text:
"The Leonardo da Vinci of data." THE NEW YORK TIMES
Fundamental design strategies for all information
displays: sentences, tables, diagrams, maps, charts,
images, video, data visualizations, and randomized
displays for making graphical statistical inferences.
New ideas on spectatorship, consuming reports.
How to assess the credibility of a presentation
and its presenter, how to detect cherry-picking,
how to reason about alternative explanations.
Standards of comparison for workaday and for cutting
edge visualizations. How to identify excellent
information architectures and use them as models and
comparison sets for your own work and for the work
of your contractors. Monitoring the designs of others.
The future of information displays: 4K, 6K, 8K video
maps moving in time.
Practical examples are from everywhere: science, social
science, music, business, finance, sports, art, medicine,
architecture, NASA, government reports.
The entire course is taught by Edward Tufte.
For full-time teaching faculty, students, postdocs, the
fee is $220. To register, follow the instructions online
and document your status with the following information:
(1) Image of your current student, faculty, postdoc ID
(2) A direct phone number of a registrar or department
office that can verify your status, or a direct link to an
institutional website that shows your position.
There are no other discounts.
Graphics Press federal tax ID number: 06-1637582
Groups can use the
group registration form
or fax, mail or firstname.lastname@example.com.
For full-time teaching faculty, students, postdocs only:
Online Registration Faculty/Students/Postdocs.


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Showing 1-53 of 53 items found in Food & Drink
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Downtown Rock Island Arts & Entertainment District
This district is the arts and entertainment destination of the Quad Cities. Located on the Mississippi River, the district ia a revitalized and vibrant area. You'll find art galleries, restaurants, pubs, nightclubs, casino, shops and a hotel.
CITY:Rock Island
Jumer's Casino & Hotel - Rock Island
Jumer's Casino & Hotel is one of the largest land-based casinos in the state of Illinois. Jumer's is where Art Deco meets 21st Century gaming. The all on one level casino floor features the latest in gaming fun. Over 1,000 slots, 25 table games, and a live Poker Room. In addition, you will enjoy a night club, sports bar, and four distinct restaurants featuring everything from steak and seafood, to outstanding buffets, and deli-style menus. The luxurious hotel offers 205 hotel rooms, an indoor pool, fitness center, and a full-service Spa. We're the perfect place for leisure travel and for meetings, conventions, parties, or banquets. Our luxurious hotel has all the modern amenities guests expect. Oh! What a feeling! You are going to love the new Jumer's Casino & Hotel.
CITY:Rock Island
The Speakeasy
Enjoy comedians, big bands, burlesque, drag shows, and more at the Speakeasy. This intimate club offers live performances throughout the year to fit a variety of tastes. The Speakeasy features a bar, simple menu, and performance seating at small and large tables. To see what's coming up next at the Speakeasy visit http://circa21.com/speakeasy.asp
CITY:Rock Island
Creekside Vineyards Wine Terrace & Inn
Enjoy this vineyard and B&B combo located just a few minutes from major attractions in the Quad Cities. Vineyard tours are available by appointment. Lovely Inn located in a beautiful country setting, yet minutes from entertainment, dining and shopping. Wine tastings offered throughout the year. Check website for complete details on wine tastings, special events, and to book a room at the Inn.
CITY:Coal Valley
Blue Cat Brew Pub
Enjoy this micro brewery and restaurant situated in the downtown Rock Island Arts & Entertainment District. The Blue Cat Brew Pub is a locally owned establishment that creates fine food and handcrafted ales and lagers for first hand sampling. Menu features homemade recipes and specials. A place to meet - friends, family, business partners, and whatever combination there may be. A place where the staff love to meet people and make new friends from around the country. Shoot some pool, throw some darts, or just hang out and relax.
CITY:Rock Island
Bent River Brewing Company
Bent River Breweries in Rock Island serves as the distribution center for Bent River, including a bottling line so the beer can get to the people. This location also includes a tasting room with full bar, an expanded merchandise room, a party room for catered banquets, and great live music.
Circa '21 Dinner Playhouse
Discover the beautifully restored, historic Vaudeville-Era Dinner Playhouse. Circa '21 services up exciting musical productions with dinner. Even your wait staff are part of the pre-show! Watch your waiter dance, and sing before each show begins. Matinee performances are also available. Check website for current show schedule.
Lavender Crest Winery
Lavender Crest Winery opened its doors for the first time in November of 2004, introducing customers to an opportunity for a unique way to taste wine that is produced in the Midwest. Lavender Crest Winery features a wine tasting room, gift shop, an espresso bar that serves lunch, entertainment, tours and more.
The Bier Stube
German Restaurant with a large German menu and beer selection. Enjoy the outdoor Beer Garden and live music on weekends.
La Flama
Family-owned restaurant featuing homemade Mexican cuisine in a festive atmosphere with plenty of seating and parking nearby. A full bar is available at the restaurant and features delicious, traditional drinks.
Happy Joe's Pizza & Ice Cream Parlor - Quad Cities
Original pizza parlor started in the Quad Cities featuring the first Taco Pizza, along with dozens of topping choices that will suit the tastes of all its customers. Also, enjoy the pizza and pasta bars available at select locations. Dine in or have this delicious pizza delivered to your hotel.
Theo's Java Club
Coffee house with deli sandwiches, pastries, soups and light fare. Located in the heart of the Downtown Rock Island Arts & Entertainment District.
CITY:Rock Island
John Deere Commons at Moline Centre
A tourism destination offering a variety of restaurants, concerts, special events, top name entertainment at "iWireless Center," and live music at the many pubs and bars. Also visit the famous John Deere Pavilion and John Deere Store, Lagomarcino's old fashioned soda and candy shop. Celebration Belle Riverboat and Channel Cat Taxi is nearby so you can explore the mighty Mississippi River. The downtown area also includes gift shops, antique stores, restaurants and hotels!
The Original Huckleberry's Great Pizza and Calzones
A fun, casual Italian restaurant featuring good pizza, pasta and calzones in the heart of the District.
CITY:Rock Island
Whitey's Ice Cream Stores - Quad Cities
Created in the Quad Cities, outstanding flavors of ice cream, malts, shakes of every kind, banana splits, sundaes. Squeeky clean Ice Cream Shops all done up in White and Red and the ice cream servers are dressed white uniforms with red and white caps.
Le Mekong
Featuring Vietnamese Gourmet food during lunch and dinner hours. Set in a more formal dining atmosphere but casual dress is allowed. Full and delicious menu of wonderful appetizers, soups and entrees. Family owned for over 20 years. Restaurant also features a very nice selection of teas and a full bar selection.
Bishop Hill Bakery & Eatery
This is a family owned and operated business. Step up to the counter and watch fresh bread and cookies being baked right before your eyes. Be tempted with many baked goods or stay for lunch with homemade soup, casseroles, or a sandwich from the daily lunch menu. The bakery is located across from the Colony Store and Steeple building.
CITY:Bishop Hill
Ming Wah
Family-owned restaurant featuring homemade Chinese cuisine with lots of fresh vegetables. Delicious lunch and dinners! Great soups, appetizers and entrees. A local favorite!
Maid Rite
Old time diner featuring breakfast, lunch and dinner. Well-know for their famous loose meet sandwiches (Maid Rites). A Quad Cities original. Enjoy malts, fries and so much more at this 50's-style diner. A variety of locations throughout the Quad Cities.
Exotic Thai Restaurant
Featuring fine dining and fine Thai cuisine in a contemporary atmosphere. Restaurant include a delicious array of dished and a full bar and specialty drinks. Open Monday through Sunday for lunch and dinner. The food is a marriage of centuries old eastern and western influences that are harmoniously combined into something uniquely Thai.
Colony Inn
Friendly tavern serving food made on site. Decorated with historic sports memorabilia from local Bishop Hill teams.
CITY:Bishop Hill
Arthur's Garden Deli
Fresh deli sandwiches, soups, salads, salad bar, ice cream, yogurt desserts and more in a contemporary and friendly setting. Just walk up to the long counter, grab your tray and start ordering from a variety of menu items prepared right in front of you. Fresh, delicious and healthy choices!
CITY:Rock Island
Osaka Japanese Restaurant
Dependable and delicious Japanese cuisine. Sushi and bar area. Located right across from shopping at SouthPark Mall - serving lunch and dinner Monday through Sunday.
Good's Furniture Showplace
Start your exploration with a visit to Good's Furniture. America's Furniture Showplace is one of the oldest and largest family-owned furniture stores in the Midwest and is the centerpiece of Kewanee's downtown. The 250,000 square-foot showroom spans two city blocks and encompasses twelve restored buildings that feature over fifty furniture brands. It's a complete shopping experience: visit Good's Market Square Gift Emporium with unique gifts including upscale clothing and accessories, fine luggage, gourmet food and wine, and much more! Grab a bite to eat at the Wine Cellar Restaurant on Good's lower level. For an afternoon pick-me-up, stop by the Coffee & Wine Bar. A skywalk, glass elevators, and a Koi Pond add to the ambience. Visit for the day and pamper yourself with an overnight stay at the in-store European Bed & Breakfast.
El Mariachi Restaurante
Great home-cooked Mexican Cuisine and family-owned. Open for lunch, dinner and breakfast on Saturdays and Sundays. The restaurant is closed on Mondays.
Frank's Pizzeria
People line up for these delicious pizzas. Bring the whole family and have a seat. Choose from a variety of toppings on delicious handmade pizzas. Open since 1955.
Harris Pizza
A Quad Cities tradition for the finest pizza around. Voted a Quad Cities favorite, this restaurant has been around for over 30 years.
CITY:Rock Island
Red Earth Cafe
Serving breakfast, lunch and dinner while overlooking the 56-acre lake. Featuring buffalo burgers, vegetarian choices, homemade pie and daily features. Breakfast and lunch served Tuesday through Sunday 8 am to 2 pm. Dinner served Thursday through Saturday, 5 pm to 8 pm.
Fun food, sports, spirits in a casual dining atmosphere. Large beer select, great burgers, sandwiches and appetizers.
CITY:East Moline
PL Damron's Catering Cafe & Banquets
Follow the lunch crowd and dine in a beautifully preserved historic building where everything is homemade from the soups to the entrees. PL Damron's Café is known for its fresh baked breads, bakery treats (try the cinnamon and caramel rolls!), and pies. PL Damron's Barbecue is a house specialty with pulled pork, pulled rib, beef, and chicken served in a special barbecue sauce. PL Damron's Café also offers catering and banquet services. Hours:Tuesday to Thursday 7 a.m. to 8 p.m., Friday and Saturday, 7 a.m. to 9 p.m. Sunday, "The Scoop" open 4 p.m. to 8 p.m.
O'Melia's Supper Club
Enjoy dining in an old-style Supper Club setting with delicious steaks, seafood, and traditional American cuisine. Family-owned for over 30 years.
CITY:Rock Island
Station House Restaurant
Right on track to be our favorite destination! Located next to the downtown Amtrak Passenger Station. Indoor and outdoor dining available. Serving breakfast, lunch and dinner.
Chestnut Street Inn
Award winning bed & breakfast and restaurant featuring Mediterranean cuisine, using locally available ingredients. Conveniently located off I-80. Four uniquely appointed guest suites, including private bathrooms.
Pasteur Restaurant
Fine dining featuring gourmet French Vietnamese cuisine. Family-owned and operated.
Cerno's Bar and Grill
Gather your friends for fabulous food in a warm atmosphere featuring a spectacular 19th century historical bar. The menu selection offers great sandwiches, fantastic pizza, and dinner entrees. Enjoy over twenty different beers on tap at the mahogany back bar imported from Belgium by the Pabst Blue Ribbon Brewing Company.
Main Street Eatery
Try the top-secret honey-poppy seed dressing on top of the apple, celery, and chicken salad, it is a local favorite. Sandwiches, Panini's are just a few of the delectable offerings. Breakfast is available.
Jim's Rib Haven
Family-owned restaurant for over 30 years featuring the best ribs in the Quad Cities. Definitely a favorite among the locals. You can bring your own beer with you to drink at the restaurant. Also features great sides to go with your ribs.
CITY:Rock Island
Mary's Restaurant
Mary's Family Dining offers affordable home-cooked meals served on white table cloths. Lunch specials and a salad bar are offered daily. Enjoy the friendly lounge area while you wait for your seat.
Kewanee Dunes
After 85 years, the golf course is still going strong. This 18-hole championship course features beautiful mature trees, fast greens and great fairways. Enjoy a delicious meal in the clubhouse, Greenside Grill or Roy's Place. 18 holes with a cart: Weekday $32 Weekends $37
State Street Café
Homemade soups, daily specials, and freshly baked goods are just a few of the reasons to give this locally-owned stop a try.
La Rancherita
Family-owned Mexican restaurant featuring a fantastic array of homemade recipes.
CITY:Rock Island
Chestnut Street Inn
Award winning bed and breakfast and restaurant featuring Mediterranean Cuisine using locally available ingredients. If you are a foodie, you will love the Chestnut Street Inn. Chef Monika prepares Mediterranean inspired menus featuring locally sourced foods. Her passion for all things food related shines through in her creativity in the kitchen. You can enjoy an overnight and breakfast, a special prix-fixe dinner or even a cooking class. From free snacks and beverages available in the Butler's pantry to chocolates in the room to an expansive beer and wine list for purchase, anything your palate could desire is available here. Conveniently located off I-80. Four uniquely appointed guest suites, including private bathrooms.
Dr. Gyros
Typcial Gyro dishes piled high with all the fixin's. Get a basket order or just order a Gyro.
CITY:Rock Island
Sherry's Cafe
Sherry's is known for a few things: good food, great prices, and all the friendly service you can expect in Henry County. Located in an old quaint church, Sherry offers daily specials including fish, barbeque ribs, chicken, and more.
Country Morning Coffee
No chain store coffee here! Country Morning Coffee is the only artisan coffee roaster in Henry County, offering 30 different premium coffees plus organic coffees from around the globe. Every coffee batch is roasted daily and packaged by hand including personal handwriting on each coffee label. Pick from an assortment of coffee drinks, tea, hot chocolate, and iced drinks. Morning offerings include fresh home-baked pastries, and for lunch there's homemade breads and soups or Panini's and wraps. Fill your travel mug and grab some freshly blended bags of coffee to take home with you!
Purple Onion
When you're in the market for comfort foods in Annawan, the Purple Onion is your spot. The homemade pies are a must-order item.
The Dutch Diner Family Restaurant
Casual family dining specializing in home-made pies. Excellent hot meals with large portions.
Lisa's Place
Down home service features home baked bread and rolls, home cooked soups and entrees. Specials are served daily. "The Nest" is a specialty; ask about it! Breakfast served all day on Saturday.
Creekside Vineyards Winery & Tasting Room
Welcome to the realm of wine, weekend wanderlust, midweek getaways, and what we like to call Wine-derful! Just south of the Quad Cities, wine enthusiasts can discover their own "hidden gem" of a vintage at Creekside Vineyards Winery & Tasting Room. This circa 1938 building, once a family diner & service station, now offers travelers a stopover of good conversation & fantastic artisan wines.
JP's Landing Bar & Grill
We're located right along Rt 84 on the Great River Road and also have outside seating with a great view of the Mississippi River. We cater to boaters, bikers and everyone in between. so visit by car, bike or boat!
Boetje's Mustard
Boetje's Mustard is a national-favorite. Beginning in 1889, Fred Boetje began making stoneground Dutch mustard in his garage in Rock Island, Illinois. Using the same recipe today of water, mustard seed, sugar, salt and distilled vinegar, Boetje's tops all mustard sales in the local retail market.
CITY:Rock Island
Geneseo Brewing Company
Est. Sep 2014. Offering continually new & unique quality craft beer ~ in a comfortable environment. There's sure to be something for everyone to enjoy!
Lionstone Brewing Company
We are a family owned brewery operating in our hometown of Geneseo, IL. Our brewery is in full operation and our taproom and gastropub is a great place to enjoy unique food and beer combinations.
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Jimmie N. Wombwell, 79, Tonganoxie, KS, died Wednesday November 21, 2012 at the Tonganoxie Nursing Center.
Funeral service will be 10 am Monday November 26, 2012 at the Quisenberry Funeral Home, Tonganoxie. The family will receive friends from 2-4pm Sunday November 25, 2012 at the funeral home. Private burial will be held in Leavenworth National Cemetery, Leavenworth, KS.
Location, ST | website.com


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I hate the automatic saving and versioning in Mac OS X Lion.
Is there a way to completely turn it off?
(This has been asked before here, but the answer and the linked article are completely wrong, so I thought I'd try again.)
I intentionally was searcing for hidden defaults1 and fortuitously stumbled across a
If you have a tolerance for potentially breaking things (joke), try the following Terminal command (for Preview in this example):
Alternatively, you can configure this globally with this command (but beware that this causes slow logins, so not recommended):
I can confirm that this works for TextEdit, Preview, Automator and Safari (for disabling Resume), but it should also work for other Apple applications like iWork, Xcode, iPhoto etc. It also works for some, but not all, third party applications. My machine hasn't gone up in flames (joking again) but as long as you have a good backup system, these settings seem stable to change and test.
For TextEdit, you must additionally run the following command, in order to avoid sandbox errors:
[This effectively disables the old-style, pre-Lion autosaving completely, so the sandbox won't complain anymore about TextEdit trying to automatically save stuff without your "consent".]
Another option, is a TextEdit fork called "TextEdit+", that thankfully isn't sandboxed (surprisingly, TextEdit is actually open source). It can be downloaded here.
To restore normal behaviour, run:
1 Thanks to Lri for his excellent one-liner for finding hidden
I agree, too many assumptions on Apple's side what users need and especially what can be controlled by the user → hint: new full-screen apps on dual-/multi-monitor setups (fail)
For Versions it's quite similar, no control for the user :(
The only thing I found so far is checking the size of the Versions folder
Note: This is a very bad idea ! It will delete all your previous versions of doucuments/files
You could then prevent the re-creation of that directory by
But that creates a big mess, leaving you unable to re-save documents in Apps featuring "Versions & Autosave"
Not a satisfying solution. I really hope someone finds a way to turn it off or that one of the next OS X updates gives the user more control.
Hackinations: 5 really good Lion tweaks mentions that the switch
And it seems the deamon
Anyone with better ideas ?
I found a way to disable Versions (not Autosave) in a (hopefully) non-destructive reversible way: (re)move the SQLite database that Versions uses
Careful, this comes with absolutely no warranty and may break your system!
If it worked you'll be notified e.g. in Textedit when you close a document:
That (probably) means that your document will still be automatically saved in certain intervals, but once you close it (or the program) you can only retrieve the latest version (and Time Machine backups, if available).
The changes can be undone with
Edit 2012-04-04:
Versions (especially of Autosave) may still end up in
There is a much much simpler way to do it that was only introduced in OS X 10.8 Mountain Lion.
According to this post, you just have to enable System Preferences > General > Ask to keep changes when closing documents.


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New inFamous: Second Son screens and concept art releasedWritten by: / / 4 Comments
Despite inFamous: Second Son being only two months away it's fair to say that we've only seen a small fraction of what this visually impressive PS4 title has to offer. Last week we were treated to ten minutes of off-screen demo footage from CES 2014 and over the past few days the official Twitter account of developer Sucker Punch Productions has been teasing us further with three new screens and a piece of concept art for the game.
One of the things developers seem excited for as they get more familiar with new-gen hardware is the ability to create more believable worlds thanks to graphical elements such as dynamic puddles and real-time reflections on wet surfaces. The first new inFamous: Second Son screenshot is a great example of these reasonably recent technical advances, while the second image shows some complex particle systems at work. Take a look below:
inFamous: Second Son is due out on March 21st worldwide. Head over here for El33tonline's previous coverage of this spectacular open-world action title, which includes Oliver's preview from E3 2013 and my preview from gamescom 2013.
Tags: conceptart, infamoussecondson, sony, suckerpunchproductions


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"Wild things that I wouldn't do if I wasn't drunk."
This young woman, who wishes to remain anonymous, says when she was under the influence of alcohol it made her act differently and got rid of her inhibitions.
"I'd go driving around with friends while we were drinking. Just doing stupid stuff. Just, I don't know, kissing guys I didn't even like or hanging all over guys I didn't know or like. Just a lot of things."
The age teenagers try their first drink of alcohol is younger than you may think. This young woman had her first drink when she was 13.
"With my friends. Just going to parties with my friends. Basically just social drinking."
She says it's not hard for teenagers to get alcohol either.
"Older people we know. Out of high school or whatever. We just went and asked them to go buy us beer. We'd just stop at the liquor store and ask somebody to go buy some beer for us."
Drinking alcohol can affect judgment and be a coping mechanism for other problems.
"It's just a mood-altering substance. It's just like any other thing. It made you feel more outgoing. Like you didn't have to be yourself. You can just be wild and outgoing and then the next morning you don't have to remember anything you did."
Wanting to cover the pain of problems she had with her family, she began to look for other ways to forget things.
"Well, it kind of escalated into more serious drugs."
She says she tried marijuana a couple of times, but her friends urged her to try cocaine and meth to get high instead.
"I started doing those things and once I got on the meth I liked the speed and stuff. I liked the way it made me feel and so I kept on doing that. Until one day it just got out of control. I couldn't handle how much I did. But I wanted it all the time."
The effect of alcohol and drugs took a toll on her grades and performance at school as well.
"My grades started to fail because I wouldn't go to school. I didn't want to go to school. I even thought about dropping out. Because I was so into drugs I didn't want to go to school anymore. But I was a really good student before I started doing them."
The alcohol and drug addiction drove a deeper wedge into her already-troubled family life.
"My family, me and my family we didn't talk anymore. I didn't go to see them. I didn't care about them. All I cared about were my friends. Just wanted to get high."
After being high on meth for several days she became so emotionally upset she tried to commit suicide.
"I was so depressed. And I didn't have anybody. I didn't have my family left. So I was just like, I don't want to live anymore."
She was sent to a crisis center after her suicide attempt and from there she went into rehab.
"After I got out of rehab and I went back to school, it's been great. I've met new people, made new friends. I've started to hang out with people who didn't do drugs. And I found as long as I hang out with positive people, I'll be more positive myself."
She now has a strong will to stay sober.
"I say no. I try to avoid those places now that I've been through it. I don't want to go back. I try to avoid everybody who does it and going to those places. I just hang out and do what regular people do instead of put myself in that position."
wbko.com Extended Web Coverage
Teen Alcohol Abuse
Source: National Council on Alcoholism contributed to this report


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I came up with an idea similar to this one (us20070091093) around the same time and I've read this patent pretty thoroughly. They cover a large part of what my idea is, but I have differences in execution and the fact that it is not directly clicking on the video that they have stated. If it is close enough that my idea would fall under this patent how do I go about opening dialogue for using parts of the patent in collaboration with my device. Also, I believe my idea may be different enough, but I am not sure who I would need to ask to evaluate this claim. Any advice or assistance that you can offer would be most helpful. Thank you for your time and consideration.
To briefly answer some of your more general questions before diving into the weeds:
You'd want to contact the assignee and express interest in taking a license. In this case, that would be Microsoft. You could start here: http://www.microsoft.com/about/legal/en/us/intellectualproperty/iplicensing/
BUT you should really consult with a lawyer before doing so, in order to make sure you don't wind up getting in over your head (by, say, accidentally providing them with an admission your product would infringe their patent that could later be used against you).
A registered patent attorney or agent is really the only person who can give you a competent opinion on this, but even then there's a certain amount of crystal ball gazing involved. Be suspicious of anyone who gives you black and white/yes and no answers.
As to the specific patent you're concerned about:
The link you provided is to a published patent application. The claims of applications are frequently quite broader than the claims in any patent that ultimately issues, as the applicant generally tries to initially claim a fairly broad scope which is then reduced during the application's prosecution as the examiner finds prior art that reads on the broader claims. In this case, the application issued as a patent, which you can tell by looking here:
If you look at the claims of the patent that actually issued, they're quite a bit narrower.
Claim 1 of the application you're looking at defines:
While claim 1 of the actual patent defines:
However, you also have to keep in mind that the reason the scope of the application's claims were narrowed is almost certainly because there are other patents that cover that subject matter. If you want to see if any of those patents cover your idea, you'll have to look up this patent's prosecution history, download the rejections the examiner issued during prosecution, and look at the references he cited against the claims.
You can look up the public documents associated with a patent or published application on the Patent Application Information Retrieval (PAIR) website:
Once you fill out the CAPTCHA, look up the patent and click on the Image File Wrapper Tab. That will give you a list of all the documents you can look at with respect to this particular patent:
Hope that was enough information to get you started. Good luck.


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Monday, August 07, 2006
The Best Psychological Test of All
But how can we know if we're truly operating in our ideal niches, whether in trading, romance, or careers? It turns out that there is a very simple psychological test that can provide this information.
Keep a journal of your emotional experience: how you are feeling at the end of your mornings, afternoons, and evenings. Make particular note of the number of occasions in which you were totally absorbed in what you were doing--so much so that you lost your sense of time passing and lost your awareness of yourself. Also make note of occasions in which you felt frustrated for any reason.
The result of your psychological test is simply the ratio of occasions in which you are absorbed to occasions in which you are frustrated. It turns out that highly creative, productive, and successful individuals have an unusually high ratio.
The reason for this is that these successful people are operating at that nexus of interests, talents, and skills. Because they're doing what they love and have the resources to do it well, they become wholly absorbed in their experience. This is the "flow" state described by Mihalyi Csikszentmihalyi: a pleasurable, altered state of consciousness, in which we feel at one with our situation.
During frustration, on the other hand, we are either doing something that doesn't interest us or something for which our skills and talents are poorly matched for the demands of the task. If task demands are too easy, we become frustrated with boredom. If task demands are excessive, we become frustrated by our inadequacies. Frustration divides subject and object; in flow, those are joined. It's the difference between a highly satisfying sexual experience and a highly unsatisfying one.
If you're operating in your proper niche, you will be experiencing a state of flow on a regular basis. You will be doing what you do well, and you will love and value what you're doing. That is true for the job you're in, the marriage you're in, and the trades you're in. That psychological test applies to most of life's arenas.
Too often, we justify frustration today by the vague hope of fulfillment tomorrow. In my book, I mentioned the Kansas bar near my home where a neon sign promised "Free Beer Tomorrow". Of course, naive patrons who returned the next day were always told that the free beer was, indeed, tomorrow.
In the end, life is a succession of situations: careers you're in, people you know, relationships you enter, markets you trade. You are your situation: you always experience the fit--or lack of fit--between who you are and what you're doing. Successful people find good fits in life: their situations bring flow. Taking your emotional temperature at the end of trading days--assessing your periods of flow and frustration--will tell you a great deal as to whether or not you're in the right markets, with the right methods, in the right timeframes, with the right skills.
Don't settle.
4 comments:
- Calex said...
This is brilliant! I've thought along these lines most of my life and have often made changes that seemed rash or impulsive from the outside but made perfect sense to me on the inside. I have a good friend who is struggling to find these characteristics in her professional life and last night I quoted your blog to her in an email. Then I looked today and your blog follows through. You really laid it out in a simple and elegant manner and I am looking forward to getting my friend to try the test. She is a very talented woman and is too often frustrated. Thank you for your wisdom!
- Brett Steenbarger, Ph.D. said...
Thank you for the kind words, Calex, and best of luck with your friend. Sometimes we don't trust our inner inclinations, but many times they're taking us where we need to go.
- yinTrader said...
Hi Brett
Discipline is the hardest part to overcome when learning to trade successfully, speaking from experience.
Having gone through the mill the last few months has finally convinced me to try harder and change to stick to discipline ie a Mechanicl System as a novice.
Going back to school
- Brett Steenbarger, Ph.D. said...
Although I do not trade mechanically, I do find it helpful to have hard and fast trading rules to guide my decisions. My experience, FWIW, is that these rules limit the number of trades that I take, but increase the % winners. One rule, for example, is to stop trading when the average 5 min ES volume falls below a threshold level, as this suggests that there will not be sufficient volatility to create a good risk/reward balance.


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Three top Democrats in the House endorsed their former colleague Sen. Barry Finegold for state treasurer on Tuesday, siding with the Andover Democrat in his primary race over current House member Rep. Thomas Conroy of Wayland and former Brookline Selectman Deb Goldberg.
The Finegold campaign announced that it had picked up endorsements from Majority Leader Ronald Mariano of Quincy, Ways and Means Chairman Brian Dempsey of Haverhill, and Speaker Pro Tempore Patricia Haddad of Somerset.
Finegold served in the House from 1997 until 2011.
Location, ST | website.com


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Hi Friends How to create explorer like menu in Html or java script? eg + Game(inside this Cricket and Football) when click on + sign it become like-- - Game -Cricket -Football Can anybody suggest me, by which command I can do it? pls reply
Related to Html and Java Script?
thnks my for reply for me


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I've encountered some strangeness while using RSyntaxTextArea. The document I'm editing sometimes contains hidden newlines. Hidden as in that they do not affect how the document is displayed (a line does not continue in a newline) but are there anyways.
Sometimes when I delete newlines while editing (Backspace), these hidden newlines remain. If I save such a document to a file on the filesystem and reopen it, the document is formatted the same way as before the change...as if nothing had happened.
I know that these hidden characters are there, since I can navigate them using keyboard arrow keys after deleting a newline. There's a "blank" hit, when I move the caret using the aforementioned keys (at some point I have to use left or right arrow twice to move the caret one unit to left or right respectively). If actions behind these keys don't ignore these hidden newlines, why does the action that handles deletion? Note that these actions come bundled with RSTA and were left untouched.
Both the RSTA XML Tokenizer and the third party parser I'm using also see these newlines. When I copy pasted some XML from an email that had been mangled by the email client (some tag names and text values were split in twine with additional newlines) and attempted to edit it manually to remove them newlines, I actually ended up with a tag that looked like a proper XML tag, let's say <diskUsageApp>, but was colored as if the "App" part were an XMLAttribute token! And the parser of course complained of an improper syntax of the "App" attribute...
I suspect it has something to do with those evil null tokens at the end of the lines. Any idea as to what might be causing this?
I get this using 2.0.3, 2.0.2 or 2.0.1 (unsure).
It is actually deleting with Delete key, that seems inconsistent (not Backspace). I cannot delete the invisible newline with Delete, but I can with Backspace (it is aware of them like the arrow keys). The thing is...I shouldn't have to bother with deleting something that cannot be seen.


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I recently attended a talk by Dr. Ravi Gomatam on 'quantum reality', where the speaker suggested, that conservation of energy is not a fundamental law, and is conditional, but the conservation of information is fundamental. What exactly is the meaning of information? Can it be quantified? How is it related to energy?
If one measures lack of information by the entropy (as usual in information theory), and equates it with the entropy in thermodynamics then the laws of thermodynamics say just the opposite: In an isolated system, energy is conserved wheras entropy can be created, i.e., information can get lost.
The main stream view in physics (aside from speculations about future physics not yet checkable by experiment) is that on the most fundamental level energy is conserved (being a consequence of the translation symmetry of the universe), while entropy is a concept of statistical mechnaics that is applicable only to macroscopic bodies and constitutes an approximation, though at the huma scale a very good one.
In contrast to @ArnoldNeumaier, I'd argue that the information content of the World could be constant: it almost certainly can't get smaller and how it and if it gets bigger depends on the resolution of questions about the correct interpretation of what exactly happens when one makes a quantum measurement. I'll leave the latter (resolution of quantum interpretation) aside, and instead discuss situations wherein information is indeed constant. See here for definition of "information": the information in a thing is essentially the size in bits of the smallest document one can write and still uniquely define that thing. For the special case of a statistically independent string of symbols, the Shannon information is the mean of the negative logarithms of their probabilities $p_j$ of appearance in an infinite string:
$H=-\sum_j p_j \log p_j$
If the base of the logarithm is 2, H is in bits. How this relates to the smallest defining document for the string is defined in Shannon's noiseless coding theorem.
In the MaxEnt interpretation of the second law of thermodynamics, pioneered by E. T. Jaynes (also of the Jaynes-Cumming model for two level atom with one electromagnetic field mode interaction fame), the wonted "observable" or "experimental" entropy $S_{exp}$ (this is what the Boltzmann H formula yields) of a system comprises what I would call the true Shannon information, or Kolmogorov complexity, $S_{Sha}$, plus the mutual information $M$ between the unknown states of distinguishable subsystems. In a gas, $M$ measures the predictability of states of particles conditioned on knowledge about the states of other particles, i.e. is is a logarithmic measure of statistical correlation between particles:
$S_{Exp} = S_{Sha} + M$ (see this reference, as well as many other works by E. T. Jaynes on this subject)
$S_{Sha}$ is the minimum information in bits needed to describe a system, and is constant because the basic laws of physics are reversible: the World, therefore, has to "remember" how to undo any evolution of its state. $S_{Sha}$ cannot in general be measured and indeed, even given a full description of a system state, $S_{Sha}$ is not computable (i.e. one cannot compute the maximum reversible compression of that description). The Gibbs entropy formula calculates $S_{Sha}$ where the joint probability density function for the system state is known.
The experimental (Boltzmann) entropy stays constant in a reversible process, and rises in a non-reversible one. Jaynes's "proof" of the second law assumes that a system begins with all its subsystems uncorrelated, and therefore $S_{Sha} = S_{exp}$. In this assumed state, the subsystems are all perfectly statistically independent. After an irreversible change (e.g. a gas is allowed to expand into a bigger container by opening a tap, the particles are now subtly correlated, so that their mutual information $M > 0$. Therefore one can see that the observable entropy $S_{exp}$ must rise. This ends Jaynes's proof.
See also this answer, for an excellent description of entropy changes an irreversible change. The question is also relevant to you.
Energy is almost unrelated to information, however, there is a lower limit on the work must do to "forget" information in a non reversible algorithm: this is the Landauer limit and arises to uphold the second law of thermodynamics simply because the any information must be encoded in a physical system's state: there is no other "ink" to write in in the material world. Therefore, if we swipe computer memory, the Kolmogorov complexity of the former memory state must get pushed into the state of the surrounding World.
Afterword: I should declare bias by saying I subscribe to many of the ideas of the MaxEnt interpretation, but disagree with Jaynes's "proof" of the second law. There is no problem with Jayne's logic but (Author's i.e. My Opinion): after an irreversible change, the system's substates are correlated and one has to describe how they become uncorrelated again before one can apply Jaynes's argument again. So, sadly, I don't think we have a proof of the second law here.


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As HSF's Chief Digital Officer, Ms.Bailey is responsible for developing and executing the organization's technology, data, and digital strategy. More specifically, her charter is to lead her team in building and maintaining the technology that enables HSF to execute its mission through its many programs and services, as well as its administrative functions. Under her leadership, HSF's technology drives the broad-based acquisition of individual donors; engages stakeholders via relevant media channels and two-way marketing; employs analytics that support current scholars, prospective applicants, alumni and parents; and provides value for HSF's corporate and foundation partners.
Prior to joining HSF, Ms. Bailey was Vice President and Divisional CIO for Sony Pictures Home Entertainment (SPHE), a multi-billion-dollar division of Sony Pictures Entertainment. In that role, she oversaw the Global Information Technology strategy and direction to support and enable Home Entertainment's business operations, including sales, marketing, manufacturing, distribution, business intelligence, finance, and digital functions.
Ms. Bailey has more than 20 years of experience in the entertainment industry, having held various management and leadership roles in accounting, customer service, sales, operations, and IT. Her experience in tactical execution, management processes, and strategic planning has allowed her to helm many strategic initiatives, company projects, startups, and departments. Her merging of strategic vision, aligning business and IT, and integrating business processes with technology, which were pivotal in her role at Sony, are now the crux of her technology strategy at HSF.
Her vision is to evolve an integrated and collaborative Technology and Data Team to provide innovative methods of adopting and adapting technology to achieve HSF's strategic goals. Building on her experience at SONY, she also aims to institutionalize continuous improvement and use of "best of the best" practices at HSF.
In her spare time, Ms. Bailey serves on the all-volunteer board of the non-profit California Hispanic Corporate Council (CHCCLI) to promote Latino leadership development and advancement in the corporate, government, and nonprofit sectors. She is the Corporate Council Chair for Los Angeles Unified Preschool (LAUP), a non-profit organization that helps provide access to early childhood education programs for families that could not otherwise afford them.
She has also been a board member of the LMU Latino Alumni Association since 2010 and serves on LMU's Corporate Advisory Council. And she is a proud NHLI Executive Leadership Program Fellow alum from 2010. She was also very active in Sony's corporate diversity and inclusion program, SPECTRUM, and served on the Advisory Board and as the Executive Sponsor of the Latinos Unidos Employee Business Resource Group (EBRG).
Ms. Bailey holds a Bachelor's degree in Business Administration with an emphasis in International Business from Loyola Marymount University, and a Master's degree in Business Administration in Information Systems and Operations Management from the University of Southern California.
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Describe your experiences with the Moore method. What are its advantages and disadvantages?
One thing that should be mentioned is that the "Moore Method" is not precisely defined. There are many variations and many selections of students and professors.
Along these lines, I've taught a "self-paced" calculus I course twice. The students were given a massive load of homework problems, and each student had their own homework (everyone had "differentiate these polynomials", but each student had their own polynomials). I encouraged working together, and we spent most of the lecture time working homework in small groups. The exams were generated automatically, and the students had access to many "sample exams". Each student took the exams during office hours, at a time of their own scheduling (with a deadline). The homework was graded through Webwork, so that students could easily email me questions about particular problems. I received about 1200 emails the first semester, and around 800 the second.
The student evaluations for those two sections are the worst student evaluations I've ever received. In part, the stock questions are more geared to evaluating a traditional section, but mostly I think this was because the course was a lot of work for them. Both semesters, about half the class used all that extra rope to hang themselves (metaphorically). One semester, there was a group of 4 students who became competitive, in a friendly way, and became 4 of the best students I've seen at my current institution.
But perhaps the most telling factoid is this. In five years at this school (teaching perhaps 20 courses), I've had three students go out of their way to find me later and say that my course was the best course they've had, the one they learned the most in, the one that set the tempo for the rest of their studies. Not asking for a letter, mind, just wanting to say "thank you". Only one of the three was a math major. Two of the three students were from the first time I taught that way, and the third was from the second time.
I took a class using the Moore method during my freshman year as an undergraduate (back in 1998). I really enjoyed it, but now that I've acquired a bit more teaching experience I think the following points should be made. I should remark that I've never tried teaching a course using this method myself.
1) Like Felipe said, it is not good for conveying a lot of information. It is more of an ``experience''. It is thus best for classes like baby-Rudin style analysis classes in which there are few hard theorems and not too much that HAS to be covered.
2) It is important that the class is small and that the experience/talent levels of the students are relatively equal.
3) I think that such classes can be valuable to a certain kind of student (one who is relatively strong already and who enjoys competition), but I don't think it should be mandatory. Maybe one section out of a multi-section class.
I want to elaborate a bit on the third point. I think the stereotype of mathematicians as aggressive and hyper-competitive is a dangerous one, and has the effect of discouraging students who do not fit that stereotype. It is important that when a course like this is offered, an effort is made to clarify that not all students need to take it. I could envision a culture developing where the Moore method section has a reputation as being the "real section" for the "best students". The faculty need to make a serious effort to prevent this from happening.
I taught a course on Galois theory at Canada/USA Mathcamp. The context was certainly different from a regular university or college: there were no exams or evaluations of any kind, and students choose their own courses and drop casually out of them if they wanted. I started with 28 students (many of whom did not belong there), and ended with only 14. I think that 10 out of those 14 had learned a significant amount of material rather than being over their heads, and 4 out of those 10 understood everything we had done perfectly. When you compare this with the outcome of teaching a course on Galois theory with traditional method, it is not bad at all.
It is true that the material is covered slower than we traditional lecture, but I believe that students learn more. The students who finished the course were certainly enthusiastic and I had the same experience that Kevin tells in his last paragraph.
Finally, I will add that a competitive atmosphere is not necessary for the Moore method to work. (Yes, Moore's original course required aggressive and competitive students, but there are many things we call Moore method now.) In my case, it was more of a community working together. I recall how, after proving the fundamental theorem of Galois theory, a student was attempting to compute $\cos \frac{2\pi}{17}$ explicitly (in an afternoon, preparing for the class for the next day), and he was surrounded by a group of other students, eager following the process and cheering him on.
In short, after my limited experience, I am a big supported of the Moore Method and other variations. Particularly for students who want to go on to become mathematicians, it gives them a more realistic taste of what math is than a traditional course.
I think the Moore method is a very inefficient way of imparting information. On the other hand, students profit by having a class taught by the Moore method, since it forces them to think in a different way. My view would be that Math majors should take one (but no more than one) class taught by the Moore method.
The Moore Method has other variants grouped together under the "IBL" (Inquiry Based Learning) umbrella. I just finished teaching an intro (undergrad) real analysis course using an IBL script instead of a textbook and am amazed at how much more solidly all of my students absorbed the information in the course.
Certainly, this method doesn't move as quickly as traditional methods, but students assimilate the information so much more fully this really doesn't matter.
BTW: If you are interested in resources for running such a course, there are refereed IBL scripts in the journal of inquiry based learning in mathematics.
I am a very latecomer to the question. Thus, I doubt my contribution will do any good. I try. The Moore Method is one of my favorite "teaching" methods. I have used a variant of it several times and in particular in two courses: Multivariable Calculus and Number Theory. For the former, I designed the course myself (for details see my paper "Moore and Less" : http://www.tandfonline.com/eprint/jGE3QNxcuGzUGj273smp/full), For the latter, I used "Number Theory Through Inquiry" (http://www.maa.org/ebooks/textbooks/NTI.html). Generally speaking, the advantages have been mentioned more or less in the previous answers/comments. Thus, I focus on potential disadvantages.
Playfulness: The Moore Method strictly used is not that much playful. The point is you have a setting in which the materials have been prearranged. This forces you and your students to stay on a predesigned track, and as a result, hinders useful and playful jumps. Let me give an example. Suppose you start with some examples of primitive Pythagorean triples. The most famous ones are (3, 4, 5) and (5, 12, 13). Observation: the difference between two of the numbers is one. Having characterized Pythagorean triples, it would be natural to move to Pell equation. However, since the materials have been prearranged, you should continue with Lemmas ., Theorems . , all directly related to Pythagorean triples.
Naturalness: Again, this is somehow related to the prearrangement. As a designer, you feel that you should provide some backgrounds to help students to prove a certain theorem. What you provide is natural for you since you already know the proof of the theorem. However, it is not so natural for most of the learners. Let me go with the previous example. Moving towards the theorem characterizing Pythagorean triples you write (your students read): "It turns out that there is a method for generating infinitely many Pythagorean triples in an easy way. It comes from looking at some simple algebra from high school. Remember that … ". It gives me a very bad feeling to behave with my students in this way, to say the least. The problem arises even for the lecturer when others have designed the course. An arrangement that is natural for somebody else is not necessarily natural for you.
Forcefulness: Your students are forced into forward thinking. There is a theorem (again take the previous one as an example). You are somehow sure that your students need some help to prove it. Where do you provide that help? As a Lemma before the theorem!
Connectedness: This one is very strange and paradoxical. While you are connected with individuals and/or small group of students working together, you lose your connection with the class as a whole.
There are some other points. I stop here since my answer is already too long. Moreover, I couldn't find suitable words ended with "ness" to describe the other points ☺


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$5 sale at brightbots.com.au
Started by ellebelle , Feb 19 2013 09:06 AM
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Posted 19 February 2013 - 09:06 AM
Bright Bots is clearing a whole lot of stock under the BB brand and also Max & Tilly and Olliboo for $5, three days only. www.brightbots.com.au Mostly for babies but some toddler stuff up to size 3. There's also some bigger sizes 2-7 but they are not $5, though still on sale.
Posted 20 February 2013 - 09:12 PM
Thanks Have told a friend who is in need.
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Jessica Gelber, Assistant Professor Philosophy at Syracuse University, will present "What is the Point of Teleological Explanation?" at 3pm Friday, December 9 in Welles 123.
Gelber received her PhD in Philosophy from the University of California at Berkeley. Her primary research interests are in Ancient Greek and Roman philosophy, with emphasis on ancient science and medicine. Her current projects focus on Aristotle's philosophy of biology, philosophy of science, and metaphysics.
This colloquium is presented by the Philosophy Department. For additional information, please contact David Levy or Steve Bein.


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NORD gratefully acknowledges Amy E. Roberts, MD, Assistant Professor of Medicine, Harvard Medical School and Cardiovascular Genetics, Division of Genetics and Department of Cardiology, Boston Children's Hospital and Judith Allanson, MD, Chief of Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa and Professor of Pediatrics, University of Ottawa, for assistance in the preparation of this report.
Noonan syndrome is a common genetic disorder that is typically evident at birth (congenital). The disorder is characterized by a wide spectrum of symptoms and physical features that vary greatly in range and severity. In many affected individuals, associated abnormalities include a distinctive facial appearance; a broad or webbed neck; a low posterior hairline; a typical chest deformity and short stature. Characteristic abnormalities of the head and facial (craniofacial) area may include widely set eyes (ocular hypertelorism); skin folds that may cover the eyes' inner corners (epicanthal folds); drooping of the upper eyelids (ptosis); a small jaw (micrognathia); a depressed nasal root; a short nose with broad base; and low-set, posteriorly rotated ears (pinnae). Distinctive skeletal malformations are also typically present, such as abnormalities of the breastbone (sternum), curvature of the spine (kyphosis and/or scoliosis), and outward deviation of the elbows (cubitus valgus). Many infants with Noonan syndrome also have heart (cardiac) defects, such as obstruction of proper blood flow from the lower right chamber of the heart to the lungs (pulmonary valvular stenosis) and hypertrophic cardiomyopathy. Additional abnormalities may include malformations of certain blood and lymph vessels, blood clotting and platelet deficiencies, learning difficulties or mild intellectual disability, failure of the testes to descend into the scrotum (cryptorchidism) by the first year of life in affected males, and/or other symptoms and findings.
Noonan syndrome is an autosomal dominant genetic disorder caused by abnormalities (mutations) in four main genes: PTPN11 (50%), SOS1 (13%), RAF1 (3-17%), KRAS (less than 5%), with a handful of individuals having a mutation in NRAS, BRAF or MEK2. Noonan-like disorders are found in association with mutations in SHOC2 and CBL.
In individuals with Noonan syndrome, associated symptoms and physical findings may vary greatly in range and severity from case to case. Some affected individuals have only minor facial abnormalities; others may have the majority of symptoms and findings associated with the disorder, such as distinctive malformations of the head and facial (craniofacial) area, a broad or webbed neck, short stature, skeletal malformations, congenital heart defects, malformations of certain blood and lymph vessels, blood clotting and platelet deficiencies, mild intellectual disability, and/or other abnormalities.
Most infants with Noonan syndrome have characteristic craniofacial malformations. In many cases, the head appears relatively large. Affected infants may have several abnormalities affecting the eyes including widely set eyes (ocular hypertelorism) that are unusually prominent; drooping of the upper eyelids (ptosis) and/or unusually thick, "hooded" eyelids; abnormal deviation of one eye in relation to the other (strabismus); downwardly slanting eyelids (palpebral fissures); skin folds (epicanthal folds) that may cover the eyes' inner corners; and/or strikingly blue or bluish green colored portions of the eyes (irides).
In many cases, infants with Noonan syndrome also have additional craniofacial features. These may include an unusually deep vertical groove in the middle of the upper lip (philtrum); and/or a small chin. Affected infants may also have a small jaw (micrognathia); crowding of the lower teeth, low-set, posteriorly rotated external ears (pinnae); and/or distinctive abnormalities of the nose including a depressed nasal root, a wide base, and a rounded (bulbous) tip. Affected infants also often have excessive skin in the neck area (nuchal skin) and a low hairline at the back of the neck (low posterior hairline).
In individuals with Noonan syndrome, facial features tend to change in a predictable manner with age. During later childhood, the face may appear relatively coarse and begin to appear more triangular in shape; in addition, the neck lengthens, causing the webbing of the neck (pterygium colli) to appear more pronounced and/or the large, triangular muscles of the upper back and shoulders (trapezius) to appear more prominent. During adolescence, the nasal bridge is thinner and higher, with a "pinched" root and wide base, and the eyes appear less prominent. During older adulthood, characteristic features may include an abnormally high hairline on the forehead; wrinkled, unusually transparent skin; and unusually prominent folds between the nose and the lips (nasolabial folds). In addition, individuals with Noonan syndrome may have wispy scalp hair during infancy that typically becomes more wooly or curly during later childhood or adolescence. Many affected individuals also have distinctive eyebrows that appear highly arched and/or "diamond shaped."
In many cases, newborns with Noonan syndrome attain normal birth weight. However, in some newborns, the birth weight may be increased due to abnormal accumulations of fluid between layers of tissue under the skin (subcutaneous edema). For example, swelling of the back of the hands and top of the feet (peripheral lymphedema) is common in newborns with Noonan syndrome; in such cases, edema affecting the fingers may result in an increased number of whorls on the fingertips (abnormal dermatoglyphics). Such edema may be due to improper or late development of certain lymph vessels (congenital lymphatic dysplasia).
Some infants with Noonan syndrome may experience feeding problems and fail to grow and gain weight at the expected rate (failure to thrive). In addition, children with the disorder tend to be short for their age, and approximately 20 percent experience delayed bone maturation. Most affected children have a relatively normal growth rate (velocity) before puberty; however, the growth spurt that is typically experienced during puberty may be reduced or absent in some adolescents. According to reports in the medical literature, average adult height is approximately five feet, four inches (162.5 cm) in males with Noonan syndrome and approximately five feet (152.7 cm) in females with the disorder. Individuals with the disorder typically reach their adult height by the end of the second decade of life. Growth patterns are influenced by the molecular genetic cause of NS. People with NS harboring mutations in RAF1 and SHOC2 are shorter than other genotypes, whereas those with SOS1 and BRAF mutations have more preserved growth.
Some males and females with Noonan syndrome may also experience abnormalities in the development of secondary sexual characteristics. In approximately 60 to 75 percent of males with Noonan syndrome, one or both testes fails to descend into the scrotum (unilateral or bilateral cryptorchidism) before birth or during the first year of life. If not corrected surgically, male reproductive cells (spermatozoa) may fail to develop properly within the testes (deficient spermatogenesis), and some affected males may experience infertility (sterility). Other males with Noonan syndrome may experience a delayed yet normal acquisition of secondary sexual characteristics (e.g., increased growth of the testes, scrotum, and penis; appearance of facial and pubic hair; etc.). According to the medical literature, puberty may be delayed an average of two years in such cases. Other males with Noonan syndrome may experience normal pubertal development. Even in the absence of a history of cryptorchidism, adult males appear to have decreased fertility. In females with the disorder, the acquisition of secondary sexual characteristics (e.g., the appearance of pubic hair, breast development, menstruation) may be mildly delayed but is more often normal. Most females with Noonan syndrome have normal fertility.
In many cases, individuals with Noonan syndrome also have skeletal abnormalities. Approximately 70 percent of affected children have a distinctive chest malformation characterized by abnormal protrusion of the upper (superior) portion of the breastbone (sternum) and/or abnormal depression of the lower (inferior) portion of the breastbone (pectus carinatum and/or pectus excavatum, respectively). In addition, the chest may be unusually broad, and the nipples may appear low set. In some cases, affected individuals may have additional skeletal malformations including rounded shoulders; outward deviation of the elbows (cubitus valgus); abnormally short fingers (brachydactyly) with blunt fingertips; and/or front-to-back and/or sideways curvature of the spine (kyphoscoliosis). Children with NS have a significantly lower total body bone mineral density when evaluated by DEXA scan putting them at risk for fractures. There is also an increased incidence of serious cervical spine disorders, including cervical stenosis, Arnold-Chiari malformation, and syringomyelia.
Approximately two thirds of infants with Noonan syndrome also have heart (cardiac) abnormalities at birth (congenital heart defects). In about half of such cases, affected infants have obstruction of the normal flow of blood from the lower right chamber (ventricle) of the heart to the lungs (pulmonary stenosis). In those with pulmonary stenosis, the heart must work harder to send blood to the lungs for oxygenation. The symptoms resulting from pulmonary stenosis will vary, depending on the severity of the stenosis and any other associated findings. In some severe cases, an affected infant's heart may begin to enlarge immediately after birth (i.e., upon initiation of breathing in the newborn). In such cases, the heart may be unable to pump blood effectively (heart failure) to the lungs and throughout the body. Associated symptoms and findings may include bluish discoloration of the skin and mucous membranes (cyanosis) due to abnormally low levels of circulating oxygen (hypoxia), breathlessness, swelling of the abdomen, feeding difficulties, and/or other abnormalities. Potentially life-threatening complications may result without appropriate treatment. In less severe cases of pulmonary stenosis, symptoms may not become apparent until later childhood. Such symptoms may include breathlessness, easy fatigability, and/or other abnormalities. In other cases, pulmonary stenosis may be mild and symptoms may not occur (asymptomatic).
In approximately 10 percent of infants with Noonan syndrome, there may be an abnormal opening in the fibrous partition (septum) that divides the two upper chambers (atria) of the heart (atrial septal defects). Another 10 percent of those with congenital heart defects may have enlargement (hypertrophy) of the partition that separates the left and right ventricles (interventricular septum) and, in some cases, of the left ventricular wall (hypertrophic cardiomyopathy). Less often, other congenital heart defects may be present (e.g., ventricular septal defects, patent ductus arteriosus, atrioventricular canal defect). According to the medical literature, most individuals with Noonan syndrome have a single heart defect. However, some affected individuals may have pulmonary stenosis in combination with either an atrial septal defect or hypertrophic cardiomyopathy, for example.
Atrial septal defects occur in approximately 10 percent of those with Noonan syndrome who have congenital heart defects. In the normal heart, a small opening is present between the two atria (foramen ovale) at birth. Shortly after birth, the atrial septum gradually closes and covers this opening. In infants with atrial septal defects, however, the atrial septum may not close properly or may be malformed during fetal development. As a result, the opening between the atria persists long after it should be closed, causing an increase in the workload on the right side of the heart and associated enlargement of the right ventricle, the right atrium, and the main pulmonary artery. The size, location, and nature of an atrial septal defect and any associated abnormalities determine the severity of symptoms.
Many children with atrial septal defects have no symptoms. However, in some cases, associated symptoms may include poor weight gain, mild growth delays, and an increased susceptibility to repeated respiratory infections (e.g., pneumonia) and bacterial infections of the lining of the heart (endocarditis) and the heart valves. In rare cases, severely affected children may also experience breathlessness, easy fatigability with exercise, heart failure, and/or irregular heartbeats (arrhythmias).
Approximately 10 percent of affected infants with heart defects experience hypertrophic cardiomyopathy. In most cases, such abnormal enlargement (hypertrophy) affects a localized area of the fibrous partition separating the left and right ventricles (anterior interventricular septal hypertrophy); in other cases, the entire septum and the wall of the left ventricle may be affected. Hypertrophic cardiomyopathy may cause reduced cardiac output. Associated symptoms and findings may include fatigue, brief fainting episodes (syncope) during exertion or exercise, and heart failure. Without appropriate treatment, life-threatening complications may result in some cases. Patients with NS with HCM have a worse risk profile at presentation compared with other children with HCM, resulting in significant early mortality (22% at 1 year). Hypertrophic cardiomyopathy can also develop later in life.
Some infants with Noonan syndrome may also have malformations of certain blood vessels, such as the presence of abnormal passages (fistulas) involving the arteries that supply blood to heart muscle (coronary arteries). The coronary arteries may also be dilated (ectatic) and/or curved (tortuous) in contour. In addition, some affected infants may have malformations of certain lymph vessels (congenital lymphatic dysplasia). Lymph, a bodily fluid that contains certain white blood cells (lymphocytes), fats, and proteins, accumulates outside blood vessels in spaces between cells in tissues and flows back into the bloodstream via lymph vessels. In some infants with Noonan syndrome, lymphatic system malformations may include underdevelopment (hypoplasia) of certain channels within lymph tissue through which lymph enters lymph vessels; abnormal widening (dilatation) of lymph vessels within the lungs (pulmonary lymphangiectasis); and/or widening (dilatation) of intestinal lymph vessels (intestinal lymphangiectasis), particularly the vessels that transport chyle, the milky fluid that is absorbed from food during digestion. Intestinal lymphangiectasis may result in loss of protein during intestinal absorption (protein-losing enteropathy), abnormally low levels of certain circulating white blood cells (lymphopenia), and loose, foul smelling stools that contain an excessive amount of fat (steatorrhea).
In utero, some affected infants may have an abnormal cystic swelling beneath the skin in the neck area (cystic hygroma). There may, in addition, may more fluid around the baby than usual (polyhydramnios). Due to lymphatic system malformations and associated obstruction of normal lymph flow into the bloodstream, affected infants may have an abnormal accumulation of lymph fluid in certain tissues (lymphedema). In some cases, edema may affect tissues and cavities throughout the body (hydrops fetalis).
Approximately 20 to 33 percent of individuals with Noonan syndrome also have various blood clotting defects (coagulation factor deficiencies), low levels of circulating platelets in the blood (thrombocytopenia), and/or improper function of blood platelets. Platelets are specialized blood cells that help prevent and stop bleeding. Affected individuals may have low levels of certain substances in the blood (coagulation factors) that are essential in the normal blood clotting process, a complex process that is necessary to stop bleeding (hemostatis). In individuals with Noonan syndrome, such deficiencies may include low levels of coagulation factor XI and/or, in some cases, factors XII and/or VIII. In some cases, affected individuals may have von Willebrand disease, an inherited condition characterized by deficiency of coagulation factor VIII, prolonged bleeding time, and impaired adhesion of platelets. In addition, in rare cases, affected individuals' urine may have an abnormally "fishy" smell (trimethylaminuria), a finding that may be associated with platelet dysfunction. Due to coagulation factor deficiencies, platelet dysfunction, and/or thrombocytopenia, affected individuals may have a history of abnormal and easy bruising and bleeding. They should avoid aspirin-containing medications.
Some individuals with Noonan syndrome may also abnormal skin discolorations. In approximately one quarter of affected individuals, pigmented moles (nevi) may be present. In rare cases, there may be pale tan or light brown patches (café-au-lait spots) and/or black, darkish tan, or brown "freckle-like" spots (lentigines) on the skin.
Up to 35 percent of individuals with Noonan syndrome may also have mild intellectual disability. However, many affected individuals have a normal I.Q. (intelligence quotient). A recent study has shown that children with NS can have a specific impairment in the global processing of visuospatial information even with overall normal cognition. In addition, affected individuals may experience abnormal delays in the acquisition of skills requiring the coordination of mental and muscular activity (psychomotor retardation), learning disabilities, and language delays that may potentially be due to hypotonia, difficulties speaking and/or, in some cases, mild hearing loss. A lowered speed of information processing and relatively intact functioning in other cognitive domains characterizes the cognitive profile of many adults with NS.
Noonan syndrome is an autosomal dominant genetic disorder caused by abnormalities (mutations) in several different genes, the main ones being: PTPN11, KRAS, SOS1 and RAF1. PTPN11 mutations have been found in approximately 50% of affected individuals; KRAS mutations have been found in fewer than 5% of those affected; SOS1 mutations have been seen in approximately 13% of people with Noonan syndrome and RAF1 mutations are observed in 3-17% of those affected. Additional genes associated with Noonan syndrome have been identified in a handful of cases: NRAS, BRAF and MEK1. Two conditions with overlap are newly described in association with mutations in SHOC2 and CBL.
Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary to cause a particular disease. The abnormal gene can be inherited from either parent or can be the result of a new mutation (gene change) in the affected individual. Approximately 30-75% of affected individuals have an affected parent. The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy. The risk is the same for males and females.
Noonan syndrome appears to affect more males than females and is thought to affect approximately one in 1,000 to one in 2,500 people. However, other reports indicate that the disorder may affect more than one in 1,000 newborns in the general population. Since Noonan syndrome was originally reported in 1883 (O. Kobylinski) and more thoroughly described in 1963 (J.A. Noonan and D.A. Ehmke), more than 500 cases have been discussed in the medical literature. Such cases include affected individuals from some large multigenerational families (kindreds) as well as isolated cases in which a positive family history has not been found. The range and severity of associated symptoms and findings may vary greatly from case to case (variable expressivity), including among affected family members. Because Noonan syndrome is extremely variable and therefore may be under- or misdiagnosed, it may be difficult to determine the true frequency of the disorder in the general population.
In some cases, Noonan syndrome may be suspected before birth (prenatally) based upon results of fetal ultrasonography, a specializing imaging technique in which sound waves are used to create an image of the developing fetus. A diagnosis of Noonan syndrome may be considered due to abnormal maternal serum triple screen, detection of excessive amniotic fluid surrounding the fetus within the amniotic sac (polyhydramnios), the presence of an abnormal cystic swelling consisting of dilated lymph vessels in the neck area (cystic hygroma), a structural heart difference, other fetal anomalies, and confirmation of a normal chromosomal makeup (karyotype). However, in many cases, Noonan syndrome is diagnosed at birth or early infancy based upon a thorough clinical evaluation, identification of characteristic physical findings, and a variety of specialized tests.
It is important to note that, in some cases, individuals who have only minor, subtle characteristics associated with Noonan syndrome may not receive a diagnosis. According to the medical literature, physicians who specialize in diagnosing and treating heart abnormalities (cardiologists) should suspect the possibility of Noonan syndrome in any individuals who have congenital pulmonary valve stenosis. Because Noonan syndrome may be difficult to confirm in such cases (particularly if there is no family history of the disorder), reports suggest that Noonan syndrome should be strongly considered as a possible diagnosis in any individuals with pulmonary valve stenosis and certain eye abnormalities typically found even in the more mild cases (e.g., ptosis, epicanthal folds, ocular hypertelorism). In addition, in such cases, all immediate (first-degree) relatives should be examined for mild facial abnormalities and cardiac defects potentially occurring in association with Noonan syndrome.
In many individuals with the disorder, certain advanced imaging techniques and laboratory tests may be used to detect, confirm, and/or characterize specific abnormalities that may be associated with Noonan syndrome.
Congenital heart defects that occur in association with Noonan syndrome may be detected and/or confirmed by a thorough clinical examination and specialized tests that allow physicians to evaluate the structure and function of the heart. Clinical examination may include a physician's evaluation of heart and lung sounds through use of a stethoscope. In mild asymptomatic cases of pulmonary stenosis, the condition may initially be detected through an abnormal heart murmur heard during such stethoscopic evaluation.
Specialized cardiac tests may include electrocardiography (EKG), echocardiography, and/or cardiac catheterization An EKG, which records the electrical activities of the heart muscle, may reveal abnormal electrical patterns (e.g., left axis deviation, left anterior hemiblock, deep S wave). During an echocardiogram, sound waves are directed toward the heart, enabling physicians to study cardiac function and motion. During cardiac catheterization, a small hollow tube (catheter) is inserted into a large vein and threaded through the blood vessels leading to the heart.
This procedure allows physicians to determine the rate of blood flow through the heart, measure the pressure within the heart, and/or thoroughly identify anatomical abnormalities. In addition, physicians may also closely evaluate respiratory (ventilatory) capabilities since associated heart defects may result in inadequate blood supply to the lungs and breathlessness.
Specialized blood tests may be performed to detect potential coagulation factor deficiencies and/or platelet dysfunction.
Molecular genetic testing of the associated genes is available to confirm the diagnosis and for prenatal diagnosis.
The treatment of Noonan syndrome is directed toward the specific symptoms that are apparent in each individual. Treatment may require the coordinated efforts of a team of specialists. Pediatricians, physicians who diagnose and treat heart abnormalities (cardiologists), physicians who diagnose and treat disorders of the blood and blood-forming tissues (hematologists), physicians who diagnose and treat disorders of growth (endocrinologists) and/or other health care professionals may need to systematically and comprehensively plan an affected child's treatment.
In some individuals with congenital heart defects, treatment with certain medications, surgical intervention, and/or other techniques may be necessary. In such cases, any surgical procedures performed will depend upon the location, severity, and/or combination of anatomical abnormalities and their associated symptoms. Cardiac, arteriovenous, and/or lymphatic malformations that may be present must be taken into consideration during decisions concerning surgical procedures. For example, during certain types of surgery performed on lymphangiomas, there is an increased risk that chyle may escape from the largest lymph channel in the body (thoracic duct) into the cavity between the neck and the diaphragm (thoracic cavity), potentially causing life-threatening complications (chylothorax).
For those who also have thrombocytopenia, platelet dysfunction, and/or coagulation factor deficiencies, physicians, dentists, and/or other health care workers may recommend certain preventive measures before or take certain supportive measures during surgery to prevent, lower the risk of, or control abnormal bleeding.
In addition, respiratory infections should be treated promptly and vigorously. Because of the potentially increased risk of bacterial infection of the lining of the heart (endocarditis) and the heart valves, affected individuals with certain heart defects may be given medication prior to any surgical procedures, including dental procedures, such as tooth extractions.
In affected males with cryptorchidism, surgery should be performed to move undescended testes into the scrotum and attach them in a fixed position (orchiopexy). Such surgery is typically performed between 12 and 24 months of age to help prevent the risk of associated infertility.
In addition, appropriate supportive measures may be used in affected individuals with lymphedema.
Early intervention may be important in helping children with Noonan syndrome reach their potential. Special services that may be beneficial to affected children may include special remedial education, speech therapy, physical therapy, and other medical, social, and/or vocational services. The short stature in patients with Noonan syndrome can be treated with growth hormone which has been shown to improve final adult height.
Genetic counseling will be of benefit for affected individuals and their families. In addition, as mentioned earlier, thorough clinical evaluations may be important in family members of diagnosed individuals to detect any symptoms and physical characteristics that may be associated with Noonan syndrome. Other treatment for the disorder is symptomatic and supportive.
Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Tollfree: (800) 411-1222
Email: email@example.com
For information about clinical trials sponsored by private sources, contact:
Contact for additional information about Noonan syndrome:
Amy E. Roberts, MD
Assistant Professor of Medicine
Harvard Medical School and Cardiovascular Genetics
Division of Genetics and Department of Cardiology
Boston Children's Hospital
Tel: 617-355-8794
Fax: 617-739-6282
Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder.
Allanson JE. Noonan Syndrome. In: The NORD Guide to Rare Disorders, Philadelphia, PA: Lippincott, Williams and Wilkins; 2003: 722-723.
Wilkinson JD, Lowe AM, Salbert BA, et al. Outcomes in children with Noonan syndrome and hypertrophic cardiomyopathy: A study from the Pediatric Cardiomyopathy Registry. Am Heart J. 2012;164(3):442-8.
Malaquias AC, Brasil AS, Pereira AC, et al. Growth standards of patients with Noonan and Noonan-like syndromes with mutations in the RAS/MAPK pathway. Am J Med Genet A. 2012 Aug 6. [Epub ahead of print]
Wingbermühle E, Roelofs RL, van der Burgt I, et al. Cognitive functioning of adults with Noonan syndrome: a case-control study. Genes Brain Behav. 2012 Jul 11. [Epub ahead of print]
Briggs BJ, Dickerman JD. Bleeding disorders in Noonan syndrome. Pediatr Blood Cancer. 2012;58(2):167-72.
Baldassarre G, Mussa A, Dotta A, et al. Prenatal features of Noonan syndrome: prevalence and prognostic value. Prenat Diagn. 2011;31(10):949-54.
Tartaglia M, Gelb BD, Zenker M. Noonan syndrome and clinically related disorders. Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):161-79.
Romano AA, Allanson JE, Dahlgren J, et al. Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics. 2010;126(4):746-59.
Pierpont EI, Pierpont ME, Mendelsohn NJ, Roberts AE, Tworog-Dube E, Seidenberg
MS Genotype differences in cognitive functioning in Noonan syndrome. Genes Brain Behav. 2009;8(3):275-82.
Noordam C, Peer PGM, Francois I, De Schepper J, van der Burgt I, Otten BJ . Long-term GH treatment improves adult height in children with Noonan syndrome with and without mutations in protein tyrosine kinase phosphatase, non-receptor-type 11. Eur J Endocrinol. 2008;159: 203-6.
Osio D, Dahlgren J, Wikland KA, et al. Improved final height with long-term growth hormone treatment in Noonan syndrome. Acta Paediatr. 2005;94:1232-7.
Allanson JE, Roberts AE. (Updated August 4, 2011). Noonan Syndrome. In: GeneReviews at GeneTests: Medical Genetics Information Resource (database online). Copyright, University of Washington, Seattle. 1997-2012. Available at http://www.genetests.org. Accessed September 20, 2012.
DYSCERNE – Noonan Syndrome Guideline Development Group. Management of Noonan syndrome: a clinical guideline. University of Manchester, 2010. Available at: http://www.dyscerne.org/dysc/digitalAssets/0/265_Noonan_Guidelines.pdf. Updated February 15, 2011. Accessed September 20, 2012.
The information in NORD's Rare Disease Database is for educational purposes only and is not intended to replace the advice of a physician or other qualified medical professional.
The content of the website and databases of the National Organization for Rare Disorders (NORD) is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD. Individuals may print one hard copy of an individual disease for personal use, provided that content is unmodified and includes NORD's copyright.
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text:
Oaky, Full-Bodied Wine Cellars
Boasting such amenities as African zebrawood wine racks and a stained-glass window, these cellars are big selling points
$32 Million
Annapolis, Md.
Seven bedrooms, eight bathrooms, 26,000 square feet
This austere 350-square-foot wine cellar fits in with the rest of the Georgian brick estate, a former Capuchin monastery. The wine cellar, which can store up to 1,800 bottles, is dimly lit and has a stained-glass window from the home's original chapel. The estate also has a ballroom, a conservatory, a 60-foot infinity pool and a guesthouse.
Listing agents: Maria-Victoria Checa and Dave DeSantis of Sotheby's International Realty.
$29.5 Million
Woodside, Calif.
Four bedrooms, 5½ bathrooms, 14,000 square feet
Owner Doug Kampcik says he dug through the French country-style home's sandstone foundation to install the 800-square-foot wine cellar, which has granite flooring, redwood racks and capacity for 13,200 bottles. The home includes a movie theater, a gym, a guest cottage and a management system that controls heating and air-conditioning.
Listing agent: Anna Pennington Boucher of Sotheby's International Realty.
$58 Million
Beverly Hills, Calif.
Seven bedrooms, 11 bathrooms, 48,000 square feet
This 1,100-square-foot dine-in wine cellar—with white oak flooring, mahogany and African zebrawood wine racks, hand-carved glass and a hand-cut crystal chandelier—seats eight and can hold 5,000 bottles. The French chateau-style estate includes a grand ballroom, an indoor pool, an outdoor pool and a Moroccan meditation room.
Listing agents: Stacy Gottula and Joyce Rey of Coldwell Banker—Beverly Hills South.
—Sanette Tanaka


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Auburn Tigers fan Katy Reynolds takes a photo of the poisoned oak trees near Auburn University at Toomer's Corner in Auburn, Ala., earlier this week. The landmark trees have yellow and brown leaves and bare spots, but several experts say it is still too early to determine whether they will survive an attack that police allege was carried out by a University of Alabama fan who is currently awaiting trial.
MONTGOMERY, Ala. (AP) -- An Alabama fan is about to go on trial on charges of poisoning two oak trees that are fixtures for fans of archrival Auburn.
Attorneys will begin picking a jury in Lee County on Tuesday for the case against 63-year-old Harvey Updyke Jr. The courthouse is less than 10 miles from the Toomer's Corner oaks and Auburn's campus.
Updyke and wife Elva were in court Monday for the deposition of an expert witness who is unavailable later in the week.
Updyke is a former Texas state trooper and a longtime Crimson Tide fan. His trial has been delayed several times since his indictment in May 2011.
Prosecutors say Updyke poisoned the trees after Auburn's victory over Alabama during the Tigers' 2010 national title season. Updyke has pleaded not guilty.


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Lil' Squirt Tees > Lil Squirt Tees > Mom/Family Tees > All I Wanted Was A Back Rub > All I Wanted Was A Back Rub Value T-shirt
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