text:
|Publication number
|Publication type
|Application number
|Publication date
|Oct 20, 1992
|Filing date
|Aug 26, 1988
|Priority date
|Aug 26, 1988
|Fee status
|Publication number
|Ulf R. Rapp
|Original Assignee
|United States Of America
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (2), Non-Patent Citations (12), Referenced by (27), Classifications (9), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates generally to cancer therapy. More particularly, the present invention relates to an anti-tumor vaccine utilizing oncoproteins as immunogen, either alone or in combination with other oncoproteins or potentiating agents.
Oncogenes are one of the several cancer or tumor causing factors. Oncogenes direct the synthesis of oncoproteins which differ from their normal counterparts in either structure and/or quantity per cell. Through certain mechanisms, which are not yet fully understood, oncoproteins may convert the normal cells into cancerous entities.
Immunotherapy utilizing monoclonal antibodies directed against tumor marker antigens, which are normal cell products, has been attempted as a modality in the treatment of cancer. However, this procedure has certain limitations or disadvantages:
(a) It introduces foreign protein (monoclonal antibodies) into the patient;
(b) Tumor-specific structure of antigens is usually undetermined; and
(c) Functional significance of the antigen for the cell is often unknown.
In contrast, oncoproteins are known to be responsible for the continual growth of the tumor cells. Furthermore, oncoproteins are often immunogenic in their natural host and their presence on tumor cells renders the antigen presenting cells susceptible to immune surveillance. Despite such knowledge, however, the efficacy and potency of oncoproteins as immunogenic agents for the treatment of cancer have not yet been fully determined.
It is, therefore, an object of the present invention to provide a vaccine employing oncoproteins as immunogen.
It is a further object of the present invention to provide a method of treating host derived cancer by inducing anti-oncoprotein antibodies in a host susceptible to or suffering from cancer.
It is another object of the present invention to provide a method of inhibiting carcinogen induced cancer.
It is an additional object of the present invention to provide an animal model for testing anti-tumor agents, vaccines and the like.
Other objects and advantages will become evident from the following detailed description of the invention.
These and other objects, features and many of the attendant advantages of the invention will be better understood upon a reading of the following detailed description when considered in connection with the accompanying drawings wherein:
FIG. 1 (A) and (B) shows the mortality curves of NFS�AKR F1 mice treated with ENU+BHT ( ) and those treated with ENU+BHT and vaccinated weekly with purified oncoprotein ( ). FIG. 1 (A) shows ENU versus ENU+BHT, where means 2A-ENU+Oil and means 2B,6B-ENU+BHT. FIG. 1(B) shows ENU+BHT versus ENU+RAF+BHT, where means 2B,6B-ENU+BHT and means ENU+RAF+BUT.
FIG. 2 (A) and (B) show the schematic construction of raf (A) and myc (B) carrying plasmids used for in vivo virus recombinations.
The above and various other objects and advantages of the present invention are achieved by a vaccine, comprising an immunogenic amount of isolated, substantially pure oncoprotein either alone or in combination with other oncoprotein(s) or potentiating factors. A method of treating cancer comprises inducing sufficient amount of anti-oncoprotein immune response to neutralize cancer causing oncoprotein in a host susceptible to or suffering from cancer. Of course, the oncoprotein can be utilized either in whole or in part and in combination with a plurality of other oncoproteins. An animal mode as described herein can be used to test the anti-cancer agents.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described. All publications mentioned hereunder are incorporated herein by reference. Unless mentioned otherwise, the techniques employed herein are standard methodologies well known to one of ordinary skill in the art. The term "substantially pure" as used herein means a product which is as pure as can be obtained by employing standard purification methodology well known to one of ordinary skill in the art.
The term "other potentiating factor or agent" as used herein means other oncoproteins or parts thereof and a general immune system stimulant such as Freund's adjuvant and the like.
In order to test the efficacy of the anti-tumor vaccine of the present invention, first a model system was developed. The system comprises an animal model for generating lung carcinoma which is the most prevalent cancer in the Western world. NFS mice are mated with AKR males and the pregnant mice are transplacentally injected at day 16 of gestation with ethylnitrosourea (ENU) at a dosage of 0.5 mmole/kg body weight of the mother. Then tumor promotion in weanling F1 is begun with weekly injections of butylated hydroxytoluene (BHT, 2 mg/10 g body weight). The offspring rapidly develop tumors starting at about 5 weeks of age. Two types of tumors result: lung adenocarcinoma (80%-100%) and T-cell lymphomas (60%-70%). It was found that the expression of c-raf-1 RNA and protein was very high in both types of tumor cells relative to the control tissue. Furthermore, live cell fluoroscence indicated surface expression of the predominantly cytoplasmic raf protein in tumor cells (data not shown). It was for this reason that raf oncoprotein was selected to determine whether induction of an immune response to raf oncoprotein in these mice would affect tumor development.
Accordingly, raf oncoprotein was produced in Escherichia coli with the aid of an expression plasmid following standard techniques well known in the art. The oncoprotein was then isolated from refractile bodies and purified by standard procedures such as high pressure liquid chromatography employing routine methodology. The isolated, substantially pure raf oncoprotein thus obtained was then used to vaccinate the carcinogen, tumor bearing F1 mice on a weekly regimen. The raf protein was injected into the animals intraperitoneally in Freund's adjuvant at a dose of 3 micrograms per week.
FIG. 1 shows the mortality curves of NFS�AKR F1 mice treated with ENU+BHT (◯) and of those treated with ENU+BHT and vaccinated weekly with purified raf protein ( ). The results clearly demonstrate the marked protective effect on tumor latency and development in the vaccinated mice. Both the initial and the mean time for tumorigenesis doubled with vaccinations at 2, 3 and 4 weeks of age. Statistical analysis demonstrated the significance of the achieved attenuation at a confidence limited of greater than 99.5% for a 2-tailed Cox test.
To further establish the efficacy of raf vaccination on tumor initiation and development, another strategy was followed. A eukaryotic expression vector, vaccinia virus, was employed as a vehicle for constitutive expression of the oncoprotein as opposed to the externally introduced, purified oncoprotein which may remain present and intact in the animal only for a relatively short period of time and may even become partially denatured or degraded during isolation. Since a second raf family oncogene A-raf occurs in an activated form in the carcinogen induced T-cell lymphomas generated in the tumor induction model described herein, A-raf was included in the vaccinia virus constructions. In addition to the preparation of the raf containing vaccinia recombinant, a myc containing vaccinia recombinant was also constructed (FIG. 2B). The reasoning behind myc carrying viruses is that since myc is a nuclear oncogene while raf is primarily cytoplasmic, a combination of such nuclear and cytoplasmic oncogenes may produce a synergistic effect in lung tumor development. Moreover, myc family genes are commonly found to be over expressed in lung tumors. Thus a vaccination with both oncoproteins, either sequentially or simultaneously may provide a more efficient and effective treatment regimen.
The construction of raf and myc vaccinia recombination plasmids for use in vivo is shown schematically in FIGS. 2(A) and (B).
NFS females are mated with AKR males. Animals are paired in different groups, one control and three experimental. For group 1, the control group, no treatment is given to either the parents or offspring. The other three groups each receive the following treatment. On day 16 of gestation (counting plug dates as day 1) pregnant females are given a transplacental injection of ethylnitrosourea (ENU) (dissolved in citrate buffer), at a concentration of about 0.1 ml of a 50 mM solution per 10 g body weight. Offsprings then receive weekly injections of butylated hydroxytoluene (BHT) (dissolved in corn oil) at a concentration of 0.1 ml of a 20 mg/ml solution per 10 g body weight, beginning at five weeks of age. Group 2 then receives no further treatment. Group three litters are exposed to a raf expressing vaccinia virus at three weeks of age. Group four litters are exposed to a myc expressing vaccinia virus at three weeks of age. Exposure to virus is via a tail-rub, wherein the tail is rubbed with a slightly abrasive material and virus spotted onto the area. Approximately 10 litters per group are used. Inoculation with recombinant vaccinia virus can be similarly utilized in other hosts. The results clearly indicate the efficacy of the treatment described herein.
It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application and scope of the appended claims.
|Cited Patent
|Filing date
|Publication date
|Jun 13, 1985
|Oct 20, 1987
|Elena Avram
|Treatment of symptoms of neoplastic diseases with nucleoproteins
|Sep 30, 1981
|Jan 19, 1988
|Mccollester Duncan L
|Vaccine and method for immunotherapy of neoplastic disease
|Chang et al., Relationship Between T Antigen and Tumor Specific Transplantation Antigen in Simian Virus 40 Transformed Cells, Journal of Virology, vol. 29, No. 1, pp. 69 74, 1979.
|Chang et al., Relationship Between T-Antigen and Tumor-Specific Transplantation Antigen in Simian Virus 40-Transformed Cells, Journal of Virology, vol. 29, No. 1, pp. 69-74, 1979.
|George E. Mark and Ulf R. Rapp, "Primary Structure of V-Raf: Relatedness to the SRC Family of Oncogenes", Science (1984) 224:285-289.
|George E. Mark and Ulf R. Rapp, Primary Structure of V Raf: Relatedness to the SRC Family of Oncogenes , Science (1984) 224:285 289.
|Hanahan, Heritable Formation of Pancreatic B Cell Tumours in Transgenic Mice Expressing Recombinant Insulin/Simian Virus 40 Oncogenes Nature, vol. 315, pp. 115 122, issue of May 9, 1985.
|Hanahan, Heritable Formation of Pancreatic B-Cell Tumours in Transgenic Mice Expressing Recombinant Insulin/Simian Virus 40 Oncogenes Nature, vol. 315, pp. 115-122, issue of May 9, 1985.
|P. Sutrave et al., "Nucleotide Sequence of Avian Retroviral Oncogene V-Mil: Homologue of Murine Retroviral Oncogene V-Raf", Nature (1984) 309:85-88.
|P. Sutrave et al., Nucleotide Sequence of Avian Retroviral Oncogene V Mil: Homologue of Murine Retroviral Oncogene V Raf , Nature (1984) 309:85 88.
|Tevethia et al., "Biology of Simian Virus 40 (SU40) Transplantation Antigen (TrAg)", Virol. 107: 13-23 (1980).
|Tevethia et al., Biology of Simian Virus 40 (SU40) Transplantation Antigen (TrAg) , Virol. 107: 13 23 (1980).
|Watt et al., "Expression and Characterization of the Human C-Myc DNA-Biding Protein", Mol. Cell. Biol. 5: 448-456 (1985).
|Watt et al., Expression and Characterization of the Human C Myc DNA Biding Protein , Mol. Cell. Biol. 5: 448 456 (1985).
|Citing Patent
|Filing date
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|Jun 2, 1995
|Jun 16, 1998
|The General Hospital Corporation
|Inhibiting protein interactions
|Nov 14, 1997
|Oct 9, 2001
|Cornell Research Foundation, Inc.
|Activated ras interaction assay
|Jun 7, 1995
|Mar 2, 2004
|Therion Biologics Corporation
|Recombinant pox virus for immunization against tumor-associated antigens
|Jan 17, 2001
|Nov 2, 2004
|Baofa Yu
|Combinations and methods for treating neoplasms
|May 15, 2001
|Feb 9, 2010
|Samuel Bogoch
|Methods and compositions for stimulating the immune system
|Apr 19, 2011
|Baofa Yu
|Combinations and methods for treating neoplasms
|Apr 22, 2010
|Mar 27, 2012
|Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh)
|Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells
|Sep 16, 2003
|Jun 26, 2012
|Helmholtz Zentrum M�nchen Deutsches Forschungszentrum F�r Gesundheit Und Umwelt (Gmbh)
|Semi-allogenic anti-tumour vaccine with HLA haplo-identical antigen-presenting cells
|Sep 7, 2007
|Aug 6, 2013
|Baofa Yu
|Targeting cancer therapy combination
|Nov 24, 2009
|Apr 15, 2014
|Helmholtz Zentrum M�nchen Deutsches Forschungszentrum F�r Gesundheit Und Umwelt Gmbh
|High affinity T cell receptor and use thereof
|Aug 5, 2013
|Apr 7, 2015
|Baofa Yu
|Compositions and methods for targeting of treating neoplasms
|Feb 15, 2011
|Jan 19, 2016
|Helmholtz Zentrum M�nchen Deutsches Forschungszentrum f�r Gesundlheit und Umwelt (GmbH)
|Semi-allogenic anti-tumour vaccine with HLA haplo-identical antigen-presenting cells
|May 15, 2001
|Apr 18, 2002
|Samuel Bogoch
|Methods and compositions for stimulating the immune system
|Dec 12, 2003
|Jul 1, 2004
|Levine Arnold J.
|P53 vaccine
|Sep 16, 2003
|Aug 11, 2005
|Dolores Schendel
|Semi-allogenic anti-tumour vaccine with HLA haplo-identical antigen-presenting cells
|Sep 2, 2005
|Feb 23, 2006
|The Scripps Research Institute
|Methods and compositions useful for modulation of angiogenesis using protein kinase Raf and Ras
|Feb 13, 2003
|May 18, 2006
|Rapp Ulf R
|Microorganisms as carriers of nucleotide sequences coding for cell antigens used for the treatment of tumors
|Sep 7, 2007
|Apr 29, 2010
|Baofa Yu
|Composition and method for treating tumor
|Apr 22, 2010
|Aug 12, 2010
|Elfriede Noessner
|Attack of tumor cells with missing, low or aberrant mhc expression by combining non mhc-restricted t-cells/nk-cells and mhc-restricted cells
|Nov 30, 2010
|Mar 7, 2013
|Agency For Science, Technology And Research
|Treatment and prevention of cancers associated with intracellular oncoproteins by antibody therapy or vaccination
|Nov 30, 2010
|Oct 24, 2012
|Treatment and prevention of cancers associated with intracellular oncoproteins by antibody therapy or vaccination
|Nov 28, 1997
|Jun 17, 1999
|Ulf R Prof Dr Med Rapp
|Transgenes nicht-menschliches S�ugetier mit einer onkogenen Mutante des Raf-1-Gens
|Nov 28, 1997
|Nov 25, 1999
|Ulf R Rapp
|Transgenes nicht-menschliches S�ugetier mit einer onkogenen Mutante des Raf-1-Gens
|Dec 22, 2006
|Aug 1, 2012
|Amgen Inc.
|Nintrogen-containing bicyclic heteroaryl compounds for the treatment of RAF protein kinase-mediated diseases
|Mar 16, 1994
|Sep 29, 1994
|Samuel Bogoch
|Recognin vaccines
|Feb 13, 2003
|Sep 4, 2003
|MedInnova Gesellschaft f�r medizinische Innovationen aus akademischer Forschung mbH
|Microorganisms as carriers of nucleotide sequences coding for cell antigens used for the treatment of tumors
|Feb 13, 2003
|Feb 12, 2004
|Medinnova Ges Med Innovationen
|Microorganisms as carriers of nucleotide sequences coding for cell antigens used for the treatment of tumors
|U.S. Classification
|424/277.1, 514/19.3
|International Classification
|Cooperative Classification
|European Classification
|Oct 4, 1988
Owner name: UNITED STATES OF AMERICA, THE, AS REPRESENTED BY T
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:RAPP, ULF R.;REEL/FRAME:004958/0468
Effective date: 19880826
|May 20, 1996
|Fee payment
Year of fee payment: 4
|May 20, 1996
|Surcharge for late payment
|May 28, 1996
|Maintenance fee reminder mailed
|Apr 19, 2000
|Fee payment
Year of fee payment: 8
|Apr 20, 2004
|Fee payment
Year of fee payment: 12


text:
We booked a King Suite room & a Double bed w/ DC view room. The agent guarantee us that the rooms were next to each other & on a higher floor. When we reached, we found out the rooms were in two separate towers (South & North). My sister ended up being upgraded (for free) to a suite. She ended up losing the DC skyline view. I was told all the suites are recently renovated and are in the South tower. The room was was very nice/modern but not thoroughly cleaned. Soda & two water bottles were found in the fridge. A couple of napkins were found on the floor near the sofa, while plugging in our phone chargers. Bed was comfortable. Two flatscreen tvs; one w/ game access. Being we had a suite, it would have been nice if the room had sheets and/or blankets available to use for the sofa bed. For whatever reasons, we could not get the temperature in the room right. It didn't allow you to raise it no more than 75 degrees (Fahrenheit) so we were cold the entire night. Self-parking is $26/day & Wifi is $11.95/day. The hotel "store" is expensive, paid $20 for 4 bottles of soda (20 FL OZ); normally $1.75 each in a grocery store. The location is great, less than 10 minute drive to DC National Mall.
- Official Description (provided by the hotel):
- Full service hotel minutes from Ronald Reagan National Airport and located across the Potomac from Washington D.C. just two blocks from the Pentagon and Fashion Centre Shopping Mall. Houses the areas only revolving rooftop restaurant and lounge featuring views of the DC skyline. Amenities include luxurious guest rooms and suites with high speed internet access, fitness center, indoor heated pool, lobby bar, cafe, and fine dining restaurant. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Hotels.com, Hilton Hotels, Expedia, Booking.com, Priceline, Hotwire, getaroom.com, Travelocity, Odigeo and Cancelon so you can book your DoubleTree by Hilton - Washington DC - Crystal City reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Doubletree By Hilton - Washington Dc - Crystal City Hotel Arlington
- Doubletree Hotel Arlington
- Doubletree Crystal City National Airport
- Doubletree Hotel Crystal City

subset: commoncrawl


text:
Meet the women of Iditarod
Alaska is a land of extremes. A quick trip into town can take six hours, while treacherous, 1,000-mile races that span 10 sleepless nights in sub-arctic temperatures are considered fun. It's also been called the place where "men are men and women win the Iditarod."
The Iditarod Trail Sled Dog Race, a 1,049-mile race across Alaska from Anchorage to Nome, got its start in 1973 as a commemorative event celebrating the 1925 diphtheria serum run that saved the inhabitants of Nome from a potentially devastating outbreak. While the mushers' gear and training have become more sophisticated since the early years, the race's tradition remains the same.
Completing the race requires many things, including a sturdy -- perhaps even a little crazy -- mind; a team of eager, well-cared-for sled dogs; attention to detail when it comes to preparation; and a steely resolve to fearlessly face the challenges the trail can present.
This year's epic adventure starts Saturday, and 16 women have accepted the call to run "The Last Great Race on Earth." Among them is a 10-time veteran who could win it all, a former fashion model, a pair of identical twins with a ton of potential and a former zookeeper whose love for her dogs always trumps her placement amid the field.
The veteran: Aliy Zirkle
The 42-year-old New Hampshire native is one of the top female mushers. Lured to the frozen American outback by a love of animals and adventure, Zirkle said she "found home" when she arrived in Bettles, Alaska (population: 35), for an internship with the U.S. Fish & Wildlife Service after graduating from the University of Pennsylvania with a degree in biology and anthropology.
"I turned up in the tiniest town in Alaska, 50 miles north of the Arctic Circle, in May 1992 with two boxes stuffed with everything I owned," she said. "I adopted a dog right away, and that showed I was here to stay."
After four years in rural Alaska, Zirkle needed a change of scenery and moved to Two Rivers, Alaska, a town near Fairbanks that boasts more than 10 times the number of residents of Bettles -- 482 people. There, she was also faced with the reality that she needed to start making more money.
"In Alaska, you either become a fisherman or start building or bartending, so I chose construction," she said.
She met her husband, Allen Moore, on one of her construction jobs. "The best-looking guy on the site," Zirkle said.
Zirkle and Moore still do construction on the side, but their primary business is mushing and running SP Kennel. Their hard work has led to two 11th-place Iditarod finishes for Zirkle, who collected a $20,100 prize in 2011. This year, she's eyeing the podium.
"I would like to win, to be honest," Zirkle said. "Anything can happen in 1,000 miles, but my team is definitely of the caliber of winning. For [the next] nine or 10 days, we're going for it."
Fashionable finisher: Zoya DeNure
Slim and bright-eyed with a smattering of freckles across her nose and cheeks, DeNure radiates fresh-faced beauty. Raised in Black River Falls, Wis., DeNure has girl-next-door appeal that caught the eye of a model scout at a shopping mall in St. Paul, Minn. DeNure, who was 13 at the time, spent the next nine years on a journey through the fashion houses and runways of Europe.
As exciting as it was, over time the novelty of her dream-come-true modeling career fizzled.
"I was tired of the grind and the superficiality," DeNure said. "I was burned out. So I bought a dog and said, 'I'm going to stay in one place for a year and have a normal life.'"
It was around the same time DeNure, who had volunteered at an animal shelter as a kid, connected with a woman running sled dogs in Wisconsin.
"I got into it and I read about Alaska and the Iditarod and thought, 'Wow! Who could do this thing?'" DeNure said. "And from there it turned into a dream."
She moved to Alaska and started handling dogs for DeeDee Jonrowe and Susan Butcher, two legendary Iditarod racers. DeNure worked her way up to mushing.
DeNure, 34, lives in Gakona, Alaska, with her husband, musher John Schandelmeier, and 3-year-old daughter, Jona. They run Crazy Dog Kennel and Canine Rescue. Starting her third Iditarod this weekend, DeNure is hoping for a better result than 2011, when she had to scratch early in the race. One of her dogs developed a mysterious illness and she refused to continue without him. The dog ended up recovering but will spend this year's Iditarod in his new home. "I could never race him again, so I adopted him out to a friend who lives in Germany. It's a good home for him," she said.
Despite the happiness in her mushing life, DeNure said sometimes her former career creeps back in, but she's approaching opportunities that arise practically. "I'm getting casting calls for some commercials. That might pay for some dog food, so I may do it," she said.
This week, however, she's looking a few feet beyond her lead dog: "I think we can have a top-20 finish, maybe even better than that. They're capable of winning, but I don't have that experience yet."
Double take: Kristy and Anna Berington
The Iditarod's first set of twins, 28-year-old Anna and Kristy Berington, are from Port Wing, Wis., and joined the Army National Guard after high school graduation. They live in Kasilof, Alaska, a place that, like the sport of mushing, captured their imagination and feeds their desire for adventure.
"Mushing is as close to a magic carpet ride as you can get," Kristy said. "You get to go places only dog teams can reach. You get to run over mountains and frozen rivers. It's quiet and peaceful, but the endorphins are firing when you're screaming down a mountain."
Kristy will run her third Iditarod in 2012, after a strong debut in 2010 and a top-30 finish in 2011. She works with Paul Gebhardt and his 80-dog Morning View Kennel while also helping Anna, who will race in her first Iditarod this week. Anna works with 1984 Iditarod champion Dean Osmar, caring for and training his dogs.
Though the twins are athletic and swim, run and enjoy other sports, Kristy and Anna said they don't specifically train for the ultra-endurance event. "It's the life that you live with the dogs. You get lots of exercise doing chores, lifting 60-pound dogs. It's definitely a good workout just to run them," Kristy said.
Though still in the early phases of their careers, the Beringtons show promise and could become the next generation of top female mushers.
Compassionate competitor: Colleen Robertia
Rounding out the short list of women who could contend at the Iditarod is zookeeper-turned-schoolteacher Colleen Robertia.
Robertia, who is running in her second Iditarod, has also hiked the entire 2,168-mile Appalachian Trail. She got her start as a dog handler for Osmar and now runs her own kennel, Rogues Gallery Kennel.
Robertia, 35, is from North Attleboro, Mass., and graduated from St. Lawrence University in 1998 with a degree in environmental biology. She worked with the Wildlife Conservation Society in Georgia and later with a zoo in Jacksonville, Fla. Four time zones and a completely different climate away is her home of Kasilof, a "mushing mecca." Not long after Robertia moved to Alaska in 2003, she started running dogs.
Unlike some other mushers hitting the trail this weekend, Robertia does not have a robust list of sponsors and funds most of her 40-dog kennel. Money's tight, and Robertia said she will often scoop up the protective booties other mushers cast off along the trail to mend and reuse.
Just as she recycles gear, Robertia also refuses to dump dogs that are no longer able to perform in a racing capacity, an expensive proposition but one that could turn into a selling point for some potential sponsors.
Robertia's primary supporter is Kassik's Brewery in Kenai, Alaska. The company loved the story of Robertia's spunky lead dog, Penny -- who recovered from a car accident and fused ankle to complete the Iditarod -- so much that they brewed a porter and put Penny's picture on the label. Proceeds from the sale of "Penny Porter" and associated merchandise help Robertia feed the rest of the team.
Heading into the weekend, Robertia said she's "incredibly excited and anxious. Racing brings all your emotions to the surface. I've been training for a year, but I think it'll be a challenge to break the top 30. It's a competitive field this year, but what keeps me in the sport is my love of my dogs and this desire to show that you can do this competitively and lovingly and humanely."
Elaine K. Howley is an open-water swimmer and freelance writer in Boston.


text:
The Moline Community Foundation will accept grant applications until mid-April.
All materials are due to the Moline Foundation offices, Deere-Wiman House, 817 11th Ave., Moline, or postmarked by 4 p.m. April 15.
Any nonprofit, 501(c)(3) organization that serves residents of Moline and the surrounding region is welcome to apply. An application should consist of 11 copies of a written request stating the name and address of the organization, its mission, names and addresses of board members, income and expense statement, balance sheet and the specific purpose for which any money received would be used, including a project budget. The name, telephone number and email of a contact person also must be included.
For more information, contact director of donor and community relations Linda Martin at 309-764-4193.


text:
Game 23 Thread / Cubs @ Nationals (1 of 3)
Game Chat | Press Pass | BR Preview
|Ryan Dempster
|*Odalis Perez
|Reed Johnson
|#Felipe Lopez
|Ryan Theriot
|#Cristian Guzman
|Derrek Lee
|Ryan Zimmerman
|Aramis Ramirez
|*Nick Johnson
|*Kosuke Fukudome
|Lastings Milledge
|Mark DeRosa
|#Johnny Estrada
|Geovany Soto
|Wily Mo Peña
|Ronny Cedeno
|*Rob Mackowiak
|Ryan Dempster
|*Odalis Perez
WIth tonight's first-ever visit to Nationals Park, the Cubs will have played in three different cities in three different time zones, necessitating somewhere around 2,700 miles in air travel, all in a little over 72 hours. Gotta love those schedule gremlins.
Even with yesteday's loss to the Rockies, the first-place Cubs have won 8 of 10. After opening the season 3-0, the fifth-place Nationals, who needed 13 hits against the Mets on Thursday to raise their team average to .233, have lost 16 of 20.
The Cubs beat Washington in 6 of 7 games a year ago, winning 3 of 4 at RFK.
As for tonight's pitchers, the Cubs' Dempster labored through five innings and 94 pitches last Sunday against the Pirates, a game the Cubs won 13-6. Perez, the first of three lefty starters the Cubs will see in this series, hasn't hooked up with the Wrigleys since his days as a Dodger in 2004. He has also pitched well enough to win in four of his five starts, but hasn't won any.
Five runs of offensive support in 26 2/3 IP will do that to a guy.
If you liked this article, consider supporting us during TCR's April Pledge Drive.
Re: Dempster labored through five innings and 94 pitches
He wasn't laboring at all until the fifth inning when he suddenly lost his command as only Ryan Dempster can do. Took him 37 pitches to get out of the inning.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
For those not watching the game, Johnson just made a highlight reel catch. One of the best I've seen this year.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
That catch by Johnson was amazing. You have to see it to believe it.
However, I saw it and I still can't believe it...
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
well, that sucked. Theriot can't steal bases worth shit anymore. Howry is still struggling. We burned another long inning out of Marmol. And, as hard as it is to say, I would have much rather had Cedeno hit with the bases loaded. Using up Cedeno, Ward, Murton, Blanco, and Fontenot to get one RBI walk and one K seemed like a waste.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
I have to admit I was a bit suprised by all that. When the bases got loaded after the IBB and Cedeno up, I thought he'd go to Fontenot since Acta would certainly go to the lefty and burn Fontenot instead of Ward there...and then go Murton. That would have left Ward for the next AB instead of Fontenot. Unless Lou thought there was a chance that Acta would have left Ayala in there...but that seemed unlikely.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
Cubs seem to be finding ways to lose the last couple of games. Haven't been getting the big hit or making the big pitch/defensive play at the end of games. Oh well. It's a long season and there was bound to be some bounce back from their nice run of late. Neither loss was necessarily a poorly played game, but just a couple of wasted opportunities.
I will say, though, that it may be time to find a different answer on the bench than Little Lord Fontenot, at least for the time being. He's not really giving them what they need. He's not a good glove guy and he's drawn 1 walk so far in almost 40 PA's. He looks very unsettled at the plate and it really seems to be wearing on him. He strikes me as a good guy and I think he can be a good role player, but this team really can't wait for a bench guy to find himself. When Sori comes back, I'd let Murton hang around and send Fontenot down to find his groove.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
not getting the big hits the last couple games. still opportunities, but not the big, break-it-open hit. Guess that's why we have 5 runs in 2 games.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
How long will Lou stick with Fontenot on the team? He's been pretty useless -- huge K today with the bases loaded and one out in a tie game. Loved him when he was hitting .400 last year -- since then, not so much.
Re: Game 23 Thread / Cubs @ Nationals (1 of 3)
I agree about Fontenot. Enough. However, the vaunted Mark DeRosa has been terrible and a strike out king with bases loaded, or any key hitting situation - save for one time against the Mets so far. In fact, imo, if I never see him bat w/the bases loaded again it will be too soon.
Recent comments
Lester has given up one run or fewer in 11 starts this year. So I'd answer yes. Three of his last four starts were duds, yes. Not worried about him at all. Arrieta is concerning, to be sure. I look it at as, what he was doing was historic, so the regression was bound to happen. He showed in his start against the Mets that he's still capable, and I'd bet on him regaining his form.
marlins getting a.cashner and c.rea from SD
This is not an attack...But In what stat are the Cubs second from last in MLB, in hitting? I don't see this.
How odd the stats:
Cubs 1st in pitching in MLB
2nd to last in hitting.
In May they were 1st in both.
trevor clifton (high-A) could be interesting in a couple seasons...could even become a high/middle rotation guy. he's got a lot of pluses in his pitching except control.
eric leal's (high-A) progression through the minors should be worth watching even if only projects to be an mid/end-rotation starter.
we also gotta keep a long-distance eye on guys like jose paulino (ss-A) and preston morrison (A).
As Johnny Bach used to say when it was time for the MJ Bulls to crank up the defensive pressure: "Release the Dobermans!", and Jordan, Pippen, Rodman and Harper would just suffocate the other team.
I'd love to add Carl Jr. to that group - he's got the stuff.
Historically, the Moneyball guys have been great at identifying productive hitters. Not so much with pitchers.
Wow - Pierce Johnson with an ERA of 8.01 in 42IP!
What a stud prospect! Must be pitching with a pierced johnson.
Looks like Ryan Williams is the only legit prospect there. That is sad...
Well it would seem that's all they need now. "Stropy" can have his moments, but he's been more consistent post-asg.
Take THAT, Cardinals -- you beat Fernandez, we beat Sale.
I really like Lackey as a 6-inning pitcher.
Three amigos? Because the Dominican, the Venezuelan, and the Cuban?
Maybe the three-headed dragon?
Who says Contreras can't frame? Stone cold robbery of Eaton with that called third strike for the first out in the eighth
Three amigos time?
he should hit more of those. that would be an ideal outcome. /moneyballs
Russell with 19 RBI in July so far. Grand Slams help.
...and Familia with back-to-back blown saves. Blows a one-run lead vs. Rockies today, gets his 2nd consecutive loss.
I am OK with the Mets missing the playoffs and suffering crushing losses at home --- just want them to beat St. Louis.
He played with fire twice agains the Cubs -- unfortunately, the Cubs couldn't stop swinging.


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Show transcribed image text Draw schematic for a Bridge (full-wave) peak-rectifier that provides dc output voltage of-10V (negative 10V) with a plusminus 1V ripple. Be sure to mark the ground! Assume the load of 47 Ohm at the output. Calculate the transformer ratio, the capacitor value, the PIV for the diodes, and the average power delivered to the load resistor.


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Zinc Sulfate - takeing 220mg per day, would the large dose be because of bedsore?
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David Wolff and Cyndi Lauper had a relationship.
Cyndi has noted that her relationship with Dave was largely ruined by their differing views on where her career should go. "Once the business snuck into our relationship, it ruined it", she said in 2002`s Behind the Music. He wanted her to re...cord pop hits and stay with her current image. Cyndi was not happy with this, being more concerned with artistic efforts and making a statement. In 1988, while working on Lauper`s album, A Night To Remember (1989), they met in his New York office and agreed to end it. (it is implied by his comments that she was the one who officially decided they should no longer see each other).
The split was hard on Lauper; she was close to ending her career, and the album flopped with only one #1 hit, I Drove All Night. She took time off and went onto making movies (Off and Running) in 1991. She and co-star David Thornton fell in love and married later that year.


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Edmund Lee, managing editor of tech news website ReCode explains who is making money on Pokemon Go and what it could mean for the future of gaming and other industries. » Read More
It's been five years since the passage of Dodd-Frank. Is the average American better off? Former Rep. Barney Frank (D-Mass.) on whether the landmark financial reform-law is protecting Americans.
America's health care industry is being dragged into the 21st century when it comes to being connected. Why is it so tough for Doctors to go digital? Athenahealth Chairman & CEO Jonathan Bush discusses health care innovation and where we¿ll be in five years.
D'Addario & Company CEO Jim D'Addario comes from a long line of musical instrument string makers. What started as a craft in Italy in 1680 is now a multi-million dollar eight-generation family business based in New York. Kate Rogers reports on how keeping it all in the family is still in tune with success.
For some, money woes could point to other underlying problems. That's where financial therapists come in. Personal Finance Correspondent Sharon Epperson reports on how taking a deeper look into your financial well-being could boost your wealth and health.
Despite the consolidation of major U.S. airlines, there are still lots of choices for how to find and book flights. Kayak Co-Founder & CEO Steve Hafner discusses whether fewer airlines and more travel sites mean better bargains.
Tech and fashion don't always mix and no one wants to look like a robot. Accessories and apparel designer Rebecca Minkoff and her brother, Uri, discuss how they join retail with innovation for tech savvy consumers.
Uber has become a multibillion-dollar business by putting drivers on the road to becoming entrepreneurs. But if you think Ubers driver are largely Millenials looking to earn pocket change then guess again. Kate Rogers reports on how Baby Boomers are enjoying third-acts in the sharing economy.
Is going solar a bright idea? Personal Finance Correspondent Sharon Epperson explains whether spending money on solar means big savings, or big headaches.
The average pro baseball team is worth at least $1.2 billion. Still, the game isn't drawing younger fans. The Washington Post Senior Editor Marc Fisher and the Wharton School's Kenneth Shropshire discuss whether it's an aging audience, or something more ominous.
International business travel hit nearly $1.2 trillion in 2014. As corporations look to increase cross-border businesses, employers are concerned about workplace safety for expatriate staff. CNBC's Dina Gusovsky undergoes survival camp for business execs and shows how to survive a kidnapping.
With some 65 million freelancers and solo entrepreneurs in the workforce by 2020, the demand for office space and services outside the home is growing. Mission 50 Workspaces Pres. & Co-Founder Gregory Dell Aquilla and Grind Co-Founder Benjamin Dyett discuss the real estate needs of a co-working community.
If you're holding cash, finding the highest interest rates on FDIC-insured savings accounts can be a chore. Personal Finance Correspondent Sharon Epperson explains how to get the most out of your money.
Millions of Americans will hit the road for July 4th weekend, and they¿ll likely hit a pothole or two. Former Pennsylvania Governor Ed Rendell sounds off on how Washington can repair our broken transportation system.
Who's watching TV? According to "Television Is The New Television" author Michael Wolff, almost everyone. He reveals how the television industry one-upped the digital revolution to come out on top while other industries like print and music failed.
A startup wants to help theater-goers score last minute Broadway tickets for a steal. Today Tix CEO Merritt Baer and Chairman Brian Fenty explain how their app is changing the industry for the better.
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Can an app a day keep the doctor away? Reporter Bertha Coombs finds out from a group of doctors and patients who is using the Apple Watch to fight against diabetes.
The theme park business is on the upswing with more roller coasters debuting this year than at any time since 2008. About.com Theme Park Expert Arthur Levine reviews the ones not to miss and explains how you can afford to ride them all this summer.
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These two cotton industry organizations represent their members in the legal, legislative and regulatory affairs of their respective businesses.
These two cotton industry organizations represent their members in the legal, legislative and regulatory affairs of their respective businesses.
The membership of the Growers Association currently produces 100% of the total cotton produced in California. The total number of cotton growers is estimated to be approximately 750 statewide.more
Want to know the latest issues facing California cotton ginners and growers? From Air Quality to Water
Quality to Pesticides, the Cotton Chronicle covers the most pressing issues and our involvement for our members.
Welcome to the California Cotton Ginners and Growers Association's website. Here you can find out what we are up to with our latest news feed, learn more about specific industry issues, or learn more about us and what our organizations do for the California cotton industry.
The California Cotton Ginners and Growers Associations are voluntary agricultural trade associations that proudly represent 100% of all cotton ginners and growers in the state. Our associations represent our members on a variety of issues at both the state and federal level, including air quality, water quality, energy, environmental, labor, taxes, transportation and many others. Our focus is solely on California cotton, which gives us the opportunity to specifically represent the interest of the California cotton industry. With numerous success stories under our belt and many more on the horizon, the associations have gained a reputation for first class representation both locally and statewide.
News & Issues
The California Cotton Ginners and Growers Associations (CCGGA) participated in a meeting of agricultural organizations the California Department of Pesticide Read More…
The Environmental Protection Agency (EPA) has determined that the San Joaquin Valley nonattainment area "has attained the 1-hour ozone National Read More…
The dirt isn't moving just yet, but the real work on the Temperance Flat Dam and Reservoir is now underway. Read More…


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Looking for an intern to assist with writing website copy, social media posts and youtube optimizations. This is an intern to hire position. If the intern does well, they will be hired at the end of t…
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Barnegat High School's Gregory Moran, the top seed in the 195-pound bracket, was named the Most Outstanding Wrestler at the District 24 tournament at Pinebelt Arena in Toms River on Saturday.
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Ocean & River Cruises
Discover destinations around the world through our collection of best in class cruise lines- all of which we are top producers or hold elite status. Search from our sophisticated database of current cruise itineraries or browse through our exclusive offers for the top trending world cruises, river cruises, expedition cruises and beyond.
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May Day! The fight is near and everyone has their predictions but who do YOU think will take the belt as champ tonight? Take the poll! Mayweather vs. Maidana. Who's it going to be?
-DJ Dimepiece "The Mixin' Vixen"
Also On Power 107.5:
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DVI News and Events
April 13, 2016
What's the process behind vaccine registration and policies for use? Here we share an overview of the different considerations involved at the local, regional and global level. At a country-level, vaccine manufacturers are given a marketing authorization (also known as a license or registration) by a national regulatory authority (NRA), which permits commercialization of the registered product within the country. NRAs register vaccines based on an evaluation of the quality of the...
April 07, 2016
Dengue, also known as breakbone fever, is a painful and sometimes fatal viral disease transmitted by theAedes aegypti mosquito. Dengue fever typically impacts urban environments in tropical and subtropical regions. There is no specific medication or cure available for dengue. Without proper treatment of symptoms, fatality rates of the severe forms, such as hemorrhagic fever, can exceed 20 percent. Dengue prevention efforts to date have focused on vector control, through insecticide...
September 14, 2015
By Dagna Constenla, Gatien de Broucker, Jorge Martin del Campo and Alexandra Greenberg IVAC at Johns Hopkins University The successful introduction of a vaccine in affected countries depends heavily on issues such as supply constraints, potential demand, and the impact of policy decisions on future demand and supply. Strategic demand forecasts (SDFs) play a central role in enabling vaccine suppliers, donors, and country-level stakeholders to make informed decisions about vaccine supply,...
How to Fight a Mosquito that Costs over $2 Billion in the Americas -- Expert Conclusions from Meeting in Bogota
August 31, 2015
Earlier this year, DVI convened the Americas Dengue Prevention Board along with scientists, global health experts, mathematical modelers and representatives of dengue vaccine manufacturers to discuss updates in dengue vaccines and vaccine introduction. Held in Bogota at the Colombian National Institute of Health (Institituto Nacional de Salud – INS), the meeting was instrumental given the new available clinical trial data, particularly the results of the first Phase 3 trials ever...
Dengue in Sri Lanka: Burden, Challenges and Prevention Strategies -- An Exclusive Interview with Dr. Hasitha Tissera
May 20, 2015
Dr. Tissera received his bachelor's degree in medicine and surgery in 1995 and his residency training in the Provincial General Hospital in the remote mountainous region of Badulla. After being posted in to Ampara, the District capital city of the then war-torn eastern province in Sri Lanka, he learned about the basics in public health, in a new light -- hands on, under ongoing civil unrest and hostilities. Dr. Tissera joined the Central Epidemiology Unit subsequently, and in 2005...
March 04, 2015
In November of 2014, DVI held a two-day meeting to discuss the status of a dengue vaccine and exchange views on its licensure and introduction. Members of the Asia-Pacific Dengue Prevention Board (DPB), modelers of the impact of vaccination on dengue, public health specialists and dengue vaccine candidate representatives contributed to these important conversations. The meeting, held in Seoul, South Korea, consisted of four main activities. Participants reviewed the clinical development...
New DVI Report on Americas Dengue Prevention Board Meeting focused on Integrating Control Strategies
September 25, 2014
This year's Americas Dengue Prevention Board (DPB) convened in Mexico City from March 25–26. The meeting's objective was to assess the feasibility and benefits of integrating dengue vector-control strategies with an upcoming dengue vaccine. DVI compiled a summary of the discussions and recommendations from the Board in a new report you can access here. The meeting brought together vaccine and vector control experts, researchers, representatives of ministries of health...
September 15, 2014
Titled, "New chapter unfolding in the fight against dengue with an unwritten ending," the Dengue Vaccine Initiative's (DVI) editorial just published in the October issue of Transactions of the Royal Society of Tropical Medicine and Hygiene discusses the results of Sanofi's dengue vaccine candidate Phase 3 trial in Asia. DVI experts explain that while these results show promising indications that a safe dengue vaccine is technically feasible, key questions remain...
September 05, 2014
The Prerelease On Wednesday, Sanofi Pasteur published a press release with preliminary results of the second arm of the Phase 3 trial of its candidate dengue vaccine. The trial was conducted in Brazil, Colombia, Honduras, Mexico, and Puerto Rico and involved 20,875 children and teenagers aged 9 to 16. The announcement follows a series of updates made through the year about a previous similar, though smaller in size, Phase 3 trial conducted in Indonesia, Malaysia, the Philippines,...
July 10, 2014
Please click here for the Dengue Vaccine Initiative (DVI) full statement. Today, July 10, Sanofi Pasteur published in The Lancet the results of the first of two Phase 3 clinical trials for its dengue vaccine candidate — a live attenuated chimeric tetravalent vaccine. The study is a randomized, observer-blind, placebo-controlled multicenter trial involving 10,275 children aged 2 to 14 years in Indonesia, Malaysia, the Philippines, Thailand and Vietnam. An Initial Examination of...


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...I have been programming with Visual Basic for many years (10+) in all versions. Currently I teach programming using Visual Studio. I also program in Visual Basic in Microsoft applications.
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Free personalized radio that
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Billy Williams
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Photos: Landscapes
Early Morning Fog
Taken in Bar arbor at first light. View Photo »
View From Wheeler Mountain
This is a view from Wheeler Mountain in Barton, Vermont. View Photo »
Fall Reflections
Fall reflections in a stream near Thetford, Vermont. View Photo »
Sunrise in Litchfield
Shot from my bedroom window looking east in January 2003. View Photo »
Grist Mill at Longfellow's Wayside Inn
Grist Mill at Longfellow's Wayside Inn in Sudbury, Massachusetts. View Photo »
Country Bridge
This is an old wooden bridge adorned with beautiful fall colors along a rural road in northwestern Maine. View Photo »
Cape Cod in Autumn
A ring of fiery leaves circles this harbor in Provincetown. View Photo »
Park Bench
View of a park bench in Great Island Common, New Castle, New Hampshire. View Photo »
View of Mt. Chocura
Summer view of Mt. Chocura from the shores of Lake Chocura, Tamworth, New Hampshire. View Photo »
Cabin on Lake
A peaceful setting. View Photo »
Kancamagus Hwy
Fall colors along the Kancamagus Highway from North Conway. View Photo »
October Beach
Empty Adirondacks watch Long Island Sound View Photo »
My Own Backyard Display
Taken in my backyard, which always seems to peak about 1-2 weeks behind the "natural" forest. View Photo »
Sunapee Harbor
Red boat in Sunapee Harbor. View Photo »
Canopy of Color
This was taken on a cool fall morning at Wells State Park in Massachusetts. View Photo »
Oranges Win
Taken on route 8 near Colebrook, Connecticut. View Photo »
The Valley Below
Photo taken from the sharp turn on Route 2, just east of North Adams, Massachusetts. View Photo »
Birches in Transition
Taken from Route 8 near the Connecticut-Massachusetts border. View Photo »
Crawford Notch
Taken from the Conway Scenic Railway in October 2003. View Photo »
Mt Washington Summit
Eighty mph winds - October 2003. View Photo »
North Conway Golf Course
Astonishing colors. View Photo »
Corn Field Past Prime
This is a local farm noted for its windmill. View Photo »
Fenced in cows
In the distacne are some cows on a farm near where I live. View Photo »
Beaver Pond in Autumn
Taken Oct.13, 2003 View Photo »
Field & Foliage
Taken Oct 13,2003. We spent a couple of hours roaming Canterbury and stumbled onto this view. It is not... View Photo »
Relaxing in Sugar Hill
Resting in the field with the foliage in the background View Photo »
A Mexican sunflower in Vermont. View Photo »


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Daily VideoOctober 25, 2013
Parents Go to School to Help Students Succeed
One Saturday a month, moms, dads, grandparents and guardians gather in a Los Angeles classroom to learn about learning. The teacher stresses the importance of study habits, homework and high expectations for their children.
The classes are part of an experiment in some of the schools in America's second largest school district. Officials hope to see graduation improvements that can be scaled for the more than 690,000 students in the system.
The 17 schools managed by the nonprofit Partnership for Los Angeles are trying Parent College as a way to encourage families to aim for graduation from high school and then college.
"The success of your child depends on the strength of our triangle, you, the parent, your child and me," Martha Maitchoukow, a teacher at Parent College, tells the parents in her class. "I cannot do it by myself. You cannot do it by yourself. Your child cannot do it by himself or herself."
Studies show that kids with involved parents have better academic success and are more likely to graduate from high school and go on to college. This is particularly important in Watts, where the community faces many educational challenges and only roughly half of students will graduate from high school.
Ana Rojas, a mother who participates in Parent College, hopes her two children will buck this trend.
"I want to learn more every day. I want to use what I learn to help my kids at home, be like an additional teacher at home," she said. "Today, I learned I have to be more attentive so that they will go to university one day and distinguish themselves as good professionals."
The program is also helping parents who dropped out get a second chance at an education. Nadia Solis, another Parent College attendee, earned her high school degree after a conversation with her young daughter, Darlene.
"Her answer to me was, if you didn't finish high school, why are you telling me?" said Nadia. "I just gave her a simple — a simple answer of, well, I just couldn't. But the minute that I had Parent College the next week, it was my first question to my teacher: What can I do to get my GED?"
Warm up questions
- Why is it important to finish high school?
- Is it important to go to college? Why or why not? What are some of the risks and benefits associated with going to college?
- Who do you think has the greatest impact on how well you do in your own education and why?
Discussion questions
- Do you think that the Parent College program is going to make a difference in the lives of the parents? How about in the lives of their kids? Why or why not?
- What are some of the reasons that people don't finish high school or college? What solutions can you come up with to help others overcome those challenges?
- Imagine you are a parent, what three pieces of advice would you give your child about school?
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Trump picks Indiana Governor Mike Pence as running mate
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The inaugural STUDIO Conference – Storage Technology and Uses, Deployment Integration and Operations – is an energy storage event covering the advancement and integration of technology to support electric service. Produced in partnership with the Electric Power Research Institute (EPRI), STUDIO brings stakeholders from across the energy industry together for a unique meeting that explores the real-world technical experience of rapidly accelerating energy storage deployments.
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WE Build Webcast Series
Join GRID Alternatives for lively discussions with women working in every aspect of the solar industry, from construction to tech to sales and marketing. These quarterly webcasts are an opportunity to learn from successful solar women about the joys and challenges of their work in a rapidly growing and changing industry.
Solar Installed: The People and the Process enabling Market Acceptance and Installations
Regardless of your company's place in the value chain, codes and standards impact your solar business. This webinar is the third in a series that will help you understand the role codes & standards play in your delivery of solar goods and services. This webinar will cover how solar products ultimately get accepted in the marketplace, what tools and best practices are available for use and reference by the professionals engaged in that process, and how industry can work collaboratively with regulators to ensure smooth permitting and deployment.
Solar Power International
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None of this sermon material may be used at any time in any Bible School without the permission from Spirit Word Ministries. Copies of sermons (visual, audio & typescript format) tests and assignments are subjected to copyright and therefore prohibited
| Sermon by Prophet Kobus van Renburg |
Genesis 1:26,28 (KJV) And God said, Let us make man in our image, after our likeness: and LET THEM HAVE DOMINION over the fish of the sea, and over the fowl of the air, and over the cattle, and over all the earth, and over every creeping thing that creeps upon the earth.
And God blessed them, and God said unto them, "Be fruitful, and multiply, and replenish the earth, and SUBDUE IT and HAVE DOMINION over the fish of the sea, and over the fowl of the air, and over every living thing that moves upon the earth.
God gave them dominion twice and the second time He told them to subdue creation. To "subdue" something means to rule and to bring it under authority.
Genesis 2:8 (KJV) And the LORD God planted a garden EASTWARD in Eden; and there he put the man whom he had formed.
There was a place called, Eden and God planted a garden there in the east.
Genesis 2:15 (KJV) And the LORD God took the man, and put him into the garden of Eden to dress it and to KEEP IT.
God made man in His Image and in His likeness and told him to rule over everything that moves. That includes everything that creeps, flies, walks, crawls and swims. God then told them to eat of every tree in the garden except the one in the middle of the garden. In Genesis 3 the serpent came (he creeps and moves), but Eve did not subdue the devil neither did she rule over him. God told them to guard the garden, tend it and keep it. They had to watch over the garden so that no one steals it away from them. They had to keep it so that it would stay it the state God gave it to them. The way they had to do it was to rule over every moving thing. Instead of subduing the serpent, she started to converse with him.
Genesis 3:1 (KJV) Now the serpent was more subtle than any beast of the field which the LORD God had made. And he said unto the woman, Yea, hath God said, You shall not eat of every tree of the garden?
Genesis 3:8 (KJV) And they heard the voice of the LORD God walking in the garden in the cool of the day: and Adam and his wife hid themselves from the PRESENCE OF THE LORD God AMONGST THE TREES of the garden.
The Presence of the LORD was amongst the trees. The trees were in the garden and the garden was in Eden, in the east.
Genesis 3:9-11 (KJV) And the LORD God called unto Adam, and said unto him, Where art thou? And he said, I heard thy voice in the garden, and I was afraid, because I was naked; and I hid myself. And he said, "Who told thee that thou was naked? Have thou eaten of the tree, whereof I commanded thee that thou should not eat?"
God didn't tell them that they were naked. In Revelation 3:18 God came amongst the churches and told John that the people could get clothes to cover their nakedness. They lost their clothing in the garden and when man finds his way back into the garden, he can be clothed again and have the shame of their nakedness covered. In the beginning they lost their clothing and in the end they can get it back.
Genesis 3:24 (KJV) So he drove out the man; and he placed at the EAST of the garden of Eden Cherubims, and a flaming sword which turned every way, to KEEP THE WAY of the tree of life.
Man was driven out of the garden and a sword to protect the tree of Life, which is in the east of the garden, which is in the east in Eden, was placed there. Angels were commanded to guard the way to the tree of Life. Adam told God that he was hiding from His Presence when God looked for them.
During the exodus from Egypt, Moses said that they would go nowhere except His Presence goes with them. Moses asked God how they would know that His Presence is with them and God instructed him to build a tabernacle with a door, which is called, the way. This door led to the outer court. Then a tent was set up inside with two portions. The one was called the Holy Place and the other portion was called the Most Holy Place. A thick curtain separated that portion and no one could go in there except the high priest and that, only once a year. When they pitched the tent or tabernacle, God appeared in the Most Holy Place in all His Glory. They always pitched the tabernacle in the same way. God told them to pitch it so that the entrance was always to the east. The twelve tribes of Israel had to stand around the tabernacle three on each side and the tribe in front of the gate was "Judah" which means, "praise". Psalm 100 says that we shall enter His gates with thanksgiving and His courts with praise. The tabernacle was a shadow of what was and what is to come. God showed Moses a type of what He wanted. He wants to live in and amongst His people.
Man was driven out of the garden and from the Presence of God. The way to the tree of Life, which was in the east, was guarded by cherubim. God gave the Israelites a temporary tabernacle and they had to pitch it with its entrance to the east. The Word declares that from the rising of the sun to going down of the sun the LORD'S Name shall be praised. The sun rises in the east. So from the beginning to the end you must be in thanksgiving and in praises.
Revelation 21:3 says that the tabernacle of God is now with man. The way is now open into the temple of God.
Hebrews 4 & 10
tells us that we can now go boldly into the Most Holy Place.Revelation 22:1-2 refers to the Throne where the tree of Life is. Although the way is now open to the tree of Life and the tabernacle is now with man, all do not have it. A revelation is needed about the fact that we must rule. When man did not rule and reasoned, power, glory and the Presence of God was lost in their lives.
Genesis 4:7 (KJV) If thou do well, shall thou not be accepted? And if thou do not well, sin lies at the door. And unto thee shall be his desire, and thou shall RULE OVER HIM.
The devil brought sin into the world and God told Cain to rule over him. Satan is the personification of sin. He moved and talked to Eve. She had to rule over him. Although Adam and Eve received clothes from God, they were still naked in the spirit according to Revelation 3. When they were driven out of the garden and had children, Cain murdered his brother and God told him that sin will lie at his door and that he must rule over him. Romans 6:12 says that sin must not rule in your mortal bodies. In John 13 Jesus says that the devil comes, but he has no part in Him. In John 16:33 Jesus said to the disciples that they must not fear because He has overcome. Jesus said that the ruler of the world came, but because he had no part in Him; He ruled over him. Jesus took back what Adam and Eve lost in the garden (Jesus was not yet crucified).
John 16:33 (Amplified) I have told you these things, so that in Me you may have [perfect] peace and confidence. In the world you have tribulation and trials and distress and frustration; but be of good cheer [take courage; be confident, certain, undaunted]! For I HAVE OVERCOME THE WORLD. [I have deprived it of power to harm you and have conquered it for you.]
Man lost the Presence of God, but in Psalm 91:1 Moses said that he who dwells in the secret place of the Most High shall again abide under the shadow of the Almighty. Psalm 91:10 says that if you get there under the wings, no evil shall befall thee. The cherubim were protecting the tree of Life. When the ark was built that was in the Most Holy Place in the tabernacle, there were two cherubim on the top with their wings overshadowing the mercy seat. They guarded the Presence of God there on the mercy seat.
John 17:6 (Amplified) I have manifested Your Name [I have revealed Your very Self, Your real Self] to the people whom You have given Me out of the world. They were Yours, and You gave them to Me, and they have obeyed and KEPT YOUR WORD.
God spoke to man in the garden and told him to keep it. They just had to listen to the Word that God spoke. God spoke to them verbally and they had to keep His Words. If you keep it, it is yours. They didn't keep it, lost it and were driven out of the Presence of God. When Jesus prayed, He said that He manifested the Name of the Father to them through the miracles, the teachings and preaching. Everything Jesus did was because of Him Who sent Him. He only did what the Father said and He didn't do anything in His own Name. The Father gave Him some out of the world and they kept His Word. At this time, Jesus hadn't died yet and they hadn't done anything yet.
John 17:11-17 (Amplified) And [now] I am no more in the world, but these are [still] in the world, and I am coming to You. Holy Father, KEEP in Your Name [in the knowledge of Yourself] those whom You have given Me, that they may be one as We [are one]. While I was with them, I KEPT and PRESERVE THEM IN YOUR NAME [in the knowledge and worship of You]. Those You have given Me I GUARDED and protected, and not one of them has perished or is lost except the son of perdition [Judas Iscariot-the one who is now doomed to destruction, destined to be lost], that the Scripture might be fulfilled. [Psalm 41:9; John 6:70]. And now I am coming to You. I say these things while I am still in the world, so that My joy may be made full and complete and perfect in them [that they may experience My delight fulfilled in them, that My enjoyment may be perfected in their own souls, that they may have My gladness within them, filling their hearts]. I HAVE GIVEN and delivered to THEM YOUR WORD (message) and the world has hated them, because they are not of the world [do not belong to the world], just as I am not of the world. I do not ask that You will take them out of the world, but that YOU WILL KEEP and protect THEM FROM THE EVIL ONE. They are not of the world (worldly, belonging to the world), [just] as I am not of the world. Sanctify them [purify, consecrate, separate them for Yourself, make them holy] by the Truth; YOUR WORD IS TRUTH.
There are two things that Jesus said. Keep the Word and keep the people. They keep the Word and then God keeps them. Jesus manifested the Name of the Father to them because they kept the Word. Jesus gave them the Word of the Father and that Word is the Truth. If they keep the Word that is Truth, the Father will keep them from the world and evil. The devil is a liar and lied to man in the garden. Jesus asked the Father not to take them out of the world, but to keep them and that His Name was to be manifested to them as they keep the Word by keeping them from the devil.
John 8:29-32 (Amplified) And He Who sent Me is ever with Me; My Father has not left Me alone, for I always do what pleases Him. As He said these things, many believed in Him [trusted, relied on, and adhered to Him]. So Jesus said to those Jews who had believed in Him, If you ABIDE IN MY WORD [KEEP MY WORD] [hold fast to My teachings and live in accordance with them], you are truly My disciples. And you will know the Truth, and the Truth will set you free.
If you stay in the Word, which is Truth, the truth of the Word that you keep will set you free. If you are living in the freedom of the Word that set you free, the Father will honor His Name and keep you from evil, sin and the devil. It is not how you fight the devil, but how the Father will keep you from the devil. It is not how strong you are, but God Who keeps you. You have found your way back to the Presence and the Glory of God.
Between the place where man had authority and lost it and where God restored man's rule, there was a shadow of a tabernacle. As long as the shadow stood, man could not find his way to God (Hebrews 9). Since the true tabernacle came, we don't need the shadow anymore. Jesus went into the heaven into the tabernacle that was not made with hands and He went in with His own blood to open the way. Now we can boldly enter.
Hebrews 6:19-20 (Amplified) [Now] we have this [hope] as a sure and steadfast ANCHOR of THE SOUL [it cannot slip and it cannot break down under whoever steps out upon it-a hope] that reaches farther and enters into [the very certainty of the Presence] within the veil, [Leviticus 16:2]. Where Jesus has entered in for us [in advance], a FORERUNNER having become a High Priest forever after the order (with the rank) of Melchizedek. [Psalm 110:4].
Hebrews 4:14-16 says that we can boldly come to the Throne of Grace. Hebrews 10:19 says that we can boldly enter the Holy of Holies. Jesus opened the real tabernacle by becoming The Way. In John 14 Jesus said that He was going to prepare a place for them, that He was going to the Father and that they knew the way. When they asked Him the way, He said that He is the Way. You can only come to the Father through Jesus. Jesus was the Forerunner Who went into the Most Holy Place. He is the Anchor for our souls. Your mind does not have to collapse or have to burn out. You do not have to be stressed or depressed. In the Presence there is an Anchor for our souls and there you find rest when you come to Him. We must renew our minds (which will get our souls right) by receiving with meekness the implanted Word that can save our souls (James 1:21).
We have the Anchor, but it is behind the veil in the Presence of God. Jesus went in as a Forerunner to open the way and became the way. Now Jesus says that we must follow Him. The way to the tree of Life is open. God wants us to live in His Presence.
In the beginning God made the earth and He made a place called Eden. In that place He planted a garden. In the middle of the garden He planted the tree of Life, which is Jesus. Then He made man in His likeness and put them in the garden. He told man to keep and guard the garden and to rule over everything that moves. The serpent came (he moved) and he told lies. Man did not rule, but reasoned with him. Then man was driven out of the garden and an angel guarded the way to the tree of Life. God told Moses that He wanted His Presence back with man and man back in His Presence. Then he made a shadow of things that was and was to come. He made the tabernacle with its way into it to the east. People had to come in with thanksgiving and praise. The tabernacle had a tent, called the Most Holy Place where the Presence of God came on the mercy seat of the ark, which were protected by cherubim. Jesus came and opened the real Way to the real tabernacle and it is now with man.
2 Corinthians 6 says that God wants to dwell with us and us with Him. Your mind is the thing that keeps you away from the Presence, because sin lies at your door and want to rule over you. But man must rule over it. Jesus gave us His Word, which is Truth. If you abide in the Word, you know the Truth and that Truth will set you free. When you keep the Word, God will manifest His own Name by keeping you from evil, sin and the devil. When God wanted to destroy Israel in the desert, Moses reminded God of His Name. God manifests Himself to us by keeping us from evil. Jesus prayed that the Father's Name must be hallowed by delivering us from evil and He prayed that we must be in the world, but that the Father must keep us from the evil one. Jesus gave the Word and we must keep the Word. When we keep the Word, we will know the Truth and that Truth sets us free. When we walk in freedom His Name is manifested because the Father will keep us from the evil one.
Revelation 1:10 (Amplified) I was in the Spirit [rapt in His power] on the Lord's Day, and I heard behind me a great voice like the calling of a war trumpet…
John was caught up into the Presence of God. He saw the Throne and all the glory. Then he heard a voice behind him and turned around – his back was therefore to the Throne.
Revelation 1:12,20 (Amplified) Then I turned to see [whose was] the voice that was speaking to me, and on turning I saw seven golden lampstands…
As to the hidden meaning (the mystery) of the seven stars, which you saw on My right hand and the seven lampstands of gold: the seven stars are the seven angels (messengers) of the seven assemblies (churches) and the seven lampstands are the seven churches.
When John turned around he saw Jesus walking in the midst of the churches. The churches were not where John was. They were outside the place where God wanted them to be. That is why God gave John the visions to write to the churches. Revelation is an admonishing, a warning and guideline to get to into the Presence. The evil cannot touch you there, even though you are still in the world. Jesus prayed to the Father that He must not take them out of the world, but keep them. People taught the church to get out of the world, but God wants us to rule in this world with Christ to prove to the world the overcoming power of Jesus.
Jesus gave His Word and told us to keep it and the Father will keep us from evil. John was in the Presence, but the church was outside. Jesus was walking in the midst of the churches. Jesus was not manifesting Himself there, but He was telling them to repent and how to get back into the Presence. He was telling them how to overcome. In John 16:33 Jesus told the disciples not to worry about the world, because He overcame. There is an overcoming life in the world that will take them to where they are supposed to be.
Revelation 2:7 (Amplified) He who is able to hear, let him listen to and give heed to what the Spirit says to the assemblies (churches). To HIM WHO OVERCOMES (is victorious), I will grant to eat [of the fruit] of the tree of life, which is in the paradise of God.
Jesus talks about the one that overcomes in the world and not the one that dies and goes to heaven. We must learn to keep the Word, so that we can be protected against the evil one and live an overcoming life.
Revelation 2:11,17 (Amplified) He who is able to hear, let him listen to and heed what the Spirit says to the assemblies (churches). He who OVERCOMES (is victorious) shall in no way be injured by the second death.
He who is able to hear, let him listen to and heed what the Spirit says to the assemblies (churches). To him who OVERCOMES (conquers), I will give to eat of the manna that is hidden, and I will give him a white stone with a new name engraved on the stone, which no one knows or understands except he who receives it.
Manna was one of the things that were in the Ark that was in the Most Holy Place. Everything that you get when you overcome is something that was hidden behind the veil in the Presence of God.
Revelation 2:25-26 (Amplified) Only hold fast to what you have until I come. And he who OVERCOMES (is victorious) and who obeys My commands to the [very] end [doing the works that please Me], I will give him authority and power over the nations.
Revelation 3:21-22 (Amplified) He who OVERCOMES (is victorious), I will grant him to sit beside Me on My throne, as I Myself overcame (was victorious) and sat down beside My Father on His throne. He who is able to hear, let him listen to and heed what the [Holy] Spirit says to the assemblies (churches).
Revelation 4:1-2(a) (Amplified) AFTER THIS I looked, and behold, a DOOR standing OPEN in heaven! And the first voice which I had heard addressing me like [the calling of] a war trumpet said, Come up here, and I will show you what must take place in the future. At once I came under the [Holy] Spirit's power, and behold, A THRONE stood in heaven…
The open door is the Way that was opened by Jesus. When He called John to come up higher, He did not take him out of the world, but He called him to where He is: on the Throne.
Man was in the Presence of God in the garden and to stay there, they had to rule over every moving thing. They didn't rule and was driven out of His Presence. The angel then protected the Way to the Presence with a sword in the east. Moses built a shadow of the Presence of God. The door or way into it was in the east. When Jesus was crucified, He went into the Presence as a Forerunner and He became the Way and the Anchor in the Most Holy Place. He told us to follow Him. Jesus gave us His Word and asks us to keep it so that we will overcome. The Father manifests Himself to us by keeping us from evil because we keep the Word. When we overcome we are in the Presence again, eating from the tree of Life (the hidden manna, life in the glory) and are sitting on the Throne. We then rule again.
A king sits on the throne with a crown on his head. In Revelation 1:5 and 5:9 Jesus says that He washed us with His blood to make us kings to rule. We are not washed in the blood to be able to go to heaven one day when we die. We are washed in the blood to be kings to rule. We are supposed to rule on this earth and in this world. When we overcome, we shall sit on the throne again and rule. Adam lost everything. Jesus showed us how to overcome and get everything back.
James 1:2 (Amplified) Consider it wholly joyful, my brethren, whenever you are enveloped in or ENCOUNTER trials of any sort or fall into various TEMPTATIONS.
When temptation comes and you know that you have an Anchor and God keeps you, while you keep the Word, nothing can overcome you, but you will overcome temptation.
James 1:3 (Amplified) Be assured and understand that the trial and proving of your faith bring out endurance and steadfastness and patience. But let endurance and steadfastness and patience have full play and do a thorough work, so that you may be [people] PERFECTLY and fully developed [with no defects], LACKING IN NOTHING.
When temptation comes it is to teach you to have patience and that is overcoming. When patience has its perfect work, you will be perfect and entire and not want anything. There is nothing that you need when you are in the Presence of God.
James 1:12 (Amplified) Blessed (happy, to be envied) is the man who is patient under trial and STANDS UP under temptation, for when he has stood the test and been approved, he will receive [the victor's] CROWN of life which God has promised to those who love Him.
When you stand under temptation, you are an overcomer. When you endure temptations with patience, you will get your crown back. When you get your crown, you are on the throne and you rule; you are back in the Presence.
Revelation 3:8 (Amplified) I know your [record of] works and what you are doing. See! I have set before you a DOOR WIDE OPEN which no one is able to shut; I know that you have but little power, and yet you have KEPT MY WORD and guarded My message and have NOT RENOUNCED or denied MY NAME.
The open door referred to is Jesus and not an opportunity. Jesus is the Door and the Way.
Revelation 3: 9-12 (Amplified) Take note! I will make those of the synagogue of Satan who say they are Jews and are not, but lie-behold, I will make them come and bow down before your feet and learn and acknowledge that I have loved you. [Isaiah 43:4; 49:23; 60:14]. Because you have guarded and KEPT MY WORD of PATIENT ENDURANCE [have held fast the lesson of My patience with the expectant endurance that I give you. I also will KEEP YOU [SAFE] from the hour of trial (testing), which is coming on the whole world to try those who dwell upon the earth. I am coming quickly; HOLD FAST TO WHAT YOU HAVE, so that no one may ROB YOU and deprive you of your CROWN. He who OVERCOMES (is victorious), I will make him a pillar in the SANCTUARY of My God. He shall NEVER BE PUT OUT OF IT or go out of it, and I will WRITE ON HIM THE NAME OF MY GOD and the name of the city of My God, the new Jerusalem, which descends from My God out of heaven, and My own new name.
Let no one take your crown again! If you have found the open door and passed through it and you keep the Word, God will keep you from temptations. Don't let moving things take your crown again. God will make you a pillar in the sanctuary and never put you out of it; you will stay in His Presence. An anchor of your soul means a steadfastness that comes with patient endurance. That comes when you keep the Word of God. He will honor His Word and keep you from evil. God will make you a pillar or a foundational thing in His Temple. God dwells in us and not in man made temples. You will not be able to go out of His Presence.
When a pillar of a building is taken out, the building collapses. The person that found the Door or the Way (Jesus) and overcomes is a pillar in the temple of God. If you are a pillar you cannot go out again. When John looked around and saw the church outside, he called them to come in. He showed them the Door and when they come in, they'll find the throne where they are supposed to sit.
If you are a pillar, no devil can get you there. A pillar cannot go out of the sanctuary ever again. Overcome by keeping the Word. You do not have to fight devils. God will keep you. You will stay in His Presence. If you are a pillar and someone wants to touch you, he has to come inside. In the sanctuary there are guardian angels that guard the tree of Life and when you are there, they protect you. There you get your crown and you rule and nothing will be able to touch you or harm you. Psalm 91 says that he who dwells in the secret place of the Most High, shall abide under the shadow of the Almighty and there shall no evil befall him. Angels will protect you and you will find length of days. We rule in this life with One, Christ Jesus (Romans 5:17).
Jesus prayed that we will be one as They are One and that He will be in us and us in Him. When we have this truth, God will keep us and inside of Him there is no devil that can touch us. Our lives are hidden with Christ in God.
Ecclesiastes 10:7 says that there is an error, which needs to be put right and that is the slaves that ride on horses and princes that are walking. The rulers need to be riding again and the slaves need to walk. Revelation 19:11 says that when John saw the heaven opened, he saw Jesus on a white horse with an army behind Him on white horses. This army is us. Psalm 110 says that we shall rule in the midst of our enemies and the people shall be willing in the day of His power, to rule. That is the High Priestly order.
In Matthew 9:18-30 a certain ruler came to Jesus and asked Him to lay His hands on his daughter that just died. When Jesus came to the house, He let all the people go out except the one that knew how to rule. He already said that Jesus must just lay His hands on her and she shall live. In Matthew 8:5-13 a centurion, which is a ruler over hundred came and asked Him to heal his servant and he told Jesus to just speak a Word. You must understand rulership. He just had to speak a Word and they would listen. In John 3 a ruler came to Jesus and told Him that they knew that He was from God, because no one could do these signs except it comes from God.
Isaiah 55:10-11 says His Word is like rain. It shall do what it is sent for and it shall not return void to Him. In Luke 2 Mary said to the angel that it must be done to her according to His Word. With God nothing is impossible. Every Word of God shall be fulfilled. Keep the Word and it will keep you. You do not have to keep the garden, but the Word. If you keep the Word, God will see to it that you will get back to the garden. If you are there, God will see to it that you are kept from the evil one.
Spirit Word Ministries
P.O. Box 10344
South Africa
Phone: +27 (0) 18 484 4351 / 6940
Fax: +27 (0) 18 4843482 / 5423
E-Mail: email@example.com
@spirit Word. Terms & Conditions apply.


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So I just had some pinkish blood. I'm freaked. U/s already scheduled for Monday. Would you just wait until then unless it gets worse???
5:46pm - nothing since that first incident. I think/hope I just did too much. Going to take it easy this weekend, relax as much as I can with two toddlers!


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