our defense a break and make it a two-score game again.
How much of a challenge is it to face a short week going into Atlanta? Well, I think the greatest challenge is to see where we are at health-wise. Hopefully, we come out of this game pretty healthy. I think guys can handle the short week as long as we are feeling good and healthy. It is nice to know we are going to be back on the field in six days.
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Search thousands of Langley Park car dealers across the nation online at Autobytel.com. Find your prospective new or used vehicle by brand, year, price, or category. Autobytel has a huge directory of Langley Park car dealerships with their inventories of new and used car, truck, and SUV listings online. We will also guide you through the car buying process. View up-to-date values of automobiles, study vehicle stats, browse photos, research extensive analysis of the cars, and find prices pertaining to the Langley Park car dealership.
Times have changed and the need for visiting Langley Park car dealerships has been rendered obsolete. Thanks to the world wide web; Langley Park car dealers have the choice of having all of their stock of vehicles listed at various places like Autobytel.com. More and more consumers have turned to the internet to study-up on new cars. After a consumer has narrowed down their choices of new or used cars; they will begin to search the local listings of Langley Park car dealers. It will not be long till they come to an authorative car site like Autobytel.com. At our website you can get a free price quote from a number of Langley Park car dealers.
Putting faith in one Langley Park car dealership can represent a huge step. Do not presume that the only trip you will make to the Langley Park car dealer is to close the deal on a new or used car. There is a good chance that since Langley Park car dealers offer much more than new or used car sales; you will do business there again. Proper Langley Park car dealerships will have more than a car sales division; they will also have on the premises: a parts and accessories department, a service and repair center, a collision shop, and a finance and lease department. Since there is a very good likelihood that in the coming years you will revisit the Langley Park car dealer for repair or a replacement part. This is why growing a relationship with the Langley Park car dealership can have a lasting effect.
Find a reputable dealer by searching the Langley Park car dealerships database online at Autobytel.com See what previous customers of Langley Park car dealers had to say about their experiences. These appraisals of Langley Park car dealerships can be an effective way to figure out which dealership you should choose.


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NEW YORK, Oct. 15 /PRNewswire/ -- One Heartland will host "S'more to Love", a cocktail fundraiser on Friday, November 6, 2009 at 7:30 P.M. at Open House Lofts, NYC to benefit Birch Family Camp.
Celebrating its 20th year, the Birch Family Camp brings together 90 families (over 200 family members) from the 5 boroughs of NYC, along with 200 volunteers for a week of respite, therapy, and community building at a camp facility located in the Hudson Valley. Throughout the year this community helps each other connect to needed resources, shares medical information, and supports each other as they disclose their own HIV-status to other family members, including their own children. 100% of their clients are low-income and the program is free-of-charge. This is One Heartland's third summer of operating the program.
"New York continues to be an epicenter of the HIV/AIDS epidemic in the U.S. Even today, women and families continue to experience stigma, discrimination, and lack of coordinated services and care. There is still so much to be done in the fight to prevent HIV/AIDS in New York, and the Birch Family Camp program is an effective model addressing the complex issues families face," said Patrick Kindler, Director Program Services, One Heartland.
The fundraiser will include: a cocktail reception, special guests, dancing with DJ Stacey Stylez and great sponsors including SARAR (www.sarar.com), Ticketmaster (www.ticketmaster.com), Open House Lofts (www.openhouselofts.com), Paul Neuman Catering (www.caterernyc.com), CEG Management (www.ceg.com), For The Perfect Day! Events (www.fortheperfectday.com), Loft The World Productions (201.954.0834) and many
|SOURCE One Heartland
Copyright©2009 PR Newswire.
All rights reserved


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Despite the fervent, high profile effort to prevent New York's Twenty-Third District (NY-23) from electing Democrat Bill Owens their Congressman, the conservative upstate enclave has officially shifted from red to blue. That the effort failed is nothing short of an embarrassment for the conservative movement.
Along with 2012 presidential hopefuls, Sarah Palin and Tim Pawlenty, FreedomWorks Chairman Dick Armey fought hard to displace Republican candidate Dede Scozzafava. By clearing the way for Conservative candidate Doug Hoffman, they won the battle against their own party only to lose to their mutual opponent.
Armey, himself, lent his voice to a robo-call that rang the phones of "25,000 targeted households" in an attempt to get out the conservative vote. Armey and his "grassroots" organization are the same folks who rained on the libertarians' "tea parties" last April. FreedomWorks, bolstered by enthusiastic support from FOX News Channel, hijacked the anti-tax protests and perverted them into Obama-will-destroy-America hate fests.
Had Hoffman won the NY-23 seat, conservatives would have declared it a validation of their efforts to steer the GOP further right. With victory going to Bill Owens, the right wing of the Republican Party — many of whom no longer associate themselves with the GOP — will assign blame upon their centrists. Either way, they're marginalizing their moderates.
Progressive journalist David Corn summed it up hours before the polls closed in New York in less than 140 characters:
Good news if Hoffman wins in NY-23, GOP civil war will continue. Good news if Hoffman loses, GOP civil war will continue.
(more below the clip)
Frankly, I found it surprising that Hoffman came as close to winning as he did: 45 percent of the vote to Owens' 49. Armey, Palin, Pawlenty, and the campaign funds that came with them were outsiders. Hoffman, himself, didn't yet reside within the district he ran to represent.
The presence of Armey and his ilk exacerbated the perceived importance of this congressional contest. The spectacle of the GOP eating itself heightened the profile of the NY-23 special election among Tuesday's, already media-hyped contests. Considering those factors, I can't help but think that the residents of NY-23 resented the attention that tends to accompany Armey's traveling right-wing circus. That, at least in part, contributed to Owens' victory. Their objection to a moderate Republican candidate — Scozzafava, incidentally, still got 5 percent of the vote — helped turn a traditionally red congressional seat, blue.
See Also:
Jessica Pieklo, "The Conservative Canary in New York." Care2 Political Causes Blog, 2 November 2009.
Read more: bill owens, congress, conservative, dede scozzafava, democrat, dick armey, district 23, doug hoffman, election, freedomworks, new york, ny-23, politics, republican, right wing, sarah palin, tim pawlenty, voters
Image via flickr.com user - K3nna, via CreativeCommons.org
Dick Armey is leading an army of dicks.
America is spending your blood and your money in wars, such as the Afghanistan and the Iraq wars...
America is spent your blood and your money in wars, such as the Afghanistan and the Iraq wars...
Healthcare reform needs to be
1. eliminate the junk food industry, relocating jobs, reallocating the raw food, getting rid of junk food subsidies like ones for high fructose corn-syrup
2.Scaling back the meat industry drastically, reducing meat consumption, all that animal protein is driving people's bodies into the ground.
****3 Become a PLANT CENTERED Society, with everyone everywhere growing high quality organic plants for food and medicine.
"Let your food be your medicine" said Hippocrates****
4 Stop the senseless police brutality on your own citizens aswell as by military and private mercenary abroad. Pull out of all other countries. Reduce the military machine which has financially crippled the states.
5. sovereignty of your own money.
America is finished. Self-inflicted wounds and a rotten core. It's only a matter of time...
OK, an intelligent answer. Now, the non-profit running the public option should be instituted how without the help of the government? How can a brand new non-profit combat fraud better than the government can?
The government does not need to run the public option. It can be run more efficiently by a non profit organization that specializes in health care. Our federal government has enough problems with Medicare and Medicaid fraud (between $250 and $300 billion dollars a year) that they need to stop before they can convince me that they are capable of administering a public option plan that could just give the opportunity to multiply government run health care fraud if money isn't directed for fraud prevention and prosecution of the abusers in all government run health care programs.
Barack Obama wasn't "complaining" about Bush during the campaign, he was harnessing America's anger at the Bush administration's failed policies to get elected. It worked. If President Obama keeps reminding us of the horrors of the previous administration, it's because his critics have been whining about how he hasn't fixed the country yet, in less than a year.
Obama didn't just inherit "unfinished business and a deficit" as you put it, he inherited a deficit so monumental that it doubled our national debt in only 8 years. That's right, more spending than all the previous Presidents combined. He also inherited an economy on the verge of complete collapse (and like it or not, his methods have prevented that collapse), and not one, but two wars....... one which should have been finished years ago with Bin Laden either dead or in custody, and another one which never should have been foght in the first place.
You say you don't think the government should run the new public option, well then who should? Private corporations who take a full one third of your premiums as profit? Who?
To me the question here, is not around the politicians, it doesn't meter to me if they are Republicans, or Democrats! I'm not American and I don't lives in the USA. To me, the important is if they are making the right thing! And in watt concerns the Ambient and the Energy, they are making the good choices. If they are using the other's good ideas, they are in the right way!
Disclaimer: The views expressed above are solely those of the author and may
not reflect those of
Care2, Inc., its employees or advertisers.
Thank you
The Sheree Guthrie of this article has a baby and is pregnant again. She states, "They dont…
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Maine Red Claws v. Canton Charge
Head coach Alex Jensen of the Canton Charge discusses the next play... News PhotoBasketball - Sport,Canton - Ohio,Canton Charge,Discussion,Head Coach,Horizontal,Local Government Building,Maine Red Claws,Match - Sport,NBA Pro Basketball,Ohio,Sport,Sports Activity,USAPhotographer David Liam KyleCollection: National Basketball Association 2012 NBAECANTON, OH - NOVEMBER 23: Head coach Alex Jensen of the Canton Charge discusses the next play in the game against the Maine Red Claws at the Canton Memorial Civic Center on November 23, 2012 in Canton, Ohio. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and/or using this Photograph, user is consenting to the terms and conditions of the Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2012 NBAE (Photo by David Liam Kyle/NBAE via Getty Images)


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SoundCloud for Education
SoundCloud can help facilitate education in a number of ways whether you want to record or just distribute your audio.
Before You Start
Whether you want to distribute recordings of lectures, facilitate a way to receive audio amongst students or even communicate between student and teacher, SoundCloud can help. For example you can upload lectures to SoundCloud and push them to the relevant social networks, embed on sites and also submit to iTunes. With our record capability via the site you can even document lessons easily or even use it as a way to communicate.
Distribute Lessons and Lectures
Documenting lessons is a great way to both archive information and remove barriers for learning whether someone misses a class or is on the other side of the globe. Take University College London. They use SoundCloud to both communicate to students the latest news on UCL, and document and distribute their public lectures. They then embed that on their site and also distribute it via their social networks - predominantly Facebook and Twitter.
Want to transcribe your audio? Then try out Speaker Text who have integrated with SoundCloud.
There are endless possibilities when it comes to using SoundCloud for education! Get started today!
More info
- With our Record 101, you can learn how to use our site for recording.


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Former food service director facing charges
A former food service director in the Yough School District faces a preliminary hearing Monday on charges accusing her of stealing nearly $26,000 from the district.
Kristen Matey, 37, of 122 East Lane, Jacobs Creek, was charged with theft by unlawful taking or disposition, receiving stolen property, and theft by failure to make required disposition of funds received.
According to the affidavit of probable cause, Matey allegedly stole $25,959 in 2011 and 2012.
Matey's responsibilities included making bank deposits for cafeteria sales.
In March 2012, district Business Manager Michael Wrobleski noticed that Matey had been turning in late cash sheets needed to prepare accurate financial reports for the school board. Matey blamed the delay on her assistant, whom she said was having personal problems, according to the affidavit.
In August, a board member complained that a check submitted for the cafeteria two months prior had not yet been cashed.
Yough Superintendent Dr. Janet Sardon approached Nutrition Inc., which conducted an internal investigation and discovered some boxes of missing deposit slips and receipts that Matey was in charge of depositing into the district's account, according to the affidavit.
An audit contracted by the school district and Nutrition Inc. discovered $25,959 missing. According to the affidavit, Matey admitted she was stealing money from the district account "because she had encountered some unforeseen financial difficulties over the past year."
Sardon referred all calls for comment to district solicitor Gary Matta, who could not be reached for comment.
Chris Buckley is a staff writer for Trib Total Media. He can be reached at 724-684-2642 or email@example.com.
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Erectile dysfunction drugs vary in effectiveness, side effectsfor erectile dysfunction, but it also has a higherrate of side effects than other options, according to ananalysis of more than 150 trials.
Clinical trials may under report side effects of cancer drugspatients feel because physicians don't alwaysaccurately report side effects, suggests a new study.
Side effects vex anti-malaria push in Sierra LeoneMass drug distribution intended to reduce cases of the Ebola-like disease.
May Cause Drowsiness: Can Side Effects Be Eliminated? [Video] – The 64th Annual Lindau MeetingUnwanted reactions are an inevitable part of medicine—or are they? Nature Video examined this question during this summer's Lindau Nobel Laureate Meeting, which brought early-career biologists together with Nobel Prize–winners
No serious side effects in Merck/Newlink Ebola vaccine testand Canada's NewLink have had no serious side effects so far but a few experienced mild fever, researchers said on Tuesday.
Cutaneous side effects common with BRAF and MEK inhibitor treatmentpatients treated with BRAF inhibitors aloneor in combination with MEK inhibitors will experience cutaneoustoxic effects, researchers from Australia report.
Antipsychotic deflates the brainDrug for schizophrenia causes side effects by shrinking part of the brain.
Drug Ad Side Effects List Helps Sell ProductViewers of TV ads for medications interpret the listing of negative side effects as a sign of trustworthiness of the advertiser. Erika Beras reports.
Antidepressants have sexual side effects in teens, tooto make sure they understand that sexualside effects are common with the drugs, a new paper advises.
Some serious drug side effects not told to FDA within 15 daysBy Lisa Rapaport (Reuters Health) - Companies fail to report roughly one in10 serious and unexpected medication side effects to the U.S.
Side effects may lead breast cancer patients to skip endocrine therapyBy Kathryn Doyle (Reuters Health) - Breast cancer patients who report moreside effects
Gene-editing method tackles HIV in first clinical testEnzymes alter immune cells with no apparent side effects.
Problematic diabetes drugs may protect against Parkinson'sTwo problematic diabetes drugs associatedwith worrying side effects may reduce the risk
No advantage seen for intermittent vs. continuous ADT for prostate cancernot result in a lower long-termrisk of health-related side effects in older patients withmetastatic
Surviving Side EffectsSecurity fears spawn ways to treat radiotherapy's downside
Like Valium and Oxycontin, without the Side Effects [Video]Whether it be mental calm or analgesia, neuroscientists have discovered a range of possible health benefits from meditation
Rapid Excavationside effects and the evolution of excavating machines make tunneling increasingly attractive
"RxISK" Database Reports Side Effects, Including Violence, Undisclosed by Pharma FirmsMy previous post considered whether an antidepressant might have served as a catalyst for a gunman's massacre of 12 people at the Washington Navy Yard last week.
Drug that caused 'elephant man' side effect makes comeback after 2006 disasterAn experimental drug that causedappalling side effects in a clinical trial nine years ago isback
Lifting the Fog around Anesthesiageneration of safer targeted drugs without unwanted side effects


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Researchers found that 74 percent of patients who received an instruction sheet were compliant with their medication instructions on the day of surgery, versus 60 percent of patients in the control group. Patients were also less likely to stay in recovery after surgery for more than 90 minutes when an instruction sheet was administered. Interestingly, African-Americans, older adults (over 65) and patients with more than one chronic disease had lower medication compliance, the authors note.
"Physician anesthesiologists and nurse practitioners typically deliver a lot of verbal information to patients preoperatively, often exceeding patients' short-term memory," said Dr. Vetter. "Our findings show that providing patients with a standardized instruction sheet, both written and verbally, with simple language can improve compliance significantly. However, we speculate that a more concerted effort may be required to improve preoperative medication compliance in certain patients such as the geriatric population."
|Contact: Theresa Hill
American Society of Anesthesiologists


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Intellinote is a powerful platform for team communication and collaboration that puts your tasks, files, messages and online meetings...
Intellinote is a powerful platform for team communication and collaboration that puts your tasks, files, messages and online meetings...
The latest update to the cloud-based service reflects one of the more waggish Internet fads in recent memory than tools for fostering collaboration and productivity.
Tempo.ai, a productivity tool that bridges the worlds of collaboration and recommendation to help people work more effectively, joins the Salesforce suite.
Flow may not be the only new 'mobile first' lightweight productivity app Microsoft is building. There may be new, lightweight document collaboration and project management apps in the works, too.
Microsoft has bought another productivity company. This time it's LiveLoop, a vendor of collaboration plug-ins and tools for Microsoft Office.
Cortado's on-premise enterprise mobility management solution gets smart sharing, smart filing, native iOS printing, Sharepoint integration, fast enrollment and managed apps for Samsung Android devices.
Intellinote: Team Communication & CollaborationIntellinote puts your Tasks, Files, Notes & Real-Time Messages in one place, and is...
A S$42 million call-for-collaboration will target sector specific productivity issues and help SMBs leverage on economies of scale through collective adoption.
Many offices are turning to open designs. But to increase productivity that's not enough.
Varonis DatAnywhere enables you to access your files securely from anywhere while allowing IT to keep data safely stored where it is...
Can you do all of your office productivity, email and collaboration in the cloud? We examined the latest small-business suites from Google and Microsoft to find out.
Businesses must exploit open collaboration advances in procurement and finance to produce new types of productivity benefits, say an industry analyst and Ariba executive.
Appirio finds that collaboration and improved productivity are not really the top drivers for adopting social technologies in the workplace.
Redmond's cloud-based productivity suite aims to tap IT consumerization and digital natives joining the workplace and offer social, collaboration and mobile features for greater usability and traction.
Technology is supposed to simplify things and make us more productive, but sometimes the cost in time and money can erase any benefits.
case study Adopting mobile videoconferencing has helped raise productivity and collaboration for Mydin Mohamed Holdings, which runs retail chain in Malaysia.
Podio extends its productivity solutions to the granddaddy of collaboration platforms: Google Apps.
CIOs are starting to realize that the next wave of productivity will be outside their four walls. Welcome to inter-enterprise collaboration.
Microsoft has launched Office 365, its cloud-based suite of familiar tools, such as Office, SharePoint and Exchange, which it says gives smaller businesses the IT benefits afforded to enterprises
Google has enhanced the enterprise management capabilities for its Android smartphone platform, making it possible for administrators to secure and reset lost or stolen devices.In a blog post on Thursday, Google Enterprise Mobility product manager Mayur Kamat wrote that Android already worked "quite well" with the Google Apps productivity and collaboration suite, but the company was working to provide more functionality for those organisations using both platforms.
Although it's still early in the beta programme, Microsoft seems to be delivering the right mix of tools and features for an effective cloud-based productivity suite.
The beta programme for Microsoft's cloud-based productivity and collaboration suite is underway. Take a look at our gallery to see how it's shaping up.
The Cloud Connect plug-in lets people share offline Microsoft Office files with collaborators via Google Docs, without having to fire up the Google Docs web interface
Classic Steve Jobs disses you can put on your next resignation letter
Windows 10
With new Surface Book and Surface Pro 4, Microsoft aims high
Windows 10
Surface Book: Microsoft's first laptop, coming October 26 starting at $1,499
For privacy and security, change these iOS 9 settings immediately


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Dance Counts Community Meeting: Back Bay/South End/East Boston
Presented by Dance for World Community and Urbanity Dance
October 4, 2015
Your voice counts! In order to expand our collective understanding of dance in the Boston area, we need to hear from you. Come share your stories and make new connections as we discuss the dance scene in your community.
Hear from local dance leaders and share your perspective as we expand our understanding of the who, what, where, and why of dance in the Boston area. Four neighborhood meetings will ...more
Monsters Dance Convention Worchester
Presented by Monsters Dance Conventions at DCU Center, Worcester
November 20 - November 22, 2015
Monsters Dance will be returning to Worcester, MA on our 2015-2016 'Unleash the Beat' tour from November 20-22, 2015! Join us at the DCU Center ...more
National Theatre Live: John
Presented by ArtsEmerson: The World On Stage at Bright Family Screening Room, Boston
November 27 - November 29, 2015
DV8 Physical Theatre's new production, John, authentically depicts real-life stories, combining movement and spoken word to create an intense ...more
An Tua Nua with Metamovements
Presented by MetaMovements Salsa at An Tua Nua, Boston
Metamovements offers semi-private salsa lessons every Wednesday starting at 7 for those who want to quickly learn how to become better dancers. At ...more