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Feed aggregator
Philip Morris presentation on using social trends of young...
Philip Morris presentation on using social trends of young adults, such as skateboarding and "grunge," to guide marketing strategies…
Read the entire document at: https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/pnld0022
Title: MARLBORO RESEARCH PRIORITIES 950000
Document Date : 1995
Got more time to browse? See the more than 5 Million documents in our Philip Morris Collection
A Fond Farewell
The Archives has recently had the pleasure of hosting three outstanding volunteers/interns, all of whom are moving on to greener pastures this month. While we are sad to see them go, we are grateful for all the excellent work they did, and wish them well on their continuing journeys. Below is a brief synopsis of their accomplishments in their all too brief time at the Archives. Many thanks to Phoebe, Jessica, and Kristin!
Phoebe Jones
During the eight months that she has volunteered at UCSF A&SC, Phoebe has been a great pleasure to work with. Despite never having worked in a library or archives, she has shown great aptitude for archival work, both in processing collections and using the ArchiveSpace collection management system. Her work on the UCSF Committee on Arts and Lectures records in particular was instrumental in materials from that collection being digitized by the National Endowment for the Humanities (NEH) grant-funded California Audiovisual Preservation Project. She has also been a great help in other A&SC projects, including assisting with the Archives Lecture Series, and contributing to the A&SC blog and social media. Her dedication and enthusiasm has been a great asset, and she will be sorely missed.
Jessica Jones
A participant in the Excellence through Community Engagement & Learning (EXCEL) Program, Jessica has been a great addition to the Archives team for the past four months, especially in her work rehousing, organizing and creating the inventory for the Portrait section of the Photograph Collection. She was an essential member of the State Medical Society Journals project team and helped with volumes review for digitization, page estimation and conducted quality control. She also contributed to the Archives & Special Collections digital initiatives by digitizing and creating metadata for material from the Black Caucus records, and helped rehouse and inventory numerous manuscript collections, including the Laurie Garrett papers. Jessica has successfully completed the EXCEL program, and was even selected as one of the student speakers at her graduation.
Kristin Daniel
Although she has only been with us for a few short months, Kristin has been an excellent intern for UCSF A&SC. We especially appreciate her help starting the massive survey of our archival collections, a project that will greatly increase department efficiency, intellectual control, and user access once it is completed. Kristin has also assisted in organizing and inventorying the archives biographical files, performing quality control on digital files for the State Medical Society Journals project, and any other projects that we assigned to her. A soon-to-be graduate of San Jose State University's iSchool Masters in Library and Information Science program, Kristin is certain to find a professional librarian position in the near future.
The Mystery Doctor's Bag
We don't know much about this doctor's bag. It was manufactured by the Feick Brothers medical supply company, probably in the late 19th or early 20th century, in a manner common to the bags that family doctors carried during that time, but much beyond that remains a mystery. We aren't sure whose bag it was, or how it came into the possession of UCSF Archives & Special Collections. Beyond being a doctor's bag, we don't know if it has any connection to UCSF at all.
Even the tools inside the bag invite more questions than give answers: Were all these tools original to this particular bag, or were more tools added after it fell out of use? Is that a bullet extractor scoop, a curette spoon, or a lithotomy instrument? And it seems to have a lot of instruments related to gynecology and child birth—could it perhaps have been the bag of some nameless OBGYN?
For archivists, who rely on provenance to establish historical context, these types of questions can be a little uncomfortable. Yet despite all its mysteries, this doctor's bag remains a fascinating artifact—and it definitely has some very interesting things inside. It's almost like unwrapping a gift to discover it is actually a puzzle!
Written by David Uhlich.
Remembering Helen Gofman
This is a guest post by Kristin Daniel, UCSF Archives & Special Collections Intern.
The UCSF Archives is pleased to announce the official addition of the Helen Fahl Gofman papers. This collection, spanning several decades between the 1950s and the 1980s, details a woman who was a much loved teacher, mentor, doctor, and leader. Dr. Gofman's affiliation with UCSF pediatrics began in 1945 when she graduated from the School of Medicine and also completed her internship and residency on campus. Gofman received faculty status in 1953 and worked in various programs until her retirement in 1983. Gofman is best remembered as a founding member, and then director, of the UCSF Child Study Unit (CSU).
Helen Gofman was, by all accounts, a passionate and cheerful woman. She was dedicated to the care of the "total patient"—not just the physical or mental condition of the child, but also how that condition impacted their social, emotional, developmental, and behavioral well-being. Considered a national leader in the field of behavioral pediatrics, Gofman was involved with UCSF's Child Study Unit (now known as the Division of Behavioral and Developmental Pediatrics) since its inception in 1948.
Dr. Gofman and the rest of the CSU staff of doctors, nurses, social workers, speech pathologists and special education experts sought to help children whose conditions might have otherwise been misdiagnosed or gone untreated (including cases of dyslexia or ADHD) by other healthcare professionals. The goal of the CSU was not only to help these children and their families, but also to develop a new generation of pediatric health professionals; the CSU trained clinicians to value their patients and focus on finding personalized treatments that take into account all aspects of the child's life, not just their condition.
The Helen Gofman papers (MSS 2014-17) include research subject files, restricted patient files, and personal correspondence. Also included are some of Dr. Gofman's published works, such as The Family is the Patient: An Approach to Behavioral Pediatrics for the Clinician, which is considered a classic work in the field. Multimedia artifacts (such as lecture slides, teaching toys, and film reels) are also included. The Archives is proud to house this material and make it available to researchers.
Announcing our New and Improved Industry Documents Bibliography
The UCSF Industry Documents Library has been hard at work for this month's release of documents and features.
1) 825 new tobacco documents were posted to the Truth Tobacco Industry Documents yesterday.
- This includes 30 previously confidential videos from PM that have been made public and can be streamed
2) The improved Industry Documents Bibliography!
Our Bibliography is a running list of papers and publications created using our industry documents. It has long been a helpful tool for research and education and we are excited to unveil the new interface today.
The Bibliography now lives on the Industry Documents Library site and can be found by clicking on "Bibliography" in the menu bar.
Depending upon which industry you start from (IDL, tobacco or drug), you will see citations for publications and papers based upon that specific industry archive's documents. For instance, if you access the Bibliography from the main IDL home page you will interact with citations from both Tobacco and Drug documents but if you access the Bibliography from the Tobacco area, you will only interact with tobacco document citations.
Key features for the new Bibliography:
- Searchable!
Our new Bibliography interface allows you to search in the citations for keywords, authors and titles and also allows you to facet results by Category and Reference Type. Click on the title link or the URL in the Link field to access the publication directly.
- "Newly Added" citations will be tagged with the "newly added" status so that these recent citations can be found quickly by users.
At this time we have 11 newly added citations to the Industry Documents Bibliography.
- Direct links to the documents cited
You will note in each citation record, there is a "Document Cited" field which holds the IDs of industry documents used as primary sources. If you click on one of the IDs in the "Documents Cited" field, you will be taken to the document record.
Conversely, if you are searching in the documents, you will notice links to a Bibliography citation from the search results and the document view if the document has been cited in one or more papers.
The new and improved Industry Documents Bibliography reflects all industries and will grow as we grow our document collections. As you browse the citations and take a look around, please let us know how it's working for you and if you have any suggestions.
"A scientific publication plan is as vital as a carefully...
"A scientific publication plan is as vital as a carefully designed media plan in overall [drug] marketing."
Documents in the UCSF Prempro Products Liability collection reveal how pharmaceutical companies promote their drugs, including the use of vendors to produce ghostwritten manuscripts for placement in medical journals. The large pharmaceutical company, Wyeth, submitted dozens of these ghostwritten reviews and commentaries to medical journals specifically to promote off-label uses and diminish the perceived risks of breast cancer associated with hormone replacement therapy (HRT).
This document, from the early 2000′s, reveals how Wyeth sought to "set the scientific agenda" through "strategic publication" placements for their Prempro product, a hormone replacement therapy drug. This meant publishing articles in as many core journals as possible as well as presenting posters and speakers at symposia, conferences and CME events.
One slide titled "Core Messages," urges sales personnel to "challenge perception that ERT/HRT causes BC [breast cancer]" and "minimize impact of negative findings" when it comes to CVD.
Read the entire document at: https://www.industrydocumentslibrary.ucsf.edu/drug/docs/lmbw0217
UCSF Industry Documents Library, Drug Industry Documents archive
Title: Publication Planning and Management
Document Date: 2000/2001 est.
Songs of a Nurse…
We would like to commemorate this International Nurses Day by sharing with you a poem that was written by a San Francisco nurse, Margaret Helen Florine a century ago:
This poem comes from a book, Songs of a Nurse that was published in 1917.
Ms. Florine's poetry was later advertised in the Pacific Coast Journal of Nursing (volume 15, 1919, p.770).
Upcoming Lecture: Heightened Expectations
Date: Tuesday, May 17th, 2016
Time: 12 pm – 1:15 pm
Lecturer: Aimee Medeiros, PhD (UCSF)
Location: Lange Room, 5th Floor, UCSF Library – Parnassus
530 Parnassus Ave, SF, CA 94143
This event is free and open to the public. Light refreshments will be provided.
REGISTRATION REQUIRED: http://calendars.library.ucsf.edu/event/2544252
Join UCSF Archives & Special Collections for an afternoon talk with author Aimee Medeiros as she discusses her book Heightened Expectations: The Rise of the Human Growth Hormone Industry in America.
Heightened Expectations is a groundbreaking history that illuminates the foundations of the multibillion-dollar human growth hormone (HGH) industry. Drawing on medical and public health histories as well as on photography, film, music, prose, and other examples from popular culture, Aimee Medeiros tracks how the stigmatization of short stature in boys and growth hormone technology came together in the twentieth century. Historical materials from the UCSF Archives collection were used in the research for this book.
Aimee Medeiros is an assistant professor of the history of health sciences at the University of California, San Francisco.
About the UCSF Archives & Special Collections Lecture Series
UCSF Archives & Special Collections launched this lecture series to introduce a wider community to treasures and collections from its holdings, to provide an opportunity for researchers to discuss how they use this material, and to celebrate clinicians, scientists, and health care professionals who donated their papers to the archives.
Article Spotlight: British American Tobacco's access to policy-makers in Cambodia
Every month, we highlight a newly published article along with a few key industry documents used by the author(s):
MacKenzie R, Collin J.
'A preferred consultant and partner to the Royal Government, NGOs, and the community': British American Tobacco's
access to policy-makers in Cambodia. Global Public Health 2016 04/15:1-17.
British American Tobacco Cambodia (BATC) has dominated the country's tobacco market since its launch in 1996. Aggressive marketing in a weak regulatory environment and strategies to influence tobacco control policy have contributed to a tobacco-related public
health crisis. BATC officials have successfully aligned the company with Cambodia's political and business leadership with the aim of gaining access to policy-makers and influencing the policy process. These connections have resulted in official recognition of BATC's purported contribution to Cambodia's economic and social development and has provided the company with opportunities to water down tobacco control regulation.
Key Documents from the UCSF Truth Tobacco Industry Documents:
- Corporate News: BAT Cambodia (1995)
Cambodia Tobacco Company, owned by businessman Kong Triv, becomes the local partner in the BATC joint venture with a 29% share.
- Indochina Company Plan 1996-1998
"…handling government officials both at provincial and national levels on a variety of topics needs to be addressed through lobbying and meetings. It is imperative that anti-tobacco marketing restrictions are pre-empted by a balanced counter view presented at the highest levels in government and the media."
- BAT Cambodia Company Plan: 1997 – 1999
Speaks of a need to "further build up on our relationship with the Government so as to protect our commercial freedom and ensure a level playing field on excise and related commercial issues"…Among BATC's greatest concerns were "policies on tobacco, role of regulation, environmental tobacco smoke and reasons for retaining freedoms to advertise".
- 1998-2000: BAT Cambodia Limited: British-American Tobacco Marketing Narrative
Objectives include: (1) Continue to promote the positive image of BAT Cambodia, and British American Tobacco. (2) Monitor the regulatory environment maintaining free market conditions allowing the Company to sell its products competitively. (3) Add value by supporting optimum trading conditions, especially in relation to excise and tariffs, and maintain consumers freedoms to smoke. (4) Crisis management concerning key areas for the period: security issues, trading issues, operational changes, political developments
Highlights from the Photograph Collection – Lost on the Shelf
You never know what you're going to find in an archives office. While the idealized vision is probably a mirror-image of the storage vault, with its neat rows of gray manuscript boxes and acid-free record cartons, this is almost never the case. Any flat surface can become a not-so-temporary resting place for the odd accession or accrual, or the item that was removed from its collection for research or exhibit, but has yet to find its way back to its proper housing.
This photograph of an early 20th-century surgical procedure was found a few weeks ago on top of one of our many filing cabinets. Who knows how it ended up there—or how long it had been waiting to be found again. Luckily, it carried a notation that it was from the Julius Comroe collection and the carton dedicated to illustrations for his book, Exploring the Heart. Looking at his notes, it is evident that Comroe had intended to use this photograph as the first illustration in his chapter on open heart surgery, but had later opted to use the Thomas Eakins painting, "The Agnew Clinic," instead. Unfortunately there are no other notations or attributions on the photograph or its folder to tell us more about it, but at least this orphan work has found its way home—and we were given this opportunity to share it.
CLE Quiz Video Series
The CLE Quiz activity has been well documented here on the Convergence blog and we are always looking for ways to better support the online assessment tool. In the past we provided CLE Tips for Finals, a CLE Quiz FAQ, CLE Exam Tips for Students, and have recently released a video series showcasing the CLE Quiz activity.
Just a reminder that the CLE uses the term "Quiz" for the activity, but do not be mistaken – the Quiz activity is a robust online assessment tool that can be used for self-evaluations, tests, exams, mid-terms, and finals at UCSF.
Are you preparing for an upcoming CLE exam or final? Take a look at the video series below to learn about creating, configuring, and grading a CLE Quiz.
The content is organized into three videos, and a bonus FAQ video. This video series is designed to help UCSF faculty and staff quickly find the information they need when administering an online exam in the UCSF CLE.
Add a Quiz Video
In this video we will add a Quiz to a CLE course and configure Quiz settings.
Add Questions to a Quiz Video
In this video we will create and add questions to a CLE Quiz.
Grade a Quiz Video
In this video we will grade a CLE Quiz.
Quiz FAQ Video
In this video we will review a few frequently asked questions about the CLE Quiz activity.
Have questions about these videos or about an upcoming CLE Quiz? Contact a Learning Tech Specialist or attend an upcoming Tech Clinic at the UCSF Library.
We have a Quiz Demo scheduled for the May 13 Tech Clinic, from 1:30-3pm. Join us at the UCSF Library for a demonstration and conversation on the power of the Quiz activity! Click below to learn more and register:
Learning Tech Specialists are also available to help review CLE quizzes with faculty and course staff before a high-stakes exam such as a midterm or final. We call this a Quiz Preflight and it only takes 10-15 minutes to confirm quiz settings are configured correctly.
Remember to visit the UCSF Learning Tech Support Center to view our growing collection of CLE support videos and for additional Quiz support!
Image Credit: Moodle Trust
New Collections on Calisphere
Earlier this year the California Digital Library revealed a revamped Calisphere site, offering improved access to and usability for thousands of digital items of historical significance contributed by institutions from across California. Alongside University of California partners such as UCSF, California State University Libraries, public libraries, museums and historical societies are making digital resources more discoverable than ever. The Calisphere site itself features excellent search and filter functions, and items can also be discovered through the Digital Public Library of America and even through Google searches.
UCSF is currently adding items and collections to the site, beginning with newly digitized items from the Eric Berne Papers, Lawrence Crooks Radiologic Imaging Laboratory Records and the UCSF Black Caucus Records. Other collections include the Japanese Woodblock Print Collection, the Tobacco Free Project (SF Department of Public Health Records), and selections from UCSF's Photograph Collection. We're also moving items over from our Omeka site so that all of UCSF's digitized items can be accessed in one place.
The release of the new Calisphere site also coincides with the implementation of a new Digital Asset Management System (DAMS) connected to Calisphere, that with help from CDL, allows us to have an efficient workflow for managing, preserving and publishing digital items.
You can find UCSF's collections through the "Contributing Institutions" link at the top of the page. Each collection features a gallery view with thumbnails of the items, with options to filter and sort search results and sets by an number of different facets including date, item type and collection number.
Calisphere's new user-friendly features include clearly laid-out item information and a nice co-mingling of academic and social media functions to "Get Citation" "Tweet" and "Share on Facebook". There are also helpful links back to the Contributing Institution page and Collection page and links to the finding aid on the Online Archive of California. The new design is very easily searchable, navigable and easy on the eyes.
We'll have more items coming online in the next month or so keep an eye out. Take a look around the site, send us your feedback and enjoy!
"Life Causes Death!" & "The Greatest Myth of the Century:...
"Life Causes Death!" & "The Greatest Myth of the Century: Passive Smoking is a major problem" - Incredible copy ideas from a 1993 Philip Morris brainstorming session to develop new marketing messages in Europe.
Document from a PM meeting charged with forming new messages for the European market that would focus more on social issues and approaches instead of health messages. In addition to full-page ad scenarios, and possible "novel approaches to research", the participants suggest alternative names for ETS (environmental tobacco smoke) including calling it, of all things, "second-hand smoke", a label the industry actively discouraged for years.
One ad scenario called "The Hidden Minority…Which of these people is most commonly discriminated against?" was to be accompanied by a picture of a "smoker, a drug addict, a minority race, a homosexual and a woman." Another campaign called "Is American Intolerance/Puritanism Coming to Europe?" argued there is a "dangerous puritan, fundamentalist movement in the US" and "the anti-smoking groups are one part of this movement."
Read the full document at: https://industrydocuments.library.ucsf.edu/tobacco/docs/plvv0111
Source: UCSF Industry Documents Library, Philip Morris Collection
UCSF Archives Coloring Book
We created a coloring book featuring illustrations from fifteenth to nineteenth-century rare books housed in the UCSF Archives and Special Collections. Coloring reduces stress, inspires creativity, and it's just plain fun. You can scroll through a few of the images below and download the entire book for free here. Happy coloring!
We would love to see your finished creations. Tweet your pictures @ucsf_archives and use #ColorOurCollections.
Download the complete UCSF Archives and Special Collections Coloring Book
Over 7000 New Tobacco Documents Posted
7,133 new tobacco industry documents were posted to the UCSF Truth Tobacco Industry Documents today.
The breakdown is:
- 132 Brown & Williamson documents
40 Philip Morris documents including 6 new videos files
77 new depositions and trial transcripts from the recent Engle Progeny cases in 2015
Senator Jesse Helms - Thank you for continuing to be the...
Senator Jesse Helms - Thank you for continuing to be the champion of the tobacco industry.
James Maguire, exec sales with RJ Reynolds, penned a letter to Senator Helms in 1993 outlining the catastrophe that would befall the country if an additional tax were placed on cigarettes. Maguire claims, "Smokers and the tobacco industry are already paying an unfair tax burden."
Source: https://industrydocuments.library.ucsf.edu/tobacco/docs/kzph0023
UCSF Industry Documents Library, RJ Reynolds Collection
Author : MAGUIRE JV
Document Date : 1993 March
Society of California Archivists Annual General Meeting
We'll be out of the office at the end of this week, April 7-9 for the Annual General Meeting of the Society of California Archivists.
It's a Northern California year, archivists from across California will be gathering in Santa Rosa for three days of tours, workshops and sessions.
Highlights include a workshop and case study presentations on Stanford's ePADD email processing project, a lunchtime talk on San Francisco street food, and especially pertinent for us a plenary address by Sonoma State history professor Michelle Jolly on connecting the current generation of students with an awareness of archives and primary sources.
Local institutions opening their doors for tours include Sonoma State University Special Collections, Santa Rosa Junior College Archives and the Charles Schulz Museum
We're looking forward to learning and sharing a lot, we'll be back on Monday, April 11.
Early MRI technology on display now at the UCSF Library
The UCSF Archives and Special Collections is pleased to announce the opening of a new exhibit at the UCSF Library, Vision for the Future: Advancing MRI Technology at UCSF's Radiologic Imaging Laboratory, 1975-2000. The exhibit explores the pivotal role UCSF researchers played in developing imaging technology that revolutionized patient care and transformed the way we see our bodies. View material from the Radiologic Imaging Laboratory records housed in the UCSF Archives, including research notebooks, MRI coil prototypes, rare photographs, and more.
Join us April 5th at 12 noon for the exhibit's official opening. Archivists will be on hand to answer any of your questions!
The Radiologic Imaging Laboratory (RIL) was founded in the mid-1970s by a team of UCSF scientists and engineers. Their goal was to create a clinically viable diagnostic tool using nuclear magnetic resonance imaging, later called MRI. Over the course of 25 years, the lab brought together venture capitalists, researchers, and clinicians to develop, evaluate, and market new imaging systems and instruments. The lab's interdisciplinary approach and partnerships with private corporations, including Pfizer, Diasonics, and Toshiba, led to rapid innovation and numerous patents that continue to impact clinical care today.
The exhibit showcases just a fraction of the over 90 linear feet of engineering records, correspondence, and other material in the collection (call number MSS 2002-08). Through the generous support of RIL engineer, Dr. Lawrence E. Crooks, the UCSF Archives has processed the collection and created a detailed inventory available to researchers on the Online Archive of California. Archives staff have also made hundreds of documents and photographs from the collection available digitally on Calisphere, a public online portal.
The exhibit is located on the main floor (3rd floor) of the UCSF Library, 530 Parnassus Ave. It is free and open to the public during Library hours, April 2016-April 2017.
Conquering the CLE Gradebook
The gradebook is a powerful module that is available in every CLE course, though it can be intimidating to new course editors. It allows instructors to organize and calculate grades, and it allows students to view their own grades. The gradebook offers a number of customization options, and it can accommodate simple or complex grading schemes. With this blog post, we are happy to announce a new collection of help resources all about the gradebook!
Have you ever wondered how extra credit works in the gradebook? Do you want to make a back up copy of grade histories for safe keeping? How do you capture grades from in-class assignments that have no electronic component on the CLE course home page? All of these questions, and many more, are answered in the following help documents. If you aren't sure where to look, don't hesitate to contact us, and we'll point you in the right direction. Happy grading, and good luck!
- Gradebook Handout (detailed, printable guide, PDF)
- Gradebook Introduction (online documents covering basic concepts)
- Gradebook Tips (online documents covering additional tips and tricks)
- Gradebook FAQ (online list of commonly asked questions and answers)
Also note that this easy-to-remember URL will take you directly to the introduction article: tiny.ucsf.edu/gradebook.
Announcing a New Online Workshop: Foundations in the CLE
We are pleased to announce a new online workshop designed to teach you how to perform basic tasks associated with building a course or collaboration space in the Collaborative Learning Environment (CLE)!
The purpose of the Foundations in the CLE workshop is to help new users who are tasked with creating or editing courses. The four-hour online training is self-paced and includes a basic overview of the CLE, an introduction to the interface, and information about adding tools and resources to your courses.
Participants can self enroll by simply logging in to the CLE and searching for the course or just click the button below to enroll now!
Have questions on how to get started? Contact a Learning Tech Specialist or just leave a comment below!


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Orange Snaps Up Atheos - Analyst Blog
Orange Business Services ("OBS"), a subsidiary of Orange ( ORAN ), has beefed up its enterprise security service market share with the buyout of cyber defence company Atheos, for an undisclosed sum. The French incumbent claims that the acquisition will make it the numero uno player in Europe's cyber defence sector.
The acquisition will give Orange leverage in network access control, data loss prevention and on-site crisis management, thus allowing it to offer multidimensional security for its clients. Following its integration with Atheos, the French carrier wants to operate under the Orange Cyberdefense brand name.
Atheos has 130 employees working with large French firms to accurately implement their security strategies. The size and infrastructural strength of OBS will help Atheos in delivering critical security solutions.
At present, OBS is supported by 8 security operations centre and its service is available in more than 220 countries and territories around the world. The subsidiary continues to strengthen its SAAS (Security as a Service) services as part of its Conquests 2015 strategic plan, which aims to improve operational efficiency by sharing different practices and business models to enhance group development.
Globally, enterprises are facing an increased number of hidden security threats and need to remain updated about the risks that they could face. OBS provides companies with cloud-based IT security solutions to analyse and manage their office security and take appropriate action, when necessary.
Orange Business Services is expected to deliver more than 10% growth per year through 2016. We believe this acquisition will fortify Orange's security service business and offset its declining wireless business. It will also help the company to capitalize on the growing opportunity in the cloud-based security market.
Orange currently carries a Zacks Rank #3 (Hold). Other stocks to consider within the same industry are Ceragon Networks Ltd. ( CRNT ), China Unicom Hong Kong Ltd. ( CHU ) and Fairpoint Communications Inc. ( FRP ). All these stocks currently carry a Zacks Rank #2 (Buy).
CHINA UNICOM (CHU): Free Stock Analysis Report
CERAGON NETWRKS (CRNT): Free Stock Analysis Report
FAIRPOINT COMM (FRP): Free Stock Analysis Report
ORANGE-ADR (ORAN): Free Stock Analysis Report
To read this article on Zacks.com click here.
Zacks Investment Research

subset: commoncrawl


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Students Motivated To Explore Future
Posted: 12/11/2009 - Manhattan High School students were motivated to explore the future right before the Thanksgiving holiday break last week by completing a scavenger hunt using the American Careers magazine.
Posted: 12/11/2009 - Manhattan High School students were motivated to explore the future right before the Thanksgiving holiday break last week by completing a scavenger hunt using the American Careers magazine.
Posted: 12/11/2009 - Due waterline break on the south side of the downtown poast office 5th Street and Kansas Ave., workers were forced to move the nearby drop-off mailboxes.
Posted: 12/11/2009 - A 72 year-old woman from the Wichita metropolitan area is the 22nd Kansas death from infection with the H1N1 influenza virus.
Posted: 12/11/2009 - A waterline break on the south side of the downtown post office, 5th Street and Kansas Avenue, required workers to remove the drop-off mail boxes.
Posted: 12/10/2009 - Stephanie Zelnick will peform at an international clarinet festival in Austin, TX and with an ensemble in Taiwan.
Posted: 12/10/2009 - Texas Roadhouse will donate 10 percent of proceeds from gift card sales Dec. 14 to the United Way of Greater Topeka.
Posted: 12/10/2009 - 56-year old Greg Mitchell is jailed on a charge of criminal threat.
Posted: 12/10/2009 - No power at the annex today.. but offices at the Courthouse will still be open for operation on Friday.
Posted: 12/10/2009 - KDHE wants to hear from homeowners who think they may have the Chinese drywall at the center of a federal investigation.
Posted: 12/10/2009 - The cold weather can create some very real health concerns.
Posted: 12/10/2009 - The energy efficiency improvements to the Osage County facilities could cut their yearly costs by $23,000.
Posted: 12/10/2009 - 25-year-old William Roberts has a preliminary hearing set for Jan. 14.
Posted: 12/10/2009 - It hasn't always been Westar Energy.. but in its varied forms, the company is marking 100 years of service Friday, with parties at regional offices.
Posted: 12/10/2009 - The man accused of a Thanksgiving weekend tragedy was back in court Thursday. (VIDEO INCLUDED)
Posted: 12/10/2009 - A January 5th court date is set for Ariezanna Williams.
Posted: 12/10/2009 - The U.S. Postal Service has reminders for holiday mailing deadlines.
Posted: 12/10/2009 - Kansas recorded its 22nd confirmed death from the H1N1 virus.
Updated: 12/10/2009 - The attorney for two men shot and injured by off-duty Topeka Police Officers is speaking out.
Posted: 12/10/2009 - Wilson said the responsibilities for preparing a financial report for the cities, townships, and school districts was taken away from his office before he was elected treasurer.
Posted: 12/10/2009 - Spencer could have gotten a life sentence in June 2008, after pleading guilty to sexual charges involving a 6 year old and 7 year old, but then District Court Judge Matthew Dowd gave the then 75 year old 3 years probation.
Posted: 12/10/2009 - Jana Mackey's family is moving her efforts forward with Jana's Campaign to Stop Violence Against Women. It is a group of almost 50 advocates dedicated to bringing the issue to the top of the public consciousness.
Posted: 12/10/2009 - The Kansas Coalition Against Sexual and Domestic Violence is urging communities to reassess what they can do to respond to the needs of battered women and children more quickly and safely.
Updated: 12/10/2009 - Attorney General Steve Six says 15 people are charged in Jackson County with identity theft related crimes as part of Operation Imposter.
Posted: 12/10/2009 - The Kansas Lottery has a cool job listing, and so does the National Park Service in our listings from www.kansasworks.com this week.
Posted: 12/10/2009 - With the temperatures dropping, the Topeka Fire Department is encouraging people stay safe on the ice.


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Organic salts are generally the preferred crystal form of active pharmaceutical ingredients because of their higher solubilities and/or increased degree of crystallinity. The potential number of suitable organic salts is limited to the counterions specified by the food and drug association (FDA) as GRAS (generally regarded as safe). A recently suggested alternative to the common inorganic salts is the preparation of cocrystals1 or organic salts, some of which have been shown to improve therapeutic utility while reducing side effects.2–4
Candidates for cocrystal formation with a particular structural motif for achieving desired physical properties5, 6 are chosen on the basis of their ability to utilize known intermolecular interactions in forming those crystals. Because hydrogen bonds are among the strongest and most preferentially directional intermolecular interactions, they have been the leading candidates for the interactions to be utilized in forming cocrystals,7–10 although other interactions have also been suggested.11a,b
Particular preference in the development of the strategy for cocrystal formation utilizing hydrogen bonds has traditionally been based on the tendency of carboxylic acids and amides12, 13 to form the homo- or heterointermolecular synthons14–16 described in Etter's graph-set notation17, 18 as an (8) ring (which interprets as a ring (R) motif containing eight atoms with two hydrogen-bond donors (subscript) and two hydrogen-bond acceptors (superscript); Scheme 1). 1However, other hydrogen-bonding motifs such as (4) (Scheme 1), 1have also been investigated.19, 20 Herein we demonstrate the potential for utilizing another, as yet little recognized and not yet utilized, hydrogen-bonded synthon (8) (Scheme 1).1
A survey of the Cambridge Structural Database (CSD version 1.8, 2006) has identified over 12 000 instances of this synthon, virtually all of which involve four individual and nonconnected (but not necessarily chemically different) moieties in the solid state. Many of these cases involve two chemically different moieties, often resulting in a pattern that is crystallographically centrosymmetric or pseudocentrosymmetric. Perhaps the most remarkable feature about this synthon in terms of cocrystal formation is that it potentially involves the intermolecular recognition and supramolecular synthesis of four different molecules.
In the CSD, there are 918 hits for structures utilizing the (8) synthon (Scheme 1) 1in which the donor is the amino group (NH2) and the acceptor is the carbonyl group (CO). These are broken down into specific functional groups like (CO)O−, N(CO), N(CO)N, (CO)OH, C(CO)C, C(CO)H, -NH3+, CNH2, NH4+, and NNH2. This survey clearly indicates that the highest incidence of participation in the (8) synthon is for carboxylate acceptors and ammonium cation donors.
In our cocrystallization attempts to achieve this synthon, we chose to use amino acids, starting with γ-amino butyric acid (GABA). As the CSD search indicated a preference for the ionized species -NH3+ and COO− in the formation of the desired (8), we attempted crystallization in the pH range for which the amino group of GABA will be in the form of -NH3+ and the carboxylic group of the oxalic acid and benzoic acid will be in the form of -CO2−. The molar fractions21 for the ionized species in different pH ranges can be calculated from the pKa values of the acid and base. Figure 1 1represents the calculated molar fraction for GABA and oxalic acid. For GABA, pKa=10.43, pKb=9.77, and the isoelectric point is pI=7.33. For oxalic acid, pKa1=1.23 and pKa2=4.19. It is clear from Figure 1 1that the crystallization for a 1:1 GABA/oxalic acid cocrystal should be carried out in the pH range 0–4.19 and crystallization for 2:1 cocrystal ratio should be carried out in the pH range 4.19–10.43. Our initial experiments were carried out at pH 5.
The same calculations and molar fraction diagrams were prepared for the crystallization of GABA and benzoic acid. The pKa value for benzoic acid is 4.19, which is the same as GABA. The crystallization attempts were carried out at three different pH values: 4, 6, and 12. At pH 4, the two species of benzoic acid and the two species of first dissociation of GABA are in equilibrium (see the Supporting Information). Experiments on oxalic acid and GABA yielded a 1:2 cocrystal of GABA/oxalic acid. As expected from Figure 1, 1GABA is protonated and the oxalic acid is a dianion. Charge neutrality therefore requires a 1:2 ratio of GABA and oxalic acid.
The crystal structure shown in Figure 2 2clearly reveals three of the four hydrogen bonds required to complete the (8) synthon. The donor–acceptor (D⋅⋅⋅A) distances, a=1.913 Å, b=2.517 Å, and c=2.063 Å, are in the range of normal hydrogen bonds. The distance d (3.242 Å) is considerably long for an NH⋅⋅⋅O hydrogen bond, but the incipient pattern of the synthon (8) still appears to be utilized in this structure.
Additional crystallizations were carried out at pH 0, 3, and 12. The results of X-ray powder diffraction (XRPD) studies, when compared with those of the starting materials (Figure 3 A), 3indicate the presence of new crystalline phases (polymorph, hydrate, or differing stoichiometry) of the resulting powders. However, crystals suitable for structure analysis have not yet been obtained. These new phases can result from the different species coexisting at each pH value. From the crystal structure obtained at pH 5 (Figure 2), 2the acceptor that participates in the hydrogen bonds that are labeled a–d is the carboxylate group of GABA. This species can exist only above pH 4 (Figure 1). 1This fact can account for the different phases at the pH values of 0 and 3. One possibility for the appearance of a different phase obtained at pH 12 is that the donor for all the hydrogen bonds that participates in the hydrogen bonding is the amino group of GABA, which is protonated below pH 10 (see Figure 1); 1above this pH value (e.g. pH 12), the amino group will not be protonated and will likely participate in different hydrogen-bonding patterns.
A cocrystal of 1:1 benzoic acid/GABA was obtained from aqueous solution at pH 4. The small colorless crystals appeared a few minutes after adding water to a mixture of the solids. In the structure, the GABA is protonated and the benzoic acid is in the anionic form. Charge neutrality therefore requires a 1:1 ratio of GABA and benzoic acid. Figure 4 4clearly reveals that the crystal structure utilizes two instances of the (8) synthon with hydrogen bonds a and b common to the two synthons.
We have described a strategy to design cocrystals based on the (8) synthon by using pH as a controlling tool. Two cocrystals were obtained with the active pharmaceutical ingredient GABA, namely (GABA)2 oxalate and GABA benzoate. The identification of other robust and versatile synthons can be utilized as an aid in the selection of potential cocrystal formers. Note that in the course of this work, we have also isolated and obtained the crystal structure of two previously unreported hydrates of oxalic acid, a dimorphic sesquihydrate. These will be reported in due course.


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Dr. Dobb's Archive
On this site is archived all the content from Dr. Dobb's that was published on the Web through December 31, 2014. - Architecture & Design
RESTful Web Services: A Tutorial
As REST has become the default for most Web and mobile apps, it's imperative to have the basics at your fingertips.
Why Build Your Java Projects with Gradle Rather than Ant or Maven?
The default build tool for Android (and the new star of build tools on the JVM) is designed to ease scripting of complex, multi-language builds. Should you change to it, though, if you're using Ant or Maven?
Developer Reading List: The Must-Have Books for JavaScript
The best books for learning the basics, becoming expert, and and writing complete apps in JavaScript
Windows 10 Build 14393 Rollout, Cloud Revenue: Microsoft Roundup
Google Cloud Platform Adds Machine Learning APIs
Many Businesses Using AI Without Realizing It
SAP Second Quarter Earnings Shrug Off Brexit
Google's DeepMind AI Cuts Data Center Power Bills
Imperson Chatbot Platform For Enterprises Released
Microsoft Cloud Drives $22.6 Billion In Revenue
IBM's Cloud, Analytics Investments Start Paying Off
Events of Interest
December 11-12. Washington, D.C. ModevCon
March 2-6, 2015 London, UK. QCon London
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April 8-16, 2015. Montreal, Canada. PyCon 2015
April 27-30, 2015. Baltimore, MD. 11th Software Engineering Institute (SEI) Architecture Technology User Network (SATURN) Conference
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May 12-14, 2015. Zaragoza, Spain.Protocols Plugfest Europe 2015
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September 2013. JavaOne
June 2013. JAXConf 2013
May 2013. Google I/O
October 2012. JAXLondon 2012
September 2012. Strangeloop
July 2012. Java Language Summit
June 2012. Google I/O 2012
May 2012. Atlassian Summit
May 2012 (paid). Fluent Conference
March 2012. Multicore World
July 2011. JVM Language Summit


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What's new: 'Zack & Zoey Explore the Articles of Faith' DVD/CD provides entertainment, music and teaching
"ZACK AND ZOEY EXPLORE THE ARTICLES OF FAITH," music by Lex de Azevedo, Excel Entertainment, $21.98, 62 minutes
Sometimes explaining concepts and terms discussed and taught in The Church of Jesus Christ of Latter-Day Saints can be a difficult task, especially when talking to children.
Teaching such principles has become simplified thanks to "Zack & Zoey Explore the Articles of Faith" with music by Lex de Azevedo, a Golden Globe nominee known for productions such as "Saturday's Warrior" and "My Turn on Earth." Designed for children to watch and listen to individually or with their families, the DVD uses fun animation, captivating music and commentary by children to teach and explain each of the Articles of Faith, written by Joseph Smith. The CD includes all of the songs performed in the DVD.
Children of different ages and ethnicities, many from Utah, perform in the children's choir and orchestra and use dance to share de Azevedo's all-new Article of Faith songs. After each song, Zack and Zoey and the other children explain difficult terms and teach what each declaration means. They use simple terms kids of all ages can understand.
Use of animation also visually depicts the narration. Additionally, Leah Coleman from "Signing Time" provides American Sign Language alongside many of the songs.
This DVD and CD combination would make a great family home evening activity or simply positive entertainment for children.
Wendy Jessen is a Southern Utah University graduate and a stay-at-home mother of six. Her email is email@example.com and she blogs at mormonmomofsix.blogspot.com.
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We stayed here for business for two nights. It is a pretty nice hotel.
The room was big and comfortable. I liked the seating area with a couch, a sitting chair and a desk and little kitchenette area complete with sink, microwave and fridge. The bed was very comfy and clean!
The full breakfast was your typical hotel breakfast with fresh waffles, eggs, sausage, assorted cereals, muffins, breads, oatmeal and juices. I really liked their selection of cold cereal, as it had something for everyone (Lucky Charms, Total, Cheerios, Golden Grahams, Cinnamon Toast Crunch, etc.)
The gym was a bit small and had only three pieces of cardio equipment, so people who value hotel gyms make not like this set up, but it worked for me.
It is close to I-5, Walmart, Harry and David, etc. Nice location and I will stay here again if the need arises!
- Official Description (provided by the hotel):
- Our SpringHill hotel in Medford, Oregon offers a complimentary hot and healthy breakfast buffet, fitness center and indoor pool to help round out your stay by energizing your body and lifting your spirits. Our all-suites hotel in Medford, Oregon keeps you productive yet pampered whether you're traveling for business or pleasure. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Hotwire, Hotels.com, Orbitz, Odigeo and Travelocity so you can book your SpringHill Suites Medford reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Springhill Suites Medford Hotel Medford
- Medford Springhill Suites


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Giving birth to a child and becoming a parent is a matter of greatest joy. The news of stork visiting the home bring a lot of happiness and the parents-to-be await the day when they would be able to hold the baby in their arms. Many of our celebrities are also excitedly waiting to welcome their n
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Rated 4.4 out of 5 by 240 reviewers.
Rated 5 out of 5 by chef2 AMAZING SERVICE THE ENTIRE STAFF WERE ACCOMMODATING AND FRIENDLY. I WAS VERY IMPRESSED WITH HOW HELPFUL AND KIND THEY WERE. October 25, 2014
Rated 1 out of 5 by jprado85 Poor Customer Service The hotel, view and room were all impeccable. However, the customer service lacked extremely, not including the bell hops. The concierge especially was extremely unprofessional and lacking in customer service. We were referred to a restaurant that was very poorly run, had terrible food and lacked in management. Upon returning to the hotel we let the concierge know out of courtesy how our experience was and that he might not want to make this recommendation to any other guests. He was beyond offended and took this personally. From this point on he would no longer give us directions, recommendations, or any help at all during our trip. Being from out of town, this put a huge wrench in our planning. He was extremely rude, offensive and overrated. After enduring this treatment each day/night we then had to retreat to our room with the beautiful view of the Opera. DO NOT book your stay here during a weekend. The hotel does not let you know that there are all night parties in the street and in front of the opera during the weekends. Loud music plays continuously until 4 am in the morning making it impossible to get any sleep. In addition to these major issues, I have had to ask the hotel 3 times for a correct PDF of my receipt that I still have not yet received. After alerting the manager during our departure of what we faced during our entire trip she was unapologetic and her only solution was that she would talk to the concierge to retrieve his side of the story. Excuse me? His side of the story? 4 of your guests just told you he was continuously rude to us and that is all you have to say? Unacceptable. Especially because I have stayed at many W hotel location in the United States and have always been EXTREMELY satisfied. This was a huge let down and I would not recommend this hotel to anyone. October 20, 2014
Rated 5 out of 5 by Osizi27 The W is Fantastic! The W Paris-Opera Hotel is just ideal. Everything checks off: Location is premium (Right next to the Legendary Opera) Staff is warm, friendly and Professional Chefs are really good The Hotel is tastefully furnished An Apple store is next door in the same building. I cant find one bad thing to say. Great Stay September 25, 2014
Rated 4 out of 5 by Lasvenska Best concierge ever! We had a very pleasant stay at W Paris Opera. The location is great. Walkable to many things. Staff is very helpful and I wanted to highlight the concierge service. Both Claremont and Marko were exceptionally professional and very helpful. Marko went the extra mile. He sent us emails with suggestions for shops and restaurants, called to remind us of our upcoming soccer game start time when we got mixed up on time and didn't show up to pick up tickets. We were very impressed! September 3, 2014
Rated 5 out of 5 by JLondon Paris business Very nice hotel, ideally located in central Paris. Friendly staff , know how to welcome SPG members! August 26, 2014
Rated 5 out of 5 by Ann1108 Gem of a hotel, perfect location The W in Paris was a beautifully appointed and a very centrally located hotel, across from the Opera Garnier and near many metro lines. The room was super modern and fun, and comfort and luxury were clear priorities. Our concierge was consistently wonderful throughout and employees were very responsive. There was a small mixup with housekeeping which resulted in our room not being made up one night--but the housekeeping manager was more upset bout this than we could be and quickly corrected it. All in all, an extremely good choice for us, and we were so happy with it. August 14, 2014
Rated 5 out of 5 by KPY33 Great service The service level at W Paris Opera is impeccable, well done. The lobby staff were responsive to some early hiccups. As for the room... I had an upgrade to a Spectacular Room... the view of the Opera House is unmatched. The bed can rival Westin's Heavenly Bed and the design of course is typically W. August 13, 2014
Rated 5 out of 5 by GregP Fantastic I had a great stay at this property. The only issue I had was with the cheeseburger, Bun was very dry. This is minor. I highly recommend choosing the W opera if coming to Paris. August 6, 2014
Rated 5 out of 5 by johnboynyc Excellent all around The accommodations and the staff really surpassed my expectations. Hotel is located in a convenient area, close to cafes, metro, and shopping. Staff were accommodating and attentive which made the visit so very enjoyable! August 4, 2014
Rated 5 out of 5 by Pulaski71 Great for romantic getaway/birthday surprise Never stayed at a W Hotel before, so was a little wary. Booked this hotel based on location and it didn't disappoint with lots of landmarks, museums, restaurants, and shops within easy walking distance. Reserved a Spectacular Room that was spacious & gorgeous with a fantastic view of the Opera House. Amenities were all top notch and the staff were absolutely amazing. I asked in advance for a delivery of flowers & champagne to room upon arrival for my wife's birthday, which was accomplished without hassle. Thomas was the MOST HELPFUL CONCIERGE we've ever come across. He was attentive to all requests and made sure we had everything we needed -- even going so far as to personally arrange for a private, romantic dinner at a reasonably-priced restaurant for wife's birthday. Can't say enough about our experience here as it made this romantic getaway even more memorable. August 3, 2014
Rated 5 out of 5 by DylanZ Wonderful Hotel at a Great Location I used my Starwood points to stay at this hotel. It's a fair number of points, but it's worth it. The hotel rooms are beautiful, the staff is extremely helpful, and the location, right across the street from the Paris Opera House (yes - THAT Paris Opera House) can't be beat. July 30, 2014
Rated 5 out of 5 by Cam63 Ultra-modern with all updated amenities. Rooms were spacious, ultra modern, clean, with wonderfully comfortable bedding. Staff was courteous and extremely helpful. Location could not have been better. The restaurant food and service were excellent. Concierge services were superb. Bruno and Thomas worked with us mostly, although everyone was top notch, including the desk receptionists and bellmen. I would not hesitate to stay there in the future. July 29, 2014
Rated 4 out of 5 by Meber99 Great hotel in an excellent location Great representation of the W brand. This is still a hip-like hotel and with more class than most. Rooms are tasteful and nice. Service was very good. As for meeting & event facilities, it was lacking on the service side. July 25, 2014
Rated 3 out of 5 by GlobalMe Passé been there, done that ideas of what was cool and trendy years ago. July 25, 2014
Rated 2 out of 5 by EZD92 Not our cup of tea We arrived early and they said they would call us when room was ready. No call. Very chic, modern design that does not flow well. Very small room. Shower would not shut. Toilet ran unless one fiddled with the lever. Cheeseburger was €27 (~$37) - are you kidding? A bit out of the way for the rates charged - way overpriced. Would suggest elsewhere. Concierge very nice and helpful though. July 17, 2014
Rated 5 out of 5 by gk10 Perfect Location Right next to the opera house, Galeries Lafayette, and walking distance to amazing shops. Great stay July 12, 2014
Rated 5 out of 5 by rubypearl Convenient, comfortable, friendly staff Perfect hotel for our 3 nights in Paris before embarking on our river cruise. Very clean, comfortable, friendly staff, perfect location. The concierges were exceptionally friendly and helpful especially marko, Bruno and Thomas. So were Milton and Tiago. We would stay here again any time we were in Paris. July 11, 2014
Rated 4 out of 5 by valentina2 W PARIS/OPERA GREAT LOCATION I loved this hotel. We wish the lobby were more dramatic, but overall very comfy even for a mom with child traveling alone. The staff was very kind, other then one instance where they couldn't understand me over the phone. Good food, and I'd stay longer if I could ! July 11, 2014
Rated 5 out of 5 by Jeff0704 Simply Outstanding We have visited Paris several times, and stayed at different hotels. This hotel has many advantages: It is ideally located in the center of all activities. The room was clean, with nice amenities. The staff is very friendly and efficient. The warmth of the staff, particularly Customer Relations manager (Ms. CR) and the General Manager (Mr. CM), and their genuine interest in the guests is exceptional. We were glad to be there to celebrate an important occasion, and look forward coming back. Thanks for great hospitality. July 4, 2014
Rated 5 out of 5 by JournalJim Perfectly located The only downside of the W in Paris is that most taxi drivers were unfamiliar with the hotel, or even with the Apple store. However, they all knew Place de L'Opera so that was no problem. The bed, the shower, the soundproofing and everything else was stellar. The lighting, however, leaves some work, as it was difficult to figure out how to turn on or off certain fixtures. But that was a small inconvenience to an otherwise superb experience. July 4, 2014
Rated 5 out of 5 by ppress Thanks for the wonderful stay It was a perfect stay for my daughter's birthday. The little extra attentiveness of all the staff was very much appreciated! Our room was very spacious and ready for us in no time at all. We'll definitely be back again! July 3, 2014
Rated 5 out of 5 by JenStar69 Above and beyond all expectations! Everything about this hotel and staff impressed me. Immediately on my arrival, I was greeted by a W agent along with the amazing W Insider, Cecile. I felt as though my family was welcoming me home after a long absence. My room had all the Parisian charm that you would expect along with all the modern styling I have come to love at all W hotels. It was well appointed, clean and comfortable. The restaurant was amazing with elegant offerings and excellent wine list. The manager took it upon himself to serve me as I was dining alone on my first night. This certainly made me feel more comfortable as all the other diners were in pairs or groups. The Sunday brunch is a must with an excellent buffet and chic atmosphere. Each day I encountered new W staff members who spoiled me with their smiles and warm greetings. It was a shame I could not take all of their names to write a personal note of thanks and appreciation. I have nothing but praise for the W Paris Opera. I am already conspiring my return! Well done! Bravo! A bien tot! July 1, 2014
Rated 4 out of 5 by Verified Reviewer Overall is good Great location. The staff is attentive comparing to other five stars hotels that I've stayed in Paris before. Room are pretty small but functional. Great view for my room but I wasn't expect loud music from the disco directly opposite the hotel property. Wish your staff should have addressed to hotel guests if they are facing the Opera. July 1, 2014
Rated 3 out of 5 by Guest73 Unfortunate Experience Unfortunately we were extremely disappointed with our experience at this hotel. We were there on vacation but were woken up every day at 7 am with major banging due to construction and refurbishment of the restaurant/bar at the hotel. It was a major problem that went on throughout the day. Rooms were not stocked properly with towel replacement, water, amenities. As an overall experience i would say it did not meet 5 * standards. June 29, 2014
Rated 5 out of 5 by Borannes Great Stay in Paris just a great place to stay in Paris. the hotel stand out from the crowd! June 27, 2014
Rated 5 out of 5 by JDCAR Fantastic! Great decoration, excellent service, perfect location. One of the best hotels I've been in Paris. All the staff is wonderful and very attentive. June 25, 2014
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Febrile seizures and behavioural and cognitive outcomes in preschool children: an old issue revisited
Version of Record online: 3 SEP 2012
DOI: 10.1111/j.1469-8749.2012.04413.x
© The Author. Developmental Medicine & Child Neurology © 2012 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 54, Issue 11, page 969, November 2012
Additional Information
How to Cite
DEONNA, T. (2012), Febrile seizures and behavioural and cognitive outcomes in preschool children: an old issue revisited. Developmental Medicine & Child Neurology, 54: 969. doi: 10.1111/j.1469-8749.2012.04413.x
Publication History
- Issue online: 5 OCT 2012
- Version of Record online: 3 SEP 2012
- Abstract
- Article
- References
- Cited By
The possible deleterious role of febrile seizures on development is an old issue. It took a long time to realize that impaired development or occurrence of chronic epilepsy affected a very small minority of children with febrile seizures. These children either had pre-existing brain damage, specific genetic epileptic conditions, or seizure-induced brain damage from repeated prolonged seizures. Population-based (and not hospital-based) large prospective studies of children with simple febrile seizures (a definition that is still debated) have quite unequivocally shown that these do not cause any brain injury.
Children with 'simple' febrile seizures do not differ from controls in intelligence and behaviour at school age1,2 and the large majority do not develop epilepsy.3 So why another study on this topic and are there new data challenging what most clinicians thought was a settled issue?
Visser et al.'s 4article comes from a large population-based cohort in which seizure data were assessed by questionnaires at the ages of 1, 2, and 3 years. They distinguished children with single versus recurrent febrile seizures, the latter defined as more than one single febrile seizure (number, focality, and duration of seizures were not studied). They found in both groups that social-behavioral development at 3 years (Child Behavior Checklist [CBCL]) and a comprehensive questionnaire on executive functions (Behavior Rating Inventory of Executive Function-Preschool Version [BRIEF-P]) at 4 years were not different from that of controls without seizures. These findings also applied to the 23 children whose first febrile seizure had occurred before the age of 1 year, contrary to some previous studies. All this is confirmatory good news.
However, there was one new finding in children with recurrent seizures. The authors found 'an increased risk of delayed vocabulary development' on the basis of the language questionnaire at 2.5 years (not checked at 4y). They concluded that 'children with recurrent febrile seizures might be at risk for delayed language development.' The authors proposed that some brain dysfunction related to the febrile seizure could occur, because their onset coincides with rapid language acquisition between 1 year and 3 years. Knowing the variability of language development, and especially expressive speech (here vocabulary at the age of 2.5y), the relevance of this statistical difference is questionable. It is more likely that children with recurrent febrile seizures and language delay are a heterogenous population with, among others, specific genetic conditions, or pre-existing brain pathology.
The results of this study do not challenge older data showing that febrile seizures do not have developmental consequences.
Nowadays, clinicians who see a child with a first seizure while febrile will integrate new data that have changed the old dichotomous vision of simple versus complex febrile seizures. This event is now regarded as having a much broader range of possible causes, mainly brain susceptibility due to different genes (e.g. SCN1A, SCN2A, PCDH19), a viral infection with propensity to seizures with fever (e.g. Rota-virus infection), or a symptomatic epilepsy with normal development. The clinical context will sometimes suggest specific epileptic syndromes such as infantile familial convulsions, Dravet syndrome, idiopathic partial epilepsies, or generalized or genetic epilepsy with febrile seizures plus (GEFS+). The latter (GEFS+) seems more frequent than initially thought and has most often a benign prognosis. An occasional afebrile seizure or a family history of epilepsy in close relatives in a child with otherwise simple febrile seizures is now looked at with this possibility in mind.
The rare cases with one or several severe recurrences (status) are now less frequent and better handled by the parents at home with rectal or oral short-acting diazepines (midazolam) with a decreased risk of seizure-induced brain damage. Much progress has been made since the time when prophylactic phenobarbital was proposed for children at the first or second febrile seizure. The spectrum of conditions under what seemed a simple genetic transitory childhood condition or epilepsy triggered by fever has been much enlarged.
- 1Prognosis in children with febrile seizures. Pediatrics 1978; 61: 720–7., .
- 2Long-term intellectual and behavioral outcomes of children with febrile convulsions. N Engl J Med 1998; 338: 1723–8., , .
- 3Long-term risk of developing epilepsy after febrile seizures: a prospective cohort study. Neurology 2012; 78: 1166–70., , , et al.
- 4Febrile seizures and cognitive outcomes in preschool children. the Generation R Study. Dev Med Child Neurol DOI: 10.1111/1469-8749.2012.04405.x. (Published online)., , , et al.


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OTTAWA — Two local youth golfers finished second Tuesday at the Lima
Junior Golf Association Union Bank Open at the Pike Run Golf Course.
PUTNAM COUNTY — There will be an Ohio High School Athletic Association
Volleyball Officiating class beginning in mid-July for Van Wert,
Paulding, Putnam, Mercer or Allen counties.
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< 1k
in the U.S.
since 1880
- Gender: Unknown
Pronunciation of Dingus
How popular is the name "Dingus" in the U.S.?
Out of 5,647,426 records in the U.S. Social Security Administration public data, the name "Dingus" was not present. It is possible the name you are searching has less than five occurrences per year. You might want to use a short version of your first name or perhaps your nickname.
On the other hand, you simply have a name that no one else in America is using. For 135 years only your parents have thought of using your name. Hoorah! You are a unique individual.
What does the name "Dingus" mean?
D is for dignity, no one disputes this trait!
I is for intense, your zest of living.
N is for noble, your regal bearing.
G is for golden, memories you share.
U is for uncanny, the way you know what to do.
S is for sensational, you know how to make a splash!
Your name in reverse order is "Sugnid". A random rearrangement of the letters in your name (anagram) will give "Ngusid". How do you pronounce that?
Now try the names of everyone you know including friends, cousins, neighbors, classmates, co-workers or your pets. Even your favorite anime, TV or movie characters! See what their names mean. Remember, this is purely just for fun.
Past life for Dingus born Mar 27, 1944
I do not know how you feel about it, but you were a male in your last earthly incarnation. You were born somewhere around the territory of Alaska approximately on 1175. Your profession was handicraftsman and mechanic.
You were a seeker of truth and wisdom. You could have seen your future lives. Others perceived you as an idealist illuminating path to the future. You fulfill your lesson by helping old folks and children. You came to that life to learn to care about weak and helpless.
Name poster for Dingus
(click to save the high quality version)
Here's something for you to ponder on...
What Does My Name Mean? - Have you wondered at one time or another what does my name mean? Knowing the meaning of your name can make you feel more amenable to your name than before.


text:
NYC Parks Events Calendar
Get up, get out, and do something! Just about any day of the year, you can find something fun, informative, and healthy to enjoy at an area park. Feel free to browse the listings below, or use the search tools to find an event that matches your interests and location.
Viewing 14,871–14,880 out of 17,253 events
from November 6, 2012 (x) to April 25, 2026
Friday, August 12, 2016
Summer Sports Experience at Playground for all Children, Queens
at Playground for All Children (in Flushing Meadows Corona Park), Queens
3:00 p.m.–5:00 p.m.
Join NYC Parks at the Playground for all Children Mondays- Fridays this summer to learn sports such as Wiffleball, Kickball, Ultimate Frisbee and Flag Football. All Levels appropriate.
Category: Best for Kids, Sports, Summer Sports Experience
Summer Sports Experience at Grandview Playground
at Grandview Playground (in The Big Park), Staten Island
3:00 p.m.–5:00 p.m.
The Summer Sports Experience provides a friendly introduction to sports for kids!
Category: Best for Kids, Sports, Summer Sports Experience
Summer Sounds: SKA Orchestra
at Lawrence Virgilio Playground, Queens
6:00 p.m.–7:00 p.m.
The NYC SKA Orchestra is an 18- piece big band with a bold new sound. The orchestra boasts a lush musical style of jazz, blues, ska, rock steady and reggae.
Category: Concerts, Free Summer Concerts
Game Social
at 40th Street Plaza (in Bryant Park), Manhattan
6:00 p.m.–8:00 p.m.
Make new friends and play some of the most exciting strategy board games at this social event.
Category: Games, Seniors
Hike and Draw
at Van Cortlandt Nature Center (in Van Cortlandt Park), Bronx
6:30 p.m.–7:30 p.m.
Focusing in on nature and transferring it to paper can be a calming and meditative process.
Category: Nature, Art, Hiking
Hip Hop Dance Aerobics
at The Granite Prospect (in Brooklyn Bridge Park), Brooklyn
7:00 p.m.–8:00 p.m.
This class teaches step by step movements with fun choreography, so you can get your feet moving and your heart pumping.
Category: Fitness, Outdoor Fitness
All the Park's A Stage: The Winter's Tale
at Bridge View Lawn (in Brooklyn Bridge Park), Brooklyn
7:00 p.m.–9:00 p.m.
See free performances of Shakespeare's romantic comedy The Winter's Tale by the New York Classical Theatre.
Category: Theater, Free Summer Theater, Shakespeare in the Parks
Family Camping: Staten Island
at Conference House Park, Staten Island
7:00 p.m.–7:00 a.m.
Camp overnight in Conference House Park with our Urban Park Rangers. We'll provide tents.
Category: Nature
Lola Star's Dreamland Roller Disco Party: Saturday Night Fever
at Lefrak Center at Lakeside (in Prospect Park), Brooklyn
7:30 p.m.–10:00 p.m.
Lola Star and her fabulous array of guests and performers will get you moving.
Category: Dance
Movies Under the Stars: Teenage Mutant Ninja Turtles
at Crocheron Park, Queens
8:00 p.m.–10:00 p.m.
Join NYC Parks and the New York City Mayor's Office of Media and Entertainment for a free film!
Category: Film, Free Summer Movies, Movies Under the Stars
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- Swimmer Ryan Lochte reveals one of his worst dates - US Weekly
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03 December 2012 at 10:16 PM
Taylor Swift & Dianna Agron: Ripple of Hope Gala 2012!
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I am having a mental block!!
is "Dear Sir" known as a salutation? I think this is what my css class will be called
Semantically speaking, should the salutation be a
por something else completely!
I'm leaning towards
span, but wondered if anyone else had a spare 2 cents.
Many thanks


text:
"Attractive as they are, these plants still strike fear into the hearts of even experienced gardeners. This book looks to change our view, showing us that with a little knowledge you can keep your plant not only happily in flower, but persuade it to bloom again and again. If you've resisted the world of orchids until now, The Orchid Expert would be worth investing in to ensure you begin on the right path. Who knows? It could be the start of a whole new hobby!" Garden News
"The clarity of the illustrations has always been your hallmark, and here we have it again, making everything simple instead of mysterious. What a clever fellow you are, but I knew that. It will cheer up a lot of people who have tried and failed. How astounding some of the less well known varieties are. They look like mad inventions, nature at its oddest." Dowager Duchess of Devonshire


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From Amazon
This highly readable translation of French historian Evelyne Lever's 1991 biography captures all the drama and pathos of Marie Antoinette's short life. Born in 1755, this carefree, fun-loving daughter of Austrian empress Maria Theresa inherited neither her mother's political shrewdness nor her sense of duty. She was married off at 14 to the stolid, clumsy French Dauphin, who would not fully consummate their marriage for another seven years, at which point he was King Louis XVI and their marital difficulties were the subject of public ridicule. She consoled herself by retreating to the artificial village she constructed at Trianon, where she could be free of the court etiquette she hated and indulge in expensive amusements that only increased her unpopularity. Her rare incursions into politics were just as ill judged; she alienated the French nobility with attempts to further Austria's diplomatic goals, and from the first rumblings of revolution in 1788, she influenced Louis to take a hard line on royal power when compromise might have saved the monarchy and prevented their executions in 1793. Lever does not soften Marie Antoinette's faults or downplay her poor judgment, but most readers will finish this absorbing narrative feeling very sorry for a pretty, goodhearted, but fundamentally frivolous woman thrown into a historical moment whose demands were beyond her. --Wendy Smith --This text refers to an out of print or unavailable edition of this title.
From Publishers Weekly
This romantic portrait of the queen who was reviledAand eventually executedAby the French revolutionaries transforms the woman who supposedly said "Let them eat cake" from a symbol of the cruelty of class politics into a quaint sovereign. Lever, a French historian who has written biographies of Madame de Pompadour and other figures of the French court, sees Marie Antoinette as a fashionable and frivolous victim of salacious rumors. While she admits that her subject had a "complete lack of insight into the aspirations of the majority of the French people," Lever portrays Antoinette as the novelistic heroine she always wanted to beAnot an actor on the political stage. Her "voluptuous bosom," "fleshy mouth" and "supple neck," Lever writes, were unspoiled by her "slightly protruding blue eyes," and she "knew better than any other sovereign how to bring to perfection the aristocratic art of living of prerevolutionary France." Although a compelling narrative, the book doesn't do justice to the weighty moral and political themes Marie Antoinette's life and death raise. The queen, it is clear, was a political disaster, managing to alienate both a sizeable section of the courtly aristocracy and the starving masses. Her extravagance and counter-revolutionary impulses provoked "incredibly venomous" lampoons (and, of course, her death). But Lever never takes up these components of her life. Rather, she repeatedly ascribes acts of revolutionary violence to "madness" perpetrated by "madmen." Energetically researched in Paris, Vienna, even Sweden (the home of the queen's dark, handsome beau, who also "looked exactly like the hero of a novel"), the book is evocative, but romance, rather than historical analysis, takes precedence here. 8 pages of b&w photos not seen by PW. (July)
Copyright 2000 Reed Business Information, Inc. --This text refers to an out of print or unavailable edition of this title.
Customer Reviews
Top Customer Reviews
Marie Antoinette was not in herself a terribly interesting person. Her life reads like the life of any celebrity, surrounded by lovers, sycophants who enjoyed a fabulous lifestyle. Marie ensconced herself at The Trianon, dispensing with court dress and court manners to live a luxurious and peaceful life. Sadly, the ferment of the French Revolution swirled around this somewhat simple queen, and she paid a price that must have, in the end, surprised her. The story of their belated attempt to escape France, and the indifference of other crowned heads of Europe (relatives) to their plight is pathetic.
This biography is dry at times--perhaps due to the fact that it's the surrounding history, persons and events that make Marie Antoinette interesting, not the queen in herself.
The book reads like a soap opera, without too much emphasis on the political background of Marie Antoinette and Louis the Sixteenth, and more emphasis on the dirty little details of their private lives. However, there seemed to be too much repetition involved in discussing the Queen's affair with Swedish count Axel Fersen, and in these points, the book could become dry and only worth skimming. I also found myself confused at the switching of names between Princess Marie Therese and Madame Royale from chapter to chapter, when they were in fact the same person.
The ending was beautiful, sophisticated, and simple. I appreciated the epilogue, because I found myself interested in what happened to the (few) survivors of the French Revolution. The cover was well done also, and is a beautiful work overall. I would definitely recommend this book to anyone interested in a biography about scandalous royalty. :)
Most recent customer reviews
Très bon livre sur Marie-Antoinette; sa personnalité, les derniers jours avant la Révolution Française. Read morePublished on Sept. 29 2005
While the book itself isn't bad, in fact it's informative, the problem is that it's somewhat informative, it's missing a few details, and it seems that the author of the book... Read morePublished on Feb. 23 2004 by Cindy Y. Araya
The reader who claims the title is wrong DOES NOT KNOW French History. Marie Antoinette, Reine de France et Navarre WAS THE LAST Queen of France. Read morePublished on Aug. 30 2001 by L. Henderson
The reader who claims the title is wrong DOES NOT KNOW French History. Marie Antoinette, Reine de France et Navarre WAS THE LAST Queen of France. Read morePublished on Aug. 30 2001 by L. Henderson
One cannot believe much in a book with an incorrect title. Marie Antoinette was not the last queen of France. Read morePublished on July 30 2001 by martin chapman
This is truly strange! The French edtion has 733 pages and this English version is clearly truncated. Why? Read morePublished on April 8 2001
My curiousity about Marie-Antoinette and her life first came about in high school, when my French teacher would tell us about the French queen's "Petit Trianon" and her... Read morePublished on March 13 2001
A very good biography of Marie Antoinette, which mixes both the politics of the time along with the many mistakes made by Marie Antoinette. Read morePublished on Nov. 27 2000 by Dana Keish


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