text:
Statistical analyses were conducted by Michael Mlynash, MD, MS; Stanford Stroke Center.
Yield of CT perfusion for the evaluation of transient ischaemic attack
Version of Record online: 11 DEC 2012
DOI: 10.1111/j.1747-4949.2012.00941.x
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization
International Journal of Stroke
Special Issue: World Stroke Day Edition 2015
Volume 10, Issue Supplement A100, pages 25–29, October 2015
Additional Information
How to Cite
Kleinman, J. T., Mlynash, M., Zaharchuk, G., Ogdie, A. A., Straka, M., Lansberg, M. G., Schwartz, N. E., Singh, P., Kemp, S., Bammer, R., Albers, G. W. and Olivot, J.-M. (2015), Yield of CT perfusion for the evaluation of transient ischaemic attack. International Journal of Stroke, 10: 25–29. doi: 10.1111/j.1747-4949.2012.00941.x
Conflicts of interest: None declared.
Funding: J. T. K. is supported by the Stanford School of Medicine Medical Scholars program.
Publication History
- Issue online: 26 OCT 2015
- Version of Record online: 11 DEC 2012
- Manuscript Received: 10 AUG 2012
- Manuscript Accepted: 12 JUN 2012
Funded by
- Stanford School of Medicine Medical Scholars program
- Abstract
- Article
- References
- Cited By
- CT perfusion;
- magnetic resonance imaging;
- MR perfusion;
- stroke;
- transient ischaemic attack
Magnetic resonance diffusion-weighted imaging and perfusion-weighted imaging are able to identify ischaemic 'footprints' in transient ischaemic attack. Computed tomography perfusion (CTP) may be useful for patient triage and subsequent management. To date, less than 100 cases have been reported, and none have compared computed tomography perfusion to perfusion-weighted imaging (PWI). We sought to define the yield of computed tomography perfusion for the evaluation of transient ischaemic attack.
Consecutive patients with a discharge diagnosis of possible or definite transient ischaemic event who underwent computed tomography perfusion were included in this study. The presence of an ischaemic lesion was assessed on noncontrast computed tomography, automatically deconvolved CTPTMax (Time till the residue function reaches its maximum), and when available on diffusion-weighted imaging and PWITMax maps.
Thirty-four patients were included and 17 underwent magnetic resonance imaging. Median delay between onset and computed tomography perfusion was 4·4 h (Interquartile range [IQR]: 1·9–9·6), and between computed tomography perfusion and magnetic resonance imaging was 11 h (Interquartile range: 3·8–22). Noncontrast computed tomography was negative in all cases, while CTPTMax identified an ischaemic lesion in 12/34 patients (35%). In the subgroup of patients with multimodal magnetic resonance imaging, an ischaemic lesion was found in six (35%) patients using CTPTMax versus nine (53%) on magnetic resonance imaging (five diffusion-weighted imaging, nine perfusion-weighted imaging). The additional yield of CTPTMax over computed tomography angiography was significant in the evaluation of transient ischaemic attack (12 vs. 3, McNemar, P = 0·004).
CTPTMax found an ischaemic lesion in one-third of acute transient ischaemic attack patients. Computed tomography perfusion may be an acceptable substitute when magnetic resonance imaging is unavailable or contraindicated, and has additional yield over computed tomography angiography. Further studies evaluating the outcome of patients with computed tomography perfusion lesions in transient ischaemic attack are justified at this time.


text:
A Little Help [Blu-ray]
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Jenna drowns her life, which really isn't that bad, into a Budweiser product placement (later replaced by Absolut Vodka) and lies to her mother (Lesley Ann Warren who has aged gracefully) about her life. While sad, it is done in a manner that we must laugh. When Chris dies from an "anxiety" attack brought on by Laura's sudden sexual demand, Laura goes to work the morning of the day of the funeral because it isn't until three o'clock. When Laura is at home, there are times when a dog is barking in the background. It is cleverly symbolic of her tension level.
The movie has some quick dry dark comedy wit:
At the funeral Paul is talking to a woman while opening a bottle of wine:
Paul: This is my second funeral this year, my dad died earlier.
Woman: Oh I'm so sorry.
Paul: Don't be. It was for the best.
Woman: Was he sick?
Paul.: No
Dennis goes to a new school and has the "opportunity to make new friends" as the new fat kid in school. Things don't work out too well until he tells the kids his dad died "in 9-11."
Meanwhile Laura is sent to a lawyer who specializes in medical malpractice lawsuits. Just when you think the movie is going to turn sad and dramatic,like so many indies going down the road of ruin, it doesn't.Read more ›
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Okay, this was a good movie but I have to admit, I have a huge crush on Rob!Published 10 days ago by Kathy
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Good movie. Actually takes a look at life events in a realistic fashionPublished 2 months ago by Jennifer W.
As happens pretty often with these small independent works, I loved this film. Like a lot of the comparable ones I'm thinking of--Little Miss Sunshine, Rachel Getting Married, The... Read morePublished 9 months ago by michael myers
Jenna Fischer shines in this film, I would watch it again for sure! Rob Benedict's performance is stellar, one of my favorite actors!Published 11 months ago by Rebekah
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Released in 2010, "A Little Help" stars Jenna Fischer as a nearing-middle-age mother from Long Island whose marriage is troubled and her family overbearing. Read morePublished 14 months ago by Wuchak
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- List of properties
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172 plots of land for sale found
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A brilliant opportunity to acquire development Land in one of Newport's most sought after locations with planning permission for 9 apartments. The apartments are arranged over two floors and range from 1-3 bedrooms with some having balconys. More details ›
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Gerneous Plot Of Land With Planning A generous plot of land with outline planning permission for five detached residential homes. Granted under reference 09/0090 and renewed on 25/6/2013. Please contact the branch for full details. More details ›
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INSIDE HIGHER ED. JULY 10, 2013. A fire that killed a student Monday at Saddleback College, a community college in California, was set deliberately, The Los Angeles Times reported. Authorities have not figured out whether the male student who died was a victim of the fire or set it.
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Some of the men serving life sentences never committed a crime of violence. They are victims of the three strike law.
Check Out Part 1: "A Poignant 21 Seconds from San Quentin"
"Artists who live and work with spiritual values cannot and should not remain indifferent to a conflict in which the highest values of humanity and civilization are at stake." — Pablo Picasso
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A federal judge in California has denied a preliminary injunction by FOX in its lawsuit against Dish's place-shifting "Hopper" DVR. The ruling comes only a week after a New York judge ruled for Dish against ABC and CBS. In both cases, Dish was allowed to continue both ad-skipping and out-of-home viewing with its "Hopper" technology.
The California case pertains to Dish's Hopper with Sling, also known as "Dish Anywhere," which was introduced at CES last January. In this case, FOX focused not on ad skipping, but on streaming and recording programming over the Internet to be viewed outside the home. FOX claimed Dish not only violated copyright law, but also its contract with the network.
"Today's decision is the fourth in a string of victories for consumers related to our Hopper Whole-Home DVR platform," said R. Stanton Dodge, Dish's general counsel. "DISH is pleased that the Court has sided again with consumer choice and control by rejecting Fox's efforts to deny our customers' access to the DISH Anywhere and Hopper Transfers features."
FOX, as with ABC and CBS last week in New York, did not concede defeat. According to a statement from FOX: "We have just received the ruling, and while the judge found that FOX could prevail at trial on the merits of the case, she did not grant our preliminary injunction. We disagree that the harms caused by Dish's infringing services are completely compensable by damages, and as a result we are looking at all options. We will file a response in due course."
In its motion asking for the injunction, FOX argued that paying Dish for a satellite television subscription did not buy anyone the right to receive FOX's live broadcast signal over the Internet or to make copies of FOX programs to watch "on the go," because Dish did not have the right to offer these services to its subscribers in the first place.
Last week, another federal judge in New York City denied the ABC Network's efforts to block Dish's commercial-skipping "Hopper" video recorder features with its Prime Time Anywhere service. Claims made by CBS were also denied in the case.
With Dish's PrimeTime Anytime feature, users have the ability to record the primetime shows on up to each of the four broadcast networks (ABC, CBS, NBC and FOX) and save them for up to eight days. The AutoHop feature can be enabled by users to play back certain PrimeTime Anytime recordings commercial-free, starting the day after broadcast.
The broadcasters argue that Hopper infringes on their copyrights. ABC added that it also violates Dish's agreement that allows it to distribute the network's programming.
Regardless of the eventual outcome, the court rulings are a clear trend against the interests of broadcasters. Aereo, another thorn in the side of broadcasters, has also established a winning streak in federal courts, which has helped drive its current momentum.
As of this month, the streaming TV service added new services in Chicago, Miami, Houston and Dallas, which went live earlier this week. Aereo began service in New York City and later launched to Boston and Atlanta. Once these four new cities are launched, the company said it would be serving 26 cities (since its launch in New York City in March 2012).
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text:
Electrical problem
1996 Oldsmobile Aurora V8 Front Wheel Drive Automatic 195000 miles
im not sure if I ned a new window motor, requlator or both. The problem is my front driver side window rolls down only halfway. It seems to me the motor works. Thats why im guessing its just the regulator. Can you tell me what it is?
Saturday, April 26th, 2008 AT 5:26 PM


text:
Star Tracks
Bell and Duhamel jump into a fountain on the Italian set of their movie, When in Rome. Plus: Andy Roddick, Beyoncé & Solange, Justin Timberlake and more
Credit: John Shearer/WireImage
Published: Tuesday Jun 24, 2008 | 05:00 PM EDT
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- The Bachelorette's JoJo Fletcher Takes Us Inside That 'Excruciating' Fantasy Suite Rejection


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text: Tim Gunn Visits Gossip Girlnightintern10/26/10 12:53amFiled to: Gossip Girltim gunncwTVIvanka TrumpVideotweet1EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalinkTonight's Gossip Girl was full of cameos from the likes of Ivanka Trump and Isaac Mizrahi. However, the biggest cameo came from sartorial sage Tim Gunn stopping by for Jenny Humphrey's Parsons admission interview.The interview goes well for Jenny until she shows Mr. Gunn her dresses. Advertisement Jenny tries to explain that someone defaced her dresses before the interview. Tim reveals that an old acquaintance had a part in her opportunity. This info leads Jenny to reveal that her night with Chuck cause of her exile and the end of Chuck and Blair's relationship. Like a cowboy, Jenny rides off into the sunset only to return when Manhattan needs her most.Reply1 repliesLeave a reply


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Click any word in a definition or example to find the entry for that word
This is the American English pronunciation of New Scotland Yard.
in competitive cycling, the illegal use of motors on bikes in order to gain advantage over other ridersBuzzWord Article
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Reviewed By cathy k (CALABASH, NC) Reviewed for a 2016 Chevy Colorado —7/24/2016 3:25 PM
I lov this dash cover. It looks great. I've had so many compliments on it.
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Without Youby Masters of Persian Music
Persian classical music isn't a dying form, thankfully. In fact, in the hands of the Masters of Persian Music, you could say it's flourishing. This live recording (no details of when or where, sadly) is a testament to the power of these musicians and singers, all of whom are true virtuosos. In its entirety, the music here is in the mode of dastgah nava, akin to a minor scale, now one of the more popular modes for performance and improvisation. Typical of more contemporary Iranian classical performance, the instruments and voice take an equal role (it used to be that an instrument was subordinate to the voice), with plenty of stunning improvisations on the lute-like tar and the ancient spike fiddle known as the kamencheh. And while choral and harmony singing are unknown in the tradition, here the two singers -- father and son -- aren't afraid to have one voice following the other; in turn, the two instruments work with each other, rather than individually, playing in unison, backing each other, offering antiphonal phrases. It's inevitable, though, that a number of the pieces in the performance are songs (with Mohammad Reza Shajarian in the group, an Iranian national treasure, how could it be otherwise?), and the lyrics, as virtually always in classical music, are taken from the great Sufi poets of history, with their aches of holy desire. The result is far more than the sum of its parts, breathtakingly good in execution, gorgeous in its breadth. Wonderful.
Product Details
- Release Date:
- 10/08/2002
- Label:
- World Village Usa
- 0713746801120
- catalogNumber:
- 468011
Album Credits
Performance CreditsMasters of Persian Music Primary Artist
Hossein Alizâdeh Tar
Mohammed Reza Shajarian Vocals
Kayhan Kalhor Kamncheh
Homayoun Shajarian Tombak
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text: The mime-type of the *.bin file is 'application/octet-stream' and remains so after it is downloaded. Gedit cannot open it, because it is a binary file. However, I agree with you that this is not really a bug in Firefox. -- Firefox first suggestion is to open a *.bin file with gedit https://bugs.launchpad.net/bugs/680615 You received this bug notification because you are a member of Mozilla Bugs, which is subscribed to firefox in ubuntu.


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We need a fruitful way to engage in public conversation about the issues of the day, Sauls says, and Jesus gave it to us.Read the Article
How the study of philosophy, history, art, and science cultivates our love of God.Read the Article
What was missing, many believed, was a way to help people find their place in God's redemptive story. "We wanted to demonstrate that lives are formed and re-formed by that narrative," Herron said. "We wanted to see the Holy Spirit form a Gospel-centered conscience."Read the Article
Trauma is extraordinary, she says, "not because it rarely happens, but because it swallows up and destroys normal human ways of living." We have a choice. "We can flit from one cause to another or, like Jesus, we can leave our place of comfort and enter into the suffering."Read the Article
If a man actually rose from the dead — then business, politics, education, law — these are now saturated with a glorious new purpose.Read the Article


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In my galleries you will find quality fine art photography depicting urban and rural Iowa, beautiful autumn colors from Michigan's Upper Peninsula, and a great deal of other subjects in between.
Be sure to visit my other parallel website. Some of the content will be the same, some will be different.
HOME | Galleries | Blog | Contact & Purchase | About Me | Links


text:
How Obama answers the Boston Bomb attack on the USA,
and what they do with those that attack USA!
Exclusive: Saudi National Once Considered Person of Interest May Be Deported on Security Grounds And How Its Supposed to Be Framed
Apr. 18, 2013 12:30am Jason Howerton
Editors note: Please see the Editors UPDATES we will be placing in order of most-recent below. TheBlazes Jonathon M. Seidl contributed to this report.
Key points:
On Sean Hannitys Fox News program Wednesday night, terror expert Steve Emerson cited sources saying Abdul Rahman Ali Alharbi, the Saudi national who was briefly named a person of interest in the Boston Marathon bombings, is being deported on Tuesday.
Thursday morning, Glenn Beck revealed on radio that TheBlaze was informed by sources that the Saudi nationals visa had been revoked and he was, in fact, going to be deported on security and related grounds.
Among other things, sources told TheBlaze that the Saudi national had ties to a well-connected Saudi family and that his deportation was set to be framed as a voluntary departure to be with his family.
A file, called an event, was started on him three days ago.
While discussing the issue on radio, TheBlazes Chief Content Officer Joel Cheatwood revealed that the government is now considering not deporting Ali Alharbi.
UPDATE VI (12:50 pm ET):
Homeland Security Secretary Janet Napolitano had a fiery exchange with Rep. Jeff Duncan during a House hearing Thursday morning over reports that Al Alharbi is being considered for deportation.
Napolitano refused to entertain a question regarding if it would be negligence to deport someone who just days ago was a person of interest.
Im not going to answer that question, she shot back after being pressed by Duncan and denying any knowledge of such a plan.That question is so full with misstatements and misapprehensions that it is not worthy of an answer.
And she is Head of Homeland Security?
She and Hillary Clinton went to the same school together, "How to get ahead by kissing buts"
Maybe Obama will promote her to "But kissing Czar"
And Hillary Clinton will tell those people killed and maimed to "Suck it up,and move on" (Yeh until they find another 9/11 target)
I understand that the office of Janet Napolitano has been changed, the new name plate says:
"Second Libtard in command". She may get a new plate designating her as #1, as Hillary is no longer Secretary of State(Libtard state that is).
I guess that deporting the Saudi's will be a terrible sentence for the Boston Bomber!!!
And that will make our country safe?????
My Family and I are talking about moving to Texas.
Yeaaa can you handle the heat? Can you handle big bad john? can you hndle the rattle snakes? Can you handle the tornadoes and hailstorms in the springtime? I don,t think your man enough to move down here to texas my friend most yankees are not. We got enough yankees moving down here that is causing our crime rate to go up. Yeaaaa move to colorado.


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Itĺs not his first produced musical, but itĺs the first one heĺs written almost entirely by himself. Morgantown resident Lionel McCulloch, 12 years old, had an idea to write a funny musical about the Three Little Pigs, and the colorful and upbeat show will be produced this month on the stage of the Vagabond Acting Troupe at the Arts House, 30 Fairview Road, Honey Brook, Pa., Chester County, Oct. 18 at 7 p.m., Oct. 19 at noon and Oct. 20 at 2 p.m. On Saturday, Oct. 19, there is a pancake breakfast at 10:30 a.m. (and yes, there will be bacon!) McCulloch, who attends the Agora Cyber Charter School, where he is a 7th grader in 8th grade Language Arts and 9th grade Math, says he was inspired to write the play after the theater company, recently named number 1 on the PHL 17 Hotlist for Childrenĺs Entertainment, ran a poster contest. ôMy friend Dayton Witouski did a poster design for a play that doesnĺt exist Ś ôMakinĺ Baconö Ś with a picture of the behinds of the three little pigs on it. I loved that, and wanted to turn that poster into a real play!ö ôMakinĺ Baconö follows the adventures of three young pigs, played by Jasper Krikorian (Morgantown), Maddie Walker (Coatesville) and McCulloch, as they must go on their own when Mama Pig (Emily Rader of Honey Brook) and Papa Pig (Celia Hernandez) sends them off with a warning to avoid the wolf.For more information on the play, visit the companyĺs website at www.vagabondactingtroupe.org. Tickets are also available on brownpapertickets.com.
If you love music, murder and mayhem, then Berwynĺs Footlighters Theaterĺs production of ôJekyll & Hyde, The Musicalö is just the thing for you this Halloween season. Set in the always spooky, Victorian England, J & H is the tale of a dedicated doctorĺs descent into madness. Itĺs the well-known story, his intentions are good but playing with the ôsacred life-forceö is a prescription for disaster. Allen Puy of Exton is the infamous Jekyll/Hyde. His best friend, Gabriel Utterson (Patrick Ruegsegger, Claymont, Del.) tries desperately to save the good doctor and heĺs aided in this attempt at salvation by Emma Carew (Kelly Quirk, Morton), Jekyllĺs fiancÚe and her father, Sir Danvers Carew (Pete Rolston, Berwyn) all of whom try to steer Jekyll from his destructive path. ôJekyll & Hyde, The Musicalö with book and lyrics by Leslie Bricusse and music by Frank Wildhorn performs at 58 Main Avenue in Berwyn, 19312 on Oct. 18, 19, 25, 26, 31, Nov. 1, 2, 7, 8, 9 at 8 p.m.; tickets $16 / $8 under 18 yrs. and Oct. 20, 27, Nov. 3 at 2 p.m.; tickets $13 / $6 under 18 yrs. Ticket prices are the same online or at the door. For more info or reservations: FootlightersTheater.com.
The Department of Theatre and Dance at West Chester University presents ôGODSPELL, the 2012 revivalö in the Madeleine Wing Adler Theatre/ Performing Arts Ctr. on Oct. 18, 19, 24, 25, 26 at 8 p.m. an Oct. 20 at 2 p.m. The theatre is located at 817 South High Street, West Chester, Pa. Tickets: $12 Students (w/ID), and Senior citizens. $15 Reserved Seating.610-436-2533 Purchase at http://tickets.wcupa.edu/. Originally directed by John-Michael Tebelak, with music and new lyrics by Grammy and Academy Award-winning original composer Stephen Schwartz, the production is a collaboration between Theatre and Dance faculty, students, and professional guest artists from the Philadelphia metro area. Set by the director in present-day Philadelphia, this production updates the universal tale of friendship, loyalty and love based on the Gospel According to St. Matthew with such popular hits as ôDay By Day,ö ôLearn Your Lessons Wellö and ôTurn Back, O Man.ö Godspell is one of the biggest off-Broadway successes of all time. New this year for WCU Theatre and Dance, all production tickets can be purchased online and printed at home. Please go to http://tickets.wcupa.edu/ and for information on this show or 51st Season subscriptions, call 610-436-2533. For more on the WCU Department of Theatre and Danceĺs 51th Season, go to www.wcupa.edu/CVPA/theatreDance.
Peopleĺs Light & Theatre presents ôThe Devilĺs Music: The Life and Blues of Bessie Smithö running Oct. 16-Nov. 24 on the Steinbright Stage. Peopleĺs Light & Theatre is located at 39 Conestoga Road, Malvern, PA 19355. For tickets call 610.644.3500 or visit PeoplesLight.org. ôThe Devilĺs Musicö features the soulful and sultry sound of legendary blues singer Bessie Smith as portrayed by Drama Desk and Lucille Lortel Award-nominated performer Miche Braden. ôThe Devilĺs Music: The Life and Blues of Bessie Smithö was created by a collaboration between Braden, director Joe Brancato, and playwright Angelo Parra. It had its world premiere in 2000 at Penguin Repertory Theatre in Stony Point, NY. Since then, Braden has performed the show in regional theatres across the country, including Off-Broadway in 2011. The play is set in a Memphis buffet flat ľ a private after-hours establishment full of music, spirits, and revelry. Parra imagines the evening before Bessie Smithĺs final moments in 1937 and we encounter the Empress of the Blues performing with a live band, bantering with band leader, Pickle, and telling the audience about her life, love, and career. Braden describes her as ôfeistyö and ôfreeůShe was whoever she wanted to be.ö Director Joe Brancato adds that ôShe doesnĺt accept anything thatĺs mediocre.ö Parra explains that the play is a ôliving entity,ö as Braden constantly refines the work. Each production has been ôunique, effervescent, and more inspiring.ö The play opens on Oct. 19 and runs through Nov. 24. Audiences are encouraged to join the artists for a conversation about the production after the Thursday performances on Oct. 24 and Nov. 7, 14 & 21, 2013.
ôDivaĺs Lamentö will be performed by Tony nominated actress Ann Crumb when The Media Theatre presents the hilarious Monty Python musical ôSpamalotö Sept. 25 ľ Nov. 3. She has appeared on Mediaĺs stage previously in the acclaimed productions ôMaster Classö, ôWings,ö and ôSouvenir.ö In those three productions she was directed by Artistic Director Jesse Cline. ôAnn is a legendary actress who delighted audiences in Andrew Lloyd Webberĺs ôAspects of Loveö on Broadway and in Londonĺs West End,ö Cline said. ôHer talent is extraordinary and she will bring a fresh life to The Lady of the Lake.ö Monty Pythonĺs ôSpamalotö is a comedic musical based on the film Monty Python and the Holy Grail. It received the 2005 Tony Award for Best Musical. Much like the classic film from the Ĺ70s, it follows a non-traditional and surreal strand of humor as King Arthur journeys to find the Holy Grail. The King recruits several eccentric and somewhat ridiculous Knights for his quest. Along the way they meet The Lady of the Lake, Prince Herbert, The Knights of Ni and a few other bizarre characters. For tickets to Monty Pythonĺs ôSpamalotö at The Media Theatre, call 610-891-0100 or visit mediatheatre.org.
Peopleĺs Light & Theatre presents N. Richard Nashĺs ôThe Rainmakerö running Sept. 18-Oct. 13 on the Leonard C. Haas Stage. Abigail Adams directs. Peopleĺs Light & Theatre is located at 39 Conestoga Road, Malvern, Pa. 19355. For tickets, call 610-644-3500 or visit PeoplesLight.org. Peopleĺs Light and Theatre Company opens its 2013-14 season with a sweet note of romance in ôThe Rainmaker.ö This heartfelt classic is set in 1936 during the late summer in the sweeping landscape of Western Iowa at a time of drought. Cattle are ôdown and outö on the Curry ranch and temperatures are a stifling 104 degrees at night. As the relentless sun scorches the grassesĺ verdure and desperation creeps into the charactersĺ lives, a young womanĺs search for love begins when a picaresque stranger with a ômellifluous tongueö enters and claims that he can bring rain. ôThe Rainmakerö opened on Sept. 21 and runs through Oct. 13. Single tickets: $26 - $46. For tickets, call the Box Office at 610.644.3500. Special discounts are available for groups of 10 or more. For more information or to purchase group tickets, call 610-647-1900 x111 or email email@example.com.
Walnut Street Theatre opens its landmark 205th season with the groundbreaking 21st century musical ôIn The Heights.ö Directed by Bruce Lumpkin, with choreography by Michelle Gaudette, this exhilarating musical about chasing your dreams and finding your true home opened on Sept. 11 and runs through Oct. 20 on the WST Mainstage. ôIn The Heightsö tells the universal story of a vibrant community in New Yorkĺs Washington Heights neighborhood ľ a place where the coffee from the corner coffee shop is light and sweet, the windows are always open and the breeze carries the rhythm of three generations of music. Itĺs a community on the brink of change, full of hopes and dreams where the biggest struggles can be deciding which traditions you take with you, and which ones you leave behind. With a gripping story and incredible music and dance, ôIn The Heightsö is the next chapter in the classic American story. For tickets and information, call 215-574-3550 or 800-982-2787. Tickets are also available online 24/7 by visiting www.WalnutStreetTheatre.org or Ticketmaster.
Peddlerĺs Village Murder Mystery Dinner Theater series in the Peddlerĺs Pub at the Cock Ĺn Bull Restaurant is performing ôBewitched, Dewitched,ö Friday and Saturday nights now through Dec. 28. The cost for the show is $51.95 per person, which includes dinner, show, tax and service charge. Produced by Without Cue Productions, ôBewitched, Dewitchedö promises an evening full of fun and suspense! All ôpeople of magicö have lost their powers, and Samantha Stephens has called a special Witchesĺ Council. Aunt Clara still has a few spells left, and she summons a detective to help. Unfortunately, the detective she summons is the bumbling Inspector Clouseau of Pink Panther fame. Understandably, the Inspector has difficulty coping with witchcraft and murder, but perhaps he can solve the mysteryŚwith the guestsĺ help! Guests should arrive in the lobby of the Cock Ĺn Bull Restaurant by 7 p.m. Cocktail service is available. Groups are welcome. For mature audiences only, children under 18 are not permitted to attend. Reservations are required for the Peddlerĺs Village Murder Mystery Dinner Theater. For more information and reservations, call 215-794-4051.
The national tour of the hilarious new show ôYou Say Tomato, I Say Shut Up!,ö a relationship comedy that People magazine called ôLAUGH OUT LOUD!ö, continues its tour with a premiere in Philadelphia at the New Pennĺs Landing Playhouse (inside the Independence Seaport Museum) 211 S. Columbus Blvd. and Walnut St. Opening night was Oct. 2 and the show will run through Dec. 29. Presented by Philip Roger Roy and Dana Matthow, ôYou Say Tomato, I Say Shut Up!ö is the hilarious comedy about relationships, love and marriage. After 17 years of marriage, writers-actors-and real-life-married-couple Annabelle Gurwitch (ôDinner and a Movie,ö Fired!) and Emmy Award winner Jeff Kahn (ôThe Ben Stiller Show,ö The 40-Year-Old Virgin) have adapted their hilarious, often moving, memoir for the stage, directed by Van Kaplan. It stars Robin Abramson and Gregory Johnstone who have been hailed for their roles in this play. ôYou Say Tomatoö will run in the evenings on Wednesdays at 7 p.m., Thursdays at 7 p.m., Friday and Saturdays at 8 p.m. with matinee performances at 2 p.m. on Wednesday, Saturday and Sunday. Ticket prices are $35 to $55 on Wednesdays and Thursdays and $45 to $60 on Fridays, Saturdays and Sundays. Group rates begin with 12 tickets. To purchase tickets, call 855-448-7469 (855-HIT-SHOW) or order online at PLPlayhouse.com. Group tickets begin with 12 tickets and can be purchased by phone at 1-888-264-1788 or through e-mail at firstname.lastname@example.com.


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Four-way stop proposed for wreck-prone road
Published: Tuesday, August 12, 2008 at 3:00 p.m.
Last Modified: Tuesday, August 12, 2008 at 2:38 p.m.
THIBODAUX A heavily-traveled intersection near Thibodaux High School, long the
site of fender benders, may soon be safer.
But the four-way stop proposed for the spot will likely result in increased traffic and
a slower commute.
A study by Thibodaux Police, presented to Thibodaux City Council members last
week, made clear what many nearby residents say they already knew: theres about
a wreck a month at Tiger Drive and Plantation Road.
Through 2002 to 2006, it was the scene of 23 reported wrecks, four of those
resulting in minor injuries.
In response, City Council members said theyll decide Tuesday whether to erect a
four-way stop sign at the corner.
They acknowledge that if they do so, this thoroughfare routinely used by area
residents, W.S. Lafargue Elementary parents and some of Thibodaux High
Schools 1,600 students, could become heavily congested.
I dont want to hamper traffic, but I also dont want to cause a situation where a
serious accident could occur, Councilman Chad Mire said.
The road features a stop sign for traffic heading in either direction on Plantation
Road, but motorists on Tiger Drive have clear passage.
About 2,000 feet south of the intersection lies Thibodaux High School, where
students pour out on foot, in cars or in buses as soon as school ends in late
afternoon. A half-mile east of the intersection is W.S. Lafargue, which officials say
will be less affected because motorists often take different routes from the school.
Adding to the congestion is traffic from St. Genevieve Catholic Church and its
school, about a mile north of the intersection.
Anyone having encountered the intersection while traveling east or west on
Plantation Road can tell you that it is sometimes tough to navigate north-south
traffic on Tiger Drive from this location, Police Chief Craig Melancon said in the
Mire and other council members say they will likely vote in support of a four-way
stop sign. But Mire adds that his decision comes with some hesitation, as hed
prefer to see an officer directing cars during peak traffic hours.
If we see theres a problem, maybe we can rescind it, he said.
Residents of the community interviewed Monday say they share concerns of safety
and would welcome a four-way stop.
They do have a lot of wrecks, said Vanessa Smith, a lifelong resident of the
neighboring community. If they got the money, why not?
Thibodaux Police conducted interviews, mostly with people who work in the area
but live elsewhere. It yielded mixed results.
Of seven people, four said they supported a four-way stop and three wanted it left
as is.
Six of those rated the traffic as busy or unsafe. The other described the
intersection traffic as OK.
Nonetheless, Melancon concluded, a four-way stop is needed to prevent further
Its clear that this intersection, as is, is a challenge to motorists, he states in the
Council members say they will consider the issue at 5 p.m. today at 310 W. Second
St. in Thibodaux.
Staff Writer Ben Lundin can be reached at 448-7635 or firstname.lastname@example.com.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
Comments are currently unavailable on this article


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Elk 45 Self-Contained Electronic Siren
Usually leaves our warehouse the same business day.
The ELK-45 is a loud self-contained electronic siren in a compact and attractive housing. This siren draws less current than many competitive units and features the ability to produce two distinct sounds from a single input trigger. The ComboTrigger option allows controls which have a single alarm output and pulsing option to activate both the burglar and fire alarm sounds. The ELK-45's removable "U" shaped mounting bracket makes installation quick and simple. ItÂ's small and compact size allows it to be placed in vents, attic eaves and soffits, and other unique locations where large and bulky units will not fit. Also available is the ELK-150RT which is the selfcontained siren in a stainless steel enclosure. Specifications: Operating Voltage: 6 to 14 Volts D.C. Current Draw: 1.2 Amps Sound Level: 118 dB @ 1 meter, 14 Volts D.C. Size: 4" x 4" x 3.5", Depth 4".


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In this installment in our series exploring the anarchist critique of democracy, guest author Uri Gordon discusses the attractions and risks of democratic discourse.
Like most political words, democracy is an "essentially contested" concept—its meaning is itself a political battleground. What political ideologies do, as mass patterns of political expression, is to "de-contest" or fix the meaning of such concepts and place them in particular relationships. The term "equality," for example, can mean equal access to advantage (liberalism), equal responsibility to the national community (fascism), or equal power in a classless society (anarchism). On such a reading, there is no way objectively to determine the meaning of such concepts—all that exists are distinct usages, each of them regularly grouped with other concepts in one or another ideological formation.
I would therefore like to suspend the discussion of the appropriate conceptual understanding of democracy, and instead ask about the strategic choice to employ the term. Is it worthwhile for anarchists to de-contest "democracy" in ways that point towards statelessness and non-domination? Two arguments follow. The first is that anarchist invocations of democracy are a relatively new and distinctly American phenomenon. The second is that the invocation is problematic, because its rhetorical structure and audience targeting almost inevitably end up appealing to patriotic sentiments and national origin myths.


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Welcome to the Brazos County A&M Club website. It is our goal
to provide you with an easy to navigate site with beneficial information. The mission of the Brazos County A&M Club is.....
We are glad to have you on our website and hope to see you at an event soon!
Click here to see a list of our current members.
BCAMC Upcoming Events
The 2016 Membership Campaign for the Brazos County A&M Club is underway!
Sign up today!
P.O. Box 4 College Station, TX 77841 979.775.0336


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- Swimmer Ryan Lochte reveals one of his worst dates - US Weekly
- Get the latest on Dr. Dre's arrest - TMZ
- Despite rumors, Eddie Murphy's daughter is not pregnant - Gossip Cop
- The Vampire Diaries star Michael Trevino steps out for a good cause - Just Jared Jr
- Are Blac Chyna and Kylie Jenner on good terms? - Radar
- Blue Ivy is just as stylish as her mom Beyonce! - Lainey Gossip
- This Narcos star confirms he's not coming back for another season of the show - The Hollywood Reporter
09 January 2014 at 10:37 PM
Abbie Cornish & Richard Madden: 'Klondike' TCA Panel!
About this photo set: Abbie Cornish and Richard Madden sit front and center while speaking onstage during the Klondike panel discussion at the Discovery Communications portion of the… Read More Here
Photo #: 3026527
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"Another Great Eagle Scout Project" Sign$14.99Posted at the site of an Eagle Scout Project, this sign is a great way to highlight Scouting's efforts in the community and recognize the Eagle Scout and his unit! Sign measures 26" x 16" and comes with a three-piece, collapsible metal frame that's easy to secure in the ground. Be sure to write your name and unit number on the bottom with a permanent marker. Learn More
Scoutreach Boy Scout™ Recruiting Fliers, 500 packOriginal Price:$16.99 Current Price: $11.98500 per package. Learn More
Handbook for Boys (1911)$16.49Take a step back in history with this soft-cover reproduction of the original 1911 edition of the BSA® Handbook. Charming and anecdotal, it's full of wisdom and information that Scouts will still find relevant today. 400 pages. Learn More
FOS Laser Statement Form$18.99This is a shrink-wrapped pack of 500 perforated sheets, which yields 1,000 finished forms. Learn More


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Focus Shifts in Pro Bono Effort to Make Storm Victims Whole
Thursday, December 27, 2012
- Organization: CT Law Tribune
- Link: http://www.ctlawtribune.com
James Mason is an associate attorney in Dorsey & Whitney LLP's Minneapolis office. He volunteers with Volunteer Lawyers Network (VLN) in its criminal expungement workshop. At the workshops, volunteer attorneys like James help people complete the lengthy and detailed court pleadings required for expungement using the HotDocs assembly tool hosted on ProJusticeMN.org. READ MORE
Legal info for the public
LawHelp.org Named Best Law Site in 2007 Webby Awards


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346 posts tagged with nostalgia.
Displaying 201 through 250 of 346. Subscribe:
1981 Atari Catalog
It's the 1981 Atari product catalog!
Let's go Nintendo
The Greatest Show on Earth
Under the Big Top: Shhhhhh! The Show's about to start*... quick, take your seat, sit down, and don't make a move. It's been going on for centuries, and now--lucky you will be able to be a part of it, if you haven't already as a child (1, 2, 3, 4, 5). Honestly, who hasn't thought of running away from home and joining the Circus (but I'd suggest you wait a couple of years, until you're a little older, and a little wiser, to make these decisions). It is tempting though, when they roll into town with their fancy wagons, and their loud music. Although, the circus may not be as prevalent as it once was, there are new acts being created to entice crowds around the world. [previously]
Come Aboard, We're Expecting You...
If you were a North American kid (well, a kid stuck at home, younger than driving age) in the late 70s/early 80s, your Saturday nights were likely spent in front of the television watching The Love Boat. The show subsequently gained worldwide popularity. Did you know that the Pacific Princess is still ferrying the lovelorn across the blue abyss, and that she has a bridgecam? Did you know there were Love Boat action figures? For your nostalgic pleasure: complete episode guide, complete guest star list, theme song video (variations 1, 2, 3), lyrics and chords, and song facts.
Somewhere in the crowd... sometimes you find someone very special. Someone who sees light in the dark.
Between 1981 and 1984, the first network for kids broadcast an unusual show called THE THIRD EYE [more inside]
Our Feature Presentation
If you had HBO in the 80's, you saw this every night at 8pm. HBO put together a brief behind-the-scenes featurette showing everything from the construction of the models to the composition of the music.
The Marvel Assistant Editors' Month
Back in 1983, before crossovers and limited edition covers ruined the industry, Marvel had a really great idea for a special month of comics. [more inside]
Classic British Children's TV
"Well you know my name is Simon/ And the things I draw come true/ Oh, pictures take me over, over / Across the ladder with you." Little Gems is an extensive collection of information (including downloadable theme songs) about (mostly) British children's TV from the 1960s to 1980s. Simon In The Land of Chalk Drawings, The Moomins [previously on MeFi], Cockleshell Bay, Belle and Sebastian, The Herbs, and Hattytown Tales are just a few.
It's Slinky, It's Slinky
Don't Look Back In Anger
Rhino Releases The Brit Box It's hard to explain in 2007 what it feels like for music to be both uniting and important. Having spent nearly three years of the '90s living in London, it's with honest nostalgia and wonder that we examine Rhino's The Brit Box. The set's mission is rather broad: it attempts to examine the whole of UK indie rock from 1985-1999 and devotes a disc each to '80s indie, shoegaze, Britpop, and the late '90s. [more inside]
This is serious-- we can make you delirious
Retrostatic is a treasure trove of 80's (and 90's) TV commercials--from PSAs of singing pills to the Post cereal Create-A-Villain contest (and so much more). Also, cartoons, with descriptions and opening sequences of everything from Alf Tales to Thundercats.
Shortwave and AM Radio from the Kitchen
The Radio Kitchen is an mp3 blog dedicated to the late night wonder of listening to shortwave and AM radio, now and as it used to was. Brought to you by The Professor from WFMU's defunct AM and Shortwave Radio blog). [more inside]
Vintage Flight Attendant Photos
Remember when air travel was viewed as glamorous and exciting? Of course you don't. So check out this collection of vintage flight attendant photos: Part 1, Part 2, Part 3
24: The Unaired 1994 Pilot
It's 1994, there's a bomb in Los Angeles, and THERE'S NO TIME! Will Jack Bauer save the world with AOL 3.0?
Some Old Ass Movie With Skaters who, uh, date, kinda.
Noel Black's first project after graduate film school at UCLA was writing and directing Skaterdater, a short subject cinematic romance without dialogue, which used only music and sound effects to advance its plot. It won nine international film awards. [more inside]
Nerd It Through The Grapevine
Raisin Hell, a tale of fourth-grade Halloween woe by Eric Feezell. "I was deep in thought, mulling over ideas for a Halloween costume, a fresh, heart-stopping one. Something that had never been done before... Suddenly I witnessed something stupendous. Instantly, any ounce of reason contained in my young mind evaporated. I saw a California Raisins commercial." For reference: a list of California Raisins commercials on YouTube.
What was your first concert?
Mine was The Fixx opening for A Flock Of Seagulls in '82 when I was 12 and it was the first time I smoked dope... I know this is the worst kind of query-Metafilter post but I can't resist. It is a fun article and I bet you have a better story.
Pre-Videogame Era Toys
Before there were videogames, growing up in England in the late 1960s though the 70's we had Action Transfers. The Letraset company branched off its division of hand set rub-on transfer fonts into full blown action scenes, with Cowboys & Indians, famous historical battles, Vikings, natural disasters & more. This collector has dozens of sets, scanned in high resolution & never used.
At least you won't die of dysentery in this one.
Thule Trail is a cute modern remake of The Oregon Trail.
Steven Banks Home Entertainment Center
it wouldn't be make believe if you believed in me
It's only a paper moon - a charming vintage photo collection. (via recogedor)
His darling Bumblebee
Making a Transformer out of KFC buckets and custard pie boxes. [more inside]
Wishbook Web -- Christmas Catalogs through the 20th Century
Wishbook Web. Christmas catalogs scanned in their entirety from the 1944 Wards Catalog (152 pages) to the 1985 Sears Catalog (648 pages!). The site looks like it was built circa '97, but the scans are quite interesting. via - Similar posts to this one: 1, 2.
The Idiot's Lantern
It is Saturday morning at 8:00. It's 1969. Your parents are asleep. What'll it be? CBS of course, with The Jetsons, then The Bugs Bunny and Roadrunner Hour, Dastardly and Muttley and their Flying Machines, The Perils of Penelope Pitstop, Scooby Doo, The Archies, The Monkees, The Wacky Races, The New Adventures of Superman and Jonny Quest. On Channel 4 NBC fights back with Heckle and Jeckle, then The Grump, The Pink Panther, HR Pufnstuf, The Kellogs Banana Splits Adventure Hour, Jambo, The Flintstones and Underdog. Channel 7 is ABC which trails with Casper, then Cattanooga Cats, Hot wheels, The Hardy Boys, George of the Jungle and Fantastic Voyage. Good times.
It's Also Acetaminophen-riffic.
Ready for '90s nostalgia yet? Well, throw some flannel on your Furby and get ready for that decade's most migrane-tastic fad, the autostereogram, or Magic Eye. Of course, the Web can't leave anything alone, so you can watch a moving autostereogram, play a little wall-eyed Tetris or Pong, and create your own image to delight and annoy your friends.
Count on it.
1, 2, 3,4, 5,6,7, 8, 9,10, 11,12! Classic Sesame Street taught us Counting and other important stuff.
Sorry, No Throbbing Gristle
Although Industrial Musicals and their jaunty odes to corporate pride and brand loyalty have seen the same fate as the values they espoused (mostly), goofily earnest and undeniable catchy tunes like Exxon's Up Came Oil♫, General Electric's Make a Woman Out of Your Wife♫, and The Monroe Calculator Company's 1660 & 65♫ are still as potent as all get out! [More songs and albums to help you get your gray flannel funk on inside]
Charlie Parker, gunslinger
Thomas Sutpen is one of Faulkner's most complex and intriguing characters. His blog, If Charlie Parker was a gunslinger, there'd be a whole lot of dead copycats includes nostalgic collections of rare photographs in serial form. Samples: They Were Collaborators (298) Great Con Artists of the 20th Century (14) Vietnam - Dramatis Personae (7) A is for Arbus (37) Collect 'em All (26) The Golden Age of Prurience (37) Poets are both clean and warm (18). Many wonderful others on the sidebar.
Norman Rockwell reconsidered
Innocence is constructed by disavowing things that are right in front of your face. Richard Halpern, professor of English at Johns Hopkins University, published a different take on Norman Rockwell's art in Norman Rockwell: The Underside of Innocence. He looks below the idyllic surface of nostalgic Americana and sees unwitting voyeurism and blurred boundaries "between asexual friendship and Eros". Naturally, many Rockwell fans don't want to hear this about their beloved painter of innocence: an article about this book in the Boston Globe drew quite a few scathing comments. (BugMeNot logins for the Boston Globe website)
This has destroyed my productivity, now it can destroy yours...
Steem is an Atari ST emulator for Windows and Linux that is very simple and user-friendly. More details on installing are in a helpful beginner's guide, but you're probably most interested in the games, of which there are lots [more inside].
There are no windows and no doors. Of course, there's always MY way out.
Virtual Space Mountain! Wheeeee! (Click on the second video where you sit in front. What are you, a wuss?) Real video just can't do Space Mountain justice, but it does a pretty good job of capturing some other rides. Feel like revisiting some original Magic Kingdom rides without leaving home? Well here you go... Pirates, Mr. Toad, Small World, Haunted Mansion, Tiki Room, Thunder Mountain, Star Tours, Indiana Jones, Alice in Wonderland, The Jungle Cruise, Matterhorn, Roger Rabbit, the late Swiss Family Robinson Treehouse and a bunch of people covered in lightbulbs dancing to the world's most excruciatingly annoying synthesized music. During your virtual day at the park, please just remember to watch out for Goofy. That dude is nothing but a messed up troublemaker. And don't forget... the parking trams do not go to aisles B as in Bambi & C as in Cinderella.
Fun, Fun, Secret Fun
Secret Fun Blog. A mixture of pop-culture artifacts, retro goodness and childhood nostalgia. Don't miss the audio and video offerings. [Secret Fun Blog is an auxiliary of Secret Fun Spot, which appeared on Metafilter in 2002 and is worth revisiting as it has been greatly expanded and updated since then.]
Dead Sodas
Pepsi Blue, et al. Dead soda visited by X-Entertainment, purveyors of much 80s-90s nostalgia. Previously.
'To an Eastern man this city is full of surprises. '
Ghost Cowboy :: True Tales of Adventure in the American West
Billed as TV's frst video arcade game show, Starcade had its contestants battling each other on video game trivia, as well as actual gameplay. Originally aired in the early 1980's, the show featured games like Zaxxon, Congo Bongo, Star Trek and Journey, to name a few.
Ten full episodes are available online, for those of you who want a bit of video game nostalgia. And, if nothing else, looking at the contestants is pretty entertaining, in and of itself.
Ten full episodes are available online, for those of you who want a bit of video game nostalgia. And, if nothing else, looking at the contestants is pretty entertaining, in and of itself.
A blast from the past
The Usborne Guide to Computer Games 1982 is full of fun ways to make traditional video games more exciting and contains some very accurate predictions.
The Ultimate Christmas Video Collection
101 Classic Christmas Videos The winter solstice is nearing, and Rudolph's on his way. So whether you're celebrating Festivus, or just being a blockhead, why not kick back with a nice glass of egg nog and a holiday classic?
A video history of rave
Classic UK Hardcore Breakbeat videos. John Tab, a Washington DC-area Drum and Bass DJ, has been scouring you tube for classic UK hardcore and jungle videos from the early 90s and offering them up with commentary.
Vintage Radio and Scientific Equipment
The Spark Museum John Jenkins' collection of vintage wireless, radio, scientific and electrical equipment, including Crookes and Geissler tubes, Barlow wheels and other early electric motors, loudspeakers and many more oddball electrical devices. [via TeamDroid]
Remember, remember
It being the 5th of November and that… here's a bit of fireworks nostalgia.
This Is Not An REM Song
The Automat was a remarkable, culturally ubiquitous part of the history of both Philadelphia and New York City. The basic concept wasn't unusual, but the Art Deco style was unique. Now, BAMN! Food has revived the concept and the name.
Lunch in loud, brightly lit rooms
Either you liked them or you didn't, but for 60 years, the National School Lunch Program has been feeding American school children low cost, nutritious meals. Personally, from the 1960's, in small town Kansas, I miss the fish sticks, the thick oil crust sheet pizza, and the corn bread. And subsidized milk, at 2 cents an 8 ounce carton.
Retro Product Packaging of the 50s, 60's & 70's
Dan Goodsell (of the unbelieveably great - and previously linked - Tick Tock Toys) has been keeping a blog for the last six months or so covering a variety of subjects (including his webcartoon, Mr Toast), but largely focused on U.S. pop culture ephemera of the 50's though the 70's, with a ton of great stuff.
HOWTO: Host an orgy
Everything I Know About Canada, I Learned During The Commercials...
A collection of NFB Vignettes that taught a generation of Canadians about archetypal norsemen, hydraulic treeshears, birling, how to speak French without having to learn it, and more! (YouTubeorama) (Vignettes previously discussed on MeFi in this Hinterland Who's Who FPP)
play c64 games online
c64s is a pretty amazing site. Much of the popularity of the old c64 was in its wide array of games and this site offers a way to play most of the popular ones all in your browser (in java). Waste time today by reliving those old early 80s memories.
The Monster at the end of this e-Book
The Monster at the end of this e-Book. Grover, it turns out, is among the best of the web. And since we're already here, little Robert's and Haley's reimaginings via "Kay's Home Page" (Grover lesson plan included).
The SF quake
The Bancroft Library unveils a new 1906 San Francisco Earthquake site featuring a really cool clickable map that features photos from each section of town. Haight Street didn't look too bad, but just down the road, City Hall was leveled. The exhibit offers a guide to the event that look place nearly 100 years ago.
Selling the Mertzes
Fred and Ethel resurrected as corporate shills "Through the magic of Hollywood, famously tightfisted Fred (William Frawley) and his irascible wife, Ethel (Vivian Vance), are brought back to life in a series of entertaining vignettes," California-based PacifiCare said in a release about its new television advertising campaign. Using body doubles, voice impersonators and computer-generated imagery, the national TV ads that will premiere in mid October will enable the two long-dead actors to "speak" once more. And, oddly enough, they'll be talking about PacifiCare's new drug plan.
Someone has to draw the line.
You can't POSSIBLY be serious. The fact that modern breakfast foods (or at least, foods normally associated with breakfast) have expanded to include items such as cereals whose marshmallow content threatens to outweigh the actual nutritious content, slightly more nutritious items covered in frosting, and of course, the wide variety of chocolate flavored items, cereals, milk, muffins, and so on. But that's just breakfast. Now, however, we're getting into personal hygiene. And that may just be Snakes On A Plane dangerous.


text:
BYU graduate may have found draft of U.S. Constitution
society's records, the page Toler believes is a third draft of the
Constitution has been filed away in a box marked simply "James Wilson:
Volume Two" since at least 1970. Toler suspects the document has been
in that box since it was first transcribed by Yale scholar Max Farrand
in 1911.
"It was just sitting there, forgotten," Toler said.
to Farrand's writings, in 1911, he connected the three-paragraph
introduction on the back of Wilson's first draft to a document titled
"The Continuation of the Scheme," Toler said. The paper Toler found is
also called "The Continuation of the Scheme."
She doesn't believe it's a coincidence.
Not everyone, however, is as excited.
pretty skeptical," said Andrew Shankman, an associate professor of
history at Rutgers University in New Jersey, shortly after examining
the paper. "It doesn't appear to fit with the known drafts of the
Specifically, he
said, the numbering system between the three-paragraph fragment and
"The Continuation of the Scheme" don't seem to match up, he said. The
style is less formal than Wilson's other drafts.
acknowledged the inconsistent style between drafts but attributed the
differences to a "more relaxed, scatterbrained" Wilson, she said.
is significant because James Wilson was always polished in front of
others," Toler said. "To me, the way these documents were written
demonstrates that he worked alone on this project for some time. These
are his raw thoughts."
As of
Thursday, Shankman was the only established scholar who had evaluated
Toler's claims. The historical society is in the process of obtaining a
more thorough evaluation.
Arnold, senior director of the library and collections at the
Historical Society of Pennsylvania, denied that the document had ever
been lost. It was never recognized as a legitimate draft of the
Constitution, he said, so it was kept in a file of Wilson's notes from
the Constitutional Convention.
"It was right where it should have been," he said. "In a box labeled 'James Wilson.'"
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text:
If ordered today, we estimate your order will be printed, packed and ready for shipment on Wednesday, July 27.
Floral Ampersand - Invitation
Item Number: DWF23813LDV
Floral Ampersand - Ecru - Invitation
Description and Details
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- Price Includes: Invitations, Inner and Outer Envelopes
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- Wording Shown: Verse W27
- Personalization Options: Your choice of ink colors, fonts and wording.
- Recipient Addressing: Available
- Sample Price: Samples range in price from $.99 to $1.99.


text:
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These analyses of the COMBINE Study were designed to examine the effects of naltrexone among African Americans during the course of the 16-week treatment. Participants (total n = 100; 70% male) who received naltrexone during the 16-week treatment trial (n = 51) were compared to those who received placebo (n = 49), controlling for acamprosate and behavioral intervention. Results did not support the efficacy of naltrexone on percent-days abstinent, time to first heavy drinking day, and global clinical outcome in this subsample of African Americans. These results suggest that further work is needed to test naltrexone, as well as other medications, in this population and to identify treatment responders via genetics or other psychosocial predictor variables. Implications for pharmacogenetic studies of naltrexone are discussed.
Naltrexone (NTX) is an opioid receptor antagonist with empirically supported efficacy for the treatment of alcoholism when used in combination with behavioral treatments (Srisurapanont and Jarusuraisin, 2005). Shortly after two initial trials suggested that naltrexone resulted in significantly fewer drinking days and lower rates of relapse after three months of treatment (O'Malley et al., 1992; Volpicelli et al., 1992), naltrexone was advanced as one of the more promising pharmacological interventions for alcohol dependence (Litten et al., 1996). More recent trials of naltrexone have generally demonstrated beneficial effects on heavy drinking rates, particularly among those who are compliant with the medication (Anton et al., 1999; Chick et al., 2000; Monti et al., 2001; Morris et al., 2001). Results from the COMBINE Study have also supported the efficacy of naltrexone in combination with medical management (MM), an intervention delivered by health care professionals and focusing on psychoeducation, medication adherence planning, and abstinence recommendation (Anton et al., 2006).
Treatment response to naltrexone, however, is not uniform and while some patients seem to benefit from this pharmacotherapy, others do not. Recently, genetic markers have been examined as predictors of clinical response to naltrexone for alcoholism. Studies have found that carriers of the Asp40 allele of the gene coding for the mu opioid receptor (OPRM1), which represents the principal target of naltrexone, show better treatment response to this medication, as compared to homozygotes for the major (Asn40) allele at this locus (Anton et al., 2008; Oroszi et al., 2008; Oslin et al., 2003). These results may be related to higher alcohol-induced reward among carriers of the Asp40 allele (Ray and Hutchison, 2004) and higher naltrexone-induced blunting of alcohol reward among these individuals (Ray and Hutchison, 2007). Nevertheless, there are important ethnic differences with regard to the estimated frequency of this possibly treatment-informative polymorphism. The estimated minor allele (Asp40) frequency is approximately 20% in individuals of European Ancestry, 58% in Asians, and < 5% in individuals of African descent (www.ncbi.nlm.nih.gov/projects/SNP). To the extent that this polymorphism of the OPRM1 gene may predict clinical response to naltrexone, individuals of African descent would possibly be less likely to benefit from naltrexone, at least through the mechanisms conferred by this genetic variant. In light of the literature on the pharmacogenetics of naltrexone, the analyses of the COMBINE Study (COMBINE Study Research Group, 2003a; 2003b) presented herein were designed to examine the effects of naltrexone among African Americans during the course of the 16-week treatment.
The rationale and methods of the COMBINE study have been described in detail elsewhere (2003a; 2003b). In brief, COMBINE was designed to test the outcome of different levels of pharmacotherapy and psychotherapy interventions for alcoholism. A total of 1,383 participants were recruited at 11 U.S. sites, including 109 African Americans (AA) which represent the focus of this report. All participants were outpatients who met criteria for alcohol dependence and who had been drinking heavily for the 90-day period preceding study entry [heavy drinking was defined as > 21 drinks (> 14 for women) per week with at least 2 heavy drinking days (i.e., ≥ 5 drinks in a day for men; ≥ 4 drinks for women) during a consecutive 30-day period within the 90 days prior to the baseline evaluation] (Anton et al., 2006). Exclusion criteria were any serious mental illness or unstable medical conditions, current dependence on any drug other than alcohol, nicotine, or marijuana, and taking or requiring any medication that interfered with the study medications.
Participants were randomly assigned to one of nine treatment conditions and received 16 weeks of active treatment. Eight of these groups (AA, n = 100) received medical management plus either active/placebo naltrexone or active/placebo acamprosate. These four medication groups were then further divided by two levels of behavioral counseling (i.e., Combined Behavioral Intervention [CBI] vs. no CBI). A ninth group (AA, n = 9) received CBI alone, without MM or pills and will not be included in the analyses presented herein given the focus on naltrexone response. In this study AA individuals who received naltrexone during the 16-week treatment trial (n = 51) were compared to those who received placebo (n = 49) regardless of psychotherapy intervention or use of acamprosate. The sample size was adequately powered (i.e., power ≥ .80) to detect medium-to-large effect sizes (Cohen, 1992).
Outcome variables and covariates were culled from the COMBINED database. The Form 90 (Miller and Del Boca, 1994; Tonigan et al., 1997) was the primary measure of drinking outcomes. The outcome variables and related analyses were identical to those in the main report (Anton et al., 2006): (a) percent days abstinent (PDA); (b) time to first heavy drinking day (TTHD), operationalized as 5 or more drinks in a day for men and 4 or more drinks for women. In addition, we examined the effects of naltrexone on global clinical outcome (GCO), a composite measure of alcohol treatment outcome that takes into account alcohol consumption and alcohol-related problems (Cisler and Zweben, 1999). CGO classifies participants into one of four categories: 1 = abstinent, 2 = moderate drinking without problems, 3 = heavy drinking or problems, and 4 = heavy drinking and problems, which are further combined into either good clinical outcome (1 and 2) or not (3 and 4). The following analyses were conducted: (a) PDA was tested using a mixed effects general linear model; (b) TTHD was tested using a proportional hazards model; and (c) GCO was tested using a logistic regression. All models controlled for drinking at baseline (PDA), acamprosate, and CBI. Analyses were performed using SAS Statistical Software, version 9.1 (SAS Institute Inc., 2003), and using identical syntax to that of the main COMBINE Study analyses (Anton et al., 2006). Interactions terms were removed from the original models due to reduced sample size and related statistical power to detect interactive effects.
Participants in this sub-sample of African Americas were 70% male, the average age was 44 (SD = 10.12) years old, participants had an average of 13.07 (SD = 2.25) years of education, 41.7% were single, 35.2% were married or living together, and 22.2% were divorced or separated. The majority (57.9%) of the sample reported being employed, 27.9% were unemployed at study entry, 8.3% were retired, 3% were disabled, and 2.9% endorsed "other" to employment status. At baseline the mean percent days abstinent was 25.29 (SD = 26.62) and the mean percent heavy drinking days was 66.28 (SD = 29.98).
Mixed model analyses of the effects of naltrexone on percent days abstinent during treatment revealed no significant main effect of naltrexone [t(94) = 0.64, p = .52, B = 2.99, SE = 4.64] after controlling for PDA at baseline [t(94) = 0.74, p = .46, B = 0.06, SE = 0.09], acamprosate [t(94) = 1.95, p = .06, B = 8.93, SE = 4.59], and therapy [t(94) = 0.13, p = .89, B = 0.62, SE = 4.67]. The average PDA for the naltrexone group was 90.1 (SE = 3.32) as compared to the 87.1 (SE = 3.19) for those receiving placebo.
Results of a proportional hazards model revealed no significant main effect of naltrexone for time to the first heavy drinking day in this sample (HR, 1.16; 97.5% CI, 0.63-2.14; p = .59), after controlling for PDA at baseline (HR, 1.00; 97.5% CI, 0.99-1.01; p = .37), acamprosate (HR, 1.28; 97.5% CI, 0.70-2.35; p = .59), and therapy (HR, 1.01; 97.5% CI, 0.55-1.88; p = .96).
Logistic regression analysis of the composite outcome measure (GCO) at the end of treatment revealed no main effect of naltrexone [Odds Ratio (OR) = 1.19; 95% CI = 0.44-3.24; p = .51], after controlling for baseline PDA [OR = 0.99; 95% CI = 0.98-1.02; p = .85], acamprosate [OR = 0.53; 95% CI = 0.19-1.47; p = .11], and therapy [OR = 1.01; 95% CI = 0.37-2.75; p = .99]. Despite the lack of significant naltrexone, acamprosate, or therapy main effects, 75.6% of this sample was classified as having a good clinical outcome at the end of treatment (week 16), suggesting that three quarters of patients benefitted from the treatments provided in the COMBINE Study.
These analyses of the COMBINE Study sought to examine the effects of naltrexone for the treatment of alcoholism among African Americans. Contrary to the reported outcomes for the larger study (Anton et al., 2006), composed primarily of individuals of European Ancestry, the present results did not support the efficacy of naltrexone on percent-days abstinent, time to first heavy drinking day, and global clinical outcome in this subsample of African Americans. Although this sample seemed to benefit from treatment provided during the COMBINE Study, as evidence by marked improvements in drinking pre-post treatment (e.g., 75.6% of patients were classified as having a good clinical outcome at the end of treatment), this study found no support for the benefit of naltrexone in this sample. Of note, the current sample size was powered to detect medium-to-large effect sizes.
Addressing alcoholism treatment in minority populations represents an important goal, particularly in light of the recent pharmacogenetic literature suggesting that the single nucleotide polymorphism (Asn40Asp) of the OPRM1 gene that predicts a more positive clinical response to naltrexone (Anton et al., 2008; Oroszi et al., 2008; Oslin et al., 2003) is very infrequent (< 5%) among individuals of African descent (Arias et al., 2006). These related pharmacogenetic findings suggest that African American individuals may be less likely to benefit from naltrexone, at least through the mechanisms conferred by this specific genetic variant. In the era of personalized medicine, allele frequency imbalance due to ethnicity should be carefully considered (Tate and Goldstein, 2004). Most importantly, these findings should not be interpreted as evidence that all individuals of African descent do not benefit from naltrexone treatment. Instead, these results suggest that further work is needed to test naltrexone in this population and to identify treatment responders via genetics (e.g., polymorphisms in opioid receptor genes, including mu, kappa, and delta receptors) or other psychosocial predictor variables, such as gender, family history, and comorbid psychopathology.
Data presented in this report were collected as part of the multisite COMBINE trial sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in collaboration with the Combine Study Research Group. A full listing of COMBINE study staff can be found at http://www.cscc.unc.edu/combine/.
Role of Funding Source
The COMBINE Study was supported by the National Institute on Alcohol Abuse an Alcoholism (NIAAA) Cooperative agreements U10AA11715, 11716, 11721, 11727, 11756, 11768, 11773, 11776, 11777, 11783, 11787, 11799, and 11773. The first author obtained permission to analyze data for this manuscript directly from NIAAA. The funding agencies had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
The first author (LR) conceptualized the manuscript, undertook the statistical analysis, and wrote the first draft of the manuscript. The second author (DO) contributed to manuscript preparation, particularly the discussion of the findings. Both authors contributed to and have approved the final manuscript.
Conflict of Interest
Both authors declare that they have no conflicts of interest.
Lara A. Ray, University of California Los Angeles Department of Psychology Los Angeles, CA 90095.
David W. Oslin, University of Pennsylvania Geriatric and Addiction Psychiatry Philadelphia, PA 19104.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Beet Greens with Beets
Total Time
Prep 10 mins
Cook 8 mins
When making this dish from your garden or store bought greens, chooose only the young leaves and discard the older, tougher leaves. I like a shake or two of hot pepper flakes.
Ingredients Nutrition
- 10 ounces washed beet greens
- 1 tablespoon butter
- 2 cloves garlic, minced
- 1 teaspoon minced fresh ginger
- 1 lb beets or 1 (16 ounce) cancooked beets, drained and chopped
- 1 lemon, juice of
- salt
- ground black pepper
- In a large pot bring lightly salted water to boil.
- Add the greens and cook to just limp-about 3 minutes.
- Drain well and chop.
- Melt the butter in a skillet, add the garlic, ginger, and greens and saute 1-2 minutes.
- Stir in the chopped beets, lemon juice, and salt and pepper to taste.
- Heat through, about 2 minutes and turn into a serving bowl.
Most Helpful
Di, you are going to think I'm nuts, but this sounded so good, had to try it. Couldn't find any beet greens except some awful looking, with really old big leaves, soooo, I used some lovely nice fresh spinach! with canned baby beets. It turned out delicious!! the garlic, ginger and lemon are a great combination, I can hardly wait for spring to try it with nice fresh beets with young beet greens. Thanks for sharing, beets are one of our favourite veggies and we will enjoy this recipe often.
Absolutely awesome and I even forgot the lemon. I have had this recipe in my cookbook since December and have been anxiously awaiting the first fresh beets at the farmer's market. This was well worth the wait.
Really good. I had a HUGE bunch of fresh beets from the grocery store and wanted a way to cook the tops as well as the roots. The way the recipe is written, the root part doesn't get cooked much at all (perhaps it's written for canned beets) so I boiled my cubed beet roots until they were soft and then added them to the sauteed greens. We loved 'em, thanks for the recipe!