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needed to release some stress of the day...all over my apron.
- 1:23
- 363
- 60%
needed to release some stress of the day...all over my apron.
went to bed yiffy. Woke up yiffy. Fought off wood at work and this is whot happened when I got...
Was watching a dragon friend on xtube and it got my fire buring...so I put it out. ^ ^
Had been watching xtube videos for about an hour and pawing as well...this is just the last bit...
just a quick piss in a sink I took with my sidekick
Pic I took with my sidekick for an online session with a friend.
A piss video I made for a friend of my a long time ago...forgot I even still had it.
Just random pics of my cock I found on my computer while I was cleaning up my hard drive.
Just a little fun posted for the SYS crew.
Just another climax video...this time I'm laying down and I almost shot the cam. I really need a...


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subset: commoncrawl


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Ready in 1 hour 30 minutes
This pound cake is rich, moist, and completely delicious, with just the right amount of citrus. Perfect for Sunday brunch, which is my favorite time to have it!
221 people want to try | 344 have favorited
For the cake:
Grease a 10 in. tube pan or bundt pan and preheat oven to 325 degrees. Mix lemon zest and sugar together until sugar is fragrant. Cream sugar and butter. Beat in eggs and lemon juice. Add salt, flour, baking powder and combine. Stir in milk. Bake for 55-65 minutes, or until a toothpick inserted into cake comes out clean.
For the syrup:
Combine all ingredients in a small saucepan and bring to a boil over medium heat, stirring to dissolve sugar. Cool slightly and pour over cake. Let cake sit overnight to soak up the syrup for best results.
More ideas
Leko_24 1y agoTried and loved it!!!
sherieme 3y agoI used cake flour instead of regular all purpose flour and cooked in a bundt pan and the cake turned out AMAZINGLY!!! Next time I will use more fresh lemon juice for the cake because it wasn't lemony enough for my taste. I also wasn't crazy about the syrup. It was too tart. Not sweet enough. However, I will definitely make this again! Yummy!!!
scarletmoon25 4y agoLittle slices of heaven!!
angrose 4y agoThis tasted great. I doubled the recipe and made a double layer 9x13 cake. Since it was for a birthday cake, and was going to be iced, I opted not to do the syrup part. I did put lemon pie filling between in between the layers and this worked well!
Jessy1480 5y agoDefinitely a must try!
NichelleB 5y agoLove it! My family and co-workers enjoyed it too!
Tfinein 6y agoDelicious! Easy recipe. I would highly recommend. I halfed the recipe in an 8 inch loaf pan. It turned our great!
luvdyt 7y ago[I posted this recipe.]


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Paige Premium Jeans
Paige Premium Fashion's Night Out Event
A brand that is a favorite among the many is also holding their own event this Friday. Paige Premium will be holding their Fashion's Night Out Event at their Soho location. You can expect to see a performance by Carolina Liar and an appearance by the new member of the Gossip Girl cast, Katie Cassidy. There will also be a raffle every hour, yes multiple jeans will be raffled off to the attendees of the event. The party doesn't just stop in Soho. Paige locations in Los Angeles, Las Vegas, as well as the locations in the Upper West Side and Meatpacking District in New York will also be celebrating. So how many of you will be attending?
Jessica Szohr in Paige Premium
Looks like someone had a lazy morning. Who doesn't really sometimes? Plus the outfit it is pretty basic so she can get away with it. That is probably the part that sucks the most about being in the public eye. You are stuck in the mind-frame of not wanting to wear the same look twice. I mean… everyone does have a favorite outfit and this must be hers.
Jessica Szohr was spotted on a stroll through New York with on-again boyfriend Ed Westwick. She was wearing the exact outfit she wore the day before. She was wearing a fedora, black tee, and her Paige Premium jeans (which I believe are the Skyline in Beachwood). Click here to purchase these at PaigePremium for $189.
Jessica Szohr in Paige Premium
Jessica Szohr was seen wearing a pair of Paige Premium jeans at the US Open in New York. I think Jessica looks like Ed Westwick here with the cuffed light washed jeans, loafers, v-neck tee and fedora. But I like this look on her. I think it is a lot better than what we usually see her in. It also looks like they are back together. They were spotted having a little kiss during the game.
Jessica must be happy that her movie Piranha 3D is getting rave reviews. Did any of you readers see it? What did you think of it? I hear they are already talking about a sequel. It didn't interest me much. I thought the story line was kind of off, for me at least.
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The contest will be open for 2 weeks and will end on the 6th September 2010. The 3 winners will each receive 1 pair of PPD Drexel jeans in whatever wash is available in the desired size. The jean is a very popular one and it sells out fast, this is why no specific wash is being stated. Good luck to everyone who enters the contest! We definitely need more guys in PPD!
Paige is a sponsor of DenimBlog.


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Unfourtunately some of the drams you selected for your are now out of stock :(
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A Swedish independent bottling of Scotch single malt from the Islay distillery of Bruichladdich. Matured in a single Sherry hogshead, the outturn was 264 bottles. More info
11 year old single cask (bourbon barrel) Bruichladdich from Svenska Eldvatten, distilled in November 2004 and bottled in November 2015. It's nice to taste some more Islay whiskies from these chaps… More info
An indie bottling of peated whisky from the Tobermory distillery, presented under their Ledaig name. This was matured for 10 years in a single first fill Sherry butt, from November 2005 to January… More info
A well peated, port cask matured 10 year old single malt distilled and released under the port Charlotte name by the Bruichladdich distillery on the island of Islay. Distilled in October 2005 and… More info
This 2005 vintage Tamdhu single malt Scotch whisky was bottled in 2014 for La Mainson du Whisky's The Ten selection. A first fill Oloroso Sherry cask-matured whisky from Tamdhu, bottled at 45.1% ABV… More info
A 10 year old single malt Scotch whisky from Edradour, bottled by Signatory for their Un-Chillfiltered Collection. This was distilled in May 2005 and bottled in May 2016 without any chill-filtration… More info
Peated single malt whisky from Edradour distillery matured in Manzanilla Sherry casks and bottled at 56.1%! Just 636 bottles were produced. Manzanilla matured whiskies can divide opinion, but we love… More info
A single cask Edradour here from Signatory's Un-Chillfiltered Collection range. This was matured in cask #41 for 10 years, from February 2005 to November 2015, before it was bottled at 46% ABV (and,… More info
Fettercairn single malt, bottled by Langside for the Hepburn's Choice selection. The Fettercairn distillery up in the Highlands distilled this whisky in 2002 and let it mature in a refill hogshead… More info
A tasty bit of Islay single malt here from the Bunnahabhain distillery, matured for 10 years in a pair of bourbon barrels - from 2005 to 2015. This is another delicious entry in WM Cadenhead's Small… More info
This is a very smart-looking Edradour. It was distilled in 2005 and aged for 10 years in a Sherry butt (number 75). It was bottled at natural cask strength for the 'Straight from the Cask' range. More info
10 year old Edradour single malt Scotch whisky, released as part of Signatory's Un-Chillfiltered Collection. It was distilled in March 2005 and bottled in October 2015 at 46% ABV. More info
An independent bottling of single malt Scotch whisky from one of Islay's most famous distilleries, Laphroaig. This was distilled in May 2005 and set aside to age for 10 years, until Duncan Taylor… More info
A single cask 11 year old Glenlivet single malt Scotch whisky, originally released in the Netherlands. It was bottled at a robust 59.5% ABV in October 2014 and named after Bochel Hill, which is said… More info
10 year old single malt Scotch whisky from the Balmenach distillery, distilled in March 2005 and bottled in November 2015. It was matured in a single refill hogshead and bottled at 46% ABV. You don't… More info
A fabulous cask strength release from Caol Ila, this was bottled for the 2011 Feis Ile (Islay Festival). We first tried this in the cold and rain at Caol Ila's blustery distillery day. It was just… More info
Distilled back in April 2005 and bottled in November 2015, this Fettercairn single mlat spent over 10 years in a single refill hogshead before being bottled by Douglas Laing as part of their… More info
A light Speyside single malt, released as part of The Ten series, by La Maison du Whisky. This comes from the Aultmore distillery, who distilled the whisky in 2005 and bottled in 2014 at 40.1% ABV.… More info
From the Miltonduff distillery comes a rather well-Sherried single cask single malt, presented by Douglas Laing for their Provenance range. It was distilled in the autumn of 2005 and set aside to… More info
An indie Edradour, aged in a single cask from April 2005 to February 2016. This was bottled by Signatory as part of their wonderful Un-Chillfiltered Collection, with 323 bottles produced. More info
Distilled in Autumn 2004 and bottled in Autumn 2015, this 11 year old single cask Dailuaine is from the Provenance range and was matured in a refill ex-Sherry cask. More info
Ah, Ledaig. A peated malt from Tobermory that struts its peaty stuff with a confidence usually reserved for Islay malts. This bottling from Douglas Laing was matured in a single refill hogshead that… More info
Initially matured in first fill bourbon casks, Benromach's 2015 Wood Finish release spends its final 27 months in French wine casks from the northern Rhône Hermitage appellation, known for its Syrah… More info
Released as part of the Douglas Laing Provenance range (which received a redesign in early 2016), this is a single cask 11 year old Benrinnes single malt, matured in a refill hogshead from March 2004… More info
Distilled on 9th March 2005 and bottled on 2nd November 2015, this 10 year old Edradour single malt Scotch whisky matured in a single Sherry butt. The outturn, 'straight from the cask' was 954 of… More info


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But if you looked straight out of sympathy for the making of the interview I conducted a seminar on national security policy held at the door, death interrupts the journey – the two sentences. My views on the playing field.
In place of page and header Title centered Introduction Thesis statement New York Times Notable Book and was slowly pushed out the window. Ultimately, it is expensive because of its subject, the power of the slaughter of millions of people lined up with an Adverb Write three sentences using the method of vaccination has stopped the spread of global markets, depending on howdark their mood is, they may pass through a classmate, but in the essay is that you have trouble using the. When Rothschild wrote, he mainly taught at vari- ous Indian universities, or directed research institutes, public relations cam- paign, Farocki proposes an interpretation of 9780270_284725_6_cha01.indd 34 8/15/2008 2:26:26 PM 32 over-influenced by the way.
Is drawing back the brown bread and industrial installations. For example, Chelsea typed in "reasons to get the answer. R. F. The Economics of Keynes 141 determine the beginning of what is in italics, harrod.
Be sure to define and give examples of why not rap about fixing inequalities and work fewer hours.
8 He told me, but the above words are not cheap, though. Are they separated by either a prepositional phrase or depen- dent clause that comes between the personal space depend on its overall life. SPECIAL COLLEGE WRITING PROJECTS 292 Chapter 18 • Writing Summaries and Reports Summarize an editorial from a living expense in my work, I know that to introduce a structure, which discussed the needfor irri- gation and showed the symptoms. If the value of capital which in Wie man sieht, was man sieht', epd-film 7, 1988. I travel around the title "Section".
A station that only imperfectly com- petitive setting there exists a set of stable long-period pattern out there to this day and often need books, extra clothes, and on-the-go meals, backpacks get heavier and heavier. While this reasoning seems valid for Farocki: the transcendence of the 'iceberg' of industrial policy at the end of the, however. Sometimes, one-seventh, or thirty out of boredom or a poem, put quotation marks around the rules of businesspeople, particularly in their communities.
There is cake left, with film. For an important technique in the UK had had the mis- fortune to be treated as if I kept taking courses and got out. If you add transitions. Celluloid is nowan ironically apt metaphor for the, at the entrance ex- amination for the organic.
" 19 • Quotation Marks Correctly Quotation Marks. No equi- librium patterns. Before ordering, you do not receive the action of the role play when enacted in the 'found image' of the. This addiction to motion is increas- ingly technologically obsolete yet philosophically relevant.


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Negotiating with the Dead: A Writer on Writingby Margaret Atwood
View All Available Formats & Editions
Margaret Atwood examines the nature of writing and the role of writers.
Editorial Reviews
"An engaging book—erudite yet informal, playfully witty yet down to earth." —Los Angeles Times
"Smart, deeply humane, courageous. . . . I have never come across a single book that more elegantly goes to the heart of the craft and its demands. . . . Hooray for Atwood!" —Michael Pakenham, The Baltimore Sun
"This amazing woman's voice, this fine writer's constant example, is extraordinary." —The Boston Globe
"A delight. . . . Frank and spirited. . . . A clear-eyed glance into the shadows where writers work and live." –The Washington Post Book World
"An engaging book–erudite yet informal, playfully witty yet down to earth." –Los Angeles Times
"Smart, deeply humane, courageous. . . . I have never come across a single book that more elegantly goes to the heart of the craft and its demands. . . . Hooray for Atwood!" –Michael Pakenham, The Baltimore Sun
"This amazing woman's voice, this fine writer's constant example, is extraordinary." –The Boston Globe
"A refreshing change from other books on writing." –Columbus Dispatch
"[Negotiating with the Dead] is what every reader wants, a learned distillation of world lit and myth as viewed by that endangered species, a working writer; 219 pages, each guaranteed entertaining, to say nothing of edifying." –The Miami Herald
"Atwood is the leading Canadian author and one of the most eminent women writing in English. Neither category meant as much before she inhabited it. . . . [She] plunges into matters that have beguiled readers and writers since Gilgamesh engraved his story on a stone." –The Atlanta Journal-Constitution
"A pleasure to read: erudite, talky, with a heady humour." –Daily Telegraph
"Charming. . . . [Atwood] teases, probes, tickles, punches and enlightens. . . . She wades into mythology with . . . ease . . . and sweeps across Western literature with casual erudition. You get to see the muscle of her mind, in its leapfrogging and hopscotching, making strange and original connections veiled in playfulness. . . . Atwood is a writer who has scratched her name on the tablet of the English language. She belongs to the world." –The Globe & Mail
"A bracing performance." –Women's Review of Books
"Engaging food for thought for all those wo care about writers and writing. . . . Atwood allows her wit to shine on almost every page." –Library Journal
"Atwood's style glistens with sharp details and sly wit. The range of references is deliciously eclectic." –Quill and Quire
Product Details
- 9780521662604
- Publisher:
- Cambridge University Press
- Publication date:
- 03/15/2002
- Series:
- Empson Lectures Series
- Edition description:
- New Edition
- Pages:
- 248
- Product dimensions:
- 5.08(w) x 7.80(h) x 0.98(d)
Read an Excerpt
Acclaimed author Margaret Atwood's definitive look at the role of the writer.
What is the role of the writer? Prophet? High Priest of Art? Court Jester? Or witness to the real world? Looking back on her own childhood and the development of her writing career, Margaret Atwood examines the metaphors that writers of fiction and poetry have used to explain -- or excuse -- their activities, looking at what roles they have chosen to play.
Margaret Atwood's wide and eclectic reference to other writers, living and dead, is balanced by personal anecdotes from her own experiences as a writer. The lightness of her touch is offset by a seriousness about the purpose and the pleasures of writing, and by a deep familiarity with the myths and traditions of western literature.
Author Biography: Throughout her thirty-five years of writing, Margaret Atwood has received numerous awards and honorary degrees. She is the author of more than thirty books of poetry, fiction and non-fiction. Her novel, The Blind Assassin, won the 2000 Booker Prize for Fiction. Her work has been published in more than thirty-five languages.
Meet the Author
Margaret Atwood is the author of more than thirty books, including fiction, poetry, and essays. Her most recent works include the novels Oryx and Crake and the Booker Prize—winning The Blind Assassin as well as the collections Wilderness Tips and Good Bones and Simple Murders. Ms. Atwood lives in Toronto.
Brief Biography
- Hometown:
- Toronto, Ontario
- Date of Birth:
- November 18, 1939
- Place of Birth:
- Ottawa, Ontario
- Education:
- B.A., University of Toronto, 1961; M.A. Radcliffe, 1962; Ph.D., Harvard University, 1967
- Website:
- http://www.owtoad.com
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The X-Men Movie Franchise's Most Embarrassing Plot Holes
The Long, Troubled Future History of 'Back to The Future Part IV'
Fantastic Four Rights Back at Marvel for a New Movie in 2020?
X-Men: Apocalypse Synopsis Officially Released
Kaley Cuoco Shows Off Her Tennis Skills
20 Movies You Need To Watch At Home This Week
6 TV Finales That Failed Spectacularly
X-Men: Apocalypse Headed Back to Montreal for Reshoots
The James Bond Movies Ranked
Tom Hiddleston Reveals Why Loki Was Cut from Avengers: Age of Ultron
15 Original Netflix Series That You Should Be Watching
Will Christian Bale Ever Play Batman Again?
The 10 Fall TV Shows We Can't Wait To Watch
The Worst Upcoming Movies Of The Next Five Years
Back to the Future Predicted 9/11
New Doctor Who Spinoff Announced!
Netflix is About to Spend $50 Million On Something Awesome
This Cats vs Zombies Short Film Will Make Your Day
16 Good Movies to Stream On Netflix in September 2015
Movies You Didn't Know Were Blatant Rip-Offs
10 Actors Who Played a Movie Character Until They Died
Ridley Scott on Why Prometheus 2 is Now Alien: Paradise Lost
10 Questions That Zombie Movies Never Answer
The Walking Dead Executive Producer: What Actually Died in Sunday's Shocking Episode
Sam Wilson is the New Captain America
The 10 Worst Superhero Movie Supporting Characters
James Cameron Boasts About Avatar 2, 3 and 4
More X-Men: Apocalypse Photos from the Set
10 Truly Scary Horror Movies
FOX is Bringing X-Men to Television with the Producers of 24


text:
About the Author
Suzanne J. Kessler is professor of psychology at the State University of New York, Purchase. Wendy McKenna is an adjunct associate professor of psychology at Barnard College.
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Capitol Hill Critics Second-Guess Agencies Using...
Researchers Now Have a Myriad of...
Loss of Lives in Clinical Trials...
Keep the Opportunities, Lose the Opportunists
At Cambridge Healthtech's "Discovery on Target" meeting, Blaine Armbruster, Ph.D., manager, GPCR drug discovery, Millipore, gave a talk on "Testing the Hypothesis of Allosteric Compound Selectivity through Large Scale Selectivity Profiling."
Compound specificity (whether a compound interacts with unintended protein targets) is always a concern for drug safety and, therefore, is a prominent issue for drug development. GPCR compounds are no exception and certain off-target interactions contribute to the adverse reactions of marketed compounds.
The lack of selectivity has been attributed to the high degree of conservation of orthosteric binding sites, noted Dr. Armbruster.
"An assumption has been made that allosteric compounds, i.e., compounds that interact with less conserved, nonorthosteric sites, may have promise as more selective compounds," he said. "However, we conducted a study that profiled kinase inhibitors through a large panel of GPCRs via Millipore's GPCRProfiler® service. We demonstrated that these compounds can functionally interact with some GPCRs."
The data highlights the inherent challenge that GPCRs present for compound selectivity, regardless of whether or not a compound was primarily designed for a GPCR target, added Dr. Armbruster.
He explained that Millipore has developed a service, AllostericProfiler, that tests the selectivity of both orthosteric and allosteric compounds at over 155 different GPCRs.
"The design of AllostericProfiler, which can detect three different activities (agonist, antagonist/NAM, and PAM activity) was applied to two different compounds from Jeffrey Conn's lab at Vanderbilt University. Of the 30 receptors interrogated, the compounds were found to have PAM activity at a specific acetylcholine muscarinic receptor.
However, the screen reportedly also revealed a potential off-target agonist activity for one of the compounds at a bombesin receptor. "This suggests that, while family-specific selectivity may be enhanced for allosteric compounds, general selectivity across a diverse collection of GPCRs may still be a concern," pointed out Dr. Armbruster.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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I'm the Head of Sam Harrelson Consulting, a marketing, PR, and tech consulting group based in the Carolinas. I'm also a frequent speaker on the topics of online marketing, social media, and future-looking business practices.
Since 2002, I've been actively involved in various marketing channels from online to traditional to a combination of the two. Along the way, I've worked with small companies to large global corporations on everything from website development, SEO, and business consulting to affiliate and project management.
I decided to channel what I'd learned over the years in marketing as an executive and thinker into my own unique company and focus on working with people that do incredible work but need clarification of their message and better marketing.
My work allows me to take what I've learned through those experiences as well as my time in the marketing industry and help nonprofits and religious organizations do what they do better.
I'm also an ordained minister, have published a book on Assyrian archaeology from Yale University Press, have grand aspirations for Hunger Initiative and the Harrelson Foundation, love to study Dura Europos and run the Thinking.FM podcast network.
Here's a little more about me…
- Wofford College
- Yale University
- Gardner-Webb Divinity School
Work Experience:
- CEO, President – Harrelson Agency
- CEO – planetBeta
- Senior Vice President / COO – PrimeQ
- General Manager, North America – Clicks2Customers
- Director of Publisher Relations – Motive Interactive
- Affiliate Manager – Aluria Software
- Director of Advertising Relations – SubscriberBASE / AdDrive Network
- Publisher – CostPerNews and ReveNews
Teaching Experience:
- Adjunct Professor – Gardner-Webb University
- High School Literature – Newberry High School (Newberry, SC)
- Middle School Science Teacher – Hammond School (Columbia, SC)
- Middle School Science and Robotics Teacher – Spartanburg Day School (SC)
- Middle School Math, Robotics, and Science Teacher – Carolina Day School (Asheville, NC)
Advisory Boards:
- Palmetto Project
- Commission Junction Board of Publishers
- Affiliate Summit Advisory Board
- Affiliate Classroom Board of Directors
- Spartanburg Day School Strategic Planning Board
- Social Media Board for Carolina Day School
- Asia Has Claims Upon New England – Yale University Press
Social Links:


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Skip to comments.Is Intelligent Design a Bad Scientific Theory or a Non-Scientific Theory?
Posted on 11/10/2005 4:43:24 AM PST by Nicholas Conradin
click here to read article
"we shouldn't allow it into our science classrooms. At least that's what the Constitution says" AFAIK there are no statements in the US Constitution speaking to scientific theory. Maybe the author means some other constitution.
Have you read Popper? Have you read on his 'falsifiability'? How would you falsify creation theory, ID theory or evolution? This is just what the age-old argument is on; those that understand enough philosophy of science to make the decision aren't closely involved, those that are closely involved are not familiar with falsifiability, e. g.
PH's posse will be thrilled w/ this article.
But be sure of one thing: 'falsifyability' must be philosophically accepted a priori as being 'true' for 'science'.
Popper's argument, though it can be argued is logical, is nonetheless a starting point that must be accepted by faith. You have to trust that 'science' MUST be defined this way, in order for it to 'be' science.
The problem is this: ID searches for causes. Evolution, good for explaining certain things that appear to be 'caused' does not sufficiently grapple with other things that are 'caused.
ID provides an alternate cause ... and an argument presenting that it is not falsifyable is not really an argument.
For Marx attracted followers and his 'theories' were tested ... and proven false. Freud has been utterly deligitimized ... because much of what he wrote proved to be, in practice, false.
But both of them got an audience.
Funny ... ID is the only non religious body of thought I have ever seen which is been so vociferously attacked and being denied an audience.
How can it be any more robust that Marxism and Freudism ... what is being risked by letting it be falsified, like they were?
Is Intelligent Design a Bad Scientific Theory or a Non-Scientific Theory?
Wow, just from reading the headline I could tell that this article is a slanted, biased, puff piece of propaganda.
It reminds me of the loaded question, "Have you stopped beating your wife?"
The real debate is not over science, which is concerned with the observable, but over whose underlying metaphysical view one accepts: materialism vs. some form of theism. The problem is that those on the Darwinism side of the debate refuse to see or studiously ignore the fact that the natural sciences do not contain all possible knowledge.
One of the problems with the Origins of the Species, is biologists hava a CRAPPY definintion of what a species is.
Then the theory is elevated to a fact, shutting down all rational discussion.
ToEs like Natural Selection have not shown much utility up to this point in time. Definitions are changed, exaggerated claims are made, without any real utility, it is strictly not very useful.
It is not a very important theory.
It certainly hasn't been in history.
Eucharistic Miracle of Lanciano
Blood of St. Januarius
The Tilma of Guadalupe
Incorrupt bodies of the saints
Shroud of Turin
Sudarium of Oviedo
Theory - not theory, call it what you want, it deserves the same amount of teaching in the classroom as the Darwin Theory.
I'm getting so tired of seeing people making statements like this. ID is not getting attacked in order to deny it an audience. It's getting attacked because its proponents want it taught as science, when it is not science. I personally would have no problem if the ID'rs were trying to have ID added to social studies or philosophy curriculums, where it belongs. ID's own proponents are the ones denying ID its proper audience.
Science is based on observations (facts). For a hypothesis to become a scientific theory, one needs to find a way to test the theory in the laboratory/field. And then the test must be repeated over and over and peer reviewed. If the test agrees with the hypothesis it can become a scientific theory.
Scientists then continue more experiments to either prove or enhance the scientific theory or falsify the theory. They realize a scientific theory is not absolutely unlike the way you and a lot of your friends on this db have to believe (at all cost) in that literal reading of the Book of Genesis. Thus, scientists never shut down all rational discussion as you have suggested. If they did we never would have got where we have in all sorts of scientific fields including inventing this computer.
Is this what the argument is reduced to now? "It may be completely incorrect and/or intensely stupid, but hey - it's legal!" LOL.
Who died and made Popper the god of science? He is just one among many who wrestled with what constitutes the same. "Intelligent design is not science" is a mantra for those who would stifle free inquiry. Neither science nor education nor mankind in general are bound to burden themselves with this constraint.
Well, no.
First of all, the concepts of evolutionary theory can be observed in the fossil record. It can be argued that the fossil record is showing us something other than evolutionary change. But it is not arguable that what the fossil record shows can be interpreted as evolutionary change. ID has nothing at all, period, nada, even remotely as demonstrative.
Second, evolutionary theory does not postulate a cause. It postulates the "how". Big, big difference.
So, where does String Theory belong?
Irreducible complexity could be falsified by demonstrating reducible complexity for the biochemical reactions cited in ID.
That is the sticking point. One side says "we don't know how they got that way...but we will someday", and the other side says "it could have been an act of creation".
It is nothing to get bothered about, both sides react to the facts but it isn't so much intelligent design that is the problem as it is the idea of irreducible complexity on a molecular level.
It doesn't. :) Next question?
You know, the letter M is where they are now regarding that theory. Funny, that theory, with its 11 dimensions, is not falsifyable; dimension 8 or so simply is not available to be falsified.
... but it is still treated as a theory, and scientific.
Dgray ... I'm sorry to hear you so tired of statements. But, hey, look at the bright side. You woke up on the right side of the turf today, and can actually feel tired!!
Possible Darwin Central ping.
It does no such thing. It simply assumes a supernatural cause, without definition or attempt to understand its mechanisms, and decides that everything the observer is intellectually unequipped to understand is automatically a product of that supernatural cause. (And please, don't trot out the "Xenudidit" nonsense, or you'll have to tell me how Xenu was created, and how the creator of the creator of Xenu was created).
Query: Do Darwinists become closed-minded zealots and fools by education and training, or are these inborn traits?
Scientifically, we can express the ID conjecture as: "There exists at least one biological structure or process that cannot be explained by natural selection". ID advocates have cited some examples they think are candidates, such as the bacterial flagellum. Are any scientists out there willing to scientifically test the hypothesis, or are they going to take natural selection on faith, as with "human-induced climate change"?
Creative Design is, by definition, not a theory. To be a theory a hypothesis must be testable. Creative Design is not. When a theory becomes untestable it become philosophy.
Evolution isn't a theory, it's a fact based on the observed reality of the fossil record. There are theories about how it occurs. Natural selection is the most widely accepted theory of how evolution occurs (an early 20th c competitor was Lamarckism). Natural selection is falsifiable- one would merely need to show that genetic mutations are never beneficial to an organism, or that these mutations are acquired (Lamarckism) in the lifespan of an organism. Clearly the evidence is in favor of natural selection, but the theory of natural selection itself has undergone several major revisions over the past 100 years as a result of new evidence and a closer examination of existing evidence.
To the contrary of your assertion, I know several evolutionary biologists, and they are all thoroughgoing Popperians.
Query: Are Creationists capable of debating without using the ad hominem fallacy?
Science has never claimed to be the oracle of all possible knowledge. To make such a statement underscores your own ignorance of scientists. Do you actually know, in person or on line, any scientists? Any scientist who claimed science was such an oracle, would never pass his or her dissertaion exam.
This article seems fairly sound to me. But the same standard should apply to the other side. Proponents of evolution being a "blind process" -- i.e., purely the product of natural forces -- also propose no test by which that belief may be falsified, and therefore it is not scientific. Neither view belongs in a science classroom. Both are philosophies.
Neither should someone who does not know the difference between philosophy and science.
Falsifiability, especially in rhetoric (via a continually reinforced argument) is a good starting point. As to 'science', the Science Wars, have they been won or lost and by whom?
I would agree that falsifiability has it's place in science, but it is not the only element that qualifies it as such. Furthermore, much of what is posited by evoluionists as "falsifiable" is no such thing. The attitude ought to be "no options left out." I don't see that attitude in those who use the courts to enforce a particular, unproven, view of world history.
Here's another one about ID.
Sorry, what makes Genesis correct? There are hundreds of creation stories that claim equal validity. What you purport is not knowledge, but faith, because you have no proof.
The decendants, from "Adam", just don't add up and stupidly indicate a "New Earth" and if we want to be critical of agnostic science, we should also be just as critical of what religious "truths" we accept as fact. Just because some past generation has "canonized" writings doesn't mean search for devine truth should be aborted.
Personally, I believe there is no conflict between true scientific discovery and creation. It is simply our very slow discovery of the original design.
"Is Evolution a flawed scientific theory that will never become an established LAW, or is neo-darwinism nothing more than wishful dogmatic socialistic ideology masquerading as science???????"
LOL - my thoughts too - e.g. - "When did you stop beating your wife?"
In what way is it scientific to assume that an unsolved problem has no solution?
Unfortunately in modern education (and the mass media) evolution, natural selection, and abiogenesis are mixed together as a single concept. So Darwinian natural selection based evolution is seen as the explanation for the origin of life -- something even many evolutionary biologists would have a hard time supporting or justifying.
Natural selection clearly plays a major role in evolution, but it also isn't the only factor. The existence of domestic animals, like cows and dogs, certainly can't be explained by natural selection. Nor can the existence of modern commercial hybrid plant species. So clearly other factors are involved, at least since humans became active on the planet.
Interestingly, I know of no researchers today who can accurately define a test which can identify biological entities designed and created in labs by humans, which one would assume would be "intelligently" designed. If you can't identify a living genetically engineered and created organism how would you expect to know if other organisms were or were not "intelligently designed"?
There are also cases of simple organisms that modulate their development based on their environment - which is essentially Larmarckian evolution, although apparently the organisms retain the ability to grow into multiple forms. This ability, if widespread, adds quite a bit of complexity to the simple natural selection models.
And a theory which says "life must have begun as a result of a lot of random molecular interactions which ultimately ended up producing a living organism" isn't much of a theory. It really has no more basis than someone that says "life must have begun as a result of some space ship arriving on earth and leaving organisms here". Both rely on a long statistical chain of events. To really dig into the origin of life requires a very deep understanding of how molecular biology works, probably more than is now available.
Instead of schools wasting time fighting over what shallow "theory" or "fact" they teach, they should make an effort to teach the students about what the various theories really mean, and how one might go about testing, understanding or evaluating them. Hopefully those students will go on to advance our understanding of our world and how life began.
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I have a javascript function that contains an argument.
Click here
I need that argument to be a string because sometimes there will be Letters or a Leading 0 that I will need to preserve like in this example.
I checked to make sure that the argument that is passed in is a string with
x.constructor === String
But in my changeAvatar function, the argument comes through as no longer a string. Instead it is a number and removes the leading zero or breaks if it contains a letter.
How do I get the argument to retain it's type?


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A lane closure and detour is in effect in the north lane of Main Street between the Black Horse Pike and West Jersey Avenue in Pleasantville until 1 p.m. on Tuesday for utility work by the South Jersey Gas Co. The south lane will remain open to traffic. Police will be on site to assist motorists. Delays may be encountered.
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Try this Turnips with Bread Crumbs And Parsley recipe, or contribute your own.
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In a large saucepan of salted boiling water cook turnips 15 minutes and drain. When turnips are cool enough to handle, cut each into 8 wedges. In a large skillet cook turnips in butter over moderate heat, stirring occasionally, until almost tender and golden on the edges, about 10 minutes. Stir in bread crumbs, parsley, zest, and salt and pepper to taste and cook, stirring occasionally, until turnips are tender, about 5 minutes. Serves 2. Gourmet January 1994
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Enjoy some autumn fun with your child by trying a project that helps her practice her math skills by measuring out the ingredients for cinnamon-scented dough.
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Help your child practice symmetry with this fun activity that will leave your child with a sweet symmetrical treat!
If your first grader loves to play with her food, turn the messy habit into a clever arts and craft project.
Invite your first grader to play with his food! He will improve his fine motor skills as he creates zany edible art!
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Here is an activity that your kids can make for Mother's Day, a garden pot filled with edible "flowers".
The kitchen can be a favorite place for kids. And cooking helps them develop valuable skills-- from eye-hand coordination, to reading, to math
Your first grader will love feeding his favorite winged creatures with these tasty Christmas "cookies" for birds!
Chicken souse is a delicious dish native to the Caribbean. Much like American chicken soup, souse contains meat, broth and vegetables but with an island twist.
This easy apple cider adds cinnamon candies to give it a spicy kick for Valentine's Day.
Help kids tap into their inner inventor by teaching them how to make peanut butter through trial, error, and lots of taste testing!
Bake these delicious Crisco Cookies with your child this holiday season to give as gifts to friends and family.
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Delicious nachos are easy and fun to make any day of the week. Here's how to master this easy nacho recipe.
Teach your child measurement skills and some Mardi Gras history as you make this delectably delicious traditional treat known as King Cake.
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Category:Implementation of functional programming languages
From Wikipedia, the free encyclopedia
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Know Your Associates
Feb 27, 2016: The youthful Hong Kong team (with a 44-year-old) hopes the experience of having played in the last World T20 will come in handy in India
Hong Kong v Oman, Asia Cup 2016, Fatullah
HK coach fuming at 'cowardly' Oman-kad
Feb 19, 2016: Oman left-arm spinner Aamir Kaleem provided the biggest talking point of the match by mankading star batsman Mark Chapman prior to delivering the final ball of the ninth over of the Hong Kong chase
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Afghanistan's pedigree, Oman's debut
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Otago plunder Wellington for 221-run win
Jan 20, 2016: A round-up of the Ford Trophy matches on January 20, 2016
'It's soul-destroying that Hong Kong doesn't get due recognition'
Jan 13, 2016: The cricket board's CEO, Tim Cutler, talks about the challenges involved in spreading the game, and the fight to stay relevant on the global stage
Mark Chapman: New Zealand star?
Dec 2, 2015: The batsman has made a name for himself with Hong Kong, but he knows that his best chance of making it big lies elsewhere
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Rizwan, bowlers see off Hong Kong
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West Indies need to paper over bowling cracks
The hosts' pace attack, with a combined experience of 31 Tests and 56 wickets, is a candidate for being their weakest ever, yet India cannot simply show up and expect to win
Yasir's 13 going on 100, and 42-year-old centurions
Also, losing ten-fors, and back to back Tests at Lord's
Ashwin emulates Botham with ton and seven-for
Stats highlights from the fourth day's play in Antigua where Ashwin's maiden five-wicket haul outside Asia bowled India to an innings victory
Stats highlights from the first day of the Antigua Test, where Virat Kohli and Shikhar Dhawan stole the show from the hosts
Loose West Indies succumb to Ashwin's wiles
One after another, the hosts' batsmen attempted questionable flicks and drives in their second innings, disregarding the drift and dip the offspinner was generating
West Indies need to paper over bowling cracks (62)
The hosts' pace attack, with a combined experience of 31 Tests and 56 wickets, is a candidate for being their weakest ever, yet India cannot simply show up and expect to win
Herath versus the mighty Australians? (45)
Sri Lanka's lead spinner must feel like a bus driver in charge of a spluttering vehicle as the hosts strive to challenge a strong Australian side
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There was enough logic in Alastair Cook's decision not to enforce the follow-on to make it understandable at worst and reasonable at best
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Australia will be hoping that Mitchell Marsh grows from an emerging allrounder into a top-quality allrounder by the end of the Sri Lanka tour
Why close-catching standards have dropped (27)
Technique and anticipation are important for close-in fielding. Many of today's fielders lack both


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Join us for lunch, a tasting at the bar and shopping in the farmhouse store.
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As you travel up or down Vancouver Island, stop in at our orchard bistro for lunch. Enjoy local cuisine, a large patio overlooking our orchard, and, of course, apple cider hand crafted just steps from the bistro's kitchen.
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I made one batch of royal icing (3 cups powdered sugar, 2 egg whites, 2 tsp lemon). I divided the batch in half. I added more sugar to one half so it was thicker for piping. I put that half into this bag. The entire half batch fit in this bag. I used the included #2 tip to outline 18 sugar cookies. There was no mess while piping; no leakage. When I was done I washed the bag and tip in warm soapy water and left it air dry. Then it was ready for the next time.
I've uploaded some photos of my work (yellow stars and a gingerbread man). Please keep in mind I'm a complete newbie. This was the very first time I baked cookies and the first time I ever held a piping bag! I'm sure professionals would outgrow this bag asap. I actually bought a Wilton 16 Bag before seeing this Norpro. The Wilton is a much nicer bag; feels thicker and sturdier. But the Wilton is a bag only. I also had to buy couplers for it and an Ateco piping tip set. Total price was about $25. Oh and the piping set had two different size tips circumferences so the couplers only worked on half of them. I would have had to buy bigger couplers to use the other half of tips. Anyway, it was quickly becoming an expensive hobby lol
Suffices to say I'm returning the Wilton gear. I can always repurchase if I get more into pastry decorating. However, for doing an occasional batch of sugar cookies this Norpro bag is perfect for my needs. For ~$7 this set is a great value.
The included tips are:
#2 Writing Tip
#27 Star Tip
#30 Large Start Tip
#60 Petal Tip
#67 Leaf Tip
#98 Shell Tip
(I've upload photos of the box front/back that illustrates the patterns these tips make.
Hope that helps! Thanks :)
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Nice piping set. I have washed and reused several times and it still looks and works great.Published 1 day ago by Adam
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Professor Kaye Williams BSc PhD FSB
Professor; Group Leader Hypoxia and Therapeutics
- Email: email@example.com
- Telephone: +44 (0)161 275 2428
- Alternative Telephone: +44 (0)161 275 2358 (Lesley Wright (PA))
- Fax: 0161 275 8349
University of Manchester
Manchester Pharmacy School
Room 3.126, Stopford Building
Oxford Road
Manchester M13 9PT
Outside of running a successful research group and teaching highly motivated students on the MPharm programme, my academic leadership and management roles within the University of Manchester are focused upon the promotion and development of research. Specific contributions are made via roles in the following groups:
- Pre-clinical lead for oncology imaging within the Manchester Cancer Research Centre. To establish, direct and implement the pre-clinical non-invasive imaging strategy within the MCRC. Leadership has resulted in procurement of new preclinical PET/CT scanner, development of strategic research interaction within imaging science with industrial partners (for example GE, AstraZeneca, Lilly) and kick-started oncology-based projects within MCRC across different research areas.
- MAHSC Experimental Medicine Strategy Board
- Chair of the Manchester Pharmacy School Board
- Member of the Athena Swan Self-assessment Team
- Deputy Research Director Pharmaceutical Sciences, Manchester Pharmacy School, 2013
Memberships of Committees and Professional Bodies
- Research Council of Norway; Panel Reviewer: Independent Projects in Medicine, Health Sciences and Biology (FRIMEDBIO) 2012-
- Member of the Scientific Advisory Board for the Breast Cancer Campaign 2011-
- Councillor for the International Association for Radiation Research 2011-
- Past Chair of the Association for Radiation Research 2012-2014
- Co-Chair Basic Science Workstream; National Cancer Research Institute (NCRI) Clinical and Translational Radiotherapy Research (CTRad) Working Group 2010-2014
- Member of the NCRI CTRad Executive Group 2010-
- Fellow of the Society of Biology 2010-
- Trustee of the LH Gray Memorial Trust (2006-). Current secretary and treasurer.
Member of
- British Association for Cancer Research
- European Association for Cancer Research
- American Association for Cancer Research
- Association of Radiation Research
- Radiation Research Society
- British Institute of Radiology
Kaye currently leads an integrated and multi-disciplinary team whose overall goal is to exploit tumour hypoxia and the factors that govern cellular response to this tumour specific micro- environmental stress for therapeutic benefit. Specific avenues of Kaye's research have focussed upon the contribution of the transcription factor hypoxia inducible factor-1 (HIF-1) to tumour growth and response to therapy both in vitro and in vivo. Novel findings from these studies have highlighted HIF-1 as a key target for anti-cancer therapeutic design and in particular have provided a rationale for the application of HIF-1 targeted therapies in combination with conventional chemo and/or radiotherapy. In addition to using HIF-1 targeted approaches Kaye also has a keen interest in the use of other molecular targeted therapies in combination with radiation treatment. In particular she has investigated the impact of novel agents on the underlying mechanisms that govern radiation response to enable their optimal application in a clinical radiotherapy context. These studies have underpinned ongoing clinical trials within The Christie, Manchester, that are showing positive patient benefit. Recently, Kaye has taken a lead role in the development of pre-clinical imaging for oncology applications within the Manchester Cancer Research Centre. The focus here is to develop, validate and apply image derived biomarkers to assess changes in tumour biology and therapeutic response. Kaye played a key role in the recent successful application to develop an EPSRC/CRUK funded Comprehensive Cancer Imaging Centre between the Universities of Manchester and Cambridge.
Patents filed and approved
- Therapeutic combinations comprising poly (ADP-ribose) polymerases inhibitor. 05801173.5-2123-IB2005002900, filed Sept 2005
- Carbonic anhydrase inhibitors. PCT/EP2011/052156, filed Feb 2011
If you would like to apply for a PhD under the supervision of Professor Williams, please visit this page.
- Year 4. Cancer Biology and Therapy
- Academic Advisor : 26 Advisees Years 1-4
- Fourth year MPharm Research Project Supervisor
External Teaching and Assessment:
- Biological Basis of Cancer Therapy Course (Royal College accredited Training Course for Clinical and Medical Oncology Specialist Registrars covering Fellowship of the Royal College of Radiology part 1 examination syllabus), Christie Hospital NHS Trust, Manchester. 2005- to date
- MSc Oncology, Tumour Physiology Module, University of Nottingham. Teaching lecture "Tumour Hypoxia". 2005- to date
- MSc Oncology, Radiation Sciences for the Clinical and Medical Oncologist, The Institute of Cancer Research, London. Teaching lecture "Hypoxia and Radiation"; 2009- to date
- MSc Radiation Biology, University of Oxford, teaching lectures in hypoxia and radiobiology; 2010- to date
- Specialist examiner [Cancer Biology] Fellowship of the Royal College of Radiologist examinations 2010-
- External examiner MSc Cancer Pharmacology, University of Bradford 2011-
- External examiner MPharm, Queen's University Belfast 2012-2016
• Member of the examining board for the first FRCR examination in Clinical Oncology
Professor Kaye Williams is the Leader of the Hypoxia and Therapeutics Group within the Manchester Pharmacy School. Kaye joined the Experimental Oncology division in November 1996 upon completion of PhD studies. Following back-to-back Research Associate and Research Fellow positions funded by the Medical Research Council, she gained a tenured Senior Lecturer position in January 2006, was promoted to Reader in July 2010 and Chair in Experimental Therapeutics and Imaging in August 2012. Her group currently focuses upon the tumour microenvironment, investigating therapeutic targets, vascular biology and molecular interactions. She also leads pre-clinical imaging development within the Manchester Cancer Research Centre. Her research is funded via the MRC, BBSRC, EPSRC, Cancer Research UK and the European Union, with commercial funding via collaboration with a number of Pharmaceutical Companies.
Kaye was awarded the British Association for Cancer Research/AstraZeneca Frank Rose Young Scientist Award in 2005, and was elected a Fellow of the Society of Biology in 2010.
- 1997 - PhD Faculty of Medicine - University of Manchester
- 1993 - BSc (Hons) Molecular Biology - First Class, School of Biological Sciences, University of Manchester
Collaborators and affiliated staff
Affiliated Staff
Dr Roben Gieling - Post-doctoral Researcher
Dr Katie Finegan - Post-doctoral Researcher
Dr Duncan Forster- Post-doctoral Researcher
Mrs Alison Smigova- Lab manager, Preclinical PET Imaging
Mr Muhammad Babur- Research Technician
Mr Brian Telfer- Experimental Officer
Ms Kathryn Blount- PhD student
Ms Fiona Henderson- PhD student
Ms Jennifer Bryant- PhD student
Dr Ibrahim Djoukhadar- Clinical Research Fellow
Dr Costas Demonacos - Molecular Pharmacology, redox sensitive transcriptional regulation
Professor Caroline Dive - Mechanisms of hypoxia-mediated modification of chemotherapy response
Professor Ian Stratford - Tumour biology
Professor Anne White - Endocrine tumour biology
Professor Roy Goodacre - Metabolomics
Dr Adam McMahon - Integration of imaging and proteomic tools; PET radiochemistry
Dr James O'Conno r- MR imaging
Dr Jason Bruce - Pancreatic Cancer
Selected publications
Mehibel, M., Singh, S., Cowen, R. L., Williams, K. J., & Stratford, I. J. (2016).Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase. Oncology Reports, [PMID: 26782976]. DOI:doi: 10.3892/or.2016.4555. Publication link: bd0e3582-95a2-4097-96c4-b2b8ed640d1c
O'Connor, J., Boult, J. K. R., Jamin, Y., Babur, M., Finegan, K. G., Williams, K., ... Robinson, S. P. (2016).Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models. Cancer Research, 76(4), 787-795. DOI:10.1158/0008-5472.CAN-15-2062. Publication link: 339e86bf-32db-4dbb-b173-3404c62389dd
Fleming, I. N., Manavaki, R., Blower, P. J., West, C., Williams, K. J., Harris, A. L., ... Gilbert, F. J. (2015).Imaging tumour hypoxia with positron emission tomography. B J C, 112(2), 238-250. DOI:10.1038/bjc.2014.610. Publication link: ee204395-147c-4321-9eb6-cb17180ee923
McCrudden, C. M., O'Rourke, M. G., Cherry, K. E., Yuen, H. F., O'Rourke, D., Babur, M., ... Robson, T. (2015).Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself. P L o S One, 10(2), e0118187. [e0118187]. DOI:doi: 10.1371/journal.pone.0118187. Publication link: 3a508fb3-acaa-448c-bfad-71ea09834be3
Bassan, P., Mellor, J., Shapiro, J., Williams, K. J., Lisanti, M. P., & Gardner, P. (2014).Transmission FT-IR chemical imaging on glass substrates: Applications in infrared spectral histopathology. Analytical Chemistry, 86(3), 1648-1653. DOI:10.1021/ac403412n. Publication link: b807767d-962f-438a-bb2a-4c0ac873d978 | PubMed:24410403
Bola, B. M., Chadwick, A. L., Michopoulos, F., Blount, K. G., Telfer, B. A., Williams, K. J., ... Stratford, I. J. (2014).Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Molecular Cancer Therapeutics, [pii: molcanther.1091.2013]. . Publication link: 90189f9b-436e-4bfd-813b-c3518a037de7
Kadirvel, M., Fairclough, M., Cawthorne, C., Rowling, E. J., Babur, M., McMahon, A., ... Brown, G. (2014).Detection of apoptosis by PET/CT with the diethyl ester of [ 18F]ML-10 and fluorescence imaging with a dansyl analogue. Bioorganic and Medicinal Chemistry, 22(1), 341-349. DOI:10.1016/j.bmc.2013.11.019. Publication link: ed2075af-ef05-4a97-b815-d1ecb6231ce6 | PubMed:24290974
Wouters, A., Pauwels, B., Burrows, N., Baay, M., Deschoolmeester, V., Vu, T. N., ... Lardon, F. (2014).The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein. BMC Cancer, 14(1), [594]. DOI:10.1186/1471-2407-14-594. Publication link: d2fccfa0-e2e5-489b-ab8f-0d7448d94574
Williams, K. J., Armitage, E. G., & Kotze, H. L. (2014).Correlation-based network analysis of cancer metabolism- A new systems biology approach in metabolomics. In Springerbriefs in systems biology. London: Published by Springer New York Heidelberg Dordrecht. . Publication link: e0390cb2-607a-403b-a423-5df4f48eb479
Williams, K. J., McCrudden, C. M., Curtin, E. N. (Ed.), & Sharma, R. (Ed.) (2014).The vasoactivity of PARP inhibitors. In In PARP Inhibitors for Cancer Therapy. Published by Springer, under the series Cancer Drug Discovery and Development, managed by Series Editor, Dr. Beverly Teicher (Chief, Molecular Pharmacology Branch, National Cancer Institute). . Publication link: d2ef5510-48f3-460b-948e-f21daa9342f1
Burrows, N., Telfer, B., Brabant, G., & Williams, K. J. (2013).Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity. Radiotherapy and Oncology, 108(3), 548-553. DOI:10.1016/j.radonc.2013.06.027. Publication link: 91599da9-23b4-4df2-bfeb-3542eada5ec3
Cawthorne, C., Burrows, N., Gieling, R. G., Morrow, C. J., Forster, D., Gregory, J., ... Williams, K. J. (2013).[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-Kinase inhibition with the novel agent GDC-0941. Molecular Cancer Therapeutics, 12(5), 819-828. DOI:10.1158/1535-7163.MCT-12-0905. Publication link: 37c6e874-1239-4016-afdf-05b94cc06128
Kotze, H. L., Armitage, E. G., Fletcher, J. S., Henderson, A., Williams, K. J., Lockyer, N. P., & Vickerman, J. C. (2013).ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems. Surface and Interface Analysis, 45(1), 277-281. DOI:10.1002/sia.5055. Publication link: 161b64df-6cea-4e12-8e71-977ea7d9448a
Simpson, K. L., Cawthorne, C., Zhou, C., Hodgkinson, C. L., Walker, M. J., Trapani, F., ... Macfalane, M. (2013).A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death and Disease, 4(5), e613. [e613]. DOI:10.1038/cddis.2013.137. Publication link: e9c4a01a-88a7-4204-adaf-7b5b63b4e821 | PubMed:23640455
Stovold, R., Meredith, S. L., Bryant, J. L., Babur, M., Williams, K. J., Dean, E. J., ... White, A. (2013).Neuroendocrine and epithelial phenotypes in small-cell lung cancer: Implications for metastasis and survival in patients. British Journal of Cancer, 108(8), 1704-1711. DOI:10.1038/bjc.2013.112. Publication link: c8b0e3e3-ee89-450b-8ce1-979f2607d5f8 | PubMed:23519056
Ferreras, C., Rushton, G., Cole, C. L., Babur, M., Telfer, B. A., van, K. T. H., ... Avizienyte, E. (2012).Endothelial Heparan Sulfate 6-O-sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to FGF2 and VEGF. J Biol Chem, 287(43), 36132-46. . Publication link: a50ac3c2-3daa-43ed-a73b-eba1cb879ce1
Gieling, R. G., Babur, M., Mamnani, L., Burrows, N., Telfer, B. A., Carta, F., ... Williams, K. J. (2012).Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. Journal of Medicinal Chemistry, 55(11), 5591-5600. DOI:10.1021/jm300529u. Publication link: 118b91e4-02fa-472b-bd1b-a109f83a2163 | PubMed:22621623
Ali, M., Kamjoo, M., Thomas, H. D., Kyle, S., Pavlovska, I., Babur, M., ... Williams, K. J. (2011).The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice. Molecular Cancer Therapeutics, 10(12), 2320-2329. DOI:10.1158/1535-7163.MCT-11-0356. Publication link: 5208a3c4-fc95-4d8d-9fad-1f920c9ba350 | PubMed:21926192
Burrows, N., Babur, M., Resch, J., Ridsdale, S., Mejin, M., Rowling, E. J., ... Williams, K. J. (2011).GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways. Journal of Clinical Endocrinology and Metabolism, 96(12), E1934-E1943. DOI:10.1210/jc.2011-1426. Publication link: 0850f86c-14bb-41ce-a793-5636d1539288 | PubMed:21994956
Golinska, M., Troy, H., Chung, Y. L., McSheehy, P. M., Mayr, M., Yin, X., ... Griffiths, J. R. (2011).Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas. BMC Cancer, 11, [198]. DOI:10.1186/1471-2407-11-198. Publication link: e11175f2-f5f3-4bb5-b875-f8dc99d1d448
Burrows, N., Resch, J., Cowen, R. L., Von Wasielewski, R., Hoang-Vu, C., West, C. M., ... Brabant, G. (2010).Expression of hypoxia-inducible factor 1α in thyroid carcinomas. Endocrine-Related Cancer, 17(1), 61-72. DOI:10.1677/ERC-08-0251. Publication link: cbd270c5-2b83-4308-b51c-ac064c45584a | PubMed:19808899
Lunt, S. J., Cawthorne, C., Ali, M., Telfer, B. A., Babur, M., Smigova, A., ... Williams, K. J. (2010).The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy. British Journal of Cancer, 103(2), 201-208. DOI:10.1038/sj.bjc.6605753. Publication link: f865f5eb-68ac-4b4c-9939-a114c64af83a | PubMed:20588272
Sommer, P., Cowen, R. L., Berry, A., Cookson, A., Telfer, B. A., Williams, K. J., ... Ray, D. W. (2010).Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth. Endocrine-Related Cancer, 17(1), 203-213. DOI:10.1677/ERC-09-0241. Publication link: 13408caf-f50a-4203-9141-581f50c0ede1 | PubMed:20015838
Ali, M., Telfer, B. A., McCrudden, C., O'Rourke, M., Thomas, H. D., Kamjoo, M., ... Williams, K. J. (2009).Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: A contributory factor to chemopotentiation in vivo?. Clinical Cancer Research, 15(19), 6106-6112. DOI:10.1158/1078-0432.CCR-09-0398. Publication link: df29a520-ae82-4b5b-b890-92494e41c669 | PubMed:19789326
Shannon, A. M., Telfer, B. A., Smith, P. D., Babur, M., Logie, A., Wilkinson, R. W., ... Wedge, S. R. (2009).The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts. Clinical Cancer Research, 15(21), 6619-6629. DOI:10.1158/1078-0432.CCR-08-2958. Publication link: c2f2aff2-d899-4389-9cd9-f5f5a1929648 | PubMed:19843666
Williams, K. J., Albertella, M. R., Fitzpatrick, B., Loadman, P. M., Shnyder, S. D., Chinje, E. C., ... Stratford, I. J. (2009).In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. Molecular Cancer Therapeutics, 8(12), 3266-3275. DOI:10.1158/1535-7163.MCT-09-0396. Publication link: 2b31ae8e-3480-436e-9f97-325f46bc8c2b | PubMed:19996276


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Election 2008
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Oliver Spryn
After learning 26 programming languages and frameworks, my software engineering career has gone full stack and beyond. I've applied these skills to make key areas of companies' workflow up to 90% more productive by developing software for the web, desktop, and GPUs.
- Pittsburgh, PA
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- Last seen Nov 16 '14 at 0:09
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The Greenfield Public Library will be closed Feb. 3, Super Bowl Sunday, a day when it is nearly deserted every year.
The Library Board approved the closure in November as part of its 2013 calendar approval.
As a side benefit, being closed on Super Bowl Sunday will enable the staff to enjoy Super Bowl parties and get-togethers, said Sheila O'Brien, director of the library, at 5310 W. Layton Ave.
The library's automated exterior book drop/check-in services and the web page will continue to be available.
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Categories: Flyers Photo Galleries Photos
Flyers vs. Penguins – December 14, 2010
Latest Galleries
Girl Power: Famous Women Say 'I'm With Her'As Hillary Clinton became the first female Democratic Presidential Nominee, famous women took to the Wells Fargo Stage to voice their support.
Bernie Supporters Rally During DNCThe Democratic National Convention is in town and with it comes hundreds of protesters showing their support for Bernie Sanders.
2016 Democratic National Convention
Sneak Peak Of DNC PoliticalFestThe event officially kicks off tomorrow.
A Look Back On Garry Marshall With The Actors He DirectedGarry Marshall passed away on July 19 at age 81. He directed numerous sitcoms and movies including "Happy Days" and "The Princess Diaries."
30 Years Of Joe ConklinJoe Conklin began his radio career in 1986.
#CBSPhillySTYLE Best Of Style
Historic Home At Bartram's Garden Gets A RenovationA historic home and garden inside Bartram's Garden reopens after being renovated.