text:
Has anyone modified their TS-E so that both tilt and shift occur on the same axis? Instructions I found seem simple enough, but the four screws that I need to remove are very tight and I didn't want to apply too much force with my jewelers' screwdriver set for fear of leaving marks or worse, striping the screws. Any success stories by TS-E owners here?
The Canon Thread - Page 181
Head-Fi's Best Sellers
- "Amazing soundstage, extremely comfortable, Outstanding sound quality""Natty, Removable 4 Conductor Cable."
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Hmm was wondering what you were talking about then i realised only the newer 24 and 17 allow you to tilt and shift on independent axis' . Never heard of anyone I know who did this mod :\
- 3,672 Posts. Joined 9/2011
- Location: Chicago, IL
- Select All Posts By This User
You shouldn't need to. There is a release so you can rotate the shift axis. Unless I'm misunderstanding what you are trying to do.
edit - ah, that release is on the 24 TS-E II
Edited by liamstrain - 1/1/15 at 9:46am
Well, I guess somebody has to post about the new Canon 5Ds and 5Ds R 50 MP cameras. Not too excited myself
- 159 Posts. Joined 7/2012
- Select All Posts By This User
Edited by jay-w - 2/10/15 at 9:53pm
New Adobe Camera RAW 9.0 now features HDR and Panorama right in ACR. Fantastic!
Downloaded it, and bummer! The HDR and Panorama tools only work for PS CC (subscription) not PS CS (me). Adobe sure knows how to rub it in to those who refuse to be slave to their subscription model
Edited by Jon L - 4/26/15 at 8:52pm
Haven't been here for a while and it looks like I didn't miss much either.
So anyone upgraded to the 5Ds or sr yet? Personally I decided to wait it out for now, as even processing 36MP is already quite slow on my dinosaur of a machine so 50MP is going to aggravate the situation even more. Besides, the biggest I go is 13x19" so I won't benefit from the extra MP... for now.
Now the rumours of a new 35L... that would pique my interest more. :-)
Personally, I will not buy another Canon body until there is fundamental improvement in the Canon sensor fabrication process, i.e. move away from the ancient 0.50µm fab process (which only Canon still uses) and/or improve the read-noise by moving the off-chip ADC to on-chip like all the other companies.
There's still hope for Canon lens-lovers like myself, since the new Sony A7r II has FAR faster AF speed with adapted Canon lenses than Mk I.
Edited by Jon L - 7/10/15 at 12:00pm
The A7r II certainly looks tempting for its AF capabilities, BSI sensor and improved metal mount... can't wait for my regular shop here to bring them in so that I can play around with it and then tell myself I don't really need yet-another-camera, lol.
- 350 Posts. Joined 12/2007
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Edited by techfreakazoid - 9/17/15 at 8:25pm
- 178 Posts. Joined 8/2013
- Location: Twin Cities, MN
- Select All Posts By This User
I just bought some new (to me) glass. I currently have a 7D MkII and just got a 24-70 F2.8L and a 70-200 F2.8L both used and in great condition. Got to play around with them over the weekend in what conditions most people would hate. High Speed and indoors. I shot with a custom profile that locked the shutter speed to 1/500 or faster and the aperture at f4 or faster and auto iso. Most shot at 1/500 f2.8 and iso 1600 to 6000. Just quickly going through them here are a few from the weekend.
Edited by Oklahoma - 11/23/15 at 8:04pm
- 7,289 Posts. Joined 12/2003
- Location: Chicago
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Head-Fi's Best Sellers
- "Amazing soundstage, extremely comfortable, Outstanding sound quality""Natty, Removable 4 Conductor Cable."
- "Soundstage, accuracy , tonal balance, slight fun factor, build quality""World class sound and comfort from Beyer"
- "Good across the frequency range, Live Sounding, Full ""Balanced, Decent Bass Body, Not much Plastic"


text:
Lead Faculty/Assistant Professor, Business and Management
Leeds, Alabama
Project Management Professional. Strategy Consultant. Organizational Improvement Specialist. Family man.
Dr. Volz has been in various roles in business over the past 25 years. He became a fulltime CTU faculty member as a Lead Instructor – Project Management in July 2013. Prior to this position, Dr. Volz was an Assistant Adjunct Professor at CTU while working fulltime as a Senior Strategy Consultant with Blue Cross and Blue Shield of Alabama. Positions held by Dr. Volz over the past several years include Corporate Manager of Quality for an industrial parts distributor, Marketing Director for a home caregiving organization, and income tax professional. Dr. Volz served in the Florida Army National Guard and was an examiner for the Alabama Quality Award program.
Recently, Dr. Volz was elected for a second two-year term as the Vice President of Education for the Birmingham chapter of the Project Management Institute. Dr. Volz holds the following certifications: Project Management Professional (PMP®) through the Project Management Institute; Certified Manager of Quality/Organizational Excellence (CMQ/OE) through the American Society for Quality; Balanced Scorecard Professional (BSP) through the Balanced Scorecard Institute; and Senior Professional in Human Resources (SPHR) through the HR Certification Institute.
Business and Management, Project Management
Copyright © 2016 Colorado Technical University (CTU). All rights reserved. No information may be duplicated without CTU's permission. The CTU logo is a registered trademark of Career Education Corporation. CTU cannot guarantee employment or salary. Not all programs are available to residents of all states. Programs vary by location and modality; see catalog for details. Financial aid is available for those who qualify. See the Accreditation & Licensure section for information on the agencies that approve and regulate the school's programs, including relevant complaint procedures here. Find employment rates, financial obligations and other disclosures below.

subset: commoncrawl


text:
10001 W. Bluemound Rd.
Milwaukee, WI 53226
(414) 771-5500
The Milwaukee County Zoo hosts more than 20 special events each year including celebrations at Easter, Halloween and the holiday season.
Open 365 days a year, the Zoo is not be be missed, it's the wildest place in town!
LUNG FORCE Walk
Welcome to LUNG FORCE Walk - Milwaukee, WI Join us as we raise awareness and funds to fight against lung cancer and for lung health. Together, we are a FORCE to be reckoned with. Did you know? •Lung cancer is the #1 cancer killer in America, and most people aren't aware. •Anyone can get it — if you have lungs, you can get lung cancer, and it's on the rise in women. •More than 33 million Americans suffer from asthma, COPD (which includes emphysema and chronic bronchitis), and other lung diseases. By joining our LUNG FORCE Walk and raising funds, you can help make a difference in lives that desperately need it. Register today! Now is the time to raise our voices against lung cancer—and for lung health. With your participation and help, our LUNG FORCE Walk will make a difference in lives that desperately need it. Register today, because now is the time to raise our voices against lung cancer—and for lung health.
Recent articles about Milwaukee County Zoo
Zoological Society of Milwaukee announces new president & CEOBy Press Release - July 11, 2016
The Zoological Society of Milwaukee is excited to announce its new president and … Read more...
D'awww! Meet Zola the Zoo's new baby giraffeBy Matt Mueller - May 26, 2016
Get ready for an overload of adorable, as the Milwaukee County Zoo introduced … Read more...
Kohl's Wild Theater for kids set to open sixth season at the ZooBy Press Release - May 12, 2016
Kohl's Wild Theater performing arts group at the Milwaukee County Zoo is set to … Read more...
Jabari goes to the Zoo: A story of friendship between Parker and a turtleBy Jimmy Carlton - Dec. 18, 2015
Bucks forward Jabari Parker loves animals and one in particular at the Milwaukee … Read more...
A free week of admission at the ZooBy Jeff Sherman - Dec. 11, 2015
From Saturday, Dec. 26 through Thursday, Dec. 31, the Milwaukee County Zoo is … Read more...


text:
The wonder of Greenpeace's protests at the Belgian Grand Prix against title sponsor Shell and the oil company's exploration activities was not the planning or nature of the high-profile stunts, but simply the fact that it has taken six decades for such a body to attack what is hardly an eco-friendly pastime. Even then it was not the event itself that was targeted, but its commercial partner.
Whether or not Greenpeace actually achieved its aim of embarrassing Shell by bringing the plight of Arctic life to the notice of the sport's hundreds of millions of followers is utterly debatable, for the most viewers saw was a slight hiccup during the podium ceremony, when two banners popped up momentarily before being hurriedly taken down by Formula One Management personnel.
Had the environmental body undertaken diligent research into its targeted activity it would soon have realised that FOM's vertical integration enables it to control every aspect of a grand prix, including broadcast rights and Formula 1 copyright.
Get back on track. Join today for unlimited access to all Autosport news and features.
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South African-born Dieter trained as industrial engineer before holding down a variety of senior motor industry marketing and manufacturing positions. At the age of 40 he decided to follow his passion, and became the first and only South African journalist to cover Formula 1 regularly. Dieter joined AtlasF1 at the beginning of 2004 – a year prior to its merger with Autosport – and his regular column offers an intriguing analysis of F1's politicking and commercial chicanery. Although now also proudly Belgian, he gives his domicile as "Wherever F1 duplicity lurks".@RacingLines More features by Dieter Rencken


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While we normally focus on the technology, to have a holistic understanding of the industry it's necessary to see the business side as well. While ARM has been an independent company for some time now, today Softbank has leveraged the fall in the value of the British Pound to buy ARM Holdings plc, the company responsible for the ARM ISA, ARM Cortex CPUs and MCUs, Mali GPUs, and numerous other IP blocks that are often used in SoCs today. If you've followed our coverage, this isn't really a surprise, but Softbank is primarily a telecom and internet-centric company with relatively little focus on CMOS chip design. ARM is valued at 11.89 GBP per share, so to be bought out at 17 GBP per share is...
Qualcomm Announces Major Workforce Restructuring With Q3 FY 2015 Results
At one point, it seemed like Qualcomm would become the ARM equivalent to Intel in the x86 space. Their Snapdragon processors, equipped with industry leading cellular technology, powered a...36 by Brett Howse on 7/22/2015
European Union Opens Up Antitrust Investigation Into Qualcomm
Word comes out of Europe this morning that the European Union's executive body, the European Commission, will be opening up an anti-trust investigation into Qualcomm. The Commission has investigated Qualcomm...22 by Ryan Smith on 7/16/2015
Comparing Snapdragon 810 v2 and v2.1: More Memory Bandwidth, Higher Clocks
Around a few weeks before the launch of the Xiaomi Mi Note Pro, I was digging through kernel source to understand Snapdragon 810 and some other Qualcomm SoCs. We...84 by Joshua Ho on 6/18/2015
MediaTek announces Helio P10 Mainstream SoC
MediaTek started promoting its new Helio branding for SoCs back at MWC this year, and we had the please to cover the the new Helio X20 announcement just a...9 by Andrei Frumusanu on 6/1/2015
Spot the CPU: Russian Baikal-T1 SoC Goes MIPS
If you keep your ear to the ground with the technology press, you can't help but notice a few news stories hitting the ground when it comes to Russia...26 by Ian Cutress on 5/27/2015
AMD's Carrizo-L APUs Unveiled: 12-25W Quad Core Puma+
One of the important press releases that came out as a result of the AMD Financial Analyst Day has been some insights into how AMD is approaching the Carrizo...50 by Ian Cutress on 5/12/2015
Qualcomm Reports FY 2015 Q2 Results: Strong Q2 But Lower Forecast For 2015
Qualcomm released their Q2 financial results today, and they had another strong quarter. Revenues increased 8% from Q2 2014, coming in at $6.9 billion. On a GAAP basis, operating...9 by Brett Howse on 4/22/2015
Imagination Launches New Low Power Wireless IP: Ensigma Whisper
Today Imagination is launching a new set of licensable wireless intellectual property (IP) called 'Ensigma Whisper' to complement its portfolio of other SoC IPs. This announcement gives Imagination a...9 by Stephen Barrett on 4/15/2015
Braswell: MSI Launches Three Mini-ITX ECO Motherboards
The launch of Braswell, to replace Bay Trail-D, is going to slowly emerge over the next few months. We reported on the initial launch of SKUs as leaked, but...17 by Ian Cutress on 4/8/2015
Intel Braswell Details Quietly Launched: Cherry Trail and Airmont on 14nm
The 14nm tri-gate for process from Intel has currently been seen in both Core M (Broadwell-Y) and Broadwell-U, with some discussions at Mobile World Congress regarding Atom x5 and...30 by Ian Cutress on 3/31/2015
GIGABYTE Server Releases ARM Solutions using AppliedMicro and Annapurna Labs SoCs
As Johan points out in his deep dive of ARM in the server market, given a focused strategy new ARM solutions can offer the potential to disrupt some very...16 by Ian Cutress on 3/24/2015
HSA Foundation Launches 'HSA 1.0 Final' – Architecture, Programmers Reference and Runtime Specifications
Heterogeneous compute has been on the tip of the tongue for many involved in integrating compute platforms, and despite talk and demos regarding hardware conforming to HSA provisional specifications...26 by Ian Cutress on 3/16/2015
Intel Xeon D Launched: 14nm Broadwell SoC for Enterprise
It is very rare for Intel to come out and announce a new integrated platform. Today this comes in the form of Xeon D, best described as the meeting...38 by Ian Cutress on 3/9/2015
MediaTek at MWC 2015: A72 In Silicon, Multi-Standard Wireless Charging & More
As part of our MWC coverage we had the pleasure to have a guided tour through MediaTek's booth to see what kind of new technologies the company has in...34 by Andrei Frumusanu on 3/8/2015
NVIDIA GDC 2015 Liveblog37 by Ryan Smith on 3/3/2015
Intel at MWC 2015: SoFIA, Rockchip, Low Cost Integrated LTE, Atom Renaming and 14nm Cherry Trail
After day zero at Mobile World Congress already boasting some impressive releases, Intel tackles their platform on day one on several different fronts. As part of a pre-briefing, we...37 by Ian Cutress on 3/2/2015
Qualcomm Announces Snapdragon 820 and Zeroth Platform
Today, Qualcomm is announcing the new Zeroth Platform, which is enabled by the Snapdragon 820 SoC. While Qualcomm is avoiding any real disclosure of the SoC at this point, we...36 by Joshua Ho on 3/2/2015
Qualcomm Announces Snapdragon Sense ID Fingerprint Scanning
In addition to a new SoC, Qualcomm is announcing a new fingerprint sensing technology for Snapdragon-based devices. While most fingerprint sensors currently use high-resolution capacitive sensors, Qualcomm's Snapdragon Sense ID...7 by Joshua Ho on 3/2/2015
Imagination Announces PowerVR G6020 GPU & PowerVR Series 5 Video Encoder
With Mobile World Congress 2015 now in full swing, Imagination Technologies is taking to the show today to announce a couple of new additions to the PowerVR family of...2 by Ryan Smith on 3/2/2015
Samsung Announces the Galaxy S 6 and S 6 Edge
In recent times, Samsung has seen the erosion of their dominance in the Android ecosystem. The reasons for why this is are many, but at least some of the...206 by Joshua Ho on 3/1/2015


text:
Most recent volume
Volume . Microelectronics and SocietyPublished: 26th February 1982 Editors: G. Friedrichs A. Schaff
Through automation and miniaturisation, microelectronics has vast potential for thrusting society into a new phase. It promises to revolutionise the information handling aspects of our lives. But to gain maximum benefit from this breakthrough, microelectronics must be harnessed to society's needs. To help this process a multidisciplinary group of authors has prepared a report to the Club of Rome on the likely impact of microelectronics on our futures


text:
Crafted from the softest fabric and styled with high fashion oomph, this brassiere from bw!tch contours your every curve and shapes to give you a great look in your body-hugging outfits. Now that's something worth investing in!
Pink padded brassiere in stretchy fabric, has lace trims above the cups with gathers and crystal embellishments on the centre. Adjustable, elasticated shoulder straps. Has underwiring
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text:
Job Details
Position Information
|We are a nationally known wealth management firm in Northern New Jersey seeking an Analyst to join our organization. We are
interested in you if you are a recent graduate of a CFP Board registered financial planning program, are looking for an entry
level position, want to learn the business and our company from the ground up, do not want to market and cold call for clients
but do want to be involved with making a direct impact on clients' lives, and work your way up our advisory career ladder.
Candidates that fit into our firm and culture will desire to be in a large wealth management RIA environment, have a true passion
for financial planning as their career calling, and are committed to a fulfilling work/life balance.
We specialize in wealth management using a customized approach for high net worth individuals, corporate executives, small
business owners, and multinational corporations. We are currently seeking a dedicated team player who is eager to learn and
contribute to our company. Our Analyst position requires a bright, hard working, goal-oriented, self-motivated, passionate,
personable, and professional individual.
Position Overview
This is a professional position that will support Financial Advisors and Wealth Managers directly in servicing the existing and
potential clients. You will be expected to perform various tasks including portfolio reviews and preparing financial projections
using Excel spreadsheets and MoneyGuidePro financial planning software. You must have the ability to utilize critical thinking
skills, work within a team, and anticipate firm needs and client questions. Qualified candidates will be detail oriented,
structured and have a high degree of follow through.
Initial Key Areas of Responsibilities:
• Preparing financial analyses for clients, including retirement analysis, estate planning analysis, education funding
analysis, stock options analysis, and risk management needs analysis
• All aspects of pre-client meeting activities such as preparation of meeting agendas, client paperwork, Investment Policy
statements, asset allocations as well as post-client meeting tasks such as develop meeting notes, perform financial situation
analyses, and coordinate planning implementation with outside professionals if necessary
• Continuously monitor clients' financial situations with detail and accuracy
• Be able to keep up and learn things quickly in a fast paced environment and effectively manage regular changing of
Key Qualifications:
• B.S. degree from accredited four year university preferably in financial planning, business, finance, economics, etc.
• CFP® certification or attainment within 1-2 years after joining firm
• Series 65 or attainment within 90 days after joining firm, if required
• Strong financial and analytical skills
• Strong verbal and written communication skills
• Strong persuasive and interpersonal skills
• Basic understanding of investment and financial planning strategies for high net worth clients
• Ability to identify, meet and follow through with client needs and requirements
• Must be a self-starter, problem solver and a goal-oriented team player with a 'no job is beneath me' attitude
• Organized, with a strong attention to detail
• Able to perform multiple tasks efficiently
• Show confidence, yet in a humble manner, when dealing with clients, firm Financial Advisors and Wealth Managers
• Superior knowledge of Microsoft Excel, Word and PowerPoint
• Competitive salary with incentives based on firm client retention, revenue, client and profit growth
• Company subsidized health, dental and vision insurance
• 401k plan
• Educational reimbursement (continued education, conference attendance, etc.)
• Paid licensing dues
• Mentorship and Learning Opportunities
Hiring Organization
|New Planner Recruiting, LLC
|Our firm specializes in placing students (undergraduate/graduate/career changer) enrolled in CFP Board registered programs,
candidates for CFP® certification, and CFP® practitioners for professional positions (usually 0-5 years experience) that will
develop into the lead client planner role within financial planning firms nationwide. Our mission is to help financial planning
business owners leverage their time by finding, selecting, and securing quality talent to help them grow, and to ensure that
quality new financial planners are able to find employment that fits their unique talents and skills, in pursuit of securing
mutual success for the business owner and new planner.
|Finance / Banking - Invesstment Banking
|Web site
Hiring Contact Information
|Mr. Adam Ley
|1860 Barnett Shoals Drive
Suite 103 PMB 445
Athens GA 30605


text:
Port News
Linea Peninsular has added a weekly container service to Port Tampa Bay.
Container throughput at the world's busiest container terminal operator, Hutchison Port Holdings, fell in the first half.
The Port of Houston's overall container volume passed 1 million 20-foot-equivalent units for the first half of the year.
Rotterdam's lead over Antwerp as Europe's largest container port continues to narrow.
Dockworker arrests are only the latest intrigue at South America's busiest container port.
DP World expects its modest growth in the first half of the year to speed up.
Plans for the second of six planned inland ports are moving ahead in Georgia, part of an effort to expand the port of Savannah's intermodal reach into the fast-growing U.S. Southeast market.
The immediate roadblocks, stalemates and impasses the group confronted at the July 15 highlight the deep divisions among the members of the congressional working group and the challenges they'll face in the months ahead.
Angry Mexican teachers are blockading some of the country's railways, leaving thousands of containers stranded.
The Brexit will slow U.K. containerized trade in the short term.


text:
Offers & Promotions
- Malta with Thomson
An island holiday in the Mediterranean with lots to offer...
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Latest News
- First Spitfire Passenger Flights from Exeter
Fly in the iconic aircraft over Devon
- Flybe Top for On Time Performance
Exeter headquartered airline heads CAA Punctuality Statistics
- All Flybe winter flights now on sale
Bookings open for winter including Alicante and Malaga
- News and Features from Flybe
The Flybe in-flight FLIGHT TIME magazine
- Updates and Twitter Tweets
Stay in touch with email Newsletters and Twitter
Archived News
For more information... click on the headline
More Austrian Tourists
Thursday 01 July 2010
Exeter Airport will welcome another five hundred and fifty Austrian tourists later this year following a deal with travel company Raiffeisen Reisen to operate three Lauda Air flights from Vienna in September and October.
This year's boost to tourism follows the success of the 2009 initiative when five hundred travellers from Austria, with an interested in the region's landscapes and historic buildings which were featured in TV programmes based on the books of Rosamund Pilcher, enjoyed seven day special escorted holidays in Devon and Cornwall.
Jamie Christon, Managing Director at Exeter Airport said: "The adapted Rosamund Pilcher romances draw an average 6 million viewers every week and the writer has sold 60 million books, so the potential to further develop of this inbound tourism market is enormous."
The Austrian tourists, who will arrive on 22 and 29 September and 6 October, will have the opportunity to enjoy the scenery which inspired the Cornish writer's stories and see the venues used by the television crew from the Munich-based FFP New Media company.
Rosie Bates General Manager, Visit Devon said: "The European television exposure for the area has brought about a flurry of new visitor interest and the announcement of year's flights is fantastic news for the South West.
Also see:
Airport History
Airport War Years


text:
Sometimes it's stinky, sometimes it's oozy, but it's your body! Come to this interesting program for facts, stories, experiments, and trivia about all things disgusting. This program is not for those with a high "Ewww!" factor! Classes are open to all tweens and teens and every program is free. See you there!
Coastal Region branch
Tuesday, June 10, 2:00 - 3:30 pm
From our Community Partners Blog
One Courthouse SquareInverness, Florida Back by popular demand, the Dusty Road Rangers on Saturday, July 16 at 7pm at The Old Courthouse Heritage Museum. Tickets are... Read more
From our Community Partners Blog
It's time again for another of Citrus County Parks & Recreations Movie in the Park Events. This months movie will be "Zootopia" Rated PG. Pre-Show Activities are from 6:30... Read more
From our Community Partners Blog
GulfCoast North Area Health Education Center is partnering with Citrus County Library System to provide a FREE 2-hour tobacco dependence seminar. Anyone interested in quitting... Read more
From our Community Partners Blog
If you aren't familiar with Medicare or the other available resources, or if you just want to brush up on what you already know, SHINE... Read more
From our Community Partners Blog
The Friends of the Crystal River State Parks, Inc., in partnership with the Florida Park Service, the Florida Coastal Office (FCO) and the Florida Public... Read more
The Citrus County Library System will promote the pursuit of knowledge and deliver quality education to the community, embracing the power of information, imagination, and ideas.


text:
San Juan, Argentina News
Local news for San Juan, Argentina continually updated from thousands of sources on the web.
El Nino sees Argentine harvest drop 25%
Tuesday Jul 5 | The Drinks Business | Comment?
Argentinian podium sweep in San Luis stage 5
Jan 22, 2016 | Velonews | Comment?
San Juan, Argentina news is powered by NewsRank™
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text:
Engine Mechanical problem
2006 Cadillac CTS 6 cyl Two Wheel Drive Automatic 96000 miles
I want to change the spark plugs in my 2006 Cadillac CTS with the 3.6L engine. How do you do it and do you have to remove the engine cover?
Tuesday, October 12th, 2010 AT 3:47 PM


text:
EventsYou — and your family — are invited to experience life at the University of Dayton during our admission events.
A variety of events are offered throughout the year, so check back often to see what's happening and sign up for events. We look forward to seeing you on campus!
College Night
Learn More
Learn More


text:
When the going gets tough. Why Get a Loan From Us?
Advance America
Advance America
Sundrips "When"
Knowing that Event Cloak is Nick Maturo, the ½ of Canadian ambient unit Sundrips might led you to believe that "Reprogramming" is yet another cassette of soothing and relaxed sounds with a droney edge. It's okay to believe that, many side-projects of better known bands fall into the trap called "sounding the same as original band, only simpler", especially in the whole cassette drone scene. So don't get too scared when you're greeted with harsh, glitchy intro with fragmented, nearly tormented vocal transmissions reminiscent of Morton Subotnick on amphetamines. "Reprogramming" sees Maturo maturing, and expanding beyond the lazy, hazy confines of New New Age muzak.
Sure, the sounds on the cassette will often wander into the well worn territories of sequencer-heavy prog electronix, but always with a noisy, atonal twist, experimenting with Reich-like fragmentation and attempts at applying minimalist methods at the analog synthesizer revival. Fragments of some tracks might seem forced and needlessly stretched at times, but then again, most minimalism can sound forced and stretched to the less patient listeners. Electronic madness bobs up and down, switching from fluorescent noisy escapades to almost endless walls of purified electronic drone. There will be also times when Event Cloak will totally surprise, like the cut-up sound collages and plunderphonic bliss on some tracks, mixing mauled, distorted speech samples with fragments of someone else's songs devoid of any context, creating a chaotic narrative in an uknown language based on English. Microscopic pieces of movie quotes, news broadcasts and (probably) speech samples recorded by Maturo himself blend into a microcosmos in the vein of Akufen, sans the microhouse beats.
"Reprogramming", as an album, shows great potential. At approximately 54 minutes, it is the collection of ideas from Nick Maturo, who might want to distance himself from the tired ambience of Sundrips (or maybe not), and expand his musical horizons into the previously unheard areas. Godspeed to him, I say. Guessing from his individual ideas of how to sculpt sounds, he has a bright future in front of him. Just don't be afraid to go all the way into other genres and directions, Nick. I wish you the best.
Buy the tape from Tranquility Tapes! Last copies remaining!
sundrips "daylighting"
Two wonderful sets from two wonderful friends of They Live We Sleep. Recorded on December 27th 2010, at Casa del Popolo in Montreal. That night we celebrated the release of They Live We Sleep's first DVD-R with a screening, some beers, some jokes, and some drones.
First up, Sundrips. One of their oddest and best sets to date, but each performance is always better than the last with these two so what the hell do I know? Heavy noise as an introduction, twilight drone as a conclusion, truly one of a kind. For the full experience, watch Joe Dante's contribution to Twilight Zone: The Movie.
Then, Hobo Cubes. Rumbling nightbus synth drones, bordering on truly filthy beats. I've never seen or heard anything like it. He wore a silly hat. For the full experience, watch Class of 1984 on 0.6x speed, starting with the gang fight under the bridge.
Thanks to Hobo Cubes for recording the sets, thanks to Nick, Ryan, and Frank for showing up and pulling off some truly amazing sets, and thanks to the 30 people who showed up!
Sundrips - Apocalypse
American Express®


text:
Climbing out on our way to Moscow Sheremetyevo. Flight SU2105, seat 18A.
"City of Tokyo" slamming it down in crosswind conditions on runway 18R.
Operating a flight from Preveza on behalf of Arkefly.
Flight B2-872 from Geneva to Minsk.
Nice morning conditions as we are climbing out from Chisinau on our way to Bucharest. Flight RO208, seat 4D.


text:
The best time to register for DrupalCon Dublin is now. Earlybird discounts end July 29.
Changes since 8.x-3.0-alpha25:
Changes since 8.x-3.0-alpha24:
Changes since 8.x-3.0-alpha23:
This is an incremental release of the ctools suite to help support panels and panelizer.
Major change between alpha22 is the addition of the ctools_block module which allows adding fields as blocks.
Changes since 8.x-3.0-alpha21:
Changes since 8.x-3.0-alpha20:
This is an incremental bugfix release for ctools, particularly for newer versions of php 5. (5.4+)
ctools is now in bug and security only maintenance mode. Any future feature requests should be made in the 7.x or preferably, the 8.x branch.
Changes since 6.x-1.14:
Changes since 8.x-3.0-alpha19:
Changes since 8.x-3.0-alpha18:
Syncing release with Page Manager and Panels
Initial tagged release of ctools 8.x-3.x. Named to match corresponding page_manager and panels releases for increased clarity.
Follow up release to ctools 1.8. This includes some additional features, not bug fixes. For the Security and bug fixes, please refer to the 1.8 release of ctools.
Changes since ctools 1.8
See Ctools - Critical - Multiple Vulnerabilities - SA-CONTRIB-2015-141.
This is mainly a bug and security release for ctools 7.x. If you want some of the new features, please look at ctools 1.9.
Changes since ctools-1.7
This is an incremental security and bugfix release for ctools.
Looking to fix future D6 CTools issues? Find japerry or merlinofchaos in #drupal-scotch, #drupal-contribute, or #drupal-panels -- and become a maintainer for D6 CTools.
Changes since 6.x-1.13:
This is the last major bug and new feature release for ctools 6.x-1.x. From here on out, ctools 6.x is only maintained for security releases, until the d6 maintenance window closes.
Changes since 6.x-1.12:
This is an empty 3.x branch for ctools. 1.x is only for D6 and D7, 2.x is orphaned due to versioning conflicts with 2.x API in D7 ctools.
This is an incremental release for ctools 6.x-1.x. ctools 6.x is only maintained for security releases, and contains the following issue:
SA-CONTRIB-2015-079 - Chaos tool suite (ctools) - Multiple vulnerabilities
If you haven't already we suggest updating to Drupal 7 to get the most out of new ctools features!
This release of ctools is primarily a bug fix, and contains two security issues:
Other Changes since 2015-01-29 (ctools 1.6):
This release of cTools includes -all- of the 2014 RTBC issues from the 7.x release. There is a mix of new features and bug fixes.
Thanks everyone for helping get this release out, especially during the SprintWeekend2015!
Changes since 2014-11-19:
This release of cTools includes most of the RTBC issues from the 7.x release. There is a mix of new features and bug fixes.
Because of the amount of RTBC issues, we're doing a RC1 release first to make sure there are no regressions. While all the patches passed tests and a smoke test, there could be issues and we want to make sure everything is stable before rolling a 1.6 release.
After a 2 to 3 week test, we will roll a full 1.6 release. If you want to help out, ping japerry in irc.freenode.net #drupal-panels or #drupal-contribute!
Drupal is a registered trademark of Dries Buytaert.


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Handled chopping boards are inspired by the v&a's silver galleries. The sustainably manufactured bamboo allows for this intricate design and strength. The handles based on traditional silverware give a sense of luxury and an additional function when handling the boards. This collection is available in five styles, with the angles fit together to make a set.
Material: Staved Bamboo 20mmColours: Natural Caramel, there will always be slight variations in colour with natural materials.
A collection of multi functional design objects that are inspired by Ernö Goldfingers modernist home in Hampstead Heath. They pay homage to the renowned architects ethos, his Modernist and Brutalist architecture and his private art and object collections in the house. This project was born out of a design residency with The National Trust and Bow Arts from February to October 2015.
Candle Holder 'Balfron'
Sand Cast Iron, Concrete based jesmonite.
These stack-able candle holders are like mini brutalist water towers. The modernist symbols of circles and crosses are also influenced by the artwork and found objects within the house. The iron and concrete parts can be used either way up, stacked on top of each other or separately to hold three different sizes of candle.
Inspired by Victoriana and brought right up to date with reduced geometric lines, faceted forms and a monochrome palette offset with stripped-back wood. This collection has a strong contemporary aesthetic and a simply decadent feel. The mirrors come in five different styles, their names pay homage to old English gentlemen's names with little references to Londons East end and of course Victoria and Albert.
Materials: Mirrored Acrylic, Birch PlyColours: All mirrors vailable in Black Stain, White Stain & Natural
Buy Deconstructed Mirrors here
Alloy pays homage to traditional silversmithing, the coaster inspired by the Scottish Quaich, a cup symbolic of friendship which would be shared in the celebration of a guest's arrival or departure; it was also traditionally used for whisky and brandy. Alloy's combination of a faceted silhouettes its visual and physical lightness and strength of material give this piece its modern look and intriguing nature. Material: 1mm Powder Coated SteelColours: Comes as a set in any combination of Black & White.
Buy Alloy Trays here.
Jewellery Box 'Ursula'
Hand pierced Copper, Turned Oak .
The jewellery box when closed creates intrigue to its function and contents. The cut in the side and the hole in the copper allows you to instinctively want to interact with it and understand its function. When the lid is removed it can be held upright by the cut in the side of the bowl to create a perfectly angled mirror. Oak is used throughout the house, and though I would have liked to use brass as the mirror, copper felt more natural as traditionally this is the original material used for mirrors.
Clean lines and silhouetted designs give Ara mirrors their contemporary look and timeless feel. They are inspired by over one hundred years of mirrors and hand mirror styles. Made from acrylic they are surprisingly light and are hung from a delicate brass chain. They sit beautifully on their own, in a small cluster or as the whole collection. This full collection is also stocked by Liberty.
Buy Ara Mirrors Here.
Two tone dodecagon mirrors in silver and gold acrylic are adjustable and joined by a single length of brass chain. The geometric mirrors can be displayed at many different heights and configurations and hung by one point or two. Duo has a modern aesthetic with subtle Art Deco influences. Material: MDF & Mirrored Acrylic, brass chain.Colours: Silver & Gold Mirror,
Buy Duo Mirror here.
Desk Tidy 'Ernȍ'
Sand Cast Bronze.
The tessellating desk tidy on first glance appears to be a modernist looking sculpture, the symbols of a circle within a square appears throughout the artwork in the house. However as soon as you start interacting with the pieces its function becomes evident with each configuration
Digital Soane, was a competition organised in collaboration with the Royal College of Art Sir John Soane's Museum with the support of the Jerwood Charitable Foundation. In March 2014, the bust of Sir John Soane, which sits centre stage in the Museum's Dome Area, was 3D scanned and digitally shattered. The fragmented pieces were then used as the starting point for a new object created by RCA Jewellery & Metal graduates.
Haidée's winning 'Collar' Vase dramatically contrasts between the flowing organic replica of the fragment, and the angular facades that attribute its function. The piece has retained the feeling of a fragment or a slice of the bust; this with the combination of the naturalistic white marble material will give the impression that you actually have a piece of Sir John Soane's bust on your mantelpiece. The vase has been designed to hold one large flower or a small flower arrangement, The lean of the vase assists in the arrangement. Haidée has developed two more vases for Sir John Soane's Museum. They are aptly names 'Brow' Vase and 'Drape' Vase and were developed from selected fragments and cast in Marble and granite jesmonite.
Buy Soane Vases Here
Moor is a collection of vessels that have been developed by coiling various thicknesses of rope. A four part plaster mould was then made and slip cast in porcelain, each one left with its unique imprint.
JoJo wall hooks are an elegant and functional and humerous take on the popular 1930's kitsch three flying ducks. Made from porcelain these wall hooks are incredibly strong. The hooks have been developed by slip casting porcelain using a two part mould.
Elegant and versatile, Tapa tableware allows food to be shared and enjoyed from every angle. The tessellating forms stack together to make even the most adventurous dining effortless. At every stage of the design process, attention to detail has resulted in a sculptural balance of curves and linear forms, resulting in a range that respond to each other individually and as a collection in any number of multiples.
A homage to east London architecture, significant buildings with their own personal history, recreated with function and created from birch ply and acrylic. Balfron BOX is a contemporary version of a Victorian Fern Case, inspired by Haidee's residency in the listed Brutalist Tower. After the great exhibition of 1851 Fern cases and Terrariums becameimmensely popular, Ferns and then orchids were displayed in people homes as a show of opulence. BALFRON BOX pays homage to this time and to Erno Goldfinger the architect of the iconic Building in Poplar.
BOX Factories is a collection of boxes that pay homage to the historical warehouses and wharf's of Hackney Wick on the edge of the Olympic Park. They were originally shown at Hackney Wicked Art Festival at Vittoria Wharf Studios. And then again at the Victoria & Albert Museum takeover. Each building has a unique history, from war tales of boxing gas masks to the labyrinths of artist studios that are there today. The boxes have since been featured in Elle Decoration and Homes & Gardens, and have brought about many bespoke commissions.


text:
Orlando, FLUSA
Hometown: Chicago
July 14, 2013
My friend Debbie told me about this group and I wanted to see what it was all about :)
My name is Paul50 and strive to live up to an ideal that says: "I am committed to achieve greatness. I will change the world by my actions because I am grateful for my blessings." I am a vegetarian and would love to meet people of the same ideals.
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
- Miss Florida 2017 stripped of crown days after win - US Weekly
- Lindsay Lohan steps out amid relationship drama - TMZ
- Was Taylor Swift snubbed by the VMAs? - Gossip Cop
- Rachel Platten sings "Fight Song" with lots of stars - Just Jared Jr
- Farrah Abraham sizzles in a revealing bikini - Radar
- New pics from the Clooneys' Italian summer - Lainey Gossip
- Fox News snubs major DNC moment - The Hollywood Reporter
13 April 2009 at 7:17 PM
Johnny Depp Goes Through the Roof
Posted in Johnny Depp Goes Through the Roof
About this photo set: Johnny Depp continues to shoot scenes for his new movie, The Rum Diary in Puerto Rico on Monday (April 13). Check out Johnny as he sits on the lap of his co-star… Read More Here
Photo #: 1851231
Posted to Johnny Depp
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Google speeds past Apple in the race to train mobile app devs in India
Apple can now open flagship stores in India thanks to new FDI ruling
India's security concerns are delaying Google Street View coverage
All stories in India
Uber enforces comprehensive background checks on drivers in India
A month after a passenger was allegedly raped by one of its drivers in the capital city of New Delhi, Uber has teamed up ...
Xiaomi launches 3G Mi 4 smartphone in India for $325
Half a year after its launch in China, smartphone manufacturer Xiaomi is bringing the Mi 4 to India. The device will go on ...
Uber returns to New Delhi after being banned for over a month
Uber has announced that it is resuming its cab service in the Indian capital of New Delhi, where it was banned last month ...
Twitter acquires Indian mobile platform startup ZipDial
Twitter announced today that it has agreed to acquire Bangalore, India-based mobile business and brand platform developer ...
Google Maps adds lane guidance in India
After introducing lane guidance across Europe last month, Google Maps is now bringing the feature to India. This update will ...
Rdio brings its music streaming service to India
Already available in 60 countries, Rdio has just launched in India. The streaming service offers more than 32 million songs ...
BlaBlaCar brings its ride-sharing service to India
BlaBlaCar, the city-to-city ride-sharing service which has made waves across Europe, Russia and Turkey, has arrived in India. ...
Google's Flight Search lands in India
Google's Flight Search tool is now available to Indian users, allowing them to look up air travel options around the globe ...
India lifts blocks on GitHub, Vimeo, Dailymotion and Weebly but others remain banned
The Indian government's block of websites has been lifted for gist.github, Vimeo, Dailymotion and Weebly but 28 other sites ...
GitHub, Vimeo and 30 more sites blocked in India over content from ISIS
Following an order issued by the Department of Telecom in India, ISPs have blocked 32 sites including Vimeo, Dailymotion, ...
OnePlus rival Micromax's controversial Cyanogen-powered smartphone launches in India
The battle is on: Micromax, the Indian electronics brand that got OnePlus banned from selling phones in India, has just launched ...
After Xiaomi, OnePlus faces sales ban in India
India certainly isn't making it easy for consumers to get their hands on trending smartphones. The Delhi High Court has just ...


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- We will conduct monthly maintenance on your servers. This pro-active approach to IT support catches problems before they become an issue.
- We will ensure that a strict backup process is enforced, backup logs will be checked and testing of the backup data will be conducted


text: I saw Kubuntu-Active in Synaptic, so installed it to see how it works. It got installed alright, but I can't see the cursor, I mean it is there and it shows only on the top, and when brought into the middle, the cursor vanishes. This one is for PCs, so it should work with the keyboard and the mouse. Anyway, have anyone succeeded in using Kubuntu-Active?


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text:
|Publication number
|Publication type
|Application number
|Publication date
|Mar 17, 2009
|Filing date
|Feb 13, 2008
|Priority date
|Feb 14, 2007
|Fee status
|Also published as
|Publication number
|Marja Sodervall, Maire Eloranta, Arja Kalapudas, Brian Kearton, Michael McKenzie
|Original Assignee
|Hormos Medical Ltd.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (66), Non-Patent Citations (36), Referenced by (3), Classifications (13), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims priority to U.S. Patent Provisional Patent Application No. 60/889,835 filed Feb. 14, 2007, hereby incorporated by reference.
1. Field of the Invention
This invention relates to the preparation of fispemifene using ospemifene as a starting material.
2. Description of Related Art
The publications and other materials used herein to illuminate the background of the invention, and in particular, cases to provide additional details respecting the practice, are incorporated by reference.
Ospemifene, (Z)-2-[4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol, which is one of the main metabolites of toremifene, is known as an estrogen agonist and antagonist (Kangas, Cancer Chemother. Pharmacol. (1990) 27:8-12; WO 96/07402 and WO 97/32574). Ospemifene has relatively weak estrogenic and antiestrogenic effects in the classical hormonal tests (Kangas, 1990). It has anti-osteoporosis actions and it decreases total and LDL cholesterol levels in both experimental models and in human volunteers. It also has antitumor activity in an early stage of breast cancer development in an animal breast cancer model. Ospemifene is also the first SERM (selective estrogen receptor modulator) which has been shown to have beneficial effects in climacteric syndromes in healthy women. The use of ospemifene for the treatment of certain climacteric disorders and atrophy-related diseases or disorders in postmenopausal women is disclosed in WO 02/07718 and WO 03/103649.
WO 01/36360 describes a group of SERMs, which are tissue-specific estrogens and which can be used in women in the treatment of climacteric symptoms, osteoporosis, Alzheimer's disease and/or cardiovascular diseases without the carcinogenic risk. Certain compounds can be given to men to protect them against osteoporosis, cardiovascular diseases and Alzheimer's disease without estrogenic adverse events (gynecomastia, decreased libido etc.). Of the compounds described in said patent publication, the compound (Z)-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethanol (also known under the generic name fispemifene) has shown a very interesting hormonal profile suggesting that it will be especially valuable for treating disorders in men. WO 2004/108645 and WO 2006/024689 suggest the use of fispemifene for treatment or prevention of age-related symptoms in men, such as lower urinary tract symptoms and diseases or disorders related to androgen deficiency in men.
Known methods for the syntheses of compounds like ospemifene and fispemifene include rather many steps. WO 02/090305 describes a method for the preparation of fispemifene, where, in a first step, a triphenylbutane compound with a dihydroxysubstituted butane chain is obtained. This compound is in a second step converted to a triphenylbutene where the chain is 4-chlorosubstituted. Then the desired Z-isomer is crystallized. Finally, the protecting group is removed to release the ethanol-ethoxy chain of the molecule.
Both ospemifene and fispemifene are likely to be commercialized in the near future. Thus, there is a great need for powerful methods for the preparation of these compounds in large scale. Particularly, the object of this invention is to provide a method for synthesis of fispemifene using ospemifene as starting material in only two steps, with no need to purify the intermediate.
Thus, according to one aspect, this invention concerns a method for the preparation of a compound of formula (I)
wherein a compound of formula (II)
is alkylated with an alkylating reagent of the formula Hal-CH2—COOR, wherein Hal is halogen and R is an alkyl, to give a compound of formula (III)
and the ester of formula (III) is reduced to give the compound of formula (I).
This invention is also directed to a group of novel compounds of formula (III) where R is a C1-C4-alkyl, preferably methyl, ethyl or t-butyl.
Furthermore, this invention concerns the use of compounds of formula (III) in the manufacture of fispemifene.
Fispemifene is the Z-isomer of the compound of formula (I)
The starting material, compound (II), may be prepared by methods known to those of ordinary skill in the art. The alkylating agent is Hal-CH2—COOR. The alkyl R in the alkylating reagent is preferably a C1-4-alkyl, most preferably ethyl. Examples of a C1-4-alkyl also include methyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, and t-butyl. The step of alkylating is conducted at a temperature and for a time sufficient to achieve substantial alkylation of compound (II). The halogen (Hal) in the alkylating reagent is preferably 1, Br or Cl, and most preferably Br.
The reduction of the compound (III) to compound (I) is preferably carried out by lithium aluminium hydride, although other reducing agents well known to those of ordinary skill in the art may also be used. The step of reduction is carried out at a temperature and for a time sufficient to produce substantially pure fispemifene.
The invention will be illuminated by the following non-restrictive Examples.
2-[4-(4-Chloro-1,2-diphenyl-but-1-enyl)-phenoxy]-ethanol (Compound II) (0.3 g, 0.79 mmol) was dissolved in tetrahydrofuran (5 ml) under a nitrogen atmosphere. Sodium hydride (0.058 g, 1.21 mmol) was added in THF (5 ml) to the solution and the mixture was stirred at room temperature for an hour. Then the mixture was cooled to 0� C., ethyl bromo acetate (0.4 g, 2.38 mmol) was added and the stirring was continued for 5 hours at 0-5� C. The mixture was allowed to warm up to room temperature and stirring was continued overnight. Then the reaction is quenched with water and ethyl acetate. The aqueous layer was separated and extracted with ethyl acetate. The organic phase was washed with water, dried with sodium sulphate and evaporated to dryness. The residue was used in the next reaction step without further purification.
1H NMR (200 MHz, CDCl3): 1.25 (t, 3H, CH 2 CH 3), 2.94 (t, 2H, ═CH 2CH2Cl), 3.44 (t, 2H, ═CH2 CH2 Cl), 3.85-3.90 (m, 2H, OCH 2 CH 2O CH2CO), 4.03-4.07 (m, 2H, OCH 2CH2OCH2CO), 4.18 (s, 2H, OCH2CH2OCH 2CO), 4.19 (q, 2H, CH 2CH3), 6.58 (d, 2H, aromatic proton ortho to oxygen), 6.80 (d, 2H, aromatic proton meta to oxygen), 7.1-7.43 (m, 10H, aromatic protons).
{2-[4-(4-Chloro-1,2-diphenyl-but-1-enyl)-phenoxy]-ethoxy}-acetic acid ethyl ester was dissolved in tetrahydrofuran at room temperature under nitrogen atmosphere. Lithium aluminium hydride was added to the solution in small portions until the reduction reaction was complete. The reaction was quenched with saturated aqueous ammonium chloride solution. The product was extracted into toluene, which was dried and evaporated in vacuo. The residue was purified with flash chromatography with toluene/triethyl amine (9.5:0.5) as eluent. Yield 68%.
1H NMR (200 MHz, CDCl3): 2.92 (t, 2H, ═CH 2CH2Cl), 3.42 (t, 2H, ═CH2 CH2 Cl), 3.59-3.64 (m, 2H, OCH2CH2O CH2 CH 2OH), 3.69-3.80 (m, 4H, OCH2 CH 2OCH 2 CH2OH), 3.97-4.02 (m, 2H, OCH2CH2OCH2CH2OH), 6.57 (d, 2H, aromatic proton ortho to oxygen), 6.78 (d, 2H, aromatic proton meta to oxygen), 7.1-7.43 (m, 10H, aromatic protons).
It will be appreciated that the methods of the present invention can be incorporated in the form of a variety of embodiments, only a few of which are disclosed herein. It will be apparent for one of ordinary skill in the art that other embodiments exist and do not depart from the spirit of the invention. Thus, the described embodiments are illustrative and should not be construed as restrictive.
|Cited Patent
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|Eli Lilly And Company
|Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma
|Nov 12, 1993
|Oct 4, 1994
|University Of Massachusetts Medical Center
|Use of retinioc acid to treat vaginal atrophy
|Jul 29, 1993
|Aug 29, 1995
|New York University
|Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
|May 23, 1994
|Nov 28, 1995
|Stromberg; Brent V.
|Method of treating peripheral vasoconstriction with tamoxifen citrate
|Jan 24, 1994
|Feb 13, 1996
|Orion-Yhtyma Oy
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|Aug 21, 1995
|Oct 22, 1996
|Eli Lilly And Company
|Methods of treating obesity by inhibiting physiological conditions associated with an excess of neuropeptide Y
|Sep 20, 1994
|Aug 19, 1997
|Eli Lilly And Company
|Method for inhibiting mammalian breast carcinoma with tamoxifen, and analogs thereof, and certain naphthyl compounds
|Sep 24, 1996
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|Eli Lilly And Company
|Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
|Jun 12, 1996
|Dec 2, 1997
|Hoechst Marion Roussel, Inc.
|Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis
|Oct 17, 1994
|Feb 17, 1998
|Schering Aktiengesellschaft
|Combination of progesterone antagonists and antiestrogens with partial agonistic action for hormone substitution therapy for perimenopausal and postmenopausal women
|Jul 11, 1996
|May 5, 1998
|Novo Nordisk A/S
|Atrophy of skin/mucous membrane
|Sep 6, 1995
|May 12, 1998
|Orion-Yhtyma Oy
|Triphenylethylenes for the prevention and treatment of osteoporosis
|Jul 5, 1996
|Sep 15, 1998
|Schering Aktiengesellschaft
|Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents
|Feb 17, 1995
|Oct 13, 1998
|The United States Of America As Represented By The Department Of Health And Human Services
|Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer
|May 26, 1995
|Oct 27, 1998
|Pfizer Inc.
|Use of droloxifene for the treatment of cardiovascular diseases
|May 26, 1995
|Dec 22, 1998
|Pfizer Inc.
|Use of droloxifene for the treatment of protastic disease, endometriosis and obesity
|Jun 18, 1997
|Mar 2, 1999
|Glaxo Wellcomeinc.
|Non-steroidal ligands for the estrogen receptor
|Sep 25, 1997
|Jun 15, 1999
|Orion-Yhtyma Oy
|Triphenylethylenes compositions
|Mar 4, 1997
|Mar 14, 2000
|Orion Corporation
|Serum cholesterol lowering agent
|Dec 14, 1999
|Jun 12, 2001
|Eli Lilly And Company
|Pharmaceutical formulation
|Jul 21, 2000
|Jun 12, 2001
|Hormos Medical Oy, Ltd.
|Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause
|Feb 19, 1999
|May 28, 2002
|Orion Corporation
|E-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol and pharmaceutical compositions thereof
|Jul 21, 1999
|Feb 25, 2003
|Novo Nordisk A/S
|Stable pharmaceutical formulation
|Nov 15, 2000
|Jun 10, 2003
|Hormos Medical Oy Ltd
|Triphenylalkene derivatives and their use as selective estrogen receptor modulators
|Nov 8, 2000
|Oct 14, 2003
|The University Of Tennessee Research Corporation
|Method for chemoprevention of prostate cancer
|Apr 8, 2003
|Apr 5, 2005
|Hormos Medical Oy Ltd
|Triphenylalkene derivatives and their use as selective estrogen receptor modulators
|Mar 21, 2002
|May 10, 2005
|Hormos Medical Corporation
|Method for the preparation of 2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethanol and its isomers
|Jun 6, 2002
|Jan 10, 2006
|Hormos Medical Corporation
|Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
|Mar 15, 2001
|Oct 25, 2001
|American Home Products Corporation
|Hormone replacement therapy
|Jun 5, 2003
|Dec 9, 2004
|Risto Santti
|Method for the treatment or prevention of lower urinary tract symptoms
|Feb 13, 2004
|Aug 18, 2005
|Hormos Medical Corporation
|Method for enhancing the bioavailability of ospemifene
|Feb 23, 2004
|Aug 25, 2005
|Hormos Medical Corporation
|Method for treatment or prevention of osteoporosis in individuals with high bone turnover
|Aug 8, 2002
|Sep 29, 2005
|Shuichi Furuya
|Gnrh agonist combination drugs
|Nov 6, 2006
|May 10, 2007
|Hormos Medical Ltd.
|Novel oral formulations of ospemifene
|Jan 23, 2007
|Aug 23, 2007
|Steiner Mitchell S
|Prevention and treatment of androgen-deprivation induced osteoporosis
|Feb 22, 2005
|Aug 30, 2007
|Hoekstra William J
|Substituted Quinoline Compounds For Use As Selective Estrogen Receptor Modulator
|May 20, 1983
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|Novel tri-phenyl alkane and alkene derivatives and their preparation and use
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|Apr 28, 1995
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|Leiras Oy
|Pharmaceutical compositions derived from microelmulsion-based gels, method for their preparation and new microemulsion-based gels
|Sep 6, 1995
|Aug 18, 1999
|Orion-Yhtym� Oy
|Triphenylethylenes for the prevention and treatment of osteoporosis
|Jan 5, 2001
|Aug 22, 2001
|Pfizer Products Inc.
|Use of estrogen agonists / antagonists for the treatment of sexual dysfunction
|Sep 27, 1991
|Apr 16, 1992
|Board Of Regents, The University Of Texas System
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|Mar 25, 1993
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|Mar 31, 1995
|Oct 12, 1995
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|Permanently ionic derivatives of steroid hormones and their antagonists
|Sep 6, 1995
|Mar 14, 1996
|Orion-Yhtym� Oy
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|May 10, 1996
|Nov 14, 1996
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|Combinations of anti-oestrogen compounds and pkc modulators and their use in cancer therapy
|Jun 7, 1996
|Dec 19, 1996
|Board Of Regents, The University Of Texas System
|High affinity tamoxifen derivatives and uses thereof
|Mar 4, 1997
|Sep 12, 1997
|Orion-Yhtym� Oy
|Serum cholesterol lowering agent
|Feb 19, 1999
|Aug 26, 1999
|Orion Corporation
|E-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol and pharmaceutical compositions thereof
|Jun 10, 1999
|Dec 16, 1999
|Endorecherche, Inc.
|Selective estrogen receptor modulator in combination with denydroepiandrosterone (dhea) or analogues
|Nov 1, 2000
|May 25, 2001
|Hormos Medical Corporation
|Triphenylalkene derivatives and their use as selective estrogen receptor modulators
|Jan 26, 2001
|Aug 2, 2001
|Endorecherche, Inc.
|Selective estrogen receptor modulators in combination with estrogens
|May 2, 2001
|Jan 31, 2002
|Hormos Medical Corporation
|Method for the treatment of climacteric disorders in women during or after the menopause
|Mar 21, 2002
|Nov 14, 2002
|Hormos Medical Corporation
|A new method for the preparation of 2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethanol and its isomers
|Nov 27, 2002
|Jun 12, 2003
|Gtx Inc.
|Prevention and treatment of androgen-deprivation induced osteoporosis
|May 14, 2003
|Dec 18, 2003
|Hormos Medical Corporation
|Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
|Jan 19, 2005
|Sep 1, 2005
|Hormos Medical Ltd.
|Solid formulations of ospemifene
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|Citing Patent
|Filing date
|Publication date
|Oct 23, 2012
|Hormos Medical Ltd.
|Method for the preparation of therapeutically valuable triphenylbutene derivatives
|Oct 17, 2013
|Apr 26, 2016
|Fermion Oy
|Process for the preparation of ospemifene
|Sep 16, 2010
|Jan 20, 2011
|Hormos Medical Ltd.
|Method for the preparation of therapeutically valuable triphenylbutene derivatives
|U.S. Classification
|560/60, 560/55, 568/745, 568/731, 568/744
|International Classification
|Cooperative Classification
|European Classification
|Jul 1, 2008
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In a perfect world, we'd have time to shampoo our strands more than once a week. (We'd also sleep eight hours a night and hit the gym instead of the snooze button.) But for all those occasions when life intervenes, this travel-sized bottle of dry shampoo is our secret weapon. The powdery formula revives second-day strands and beyond, absorbing excess oil to provide instant lift.
I hate giving bad reviews but I feel that I owe it to my fellow girls. If I'm going to recommend products then I feel I have to discuss the ones I think should be avoided as well. On that note I'm am not a fan of dry shampoos at all, because I can never seem to find one that does what it says it will. I continue to try them because I believe that washing your hair too often is not necessarily good for its overall health. My hair is naturally oily but it always seems to come out dry, coarse and overly fried whenever I use a dry shampoo. This one was no different. I even asked my brother his opinion and he said it felt harsh and weird. When any guy makes a comment about a beauty product good or bad, that says a lot.1
This dry shampoo instantly adds volume to my hair and gives a clean fresh look. It smells really nice, however it leaves powder residue which, if left on hair too long, is very difficult to brush off and it takes away the shine from my hair. But I still like this product because it leaves a clean look and definitely adds volume.4
I love the scent of this dry shampoo. After using for a little while, I'm not the biggest fan of what it does to hair texture. Makes it feel really dry and brittle. If you are a brunette or any dark color, lift hair and spray at the roots underneath, so the whitish powder doesn't lend a gray hue to your hair. I follow up this dry shampoo with a spray shine or oil to bring back some of the luster.4
I was excited to get this since I have yet to fine a dry shampoo that will work for my hair which is always oily by the second day. When using the product they tell you to let it sit for 2 minutes prior to use. I did just this, the volume in my hair looked good, but the hair had no sheen to it, looked very dull and was sticky to the touch.3
I have been looking for a good dry shampoo for a while and was excited about getting this in my birchbox but it was a lot heavier than other brands and made my hair feel almost waxy. I got an extra day without washing since it did reduce the shine and it didn't make my hair look grey. When I used it exactly as the can directed, it did amazing things for my volume and gave my pony tail some extra oomph. Wouldn't buy full size.3


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warm jacket/nice linng/goodbright color - for PA cold, snowy weather
- How accurate was the sizing? yes
- Please tell us about the quality of the product. warm/good quality
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I am trying to deserialize a JSON string using VB.net and cannot seem to pull the values out of the finished List. Here is the simple class:
Public Class Personinformation
Private theName As String
Private thePic As String
Public Property Name() As String
Name = theName
End Get
Set(ByVal value As String)
theName = value
End Set
End Property
Public Property Picture() As String
Picture = thePic
End Get
Set(ByVal value As String)
thePic = value
End Set
End Property
End Class
Then in the Page_Load I have inserted the following:
Dim JSONstring As String = "[{""Name"":""John"",""Picture"":""mypic.jpg""}]"
Dim json As New JavaScriptSerializer()
Dim outputinfo = json.Deserialize(Of List(Of Personinformation))(JSONstring)
Now I am lost because I can't seem to get the name/value pairs. I tried doing this
I am told "Index was out of range. Must be non-negative and less than the size of the collection."
What am I doing wrong??