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Here the back of the embryo can be seen lying over the yolk sac. The opening overlying the developing brain has now closed (left side of image) and this will be followed two days later by closure of the opening at the base of the spine (out of view).
Your developing embryo may still be tiny, but is undergoing rapid and complex development.
The heartbeat is now more easily recognized on an ultrasound scan. The heart continues to form from a simple smooth tube which, as it becomes more muscular, loops, folds, and divides to form four chambers. On the left side the upper chamber (left atrium) takes in blood from the lungs. From here blood passes through a one-way valve (the mitral valve) into the main left pumping chamber (the left ventricle). This then pumps blood out of the heart to the body along the main artery (the aorta). On the right-hand side of the heart, the upper chamber (right atrium) collects blood returning from the body and passes it through a one-way valve (tricuspid valve) into the right main pumping chamber (right ventricle). This pumps blood to the lungs and the cycle continues.
At this stage of development, the circulation is very basic with the heart tube simply sending blood around the length of your baby. No blood travels from your baby's circulation to the placenta (see You are 10 Weeks Exactly).
At this early stage, a common concern is that the pregnancy will miscarry. A miscarriage is the spontaneous loss of a pregnancy at any time up until the 20th week. After 20 weeks the loss is referred to as a stillbirth. The signs of a miscarriage are vaginal bleeding and periodlike cramps.
Unfortunately, there is nothing that you can do to prevent a miscarriage. In around 60 percent of cases, it is caused by a one-time genetic problem. Bleeding does not always mean that the pregnancy is being miscarried. Since not all miscarriages follow the same pattern, there are various terms to describe what happens:
Excerpted from Pregnancy Day by Day.
Copyright © 2008 Dorling Kindersley Limited.
Buy this book now!
© 2000-2016 Sandbox Networks, Inc. All Rights Reserved.


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Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
Evolutionary Biologist Dies
January 2, 2013|
Carl Woese, the discoverer of the third domain of life, has passed away at age 84.
January 2, 2013|
Carl Woese, the discoverer of the third domain of life, has passed away at age 84.
January 1, 2013|
In the final chapter of his book on the origins of vertebrate sex, author and paleontologist John Long pays homage to the humble placoderm, which got the erotic ball rolling.
January 1, 2013|
The rise of copulation as a vertebrate reproductive strategy may have driven crucial evolutionary change and explosive species radiation.
January 1, 2013|
How photosynthetic organisms get taken up, passed around, and discarded throughout the eukaryotic domain
December 20, 2012|
Comparing gene transcripts from different species reveals surprising splicing diversity.
December 19, 2012|
This year, US politics was dominated by the run-up to October elections, with science policy issues playing a role here and elsewhere around the world.
December 12, 2012|
Fat cells behave differently in obese individuals, causing inflammation and insulin resitance.
December 10, 2012|
The healing powers of maggots may lie in their secreted proteins, which restrain the human immune response.
December 10, 2012|
Archaea packages DNA around histones in a similar way to eukaryotes, suggesting that fitting a large genome into a small space was not the original role of chromatin.
December 6, 2012|
Adipose tissue plays an immune role in individuals of normal wieght.

subset: commoncrawl


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$\mathfrak{sl}_2(\mathbb{C})$ is usually given a basis $H, X, Y$ satisfying $[H, X] = 2X, [H, Y] = -2Y, [X, Y] = H$. What is the origin of the use of the letter $H$? (It certainly doesn't stand for "Cartan.") My guess, based on similarities between these commutator relations and ones I have seen mentioned when people talk about physics, is that $H$ stands for "Hamiltonian." Is this true? Even if it's not, is there a connection?
Both terminology and notation in Lie theory have varied over time, but as far as I know the letter H comes up naturally (in various fonts) as the next letter after G in the early development of Lie groups. Lie algebras came later, being viewed initially as "infinitesimal groups" and having labels like those of the groups but in lower case Fraktur. Many traditional names are not quite right: "Cartan subalgebras" and such arose in work of Killing, while the "Killing form" seems due to Cartan (as explained by Armand Borel, who accidentally introduced the terminology). It would take a lot of work to track the history of all these things. In his book, Thomas Hawkins is more concerned about the history of ideas. Anyway, both (h,e,f) and (h,x,y) are widely used for the standard basis of a 3-dimensional simple Lie algebra, but I don't know where either of these first occurred. Certainly h belongs to a Cartan subalgebra.
My own unanswered question along these lines is the source of the now standard lower case Greek letter rho for the half-sum of positive roots (or sum of fundamental weights). There was some competition from delta, but other kinds of symbols were also used by Weyl, Harish-Chandra, ....
ADDED: Looking back as far as Weyl's four-part paper in Mathematische Zeitschrift (1925-1926), but not as far back as E. Cartan's Paris thesis, I can see clearly in part III the prominence of the infinitesimal "subgroup" $\mathfrak{h}$ in the structure theory of infinitesimal groups which he laid out there following Lie, Engel, Cartan. (Part IV treats his character formula using integration over what we would call the compact real form of the semisimple Lie group in the background. But part III covers essentially the Lie algebra structure.) The development starts with a solvable subgroup $\mathfrak{h}$ and its "roots" in a Fitting decomposition of a general Lie algebra, followed by Cartan's criterion for semisimplicity and then the more familiar root space decomposition. Roots start out more generally as "roots" of the characteristic polynomial of a "regular" element. Jacobson follows a similar line in his 1962 book, reflecting his early visit at IAS and the lecture notes he wrote there inspired by Weyl.
In Weyl you also see an equation of the type $[h e_\alpha] = \alpha \cdot e_\alpha$, though his notation is quite variable in different places and sometimes favors lower case, sometimes upper case for similar objects. Early in the papers you see an infinitesimal group $\mathfrak{a}$ with subgroup $\mathfrak{b}$. All of which confirms my original view that H is just the letter of the alphabet following G, as often encountered in modern group theory. (No mystery.)
I always thought that $H$ did stand for Cartan—at least, for 'Henri'. However, I seem to recall that I had this discussion with Brian Conrad, and that he said it was actually Élie, not Henri, after whom the subgroups were named.
For what it's worth, the $(X, Y, H)$ convention (in preference to $(E, F, H)$) is the one to which I'm accustomed; Carter uses it, for example, in his discussion of Jacobson–Morosov triples. Embarrassingly, I don't know where the Jacobson–Morosov theorem was proven; but that's where I'd look for the history of the name.


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Gothenburg-Landvetter Airport
438 80 Landvetter, Sweden
Telefon: (031) 941 033
Website: www.swedavia.se/sv/goteborg
Gothenburg-Landvetter Airport is located 25km (15.5 miles) east of Gothenburg.
How to get there
Gothenburg-Landvetter Airport is situated just off Road 40 between Gothenburg and Borås (Gothenburg is connected to the airport by motorway). From Oslo, Malmö, Karlstad or Stockholm, follow the road signs marked with the airport symbol. When approaching Gothenburg, take the Flygplatsmotet exit for the airport.
Information about parking possibilities at the Gothenburg-Landvetter Airport
Access by public transport
Flygbussarna Airport Coaches (tel: (0771) 414 300; www.flygbussarna.se) serve Gothenburg and Borås. At peak hours they depart every 15 minutes. The journey time into Gothenburg is 40 minutes, and a single ticket costs kr80. Public buses (tel: (0771) 414 300; www.vasttrafik.se) also operate from the airport; bus 615 runs to Landvetter via Härryda Church, while bus 616 goes to Rävlanda via Hällingsjö and Landvetter. Timetables are available at Luftfarsverket Information at the airport.
Taxis are available from a number of companies, including Lerums Taxi (tel: (030) 214 600), Taxi Göteborg (tel: (031) 650 000), Taxi Kurir (tel: (031) 272 727), Taxigruppen (tel: (031) 441 441), VIP Taxi (tel: (031) 271 611) and Flygtaxi (tel: (031) 710 3000). Taxi companies often have a fixed rate fare to Gothenburg city and other destinations from the airport. Advance bookings can be made online through Takibokning (www.taxibokning.se).
Information desk
An information desk is located in the international check-in hall, open 24 hours a day. Staff at the desk can provide help and information on scheduled and charter flights, parking, hotel reservations, lost property and left luggage. Luftfartsverket Information (tel: (031) 941 100) can also be contacted in advance.
Further travel information
- Information about the city of Gothenburg
- Back to the overview


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In Illustrator CS5 when I select Scale from the Transform menu it reverts to Free Transform and I have to select it again to get Scale. Anyone else have that problem?
"Scale" from the Transform menu is a sort of all-encompassing term; once selected it lets you proportionally scale, scale in one dimension, skew, distort, rotate etc. This is usually an easier solution for most users since it means they don't have to jump back and forth between "Scale", "Rotate", etc. in the tool palette.
The "scale" tool palette option lets you scale in one direction or proportionally. If it's easier, just select the object you want to scale and hit "s" on your keyboard for the scale tool. You'll now be using just the scale (in a "scale dimensions" context).
When using Free Transform, if you only want to scale just grab one of the handles and drag it up / down / left / right / whatever. To proportionally scale (i.e. height is adjusted as width is and vice versa) hold down the shift key while scaling.


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I am a cadet at the US Coast Guard Academy and am a Civil Engineering major. I'm determined to stick to this major, but I'm struggling to keep my GPA above 2.0. However, I've noticed that the more that I think about how much harder I should work and study, the more lazy I feel. Another example is that we get a car loan of 36k at the end of my junior year, and the more I think about it, the less I feel like working to earn it. I'm normally a very lazy person, but when I start working on something, I won't stop until I finish. I've even completely skipped dinner because I was obsessed with finishing something once. So, I was wandering if this behavior is a sign of anything, if its normal, and if there's anything I can do to correct my laziness.
Procrastination is the mechanism used for coping with the anxiety of starting a task, and thinking about that elevates anticipation and hence anxiety, and in turn triggers more procrastination. When you are actively working on something you are focused on short-term goals and receiving short-term rewards, so no anxiety.
The classic solution is to break up your big goals into little tasks, so that you can focus on small tasks without getting anxious about big goals, keeping in mind not to over-do it lest you lose sight of the bigger goal. It's up to you how you want to go about this, personally I recommend personal kanban.
I've always found that it's easy for me to think of the thing I want to achieve, the end result - but find it very difficult to figure out the steps (the small steps) that I need to get there.
For the last 6-12 months I've started working out the smallest steps I can think of (or learn from someone else) to get to my goal. Half the time I realize I don't really want to do the thing when I see all the steps involved, which is great as I don't keep thinking "I wish I would do this", and half the time I have a task list of simple steps to take every day to get there....and then I just start doing the little things and tracking them. I've accomplished more with this approach in a year than in the past 10 - just a little more work ahead of time!
I used to have this feeling. It's like you're in the marathon. You need a break.
I think that should do it.


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In Ubuntu, once a release is out the software one has installed receives security updates only. In Windows, I can get new versions of programs with new features. How can Windows do this and why can't Ubuntu?
This is a problem that the Ubuntu Software Center team is in the progress of solving.
The problem is that Ubuntu traditionally draws most of its applications from the in-development branch of Debian GNU/Linux—another free operating system—and then "freezes" a snapshot of it for inclusion in a release. This body of community-maintained software—called "the universe"—consists of 80,000 software packages; Ubuntu developers couldn't possibly provide major updates for all this software, on every supported release, while still maintaining the same level of quality.
In order to resolve this issue, Ubuntu has created the MyApps developer portal. Now that Ubuntu is a large platform with over twenty million users, it is hoped that developers will be interested in submitting apps directly to Ubuntu, and release periodic updates to their software across Ubuntu releases.
For "the universe"—which the Software Center team hopes to eventually be a small fraction of available software—the "backports" system of optional software upgrades (which already exists at a half-functional level) will be scaled up.
The Software Center interface for major software updates has been designed by a Canonical UI employee, but is not yet implemented:
If you are interested in the future of application delivery in Ubuntu, I recommend watching Ubuntu Software Center and the Future of the Universe.
This is actually a feature of Ubuntu.
There is no problem with updating the software with its latest version, and Ubuntu developers might do it easily. And, actually, it is done in several other Linux distributions, including Arch.
As you have noticed, Ubuntu software is updated only with security updates and critical bug fixes. All features are "frozen", and after a Ubuntu release no software is updated to a new major version. Although it seems like a disadvantage of Ubuntu, in fact it's one of its pros.
Why freeze applications' versions and not update the features? There are several reasons.
All of the above are one of the main parts of Ubuntu quality. You get the best quality software and OS, and to balance it out you use not the newest, but just a few months older software.
Also, remember that when you update to a newer Ubuntu release, all software is again in the newest version (but stays at it until the next release), so it's not a major issue that the software does not contain the newest features. And as others suggest, you can use PPAs to fetch newer software from other sources, if you need to.
Canonical (the main sponsors behind ubuntu) decided from the start (v4) that Ubuntu will be distributed on a 6 month cycle. Every 6 months, the latest/most stable software would be included in the repositories mainly from the unstable/testing branch of debian.
Outside that cycle you could get the most cutting edge software by compiling software or including additional repositories called PPAs - personal package archives.
Windows has decided on a different strategy - new features are often (but not always) released with service packs. It gets worse under windows - it is left to individual software vendors to decide if their software should be automatically updated or not. IMHO - its a messy strategy and I have often had to rebuild windows due to rogue updates by one software or another.
Other linux distros have different release strategies. For example, you could use a rolling-release distro such as Arch. As and when newer software is released, the maintainers push out the software into their repositories if it is deemed of good enough quality. Potentially this could lead to potential conflicts between different software since not a full testing suite would have been done. In practise, the maintainers have done a good job and stability issues I've read are rarely an issue.
Debian has taken the other route - constantly refining and using a distro based on the most stable packages. Often much older than in distros such as Ubuntu.
Thus - its for you to decide - (mostly) stability or potential unstability.
Ubuntu follows a standard release cycle such that software is well tested and stable between releases, and you go from one release to the other by upgrading. On the other hand there are distributions that use a rolling release cycle, where packages are continuously updated (most famous are Gentoo, Arch Linux).
Since you're comparing with Windows, I'm too far out of date, so you can answer that part yourself I hope. I haven't used that OS in a decade.
short answer: it can
long answer: it doesn't by default, in order to provide stability
i use pinning and aptitude to pick and choose what versions to install, giving me a mix of stability and up-to-date-ness.
Ubuntu's update manager works really well by updating not only security fixes but newer versions of software and bug fixes available to packages in the repository, this means updates are tried and tested, known to work and NOT break a system with a newer untested version...
If you DO want the newer version then look for and add the repository for say getdeb.net or another source and it will update your package/program to the newest release...
Ubuntu can do this as well, but it has different policy. You can use Arch Linux where every single package is updated, but this can force you sometimes to do some things manually, because of limitations in Pacman (Arch package manager).
I have to disagree with the blanket statement in the question.
"New Feature" packages are occasionally provided mid-release, sometimes more often than I'd like in my professional capacity.
For example, Canonical upgraded CUPS from 1.4.4 to 1.5.0 as a package upgrade to the Ubuntu 11.10 release. While the basic functionality appears to be identical so far, quite a few of the defaults are different and have required modification to our configuration set prior to deployment.
By default Ubuntu offers security and recommended updates. A User can if they wish run "software sources" and select the updates tab. I usually check the box for unsupported updates (oneiric-backports) which gets me me some newer releases. There is also a check box for Pre-released updates that would expose you to more but occasionally less stable updates. You can also add ppa's for development streams of applications you're interested in. I've added the ppa for gimp which takes me past the gimp 2.6 release to the 2.7 development stream that has some new features that are important to me. Once a ppa is added updates will occur as if they were part of the supported release. This gives me considerable control over stability vs features.
Ubuntu can do what ever they want. Windows can't.
In my view there are too many. I have security only selected and out of the 47 pending, very few seem to be "security" issues. Most are new features. I like what I have so I don't believe I need new features. Aren't new features prone to have security risks?


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Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine. When chronic kidney disease reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can build up in your body.
In the early stages of chronic kidney disease, you may have few signs or symptoms. Chronic kidney disease may not become apparent until your kidney function is significantly impaired.
Treatment for chronic kidney disease focuses on slowing the progression of the kidney damage, usually by controlling the underlying cause. Chronic kidney disease can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or a kidney transplant.
Signs and symptoms of chronic kidney disease develop over time if kidney damage progresses slowly. Signs and symptoms of kidney disease may include:
Signs and symptoms of kidney disease are often nonspecific, meaning they can also be caused by other illnesses. And because your kidneys are highly adaptable and able to compensate for lost function, signs and symptoms may not appear until irreversible damage has occurred.
Make an appointment with your doctor if you have any signs or symptoms of kidney disease.
If you have a medical condition that increases your risk of chronic kidney disease, your doctor is likely to monitor your blood pressure and kidney function with urine and blood tests during regular office visits. Ask your doctor whether these tests are necessary for you.
Chronic kidney disease occurs when a disease or condition impairs kidney function, causing kidney damage to worsen over several months or years.
Diseases and conditions that commonly cause chronic kidney disease include:
Factors that may increase your risk of chronic kidney disease include:
Chronic kidney disease can affect almost every part of your body. Potential complications may include:
You'll likely start by seeing your primary care doctor if you have signs or symptoms of kidney disease. If lab tests reveal you have kidney damage, you may be referred to a doctor who specializes in kidney problems (nephrologist).
To get ready for your appointment, ask if there's anything you need to do ahead of time, such as limit your diet. Then make a list of:
Take a family member or friend along, if possible. Sometimes it can be hard to remember all the information, and a relative or friend may hear something that you missed or forgot.
For chronic kidney disease, some basic questions to ask your doctor include:
Don't hesitate to ask additional questions during your appointment.
To determine whether you have chronic kidney disease, you may need tests and procedures such as:
Depending on the underlying cause, some types of kidney disease can be treated. Often, though, chronic kidney disease has no cure. In general, treatment consists of measures to help control signs and symptoms, reduce complications, and slow progression of the disease. If your kidneys become severely damaged, you may need treatment for end-stage kidney disease.
Your doctor will work to slow or control the cause of your kidney disease. Treatment options vary, depending on the cause. But kidney damage can continue to worsen even when an underlying condition, such as high blood pressure, has been controlled.
Kidney disease complications can be controlled to make you more comfortable. Treatments may include:
If your kidneys can't keep up with waste and fluid clearance on their own and you develop complete or near-complete kidney failure, you have end-stage kidney disease. At that point, dialysis or a kidney transplant is needed.
For some who choose not to have dialysis or a kidney transplant, a third option is to treat your kidney failure with conservative measures. However, once you have complete kidney failure, your life expectancy generally would be only a few weeks.
As part of your treatment for chronic kidney disease, your doctor may recommend a special diet to help support your kidneys and limit the work they must do. Ask your doctor for a referral to a dietitian who can analyze your current diet and suggest ways to make your diet easier on your kidneys.
Depending on your situation, kidney function and overall health, your dietitian may recommend that you:
Receiving a diagnosis of chronic kidney disease can be worrisome. You may be concerned about what your diagnosis means for your future health. To help you cope with your feelings, consider trying to:
To reduce your risk of chronic kidney disease:
Original article: http://www.mayoclinic.org/diseases-conditions/kidney-disease/basics/treatment/con-20026778
Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.


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I used to be able to, but for some reason all my Facebook Javascript API calls using FB.ui() no longer work in my development environment where my url is localhost:8080. In production it works fine though. I have a dev environment Facebook application, but I did just change URLs around in it. I assume that's where the problem is. How do I have a Facebook application that allows FB.ui() calls from dev and production environments? This is the error I get when calling FB.UI() in dev:
An error occurred with AppleTree dev. Please try again later.
API Error Code: 191
API Error Description: The specified URL is not owned by the application
Error Message: redirect_uri is not owned by the application.


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You Can Shop At Amazon and Help Support Emergency-Preps.com Without It Costing You One Thin Dime - Click Here to Learn How!
0 Members and 1 Guest are viewing this topic.
Firing a gun with water in the barrel, however, is usually not a good thing. Some guns can handle it (Glock, for example), can - and centerfires will fire under water. But it is not recommended.
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Signs of Doom
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While we experienced the harshness of winter weather this week – snow, ice, wind, and bitter cold – I was glad to be home and pleased to have had some very constructive interactions with Nebraskans new to the First Congressional District. It's clear that most Nebraskans, like many Americans, are interested and concerned about the direction of their federal government – and hopeful for a brighter future for our nation.
On Wednesday, we traveled through blowing snow on ice-packed roads to get to Columbus, where we dialogued with constituents at a public "open house" meeting at the Columbus Area Chamber of Commerce. On Thursday, the single-digit temperatures didn't stop a large group of new constituents in Bellevue from coming to our open house at Bellevue University for a discussion of the challenges facing our country.
Both Columbus and Bellevue, along with all of Platte County and Polk County, are new parts of the "new" First District. In 2011, the Governor and the Nebraska Legislature approved congressional redistricting, a redrawing of the boundaries of our state's three congressional districts based on the results of the 2010 census. The changes became official with the new term of Congress beginning in January.
As you can see on the map, the First District, reflecting a larger eastward shift in population growth across the state, became smaller geographically and denser in population. Counties in parts of northeast and southeast Nebraska became part of the Third District (which now runs from Scottsbluff to Falls City), western Sarpy County moved from the First District to the Omaha-based Second District, and eastern Sarpy County including Bellevue, as well as Platte and Polk Counties, joined the First District
While it was difficult to part with many friends and familiar faces in the "old" district, I am committed to having a robust presence in the new communities. The meetings in Columbus and Bellevue this week were a very helpful and constructive first step in building friendships, partnerships, and open dialogue with area residents.
While the district lines have changed a bit, we're all still Nebraskans – facing the same inclement weather – who want constructive outcomes in Washington for the good for our country. I want to thank all those who came to visit me this week, braving the elements to attend our community meetings. My office looks forward to working for you and with you in the future.
View a map of the district at http://nebraskalegislature.gov/about/congress_map.php
Location, ST | website.com


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. Please
July 31, 2016, 12:27:00 AM
The Plug Computer Forum
Hardware and U-Boot firmware
A Kick-Butt Replacement Power Supply
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Topic: A Kick-Butt Replacement Power Supply (Read 14929 times)
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Posts: 25
A Kick-Butt Replacement Power Supply
March 20, 2011, 02:51:42 PM »
I decided to replace my SheevaPlug power supply before it did something bad. In the process, I decided to make some improvements. In particular, I wanted a kick-butt battery backup. The power can be kind of spotty in the winter months where I live, so I wanted something that I just don't have to worry about. What I did was combine a cheap AC adaptor from eBay with a 35 AmpHour battery through a pair of "perfect diodes". The AC adapter output voltage (19 VDC) was chosen to supply all the power if AC was present, even if the battery was being charged (~14VDC). When the AC goes away, the battery naturally takes over the load. The battery is sized so that the system can run continuously for nearly 3
at full load. Try that with one of those cheap battery backup boxes!
The combined output of the AC adapter and the battery feed into a DC-DC converter. The converter takes anything from approx 10 VDC to 24 VDC and puts out 5VDC. The wide input tolerance for the DC-DC converter takes care of all the changes in input voltage as AC comes and goes, and as the battery discharges.
I feed the 5V output of the DC-DC converter to the sheevaplug, the USB hub, and my USB hard drive. The converter is good for something like 15 Watts, so it easily handles all of that.
The overall system works great. We had a power failure last night (big rain, big winds), and the Sheevaplug didn't even notice.
I am thinking that a couple of possible enhancements would be:
Add another diode input (not necessarily a perfect diode, but maybe just a Schottky) for use as a solar input. A solar panel of the right output voltage would supply the power when the sun shines, and the AC adaptor would take over otherwise.
Add another DC-DC converter to give me 12VDC as well as 5VDC. That would let me power up my network devices (router, access point, DSL modem) so I could have internet during a power failure.
Anything else you can think of? Let me know. I sort of feel like adding an Arduino to it as well, just so that the Arduino can track what is going on to the power inputs and make it available to the Sheevaplug.
For a more complete write-up, see:
Full Member
Karma: 1
Posts: 129
Re: A Kick-Butt Replacement Power Supply
Reply #1 on:
March 20, 2011, 04:22:12 PM »
not going to help much here but just wanted to say..
Grrrr...why is it that some people always managed to make me feel inadequate
This kind of project is exactly what I would love to do with my Guruplug.
I shall be following your blog and this thread
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #2 on:
April 17, 2011, 06:42:07 PM »
I just sent out the new V2.0 version to fab. The improvements:
Added a dedicated input for a solar panel to feed the DC-DC converters
Adds a +12V output to provide backup power to a network router, switch, and DSL modem
Added an Arduino CPU for local intellegence; it connects to Sheevaplug via USB
4-line LCD display connected to the Arduino
Ability for the Arduino to measure the voltage on all 3 power inputs plus the input to the DC-DC converter. That's what the LCD is for, or the Arduino can report the voltages to the SheevaPlug)
Ability of the Sheevaplug/Arduino to switch the AC mains input on/off and force the system to run off battery/solar
Hmmm. The sheevaplug could send messages to the Arduino to be displayed on the LCD, too. That might be handy...
Anyway, the parts are ordered. With luck, it should be up 2-3 weekends from now...
Full Member
Karma: 1
Posts: 129
Re: A Kick-Butt Replacement Power Supply
Reply #3 on:
April 17, 2011, 06:55:32 PM »
When you say you send it to fab. DO you mean that you use an company to create the PCB?
Do you have recommendation? what is the cost for that card ?
I am connecting so many things to my guruplug that it might be usefull to start thinking about a better power
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #4 on:
April 17, 2011, 09:02:24 PM »
Making PC boards is easy these days. I use Cadsoft Eagle to design the circuit schematic, and then to lay out the actual circuit board itself. Eagle works really well, and they even have a free version. When you are done with the design, you double check it with a program like Viewmate, and then you send the appropriate files electronically to a PCB fab house. Depending on the fabricator, they Fedex you back circuit boards 1-5 days later. Totally awesome -- there is no excuse anymore for doing an electronic project any other way.
I use Alberta Printed Circuits
. They are cheap, fast and seem to produce really high-quality boards.
For really small quantities (like this new board: I only made 2 for testing until I know the design is good), it ends up around $60 per board, including fedex charges. If you make more, the price goes down pretty fast.
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #5 on:
April 28, 2011, 09:18:03 PM »
Latest update: the new boards are back, mostly built up, and seem to work fine. Here is a picture:
The most obvious feature is the LCD display. It tells me the voltage of the various power inputs, as well as the voltage that is going to the DC-DC converters. The DC-DC converter always takes its power from the highest voltage input source, so it is easy to tell which input is supplying the power.
I still have to write some software for the SheevaPower CPU. I want the SheevaPower board to be able to respond to queries from the SheevaPlug over the USB connection so that the SheevaPlug can find out where it's power is coming from. From that, the SheevaPlug can decide if there is a power failure in progress or not, or if the sun is out, or other things like that.
More details at:
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #6 on:
June 06, 2011, 10:39:31 PM »
The new power supply is working down under the house. Software written (
), parts mounted on plywood and screwed to the wall.
The next step is to get the Sheevaplug to serve a webpage that replicates the info on the LCD, and lets me control something. Not sure what yet, but something needs to be controlled, I'm sure.
Here is a pic of the new unit in action:
The full story is here:
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #7 on:
June 11, 2011, 10:48:27 PM »
The SheevaPlug power supply interface is now web-enabled, courtesy of the SheevaPlug itself:
The webpage is served by the SheevaPlug.
I also figured out how to do CGI scripts so that webpage forms can be used to issue commands to the power supply through the SheevaPlug. At the moment, the only thing I have hooked up is the ability to turn an LED on or off (and a beautiful emerald green one, at that), but even that simple thing proves that I can get my Sheevaplug to control peripherals remotely via the web.
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Posts: 129
Re: A Kick-Butt Replacement Power Supply
Reply #8 on:
June 12, 2011, 07:18:34 AM »
Congratulation on your work. This is quite amazing what you have done
Did you do a cost estimate of the all project? I am really interested to have one of these board for myself
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Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #9 on:
June 12, 2011, 04:27:35 PM »
OK, I figured it out. Short story is about $260, assuming that you had to buy absolutely every single part, quantity 1. Also assumes you can assemble it yourself.
Details are here:
But never put a price tag on a hobby. The whole point of a hobby is to allow you to justify spending money on whatever you feel like.
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Posts: 129
Re: A Kick-Butt Replacement Power Supply
Reply #10 on:
June 12, 2011, 05:25:29 PM »
Thanks a lot for taking the time to price it all.
As you say a hobby was invented by men to avoid avoid having money in their pockets which causes damages to the pockets and eventually
upset the Mrs. So really it is for the good cause
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #11 on:
July 04, 2011, 07:40:50 AM »
A holiday weekend means time for a major firmware upgrade. The biggest new feature is virtual LCD displays.
The virtual display mechanism implements a frame buffer for each virtual display, and the real hardware LCD serves to display the 'active' frame buffer. It is simple, but it effectively gives me tons more LCD real estate. Pressing the front panel button button cycles through the available displays. Right now, I have 3 virtual displays: the main one for the power supply status, another for a digital clock (all embedded projects get a clock), and one for use by the sheevaplug. The last one is the one I have wanted for a long time. It means that the sheevaplug can send messages that it would like to display on the LCD. I mean, I like the headless design and all, but sometimes it's just nice to have an output mechanism. It's trivial to add new virtual displays, so if I think of anything new it's easy to just do it.
Control of the virtual displays are also built into the command processing language. That means that the sheevaplug can write messages to its frame buffer, but if something important happens, it can send its own display to the 'front' of the LCD.
The digital clock uses the 'big digit' firmware for readability across the room. It implements a simple command language to allow the sheevaplug to read and set the time.
Next up is to figure out what I want the sheevaplug to display.
Karma: 5
Posts: 25
Re: A Kick-Butt Replacement Power Supply
Reply #12 on:
July 05, 2011, 04:20:25 PM »
I wrote a simple cron script that does two things: updates the LCD display with current info about disk usage and uptime, and sets the clock. I have the cron job run once a minute. Setting the clock that often is overkill, but what do I care? If the SheevaPower clock ever goes wrong (like when it switches to/from daylight savings), it will be right again within a minute. The other argument is that the power supply processor is clocked from a ceramic resonator, not a crystal, meaning the clock is not as accurately calibrated as it might be over a long period. Over a minute, I will never notice.
Here is the display as driven by the SheevaPlug:
The complete story is at
I have a couple friends bugging me for copies of the board. I was thinking that it might we worth swapping out the CPU for a slightly larger one with a few more IO lines. I read about an ATMEGA32U where the USB is built-in. That would let me dump the FT232 USB chip and simplify the board a little bit. Maybe I'll do that some day.
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Karma: 1
Posts: 129
Re: A Kick-Butt Replacement Power Supply
Reply #13 on:
July 05, 2011, 05:50:54 PM »
I would not mind being added to the list of people bugging for a copy of the board
At the moment Canadian Tire is selling a solar panel to charge battery at around $15 for 12v/1W
I guess that is enough to make sure that the battery will stay charged for when you need it
Full Member
Karma: 0
Posts: 131
Re: A Kick-Butt Replacement Power Supply
Reply #14 on:
August 21, 2011, 09:11:50 AM »
Very cool unit. As for a CPU to use, look into the "Teensy++", it's an Atmega that has native USB, mounted on a DIP40 sized PCB for easy connecting. Has oodles of IO. And it's really cheap.
I haven't read through your blog to see the fine details yet, but definitely will later. Are there enough details there to create one of these myself? I've got my Sheeva/External HDD/Cable Modem/Router all hooked to a small UPS with a large battery (well, 18ah), and I've always wanted to take the DC-AC part out of the loop, and just do a DC-DC like you've done. Do you have battery voltage feedback into the Sheeva so that you can do a controlled powerdown when the battery finally runs down?
SheevaPlug - 8gb class 4 SDHC primary drive, 4tb 3.5" media drive, Debian Wheezy, nginx, Samba, Shorewall
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text:
WACO (November 12, 2012)--On Tuesday, one of two autographed Werner Ladders used to hang the Baylor Bears' championship banner will be donated to Mission Waco to auction off.
The ladders were donated to both the men and women's basketball team so that the national champions could cut down the nets.
Baylor's Lady Bears will donate their autographed ladder to Mission Waco which works to help the poor and homeless in the Waco area.
During the Lady Bears' game against Kentucky, the team will hang their championship banner and the ladder will be donated to be sold at a silent auction beginning Wednesday.
The highest bidder will receive the item at Mission Waco's banquet February 5.
The Baylor Lady Bears won the championship after their 40-0 run.
To put in a bid, call Mission Waco at (254) 753-4900.


text:
Naugatuck Thanks to many for storm cleanup
I want to thank Naugatuck Mayor Robert A. Mezzo for his phone messages keeping the public informed of the clearing of streets and storm problems.
I want to thank Middlebury First Selectman Edward B. St. John and the town's Public Works Department of Middlebury for helping clear the streets on the Middlebury line.
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text:
The seven mashkim are blood, water, milk, honey, wine, oil, and dew. What is the difference between water and dew? Isn't dew a type of water?
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- Anybody can ask a question
- Anybody can answer
- The best answers are voted up and rise to the top
True, but it's not visible beforehand like water. If dew weren't listed separately, we might think that it doesn't count, because it just condensed from the air rather than actually "falling" on the food.
Besides, even water (or the other liquids) don't always make the food they touch muchshar (susceptible to tum'ah). Much of Maseches Machshirin discusses cases where water falls off something "shelo leratzon" (as an unintended side-effect of some other activity - one example is shaking a tree to knock off fruit, and meanwhile shaking water off it too), and if that water touches food, then that food still can't become tamei.
So the point of listing dew separately may be to inform us that even though it comes onto the food without human intervention (and, as above, seemingly from nowhere), yet as long as you wanted it to happen (e.g., you left fruit outside intending for it to become dewy so it'll stay fresh), then it is now muchshar.
There is water from rainfall and wells, and then there is water that has condensed from vapor in the air. The former is one kind of water, and the latter is a different kind, halachically speaking. The fact that they are chemically identical doesn't make them halachically identical.
For example, if one were to synthesize grape juice using chemicals and proteins, it would not be halachically considered wine. You couldn't make kiddush on it. See Ritva Pesachim 24b on Ta'am K'Ikar and Steipler's essay there, where a similar concept is explained regarding the taste of prohibited food. There are similar discussions regarding the cow that was created magically (Sanhedrin) or other meats occurring non-naturally, whether it is halachically meat, although chemically the two are identical.
A better question would be (and maybe this is what you meant), why is dew that condensed from water vapor in the air, different from rain which also condensed from water vapor in the air?
One could also ask, why is water from wells different from rain (as is obvious from laws of Mikvaos), isn't rainfall the original source of all well-water?
Once again, the answer is separating the halachic from the scientific. Halachah will consider well water different from rain water, and dew from rain, despite the fact that scientifically all water went through the same chemical process of vaporization and condensation.
Yerushalmi Terumot 11:2 states:
His answer seems to be that they are the same thing, but they were listed seperately to emphasize the completeness of the listing, lest someone think that something which is not on the list but is similar (such as date honey) should really be included.


text:
Wednesday, 30 May 2007
The power of a light touch on the arm
A second study involved three male research assistants approaching 240 women in the street and asking them for their phone numbers. Among those 120 women who the researchers touched lightly on the arm, 19 per cent agreed to share their number, compared with 10 per cent of the women with whom no physical contact was made.
Guegen says that when men make this light touch on the women's arms, they are perceived as more dominant which is an attractive trait associated with status.
To test this, more women were asked for their phone numbers in the street. Again, half were touched on the arm and half were not. After the male researchers had done their bit, a female researcher approached the women and asked them questions about the men. Supporting Guegen's explanation, the women who had been touched on the arm tended to rate the male researcher who had approached them as more attractive and more dominant.
This study was conducted in France, and Guegen cautioned the findings might not translate to other cultures. "It is possible that in a non-contact culture, the effect of touch in a courtship relation would be perceived negatively by women," he said.
This is not the first time psychological research has revealed the social effects of physical touch. Other studies have shown, for example, that when observers view a picture of one person touching another, they perceive the "toucher" to be more dominant than the "touchee". Yet another study found waiters and waitresses who touched customers lightly on the arm, were perceived more positively than those who made no physical contact.
Guegen, N. (2007). Courtship compliance: The effect of touch on women's behaviour. Social Influence, 2, 81-97.
Post written by Christian Jarrett (@psych_writer) for the BPS Research Digest.
22 comments:
- Anonymous7:03 pm
I dont think that it is the status that attracts women but feeling accepted and comfartable around this person. because if you compare a very good looking guy with a a moderate good looking guy women will always look at the last one because they think that the first one wil leave them but the other one will stay with them.ReplyDelete
I partially agree with anonymous.ReplyDelete
The results of the experiment could be due to dominance, but also believe that touching someone weakly can create a feeling of acceptance and confidence. Women usually have no confidence in strange men, they need to have more than superficially knowledge. That is what a weak touch can realize.
I do think it may have something to do with dominance, it would be interesting to see the study repeated but with both genders switched and then again with same sex interactions.ReplyDelete
I do agree though that it may be largely cultural, the report talks about how it may not work in a non-touch culture, but the same goes for cultures that are very tactile where the touch may not even be noticed.
There's a lot of really interesting info here, I can't wait to start digesting it, but I did feel the need to question this study.ReplyDelete
I'd assume that it came down to the individual as to whether you give them your telephone number and how they feel about being touched by a stranger. I don't enjoy people I've never met coming into my "personal space", let alone placing their hand on me.
I'd imagine that if anything, confidence would hold the majority of the persuading factor. You'd be more willing to trust someone that has confidence that someone that isn't entirely sure of themselves.
Have a Great Day
- Anonymous2:17 pm
If they did this survey in America you can be sure they would have been arrested for sexual harassment.ReplyDelete
The numbers quoted in the study do not seem convincing. 65 vs 43? 19 vs 10? Can it be established that this isn't mere co-incidence?ReplyDelete
I cannot access the full article, so my apologies if this point has already been addressed.
- Anonymous7:23 pm
I would be interested in seeing more research as to why this is. Although I agree that confidence and a certain dominance definitely play a part in perception, I think the last line of the article may also reveal something farther. I would imagine that most any physical contact not perceived as hostile would lead to a state of arousal (if only slightly) and might contribute to a form of misattribution.ReplyDelete
Such results would be in effect similar to another study where people asked out over a rickety bridge were more likely to respond favorably than those asked on solid ground. Interesting nonetheless. Now to test it out (all in the name of science of course).
- Anonymous5:23 am
a light touch dispells many notions of non-acceptance...it is not acceptable in some relationships to me, though...and the patronizing arm around the shoulders is almost a kind of violence to me, but the light touch on the arm from a woman indicates that she is responding favourably or willing to conduct communication in a positive mood.ReplyDelete
I think that what the last anonymous person says is quite interesting: could we have a point by saying that, due to the virginal attributes we associate to women, their touching others is seen as good and positive and, due to the dominance attributes people think men have, men's touching women is seen as "dangerous"? If so, then it is not a matter of "touching", but of "prejudice". I also think the numbers are not quite meaningful, especially the 10-19 ones.ReplyDelete
- Anonymous5:04 pm
A power of a light touch on the arm is also important in dreams psychology...ReplyDelete
- Anonymous9:14 am
I am on this site trying to find answers. Recently a co-worker lightly touched my arm several times (just with his finger) in a short span of time during a conversation. (I am a female) I was aroused for several days. It was like he had a spell over me. It does work - I just don't know how.ReplyDelete


text:
Letter Lovers
I have fallen sick and won't be able to teach class this week. I am thus determined to make next week even better!
Learn to use pen and paper for all they're worth. Make beautiful words. We'll start with basics of using a pen, exercises in making marks on the page, and introductions to forms of italic and blackletter. In later classes we'll make our own cola pens, 3D print letters, or laser-cut a letterpress font. Would you like to help design a NoiseBridge font?
What to bring
Recommended, but not required:
- An phone/mp3/music player, headphones, and a few of your favorite songs
- A ball point pen and blank printer paper
- Any calligraphy pen, markers, ink you already have
- Clothes that you don't mind getting a little ink on, a smock, or a very steady hand.
I will have some pens and paper too, so don't sweat it if you come last minute.
Thursday Evenings at 7:00pm.
We are just getting started, so if this doesn't work for you, please contact me. Sunday afternoons were another possibility.
There will be no class on Aug 15th as it's Five Minutes of Fame)
Church classroom at Noisebridge
2169 Mission St., San Francisco, 94114 (at 18th St., near 16th St. BART station).
First time visitors should read this for getting in: Explicit directions and how to get inside
Instruction is free!
And the materials are almost free--it's a myth that you need expensive tools to make beautiful letters. We'll learn how to do it even with a ball-point pen and paper. (Many banks provide such pens for free. :) However, use of traditional pens will also be covered, and a few will be available for loan during the class.
Stan James, a longtime letter lover, current refugee from the startup world.


text:
ATLANTIC CITY, N.J. (October 29, 2012)--Hurricane Sandy is now expected to blow ashore in New Jersey or Delaware by Monday, hours earlier than previously expected.
The storm picked up some forward speed, has already washed away a part of the Atlantic City Boardwalk, and is threatening to cripple Wall Street and New York's subway system with a huge surge of seawater.
By midafternoon, the storm was 85 miles southeast of Atlantic City, its winds at 90 miles an hour.
Forecasters warned it will combine with two other weather systems to create an epic superstorm.
From Washington to Boston, subways, buses, trains and schools were shut down.
More than 7,000 flights are grounded.
The New York Stock Exchange was closed and hundreds of thousands of people are under orders to move to higher ground.
With just more than a week to go before Election Day, President Barack Obama and Mitt Romney suspended their campaigning.
After returning to the White House from Florida, Mr. Obama urged those in harm's way to "listen to what your state and local officials are saying."
With tropical storm-force winds extending almost 500 miles from the storm's center, other major cities across the Northeast also prepared to for the worst.
Maryland's governor warned that people will die in the storm.


text:
REVOLUTION SEASON TICKET HOLDER ID CARD: As a new benefit this season, each Season Ticket Holder will receive a Season Ticket Holder (STH) ID Card. Please detach this card from the back of your season ticket book and keep it in your wallet for the duration of the season. You will be eligible for the following discounts and benefits:
- Show your Season Ticket Holder ID Card to receive 15% off all purchases made at the Revolution ProShop, located next to Gillette Stadium. The discount is valid through December 31, 2013, and is valid on Revolution game days. You must present your ID Card to receive the in-store discount. No exceptions will be made. This discount cannot be combined with any other offers and is valid only for the 2013 season for Season Ticket Holders in good standing.
- Please show your ID Card at select Patriot Place retail location which offer discounts and offers to Revolution Season Ticket Holders. Please review page 11 in this guide for the complete list of participating retail locations.
2013 GAME DAY STAFF STH CUSTOMER SERVICE RECOGNITION CARD: We are excited to announce a new initiative this season to further enhance our customer service at Revolution games. Enclosed in your Season Ticket Holder packet, please find one sheet containing four Game Day Staff Customer Service Recognition Cards. We encourage you to give these recognition cards to Game Day Staff members who go above and beyond in providing first-rate customer service at Revolution games. This new program is designed to recognize and reward staff members throughout the season and anyone receiving a recognition card will be able to exchange it for a token which may be redeemed for various prizes.
After a recognition card has been given out to a staff member, our customer service team will plan to contact you to find out more about your game day experience. If you have any questions regarding this program, please contact your service representative by calling 1-877-GET-REVS or emailing firstname.lastname@example.com.


text:
The Year in Chemotherapy
Please use for reference only.
Julia Draznin Maltzman, MD
Abramson Cancer Center of the University of Pennsylvania
Last Modified: January 12, 2004
In another reflection over the past year, OncoLink news flash would like to highlight the major pharmaceutical advancements in Oncology during the calendar year 2003. There were numerous new and important advancements in drug research and development. Some of these pharmaceutical developments that have lead the Food and Drug Administration (FDA) to either give definitive approval for or a promise of special consideration for the expedient approval of certain drugs once more data are available. Most of these new drugs have already helped thousands of patients whose options were otherwise limited. What follows is an explanation of each of these new agents and how they may help patients and physicians.
I. FDA Approved in 2003
Bortezomib (Velcade, Millennium Pharmaceuticals) May 14, 2003
Bortezomib received FDA approval for the treatment of refractory Multiple Myeloma, a bone marrow cancer responsible for more than 14,000 cases each year. Bortezomib, a proteasome inhibitor, has a novel and unique mechanism of action making it different from all traditional chemotherapies currently available. The proteasome is actually a complex of many different enzymes that exist in all living cells. This complex functions to degrade other proteins that control cell cycle. By inhibiting the proteasome complex, multiple cellular processes, including those related to growth and survival of cancer cells, are disrupted.
Bortezomib was approved based primarily on the results of a large phase II trial that showed a response rate of 35%. Moreover, almost one in five patients experienced a clinical remission. The side effect profile was noted to be predictable and well tolerated. N Engl J Med 348:2609-2617, Jun 26, 2003, Of note, bortezomib is the first new treatment in over ten years to be approved for patients with Multiple Myeloma.
Gefitinib (Iressa, AstraZeneca Pharmaceuticals) May 5, 2003
Gefitinib won FDA approval for the treatment for advanced non-small cell lung cancer (NSCLC). This approval is based on the data from the IDEAL I and IDEAL II trials. These trials, while demonstrating a significant objective response rate, failed to show a survival benefit or an improvement in disease related symptoms. Currently, gefitinib is indicated as monotherapy for the treatment of patients with advanced NSCLC after failure with both platinum based and docetaxel chemotherapies. This drug will likely create a significant impact on our society at large, as lung cancer is such a prevalent disease. It is, in fact, the leading cause of cancer deaths in the United States (an estimated 157,000 in 2003).
Polifeprosan 20 with carmustine implant (Gliadel Wafer, Guiford Pharmaceuticals) February 26, 2003
The Gliadel wafer received approval from the FDA for use in newly diagnosed patients with high-grade malignant gliomas (brain cancers) as an adjunct to surgery and radiation. Despite the multimodality therapeutic approach available today, the prognosis for patients with malignant glioma remains very poor. This is largely due to the high rate of recurrence at the tumor site. This newly approved therapy is a dime size biodegradable polymer (polifeprosan 20) saturated with 7.7mg of Carmustine (BCNU), a chemotherapeutic agent usually given intravenously to treat malignant gliomas. Once the brain tumor is removed, the neurosurgeon can implant up to eight wafers into the remaining tumor bed. Once implanted in the brain, they slowly dissolve and release the chemotherapy locally.
A phase III, placebo controlled, multi-center trial of newly diagnosed malignant glioma patients won this approval. Patients in this trial were randomized into two groups - wafer and placebo. All patients received standard radiation treatment. The primary end point was survival. There was a 56% increase in median survival favoring the wafer arm. Neurosurgery 41:44-49, 1997
Tositumomab (Bexxar, GlaxoSmithKline) June 30, 2003
Patients with Non-Hodgkin's Lymphoma (NHL), whose cells express the antigen CD20 now have another FDA approved therapeutic option. Bexxar is a monoclonal antibody (tositumomab) linked to a radioactive molecule (Iodine I-131). Tositumomab is able to target and bind the CD 20 antigen on NHL cells. Once bound, the antibody delivers a dose of I-131 radiation directly to the cancerous cells. Bexxar is currently approved for follicular NHL with or without transformation, refractory to rituximab.
Approval was gained based on a single arm study in patients with low grade or transformed low grade NHL where the overall response rate was 63% with a median duration of response of 25 months. J Clin Oncol. 2000 Mar;18(6):1316-23.
Aloxi (palonosetrom, MGI Pharma) July 28, 2003 and Emend (aprepitant, Merck) April 1, 2003
Two important drugs in the management of patients with cancer gained approval during the year 2003. Aloxi (palonosetrom, MGI Pharma), a 5-HT3-receptor antagonist that is effective in preventing chemotherapy induced nausea and vomiting and Emend (aprepitant, Merck), that treats and prevents delayed onset of nausea and vomiting after chemotherapy.
II. Obtained Orphan Drug Status from the FDA in 2003
Orphan drug status is given to drugs that have the potential to treat life-threatening diseases that affect fewer than 200,000 patients in the United States. It gives the designated chemotherapeutic seven years of market monopoly in the US and provides access to potential grant funds for clinical research. Receiving this designation indicates that the FDA is committed to the advancement of the product and is trying to facilitate further research and development. In addition, orphan drugs often receive expedited reviews by the FDA in comparison to other drugs.
Theralux Photodynamic Therapy (Thera-technologies) April 2003
A Canadian biotech firm received FDA orphan drug designation for their product Theralux to treat patients with Chronic Myeloid Leukemia (CML). It is a photodynamic therapy technology being developed to destroy cancer ells in bone marrow or blood outside the body (ex-vivo). This drug selectively kills cancer cells when exposed to light. In addition to CML, this technology is also being evaluated for other malignancies including Non-Hodgkin's Lymphoma.
Rexin-G (Epeius Biotechnologies Corporation) September 8, 2003
At a time when gene therapy is a dirty phrase, FDA designated Rexin-G, the first tumor targeted injectable gene therapy vector, as an orphan drug for pancreatic cancer. This decision was based on a demonstration of medical plausibility of this product for all types of pancreatic cancer. The product is currently in phase I/II trials.
GTI-2040 (Lorus Therapeutics Inc) March 24, 2003
Orphan drug status was given to this anti-cancer agent used for advanced kidney cancer. GTI-2040 is currently in phase II clinical trials. This drug a small oligonucleotide that acts as an antisense strand and stops tumor RNA from making proteins. When cells are unable to make certain proteins, they die. In early preclinical trials, GTI-2040 has shown a high safety profile.
III. Obtained Fast Track Approval from the FDA in 2003
This designation is a promise from the FDA that it will take all appropriate actions to expedite the development and review of the application for approval of each of these products. Often, drugs that obtained a fast track approval were once designated as orphan drugs.
Advexin (Introgen Therapeutics Inc) September 17, 2003
Advexin selectively kills cancer cells by supplying the p53 protein in very high concentrations to the cancer tissue. P53 is a normal tumor suppressor that senses when a cell has been damaged or mutated and signals the cell to stop dividing and initiate repair mechanisms. If the cell is damaged beyond repair, p53 begins the cell death pathway to prevent this cell from dividing out of control. Two, phase II studies were done in patients with recurrent and unresectable cancer of the head and neck where Advexin has shown some efficacy in prolonging survival and time to local disease progression. There are currently ongoing phase III trials in head and neck cancer comparing this agent alone and in combination with conventional chemotherapy.
Revimid (CC-5013, Celgene Corporation) April 15, 2003 and February 4, 2003
Revimid is a Thalidomide analog that appears to be more active than Thalidomide but less toxic. It has been used in early clinical trials for patients with myelodysplastic syndromes (MDS) and relapsed or refractory Multiple Myeloma. MDS are five types of malignant disorders of blood cell production that eventually lead to acute leukemia. There are an estimated 300,000 people affected with MDS worldwide.
Revimid seems to target MDS and Myeloma through a number of different mechanisms including inhibition of growth factors that may feed the cancer and suppressing growth of new blood vessels into the bone marrow. Encouraging Data with Revimid in refractory Multiple Myeloma was presented at the 45th annual American Society of Hematology meeting in December 2003 in a number of phase I and II trials. Early data supporting Revimid's efficacy in MDS was presented at the annual Chemotherapy Foundation Symposium XXI in New York November 2003. These data are preliminary and should be interpreted with caution.
Xyotax (CT-2103, Cell Therapeutics Inc) June 16, 2003
Xyotax is a polyaglutamated paclitaxel that is supposed to have fewer side effects without compromise in efficacy and is targeted for NSCLC patients with poor performance status, who could not otherwise tolerate chemotherapy. Xyotax has unique polymer technology that allows it to be selectively delivered directly to the tumor in much higher concentrations. In preclinical data, higher dose of chemotherapy was noted to be delivered directly to the tumor bed as the polyaglutamated drug is trapped in the blood vessel feeding the tumor. As more chemotherapy is being delivered precisely to the cancer, the concentration of drug sensed by healthy surrounding tissues is reduced and the side effects are therefore fewer. This drug is currently in phase III clinical trials.
Satraplatin (GPC Biotech) September 22, 2003
FDA grated the fast track status for Satraplatin for second line chemotherapy for patients with hormone-refractory prostate cancer (HRPC). Satraplatin is a member of the platinum family of chemotherapeutics, but unlike other currently available platinums, Satraplatin is an oral, not an intravenous, compound. One positive result from a 50 patient trial was already reported at ASCO 2003. These data seem to indicate a significant improvement in time to disease progression. Satraplatin is currently being investigated in other cancers such as ovarian and lung cancer.


text:
27 Dec 2010 1:16 PM #11
27 Dec 2010 1:34 PM #12
this is a really nice plugin, thx for sharingFirst I would like to thank you for your time and knowledge
Win 7 Ext JS 4.1.3 IE(6-9), FF17
27 Dec 2010 3:06 PM #13
Not sure if this helps anyone, but the solution I use is to modify the style for the offending class (x-resizable-handle), this works like a dream. You want to do it in the afterrender of the image cropper to ensure the class has been rendered and therefore added.
var crop = new Ext.ux.ImageCrop({ imageUrl: imageSrc, initialWidth: imgLoad.width, initialHeight: imgLoad.height, preserveRatio: false, minWidth: 100, minHeight: 100, quadratic: false, listeners: { afterrender: function() { var domElements = Ext.DomQuery.select('#imageEditorPreview .x-resizable-handle'); for (var i = 0; i < domElements.length; i++) { var domElement = domElements[i]; var element = Ext.Element.get(domElement); element.applyStyles('opacity: 1;'); } } } });
18 Mar 2011 7:45 AM #14
Here is another way to do it
here is another approach to do so.
Demo url:http://www.developerextensions.net/i...1.2&Itemid=481Thanks
Surinder singh Mattaur (Matoo)
Extjs Excel copy/paste Grid
Extjs Photo Uploader
Extjs Filter Row
Extjs Grid Query Builder
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Extjs Form Phone Field
Sencha Cube Carousel
Sencha Date Picker
Sencha Touch Themes Builder
Joomla Component Creator
21 Mar 2011 11:07 PM #15
x1, x2, y1, y2 coordinats
I see that Croper calculate x and y coordinats only, but how to calculate x2 and y2 coordinats also?
Best regards!
12 Oct 2011 4:17 PM #16
x2 = x1 + el.getWidth()
y2 = y1 + el.getHeight()
29 Jul 2012 9:20 PM #17
Is there anyone upgrade this class to compatible with 4.1?
10 Jan 2013 9:08 AM #18
28 Jan 2013 1:09 AM #19
ExtJS 4 Version created
Hy all,
there is a new Version for Ext 4.1 out:
thank you for your patience
4 Feb 2013 4:17 AM #20
the url has a lot of problem it seems to broken i dont know how it would be going to get resolved....
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This question was originally asked by Paul Slevin, but it was deleted before I had the chance to answer. It's actually quite subtle, so I thought it would be worth reposting it here.
Consider the following proposition: $\DeclareMathOperator{\mor}{mor}$
Proposition. Let $\mathcal{C}$ be a category. If $\mathcal{C}$ has limits indexed by diagrams of size $\left| \mor \mathcal{C} \right|$, then $\mathcal{C}$ must be a preorder.
This is easy to prove when $\mathcal{C}$ is a small category: assume, for a contradiction, that there are two distinct parallel arrows $f, g : A \to B$ in $\mathcal{C}$. Since $\mathcal{C}$ has large products, there exists an object $C$ in $\mathcal{C}$ equipped with a bijection $$\textbf{Set}(\mor \mathcal{C}, \mathcal{C}(X, B)) \cong \mathcal{C}(X, C)$$ that is natural in $X$. In particular, we have $$\textbf{Set}(\mor \mathcal{C}, \mathcal{C}(A, B)) \cong \mathcal{C}(A, C) \subseteq \mor \mathcal{C}$$ but the LHS has cardinality $\ge 2^{\left| \mor \mathcal{C} \right|}$, so this contradict's Cantor's theorem on powersets.
Question. How do I adapt this proof for the case where $\mor \mathcal{C}$ is a proper class? In class–set theories such as von Neumann–Bernays–Gödel or Morse–Kelley, it doesn't make sense to talk about the collection of all subclasses of a proper class, because any member of any class is a set, and even the collection of all maps $\mor \mathcal{C} \to \mathcal{C}(X, B)$ fails to be a class.


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Members of the media who wish to reach students, faculty, staff, or a spokesperson of the College, please email Media Relations or call 802-440-4399.
Bennington College
Office of Communications
One College Drive
Bennington, VT 05201-6003
The awards recognize individuals and institutions that have made substantive contributions towards improving higher education opportunities for New England students.
The Quantum Leap program, developed in 1999 by faculty members Susan Sgorbati and Danny Michaelson, helps at-risk elementary, middle, and high school students in the community return to school. As an alternative to dropping out and being processed through the court system, these students work one on one with Bennington students and faculty to develop individualized educational plans modeled after the ones that Bennington students use to structure their studies at the College. The program aims not merely to get these students back in school so they can make it through, but to help them discover a love for learning that will allow them to prevail.
To read about some recent Quantum Leap initiatives, click here.


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Understand how consumers want to engage
The smartphone user has grown up, which in turn means that brands, enterprises, and the services they offer need to mature with them. Businesses now communicate to customers across multiple channels from many different sources within the organisation. Read the survey results to find out about consumer responses and the technologies preferred.


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Aurelo CV / Resume is a html template That Will help you set up a professional online CV in minutes. With minimalist design feel, it this very good clean design. You can easily add content and keep it within one click distance, due to the jQuery scroll Up and scroll Down plugin implemented.
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I'm currently running 12.04, my 160GB hard disk is messed up, I'm going to completely format it. Here is what I want to do:
- Keep 10 GB for 10.04 /
- Keep 10 GB for 12.04 /
- Keep 4 GB for /swap
- rest for /home.
How should I start, install 10.04 first then 12.04?, Am I missing anything? Also I read I can share my home folder between the two OS when its on another partition, will it be done by default or do I need to take some steps to do this?


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A Manicure Spot, Just For Men
Hammer & Nails is the first polish spot just for guys
RELATED: A Three-Minute Manicure Tutorial
While we admit the name had us cracking up, Elliot may have a point. Nail salons are definitely lady-specific domains, and we can imagine that men might feel a bit alienated in a typical pink-splashed manicure den. Elliot, a screenwriter by trade, who wrote that Queen Latifah movie Just Wright, said he got the idea after one too many bad manicure experiences. "I have always hated going to get a mani just because of that feeling of walking in the door and it seems like all the women kind of look at you like, 'What are you doing here?' and it's just awful."
The first Hammer & Nails opens on Melrose Avenue in Los Angeles in November. It'll feature oversized leather chairs and every guy gets his own TV and headphones. He doesn't have a liquor license just yet, but plans on offering complimentary beer and whiskey. Wait a sec, that sounds better than our nail salon.
RELATED: The Best Do-It-Yourself Pedicure Tips "I want to make nail care as common as getting a haircut and I feel like creating the right environment is key to that," said Elliot. Sign our boyfriends up. [Fashionista]
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Women's Footwear
Sandals, shoes and more from quality brands like Olukai, Reef and Ugg Australia. Look great and stay cozy on your way to check the surf.
UGG Australia Dixi Flora Perf Boots - Chestnut$149.95
Sanuk Women's Yoga Sling 2 Sandals - Black/White$35.95
Olukai Women's U'I Sandals - Rose Gold/Sahara$89.95
UGG Australia Classic Tall Boots - Grey$194.95
Sanuk Women's Yoga Joy Metallic Sandals - Rose Gold$31.95
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Roxy Women's Xalapa Sandals - Gunmetal$28.95
Sanuk Women's Yoga Sling 2 Prints Sandals - Eggshell Tile$37.95
Reef Women's Sandy Sandals - Black$27.95
UGG Australia Dakota Slippers - Dry Leaf
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Olukai Women's Kulapa Kai Leather Sandals - Black$79.95
UGG Australia Rioni Boots - Chocolate$159.95
Roxy Women's Stinson Sandals - Rose Gold$38.95
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Reef Women's We Heart Scrunch Sandals - Brown/Pink$35.95
UGG Australia Classic Tall Boots - Chocolate$194.95
UGG Australia Classic Bailey Button Boots - Grey$164.95


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(314) 577-5600
Garlic is used to season food. It's in the same plant family as onions. A head of garlic is actually a bulb that grows underground. You buy a head of garlic, which can be separated into cloves.
Garlic has a big, big taste and flavors a lot of wonderful food, including Italian, Indian, and Chinese food. Some research has shown that garlic might help keep people healthy by preventing cancer. It's unclear why this is, so more studies are being done.
A few brave souls might eat raw garlic, but usually it's cooked. Garlic can be chopped up and sauteed with meat or vegetables. It also can be added to soups and other dishes, such as spaghetti sauce. Here's a great way to try garlic: Have your mom or dad roast a few cloves in the oven. When it's cool, you can squeeze out the soft insides on a piece of bread. You can spread it like butter.
Some people love garlic. They love it so much, they have garlic festivals. You'll find garlic festivals in the United States and in Europe. If you ever go to one, you can try garlic jelly, garlic chocolate, garlic popcorn, or deep-fried garlic pickles!


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10 Apple-Themed Crafts and Activities
2 of 11
Apple Candlesticks
Apple candlesticks are easy for kids to help create and make a great seasonal centerpiece. Use your imagination to carve designs into each apple— the possibilities are endless! Just remember to leave the carving to the older kids, and always supervise your kids when using a knife.
Get the directions for Apple Candlesticks.
Next: Apple Art


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Photo Gallery > "Let's Try Some Helmets On" > Novelty "Eagle" Purple Rose
Novelty "Eagle" Purple Rose New!
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- Currently out of stock.
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Illinois State Police District 19 Commander, Captain Morrie Fraser, would like to announce the results of the 11th annual in-house Charity Auction held at the District 19 Headquarters on Friday, Nov. 30. Retired District 19 troopers and current staff, along with local businesses and vendors, donated the various items that were auctioned off. At the end of the day, a total of more than $4,500 was raised from the Charity Auction and other monetary donations.
As a result of the auction, District 19 will be able to make a $650 donation to charitable organizations already identified in each of the seven counties it serves. The donations are being made to those charitable organizations coordinating programs for underprivileged children in the area this holiday season.
"I would like to recognize and thank all those who made the 11th annual District 19 Charity Auction a success," said Captain Fraser. "If it was not for the continued generosity of those involved, these monetary donations would not have been possible. If your organization works with underprivileged children and would like to be considered for future donations, contact Sergeant Mark Zimmerman at 382-4606."
Captain Fraser would like to give special recognition to the following businesses and organizations for their donations to this year's District 19 Charity Auction: Village of Old Shawneetown, Bella Shea Beauty Salon - Carmi, Cherry Street Automotive - Carmi, CVS Pharmacy - Carmi, Logo Graphics and Gifts - Carmi, Six Shooters Guns - Carmi, Indian Creek RV - Norris City, West Farms Trucking - Norris City, Jim and Randa West - Norris City, Robert Rubenacker - McLeansboro, Robert Hastings - McLeansboro, Southern Illinois Pool - Eldorado, Dirt Busters Auto Car Wash - Harrisburg, Ponderosa - Harrisburg, Raben Tire - Harrisburg, Southern Illinois Workwear - Harrisburg, Auto Trim Mart - Harrisburg, Mitchellsville Store - Mitchellsville, Miller's Army / Navy Store - Carrier Mills, The Red Onion - Equality and The Print Shop - Sesser.
Location, ST | website.com


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Originally Posted by jhondenLink juice is the quantity of link benefits as in traffic and ranking one gains and page rank juice is the end result of such links. But link juice is related to over optimization which is gonna get stopped in few days.
Originally Posted by ozsubasiI'm not sure how you arrive at that conclusion. A "natural" link passes link juice and has nothing to do with over-optimization.
I agreed with that, the concept of link juice has nothing to do with over-optimization because if this comes into the trend then, what will be the importance of Page Rank remains in the internet. The high Page Rank referring sites are considered to be very important and trustworthy. Therefore, Page Rank is the factor of concern for most of the website owners in-spite of its percentage in the contribution of SERP ranking of a website.


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North Carolina Blast Injury Education Program
Response to an event involving an explosion requires a unique knowledge and skills set to manage effectively and efficiently. The safety concerns, injury patterns, triage and treatment characteristics and the high profile nature of these events requires the responder to be thoroughly prepared. This program is designed to educate the emergency responder in the assessment, initial management, triage, and transport of patient(s) who are involved in a blast event. This program will provide training on specifically how blast events should be managed in the North Carolina Trauma and EMS systems. This program will build on knowledge in hazardous materials and WMD that the responder has previously obtained and will use an all hazards approach to blast management so that all potential causes of an explosive event (terrorism, natural, accidental, etc.) will be covered. This short form will allow the North Carolina Burn Disaster Program to track the distribution of this program and in the future send program updates to previous program participants.


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I am trying to do something unusual (?) with Git --- storing my multimedia files and photos and some pdf files with Git. I want to keep some meta data with each file (e.g., with a photo: I want to keep some sort of caption with it; with a pdf file: some information about what the file is about for ease of searching later on). In svn you can use svn properties to store metadata about a file (I think). How do I do the same in Git? Haven't been able to find any easy way!
git notes looked promising, but it only associates notes with objects (commits). I want notes with individual files.
Update: I do not want to keep a separate file for metadata of files/paths! :-) I want to keep the information with the file/path somehow. Like svn properties (
svn propset caption "In the Golden Gate" foo.jpg). To be more precise, when I move files around (
git mv path1/file path2/file), I don't want to have to worry about keeping the metadata file up to date... the metadata should move with the file.


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Pauline Thompson, age 76, died Sunday, December 23, 2012 at Mercy Hospital in Oklahoma City, Oklahoma.
Memorial service will be held Thursday, December 27, 2012 at 2:00 PM
at the First Baptist Church in Elkhart, Kansas. Friends may call Wednesday, December 26, 2012 from 6:00 PM until 8:00 PM at the First Baptist Church in Elkhart, Kansas. Memorials may be given in lieu of flowers to the First Baptist Church for missionaries or the Morton County Libarary in care of Garnand Funeral Home, P.O. Box 854, Elkhart, KS 67950.
Location, ST | website.com


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Please enter a maximum of 5 recipients. Use ; to separate more than one email address.
The technical center offers a full range of analytical and testing capabilities in support of product and application development efforts as well as marketing and technical service for the area customers, according to Dr. Peter Frenkel, global director of technology and innovation for Galata Chemicals.
Galata Chemicals held a grand opening for its newest
technical center in Navi Mumbai, India, the company said on
Galata Chemicals is committed to investing in technology and bringing innovative
solutions to our customers in the region, said Steven
McKeown, president and chief operating officer of
Galata Chemicals.
The technical center offers a full range of analytical and
testing capabilities in support of product and application
development efforts as well as marketing and technical service
for the area customers, according to Dr. Peter Frenkel,
global director of technology and innovation for
Frenkel added that the center is focused on providing
high quality, reliable and innovative products for customers in
the India region, building on the
company's established products and technologies.
Dr. Anand P. Gokhale, an experienced scientist with a proven
record of product development and market introduction in the
field of polyvinyl chloride (PVC) additives, was named director
of research and development to coordinate technical activities
at the center.
This is another step taken to strengthen our technical
capabilities, having recently expanded our technical
center in the United States and having added
technical staff globally," said McKeown.
"The company is continuing to recruit talented scientists and
is making ongoing investments in innovative products such as
our new Mark heat stabilizers and Drapex
Alpha bio-based primary plasticizers, said McKeown.
Galata's line of plastics additives includes mixed metal heat
stabilizers, organotin heat stabilizers, epoxidized soybean
oil, polymer modifiers, tin catalysts and bio-based
All comments are subject to editorial review.
All fields are compulsory.
Yes!Power industrial cable manufacturing industries will surely benefit with this galata co., at Navi Mumbai.wish every success to Galata family in USA & india.Agurieeeeee..
I am looking forward to India that this will be the beginning of success on plastic mouldings investment.
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A searchable database of project activity in the global hydrocarbon processing industry
Engineers and designers are highly skilled individuals. Forcing them to enter design changes using tables, forms and spreadsheets is unproductive and uneconomical, and it increases the likelihood of human error—this is the way that most instrumentation software systems currently work. For too long, software vendors have denied engineers and designers the simple practicality of a graphical visual engineering interface with "drag and drop" capability and inbuilt intelligence, ensuring changes are automatically replicated into all the associated data and databases.
Is 2016 the peak for US gasoline demand?
Too soon to tell
July 2016


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I've only played some multiplayer with a friend so far.
When I right click on the ground and on enemies, and I see there is a "Focus on Zone" command (along with a corresponding "Ignore Zone" command). However, these always appear to be grayed out.
What do these commands do, and how do I activate them?


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Q&A: Tony Stewart and Saturday's crash
Authorities have said no criminal charges are imminent after a fatal racing incident where NASCAR icon Tony Stewart struck and killed sprint car driver Kevin Ward Jr.
Here are some answers to questions about the two involved in Saturday's accident.
Q: Who is Tony Stewart?
A: Stewart, 43, is one of racing's notable names. He lives in his hometown of Columbus, Indiana and competes for Stewart-Hass Racing as a driver/owner. Stewart is a three-time Sprint Cup Champion.
Q: Who is Kevin Ward Jr.?
A: Ward Jr., 20, was working to make his name in the racing scene. He was seventh in points in the 2014 Empire Super Sprints Championship Tour with two top-five finishes. He is from Port Leyden, New York according to The Associated Press and was the Empire Super Sprint Rookie of the Year in 2012.
Q: How did this happen?
A: The matter is still being investigated. Multiple outlets are reporting Ward had crashed with Stewart's car during a low-stakes race at Canandaigua Motorsports Park in upstate New York. Ward got out of his car along the fence and crossed into the racing area. Ward reportedly was struck by Stewart's car. Ward was wearing a black firesuit and black helmet.
Q: Has Stewart been in past accidents?
A: Stewart broke his leg last year in a sprint car race and only started racing again last month. Stewart also took responsibility for a 15-car accident last year where 19-year old driver Alysha Ruggles sustained a compression fracture in her back. That race also took place at Canandaigua Motorsports Park.
Q: What race was Stewart preparing for?
A: Stewart had planned to race in the NASCAR Sprint Cup Cheez-It 355 at The Glen, one of only five remaining races to score points to get a spot in NASCAR's Chase. Stewart reportedly often participates in low-stakes races.
Q: Will Stewart race in the NASCAR Sprint Cup Cheez-It 355 at The Glen?
A: No, he will not. After his team announced Stewart would proceed as planned, but according to a spokesperson Stewart "feels strongly" about not racing.
Find out more with this Newsy video.


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My Album is a place for you to organize your favorite images found on this site. Please sign in or create an account to save an image to your album.
Can't find the image you're looking for? | Information regarding non-personal use | Interested in purchasing a PDF page?
For Thomas E. Franklin's photo of "Firemen Raising the Flag at Ground Zero", visit groundzerospirit.org.
Copyright © 2016 North Jersey Media Group Inc.
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PULL OUT STYLE SHOWER MIXER - Scandvik
Features a pull out style shower assembly with a water conservation valve and adjustable spray pattern. The body is chrome plated brass. White plastic handle with chromed plastic adjustable spray nozzle and a 5' nylon hose. 3/8" BSP male and 1/2" male NPT connection. Requires a 1-1/2" mounting hole.
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Bus drivers help children
January 19, 2013
To the editor: With all the bad news lately and bad situations happening to children, I wanted to express my thoughts about our local school bus drivers and the ladies at the school who talk back......
I had that type of bus driver when I went to my schools of Stark, Hills, and Mingo. I too want to say thank you for them treating me with RESPECT.
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HEWITT (January 1, 2013)--The City of Hewitt is holding a ribbon-cutting ceremony for "Adventure Playground" Friday.
The newly completed playground was designed to bring together children of all ages and abilities with a variety of play elements.
City staff worked with local elementary schools to receive feedback on play features most enjoyable to children.
Meanwhile, The Hewitt Parks and Beautification Committee teamed up with adults with children with disabilities to determine how the whole community could participate.
The Kiwanis Club of Waco, Inc. provided financial support in memory of Chuck Slough.
The new playground is located at Hewitt Park on Hewitt Drive and includes a signature red shade seen from the street.
The ceremony will begin at 10 a.m. with the Boy Scouts from Troop 377 to lead the Pledge of Allegiance.
A commemorative "I was there first" flying disc will be available for the first 250 people in attendance.


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I must say that my NN3 has opened up so many creative possibilities. What I am working on mainly is creating HDR panos in different locations and then shooting people in the studio, matching the light and creating massive images. I am a pixel pig!
I am using a Nikon D300 with a Tokina 11-16mm lens for the HDR panos and then a Hasselblad H1 with a imacon 96c digi back for the models. Looking forward to ordering the new NN5 that can support the Blad. For some samples please visit http://gallery.me.com/grahamtwomey#1...lack&view=grid


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Where is the church?
March 3, 2013
To the editor: Before the start of the Revolutionary War, Samuel Adams once said, "We do not require a majority to prevail, but rather an irate tireless minority to set brush fires in peoples mind....
With only now 33% of the US pop now attenting church regularly (the rest---The lost generations of the last 40 yrs. who see themselves as the center of theuniverse)It is getting more difficult to teach ay type of morality. If youth are not being taught by parents, community, teachers, and they don't even attend churches any more, The kids of now and I would say since the 70's just care about themselves and their "comfort zone." Fearful of where we are going as we become more Godless as has Europe, Asia, S America. The secularists/atheists seem to be winning the battle here. It frightens me to no end, it is where this country went off the rails, though the self-absorbed could never take the time to see that.
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Hollow Base Cleat 4-1/2" SeaDog Line
This item is found in the following Product Families
Seadog Hollow Base Cleat
Die cast zinc chrome plated. Bases are drilled and countersunk for #8 and #10 fasteners. Skin packed on attractive card.
This product ships in 1 business day.
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Do I need a foundation for this type of shed, or can I just put it on level ground?
The assembly instructions state:
So it should be installed on a level platform of some kind that will support the weight of the shed and its contents.
It wouldn't be a good idea just to use level ground as you'll have problems with moisture, rodents etc (as Eric Petroelje points out in his comment). You may well also find that the shed will sink unevenly into the ground making it difficult, if not impossible to use.
I got pea gravel and spread it onto bare ground after I raked it. I have had my shed for 4 years. It is not sinking. YMMV but I don't think you need to lay a concrete surface. On older, wood sheds it was recommended due to rot, but in a Rubbermaid shed I don't think it is necessary.


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The holiday spirit will shine brightly in communities throughout our area as residents welcome the holiday season with their annual light-up nights.
Streets throughout the Tri-State Area again will twinkle and glow, and children once again will have the opportunity to experience a little piece of holiday magic.
Toronto's light-up night is scheduled for 6:30 p.m. Tuesday at the city's gazebo commons. A highlight of the evening will be the memorial luminaria. Proceeds from the sale of the lights will benefit the Salvation Army's home heating assistance program organizers said.
The evening will include Christmas carols and, of course, the lighting of the city's tree.
Wellsburg, meanwhile, plans to hold its light-up night Friday, after the community's annual Christmas parade.
And, Mingo Junction will come alive next Monday when it holds its annual light-up night. The event will feature performances from the Indian Creek High School band and children from Hills Elementary School.
There will be treat bags for children and doughnuts, hot chocolate and coffee, with the village's tree being donated through personal contributions of members of village council.
Sadly missing from this year's lineup of light-up nights is Steubenville, which revived its annual event in 2006.
Light-up nights are enjoyable events that bring communities together.
They help foster a joy and excitement for the coming season.
We hope you will be a a part of the festivities in one or more of our area's communities.