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One-stop shop for Bremen + Bremerhaven: two cities - one state.
Bremen Tourist Information (BTZ) and Bremerhaven Tourist Board operate jointly under the trade name < ALLES aus einer Hand > B2B sales, corporate packages and incentive programmes.
The aim is to promote the cities of Bremen and Bremerhaven as a travel destination and to improve the marketing of tourism projects.
B2B-Vertrieb for Bremen + Bremerhaven provides its customers with a one stop service - from the initial idea to the actual trip, from planning and staging a conference or congress to organising and running incentive tours.
A secure user area at www.bremen-bremerhaven.de provides all the relevant information, including a sales guide.
Advice and service
From your local travel industry/business partner via our customer advisors, stands at numerous trade fairs for both the travel industry and the general public, workshops and events.
All-inclusive packages
Inclusive breaks and packages tailored to meet individual customer needs.
Destination management
End-to-end liaison with service providers – one contact point for the complete trip, including best-price hotel rooms.
Operational service
Comprehensive information service with personalised tour description, route planning and maps.
Quality service
Constant monitoring of services and service providers, constant review of coach parking scheme.
Internet service
Own B2B site with sales guide, newsletter, press releases and picture download function.
Brochure service
Design and review of brochure pages, monitoring and updating of tenders.
Bremen Tourist Board
Production and distribution of tourism-related publications / brochures / electronic media etc. for the Bremen municipal area (hotel directory (D / EN / F), Bremen – At a glance, city centre map (D / EN) Media services: photo service for the media and promoters, tourism-related media activities and other media Visitor service: information and assistance in the Tourist Information offices, tickets sales for events, hotel reservations, conference and event management service, souvenir sales Promotional items and gift ideas: Bremen bill posters and large display pictures, general promotional items, audio/video material for travel agents.
Bremerhaven Tourist Board
Whether in the office, in our tourist information locations, or at fairs and exhibitions – the Bremerhaven Tourist Board is your professional and innovative partner in all matters concerning tourist offers, events and organisation in the Seaside City of Bremerhaven, who understands itself as an attentive and result orientated service provider.
Discover the sea in Bremerhaven with a fresh breeze and new ideas – the Bremerhaven Tourist Board and its dedicated team are there for you!
Travel arrangements for groups, companies and travel agents, individual tourists and families. From standard offers to customized itineries. Incentives, seminars and events – professional support from A to Z. Sailing trips and charters of ships for individuals and groups. Just call us – we will assist you!
Bremen, the beating heart of north-west Germany, has many different facets. Its history, tradition, high-tech achievements, scientific feats and innovation in space research make it an exciting and fascinating destination. Historic Bremen: nowhere is the city's vibrant heritage more remarkable than at its magnificent town hall (UNESCO World Heritage Site), the Schnoor quarter, Böttcherstrasse or the city's cathedral and the imposing statue of the mythological knight Roland. And, of course, there's the famous sculpture of the Bremen Town Musicians. Cultural Bremen: Bremen's theatres or the city's many museums, such as the Bremen Art Museum or the Weserburg Museum of Modern Art. Scientific Bremen: at 300 mostly interactive exhibits visitors can turn into explorers and at the Universum Science Centre discover technology, mankind and nature.
Welcome to the port city of Bremerhaven
Latitude 53° 33' North and longitude 8° 34' East. That's Bremerhaven in geographical terms. Today the skyline of the Havenwelten Bremerhaven with the Klimahaus, the Zoo am Meer, the German Emigration Centre and the German Maritime Museum characterise the cityscape. Modern exhibition concepts allow the present to be understood by exploring the past, with topics such as migration at the German Emigration Centre, climate change at the Klimahaus and modern treasure hunts at the German Maritime Museum. The covered pedestrian zone, the Columbus Centre and the Mediterraneo are the ideal place to enjoy a stroll and a spot of shopping. First-class fish restaurants, restaurant ships and shrimp fresh from the boat - all this can be experienced at the Schaufenster Fischereihafen.
Active & Recreational
A piece of Hawaii, a hint of oriental goodness, a touch of Far Eastern culture – it's happening in Bremen. Leisure activities don't come more appealing than at the Oase, Europe's largest health and spa complex located at Weserpark Shopping Centre. The splendid 15,000 sqm anti-stress environment delivers an oasis of peace and clam under a giant glass dome. Evocative of the warmth of a magnificent country estate, the Dorint Park Hotel Bremen in beautiful Bürgerpark uses the appeal of traditional hospitality, cutting edge conference technology and the award winning Spa'rks Wellness Center to pamper guests to the limit. Opening out onto communal parkland that gives a stunningly natural look to the landscape architecture, the hotel ensures the desire to calm the mind and leave behind the strains of everyday life.
Sail, Cycle and More in Bremerhaven
Located on the mouth to the North Sea, Bremerhaven, and the surrounding area, offers outdoor enthusiasts a variety of exciting water sports, like windsurfing, sailing, and waterskiing.
Those with a passion for cycling will enjoy biking to or from Bremerhaven along the beautiful North Sea Cycle Route and the River Weser Cycle Route. Numerous tourist packages are available especially for outdoor enthusiasts.
BTZ Convention Bureau – Your trusted partner
Backed up by a wealth of experience, the convention bureau of Bremer Touristik-Zentrale (BTZ) offers a one-stop service that will assist you in the successful planning and organisation of your conference, convention or other large-scale event.
Close cooperation with our partners, coupled with the personal dedication of our staff, ensure that your event is a complete success from start to finish. Let us help you plan your next event in Bremen.
BTZ Convention Bureau Conference and Event Management
Contact: Andrea Hess and team
Phone +49 421 30800-15/-16/-18/-19
Fax +49 421 3080089
Conference Center Bremerhaven – Meeting with a view!
Located in the midst of the "Harbor Worlds Bremerhaven", the Conference Center Bremerhaven offers an inviting Foyer, an elegant gallery on the 1st floor and is a unique location for receptions and get togethers – with a spectacular view of the River Weser.
Naturally the Conference Center Bremerhaven also has six attractive air-conditioned event rooms equipped with state-of-the-art congress technology for your conference, meeting or workshop. Through a passage you are directly connected to the ATLANTIC Hotel SAIL City.
For professional and individual support in arranging your special event please contact:
The Bremerhaven Tourist Board.
H.-H.-Meier-Strasse 6
27568 Bremerhaven
Phone +49 471 80936-148
Fax +49 471 80936-190
The Bremen experience is ideal for both large and small groups.
Does your group like a lively meal, a few drinks and a party, or is getting together for a cosy chat more your idea of fun? Are you interested in Bremen for its history, its maritime heritage or its entertainment? No problem: Bremen has something for everyone, whether on the river Weser, in the old town or "around and about".
City Break Bremen.
Take a guided tour of city-centre sights such as the town hall (UNESCO World Heritage), the Roland statue and the market square, plus Böttcherstrasse and the Schnoor quarter, then you have enough time left to explore more of Bremen on your own.
Price for two nights per person sharing a double room in a 3-star hotel from € 112.00 Net price incl. VAT.
For details and more packages please visit www.bremen-bremerhaven.de.
Bremerhaven: More to see and do and with a group it is even nicer
Maritime Ahoy
2-day package starting at € 93 per person (double occupancy)
Water, ships and the sea is what we have to offer. Enjoy the fresh air at the seaside and dive with the polar bears, whether above or under the water level - you'll surely enjoy the program.
Education Ahoy
2-day package starting at € 115 per person (double occupancy)
Bremerhaven offers a diversity of interesting attractions - go with us on a journey and emerge into worlds of climate, history, emigration and harbors.
Detailed information
For all listed packages and more interesting packages please visit www.bremerhaven-tourism.de
Barrier-free Bremen
A new service from Bremer Touristik-Zentrale gives tips and suggestions to help people with disabilities get the most out of Bremen. Among other things, it tells you which amenities and attractions are fully wheelchair-accessible, what facilities exist for people who are deaf or hard of hearing and what to do in an emergency. The list is growing and shows at a glance the restaurants, hotels, museums, theatres, cinemas and tourist attractions in Bremen that are disabled-friendly, including the town hall and the cathedral It also tells you where to find disabled toilets and more than 33 disabled parking spaces in Bremen and Bremen-Nord.
On request, Bremer Touristik-Zentrale will run special guided tours for blind people and also tours for deaf people in sign language.
Learn more on our fully accessible website: www.bremen-tourism.de
Vacation planning per click for the handicapped. A new offer for Bremerhaven and the North Sea region.Can I reach it with a wheelchair or will my baby carriage fit through? Are the offers in the museums also prepared for the blind? Is the guided tour also suitable for deaf or hearing impaired people? Our online-service offers assistance with these questions. All Information to the individual attractions can be found online under www.bremerhaven-tourism.de and also bundled under www.barrierefreie-nordsee.de. The data bank offers you the possibility to check everything before starting your trip. For example, which offers suitable for certain guest groups or which limitations one might find. You will learn: Passage widths, the availability of seating or acoustic floor position indicators.
City Packages for Bremen
Bremen Freimarkt
2-day package starting at € 89 per person (double occupancy)
October is when Bremen lets its hair down for the largest fairground in northern Germany. Now in its 980th year, the Freimarkt is a time for locals and visitors alike to enjoy good times, a friendly atmosphere and exciting attractions. The city is full of dancing and laughter for the opening event of the carnival season. Locally brewed Beck's beer is served in the festival tents and there are more fairground rides than at any other event in Germany. Don't miss this Bremen institution.
Package includes
For more interesting packages please visit www.bremen-tourism.de
City Packages for Bremerhaven
Departure to the New World 2-day package starting at € 70,50 per person (double occupancy)
Over 7 million people emigrated through the port of Bremerhaven. Follow the paths of the emigrants and explore the Seaside City with the most modern ship building industry and the longest river quay in the world.
Christoph Columbus 3-day package starting at € 113 per person (double occupancy)
Take a discovery tour through the various climate zones of the world and follow the paths of the emigrants, who started their uncertain journey to the New World from Bremerhaven.
For more information and interesting packages please visit www.bremerhaven-tourism.de
Bremen - the "Capital of Fair Trade"
Since 2011, Bremen has been a "Capital of Fair Trade". After participating in a nationwide competition Bremen outmatched 61 other municipalities and cities and was awarded the title "Capital of Fair Trade".
Green Sail in the Havenwelten Bremerhaven
Green SAIL is a programme of the ATLANTIC Hotel SAIL City, with which the Bremerhaven hotel firmly anchors its claim to sustainable operation in the corporate philosophy. Ecological, social, forward-looking!
With the Green Service, neither water nor chemicals are consumed in the room and, what is more, there is no carbon emission load. All guests who stay with us for more than one night are offered this service, and we are pleased when it is accepted as a valuable contribution for the environment.
As an added bonus, the guests can "fill up" with fresh air on the SAIL City panorama deck for free!
Bremen Space Tour
At Airbus Defence & Space visitors can watch parts being integrated into Ariane 5 rockets and the Automated Transfer Vehicle or ATV. Bremen Space tour is one of the guided tours run by Bremer Touristik-Zentrale (BTZ). It also shows how technicians on the ground stay in contact with their colleagues in the International Space Station.
Bremen Event Highlights
Bremen Music Festival: the crème de la crème of world artists, programmes that criss-cross repertoires and musical genres. Venues range from the traditional to the unexpected.
Christmas market: the historical market square is the perfect setting for Bremen's enchanting Christmas market. Visitors browse around the craft stalls and Christmas exhibitions in the town hall and in Böttcherstrasse.
For more information on all events please visit:
Bremerhaven Event Highlights
Bremerhaven Festival Week 2016
Seafaring right up close. The fleet meeting of special ships. The full range of seafaring, shipbuilding as well as regional handicrafts, customs and traditions. This is seafaring at the utmost. As a Seaside City with so many shipyards, and such diverse harbors Bremerhaven presents with the "specialists" the full range of shipping and shipbuilding. A presentation of regional handicrafts, customs and their traditions from the coast to the moor can be seen and there are many opportunities to have fun on land, at sea and in the air from May 26th . 29th, 2016. Ahoy!
For more information on all events please visit:
Two Towns. Together!
c/o Bremer Touristik Zentrale
Findorffstrasse 105
28215 Bremen
Phone Bremen: +49 (0)421 3080075
Phone Bremerhaven: +49 (0)471 80936130
Fax: +49 (0)421 3080025


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My son since birth never has been peaceful. At around 1 year old he would stand on his crib while sleeping fighting who knew what and crying and crying, I tried to calm him and soothe him. But that was always difficult. He would not see us, he would not know who we are. As he grew it kept going we slept with him most of our lives. TOday he is almost 19 years old , he told us for years mommy i cant' sleep because the people (demons) in my room don't let me sleep they scare me and they attack me. I thought it was his imagination. Now I start to believe my son has a big problem and I don't know how to help him. We are observant orthodox Jews. I want to seek help for my son but im not what to do . please help.
Thanks, Hanna

subset: commoncrawl


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What's Online!
Motor Live Drive
- Thursday 5-6pm
Local / Live Music
Live performances and interviews from WHFR's Studio J, featuring alternative and upcoming music artists, especially local, from all musical styles. Usually, a different artist or group for each hour.
Motor Live Drive Podcast
Motor Live Drive Podcast
- Login to post comments


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5 Ways Hollywood Tricks You Into Seeing Bad Movies
#4. The T&A Smash
According to science, nearly 50 percent of the world's population are huge fans of erections. If all else fails, producers can always try to draw in the audience with the promise of good ol' fashioned soft-core pornography.
King Arthur
Is the female lead leaving your film's posters a little, um, flat? No problem. They're lucky we live in an era where an 11-year-old can give Margaret Thatcher a dog's face (and even manipulate the picture too, hiyoo!).
Almost Famous
Cameron Crowe's comedy/drama about rock in the '70s was aimed squarely at middle-aged Americans who traded in their vinyl records for pleated khakis and a mortgage. Studio executives apparently didn't think Baby Boomer nostalgia would translate overseas, so they created an international poster that spoke the universal language of "jailbait."
Free-floating technophobia rarely spawns two hours of cohesive cinema, and this story of a computer-generated starlet is no exception. Fortunately, the poster promises plenty of boobies to make up for it!
In the actual film, Simone not only fails to appear clothing-impaired, but an aging Pacino remotely controls her every move. There's no better remedy for arousal then seeing Al Pacino attempt to mince seductively.


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Friday, November 2, 2012
Pecan Pie Brownies - Football Friday
These brownies are amazing. These are great for tailgating or even Thanksgiving dessert. How can you go wrong with pecan pie layered on top of gooey chocolate brownies? All this picture is missing is a big ol' scoop of vanilla ice cream!
This recipe uses a box of brownie mix for the base. I used Ghirardelli Double Chocolate Brownie Mix, and it worked great. These were a big hit at the tailgate. Shh, don't tell anyone, but I stashed a few brownies at home so we would have a few to snack on after the football game. It's one of the perks of being the baker!
Pecan Pie Brownies
(Printable Recipe)
1 package brownie mix and ingredients listed on the box (Ghirardelli Double Chocolate Brownie Mix)
1/4 cup melted butter
1/4 cup packed brown sugar
1 Tbsp flour
1/4 cup light corn syrup
1 teaspoon vanilla
2 eggs
2 cups pecans, chopped
Preheat oven to 350. Lightly grease a 9x9-inch pan.
Mix together brownies according to package directions. Spread in 9x9-inch pan.
Whisk together melted butter, brown sugar, flour, corn syrup, vanilla and eggs. Stir in chopped pecans.
Carefully spoon pecan pie mixture over uncooked brownies.
Bake 30-35 minutes. Cool and cut into 12 or 16 squares.
12 comments:
I'm not a dessert fan, but love brownies. This sounds incredible and a "must try".ReplyDelete
Oh yeah, nothing wrong with these.ReplyDelete
I made Bakerella's version a while back which puts all that in a pie shell. AMAZING STUFF! I used a Mocha Brownie mix that brought it up a notch! This sounds wonderful too!ReplyDelete
Never thought of pairing pecan pie with brownies - great idea!!ReplyDelete
I just finished making this. I couldn't find the Ghirardelli mix so I used Betty Crocker. Unfortunately after 35 minutes the top was overcooked and the brownie mix was undercooked. I'm not sure what I did wrong but I think it will still taste could over ice cream as a fudge/brownie/pecan topping.ReplyDelete
These are a 'must make' for my husband, he LOVES pecan pie and brownies AND ice cream.ReplyDelete
Made these tonight for my football night with friends, everyone loved them. One person wanted to know about your blog.ReplyDelete
Somehow I made these today without ever noticing the team logo on your plate; ironically we were watching the same game.
These are cooling in my kitchen right now. I hope they make it until Thursday!ReplyDelete
I had the same experience as Jennifer, top done and crisp on the edge but brownie doe looked like pudding! Tastes good, I did add coconut. HELPReplyDelete
If your top is getting too done, maybe try putting aluminum foil over it - we do that for pecan pies.ReplyDelete
I don't even like sweets but I just printed this out to make. Like, today.ReplyDelete


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Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
How Skin Tells Time
November 9, 2011|
The behavior of skin stem cells is regulated by a 24-hour circadian clock.
November 9, 2011|
The behavior of skin stem cells is regulated by a 24-hour circadian clock.
November 8, 2011|
A new study shows that over the past century, the age at which scientists produce their most valuable work is increasing.
November 8, 2011|
Elements 110, 111, and 112 on the periodic table are officially named.
November 7, 2011|
Researchers have developed a way to activate cancer fighting drugs by pulsing them with light, which could make such therapies safer.
November 7, 2011|
Women of the French families that colonized Canada in the 17th and 18th centuries had more children and grandchildren than late comers to the region.
November 4, 2011|
An alternative form of an enzyme involved in the glucose metabolism pathway protects cancer cells from oxidative stress.
November 2, 2011|
By selectively killing senescent cells, researchers can slow the decline of health in aging mice.
November 2, 2011|
Expecting significant cuts to the federal research budget, scientists are scratching expensive DNA sequencers off their wish lists.
November 1, 2011|
A snapshot of the most highly ranked articles in molecular biology and related areas, from Faculty of 1000
November 1, 2011|
With bids due last week, the city of New York City will now proceed to choose which university will get to build a high-tech research facility in the city.


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Meet and Communicate with Fun Singles Near You on BlackSingles.com
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Olympic mascots and their meanings
Published On: Jul 16 2012 10:04:46 AM CDT Updated On: Feb 12 2014 11:00:00 PM CST
With the 2016 Summer Olympics nearly here, look back at four decades of Olympic mascots and their meanings.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.


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30 Jun 2014 4:28 PM #1
Answered: List showing children of hasMany association
I have a hasMany association between RecipeModel and IngredientModel, named "ingredients".
User can choose a recipe and put it in the cart, and then customizes the recipe removing ingredients or adding them from a list.
As for now, there are 4 lists involved.
List A = list of available recipes
List B = list of choosen recipes
List C = list of available ingredients
List D = list of choosen ingredients
1. How could I automatically populate List D with ingredients of the selected (tapped or disclosed) record of List B?
2. How could I implement getRemovedRecords() and getNewRecords to get a list of ingredients added or removed from List D ?
In order to keep things simple I'm not posting any code, I'll do if anybody needs it to make things clearer.
I solved implementing a nested JSON hence using hierarchical store and models associations, thanks.
3 Jul 2014 4:53 PM #2
What does your models looks like?Get more personalized support via a support subscription.
Need more help with your app? Hire Sencha Services firstname.lastname@example.com
When posting code, please use BBCode's CODE tags.
Need to include a test case use:
The official Sencha Fiddle
10 Sep 2014 1:27 AM #3
I solved implementing a nested JSON hence using hierarchical store and models associations, thanks.


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25 Sep 2012 7:31 AM #1
Order in all-classes.js wrong on app build
Hi there,
I experience strange behavior with the app build. the compiled all-classes.js has a wrong order and puts a Ext.define before it creates the Ext object... This is happening in a more complex app where I migrated the skeleton from a generate app command... It is building fine in the skeleton itself...
PHP Code:
Ext.define("Ext.data.ResultSet", { loaded: true, count: 0, total: 0, success: false, constructor: function(a) { Ext.apply(this, a); this.totalRecords = this.total; if (a.count === undefined) { this.count = this.records.length } }});var Ext = Ext || {};Ext._startTime = new Date().getTime();
25 Sep 2012 10:37 AM #2
25 Sep 2012 1:10 PM #3
29 Sep 2012 12:52 PM #4
This should be fixed in the 184.108.40.206 build.Don Griffin
Director of Engineering - Frameworks (Ext JS / Sencha Touch)
Check the docs. Learn how to (properly) report a framework issue and a Sencha Cmd issue
"Use the source, Luke!"


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TOPEKA, Kan. (WIBW) - A flying museum landed in Topeka Thursday.
A Mitchell B25 bomber winged its way into Billard Airport. The vintage aircraft was made at the Fairfax plant in Kansas City, Kan. and is named "Maid in the Shade."
The aircraft flew 15 combat missions during World War II, mainly targeting railroads and railroad bridges in places like Italy and Yugoslavia. It even sports some repaired bullet holes from those missions.
While the plane brings back memories for veterans in its visits around the country, it also attracts attention from the next generation. Russ Gilmore, who pilots the plane, says he loves to see children at their visits so he can show them around and teach a bit about WWII history, which he believes doesn't get the attention it deserves in schools anymore. He says it's a way to honor the sacrifice veterans made.
The plane is at Billard through Monday, Oct. 1. It's free to walk around it. They suggest a $5 donation to sit inside. Flights also are available with prices starting at $395. Call 480-322-5503 to make reservations.
Money goes to maintenance and preservation and expenses for their travels. The plane visits about 75 cities during its summer tour.


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Air Pump, 12V, Rechargeable - Airhead
This convenient and versatile 12 volt air pump comes equipped with a 120 volt AC charger and a 12 volt charger that plugs into cigarette lighters. When charged, there are no cords to deal with. Equipped with 3 adapters to fit different valves. Will inflate or deflate continuously for 15 minutes on a charge. Peak air pressure is 0.64 psi and draws 11.3 amps.
Will this work while plugged in?
This is battery power only so the battery must be charged to operate.
This product ships in 1 business day.
Add to Cart and enter your Postal Code to determine the shipping charges and estimated delivery date.
Most products and orders leave our warehouse in 1 business day. However, select items may take more processing time. Alaska and Hawaii orders please add 1 additional warehouse processing day.
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Issue Date:
July, 2008
The July 2008 issue of Infotech & Telecom News features stories about the failure of municipal wi-fi networks across the country. On page 1 of this issue:
- In the most dramatic of the municipal wi-fi failures, the city of Provo, Utah has announced it will sell its money-losing iProvo municipal fiber network to a private firm.
- New Orleans has lost its muni wi-fi system as Earthlink decided to exit the sector altogether. City officials decided they would not take over the system.
- The Federal Communications Commission may spend $2 million in taxpayer funds on advertising related to the congressionally mandated switch from analog to digital television.
- The rule of piracy in the net neutrality debate roiled a recent U.S. House of Representatives subcommittee hearing.
Also in this issue: law enforcement use of cell phone data, media cross-ownership, online advertising, open access, net neutrality, computer chip wars, cable programming, and more.
Newspaper Articles in this Issue
No matching newspaper articles


text:
The Georgia Tech Library is a creative partner and essential force in the learning community and in the Institute's instructional, learning and research programs. The Library plans, develops and implements programs to provide expert staff, information, learning resources and information competencies to students, faculty, and staff and selected services to off-campus clients. Using appropriate technology, the Library delivers resources to satisfy information needs, promote lifelong learning and create productive connections for the scholarly community.
All materials in SMARTech are protected under U.S. Copyright Law and all rights are reserved. Such materials may be used, quoted or reproduced for educational purposes only with prior permission, provided proper attribution is given. Any redistribution, reproduction or use of the materials, in whole or in part, is prohibited without prior permission of the author.


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Probably a proof (if any exist) that calls upon Knuth's up-arrow notation or Busy Beaver.
The mathematician Harvey Friedman observed a special finite form of Kurskal's Tree Theorem. Regarding this form, Friedman discusses the existence of a rapidly growing function he calls $TREE(n)$.
The $TREE$ sequence begins $TREE(1)=1$ and $TREE(2)=3$, but $TREE(3)$ is a number so extremely large that its weak lower bound is $(A(...A(1)...))$, where the number of A's is $A(187196)$, and $A()$ is a version of Ackermann's function: $A(x) = 2↑↑...↑x$ with $x-1 ↑s$ (Knuth up-arrows).
Whereas Graham's Number is $A^{64}(4)$, the above mentioned lower bound is $A^{A(187196)}$. As you can imagine, the $TREE$ function keeps on growing rather quickly. For a discussion on the hierarchy of fast growing functions see here: http://en.wikipedia.org/wiki/Fast-growing_hierarchy
There are other examples of numbers greater than Graham's Number, as can be seen here: http://en.wikipedia.org/wiki/Goodstein_function#Sequence_length_as_a_function_of_the_starting_value, although I'm not sure if this number is larger than Friedman's $TREE(3)$
In one of Friedman's posts on the FOM mailing list, he mentions a number called SCG(13) that is far larger than TREE(3): http://www.cs.nyu.edu/pipermail/fom/2006-April/010362.html
I couldn't find a lot of other information about it, though.
TREE[3] is much larger than the numbers derived from Goodstein sequences for any reasonable input. See: http://www.cs.nyu.edu/pipermail/fom/2006-March/010279.html
The Goodstein function is upper bounded by ε₀, whereas the TREE function is lower bounded by the small Veblen ordinal.
BB(n) can surpass any recursive number, it is not computable. Perhaps, BB(1000) already inexpressible in any existing notation. You can also: BB(BB(n)), BB(BB(BB(...(BB(n))...)) (with "n" nested functions).
protected by Community♦ May 6 '14 at 9:18
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Because it has attracted low-quality or spam answers that had to be removed, posting an answer now requires 10 reputation on this site (the association bonus does not count).
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text:
Warren Circuit Judge Steve Wilson has dismissed Bowling Green Mayor Sandy Jones from an open records request lawsuit surrounding the Convention Center Controversy.
Al Baker filed the request to obtain copies of documents from Jones and the City government regarding conversations about the Convention Center.
Baker alleges a "plot or scheme" on behalf of the mayor to settle allegations against former Convention Center Board member Steve Catron. Catron is now being sued by the city to recover more than $700,000 in alleged overbilling and missing public money.
Baker's open records request comes after a war of words on the editorial page of the Daily News, and after a November 2003 newspaper article regarding the controversy.
Baker's attorney says his client believes the mayor was willing to let the Catron matter go without seeking reimbursement in exchange for Catron and his firm waiving several thousand dollars worth of outstanding legal bills owed by the city, charges Jones denies.
"That was not part of my discussion with either one of those firms that if they do this, they will or won't do anything else, just a matter of waiving the balances no one wanted to pay based on the controversy," Jones says.
"If you take out of context and craft your own story which is what the Daily News has done, you can come up with just about anything you want by cutting and pasting. But I have nothing to hide from decisions or my problem solving conversations for the city."
Jones says she elected to turn over personal emails from the fall of 2003 regarding the Catron matter, and City Attorney Gene Harmon released 10 additional internal emails to Baker. But Baker's attorney says there should be more.
"We're still looking at whether or not there are more documents. The tone of the documents very strongly suggests that there are going to be more, more documents to come," says Matt Baker, Al Baker's son and attorney.
One of the Emails released by Jones, dated October 23, 2003 includes this phrase: "If we can workout the 'amnesty' and 'start over' approach that we discussed yesterday about BKD, I would like to approach Steve about washing off the entire balance in 'good faith and community spirit.'" Jones says all of her Emails refer only to asking that the outstanding bills be waived, but says she never offered anything in return.


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1st Annual Total Cancer Care Summit: The Future of Personalized Medicine
Last Modified: March 30, 2007
Conference Dates: October 24, 2007
Conference Location: October 28, 2007
Sponsoring Group: H. Lee Moffitt Cancer Center & Research Institute and the University of South Florida College of Medicine
Conference Web Page URL: www.moffitt.org/continuinged/tcc
Topics Covered: Session topics include: Introduction to Personalized Medicine, Linking the Patient with the Data, Developing Genetic Signatures for Clinical Practice, Genetic Markers Predict Clinical Outcomes?, The Future of Personalized Medicine: Partnerships Between Academia and Industry, The Future of Personalized Medicine: Partnerships Between Academia and Industry, Role of Health Outcomes in Personalized Medicine, Revolutionizing Clinical Trials through Patient Matching, and The Future of Personalized Medicine: New Targets, New Imaging Technologies, New Trial Designs.
Conference Objectives: Define the benefits of personalized therapy for human cancers
Who Should Attend: This educational activity is planned to meet the educational needs of principal and clinical investigators, as well as clinical and surgical oncologists in both academia and industry Students specialized in cancer research and innovation are also encouraged to attend.
Conference Agenda: Please visit our website to view our most updated agenda and brochure at www.moffitt.org/continuinged/tcc
Registration Information: Please visit our website at www.moffitt.org/continuinged/tcc or contact Elizabeth Dackson at email@example.com
Conference Fees: $595 early bird before August 27/$625 regular
Continuing Education: Yes
Miscellany: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of South Florida College of Medicine and H. Lee Moffitt Cancer Center & Research Institute. The University of South Florida College of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of South Florida College of Medicine designates this educational activity for a maximum of 16 AMA PRA Category 1 CreditsTM.


text:
Foodsaver Mealsaver Compact Vacuum Sealing System White for $34.95
No need to throw away leftovers with the help of the convenient Foodsaver FSMSSY0214 vacuum-sealing system. Designed for use with the FoodSaver vacuum zipper bags and meal containers, the unit removes the air with the simple press of a button, creating an airtight seal that keeps pre-cooked meals, ready-to-eat foods, and frozen foods fresh for longer. The thoughtfully designed FSMSSY0214 comes with an easy-to-use retractable vacuum hose, and it delivers the same amount of power as a full-size FoodSaver appliance, but in a smaller, more compact size that takes up minimal space on the counter or in a drawer. Accessories include a bag holder, four meal containers, ten medium zipper bags, and five large zipper bags. The vacuum-sealing system measures approximately 9-1/4 by 8-1/4 by 2-1/2 inches and carries a one-year limited warranty


text:
I can't help you to author the advanced security guide for Ubuntu.
I do agree that I am going overboard with security again, but this is my nature and I am going to proceed.
I just modified my IP Tables using GUFW so I have all of the ports and protocols configured the way that I need them to work for my specific usage case. This should be the remaining steps that I need to take to harden and secure my Ubuntu 12.10 64 bit installation from the basic security guide. The next thing that I am going to work on is Novell AppArmor profiles on Friday afternoon. I plan to look at Bodhi Zazen's custom Novell AppArmor profiles along with yours and Rookcifer.
Expect a lot of questions and I need lots of help and support.
I know that my Ubuntu 12.10 64 bit installation is very secure right now. I am very safe from most attackers because well nobody is targeting me for an attack to my knowledge. I monitor my logs and my network traffic from my router to my Ubuntu.
Indulge me by continuing to post replies and suggestions. Expect me to continue my hardening process over the next two weeks.


text:
see all chemicals
Find a methodology
see all energy commodities
see all fertilizers
Free sample price report
To access your example ICIS price report:
1. Complete the form below.
2. Download your free price report based on the primary area of interest selected below.
3. A member of the ICIS team will contact you to discuss your information requirements.


text:
Some customer asked my if it was possible to restrict printing and editing a pdf file? Looking over Google I found this. I was wondering if is possible to encrypt a pdf file generated by word automation services (I really haven't checked out much sample code since I haven't installed SharePoint 2010 server yet -I have foundation on my dev machine-) Any suggestions would be greatly appreciated. Thanks in advance
Not out of the box. You would need to write your own PDF processor that accomplishes this either in an Event Receiver where the generated PDFs go. You could also create a custom action that you use instead of the word automation services to convert to PDF and accomplish this at the same time.
You are talking about Information Rights Management (IRM) which is supported in SharePoint 2010, though not very well for PDFs. If these were office documents, then the IRM would work as expected but PDFs generally open outside of the Microsoft ecosystem in either Adobe Acrobat or the Foxit Reader and to the best of my knowledge, neither of these work well with SharePoint 2010 IRM, though supposedly the Foxit Reader does do PDF IRM for SharePoint 2010 and for SharePoint 2013.
If the client is serious about restricting PDFs, you will likely need to look to a third-party solution or a codeplex one.
Typically, IRM makes assumptions about the environment in order for it to work properly and those assumptions are frequently too restrictive for the business.


text:
map 1
1A diagrammatic representation of an area of land or sea showing physical features, cities, roads, etc. a street map figurative expansion of the service sector is reshaping the map of employment
More example sentences
- The discovery of the city wall remains was not a surprise to the City Council as maps had pinpointed Peter Street as a location for the historic ruins.
- You have to identify a street with a name, using a map or a road sign.
- There have been no measures initiated nor a road map charted out, to rectify such fiscal imbalances and to restore balance for long term growth.
1.1A two-dimensional representation of the positions of stars or other astronomical objects.
Example sentences
- She reached in and pulled out a solar map, with one star highlighted.
- He looked at the star maps to see if there were any habitable planets or moons in the area.
- The Southern Fish is usually depicted on star maps at the feet of Aquarius, where it swallows up the water poured from his urn.
1.2A diagram or collection of data showing the spatial arrangement or distribution of something over an area: an electron density map
More example sentences
- The blue-colored image above shows some low-resolution electron density maps of the holoenzyme.
- The DLSM spatial maps of the fluctuation decay rates of the imaged cells confirm this finding.
- The radiolabelled object is then exposed to a photographic emulsion to obtain a map of radionuclide distribution.
1.3 Biology A representation of the sequence of genes on a chromosome or of bases in a DNA or RNA molecule.
Example sentences
- Generation of entire chromosomal maps has been a central problem in genetics right from its early years.
- The od gene on the Z chromosome of the classical map of the silkworm is located on group 3.
- Lines below the chromosomal map indicate the deleted region with the arrow pointing in the direction of the deletion.
1.4 Mathematics another term for mapping.
Example sentences
- This work gave an algebraic classification of maps from polyhedra to spheres.
- It is generally regarded as a study of the iteration of maps, of time evolution of differential equations, and of group actions on manifolds.
- Two algebraic varieties are said to be equivalent if there is a one-to-one correspondence between them with both the map and its inverse regular.
2 informal, dated A person's face.
Example sentences
- After an initial fit of entitlement, Ralph went and looked at his sister, his face a sorrowful map of genuine concern.
- He placed a claw against her lips, his face a map of exhaustion, but with a gentle smile.
verb (maps, mapping, mapped)[with object]
1Represent (an area) on a map; make a map of: inaccessible parts will be mapped from the air
More example sentences
- Has he seen the extent of the flood plain in a one in a 100-year flood in this area, as mapped by the Environment Agency?
- This system maps an area, showing where objects, that might be mines, are.
- The act gives ramblers the right to walk freely across mapped areas of open country, including mountains, moors and registered common land.
chart, plot, delineate, draw, depict, portray
1.1Record in detail the spatial distribution of (something): the project to map the human genome
More example sentences
- To achieve this goal we map the spatial distribution of volcanic seismic facies units.
- One of the promises of the human genome project which identified and mapped the genes on our chromosomes was that it could help to target medications better.
- Or, mapping the human genome could be judged as the greatest advance in the history of our species since we stood up on two legs.
1.2Associate (a group of elements or qualities) with an equivalent group, according to a particular formula or model: the transformational rules map deep structures into surface structures
More example sentences
- In particular, the k coloring problem can be mapped directly onto a model of a magnetic system in solid-state physics.
- We reported on this issue in our first investigative piece, when we found that the behavior maps to a specific position of the view camera.
- It would be possible to work through the classification describing how each kind of loop maps into different spatial and temporal orderings.
1.3 Mathematics Associate each element of (a set) with an element of another set.
Example sentences
- These latent variables are essential for linkage mapping and association mapping.
1.4 [no object] Be associated or linked to something: it is not obvious that the subprocesses of language will map onto individual brain areas
More example sentences
- For instance, if lattice dimensions are N x, N y, N z and N t and the dimensions of the machine are n x, n y, n z and n t, then the number of lattice points mapped on to a node will be N x/n x * N y/n y * N z/n z * N t/n t.
- Although Riemann had given a proof of the theorem that any simply connected region of the plane can be mapped conformally onto a disc, his proof involved using the Dirichlet problem.
- Cantor showed in 1878 that the unit interval I can be mapped bijectively onto the unit square I 2.
off the map
- (Of a place) very distant or remote: just a hick town, right off the mapMore example sentences
- Sakhalin is off the map, a fleck on the flank of Asia.
- The filmmaker sought to examine the mental stress experienced by the population in a place off the map or at the world's end.
put something on the map
- Bring something to prominence: the exhibition put Cubism on the mapMore example sentences
- I want to put the city back on the map and bring people from other parts of the country and see something different here.
- We're disappointed not to get through but it puts our club on the map again.
- I want to put this club on the map and, hopefully, turn Molesey into a footballing name.
wipe something off the map
- Obliterate something totally.Example sentences
- The US already has enough firepower to wipe a nation off the map and kill millions upon millions of people.
- He exterminates his enemies and wipes whole tribes off the map.
- More than a few times I shouted angrily and cursed the opposition as they came flying down with superior aerial units to wipe my units off the map near the 30-second mark.
Phrasal verbs
map something out
- Plan a route or course of action in detail: I mapped out a route over familiar country near homeMore example sentences
outline, set out, lay out, sketch out, trace out, rough out, block out, delineate, detail, draw up, formulate, work out, frame, draft, plan, plot out, arrange, design, program
- Previously, the dirt and turf courses were mapped out in detail while receiving devices were installed that would track the transmitter.
- Then a route was mapped out to take in as many different species and articles of interest as possible.
- If we uncover the road, we will have to map it out and give the details to the county archaeologist.
mapless adjective
- Example sentences
- This appears to be the mapless voyage of the Conservative Party, now wondering if they should boldly go to that land into which they said they would never stray - namely Europe and the euro.
- Having started early so we wouldn't be too late, our mapless path only partly resembled chaos as depicted by a two-year-old left alone for an hour in a large white room with a big black crayon.
- And for foreign visitors, who have only had access to the country for the last ten years, it might as well be a mapless frontier.
mappable adjective
- Example sentences
- The conservative project, to the degree that it still exists in a meaningful sense, exists in massive tension with neo-liberalism, and much of the contradictions of our world are mappable along this point of fracture.
- Is it hopelessly romantic to trust that human life, for all its knowable genetic specificities, lies in those larger territories, beyond commerce, for which there are no mappable equivalents?
- Work in the Appalachians has demonstrated the degree to which the implicit assumption, that shortening is accomplished by displacement on mappable fault planes, can lead to severe underestimates of the amount of shortening.
mapper noun
- Example sentences
- Last year farmers blocked access to the vegetation mappers.
- Matthews, a previous Pulitzer nominee for Where The Buffalo Roam, is a meticulous mapper of Manhattan's diverse animal population.
- Soon, political mappers will know more about you than the Department of Homeland Security.
Early 16th century: from medieval Latin mappa mundi, literally 'sheet of the world', from Latin mappa 'sheet, napkin' + mundi 'of the world' (genitive of mundus).
Words that rhyme with mapbap, cap, chap, clap, dap, entrap, enwrap, flap, frap, gap, giftwrap, hap, knap, lap, Lapp, nap, nappe, pap, rap, sap, schappe, scrap, slap, snap, strap, tap, trap, wrap, yap, zap
For editors and proofreaders
Syllabification: map
Definition of map in:
Modified American plan (see American plan).
For editors and proofreaders
Syllabification: MAP
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
= trending


text:
Loving Pugilist
You wanted Father Andrew Greeley as your friend and not your enemy. You got the sense he was born with his fists up and his loyalties fully formed. He was ready to do battle at the first signs of disrespect toward those he cared about.
Understanding Greeley, the priest, sociologist, and novelist who died last week at 85, is essential to understanding the last half-century of American Catholic history and the glorious contradictions of politics.
He was a liberal whose impatience with actual liberals was legendary. This applied especially to reformers who disparaged his beloved Daley machine in Chicago. Yet this resolute Irishman who once used the phrase "marginal but not alienated" as an apt sociological description of himself was bolder than so many others in the positions he staked out. Not one for understatement, Greeley titled one of his last books A Stupid, Unjust and Criminal War: Iraq 2001-2007.
Did I mention books? Greeley wrote so many that his obituary writers couldn't agree on a count. In a lovely New York Times article on Greeley, Peter Steinfels pegged the number at "more than one hundred and twenty." Joe Holley wrote in The Washington Post of "more than one hundred nonfiction works and fifty novels." John Allen risked precision in the National Catholic Reporter: seventy-two nonfiction books and sixty-six novels.
"I suppose I have the Irish weakness for words gone wild," Greeley told The New York Times in 1981. "Besides, if you're celibate, you have to do something."
Oh, yes, and he had a fine gift for revenge recast as generosity. He always harbored a grudge against the University of Chicago, which granted him a PhD in 1962 but denied him tenure eleven years later. He believed he was the victim of a classic form of academic prejudice: against Catholic priests.
But then he made piles of cash on his best-selling novels, typically described as "steamy." (The Cardinal Sins and Thy Brother's Wife sold in the millions.) So in 1984, he was able to endow a chair in Roman Catholic studies named after his parents at his former school. He was uncharacteristically diplomatic at the time, but everyone knew the joy he felt when a university that wouldn't offer him tenure was quite happy to take his money.
As Greeley might say, let me be clear: I loved the guy and owe him a deep intellectual debt. I began reading him in college and still think his 1972 book Unsecular Man: The Persistence of Religion is an underrated classic. Its first sentences are so completely Greeley: "Let us be clear at the beginning: this is a volume of dissent. It rejects most of the conventional wisdom about the contemporary religious situation."
Back then, when so many genuinely wise people thought religion was on an inevitable path to decline, Greeley insisted that it wasn't -- and more than four decades later, it's fair to say that Greeley got the better of the argument.
He was also a fierce champion of the white ethnic working class. A strong supporter of civil rights, he nonetheless hated what he felt was upscale liberal disdain for the Irish, the Poles, the Italians, and others who rose from the white immigrant working class. It infuriated him to see these people – his people -- dismissed as racist and their forms of ethnic consciousness denied legitimacy. It's no accident that as a Greeley-phile, I ended up writing a doctoral dissertation on the politics of race, class, and ethnicity.
And yes, he was a Catholic priest, an identity he cherished but in an oh-so-complex a way. Anyone he saw as unfairly attacking the church, its faithful and its institutions (particularly its schools) would face the full Greeley onslaught. But few could match his ire against the church on matters ranging from the pedophilia scandal (he was an early critic) to what he viewed as its wrong turn on birth control, whose costs he documented. He took on various bishops and archbishops with the alacrity of a schoolyard brawler.
Yet, to the end, he was incorrigibly Catholic. "For the last thirty years," he once wrote, "the hierarchy and the clergy have done just about everything they could to drive the laity out of the church and have not succeeded. It seems unlikely that they will ever drive the stubborn lay folk out of the church because the lay folk like being Catholic." Yes, and we liked Father Greeley because he spoke up for us. Who knows what the Almighty is in for?
(c) 2013, Washington Post Writers Group
About the Author
E. J. Dionne Jr. is a syndicated columnist, professor of government at Georgetown University, and a senior fellow at the Brookings Institution. His most recent book is Our Divided Political Heart: The Battle for the American Idea in an Age of Discontent (Bloomsbury Press).
4 comments
- All
- Editor Featured
Wonderful... thank you...would love to see a summary of your dissertaion also!
I loved Dionne's last paragraph. I felt I had a loud voice speaking for me in the person of Fr. Greeley. He really knew how the laity felt.
We were taught that the Church is the people of God. Often it does NOT feel that way. I think many of us haven't left because, in spite of it all, we feel an ownership. We continue regardless of the heirarchy. They think they know, but they don't. Greeley knew this and stood up for us. He will be sorely missed by the rank file Catholic.
And not to forget, he turned a great story. I loved his novels. May God rest his soul.
Would that we had more courageous priests who take on those in the hierarchy with pious bromides and "Father knows best.' attitudes in the face of an alarming ignorance of the lives of real people. Thanks for a great article.
I have the pleasure of knowing one of Andre Greely's nieces. After his tragic accident. -- before any of us knew about his permanent disability-- I asked her how he was doing. She said he had been in occupational therapy and the therapist asked him what his name was, and he had written, "Uncle." He was a wonderful, attentive uncle to his nieces and nephews, but he was also a literary and pastoral uncle to all of us who read his books, heard him preside and preach or attended lectures that he gave. He gave us advice and direction from his scholarship and experience that was immensely helpful and comforting. We Willis's him so!


text:
At first I thought I was crazy, but I've been keeping an eye out for it and it definitely happens on really rare occasions. I'll be fighting some enemies and when the battle ends, my life bar fills itself back up to full. In my last 2 hours of play or so, I've only seen it happen 3 times.
- I did not level.
- I don't have any gear that leeches health.
- I don't have any abilities that leech health.
- I did not accidentally drink a potion.
- I wasn't in or just coming out of Reckoning mode.
- In at least the most recent occasion, I had no blessings on me.
Anyone have any idea what might be triggering this?


text:
Chicago White Sox vs Toronto Blue JaysTue, June 11, 2013 - 7:10 PMUS Cellular Field in Chicago, IL
We are sorry, the date for this event has already passed. This event took place on 6/11/2013. Click here to view upcoming events for Chicago White Sox.
Still unsure? Check out our user reviews for:
Have a question? Need help? Call us at 800.477.5285


text:
History |
View |
Annotate |
Major changes to the gmake build files to simplify and improve.To use just type
$ make
Or for Visual C++
$ nmake
in the main source directory.
Copy VERSION .
Revert src back to r413 keeping changes in r420.
Reverted conversion of line endings from r414, back to Linux style
Changed almost all CPP HPP and H files to reduce warnings from Ubuntu build involving whitespace in code. All assignment operators should now be surrounded by spaces, all comments should be preceded by a space, all for loop constructs should have whitespace surrounding all statements.
Try Id again.....
Add svn 'Id'.
Copied revision 1006 from shibi to nceas. Old version control will now be only read only. This will be the primary version control.


text:
Denver International Airport
8500 Peña Boulevard, Denver, Colorado 80249-6340, USA
Telefon: (303) 342 2000
Website: www.flydenver.com
The airport is located 37km (23 miles) northeast of Denver.
How to get there
The airport access road, Peña Boulevard, can be accessed via an exit off I-70 in east Denver. I-70 offers connections to I-25, I-225 and I-76. Peña Boulevard can also be accessed from the E-470 Tollway and Airport Boulevard in Aurora.
Information about parking possibilities at the Denver International Airport
Access by public transport
RTD Skyride services (tel: (303) 299 6000 or 1 800 366 7433; www.rtd-denver.com) depart from the east side of the terminal on level 5, serving five routes
Taxis, charters and luxury limousines are available to all destinations.General ground transportation information is available (tel: (303) 342 4059), and there is a counter located on level 5 (from which all connections operate) of the terminal for assistance.
Information desk
An information desk is located in the terminal Arrivals level. Airport information is available (tel: (303) 342 2000).
Further travel information
- Back to the overview


text:
Lynne Dempsey
|Director of Athletics
|Previous College:
|Brandeis '93 MS '04
Dempsey began working in the Athletic Department as a part-time Assistant Facility Manager in June 1993, and joined the department full-time in August 1994. She has risen through the ranks from Facility Manager to Assistant Athletic Director, and was named Associate AD in 2004.
She was promoted to Senior Associate Athletic Director in 2013, and in September 2015 was named Acting Director of Athletics.
Her duties include team travel, game scheduling, event management, NCAA Compliance, as well as overseeing the day-to-day operations of the department. She also serves as a liaison with Academic Services, Public Safety, Facilities and the Dean's Office.
Dempsey graduated from Brandeis in May, 1993 with a degree in American Studies, and received her Masters Degree in Management from the Brandeis Heller School in 2004. As an undergrad at Brandeis, she was a four year member of the soccer, basketball and softball teams and was a captain of all three sports her senior year. She earned the University's Max I. Silber Award for outstanding female athlete her senior year.


text:
Balloon Magic
- 5 to 10 minutes
- Balloons
- Your young child is learning about gravity from trial and error. This activity challenges those emerging concepts with unexpected variations. Blow up a few balloons and tie them off.
- Rub each one on a wool carpet, sweater, or fur until enough electricity is generated so that when they are placed on the wall, they stick like magic. Note: dispose of all broken balloons immediately, as they pose a serious choke hazard.
- When the balloon is electrified, it can be used to attract and lift your hair.
- Blow up balloons of different colors and stick them to the wall in similar groupings.
- Inflate them so that some are larger and sort onto the wall by size.
Copyright © 2004 by Susan Kettmann. Excerpted from The 2,000 Best Games & Activities with permission of its publisher, Sourcebooks, Inc.
To order this book visit Amazon.com.


text:
- Binding: Hardcover (USAC)
- Era: Napoleonic Era
- Number of Pages: 176
- Subject: Naval History
- Date Available: August 2011
Clear The Decks Price*
Your tax-deductible gift to the Naval Institute Press underwrites worthy books that might not otherwise be published.
Between 1793 and 1815 two decades of unrelenting naval warfare raised the sailing man of war to the zenith of its effectiveness as a weapon of war. Every significant sea power was involved in this conflict, and at some point virtually all of them were arrayed against Great Britain. A large number of enemy warships were captured in battle and the Admiralty ordered accurate drafts to be made of many of these prizes. Consequently, ships from the navies of France, Spain, the United States, the Netherlands, Denmark, Sweden, as well as from Britain, were illustrated by an unprecedented variety of paintings, drawings, models or plans.
Robert Gardiner is the author of a number of books, including Frigates of the Napoleonic Wars and resides in England.
Praise for Warships of the Napoleonic Era
"The book itself is handsomely produced. I think any serious naval researcher of the 1793-1815 wars would be most pleased to have this handy on the shelf."
— International Journal of Maritime History, December 2011


text:
There are ATMs practically everywhere in Europe and the UK including a cashpoint in the Nido lobby. Most students find this to be the easiest way to get cash. However, before you leave, speak to your bank about (1) the high fees they may charge for overseas use and (2) not flagging your account as fraudulent due to the overseas use.
To counter the large fees some students take out large amounts of cash at one time. If you choose to do that be careful and watch out for pickpockets!
Western & Northern Europe:
Used in most places.
Eastern & Southern Europe:
Many places do not accept credit cards. Those that do more widely accepted MasterCard and Visa over AMEX.
as of June 2015
$1.00 = 0.63 Pound (£)


text:
Subscribe to RSS Feed
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|Show per page
LockState LS-30D FireProof Safe
The LockState LS-30D is a solid fire resistant safe with an electronic lock and 2 user codes. Protect your valuables and documents from fire with temperatures up to 1850 degrees (f) for 1 hour. The electronic lock and override keys ensure that you will never be locked out and the dual locking bolts ensure that burglars can't get in. Learn More
LockSate SafeCase Biometric Safe
The new & improved SafeCase features an optical finger print scanner for superior fingerprint recognition. No more swiping. Just place your finger on the scanner to unlock. Learn More
LockState 50D 1 Hour Fireproof Electronic Safe
The LockState LS-50D Electronic 1-Hour Fireproof Safe protects valuables from damage caused by fire or extreme heat. Keep your cash, passports, social security cards, birth certificates, deeds, and other important documents safe from fire or burglary. Equipped with a large live-locking bolt and two stationary deadbolts, the LS-50D is designed to not only keep your valuables safe from fire, but safe from intruders as well. Two stationary deadbolts lodge into the body of the safe to prevent the door from being removed even if the hinges are compromised. With a pre-drilled mounting hole and mounting hardware included, the LS-50D can be secured to the floor for added security. The sleek electronic lock with large LED screen allows for quick and easy access to your belongings. Learn More
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text:
A southern Illinois judge has ruled that a 14-year-old McLeansboro boy should be housed in a juvenile detention center in connection with a Saturday night stabbing.
The victim, Alex A. Carr, 22, McLeansboro, is in stable condition at Deaconess Hospital in Evansville, Ind., after undergoing surgery for a stab wound to his back.
The stabbing happened around 10 Saturday night on a sidewalk near a bank in downtown McLeansboro. Hamilton County State's Attorney Justin Hood told WFIW Radio the 14-year-old suspect made an appearance in court Monday where Circuit Judge Barry L. Vaughn ordered he be detained pending further proceedings in juvenile court.
The teen has been formally charged with a class 3 felony charge of aggravated battery. An adjudicatory hearing has been set for 1:30 p.m., Monday, Aug. 19, in Hamilton County Circuit Court in McLeansboro. Until then, the suspect will remain in the Franklin County Detention Center in Benton.
Location, ST | website.com


text: I know you know who you are looking at here. It's actually Randall Boggs from Monsters Inc. but in Monsters University he goes by the name Randy. In Monsters University Randy is geeky looking. He has a more mild appearance and seems less menacing. Now I don't know if his personality or drive is toned down a bit from what he turned into as he got older, but I do know that he will be one of the characters to pay attention to. Drawing Randy from Monsters University will be fun, and exciting. If you have been waiting for this lesson, here it is now. Peace out and enjoy.


text:
Top Stories
School Funding Concerns
Issues Impacting All Districts
Dear Parents and Community Members, One of the hallmarks of our great school district has always been providing the best education we can for our students, while being conservative in the use of our funds. That conservative nature allowed us to build healthy fund balances when times were better, which has helped sustain us in the more difficult times we have faced in terms of funding and finances overs the last . . .
Fall Registration August 9th
School Starts August 24th
Registration Day for the 2016-17 school year for all students will be held on Tuesday, August 9, from 10:00 a.m. - 6:00 p.m. at Parkside School. After reviewing the information below, please feel free to contact your child's school or the superintendent's office at 815-223-1111 (extension 5) for more information. School Supplies If you did not order through the School Tool Box online . . .
Get Involved with PTC!
2016-17 Meeting Dates Announced
We would like to welcome ALL parents to get involved with the Peru Schools Parent-Teacher Club! PTC is a great way to become involved in your child's school. We are all volunteers and need everyone's help to ensure a fun and exciting year for our children. PTC meets on certain Tuesdays at 6:00 p.m. Parents, teachers and school leaders meet together to plan activities throughout the year. Some r ecent . . .
Northview Special Events
2015-2016 Snapshots Northview Grand Opening . . .
Parkside Special Events
2015-2016 7/8 Honors Breakfast . . .
Parkside Athletics
It is the philosophy of Peru Elementary School District #124 that al l students are encouraged to participate in extra curricular . . .


text:
|Welcome to the world of Pokémon, Midori Phénix!
|Welcome to Pokémon Wiki, and thank you for your contributions! There's a lot to do around here, so I hope you'll stay with us and make many more improvements.
I'm really happy to have you here, and look forward to contributing with you!
|Your administration:
Energy X (talk) • Rainbow Shifter (talk) • Shockstorm (talk) • Avingnon (talk) • Yoponot (talk) • Remaai (talk) • Lordranged7 (talk)
- -- Rainbow Shifter (Talk) 19:04, December 8, 2012
Re: Hello
This sort of message really infuriates me, especially if it is written by a person who has been here for 1 or 2 days. You need a lot more experience before becoming an admin. You need to have a lot of good edits, have been here for a long time, be active, be nice and helpful, have read the rules and stick to them. You cannot expect to be made an admin after making 6 edits (only 2 of which are actually on articles) and of only being here a day. Before I was made an admin, I never asked to be made means, I just was because I edited a lot and was active. You need to realise the commitment you need to put forward to be an admin.
Plus, if you really want to be an admin you should have actually read our rules, Wikia's rules and have realised that only Beaucrats can make people an admin and I am not one of them. If you seriously want to be an admin then I suggest you edit more and be active. Maybe in a years time you might actually be considered. Rainbow Shifter 16:47, December 9, 2012 (UTC)


text:
A suspect in a Boynton Beach home invasion has been taken into custody.
The home invasion happened in the 200 block of Southwest 11th Avenue on Monday afternoon.
Ismith Jean said he returned to his house in the 300 block of Southwest 13th Avenue and came face to face with the suspect, who was hiding in his daughter's closet.
"I said, 'Get out of here before I call the police on you,'" Jean told WPBF 25 News.
It turns out the man was a suspect wanted in connection with a home-invasion robbery earlier in the day.
Police said the suspect, armed with a machete, broke into a home and demanded money from the resident. Police said he then made his way throughout the neighborhood, demanding money from people on the street.
After a massive search by air and land, the suspect was eventually apprehended. He was identified as Kerven Charles, 19.
No injuries were reported.
More From WPBF: Email alerts | Mobile | Social


text:
Another great week of awesome projects. Like I said before, you two are
out of control. One day is better than the other. But we are the
lucky ones that get all your ideas and the motivation to create these
wonderful projects. Thanks for sharing. You are blessed with a
wonderful gift.
Have a great rest of your weekend!
Be sure and check out Joy's and Melanie's personal blogs for more creative goodness at Obsessed with Scrapbooking and Courtney Lane Designs! Click HERE to learn how to leave comments.
Click HERE to learn how to find OVER 600 project ideas on this site! Have a great day!
Subscribe to Everyday Cricut to learn more about ways to use the Cricut in your cardmaking and scrapbooking!


text:
23 Jun 2011 4:17 AM #1
4.0.2 Ext.form.field.Number : force decimal precision in string value.
Here is two (very) simple modifications for "numberfield" prototype.
For beginners ...
A new param "forceDecimals", to force formatting of the string value with as many decimals than "decimalPrecision".
Eg :
decimalPrecision : 2
forceDecimals : true
value : 125.2
=> display/submit value : 125.20
I'm not a javascript expert ...
Comments, criticals or suggestions are welcome ...
bonus track ... As french user, I use "," (comma) as decimalSeparator. A simple way to use "." (dot) as secondary allowed decimalSeparator is to allow it in baseChars ...
So you can use any of them (useful to allow copy/paste from others software using dot as decimal separator)...
if (Ext.form.field.Number){ Ext.apply(Ext.form.field.Number.prototype, { // force decimals string value forceDecimals : true, valueToRaw: function(value) { var me = this,decimalSeparator = me.decimalSeparator,precision = me.decimalPrecision,forceDecimals = me.forceDecimals; value = me.parseValue(value); value = me.fixPrecision(value); value = Ext.isNumber(value) ? value : parseFloat(String(value).replace(decimalSeparator, '.')); if (isNaN(value)) return ''; else { value = String(value).replace('.', decimalSeparator); if (value.indexOf(decimalSeparator)>=0 && forceDecimals) { var dec = value.substr(value.indexOf(decimalSeparator)+1); for(var i=dec.length;i<precision;i++) { value = value+"0"; } } return value; } }, // allow dot as decimalSeparator even if this is not the locale setting baseChars : '0123456789.', }); }
29 Jun 2011 3:43 AM #2
You might want to take a look at regular expressions.
Out of my head (so not checked):
PHP Code:
xtype: 'text',
// forcDecimals: true, numDecimals 2
regex: /^[0-9]+(.|,)[0-9]{2}$/,
regex: new RegExp(
'/^[0-9]+((.|,)[0-9]{'+numDecimals+'})'+ (!forceDecimals ? '?':'') +'$/',
29 Jun 2011 7:44 AM #3
@JanVenekamp : "You might want to take a look at regular expressions."
Thanks for your suggestion.
You're right ... but there is a problem ... I HATE regular expressions !
First, I think that RegEx is very powerfull in complex cases but absolutely not intuitive (even good programmers have to double check their expressions ) and sometinmes useless for simple checks.
But also, few years ago, I had to code a PHP function to check if a string was present in long html source codes.
I used RegEx and the result was very time consuming...
So, I used a simple string search and the execution time was reduced by 5 ...
But as you're right on the principle, I do not want to keep this bad experience as reference. So, I just write a single JS test to compare again the two methods in a loop.
Checking with RegEx VS string function.
1 - Using string function to test AND set correct value :
var start = new Date; for (var t = 0;t<1000000;t++) { var value = "10."; if (value.indexOf(".")>=0) { var dec = value.substr(value.indexOf(".")+1); for(var i=dec.length;i<2;i++) { value = value+"0"; } } } var end = new Date; console.log(end.getTime()-start.getTime());
2 - Using RegEx, just to check value :
var start = new Date; for (var t = 0;t<1000000;t++) { var value = "10."; var reg = new RegExp('/^[0-9]+.[0-9]{2}$/'); var test = reg.test(value); } var end = new Date; console.log(end.getTime()-start.getTime());
Definitely, I do not like RegEx ...
Of course, this test is based on a "1000000" loop ... in "real life", difference is insignificant
but RegEx is really a time consuming method ...
29 Jun 2011 7:34 PM #4
What if you took the new RegExp(...) out of the loop?
29 Jun 2011 11:55 PM #5
With "new RegExp" out of the loop, RegExp wins ...
var value = "10.2"; var reg = new RegExp('/^[0-9]+.[0-9]{2}$/'); var start = new Date; for (var t = 0;t<1000000;t++) { if (value.indexOf(".")>=0 && value.substr(value.indexOf(".")+1).length < 2 ) { // set value } } var end = new Date; console.log(end.getTime()-start.getTime()); start = new Date; for (var t = 0;t<1000000;t++) { if (!reg.test(value)) { // set value } } end = new Date; console.log(end.getTime()-start.getTime());
RegExp test : 102
So, you're right, using one RegExp to test many string is a quicker method.
But in this example, I think that use a RegExp to check a field value means declare it each time.
So, unless I'm wrong, we have to let it in the test loop ?
Of course, "I hate RegExp" was a joke (even if I really hate it ) because it's a powerful and useful function.
What I mean is that using RegExp seems more effective, but ... not always ...
30 Jun 2011 4:31 AM #6
@pkli Learning regular expressions can be a , but once you master the basics it's very handy. The one line regex is far more easier to write and interpret for someone who knows regex than 10+ lines of code.
30 Jun 2011 5:08 AM #7
To be a little serious, I think of course you're right in a global approach...
Coding is like anything else ... several ways to get the same result.
As I work alone, I use the easiest way according to my knowledge.
But I promise to take a couple of hours asap to perfect my RegExp knowledge and to reconcile myself with it ...
Thank you for your advice !
21 Sep 2011 5:26 AM #8Greivin Britton
My Extensions:
Ext.ux.NumericField: Number field with support for currencySymbol, thousand separator, international...
Ext.ux.PagerSizeSelector: A plugin that allows the change page size with just one click.
Ext.ux.FieldAccess: A plugin to let the user know which fields are editable.
28 Jan 2013 2:05 PM #9
I can't fine forceDecimal in config. Is it no longer in Ext. JS 4.1.3 or maybe it was put somewhere else


text:
NN3 has been upgraded and improved with a newer rotator and detent rings.
Improvements include:
* No inner lock screw, tension is easily adjusted by simply tighten the upper knob.
* Inner ball bearing replaces detent pin. This allows for a more positive feel and increased wear.
* Rubberized metal knurled knobs. This not only allows for a better gripping but also creates a better feel and enhanced look.
We will be selling the lower rotator assembly separately for current owners of NN3 (first edition) with an estimated website price of $40. This will replace the upper and rotator knobs. The newer MKII detent rings are not interchangable. You will note by the image of the lower rail of the MKII the design as changed slightly as well and with the rings themselves. You will however be able to use your original rings as you are not changing the lower rail.


text:
Members of the media who wish to reach students, faculty, staff, or a spokesperson of the College, please email Media Relations or call 802-440-4399.
Bennington College
Office of Communications
One College Drive
Bennington, VT 05201-6003
Visual arts faculty member Ann Pibal's small-scale paintings are on view
in a group exhibition at Sikkenma Jenkins & Co Gallery on West 22nd
St., New York.
The exhibition, running through July 27, features
paintings by eight contemporary artists who predominately work in small
or modest scale. "Small paintings intimate the domestic and the
personal," says Pibal. "They create a space the size of one viewer at a
For more information, click here.


text:
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With a UNC Lineberger e-news subscription, you will receive periodic updates containing the latest information about:
- important breakthroughs in cancer research, treatment and prevention
- the University Cancer Research Fund (UCRF)
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Once subscribed, you may unsubscribe at any time. The email information that you provide will only be used by UNC Lineberger and will not be shared with a third party. Email Marketing You Can Trust


text:
TEMPLE (February 10, 2013)—A line of thunderstorms that rumbled through Central Texas early Sunday morning downed power lines, limbs, and in one area of Temple a number of trees including one that fell on a house.
There were also reports of heavy damage along St. Joseph Road in the Burlington area, south of Rosebud in Milam County.
The storms caused scattered power outages and about 1,000 area customers were without service by mid-morning Sunday.
Severe thunderstorm warnings were in effect early Sunday for most of Central Texas and tornado warnings were issued for Leon, Limestone and Freestone Counties.
The storms caused significant damage in the Western Hills area of Temple, uprooting trees along West Adams Avenue, Apache Drive and Blackfoot Drive, Temple Fire & Rescue said Sunday.
In the Whispering Oaks subdivision, a tree fell on a house.
The sole resident escaped injury and was staying with relatives Sunday.
High winds peeled off an awning and a portion of the roof at Brentwood Apartments at 3000 West Adams Ave. damaging four units and displacing 10 residents who are staying temporarily in vacant apartments or with relatives.
Winds destroyed business signs at Quick Shop and Go at Olaf and West Adams and New Hope Community Church at2 Apache Dr.
The storm downed fences along Saulsbury Drive and blew over satellite dishes on Moody Lane.
SportsRadio 101.7 The Ticket was knocked off the air when a dish was blown over, but is now running on a backup feed, the station's brand manager, Jamie Garrett, said in an e-mail.
Temple Fire & Rescue personnel responded to storm-related calls from around 3:20 a.m. until just before 5 a.m. Sunday.
A storm spotter reported that the wind snapped a telephone poll in half two miles southwest of Temple.
The high wind also caused damage to docks at Frank's Marina on Lake Belton, uprooting shore moorings and shearing underwater anchorages.
In Elm Mott, high winds ripped the roof off of a shop building at around 3 a.m. Sunday at 1070 Gerald Lane.
The sound of the wind awakened the resident, Denny Downs, who discovered the roof of the shop had been carried away and that debris was spread over a 10-acre radius, Downs' son Jesse said.
No one was injured.


text:
In the season 5 finale of Grey's Anatomy, they left us wondering what was going to happen to George and Izzie. What do you guys think will happen to them?
I heard that George, in his real life, said he did not want to be on the show anymore. So does it mean that he is going to die in the following season? I like him and I really don't want George to go, he is one of my idol.
Actually, I think Izzie is going to die because she was on the elevator and George was not.


text:
Possible Duplicate:
Eigenvalues of an operator
Find all the functions $f \in C([0,\frac{\pi}{2}])$ which are solutions of $$ f(x) = \lambda \int_0^{\pi/2} \cos({x-y)}f(y)\,dy, \qquad \lambda \in \mathbb R. $$
I just tried some algebraic manipulations and calculations, but I do not know ho to face this problem. Any help or hint is welcomed. Thanks a lot.


text:
14 May 2012 3:00 AM #1
Paging problem
I have a grid based on 4.07 with paging function and it is working fantastic. After I change in my app.html to us Ext4.1 there are no page numbers anymore and it says no data to display, but there are 50 of 2800 records displayed. Maybe there is someone else having this problem? I did not change anything else but I have to use 4.1 for the row checking function
14 May 2012 3:19 AM #2
Sorry, but I do n't know how to delete this thread. But I found my problem (buffered:true)!!!


text:
View the entire directory online or use the links below to go directly to these sections:
Industry Resource Guide
DHI is pleased to present the annual consolidation of the Buyer's Guide, the Distributor Directory, and the Consultants Directory, with all new listings this year to include a Wholesale Distributor Directory, a Sales Agency Directory, and a Fire Door Assembly Inspectors Directory. Whether you need information on manufacturers, products, suppliers, distributors, spec writers, inspectors or consultants, you'll find it all in this unique, comprehensive Resource Guide for the openings industry.
DHI is the leading voice of the openings industry, and its publications are the most widely read in print and online. Specifically targeted to audiences within the distribution channel, our readers are the architects, distributors, specifiers and decision makers at companies around the globe. We are the source they depend on for information regarding code issues, trends, education and networking. As a result, DHI is ideally situated to promote communication between sales agents, distributors, manufacturers, consultants and consumers. No matter what you need, you'll find listings of individuals and companies that are capable of providing custom-designed solutions for your job.
By serving as a conduit to help build alliances and relationships, DHI will strengthen your position as an expert working to safely secure the built environment. We hope that you'll retain this issue as a year-round resource in print and online and that you will use it monthly, weekly, if not daily as you discover industry news, learn best practices, and build a mutually beneficial network with some of the industry's best companies and leaders. Visit www.dhi.org and click on "Publications" to access this edition of Doors + Hardware magazine year round!


text: On Thu, Mar 29, 2007 at 02:18:28PM -0500, email@example.com wrote: > I want to eliminate some portions of the pages on our site from indexing - > I've marked them in the HTML with specially formatted HTML comments. Ignore parts of pages or the entire pages? To ignore parts of pages (e.g. menus, headers, footers) you can use these comments: <!-- noindex --> <!-- index --> > The way I made it work was to add this code at the very top of > output_content in spider.pl (V 1.26): > > if ( my $fn = $server->{alter_content} ) { > eval { > $fn->($server, $content, $uri, $response); > }; > die "alter_content died for $uri: $@\n" if $@; > } > > Is this a good way to accomplish it? I put my actual logic in the config > file of course. Sure -- you can hack it to fit your needs. > I could have also used the existing output_function callback, but there is a > lot of miscellaneous stuff that happens after that call before the output > that I would have to replicate in my code if I did so. That's rather late in the process -- what happens after that makes that not useful? -- Bill Moseley firstname.lastname@example.com Unsubscribe from or help with the swish-e list: http://swish-e.org/Discussion/ Help with Swish-e: http://swish-e.org/current/docs _______________________________________________ Users mailing list email@example.com http://lists.swish-e.org/listinfo/usersReceived on Thu Mar 29 17:54:59 2007


text:
The choices in insurance policies are baffling. But finding an insurance tailored for you can be troublesome.
Any type of insurance whether it be car, life, home, fire or pet insurance poses a challenge to the most seasoned shopper. This is because there isn't any tangible, physical thing to handle.
Super Visa Insurance needs vary depending on personal situation. If one does not have dependents, then it is different scenario altogether in comparison one with a family.
If the salary is important to supporting your family, paying the mortgage or other recurring bills, or sending your kids to college, insurance is important to ensure that these financial obligations are covered in the event of your death.
But do remember don't let an agent talk over your head with terminology. Tell him or her to slow down and speak English. After all, they are trained in their particular lingo, which a common man fails to understand.
It's difficult to apply a thumb rule because the amount of insurance you need depends on factors such as your other sources of income, how many dependents you have, your debts, and your lifestyle. The general guideline is between five and ten times your annual salary. Buying insurance is a long term commitment. Be sure you get the right policy. Ask questions and be sure you understand the clauses.
Compare different policies, figure out the average cost and make sure you know everything. Do not sign it without reading and understanding it fully. Clarify the clauses regarding penalties for allowing coverage to lapse and if they can be waived in certain circumstances. This should be a standard across the industry.
It is much easier and faster to do these tasks online. Online insurance has some unique benefits. The information is in writing and in this way, one can go over it, again and again. No back tracking on the agent's part and no shocking surprises 3 months down the line.
There are immense possibilities. There are numerous websites where one can clear and verify doubts. Don't rush, don't get lost in terms, compare a few policies and be aware of the penalties that is the fundamental rule.


text:
Home > Subaru > Subaru Outback 2013
Below you will find the high resolution car photo for Subaru Outback 2013. You may use the car photo for any of the following widescreen screen resolutions:
1920x1200 | 1680x1050 | 1440x900 | 1280x800
Subaru Outback 2013
When the upcoming model of Subaru, the 2013 Subaru Outback, was showcased at the New York Auto Show, everyone around were almost forced to give the redesigned front fascia a look. While the rear end of the car has been kept unchanged, the redesigned front-fascia (enhanced grille with the headlights on the extension of the grille and fog lamps) has done it all. Moreover, its all-wheel drive traction ensures a safe and hassle-free drive even in the bad weather and uneven terrains.


text:
Stress Targets PFC Glutamate Receptor Turnover
19 March 2012. Stressful experiences impair memory and turn down glutamate signaling in the prefrontal cortex (PFC) of rats, according to a study published March 8 in Neuron. Led by Zhen Yan at State University of New York in Buffalo, the study finds that repeatedly stressing juvenile rats accelerates glutamate receptor turnover at the synapse, and stalling turnover undoes the effects of stress.
The relevance of the findings to mental illness is not immediately apparent, but there is hope that understanding the neural consequences of stress may provide clues to the formation of vulnerable brain states (de Kloet et al., 2005). Stressful events trigger release of stress hormones like cortisol, which then activates glucocorticoid receptors. This sets off a host of effects in the brain, resulting in altered behavior and structural changes in neurons (see SRF related news story). Taking a physiological perspective, the new study turns up dampened glutamate signaling specific to the PFC that is reminiscent of findings in schizophrenia (see SRF hypothesis). This suggests that the pattern of stress matters, as Yans group has previously linked an acute episode of stress with improved memory and increased glutamate signaling (Yuen et al., 2009).
In search of lost time
Because the brain is particularly sensitive to stress during adolescence, first authors Eunice Yen and Jing Wei studied the juvenile rat equivalent in a repeated stress paradigm that immobilized rats in a restraining tube two hours a day. After seven days of this, the rats were tested in a temporal order recognition memory task, which measures the ability to discriminate between objects encountered at different times in the past, and which requires medial PFC (Barker et al., 2007). The rats explored one object, followed by a different object one hour later. When presented with both objects three hours later, control rats spent more time exploring the first, less recent object, but the stressed rats lost this preference; however, they spent the same total time exploring the objects as controls did.
This deficit was attributed to activation of glucocorticoid receptors in the PFC because delivering RU486, a glucocorticoid receptor blocker, into the PFC 40 minutes before each stress session resulted in rats that could discriminate just as well as unstressed controls.
Dampened glutamate signaling
The state of glutamate signaling came under suspicion in these stressed rats, because injecting the PFC with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor blockers in control, unstressed rats produced a similar temporal order memory deficit. To explore this further, the researchers recorded from pyramidal neurons in PFC slices. In stressed rats, they found diminished glutamate-induced currents: compared to controls, AMPA-receptor currents were 40-60 percent smaller (depending on stimulus intensity), and NMDA-receptor currents were 38-57 percent smaller. Mini-analysis pointed to the post-synaptic side as mediating these decreases. These changes might be specific to PFC, because they were not found in hippocampus or striatum. Like the memory impairments, this dampened glutamate signaling did not transpire in stressed rats also receiving RU486 injections to PFC before each stress session.
To see if these changes stemmed from a decrease in the number of AMPA and NMDA receptors available at the surface for receiving glutamate signals, the researchers compared surface and total levels of receptor subunits using a method that labels the surface pool. In stressed rats, they found about half the level of surface subunits as that found in controls, and for GluR1 (a subunit in AMPA receptors) and NR1 (a subunit in NMDA receptors) specifically, this was also true for the total levels. Total levels of other synaptic and dendritic markers such as MAP2 were not affected by stress, which suggests that these subunit decreases did not merely reflect structural losses of dendrites or synaptic boutons, but rather a specific loss to the receptor composition of the post-synaptic membrane.
Stop the degradation
The researchers next explored whether the stress-induced loss in total levels of GluR1 and NR1 reflected a decrease in their synthesis or an increase in their breakdown. Repeated stress did not change mRNA levels of these subunits, arguing that synthesis was running normally. To measure protein degradation, the researchers measured the levels of GluR1 and NR1 proteins tagged for destruction by ubiquitin, and found nearly twice the amount in stressed rats compared to controls.
To interfere with the destruction of ubiquitinated proteins, the researchers infused MG132, which blocks the action of the cells protein-destruction chamber, into the PFC one hour before each stress session. This resulted in fairly normal AMPA- and NMDA-receptor currents in stressed rats, which did not differ significantly from unstressed animals injected with saline or MG132 alone. Surface and total protein levels of the GluR1 and NR1 subunits were also normal. MG132 infusions also blocked the stress-induced deficits in temporal order memory.
Looking one step upstream of degradation, the researchers found that RNA interference-mediated knockdown of the ligases responsible for tagging these subunits with ubiquitin mitigated the effects of repeated stress. Knockdown of Nedd4-1, a ligase that tags GluR1, and Fbx2, a ligase that tags NR1, did not produce the stress-induced increase in ubiquitination of GluR1 and NR1, respectively, nor the decrease in AMPA and NMDA receptor currents, respectively. In fact, the measurements were similar to those found in unstressed controls. Bringing the story full circle, knocking down both ligases prevented the stress-induced deficit in temporal order memory. Both Nedd4-1 and Fbx2 were expressed at higher levels in PFC compared to hippocampus and striatum, which might account for the region-specificity of these findings.
The findings highlight the notion that the ubiquitin protein degradation pathway does more than housekeeping for a cell. A role for the ubiquitination pathway has recently emerged in the remodeling of neural networks (Mabb et al., 2010), and gene expression profiling has fingered abnormalities in this pathway in schizophrenia (Middleton et al., 2002; Bousman et al., 2010). Though future work will have to connect the dots between glucocorticoid receptor activation and Nedd4-1 and Fbx2 activity, the findings identify some molecular consequences of stress that offer new ways to think about its role in mental illness.Michele Solis.
Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron. 2012 Mar 8;73(5):962-77. Abstract


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19 Dec 2012 2:54 PM #1
Can Navigation Bar be undocked?
Can the navigation bar from the navigation view not be docked to the top?
I want it to scroll with the container. Thanks!
20 Dec 2012 7:29 AM #2
I would hide my navBar, add my own toolbar to the container with the list so it scrolls.


text:
Digestive Disorders Health Center
Cirrhosis of the Liver
In this article
The liver weighs about 3 pounds and is the largest solid organ in the body. It performs many important functions, such as:
- Manufacturing blood proteins that aid in clotting, oxygen transport, and immune system function
- Storing excess nutrients and returning some of the nutrients to the bloodstream
- Manufacturing bile, a substance needed to help digest food
- Helping the body store sugar (glucose) in the form of glycogen
- Ridding the body of harmful substances in the bloodstream, including drugs and alcohol
- Breaking down saturated fat and producing cholesterol
Cirrhosis is a slowly progressing disease in which healthy liver tissue is replaced with scar tissue, eventually preventing the liver from functioning properly. The scar tissue blocks the flow of blood through the liver and slows the processing of nutrients, hormones, drugs, and naturally produced toxins. It also slows the production of proteins and other substances made by the liver.
Recommended Related to Digestive Disorders
10 Questions for Doctor About Chronic Constipation
Since you were recently diagnosed with chronic constipation, ask your doctor these questions at your next visit. What is chronic constipation? Is my chronic constipation a sign of a serious disease such as colon cancer? Can the medications I take be the cause of chronic constipation? What medical tests can help determine the cause of chronic constipation? Are psyllium powder mixes or other over-the-counter (OTC) remedies effective for ending constipation? If I've been taking ...
Read the 10 Questions for Doctor About Chronic Constipation article > >
According to the National Institutes of Health, cirrhosis is the 12th leading cause of death by disease.
What Causes Cirrhosis of the Liver?
Hepatitis C, fatty liver, and alcohol abuse are the most common causes of cirrhosis of the liver in the U.S., but anything that damages the liver can cause cirrhosis, including:
- Fatty liver associated with obesity and diabetes
- Chronic viral infections of the liver (hepatitis types B, C, and D; Hepatitis D is extremely rare)
- Blockage of the bile duct, which carries bile formed in the liver to the intestines, where it helps in the digestion of fats; in babies, this can be caused by biliary atresia in which bile ducts are absent or damaged, causing bile to back up in the liver. In adults, bile ducts may become inflamed, blocked, or scarred, due to another liver disease called primary biliary cholangitis.
- Repeated bouts of heart failure with fluid backing up into the liver
- Certain inherited diseases such as:
- Cystic fibrosis
- Glycogen storage diseases, in which the body is unable to process glycogen, a form of sugar that is converted to glucose and serves as a source of energy for the body
- Alpha 1 antitrypsin deficiency, an absence of a specific enzyme in the liver
- Diseases caused by abnormal liver function, such as hemochromatosis, a condition in which excessive iron is absorbed and deposited into the liver and other organs, and Wilson's disease, caused by the abnormal storage of copper in the liver
Although less likely, other causes of cirrhosis include reactions to prescription drugs, prolonged exposure to environmental toxins, or parasitic infections.
Today on WebMD
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Our children loved this activity. It kept them envolved for hours
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Comments about Fuse Bead Snake Craft Kit :
We made these at camp with all age groups. The older campers made them first and then paired up with younger campers to help them.
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