text:
Most Popular "Moving" Titles
- Movies or TV
- Genres
- Keywords
- IMDb Rating
- Instant Watch Options
- In Theaters
- On TV
- Release Year
1. Inside Out (I) (2015)
PG | 95 min | Animation, Adventure, Comedy
After young Riley is uprooted from her Midwest life and moved to San Francisco, her emotions - Joy, Fear, Anger, Disgust and Sadness - conflict on how best to navigate a new city, house, and school.
Writers: Pete Docter, Ronnie Del Carmen, Meg LeFauve, Josh Cooley, Michael Arndt, Bill Hader, Amy Poehler, Simon Rich | Directors: Pete Docter, Ronnie Del Carmen | Stars: Amy Poehler, Bill Hader, Lewis Black, Mindy Kaling
Votes: 338,981 | Gross: $356.45M
2. American Beauty (1999)
R | 122 min | Drama
A sexually frustrated suburban father has a mid-life crisis after becoming infatuated with his daughter's best friend.
Writer: Alan Ball | Director: Sam Mendes | Stars: Kevin Spacey, Annette Bening, Thora Birch, Wes Bentley
Votes: 818,709 | Gross: $130.06M
3. Good Will Hunting (1997)
R | 126 min | Drama
Will Hunting, a janitor at M.I.T., has a gift for mathematics, but needs help from a psychologist to find direction in his life.
Writers: Matt Damon, Ben Affleck | Director: Gus Van Sant | Stars: Robin Williams, Matt Damon, Ben Affleck, Stellan Skarsgård
Votes: 601,336 | Gross: $138.34M
4. The Lost Boys (1987)
R | 97 min | Comedy, Fantasy, Horror
After moving to a new town, two brothers discover that the area is a haven for vampires.
Writers: Jan Fischer, James Jeremias, Jeffrey Boam | Director: Joel Schumacher | Stars: Jason Patric, Corey Haim, Dianne Wiest, Barnard Hughes
Votes: 92,501 | Gross: $32.22M
5. Alpha Dog (2006)
R | 122 min | Biography, Crime, Drama
A drama based on the life of Jesse James Hollywood, a drug dealer who became one of the youngest men ever to be on the FBI's most wanted list.
Writer: Nick Cassavetes | Director: Nick Cassavetes | Stars: Emile Hirsch, Justin Timberlake, Anton Yelchin, Bruce Willis
Votes: 87,750 | Gross: $15.23M
6. Insidious (I) (2010)
PG-13 | 103 min | Fantasy, Horror, Mystery
A family looks to prevent evil spirits from trapping their comatose child in a realm called The Further.
Writer: Leigh Whannell | Director: James Wan | Stars: Patrick Wilson, Rose Byrne, Ty Simpkins, Lin Shaye
Votes: 201,489 | Gross: $53.99M
7. The Right Stuff (1983)
PG | 193 min | Adventure, Drama, History
The story of the original Mercury 7 astronauts and their macho, seat-of-the-pants approach to the space program.
Writers: Tom Wolfe, Philip Kaufman | Director: Philip Kaufman | Stars: Sam Shepard, Scott Glenn, Ed Harris, Dennis Quaid
Votes: 45,117 | Gross: $21.50M
8. Annabelle (I) (2014)
R | 99 min | Horror, Mystery
A couple begins to experience terrifying supernatural occurrences involving a vintage doll shortly after their home is invaded by satanic cultists.
Writer: Gary Dauberman | Director: John R. Leonetti | Stars: Ward Horton, Annabelle Wallis, Alfre Woodard, Tony Amendola
Votes: 80,826 | Gross: $84.26M
9. Toy Story (1995)
G | 81 min | Animation, Adventure, Comedy
A cowboy doll is profoundly threatened and jealous when a new spaceman figure supplants him as top toy in a boy's room.
Writers: John Lasseter, Pete Docter, Andrew Stanton, Joe Ranft, Joss Whedon, Joel Cohen, Alec Sokolow | Director: John Lasseter | Stars: Tom Hanks, Tim Allen, Don Rickles, Jim Varney
Votes: 619,963 | Gross: $191.80M
10. The Machinist (2004)
R | 101 min | Drama, Thriller
An industrial worker who hasn't slept in a year begins to doubt his own sanity.
Writer: Scott Kosar | Director: Brad Anderson | Stars: Christian Bale, Jennifer Jason Leigh, Aitana Sánchez-Gijón, John Sharian
Votes: 280,538 | Gross: $1.08M
11. Coraline (2009)
PG | 100 min | Animation, Family, Fantasy
An adventurous girl finds another world that is a strangely idealized version of her frustrating home, but it has sinister secrets.
Writers: Henry Selick, Neil Gaiman | Director: Henry Selick | Stars: Dakota Fanning, Teri Hatcher, John Hodgman, Jennifer Saunders
Votes: 142,341 | Gross: $75.28M
12. The Karate Kid (1984)
PG | 126 min | Action, Drama, Family
A handyman/martial arts master agrees to teach a bullied boy karate and shows him that there is more to the martial art than fighting.
Writer: Robert Mark Kamen | Director: John G. Avildsen | Stars: Ralph Macchio, Pat Morita, Elisabeth Shue, Martin Kove
Votes: 126,124 | Gross: $90.80M
13. Poltergeist (1982)
PG | 114 min | Fantasy, Horror
A family's home is haunted by a host of ghosts.
Writers: Steven Spielberg, Michael Grais, Mark Victor | Director: Tobe Hooper | Stars: JoBeth Williams, Heather O'Rourke, Craig T. Nelson, Beatrice Straight
Votes: 104,845 | Gross: $76.60M
14. The Butterfly Effect (2004)
R | 113 min | Sci-Fi, Thriller
Evan Treborn suffers blackouts during significant events of his life. As he grows up, he finds a way to remember these lost memories and a supernatural way to alter his life by reading his journal.
Writers: J. Mackye Gruber, Eric Bress | Directors: Eric Bress, J. Mackye Gruber | Stars: Ashton Kutcher, Amy Smart, Melora Walters, Elden Henson
Votes: 356,096 | Gross: $0.02M
15. Poltergeist (2015)
PG-13 | 93 min | Horror, Thriller
A family whose suburban home is haunted by evil forces must come together to rescue their youngest daughter after the apparitions take her captive.
Writers: David Lindsay-Abaire, Steven Spielberg, Michael Grais, Mark Victor | Director: Gil Kenan | Stars: Sam Rockwell, Rosemarie DeWitt, Kennedi Clements, Saxon Sharbino
Votes: 41,410 | Gross: $47.42M
16. The Tree of Life (2011)
PG-13 | 139 min | Drama, Fantasy
The story of a family in Waco, Texas in 1956. The eldest son witnesses the loss of innocence and struggles with his parents' conflicting teachings.
Writer: Terrence Malick | Director: Terrence Malick | Stars: Brad Pitt, Sean Penn, Jessica Chastain, Hunter McCracken
Votes: 135,899 | Gross: $13.30M
17. The Man from Earth (2007)
Not Rated | 87 min | Drama, Sci-Fi
An impromptu goodbye party for Professor John Oldman becomes a mysterious interrogation after the retiring scholar reveals to his colleagues he has a longer and stranger past than they can imagine.
Writer: Jerome Bixby | Director: Richard Schenkman | Stars: David Lee Smith, Tony Todd, John Billingsley, Ellen Crawford
Votes: 128,963
18. The Piano (1993)
R | 121 min | Drama, Music, Romance
A mute woman along with her young daughter, and her prized piano, are sent to 1850s New Zealand for an arranged marriage to a wealthy landowner, and she's soon lusted after by a local worker on the plantation.
Writer: Jane Campion | Director: Jane Campion | Stars: Holly Hunter, Harvey Keitel, Sam Neill, Anna Paquin
Votes: 63,692 | Gross: $40.16M
19. Terms of Endearment (1983)
PG | 132 min | Comedy, Drama
Follows hard-to-please Aurora looking for love and her daughter's family problems.
Writers: Larry McMurtry, James L. Brooks | Director: James L. Brooks | Stars: Shirley MacLaine, Debra Winger, Jack Nicholson, Danny DeVito
Votes: 40,134 | Gross: $108.42M
20. Failure to Launch (2006)
PG-13 | 97 min | Comedy, Romance
A thirtysomething slacker suspects his parents of setting him up with his dream girl so he'll finally vacate their home.
Writers: Tom J. Astle, Matt Ember | Director: Tom Dey | Stars: Matthew McConaughey, Sarah Jessica Parker, Kathy Bates, Terry Bradshaw
Votes: 58,217 | Gross: $88.66M
21. Aquamarine (2006)
PG | 104 min | Comedy, Family, Fantasy
Two teenage girls discover a mermaid in their beach club's swimming pool.
Writers: John Quaintance, Jessica Bendinger, Alice Hoffman | Director: Elizabeth Allen Rosenbaum | Stars: Emma Roberts, Joanna 'JoJo' Levesque, Sara Paxton, Jake McDorman
Votes: 30,301 | Gross: $18.60M
22. Marty (1955)
Approved | 90 min | Drama, Romance
A middle-aged butcher and a school teacher who have given up on the idea of love meet at a dance and fall for each other.
Writer: Paddy Chayefsky | Director: Delbert Mann | Stars: Ernest Borgnine, Betsy Blair, Esther Minciotti, Augusta Ciolli
Votes: 15,552
23. Hearts in Atlantis (2001)
PG-13 | 101 min | Drama, Mystery
A widowed mother and her son change when a mysterious stranger enters their lives.
Writers: Stephen King, William Goldman | Director: Scott Hicks | Stars: Anthony Hopkins, Anton Yelchin, Hope Davis, Mika Boorem
Votes: 30,255 | Gross: $24.19M
24. Cheaper by the Dozen (2003)
PG | 98 min | Comedy, Family
With his wife doing a book tour, a father of twelve must handle a new job and his unstable brood.
Writers: Frank B. Gilbreth Jr., Ernestine Gilbreth Carey, Craig Titley, Sam Harper, Joel Cohen, Alec Sokolow | Director: Shawn Levy | Stars: Steve Martin, Bonnie Hunt, Hilary Duff, Piper Perabo
Votes: 74,818 | Gross: $138.61M
25. Klute (1971)
R | 114 min | Crime, Mystery, Thriller
A small-town detective searching for a missing man has only one lead: a connection with a New York prostitute.
Writers: Andy Lewis, David E. Lewis | Director: Alan J. Pakula | Stars: Jane Fonda, Donald Sutherland, Charles Cioffi, Roy Scheider
Votes: 15,665
26. Saturday Night Fever (1977)
R | 118 min | Drama, Music
A Brooklyn teenager feels his only chance to succeed is as the king of the disco floor. His carefree youth and weekend dancing help him to forget the reality of his bleak life.
Writers: Nik Cohn, Norman Wexler | Director: John Badham | Stars: John Travolta, Karen Lynn Gorney, Barry Miller, Joseph Cali
Votes: 53,291 | Gross: $94.21M
27. A Room with a View (1985)
Unrated | 117 min | Drama, Romance
When Lucy Honeychurch and chaperone Charlotte Bartlett find themselves in Florence with rooms without views, fellow guests Mr Emerson and son George step in to remedy the situation. Meeting... See full summary »
Writers: E.M. Forster, Ruth Prawer Jhabvala | Director: James Ivory | Stars: Maggie Smith, Helena Bonham Carter, Denholm Elliott, Julian Sands
Votes: 29,483 | Gross: $20.97M
28. Catch and Release (II) (2006)
PG-13 | 124 min | Comedy, Drama, Romance
A woman struggles to accept the death of her fiancé and the secrets he kept from her as she rebuilds her life.
Writer: Susannah Grant | Director: Susannah Grant | Stars: Jennifer Garner, Timothy Olyphant, Kevin Smith, Sam Jaeger
Votes: 18,605 | Gross: $15.27M
29. Infinitely Polar Bear (2014)
R | 90 min | Comedy, Drama, Romance
A manic-depressive mess of a father tries to win back his wife by attempting to take full responsibility of their two young, spirited daughters, who don't make the overwhelming task any easier.
Writer: Maya Forbes | Director: Maya Forbes | Stars: Mark Ruffalo, Zoe Saldana, Imogene Wolodarsky, Ashley Aufderheide
Votes: 8,953 | Gross: $1.43M
30. Under the Tuscan Sun (2003)
PG-13 | 113 min | Comedy, Drama, Romance
A writer impulsively buys a villa in Tuscany in order to change her life.
Writers: Frances Mayes, Audrey Wells | Director: Audrey Wells | Stars: Diane Lane, Raoul Bova, Sandra Oh, Lindsay Duncan
Votes: 35,600 | Gross: $43.60M
31. Doctor Zhivago (1965)
PG-13 | 197 min | Drama, Romance, War
The life of a Russian physician and poet who, although married to another, falls in love with a political activist's wife and experiences hardship during the First World War and then the October Revolution.
Writers: Boris Pasternak, Robert Bolt | Director: David Lean | Stars: Omar Sharif, Julie Christie, Geraldine Chaplin, Rod Steiger
Votes: 55,671 | Gross: $111.72M
32. Out of Africa (1985)
PG | 161 min | Biography, Drama, Romance
In 20th-century colonial Kenya, a Danish baroness/plantation owner has a passionate love affair with a free-spirited big-game hunter.
Writers: Karen Blixen, Judith Thurman, Errol Trzebinski, Kurt Luedtke | Director: Sydney Pollack | Stars: Meryl Streep, Robert Redford, Klaus Maria Brandauer, Michael Kitchen
Votes: 52,123 | Gross: $87.10M
33. The Apartment (1960)
Approved | 125 min | Comedy, Drama, Romance
A man tries to rise in his company by letting its executives use his apartment for trysts, but complications and a romance of his own ensue.
Writers: Billy Wilder, I.A.L. Diamond | Director: Billy Wilder | Stars: Jack Lemmon, Shirley MacLaine, Fred MacMurray, Ray Walston
Votes: 108,772
34. Flowers in the Attic (2014 TV Movie)
TV-14 | 86 min | Thriller
After the sudden death of their father, four children face cruel treatment from their ruthless grandmother.
Writers: Kayla Alpert, Virginia C. Andrews | Director: Deborah Chow | Stars: Heather Graham, Ellen Burstyn, Kiernan Shipka, Mason Dye
Votes: 6,286
35. Nancy Drew (2007)
PG | 99 min | Comedy, Crime, Family
Teen detective Nancy Drew accompanies her father on a business trip to Los Angeles, where she happens upon clues to a murder mystery involving a movie star.
Writers: Andrew Fleming, Tiffany Paulsen, Mildred Wirt Benson | Director: Andrew Fleming | Stars: Emma Roberts, Tate Donovan, Max Thieriot, Craig Gellis
Votes: 15,825 | Gross: $25.58M
36. Troll (1986)
PG-13 | 82 min | Comedy, Fantasy, Horror
A wicked troll king in search of a mystical ring that will return him to his human form invades a San Francisco apartment complex where a powerful witch lives.
Writer: Ed Naha | Director: John Carl Buechler | Stars: Michael Moriarty, Shelley Hack, Noah Hathaway, Jenny Beck
Votes: 6,972 | Gross: $5.45M
37. Charlie's Angels: Full Throttle (2003)
PG-13 | 106 min | Action, Adventure, Comedy
The Angels investigate a series of murders which occur after the theft of a witness protection profile database.
Writers: Ivan Goff, Ben Roberts, John August, Cormac Wibberley, Marianne Wibberley | Director: McG | Stars: Drew Barrymore, Lucy Liu, Cameron Diaz, Bernie Mac
Votes: 100,584 | Gross: $100.69M
38. The Outlaw Josey Wales (1976)
PG | 135 min | Western
A Missouri farmer joins a Confederate guerrilla unit and winds up on the run from the Union soldiers who murdered his family.
Writers: Forrest Carter, Philip Kaufman, Sonia Chernus | Director: Clint Eastwood | Stars: Clint Eastwood, Sondra Locke, Chief Dan George, Bill McKinney
Votes: 49,870
39. Bring It On: All or Nothing (2006 Video)
PG-13 | 99 min | Comedy, Sport
A transfer student to a rough high school tries joining the cheer-leading squad and she not only faces off against the head cheerleader, but against her former school in preparation for a cheer-off competition.
Writer: Alyson Fouse | Director: Steve Rash | Stars: Hayden Panettiere, Jake McDorman, JoJo Wright, Emme Rylan
Votes: 14,157
40. The Station Agent (2003)
R | 89 min | Comedy, Drama
When his only friend dies, a man born with dwarfism moves to rural New Jersey to live a life of solitude, only to meet a chatty hot dog vendor and a woman dealing with her own personal loss.
Writer: Tom McCarthy | Director: Tom McCarthy | Stars: Peter Dinklage, Patricia Clarkson, Bobby Cannavale, Paul Benjamin
Votes: 58,094 | Gross: $5.74M
41. Heavenly Creatures (1994)
R | 99 min | Biography, Crime, Drama
Two girls have an intense fantasy life; their parents, concerned the fantasy is too intense, separate them, and the girls take revenge.
Writers: Fran Walsh, Peter Jackson | Director: Peter Jackson | Stars: Melanie Lynskey, Kate Winslet, Sarah Peirse, Diana Kent
Votes: 50,044 | Gross: $3.05M
42. Earth to Echo (2014)
PG | 91 min | Adventure, Family, Sci-Fi
After receiving a bizarre series of encrypted messages, a group of kids embark on an adventure with an alien who needs their help.
Writers: Henry Gayden, Andrew Panay | Director: Dave Green | Stars: Teo Halm, Astro, Reese Hartwig, Ella Wahlestedt
Votes: 15,581 | Gross: $38.92M
43. Reign Over Me (2007)
R | 124 min | Drama
A man who lost his family in the September 11 attack on New York City runs into his old college roommate. Rekindling the friendship is the one thing that appears able to help the man recover from his grief.
Writer: Mike Binder | Director: Mike Binder | Stars: Adam Sandler, Don Cheadle, Jada Pinkett Smith, Liv Tyler
Votes: 83,644 | Gross: $19.66M
44. Weekend (II) (2011)
Not Rated | 97 min | Drama, Romance
After a drunken house party with his straight mates, Russell heads out to a gay club. Just before closing time he picks up Glen but what's expected to be just a one-night stand becomes something else, something special.
Writer: Andrew Haigh | Director: Andrew Haigh | Stars: Tom Cullen, Chris New, Jonathan Race, Laura Freeman
Votes: 19,701 | Gross: $0.47M
45. The Perfect Man (2005)
PG | 100 min | Comedy, Family, Romance
Teenager Holly Hamilton is tired of moving every time her single mom Jean has another personal meltdown involving yet another second-rate guy. To distract her mother from her latest bad ... See full summary »
Writers: Michael McQuown, Heather Robinson, Katherine Torpey, Gina Wendkos | Director: Mark Rosman | Stars: Hilary Duff, Heather Locklear, Aria Wallace, Chris Noth
Votes: 23,442 | Gross: $16.25M
46. Dark Water (2005)
PG-13 | 105 min | Drama, Horror, Thriller
A mother and daughter, still wounded from a bitter custody dispute, hole up in a run-down apartment building. Adding further drama to their plight, they are targeted by the ghost of former resident.
Writers: Kôji Suzuki, Hideo Nakata, Takashige Ichise, Rafael Yglesias | Director: Walter Salles | Stars: Jennifer Connelly, Ariel Gade, John C. Reilly, Tim Roth
Votes: 44,816 | Gross: $25.47M
47. Singles (1992)
PG-13 | 99 min | Comedy, Drama, Romance
A group of twenty-something friends, most of whom live in the same apartment complex, search for love and success in grunge-era Seattle.
Writer: Cameron Crowe | Director: Cameron Crowe | Stars: Bridget Fonda, Campbell Scott, Kyra Sedgwick, Sheila Kelley
Votes: 22,479 | Gross: $18.47M
48. Reds (1981)
PG | 195 min | Biography, Drama, History
A radical American journalist becomes involved with the Communist revolution in Russia and hopes to bring its spirit and idealism to the United States.
Writers: Warren Beatty, Trevor Griffiths | Director: Warren Beatty | Stars: Warren Beatty, Diane Keaton, Edward Herrmann, Jerzy Kosinski
Votes: 16,195
49. Are We Done Yet? (2007)
PG | 92 min | Comedy, Drama, Family
Newlyweds Nick and Suzanne decide to move to the suburbs to provide a better life for their two kids. But their idea of a dream home is disturbed by a contractor with a bizarre approach to business.
Writers: Hank Nelken, Steven Gary Banks, Claudia Grazioso, Norman Panama, Melvin Frank | Director: Steve Carr | Stars: Ice Cube, Nia Long, John C. McGinley, Aleisha Allen
Votes: 15,563 | Gross: $49.63M
50. The Science of Sleep (2006)
R | 105 min | Comedy, Drama, Fantasy
A man entranced by his dreams and imagination is love-struck with a French woman and feels he can show her his world.
Writer: Michel Gondry | Director: Michel Gondry | Stars: Gael García Bernal, Charlotte Gainsbourg, Miou-Miou, Alain Chabat
Votes: 61,406 | Gross: $4.66M


text:
When you keep eating food in a loop-like continuous way.
I was flooping last weekend, happens often when I get stressed.
بواسطة CrystalMCG مايو/أيار 11, 2011
Trending Now
Top Definition
The act of going crazy and attacking something.
" Lauren, stop flooping the bees! "
بواسطة Flooper مايو/أيار 1, 2010

subset: commoncrawl


text:
2016 MCB Convocation Address by Dr. Deborah A. Paul
Thank you Dr. Sligar for the invitation to speak at the convocation, and thank you graduates for graduating so that I could have the opportunity to come back to one of my favorite places. I'm sure that most of you are here today with friends & family that have supported you in reaching this achievement. I want to talk to you today about someone who supported me, my brother Tim.
I was the shy, introverted scientist; Tim was the extroverted, artistic type. He wrote stories and poetry, and was quite a musician – playing many different instruments, though excelling at piano. He could walk into a room full of strangers and make everyone his friend. He was younger than me, but he supported me in so many ways, for example:
1. He was my date for 10 year high school class reunion – since he knew all my friends anyway;
2. He went with me when, in my mid-twenties, I was able to buy my 1st pair of toe shoes – having taken up ballet, which I always loved, a bit late in life. He knew how much it meant to me to have achieved this, and he wanted to be there.
3. He was also one of my biggest boosters for going back to get my PhD. After I had received my Masters in Biology here at Illinois, I wanted to go on for a PhD but I didn't know what area of science I wanted to focus on. So I took a job at Abbott working on the Development side of R & D in Diagnostics, working on tests to detect Hepatitis B infection. After working a few years, I decided what I wanted to do for a PhD and took a leave of absence from Abbott to go back to grad school – combining biochemistry, virology and immunology to study Hepatitis B. Tim was so proud, and would introduce me as "my sister who's working on her PhD."
A few weeks before I left for grad school, Tim ended up in the hospital. He hadn't been feeling well, and all of the lymph nodes all over his body had become enlarged. They ran all sorts of tests, but never figured out the problem. He started feeling better and was released.
A few years passed, and I was working on finishing up my PhD when I got the call that Tim had developed Pneumocystis carinii pneumonia – a type of pneumonia typically only found in immunosuppressed people. The doctors said this was consistent with a new disease that was popping up around the country – AIDS. Two weeks in ICU and a month in the hospital later, Tim survived the pneumonia that killed the majority of AIDs patients, but a few months later he developed cancer and started chemotherapy.
As I was finishing my PhD at this time, I had to decide what I wanted to do next. They had recently discovered the virus that causes AIDS – HIV, and Abbott was one of 5 companies that was to receive viral cultures from NIH to work on tests to protect the blood supply. All my work on Hepatitis B was the perfect set up to work on HIV – and I obviously had a lot of personal reasons to want to work on this virus. So I returned to Abbott, now in the research department, to do research for diagnostics tests for HIV. Unfortunately, Tim died 1 month later; he was 28 years old.
The other people in the department had already started work on an HIV Ab test that would be used to protect blood supply. I wanted to develop a test for the virus itself, and see if it was circulating in the bloodstream – even though the prevailing school of thought was that this would not be the case. I developed an ultrasensitive immunoassay and was able to demonstrate that HIV was indeed present in the bloodstream at various times throughout the disease, and this was significant because you could then:
1. Detect initial infection, which would have been useful for Tim's 1st hospitalization when they could not determine what was wrong with him.
2. Detect viral re-emergence - since most patients, after becoming infected, entered an asymptomatic phase; but later something would trigger the virus to begin reproducing, which was a poor prognostic indicator, usually signaling the start of AIDS related diseases.
3. Monitor therapy – initial therapies were nucleoside analogues, and you could determine if the therapy was working by watching whether the level of circulating virus declined. However, most people also eventually developed drug resistance, so through monitoring for rising viral levels, you would then know to switch to a different therapy.
Abbott also had a Pharmaceutical division, and they were using computer-assisted drug design to develop small molecules that would inhibit the active site of the viral protease. However they needed a way to know which compounds were working. So we collaborated with them – since we were growing virus in culture and monitoring our cultures with the test I developed. We looked for compounds that would kill the virus in culture but leave the human cells healthy. This led to the initial protease inhibitors that were FDA approved and marketed. Though they were not in time for Tim, they changed the tide in the war against HIV infection so that AIDS was not a death sentence but a disease you could live with.
I spent 15 more years in the lab working on HIV and Hepatitis, then moved to business-side of things – though still supporting the work on HIV and Hepatitis. Later this also included work on the next generation nucleic acid tests using PCR to detect HIV, Hepatitis and other infectious diseases.
My career success then enabled me to honor Tim's memory and his support of me by providing support to others through endowing a chair that will reside in the School of Molecular and Cellular Biology, with a joint appointment in the new College of Medicine, in the field of Infectious Disease and Immunology, in Tim's name. I cannot tell you how happy it makes me to be able to do this.
In closing I would like to leave you with these thoughts: Do something that means something to you; that you are passionate about. If you do that, it will, by definition, make you personally successful. When you are able to, honor the support that you have received to achieve that success by giving back – and continue the circle of support.
Now – Go do great things ! Thank you.
~~ Deborah A. Paul, Ph.D. received her Masters in Biology from the University of Illinois in 1979.
Posted June 14, 2016
return to top
Emad Tajkhorshid receives Department of Defense Multidisciplinary University Research Initiative grant
In all, the Department of Defense awarded 23 studies a total of $162 million over the next five years for experimentation and analysis. Selected studies will benefit one of the Army Research Office, the Air Force Office of Scientific Research, or the Office of Naval Research.
"Over the past 30 years, the DoD's MURI program has resulted in significant capabilities for our military forces and opened up entirely new lines of research," Melissa L. Flagg, deputy assistant secretary of defense for research, said in a press release. "Examples include advances in laser frequency combs that have become the gold standard in frequency control for precision in navigation and targeting; atomic and molecular self-assembly projects that have opened new possibilities for nano-manufacturing; and the field of spintronics, which emerged from a MURI award on magnetic materials and devices research."
LAS faculty receive Department of Defense grants
Posted June 12, 2016
return to top
Associate Professor Karen Sears Receives Two Prestigious Awards
Campus Teaching Excellence Award
LAS Award
Posted May 18, 2016
return to top
Graduate Student and Postdoctoral Fellowships
The School, and particularly the departments and labs, are proud of the awardees' accomplishments and would like to encourage incoming students and postdoctoral scholars to apply for these opportunities.
Ruth L. Kirschstein National Research Service Award (NRSA): Fellowships aim to enrich the research training of promising predoctoral students by providing individualized, mentored research experience. Applicants must propose an integrated research plan and a dissertation research project that meet the guidelines of the participating NIH Institutes and Centers. The NRSA award provides up to 6 years of support for research and clinical training including stipends, tuition and fees, and institutional allowance. The fellowship is designed to clearly enhance the individual's potential to develop into a productive, independent research or physician-scientist.
A Round of Applause for the School's Current and Recent NRSA Fellows!
Waqar Arif (Biochemistry, MD/PhD), Lily Mahapatra (Biochemistry), Shannon Walsh (Biochemistry), Matthew Biehl (MIP), Robin Holland (Micro), Itamar Livnat (MIP), Bernard Slater (MIP), Daniel Harris (Biochemistry), Paven Aujla (MIP), Sumanprava Giri (CDB)
American Heart Association (AHA) Fellowships are granted to help initiate careers in cardiovascular and stroke research by providing research assistance and training. Awardees devote their time to research or activities directly related to their development into independent researchers.
Congratulations to the School's Current AHA Fellows!
Donghyun Kim (MIP), AHA Postdoctoral Fellowship
Dennis Piehl (Biochemistry), AHA Predoctoral Fellowship
The Midwest Regional Chapter of the Society of Toxicology (MRC-SOT) provides an annual Young Investigator Award to individual research trainees in the area of the toxicological sciences. The purpose of the award is to ensure that an adequate number of highly trained scientists will be available to meet the future toxicology research needs. Young Investigator awardees will present the research at the following Annual Meeting of MRC-SOT.
Kirsten Eckstrum, from the department of Molecular and Integrative Physiology, received the 2015 Midwest RC Young Investigator Award at the 2015 Spring Meeting.
The Schlumberger Foundation Faculty for the Future Fellowship, which is awarded to women scientists and engineers from developing world to pursue postgraduate studies at leading universities worldwide. After completion of the study, individuals will return to their home countries where they will contribute to the development of science. In the 2015-2016 academic year, the Schlumberger Foundation awarded new fellowships to 155 women, and has also extended 135 existing grants.
Elizabeth Amosun, from Microbiology, received the Schlumberger Fellowship in 2015.
The Damon Runyon Research Foundation encourages all theoretical and experimental research relevant to the study of cancer including cancer causes, mechanisms, therapies and prevention. After successful completion of the fellowship, Damon Runyon Fellows are eligible to apply for the Dale F. Frey Award for Breakthrough Scientists, which provides additional support to exceptional Damon-Runyon Fellows.
Melanie Issigonis, a postdoctoral fellow in the Newmark Lab, received the Damon Runyon Cancer Research Foundation award in September of 2012.
Posted April 18, 2016
return to top
Prevalent but Under-studied Skin Infection Focus of New Research
Shisler, together with Dr. Brian Ward from the University of Rochester, will study the molluscum contagiosum virus (MCV) in detail to identify ways to regulate its underlying proteins to formulate cures for infections and diseases such as cancer.
According to the CDC, molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus; MCV). It is one of the most common skin infections in children and sexually active young adults. Despite this common infection, one major hurdle is that the virus cannot be propagated in cell culture. Most other viruses, such as herpes viruses, can be grown in cultured cells, making them easier to study. The goal of this research is to use new approaches to understand what barriers cells create to prevent virus replication.
Molluscum contagiosum (MC) is usually a benign though unsightly, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, molluscum contagiosum typically resolves without scarring but may take as long as 4 years and can be associated with stigma and the anxiety it produces.
In people with weakened immune systems (i.e., HIV-infected persons or persons being treated for cancer), these lesions can become much larger and persist indefinitely. Long-term effects include scarring and secondary infections caused by bacteria. Secondary infections may be a significant problem in immunocompromised patients, such as those with HIV/AIDS or those taking immunosuppressing drug therapies.
"Viruses are one of the most abundant microorganisms on the planet, infecting every form of life from humans to bacteria. However, these are the microbes that we understand the least. By understanding how viruses hijack the host cell, researchers can begin to answer fundamental questions about virology including how we can engineer new methods to detect and cure infectious viruses," said Shisler.
Posted January 11, 2016
return to top
Martha Gillette and collaborators receive two grants to study the brain
The work is facilitated by two grants that Gillette is a part of: the Emergent Behaviors of Integrated Cellular Systems (EBICS), which received $25 million in National Science Foundation (NSF) renewal funding for the next five years and the National Institute of Health (NIH) BRAIN Initiative grant which has received more than $2 million in funding over three years.
The goal of the EBICS project is to build living, multi-cellular machines to solve environmental, health, and security problems. These "biological machines" will serve as a basis to deliver drugs more effectively, function as internal diagnostic tools, or as contaminant sensors in the field. Gillette's group focuses on developing neuronal circuits to provide sensing and processing for the biological machines (biobots).
The (NIH) Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative works towards developing tools to characterize and analyze the brain at the cell and even subcellular levels to show how individual cells and neural circuits interact with each other in time and space. Gillette currently works in Beckman's NeuroTech Group and studies the brain's plastic responses to experience, investigating signals that shape and wire the nervous system.
Read more about the EBICS grant.
Read more about the BRAIN grant.
Posted January 05, 2016
return to top
Study identifies chemical in diet that determines a honey bee's caste
A closer look at how honey bee colonies determine which larvae will serve as workers and which will become queens reveals that a plant chemical, p-coumaric acid, plays a key role in the bees' developmental fate.
The study, reported in the journal Science Advances, shows that broad developmental changes occur when honey bee larvae – those fated to be workers – are switched from eating royal jelly (a glandular secretion) to a diet of jelly that includes honey and beebread (a type of processed pollen).
Beebread and honey contain p-coumaric acid, but royal jelly does not. Queens feed exclusively on royal jelly. Worker bees known as nurses feed the larvae according to the needs of the hive.
Experiments revealed that ingesting p-coumaric acid pushes the honey bee larvae down a different developmental pathway from those fed only royal jelly. Some genes, about a third of the honey bee genome, are upregulated and another third are downregulated, changing the landscape of proteins available to help fight disease or develop the bees' reproductive parts.
"Consuming the phytochemical p-coumaric acid, which is ubiquitous in beebread and honey, alters the expression of a whole suite of genes involved in caste determination," said University of Illinois entomology professor and department head May Berenbaum, who conducted the study with research scientist Wenfu Mao and cell and developmental biology professor Mary Schuler. "For years, people have wondered what components in royal jelly lead to queen development, but what might be more important is what isn't in royal jelly – plant chemicals that can interfere with development."
"While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant-insect interactions," Schuler said.
The USDA Agricultural and Food Research Initiative supported this research.
Story by Diana Yates, Life Sciences Editor, Illinois News Bureau
Photo by Terry Harrison, U. of I. beekeeper
Read the full article here.
Posted August 31, 2015
return to top
Ann Zielinski, MCB's Associate Director for Business Affairs, has been awarded the SPaRC Career Achievement Award.
Coming from a research background in Plant Physiology, Biochemistry and Endocrinology, Ann began her career at Illinois in the lab of I.C. "Gunny" Gunsalus, managing his research laboratory as well as his new endeavors as Assistant Secretary General of the United Nations. Over the years, Ann's math and financial abilities were quickly recognized and grant expenditure management was added to her responsibilities. Importantly, Ann has been responsible for MCB's performance in audits from the University, State and Federal agencies. She serves tirelessly on campus and college level administrative committees and is the 'go-to' person for advice and strategic vision. Her long-term dedication to excellence and high standards has served the School and Campus exceedingly well. "Ms. Zielinski is clearly an outstanding asset to the Illinois research enterprise," said Dr. Stephen Sligar, director of the School of Molecular and Cellular Biology. "Her long-term dedication to excellence and high standards has served the school and campus exceedingly well. Her service is most appropriately rewarded by receipt of the SPaRC Career Achievement Award." Sponsored Projects and Research Compliance (SPARC) is a comprehensive working group exclusively devoted to the management and administration of sponsored projects and open to all who wish to participate. SPaRC is supported by the Office of the Assistant Vice President for Business & Finance and the Office of the Vice Chancellor for Research. SPaRC Career Achievement Awards recognize professionals who have supported the field of research administration at Illinois for a minimum of ten years and have demonstrated a significant positive impact upon the support of Illinois research administration.
Posted August 24, 2015
return to top
Andrew Belmont: Influencing a generation of chromatin biology
As a postdoc studying chromosomal structure with David Agard and John Sedat in the late 1980s, Andrew Belmont had observed intriguing ultrastructural details in interphase nuclei. "We'd see large-scale fibers about 100 nanometers thick, and then there'd be a 10- to 30-nanometer-thick fiber looping out, which we thought might represent an active gene," says Belmont. "However, we couldn't rule out that these features were simply artifacts of fixation or sample preparation because we couldn't identify the region that we were looking at."
At the time, the only method available to identify a specific chromosomal region was in situ hybridization, in which a radioactive or fluorescently labeled nucleotide probe is annealed to complementary DNA or RNA sequences that have been denatured by chemicals or heat. The technique, first described in 1969, enabled major advances in cytogenetics and genomic mapping. But it wasn't suited to the application Belmont had in mind.
"One of the first experiments I did in my own lab was to perform a mock in situ hybridization and then take the sample to the electron microscope. I saw the chromatin structure was completely trashed at the ultrastructural level," recalls Belmont. His group needed a way to label specific chromatin structures in cells that also preserved DNA ultrastructure. The approach they devised was described in a 1996 paper published in JCB.
"It seemed like a crazy idea at the time, and I was concerned it wouldn't even work."
The paper unveiled a genetic construct containing 256 lac operator repeats that, once integrated into a cell's DNA, could be recognized by the lac repressor protein in both fixed and living cells. The site of lac repressor binding could then be visualized by indirect immunofluorescence or via fusion to the recently discovered green fluorescent protein. In mammalian cells, a single copy of the 256 repeat construct was sufficient to identify the site of its integration, which appeared under the light microscope as a tiny dot in the cell's nucleus. Importantly, however, amplification of the inserted repeat also granted insight into chromosomal structure.
"We showed that different amplified regions fold in characteristic patterns," notes Belmont. These patterns corresponded to whether the tag had integrated at open versus condensed chromosome regions. "We could observe large-scale chromatin fibers under a light microscope, then take them straight to the electron microscope and identify those fibers at the ultrastructural level by immunogold staining"—thus confirming that the large-scale chromatin fibers Belmont had previously seen in fixed extracted cells actually exist in live cells.
Finally, through collaboration with Andrew Murray's lab, the researchers showed that it was possible to insert a lac operator tag at a specific site in the yeast genome. This made it possible to follow dynamics of specific chromosomal loci in living cells.
Their approach was successful, but Belmont admits he's amazed it even got off the ground. "I kept outlining the project to prospective graduate students and no one would bite. It seemed like a crazy idea at the time, and I was concerned it wouldn't even work." It wasn't clear the lac repressor would recognize the operator motif once it was assembled on nucleosomes, or that repressor binding would be detectable by the fluorescent probes and microscope cameras then available.
"It is often the case that ideas that look good on paper totally fail when confronted with the reality of biology," agrees Carmen Robinett, first author on the paper. "Yet at every step, things just worked."
Belmont says the credit for that goes to Robinett. "I didn't even own a gel box at the time we began the work. I had no experience with any kind of recombinant DNA work, but Carmen basically came to the lab as a master's student, and planned and executed what in retrospect was a really difficult cloning project to make the lac operator repeat construct. She generated the cell lines containing amplified chromosome regions with the inserts, and even established Drosophila lines carrying the repeats. But then she had to leave the lab to start her PhD degree in Berkeley, and the project languished for a year or more before my department head, Rick Horwitz, rescued me with funding for a technician."
Belmont actually attributes his successful tenure application to this paper and the work it enabled, which includes investigations into fundamental questions about chromatin structure and localization.
Others have found it quite useful as well. "Their proof-of-principle application was inspirational," says former JCB Editor-in-Chief Tom Misteli. "It spawned an entire tool kit for tethering proteins to chromatin and for labeling, immobilizing and targeting chromatin regions. The system has generated insights into problems ranging from DNA repair and chromatin dynamics to gene positioning and nuclear body formation."
Original "From the Archive" article by Caitlin Sedwick, published in JCB here.
Read the 1996 article in JCB.
Posted August 12, 2015
return to top
Dr. Sligar, Director of the School of MCB, has been awarded the Herbert A. Sober Lectureship
Dr. Sligar's lab has been exploring how to reveal the structure and function of membrane proteins through the use of nanotechnology. Membrane proteins have been historically difficult to study due to many of the current biophysical and chemical techniques applicable to soluble enzymes failing to deal with insoluble aggregates. The emergence of nanotechnology could eliminate challenges faced by researchers during the solubilization of membrane proteins and allow for the study of membrane proteins from a mechanistic perspective. In this approach, the membrane protein target is transiently solubilized with a detergent in the presence of phospholipids and an encircling amphipathic helical protein belt, termed a membrane scaffold protein (MSP). The membrane protein then finds itself in a native membrane environment and is rendered soluble via the encircling MSP belt. The lab remains committed to the widest possible dissemination of the Nanodisc technology, including materials, methods and latest data from our laboratory. The Nanodisc system is now being used by hundreds of laboratories around the world that have realized great success and further advanced the technology. The American Society for Biochemistry and Molecular Biology (ASBMB) is a nonprofit scientific and educational organization with over 12,000 members. Founded in 1906, The Society's purpose is to advance the science of biochemistry and molecular biology through publication of scientific and educational journals. Dr Sligar's Lectureship award is given bi-annually and provides a plaque, honorarium and costs related to presenting a named lecture at the ASBMB Annual Meeting, which will be held in April. Dr. Sligar is the inventor of Nanodisc technology and currently holds the University of Illinois Swanlund Endowed Chair, the highest endowed position at the University. He is also the Director of the School of Molecular and Cellular Biology and is a professor of biochemistry, chemistry, and biophysics and computational biology and an affiliate of the Institute for Genomic Biology and the Micro and Nano Technology Laboratory. To learn more about the usage of the Nanodisc nanotechnology, visit www.BioNanoCon.com or Sligar Lab.
Read the ASBMB announcement article here.
Posted August 09, 2015
return to top


text: Frame by Frame: The 2013 Rose Parade People come from around the world to see the Tournament of Roses in Pasadena. Get more news and highlights from the Rose Parade on PasadenaSun.com. This photo gallery is featured in these articles: latimes.com Goodall on the Rose Parade wave, football and honoring the earth latimes.com La Cañada Flintridge float soars


text:
[caption id="attachment_6431" align="aligncenter" width="500" caption="Photo by @FortCampbell"][/caption]
A center opening is always a happy occasion for the USO. Today we opened the 142nd USO center worldwide in Ft. Campbell, KY, home to to the 101st Airborne "Screaming Eagles."
There were brand new shiny USO signs, the ever-popular cups of coffee, troops, families, community leaders, donors and a Huey. Yep, a Huey – right smack dab in the middle of USO Fort Campbell.
This helicopter was recovered from a scrap yard at ft Campbell in 2010. Thanks to the 159th combat brigade, Bravo Company 563D Aviation Support Battalion it's now the newest, coolest gaming station you'll ever see – and loaded with Xboxes and games thanks to Microsoft.
The 159th not only transported this helicopter, they also helped restore this UH1 Huey. Thanks to these soldiers, their labor of love will help lift the spirits of their fellow soldiers for years to come. - Gena Fitzgerald, USO VP of Communications
More from the USO
Jul 29, 2016
Military Bride-to-Be Says Yes to the Dress Thanks to the USO at Wright-Patterson Air Force Base
As soon as Melissa Wrisley put on the satin white gown, she knew it was "the dress." Just a few months earlier, when she was first engaged to her now-husband, Marine Pfc. Brandon Wrisley, Melissa was wondering if she would even be able to find a dress – let alone a designer dress – that would fit their tight wedding budget.


text:
Lindsey Dirden Overview
Lindsey Dirden is currently associated with one company, according to public records. The company was incorporated in Texas nine years ago.
Background + Contact Information Available for Lindsey Dirden
Contact + Background Information
- Phone, Address & Email
- Criminal & Civil Court Records
- Bankruptcies, Liens, & Judgments
- Properties, Businesses, Licenses, & More
Sponsored by PeopleSmartNo Thanks
Companies for Lindsey Dirden
Known Addresses for Lindsey Dirden
Other companies at ths same address
Texas Secretary of State
Data last refreshed on Monday, July 25, 2016
Data last refreshed on Monday, July 25, 2016


text:
Punta Gorda is a beautiful little city on the South west Coast. We are 3 hours from Miami to the South and Orlando to the North. We are trying to mantain small world charm with all the amenities. By the end of this year construction will start on the largest Solar Power Plant in the world - on our East. following that the first " All Solar Powered City" will be built in Babcock Ranch on the East side. "The Loop" the 1.5million square foot mall will be here. We have fine dining, golf, boating, fishing, dancing, kayaking, performance arts and almost everything you could want within driving distance. We don't really have beaches but we do have a few parks. There is always a lot to do here.
Visit my website for more on Punta Gorda. http://www.puntagordarealty.com
Good luck with your search.
Just 20 minutes north of Orlando, Lake County offers many different lifestyles. We have very rural, rural, as well as suburban areas. Lake County is located in Central Florida, we do have many beautiful lakes, however you do not have to reside on Lakefront property.
I have posted a link to my website, and to the County website also. Please visit them for a taste of Lake County.
Jimmy Williams
Coldwell Banker Tyre & Taylor Realty, Inc.
2765 S. Bay Street
Eustis, Fl 32726
If you do not like or need beaches or lakes, but prefer city style, you may wish to consider the charm and history of old St Augustine in NE Florida, you can view properties available at:
Or e-mail me and I can send you further information.
Harry Ashley
Broker Associate
Hawk Beach Realty
2 Jungle Hut Rd,
Palm Coast, Fl, 32137
Cell: (386)-931-6054
Fax: (866)-793-2579
Although Sarasota is on the Gulf coast and we have beautiful beaches, we're also considered the "Cultural Gem" in SW Florida. I recommend you take a look at my website. On the top right corner there is a quick video that may lend additional insight to our lifestyle.
If you would like additional info, please don't hesitate to make contact and I would be pleased to share Sarasota with you.
Good Luck!
Beth Lancaster


text:
City players have been told not to eat junk food as new manager Pep Guardiola tries to turn the team into Premier League champions again.
The 10th-ranked Canadians had several scoring chances in a match that could have gone either way.
Video of offensive, finger-jabbing bad behaviour being shown to players at English Premier League's 20 clubs ahead of new season as part of crackdown
The defending MLS MVP has struggled to find opportunities as Jozy Altidore's injury allows defences to focus on him
Video shows young boy comforting a fan of the opposing team after Portugal's historic victory.
Portugal won the 2016 European Championship, after substitute Eder scored in extra time to give his team a 1-0 win over France.
The record books will show that Portugal went from third-place in its group to champion, with little help from captain Cristiano Ronaldo, who was injured in the ninth minute.
At Euro 2004, a teenaged Ronaldo cried on the field in Lisbon after the host Portuguese team lost 1-0 to Greece.
Fan vote will likely lead to striker's inclusion on MLS all-star roster.
On Nov. 13, 2015, three explosions took place near the stadium, leading to four deaths, including the three suicide bombers.
Ronaldo is one of the greatest scorers of all time, but France has more depth.
Cristiano Ronaldo and Antoine Griezmann will meet for another title showdown when Portugal faces France in the European Championship final on Sunday, just six weeks after they contested the Champions League final.
France will play Portugal in Sunday's championship at Saint-Denis.
Battle of tournament's two outright favourites with World Cup defending champions against the hosts.
Plagued by scandal, trophy-less since 2000, Didier Deschamps says his team is poised to write its own history.
Portugal will next play France or Germany in Sunday's final at the Stade de France.
Real Madrid teammates Gareth Bale and Cristiano Ronaldo on opposing sides in unexpected matchup.
Portugal has been in the lead for a total of 22 minutes over the course of more than 8 hours of football in Euro 2016 so far, yet they're now one win away from the final in Paris.
Delivered daily to your inbox.
Young goalkeepers are going to make mistakes, Reds coach Greg Vanney said, and they deserve the opportunity to rectify them.
Italian striker scores three times against D.C. United in Toronto's 4-1 victory over D.C. United on Saturday night.
Striker needed Saturday against DC United at BMO Field to help a slumping Sebastian Giovinco.
A young group of players includes the like of striker Jordan Hamilton, 20, midfielder Jay Chapman, 22, and goalkeeper Alex Bono, 22.
Scarborough's Jordan Hamilton scored in the 64th minute to rally the Reds to a 1-1 draw.
The reigning MLS MVP has eight goals and seven assists, contributing to 79 per cent of the team's 19 goals
Leslieville diner closing to make way for condos.


text:
Jordan welcomes comedians Calise Hawkins and Monika Scott to the show for a fun romp through three new summertime malt beverages, a discussion of the personalities of flights around the US, and a rundown of Jordan's trip to Alaska. Show notes
Jordan, Jesse, Game!
Fan favorite Dave Holmes joins Jordan and Jesse for a discussion of educational tv shows, a cooking class Dave took, and Jesse's experience buying Simon a new bed.
OK it's a cake, not a pie but potato po-tah-toe


text:
IPL annual 'Ditch Your Fridge' program
Click here to see how the program works and how you can earn money.
Click here to see how the program works and how you can earn money.
A semi driver was jack knifed in the middle of I-65 Tuesday morning due to wet roads.
Anthony always follows the rules his dad thought him to avoid being a victim of crime
Dozens of people gathered Monday at the spot where Tyrone Powell was found dead.
Messel, 50, is charged with murder in the April 2014 beating death of 22-year-old Hannah Wilson, of Fishers.
Parmele admitted to taking the flags, and said he took them to the Veterans of Foreign Wars to give them a proper retirement.
"It is our goal to learn the facts and bring our systems completely back online as expeditiously as possible."
When Joe was thrown from the minivan, his organs were pushed into his abdominal cavity, and his diaphragm and pelvis broke.
You never know what you might find at an airport checkpoint.
"Today I begin a new chapter filled with personal hope and hope for others who have suffered genital injuries."


text:
Brooks House sold to local developersStaff Report | July 09,2013BRATTLEBORO -- The burned-out Brooks House, gutted during an April 2011 fire in downtown Brattleboro, has finally been sold to a group of local developers.
The long-awaited sale was consummated Monday said Bob Stevens, one of the principals of Mesabi LLC, the local group which will redevelop the local historic landmark.
Stevens said a formal groundbreaking will be held July 17 at 1 p.m., with Gov. Peter Shumlin on hand.
Total cost of the project is estimated at $24 million. Construction is expected to take a year.
The renovated Brooks House will have two anchor tenants in the form of the Community College of Vermont and the local campus of Vermont Technical College.MORE IN This Just InSPRINGFIELD Springfield residents will be asked next month during Market Madness for their... Full StoryPHILADELPHIA Many delegates from Vermont arrived at the Democratic National Convention this... Full StoryI could feel the groan rising inside me as I read the subject line of the press release in my... Full Story
- Most Popular
- Most Emailed


text:
Hello, Hello. Sign In
Please enter a valid city, state or zip code
32 reviews | 4.3 out of 5
Easy to assemble.
Easy to use computer module. Great feedback after finishing a ride:
Miles, Calories burned, Average heart rate, Average rpm, Average speed. This is my second stationary bike in my lifetime, the first also being a Schwinn.
The A10 is state of the art and I would recommend it to anyone. I am quite happy and satisfied with my purchase.
I have owned this exercise bike for around 5 months and find it to be a great bike. My son owns one of these as well. I have put around 800 miles on it and it is still going strong. It is quiet and compact - it fits in my loft without taking up a lot of space. I like that it has a little shelf where I can set my magazine or Kindle to read. It makes the time go by quickly. I like that I can use it and it doesn't disturb anyone who is watching tv in the same room. I highly recommend this product.
i never feel motivated to workout in the winter but when i got this bike it really helps because its really simple and fun to workout on this bike,i even put my laptop on top of the bike when i exercise to watch shows and other stuff its great! (im using this while typing =)
i gave it a 4 star because it took a while for me to assemble( the handles are hard to put together... and it was really heavy to carry upstairs!(because im doing this by myself.)
we needed a bike to help our son (10years old) with building endurance to help with physical therapy and my husband wanted to use it as well, this bike fits them both well. It's manufactured by nautilus which is what our physical therapist uses, works wonderfully and easy assembly. My only suggestion would be to have the plug adapter wired in the back vs front, but that's it. We ave a high end elliptical and this well matched for quality and we paid 2k for that . Buy this without hesitation, it's a great dealband we shopped around.
After having surgery, the doctor suggested that I use a excerise bike to build the strength back up in my legs. After checking out several bikes out I decided on the one. It wasn't to big and it had everthing I need on it. The only thing that I have found wrong with it is the seat. I am not a small person and the seat is unconfortable. But other than that it is an excellent bike. I have only had it for a week and I can tell the difference in my legs already. I have been riding for 10 minutes, 3 times a day. Not only am I building my legs up, I am also losing weight. You just can't beat is.
The bike seems like it is well built and solid. The seat is not very comfortable after a few minutes, but this is the only exercise bike I have used in years so I can't really compare it to any others. As others have said, the fan is useless. They must have added it to help persuade people to buy the bike. You can only notice it if you lean forward awkwardly and put your face close to it. The plastic wheels on the back stabilizer bar fall off way too easily. The information on the screen is hard to read unless you are in a bright area. Aside from those complaints, I am happy with it. It does what it is supposed to do. The seat height and handle bars are adjustable. My wife is 5'4" and is two holes up from the lowest setting, so it should be okay for someone around 4'10". The electronic tension adjustment is great as there is a large difference between the lowest and highest setting and about 7 different levels in between. I have seen reviews where people have said that the highest setting doesn't provide enough resistance. I have to strongly disagree with this. I have been jogging on the treadmill a few times a week for over a year so I'd like to think my legs are pretty strong, and I can easily say that the maximum resistance pushes back pretty good and gets that burn going. The bottle holder is a nice feature. So is the little raised shelf above the screen, plenty big enough to hold a 7 inch tablet computer. The bike is really quiet. I can listen to music or watch TV without having to turn it up really loud. There is a lot of competition in the $200 or less price level, but I get why this bike has gotten mostly positive reviews.
My wife and I got this bike to help get in shape. I am 6'1" and the bike fits me fine. My knees do not hit the handle bars, which I guess can be a problem for taller people on stationary bikes. My wife is 5'3" and has no problems fitting the bike either. The seat is pretty comfortable. I'm sure there are better ones out there, but for the price it's fine, and it's fairly wide, which helps with support (not a racing bike seat). The bike has several programs which are good too. I'm in pretty good shape already and although this bike has 8+ levels, I usually keep it around a level 3 or 4. It's magnetic resistance and gives a good workout! The one thing I wished this bike did would be to self-generate the electricity used for the magnets and the display. Unfortunately, it has to plug into the wall. It has a D cell battery option, but I just keep it plugged in. Well worth the $$ and you know you're getting quality with the name brand (schwinn). Oh, and I really like the pannel that is built into hold a book or tablet while working out. Although we only owned this bike for approximately 6 weeks, it gets a lot of use. My wife and I ride approx. 4 times a week each in 30-45 minute intervals. I hurt my knee a few weeks ago in a softball game, which has kept me off the bike for the last few weeks, but I'll be getting back on again in the next week or so. I'll update this review in the future if the bike suddenly breaks or stops working. So far, so good!
I would highly recommend this bike! At this price point it really fulfilled every expectation. Assembly: Very easy and took less than an hour at a leisurely pace. Display: It is a little hard to see and is not back-lit. Be sure to have this in an area with a decent amount of light or you will be squinting while setting up your routine! A/C Adapter: The display uses either D batteries or an A/C adapter. The instructions state that the A/C adapter is "optional" and needs to be purchased, but this was included in our box. The cord is a little short. Operation: It is extremely quiet. The first time it was used there was a clicking sound while peddling. If that happens to you, don't worry! For us that noise went away after the first 15 minutes of operation and we chalked it up to just the parts settling in for their first use. The only time you ever hear noise afterward is when it is changing resistance level during your routine. Seat: Starts to get a uncomfortable after 30 minutes. Fan: The only negative feature that they should have just left out. It is pretty much useless.
For the reasonable price, so far this has been a great bike. My only gripe is the seat. The seat was designed by an evil scientist to be used for torture. I've looked for replacements & have had zero luck. I even duct taped a throw pillow to the seat but it just felt like i was gonna fall off & that didn't last long. The bike seems to work great, no problems there at all but so far because of the terrible seat, it's turned into another coat-rack...
I am 77 yr. old 5'2" in excellent health - I tried and returned two other brand exercise bikes; one I needed a step stool to get on the bike and the other was a recumbent style and had to use books on the seat so my feet could reach pedals. This Schwill A10 is just right and would adjust in a few seconds, very easily, for a taller person. It is quiet, easy to get on/off, doesn't take up much room, seat is a little hard, but not too bad. Only fault is the workout monitor words/number are barely there and hard to read unless in a bright location - i use a flashlight to view the monitor and that works fine and fits into the cup holder on the bike. I definitely would recommend this for a workout cycle.
Met every expectation. Comfortable to ride and easy to use. Would recommend highly especially as it is a Schwinn. No adapters needed, everything is supplied.
I am big on reviews & is why I purchased this bike. I also thought Schwinn was a reliable product. For starters, the seat is uncomfortable, the built in fan is useless & my bike stopped working after 3 short weeks! Not at all satisfied with this product & for the price, I expected much more.
Easy to setup, good instructions, the tools provided could be better( wrench not very useful). Instructions were easy to follow. Like the size very compact, does not take up more than 6sqft.
Rides quietly, nice tension system, the screen could be brighter, hard to see sometimes.
Great buy for the price.
I love this Bike. I searched for many weeks before I found this one. I wanted one that was not too heavy so I would be able to position it myself (I am 5ft female, 71 yrs. old). I wanted it to be easy to reach the seat and wanted the handle bars to be close enough for me to reach without bending over. Met all my needs. My husband is very handy and had no trouble at all putting it together. It is a very good-looking bike. Very sturdy. Looks like a much more expensive bike.
I live in a NYC apartment so space was another consideration. It doesn't take up a lof of room.
Walmart delivered it in a few days.
I wasn't expecting such a nice bike for the amount of money I paid and was pleasantly surprised. I've used the bike twice (I've only had it three days) for 30 minutes each time. The bike is sturdy and the seat adjustment easy to change. The seat is surprisingly comfortable up to 20 minutes and then it's like any other seat, it starts to become uncomfortable. Not a criticism of the bike itself. I'm very happy so far with this bike and would definitely recommend it to a friend.
It seems Schwinn A10 sold now is an improvement from before. It's not shiny white. It's grey. Adapter is included. These two were the bases of negative reviews I read before i purchased it. All fixed. If the console doesn't work, make sure the cable is lined up ok. I had console problem at first. I took it apart the next day and made sure cable was not crimpled. Works fine now. Thanks to Walmart for selling the newer model.
After careful research, I finally settled on this exercise bike & am extremely happy with it!!!
Great bike for price, small footprint, compact and good workout for cheap!
The bike is very smooth and quiet. Between the pre-set programs and 8 resistance levels in
the manuel program, the choice of workouts is almost unlimited. With the manuel program,
you can bike at one level or make up your own program. The bike is comfortable to ride - I'm
5'2". The seat is fine for me - it's comparable to bikes I've ridden at the Senior Center.
It was easy to assemble with good directions. Its not difficult to move, but I wouldn't want
to haul it up a flight of stairs by my self. The one improvement it could use is a better fan,
but that's a minor item. A "would be nice" is a pair of flip-down wheels or casters on the front
strabilizer bar for moving. It's a really nice bike!
This is a great bike and went together pretty easy... I think it is well worth the money and does what I got it for, it is small and looks nice as well.


text: AdChoices Terms of Use Privacy Policy Hide VIDEO Sex and Dating Hairy Men Video Hairy Men Video AskWomen: Is Body Hair A Deal Breaker? AskMen Editors March 29, 2012 Share Tweet 0 Shares AskMen asks women. AskMen female editors answer user generated questions. In this video they discuss men's body hair. Where is it okay to have hair and how much? Hair Removal Attracting Women Dating Mistakes Love Advice Physical Attraction Comments Share your opinion Your name More Like This Dating Tips The Anatomy Of An Undateable Man - And What You Can Do About It Read More Sponsored Ad Content Learn How To Make Yourself More Attractive Read More Top 10 Dating Top 10: Ways To Become A More Attractive Guy Read More Dating Tips 5 Things You Need To Do If Your Parents Hate Your S.O. Read More Dating News Trending News: Here's Why Having Female Friends Makes You More Attractive Read More Dating Tips Signs You're More In Love Than She Is - Watch Out For These Before You Get Too Invested Read More Around the Web Special Features Guy Gear The Best Watches Under $500 Read More Special Feature The Ultimate Guide To Hooking Up Online Read More


text:
All quotes tagged Beauty
(3091 quotes found)
"The pursuit of truth and beauty is a sphere of activity in which we are permitted to remain children all our lives."
"Remember if you marry for beauty, thou bindest thyself all thy life for that which perchance, will neither last nor please thee one year: and when thou hast it, it will be to thee of no price at all."
"Sometimes the beauty is easy. Sometimes you don't have to try at all. Sometimes you can hear the wind blow in a handshake. Sometimes there's poetry written right on the bathroom wall."
"Imperfection is beauty. Madness is genius and it is better to be absolutely ridiculous then absolutly boring."
"I pull you from your tower, take away your pain. Show you all the beauty you possess, if you only let yourself believe."
"Education is the best friend. An educated person is respected everywhere. Education beats the beauty and the youth."
"To dream anything that you want to dream. That's the beauty of the human mind. To do anything that you want to do. That is the strength of the human will. To trust yourself to test your limits. That is the courage to succeed."


text:
We stayed here for our honeymoon and we loved it. On Expedia it said it was in the French Quarter but is it across the street of Canal so not really in the FQ but 15 min. walk to Bourbon and Canal. Nice and close to Harrah's, the Riverwalk and the St. Charles Trolley. The free breakfast is very convenient, good, changes up every day and we only ate out for breakfast one morning, there was a guy who was in the breakfast room (wish I could remember his name) he was super friendly and sang a lot. The staff at the hotel were awesome, greeting us every time when we came back and told us to have a good day when we left. The room was nice, very comfortable bed, great pillows. The only bad thing was they gave us a room right next to the elevator and it did wake me up some mornings. I had emailed them to tell them we were on our honeymoon and asked for a nice room with a view and we got a room with a view of a building and next to the elevator, oh well. We were on our honeymoon and nothing was going to ruin our vacation. The pool in the Courtyard is a dipping pool (small) but the area is very nice and we went down a couple of nights to dip in the pool and no one else was around, had it to ourselves. We walked everywhere even to the French Market which is on the other end of the French Quarter.
- Official Description (provided by the hotel):
- With its home-like decor and plentiful amenities, the Country Inn & Suites, New Orleans French Quarter offers comfort and convenience in the heart of downtown New Orleans. Our historic hotel is comprised of seven 19th century buildings, giving it a charming, boutique feel that artfully blends old world charm with modern comforts. Our prime location on Magazine Street near the French Quarter places our guests close to many nearby New Orleans activities and attractions, including Bourbon Street and the Convention Center. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Hotwire, BookIt.com, Hotels.com, Travelocity, Odigeo, Carlson, Cheap Tickets, TripOnline SA, Cancelon and Expedia so you can book your Country Inn & Suites By Carlson, New Orleans French Quarter reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Country Inn & Suites New Orleans Hotel New Orleans
- Country Inn And Suites New Orleans
- Country Inn New Orleans
- New Orleans Country Inn


text:
Mmm, 2,000-year-old pickled fish ... my mouth is watering ... (not):
Cosmic LogShared publicly -
Very cool find. I am always impressed how our ancestors were able to achieve what we consider very "modern" conveniences hundreds if not thousands of years ago.
OMG! I have to read this! I wonder if they have any garum still safe to eat? It's the Roman precursor to Worcestershire sauce.
Add a comment...


text:
What does 'Exposure At Default - EAD' mean
Exposure at default (EAD) is the total value that a bank is exposed to at the time of a loan's default. Using the internal ratings board (IRB) approach, financial institutions often use their own risk management default models to calculate their respective EAD systems. Exposure at default, along with loss given default (LGD) and probability of default (PD), is used to calculate the credit risk capital of financial institutions.
BREAKING DOWN 'Exposure At Default - EAD'EAD is the expected amount of loss a bank may be exposed to when a debtor defaults on a loan. Banks often calculate an EAD value for each loan and use the figures to determine their overall default risk.
Probability of Default Analysis
Probability of default (PD) analysis is a method used by larger institutions when calculating expected loss. A PD is already assigned to each risk measure and represents the percentage expectation for default, typically measured by assessing past-due loans. Loss given default (LGD), unique to the industry or segment, measures the expected loss, net of recoveries, expressed as a percentage.
Calculating Expected Loss
When combined with the variable EAD or current balance at default, the expected loss calculation is expressed in the following formula: Expected Loss = EAD x PD x LGD. PD is typically calculated by running a migration analysis of similarly rated loans over a specific time frame and measuring the percentage of loans that default. The PD is then assigned to the risk level. Each risk level has one PD percentage.
An accurate LGD variable may be difficult to determine if portfolio losses differ from what was expected or if the segment is statistically small. Industry LGDs are typically available from third-party lenders. In addition, PD and LGD numbers are typically valid throughout an economic cycle. However, the numbers should be reevaluated periodically or in the event of economic recovery or recession, merger or significant changes in portfolio composition.
Example of Exposure at Default
In June 2016, the House of Representatives passed a bill helping Puerto Rico restructure its $70 billion debt load in an attempt to avoid defaulting on more of its debt payments. Rather than providing direct financial assistance, the bill established a seven-person advisory board that is responsible for negotiating with the island's creditors to avoid a potentially long, expensive court battle. The bill also created a federal task force responsible for finding ways that Puerto Rico can get out of the economic challenges it has been experiencing for decades.
Part of the reason for the collapse was Congress' 1996 decision to end a tax break that led U.S. pharmaceutical and petrochemical companies to establish subsidiaries in Puerto Rico. When the tax break ended, companies began leaving the island.
Loss Given Default - LGDThe amount of funds that is lost by a bank or other financial ...
Credit Default ContractSecurity with a risk level and pricing based on the risk of credit ...
Temporary DefaultA bond rating that suggests the issuer might not make all of ...
Strategic DefaultA deliberate default by a borrower. As the name implies, a strategic ...
Default1. The failure to promptly pay interest or principal when due. ...
Default RiskThe event in which companies or individuals will be unable to ...
Personal Finance
Understanding Default RiskDefault risk is the chance that companies or individuals will be unable to pay their debts.
Calculating (Small) Company Credit RiskDetermining creditworthiness of smaller and medium-sized corporations isn't as easy as for larger companies, but these tips can help.
What Happens in a Default?Borrowers are in default when they don't honor a debt, whether their failure is intentional or not.
Puerto Rico Probably Will Default on More Than $1B FridayPuerto Rico's debt problems have been piling up, and many have gone so far as to call the island America's Greece.
How Credit Rating Risk Affects Corporate BondsCredit migration risk is a vital part of the credit risk assessment, specifically with regard to corporate bonds which underlie numerous rating changes.
Junk BondFind out more about these bonds that have a high risk of default.
ETFs & Mutual Funds
High-Yield Bond ETFs: 3 Reasons to Avoid ThemExamine high-yield bond performance in 2016. Why do rising default rates, falling recovery rates and Fed rate hikes make these securities worth avoiding?
Emerging Market Defaults: Beware of Second WaveEmerging market corporate defaults have the potential to be the biggest risk to global markets.
Supreme Court Tosses Puerto Rico's Recovery ActThe U.S. Supreme Court has ruled against Puerto Rico's debt restructuring law, leaving the territory few options in the face of debt payments due in July.
Puerto Rico Will Soon Become America's GreeceExplore the similarities that exist between Puerto Rico in relation to the United States and Greece in relation to the European Union.
What factors are taken into account to quantify credit risk?Learn how probability of default, or PD; loss given default, or LGD; and exposure at default, or EAD, are used to help quantify ... Read Answer >>
What level of default rate is typical for the credit services industry?Learn how default rates affect businesses in the credit services industry, and what rates are considered normal for a company ... Read Answer >>
In the beginning of this year, the total par value of all CCC-rated bonds were $12 ...The correct answer is: d) (i) Default Loss Rate = [($1.3 billion - $625 million)/$1.3 billion] = 51.9% (ii) Dollar Default ... Read Answer >>
In what types of financial situations would credit spread risk be applied instead ...Find out when credit risk is realized as spread risk and when it is realized as default risk, and learn why market participants ... Read Answer >>
What special powers does the government have to collect student loans?Contact student loan companies before student loans default, as the government has the power to get its money. Prior to default, ... Read Answer >>
What is the difference between student loan default and delinquency?Learn the differences between simply becoming delinquent on your student loans vs. actually defaulting on your student loan ... Read Answer >>


text:
Track using Order ID
Login and do more!
- Track individual Orders
- View your entire Order history
- Cancel individual Orders
- Conveniently review products and sellers
I got introduced to Haruki through a friend of mine who absolutely swears by his books. Norwegian Wood is the second book that i read of this author. Savoured this book lil by lil so as not to finish it too soon. But the final part of the book was the best one. At the end of the book, I felt like I have experienced "life" in its entirety through this book. The various fallacies of human nature, the contradictions that are constant in our minds are brilliantly portrayed in this book. Though what you get out of this book is entirely personal and relative and depends how you can relate to your experiences in life.
Reading such a novel is an experience that no one should deny oneself.
This is one of Murakami's best works. It was profoundly deep and touching. I could relate to every emotion described, and the feelings of every character was intense.
There was the usual Murakami's Metophoric touch to it. The book leaves you with lingering thoughts which just becomes a part of you.
A must read!
i started reading this book , after a few pages i stopped reading,
instead , ended up living the book.
the protagonist's character is one which everyone could relate to.
the varying degrees to which the three main characters , take life seriously , is beautifully etched.
the magical metaphors used , metamorphose into stunning and seductive scenes in your mind.
there's something in this book for everyone and everything in this book makes you think of that special someone !
This was my first book by Haruki Murakami, and I loved it through and through. It's awesome, evocative, fabulous, beautiful, ... I'll fall short of words in praising the book. In short it's one of the best books I've read.
This is a sheer beauty by Murakami. It's a tranquil journey of a Japanese teen, involving lots of patience and realizations.
You are automatically teleported to follow the story. A must read.
A nice read. I could relate to every emotion described, and the feelings of every character was intense. But in between I felt that in between the story was moved to some other way which exaggerate the story.
This is a love story....but behind the veil of a love story there is a deeper author asks a deeper question. What is really the boundary between the sane and the insane. He goes on to show that it is indeed not clear and distinct just as the boundary between reality and imagination and theme which percolates all of literature.
its very rare that one finds such a book..i got to know about this book by chance..once i started to read it..i found it strange..but i couldn't put down the book..it was so gripping..the emotions felt by the characters are surreal..takes us into a nostalgic walk through someone else's eyes..like a dream..it captures us..
this is the first book that i read of Murakami.. truly remarkable..
this was my first Murakami read and i was intrigued right from the first page. a simple story is made brilliant by the author's skill of telling a story in a daring manner. post-colonial in tone, with an ordinary college boy as the hero without any heroic attributes, the minute details of the simple lives and events told with rare boldness make it an interesting read.most of all, the 'one-of-a-kind' narrative style deserves appreciation.
This is how goes starting lines of "Norwegian Wood" .This is my first Murakami book......and boy did I loved it!!! The fact that "Norwegian Wood" is also one of my favorite song made it icing on the cake.
Sometimes you may wonder why people read such type of stuff but then I know the answer if not these type of books then which ones we will read? Absolutely a must read for all especially young males this book catches all the emotions of young and restless mind.I can't wait to read all other Murakami's Work!!!