text:
|Publication number
|Publication type
|Application number
|Publication date
|Apr 19, 2011
|Filing date
|Mar 28, 2006
|Priority date
|Aug 20, 2001
|Fee status
|Also published as
|Publication number
|Stephen Hunter Diaz, Theodore L. Parker
|Original Assignee
|Innovational Holdings, Llc
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (16), Non-Patent Citations (2), Referenced by (1), Classifications (14), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims priority to U.S. Provisional Patent Application Ser. No. 60/667,564, filed Mar. 31, 2005. This application also claims priority to U.S. patent application Ser. No. 09/948,989, filed Sep. 7, 2001, which claims priority to U.S. Provisional Patent Application Ser. No. 60/314,25, filed Aug. 20, 2001. The entire contents of both are incorporated herein by reference.
The invention relates to a method and apparatus for loading a beneficial agent, such as a drug into a medical device, such as a stent.
Implantable medical devices are often used for delivery of a beneficial agent, such as a drug, to an organ or tissue in the body at a controlled delivery rate over an extended period of time. These devices may deliver agents to a wide variety of bodily systems to provide a wide variety of treatments.
One of the many implantable medical devices which have been used for local delivery of beneficial agents is the coronary stent. Coronary stents are typically introduced percutaneously, and transported transluminally until positioned at a desired location. These devices are then expanded either mechanically, such as by the expansion of a mandrel or balloon positioned inside the device, or expand themselves by releasing stored energy upon actuation within the body. Once expanded within the lumen, these devices, called stents, become encapsulated within the body tissue and remain a permanent implant.
Known stent designs include monofilament wire coil stents (U.S. Pat. No. 4,969,458); welded metal cages (U.S. Pat. Nos. 4,733,665 and 4,776,337); and, most prominently, thin-walled metal cylinders with axial slots formed around the circumference (U.S. Pat. Nos. 4,733,665; 4,739,762; and 4,776,337). Known construction materials for use in stents include polymers, organic fabrics and biocompatible metals, such as stainless steel, gold, silver, tantalum, titanium, and shape memory alloys, such as Nitinol, and biodegradable materials including biodegradable polymers and biodegradable metal alloys.
Of the many problems that may be addressed through stent-based local delivery of beneficial agents, one of the most important is restenosis. Restenosis is a major complication that can arise following vascular interventions such as angioplasty and the implantation of stents. Simply defined, restenosis is a wound healing process that reduces the vessel lumen diameter by extracellular matrix deposition, neointimal hyperplasia, and vascular smooth muscle cell proliferation, and which may ultimately result in renarrowing or even reocclusion of the lumen. Despite the introduction of improved surgical techniques, devices, and pharmaceutical agents, the overall restenosis rates for bare metal stents are still reported in the range of 10% to 25% within six to twelve months after an angioplasty procedure. To treat this condition, additional revascularization procedures are frequently required, thereby increasing trauma and risk to the patient.
One of the techniques recently introduced to address the problem of restenosis is the use of surface coatings of various drugs on stents. Surface coatings, however, can provide little actual control over the release kinetics of beneficial agents. These coatings are necessarily very thin, typically 5 to 8 microns deep. The surface area of the stent, by comparison is very large, so that the entire volume of the beneficial agent has a very short diffusion path to discharge into the surrounding tissue.
Increasing the thickness of the surface coating has the beneficial effects of improving drug release kinetics including the ability to control drug release and to allow increased drug loading. However, the increased coating thickness results in increased overall thickness of the stent wall and increased risk of cracking, flaking, or separating from the stent.
In addition, it is not currently possible to deliver many drugs with a surface coating due to sensitivity of the drugs to water, other compounds, or conditions in the body which degrade the drugs. Lack of drug capacity and lack of control over delivery also limit the usefulness of surface coatings for many drugs.
U.S. Patent Publication 2004/0073294 describes systems and methods for loading a beneficial agent into holes in a medical device, such as a stent. This process uses a computer guided micro dispenser to load droplets of liquid solution into the holes of the stent. The stents are mounted on a rubber coated mandrel blocking the bottoms of the holes. A machine, using machine vision, maps the exact locations of each of the target holes and then moves each hole under the dispenser that then shoots liquid into the holes. The filled stent is dried in an oven, and then a next deposit is applied. Subsequent deposits of polymer and polymer/drug are applied to achieve the desired release properties.
This process has some advantages. It is a non-contact process, so there is little drag of material from hole to hole and no back contamination. It is very fast, filling at least 10 holes per second. The dispenser can be turned on and off very quickly, so complex patterns of filling can be supported. It has proven results of accuracy and consistency.
The liquid droplet method also has some limitations. The piezoelectric dispenser generally requires solutions with low viscosities. Therefore, the solids content should remain low, often less than 5%. The low solids content can result in the need for many deposits to build up a sufficient amount of beneficial agent. In addition, the solid should be very soluble in the solvent. This may require the use of solvents that have undesirable properties. Finally, the oven drying step is too hot for some drugs or proteins.
Accordingly, it would be desirable to provide a system and method for loading a beneficial agent into an expandable medical device, such as a stent, which can deliver compositions with higher solids content and/or can operate with limited drying time or low drying temperature.
The present invention relates to a system and method for loading a beneficial agent in a medical device wherein the beneficial agent is in the form of particles.
In accordance with one aspect of the invention, a method for loading a medical device with a beneficial agent comprises the steps of providing a medical device with a plurality of holes, delivering a plurality of particles of drug into the plurality of holes in a dry form, and delivering a liquefying substance into the plurality of holes. The liquefying substance liquefies at least a portion of the particles and adheres the drug in the holes.
In accordance with another aspect of the invention, a method for loading a medical device with a beneficial agent comprises the steps of providing a medical device with a plurality of holes, forming a plurality of particles comprising a beneficial agent, delivering the plurality of particles into the plurality of holes, and securing the particles in the holes. The particles are sized to fit as a plug with a single particle in each of the plurality of holes.
In accordance with a further aspect of the invention, a system for loading a medical device with a beneficial agent is comprised of a particle delivery system for delivery of particles of drug into a plurality of holes in a medical device and a solvent delivery system for delivery of a liquid solvent into the plurality of holes in the medical device.
The invention will now be described in greater detail with reference to the preferred embodiments illustrated in the accompanying drawings, in which like elements bear like reference numerals.
The present invention relates to a method and apparatus for loading a beneficial agent into a medical device. More particularly, the invention relates to a method and apparatus for loading a beneficial agent in a stent.
First, the following terms, as used herein, shall have the following meanings:
The term "beneficial agent" as used herein is intended to have its broadest possible interpretation and is used to include any therapeutic agent or drug, as well as inactive agents such as barrier layers, carrier layers, therapeutic layers or protective layers.
The terms "drug" and "therapeutic agent" are used interchangeably to refer to any therapeutically active substance that is delivered to a living being to produce a desired, usually beneficial, effect. The present invention is particularly well suited for the delivery of antineoplastic, angiogenic factors, immuno-suppressants, anti-inflammatories and antiproliferatives (anti-restenosis agents) such as paclitaxel and Rapamycin for example, and antithrombins such as heparin, for example.
The term "matrix" or "biocompatible matrix" are used interchangeably to refer to a medium or material that, upon implantation in a subject, does not elicit a detrimental response sufficient to result in the rejection of the matrix. The matrix typically does not provide any therapeutic responses itself, though the matrix may contain or surround a therapeutic agent, a therapeutic agent, an activating agent or a deactivating agent, as defined herein. A matrix is also a medium that may simply provide support, structural integrity or structural barriers. The matrix may be polymeric, non-polymeric, hydrophobic, hydrophilic, lipophilic, amphiphilic, and the like.
The term "bioresorbable" refers to a matrix, as defined herein, that can be broken down by either chemical or physical process, upon interaction with a physiological environment. The bioresorbable matrix is broken into components that are metabolizable or excretable, over a period of time from minutes to years, preferably less than one year, while maintaining any requisite structural integrity in that same time period.
The term "polymer" refers to molecules formed from the chemical union of two or more repeating units, called monomers. Accordingly, included within the term "polymer" may be, for example, dimers, trimers and oligomers. The polymer may be synthetic, naturally-occurring or semisynthetic. In preferred form, the term "polymer" refers to molecules which typically have a Mw greater than about 3000 and preferably greater than about 10,000 and a Mw that is less than about 10 million, preferably less than about a million and more preferably less than about 200,000.
The term "holes" refers to holes of any shape and includes both through-holes and recesses.
Implantable Medical Devices with Holes
U.S. Pat. No. 6,241,762 illustrates a medical device in the form of a stent designed with large, non-deforming struts, which can contain holes without compromising the mechanical properties of the struts, or the device as a whole. The non-deforming struts can be achieved by the use of ductile hinges which are described in detail in U.S. Pat. No. 6,241,762, which is incorporated hereby by reference in its entirety. The holes serve as large, protected reservoirs for delivering various beneficial agents to the device implantation site.
The holes can be circular, oval, rectangular, polygonal, D-shaped, or other shaped and can extend through the thickness of the medical device. The volume of beneficial agent that can be delivered using holes is about 3 to 10 times greater than the volume of a 5 micron coating covering a stent with the same stent/vessel wall coverage ratio. This much larger beneficial agent capacity provides several advantages. The larger capacity can be used to deliver multi-drug combinations, each with independent release profiles, for improved efficacy. Also, larger capacity can be used to provide larger quantities of less aggressive drugs to achieve clinical efficacy without the undesirable side-effects of more potent drugs.
According to one example, the total depth of the holes is about 100 to about 140 microns (about 0.0039 to about 0.0055 inches), typically 125 microns (0.0049 inches) for stainless steel. For stronger alloys, such as commercially available cobalt chromium alloys, the stent may be somewhat thinner. For example, the total depth of the holes is about 60 to about 100 microns (about 0.0026 to about 0.0039 inches) for cobalt chromium alloys. According to one preferred embodiment of the present invention, each of the holes have an area of at least 5�10−6 square inches, and preferably at least 10�10−6 square inches. A square hole having a width of about 0.005 inches will have an hole area of about 25�10−6 square inches.
Uses for Implantable Medical Devices
Although the present invention has been described with reference to a medical device in the form of a stent, the medical devices of the present invention can also be medical devices of other shapes useful for site-specific and time-release delivery of drugs to the body including the heart and other organs and tissues. The drugs may be delivered to the vasculature including the coronary and peripheral vessels for a variety of therapies, and to other lumens in the body. The drugs may increase lumen diameter, create occlusions, or deliver the drug for other reasons. The medical devices can take a variety of shapes including cylinders, spheres, coils, filament, mesh, and other shapes.
Medical devices and stents, as described herein, are useful for the prevention of amelioration of restenosis, particularly after percutaneous transluminal coronary angioplasty and intraluminal stent placement. In addition to the timed or sustained release of anti-restenosis agents, other agents such as anti-inflammatory agents may be incorporated into the microstructures incorporated in the plurality of holes within the device. This allows for site-specific treatment or prevention any complications routinely associated with stent placements that are known to occur at very specific times after the placement occurs.
Systems and Methods for Loading a Beneficial Agent into a Medical Device
The beneficial agent is applied into the holes in a medical device in a dry particulate form and is adhered in the hole in a manner that allows release of the drug in a controlled manner.
According to a first embodiment, a machine very similar to the dropwise filling machine described in U.S. Patent Publication 2004/0073294, which is incorporated herein by reference in its entirety, is used to deliver a slow drying solvent into the holes in a dropwise manner. Alternatively, the slow drying solvent can be delivered into the holes in other manners. The hole should only be partially filled with solvent, for example, the solvent can fill about 10% to about 80% of the hole.
The drug material would be formed into particles 10 and placed in the holes as shown in
In one example shown in
Alternately, the spheres or particles can be sized smaller so that a plurality of spheres or particles fit in each hole. The particles can be dropped, shot, or sprayed out of a tube that is positioned over the hole. This can be performed with a computer controlled jetting device, such as a piezoelectric microjet. In another embodiment of
The release kinetics of the microstructure created within the holes can be modified by using multi-layer spheres with the layers having different compositions to control the release. For example, a sphere with a central drug/polymer core can be surrounded by a polymer only layer with can form a barrier layer to control delivery of the drug.
As an alternative to depositing the particles in the holes by a controlled jetting process, the holes can be loaded with particles by dipping. For example, a mandrel having one or more stents with solvent filled holes can be immersed in an ocean of particles or spheres, such as in a fluidized bed. The particles that contacted the solvent at the bottom of the holes will stick there, and the others will fall off.
Yet another method of applying the particles is to use an electrostatic spraying method to apply the particles into the holes. The mandrel can be charged and the charged particles can be sprayed onto the stents. The sprayed spheres will stick all over the stents, but only the spheres falling into the holes will be bonded in place on the stent by the liquefying agent or solvent within the holes.
In an alternative embodiment, the process is reversed and the spheres are applied first. When the holes are slightly square or tapered (as they naturally are due to the laser cutting process), and if the spheres are just the right size, then they can be placed or wedged in the holes, but nowhere else on the stent. If the right combination of size distributions is achieved, and if the spheres are shot at the stent with some velocity, every hole will have a sphere stuck in it, perhaps with the aid of a static charge. After blowing or brushing off the excess spheres, the entire mandrel can be sprayed with solvent to soften the spheres lodged in the holes to force them to stick in place. Alternately, the solvent can be shot dropwise into the individual holes after filling them with spheres, as before.
Other particles including a simple powder or chopped fiber can be used as an alternative to the spheres. The concept with powder or other particles remains the same as with the spheres. Selective adhesion of the drug or drug/polymer matrix in the hole combined with a solvent or weak solution applied before or after application of the particles allows the drug or drug/polymer material to be permanently affixed in the holes.
In one embodiment, the particles and liquefying agents delivered into the holes can be loaded sequentially in layers with different compositions or concentrations in the layers. Different layers can be comprised of different therapeutic agents altogether, creating the ability to release different therapeutic agents at different points in time. The layers of beneficial agent provide the ability to tailor a drug delivery profile to different applications. This allows the medical device according to the present invention to be used for delivery of different beneficial agents to a wide variety of locations in the body.
A protective layer in the form of a cap layer can be provided at a tissue contacting surface of the stent. The cap layer can block or retard biodegradation of subsequent layers and/or block or retard diffusion of the beneficial agent in that direction for a period of time which allows the delivery of the medical device to a desired location in the body.
A barrier or base layer can also be used on the luminal (or mural) surface of the stent to achieve directional delivery of the therapeutic agent. The barrier or base layer can prevent the therapeutic agent from passing into the lumen and being carried away in the blood stream.
Other therapeutic agents for use with the present invention may, for example, take the form of small molecules, peptides, lipoproteins, polypeptides, polynucleotides encoding polypeptides, lipids, protein-drugs, protein conjugate drugs, enzymes, oligonucleotides and their derivatives, ribozymes, other genetic material, cells, antisense oligonucleotides, monoclonal antibodies, platelets, prions, viruses, bacteria, eukaryotic cells such as endothelial cells, stem cells, ACE inhibitors, monocyte/macrophages and vascular smooth muscle cells. Such agents can be used alone or in various combinations with one another. For instance, anti-inflammatories may be used in combination with antiproliferatives to mitigate the reaction of tissue to the antiproliferative. The therapeutic agent may also be a pro-drug, which metabolizes into the desired drug when administered to a host. In addition, therapeutic agents may be pre-formulated as microcapsules, microspheres, microbubbles, liposomes, niosomes, emulsions, dispersions or the like before they are incorporated into the matrix. Therapeutic agents may also be radioactive isotopes or agents activated by some other form of energy such as light or ultrasonic energy, or by other circulating molecules that can be systemically administered.
Exemplary classes of therapeutic agents include antiproliferatives, antithrombins (i.e., thrombolytics), immunosuppressants, antilipid agents, anti-inflammatory agents, antineoplastics including antimetabolites, antiplatelets, angiogenic agents, anti-angiogenic agents, vitamins, antimitotics, metalloproteinase inhibitors, NO donors, nitric oxide release stimulators, anti-sclerosing agents, vasoactive agents, endothelial growth factors, beta blockers, AZ blockers, hormones, statins, insulin growth factors, antioxidants, membrane stabilizing agents, calcium antagonists (i.e., calcium channel antagonists), retinoids, anti-macrophage substances, antilymphocytes, cyclooxygenase inhibitors, immunomodulatory agents, angiotensin converting enzyme (ACE) inhibitors, anti-leukocytes, high-density lipoproteins (HDL) and derivatives, cell sensitizers to insulin, prostaglandins and derivatives, anti-TNF compounds, hypertension drugs, protein kinases, antisense oligonucleotides, cardio protectants, petidose inhibitors (increase blycolitic metabolism), endothelin receptor agonists, interleukin-6 antagonists, anti-restenotics, vasodilators, and other miscellaneous compounds.
Antiproliferatives include, without limitation, paclitaxel, actinomycin D, rapamycin, everolimus, ZoMaxx, tacrolimus, cyclosporin, and pimecrolimus.
Antithrombins include, without limitation, heparin, aspirin, sulfinpyrazone, ticlopidine, ABCIXIMAB, eptifibatide, tirofiban HCL, coumarines, plasminogen, α2-antiplasmin, streptokinase, urokinase, bivalirudin, tissue plasminogen activator (t-PA), hirudins, hirulogs, argatroban, hydroxychloroquin, BL-3459, pyridinolcarbamate, Angiomax, and dipyridamole.
Immunosuppressants include, without limitation, cyclosporine, rapamycin and tacrolimus (FK-506), ZoMaxx, everolimus, etoposide, and mitoxantrone.
Antilipid agents include, without limitation, HMG CoA reductase inhibitors, nicotinic acid, probucol, and fibric acid derivatives (e.g., clofibrate, gemfibrozil, gemfibrozil, fenofibrate, ciprofibrate, and bezafibrate).
Anti-inflammatory agents include, without limitation, pimecrolimus, salicylic acid derivatives (e.g., aspirin, insulin, sodium salicylate, choline magnesium trisalicylate, salsalate, dflunisal, salicylsalicylic acid, sulfasalazine, and olsalazine), para-amino phenol derivatives (e.g., acetaminophen), indole and indene acetic acids (e.g., indomethacin, sulindac, and etodolac), heteroaryl acetic acids (e.g., tolmetin, diclofenac, and ketorolac), arylpropionic acids (e.g., ibuprofen, naproxen, flurbiprofen, ketoprofen, fenoprofen, and oxaprozin), anthranilic acids (e.g., mefenamic acid and meclofenamic acid), enolic acids (e.g., piroxicam, tenoxicam, phenylbutazone and oxyphenthatrazone), alkanones (e.g., nabumetone), glucocorticoids (e.g., dexamethaxone, prednisolone, and triamcinolone), pirfenidone, and tranilast.
Antineoplastics include, without limitation, nitrogen mustards (e.g., mechlorethamine, cyclophosphamide, ifosfamide, melphalan, and chlorambucil), methylnitrosoureas (e.g., streptozocin), 2-chloroethylnitrosoureas (e.g., carmustine, lomustine, semustine, and chlorozotocin), alkanesulfonic acids (e.g., busulfan), ethylenimines and methylmelamines (e.g., triethylenemelamine, thiotepa and altretamine), triazines (e.g., dacarbazine), folic acid analogs (e.g., methotrexate), pyrimidine analogs (5-fluorouracil, 5-fluorodeoxyuridine, 5-fluorodeoxyuridine monophosphate, cytosine arabinoside, 5-azacytidine, and 2′,2′-difluorodeoxycytidine), purine analogs (e.g., mercaptopurine, thioguanine, azathioprine, adenosine, pentostatin, cladribine, and erythrohydroxynonyladenine), antimitotic drugs (e.g., vinblastine, vincristine, vindesine, vinorelbine, paclitaxel, docetaxel, epipodophyllotoxins, dactinomycin, daunorubicin, doxorubicin, idarubicin, epirubicin, mitoxantrone, bleomycins, plicamycin and mitomycin), phenoxodiol, etoposide, and platinum coordination complexes (e.g., cisplatin and carboplatin).
Antiplatelets include, without limitation, insulin, dipyridamole, tirofiban, eptifibatide, abciximab, and ticlopidine.
Angiogenic agents include, without limitation, phospholipids, ceramides, cerebrosides, neutral lipids, triglycerides, diglycerides, monoglycerides lecithin, sphingosides, angiotensin fragments, nicotine, pyruvate thiolesters, glycerol-pyruvate esters, dihydoxyacetone-pyruvate esters and monobutyrin.
Anti-angiogenic agents include, without limitation, endostatin, angiostatin, fumagillin and ovalicin.
Vitamins include, without limitation, water-soluble vitamins (e.g., thiamin, nicotinic acid, pyridoxine, and ascorbic acid) and fat-soluble vitamins (e.g., retinal, retinoic acid, retinaldehyde, phytonadione, menaqinone, menadione, and alpha tocopherol).
Antimitotics include, without limitation, vinblastine, vincristine, vindesine, vinorelbine, paclitaxel, docetaxel, epipodophyllotoxins, dactinomycin, daunorubicin, doxorubicin, idarubicin, epirubicin, mitoxantrone, bleomycins, plicamycin and mitomycin.
Metalloproteinase inhibitors include, without limitation, TIMP-1, TIMP-2, TIMP-3, and SmaPI.
NO donors include, without limitation, L-arginine, amyl nitrite, glyceryl trinitrate, sodium nitroprusside, molsidomine, diazeniumdiolates, S-nitrosothiols, and mesoionic oxatriazole derivatives.
NO release stimulators include, without limitation, adenosine.
Anti-sclerosing agents include, without limitation, collagenases and halofuginone.
Vasoactive agents include, without limitation, nitric oxide, adenosine, nitroglycerine, sodium nitroprusside, hydralazine, phentolamine, methoxamine, metaraminol, ephedrine, trapadil, dipyridamole, vasoactive intestinal polypeptides (VIP), arginine, and vasopressin.
Endothelial growth factors include, without limitation, VEGF (Vascular Endothelial Growth Factor) including VEGF-121 and VEG-165, FGF (Fibroblast Growth Factor) including FGF-1 and FGF-2, HGF (Hepatocyte Growth Factor), and Ang1 (Angiopoietin 1).
Beta blockers include, without limitation, propranolol, nadolol, timolol, pindolol, labetalol, metoprolol, atenolol, esmolol, and acebutolol.
Hormones include, without limitation, progestin, insulin, the estrogens and estradiols (e.g., estradiol, estradiol valerate, estradiol cypionate, ethinyl estradiol, mestranol, quinestrol, estrond, estrone sulfate, and equilin).
Statins include, without limitation, mevastatin, lovastatin, simvastatin, pravastatin, atorvastatin, and fluvastatin.
Insulin growth factors include, without limitation, IGF-1 and IGF-2.
Antioxidants include, without limitation, vitamin A, carotenoids and vitamin E.
Membrane stabilizing agents include, without limitation, certain beta blockers such as propranolol, acebutolol, labetalol, oxprenolol, pindolol and alprenolol.
Calcium antagonists include, without limitation, amlodipine, bepridil, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine and verapamil.
Retinoids include, without limitation, all-trans-retinol, all-trans-14-hydroxyretroretinol, all-trans-retinaldehyde, all-trans-retinoic acid, all-trans-3,4-didehydroretinoic acid, 9-cis-retinoic acid, 11-cis-retinal, 13-cis-retinal, and 13-cis-retinoic acid.
Anti-macrophage substances include, without limitation, NO donors.
Anti-leukocytes include, without limitation, 2-CdA, IL-1 inhibitors, anti-CD116/CD18 monoclonal antibodies, monoclonal antibodies to VCAM, monoclonal antibodies to ICAM, and zinc protoporphyrin.
Cyclooxygenase inhibitors include, without limitation, Cox-1 inhibitors and Cox-2 inhibitors (e.g., CELEBREX� and VIOXX�).
Immunomodulatory agents include, without limitation, immunosuppressants (see above) and immunostimulants (e.g., levamisole, isoprinosine, Interferon alpha, and Interleukin-2).
ACE inhibitors include, without limitation, benazepril, captopril, enalapril, fosinopril sodium, lisinopril, quinapril, ramipril, spirapril, and 2B3 ACE inhibitors.
Cell sensitizers to insulin include, without limitation, glitazones, P PAR agonists and metformin.
Antisense oligonucleotides include, without limitation, resten-NG.
Cardio protectants include, without limitation, VIP, pituitary adenylate cyclase-activating peptide (PACAP), apoA-I milano, amlodipine, nicorandil, cilostaxone, and thienopyridine.
Petidose inhibitors include, without limitation, omnipatrilat.
Anti-restenotics include, without limitation, include vincristine, vinblastine, actinomycin, epothilone, paclitaxel, paclitaxel derivatives (e.g., docetaxel), rapamycin, rapamycin derivatives, everolimus, tacrolimus, ZoMaxx, and pimecrolimus.
PPAR gamma agonists include, without limitation, farglitizar, rosiglitazone, muraglitazar, pioglitazone, troglitazone, and balaglitazone.
Miscellaneous compounds include, without limitation, Adiponectin.
Agents may also be delivered using a gene therapy-based approach in combination with an expandable medical device. Gene therapy refers to the delivery of exogenous genes to a cell or tissue, thereby causing target cells to express the exogenous gene product. Genes are typically delivered by either mechanical or vector-mediated methods.
Some of the agents described herein may be combined with additives which preserve their activity. For example additives including surfactants, antacids, antioxidants, and detergents may be used to minimize denaturation and aggregation of a protein drug. Anionic, cationic, or nonionic detergents may be used. Examples of nonionic additives include but are not limited to sugars including sorbitol, sucrose, trehalose; dextrans including dextran, carboxy methyl (CM) dextran, diethylamino ethyl (DEAE) dextran; sugar derivatives including D-glucosaminic acid, and D-glucose diethyl mercaptal; synthetic polyethers including polyethylene glycol (PEF and PEO) and polyvinyl pyrrolidone (PVP); carboxylic acids including D-lactic acid, glycolic acid, and propionic acid; detergents with affinity for hydrophobic interfaces including n-dodecyl-β-D-maltoside, n-octyl-β-D-glucoside, PEO-fatty acid esters (e.g. stearate (myrj 59) or oleate), PEO-sorbitan-fatty acid esters (e.g. Tween 80, PEO-20 sorbitan monooleate), sorbitan-fatty acid esters (e.g. SPAN 60, sorbitan monostearate), PEO-glyceryl-fatty acid esters; glyceryl fatty acid esters (e.g. glyceryl monostearate), PEO-hydrocarbon-ethers (e.g. PEO-10 oleyl ether; triton X-100; and Lubrol. Examples of ionic detergents include but are not limited to fatty acid salts including calcium stearate, magnesium stearate, and zinc stearate; phospholipids including lecithin and phosphatidyl choline; CM-PEG; cholic acid; sodium dodecyl sulfate (SDS); docusate (AOT); and taumocholic acid.
While the invention has been described in detail with reference to the preferred embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made and equivalents employed, without departing from the present invention.
|Cited Patent
|Filing date
|Publication date
|Nov 7, 1985
|Mar 29, 1988
|Expandable Grafts Partnership
|Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
|Nov 3, 1986
|Apr 26, 1988
|Expandable Grafts Partnership
|Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
|Jun 26, 1986
|Oct 11, 1988
|Expandable Grafts Partnership
|Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
|Jul 6, 1987
|Nov 13, 1990
|Medtronic, Inc.
|Intracoronary stent and method of simultaneous angioplasty and stent implant
|Oct 29, 1998
|Jun 5, 2001
|Conor Medsystems, Inc.
|Expandable medical device with ductile hinges
|Oct 26, 2000
|May 6, 2003
|Advanced Cardiovascular Systems, Inc.
|Method for etching a micropatterned microdepot prosthesis
|Dec 27, 2000
|Jul 5, 2005
|Advanced Cardiovascular Systems, Inc.
|Method for creating a textured surface on an implantable medical device
|Sep 15, 2003
|Jul 12, 2005
|Labcoat, Ltd.
|Stent coating device
|Oct 15, 2001
|May 1, 2003
|Regents Of The University Of Minnesota
|Candida albicans gene, integrin-like protein, antibodies, and methods of use
|May 28, 2003
|Apr 15, 2004
|Conor Medsystems, Inc.
|Method and apparatus for loading a beneficial agent into an expandable medical device
|May 19, 2003
|Nov 25, 2004
|Stenzel Eric B.
|Electrostatic coating of a device
|Jun 18, 2004
|Dec 2, 2004
|Diaz Stephen Hunter
|Method and apparatus for loading a benefical agent into an expandable medical device
|Jul 22, 2004
|Mar 10, 2005
|Medtronic Vascular, Inc.
|Stent with outer slough coating
|Feb 4, 2005
|Sep 22, 2005
|Maria Curcio
|Stent for endoluminal delivery of active principles or agents
|Jan 8, 2002
|Nov 26, 2009
|Translumina Gmbh
|Sep 5, 2001
|Apr 4, 2002
|Advanced Cardiovascular Systems, Inc.
|A method of loading a substance onto an implantable device
|Australian Office Action dated Aug. 10, 2010 for Australian Application No. 2006230204.
|European Search Report dated Jun. 1, 2010 for European Application No. 06739863.6.
|Citing Patent
|Filing date
|Publication date
|Feb 14, 2012
|Jun 14, 2012
|Boston Scientific Scimed, Inc.
|Bioerodible endoprosthesis with biostable inorganic layers
|U.S. Classification
|427/2.1, 427/180, 427/2.25, 427/331, 427/189, 427/2.24, 427/335
|International Classification
|Cooperative Classification
|European Classification
|May 8, 2007
Owner name: INNOVATIONAL HOLDINGS LLC, NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CONOR MEDSYSTEMS, INC.;REEL/FRAME:019955/0487
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Owner name: INNOVATIONAL HOLDINGS LLC,NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CONOR MEDSYSTEMS, INC.;REEL/FRAME:019955/0487
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|Nov 18, 2009
Owner name: INNOVATIONAL HOLDINGS LLC, NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CONOR MEDSYSTEMS, INC.;REEL/FRAME:023538/0021
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Effective date: 20070306
|Nov 28, 2014
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|Apr 19, 2015
|Lapse for failure to pay maintenance fees
|Jun 9, 2015
|Expired due to failure to pay maintenance fee
Effective date: 20150419


text:
The policy debate surrounding climate change intensified in 2009, particularly at the end of the year. The U.S. took an active role in the Copenhagen climate negotiations. Senator Cantwell introduced legislation that would cap greenhouse gases (GHG) and return revenues from the program back to U.S. citizens. Senators Kerry, Lieberman and Graham proposed a framework outlining principles for a comprehensive approach to climate and energy legislation. The EPA issued its endangerment finding determining that current and projected greenhouse gas concentrations in the atmosphere threaten public health and welfare, and the list goes on.
As many of you know, Ford has been one of the more supportive companies on climate policy for some time. In 1999 we kicked off our first corporate environmental report where we discussed greenhouse gases. In late 2005, we published a special report on the Business Impacts of Climate Change and in 2007 we joined the United States Climate Action Partnership (USCAP) to support the prompt enactment of climate legislation. As an automaker, engaging on climate change is important, because fuel economy and CO2 emissions are one and the same. In vehicles, the less petroleum you use, the less CO2 is emitted into the atmosphere.
Regulations governing vehicle fuel economy and emissions have been around since the 1970s. Last year the Administration reached an agreement establishing a single national program for vehicle fuel economy and GHG emissions through 2016. Ford supported the One National Program and is encouraging measures to ensure that this inclusive national approach for vehicle fuel economy and GHG emissions continues beyond 2016.
This experience, as well our activity in carbon markets globally, has helped to shape Ford's position on climate policy - we believe we need a national, market-based approach to reducing GHG emissions if the U.S. is going to reduce emissions at the lowest cost per ton. Thus, we support the creation of an efficient, economy-wide cap-and-trade framework with mechanisms to avoid unintended adverse effects on the economy. An economy-wide cap-and-trade program would provide flexibility to regulated entities while allowing market mechanisms to determine where GHG reductions can be achieved at the lowest cost. The environment doesn't care where reductions occur, but the economy does and given the potentially high cost of abatement, it is important to achieve the lowest cost possible.
Ford has been criticized for taking this position. On one side of the argument, some stakeholders do not think Ford should be supporting climate legislation and question our membership in groups like USCAP. To those we say that without a cohesive national energy and climate policy that places a price on carbon, we could be caught in a cycle of starting and stopping technology development. That is simply not good policy or good business, particularly when the technology development requires billions of dollars of investment.
On the other side are stakeholders who urge Ford to be more aggressive and want us to drop out of groups like the U.S. Chamber of Commerce which may have views and actions on climate change that potentially conflict with Ford's position. To them we say that despite differences on this specific issue, Ford has not changed our position on climate change.
It should be noted that the Chamber has been a critical ally on a broad range of other business and environmental issues important to Ford and the global auto industry, including the One National Program, vehicle scrappage program, trade issues, anti-counterfeiting parts actions and legal reforms. It is important to our business, our customers and other stakeholders that we remain a member of the Chamber.
Yet, at the end of the day, Ford will always speak with its own voice. We will do so on climate change (and other issues, for that matter) where it is essential to our business that we articulate our position separately from that of any association of which we are a member.
We also like to think that actions on climate change speak louder than any report or advertisement or even this blog.
Ford spent several years developing CO2 reduction models and studying a range of potential scenarios addressing how light-duty transport might contribute to holding global temperatures below 2 degrees Celsius change via meeting 450 to 550 ppm stabilization pathways. The scenarios looked across a range of conditions and assumptions related to vehicle technologies, baseline fuels, biofuels, electricity usage costs and consumers. And while the models aren't intended to provide "the answer," they do help shape our technology choices for our product strategy.
The result is that we have a product plan - linked to the science of climate change - that will deliver the reductions in vehicle CO2 emissions required to contribute to stabilization. We have publicly committed to a 30 percent reduction in CO2 emissions in our vehicles by 2020. And we are already well into delivering on our plan. Over the next few years, Ford is investing nearly $14 billion in advanced technology vehicles in the U.S. alone.
At the end of the day, we believe our position on climate change is very clear. You know it by our actions. You see it in our commitment to reduce the CO2 emissions from both our products and facilities. Bottom line - we are doing what's right for our customers and the environment.
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Teutonic Temperature Control is a heating and air conditioning company which sells, installs, maintains, and repairs air temperature control and air quality equipment for residential and commercial customers. This company serves the greater Chicagoland area, including Lake Villa, Glen Ellyn, Hinsdale, Bensenville, Bloomingdale, Morton Grove, Northfield, Highland Park, Kildeer, Volo, Vernon Hills, Lake Barrington, Grayslake, Buffalo Grove, Deerfield, Lindenhurst, Channel Lake, Venetian Village, Wadsworth, Russell, Fox Lake, Grandwood, Spring Grove, Johnsburg, Gages Lake, Round Lake Beach, Ingleside, Round Lake, Gurnee, and Ringwood. Services available from this company include air conditioner service and repair, furnace and boiler service and repair, ductwork for new construction and remodeling, venting and flue liners, water heater installation and repair, indoor air quality equipment such as purifiers and humidifiers, in-floor heaters and garage heaters, Space Paks, full-house fans and attic fans, and the Unico System.
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Heating & Air Conditioning Air conditioning & Heating Contractors - Residential Duct & Duct Fittings Heating & Air Conditioning - Filters Heat Exchangers Leak Detecting Instruments Sheet Metal Equipment & Supplies Sheet Metal Work Thermostats Air Conditioning Equipment - Room Units Water Heaters - Dealers Water Heater - Tankless Air Conditioning Repair Air Conditioning Systems - Cleaning Air Duct Systems Heating Equipment & Systems Cleaning & Repair Air Purifying & Cleaning Systems & Equipment Air Conditioning Supplies & Parts Boilers - New & Used Boilers - Supplies & Parts Electric Heating Elements Furnaces - Industrial Humidifying Apparatus Water Heaters - Parts & Supplies Air Conditioning Contractors & Systems Boilers - Repair & Cleaning Heating Contractors Ventilating Contractors Water Heaters - Repairing Plumbing, Heating, and Air-Conditioning Contractors (NAICS: 238220)
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"The urgent consideration of the public safety may undoubtedly authorize the violation of every positive law. How far that or any other consideration may operate to dissolve the natural obligations of humanity and justice, is a doctrine of which I still desire to remain ignorant."
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"Law enforcement officers are never 'off duty.' They are dedicated public servants who are sworn to protect public safety at any time and place that the peace is threatened. They need all the help that they can get."
"This positive endeavor will benefit our children enrolled in the local schools and provide a safety enhancement for our citizens. We are very excited to be a part of this program and believe it will be a great asset to our community."


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Air Marshals Cite Security Concerns
NPR's Scott Simon takes a moment to note the complaints of air marshals who say their security is being compromised by having to stay at only certain hotels where they must identify themselves as marshals.
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This week, Nancy Finken and Bill Stephan preview of a couple of things at the Lied Center for Performing Arts in Lincoln. "Hello, Broadway" is a cabaret on September 11th which will showcase local talent beside a few big Broadway stars. Stan Brown will be sings "Cross That River" from the musical "Cross That River." Also, Susan Werner talks about her concert on Sept. 6th. Werner also sings "Back to the Land." Dulces Voces (Curt Butler, Holly Heffelbower, Jane Mehrens, Jennifer Stevens, and Laura Waldman) talk about their "20 Years of Sweet Voices" concert on Sept. 7th @ Holy Trinity Church in Lincoln. Also, they'll sing a couple of songs, "Ave Maria" and "Tres Morillas." The 5 Browns are at the Midwest Theater in Scottsbluff on Thurs. Sept. 12th. Billy Estes tells us all about these piano playing siblings. Lincoln Community Playhouse has a production of "Spamalot." Morrie Enders talks about this fun musical. A statewide arts calendar. Chadron State College's Una Taylor and Sid Shuler tell us what's happening musically at the college this fall. Also, Layne Pierce, Pat Leach, and Scott Clark talk about the winning book for "One Book, One Lincoln," and it's "The Unlikely Pilgrimmage of Harold Fry" by Rachel Joyce. And, we'll get an Omaha Symphony season preview by KVNO's Ben Rasmussen.
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Synthetic marijuana is sold under a wide range of names and brands around the world. We are attempting to catalogue every brand and street name.
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As basic transportation goes, there's not a lot to complain about with the Toyota Yaris. The five-door hatch (not to mention its JDM cousin, the Vitz) are due for upgrades, though, having toddled along in its current form since the 2011 model year. Now, we have what looks to be leaked images of the new Yaris, straight from a Japanese brochure.
2016 Toyota Yaris
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- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
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- Compare Volvo XC90 and Lincoln MKX


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The average salary of a(n) Accountant in Columbia, Missouri is $57,339.
The average hourly rate of a(n) Accountant in Columbia, Missouri is $27.57.
The average bonus of a(n) Accountant in Columbia, Missouri is $2,007.00.
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New Girl star Zooey Deschanel blasts post-pregnancy bodyshamers
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You won't believe what New Girl's Schmidt looks like now...
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New Girl star Zooey Deschanel 'can't wait to meet our little one' as she confirms she is pregnant with first baby
The actress is delighted by her happy news.
9 celebrities who rock the glasses look
Contact lenses? Pfft
Emmy Awards 2014 fashion: Best and worst dressed, from Sarah Hyland to Lena Dunham
They do know it's OITNB don't they? Awkward.
Mark Wahlberg in Transformers Age of Extinction: 10 actors that should have known better
Most good actors have a few film stinkers on their resumes and it looks like Mark Wahlberg can add Transformers: Age of Extinction to his.
New Girl season three: Why you need to be excited
The time has come at last... New Girl season three has finally started in the UK on E4. It's been a long winter of avoiding what fans in the US have been saying. But here's what you might have forgotten from season two, plus some hints at what we've got to look forward to in the new series.
The Golden Globes 2014: Best and worst dressed, from Cate Blanchett to Zooey Deschanel
Never mind best picture. We look at who were the winners and losers on the Golden Globes 2014 red-carpet.
Prince 'to cameo in New Girl's post-Super Bowl episode' in first-ever TV sitcom appearance
Prince will reportedly play himself in a post-Super Bowl episode of New Girl.
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EXCLUSIVE: Rising British singer Foxes is being hunted down on the streets of America – but mainly by fans of 'lookalike' celebrities.
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The actress and musician Zooey Deschanel was shocked to discover a TV channel had wrongly named her as one of the suspects in the Boston marathon bombings.
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The hit US sitcom New Girl is set to be back on UK screens sooner rather than later, after E4 confirmed the start date for the second series of the show.
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John Anthony will be Appearing at Renzo's every other Thursday in between Ka-Ray-Oke. Start time will be 7PM! So come out and listen to the sounds of John Anthony every other Thursday Night! John will be singing and performing many of the Old Standards and Hits we all know and Love!
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Gary Benjamin '70
President and COO, Champion, Inc.
Iron Mountain, MI
LSSU Business, Economics, and Legal Studies Distinguished Alumni '07
Former LSSU Board Trustee
The Lake Superior State University Investment Club helped with marketing the 45th annual International 500 Snowmobile Race. The club raised more than $2,000 to help finance their annual trip to New York City. For more of the story click here.
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Majoring in Business Admin. - Management
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Harbor Springs, MI
I enjoy Lake State because of the small size; family like atmosphere and; people willing to help.
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We present an original statistical classification method using a deformable template model to separate natural objects from man-made objects in an image provided by a high resolution sonar. A prior knowledge of the manufactured object shadow shape is captured by a prototype template, along with a set of admissible linear transformations, to take into account the shape variability. Then, the classification problem is defined as a two-step process: 1) the detection problem of a region of interest in the input image is stated as the minimization of a cost function; and 2) the value of this function at convergence allows one to determine whether the desired object is present or not in the sonar image. The energy minimization problem is tackled using relaxation techniques. In this context, we compare the results obtained with a deterministic relaxation technique and two stochastic relaxation methods: simulated annealing and a hybrid genetic algorithm. This latter method has been successfully tested on real and synthetic sonar images, yielding very promising results
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The Wildwood Crest Beach Patrol won four of six races and captured its third straight team title at the Tri-Wood Lifeguard Champion-ships on Sunday at the Lincoln Avenue beach in Wildwood.
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Between Whitby and Saltburn, The Old Post Office Bed and Breakfast offers accommodation on England's north-east coast.
"We had a great time at The Old Post Office: we fou…he price reasonable. What a lovely place to stay."
Located in Hinderwell in the region of North Yorkshire, this vacation home and is 8 miles from Whitby. The property is 24 miles from Scarborough and features views of the garden.
22 Long Row is a vacation home is located in Hinderwell in North Yorkshire and and is 8 miles from Whitby. The property features views of the garden and is 24 miles from Scarborough.
Featuring a garden, Crow'S Nest is a vacation home located in Hinderwell in the region of North Yorkshire. The property is 9 miles from Whitby and free private parking is provided.
12 reviews
Located in Hinderwell, 8 miles from Whitby, The Runcible Spoon features free WiFi access and free private parking. Guests can enjoy the on-site restaurant.
"clean recently refurbished room over the restauran…ld recommend a stay here, keep up the great work."
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Water Polo legends
Wednesday, July 27, 2016
Wednesday, June 15, 2016
1982 Guayaquil: The team of Yugoslavia
Labels: 1980-1989, Yugoslavia
1982 Guayaquil: The team of Netherlands
Labels: 1980-1989, Netherlands
1982 Guayaquil: The team of Italy
1982, Guayaquil: The silver team of Hungary
1982 Guayaquil: The bronze team of West Germany
1982, Guayaquil: The golden team of USSR
The team of USSR coached by Boris Popov, winner in Guayaquil 1982 World Championships. The team: Eugeni Shraronov, Vladimir Akimov, Aleksei Vdovin, Nikolai Smirnov, Eugeni Grishin, Alexander Kleimenov, Alexander Kabanov, Erkin Shagaev, Hourlan Mendygaliev, Mikhail Ivanov, Georgy Mshvenieradze, Sergei Kotenko.
Source: Il mondo della Pallanuoto, August 1982 - Sandro Castellano
Tuesday, May 10, 2016
1957: The Champions of Szolnoki Dozsa SC
Thursday, May 5, 2016
1979, Mexico City: The golden Universiade USA team
Another picture of the golden United States Team at the World University Games 1979 in Mexico City.Top Row L-.R: Asst. Coach Rick Rowland, Jack Graham, John Dobrott, Peter Campbell, Jody Campbell, John Gansel, Greg Boyer, Terry Schroeder, Jeff Stites, Head Coach Dante Dettamanti. Bottom Row L-R: Manager Doug Arth, Marty Davis, Doug Burke, Dave Myers
Source: courtesy of Dante Dettamanti
1979, Mexico City: The golden Universiade USA team
The golden United States Team coached by Dante Dettamanti at the World University Games 1979 in Mexico City. Ranking: 1) United States, 2) Russia, 3) Yugoslavia, 4) Romania, 5) Cuba, 6) Hungary, 7) Italy. A very strong competition as many countries had members of their National Team present in preparation for 1980 Olympic Games in the next year. Also present was National Team Head Coaches such as Miro Cirkovic (Yugoslavia) and Boris Popov (USSR) From L-R: Greg Boyer, Jody Campbell, Peter Campbell, Jeff Stites, Jack Graham, Terry Schroeder, Doug Burke, Dave Myers, John Dobrott, Marty Davis, John Gansel.
Source: courtesy of Dante Dettamanti
1971 Barcelona: The golden Junior Hungarians.
The team of Hungary gold winner in Barcelona 1971 European Junior Championships. The team: Huazler, Farago, Magas, Hamory, Horvath, Szello, Ipacs, Balla, Szittya, Debrezeni, Horvath II. Ranking: 1. Hungary, 2. Spain, 3. USSR, 4. Romania, 5. Italy, 6. Netherlands, 7. Germany, 8. Greece
Wednesday, May 4, 2016
1985, Duisburg: The National team of Italy
The National team of Italy that took part in the fourth edition of FINA World Cup held in 1985 in Duisburg, West Germany. Standing L-R: Averaimo, Cadarella, Campagna, Pisano, Postiglione, Missaggi, Trapanese, Denerlein (Head Coach). Squatting L-R: Fiorilo, D'Altrui, Steardo, La Cava, Ferretti, Tempestini. The ranking: 1. West Germany, 2. USA, 3. Spain, 4 Yugoslavia, 5. Italia, Netherlands, Australia, Greece
Source: courtesy Marco D'Altrui
Sunday, May 1, 2016
1924: Match in the pool of Toulouse TOEC
Match of the «Dauphins du TOEC Toulouse» in the pool Ernest Dufer at the Ponts Jumeaux in 1924
Source: http://www.ladepeche.fr/
Saturday, April 30, 2016
1981: The US team, Bucharest Universiade winner
1988, Seoul: action during the final
Labels: 1980-1989, Action, Jugoslavia, USA
1988, Seoul: The silver National team of USA
The US team silver winner in Seoul 1988 Olympic Games: James Bergeson, Greg Boyer, Peter Campbell, Jeffrey Campbell, Jody Campbell, Christopher Duplanty, Michael Evans, Douglas Kimbell, Edward Klass, Alan Mouchawar, Kevin Robertson, Terry Schroeder, and Craig Wilson
Source: Pascal Rondeau, Getty images
Friday, April 29, 2016
1962 The team of Sportiva Nervi
1974, Teheran: Asian Games awarding ceremony
1974, Teheran: The Champions of Iran
The National team of Iran gold winner in Teheran 1974 Asian Games. Standing L-R: Reza Kamerani, Hosein Nasim, Ahmad peydayesh, Majdpour, Angelescu (Head Coach), Bahram Tavakoli, Firooz Mohammadi, Hosein Tavakoli (Captain) Squatting L-R: Ahmad Yaghoti, Heydar Shonjani, Morteza Shariat, Dariosh Movahedi.
Source: courtesy Aram Eidipour
Thursday, April 28, 2016
1905: The team of Schwimmclub SC Austria
1930 The National team of Hungary
Monday, April 25, 2016
1987 The Champions of Sisley Pescara
Sunday, April 24, 2016
1966: Utrecht European Championship awarding
Labels: 1960-1969, Germany, Netherlands, USSR, Yugoslavia
Tuesday, April 19, 2016
1927: Water Polo in Santander, Spain
Thursday, April 14, 2016
1960: Water Polo match in the port of Volos, Greece
1991, Havana: Fidel Castro with the team USA
Monday, April 11, 2016
1929: Final match for the French Championship
Thursday, April 7, 2016
1968: The team of Rari Nantes Salerno
The team of Rari Nantes Salerno coached by Gieppino D Altrui promoted in B Category of the Italian Championship in 1968. Standing L-R: Gianfranco Camisa, Dario Salvati, Roberto Agostino, Mariano Aliberti, mister Geppino D'Altrui, Nicola Borrelli, Paolo Lista, Sergio Mogavero, Antonio Barela, Gino Stefanelli - Squatting L-R: Pasquale Rossi, Antonio D'Anna, Biagio Agostino, Giuseppe Casella
Tuesday, April 5, 2016
1922: The National team of Belgium
The National team of Belgium in 1922. Seating L-R: René Bauwens, Maurice Blitz, Pierre Dewin Standing L-R : Joseph Pletinckx, Wyngaerdt, Hecfinck, Paul Gailly, Van der Eyden
1922: The team of "Libellule de Paris"
The team of "Libellule de Paris" at the indoor pool of Paris, Hebert in 1922
Saturday, April 2, 2016
1923: The National team of France vs Netherlands
The National team of France that played against the team Netherlands in Paris in 1923
1919: Water Polo at Villennes sur Seine, Paris
Water Polo match at Villennes sur Seine, Paris on the occasion of "Touring Club de France" jubilee in 1919.
1911: The National team of France
The National team of France that played against Belgium at Joinville-le-Pont, Paris in 1911. Source: http://gallica.bnf.fr/
1920, Antwerp: The National team of France
Tuesday, March 29, 2016
1980: CSK Moscow European Cup winner
Monday, March 28, 2016
1933: KPK Korčula Vs. HMS Queen Elisabeth team
1969: The team of "Paleo Faliro" Athens, Greece
Sunday, March 27, 2016
1969: The National team of Italy in Trofeo Italia
Saturday, March 19, 2016
1952: The Champions of Balluta WPC, Malta
1952: The winners of Balluta WPC
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Don't-Miss Display Stories
Apple retires its Thunderbolt Display without warning or a successor
Apple is discontinuing its Thunderbolt Display, the high-resolution external display that users of the MacBook and other Macs could use to get a better picture and work with more apps.
Apple pushes into virtual reality by hiring top VR expert
Apple has lured a top virtual reality researcher away from Virginia Tech.
Dell unveils stunning 4K OLED UltraSharp display and declares war on bezels
Dell's 2016 monitor lineup includes a stunning OLED display, InfinityEdge bezels, and wireless phone charging.
A new HDMI certification program will make it easier to avoid crappy cables
Certified cables will have gone through expanded cable speed tests at an HDMI-authorized testing center to certify that they are capable of delivering bandwidth of 18Gbps, and that they radiate very little EMI.
Samsung's new FreeSync monitor will wirelessly charge your phone, too
The SE307 monitor is optimized for gaming and uses the Qi wireless charging standard
Display Videos
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I wonder if it is possible to create a library search page using WordPress?
I am new using WordPress and just have experience creating my own blog. Recently, I am helping a small library to create their library website. And I have some questions. If I have an Excel file which contains all the information, such as names of the books, authors and descriptions, can I create a search page that can let users search for the books in this database and get the result page?


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Posted on 29 March 2012 by KWBG
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Boone Municipal, IA
Last Updated on Jul 30 2016, 8:55 am CDT
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Wind: East at 4mph
Humidity: 94%
Dewpoint: 66.2°F
Your 5-Day Forecast at a Glance
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6 a.m. to 6:30 p.m. PT
7 days a week
Plenty of edge-of-your seat thrills and chills, especially when you're trying to decide if it's a '3' or an '8' that goes in that bottom-left square.
Telegames has created the largest and most comprehensive compilation of sudoku puzzle games ever released for a portable gaming system.


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11 reviews | 4.5 out of 5
I like this product for a quick testing of the water conditions. It only takes 30 secs and very easy to use. I like that you can see the nitrates and nitrites on the same strip since that is so important and what I am most concerned with.
Gives a rough estimate of your water's condition. It is easy and quick to do. Complaint: reading the colors isn't that easy and after about 1min the colors start to fade due to the air, so you have to be quick. Not as accurate as a standard liquid test but it's cheaper and you can test many conditions at once. Wish it had ammonia too.
Only good for a quick test to see your water parameter. Walmart.com sell a master kit on here cheap which I got and use a few time. Doing weekly water change ..and you won't even need this at all.
These test strips are quick and easy, but are accurate as well. They can be used for both freshwater and saltwater aquariums. When I first purchased this brand, I tested my aquariums with both the test strips and the chemical kit. I found the strips to be amazingly accurate, and far easier to use than chemical tests. With 4 aquariums, I use a lot of test strips, especially since I must adjust the Ph with every water change. These are economical as well, and therefore my preferred brand. I highly recommend these for anyone with an aquarium.
Work great.
These test strips are a great value and do the job well.
I'm nursick a sick Berta with badly torn fins back to health. These strips seem to be pretty accurate. I am using them weekly along with water changes in his tank and am seeing fin regrowth and an active fish who is eating well and making bubble nests.
I've been using this product for years but seems to be unavailable now in local Wal-Mart stores
I don't have much need for the tests other than hardness, but that function alone is worth the price. They're easy to use and are accurate enough for my purposes. I use them to monitor a low-usage very old water softener.


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Purple Pixie® loropetalum is great in mass plantings, on slopes, or cascading over retaining walls.
'Orange Rocket' Berberis
Bring out the striped cushions and colorful umbrellas, and get transported to a dream vacation spot right in your backyard.
'Black Adder' phormium
This deck more than doubles the home's living space with ample sunbathing, conversation, and entertaining areas.
Concrete firepit
Bring the beach to your own backyard for a quick "getaway."
Add stature with stacked slabs of argillite.
Breezy, loose-knit rope hammock
Get organized: Maximize walls
Cover the understory of a bare back fence with potted succulents.
A single plant with a bold, sculptural shape is easier on the eye than a mixed planting.
We're all about the fuzzy grass.
Agave, grasses, and yarrow
Small space outdoor patio and low-water plants
Aeonium arboreum
Easy-care deck with kangaroo paws


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Proenza Schouler's Fall 2010 Show Includes J-Brand Jeans And Prep School Cyber Punks
If the Proenza Schouler girl from last spring was your party girl that stayed out beyond her bedtime (what, with her colored hair streaks and micro minis), the girl of fall '10 has grown up, wised up, and gussied up in proper prep-school-meets-cyber-punk form. The saddle shoes, smart jackets, and sleeveless blouses are all Ivy League standards, but the graffiti-print dresses, jeans from their J-Brand collaboration, and leather and feather accents are sure to get you sent to detention. Lazaro and Jack finished it all off with a DIY bob, unbearably sexy thigh-high socks, and chic little bags that you can actually buy right now. How's that for smart fashion?
Images via Style.com.
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Proof Denim Will Always Matter
When we think about buying denim, we often think about fit and wash. But nowadays, jeans, jackets, and other clothing items made from denim can cost more than a month's rent, so it's the price tag, too, that requires extra consideration before committing. To understand why prices have gotten so high, it's important to know ...
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Dec 14, 2015


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|Viewing Single Post From: Spoilers for the week of October 21st
|Oct 9 2013, 05:42 PM
I wonder if the ultimatum is Theresa-related--and if it will actually drive JJ right into Theresa's arms...or bed. Whether it is or not, Jen-Jen continues to be made of fail as a mom. You'd think she'd have figured out by now that her ultimatums have a tendency to blow up in her face.
|Spoilers for the week of October 21st · DAYS: News, Spoilers & Discussion


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Christopher Johnson
Revolving Door
Who's coming and who's going. Tell us about your job move! Receive the Revolving Door Newsletter with expert analysis by email twice a week.
March 5, 2012: Christopher Johnson has been named vice president, product management, at Volly. He had been senior vice president, programming and product strategy at UGO Entertainment.
December 4, 2006: Christopher Johnson has been named content director at Hearst Magazines Integrated Media. He had led the portal partnerships division at IAC Search & Media. (release)


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Skydiving.com has been hooking up men and women who are seeking to skydive with the leading sky diving service providers throughout the United States for several years! We are delighted to cater to Orrtanna, along with the whole state of Pennsylvania. If you are trying to skydive in the near future, contact us right away at 1-800-617-7948 so one of our staff members can easily secure your dive for you. Hoping to skydive outside of Adams County? No problem! As we stated, we have network affiliated sites all throughout the whole entire state of Pennsylvania, in addition to the whole nation. Simply pick up the phone and contact us!
Every single year, hundreds of people from Pennsylvania call Skydiving.com in order to carry out their initial sky diving trip around Orrtanna. We try to service everyone wanting to skydive within the entire United States. With tons of venues throughout the country, there is no doubt that Skydiving.com features the leading amount of skydiving network affiliates! The primary step to experiencing the spectacular realm of skydiving is to give our team a phone call at 1-800-617-7948 and help one of our courteous team representatives get you on your way! It is definitely a special experience which you would never forget for the rest of your life, so precisely what are you waiting for?


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We recommend using the latest version of Internet Explorer, Safari, Firefox or Chrome.
You can also call us Toll Free at 1-877-877-5655 to talk to a friendly member of our sales team.
Looking for a steak knife that not only looks good, but is practical, too? Check out the Walco 5" Forged Steak Knives - BOSTON CHOP Series (670527). The curved design of the handle increases grip, so the diner can easily cut their steak. Perfect for steakhouse use, but also great for any restaurant that serves meat dishes.
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Mechanic Westgate, Wof & Car Servicing - Pit Stop
Welcome to Pit Stop Westgate where you've come to the right place!
Pit Stop Westgate offers high quality and highly competitive car servicing and car repairs and we are very proud to be servicing customers across West Auckland.
In addition to our full range of car servicing and car repair services, we offer Warrant of Fitness (WOF) checks and specialize in brake, exhaust and suspension repairs and services. Call the phone number or drop into Pit Stop Westgate today to see how our team can help you or organize a Free safety check for your vehicle.
CONTACT INFO:Westgate Car Servicing
Pit Stop Westgate
Cnr Fernhill Dr & Cellar Court
Westgate Owner: Mike Bone
OPENING HOURS:Monday - Friday: 00:00 - 00:00
Saturday: 00:00 - 00:00
Sunday: 00:00 - 00:00
Fax : 09 832 3884


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the feelgood Life
"Live one day at a time, in purpose to achieve moments of peace of mind."
– Rose A. Weinberg
Over the past 16-years Rose has created attainable wellness by fusing; breathing, core movement, energy, homeopathy, meditation, nutrition, Reiki, to create the feelgood life you choose. It's simple, it's attainable and it's sustainable!
"Thank you for your referrals; creating the feelgood life for your circle of peeps, means your circle is all around feelgood!"
with gratitude and thanks, Rose


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He pulled his dick out during the Bourne Ultimatum, ruined it for me.
You must be Logged in to post a comment
Bourne Ultimatum is ALWAYS ruining a good blowjob. Stick with porn.
Seriously, turn the TV off during sex!
What did he ruin for you? His dick? The movie? Both?
The movie ruined his dick?
Stuck up bitch!
Matt Damon ruined it long before he did.
You mean it made the movie worth watching?
During the whole movie?
Maybe he pulled his dick out of his pants and wanted sex, so she didn't get to watch the movie.
I think from the context she means it ruined the movie as in when she no longer had the dick inside her, her enjoyment ended.
"I've got an ultimatum for you; suck it or go home."


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'Best Olive Oils Marketplace' Offers World's Top-Rated Extra Virgin Olive Oils
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Planting of Over 300,000 Olive Trees Underway in Pothohar, Pakistan
Under a five-year plan initiated in 2015, the agriculture department of Pakistan's Punjab province is providing two million olive saplings free of charge to farmers in the Pothohar region.
Class Certification Awarded in False Advertising Case Against Filippo Berio
A U.S. District Judge granted class certification to those who bought any brand Filippo Berio olive oil with the exception of their organic olive oil, between May 2010 and June 2015.
New Blight Alarms California Olive Growers
The pathogen Neofabraea has been observed on both Arbosana and Arbequina trees in the Sacramento Valley, Glenn County and San Joaquin.
Olive Oil Sommelier Certification Course at New York's International Culinary Center
The renowned International Culinary Center (ICC) in New York and the Olive Oil Times Education Lab will present the first Olive Oil Sommelier Certification Level 1 Course October 8-10 at the ICC's SoHo campus.
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Master Milling Course Returns to Davis
The program will once again be led by Leandro Ravetti, one of the world's leading experts in the growing, processing and standards of olive oil.
IOC Approves New Limits for Fatty Acids, Restoring 'Extra Virgin' Status to Southern Italian Varieties
The International Olive Oil Council approved new limits for fatty acids, allowing some varietals with unique chemical makeups to meet the parameters for the extra virgin grade.
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Fire Devastates Ybarra's Seville Facility
Almost half of the Seville based Ybarra factory was destroyed in a blaze that broke out Saturday afternoon. The company vowed to rebuild as soon as possible.
Research Shows Leccino Less Susceptible to Xf
According to a new study, the Leccino olive variety appears to be 'tolerant' to the attack of the Xylella fastidiosa bacterium that has wiped out large swaths of Italian olive-growing regions.
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Blog Posts in Category: 2013
October 2, 2013
With September coming to an end that means the countdown to all sorts of exciting events can begin. One of my personal favorites is homecoming! There is nothing better than soaking up some Wildcat pride on a beautiful fall weekend in New Hampshire. There are all sorts of events happening the weekend of homecoming but one event is not only fun but also good for your health. Fun AND healthy? Yes, it is possible! The homecoming 5k race is a great way to get a little exercise while enjoying the... Read More
Recent Posts
Eating Locally Can Be Healthy and Delicious Looking to eat fresh foods that are organic and full of... Read more
How Biofeedback Can Help You Destress The year is flying by, but stress always seems to be present... Read more
How Harvard Pilgrim Wellness Connection Can Save You Money Some days the motivation to go to the... Read more