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The Graduate Center offers more than thirty doctoral programs in the arts, humanities, social sciences, and natural sciences, including History.
Learn about the Graduate Center's core faculty,
including Distinguished Professor David Joselit (pictured),
on the Faculty Profiles page.
Through its extensive public programming, the Graduate Center contributes to the intellectual and cultural vitality of New York City.
The Graduate Center has announced its
Doctoral Student Parental Accommodation Policies.
Support for the Graduate Center ensures continued excellence in arts and
sciences graduate education, research, and public programming.
Because most courses are taught (and dissertations are supervised) by faculty whose appointments are at colleges other than The Graduate Center, CUNY's doctoral programs are dependent on the consortial cooperation of the colleges. The allocation system is the University's means of recognizing the contribution of college (i.e., non-Graduate Center) faculty to CUNY's doctoral programs. The system involves the annual allocation of funds to the CUNY colleges participating in the doctoral and master's programs at The Graduate Center.
In the allocation system, each doctoral course is considered a unit, and six units equal a line. Each enrollment in supervision of independent study and doctoral dissertations (90000) is credited as 0.2 of a unit, and thus five enrollments equal a course. The Graduate Center will credit each college with the units earned by faculty members supervising independent study and dissertations only if the college routinely recognizes as part of doctoral faculty workload the "courses" earned by these enrollments.
A graduate course earns a course credit in the allocation system for the home college of the instructor when five or more doctoral students enroll (excluding auditors). Partial credit is not given for courses with fewer than five doctoral students. A doctoral course (80000 level) with fewer than five enrollments will be canceled as not having met the minimum level of enrollment.
The Executive Officer must confirm arrangements for participation of college-based faculty by sending a letter each semester to the academic dean and the department chair of the appropriate CUNY college.
Updated 5 May 2015
Category: Academic Affairs


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Even after two difficult seasons and breaking the school record for losses, Austin Peay remains hopeful it can return immediately to its typical position near the top of the OVC.
The Govs will miss two valuable seniors, particularly forward Anthony Campbell, who scored 1,000 points in his career and finished second to Travis Betran on this year's team with 14.6 points per game. Govs coach Dave Loos said both made important contributions to the program by fighting through adversity on and off the court.
But Austin Peay also landed two players on the OVC All-Newcomer team, including their ...

subset: commoncrawl


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The nerdy part of me decided to sit down this past week and make a list of the frugal things I'd accomplished in the previous seven days.
During a nearly-impossible-to-execute Dual Naptime in which Littlest Roy (6 months) actually slept and Little Roy (4 years) tried to make me think she was sleeping even though the thumps and creaking doors upstairs indicated she clearly wasn't, I scrawled my list out on a sticky note - and even had to use the back side.
This is not to boast about anything I've done, because although you know me as the Bargain Advocate, I'm hardly perfect when it comes to matters of ...


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Jumbo Pumpkin Pecan Muffins Recipe
- 2-1/2 cups all-purpose flour
- 1/2 cup sugar
- 1/4 cup packed brown sugar
- 2 teaspoons pumpkin pie spice
- 1 teaspoon baking powder
- 1 teaspoon baking soda
- 1/2 teaspoon salt
- 2 eggs
- 1 cup canned pumpkin
- 1/2 cup buttermilk
- 1/4 cup canola oil
- 1 teaspoon vanilla extract
- 1/2 cup chopped pecans
- 1/3 cup packed brown sugar
- 1/3 cup finely chopped pecans
- 1/4 cup all-purpose flour
- 1/4 cup cold butter, cubed
- In a large bowl, combine the first seven ingredients. In another bowl, combine the eggs, pumpkin, buttermilk, oil and vanilla. Stir into dry ingredients just until moistened. Fold in pecans. Fill six greased or paper-lined jumbo muffin cups three-fourths full.
- In a small bowl, combine the brown sugar, pecans and flour; cut in butter until crumbly. Sprinkle over batter.
- Bake at 375° for 25-30 minutes or until a toothpick inserted near the center comes out clean. Cool for 5 minutes before removing from pan to a wire rack. Serve warm. Yield: 6 muffins.
Reviews for Jumbo Pumpkin Pecan Muffins
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"I liked the texture of these muffins and used my own mixture of cinnamon, ginger and nutmeg instead of pumpkin pie spice. Will add more next time for more flavor. I also liked that they were not overly sweet."
"After reading the reviews about "too bland", I noticed I was out of vanilla, but had almond and wow what a great taste...pecans, pumpkin and almond flavoring...good choice. thanks..."
"I have made these muffins multiple times. I don't have a jumbo muffin pan so I made them regular muffin size and added mini chocolate chips. So good!"
"Received rave reviews at home and the office! Very moist!"
"My husband and I thought the texture was off, too dense for us. They also lacked flavor in my opinion. Don't get me wrong, they did get eaten but just not what I expected."


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And the gubernatorial debate winner is ...
Debate winners for Indiana governor on Wednesday night: 1. Rupert Boneham. 2. John Gregg. 3. Mike Pence. Sorry, but Pence is just so lost to real life, it's scary.
Michael Metzger
Buck Creek
Don't believe Rep. Truitt will vote for schools
A recent letter to the editor praised state Rep. Randy Truitt for being willing to meet with and listen to teachers. He was also lauded for "standing up for education."
As a teacher for 34 years in Lafayette School Corp., I believe in studying Truitt's voting record, not what he is saying now on the campaign trail. Truitt has voted to cut public schools funding in West Lafayette schools by $446.51 per child, in Lafayette schools by $255 per child, and in Tippecanoe County schools by $150 per child. Instead of funding our public schools, he has voted repeatedly to divert tax money to vouchers and private schools. It doesn't help our schools that Truitt "stands up" for education when he comes back to the district or when he runs for election.
We need a representative who will vote for public education in the legislature. Because Truitt didn't and won't vote for our schools, I'll be voting for Rick Cornstuble, a man who has spent his whole life fighting for schools.
Donna Osborn
West Lafayette
No better leader to guide Indiana than Pence
In today's political discourse, where talking heads abound and relentlessly engage in self-promotion disguised as analysis, it is easy to forget that our free American elections remain a model for the rest of the world. Indeed, it is easy to forget that elections matter. For Indiana in 2012, after eight years of Gov. Mitch Daniels' leadership, this election marks the beginning of a transition that will define what kind of state we want to be in the decades ahead. I can think of no better leader to guide us than Mike Pence, the Republican nominee for governor.
Three words come to mind when I am asked to describe Mike: principled, sincere and decent. These are attributes in a leader that, when combined with vision, predict an ability to set an agenda, bring people together and get things done.
As part of his campaign, Mike has talked about building an even better Indiana. He has introduced his "Roadmap for Indiana," complete with a mission statement and six goals. Its central theme is "to make Indiana the state that works." Focused on private sector job growth, education, and the health and safety of Hoosiers, he outlines for every voter what to expect when we elect him as our 50th governor.
Indiana has been fortunate that for eight years we've seen unprecedented progress. Keeping that going will not be a simple undertaking, but I have known Pence for more than three decades, and he is deeply committed to his faith, family, state and country. He has prepared well for the job, and I encourage all Hoosiers to place their trust in him with their vote on Nov. 6.
Murray Clark, former
chairman, Indiana Republican Party
Scary course set by President Obama
In response to a recent editorial suggesting we all need to educate ourselves before we vote, I wanted the writer to know that I have been "studying" since before the 2008 election. The Rev. Jeremiah Wright, Bill Ayers, Van Jones, Valerie Jarrett, Hugo Chavez (who recently endorsed Barack Obama) and countless more of the president's closest friends and mentors, were enough to convince me I would not like the path President Obama had in mind for this great country of ours. All should learn Obama's beliefs on late-term abortion, gay marriage, the United Nations, redistribution of wealth and his skewed vision for America's future.
Having watched the president "transform" America these past four years has been truly painful. In studying further, this year I attended the documentary, "Obama's America - 2016". I walked out of the theater with a tremendous amount of fear for America and her people. The president's disdain for capitalism and the America I love is ever apparent in this movie. Obama's book, "Dreams from My Father," confirms that one of his closest mentors was Frank Marshall Davis, an avowed communist. I absolutely agree that we all need to educate ourselves before this election. It is by far the most important election I have ever voted in.
Unfortunately, lies have always been in the political theater. Do some research on Google about lies from each candidate. You will find Obama's "pinocchios" far outweigh Gov. Mitt Romney's. One doesn't have to study hard to see the direction the president wants for America. Now that my studies are finished, I realize praying is my only solace. After all, Chicago politics will be hard to overcome.
Linda Klaiber
Romney's Etch-a-Sketch, other stealth candidates
Romney is the Etch-a-Sketch master.
He calls himself "an extreme conservative," then acts like he's not (but the extreme right will demand it); insisted Ted Kennedy and Paul Ryan show their taxes, but he refuses; called for a two-state Israel/Palestine solution, now backs off that stance.
He disdained, but now embraces the 47 percent; loved Romneycare, but hates the similarly-designed Obamacare; says he now supports coverage for pre-existing conditions, but clearly just for a minority of citizens.
He has switched from embracing pro-science/pro-environment positions to denying science; said "coal kills," but now supports more digging; allowed women freedom to choose in Massachusetts, now supports extremist pro-life positions - likely no abortion in case of rape or incest or to save a mother's life.
Can you trust anything he says?
I can't.
Then there are the Indiana stealth candidates. Mike Pence is selling himself as a nice guy governor-wanna-be who cares about women (and men), but he will certainly implement extremist positions on women's health and contraception.
Richard Mourdock, as U.S. Senate candidate, beat Sen. Richard Lugar on a tea party no-compromise platform, but now wants to sell the larger public on his reasonableness to compromise. Don't believe it.
And Todd Rokita, our U.S. House incumbent, wants to defund public broadcasting (before Mitt said he did), purely because there isn't enough conservative bias, and would quietly kill social legislation that serves the poor and needy, to sustain tax breaks for the wealthy.
Can you trust anything these men say?
I can't.
Richard C. Nelson
West Lafayette


text: Egypt army ousts president, suspends constitution Share this story email Share this story «Previous 4 of 69 Photos Next » Read the story « » Mideast Egypt Egyptian army soldiers stand guard in Nasser City, Cairo, Egypt, Wednesday, July 3, 2013. Army troops backed by armor and including commandos have deployed across much of the Egyptian capital, near protest sites and at key facilities and major intersections. The deployment is part of a bid by the military to tighten its control of key institutions Wednesday, slapping a travel ban on embattled president Mohammed Morsi and top allies in preparation for an almost certain push to remove the Islamist president with the expiration of an afternoon deadline. (AP Photo/Hassan Ammar)


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23038EW33 Nachi Roller Bearing Japan 190x290x75 Extra Bearings
Price: $995.88
Code: Kit10600
Product Descriptions
Nachi Spherical Roller Bearing
Steel Cage
190mm x 290mm x 75mm
Made in Japan
23038EW33 Nachi Spherical Roller Bearings, Steel Cage, Made in Japan, the 23038EW33 inner diameter is 190mm, the 23038EW33 outer diameter is 290mm and the 23038EW33 width is 75mm.
Nachi Spherical Roller Bearings
Nachi Spherical Roller Bearings are particularly suitable for applications where misalignment can arise from error in mounting or from shaft deflection. NACHI Spherical Roller Bearings are manufactured in a number of design and material configurations depending on the type of application and size of the bearing. Nachi Spherical Bearings have two designs, regular spherical roller bearings and spherical roller thrust bearings.


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DLA Piper secures victory for Goodyear Dunlop Tires in product liability suit
DLA Piper has achieved a victory for Goodyear Dunlop Tires in a product liability suit claiming defective tyre components caused a highway motorcycle accident.
Georgia Court of Appeals rules franchisees can assert claims for relief under Georgia's tort statute for violating the FTC Franchise Rule weblink
The Georgia Court of Appeals recently upheld a judgment entered on a jury verdict against a franchisor for violating the FTC's Franchise Rule.
Corporate Insurance Trends 2014 — insurance update (Australia) weblink
Corporate Insurance Trends 2014 is a collection of articles highlighting some trends and key issues for financial lines insurers and their insureds in 2014.
DLA Piper's Ian Taylor appears on the Daily Record's 'Very Important Professionals' list
DLA Piper has announced that Baltimore partner Ian Taylor has been selected to The Daily Record's list of 'Very Important Professionals'.
DLA Piper hires Karl Dial to its litigation practice in Dallas
DLA Piper has announced that Karl Dial will join the firm's litigation practice as a partner in the Dallas office.
In K2 Investment, NY high court reverses itself, confirms well-established case law weblink
The New York Court of Appeals, in K2 Investment Group, LLC v American Guarantee & Liability Insurance Company, has vacated its own prior decision.
Legal Notebook: December 2013 weblink
DLA Piper's Legal Notebook for December 2013 presents recent cases, headline issues and new legislation.


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Indianapolis Colts safety Antoine Bethea makes his entrance at a fundraiser at Mo's-A Place for Steaks, to benefit the Leukemia and Lymphoma Society, Monday December 10, 2012. Joe Vitti / The Star
- Filed Under
Heard around the Indianapolis Colts' complex Monday:Bethea honored
Antoine Bethea, a defensive cornerstone on the field for the Colts, has been cited for his commitment off the field.
The veteran safety has been selected the team's Man of the Year. That places him in the running for the NFL's Walter Payton Man of the Year award, which will be announced prior to Super Bowl XLVIII. It recognizes a player's community service and leadership. ...


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Getty Images/iStockphoto
Penzenstadler to appear on Wisconsin Public Radio
I-Team reporter Nick Penzenstadler will discuss this story on Wisconsin Public Radio on Tuesday. Tune in at 4 p.m. on the radio or listen online at wpr.org.
About this report
This story is part of our ongoing "Deadly Doses" series, which examines the spread and impact of heroin across Wisconsin.
Sunday: Heroin death prosecutions have spiked in Wisconsin, but vary dramatically by county.
Monday: Will any of the legislative bills signed into law by Gov. Scott Walker deter heroin use?
Green Bay Police Chief Tom Molitor describes Wisconsin's new heroin and opiate laws as single stitches trying to close an open wound.
A few of the new anti-heroin laws may have a noticeable impact over the next couple of years. But other bills signed into law by Gov. Scott Walker in April might not.
RELATED: Heroin death prosecutions spike in Wisconsin
INTERACTIVE MAP: Wisconsin prosecutions for drug-related homicide
RELATED: Wisconsin a leader in prosecuting drug deaths
Wisconsin joins a group of states rushing to pass provisions to address prescription drug and heroin addiction. One public health expert in Washington, D.C., praises Wisconsin for taking a holistic approach. But he's also quick to point out that the flurry of new anti-heroin laws were not necessarily aimed at prevention.
"These initiatives are all important, but many of them are post-addiction, instead of mitigating the problem before it starts," said Rich Hamburg, deputy director of the Trust for America's Health, a nonprofit health organization in Washington, D.C.
Wisconsin's seven new laws came amid an alarming increase in overdoses and a push by the state's Department of Justice and State Rep. John Nygren, R-Marinette.
Nygren acknowledges none of the laws will act as a "silver bullet," but he calls them an important first step in the right direction. The legislation came in response to the rise in heroin deaths across Wisconsin. There were at least 206 heroin-related deaths in 2012 and 227 deaths in 2013.
While the state's Department of Justice said it could take months to evaluate the impact of the new laws, here's a ranking — from most effective to least effective — based on interviews for this report.
1. Additional training with Narcan
Wisconsin joins about a third of the country with some form of "rescue drug" laws aimed at giving access to the prescription drug naloxone to police and other responders. Previously, only trained paramedics or doctors could administer the drug. Potentially, hundreds of more responders will carry the life-saving drug.
A $15 dose of the opioid antagonist known as Narcan rapidly counteracts the effects of an overdose of heroin and other narcotics like Oxycodone.
In Oshkosh, Narcan has been administered 32 times this year by paramedics trained to administer it in a nasal spray, with an injection or with an intravenous line, said Chuck Hable, a lieutenant with the fire department.
"It's one of the most gratifying calls for us because someone is literally circling the drain and in a couple minutes they're awake talking to you," Hable said.
While paramedics have the training, Hable said smaller fire departments like nearby Omro-Rushford or Winneconne-Poygan will benefit most from expanded training, which is expected to be approved through the state's technical college system.
It could take around six months to get supplies and training for the new naloxone availability, officials said.
2. Immunity for 911 calls
In the case of an overdose, no matter if it's fatal, a friend that's also using heroin is now protected from prosecution if they call 911 or take the friend to a hospital.
Those fellow users risked facing a felony in the past if they called for emergency help. Prosecutors, however, will still be able to charge a friend if they are the dealer, said Amanda Folger, an assistant district attorney in Winnebago County.
"We'll still charge people with reckless homicide when people die and the dealers associated with the drug," Folger said.
Wisconsin became the 18th state to adopt the law aimed at helping friends who overdose. Experts say the law could take months or a year to take root before users understand they won't get in trouble for calling 911.
"Overall this new law is a positive step in the right direction," said Eric Toney, district attorney in Fond du Lac County. "This (heroin problem) will not be solved through legislation, arrests and prosecution alone."
3-4. Money for treatment programs
Two pieces of legislation are aimed at improving access to drug treatment programs statewide.
The first pumps $1.5 million into the Treatment Alternatives and Diversion program. The county-administered-program has proven effective in some instances in combating root problems with drug and alcohol abuse, Nygren said.
A second piece of legislation creates a regional pilot program aimed at opiate addiction in rural areas.
That law will provide counseling and medical or abstinence treatment. Persons in that recovery program would eventually move into county-based or private post-treatment rehab programs.
The funding for TAD will allow about 25 more counties to participate and the rural initiative will be up and running by January 2015, said Jennifer Malcore, a spokeswoman for Nygren. About 35 counties are currently in the program.
However, both of these new laws could take months to take root, and they don't act early in the addiction process, said Bill Swanson, a drug officer with the Marinette County Sheriff's Office.
"As a law enforcement officer I see these laws differently because rather than focusing on drug and alcohol counseling I think we need to get to the youth long before they get into this," Swanson said.
Three other laws were passed based on standardizing several common practices that may not have been applied statewide.
5. Drug disposal programs
Prescription drug take-back programs are popular at law enforcement agencies statewide and a new law encourages communities to broaden their use.
Officials seek to limit access to prescription pills since that is the most common gateway to heroin use. A study released May 28 by the Journal of the American Medical Association Psychiatry said 75 percent of heroin users were introduced to opiates through prescription drugs.
The law goes into effect in 2015 and allows for the Department of Justice to grant permits to groups aside from law enforcement to collect the pills at police headquarters.
"This will make it easier for pharmacies to start accepting the unused or unwanted medications," said Brad Dunlap, who leads the Lake Winnebago area metropolitan enforcement group. "You see many people who don't want to or can't get to a police department office. We're only collecting about two percent of the unwanted medication out there."
Dunlap said it could be years before the pharmacies are on board with the program since transferring the drugs to federal authorities for destruction can be difficult.
6. Swift and certain punishments
A new law is aimed at making sure anyone who violates probation or parole faces "swift and certain" punishment. The model is based on research that shows the swift nature of punishment is more important than the length of confinement to drug users and repeat offenders.
However, the practice is already commonplace statewide, said Christian Gossett, district attorney in Winnebago County.
"We address almost all of our cases within two days due to the custody rules imposed within 48 hours," Gossett said.
7. IDs required at pharmacies
People are now required to show an ID when picking up prescriptions classified as most likely to cause addictionat the pharmacy.
Again, this rule was widely already followed by major retailers throughout the state, said Hannah Zillmer, spokeswoman for the state's Department of Safety and Professional Services.
"Previously a photo ID wasn't required, but was common practice," Zillmer said.
— Nick Penzenstadler: 920-996-7226, or firstname.lastname@example.com; on Twitter @npenzenstadler


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High expression of the RNA-binding protein RBM3 has previously been found to be associated with good prognosis in breast cancer, ovarian cancer, malignant melanoma and colorectal cancer. The aim of this study was to examine the prognostic impact of immunohistochemical RBM3 expression in prostate cancer.
Immunohistochemical RBM3 expression was examined in a tissue microarray with malignant and benign prostatic specimens from 88 patients treated with radical prostatectomy for localized disease. While rarely expressed in benign prostate gland epithelium, RBM3 was found to be up-regulated in prostate intraepithelial neoplasia and present in various fractions and intensities in invasive prostate cancer. High nuclear RBM3 expression was significantly associated with a prolonged time to biochemical recurrence (BCR) (HR 0.56, 95% CI: 0.34-0.93, p = 0.024) and clinical progression (HR 0.09, 95% CI: 0.01-0.71, p = 0.021). These associations remained significant in multivariate analysis, adjusted for preoperative PSA level in blood, pathological Gleason score and presence or absence of extracapsular extension, seminal vesicle invasion and positive surgical margin (HR 0.41, 95% CI: 0.19-0.89, p = 0.024 for BCR and HR 0.06, 95% CI: 0.01-0.50, p = 0.009 for clinical progression).
Our results demonstrate that high nuclear expression of RBM3 in prostate cancer is associated with a prolonged time to disease progression and, thus, a potential biomarker of favourable prognosis. The value of RBM3 for prognostication, treatment stratification and follow-up of prostate cancer patients should be further validated in larger studies.
Keywords:RBM3; immunohistochemistry; prognosis; prostate cancer
Background and hypothesis
Prostate cancer is the leading cause of cancer death in men in economically developed countries [1] and there was an estimated 328 000 cases in Europe in 2008 which makes it the most common form of cancer in men [2]. For localized cancer, radical prostatectomy is the most common treatment and it has shown a benefit in cancer specific survival in comparison to watchful waiting [3]. Nevertheless, in some cases the cancer will recur with detectable prostate specific antigen (PSA) concentrations in blood, known as biochemical recurrence (BCR) [4]. Apart from PSA, no diagnostic or prognostic biomarkers have yet been incorporated into clinical protocols for management and risk stratification of prostate cancer patients despite extensive research efforts [5,6]. Thus, there is still a great need for new biomarkers to predict the course of the disease and differentiate indolent from life threatening cancer.
The RNA-binding motif protein 3, RBM3, is a glycine rich protein with an RNA recognition motif (RRM) capable of binding to both RNA and DNA and it is one of the earliest proteins synthesized in response to cold shock [7,8]. RBM3 is up-regulated in various types of human malignancies [9-11] and the role of RBM3 as a putative cancer biomarker was originally unravelled using an antibody-based discovery approach http://www.proteinatlas.org webcite[12-14]. Since then, RBM3 protein expression, in particular its nuclear localization, has been demonstrated to be associated with a significantly improved survival in several cancer forms, e.g. breast cancer [11], ovarian cancer [15], malignant melanoma [16] and colorectal cancer (Hjelm et al, Proteomics Clinical Applications, in press). In ovarian cancer, RBM3 has also been demonstrated to be an independent factor of good prognosis at the gene expression level [15] and in vitro data point towards a link between RBM3 and cisplatin sensitivity in ovarian cancer cells [15], possibly by regulating several cellular processes involved in maintenance of DNA integrity [17].
In this study, we investigated the prognostic impact of RBM3 expression in prostate cancer by immunohistochemical (IHC) analysis of benign and malignant specimens from 88 patients treated with radical prostatectomy.
Patients and methods
The patient cohort consists of 88 patients, between 48-74 years, treated with radical prostatectomy for localized prostate cancer at Skåne University Hospital, Malmö, from 1998 - 2003. Patient and tumour characteristics are shown in Additional File 1. Written consent was obtained from the patients and the local ethics committee at Lund University approved the study. Histopathological, clinical and follow-up data were obtained from the clinical- and pathology records. Vital status and cause of death was obtained from the Swedish Cause of Death Registry up until December 2006. The mean follow up period was 58.5 months after which three patients had died and 85 patients were alive. BCR was defined as PSA > 0.2 ng/ml [18] with a confirmatory level and clinical progression included BCR, death from prostate cancer and adjuvant radiation therapy. During follow up, 14 (15.9%) patients had BCR and 19 (21.6%) patients had clinical progression. Five (5.7%) patients received adjuvant radiotherapy and three (3.4%) patients received adjuvant hormonal therapy.
Additional file 1. Patient and tumour characteristics.
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For tissue microarray (TMA) construction, areas representing cancer and normal prostate tissue were marked on haematoxylin and eosin stained slides, whereby normal tissue was sampled in a noncancerous zone away from the tumour, in most cases the transition zone. Two 1.00 mm cores from areas with invasive cancer and one 1.00 mm core representing benign prostate tissue were sampled from each case and mounted in a new recipient block using a manual arraying device (MTA-1 Beecher Instruments Inc., Sun Prairie, WI, USA). For immunohistochemical analysis, 4 μm TMA-sections were automatically pre-treated using the PT Link system and then stained in an Autostainer Plus (DAKO; Glostrup, Copenhagen, Denmark) with the mouse monoclonal anti-RBM3 antibody AAb030038; Atlas Antibodies AB, Stockholm, Sweden, diluted 1:5000. The specificity of the antibody has been validated previously [15]. RBM3 staining was evaluated by two independent observers (LJ and KJ) who were blinded to clinical and outcome data. The fraction of cells expressing RBM3 in the nucleus (NF) were denoted a score from 0 (0-1%), 1 (2-25%), 2 (26-50%), 3 (51-75%) and 4 (> 75%) and the intensity (NI) was scored as 0 (negative), 1 (weak), 2 (moderate) and 3 (strong). A combined nuclear score (NS) of NF × NI, was then constructed as previously described [15]. Cytoplasmic staining intensity was graded as 0 (no staining), 1 (weak staining) and 2 (strong staining).
Statistical analysis
Spearman's rho and Chi-square tests were used for analysis of the correlation between RBM3 expression and relevant clinicopathological characteristics. Kaplan-Meier analysis and log rank test were used to illustrate differences in BCR free time and progression free survival (PFS) according to RBM3 expression. For survival analyses, RBM3 expression (intensity × fraction) was dichotomized into weak vs strong using classification and regression tree analysis (CRT). Cox regression proportional hazards modelling were used to estimate the impact of RBM3 expression on BCR (with RBM3 as a continuous variable) and PFS (with RBM3 as a dichotomized variable) in both uni- and multivariate analysis. All tests were two sided. A p-value of 0.05 was considered significant. All statistical analyses were performed using SPSS version 17 (SPSS Inc, Chicago, IL).
While absent or weakly expressed in benign prostatic glands (Figure 1A), RBM3 was clearly up-regulated in prostatic intraepithelial neoplasia (PIN) (Figure 1B) and in invasive carcinoma RBM3 was expressed in various fractions and intensities (Figure 1C-E) with 33 (37.5%) cases lacking RBM3 expression (Figure 2). A progression sequence with up-regulated RBM3 expression in PIN and retained high RBM3 expression in the invasive component is illustrated in Figure 3. There was no obvious heterogeneity in the staining pattern between duplicate tissue cores.
Figure 1. RBM3 expression in normal prostatic epithelium, prostatic intraepithelial neoplasia and in prostate cancer. Immunohistochemical images of RBM3 expression in (A) normal prostatic epithelium, (B) prostatic intraepithelial neoplasia and invasive prostate cancer, ranging from (C) high, (D) moderate, (E) weak to (F) negative expression.
Figure 2. RBM3 staining distribution in prostate cancer. Distribution of nuclear RBM3 staining in invasive prostate cancer, denoted as nuclear score (fraction × intensity).
Figure 3. Example of RBM3 up-regulation in prostate cancer progression. Immunohistochemical image depicting up-regulated RBM3 expression in (A) PIN and (B) adjacent invasive component with high RBM3 expression.
CRT analysis suggested an optimal cutoff point at NS > 2 to determine the impact of RBM3 expression on BCR free survival and PFS. While there was no association between RBM3 expression and conventional clinicopathological parameters (Additional File 2), Kaplan Meier analysis demonstrated that high expression of RBM3 was associated with a significantly prolonged time to BCR (p = 0.004) and clinical progression (p = 0.004) (Figure 4). These associations were confirmed in Cox univariate analysis (HR 0.56, 95% CI: 0.34-0.93, p = 0.024 for BCR and HR 0.09, 95% CI: 0.01-0.71, p = 0.021 for clinical progression) and remained significant in multivariate analysis, adjusted for preoperative PSA level, Gleason score and presence or absence of extracapsular extension, seminal vesicle invasion and positive surgical margins (HR 0.41, 95% CI: 0.19-0.89, p = 0.024 for BCR and HR 0.06, 95% CI: 0.01-0.50, p = 0.009 for clinical progression) (Table 1). These significant associations were retained in both univariate and multivariate analysis also when the few patients who received adjuvant radiotherapy or hormonal therapy were excluded from the analysis (data not shown). Cytoplasmic RBM3 expression was not prognostic (data not shown).
Additional file 2. Association between RBM3 and clinicopathological parameters.
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Figure 4. Prognostic value of RBM3 expression in prostate cancer. Kaplan Meier curves visualizing the impact of RBM3 expression on (A) biochemical recurrence free and (B) progression free survival.
Table 1. Cox univariate and multivariate analysis of biochemical recurrence free survival and progression free survival according to RBM3 expression
Interpretation and conclusions
Our results demonstrate that RBM3, while rarely expressed in normal prostatic gland epithelium, is up-regulated in PIN and invasive prostate cancer, and that patients with tumours expressing high nuclear levels of RMB3 have a significantly prolonged time to biochemical recurrence and clinical progression, also after adjustment for conventional prognostic factors. These findings are in line with previous findings in breast cancer [11], ovarian cancer [15], malignant melanoma [16] and colorectal cancer (Hjelm et al, Proteomics Clinical Applications, in press). Thus, there are increasing evidence for RBM3 being a biomarker of good prognosis in multiple cancer forms. The mechanisms behind these findings remain to be elucidated, an undertaking that might be somewhat challenging as current in vitro data point towards a proto-oncogenic role for RBM3 [8,9,19] and, hence, do not readily seem to support the clinical situation. However, the common hypothesis that oncogene activation is associated with an aggressive tumour phenotype does not always hold true, as well exemplified by the association between microsatellite instability and good prognosis in colorectal cancer [20]. It is evident that RBM3, while sparsely expressed in normal tissue, is up-regulated in most cancer forms and their pre-invasive stages in vivo. In light of the recently proposed association between RBM3 and DNA integrity in ovarian cancer [17], it could be speculated that RBM3 might play an important role in promoting early stages of tumourigenesis by interfering with the anti-cancer barrier provided by various DNA damage checkpoint mechanisms [21-23]. On the other hand, once a tumour has been established, an attenuated capability of DNA-damage response caused by RBM3 over expression might hinder the pressure for selection of more malignant clones [21,22]. Further studies are warranted to explore these associations.
In this study, we used a well-validated monoclonal antibody for detection of RBM3 expression [15,16]. Immunohistochemistry has several advantages compared to other assays in that it can easily be incorporated into clinical protocols and allows for assessment of the subcellular localization of proteins, which might have important prognostic implications. Our results indicate that immunohistochemical assessment of RBM3 expression in formalin-fixed paraffin embedded tumour samples could be a useful tool for prognostication and treatment stratification of prostate cancer patients. Since this was a small study these findings should be further validated in larger studies, preferably tumours from prospective, clinical trials.
List of abbreviations
BCR: biochemical recurrence; CRT: classification regression tree analysis; DNA: deoxyribonucleic acid; HR: hazard ratio; IHC: immunohistochemistry; NF: nuclear fraction; NI: nuclear intensity; NS: nuclear score; PIN: prostatic intraepithelial neoplasia; PSA: prostate specific antigen; RBM3: RNA-binding motif 3; RNA: ribonucleic acid; RRM: RNA recognition motif; TMA: tissue microarray.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
LJ carried out the immunohistochemical analysis, performed the statistical analysis, and drafted the manuscript. AG assisted with the statistical analysis and helped draft the manuscript. DU and AB collected the clinical data. AB also contributed with clinical input. MU participated in the conception and design of the study. KJ participated in the conception and design of the study, the immunohistochemical analysis and helped draft the manuscript. All authors read and approved the final manuscript.
This work was supported by grants from the Knut and Alice Wallenberg Foundation, the Swedish Cancer Society, Swedish Scientific Council, Gunnar Nilsson's Cancer Foundation, and the Research fund of Skåne University Hospital, Malmö.
We thank Elise Nilsson and Björn Nodin for excellent technical assistance.
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- Filed Under
Pundits had suggested the recently defeated referendum that could have dramatically changed the structure of local government would prove more popular among Muncie citizens than their counterparts in outlying areas of Delaware County.
As it turns out, those pundits - who theorized that rural residents, including farmers, would have concerns they might be asked to chip in on the cost of services now funded entirely by the city - were correct.
According to our calculations, 59 percent of voters living in precincts completely or partially within the city limits cast "no" votes against the referendum.
In non-city precincts, the percentage of "no" votes increased to 66 percent.
The overall margin of victory for those against the referendum was 62-38 percent. Under rules approved by current city and county officials, to have been adopted, the referendum would have had to receive "yes" votes from 66 percent of voters countywide.
Support for the referendum varied greatly among Muncie City Council districts.
In the two westside districts, 2 and 4, represented by Republicans Mark Conatser and Brad Polk, the vote was close, with "no" voters only slightly outnumbering those who supported the referendum.
But voters in two eastside districts turned out in great numbers with "no" votes. In District 6, represented by Democrat Julius Anderson, 70 percent of voters voted "no." District 1, represented by Democrat Doug Marshall, had a 67 percent "no" vote.
In districts 3 and 5 - represented by Democrats Mary Jo Barton and Jerry Dishman, respectively - about 60 percent of voters were against the referendum.
The Nov. 6 vote totals also show how dissident Democrat Kim Dowling scored what many considered an upset win over Republican Judge Alan Wilson.
In four eastside precincts - 12, 18, 19 and 20, taking in most of the Whitely and Industry neighborhoods - Dowling drew an amazing 88 percent of votes cast, building a 1,497-vote lead over Wilson.
Dowling's overall margin of victory was 1,468 votes. In the "other" 74 precincts, the judicial candidates ran almost dead-even, with Wilson drawing a combined 29 more votes than his successor.
Money doesn't always count - just sometimes
Just as campaign yard signs don't vote, a big campaign finance war chest doesn't guarantee victory.
Contrasting results from the Nov. 6 election with vote totals indicates that the big winner in fundraising, commissioner Todd Donati, didn't see much return for his $57,021 in contributions raised. The Democratic incumbent lost to Republican Sherry Riggin, who raised only $10,599 by comparison.
That "money doesn't buy happiness" vibe doesn't apply in every race. Democrat commissioner-elect James King raised $15,395 compared to $2,167 for unsuccessful opponent Steve Fields.
With $35,051 raised, attorney Kim Dowling had more than twice the total of the incumbent Delaware Circuit Court 2 Judge she unseated, Republican Alan Wilson, who raised $17,123.
The three top finishers for three Delaware County Council seats - Scott Alexander, Mike Jones and Kevin Nemyer - didn't exactly mirror the top three fundraisers. Republican Shawn Phillips raised more than most of the six candidates yet finished out of the running.
Candidate Fields forever
Because Muncie Democrat Kenneth Davenport is a candidate every election year - his failed bid for Delaware County treasurer in last May's primary marked his 15th run for public office since 1994 - it's easy to overlook others who have staged multiple campaigns of their own.
Take, for instance, Republican Steve Fields, who reached a milestone this year with his 10th campaign for public office.
He has certainly enjoyed considerably more success at the ballot box than Davenport, who has yet to win a primary race. Fields has been the GOP nominee for county clerk and commissioner, respectively, in the past two county elections.
He's also won three of his races: Two for Mount Pleasant Township trustee, in 2002 and 2006, and a Yorktown Town Council contest in 2011.
Fields began his political career with a run for a Muncie Community School Board seat in 1988. Since then, he's also campaigned for commissioner (twice, in 1992 and this year), auditor (1994), surveyor (1996), treasurer (2008) and clerk (2010).
He was also a candidate for GOP county chairman in 1993.
Fields entered the public eye more than a quarter-century ago as a younger colleague of a pair of colorful government critics, Richard Amburn and Basil Davis Sr., and he has continued to campaign on a theme of fiscal responsibility.


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- Darshay Davis
- Hometown
- Mirimar, Fla.
- School
- Everglades
Darshay Daviss TFRRS Profile (for top performances and meet results)
2013: Became the first Gator to qualify in back-to-back years for the NCAA Outdoor Championships in both the 100 and 200 meters since 20-time All-America Kisha Jett (1994-98) Two-time Honorable Mention All-American SEC Academic Honor Roll.
2012: Competed in 14 meets as a sophomore, seven both indoors and outdoors Finished third in both the 100 meters and 200 meters at the SEC Outdoor Championships, logging her personal best of 11.30 in the womens 100 meters at the SEC meet Ran 23.03 in the womens 200 meters at the Pepsi Florida Relays, registering a personal best in the event First Gator to qualify for the NCAA Outdoor Championships in both the 100 and 200 since 20-time All-American Kisha Jett (1994-98).
2011: Participated in 12 meets as a true freshman, including the SEC Indoor Championships, SEC Outdoor Championships and NCAA Outdoor Championships Had a collegiate-best 7.43 in the 60m at the Tyson Invitational Ran a career-best 11.53 (+1.0) in the 100m dash preliminary at the NCAA East Preliminary Round, finishing second in her heat Logged a career-best time of 23.59 (+1.2) in the preliminaries of the 200m dash at the 2011 NCAA Outdoor Championships.
HIGH SCHOOL/PREP: Competed at Everglades High School in Mirimar, Fla. Placed second at the 2010 FHSAA Class 4A State meet in both the 100 and 200 meter dashes Has recorded personal-best marks of 11.61 (100m), 24.03 (200m) and 55.9 (4x400m split). Was the Sun-Sentinels Broward girls track athlete of the year.
© 1998 - 2015 University Athletic Assoc., Inc., FOX Sports Sun & IMG College. All Rights Reserved.


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MythBusters: Collection 6 DVD
The MythBusters, Jamie and Adam, two special effects experts with over 30 years of experience, set out to methodically bust three urban legends in each episode. They test myths to prove or disprove what is real and what is truly urban legend. Includes 10 Episodes: Exploding Bumper, Swimming in Syrup, Car vs Rain, Seesaw Saga, Prison Escape, Curving Bullets, Thermite vs. Ice, Knock Your Socks Off, Duct Tape Hour and Bonus Episode: Viewer Special Threequel.
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- Format: DVD
- Rating: Not Rated
- Run Time: 430 Minutes
- Region: 1
- Aspect Ratio: Widescreen
- Studio: Discovery Channel
- DVD Release Date: September 21, 2010
- Genre: Documentary
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text: 24 Items View 12 / 24 / 48 Great product, could do better with instructions. By David on 11/21/2015 David would recommend this product to a friend Everything is high quality and wonderful. The instructions are generally clear, but require that you read them a few times. Just double check yourself, i almost read them wrong the first time. Did the trick, but it's far more than I needed By BBGoby on 3/9/2015 BBGoby would recommend this product to a friend I got everything up to where it needs to be this weekend, particularly the ALK, from about 4-9 over about an eight hour period, and Mg from 1200-1350. Calcium was OK. Having done this, I can now I can add Kalkwasser in my ATO in an attempt to keep ALK in range. So all good, but for my 32G it's far more than I need so I've got a lot of Starter package left over. Too bad they don't have a nano version, or the like. Great Starter Kit--improved with a Total Package Option By Stephen on 3/22/2014 Stephen would recommend this product to a friend Another hit from BRS! This package, coupled with the videos and other instructions, is a terriffic way into the world of Kalkwasser. One recommendation would be to offer a "total" package that includes the gallon jugs, the 1oz. dispensing pumps, and perhpas a 1 gallon mixing container. Secondly consider, placing the "You Will Also Need" segment from the printed instruction sheet under "Full Details." Great product By Jaime on 3/5/2014 Jaime would recommend this product to a friend I'm new to reefing. Bought this product based on the YouTube videos. After 3 weeks my tank looks much better. I currently have 1 frag of zoanthids and since I started dosing they look much healthier and have started to multiply. great kit By Jason on 9/1/2013 Jason would recommend this product to a friend this is a great kit and has everything to get your numbers up and keep them up. seems very pure and performs just as expected. Volume of Value By Jonathan on 2/20/2013 Jonathan would recommend this product to a friend Holy powder Batman!! Ton of Volume!!! Perfect Kit to get things going in the right direction. Follow instructions+ watch videos+ use calculator=perfection every time! Great value By Samuel on 1/3/2013 Samuel would recommend this product to a friend You really do get alot for what you pay for maybe to much(not a bad thing). The videos helped me out alot as I was new to dosing. Mixing each element was not as hard as I thought it would be either. This is an all around awesome package. After I got all my parameters where I wanted them I didn't think I would need the alk or cal solution but after a few water changes I noticed my cal jumped up but my alk didn't. I had to stop using kalk for a little bit til my cal went back down and dosed only the alk solution to keep it stable. This is an all around awesome package. Great Product! By Greg on 9/15/2012 Greg would recommend this product to a friend Great additives and at a great price as well. The sodium bicarbonate can be a pain to mix up, but it does it's job well. Great Starter By Shoei on 6/16/2012 Shoei would recommend this product to a friend Easy to understand directions and if you don't' they have videos on how to on here. Was packaged great no spills or damaged and its just a overall great starter product. Highly recommened for new reef tanks. Love this Starter Kit! By Jeff on 6/5/2012 Jeff would recommend this product to a friend I love how easy this kit makes dosing Kalc. I'm still a bit new to the hobby so anything that makes things simpler is great. Good Value, Excessive 2 part By Shooterrick on 5/20/2012 Shooterrick would recommend this product to a friend The product is a great value for the money. It is easy to use and my only critique is that there is a awful lot of 2 part Kh.CA, and Mg included for a starter kit. Luckily I find I like and will continue to use the product. Overall I would say buy it if you want to get into Kalk Dosing in a ATO. Great value By Jordan on 5/15/2012 Jordan would recommend this product to a friend i was pleased with the value and simplicity of the product. The BRS calculator and videos make use super simple Awesome By Adam on 5/8/2012 Adam would recommend this product to a friend This stuff is awesome. Started adding with my top off, have had massive growth with Lps and sps coral. Too Much! By Thomas on 3/29/2012 Thomas would recommend this product to a friend My only comment on this stuff is the sheer volume. I have been dosing the 2 part and Kalk for couple weeks and I have used very little of all the chemicals. Making a starter bundle w/ less volume may helped me determine what I needed and allowed me to buy fresh chemicals as needed. Although I am not positive I would assume there are some shelf life issues. Great kit By Carl on 2/21/2012 Carl would recommend this product to a friend I recently began dosing with these chemicals and have been quite pleased with the results. The calculator on the BRS website gave me good measurements to achieve the results I was looking for and has been working quite well since I began the dosing. The products have dissolved nicely in my RO/DI water which tells me the quality is very high and for the price its a great deal. great starter package By Matthew on 2/2/2012 Matthew would recommend this product to a friend This kit is awesome. Comes with everything I need for my dosing. And the kalk is perfect for my gravity fed slow drip ATO! Volume vs Mass By Matt on 1/31/2012 Matt would recommend this product to a friend Dry chemicals should be referred to in units of mass not volume. Really ?? You would like to dose 100 mL of dry CaOH?? Easy fix appreciated by people who like accurate label claims. A must By Brian on 1/2/2012 Brian would recommend this product to a friend Great package for a great price. Along with the videos and easy to follow instructions within this site, these sups get your reef tank where they need to be and aids in the stability of your tank. Truly a must buy. the only way to dose By Onborrowedtime85 on 11/22/2011 Onborrowedtime85 would recommend this product to a friend after watching a short how to video on BRS. dosing my tank just got easier and more reliable, isnt that what were all after... should come with bottles/pumps Best reef supplement! By Adam on 10/20/2011 Adam would recommend this product to a friend Kalk is the best! keeps the tank Calcium and Alkalinity stable, is easy to use with ATO and helps keep my low PH up! SPS Growth has rapidly accelerated Solid Preforming Kit By Charles on 7/23/2011 Charles would recommend this product to a friend the only reason i did not rate 5 stars is the kit does not contain magnesium cholride - only sulfate. magnesium mixing instrustions and video describe both so this is a bit confusing. outside of that it performs as described and when dosed in accordance with the calculator acheives the desired results. must buy By roger on 3/28/2011 roger would recommend this product to a friend Great value and just cant beat getting every thing u need for such low cost. i like that its shows pharmaceutical grade on your supplements so you know what your getting lota stuff for a little money By Prattusa on 1/7/2011 Prattusa would recommend this product to a friend I was very happy when I got this delivered. Now I can actually AFFORD my hobby (well, sorta!). I recently upgraded to a 210 gallon tank and man do I go through some chems or what?! These high quality chems as as good or better than the stuff you pay big bucks for in the stores and the BRS reff calculator is helpful. It would be nice if they printed some ratios on the products themselves, but it is not so hard to write that directly on the jugs once you mix it up. Good Buy By Andrew on 7/13/2010 Andrew would recommend this product to a friend a nice package of supplements Write Your Own Review You're reviewing: BRS Bulk Kalkwasser Starter Package *How do you rate this product? *Would you recommend this product to a friend? Yes No *Nickname *Summary of Your Review *Review Submit Review


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Whether a person's injury will lead to chronic pain may depend on the level of communication between 2 parts of his or her brain, says a HealthDay article based on a study published in the current issue of Nature Neuroscience.
For the study, the researchers used brain scans to examine the interaction between 2 parts of the brain—the frontal cortex and the nucleus accumbens—in 40 patients who had recent onset of back pain for the first time. The patients were followed for 1 year.
By analyzing the scans, the investigators were able to predict whether the patients would develop chronic pain with an 85% level of accuracy. Brain regions related to emotional and motivational behavior seem to communicate more in those who develop chronic pain.
Although the study showed an association between levels of communication in the brain and chronic pain, it did not prove a cause-and-effect relationship, the article says.
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December 1, 2015
NEW YORK (AP) -- Health officials say there's been an alarming increase in some dangerous superbugs at U.S. hospitals.
These superbugs are common germs that have become extremely resistant to treatment with antibiotics.
The number of hospitals reporting infections with these superbugs is still small. But a government report shows 1 in 25 hospitals saw at least one case last year.
The Centers for Disease Control and Prevention released the new tally Tuesday. They're urging hospital workers to take steps to keep the germs from spreading.
The dangerous germs can cause pneumonia and urinary tract and bloodstream infections in vulnerable, hospitalized patients.
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Hi, we are MagenTech!
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Detroit Red Wings left wing Jan Mursak (39) skates against the Carolina Hurricanes on March 24, 2012.
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The Detroit Red Wings placed little-used, oft-injured forward Jan Mursak on waivers Friday.
If he clears by noon Saturday, he can be sent to Grand Rapids.
"He needs to play," general manager Ken Holland told the Free Press. If that ends up being for another organization, the Wings can live with that outcome. Mursak has been eclipsed on the depth chart by the likes of Tomas Tatar and Joakim Andersson, both Griffins call-ups who've continued to be in the lineup when Mursak has been available. ...


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Things are moving far too fast in Kiev, Moscow and Crimea to write about events there. But the past isn't going anywhere. Though you wouldn't know that from the way the Obama administration talks about it.
Throughout this crisis - indeed, throughout all of Barack Obama's presidency - the White House has been eager to insist our long, unpleasant history with the Russians is behind us.
Obviously, every administration wants a fresh start with long-time rivals. That's why there have been four "resets" with the Russians since 1991, including George W. Bush's famous soul-searching gaze into ...


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Jill Kelley leaves her home Nov. 13 in Tampa, Fla. Kelley and her husband are claiming in a lawsuit that the government willfully leaked damaging information about them in the scandal that led to the resignation of Gen. David Petraeus as CIA director. (Chris O'Meara / AP)
WASHINGTON — The Tampa socialite whose complaints about cyber stalking exposed the affair that brought down David Petraeus filed a lawsuit Monday that accuses federal officials of violating her privacy.
Jill Kelley and her husband, Scott, filed the lawsuit in federal court in the District of Columbia seeking an apology and unspecified damages from what they say were willful leaks by federal officials of false and damaging information about them. Those officials should have been protecting them and their privacy, they say.
Instead we received highly hurtful and damaging publicity from willful leaks from high-level government officials that were false and defamatory, Jill Kelley said in a statement. In addition, we also learned that our personal emails were wrongfully searched, and improperly disclosed.
Jill Kelley had asked the FBI to investigate emails she found threatening. Those emails came from Paula Broadwell, who was the biographer of Petraeus, then the CIA director. The two had an extramarital affair that caused Petraeus to step down.
Also implicated in the scandal was John Allen, who as a Marine Corps general had been the No. 2 officer at Central Command in Tampa and who went on to be the top officer in Afghanistan. The Pentagon investigated Allen for potentially inappropriate emails with Kelley, who had hosted several parties at her Tampa home for military leaders.
Allen, Pentagon officials say, was exonerated by an inspector generals report that found no wrongdoing with the emails. However, the military has refused to release the 21-page report, which USA Today and other media outlets have requested, saying it would constitute an unwarranted invasion of personal privacy rights. Allen, who had been chosen to lead NATO, retired from the military after the matter became public.
Kelley, in a draft copy of her complaint obtained by USA Today, maintains that government officials, including FBI Director Robert Mueller, are to blame.
Defendants instead willfully and maliciously thrust the Kelleys into the maw of public scrutiny concerning one of the most widely reported sex scandals to rock the United States government, according to a draft copy of the complaint.
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text: Photos: Frigid fun starts New Year Share this story email Share this story «Previous 14 of 50 Photos Next » « » Polar Bear Dip A reveller takes the plunge during the annual New Year's polar bear dip in Herring Cove, N.S. on Tuesday, Jan.1, 2013. (AP Photo/The Canadian Press, Andrew Vaughan


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Edward G. Rendell
Americas public infrastructure our roads, bridges, airports, seaports, waterways, and even our sidewalks is a mess. You can see it for yourself every day. But its not just a nuisance, its bad for our economy.
Engineering experts estimate we need to invest more than $3.6 trillion now just to make our infrastructure competitive, not the best in the world, just acceptable.
Just how bad is it? U.S. infrastructure has fallen from first place in the World Economic Forums 2005 economic competitiveness ranking to 14th today. In almost every component of our physical infrastructure, we are stuck or losing ground every year.
China now boasts six of the worlds top 10 ports and none of the top 10 is located in the U.S. We now rank 19th in the world in port infrastructure, behind the likes of Iceland, Denmark and Estonia.
In air transport, were suffering from the worlds worst air-traffic congestion. Internationally, we now rank 32nd, behind countries like Panama and Malaysia.
While there are more than 15,000 miles of true high-speed rail in operation around the world, almost none are in the U.S., where we rank 18th in overall rail system quality, behind Finland and Malaysia.
Our roads are not much better. A third of all U.S. roads are in poor or mediocre condition. Since 1980, the number of miles traveled annually has essentially doubled, but the miles of new highway lanes have grown by only 4%. In 2010 alone, Americans wasted 4.8 billion hours sitting in traffic, wasting 1.9 billion gallons of fuel at a cost of $101 billion.
Nearly a quarter of Americas 600,000 bridges are classified as structurally deficient or functionally obsolete. Since 1966, 1,500 bridges have collapsed. As of the end of 2011, more than 1 in 10 bridges were closed or had weight limits that were too low to allow access to trucks.
When you add it all up, our nations capital needs for surface transportation alone exceed $1.7 trillion over the next 20 years. The longer we put off this spending, the higher the mountain we have to climb, and the further we risk slipping into second-rate economic status.
The time has come for the U.S. to commit to a long-term infrastructure revitalization plan that invests at least $200 billion a year. It should focus on transportation, but it should also include our water and wastewater systems, our dams and our electric grid. While 97% of the country has access to high-quality broadband, there remain some pockets of the country where private investment doesnt make economic sense, so we should be open to funding new broadband networks there, preferably through public-private partnerships.
We need a national infrastructure strategy that makes choices based on economics, not politics. We need a national infrastructure bank to finance large-scale projects and leverage private capital. When government dollars are involved, we need to promote accountability by setting clear criteria for all funding, and by carefully auditing the results to ensure projects are completed.
To ensure bipartisan support, we must avoid abuse and speed up the regulatory process. Recent investigations by federal inspectors general found wasteful use of economic stimulus funds to build duplicative broadband networks where good ones already existed. Thats the kind of waste that fuels cynicism and partisan division and delegitimizes needed government investment.
At a time when our nation is crying out for job creation, a smart and well-focused plan to meet our most critical needs can produce millions of good-paying American jobs over a sustained period of time. Most of all, we need to get to work on railroads, highways, and seaports or else we will watch time, and the international community, pass us by.
Former Pennsylvania Gov. Edward G. Rendell is a co-chairman of Building Americas Future, a coalition of elected officials focused on jump-starting U.S. investment in infrastructure.


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Total Members Voted: 191
Holy work! Is anybody else feeling swamped? How much time should this stuff be taking? What is a "normal" amount of time to study for a class?
Quote from: annarborbound on August 30, 2008, 09:41:49 PMHoly work! Is anybody else feeling swamped? How much time should this stuff be taking? What is a "normal" amount of time to study for a class?Don't worry about how much time you're spending on law school. I told myself that I wouldn't spend more than 4 hours a day outside of class. Other than for a few days before finals and when memos were due I was able to stick to that schedule. Obviously people have different study methods, I was probably the laziest summer starter but I can promise you that grades don't correlate with study time (based on the one grade we've received). I guess what I'm trying to say is don't get freaked out when people say they spend 10 hours studying a day. Just do what works for you, there are many paths to getting good grades.
Just a sidebar...how's the football team doing?Happy with your university's $2.5M investment in Rodriguez to buy out his K from WVU?Looks like it's paying off handsomely...
I was referring to your intellectual penis. Which is quite robust.
Jolie is creeping up on me.
Do any of you know what the girl who wrote Letters of Marquee is doing now? On her blog, she frequently repeats how she doesn't want to work at a law firm, but I can't imagine what else she's doing after SCOTUS.
What is Letters of Marquee? And could somebody offer a link to the blog? A quick google search wasn't terribly fruitful...


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It's been known for a long time that eating grapefruit and taking certain prescription oral medications - including the cholesterol drugs atorvastatin, lovastatin and simvastatin as well as some cancer and heart drugs - don't mix.
On Monday, the team of researchers who discovered the dangerous interactions nearly 20 years ago reported that the number of drugs that can cause serious reactions when mixed with grapefruit increased dramatically between 2008 and 2012, from 17 to 43, as new drugs have been introduced.
Writing in a review in the journal CMAJ, the scientists urged physicians who ...


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Buffalo, NY (SportsNetwork.com) - The Buffalo Sabres named Tim Murray general
manager on Thursday.
Murray takes over for Darcy Regier, who was fired in November along with head
coach Ron Rolston after a 4-15-1 start. Owner Terry Pegula brought in Pat
LaFontaine at the time to serve as president of hockey operations.
"I wanted to find the right fit for this organization," said LaFontaine at a
Thursday news conference.
Murray is the first full-time hire for LaFontaine, who named Ted Nolan interim
head coach in November. Since then, the Sabres are 8-11-3 and 12-26-4 overall
entering Thursday's action.
"I'm excited to be in Buffalo, where you strap on your boots, strap on your
skates and work hard," said Murray. "It's about detail. I see a lot of good
people in the organization. I think great things can happen here."
Murray had been the assistant general manager with the Ottawa Senators since
July 2007. Prior to that, he was the assistant director of player personnel
for the New York Rangers for two years when he was responsible for scouting
the amateur ranks and evaluating potential free agents.
His NHL experience began in 1993-94 when he served as an amateur scout with
the Detroit Red Wings. He joined the Florida Panthers in 1994, where his
scouting career evolved until his departure as the club's director of amateur
scouting in 2002. He then served as director of player personnel, responsible
for overseeing the amateur draft and college free agents, with the Anaheim
Ducks from 2002-03 to 2004-05.
Murray's uncle is Senators GM Bryan Murray.
In addition, the Sabres named NHL veteran Craig Patrick as special assistant
to the hockey department. Patrick was formerly a general manager with the
Pittsburgh Penguins and New York Rangers.
"I've had many rebuilds in my career, I was a GM for 23 years, rebuilt a lot
of teams, this is going to be fun," noted Patrick.
Patrick built a pair of Stanley Cup winners with the Penguins and was also GM
of the 2002 U.S. Olympic hockey team that won a silver medal at the Salt Lake
City Games.
The Sports Network


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Every year, especually in the summer, wildfires char land and threaten or destry property. They burn through forest, grasslands, and other areas. Learn more here.
The views expressed below are not those of Click On Detroit, WDIV, or its affiliated companies. By clicking on "Post," you acknowledge that you have read the Terms of Service and your comment is in compliance with such terms. Readers, please help keep this discussion respectful and on topic by flagging comments that are offensive or inappropriate (hover over the commenter's name and you'll see the flag option appear on right side of that line). And remember, respect goes both ways: Tolerance of others' opinions is important in a free discourse. If you're easily offended by strong opinions, you might skip reading comments entirely.


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A fire that heavily damaged a three-story home on the 3400 block of Wakefield Drive on Friday morning began with a basement couch.
Ozark Assistant Fire Chief Bill Arington says firefighters were called at 6:45 a.m. to reports of a couch on fire in the home's walkout basement. A person was reportedly in the basement when the fire began, and went upstairs to tell the other people in the house.
"By the time the occupant in the basement was upstairs and alerted everybody, the couch was fully involved," Arington said. ...


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In case his appearance at Sunday's game wasn't proof enough, Colts coach Chuck Pagano is in remission, his physicians say.
Pagano's oncologist said that a test of Pagano's bone marrow showed no sign of his disease, acute promyelocytic leukemia.
But that is not the same as being cured, and Pagano will receive two more rounds of chemotherapy, said Dr. Larry Cripe, an associate professor of medicine at the IU Health Simon Cancer Center. ...


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The days of being able to wait until you were close to retirement to transfer your GI Bill benefits are over, and Air Force officials want you to plan ahead so you and your family dont lose out.
Thats the message from personnel officials who sent a reminder Sept. 12 that transferring your post-9/11 GI Bill benefits to a dependent now requires a four-year service commitment.
The old reduced service commitment periods expired July 31, and now everyone who applies for transfer of benefits will incur a four-year active duty service commitment, said Bruce Houseman, education services and benefits chief at the Air Force Personnel Center, in a release.
The post-9/11 GI Bill pays up to 36 months of college tuition, housing and other fees. Eligible airmen can transfer all or part of the benefit, in monthly increments, to one or more family members.
Heres what you need to know:
The change
As of Aug. 1, airmen must have served at least six years and agree to serve four more years when they transfer their benefits. Before that, the Defense Department granted waivers to some retirement-eligible airmen that allowed them to transfer the benefit without the four-year commitment. The waivers were part of the startup of the Post-9/11 GI Bill in 2009 and applied to people retiring from the military between Aug. 1, 2009, and Aug. 1 of this year.
The four-year service obligations will begin on the date of the benefits transfer request. If dependents use the GI Bill but the additional service isnt completed, the service member could be forced to repay the government for any benefits that were used.
There are exceptions
Airmen who fail to complete the four years of additional service do not have to repay benefits used by dependents if they are released from the military for hardship, or for physical or mental conditions that did not result from willful misconduct, under Defense Department rules for the program. Those involuntarily separated by law or policy can have the four-year service requirement waived, provided they have at least 10 years of service on the date they transfer benefits and they agree to serve the maximum amount of time possible.
The rules
Transfers may be made to a spouse, child or a combination of spouse and children, but every family member who receives benefits must be enrolled in the Defense Enrollment Eligibility Reporting System.
A spouse may start to use transferred benefits if the airman has completed at least six years of service, but a child must wait until the member has completed 10 years of service. A childs marital status does not affect the receipt of benefits.
Make sure benefit gets used
Airmen may modify or revoke the transfer at any time under DoD policy. The key is to transfer at least some of the benefit as soon as possible to lock in the transfer and start the clock on the four-year commitment.
We suggest you transfer at least one month to each dependent, Houseman said.If you transfer all your benefits to one child and that child chooses to not use them for whatever reason you wont be able to transfer them to anyone else once you separate or retire from the Air Force. Your only option will be to retrieve your benefits and use them yourself, which you can always do later anyway.
Airmen have up to 15 years after retirement or separation to use the benefit to pay for their education.
Find out if you're eligible
In most cases, airmen can log in to the virtual military personnel flight to complete a statement of understanding at www.afpc.af.mil/shared/media/document/AFD-130912-017.pdf. Some enlisted members may be required to extend or re-enlist before they can sign the statement. Enlisted airmen do not have to wait until they are within 90 days of their date of separation to extend or re-enlist.
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Zuo Bilander Arm Chair Cushion$258.00
Euro Style Single Chaise Cushion$266.99
Zuo Cosmopolitan Sofa Cushions$278.00
Nautical Chaise Full Cushion$278.99
Waterfall Single Chaise Cushion$302.99
Product ID: CL-SB1-102
Custom cushion orders are custom-made specifically for your order. Therefore, it is imperative that the fabric selection, size of cushion, and quantity of cushions needed is absolutely correct at the time of order placement. Returns are not accepted unless cushions are incorrect or defective. If unsure about cushion selection options, please call customer service at for helpful, friendly advice.
In the garden or by the pool, Sunbrella gives you the stylish good looks you want and the all-weather protection you need. Available in a wide variety of rich colors, exquisite patterns, and supple textures that are equally pleasing to the hand and eye. At Wicker Central, we think Sunbrella is the perfect choice for long-lasting beauty and sophisticated style. Of course if there is a Sunbrella fabric you don't see, contact Customer Service to see if it is available.
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Within 30 days of your purchase, if you find your product online for a lower price, please forward documentation to our Customer Service. We take pride in our relationship with our brands and work with them to guarantee that you receive the finest quality products at the lowest possible price.
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This product ships FREE within 3-4 weeks
Most ordered items will ship via ground shipping by companies such as UPS or FedEx. If the item is excessively large (such as an 8' x 10' rug) or if there are many of the same item (such as six lamps), the items will ship via truck freight. If you have any questions concerning how your order will ship, please call us.
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This product ships FREE within 3-4 weeks
Caluco Cushions will ship to anywhere in the continental USA within two weeks of the order date. Please allow 5 - 7 days for ground transportation to your location. Orders are shipped from our warehouse in the Los Angeles area. Customers are provided tracking numbers so they can track their order. For expedited shipping please contact customer service.
You will be contacted approximately 24 hours prior to your actual order delivery via telephone by the shipping company. Once you have a delivery time determined, a truck will deliver your order curbside of your shipping address. It is your responsibility to bring the product into your home or area of choice and remove all packaging material and/or debris.
Many of the products we offer are customizable, with cushions that are made-to-order. As a result, some of the manufacturers we sell do not accept returns of these items (except in the case of incorrect or defective items).
For those manufacturers that accept NON DAMAGED returns, the following information applies. All returns must be in original packaging and be received in original, new and re-stockable condition in order to receive a refund less return shipping charges and a maximum 15% factory re-stocking fee if applicable. Please contact us at for details.
After we receive and inspect your return, we will refund the credit card used for the purchase less return shipping fees and factory re-stocking fees if applicable. We never keep your credit card information on file so you will receive a call from one of our Customer Service Experts to process your refund.
Return shipping charges and factory re-stocking fees are not refundable (except in the case of incorrect or defective items). Shipping charges and factory re-stocking fees will be deducted from the total refund amount. Due to shipping costs, we cannot offer any refunds or exchanges for orders delivered beyond the continental USA.
When your order arrives, be sure to inspect it to ensure that you received the correct products and that they were not damaged during transit. If you notice damages, be sure to note the damages with the delivery driver before you sign for it and contact our customer service department immediately. Although we experience very little concealed damages, we recommend (for large truck LTL deliveries) that you sign the delivery receipt notating "Pending Inspection". If you experience concealed damage, notating this for future reference will assist us with your claim process.
We know that sometimes it's not possible to notice all discrepancies before unpacking everything, long after the carrier has left. In such a case, please contact our Customer Service Experts within 14 Days of delivery and they will be happy to address the situation.
In all cases of damaged and incorrect shipments, we will gladly replace the item and the cost of shipping the item back to us for exchange.
After contacting us to process a return and get you a Return Merchandise Authorization (RMA) number, you will need to prepare your item for shipment. Please repack the item to be returned securely in the original packaging. Please write your RMA number in large characters on the outside of the box. Make sure the package is fully sealed before shipping. We are not responsible for packages that are lost or damaged.
Our Customer Service Experts will arrange to have the item picked up from your home. No need to take the item and have it shipped yourself; we'll take care of the legwork. Remember that return shipping charges and factory restocking fees (if applicable) are not refundable (except in the case of incorrect or defective items).
Caluco extends warranty coverage to the original retail purchaser that all cushions will be free from material and manufacturing defects for one (1) year from the date of purchase. Replacement fabrics may vary in color from the original due to dye lot differences. If within the warranty period identical materials are unavailable for repair or replacement, Caluco reserves the right to substitute materials of equal or better quality. Caluco will pay within one year from the date of purchase, shipping costs in the continental United States to repair or replace a defective cushion. Additional warranty coverage is available from Glen Raven Custom Fabrics, LLC for Sunbrella fabric constructed cushions. The warranty covers only normal usage. No warranty applies to any condition resulting from misuse or abuse, or any condition resulting from incorrect or inadequate maintenance, cleaning, or care.


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'It's once again an elite schedule,' coach John Calipari tweeted, 'but that's the standard here.'
Like its roster, the University of Kentucky basketball team's 2013-14 nonconference schedule is a doozy. The Wildcats, who will have at least eight McDonald's All Americans next season, will challenge themselves against four teams that finished in the top 20 in the RPI last season - and they'll get a shot at revenge for their season-ending loss in the National Invitation Tournament.
"It's once again an elite schedule," coach John Calipari tweeted, "but that's the standard here."
Although most of the marquee games - Michigan State in Chicago on Nov. 12, Baylor in Cowboys Stadium on Dec. 6, at ...


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2008 Honda Accord Coupe, Part Three
Why you should buy this car:
You've always bought Accords and the 2008 Honda Accord Coupe will merely be the latest. You don't know much about cars but you do know that you don't want to buy American. You fit the above criteria, but despite the physical onset of middle age you think you're too young for a four door.… »


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Officials say 221 names were listed during the first year of Ohio's registry for people convicted of arson-related offenses.
When Ohio joined the few states that require such offenders to register with authorities, officials hoped it would help solve more cases, deter repeat offenses and prevent deaths and property damage.
The usefulness of the registry, created last July, is difficult to evaluate. The Ohio Attorney General's Office runs the software that houses the database, but a spokeswoman said the agency doesn't track how often the registry is accessed or whether it has helped ...


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Colonial Gardens was built in 1902 across from Iroquois Park. Now closed, its future is starting to come into focus.
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Complying with a Louisville Metro Council directive, city economic-development officials on Monday began soliciting for developers to restore the landmark Colonial Gardens property across from the Iroquois Amphitheater.
The Metro Department of Economic Growth and Innovation issued a "request for proposals" for the long-shuttered property that the Metro Council recently approved for the city to purchase for $430,000. Developers have been given until July 31 to submit competitive responses for their proposed use of the site.
When the council recently approved the city's purchase ...