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Located in Tokyo (Iidabashi), Tokyo Garden Palace is minutes from Origami Kaikan and Japan Football Museum. This hotel is close to Tokyo Imperial Palace and Sensoji Temple.
Make yourself at home in one of the 213 air-conditioned guestrooms. Complimentary wired and wireless Internet access keeps you connected, and cable programming provides entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include phones, as well as safes and desks.
Satisfy your appetite at one of the hotel's 2 restaurants. Breakfast is available for a fee.
Business, Other Amenities
Featured amenities include complimentary high-speed (wired) Internet access and complimentary newspapers in the lobby.

subset: commoncrawl


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The My Little Pony Friendship is Magic Zoom 'n Go Rainbow Dash from Hasbro is part of the new Rainbow Power line. The 3.5-inch figure features Rainbow Dash's signature cutie mark, brightly colored rainbow mane, and a set of fluttering wings. It also comes with an attachable hat and cart. While directions are not provided about the zoom 'n go feature of this toy, it's pretty simple to figure out. The figure features a wheel on its belly so when you fold Rainbow Dash's legs out you can move the figure along the ground as a push-along toy. As you roll Rainbow Dash forward and backward, it activates its wings and makes them flutter as if Rainbow Dash was flying. Attach the cart to Rainbow Dash's right hind leg like a side car.
My Little Pony Fans will appreciate the detailing on this figure, which does a good job of staying true to the look of the character in the animated series. The push-along feature also offers additional opportunities for fans to roleplay with Rainbow Dash and act out the flying skills she's known for on the show.
My Little Pony Friendship is Magic Zoom 'n Go Rainbow Dash is for Pony fans ages 3 and up.
Directions for this toy are not included. However, kids will find the play intuitive.
Project Mc2 Camryn Coyle
from MGA Entertainment
Project Mc2 Adrienne Attoms
from MGA Entertainment
Barbie Crimp & Color Deluxe Styling Head
from Just Play
Littlest Pet Shop Pet Shop
from Hasbro
Project Mc2 Bryden Bandweth Smiley Face Shirt
from MGA Entertainment
Project Mc2 Bryden Bandweth Sharpest Pencil Shirt
from MGA Entertainment
DC Super Hero Girls Power Action Wonder Woman Doll
from Mattel
Monster High Dance the Fright Away Playset
from Mattel
Monster High Voltageous Hair Frankie Stein
from Mattel
Disney Princess Mini Toddler Aurora
from Jakks Pacific


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Autism Speaks and MLB team up to raise funds, awareness
Autism Speaks and Major League Baseball (MLB) teamed up for a very special gala at The Metropolitan Museum of Art benefiting people and families affected by autism spectrum disorder.
Local Events
August 03, 2016
Paint For A Cause with Autism Speaks! Wednesday, August 3rd 7:00-9:00 PM Details: Get creative & have fun,all for a great cause. You will be contributing to raising More...
August 06, 2016
Upcoming Walks
Saturday, August 20, 2016
Saturday, September 10, 2016
Sunday, September 11, 2016
Sunday, September 18, 2016
Saturday, September 24, 2016
Saturday, September 24, 2016
Saturday, October 1, 2016
Saturday, October 1, 2016
Saturday, October 1, 2016
Saturday, October 1, 2016
Sunday, October 2, 2016
Saturday, October 8, 2016
Saturday, October 8, 2016
Sunday, October 9, 2016
Saturday, October 15, 2016
Saturday, October 15, 2016
Event Recaps
The 2016 Richmond Autism Speaks Walk Kick Off & Awards at Maggiano's Little Italy in Richmond, VA was a huge success. This event on June 12th recognized top teams More...
Neil Young, The Rides (featuring Stephen Stills, Kenny Wayne Shepherd, and Barry Goldberg), Jakob Dylan, The War On Drugs, Nikka Costa, Chris Stills and emcee Jack Black, More...
More than 15,000 attendees participated in Autism Speaks Georgia Walk in Partnership with the Marcus Autism Center on May 1, 2016 at the Turner Field – Green Lot. The More...
On Sunday the New York a Mets hosted their annual Autism Awareness Game. Families braved the rain to take part in the pre-game festivities hosted by Autism Speaks and other More...


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Hansen faces a dozen in Gotham
- By
- Handicapping
Juvenile colt champion Hansen, who suffered his first career defeat in the Grade 3 Holy Bull on January 29, will attempt to get back on the winning track in Saturday's Grade 3, $400,000 Gotham at Aqueduct. The front-running gray has not scared away the competition, as he will break from post 12 in a field of 13 going 1 1/16 miles on the inner dirt. This is the final local prep for the Grade 1 Wood Memorial on April 7.


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Skip to comments.Woman punches out McD's drive-thru window over McNuggets
Posted on 01/04/2010 10:37:56 AM PST by reaganrevolutionin2010
A Toledo woman, who allegedly put her fist through a fast-food drive-through window after being told her order couldn't be filled, appeared in court Saturday on a felony vandalism charge.
Melodi Dushane, 24, of 1332 Felt St. became "upset that chicken nuggets weren't available" and "punched out the drive-through window," according to Toledo police.
Police were called Friday to the McDonald's restaurant at 90 Main St., where Ms. Dushane was arrested.
Before Ms. Dushane was booked into the Lucas County jail, she was treated at Mercy St. Charles Hospital for injuries sustained when she allegedly punched at the window.
Ms. Dushane pleaded not guilty to the charge yesterday in Toledo Municipal Court.
(Excerpt) Read more at toledoblade.com ...
Obama voter.
I'd ask Laz if he'd hit it... but she'd likely hit him first...
It must be something in the water. Seems the whole world has gone goofy.
I don't think the HOT COFFEE DEFENSE will work with this one.
"Dushane, 24, of 1332 Felt St. became "upset that chicken nuggets weren't available" and "punched out the drive-through window," according to Toledo police."
There was another story like this a couple months back where a woman called 911 when she couldn't get some of these at the counter. What's happening here? Do these things contain crack?
I bet alcohol was involved or maybe autism.
I disagree,
NOT Guilty.
Especially a pretty blond girl who can put her fist through a window.
Who's gonna tell her she's guilty?
Not me!
Especially a pretty blond girl who can put her fist through a window.
Doesn't seem to be a real blonde to me! :>)
No, she called 911 when she paid for them, then was told they were not available and they would not refund her money. She called the police for theft, not for no McNuggets.
Wonder if she gets that mad over abortions. (probably if they fail).
I hereby endorse a Public Option for McNuggets which will involve deficit-neutral funding. Pre-existing orders for extra sauces will be free.
"they would not refund her money."
Now that is really odd if that is true. Wasn't there a senior acne covered kid on duty to make that big time executive decision. ;-)
Doesnt seem to be a real blonde to me! :>)
Doesn't seem to be real pretty either.
Guilty, stupid and an Obama voter.
What a trifecta!
She should have asked the operator for the number for the local police and not used 911, but yeah, that's what happened.
She paid, they came back and told her that they were out, she asked for her money back and the manager said that it wasn't policy to give money back and she had to pick something else off the menu. So she called the police.
And somehow she became the new "they won't make me a western bacon burger" lady who called 911.
Mug shots are never pretty.
I bet she cleans up real nice, though.
Just don't take her on a date to McDonald's.
THEN I'd hit it.
that was a joke.
I forgot to use a tag.
When its time for a crackhead to eat, they wanna eat dammit.
Fisting - taken to a new dimension.
Laz doesn't offer refunds if he can't fill the order?
"I bet alcohol was involved or maybe autism."
Alcohol and/or drugs.
Methamphetamine comes to mind.
Hey! At least it's a step up from calling 911! LOL!
Thought so, almost asked.
Stupid, but I have had the same urge at times, for instance going to Arby's and they are out of roast beef in the middle of the day or a local chain that serves a beef-onion-cabbage combo baked in a small bread roll called a runza (their signature product and the name of the chain) and they are out of runzas.
Either 'girls just wanna have fun' or blondie had a PMS beechie episode. Did she at least get a rain check on those McNugs?
Whammy Burgers rule....but a whammy shake sucks.
Zwho knows...it could be that she didn't "punch" the window, but was pounding on window demanding her money back.
Sounds like a new psychological disorder is emerging—McNugget Derangement Syndrome (MDS).
In our town, you have to call 911 for everything. They don't even have a number for the local police. You have to call 911.
IIRC, MacDonalds changed their corporate policy so that they had to give cash refunds if they couldn't honor an order.
She was one of the last customers that night and they didn't want to make a (small) batch just for her.
My guess was meth
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Crazy Substitute Teachers
Enjoy, NG4.03 / 5.00 1,288 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner3.97 / 5.00 2,362 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.88 / 5.00 3,314 Views
you made that up on the spot didnt you ............ best story ever!!!!!!!!!111oneeleven
Wow! This is the first time I've heard someone else pronounce all the names and places in LoZ: OoT exactly how I always have! That alone I give you a 10 in proper pronunciation! ^_^! The movie itself was very well done. It looks like you put a lot of heart into this and I commend you for that! The humor was cute, and graphics and style were excellent, and the sound and choice of music was superb. I hope you continue to make great movies like this! Never let the bad reviews of others get you down!
Awesome, but what to expect with..
Of course it's awesome, this is alex l'abbe we're talking about! His FFX parody killed ass. By the way, Link's voice was...ugh..I hated it no offense. But nice anyways. Best flash i've seen in a while.
Where's the weak spot now?!
Funny stuff. Good voice acting too. But I kinda wanted to see the other characters: like the chic from Lon-Lon Ranch and... and the chic from Lon-Lon Ranch.
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MATLAB for Selective Harmonic Elimination for three-phase and five-phase VSI
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How to delete synced photos and folder from iPhone, my OS is Windows 7 and I don't want to erase all content from setting.
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Friday Clips 4/17/09
April 17, 2009 · Print This Article
Am I alone in thinking that whole Susan Boyle thing was a setup? Everyone's "surprise faces" looked sort of fake to me. ANYWAY, here's an otherwise Boyle-free, purely subjective round-up of art-world events, news stories, blog links and other stuff in Chicago and beyond that got me thinkin' this week….
* Literary theorist Eve Kosofsky Sedgwick dies of breast cancer at 58 (New York Times Obit.).
*In latest round of filings, Shephard Fairey turns tables on AP, accuses news organization of copyright violation. (Culture Monster).
*Ellsworth Kelly to install "White Curve," his largest wall sculpture to date, in the Art Institute's new Modern wing next week. The Art Institute will also add Kellys' "Tableau Vert" (a gift from the artist) and "Red Diagonal" (gift of Chicago collectors Howard and Donna Stone) to its collection (New York Times).
*"Class Pictures: Photographs by Dawoud Bey" opens at Milwaukee Art Museum.
*Gearing up for Art Chicago: Buckminster Fuller's Fly's Eye dome now on view at Merchandise Mart (no admission fee required). (The Skyline).
*Skip this page: a retrospective of Rhizome's splash page internet art now on view at Rhizome.org. (Art Fag City has a typically thoughtful review of it here).
*Across the board, museums face worsening crises. Artinfo.com has created a handy timeline of Museums and the recession (this last via Art21 blog; but, as blogger Kelly Shindler points out, the stats in the timeline need verification).
*Another walk-in pantry at Chicago's mini dutch takes place this Sunday from 12-3 (email Lucia to let her know you're coming). BYOB, $3 donation. What's on the menu? Quiche!
*All four seasons of PBS series Art21: Art in the 21st Century can now be viewed on Hulu. Also free for the grabbin': The Tate's media library on iTunesU.
*More "free" stuff: Sweepstakes contest for Damien Hirst lithos and "the chance" to win his original album cover painting for The Hours (via Animal). Now point me in the direction of the Ayn Rand compound, please.
What We're Doing This Weekend 4.17-4.19
April 17, 2009 · Print This Article
Luke Dowd: Happy Happy Sad Sad
April 17 – May 30, 2009
Tony Wight Gallery
119 North Peoria Street, #2C
Chicago, IL Â 60607
Tuesday – Saturday, 11 – 5 pm
from the press release:
"London-based artist Luke Dowd's patterned depictions of diamonds engage the volatility embedded within notions of value. Using screen-printing as gesture, Dowd creates subtle gradients which imbue his images with a faux luster mimicking the qualities of actual gemstones. These painted diamonds appear to reflect and refract light, just like the real thing, pointing towards the sheen of high culture and status, both implicit and inseparable from the value system to which we collectively subscribe. However, these images are also able to extend beyond the role of pure representation, as they address the fictional nature inherent to our conceptions of value."
Also opening at Tony Wight: Olio
April 17 – May 30, 2009
From the press release:
"The title of the exhibition makes reference not only to the heterogeneity inherent to the medium of collage, but also the heterogeneous nature of group exhibitions. Included in the show are works by Tamar Halpern, Pablo Helguera, Arturo Herrera, Shinique Smith, John Sparagana and Dannielle Tegeder.
Since its appearance in the Synthetic Cubism of Picasso and Braque, through the Neo-Dadaist assemblages of the late Robert Rauschenberg, the collage impulse has provided both an immediacy and malleability which has been frequently engaged and reinterpreted in subsequent generations. While the works in Olio are not necessarily pointed homages to earlier collage, they are each forthcoming in their indebtedness to the medium. By feeding common or popular imagery through various procedures—cutting, pasting, scanning, layering—these artists complicate the immediacy of their original materials. The resulting artworks skew our normative reception of otherwise familiar images."
Version Fest Fundraiser at Country Club Chicago
April 17th, 2009
1110 N Damen
Chicago, IL 60622
A raffle/auction party to raise funds for the 8th annual Version Fest.
Buckminster Fuller: Starting with the Universe
March 14 – June 21, 2009
220 East Chicago Avenue
Chicago, IL
From the website:
"A man of remarkable prescience, Fuller's credo was "more for less," and by the late 1920s he recognized the need for environmentally sound design that would benefit the largest segment of society while using the fewest resources — a decidedly contemporary concern. Believing in the interconnectedness of all things, Fuller's ambition in life was to close the gap between the sciences and humanities for the genuine good of humankind. His work has extensively influenced the artists, designers, architects, engineers, environmentalists, and mathematicians of today."
Opening night film: Salt of this Sea (Milh Hadha Al-Bahr)
8:00 pm
Gene Siskel Film Center
164 North State Street
Chicago, Illinois 60601
Part of the Chicago Palestine Film Festival, which starts on Saturday and runs through April 30th, director Annemarie Jacir will be at this screening to engage in a discussion after the film.
From the website:
"In part a road movie, the story follows American-born Soraya (Hammad) from her contentious entry into Israel to reclaim her grandfather's bank account, through stolen days of freedom on a trip to Ramallah, where the reality of her family's missing legacy sets in. Soraya's determination to assume a Palestinian identity and history finds an ironic counterpoint in the resolve of her Palestinian-born new lover Emad (Bakri of THE BAND'S VISIT), to leave it all behind."
That's It, I'm out of here
April 16, 2009 · Print This Article
Bad at Sports has realized that society is doomed and is now accepting applications for it's Ayn Randian compound in the mountains where we will build a new society cleansed of the truly icky.
This week, the Art-School Grad Student who's sleeping around: 26, female, Upper East Side, straight, single.
1:50 a.m.: Making out with Tattoo Guy. Have bad spins. Tell him I need water and to sober up before hooking up again. He gives me a line of his own stuff.
10 a.m.: Know this is going to be one hell of week as feeling in love with Tattoo Guy, and now super-depressed. Make appointment with school shrink.
11:30 p.m.: In bathroom, I notice prescription bottle. Shouldn't look, but who wouldn't? Suddenly sick-feeling. Valtrex. Shit. Could I have contracted from five-minute intercourse with condom?
BAS Giveaway: The Wizard's Hat
April 15, 2009 · Print This Article
The kind folks across the pond at The Wizard's Hat sent me two copies of Issue 03 (The Magic Number) of their illustration zine to give away. "The Wizard's Hat is an illustration house & zine created by Jeffrey Bowman and Andy.J Miller as the platform for producing collaborative projects under one name. The house focuses itself on self initiated projects involving many of today's most established illustrators as well as producing its own body of projects based on their love of illustration.â€
Illustrations By:
Jim Stoten, Olimpia Zagnoli, Gemma Correll, Will Bryant, Nick Deakin, Nousvous, Robert Loeber, MrGauky, James Gulliver Hancock, C86, HeyHeyHey, Zeptonn vs. Welmoet, Kipi Ka Popo, Edward McGowan, Ashkahn Shahparnia, John Ringhofer, Andy J.Miller, Jeffrey Bowman
Music By:
John Ringhofer, Half Handed Cloud, Jim Stoten, Jimtheillustrator, Andy J.Miller, 'Ponstinople Clones' feat Nick Philpin
Hit me up if you want a copy. First two people will get one.
Seth Price at Light Industry
April 14, 2009 · Print This Article
Something tells me that when Jerry Saltz said, "It's a cool school, admired by jargon-wielding academics who write barely readable rhetoric explaining why looking at next to nothing is good for you." He meant something like this:
From the Press Release for Transfers:
Untitled, a 16-millimeter film first screened as part of an exhibition at the Friedrich Petzel Gallery in 2006, emerged from Price's observation that abstraction was rarely seen in film or video presented in art-world settings, despite a strong tradition in experimental film in general. Price purchased a 6-second video loop from a company that makes "empty" background images for corporate use, then added color effects, looped it, and transferred it to film, yielding a hypnotic, emptied-out work that looks back to structuralist and early film experiments even as it presents an image of degraded and détourned digital junk, threatening at each instant to collapse into compression artifacts.
Perhaps out of stubbornness, I still plan to attend. Although it's an intriguing proposition that we'll see less of this type of work rather than more.
Brooklyn, New York


text:
Local Vibes at Jada Coles on the Happy Hour Hunt
Jada Coles
2224 Coral Way, Miami
305-456-9242/ jadacoles.com
The Deal: Monday-Friday, 4 p.m. to 7 p.m., half off everything
Located directly on Coral Way right off 22nd Avenue, Jada Coles blends just enough comfort to be deemed "laid back" with just enough quirkiness to be deemed charming. Couches are nooked towards the front of the space, while mix and minglers can sit at the high tops next to the pool table or float around the bar. Coles' small size makes for a friendly environment; it's the kind of place where the bartender chats you up about the Yankees/Red Sox rivalry and fellow drinkers introduce themselves without being creepy. The music jumps from Counting Crows to Fifty Cent.
Jada Coles' happy hour includes half off everything, meaning a Jack & Coke is only $4 and a Heineken is $3. Their menu has recently changed and has not been printed, but the bartender insists they will keep some of their previous Mexican specials.
Hang out until later in the evening and catch karaoke on Mondays, comedy on Tuesdays, or live music on Fridays. Sneakers, caps, and good local vibes are all welcome.
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In This Section
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AES E-Library
The Development and Design of a Flat Diaphragm, Printed Ribbon Microphone Capsule
The paper outlines the development of a new microphone diaphragm and energizing system which produces high output with low distortion, while eliminating the use of power supplies and internal amplifiers. This new design technique utilizes a flat diaphragm with a flat etched ribbon coil, energized via a powerful Sumarium-cobalt magnet system. The paper describes the performance characteristics, manufacturing methods and the application of the microphone capsule to various microphone types.
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Blair Atholl, Perthshire, Scotland Show on map
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Georgia used to be one of 16 states that had enacted some sort of exemption to workers' compensation coverage for farm or agricultural laborers. Now, it's one of just 15 states, after the New Mexico Supreme Court handed down a ruling striking workers' compensation exemptions for farms and ranches as unconstitutional.
The case is Rodriguez v. Brand West Dairy, and the decision casts uncertainty as to the future of the law in Georgia and other states. To be clear: This decision won't immediately impact Georgia workers. Because each state is in charge of handling its own workers' compensation system, a conflict between states on an issue like this isn't likely to be appealed to the U.S. Supreme Court. Nonetheless, a ruling of this nature by a sister court is one that could open the door for a similar challenge here in Georgia.
According to court records, the New Mexico Workers' Compensation Act, since its inception in 1917 through its most recent update in 2015, has never required employers to provide workers' compensation to farm and ranch laborers. Three farm and ranch laborer workers appealed denial of their workers' compensation injury claims on grounds state statute is illegal under the state's equal protection clause. The statute specifies that in order to be legal, any discriminatory classifications in economic or social legislation have to be founded on some real difference of situation or condition that reasonably justifies a different rule for the class that suffers the discrimination. Continue reading →


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I don't mind being asked to be social and active and will gladly accept if it isn't fun, but my main idea of fun is sitting quietly in a comfortable spot and working on my computer (as in doing ****, not just dicking around online), and while I don't expect people to understand things I prefer to keep to myself, when someone tells me that they feel sorry for me and volunteer to "help" me when they see me alone I want to throttle their ******* neck.


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He said he is ready to get his belt back @metropcs #closerthanever Watch the latest UFC ON FOX content: http://foxs.pt/ZEONsH Connect with UFC ON FOX Online: Visit the UFC ON FOX WEBSITE: http watch video >>
Cat Zingano confident in UFC 200 return, aiming for title shot with win watch video >>
He is back! Megan Olivi is joined by former heavyweight champ Brock Lesnar to discuss his highly anticipated return to the Octagon. Plus, hear Lesnar talk about how he's gotten to where he is in life watch video >>
Eddie Alvarez loves being the underdog going into a big fight. He's confident in his skill set and believes he will become victorious with the belt. Don't miss Eddie Alvarez vs Rafael Dos Anjos July watch video >>
Jessica Andrade talks about he knockout win over Jessica Penne at UFC 199, fighting in a new weight class, the new weigh-in procedure, and much more. Subscribe: http://goo.gl/dYpsgH Check out our watch video >>
Dustin Poirier confident, content at 155 pounds, ready to shine at UFC 199 watch video >>
BJJ Legend Rigan Machado confident Ashton Kutcher would submit Conor McGregor, Conor McGregor enjoy a beautiful day at the beach with his family. ········································ watch video >>
Chad Laprise admits suffering his first professional loss was painful, but he believes his lessons have been learned. The time off proved valuable and he's agreed to face to face veteran Ross Pearson watch video >>
MMA H.E.A.T.'s Wade Eck was backstage at UFC 196 where he heard from UFC Heavyweight Ben Rothwell. Rothwell explained how he thinks there's a lot of cowards in the UFC and he's happy to be fighting watch video >>
Subscribe Free to our YouTube Channel https://t.co/YYKn7lGXFJ @JonathanShrager talks with highly-touted British Welterweight Tom Breese regarding his copious plaudits, training under Firas Zahabi an watch video >>
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Timothy Bradley "Pacquiao was stronger in 2012, Im so confident, I feel refreshed" In this Manny Pacquiao vs. Timothy Bradley 3 video, Tim Bradley speaks on his upcoming Pacquiao vs. Bradley 3 fight watch video >>
They fight January 2nd at UFC 195 in Las Vegas. watch video >>
Gabi Garcia looks really confident talking about fighting Ronda Rousey. She says that she would submit Ronda Rousey and that there is no way that Rousey would make her tapout! watch video >>
Nicholas Walters is confident that Vasyl Lomachenko isn't interested in fighting him. watch video >>


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Who can express her wit, and enjoys and can appreciate food.
Someone who can laugh and make me laugh.
A friend.
Someone who enjoys getting off a plane
or curled up on a couch.
Someone who does not equate anger with passion.
Or mistakes possessiveness for affection.
Or believes that arguing is a form of discourse and communication.
All else is in that realm of undefinable; magic, destiny, timing, divine intervention or just a blind date and luck.
and doing the windows
Love in The Time of Cholera
Authors- Knut Hamsun, Romain Rolland, Thomas Mann, Dostoevsky ,Joseph Campbell, Isabelle Allende
Music; Van Morrison. Vivaldi's 4 Seaons
Cafe del Mar, Coco Mbasi, Geoffrey Yeorema, Arvo Part,
Madredeus, Klaus Schulze........
Movies; Wings of Desire, Steamboat Bill, Kasper Hauser, Great Dictator, Whale Rider, Wages of Fear, Man on Fire, Mean Streets, Touch of Evil, Freaks, Beauty & The Beast,
Red Shoes, It, Spies, M, The Claim, The Proposition, The Phantom Of The Opera............
Arbuckle, Keaton, Herzog, Fritz Lang, Lon Cheney.......
TV: John From Cincinnati, Carnival,Epitafios, Profugos
Food; Tarragon, Galangal, Apricots, Thai, Vietnamese, Indonesian, Spanish, Mexican
Places: Barcelona, Stockholm, Jakarta, Boracay, Capetown


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jul 18, 2006
|Filing date
|Sep 27, 2002
|Priority date
|Mar 3, 1995
|Fee status
|Also published as
|Publication number
|Julie Irene Jones, Anthony Richard Baker, Neil Graham Halls, Peter Watmough, Peter Marriott
|Original Assignee
|Connetics Australia Pty Ltd
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (29), Non-Patent Citations (4), Referenced by (47), Classifications (17), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation of U.S. patent application Ser. No. 09/624,473 (now abandoned), filed Jul. 24, 2000 as a divisional of U.S. patent application Ser. No. 08/913,144 (now U.S. Pat. No. 6,126,920), filed Jan. 12, 1998 as a �371 United States National Phase filing of PCT/GB96/00490 (expired), filed Mar. 1, 1996 claiming priority from GB 9504265.1, filed Mar. 3, 1995. The entire contents of each of the earlier applications is incorporated herein by reference.
The present invention relates to an improved pharmaceutical composition for the topical administration of corticosteroid-active substances to the skin of a subject.
Corticosteroids, particularly in the form of ester compounds, are used, inter alia, in the treatment of skin diseases in humans, such as, for example, eczema, infantile eczema, atopic dermatitis, dermatitis herpetiformis, contact dermatitis, seborrheic dermatitis, neurodermatitis, psoriasis and intertrigo. Formulations containing such active substances have conventionally been applied to the skin site in the form of alcoholic solution, lotions or creams. However, there is a high degree of ineffectiveness with such formulations. Lotions and creams are generally too viscous o allow efficient penetration of the active ingredient to the epidermis, and solution have a tendency to evaporate before penetrating the epidermis. In addition, convention cream bases are irritating to the ski, particularly over the often long exposure that is required, and the fluidity of lotions often makes the physical application difficult to control. Moreover, it is necessary to rub such formulations into the target site to improve the penetration of the active substance into the epidermis, an action which itself produces irritation.
There has therefore been a very real need in the treatment of skin disorders requiring treatment with corticosteroids for improved formulations which target the most effective corticosteroid to the skin site with improved delivery of the active substance, with decreased inconvenience and irritation, and increased ease of use for the patient.
The present invention provides an improved composition which addresses these needs.
In one embodiment, the present invention provides a foamable pharmaceutical composition comprising a corticosteroid active substance, a quick-break foaming agent, a propellant and a buffering agent.
Such a composition is applied to the skin site (after foaming) as a foam which is a thermophobic (heat sensitive) quick-break foam. On application to the skin, the composition is initially in the form of a mousse-like foam. The quick-break foam slowly breaks down at the skin temperature to a liquid to allow the alcohol and active substance to saturate the treatment site. Such a system provides enhanced penetration of the alcohol and active substance through the epidermis. Because the composition is supplied as a mousse, the semi-rigid behavior of the composite makes it easier to handle and physically control. The foamed composition, when applied, provides a thick ball of foam which disintegrates easily when spread, allowing proper coverage of the skin site to be treated without premature evaporation of the solvent. It has been found important to include a buffering agent in the composition to stabilize the active isomer of the corticosteroid active substance in the complex foamable composition, otherwise the complex interactions within the foamable composition may result in the instability of the more active isomer.
Use of a quick-break foaming agent is required in the present invention. Such agents are known. Suitable quick-break foaming agents in the present invention are those described in Australian Patent Number 463216 and Published International Patent Application WO 85/01876. It is generally preferred that the quick-breaking foaming agent comprises an aliphatic alcohol, water, a fatty alcohol and a surface active agent. Particularly preferred is a quick-break foaming agent having the following composition:
In the quick-break foaming agent, the fatty alcohol may be chosen from, for example, cetyl, stearyl, lauryl, myristyl and palmityl alcohols and mixtures of two or more thereof. Mixtures of cetyl alcohol and a stearyl alcohol such as octadecan-1-o1 have been found to be particularly preferred; the ratio between these two components may be adjusted to maintain foam viscosity throughout the broadest possible temperature range. In this situation, the stearyl alcohol maintains the viscosity at temperatures above 20� C. whilst cetyl alcohol maintains the viscosity below 20� C.
The aliphatic alcohol may preferably be chosen from methyl, ethyl, isopropyl and butyl alcohols, and mixtures of two or more thereof. Ethanol has been found to be particularly preferred.
Surface active agents utilized in the quick-break foaming agent may preferably be chosen from ethoxylated sorbitan stearate, palmitate, oleate, nonyl phenol ethoxylates and fatty alcohol ethoxylates, and mixtures of two or more thereof. Thus, for example, Polysorbate 60 (a mixture of partial stearic esters of sorbitol and its anhydrides copolymerized with approximately 20 moles of ethylene oxide for each mole of sorbitol and its anhydrides) has been found to be particularly preferred. The surface active agent enhances the fatty alcohol solubility in the system and enhances foam formation.
The propellant used may be chosen from conventional aerosol propellants. Thus, one may select the propellant from propane, butane, dichloro difluoro methane, dichloro tetrafluoro ethane, octafluoro cyclobutane, and mixture s of two or more thereof. It is necessary to select a propellant most compatible with the entire system. It is particularly preferred that the propellant be present in amounts preferably of 3–30% w/w, more preferably, 3–10% w/w, and most preferably, 3–5% w/w. The maximum level of propellant will be determined as the amount miscible with the utilized water/aliphatic alcohol ratio. In addition to acting as a propellant, the propellant will also act as a solvent for the fatty acids and active substances in the aqueous/alcoholic system.
It is possible that other additives may be used. Thus, it is preferred to add a humectant to reduce the drying effects of the aqueous aliphatic alcohol. Such a humectant may preferably be present in an amount of 0.1–10% w/w and more preferably 0.5–3.0% w/w. To is particularly preferred that the humectant be propylene glycol, but other humectants such as glycerine, panthenol and sorbitol may also be use.
The composition of the present invention may be used to deliver corticosteroid compounds which have utility in the topical treatment of skin disorders. Thus, for example, the composition of the present invention may be used to deliver the following topically-effective corticosteroid:
alclometasone dipropionate
fluclorolone acetonide
fluocinolone acetonide
beclomethasone dipropionate
betamethasone benzoate
fluocoritin butyl
betamethasone dipropionate
fluocortolone preparations
betamethasone valerate
fluprednidene acetate
clobetasol propionate
clobetasol butyrate
hydrocortisone butyrate
methylprednisolone acetate
diflucortolone valerate
mometasone furoate
flumethasone pivalate
triamcinolone acetonide
and pharmacologically effective mixtures thereof
Compositions according to the invention are especially advantageous for the topical administration to the skin of human subjects of betamethasone and its derivatives, such as betamethasone benzoate, betamethasone dipropionate and betamethasone valerate. It is particularly preferred to use the valerate ester, especially in the treatment of psoriasis.
The corticosteroid active substance is preferably present in an amount o 0.01–1.0% w/w and more preferably, 0.05–0.2% w/w.
In view of the complexity of the composition, it has been found that unexpectedly, in order to ensure stability of the active isomer of the corticosteroid in the composition, and thus to ensure delivery of the most active isomer to the epidermis, it is necessary to buffer the composition by including a suitable buffering agent. Suitable buffering agents are acetic acid/sodium acetate, citric acid/sodium citrate and phosphoric acid/sodium phosphate, and it is desirable generally to buffer the composition to pH 3.0 to 6.0 and preferably, to pH 4.0–5.0. To this end, the buffering agent may preferably be present in an amount of 0.01–1.0% w/w and more preferably 0.05%–0.2% w/w. It is particularly preferred to use a citrate buffer system, and more preferably, anhydrous citric acid/potassium citrate, to buffer the composition to pH 4.5, when betamethasone valerate is used as the active substance; in this case, citrate buffering stabilizes the more active 17-valerate ester over the less active 21-valerate ester in the complex composition and ensures that the most effective form of the active substance is efficiently delivered to the epidermis.
Preparation of the composition may be affected by conventional means, so as to produce a homogeneous solution of fatty alcohol(s) or wax(es), in the alcohol/water base. The relative proportions of the fatty alcohol(s), water/aliphatic alcohol and propellant are conveniently controlled according to conventional means so as o provide a homogeneous clear solution and so as to allow the formation of a suitable quick-break foam. Generally speaking, the fatty alcohol(s), surface active agent, aliphatic alcohol and humectant (when present) are preferably mixed together with the corticosteroid active substance to produce and "alcohol phase". An "aqueous phase" is preferably produced by mixing the buffering agent and water. These phases are then mixed, preferably in the final container, in the required amounts. The propellant is then added under pressure to produce he composition according to the present invention.
In the case of betamethasone valerate, for example, it is particularly preferred to use a composition comprising cetyl alcohol and octadecan-1-o1 as fatty alcohols, together with Polysorbate 60 surface active agent, with purified water and ethanol as the aliphatic alcohol. The system is preferably buffered with anhydrous citric acid potassium citrate and the propellant is preferably butane/propane. It is generally preferred to choose the proportion of the components to achieve a fixed pressure in the container of around 50–70 psi.
The composition of the present invention may be contained in and dispensed from, a container capable of withstanding the pressure of the propellant gas and having an appropriate valve/nozzle for dispensing the composition as a foam under pressure. If the container is made of metal material likely to suffer corrosion under the action of the composition, the composition may include a corrosion inhibitor as an additive. Thus, the present of a corrosion inhibitor may be necessary if the container is made of tin plate. Suitable corrosion inhibitors include organic acid salts, preferably chosen from sorbic acid, benzoic acid, sodium benzoate and potassium sorbate. If used, the corrosion inhibitor maybe present in amounts of 0.1–15% w/w and more preferably, 0.1–3.0% w/w. In the present invention, aluminum cans are preferred as containers, particularly when utilizing the above-mentioned composition for betamethasone valerate as the corticosteroid active substance; in this case, there is no corrosion problem and there is no need of the inclusion of a corrosion inhibiting agent.
In use, the composition is sprayed, producing a semi-solid (i.e. a foam or mousse) that is suitable for the topical application to the scalp. On application, heat from the skin causes the mousse to break down into liquid form, thus releasing the aliphatic alcohol and corticosteroid active substance which penetrate the skin site, leaving a low amount of residue, many times lower than those obtained when delivering active ingredient from a cream base. This route of administration facilitates the ease of specific local applications, and the composition according to the present invention provides a convenient, controllable and efficient vehicle for delivering active substance to the skin. This gives greater physical control compared to conventional topical corticosteroid formulations, minimizes rubbing of the target site and allows the alcoholic vehicle to penetrate the skin to deliver the active ingredient where it will have the greatest effect.
The composition of the present invention may be used in treating skin diseases that are conventionally treated with corticosteroid active substances. Thus, the composition may be use in the treatment of, inter alia, eczema, infantile eczema, atopic dermatitis, dermatitis herpetiformis, contact dermatitis, seborrheic dermatitis, neurodermatitis, psoriasis and intertrigo. The composition is especially useful in the treatment of scalp psoriasis in human subjects.
The principals of the present invention are illustrated below by means of the following non-limiting example.
A betamethasone valerate formulation having the following composition was prepared:
Ingredient % w/w betamethasone valerate .12 cetyl alcohol BP 1.10 octadecan-1-ol BP 0.50 Polysorbate 60 BP 0.4. ethanol 57.79 purified water 33.69 propylene glycol BP 2.00 citric acid anhydrous BP 0.073 potassium citrate 0.027 butane/propane 4.30 100.000
Alcoholic Phase
Cetyl alcohol (HYFATOL 1698, Efkay Chemicals Limited, London, England), octadecan-1-o1 (HYFATOL 1898, Efkay Chemicals Limited, London, England), Polysorbate 60 (CRILLET 3, Croda Chemicals, North Humberside, England) and ethanol in the appropriate proportions were mixed and heated to about 45� C., with continuous stirring until the mix became clear. Betamethasone valerate BP (Roussel Uclaf, Virtolaye, France) was slowly transferred into the mix, again with continuous stirring until the mix became clear.
Aqueous Phase
Purified water was separately heated to 45� C. and anhydrous citric acid BP and potassium citrate BP transferred to the water, with continuous stirring until dissolved.
The alcoholic and aqueous phases were each filtered through 75μ screens and the required weights filled into a can (epoxy lined aluminum) at room temperature. After attaching a valve, the butane/propane propellant (Propellant P&)) was added to the mix in the can to the required weight, and an actuator added to the valve.
The composition, on being sprayed from the can onto the skin, produces a thermophobic foam which breaks down under heating from the skin to release the active ingredient to the epidermis. The presence of the citrate buffer stabilizes the 17-valerate configuration of the betamethasone valerate over the less active 21-valerate configuration, thus producing a composition which efficaciously delivers the active ingredient to the epidermis and which is particularly suitable for the treatment of psoriasis, especially scalp psoriasis.
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|May 1, 2000
|Nov 9, 2000
|Soltec Research Pty. Ltd.
|Non-aqueous liquid shampoo composition
|Albert Zorko Abram and Roderick Peter John Tomlinson, Mousses, Chapter 19, pp. 221-232, Soltec Research Pty Ltd., Rowville, Victoria, Australia, Jun. 2001.
|Timmens, P. and Gray, E., "The degradation of triamcinolone acetonide in aqueous solution: influence of the cyclic ketal function," J. Pharm. Pharmacol., 35:175-177 (1983).
|Woodford, R. and Barry, B. W., "Bioavailability and Activity of Topical Corticosteroids from a Novel Drug Delivery System, the Aerosol Quick-Break Foam," J. Pharm. Sci., 66:99-103 (1977).
|Yip and Po "The stability of betamethasone-17-valerate in semi-solid bases" J. Pharm. Pharmacol. 31, 400-402 (1979).
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|Nov 13, 2000
|Jan 8, 2008
|Galderma S.A.
|Foaming composition for washing and treating hair and/or scalp based on an active principle
|Jun 16, 2006
|Apr 20, 2010
|Galderma S.A.
|Foaming compositions for hair care
|Nov 13, 2007
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|Galderma S.A.
|Foaming composition for washing and treating hair and/or scalp based on an active principle
|Nov 29, 2011
|Galderma S.A.
|Foaming compositions for hair care
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|Foamix Ltd.
|Oleaginous pharmaceutical and cosmetic foam
|Jul 8, 2009
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|Foamix Ltd
|Foamable iodine compositions
|Mar 13, 2007
|Feb 21, 2012
|Foamix Ltd.
|Foamable compositions, kits and methods for hyperhidrosis
|Jul 6, 2006
|Feb 21, 2012
|Foamix Ltd.
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|Jun 7, 2010
|Jan 1, 2013
|Foamix Ltd.
|Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
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|Foamix Ltd.
|Foamable vehicle and pharmaceutical compositions thereof
|May 7, 2013
|Foamix Ltd.
|Penetrating pharmaceutical foam
|Jan 14, 2008
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|Foamix Ltd.
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|Feb 20, 2012
|Jul 16, 2013
|Foamix Ltd.
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|Jul 16, 2013
|Foamix Ltd.
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|Feb 12, 2010
|Aug 20, 2013
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|Oct 6, 2009
|Aug 27, 2013
|Foamix Ltd.
|Oil-based foamable carriers and formulations
|Sep 14, 2010
|Aug 27, 2013
|Foamix Ltd.
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|May 4, 2011
|Dec 31, 2013
|Foamix Ltd.
|Compositions, gels and foams with rheology modulators and uses thereof
|Aug 7, 2008
|Jan 28, 2014
|Foamix Ltd.
|Wax foamable vehicle and pharmaceutical compositions thereof
|Mar 11, 2013
|Apr 22, 2014
|Foamix Ltd.
|Oleaginous pharmaceutical and cosmetic foam
|Jul 14, 2010
|Apr 29, 2014
|Foamix Ltd.
|Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
|Mar 6, 2013
|May 13, 2014
|Foamix Ltd.
|Foamable carriers
|Mar 4, 2013
|Jun 3, 2014
|Foamix Ltd.
|Penetrating pharmaceutical foam
|Nov 1, 2013
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|Micron Technology, Inc.
|Techniques for reducing disturbance in a semiconductor memory device
|May 12, 2010
|Aug 5, 2014
|Foamix Ltd.
|Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
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|Aug 5, 2014
|Foamix Ltd.
|Compositions with modulating agents
|Apr 28, 2005
|Sep 23, 2014
|Foamix Ltd.
|Body cavity foams
|Jul 9, 2014
|Oct 21, 2014
|Foamix Pharmaceuticals Ltd.
|Topical tetracycline compositions
|Oct 1, 2010
|Oct 28, 2014
|Foamix Ltd.
|Topical tetracycline compositions
|Jun 7, 2010
|Dec 2, 2014
|Foamix Pharmaceuticals Ltd.
|Oil and liquid silicone foamable carriers and formulations
|Feb 20, 2012
|Dec 2, 2014
|Foamix Pharmaceuticals Ltd.
|Foamable composition and uses thereof
|Oct 1, 2010
|Feb 3, 2015
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|Mar 31, 2015
|Foamix Pharmaceuticals Ltd.
|Topical tetracycline compositions
|Apr 7, 2014
|Jun 9, 2015
|Foamix Pharmaceuticals Ltd.
|Oleaginous pharmaceutical and cosmetic foam
|Jan 27, 2012
|Jul 7, 2015
|Foamix Pharmaceuticals Ltd.
|Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
|Oct 3, 2013
|Aug 11, 2015
|Foamix Pharmaceuticals Ltd.
|Compositions with modulating agents
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|Foamix Pharmaceuticals Ltd.
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|Jan 27, 2012
|Oct 27, 2015
|Foamix Pharmaceuticals Ltd.
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|Foamix Pharmaceuticals Ltd.
|Antibiotic kit and composition and uses thereof
|Jul 5, 2007
|Feb 23, 2016
|Foamix Pharmaceuticals Ltd.
|Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
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|Foamix Pharmaceuticals Ltd.
|Sensation modifying topical composition foam
|Aug 31, 2010
|Jun 14, 2016
|Dr. Reddy's Laboratories Ltd.
|Topical formulations comprising a steroid
|Jun 16, 2006
|Oct 19, 2006
|Isabelle Preuilh
|Method for treating ailments of the scalp
|Nov 13, 2007
|Mar 20, 2008
|Galderma S.A.
|Foaming composition for washing and treating hair and/or scalp based on an active principle
|Sep 22, 2014
|Apr 2, 2015
|Ranbaxy Laboratories Limited
|Topical spray composition of halobetasol
|Sep 24, 2014
|Apr 2, 2015
|Ranbaxy Laboratories Limited
|Propellant-free topical spray composition of halobetasol
|Mar 11, 2015
|Sep 17, 2015
|Promius Pharma, LLC
|Topical corticosteroid compositions
|U.S. Classification
|424/495, 424/43, 424/45
|International Classification
|Cooperative Classification
|European Classification
|Oct 25, 2004
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Hotfrog UK provides information regarding Jinder Catering in West Bromwich WEST MIDLANDS. Jinder Catering is located at West Bromwich WEST MIDLANDS B70 9QP and provides bar services. Contact them on 0121 580 0081 or by visiting them on their website http://jindercatering.com.
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No Way Rosé - Summer's Cool Wines - Friday, August 26, 2016
You'll say "yes way" to summer's hippest wine style!
Time: 7:00-9:30pm
Location: Steinfels Weinhandel, Pfingstweidstrasse 6, 8005-Zürich
Price: 85.- chf per person
(includes 6-7 wines & with 5-6 food courses)
Rosé wines are surging in popularity while remaining a wine world paradox--adored in some areas, shunned in others. The misunderstanding? Well, there are great rosés but unfortunately lots of plonk too; to make matters worse, color and price are no indicators of quality.
What's a hot, thirsty, confused wine drinker to do? Join this Wine, Food, Wine! event and taste the whole spectrum of summer's coolest wines, from delicate blushing masterpieces to deeply extracted "construction workers'" rosés. We even include two infamous rosés produced by Hollywood's Brangelina pair. Part of the puzzle is how the wines' personalities develop with certain foods... the dishes we're serving that evening! Includes 6-7 wines, 4-5 specially-prepared food pairings and an entertaining group for chatting about your favorites.
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Infosecurity Europe is the founding brand of Infosecurity Group – a business unit of Reed Exhibitions UK Ltd. It is Europe's number one information security event, featuring the largest and most comprehensive education programme, and over 360 exhibitors showcasing the most diverse range of products and services to 18,000 infosecurity professionals. The 22nd edition of the event will take place at Olympia in London, 6-8 June 2017.
6th – 8th June 2017Olympia, London - United Kingdom Opening times:Tues 6th June 09.30 - 17.30Wed 7th June 09.30 - 17.30Thur 8th June 09.30 - 16.00
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The Information Security Europe visitor audience is made up of a diverse range of IT security professional coming from key sectors such as:
With 13,481 unique visitors from 77 countries passing its doors, Infosecurity Europe 2016 was a great success. While our team works towards the delivery of a even greater 22nd edition of Infosecurity Europe in 2017, find out about the latest facts and figures.
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Family Stations Inc
Rating: 2.33 stars 3 3 reviews 1,733
290 Hegenberger Rd Oakland CA 94621 USA
Radio and television broadcasting of Christian teachings
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Reviews for Family Stations Inc
3 people found this review helpful
Family Radio seems to be out of control. They have sold WFSI Annapolis, and sold WKDN Camden. They are in the red and no pastors or churches support them anymore. Stay away, it seems they are no longer a Christian ministry.
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Family Radio should be avoided. They collect monies from the public with the stated purpose of their assets being "dedicated to a religious use," per their Articles of Incorporation. But then they sell the asset to a non-Christian, secular organization. A number of the Regional managers quit the corporation in 2011. The Board of Directors cannot be trusted. They simply rubber stamp every wish of Harold Camping. But now the latest twist is that Media Venture Partners is a essentially acting as an under the table board member and determining company policy. Family Radio cannot be trusted and your money is wasted.
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I have been a Family Radio listener since 1987. I have known no ministry to have such an insatiable desire to serve God in the most faithful way possible than Family Radio. Despite the failed prediction of the rapture, the end of the world, and the ensuing fallout, Family Radio continues to serve God with the same fervor it has since February 4, 1959. Family Radio has been operating as a non-profit, non-commercial conservative Christian ministry with the singular goal of obeying God's command to go into all the world and preach the Gospel to every creature (Mark 16:15). Never hesitate to give to the ministry of Family Radio, and give liberally. Your gift will go toward getting the Gospel to the many, many people who still have not heard the Lord's precious word of grace. And to God be the Glory, forever and ever. --MEO
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Wose Community Church Of Oakland
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Chabad Jewish Center of Oakland
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Rabbi and Rebbezin Labkowski are a dynamic and highly educated young couple who moved to Oakland with no family, no contacts and... more »
East Bay Meditation Center
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Word Of Faith Christian Ministries International
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Word of Faith Christian Ministries helps a lot of people. They have a caring attitude about humanity. There drug and alcohol... more »
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text:
Parker leads Canyon past Brea Olinda
Canyon boys basketball coach Nate Harrison made his way to the newest Comanche, Jim Kunau, and told him how excited he was to have the decorated football coach in the athletic program.
"I love how hard you guys play," a gracious Kunau replied.
The Comanches grinded out a 65-60 victory against Brea Olinda in a Century League game Thursday night, extending the celebration from a halftime introduction for the recently hired Kunau.
"I'm glad I didn't mess up that exciting night," Harrison said.
Canyon had its defense and junior guard Devonte Parker to thank for that. Parker scored a career-high 23 points, his five 3-pointers pulling the Comanches out of an offensive funk.
Canyon (9-3, 2-0) has won four in a row, all without point guard Anthony Ballestero, who broke his arm last week and is expected to miss 2-4 weeks.
The situation looked bleak in the first half against the Wildcats (6-3, 0-1), who built a 10-point lead while baiting Comanches leading scorer JoJo Ballestero into foul trouble.
Parker assumed the senior sharpshooter's role in the offense and nailed a pair of 3-pointers as Canyon cut the deficit to two by halftime. In the third quarter, Parker scored 13 of his team's 25 points while Canyon went ahead by six. JoJo Ballestero finished with 13 points.
"We've struggled the last five games without Anthony Ballestero," Harrison said. "He's so important to what we do. We just kind of fumbled around. ... Devonte Parker came up humongous."
The Comanches' defense took care of the rest. Brea Olinda guard Michael Turner had 23 points and center Vilius Vysniauskas had 15, but the two were each held to a single field goal in the final quarter.
"We're going to try to beat you every possession," Harrison said. "When we needed stops, we got stops. We played really hard defensively. I though that was the difference, really."
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Girls on the Run holds successful event
|Photo courtesy of the Shaw Jewish Community Center of Akron
According to event officials, the event had more than 1,200 participants, including GOTR program participants, coaches, friends and family.
The GOTR 5K is a noncompetitive event in which everyone is a winner, according to event officials. The GOTR program combines training for a 5K running event with healthy living education that instills self-esteem through health education, life skills development, mentoring relationships and physical training, according to event officials.
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text: Learning Under the Bridge Every morning, the underside of a railway bridge in India's capital becomes a classroom for more than 50 local children. May 6, 2013 11:18 a.m. ET fullscreen A group of children walked one April morning toward their school, set up in a makeshift space under a railway bridge in New Delhi. Altaf Qadri/Associated Press … From Monday through Saturday, Laxmi Chandra, right, and Rajesh Kumar, second from right, teach two hours of lessons to more than 50 children gathered in this classroom under elevated rail tracks. Altaf Qadri/Associated Press … Blackboards are black rectangles painted on a chipped concrete wall; children copy the lessons into their notebooks. The students, ages 4 to 14, study everything from basic reading and writing to the Pythagorean theorem. Altaf Qadri/Associated Press … Mr. Kumar, a shop owner with no formal training, started the informal school in 2008, when local parents complained the public school was too far away and that their children would have to cross a dangerous highway to get there. Altaf Qadri/Associated Press … The school stands as proof of the hunger for learning among those either left out of the system or disappointed by it. Students help set up the space each day; this boy carried rolled-up flooring for storage at the end of a school day last month. Altaf Qadri/Associated Press … 'To change the future of these children, education is the only weapon,' says Mr. Kumar, shown here setting up a makeshift toilet at the free school, with the help of students. Altaf Qadri/Associated Press … An Indian donor, seeing an Associated Press photo essay on the school, gave the children socks, shoes and backpacks. Before the start of class one day in April, this boy received new socks and shoes. Altaf Qadri/Associated Press … Mr. Kumar works to enroll the students in government schools and said he has managed to enroll 130 children in the state education system. 'They can get a degree there. I can't give them that,' he said. Altaf Qadri/Associated Press … But many children who attend government schools come back to study with Mr. Kumar, as well. A girl takes notes from a blackboard painted on a wall. Altaf Qadri/Associated Press … A girl helps her little brother put on a pair of donated shoes. Altaf Qadri/Associated Press … A girl sweeps the floor before the start of classes. Altaf Qadri/Associated Press … Children walk home at the end of classes at Mr. Kumar's school. About 3 million children in India remain out of school, the government says. Mr. Kumar fears his project is precarious. He needs more volunteer teachers, and his unregistered school is squatting on railroad property. Altaf Qadri/Associated Press … Replay Learning Under the Bridge More Slideshows Photos of the Day: July 24 George Wein's Newport Jazz Years of SHOW CAPTION HIDE CAPTION fullscreen Show More Archives


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Explain the concept of continuous monitoring after the CSP FedRAMP authorization is secured?
Roat: To receive reauthorization of a FedRAMP provisional authorization from year to year, CSPs must monitor their security controls through monthly, quarterly and annual assessments to demonstrate that the security posture of their service offering is continuously acceptable.
Ongoing assessment of security controls results in greater transparency into the security posture of the CSP system and enables timely risk-management decisions.
Security-related information collected through continuous monitoring is used to make recurring updates to the security assessment package. Ongoing review of security controls enables the security authorization package to remain current, which allows agencies to make informed risk management decisions as they use cloud services.
How does launching of new services/architecture affect existing CSP FedRAMP authorization?
Roat: Changes to the CSP's offerings that are within the scope of their system and their current FedRAMP P-ATO are handled through the continuous monitoring change control process. If the new offering or architectural change represents a significant change in the system, the CSP must determine the security impact of the change, notify their ISSO before implementing the change and complete a Significant Change Security Impact Analysis form.
The planned change is reviewed by the ISSO and then forwarded to the JAB for approval. All plans for significant changes should include rationale for making the change and plans for testing prior to implementation in production.
If any anticipated change adds residual risk, changes a leveraging agency's security posture or creates other risk exposure that the JAB finds unacceptable, the provisional authorization could be revoked. The P-ATO could also be revoked if the change is made without prior approval.
A CSP that launches a new service or a new architecture that is not in the scope of the FedRAMP P-ATO may be required to submit this new service for a separate FedRAMP JAB review.
Explain the role and responsibilities of the 3PAOs.
Roat: Third-party assessment organizations (3PAOs) perform initial and periodic assessment of the cloud service provider's systems according to FedRAMP requirements. They also provide evidence of compliance and play an ongoing role in ensuring CSPs continue to meet requirements. Once engaged with a CSP, 3PAOs develop security assessment plans, perform testing of cloud security controls and develop security assessment reports. FedRAMP provisional authorizations must include an assessment by an accredited 3PAO to ensure a consistent assessment process.
In the security assessment process, FedRAMP requires that CSP services and systems be assessed by an accredited 3PAO. Accredited 3PAOs are required to meet the ISO/IEC 17020:1998 standards for independence and managerial competence and meet FedRAMP requirements for technical FISMA competence through demonstrated expertise in assessing cloud-based solutions.
Are there any publicly available pricing, rating or backlog details available for the existing 3PAOs?
Roat: The pricing for the 3PAO's services is negotiated between the cloud service provider and the 3PAO and is not available through FedRAMP.
3PAOs are not rated; however, any complaints about performance are tracked through the accreditation process, and a lack of performance could result in the loss of the 3PAO's accreditation.
Explain the upcoming privatization and expansion of 3PAOs certification.
Roat: As outlined in the FedRAMP concept of operations and the 3PAO program description, the transition to a privatized accreditation body for 3PAO's was planned from the start of FedRAMP.
A2LA was selected through an open process for selecting accreditation bodies with the experience and knowledge to accredit 3PAOs that perform assessment of cloud systems.
A2LA is a signatory of the International Laboratory Accreditation Cooperation (ILAC) Mutual Recognition Arrangement (MRA). The MRA acts as an internationally recognized "stamp of approval" to demonstrate compliance against agreed standards and requirements.
Having A2LA as the accreditation body will allow for more in-depth analysis of 3PAO applicant's conformance to inspection and information security standards, making the process more rigorous. Having a privatized body also provides a means of costs savings, as the government does not have to provide the resources to perform the accreditation.
The FedRAMP PMO retains oversight and governance for the accreditation process including final approval of 3PAOs.
The cybersecurity profession struggles to retain women (figures range from 10 to 20 percent). It's particularly worrisome for an industry with a rapidly growing number of vacant positions.
So why does the shortage of women continue to be worse in security than in other IT sectors? How can men in infosec be better allies for women; and how can women be better allies for one another? What is the industry doing to fix the problem -- what's working, and what isn't?
Is this really a problem at all? Are the low numbers simply an indication that women do not want to be in cybersecurity, and is it possible that more women will never want to be in cybersecurity? How many women would we need to see in the industry to declare success?
Join Dark Reading senior editor Sara Peters and guests Angela Knox of Cloudmark, Barrett Sellers of Arbor Networks, Regina Wallace-Jones of Facebook, Steve Christey Coley of MITRE, and Chris Roosenraad of M3AAWG on Wednesday, July 13 at 1 p.m. Eastern Time to discuss all this and more.