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This study evaluated the relationship between skin intrinsic fluorescence (SIF) and long-term mean hemoglobin A1c (HbA1c) in individuals with type 1 diabetes.
We undertook a cross-sectional analysis of 172 individuals with type 1 diabetes followed longitudinally with HbA1c data available over an average of 16.6 years. SIF was evaluated cross-sectionally using the SCOUT DS® device (VeraLight Inc., Albuquerque, NM) and correlated with most recent HbA1c and long-term mean HbA1c. Potential determinants of this relationship, including age, gender, smoking status, duration of diabetes, and renal function, were also evaluated.
Age-adjusted skin intrinsic fluorescence significantly correlated with long-term mean HbA1c (R=0.44, P<0.0001). In contrast, there was no significant relationship between SIF and most recent HbA1c (R=0.14, P=0.075). The best-fit model describing the relationship between SIF and mean HbA1c controlled for factors of age, duration of disease, renal function, and site of study conduct. Controlling for these factors was also important in understanding the relationship between most recent HbA1c and SIF. Evaluating longer-term HbA1c data also strengthened the relationship between SIF and mean HbA1c. In the presence of renal dysfunction or damage, as indicated by an estimated glomerular filtration rate of <60mL/min/1.73m2 or presence of gross proteinuria, there was no significant correlation between SIF and mean HbA1c.
Noninvasive detection of SIF significantly correlates with long-term mean HbA1c, providing insight into long-term glycemic exposure. Age, duration of diabetes, and renal function are potential contributors to this relationship.
Chronic exposure to hyperglycemia contributes to the pathogenesis of diabetes-related complications. Long-term prospective studies such as the Diabetes Control and Complications Trial (DCCT)1 and the United Kingdom Prospective Diabetes Study (UKPDS)2 have demonstrated the utility of assessing glycemic exposure, for example, by mean hemoglobin A1c (HbA1c) over time,2 in determining risk of diabetes-related complications. In the DCCT, there was a continuously increasing risk of progression of retinopathy with increasing mean glycosylated hemoglobin values.1 In the UKPDS, every percentage point drop in mean HbA1c over time was associated with a reduction in microvascular complications by 37% and a reduction in the risk of any end point or death related to diabetes by 21%.2
Few medical clinics have complete records of measured glycated hemoglobin over many years. They instead rely on single recent measurements of HbA1c, which only provide information about glycemic exposure over the preceding 2–3 months.
An alternative method of understanding cumulative historical glycemic exposure is based on the role of advanced glycation end products (AGEs). AGEs accumulate naturally with aging but accumulate faster in individuals with abnormal glucose regulation.3 With increased glucose exposure, glycated and glycoxidated proteins form early and intermediate glycation products such as HbA1c as well as stable AGEs that accumulate in skin and in tissues affected by diabetes. Conveniently, AGEs are also stably bound to skin collagen, which has an estimated half-life of 15–20 years.4 Therefore, skin levels of AGEs are able to provide historical information about chronic exposure to hyperglycemia and may predict future progression of diabetes-related complications. Indeed, several studies, including the DCCT and the Epidemiology of Diabetes Interventions and Complications Study, have shown that elevated levels of skin AGEs are predictive of future development and progression of diabetes-related complications.5,6
Skin AGEs can be assessed noninvasively by exciting and measuring fluorescence produced by the AGEs in vivo. Using noninvasive technology, another study following over 800 participants with type 2 diabetes for 3.1 years demonstrated a correlation between baseline noninvasive skin autofluorescence and diabetes-related microvascular complications, including neuropathy or microalbuminuria.7
In this study, we cross-sectionally evaluated the skin intrinsic fluorescence (SIF) of participants with type 1 diabetes with HbA1c data available over a mean duration of 16.6 years. We hypothesized that noninvasive SIF would be correlated with mean HbA1c over time and further sought to explore the potential role of factors such as age, gender, smoking status, duration of diabetes, and renal function on this putative relationship.
Participants were enrolled in this cross-sectional evaluation from two sites: the University of Pittsburgh (Pittsburgh, PA) and MedStar Health Research Institute (MHRI) (Hyattsville, MD). Participants from the University of Pittsburgh were included from the longitudinal observational Pittsburgh Epidemiology of Diabetes Complications (EDC) cohort,8,9 where skin fluorescence was assessed in their 20th year of follow-up, 2 years after routine clinical and laboratory assessment, and participants from MHRI were recruited and enrolled from patients receiving their diabetes care from MHRI's investigator (R.E.R.) or immediate colleagues. Participants were excluded for any wounds, injuries, or rashes on the volar forearm that could potentially interfere with skin fluorescence assessment. Other exclusions included current receipt of other investigational treatments, current receipt of medications that may alter skin fluorescence or photosensitivity, pregnancy, or inability to follow study procedures. No specific intervention was directed at the participants prior to evaluation of skin fluorescence, but rather participants were evaluated in the context of their usual care and follow-up. All procedures for this cross-sectional evaluation were reviewed and approved by the Institutional Review Board of the University of Pittsburgh and the MHRI Institutional Review Board, respectively. All participants provided written informed consent prior to any study procedures. Medical history and physical examination were performed. Criteria for inclusion in the analysis included availability of historical HbA1c data for a minimum of 4 years prior to skin fluorescence measurement.
Blood samples were assayed for HbA1c and serum creatinine. DCCT-aligned HbA1c values were used to calculate the mean HbA1c. For the EDC investigative population, the level of stable glycated hemoglobin A1 (HbA1) was originally measured in saline-incubated samples by microcolumn cation-exchange chromatography (Isolab, Akron, OH). On October 26, 1987, the method was changed to high-performance liquid chromatography (Diamat®; Bio-Rad Laboratories, Hercules, CA). The two methods were highly correlated (r=0.95; Diamat HbA1=0.18±1.00 Isolab HbA1). Beginning in 1998, HbA1c was measured using the DCA2000 analyzer (Bayer Diagnostics, Tarrytown, NY). Original HbA1 (1986–1998) and HbA1c (1998–2004) were converted to DCCT-aligned HbA1c values using regression formulas derived from duplicate analyses: DCCT HbA1c=(0.83×EDC HbA1)+0.14 or DCCT HbA1c=(EDC HbA1c – 1.13)/0.81.8 For the MHRI diabetes clinic, HbA1c was obtained with DCCT-aligned DCA 2000/DCA 2000+instruments or by DCCT-aligned laboratory values from local laboratories, and historical HbA1c values were captured through detailed chart review.
Exposure to glycemia was determined in a manner similar to that used in the UKPDS,2 with exposure to glycemia over time measured as an updated mean of historical measurements of HbA1c, referred to here as mean HbA1c. This was calculated by taking the sum of an individual's HbA1c values over the duration of follow-up and dividing by the number of HbA1c measurements taken for that individual. Another indicator of cumulative glycemic exposure, A1 months, was calculated by multiplying the number of HbA1 units above normal at each cycle by the number of months between the midpoints of the preceding and succeeding cycle intervals.10 Level of albuminuria was determined by timed urine collections (EDC) or spot urine collections (MHRI). Gross proteinuria was defined as two or more timed urine collections with albumin excretion rate of >300μg/min (EDC) or spot urine albumin:creatinine ratio of >300mg of albumin/g of creatinine (MHRI). Glomerular filtration rate was determined by the Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula.11
SIF was determined noninvasively on the left volar forearm of all participants using the investigational SCOUT DS® skin fluorescence spectrometer (VeraLight, Inc., Albuquerque, NM). Two measurements were repeated consecutively approximately 1min apart. All measurements were done without regard to the timing of meals. A calibration check was performed before each SCOUT DS subject measurement. Skin fluorescence was excited with a light-emitting diode centered at 405nm and was detected over the range of 441–482nm. The skin reflectance was measured over both the excitation and emission regions and was used to compensate for absorbance caused by melanin and hemoglobin.9,12 The intrinsic fluorescence correction is expressed in Eq. 1:
where measured fluorescence, Fxm, is divided by reflectance values at the excitation and emission wavelengths, Rx and Rm, respectively.12 The reflectance values are adjusted by the respective dimensionless exponents, kx and km. As in previous reports regarding associations of SIF with neuropathy and coronary artery disease in this cohort, kx was set to 0.9, km was set to 0.0, and the resulting intrinsic fluorescence, fxm, was integrated over the 441–482-nm spectral region to give the SIF (in arbitrary units).9,13 The Hoorn coefficient of variation of SIF, quantifying the intrasubject variance, was previously reported at 4%.14
Baseline characteristics of the study population were calculated both overall and by site. Student's t tests and the χ2 test were used to compare characteristics between study sites. SIF was log normally distributed and therefore transformed by natural logarithm for all subsequent statistical analyses. Multiple linear regression analyses were used to determine the association between both mean HbA1c and the most recent HbA1c to SIF. Variables factored into the regression analyses included age, duration of disease, follow-up length, serum creatinine, evidence of proteinuria, site of study, gender, race, and smoking exposure. The β coefficients were expressed with 95% confidence intervals to illustrate both effect size and statistical significance. We tested for interactions with age, duration of disease, and follow-up length. Variance inflation factors were calculated to check for multicollinearity. Model discrimination was assessed with both the use of R2 values and Akaike Information Criteria. Period intervals of HbA1c values (0–5 years, 0–10 years, 0–15 years, 0–20 years) were assessed into the best-fit model to evaluate the relationship between SIF and HbA1c over time. Statistical tests were performed using SAS version 9.1 (SAS Institute, Cary, NC), and scatterplot/regression lines were created using STATA version 10.1 (STATA Corp., College Station, TX).
Baseline characteristics of the studied population are presented in Table 1. In total, 172 participants with type 1 diabetes were evaluated. Mean age was 48.9 years, and mean duration of diabetes was 36.1 years. Average length of follow-up was 16.6 years. Mean HbA1c was higher than most recent HbA1c at 8.4% versus 7.7%, respectively (P<0.0001). When evaluated by site, participants enrolled at Pittsburgh from the EDC population demonstrated a longer duration of disease (40.1 vs. 28.6 years, P<0.0001) and were followed up for a longer length of time (20 years vs. 10.27 years, P<0.0001) compared with participants enrolled in the MHRI diabetes clinic. Similarly, participants enrolled at Pittsburgh from the EDC population demonstrated a higher mean HbA1c value (8.77% vs. 7.83%, P<0.0001) and higher SIF measurement than participants enrolled in the MHRI diabetes clinic.
As shown in Figure 1A, log SIF significantly correlated with age (R=0.46, P<0.0001). As shown in Figure 1B, log SIF adjusted for age significantly correlated with mean HbA1c (R=0.44, P<0.0001). Likewise, A1 months, another indicator of chronic glycemic exposure,10 was significantly correlated with log SIF (R=0.31, P<0.0001). In contrast, a single, most recent measurement of HbA1c, as an indicator of glycemic exposure in a limited period of the preceding 2–3 months, did not correlate with log SIF (R=0.14, P=0.075).
To explore potential contributions to the relationship between SIF and HbA1c, several models were assessed. As shown in Table 2A, the lowest Akaike Information Criteria value, indicating the best-fit model between mean HbA1c and SIF, was seen when we controlled for age, duration of disease, creatinine, and site. Race and smoking exposure had nonsignificant contributions to the model (data not shown). Gross proteinuria and creatinine demonstrated high collinearity; thus creatinine was used in the final model. Unlike with mean HbA1c, most recent HbA1c demonstrated no significant relationship with SIF. However, controlling for factors of age, duration of disease, creatinine, and site, as seen in the best-fit model (Table 2B), demonstrated a significant relationship between recent HbA1c and SIF.
To evaluate the duration of HbA1c-related glycemic exposure captured by SIF, we then modeled the relationship between mean HbA1c and SIF while controlling for mean HbA1c measurements available for prespecified time intervals (0–5 years, 0–10 years, 0–15 years, 0–20 years) in a subcohort of participants followed up for the full 20 years (n=103). We found the strongest magnitude of effect when HbA1c values were factored in over a 20-year period (β coefficient 0.089, 95% confidence interval 0.046–0.132), with the weakest magnitude seen between mean HbA1c and SIF when HbA1c values were only included 0–5 years prior to SIF measurement (β coefficient 0.066, 95% confidence interval 0.028–0.103). These findings were corroborated with a univariate lag analysis using 5-, 10-, 15-, and 20-year time points (data not shown).
As serum AGEs are cleared by the kidneys, the effect of renal dysfunction and renal damage on the relationship between SIF and long-term mean HbA1c was evaluated. Results are tabulated in Table 3. In the presence of advanced stages of renal damage, as evidenced by gross proteinuria or declining renal function by estimated glomerular filtration rate (eGFR), there is no significant correlation between log SIF and mean HbA1c. Log SIF significantly correlates with mean HbA1c in the absence of gross proteinuria (R=0.46, P<0.0001, n=134) but does not in the presence of gross proteinuria (R=0.15, P=0.39, n=35). Similarly, in individuals with eGFR<60mL/min/1.73m2, there is no significant correlation between log SIF and mean HbA1c (R=0.25, P=0.11, n=43), whereas there is a significant relationship in those with an eGFR>60mL/min/1.73m2 (R=0.48, P<0.0001, n=128).
Chronic exposure to hyperglycemia contributes to the accumulation of early and intermediate glycation products, including HbA1c, and to AGEs, which may be related to the development of diabetes-related complications.15,16 In this cross-sectional analysis, we demonstrated that SIF, a marker of AGE accumulation, is significantly and positively associated with long-term mean HbA1c. The strongest magnitude of a relationship was seen when factors of age, duration of diabetes, renal function, and site of study were controlled for in the statistical models. Modeling also indicated that availability of longer-term HbA1c data contributed to a greater magnitude of relationship between SIF and mean HbA1c.
These observations are consistent with the underlying physiology of glycation and AGE accumulation.5,17–20 AGEs are formed from nonenzymatic glycation of tissue proteins and are found in a variety of tissues, including skin, tracheal cartilage, tendons, ligaments, cortical bone, aorta, cardiac muscle, lung, liver, kidney, lens, red blood cells, and blood proteins.17 In skin biopsy studies, Dyer21 previously showed that concentrations of AGEs such as N'-(carboxymethyl)lysine and pentosidine, as well as AGE-associated skin fluorescence, increase in human skin collagen with age and that the rate of their increase is accelerated in diabetes. This author also reported a strong correlation (R=0.89, P<0.0001) between skin collagen glycation content obtained by skin biopsy in type 1 diabetes and mean percentage glycation of hemoglobin, reflective of glycemic control over the 6 years before skin biopsy.21 Here, too, we report a relationship between integrated glycemic exposure (mean HbA1c) and noninvasive measurement of SIF, with duration of diabetes contributing positively to this relationship.
Another study using the same technology in children with type 1 diabetes likewise demonstrated an association between SIF and mean HbA1c, after controlling for age, race, sex, z-score for body mass index, and duration of diabetes. In children with type 1 diabetes, just as in our adult population, SIF increased with age and correlated with mean HbA1c. It is interesting that in children there was also an influence of gender on SIF, with higher levels in females at all ages than males, which we did not find in our adult cohort. In this study by Felipe et al.,20 which had 29% black or African American participants, race was also an influence on SIF, with SIF levels being higher in blacks than in whites. In our model, ethnicity was not a significant contributor, although our population was predominantly white. The study by Felipe et al.20 found no significant association between mean blood glucose or mean blood glucose over time with SIF, suggesting factors other than mean blood glucose might influence nonenzymatic glycation and formation of AGEs.
Our findings of an absent relationship between log SIF and mean HbA1c at low eGFR or in the context of gross proteinuria are also consistent with AGE physiology. Increased serum and tissue levels of AGEs are seen in the context of end-stage renal failure, because of reduced removal by the kidneys.22 Thus, in the context of advanced kidney disease, the accumulation of AGEs with impaired clearance may limit the ability of SIF to discern the level of historical glycemic control. These findings and understanding the relationship between SIF and nephropathy warrant further exploration. Specific use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was not directly ascertained, which is a limitation of the analysis.
The ability to noninvasively measure AGE-associated fluorescence as a correlate, or indicator, of cumulative glycemic exposure provides a plausible approach to assess risk of diabetes-related complications. Several studies have already demonstrated the ability of skin fluorescence to detect and predict diabetes-related complications. Chabroux et al.23 published an independent association between skin fluorescence levels and diabetic nephropathy and neuropathy in type 1 diabetes, although this was not seen with retinopathy. In a prospective study of patients with well-controlled type 2 diabetes, after a mean follow-up of 3.1 years, patients with a higher baseline skin fluorescence reading had a higher likelihood of developing microalbuminuria or neuropathy, but again not retinopathy.7 Conway et al.9 demonstrated that SIF was even more strongly associated with the presence of autonomic neuropathy and confirmed distal symmetrical polyneuropathy than mean HbA1c.
There also appears to be an association between skin fluorescence and risk of macrovascular complications. In a prospective study, baseline skin fluorescence was an additive predictor to the UKPDS risk engine in determining risk of subsequent cardiovascular events in patients with type 2 diabetes.24 An association between coronary artery calcification and noninvasive SIF measurement has also been reported in participants with type 1 diabetes from the EDC study.14
There are several potential limitations to this study. One potential limitation to this study is differences in the participant populations recruited from the two collaborative sites for this evaluation. When compared directly, gender, recent HbA1c, and creatinine did not differ between the two sites, whereas duration of diabetes and length of follow-up did. To minimize any bias from the differences in study settings, only data that were similarly obtained by both populations (e.g., SIF measurements) or able to be standardized (e.g., clinical assessment, HbA1c, renal function) were decided upon prior to the pooled analysis. Potential differences in the populations recruited at each site were also accounted for in the statistical models, controlling for factors such as age, gender, ethnicity, smoking exposure, duration of diabetes, and renal function, as well as site of study. Additional potential limitations include the use of single spot measurements of the albumin:creatinine ratio as an indicator of proteinuria (MRHI), although there is precedent of doing so in large multicenter trials,25 and limited historical data are available on the use of angiotensin converting enzyme inhibitors to better understand the relationship between SIF and mean HbA1c in the context of renal dysfunction. Finally, this study focused on long-term mean HbA1c as an indicator of glycemia, comparable to that used in the UKPDS.2 However, other variables of interest to evaluate chronic glycemic exposure may have included mean blood glucose,20 which was not available for this study.
Our study uniquely evaluated and confirmed a significant relationship between SIF and long-term mean HbA1c in patients with type 1 diabetes with confirmatory HbA1c data of up to 20 years in duration. Mean HbA1c, as an indicator of long-term glycemic exposure,2 is often not available or feasible in the office setting, particularly when patients are not followed up regularly by a single provider/system. As an alternative to mean HbA1c, which may not be available, noninvasive assessment of SIF may provide insight to historical glycemic exposure. As an area for additional investigation, understanding cumulative glycemic exposure in this manner carries potential to further inform glycemia management and prevention of diabetes-related complications.
This work was supported by grant DK 34818 from the National Institutes of Health (to T.J.O.) and was in part conducted through the Georgetown–Howard Universities Center for Clinical and Translational Science and supported by the National Institutes of Health National Center for Research Resources, grant UL1RR031975 (to R.E.R. and V.R.A.). This project was funded in part by VeraLight, Inc. We would like to acknowledge the dedication and contributions of our participants and research staff.
V.R.A. and R.E.R. have received research grant funding from VeraLight Inc. and have served as consultants for VeraLight Inc. T.J.O. has received research grant funding from VeraLight Inc. N.I.M. and J.D.M. are employees and stock option holders of VeraLight Inc. B.N.C. and S.J.F. declare no competing financial interests exist. V.R.A. researched data, contributed to discussion, wrote/reviewed/edited the manuscript, and takes responsibility for the content of this article. B.N.C., S.J.F., T.J.O., and R.E.R researched data, contributed to discussion, and reviewed/edited the manuscript. N.I.M. and J.D.M. contributed to discussion and reviewed/edited the manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Throwback: KG in a Three Point – Shooting Contest???
- Updated: April 17, 2013
So I recently came across a youtube video that features KG and Paul Pierce in the McDonald's All American 3pt shooting contest and Dunk contest. You'd think the Truth would be in the 3pt contest and KG in the Dunk contest, right?
WRONG…the 6'11 center out of high school, Kevin Garnett, was selected to particpate in the three point contest and boy did he struggle! Although, KG has made 173 three pointers in his career, he was definitely not ready for this contest!!!
In the second part of the video, you see a much more athletic Paul Pierce throwing down some vicious slams!
Check out the video (credit to Celticslife):
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As a lifetime New England sports fan, Khai was determined in October of 2005 to finally start using that passion and determination to create the site now known as Celtics 24/7. Formerly known as Celtics Pride, Celtics 24/7 has become one of the most well-respected and followed Celtics websites. Our motto "For Fans, By Fans" rings entirely true as we've built and grown a community of passionate and enthusiastic Celtics fans. It all starts with you–the fans, and I appreciate every single person who supports us on our journey to the top.
Latest posts by Khai Pham (see all)
- Isaiah Thomas Narrowly Avoids Suspension - April 25, 2016
- Can The Celtics Make a Run In The Playoffs? - February 26, 2016
- Isaiah Thomas Key To Celtics Capturing Atlantic Division Title - February 26, 2016

subset: commoncrawl


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If you have troubles since the update to WordPress 4.5 please read this post before opening a new thread.
Is there a way to get the homepage slider to play the image in a random order ? So that it's not the same order every time you visit the website ?
Paul L.
Hi Paul,
This feature is not available. You can check this (Purchase code hidden if logged out) -images">link as a reference.
Ok thanx i understand!, it would be a great update though! :-)
The topic 'Random order of homepage slider?' is closed to new replies.


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Answers (1)
Hi Punky,
If all has been taken in consideration (ie. light struck, moisture etc)I think I would talk to the manufacture, as cheaper drugs detoriate much faster. Call and give the stock id# to them all the info. you have about your storage and they might be able to give you a good idea.
Sorry I can not be more definative on this.
Wishing you the best
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Marvel Assembles an Official Title for Third "Avengers" Movie
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With "Independence Day: Resurgence" making the world dangerous for Earthlings again, CBR looks at the best aliens attack films ever made.
The filmmaker is in talks to helm the Lionsgate adaptation, renewing questions about his involvement with Foxâs âGambit.â
Doug Liman is set to direct the follow-up to the 2014 sleeper hit, which will be penned by "Race" writers Joe Shrapnel and Anna Waterhouse.
With "Edge of Tomorrow" carrying the torch lit by "Groundhog Day," SPINOFF looks at films and TV shows where characters keep repeating their actions.
As "22 Jump Street" and "How to Train Your Dragon 2" battle for the top spot at the box office, the latest "X-Men" film becomes one of three 2014 films to pass $200 million domestically.
As âEdge of Tomorrowâ introduced audiences to its take on the mech suit, SPINOFF ONLINE looks back at some of the most memorable sci-fi movie weapons â from Death Stars to phasers.
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With the sci-fi thriller "Edge of Tomorrow" arriving today in theaters, SPINOFF looks back at some of Cruiseâs coolest action-hero moments.
The veteran actor talks with SPINOFF about starring opposite Tom Cruise in the sci-fi action film, and working with James Cameron on "True Lies" and "Aliens."
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The new home of
At the foot of the imposing Grampian mountains and just north of Perth, upon the banks of the River Ericht, is the town of Blairgowrie. As you would imagine from one of the largest towns in Perthshire, there is plenty to do and see here.
The countryside around Blairgowrie is hugely popular with walkers and cyclists and the countryside is simply breathtaking, with many way marked walks and cycle tracks for you to explore as you take in the areas natural, untouched beauty.
Dotted around the area are the reminders of the ancestral homes of the ancient clans, including Craighall Castle, home to the Clan Rattray, overlooking a gorge, and nearby Newton Castle, home to Clan Macpherson and finally Ardblair Castle, with connections to clan Oliphant. Newton Castle and Ardblair Castle are steeped in Jacobean history and intrigue and legend says that they are connected by a secret tunnel!
There are plenty of activities to keep you busy in Blairgowrie, from enjoying a spot of golf at one of the three golf courses in the area, hitting the slops at the nearby Glenshee Ski Centre in the winter, or if you visit on the first Sunday in September, enjoying watching the Blairgowrie Highland Games.
For days out Perth is nearby or venture a little further to Dundee, stopping off at Glamis Castle and Scone Castle.
So whether you are looking for a holiday steeped in history, a peaceful getaway amongst unspoilt countryside, or an activity based holiday, Blairgowrie is ideal place; search for Blairgowrie holiday cottages.
13 reviews
Nestling on a wooded hillside in a wonderful south-facing position overlooking Birnam Hill and Dunkeld Cathedral, this stylish, bright and spacious detached single-storey property is the ideal holiday base to explore the historic town of Dunkeld – only a 10-minute walk – and its selection of shops, pubs and restaurants. In the immediate vicinity are beautiful walks along the River Tay, a network of well-marked forestry paths and cycle routes. Also nearby is the Loch of Lowes Wildlife Centre. Fishing, golf and tennis are available locally, as well as a wide range of other sporting and adventure activities. Further afield are the mountains and lochs of highland Perthshire and a wealth of castles and historic sites. Also within easy reach are Edinburgh, Pitlochry, with its festival theatre, Perth, Dundee, St Andrews and the Fife coast. Shop 1/2 mile.
Entrance hall. Large comfortable open-plan living/dining room, farmhouse-style kitchen with French doors to decking with garden furniture and lovely views. Double bedroom. Bathroom with over-bath shower and toilet.
11 reviews
Set on a Highland estate spanning 4500 acres with hills rising to 2500ft, these four holiday properties are situated on the edge of the Cairngorms National Park with a wild flower reserve nearby, and an abundance of wildlife including ospreys and huge herds of deer. For 300 years Cistercian Monks spent half of each year at this peaceful place, making butter and cheese and brewing beer from the pure springs that continue to feed the houses. Delightful 18th-century Clover Cottage is reached from its parking area via a short track across a stream. With its own large garden with views towards the great massif of the Grampians. Claypotts is a charming 18th-century cottage, is in an utterly peaceful glen at the heart of the estate with its own enclosed garden on the banks of the River Isla. Croft End Cottage, a 15th-century cottage lies secluded behind double hedges and is a romantic yet fabulously comfortable place perfect for explorers, lovers and honeymooners. Brewlands Cottage is a 17th-century, cosy, very comfortable property in a lovely riverside location with fishing from the garden and views of high hills and surrounding quiet countryside. There are ancient wild flower meadows with rare wild yellow violets and orchids. Red squirrels live around the gardens and the walls support rare ferns and lichens which grow only in unpolluted places. Walking from the door of each cottage. Excellent golf courses at St Andrews, Carnoustie, Gleneagles and Rosemount. Glenshee ski resort is 35 minutes, as is Pitlochry with its theatre, restaurants and kilt and cashmere shops. An adventure centre 20 minutes away, with pony trekking at Balmoral Estate and many castles and stately homes to visit: Balmoral, Glamis, Blair Atholl, Scone Palace and Braemar. Visit the famous Whisky Trail. Riding centre 6 miles. The oldest tree in Europe is in Fortingall, 1 hour. Shops 12 miles, pub 2 miles.
Spacious beamed living/dining room with cast-iron wood-burning stove. Well-equipped, modern farmhouse-style kitchen. Bathroom with over-bath shower and toilet. Open-tread, spiral stairs to first floor: Galleried double bedroom with 5ft bed and beams overlooking living room.
10 reviews
These three properties are situated in a peaceful wooded area with walks right from the doorstep and numerous roe deer around, yet only 2½ miles from the village of Dunkeld with its shops, ancient fountain and cathedral. Osprey Cottage (ref 15885) has been converted to create a super holiday retreat with rugs on polished wooden floors upstairs in the living areas, and cosy bedrooms below. Heather Croft (ref 26213) is a detached bungalow nearby, cleverly designed by the owners with lots of windows to maximize views of the surrounding countryside. The But 'n' Ben (ref 28139) is a charming converted barn for two. An ideal choice whatever the weather. Next door to Dunkeld is Birnam, home of the Beatrix Potter exhibition and where there are riverside walks along the Tay. An 18-hole golf course is 1½ miles away beside the Loch of Lowes Wildlife Reserve. There are walks and cycle tracks in the bordering forest. Fishing locally. Shops and pubs 2½ miles.
All on ground floor: Living/dining room/kitchen with patio doors and tiled floor. 1 double bedroom with en-suite shower room and toilet.
Oil central heating included (£25per week 15th September-21st April). Gas and electricity included. Travel cot and high chair (on request). Freeview TV. DVD. CD. Gas hob. Electric oven. Microwave. Shared laundry room with washing machine. Fridge/freezer. Wi-Fi. Parking (1 car).
All properties: Bed linen and towels included. Dishwasher. Shared 3-acre natural and wooded grounds with sitting-out area and furniture. Cycle store. No smoking. NB: Unfenced stream in grounds.
0 reviews
Ground Floor: 2 steps to entrance. All on the ground floor.Living room: With open fire, 18" Freesat TV and CD player.Step up to...Kitchen/dining room: With electric oven, electric hob, microwave, fridge, freezer, coffee machine, washing machine and tumble dryer.Bedroom: With twin beds.Step down to...Bathroom: With shower over bath, toilet and heated towel rail.Separate toilet.
Electric storage heaters, electricity, bed linen, towels, Wi-Fi and logs for open fire included. Travel cot and highchair available on request.Sitting-out area with garden furniture. Shared use of natural woodland grounds. Parking for 2 cars. No smoking. Please note: The property has a natural spring water supply from a well and there are sloping banks in the grounds.
1 reviews
First Floor: The property is all on the first floor, has gas central heating and comprises:Lounge/dining room: With electric wood burner, 32" Sky TV (full package), DVD player and iPod dock.Kitchen: With electric cooker, microwave/oven/grill, fridge, freezer, washing machine and sloping ceilings.Bedroom 1: With double bed.Shower room: With shower and WC.
All gas, electric, bed linen and towels included. Wi-Fi. Large enclosed shared garden with sitting-out area and furniture. Parking (1 car). Cycle store. Natural water supply from a well. No smoking. NB: Fenced stream in garden.
2 reviews
Ground Floor: Open plan living space.Living area: With open fire, 18" Freeview TV, DVD player and CD player.Dining area.Kitchen area: With electric oven, electric hob, microwave, fridge, washing machine and tumble dryer.Bedroom: With kingsize bed.Shower room: With shower cubicle, toilet and heated towel rail.
Electric storage heaters, electricity, bed linen, towels and logs for open fire included. Cot and highchair. Garden with garden furniture. Shared use of natural woodland grounds. Paddocks available for horses (at cost). Parking. No smoking. Please note: The property has a natural spring water supply from a well and there are sloping banks in the grounds.
17 reviews
Ground Floor: Open plan living space Living room: With gas 'log effect' stove fire (remote controlled), TV, DVD and ipod/CD/digital radio. Dining Area Kitchen: With electric oven, electric hob, microwave, fridge (without icebox) and dishwasher Utility Room: With washer/dryer, freezer Shower Room: With shower cubicle, toilet and heated towel rail.
First Floor: Bedroom: With king sized bed, TV and coombed ceiling Bathroom: With bath, toilet, heated towel rail and coombed ceiling
Electricity, solar hot water system, bed linen, towels and Wi-Fi included. Travel cot, high chair and stair gate available by request. Private, secluded decking to the rear of the property with sunken HOT TUB (note care must be taken around the decking and hot tub as it can be slippery and children should not be left unattended). Outdoor furniture and views onto farm fields. Secure storage for bikes available. A day bed (suitable for a child only) is available by request for optional sleeping arrangements and would be located on the upstairs landing. Off road parking for 2 cars on shared driveway.
20 reviews
Set on a working arable and cattle farm, within the owner's 2000-acre estate in the Vale of Strathmore, these three welcoming and spacious holiday properties have been restored to a very good standard. Islabank Farmhouse (ref SAAP) is a traditional, characterful, comfortable farmhouse which is ideal for families, Curlew Cottage (ref SYYJ) is a charming, beautifully converted, detached, single-storey property and Osprey Cottage (ref UZQ) is a delightful, light and sunny, single-storey detached cottage. Set amongst beautiful farmland and fruit-growing country, they make an excellent choice for relaxing breaks in the heart of rural Perthshire. The estate makes an ideal base for exploring central Scotland, Edinburgh, Perth, St. Andrews and the Highlands. Glamis Castle is a few miles away. Outdoor activities (golf, skiing, riding, cycling) are readily available. Shops and pub 3 miles.
Living room with wood-burning stove and wooden floor. Well-equipped, country-style kitchen with wooden floor, open-plan with dining area, floor to ceiling windows with French door to patio and views of garden and woodland. Utility. Double bedroom with 5ft bed, TV and en-suite bathroom with roll-top slipper bath, separate shower cubicle, toilet and tiled floor. Separate toilet.
Note: Islabank Farmhouse SAAP, Curlew Cottage SYYJ and Osprey Cottage UZQ and can be booked together to sleep up to 12 people.
Ground Floor: All on the ground floor.Living room: With open fire, 18" Freeview TV, DVD player and CD player.Kitchen/dining area: With electric oven, electric hob, microwave, fridge, dishwasher, washing machine and tumble dryer.Bedroom: With kingsize bed and single bed.Bathroom: With bath, shower cubicle, toilet and heated towel rail.
Electric storage heaters, electricity, bed linen, towels and logs for open fire included. Cot and highchair. Garden with sitting-out area and garden furniture. Shared use of natural woodland grounds. Paddocks available for horses (at cost). Parking. No smoking. Please note: The property has steps to the garden and a natural spring water supply from a well and there are sloping banks in the grounds.
13 reviews
This lovely, semi-detached holiday property is in a peaceful, rural setting, overlooking the Sidlaw Hills in the Vale of Strathmore. Explore walking in the beautiful Angus Glens or play golf locally at Alyth and Rosemount or St Andrews, Carnoustie and Gleneagles, all well within an hour's drive. Cycling, fishing and tennis nearby. Glenshee ski resort is about 25 miles and Glamis Castle, Scone Palace, Edinburgh, Perth and the Highlands are within easy driving distance. Shops and pubs 1½ miles.
Ground floor: Living room. Dining room/kitchen. Conservatory. Separate toilet. First floor: 2 bedrooms: 1 double (5ft) with en-suite bathroom with shower attachment and toilet, 1 twin with en-suite bathroom with bath, shower cubicle, toilet and Velux.
Open fire in living room included. Oil central heating and electricity included (£25per week November-March). Bed linen and towels included. Cot. High chair. DVD. CD. Electric cooker. Microwave. Washing machine. Dishwasher. Use of owner's freezer. Enclosed lawned garden and furniture. Parking (3 cars). No smoking.
12 reviews
Peaceful residential area
This attractive spacious detached bungalow is situated in a quiet elevated cul-de-sac in a peaceful residential area of Blairgowrie. The rear of the holiday home backs onto an enclosed garden and sitting-out area, accessed from a very large pleasant sun room, enjoying a high degree of privacy. Blairgowrie is a market town in the heart of Perthshire, with plenty of shops and restaurants. Excellent walking, riding and cycling in the nearby Glen Isla and Glen Shee, as well as skiing in winter. Golf locally at Alyth and Rosemount. Organised events locally include Highland Games as well as good theatres at Perth, Dundee and Pitlochry. Shop, pub and restaurant 0.5 miles.
All on ground floor: Living room. Dining room. Kitchen. Sun room with patio doors. Utility room. 2 bedrooms: 1 double, 1 twin with en-suite shower room with walk-in shower and toilet. Bathroom with shower over Jacuzzi bath, bidet and toilet.
Electricity, bed linen and towels included. Video and small library. DVD and small library. Stereo/CD. Electric cooker. Microwave. Washer/dryer. Dishwasher. Freezer. Wi-fi. Enclosed lawned garden with furniture. Parking (2 cars).
119 The Glade is part of the beautiful Erigmore Estate by the River Tay, and offers self-catering holiday accommodation along with superb facilities such as a restaurant and bar, swimming pool and children's play area. This detached lodge is immaculately presented and provides spacious, contemporary accommodation, which is ideal for relaxing in and enjoying the area with friends and family. The kitchen is fitted with an integrated dishwasher, double oven and combination microwave, making eating in a pleasure, while there are flat-screen televisions in every room, along with a blu-ray player, DVD player and surround sound system in the living room, meaning entertainment is just a flick of the remote away. The decking area is ideal for al-fresco dining or just relaxing on, while the barbecue is ready and waiting for those warm summer evenings. Quite literally a stone's throw away, the glorious River Tay offers relaxing walks in all seasons. The pretty Victorian village of Birnam has shops, restaurants and coffee shops, and there is also a bar and restaurant on site. The Birnam Institute has a remarkable programme of music, drama and other events all year round. For those with energy to burn, there are adventure activities galore, mountain and road biking, and challenging walks, whilst nature lovers are spoilt for choice. Shop 1 mile, pub and restaurant 300 yards.
3 steps to entrance. All on ground floor: Living/dining room with patio doors/kitchen with breakfast area. Utility room. 2 bedrooms: 1 double (5ft) with en-suite bathroom with shower over bath and toilet, 1 twin with en-suite shower room and toilet (also accessed from hall).
Electric coal-effect fire in living room. Gas central heating, gas, electricity and bed linen included. Travel cot and high chair on request. Three Freeview TVs (one 32"). DVD. Blu-ray. iPod dock. Gas hob. Electric oven. Combi microwave/oven/grill. Shared laundry room with coin-operated washing machine and tumble dryer. Dishwasher. Freezer. Wi-fi. Decked sitting-out area and furniture. Shared landscaped grounds. Barbecue. Parking (3 cars). Shared, indoor heated swimming pool (24m x 12m, depth 1m to 1.6m) with Jacuzzi, shower and changing facilities, open 9am to 1pm and 2pm to 5pm. Shared games room with pool table. Shared sports area. Shared children's play area. No smoking. NB: Path leading to River Tay. Sloping banks in grounds.
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Yeah he did that! Apparently President Obama looked all over the White House for some chill but came up empty as there was zero chill in his pockets when he walked up to the podium at the 2014 White House Correspondence Dinner and we loved every last minute of it!
It's nice to see the President get a moment to dish out a little bit of what he has to take off of everyone in that room all year long. Out of 365 days in a year, President Obama is usually being trashed somewhere on 364 of them!
But then there is that one day…that he gets to give folks a taste of their own medicine and they just have to take it! See what that day looks like in the video below!
Told ya! Zero chill! Thanks for the laugh sir!
The World Reacts to President Obama's Win
The World Reacts to President Obama's Win
1. 1. People in El Pais, Spain celebrated the victory of President Obama. (AP)1 of 25
2. 2. Muslim students pose shortly after voting in the mock US election held in the Philippines.2 of 25
3. 3. Indian students react to results on TV during an event organized by the U.S. embassy in New Delhi, India.3 of 25
4. 4. A moment later, the Indian students erupt into cheers for the re-election of President Obama.4 of 25
5. 5. A sand sculpture on the beach in Puri, India is created offering congratulations to the President.5 of 25
6. 6. Sarah Obama, step-grandmother of President Obama, waves her walking cane in celebration. (AP)6 of 25
7. 7. Students from the school where Obama studied in Jakarta, Indonesia hold up a poster of him. (AP)7 of 25
8. 8. An American supporter of President Barack Obama holds a flag and sports a T-shirt in Bangalore, India. (AP)8 of 25
9. 9. U.S citizens celebrate U.S. presidential election results in Mumbai, India. (AP)9 of 25
10. 10. A Kenyan supporter of President Barack Obama cheers as he watches a broadcast showing that Obama has won. (AP)10 of 25
11. 11. A U.S. citizen reacts as he watches the live telecast of presidential election results in Mumbai, India. (AP)11 of 25
12. 12. Villagers celebrate in the village of Kogelo, home to Sarah Obama the step-grandmother of the President. (AP)12 of 25
13. 13. U.S. embassy staff, Iraqi guests & ambassadors listen to the speech of President in Baghdad. (AP)13 of 25
14. 14. President Obama supporters in Turkey cheer after hearing the results that he has been re-elected.14 of 25
15. 15. Indian Muslim students pose for photographs near cutout of President Obama. (AP)15 of 25
16. 16. President Obama supporters celebrate upon hearing the presidential election results in Singapore.16 of 25
17. 17. Italian Democrats celebrate President Obama's win in Rome. (AP)17 of 25
18. 18. U.S. citizens break into a dance as President Barack Obama's win becomes certain in New Delhi, India.18 of 25
19. 19. Indian students have their picture taken a President Obama cardboard cutout in New Delhi.19 of 25
20. 20. A Muslim woman poses for a photo with a cutout of President Obama celebrating his win in Jakarta, Indonisia.20 of 25
21. 21. President Obama supporters react upon hearing the presidential election results in Holland. (AP)21 of 25
22. 22. President Obama supporters react upon hearing the presidential election results in Japan. (AP)22 of 25
23. 23. Supporters in Chicago react to the election results for President Barack Obama. (AP)23 of 25
24. 24. Arizona Democrats celebrate as President Obama is declared the winner of the presidential race.24 of 25
25. 25. Supporters wave flags during President Barack Obama's election night party in Chicago. (AP)25 of 25
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LA Clippers Owner Donald Sterling Gives Statement And Denies Being Racist: World Reacts
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While secrecy in communication systems has historically been obtained through cryptographic means in the upper layers, recent research efforts have focused on the physical layer and have unveiled ample opportunities for security design. In particular, the combination of signal processing techniques with channel coding for secrecy has been central to the development of physical-layer security efforts. Although implicit coding techniques for secrecy have been known since the 1970s, explicit code constructions have only been discovered within the last decade. The purpose of this article is to provide a synopsis of the state of the art in coding for secrecy. We discuss the general principles of coding, and we illustrate them with several examples. In particular, we discuss the importance of a nested code structure and stochastic encoding, which allow for both data reliability and security.
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Shannon Tweed
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Shannon L Tweed (Age: 39)
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High quality Shannon Tweed pictures and hot pictures, Shannon Tweed news, biography, contact information and much more.
Shannon Tweed May Not Be Accepting Gene Simmons' Proposal | Reality...
Shannon Tweed May Not Be Accepting Gene Simmons' Proposal Despite what Shannon Tweed says was the most shocking moment of her, the star reveals that she and...
Celebrity Birthdays March 10: Carrie Underwood, Olivia Wilde, Sh...
…e out this year – "Welcome to People", "Blackbird" and "The Longest Week". Happy Birthday, Shannon Tweed! The blonde beauty is 55 years old today. I'm a big "Days of Our Lives" fan and reme…
KISSopolis: Gene Simmons & Shannon Tweed In Cannes
20.05.2012 Here's a photo Gene Simmons posted on his Twitter account of him and Shannon in Cannes, France this week. Gene writes: "Here we are on a nice, sunny day in Cannes, France. Yes, I'm holding a nice, fashionable handbag ...
Gene Simmons Marries Shannon Tweed | ExtraTV.com
02.10.2011 After 28 years together, rocker Gene Simmons, 62, and Shannon Tweed, 54, finally said "I do" on Saturday at the Beverly Hills Hotel.
Lifechangers: Shannon Tweed on Hyperhidrosis | ExtraTV.com
09.12.2010 Shannon Tweed is the longtime partner of Kiss star Gene Simmons, and she talked to "Extra" about suffering from hyperhidrosis, and what she did to get help for her condition. Hyperhidrosis is excessive sweating in certain ...
Shannon Tweed's Twitter Tweets on CelebrityTweet! Stalk Shannon Tweed...
Home > Shannon Tweed. Currently appearing in A&E's Gene Simmons Family Jewels, happily unmarried to KISS bassist Gene Simmons for 26 yrs.
'Get a sense of humor'! Actress Shannon Tweed slams busybodies losing...
Actress Shannon Tweed slams busybodies losing it over Sofia Vergara sketch. Posted at 4:03 pm on August 26, 2014 by Twitchy Staff | View Comments.
Shannon Tweed - Celebrities at Weblo.com
Shannon Tweed in Weblo virtual world has ranking of 5.04 and earning of $13.9799999999999. Become virtual editor for your favorite celebrity for free right now...
Entertainment City: Shannon Tweed talks 'Seed' - CityNews
On the national edition of Entertainment City, controversy follows Justin Bieber to Japan, plus Shannon Tweed talks 'Seed.'
Gene Simmons And Shannon Tweed | GRAMMY.com
"Nobody messes with my lady in blue." Gene Simmons and a sparkly Shannon Tweed attend the People's Choice Awards 2012 on Jan. 11 in Los Angeles.
Shannon Tweed - El cine en 20minutos.es
Shannon Tweed - El cine en 20minutos.es
Shannon Tweed
Shannon Tweed: Filmek, képek, fórumok, információk, érdekességek erről a színészről: Shannon Tweed.
Shannon Tweed Archives - Macleans.ca
The 31st annual Genie Awards were held at Ottawa's National Arts Centre. Below, Industry Minister Tony Clement. . Laureen Harper. . Shannon Tweed and the ...
Shannon Tweed Tickets | Event Dates & Schedule | Ticketmaster CA
Buy Shannon Tweed tickets from the official Ticketmaster CA site. Find Shannon Tweed Comedy schedule, reviews and photos.
Shannon Tweed Tickets | Event Dates & Schedule | Ticketmaster.com
Buy Shannon Tweed tickets from the official Ticketmaster.com site. Find Shannon Tweed schedule, reviews and photos.
Shannon Tweed Tickets | Comedy Show Times & Details | Ticketmaster IE
Buy tickets for Shannon Tweed from the Official Ticketmaster IE site. Find reviews and event dates for Comedy events.
Shannon Tweed Tickets | London & UK Comedy | Show Times & Details
Buy tickets for Shannon Tweed from the Official Ticketmaster UK site. Find reviews and event dates for Comedy events.
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This hotel is conveniently located off I-77 and all LaQuinta properties are pet friendly which is why we chose it. The room we had was OK, but the bathroom was very tired looking - cracked floor tiles and a large crack in the sink. The tub did not have a flat bottom - this sounds odd, but if someone had mobility issues they would have a hard time standing while showering - never saw this before. The bed was comfortable and the room "appeared" clean, but my dog could sense that other dogs had "used" the room. Very quiet - good soundproofing, despite being on the first floor. Would not stay here if I didn't have a dog. Other chain hotels provide better human amenities for the same price. On the plus side, La Quinta does not charge for your pet as other chains do. The staff was pleasant and helpful at check-in and the breakfast is comparable to other chains but not served until 7 on Sundays.
This was my second stay at a LaQuinta property and both times I've been underwhelmed. The ranking of #24 out of 166 hotels is Charlotte has me wondering what the other 142 hotels are like.
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- La Quinta Charlotte
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Comment – May 6, 2015
This company is great at making promises, but horrible at following through. Very 'flavor of the month'. While they put on a great show, there is little actual direction and communication. I would suggest against anyone leaving their current job to pursue a career here.


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The Earth Teaberry is a casual women's slip-on shoe with wedge heel and suede bow accent.
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I can go all day in these shoes- even with swelling feet and plantar fascitis. They never quit and the look great.
Nice fit, but the color was darker than the picture. Well-made shoes, tho, comfortable!
My absolute favorite shoes. I had them in black and wore through them. Now I have them in blackberry. Great everyday all day shoes. The wide size is more comfortable for me.
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"My first delivery an incorrect item. If I had placed my order by phone rather than online I feel sure the confusion of ordering the correct item would not have happened. When I called your customer service line your representative was very knowledgeable about your products. She determined what the correct replacement should be and expedited my shipment and I received it in time for my trip. My experience with your company was a pleasant reminder that excellent customer service still exists."
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Fixed PriceBudget: $15
Start DateJanuary 18, 2013
I am looking for a skilled graphic designer to complete t-shirt mock ups for my company. It is approximately 20-25 mock up designs I will need done. I will provide you with a word document that outlines which of my company logos on which shirts. I will also send you the logo files and the specific t-shirt mock ups that I need the logo put on.
I need to hire someone who can turn this job around within the next day (next two days at the latest). So please only apply for this job if you are readily available and can produce good, high quality work. I will need the files in png format so I can display them in my online store and also use them for advertisments.
About the Client
United States
Richmond 11:40 AM
Jobs Posted
65% Hire Rate, 1 Open Job
Total Spent
102 Hires, 0 Active
Avg Hourly Rate Paid
92 Hours


text: 7. Equinix ( EQIX) offers businesses the expertise to connect with partners and customers around the world through a global platform of high performance data centers, containing dynamic ecosystems and the broadest choice of networks. Equinix operates in 38 strategic markets across the Americas, EMEA and Asia-Pacific and continually invests in expanding its platform to power customer growth. Of the 25 analysts covering the stock, 72% recommend a buy and 24% rate a hold. Analysts have average 12-month price target of $119.06 for the stock, about 18% higher than the current price, according to a Bloomberg consensus. Quarterly net revenue was up 26% year-over-year in the third quarter. Revenue grew to $417.6 million from $330.3 million in the same quarter prior year. Net income increased to $20.3 million, or 20 cents, up 83% from the prior year. Total revenue outlook for fiscal 2011 is expected greater than $1.6 billion. Adjusted EBITDA for the year is seen to be over $730 million. Capital expenditure for 2011 is projected between $645 million and $665 million, comprising of approximately $115 million of ongoing capital expenditure and $530 to $550 million for expansion capital expenditure. Total revenue guidance for full year 2012 is projected to top $1.9 billion. Adjusted EBITDA is expected to be greater than $850 million. Capital expenditure for 2012 is seen ranging from $700 million to $800 million, comprising of approximately $120 million of ongoing capital expenditure and $580 to $680 million for expansion capital expenditures. In Nov. 2011, EQIX opened the first phase of its second International Business Exchange data center called HK2, primarily to meet the growing demand for premium collocation and interconnection data center services, principally from financial services organizations and cloud service providers operating in the city of Hong Kong. Prev 3 of 10 Next


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Los Angeles
LA-Based Coding Bootcamp Codesmith Boasts 96% Hiring Rate
By Conor Cawley | Jul 27, 2016 at 5:00 pm
Finding a job can be hard. But in this economy, finding a job with a hearty paycheck is even harder. Fortunately, study after study has shown that IT professionals and computer science graduates are going home with the biggest paychecks on a regular basis. But…
Remote work
How to Build a Strong Remote Team, According to 10 Entrepreneurs
By Conor Cawley | Jul 27, 2016 at 4:42 pm
This article is sponsored by Vast Conference, which offers an award-winning, instant conference calling service. As technology advances and the need for quality employees grows, more and more companies learn to adapt to the remote working model. After all, what's the point in having…
Product Launch
Tumblr Adds YouTube-Style Revenue Sharing for Its Bloggers
By Adam Rowe | Jul 27, 2016 at 4:00 pm
Tumblr made a quiet announcement yesterday: They're allowing users to make money off of ads that will be added to their blogs. The micro-blogging site will start the process by introducing ads on all blogs, with an opt-out button available in the settings, beginning tomorrow….
Product Launch
How Reddit's Latest Advertising Plan Will Push the Platform Forward
By Cameron Glover | Jul 27, 2016 at 3:33 pm
When it comes to finding the best way to make online platforms profitable, many companies are still figuring out a magic formula. But with digital media reshaping how we're able to use these tools to improve how we create content for consumers and ensure…
Healthy Entrepreneur
Study: Being Depressed Can Make You More Creative
By Conor Cawley | Jul 27, 2016 at 3:00 pm
For years, artists and entrepreneurs have accepted the notion that sadness breeds creativity. The idea is as old as time, as thousands of the world's most creative minds often suffer from personal tragedy and unmitigated melancholy. From Ernest Hemingway to Robin Williams to Roy Raymond, successful artists…
Tips & How To's
The 5 Most Common Mistakes Startups Make While Prototyping
By Adam Rowe | Jul 27, 2016 at 2:30 pm
San Francisco-based design and development studio Yeti just released a white paper detailing the ins and outs of prototyping, an essential early step in any developer or designer's process. Lean startups should take note, as they'll need to stay on top of the best practices in order to reach…
Edtech Startup EverFi Receives $40 Million Investment
By Conor Cawley | Jul 27, 2016 at 2:02 pm
Education is not always valued in the business world. Because there are so few direct avenues to profit, investors have typically strayed away from the questionable sector. But with the advent of edtech startups and the obvious need for better schooling in this country,…
Gear & Gadgets
STYR Labs Launches Fitness Gadgets That Tell You What Supplements To Take
By Elliot Volkman | Jul 27, 2016 at 1:22 pm
The Internet of Things is only just beginning, turning everything in our lives into a connected device. One particular industry that has done well by it, as well as some flops, is the health and wellness space. From wearables to smart clothing, even connected…
Pokémon Go Takes Players to Some Weird Places [Infographic]
By Sara McGuire | Jul 27, 2016 at 12:15 pm
Since the release of Pokémon Go, fans have embraced the Pokémon trainer calling in droves. Sure, sometimes they walk into street lights by accident because they're looking down at their phones, or they end up turning around in circles like spinning tops, but that…
Case Study
In Today's Job Market, Only 16 Percent See Workplace Change
By Cameron Glover | Jul 27, 2016 at 11:34 am
Though there have been many strides to combat it, the job market has mostly failed to meet the demand to match qualified candidates with job roles that have both "good pay and healthy wage gains". Today, it seems like job seekers have a variety…
Tips & How To's
The One Essential Tip That Late-Career Entrepreneurs Need
By Adam Rowe | Jul 27, 2016 at 11:00 am
The average successful startup founder is about 40, and they're all working with different strengths and weaknesses than the younger crowd. They have a lot more knowledge about their industry, for instance, but they can't pull nearly as many all-nighters to put together their business….
How Does 'Full Stack' Translate in the Job Market?
By Cameron Glover | Jul 27, 2016 at 10:17 am
For those on the job market, it's paramount that they embody as many hire-able skills and experiences as possible. But with the market getting more competitive and employees looking to transition roles across various industries, it can be difficult to find definite skills to…
What Popular and Profitable Mobile Games Have in Common
By Dianna Labrien | Jul 27, 2016 at 9:45 am
Mobile games are still the most popular category in the App Store and account for 23.35 percent of all downloads. Considering the recent Pokémon Go craze going around, you might have thought about building a cool gaming app of your own. But here's a kicker…
Survey Says: 80% of SaaS Professionals Are Clueless
By Adam Rowe | Jul 27, 2016 at 9:12 am
SaaS, short for "software as a service," is a business model that depends on selling subscriptions to a proprietary software, usually to businesses. Retaining clients is just as important to the bottom line as adding them in the first place. That's why the results of…


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The 26-year-old suffered a dislocated shoulder earlier this month but looked set for a January return to action before his shoulder popped out again, meaning he will have to go under the knife.
Manager Chris Wilder, who celebrated four years in charge of the U's on Friday, will also be without Adam Chapman, who fell awkwardly and injured his ankle in Tuesday's 2-0 FA Cup victory over Accrington.
Meanwhile, experienced defender Michael Duberry came through his late return to action against Accrington unscathed having not played since May.
But Simon Heslop is unavailable again as he serves the last game of his three-match ban.
Oxford are 18th in League Two ahead of their first-ever meeting with The Cod Army, eight points below the play-off places and eight above the relegation zone.
- Sports & Recreation
- Adam Chapman
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Electrical problem
1999 Acura CL 6 cyl Automatic 145710 miles
I just brougt a used 99 Acura CL from NY dealership.I drove it home and noticed the speedometer no longer works and the Odometer has not even moved. The car is out of state and will not pass inspection so what can I do?
Tuesday, September 8th, 2009 AT 9:12 PM


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Historical Downtown Apartment
Size20 m²
Floor No.4
- Internet/WiFi
- Towels
- Kitchen
|Via delle Pinzochere, 50122 Firenze, Italy
|Property type
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
|3 days ago
Very quiet and comfortable, decorated in classic style, with a wonderful view on the typical Florence roofs (you can even see the Dome not so far from the bedroom window). Ideas for a romantic holiday in Florence (max 2 guests - bed size 120x195 cm) or for a lonely long stay for writers and teachers (max 1 month - no washing machine and no oven).
If you are looking for a perfect place in Florence you can choose the classy Brick Decimo. You will love the area, really central and close to Sant' Ambrogio district (really typical and characteristic). On your arrival at home you will find a welcome letter filled with useful advices and a map of the area, plus fresh fruits and a bottle of red Chianti wine!
Do not miss the opportunity to be in the heart of the city, near the main attractions, with all the comforts you need! At the Brick Decimo Apartment you will feel like a Florentine in his home town!
|Weekly rate
|Monthly rate
|Check-in after
|Check-in before
|On arrangement
|Check-out before
|Cancellation Policy
The appartment is very nice and well located, as it says in the description. Maddalena is really a lovely person and a very caring host. In our stay one of our computers got broken and she could get one for us (really saved us as we needed it for our work). She was also very flexible with the check-out. If I ever come back to Florence I will definetly stay at this appartment again. Highly recommended!
Very nice welcome, nice appartment decorated with taste! Perfectly located near centre. All you need for a short trip to Florence!
Das Appartment ist sauber und sehr geschmackvoll eingerichtet, die Lage sehr gut, weil Alles gut zu Fuß erreichbar ist.
Die Gastgeberin ist bemerkenswert freundlich und hilfsbereit.
Jederzeit wieder.
Appartamento piccolino, ma perfetto per due persone, fornito assolutamente di tutto il necessario. Posizione perfetta per muoversi agilmente e visitare la meravigliosa Firenze, anche con soli 3 giorni a disposizione! Maddalena è stata gentilissima dall'inizio alla fine del soggiorno! Consigliato!
Accueillante et gentille, Maddalena nous a permis de passer un très bon séjour. L'appartement était idéalement situé, en plein centre de Florence. Nous avons apprécié les quelques fruits et recommandations sur la ville laissés par Maddalena à notre arrivée. L'appartement était propre, agréable à vivre et très charmant.
Nous recommandons !
Grazie Maddalena!
L'appartamentino è davvero molto grazioso e ben fornito, La posizione dietro la bellissima chiesa di Santa Croce direi che è un lusso! Maddalena è stata gentilissima nel darci indicazioni e consigli.
Unica pecca, la tv non funzionava, ma in cambio abbiamo ascoltato la radio ;)
Un ottimo modo per godersi Firenze e sentirsi come a casa :)
We had a great time in the apartment. It looks exactly as shown in the internet.
It is a great place to stay in the centre of Florence, everything is near to it.
There's a nice terrace with an amazing view !!!
Maddalena is very kind, answers all the time and helps you with everything!
I think it is one of the best places to stay in Firenze!!
Maddalena has a great apartment, beautifully decorated and on a perfect spot in the middle of Firenze. Everything you want to see or visit is in walking distance. Maddalena is a great and helpfull host. She and her boyfriend helped us with getting a cab to the AirPort. We recommand the Captain Appartment and Maddalena to everybody.
I had a wonderful month in Florence and Maddalena was the perfect host. She is helpful, generous and friendly and I would definitely come back to the Fancy Apartment. It's in the ideal position, very close to the main attractions yet so peaceful.
I was living in this apartment about 3 months for studying in a school in the center of Florence. I was very happy to stay there because this apartment is situated in very comfortable place, only 10 min to walk at Duomo San Maria del Fiori. It's a really beautiful historical center of Florence, very comfortable for sightseeing. Near of the flat there are shops, supermarket, daily market, farmacy's, restorants etc. The apartment is lightful, very cosy and has everything you need. Wifi works perfect! The apartment manager Maddalena is very friendly, helpful and caring. She is always in touch and take care of her guests! I was really lucky to stay there and met Maddalena. Everything was perfect! Thank you Maddalena!
- Quality assured accommodation
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Justice and the Media: Reconciling Fair Trials and a Free Pressby Matthew D. Bunker
View All Available Formats & Editions
Pub. Date: 06/01/1997
Publisher: Taylor & Francis
USE THIS FIRST PARAGRAPH ONLY FOR GENERAL CATALOGS... The First Amendment right of free speech is a fragile one. Its fragility is found no less in legal opinions than in other, less specialized forms of public discourse. Both its fragility and its sometimes surprising resiliency are reflected in this book. It provides an examination of how the U.S. Supreme Court has dealt with the problem of restrictions on media coverage of the criminal justice system, as well as how lower courts have interpreted the law created by the Supreme Court. The author explores the degree to which the Court has created a coherent body of law that protects free expression values while permitting reasonable government regulation, and examines the Supreme Court's jurisprudence concerning prior restraints, post-publication sanctions on the press, and their right of access to criminal proceedings.
This is a study of the evolution of constitutional doctrine -- particularly when transported from the rarefied air of the Supreme Court to lower court judges who may not share the values of the jurists above them in the judicial hierarchy. The book's greatest strength lies in its thorough analysis and critique of how judges apply First Amendment doctrine to the complex problem of providing for both a "free press" and "fair trials." Much of the available literature on this topic focuses on legal doctrine, but with attention to the legal rules that emerge from the courts, rather than examining and critiquing the judicial techniques that produce those rules. Moreover, although a significant body of scholarship has explored Supreme Court doctrine, this work is one of the few that trace the influence of those doctrines through lower federal court decisions. The hope is to produce a reasonably accurate -- if partial -- picture of how intermediate appellate and trial courts use U.S. Supreme Court doctrine to decide First Amendment cases.
Note: This book is necessarily influenced by the 'round-the-clock' press coverage of the recent O.J. Simpson trial. Although the Simpson case did not make new law, the trial and its outcome seem to be -- at this writing -- an inescapable part of how many people think about these issues. The simple truth, however, is that the Simpson case was an anomaly that has little relation to the everyday concerns of media coverage of the criminal justice system. While the venerable "parade of horribles" can be an effective strategy for the legal advocate, it is not always the ideal way to address larger concerns, particularly when fundamental rights are at stake.
Product Details
- 9780805821680
- Publisher:
- Taylor & Francis
- Publication date:
- 06/01/1997
- Series:
- Routledge Communication Series
- Edition description:
- New Edition
- Pages:
- 160
- Product dimensions:
- 6.20(w) x 9.28(h) x 0.64(d)
- Lexile:
- 1680L (what's this?)
Table of ContentsContents: Preface. Scrutinizing the Scrutiny Structure. The Supreme Court and First Amendment Scrutiny. Courts and Prejudicial Publicity. Prior Restraints. Postpublication Sanctions. Access to Proceedings. Defects in the System. A Proposal for a Categorical Solution.
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Braeger Chevy helped make these videos
We are still working to obtain content for your car, however the video above is believed to have similar characteristics as your car.
The video above shows how to replace blown fuses in the interior fuse box of your 2000 Oldsmobile Alero in addition to the fuse panel diagram location. Electrical components such as your map light, radio, heated seats, high beams, power windows all have fuses and if they suddenly stop working, chances are you have a fuse that has blown out. If your Alero is experiencing electrical problems, you should always check the fuses first, because they are relatively easy to check and cheap to change. Some Oldsmobiles have multiple interior fuse boxes including in the trunk - the video above will show you where the interior fuse box of your 2000 Alero is located. If your Alero has many options like a sunroof, navigation, heated seats, etc, the more fuses it has. Some components may have multiple fuses, so make sure you check all of the fuses that are linked to the component in question.
If you need to replace a blown fuse in your Alero, make sure you replace it with one that has the same amperage as the blown fuse. If checking and replacing the fuse for the component in question doesn't work, we recommend seeking assistance from a trusted professional mechanic. They should be able to figure out if the component needs to be replaced or if there is a short or some other problem with your Alero.
Coolant hoses wear out over time and need to be replaced - check 'em early and often2000 Oldsmobile Alero GL 3.4L V6 Sedan (4 Door)
Want an easy way to save $500? Rotate your tires at least three times per year2000 Oldsmobile Alero GL 3.4L V6 Sedan (4 Door)
A few key tips will make jacking up your car much safer2000 Oldsmobile Alero GL 3.4L V6 Sedan (4 Door)
Low coolant levels is all to common - top yours up today2000 Oldsmobile Alero GL 3.4L V6 Sedan (4 Door)
Learn where your spare tire and jack are located before you need it on the side of the road2000 Oldsmobile Alero GL 3.4L V6 Sedan (4 Door)
Don't send mixed signals - if your turn signal doesn't blink, or blinks rapidly, you likely have a burnt out bulb2000 Oldsmobile Alero GL 3.4L V6 Sedan (4 Door)


text: M.T. was born in Lockhart, TX on March 22, 1959. His parents were nomads, traveling around Texas looking for work in cotton fields and picking pecans for gas money (often living in abandoned houses, broken down barns, sometimes just sleeping in their Plymouth station wagon). It was during the summer of 1966 that M.T.'s father found a job working for a turkey ranch when the family could finally settle into an actual home in Austin. 1972, one of M.T.'s older brothers gave him a six string Decca guitar that he had won in a poker game from a fellow construction worker. "Play some music, and get famous or at least get laid" the older brother said in a hung over Sunday morning painful growl. That year he learned to play guitar, and his life was changed forever.


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CHICAGO – The stage play that Harry Lennix is in town to direct – "A Small Oak Tree Runs Red" – is in its last weekend, and is giving the actor/director the best notices of the theater part in his long and successful career. For more information about the play, and ticket availability, click here.
Video: First-Look Trailer For 'L.A. Noire' With Kevin Scott Allen From Rockstar Games
CHICAGO – The first proper reveal of the new video game "L.A. Noire" from Rockstar Games was released on Thursday. The game, which is coming in 2011 to Xbox 360 and PlayStation 3, features TV stars Kevin Scott Allen and Aaron Staton.
Allen has appeared in "Desperate Housewives," "Mad Men," "Cold Case," "Prison Break," "Criminal Minds," "The Sopranos," "24," "Alias," "L.A. Heat," "Unsolved Mysteries," "Dragnet," "General Hospital" and "The Young and the Restless". Staton stars in "Mad Men". The new trailer for "L.A. Noire" can be watched now below.
By ADAM FENDELMAN
lead actor
The lead actor of the game (as evidenced by the trailer) is actually "Mad Men" actor Aaron Staton.
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We've updated the article to include him. Thanks!
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Take a peek at some exciting new films on the way!
We've rounded up some of the cutest, raciest and fun celebrity Instagram and Twitter pics from the past 24 hours featuring Salma Hayek, Madonna, Lucy Hale, Nicole Richie and Ludacris. …
The "revamped" remake is officially here. …
Here's all the movies you don't wanna miss!
"There's a gay James."
Happy early birthday, James Franco! …
Nothing takes the edge off a stressful situation like some wisdom from the people who've come before you…
Get caught up on all the film roles your fave celebs will be taking on next including Daniel Radcliffe, Idris Elba and Charlize Theron.
In case you didn't know, now you know: James Franco is in a band called Daddy and his next big TV role is the lead in a period porn drama called The Deuce, which was just given a series pickup from HBO.
We scoured the internet for stories you might have missed featuring all your fave celebrities including Ronda Rousey, Lorde and Ricky Gervais.
Is that Fabio? …
Get your double-tapping finger ready.
Your life. Your Franco.
Filming has started for James Franco's new film, The Disaster Artist, and this pictures of him and brother Dave Franco has the two appearing unrecognizable in their wigs and makeup.
Tis' the season of giving!
Keep calm and audiobook on.
A happy holiday is as simple as a box of hallucinogens, all tied up in a bow.
James Franco just did what everyone secretly wishes they could do. He got a (temporary) tattoo of Emma Watson's face on his neck. …
A panic attack has never been so irresistible.
We've rounded up some of the cutest, raciest and fun celebrity Instagram and Twitter pics from the past 24 hours featuring James Franco, Matt McGorry, Kylie Jenner and more.