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When it comes to creative high-tech, Montréal ranks among the top cities in the world, often being called the capital of the digital arts in North America. New digital arts projects, video game production, the visual effects industry and virtual reality innovations all thrive here and are among the many reasons why Montréal Digital Spring has garnered international attention. The annual citywide event promises to free your mind and your body with interactive exhibitions and audio-visual performances, architectural installations and contemporary creations that cross artistic and scientific currents. Rules are meant to be broken during Digital Spring, so follow our Survival Guide to see the city of the future, now. THE EVENT The 3rd edition of Montréal Digital Spring digital arts and culture initiative, at various locations throughout Montréal from March 21 to June 21, 2016. WHAT YOU'RE GETTING YOURSELF INTO Whether you're a forerunner in cutting-edge technology or your kids just figured out your smart phone for you, Montréal Digital Spring can take you however deep into the high-tech arts rabbit hole you desire. Also known as Printemps numérique, Digital Spring partners with local arts and culture organizations – meaning the whole city gets in on the act, from… / Read More →
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Things to do in Montréal: February 12 to 18
Montréal pairs Valentine's sparkle with glittering winter entertainment this week – the city's top restaurants and hotels ready for romance, and the MONTRÉAL EN LUMIÈRE winter festival kicks off, along with inspiring international ballet, contemporary dance, art, theatre, film and live music. City lights Winter, spring, summer or fall, we're counting the ways Montréal warms our hearts – and this week's kickoff of massive winter festival MONTRÉAL EN LUMIÈRE has us all fired up. Opening Thursday, February 18, the family-friendly festival's free outdoor site entertains with multimedia shows, ice slides, a Ferris wheel, fabulous food and more, while indoors see dozens of musicians and performers, including Swiss Maestro Charles Dutoit and Argentine pianist Martha Argerich with the Montréal Symphony Orchestra at Place des Arts February 18 and 20. Day or night, skate next to the Saint-Lawrence River at the Bonsecours Basin ice skating rink in the Old Port and at the Village MAMMOUTH at the Olympic Park Esplanade. Also near the Olympic Park, the wonders of the natural world await at the Space For Life, home to the Biodôme, Botanical Garden and Planetarium – the Botanical Garden's Butterflies Go Free exhibit opens February 18, this year butterflies share the spotlight… / Read More →
Things to do in Montréal January 8 to 14
The year is already off to a bold start in Montréal with snow-bright outdoor entertainment to play with and dance to, the Happening Gourmand restaurant fest, internationally acclaimed dance, theatre and film, and live music from Tchaikovsky to Mark Farina. Snow days With memories of 2015 fading it's time to make some new ones. Montreal brightens up your winter with all kinds of activities and entertainment in the coming months. Play on the 30 illuminated see-saws of interactive art exhibition Luminothérapie until January 31, with animated digital art projections throughout the Quartier des Spectacles. If you love to dance and love being outdoors, get yourself to Igloofest, Montreal's biggest winter electronic music festival, at Jacques-Cartier Quay in the Old Port, opening January 14 with music by Bonobo, Lunice, Heron Preston and more. Go ice skating and sliding at Village MAMMOUTH at the Olympic Stadium Esplanade, or skate to music at the Old Port's Bonsecours Basin rink, with happy hour every evening. On the ice at the Bell Centre, the Montréal Canadiens take on the Penguins on January 9 and the Blackhawks on January 14. Seek out warmth and art at the Montreal Museum of Fine Arts, the Musée d'art contemporain and Galerie… / Read More →
Things to do in Montréal: January 1 to 7
A new year, a new week – welcome to 2016 and welcome to Montréal! The genuine joys of the holiday season continue into this week at excellent restaurants and bars, outdoor markets, museums and music venues, and out on the streets and ice rinks of the city. New Year's eats We could technically still call this "the holidays," and many of the restaurants in our guide to holiday menus in Montréal do! From six-service table d'hôtes to classic French fare, welcome in the New Year with an excellent meal or two. Celebrate your love of wine and good food at these 10 wine-devoted restaurants. Get your fill of Peking Duck and dumplings on New Year's Day at these Chinese food restaurants open over the holidays. If a burger and fries is your comfort food, get back to basics with these 5 must-try burgers. And since a vacation isn't enough time to try everything Montréal's cuisine scene has to offer, bring these made-in-Montréal treats home and pack a bottle of celebratory Québec-made alcohol, whether it's gin or sparkling cider. Rewarding resolutions If you're prone to making New Year's resolutions, it's easy to follow through on the fun ones in Montréal: skydive… / Read More →
Must-see 2016 Montréal museum exhibitions
Several blockbuster exhibitions will be on display at Montréal museums in 2016. Here are some choice picks: The much-anticipated POMPEII: A Roman City exhibition chronicles the life and death of Pompeii and neighbouring town Herculaneum, which were destroyed by the spectacular eruption of Mount Vesuvius in 79 A.D. By that time, Pompeii had become a wealthy playground for some of Rome's most influential citizens. When the city was buried under several metres of volcanic rubble and lava, the city's treasures were protected from the ravages of time. Some 250 years after Pompeii's rediscovery, this exhibition features nearly 200 archaeological artifacts – statues in bronze and marble, mosaics, frescoes and decorative arts – that offer an extraordinary glimpse into daily life at the height of the Roman Empire. POMPEII: A Roman City runs at the Montréal Museum of Fine Arts from Feb. 6 to Sept. 5. The Montréal Museum of Fine Arts will also present the massive Rethinking Robert Mapplethorpe exhibition about the iconic and controversial American photographer famous for his homoerotic male nudes and celebrity portraits, including Richard Gere, Andy Warhol, Yoko Ono and his great friend Patti Smith. This exhibition features 250 works, mostly Mapplethorpe's highly stylized black-and-white photographs, but also colour… / Read More →
Things to do in Montréal: December 25 to 31
During Christmas week, Montréal slows down, a peaceful quality permeating the air – of course, restaurants and bars still serve up fantastic fare, art and cultural activities abound for kids and adults alike, skating rinks and winter villages bustle, and by New Year's Eve everyone is ready to party like it's 2016. Dazzling food and drink Montréal knows that the pleasure and comfort of excellent meals and marvelous drinks is essential to the holiday season. Our guide to holiday menus in Montréal takes you around the city to discover the best in seasonal eating, from six-service table d'hôtes to classic French fare. Also peruse our guide to Restaurants open on Christmas Day for more first-rate feasting options. Add the unique quality of Québec-made alcohols to your holiday cocktails: try gin, vodka, ice wine, ciders and more made by Canadian distilling experts with a flare for flavour. And wine lovers should get cozy at these 10 wine-devoted restaurants. If you're dining with a big family or friends, look into a private dining room experience. And if your holiday tradition involves Peking Duck and dumplings, let us show you where to eat Chinese food on Christmas and New Year's. On the other hand, sometimes you just need a… / Read More →
Things to do in Montréal: December 18 to 24
In the week leading up to Christmas a lot of us are either rushing around getting things done or winding down at last – whether you need to go gift shopping or just want to relax at a show, there's plenty to do in Montréal right up to Christmas and beyond. Merry days and nights Celebrate the season in season in Montréal style at Merry Montréal throughout Old Montréal where you can warm up at fires, drink free hot chocolate, see Santa at the Christmas market at Place Jacques-Cartier, watch Christmas-themed films and more. Over at downtown's Place des festival, let the kids loose and your inner child play at the glittering Le Grand Marché de Noël de Montréal outdoors on the Esplanade of Place des Arts. Also outdoors at Place des Arts, play on the 30 illuminated see-saws of interactive art exhibition Luminothérapie, on until January 31 along with animated digital art projected onto nearby buildings and throughout the Quartier des Spectacles. And Le Festival Noël dans le parc lights up Parc des Compagnons-de-St-Laurent (Mont-Royal Avenue at Cartier) with activities and music on weekday evenings and in the afternoon and evenings on weekends to December 25. More holiday fun For hours… / Read More →
Things to do in Montréal December 11 to 17
This is the week when it really and truly begins to feel a lot like Christmas – whether snow falls or not, the streets are aglitter with seasonal festivities. Go shopping for gifts, play on interactive public art, see The Nutcracker and more on stage, and hear music from choirs to rock bands. Sparkling streets Follow the glittering lights and happy people to Le Grand Marché de Noël de Montréal, a colourful new outdoor winter market right downtown at the Place des Arts Esplanade, December 12 to January 2, where not only can you find great presents but plenty of activities, entertainment and food and drink for the whole family. Montréal celebrates the season all around the city: Merry Montréal turns Old Montréal into a winter wonderland with fires to warm up by, free hot chocolate, Santa at the Christmas market at Place Jacques-Cartier, Christmas-themed films and more; in the Plateau at the Marché de Noël Prince Arthur along Prince Arthur Street starting at the corner of Boulevard St-Laurent see performances, watch films, shop and sample treats; Le Festival Noël dans le parc lights up Parc des Compagnons-de-St-Laurent (Mont-Royal Avenue at Cartier) and Parc Lahaie (Saint-Laurent Boulevard at Saint-Joseph) with activities and live… / Read More →
Festive fun for kids this holiday season in Montréal
If you're visiting Montréal with your family in December, expect to find entertaining seasonal festivities with all the trimmings: Christmas trees and illuminated interactive art, outdoor games and activities, hot chocolate and good food, and, of course, Santa. Treats and presents Lights glitter, friends and family gather, and kids play at Le Grand Marché de Noël de Montréal, a new outdoor winter market right downtown at the Place des Arts Esplanade, December 12 to January 2. Not only a great place to find last-minute locally-made gifts but a joyful event featuring entertainment, music, karaoke and other playful activities for all ages – and plenty to eat and drink, from beaver tails to maple candy. Not far away from Le Grand Marché, see performances, watch films, shop and sample seasonal treats at the Marché de Noël Prince Arthur. And when it's time for a full sit-down meal, consult our extensive list of kid-friendly restaurants. Winter wonderlands Old Montréal turns into a warmer version of the North Pole during the Merry Montréal celebrations – there's free hot chocolate, Christmas-themed films, cozy fires and even see Santa Claus at the Christmas market at Place Jacques-Cartier. Peer into the window of Ogilvy department store… / Read More →
Your 2015 Halloween guide to ghoulish good times in Montréal
Montréal is a ghost town. No, really. Spectres and spooks, shades and wraiths: whatever your flavour of phantom, Montréal comes alive in the spirit of the dead when it comes to Halloween. Indeed, there's no shortage of Halloween hijinks in Montréal again this year, so let the following be your guide to the many tricks and treats being offered. For the little monsters The 30th edition of The Great Pumpkin Ball, at Montreal's Space for Life (comprised of the Biodôme, Insectarium, Botanical Gardens and Planetarium, which are hosting many Halloween-themed events), is in full celebratory swing at the Botanical Gardens. Esmeralda the witch watches over the 800-plus decorated pumpkins, and invites curious munchkins to check out her giant new hat house and other activities. The Great Pumpkin Ball takes place daily, 9 am to 9 pm, until November 1. The most frightening real-life vampires for many, spiders are also among the most fascinating. Fearsome and amazingly diverse hunters, the Insectarium will be putting the spotlight on these incredible creatures this Halloween season as part of a daily guided activity, until November 1. Partake in pumpkin treats with all the animals of the Biodôme. Visitors are invited to see how mammals,… / Read More →


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Wooden Chair in Coimbatore
We procure the Wooden Chair which is finest in quality wood to design a durable chair. This intricately designed wooden chair reflects the excellent craftsmanship of our professional. This is widely more...
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Chasu (Glazed Pork Loin)
Total Time
1hr 30mins
Prep 30 mins
Cook 1 hr
This is a flavorful dish and you can use the pork as a main dish or in other recipes. It is very easy. I am posting it for World Tour-2--Asian-China
Ingredients Nutrition
- 1⁄2 cup soy sauce
- 2 tablespoons sugar
- 1 tablespoon molasses
- 4 tablespoons catsup
- 1 tablespoon chopped garlic
- 4 lbs pork loin
- Make sauce with soy, sugar, molasses, catsup and garlic.
- Cut pork loin into 1 1/2x4-inch strips.
- Marinate meat for 2 hours in sauce; store in the refrigerator.
- Bake in oven for 1 hour at 350° basting often.
- Serve with hot mustard on the side.


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Ouachita Parish Sheriff's deputies arrested a West Monroe man last week on charges of simple… Read more
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Men's 5" Golden Retriever® Composite Toe Hiking Boots
Item # WX2-174135
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- Details & Specs
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Men's 5" Golden Retriever® Composite Toe Hiking Boots Fetch yourself adventure - ready comfort and performance!
Loyal companions on the trail! These hiking boots start with the highest quality waterproof, full-grain leather uppers and finish with durable, steady-treading rubber lug traction.
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- ASTM-rated composite toe make this pair of hiking boots work-ready, too (ASTM F2413-05, Class I/75 and C/75)
- Black polyurethane midsole with TPU full foot stabilizer, offers this men's hiking boot maximum comfort and support
- Dri-Lex® covered insole for dry, breathable fitting hiking boots
- Hiker-style padded collar and tongue
- 5". 30 ozs. Brown.
State Size, as available in Shopping Cart.


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Color Mob 5K: Race Entry
Amesbury Sports Park • Amesbury, MA
Saturday, August 24
What you get
- Race Entry for One + Race Bib
- Access to Pre- and Post-Race Party with Live Music & Beer Garden
Whether you're a fitness fanatic or just love a good time, show your true colors with today's deal: Pay $25 ($50 value) to register for the Color Mob 5K held on Saturday, August 24. On the day of the race, gather with other runners of all ages and fitness levels at Amesbury Sports Park. Take off on the 3.1-mile course, where you'll be bombarded with a rainbow's worth of color as volunteers throw colored powder at various points along the course. After you cross the finish line splashed with vibrant hues, make sure to stick around to dance at the after-party.
Fine printREFUND POLICY: This event is nonrefundable. No full or partial refunds are given to customers who miss the event. In the event that Color Mob cancels the event, your voucher will be fully refunded • Registration required online by August 22 • Following registration at colormob5k.com, you will receive an email with additional information • Each voucher is good for 1 person • All ages are welcome; children age 7 and under do not require registration • Participants under 18 must bring a waiver signed by their parent or guardian • Alcohol is not included or discounted in this package • Waiver is available on ColorMob5K.com/waiver • The deal is valid only for tickets on the date of the event as listed and may not be exchanged or redeemed for any other dates • Entire value must be used in a single visit • All racers must to park at the Seabrook Greyhound Park at 319 New Zealand Rd. in Seabrook NH; parking is $10 per car and will include round trip shuttle service to the venue
Other conditions apply
Except where noted in the fine print:
• Cannot be combined with any other offer or promotion
• Tax and gratuity are not included
• Merchant is responsible for the quality of the products or services provided to you at redemption
• LivingSocial Terms and Conditions - https://m.livingsocial.com/terms
Color Mob 5K: Race Entry
times for
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Lindy's diner on 4th elevates the hamburger to an art form. Our menu offers the most creative burgers in town, from the
Two Finger Peek-A-Boo to the Dirty Sanchez Lindy's creates a food experience you will want to experience again and again. You can also enjoy our variety of Philly cheese steaks, chicken sandwiches, or one of our vegetarian burger options. We also offer great cocktails at unbeatable prices. Lindy's Diner on 4th invites you to discover your new favorite hamburger in Tucson.
431 N. 4th Ave. • Tucson AZ 85705
Burger of the Month – The Kevin Metcalf
It's a burger patty topped with mesquite smoked pork butt, thick smoked bacon, coleslaw, pickled jalapeños, sharp cheddar cheese with sweet and spicy bbq sauce on an onion bun.
Hours of Operation
Sunday – Thursday: 11 am – 10 pm
Friday – Saturday: 11 am – 2 am


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'Definite' HHT=3 or more criteria; 'possible' HHT=2 criteria; 'unlikely' HHT if 0 or 1 criteria. HHT, hereditary haemorrhagic telangiectasia.
Neurovascular screening in hereditary haemorrhagic telangiectasia: dilemmas for the paediatric neuroscience community
Version of Record online: 30 SEP 2012
DOI: 10.1111/j.1469-8749.2012.04425.x
© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 55, Issue 5, pages 405–407, May 2013
Additional Information
How to Cite
GANESAN, V., ROBERTSON, F. and BERG, J. (2013), Neurovascular screening in hereditary haemorrhagic telangiectasia: dilemmas for the paediatric neuroscience community. Developmental Medicine & Child Neurology, 55: 405–407. doi: 10.1111/j.1469-8749.2012.04425.x
Publication History
- Issue online: 11 APR 2013
- Version of Record online: 30 SEP 2012
- Abstract
- Article
- References
- Cited By
Hereditary haemorrhagic telangiectasia (HHT) is a dominantly inherited disorder characterized by mucocutaneous telangiectasias and arteriovenous malformations (AVM) in multiple organs, with a frequency of at least 1 in 10 000.1 The most common manifestations are epistaxis, characteristic telangiectasias, and gastrointestinal haemorrhage.2 Neurological features include pial AVM (nidal and micro [nidus <1cm] AVM), high-flow arteriovenous fistulae (AVF) in the brain and spinal cord, capillary telangiectasias,3 and also cerebral ischaemia or abscess due to paradoxical emboli arising via pulmonary vascular shunts. Cerebrovascular malformations (AVM/AVF) affect up to 14% of the HHT population.2 Recent clinical guidelines recommending neurovascular screening4 means that it is timely for awareness of HHT, and the complexities of clinical and genetic diagnosis, to be raised in the paediatric neuroscience community.
Diagnosis of this disorder remains primarily clinical (Table I); individual features carry differential weight in terms of predictive diagnostic power. Three genes have been identified: endoglin (HHT1; OMIM 187300), ACVRLK1 (HHT2; OMIM 600376; which together account for most genetically characterized cases), and SMAD4 (juvenile polyposis/hereditary haemorrhagic telangiectasia syndrome [JPHT] OMIM 175050), with many mutations described. These genes are components of the transforming growth factor beta and bone morphogenic protein signaling pathways.5,6 Two further loci have been assigned HHT3 (OMIM 601101) and HHT4 (OMIM 610655).
|Multiple; lips/nose/oral cavity/fingers
|Visceral lesions
|Gastrointestinal telangiectasia, pulmonary, hepatic, cerebral or spinal arteriovenous malformation
|Family history
|Affected 1st degree relative
Where the diagnosis is beyond reasonable clinical doubt, mutations are detected in 87 to 93% of affected individuals. However, this leaves a significant proportion with a 'definite' clinical diagnosis, and a larger number with a 'possible' diagnosis (Table I legend), without an identified mutation. A combination of epistaxis and family history alone is not a reliable indicator of diagnosis and characteristic skin lesions are rarely present in childhood. Penetrance is age dependent6,7 and children are therefore unlikely to show sufficient features for a clinical diagnosis. This means that, unless genetic testing is informative, all children of a parent with HHT are considered to have possible HHT, even without any phenotypic manifestations.
Some of the excess mortality in HHT, especially in young people, has been attributed to haemorrhage from brain AVMs (BAVMs)2 but data is scant, with a likely ascertainment bias.3,7 BAVMs are more commonly associated with mutations in endoglin than ACVRLK1, with frequencies of 8 to 14% in the former compared with 2 to 3%.8,9 The suggestion that BAVMs in HHT may carry a lower haemorrhage risk than sporadic BAVMs remains contentious.10 Although BAVMs are usually considered congenital,3 as vascular lesions in HHT are thought to represent an aberrant response to angiogenic stimuli2 and spontaneously regressing AVMs have been documented,11 it seems likely that there is also a dynamic component, further supported by frequent presentations during pregnancy.10 It has been suggested that early mortality associated with high-flow AVF explains the discrepancy in age of presentation between these (infancy/early childhood3) and nidal/microAVM (adolescents/young adults); however, overall, high-flow AVFs remain a rare feature of HHT.
Arguments for and against neurovascular screening for children with HHT
- Top of page
- Arguments for and against neurovascular screening for children with HHT
- The role of genetic testing
- To screen or not to screen
- References
Recent international clinical guidelines recommend screening children with definite and possible HHT for cerebrovascular malformations,4 using brain magnetic resonance imaging (MRI) with contrast from 6 months of age or when reviewed. This extends to all children of a parent with HHT, half of whom will be unaffected. The potential benefits and hazards of screening for an asymptomatic disease are complex, but in principle, screening is justified if there is effective presymptomatic treatment. In this context, treatment may be any combination of surgery, endovascular embolization, or irradiation, all of which carry significant morbidity and mortality. For example, Krings et al.12 achieved endovascular obliteration in 38.7% of children with HHT and high-flow pial AVFs, with 6.5% mortality and a similar rate of new neurological deficits. Whilst some BAVMs can be cured, at least 10% may only be amenable to partial treatment and this may encourage evolution to more unfavourable morphologies.13 Once a lesion is detected, this will, even if asymptomatic, cause considerable anxiety, especially if treatment options are limited.
Treatment of asymptomatic sporadic BAVMs in adults remains highly contentious and is the subject of an ongoing randomized trial.14 Most paediatric BAVMs present symptomatically,15 so the risk of haemorrhage in asymptomatic paediatric BAVMs is unknown, although this depends partially on lesion characteristics.16 However, treatment approaches to asymptomatic BAVMs in children have generally been more aggressive based on longer life expectancy relative to adults. If BAVMs in HHT really carry a lower haemorrhage risk, the role of screening is even more complex.
There was only around 65% agreement on the screening recommendation in the guidelines4 and there remain geographical discrepancies in practice, with screening being common in North America but less consistent elsewhere. Some have advocated screening higher-risk patients, for example families with a history of AVM/AVF associated with HHT,2 but phenotypic heterogeneity within families argues against this. Current concepts of the genesis of cerebrovascular malformations suggesting that lesion morphology and extent is determined by the timing and site of a 'second hit' in a genetically predisposed individual17 make familial heritability of BAVM less likely.
Whilst brain MRI and MR angiography will identify larger malformations, smaller lesions can only be reliably excluded on catheter angiography. The clinical relevance of micro AVMs in HHT is unclear but smaller sporadic BAVMs carry higher haemorrhage risk in both adults18–20 and children.16 catheter angiography has an appreciable risk of vascular (5%) and neurological morbidity (0.1%) as well as exposure to ionizing radiation,21 making it unattractive as a screening tool. In a young child, MRI often requires a general anaesthesia. Any identified lesions will require further characterization by catheter angiography. In addition to concerns about side effects of investigation and treatment, single time point screening may be insufficient but issues of when and how often to re-image are unresolved. Spinal AVFs are not discussed in the recommendations but similar considerations apply.
The role of genetic testing
- Top of page
- Arguments for and against neurovascular screening for children with HHT
- The role of genetic testing
- To screen or not to screen
- References
The guidelines suggest pursuing a molecular diagnosis in clinically definite and possible HHT – this would usually be in the parent and should be undertaken via a clinical genetics service, after appropriate clinical assessment and counseling. Currently, molecular diagnosis is achieved in around 70% of such individuals, and in these families asymptomatic family members can have mutation analysis to establish whether they are affected if they so wish. Molecular diagnosis has been shown to be economically beneficial compared with indiscriminate clinical screening of all potentially affected individuals for cerebral and pulmonary arteriovenous shunts.22,23
The place of genetic testing in children is less certain. For children to have presymptomatic testing for a genetic condition, it is accepted that there should be a clinical benefit to this testing for the child24 (http://www.bshg.org.uk/documents/official_documents.htm). Avoidance of an invasive screening test would be an appropriate indication. However, in childhood, screening for the major treatable complication, pulmonary arteriovenous malformations (PAVMs) should usually be performed after puberty, as lesions tend to evolve under hormonal influence. Screening of asymptomatic children before puberty is often restricted to pulse oximetry to exclude detectable hypoxia. PAVM screening, does not, therefore provide a good reason for childhood testing. A molecular diagnosis in childhood might also have major financial implications for the individual when they reach adulthood, for example with access to life and health insurance. Unless, therefore, there is a reasonable case for benefit to the child, molecular testing should be deferred until they can make the decision about testing for themselves.
As the likelihood of BAVM is higher in those with endoglin compared with ACVRLK1 mutations, formal risk- and cost-benefit analyses would favour screening patients with an endoglin mutation (where approximately 10 scans will be performed for every lesion identified) than those with an ACVRLK1 mutation (where approximately 50 scans will be performed per lesion identified). These relative frequencies may also influence a family's choice about whether or not to opt for neurovascular screening. In a family without a known mutation, it is important to be certain about the clinical diagnosis, as there are a number of other hereditary vascular dysplasias that can be confused with HHT, including capillary malformation arteriovenous malformation syndrome (CM-AVM, OMIM 608354), familial cerebral cavernous malformations (FCCM, OMIM 116860), and venous malformations, multiple cutaneous and mucosal (VMCM, OMIM 600195). Review by an experienced clinician and gene testing can be very effective in establishing the correct diagnosis.
To screen or not to screen
- Top of page
- Arguments for and against neurovascular screening for children with HHT
- The role of genetic testing
- To screen or not to screen
- References
It is unfortunate that a recommendation in favour of neurovascular screening has been made despite the lack of supportive evidence of efficacy; the level of agreement within the expert group suggests that there is near equipoise as to whether or not this is a valid strategy. Nonetheless, now the recommendation has been made, clinicians will need to deal with expectations from both patients and professional colleagues in practical terms.
In our view, where the issue of neurovascular screening for definite or possible HHT arises, the child and family (after a thorough genetic characterization and prior to any neuroimaging) should be referred to an experienced paediatric neurovascular team conversant with the above issues for counseling. Potential contributors to such a team might be paediatric neurologists, neurosurgeons, and interventional neuroradiologists. The issues that should be covered include: likely frequency of BAVM, lack of evidence favouring treatment of asymptomatic lesions, treatment related morbidity, and the possibility of identifying small/untreatable malformations or other incidental intracranial findings (e.g. arachnoid cysts). It should be made clear that small lesions may not be detected and that the identification of a vascular malformation may have significant wider impact, for example for future insurability.
Should the family wish to proceed, MRI of the brain and spine could be performed. Gadolinium enhancement will increase conspicuity of small vascular lesions, adding weight to a positive diagnosis, although these lesions are unlikely to be suitable for treatment. Given potential dynamic factors in development of cerebrovascular malformations in HHT, it seems reasonable (until more definitive data is available) to discuss the option of re-imaging in adult life if the index scan was during childhood. This may be especially important in females as symptomatic haemorrhages appear to cluster around child-bearing years.10
Given the current dearth of evidence, it is essential that any systematic approach to screening is evaluated in a prospective manner; this is likely to require multi-center and probably international collaboration. Such a strategy has potential to give rise to a variety of difficult clinical scenarios and the involvement of an experienced specialist team from the outset will facilitate onward management.
Perhaps most importantly, adults with HHT should be educated about the potential presentation of a cerebrovascular lesion in their children. This may include cardiac failure in newborns (tachypnea, sweating, failure to thrive), hydrocephalus in infants (enlarging head size, sunsetting), or acute focal neurological deficits from cerebral haemorrhage or venous ischaemia at any age (seizures/hemiparesis). Empowering parents with this information will mean that such presentations are recognized and acted on swiftly, both by parents and healthcare professionals.
Children presenting de novo with neurovascular malformations (and their families) should be evaluated in detail for clinical features of HHT. This includes taking an extended pedigree and enquiring about specific non-neurological symptoms, such as epistaxis or gastrointestinal haemorrhage, as well as detailed clinical (including cutaneous) evaluation. Radiological flags for potential HHT include multiple cerebral AVM25 and high-flow cerebral or spinal AVF, especially in infants.3 In this context, genetic testing may frequently be applicable and useful in management for the wider family.
- Top of page
- Arguments for and against neurovascular screening for children with HHT
- The role of genetic testing
- To screen or not to screen
- References
- 1The prevalence and manifestations of hereditary hemorrhagic telangiectasia in the Afro-Caribbean population of the Netherlands Antilles: a family screening. Am J Med Genet A2003; 116A: 324–8., , , .
- 2Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev2010; 24: 203–19..
- 3Neurovascular phenotypes in hereditary haemorrhagic telangiectasia patients according to age. Review of 50 consecutive patients aged 1 day–60 years. Neuroradiology2005; 47: 711–20., , , , , .
- 4International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet2011; 48: 73–87., , , et al.
- 5Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations. Blood2010; 116: 1604–12., , , et al.
- 6Endoglin in angiogenesis and vascular diseases. Angiogenesis2008; 11: 79–89., , .
- 7Intracranial hemorrhage in infants and children with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome). Pediatrics2002; 109: E12., , , et al.
- 8Hereditary haemorrhagic telangiectasia: a questionnaire based study to delineate the different phenotypes caused by endoglin and ALK1 mutations. J Med Genet2003; 40: 585–90., , , et al.
- 9Genotype-phenotype relationship in hereditary haemorrhagic telangiectasia. J Med Genet2006; 43: 371–7., , , et al.
- 10Should asymptomatic patients with hereditary haemorrhagic telangiectasia (HHT) be screened for cerebral vascular malformations? Data from 22,061 years of HHT patient life. J Neurol Neurosurg Psychiatry2003; 74: 743–8., , , , , .
- 11Spontaneous regression of a cerebral arteriovenous malformation in a child with hereditary hemorrhagic telangiectasia. Case report. J Neurosurg2006; 105: 428–31., , .
- 12Hereditary haemorrhagic telangiectasia in children. Endovascular treatment of neurovascular malformations. Results in 31 patients. Interv Neuroradiol2005; 11: 13–23., , , , , .
- 13How to deal with incompletely treated AVMs: experience of 67 cases and review of the literature. Acta Neurochir Suppl2011; 112: 123–9., , , et al.
- 14The ARUBA trial: current status, future hopes. Stroke2010; 41: e537–40., , , et al.
- 15Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations. Stroke2005; 36: 2099–104., , , et al.
- 16Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformations. J Neurointerv Surg2012. Mar 13 [Epub ahead of print]., , , et al.
- 17Classification and endovascular management of pediatric cerebral vascular malformations. Neurosurg Clin N Am2010; 21: 463–82., , .
- 18Arteriovenous malformations of the brain: natural history in unoperated patients. J Neurol Neurosurg Psychiatry1986; 49: 1–10., , , .
- 19Bleeding from cerebral arteriovenous malformations as part of their natural history. J Neurosurg1983; 58: 331–7., , .
- 20Intracranial arteriovenous malformations. Conservative and surgical treatment. J Neurosurg1980; 53: 149–52., .
- 21Complication rates of diagnostic cerebral arteriography in children. Pediatr Radiol2005; 35: 1174–7., , , , .
- 22Cost savings through molecular diagnosis for hereditary hemorrhagic telangiectasia. Genet Med2012; 14: 604–10., , , , .
- 23Cost comparison of genetic and clinical screening in families with hereditary hemorrhagic telangiectasia. Am J Med Genet A2005; 137: 153–60., , , , , .
- 24Presymptomatic and predictive genetic testing in minors: a systematic review of guidelines and position papers. Clin Genet2006; 70: 374–81., , , , .
- 25Brain arteriovenous malformation multiplicity predicts the diagnosis of hereditary hemorrhagic telangiectasia: quantitative assessment. Stroke2012; 43: 72–8., , , et al.


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Now with 2008 upon us, many fans are still anxiously awaiting for his sophomore effort from Foreign Exchange and his second volume of Dutch Masters. Since the launch of his new label last year (Nicolay Music Recordings), "Time:Line" is his first official independent release. Similar to "Connected", Nicolay shares the boards with Houston rapper Kay in a conceptual journey through the time of one's life: birth, death and afterlife.
"Time:Line" - The intro of the album with Kay pretty much describing himself, which sets the tone for the rest of the album. The arrangements sound like it could be used for a Gnarls Barkley track.
"Blizzard" - Full of old school vintage, I could see the hip-hop duo Camp Lo spittin' over this funky tune. Toby Hill adds some nice vocals as Kay describes his birth and childhood nostalgia.
"The Lights" - The life of a struggling superstar caught up in the sensationalism and hype of being famous, now slowly succumbing the pressures of drugs and materialistic gain.Read more ›
In a commercially-woven "rapestry" fixated on bejeweled, Bentley-driving blingsters with infinitely more money than sense, the genre has - in large part - become more a celebration of bombastic cliché than a collective of sublime creativity. Where NWA and Public Enemy painted groundbreaking, original pictures of an urban reality as yet unseen, today's pseudo-poets do little more than glamorize it for personal gain or product spin-offs, content with marketing to the lowest common denominator. Whew - I could use a Vitamin Water®.
But perhaps not all hope is lost. There is a largely unreported, parallel universe in hip-hop that does occasionally render a glimmer of hope. Living in this altered state are Dutch producer Nicolay and Houston-based MC, Kay. Their collaboration, titled Time:Line charts a semi-autobiographical character arch from life, to death and there-after.
Demonstrating a deft - if not sometimes heavy - hand for blending samples with live instruments, Nicolay lays a rich, musical foundation for Kay's lyrical rhymes. Kay's tone and cadence are at once fluid and assertive without being abrasive; his lyrics personal and vivid, but not above humor and self-deprecation. N & K aren't necessarily breaking any new ground with Time:Line, but what they have assembled is a competent, heartfelt collection that flows easily from start to finish.Read more ›
In terms of production, it's not Nic's best work, but it's still dope. The problem, if you can call it that, is Kay. While he's serviceable over Nicolay's production, he's very by-the-book with it and, as a result, he has trouble holding the attention of this particular listener. I don't know, maybe it's because I prefer hearing Nic's beats without lyrics. His 2005 release, City Lights, Vol. 1.5, is near classic in my book if not a bonafide classic.
Time:Line is a nice listen. It was underwhelming in spots, but it's still purchase worthy. Nicolay is still true to form on the boards and Kay, while coming up short in the charisma department, does manage to hold the album down for the most part. I'd recommend checking out the samples to make sure he's your cup of tea. If he passes the sample test, then you're in for a nice ride.
Standout Tracks: Through The Wind, What We Live, Tight Eyes (My Favorite), Blizzard, and I've Seen Rivers
Kay is a very good rapper, and adds a matching soulful flow to compliment the production. With that said though, he isn't quite spectacular enough to call this record a classic...as the production over powers his skills. Standout tracks include the guitar driven "Blizzard", the atmospheric "The Lights" with simply soothing background vocals from Nicole Hurst; "Through the Wind" boasts one of Nicolay's most infectious beats and Kay adds some excellent lyrics to match. The horn-filled "What We Live" stands out nicely. "The Gunshot" tackles raggae styled production excellently with the Fu-Schnickens' own Chip Fu making an appearance. "Grand Theft Auto" is also one of my favorites here, which features some of Kay's best lyrics.
On the whole, Nicolay & Kay turn out an excellent full-length virtually free of flaws. In all honestly, Kay is the reason this doesn't get the 5-star rating from me, since Nicolay's production is classically banging throughout. Simply put, Kay is no Phonte. Even still, don't let that deter you from checking out one of the best hip-hop albums of 2008.
Most Recent Customer Reviews
Love the feeling and sounds of this album and the lyrics are on point I think this is some of Nicolays best production outside of foreign exchange. Read morePublished on December 19, 2012 by Jason
WOW JUST GOOD MUSIC BLEW ME AWAY PURE ARTIST SO REFRESHING TO HEAR IF YOUR A TRIBE DE LA J DILLA SLUM VILAGE FAN YOU MUST HAVE THIS !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!Published on January 11, 2011 by TIGHT EYES
I can't even describe how much I enjoyed this album. The beats are incredible, the lyrics are original - Nicolay and Kay make a perfect team. Read morePublished on May 24, 2009 by Lena D
Nicolay out did himself on this one. Its a lot better than the Here ablum.The production is amazing. You wont be disappointed.Published on December 22, 2008 by Mr. Smiff
BOTTOM LINE: Nicolay is the Betterman from the Netherlands! His musical catalogue is growing more impressive with each CD release. Read morePublished on July 8, 2008 by Big Willy
This is an oasis in a Hip Hop desert.
The beats are far more interesting and exciting than 99% of what is happening in Hip Hop these days. Read more
Not many albums are listenable from front to back nowadays. This one is. The combination of Kay and Nicolay is a treat. Highly recommended!Published on May 17, 2008 by DBDR


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The day after David Miliband announced that an Israeli diplomat would be expelled from Britain, British Ambassador Tom Phillips made the rounds in Jerusalem trying to promise that the ties between the two countries, especially those regarding intelligence, would remain strong.
The same could be heard from Israeli sources: this was regrettable, but the British did what they had to. It could have been worse.
That is true. The Foreign Office has not named and shamed the Mossad representative in London, who is being given time to leave in an orderly fashion, after Pesach.
Young Israelis are keener than ever to join army combat units, according to new Israel Defence Forces figures.
After a barrage of criticism by human rights organisations and the Goldstone Report in the wake of the Gaza War, the reputation of the Israeli army's combat units have taken a battering.
But among Israeli school leavers, the three-week military campaign appears to have done wonders for their image.
Three years ago, Jerusalem rabbi David Bar-Hayim sent shockwaves through Israeli Orthodoxy after convening a beth din which ruled that all Israelis may eat kitniyot on Passover.
Now, he has come to the conclusion that the ruling should also apply to English Jews.
As well as following the Biblical law of avoiding chametz on Passover, Ashkenazi Jews observe a medieval tradition of also steering clear of numerous foods classified by rabbis as kitniyot, their term for pulses and legumes.
Police have recommended that no criminal charges should be brought against one of Israel's leading rabbis, Motti Elon, for homosexual encounters with young men who sought spiritual guidance.
According to the police, all the cases they investigated involved consensual acts with men over 18.
The Attorney General, Yehuda Weinstein, is expected to accept the police recommendation.
The investigation was launched into Rabbi Elon last month after a forum of senior rabbis and educators, Takana, announced that he had been accused of sexual impropriety.
For once, elections in Israel are not even on the horizon. By law the country will not have to go to the polls for another three years and a coalition crisis is not even on the cards.
Even if Binyamin Netanyahu's current right-wing partners turn against him, he can still join forces with Kadima and form a new centrist coalition.
Still, this relatively stable political landscape has not stopped the Israeli media and parliament feverishly speculating about a political upheaval: the emergence of a force that may rearrange the balance of power in the Knesset.
Binyamin Netanyahu was forced to take time out from his Washington trip this week to order a review of a government decision to relocate a new emergency ward planned for an Ashkelon hospital, at a cost of NIS 136 million (£24 million).
A Knesset member has compared the British to "dogs" and claimed the UK government has no right to judge Israel.
MK Arieh Eldad, a member of the extreme right-wing National Union party, was expressing his anger over Britain's apparent decision to expel an Israeli diplomat after an investigation by the Serious Organised Crime Agency into the forging of British passports.
The passports were used by a hit squad which killed a Hamas terrorist in Dubai.
The Knesset may scrap a bill which had the backing of Sir Paul McCartney, to forbid the manufacture, import and export of all kinds of furs.
MK Zevulun Orlev, who chaired a coalition committee discussion on the bill, said pressure from the Charedi community, from MK Menachem Eliezer Moses and from the Shas Party had led to the bill being temporarily shelved.
Mr Orlev said: "I have no interest in offending the Charedi public".
The Middle East Quartet peace mediators have called on Israel to freeze all settlement activity and say their aim is to create a Palestinian state within two years.
UN Secretary General Ban Ki-Moon, who led the meeting with representatives from the US, the European Union and Russia, was the latest to condemn Israel's plan to build 1,600 homes in Ramat Shlomo, east Jerusalem.
Professor Stanley Fischer has agreed to serve a second five-year term as Governor of the Bank of Israel, providing a potentially enormous boost for the Israeli economy.
Such is his international eminence that when he accepted the offer to become head of the Bank of Israel in 2005, it was likened to Michael Jordan agreeing to play basketball for Maccabi Tel Aviv.


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Mass density, dielectric, elastic, and piezoelectric constants of bulk GaN crystal were determined. Mass density was obtained from the measured ratio of mass to volume of a cuboid. The dielectric constants were determined from the measured capacitances of an interdigital transducer (IDT) deposited on a Z-cut plate and from a parallel plate capacitor fabricated from this plate. The elastic and piezoelectric constants were determined by comparing the measured and calculated SAW velocities and electromechanical coupling coefficients on the Z- and X-cut plates. The following new constants were obtained: mass density p = 5986 kg/m3; relative dielectric constants (at constant strain S) ε11S/ε0 = 8.6 and ε11S/ε0 = 10.5, where ε0 is a dielectric constant of free space; elastic constants (at constant electric field E) C11E = 349.7, C12E = 128.1, C13E = 129.4, C33E = 430.3, and C44E = 96.5 GPa; and piezoelectric constants e33 = 0.84, e31 = -0.47, and e15 = -0.41 C/m2.


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Hillbilly Shootin Irons
we specialize in hard to find Reloaded Ammo for Handguns and Long guns. 92 different calibers are available.Also can teach the art of reloaded, one on one lessons. We buy and sell Firearms
we specialize in hard to find Reloaded Ammo for Handguns and Long guns. 92 different calibers are available.Also can teach the art of reloaded, one on one lessons.
We buy and sell Firearms
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July 22, 2005 -- Rozerem, the first of a new kind of sleeping pill, has been approved by the FDA.
Before this approval, many sleeping pills had potential narcotic-like effects. True, new nonbenzodiazepine sleeping pills -- such as Ambien, Lunesta, and Sonata -- have greatly reduced abuse potential. But they still have a sedating effect throughout the brain. And like earlier sleep drugs, they are controlled substances under federal law.
Rozerem (8-milligram tablets) is the first and only noncontrolled prescription medication for use of insomnia in adults. It is prescribed for insomnia characterized by difficulty with sleep onset.
Rozerem can be prescribed for long-term use. The medication has shown no evidence of abuse and dependence, according to a news release by Takeda Pharmaceuticals North America, the drug's maker.
Rozerem is different from other sleep drugs. It targets specific switches in the part of the brain that regulate sleep, a group of brain cells located in an area of the brain called the SCN. By flipping these switches -- called melatonin receptors -- Rozerem takes the brakes off the body's natural sleep drive.
Body Boot-Down
Here's how it's thought to work. The body has a sleep drive as well as a waking drive. As the day wears on, the sleep drive builds up. But it doesn't make you fall asleep in the daytime, because that's when the waking drive is stronger. Later in the evening, the waking drive winds down while the sleep drive continues to build up. By bedtime, the sleep drive is stronger -- and you're ready for normal sleep.
If you've got insomnia, the sleep and waking drives get out of balance. Most sleeping pills work by enhancing the sleep drive. Rozerem seems to work by relaxing the waking drive, says psychiatrist Louis J. Mini, MD, Takeda North America's medical director for neuroscience.
"In people who sleep normally, the pineal gland in the brain responds to darkness by producing a hormone called melatonin," Mini says. "This natural melatonin ... dampens the alerting signal so the sleep load overrides [the waking drive] and allows a person to fall asleep."


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Prithviraj Sukumaran (born 16 October 1982), credited mononymously as Prithviraj, is an Indian actor, playback singer and producer best known for his work in Malayalam films. He has also acted in a number of Tamil, Telugu and Hindi films and has been... described as one of the few actors in India who is able to achieve pan-Indian appeal.
Connect any celebrity with Prithviraj Sukumaran to see how closely they are linked... romantically!


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Search: smart-asserySearch profiles »
anamnesis_allMatch % Unknown Join to find out!
Although, there will probably some smart-assery in my answers, along with wit and sarcasm . ("Smart-assery" is now a word in my book.
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Cooking, trivia, and smart-assery
PsyberneticMatch % Unknown Join to find out!
Video games of the non-twitch variety, languages, smart assery, and perhaps lying about things I'm good at.I know you're thinking, "oh no, a gamer, ew," but since I hope to get into game development, I view it as research. Regarding smart assery, get me with the right group where I feel comfortable
QuasarKittyMatch % Unknown Join to find out!
Smart-assery as a weapon against fuck-wittery.
Aka_kungfubarMatch % Unknown Join to find out!
Oxygen, sunlight, carbon-based organic matter, thumbs, a frontal lobe and smart-assery.I *can* refrain from smart-assery, but prefer not to.
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68 for me..........
Is this when you tell us your Oscar had 701 babies? :)
Last edited by Lady Hobbs; 10-05-2012 at 03:18 AM.
Cycling With Fish? The Fishless Cycle
Goldfish Growth Expectancy
Forum Rules
I am in the label printing business and I have a
salt water aquarium. I cam up with these labels
and ...
Welcome to Aquarium Home Farm Center, a
professional breeder of the Dragon Fish, the Asian
Red Arowa ...
I am the owner of Custom Acrylic Reef. We can
build your dream custom acrylic aquarium and then
set ...


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Got to be Happy with that
Was blown away today when I checked my email and was notified of the purchase of not one but four pieces of my photography work by nicemittens, who is only here to shop it would appear!
1x Canvas Print of Geneva Lake Divers / Extra Large
1x Canvas Print of Geneva, Lake, Summer. – Untitled No.2 / Small
1x Canvas Print of Geneva, Lake, Summer. – Untitled No. 3 /Small
1x Canvas Print of We That Never Sleep / Medium
I am also humbled to note the company that I am keeping amongst nicemittens favouriting of artists and work. This represents the single most successful day I have had here on the bubble sales wise with my photography, and thought it was certainly journal worthy at the very least!
Woohoo! :)


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Posted| Updated
Adelaide police have charged two people with the murder of their intellectually-disabled daughter.
The woman, 27, died at her home at Brighton North last March.
Topics: murder-and-manslaughter, crime, law-crime-and-justice, disabilities, health, sa, brighton-5048, adelaide-5000, australia
Posted| Updated
People watch as poppies fall from the sky after being dropped from a helicopter during the Remembrance Day commemorations at Brighton Secondary School in Adelaide on November 11, 2011.
Topics: community-and-society, brighton-5048
Posted| Updated
Thousands of artificial poppies were dropped over a remembrance service at Brighton in Adelaide, an idea suggested by a 14-year-old student.
Topics: veterans, world-war-1, history, community-and-society, education, event, unrest-conflict-and-war, brighton-5048, adelaide-5000, sa
Posted| Updated
Onlookers are showered with artificial poppies at a remembrance service at Brighton in Adelaide
Topics: veterans, world-war-1, history, community-and-society, event, unrest-conflict-and-war, brighton-5048, adelaide-5000, sa
A helicopter flies over Adelaide, dropping its load of artificial poppies.
Topics: veterans, world-war-1, history, community-and-society, history-education, unrest-conflict-and-war, event, brighton-5048, adelaide-5000, sa
Thousands of artificial poppies cover the ground after they were dropped from a helicopter over Adelaide.
Topics: veterans, history, community-and-society, event, education, brighton-5048, adelaide-5000, sa
Posted| Updated
Remembrance Day has been marked in Adelaide with a helicopter drop of 102,000 poppies.
Topics: history, community-and-society, world-war-1, community-education, education, unrest-conflict-and-war, sa, brighton-5048, adelaide-5000
Posted| Updated
A man is being treated for burns after a gas explosion at a home unit at Paradise in Adelaide's north-eastern suburbs.
Topics: residential, fires, disasters-and-accidents, sa, paradise-5075, adelaide-5000, brighton-5048, swan-reach-5354
Posted| Updated
An Adelaide Catholic priest accused under parliamentary privilege of sexually abusing a man, now an Anglican archbishop, has spoken publicly for the first time to deny the allegation.
Monsignor Ian Dempsey was named in the Senate by independent senator Nick Xenophon.
Senator Xenophon said the Archbishop of the Traditional Anglican Communion, John Hepworth, alleged he was abused by the priest while studying in a Catholic seminary.
Topics: catholic, religion-and-beliefs, community-and-society, laws, law-crime-and-justice, brighton-5048, adelaide-5000, sa, australia
Posted| Updated
Topics: weather, brighton-5048, adelaide-5000, sa
Minda Incorporated has decided against building retirement homes on environmentally-sensitive sand dunes at Brighton in Adelaide.
Topics: environmental-impact, aged-care, community-and-society, environment, environmental-policy, housing, brighton-5048, adelaide-5000, sa
Posted| Updated
Police are investigating the apparent death by malnutrition of a woman who weighed just 11 kilograms.
Topics: diet-and-nutrition, community-and-society, health, doctors-and-medical-professionals, womens-health, law-crime-and-justice, brighton-5048, australia, adelaide-5000, sa
Taking in the sunset from Brighton Jetty, in South Australia, on February 14, 2011.
Topics: human-interest, sa, brighton-5048
Posted| Updated
Police have laid several charges against a 15-year-old boy who allegedly took a samurai sword into Brighton Secondary School in Adelaide.
Topics: police, family-and-children, emergency-incidents, schools, secondary-schools, law-crime-and-justice, brighton-5048, sa
Posted| Updated
A 15-year-old student is facing several charges after a lockdown at Brighton High School in Adelaide.
Topics: education, schools, crime, antisocial-behaviour, police, brighton-5048, sa
Posted| Updated
A local MP and a disability association are at odds over a housing plan at Brighton in Adelaide's south-west.
Topics: urban-development-and-planning, community-and-society, government-and-politics, states-and-territories, brighton-5048, adelaide-5000, sa
Two boys, 14 and 17, have been arrested over robberies at two Adelaide high schools.
Topics: armed-robbery, schools, law-crime-and-justice, crime, brighton-5048, australia, adelaide-5000, sa
Posted| Updated
Labor MP Chloe Fox has pulled ahead of Liberal challenger Maria Kourtesis in the only seat the Liberals could still snatch from the ALP in the South Australian election.
Topics: elections, government-and-politics, political-parties, alp, liberals, states-and-territories, brighton-5048, australia, adelaide-5000, sa
An Alberton man, 28, has been arrested over a car crash into a house at North Brighton.
Topics: crime, road, law-crime-and-justice, brighton-5048, adelaide-5000, sa
A man and a woman have been charged over two armed hold-ups in Adelaide this week.
Topics: armed-robbery, law-crime-and-justice, crime, brighton-5048, adelaide-5000, sa, seacliff-5049, seacliff-park-5049
Posted| Updated
Two customers of an Adelaide pharmacy have made a return visit - this time to steal drugs.
Topics: armed-robbery, law-crime-and-justice, crime, brighton-5048, adelaide-5000, sa, plympton-park-5038, seacliff-park-5049
Posted| Updated
A teenager has been found not guilty of killing footballer Sam Davis with a single blow to the head.
Topics: courts-and-trials, adelaide-5000, sa, brighton-5048
Posted| Updated
The only witness said to have seen a fatal attack suffered by Sam Davis at a party in Adelaide has given evidence.
Topics: courts-and-trials, law-crime-and-justice, sa, adelaide-5000, brighton-5048
Posted| Updated
A witness has told SA's Supreme Court he saw an argument involving his friend before his friend was allegedly fatally bashed.
Topics: courts-and-trials, adelaide-5000, sa, brighton-5048
Posted| Updated
South Australia's Supreme Court has heard a teenage boy was killed by an aggressive bully who was looking for a fight.
Topics: courts-and-trials, brighton-5048, adelaide-5000, sa


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An Outlook About Sex And Virginity Issues With Filipina Girls
Any kind of these ideas sound familiar? If you end up being anything like any millions of older men who have digest our articles during sensational Brisbane a lot more the years... the truth is, they probably choose. After all, no matter the correct way much sexual liberation there is for the world the following days, the fast fact remains, that MUCH of so what women really would love in bed remains a mystery to men. (But NOT to us).
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Some of these questions predicament? In this short account we are gonna be take a fast and easy look a few time of the most frequent questions men enquire about SEX, and specifically, how it relates to your ability to impress your partner operating in bed, so lady doesn't' leave unfulfilled, unhappy and interested in something more... somewhere else!
• You can have engaging in this particular sex in many kinds of positions, by taking turns. Carbohydrates go on finest sometime and then ask your significant other to switch over. Through this, you can conserve the spirit and excit of such connected with sex.By oscardaexeuxtuuxvbfd
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Be respectful, keep it clean.


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Columbus, OHUSA
October 2, 2012
5 ish
No introduction yet
Hola and bienvenido, If you had a smattering of Spanish in high school or college, are fluent, or just want to tag along and see what you can pick up - this is the group for you. Gracias!
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Edited with KDENLIVE 0.8.2.1
If you have you tube account you can put (I Like).
If you don't have you tube account you can only click.
(I Like) means 5 points for me.
(Click) means 1 point for me.
If you want you can share with other social networks.
Contest will expire 2012/16/03
Thanks in advance !!


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Could bactroban 2% cream be used to cure a vaginal yeast infection?
- Posted:
- 8 Nov 2009 by jogabb
- Topics:
- bactroban, infections, vaginal yeast infection
Answers (1)
8 Nov 2009
Unfortunately No, it is antibiotic and you need an antifungul, like Monistat. They even have store brand now that is cheaper. Yeast infections are cause when the good bacteria that we all have are down and the yeast can then grow unchecked. When women who are prone to yeast infections take antibiotics, they often get yeast because of the good bacteria getting killed off. Birth control pills, wearing wet swimsuits and over indulging in alcoholic beverages and sweets also tend to cause them. Use mild soap to cleanse with and use one of the Monistat or store brand anti yeast medication kits with the cream for the outside skin and you should be much better in 48 hours. Vagisil will help with the skin irritation also, just don't glob either medicine on the skin, it actually needs to breathe.
Further Information
- Bactroban Information for Consumers
- Bactroban Information for Healthcare Professionals (includes dosage details)
- Side Effects of Bactroban (detailed)
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Skip The Wax: DIY Honey Hair Remover!
3 Ways To Make Your Own Homemade Natural Shampoo
This is Why Your Edges Are Breaking
3 Different Ways To Follow the Curly Girl Method
Haircuts That Make You Look Thinner
3 Secrets to Growing Long Natural Hair
Steal These Matte Lip Looks from the Runway
The 10 Best Concealers for Darker Skin Tones
7 DIY Beauty Products That Will Make You Swear Off Sephora
Hair Shrinkage Tips You Can't Live Without
41 Cool Wrist Tattoos to Inspire Your Next Ink Session
Brighten Your Mood With MOODmatchers!
The Perfect Hairstyle To Save Your 3rd Day Curly Hair
How to Get Rid of Grey Hair Naturally!
How to Wash Box Braids Without Ruining Them
Quick Ways to Care For Natural Hair at Bedtime
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Glam Transitioning Hairstyles For Black Women
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How To Fix Your Greasy Scalp Situation With Rosemary Oil
A Guide to Helping Homeless Cats Through the Winter
How To Fake an Afro for a Day
A Pretty Farm to Table Wedding


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Web Naturheilpraxis - repost
This project received 20 bids from talented freelancers with an average bid price of $576 USD.Get free quotes for a project like this
Project Budget$250 - $750 USD
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Project Description
Realise a Web.
I give you Wireframes, Photoshop pixeal accuracy, Pictures und briefing by Skype and deskshare.
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Judge allows former town manager's appealSeptember 18,2013The Associated Press
ST. JOHNSBURY - A judge has cleared the way for a former St. Johnsbury town manager to take his bid to get his job back before the Vermont Supreme Court.
Judge Mary Miles Teachout's ruling Monday allows Ralph Nelson to seek an appeal of Teachout's decisions on some aspects of the lawsuit.
Nelson's lawyer has argued that the issues involved in Nelson's lawsuit are relevant to towns and town managers statewide.
At issue is Teachout's prior ruling that Nelson was an "at will" employee and eligible to be fired at any time for any reason. In doing so, Teachout interpreted the Vermont statute governing town managers, for which there was no prior case law.
Nelson was town manager for 19 months before being fired in April 2012.MORE IN This Just In
Emergency crews Thursday found two hikers from Vermont who spent the night lost... Full Story
BENNINGTON — The annual Southern Vermont Garlic and Herb Festival, now in... Full StoryBRANDON The towns annual summer townwide yard sale, one of the biggest in the state, will take... Full Story
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Articles - Recent Comments
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Instant Expert: Secrets & Features of iTunes 12
What a load of horses**t this article is. How can itunes 12 be easy to use when you have to look at a guide to do even the most simple things. it's a rubbish upgrade which is what we are begining to expect of apple these days.
Posted by Billy on December 10, 2014 at 4:48 AM (CST)
An Easy Guide To Setting Up + Using Apple Pay In iOS 8.1
How can I add loyalty cards into Passbook on IOS 8.1.1. such as BJ's or Costco's. I do not want to use Pass Source. Want to be able to scan the barcode and add into Passbook on my iphone 6+
Posted by Anthony Hart on November 19, 2014 at 12:49 PM (CST)
Instant Expert: Secrets & Features of iOS 8.1
Up until I purchased an iPhone 5, I rarely had battery problems. Suddenly, with the iPhone 5 I was constantly searching for plugs, so I upgraded to the S because it was supposed to have a better battery—no noticeable difference. I bought a Moshi battery case and never had to worry about battery issues again. I upgraded to the 6 and I swear the battery is worse than either the 5 or 5s. I hate to buy another clunky battery case for the super thin and sleek 6. Why doesn't Apple place a higher priority on battery life. I wish a site, such as iLounge, would run a survey structured to determine how users would prefer Apple prioritize various features with a rundown on the features describing their impact on size and weight. We need a respected means of being heard on these issues.
Posted by Nan Roth on November 8, 2014 at 3:37 PM (CST)
What's New in iTunes 12
I've asked why they removed the cover view window as now its nearly impossible to see quickly if a file has a picture or not. Before you just chose the file and it showed up in the cover view window. Now you have to open the file, goto the cover view and check manually.
I'm really thinking of deleting iTunes 11 and downgrade to iTunes 10 as thats the last of the good iTunes.
Posted by NakedFaerie on November 2, 2014 at 9:39 PM (CST)
iLounge's Top iPhone 6 + iPhone 6 Plus Case Picks (Fall 2014)
After having used the iPhone 6 Plus Griffin Survivor All-terrain for about a week, and I disagree with part of your review when you say it makes the device hard to hold. I've found the exact opposite. I feel as if the grip is much improved. I agree about pocket ability, however, in jeans it's not a real issue.
Posted by John C on October 31, 2014 at 12:33 PM (CDT)
Instant Expert: Secrets & Features of iOS 8.1
With my iOS 8.1 on iPhone 5s pictures sent by iMessage a revert to unedited form. Also, many pictures are now blurry. Any ideas on what to do to fix this?
Posted by Chris Midkiff on October 26, 2014 at 8:46 PM (CDT)
What's New in iTunes 12
If you are referring to the mini player, then just click the artwork on the left of the now playing window.
I don't have access to my iMac at the moment, so can't give exact details, but I know that this can then be reduced further, removing, the artwork, by clicking something within the mini-player.
Posted by Stephen on October 25, 2014 at 4:20 PM (CDT)
What's New in iTunes 12
Am I missing something or is the small controller window gone?
Posted by Ted Wilder on October 25, 2014 at 10:34 AM (CDT)
What's New in iTunes 12
I have tried repeatedly to get a response from Apple support (with no luck) about why they took away the "view all" feature from the Wish List. Had a lot of items saved there but now cannot view anything beyond the latest selections. What's the point of having a wish list if you cannot see all the items saved to it?!?
Posted by John Byrne on October 23, 2014 at 8:45 PM (CDT)
What's New in iTunes 12
#17 TW - is it any use to edit Description Field directly, instead of going through Get Info ? You can edit it directly, albeit only one tune at a time it seems.
Posted by Anon on October 23, 2014 at 1:02 PM (CDT)
What's New in iTunes 12
is there a way to edit the description field in the get info menu i use this to manage my large (135.000 track) library creating smart playlist from the the information i have adding in this field (description) that appears to be missing in iTunes 12 failing this is there a 3rd party app that will let me edit this field?
Posted by tony wilkinson on October 22, 2014 at 1:36 PM (CDT)
What's New in iTunes 12
now my books and Music show in the same place,anyone found a way to hide books
Posted by DOC on October 22, 2014 at 9:05 AM (CDT)
What's New in iTunes 12
Can not find airplay icon anymore on itunes 12!!!
Posted by Myri on October 22, 2014 at 3:12 AM (CDT)
What's New in iTunes 12
Getting album art is much less convenient in 12. Can't seem to copy and paste from the web directly into info anymore. Have to download the image then add it from your computer.
Also wish the pop-out player would allow for much larger sizing, if not whole screen. Why not ?
Posted by Anon on October 21, 2014 at 4:30 PM (CDT)
What's New in iTunes 12
Worst. App. Update. Ever.
Having to click on the movies button (or music etc.) THEN click on the store button to get that file type to show up in the store is completely worthless.
But the worst part of this app: taking away the side bar so you can't see all your file types at once! I think the Apple designers did this just to make themselves feel busy. Seriously, worst app update in the history of Apple. Shame on you all for this monstrosity being released on the world.
Posted by cj on October 21, 2014 at 1:05 PM (CDT)
What's New in iTunes 12
I hate the way it looks when i click to album; it's too ugly in comparison to the last versions. I wish I hadn't updated!
Posted by Celia on October 21, 2014 at 9:50 AM (CDT)
An Easy Guide To Setting Up + Using Apple Pay In iOS 8.1
can apple pay and passbook can be used if my iphone is set on a different country?
Posted by danny on October 21, 2014 at 2:21 AM (CDT)
An Easy Guide To Setting Up + Using Apple Pay In iOS 8.1
It isn't Apple Pay that brick and mortar stores don't yet support, it's NFC payments themselves. Apple Pay in a retail store setting is a regular NFC payment. Any store with payment terminals displaying the NFC payment logo will work with an Apple Pay enabled device…
Posted by Ben on October 20, 2014 at 4:49 PM (CDT)
What's New in iTunes 12
I've been using iTunes since it was introduced and I've never had much difficulty adjusting to the new versions. I have to say that this version is the best yet; I just can't stop playing with it.
I love the new 'Recently Added' field in the Album and Artist windows. I often had trouble remembering the latest CDs I had downloaded, so, despite wanting to find an album, I often used the songs window just so that I could use the 'Date Added' column.
Maybe this was a feature that needed to be selected which I overlooked in previous versions, as I'm surprised it wasn't mentioned in the article.
A couple of niggles I still have: When I search for an artist in Album view I'd like to be able to filter the result to just see albums by that artist, excluding other people's albums and compilations they may be on, and albums by artists who have covered their songs, just like you can in Artist view.
And it still annoys me that the Search field doesn't retain my search when I move between My Music and the Store.
But these are minor issues I can live with; overall IMO iTunes 12 is a job well done.
Posted by Stephen on October 20, 2014 at 5:14 AM (CDT)
What's New in iTunes 12
Can anyone please tell me how to get back the fields of Grouping and Episode ID in iTunes??? I can't get to these metadata fields anymore and I just added new TV series content to my media library. Its annoying because my smart playlist goes by grouping and sort by Episode ID.
Posted by Kyle Wong on October 19, 2014 at 10:40 PM (CDT)
What's New in iTunes 12
@ #4 - There's an app called MetaX that, while not necessarily the best or prettiest thing out there, can edit every field iTunes can/will display (even theatrical ratings) and will also embed poster art into the video file's metadata. It's free.
#5 - While I agree that having a separate app for iTMS/App Store (with integration for Mac App Store) would be great, I like the fact that iTunes does it all. It's a media server for the Apple TVs that I own, it's how I play back movies, TV, music, podcasts, and everything else on my Mac both locally and in the cloud, and it helps me manage my massive collection of music and movies (at least 400GiB of music, and 3x that in movies).
@ Nick Guy - the sidebar is still there, kinda; it's buried in the "Playlists" option. However, iDevices don't show up over there anymore. Being that I'm a long-time iTunes user (version 2 on a PowerMac 8500), I actually like the changes made. I'll be giving it a shot on my Windows 7 box soon, hoping Apple cleaned up the code base.
Posted by Bill on October 19, 2014 at 5:04 AM (CDT)
What's New in iTunes 12
wow best
Posted by getahun on October 18, 2014 at 4:46 AM (CDT)
What's New in iTunes 12
I like the way it looks.
One minor nit - the Account Name in the control bar displays my legal name instead of my nickname - it shows William instead of Will.
I really appreciate that the album covers now no longer have fuzzy /cloudy edges. That was an insult to the cover art designers.
TV Shows should still be changed in name to Series, since many series, such as web series, are not television shows except in an abstract sense.
Posted by Will on October 17, 2014 at 9:34 AM (CDT)
Ten Things You Didn't Know About iPad Air 2 + iPad mini 3
Apple has always been known for introducing products with out-of-the-ordinary designs and innovative features that have never failed to take the consumer market by storm and one bets example is the iPad Air.
Posted by underseaglider on October 16, 2014 at 8:01 PM (CDT)
Ten Things You Didn't Know About iPad Air 2 + iPad mini 3
Funny list of descriptive words, JB
Nice found poem!
Posted by choicweb on October 16, 2014 at 3:47 PM (CDT)
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Today's fun video: For those missing the debates
President Obama and Sen. John McCain must be pining for the debates from last fall.
Obama gave McCain the first question at the economic summit. What are you going to do about those pricey helicopters, McCain asked.
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