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As season grows old, Ravens need to start thinking young
There are 50 comments on the Baltimore Sun story from Nov 27, 2007, titled As season grows old, Ravens need to start thinking young. In it, Baltimore Sun reports that:About a week ago, Ravens coach Brian Billick was saying all the right things. He still talked about the playoffs and having enough confidence to win the remaining six games.
Join the discussion below, or Read more at Baltimore Sun.
#1 Nov 27, 2007
Mark Clayton has great elusiveness? What games are you watching? You must mean the former Miami Dolphin because the Raven Mark Clayton gets zero separation and is lucky to get 2 yards after a catch.
#2 Nov 27, 2007
Mike don't you think that the fire is gone? Several of those players you may be considering replacing if on a team with a game plan would probably look a whole lot better, if sure they would feel a whole lot better and would have a lot more fun then they are now.
I know this a business but it's also a sport and sports are still supposed to be fun for the fans and most importantly the players, neither of which have been having any fun for quite some time.
Look around the league and you see the teams that are winning have players on a level (with the exception of a quarterback) with our own. The coaching staff properly prepair their team for the following Sunday and are knowledgable enough to make corrections during a game when required so those players look like they know what to expect and how to deal with it.
Baltimore has those players they don't have those coaches.
You are an excellent sports writer Mike but on this one I don't agree with your assessment.
#3 Nov 27, 2007
On the money again with this article - Ravens need a youth movement in the WORST kind of way. With all due respect to the grizzled vets who have played their hearts out for B-more, it's time to start thinking about next year and finding out who deserves to stick around.
#4 Nov 27, 2007
For once I agree with DePreston except about Troy Smith. TOO SMALL.
I would put all the injured players on IR, sit most of the veterans that have a player behind them on the depth chart and wing it! Sounds a little like the Orioles doesn't it?
I hope MD basketball is worth watching this year becasue there sure as hell ain't gonna be anything else.
#5 Nov 27, 2007
I was thinking about people like Matt Bouza, Ray Butler, Curtis Dickey, Randy McMillan, Tim Sherwin, Art Schlichter, David Humm and Mike Pagel and it seemed to me that the Raven's concerns weren't so bad. Who were those guys? They were the alleged skill players for the 82 Colts. Ravens fans have really shown how entitled they are this season. As someone who witnessed the Mayflower massacre, it could be a lot worse.
#6 Nov 27, 2007
"Billick might also make similar moves on the offensive line, inserting some of these youngsters at times for left tackle Jonathan Ogden and center Mike Flynn."
He already did that which is why the O-line has had such a bad year. Since when does winning the Heisman trophy mean you deserve anything in the pros? Go down the list and see how many busts it includes.
#7 Nov 27, 2007
Maybe the Ravens can cover the spread ala Miami and Philly
#8 Nov 27, 2007
You're right about Smith! Just not tall enough to see the field in the NFL. On Terps, I suggest you take the leap to the women's team, the guys are just too raw and shallow this year. Beyond Gist, Osby and Vasquez, their just too inexperienced.
United States
#9 Nov 27, 2007
You cannot win in this league with an offensive line that has two first year players and two second year players starting. It makes little difference who is your QB.
Since: Nov 07
#10 Nov 27, 2007
You think Billick was saying the right things last week by suggesting the Ravens could win their remaining six games? Preston -- you're not only a lousy writer, you're as insane as Billick is.
#11 Nov 27, 2007
Some good suggestions Mike, but Billick will not do it. He will stick with the status quo and since Biscotti loves him so much, he will be here next year and it will all be the same. Billick will NOT change!, so don't try to make sense.
#12 Nov 27, 2007
I thought that's what the Ravens have been doing all year with all the injuries. The O line is the problem. When Boller has time,he hits his target.
United States
#13 Nov 27, 2007
Since you cannot (by law) libel the dead, I guess its safe to say the Ravens SUCK!
I think many problems on offense can be laid right at the feet (clodhoppers) of the offensive line. Ogden is not the player he was even a year ago, and none of the replacements appear to be any better. Tom Brady and Peyton Manning would look as bad as Boller and McNair behind these guys. I think Steve Biscotti should open his wallet and make offers to Joe Bugel of the Redskins and Dante Scarnecchia of the Patriots to coach the Ravens offensive line. I dont believe Ozzie Newsome is that bad at drafting an offensive line. But what are Chris Foerster, Wade Harmon and Greg Roman doing with that talent? Not much, it appears.
The Ravens will probably say goodbye to many older players, just like its been rumored. Im pretty sure Ogden and Flynn will go, as well as Ray Lewis, whos slowed down considerably in 12 years, Derrick Mason and Mike Anderson. If they choose to keep Figures, then the trainer needs to liberally spray glue to his hands.
Thanks for letting me vent.
#14 Nov 27, 2007
Are you kidding me! You may be right about looking at the roster for the future, but with this coaching staff, a roster of former college all stars would still have to contend with a bland no imagination game plan to try to score a touchdown. The only reality is the record over seven years.No imagination on offense. The defense cannot carry the offense.
Ottawa, Canada
#15 Nov 27, 2007
Well Mike you have a supreme grasp of the obvious. The season is over and the Ravens need to get young. I'm not as positive about our young offensive line as maybe you are, but at least considering we always had 1 pro bowler and 4 also ran's I guess we'll make do.
I'd like to be suprised by troy smith at quarterback, but don't think I will be. More importantly, everyone is making Mcgahee out to be some stud running back and I don't see it. We let our best offensive player of the billick era leave last year and for what? I know so we could re-invent the offense! HA HA!
As for the receivers, we don't have any other than mason that's why he gets all the passes! I'm sure some of that falls on the scheme and the quarterback, but I'm sure derek anderson wouldn't look as good throwing to spyniewski and williams as he does throwing to braylon edwards and winslow. As much as I fault billick for this offense, I don't believe we've ever had talent at the skill positions other than Jamal and that's Ozzie's problem. Yes, heap's great for the 40% he plays but who can rely on that.
Blow it all up! HIRE BILL COWHER AND GO BACK TO OLD SCHOOL FOOTBALL!
#16 Nov 27, 2007
No kidding, but what do we do about Billick.
#17 Nov 27, 2007
Ya'll some racist bltches.
#18 Nov 27, 2007
I am one of those who blames Ozzie Newsom as well as Billick for the lack of talent on the Ravens. Put aside the defensive players drafted by Phil Savage, the team doesn't have any real stars. When you draft busts like Devard Darling and Pittman in the third round your scouting department and talent evaluation processes have failed. The Ravens need to look in-depth at their scouting department.
#19 Nov 27, 2007
Man...them Ratbirds are looking pretty old. Someone get Ray Ray a can of Ensure. Maybe your team should buy stock in Geratol and Ben Gay as well.
P.S. Please sign Billick to a lifetime contract.
#20 Nov 27, 2007
If Ogden retires and Flynn moves on; I'm not sure Chester is more than a backup; so, (Unless they draft Jake Long) I see :Terry at LT, Grubbs at LG, Brown at C, Yanda at RG, and Gaither at RT. I'm not too worried about LB but Help at CB and QB is needed and this was supposed to be a TE heavy offense and thier is only one who can play.
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Re: Monitor calibration for print output
In reply to Hugowolf • Feb 20, 2013
Regarding to calibrating/profiling screens, the following article explains why it's almost always better to profile at D65 than D50:
This conclusion has to do with the sensory and cognitive mechanisms which are used differently for print and monitor viewing. Chromatic adaption is not fully achieved by human vision looking at a bright screen at D50. This is not the case of D65, but someone should not compare print and monitor side-by-side. The observer would have to have time to fully adapt to each separately.
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You'd be hard pressed to find a better description for the Alliance Theatre's Kenny Leon. "Outgoing" in every sense of the word, Leon's departure as artistic director leaves Atlanta's most prominent playhouse energized and transformed after more than a decade of service.
Perhaps Leon's most characteristic qualities can be found not in any single production but in the ritual of his opening night curtain speeches. Every time he'd bounce on his trademark tennis shoes, the house lights gleaming on his bald head, and crack a smile that seemed nearly as big as the stage behind him. With palpable excitement, he'd top off the necessary "welcomes" and "thank yous" by saying something like, "The space here, between the audience and the actors, is where the magic happens." And he'd say it with such sincerity and passion that even the most cynical skeptic would believe him 100 percent.
Leon has already given his last curtain speech as artistic director, but fans and theatergoers can see him once more as he performs in the final production of the 2000-01 season in Yasmina Reza's comedy Art. A light and nimble French hit about friendship and artistic expression, Art is Leon's dessert, the cherry on top of his tenure with the Alliance. Fittingly his co-stars, Tom Key and Chris Kayser, have long, close relationships with the theater, and Art will be directed by Leon's associate artistic director, David H. Bell.
Assessing Leon's 11 years at the Alliance, his greatest role may have come not from any one show, or even in providing the theater's creative vision, but as an advocate and ambassador for drama itself. With Leon as a face, a voice and a cheerleader for theater, he helped tear down its cobwebbed image as an art form solely for the elites, even in as grand and immaculate a venue as the Woodruff Arts Center.
In the 1990s the Alliance became much more popular with African-Americans, and Leon proudly points to how black audiences went from being 1 percent-2 percent of the subscriber base to more than 20 percent. Leon's signatures include his productions of works by August Wilson, which predate his time as artistic director: He helmed Joe Turner's Come and Gone in 1989 and Fences in 1990, which proved the Alliance's most successful play that year.
Wilson is one of the indispensable American playwrights of our time, yet Leon didn't stop with simply staging all of his plays. He also revived lesser-known works by black writers, like James Baldwin's The Amen Corner. Two productions that may best represent the inclusiveness of the Kenny years weren't even directed by Leon, but by Bell: the multicultural musicals The Boys From Syracuse and Hot Mikado.
Leon leaves the Alliance as a major figure in America's regional theater. When Walt Disney Theatrical Productions selected the Alliance for the premiere of the Elton John/Tim Rice musical Elaborate Lives: The Legend of Aida in 1998, executive vice president Tom Schumacher said, "We did a national survey of regional theater and found that all roads lead to Atlanta -- not so much for the facility as for Kenny Leon and the audience he's cultivated for new work."
In retrospect, it's amusing that the Alliance board of directors' decision to name Leon artistic director 11 years ago was seen as a gamble at the time. A graduate of Clark College in the 1970s, Leon had worked his way up through the ranks of Atlanta playhouses, with relatively little experience outside the city and no administrative background when he was tapped at the age of 34. His first year as artistic director, 1990, reflects a changing of the guard for Atlanta theater. Not only did Leon come on board at the Alliance, but the Academy Theatre, then the city's oldest resident playhouse, closed its doors.
Leon made a provocative statement with his first production as artistic director, presenting the scorchingly effective drama Miss Evers' Boys. The show included explosive subject matter for the Alliance -- a government experiment that withheld treatment for four African-Americans suffering from syphilis -- as well as a major performance by Leon's then-wife Carol Mitchell-Leon and entertaining support from Leon's Art co-star Kayser. The production received a rave review in Time magazine.
Still, in the 1990s the Alliance frequently reflected the conservative tastes of the Atlanta audience, rarely straying far from the theatrical mainstream. Shows like Angels in America and How I Learned to Drive provided undeniably daring material, but also came with the validation of Pulitzer Prizes and prior commercial success. For every daring show, you can find several "safe" chestnuts: The 1996-97 season included To Kill a Mockingbird, Romeo and Juliet and Sleuth at the Alliance Studio. Of course, immortal plays stay classics for good reason, and the 1996-97 year also saw Leon's stellar work with The Glass Menagerie, another highlight of the decade.
Still, shows like Regina Taylor's The Ties That Bind in 1995 (with its unnerving, mind-blowing mixtures of cultural stereotypes) tended to be exceptions rather than rules. The new plays cultivated by the Alliance in the 1990s, such as Alfred Uhry's Last Night of Ballyhoo and Pearl Cleage's Blues for an Alabama Sky, are more likely to be labeled well-made choices rather than risky ones. And Debbie Allen's Soul Possessed and the Disney Aida musical can seem overly calculated as Broadway wannabes. Credit Aida, though, for providing royalties to be used to retire the theater's debt. And while the theater's fiscal health may not have been Leon's direct responsibility, like the U.S. president and the economy, he gets credit (or the blame) for what happens on his watch.
One of the proudest feathers in Leon's cap is Playland by South Africa's legendary playwright Athol Fugard, which in 1992 shared its U.S. debut with the Alliance and the La Jolla Playhouse, and speaks to the theme of racial common ground. And in 1998, Fugard's play The Blood Knot would provide arguably Leon's finest performance as an actor, in a Theatrical Outfit production opposite Key and directed by Bell.
After Art Leon will be gone but never forgotten. For that matter, he won't exactly be gone; he returns to the Alliance in May 2002 to direct the musical The Wiz, which may prove to be either an eccentric whim or a revelation of a show overdue for revival. Ironically, the theater's 2001-2002 season features some of Leon's most eclectic selections in years.
Leon steps down as an artist who helped reveal to Atlanta a vision for its own creative identity. The 1996 Olympic mascot Whatizzit, however reviled, was not inappropriate, as Atlanta has always had trouble defining itself artistically, more confident about what it doesn't want to be than what it is. But by building bridges between communities and bringing vitality and resources to plays old and new, Kenny Leon showed Atlanta a route to enrich its social and cultural life.
And that's not a bad magic trick.
Art plays May 10-June 10 at the Alliance Theatre, Woodruff Arts Center, 1280 Peachtree St., with performances at 8 p.m. Tues.-Fri., 2:30 and 8 p.m. Sat. and 2:30 and 7:30 p.m. Sun. $16-45. 404-733-5000.
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Apparently 140 Characters Is Enough
How do you sum up your day in 140 characters on Twitter? At the 140 Character Conference in New York Tuesday and Wednesday, live, ten-minute speakers spread out from 8 a.m. to 6 p.m. Luckily, there were no mentions of what anyone was eating or how much someone loves Justin Bieber.
Everything Twitter was discussed. Tweeps live-tweeted and live-chatted. Action was live-streamed. It was intense. Who typed the most interesting quotes the fastest? Who paraphrased the current speaker in Tweetable length..., while including the #140conf hash tag? On the twitterverse, the conference became a top trending topic. Twitter was continuously "over capacity."
It all began with a welcome from Miss America 2010 Caressa Cameron and conference creator Jeff Keni Pulver, before jumping into talks with NYU professors and CEOs. Jeffrey Hayzlett, CMO of Kodak, welled up viewers via new social media campaigns showing how a tweet is sort of like a Kodak moment. Aww.
But the speaker who really stood out during the two-day event was Chris Weingarten. A self-proclaimed "last rock critic standing," the freelance writer for Rolling Stone, Spin, Revolver, and Village Voice, among others, was straight, to the point, and funny. He compared music to math and even claimed the advent of the Internet was killing his job. Most of his monologue dealt with bashing the Hype Machine. My favorite idea: "Good writing dies at the hands of search engine optimization." He even compared listening to new music to "playing Mad Libs with Google trends." The Internet has bands becoming "Internet hustlers."
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His Twitter handle @1000TimesYes became a trending topic at one point. Tons of soccer moms and conservatives chatted beside the live stream concerning how "crude" his language was. Some even counted how much he cursed.
On the live stream, the number of viewers was displayed at the bottom of the screen. It increased from the hundreds to the thousands as he spoke. Weingarten created a meme blog (hipsterpuppies.tumblr.com) and now has a book deal in the works for it, maybe to offset all of his inner music rage with cute puppies.
His full speech is now online, or stream the entire 140 Character Conference.
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PRACTICAL TRAVELER; Who's Afraid of Consolidators?
Published: April 12, 1998
(Page 2 of 2)
A new organization just for consolidators, the United States Air Consolidators Association, has 11 members. According to the organization, to be a member, a consolidator must have transactions of at least $10 million annually with scheduled airlines -- meaning they are prime consolidators -- must have been incorporated in the United States for at least two years, and can never have filed for bankruptcy or ceased operations.
The members and their addresses are available on the Web at www. usaca.com, or can be obtained by mail from the organization at 925 L Street, Suite 220, Sacramento, Calif. 95814; (916) 441-4166, fax (916) 441-3520.
The other organization is the United States Tour Operators Association, whose name explains its membership. Many tour operators run consolidator businesses on the side. Among other standards to insure stability, this organization requires members to have a security deposit of $1 million to repay clients in the event of a default. About 10 major consolidators are among the 56 members of this group, which do business under 143 names.
The tour operators' group is larger than it has ever been. Robert E. Whitley, president, attributes this growth to anxiety among travel agents and consumers about the stability of tour companies, as well as the impact of a California law regulating sellers of travel. Right now times are so good for operators, Mr. Whitley said, that there have not been the conspicuous defaults of a few years ago. But, he said, calls to his organization indicate continued concern. Members of this group are listed on its Web site, www.ustoa. com. A list is also available by mail from the organization, at 342 Madison Avenue, Suite 1522, New York, N.Y. 10173; (212) 599-6599.
Members of the tour operators' association that have divisions selling consolidator tickets are:
African Travel, (800) 421-8907.
Central Holidays, (800) 935-5000.
Freegate Tourism, (800) 223-0304.
Homeric Tours and Charters, (800) 223-5570.
J & O Air, (800) 877-8111.
Jetset, (800) 638-3273.
Sunnyland Tours (800) 783-7839.
Magazine Lists the Fares
Another important change is the availability to consumers of Jax Fax, a ''travel marketing magazine'' that formerly confined its circulation to travel agents. This catalogue-like magazine is published monthly. It went onto the Web about a year ago, and at the same time began offering subscriptions to the public for $30 a year. Travel agents pay $15.
The hot stuff in the magazine is hundreds of single-line listings of fares to places all over the world, organized by destination and origin. These are all ads, placed by the consolidators. Usually they are net fares, meaning that the agents who sell them must add commissions before quoting the price. When these companies sell directly to the public, they will probably add the equivalent of a commission. A directory of the listing companies provides addresses and telephone numbers and notes whether a company belongs to the tour operators' or the consolidators' group. Some companies sell only to travel agencies -- for example, C. L. Thomson-Thrifty Air, one of the biggest.
Its Web site, www.jaxfax.com, has a subscription form. The magazine is at 397 Post Road, Post Office Box 4013, Darien, Conn. 06820. The Web site gives a taste of the magazine, permitting a traveler to enter a destination and an originating city or airport code to get a price, but it is not possible to scan the entries.
It is illegal in New York State to put on a surcharge for use of a credit card. But most law-enforcement agencies, Ms. Brown said, have bowed to a circumvention of this: many consolidators provide a discount for those paying cash. The word from here: that kind of saving is not worth it. Pay the two bucks and use a credit card.
Drawing (Stuart Goldenberg)


text:
Utah Utes men's basketball notebook: Utes unable to shut down Pac-12 leading scorer Allen Crabbe
Rick Bowmer, ASSOCIATED PRESS
SALT LAKE CITY — Utah's defense went for the trifecta Thursday night. The bid, though, fell by the wayside as California's Allen Crabbe did what those next to him on the Pac-12's overall scoring list (Washington State's Brock Motum and Washington's C.J. Wilcox) couldn't do against the Utes — put points on the board in the first half.
After missing his first three shots from the field, Crabbe nailed a 3-pointer with 10:23 remaining in the first half. It gave the Bears the lead for good — at 14-11 — and started a run of eight straight points for the Pac-12's leading scorer. He finished with 23.
"I thought Crabbe played really well for them tonight," said Utah coach Larry Krystkowiak. "We were just not as locked in defensively as we have been the last few games."
Cal coach Mike Montgomery acknowledged that Crabbe was a tough matchup for the Utes.
"They went to a box-and-1 for a while and we got a little stagnant but Allen made some tough shots," Montgomery said.
Utah senior Cedric Martin, who drew the early assignment on Crabbe, blamed himself for the lack of effective pressure on Crabbe.
"I, myself, didn't lock into what the coaches told me on how to play Crabbe on defense," Martin said. "So I'll take his 20-something point game on me."
POWER OF PINK: In support of the Huntsman Cancer Institute and cancer awareness, the Utes sported uniforms, warm-ups and shoes trimmed with pink. Fans were also encouraged to wear the color. In addition, pink "thunder sticks" were handed out at the turnstiles.
MEETINGS PLANNED: Sophomore center Dallin Bachynski logged only three minutes of playing time. Krystkowiak said he plans to meet with him Friday morning, noting such things as energy, composure and staying locked in.
"We'll take that up together. It's not perfect for a lot of guys. It wasn't supposed to be easy for anybody. There's a lot of challenges and it's important that guys come in with the right mindset," Krytskowiak said. "I think that's the area that we're struggling with right now — is making sure that we've got everybody on board. I'm not sure Dallin's a little more worried (about) his trials and tribulations than he is about what the University of Utah is going through. That ends up being dysfunctional."
Krystkowiak added that he's also going to meet with senior guard Jarred DuBois, who missed a couple of days of practice this week with an undisclosed injury. DuBois didn't play in the first half and saw nine minutes of time in the second, scoring three points.
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Minolta DiMAGE E323 review
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Luds • New Member • Posts: 6
Minolta DiMAGE E323 review
Mar 21, 2004 • Review of Minolta DiMAGE E323
Quick start, small dimension, only 2 AA bateries and very long time to use, pictures have good quality.
Be missing Panorama modus and PanoramaSW, flash seems to be too powerfull, faces are a little overexposed (too white), Movie modus without sound.
3 megapixels • 1.6″ screen • 36 – 108 mm (3×)
Announced: Aug 7, 2003
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text: Emcore Content on this page requires a newer version of Adobe Flash Player. Emcore ( EMKR) is a provider of compound semiconductor-based components and subsystems for the broadband, fiber optic, satellite and terrestrial solar power markets. This stock is trading up 8.1% to $5.05 in recent trading. Today's Range: $4.59-$5.08 52-Week Range: $3.45-$5.99 Volume: 125,000 Three-Month Average Volume: 100,249 From a technical perspective, EMKR is ripping higher here right off its 200-day moving average of $4.62 with above-average volume. This stock has been uptrending strongly for the last two months, with shares soaring from its low of $3.91 to its intraday high of $5.06. During that move, shares of EMKR have been consistently making higher lows and higher highs, which is bullish technical price action. This move today has now pushed EMKR into breakout territory, since the stock has taken out some near-term overhead resistance levels at $4.85 to $4.96. Traders should now look for long-biased trades in EMKR as long as it's trending above $4.50, and then once it sustains a move or close above those breakout levels with volume that hits near or above 100,249 shares. If EMKR can maintain this move, then this stock will set up to re-test or possibly take out its next major overhead resistance levels at $5.87 to $5.99. Any high-volume move above those levels will then put $7 into range for shares of EMKR. Prev 2 of 4 Next


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About the Authors
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Corresponding Author
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ERR JBC. Performed the experiments: ERR MBF DEC GZR JRP JM CTDS JCM POP DG RMM AGO TMA HFC. Analyzed the data: ERR DEC LAV MJS JBC. Wrote the paper: ERR JBC.


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Acrylic - Clear
0.060 inches 0.080 inches 0.118 inches 0.177 inches 0.220 inches 0.354 inches
What is it
Acrylic (PMMA) is a thermoplastic that is available in a wide range of colors including transparent tints and clear to opaque solid colors.
How fast will this material ship?Orders using this material will ship as fast as same day. Find out more.
Can I get a sample?You can get a sample here.
Design NotesAcrylic is hard and stiff as plastics go. It is sensitive to stress concentrations sharing a certain fragility with glass. This is most evident if parts are small or thin. Details should not be smaller than 1mm/0.04" as they are likely to be too fragile.
The manufacturers tolerance for the thickness of the materials is as follows:
|Material thickness
|Possible Range
|0.060" / 1.5mm
|0.032" - 0.083"
|0.8 - 2.1mm
|0.080" / 2.0mm
|0.051" - 0.100"
|1.3 - 2.5mm
|0.118" / 3.0mm
|0.088" - 0.138"
|2.2 - 3.5mm
|0.177" / 4.5mm
|0.139" - 0.199"
|3.5 - 5.1mm
|0.236" / 6.0mm
|0.191" - 0.261"
|4.8 - 6.6mm
|0.354" / 9.0mm
|0.294" - 0.384"
|7.4 - 9.8mm
Engraving AcrylicThere are 3 types of engraving possible with laser cutting. Area engraving, line engraving and a combination of both.
Area engraving is great it you need to mark a large area on the surface of the material. To specify area engraving set your shapes to have a fill color of black with RGB values of 0, 0, 0. The way this engraving is performed is like an old dot matrix printer except instead of dots of ink it uses pulses of the laser beam. This is a surface finish not deep enough to be used for pocketing or inlays. The depth of the engraving ranges between 0.1-0.5mm.
Line engraving is like a really shallow cut. To achieve this effect the stroke color to red with RGB values of 255, 0, 0 and set the stroke style to a width of 0.01 mm. The laser beam follows along the red lines that you have in your design and marks the surface of the material. The result is crisp but it can be a time consuming technique if you have a lot of small details like text.
Using a combination of both engraving types typically gets the best result. Set your shapes to have a fill color of black with RGB values of 0, 0, 0, the stroke color to red with RGB values of 255, 0, 0, and set the stroke style to a width of 0.01 mm. The line engraving causes the laser beam to trace around the edges of the engraved areas making them more crisp and bringing the details to life.
Construction TechniquesCreating structures from acrylic can be tricky due to variations in the material thickness. Creating a design that can accommodate variations in the material thickness is the best way to go.
For some tips on how to design for acrylic see this post.
Additionally the laser cuts at a slight taper (1-2 degrees) since the laser beam is shaped like a cone. The tapering causes one side to be slightly smaller than the other side. The taper is almost unnoticeable in 1/8" material; the thicker the material, the more noticeable the taper. When using laser-cut parts such as wheels or gears, you might need to position the parts in an alternating pattern so that the tapers "cancel out".
Typical UsesAcrylic is commonly used for making jewelry, tableware, electronics enclosures, conference badges, signage, book covers, point of sale displays etc
Environmental InformationAcrylic is non toxic and recyclable in some areas.
Adhesives, joints and fasteningsAcrylic can be joined with epoxy, Weldon 3, 16 and 40. Dichloromethane and chloroform. Screw joints should be pre-drilled to avoid splitting.
Tips from other designers
Curious how flexible the thinnest acrylic you offer is, the 1.5mm sheet. If i get the P3 size (approx 31 inches by 15 inches), and you held it up by the center, how much sag would there be on the longer dimension at the ends? I am trying to recreate an acoustic lens and need thinness and rigidity (not so much strength) where originally metal sheets were used.
The 1.5mm acrylic sags by ~2 inches at each end when held as you described.
Do the custom acrylic parts come with finished edges like the sample piece does, or do customers have to finish the edges once the piece is delivered?
The images and samples show how the material comes off the laser cutter, without any additional finishing. With acrylic the finish is similar to flame polishing.
Does the acrylic become more opaque when etched? I'm guessing from the shadows it does, but any chance of a photo of the ponoko logo behind an etched piece?
@barry - yes the acrylic gets a kind of frosted appearance where the etching is performed. It's best to order a sample or make a prototype on a P1 to see how the engraving will come out in real life. Trying to capture the subtleties in a photograph is quite difficult :(
I'm helping my son with a project from the Making Things Move: DIY Mechanisms for Inventors, Hobbyists, and Artists by Dustyn Roberts. Her book pointed us to this site to buy a sheet of 1/4 inch thick clear acrylic approximately 15 X 31, but I don't see an option for ordering 1/4 inch thick. Can someone tell me how to order that here - I'm new to this site. Thanks!
You can read how to do that here - http://support.ponoko.com/entries/498894
that 15% is only for variance from overall thickness requested right? meaning i wont get a sheet that is 2.7mm on one end and 3.3 on other?
@justice There can be some variation within a sheet but it is usually not at each extreme. Generally I'd say it could range 0.2-0.3 within a sheet.
Is clear acrylic etched from the back as mirror acrylic?
Hi Kiandra- The mirror acrylic is the only material that we engrave from the back. The clear acrylic here is the same on both sides, so until we make your design there isn't really a front or a back. Hope that helps!
Will there be a lot of light distortion if I were to sandwich two peices of acrylic together or would it look like looking through a single piece of acrylic?
Hi Trang - Assuming the pieces are just sandwiched (rather than glued) the light distortion should be minimal - about the same as looking through a single piece.
Does the finished piece have a protective coating that needs to be peeled off? Wondering if I can fill the engraved portion with paint and then peel off the covering?
Hi Shannon,
1.5mm and 2mm comes with a plastic or paper protective layer/tape and the rest of the thicknesses all have a layer of protective paper tape. You should be be able to use this protective tape to help paint your parts, like in this article - http://www.instructables.com/id/Improving-Laser-Etched-Acrylic-Panels-with-Acrylic/
Use black fills for area engraving and red strokes for vector line engraving.
I'm intending to have an interface design engraved on the clear acrylic, which I will then bend into a visor shape (using a heat gun if need be) and edge light with small LEDs as part of a costume. What thickness would you recommend for this application? I'm torn between 1.5mm, 2mm and 3mm. Thanks!
Hi Kira -
We have had the best luck with 3mm clear when creating eyewear & visors. You can get a nice, broad bend & the end product will be sturdier than 1.5mm, which will be helpful if the glasses fall while you're wearing the costume.
I hope that helps for starters.
Don't hesitate to get in touch if you have any other questions, or things we can assist with.
- Dan


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Matt Steichen
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Matt Steichen has been the sports editor at the Farmington Independent and Rosemount Town Pages since 2007. He holds a bachelor's degree in journalism and mass communications from Briar Cliff University in Sioux City, Iowa. He has previously been a sports writer at the Sioux City Journal and Le Mars Daily Sentinel and the sports editor at the Austin Daily Herald.
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Chanhassen won four of the final five events to separate from Farmington in an eventual 98-88 Missota Conference dual meet loss Thursday night at Dodge Middle School. The score was tied at 0-0, 31-31, 39-39 and 55-55 before the visitors used a victory in the 500 freestyle to move ahead by two points.
In last week's season opener, Farmington played well in the first half before a poor second half resulted in a seven-point road loss to Rochester Mayo. The Tigers continued their inconsistent play Friday night, falling behind 19-0 at Red Wing in an eventual 27-19 Missota Conference road setback. It was Farmington's first loss to Red Wing since October of 2004. "Part of the issue is we have a lot of young, first-year players," Farmington head coach Mark Froehling said about his team's inconsistent play.
Farmington's fundamentals failed in its first loss of the season Monday night at Bloomington Kennedy. The Tigers allowed four second-half goals and fell from the ranks of the undefeated with a 6-1 loss to an Eagles team that entered play with a record of 3-3. "We certainly handed them the win this afternoon. They had us on our heels the whole game," Farmington coach Julian Buss said. "We didn't do the basic things that you have to do at this level to be successful.
In last week's season opener, Farmington played well in the first half before a poor second half resulted in a seven-point road loss to Rochester Mayo. The Tigers continued their inconsistent play Friday night, falling behind 19-0 at Red Wing in an eventual 27-19 Missota Conference road setback. It was Farmington's first loss to Red Wing since October of 2004.
The Farmington boys soccer team finally allowed a goal Thursday night, but it didn't stop the Tigers from grabbing another win and continuing the best start to a season in program history. Goalkeeper Chad Stivers allowed his first goal of 2011 with nine minutes remaining, but stopped a late barrage of Rosemount shots as he finished with 15 saves and preserved a 2-1 win over the Irish at Tiger Stadium. "Chad Stivers had a tremendous night," Farmington coach Julian Buss said.
Megan Stivers accounted for Farmington's lone win in last Thursday's 6-1 loss at Simley. Stivers, a sophomore, used a strong finish to hold on for a 7-5, 4-6 (7-5) decision at No. 4 singles. The only other match to go to a third set was No. 3 singles, where junior Melanie Kappes lost 3-6, 6-2 (7-1). "Melanie and Megan were their usual tenacious selves, taking their opponents to the third set tiebreaker," Farmington coach Jack Olwell said. "Melanie's opponent picked up her play significantly in the second set and tiebreaker." Olwell also credited No.
The Farmington girls swimming and diving team had no trouble gliding by Red Wing in its Missota Conference season opener last Tuesday. Led by Kaitlyn O'Reilly's four first-place finishes, the Tigers won nine of the meet's 12 events in a 90-88 victory in Red Wing. The visitors led 90-50 after nine events, causing the last three events to be swum as exhibitions. "Red Wing was a good meet for us," Farmington coach Jen Marshall said.
After opening the season with back-to-back wins over Big Nine Conference teams Albert Lea and Austin, the Farmington volleyball team got a chance to measure itself against a stronger opponent Thursday in Rosemount. The Tigers were blown out 25-8 in Game 1, but improved throughout the final two games as they bowed out 25-21, 25-16 for their first loss of the season at Irish Gym. "The difference was completely defense. Rosemount is such a good defensive team, they make it tough to score points and that can be frustrating," Farmington coach Mike Woody said.
Farmington finished seventh in alum Lisa Lippold's debut as head coach Friday at the Dakota County Invitational in Eagan. Lakeville South won the nine-team meet, beating runner-up Eastview, 60-74. Eagan (91), Hill-Murray (103), New Prague (116) and Hastings (126) finished ahead of the Tigers, who scored 166 points. Sophomore Dan Block led the way for the Orange and Black, placing 23rd out of 77 runners with a 3,200-meter time of 11 minutes, 29 seconds.
Participation numbers for fall sports at Farmington High School are similar to last year's and continue to trend upwards over the last seven years, according to data recently compiled by athletics director Jon Summer. A total of 964 athletes are competing for the Tigers this fall in grades 7 through 12, up from 947 a year ago and an average of 866 over the last seven years. The sports with the biggest jump in participation this fall is cross country, with 16 more boys and seven more girls competing for the Tigers.


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News By Tag
* Northwestern Mutual
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Lack of financial planning leaves aging women unprepared
Women are aware of long-term care options, but not planning accordingly
Findings revealed women have a better understanding than men about the resources and options available to individuals facing a long-term care event; however, they're significantly less likely to take action to protect themselves from the risks.
"There are two reasons long-term care should be top-of-mind for women: traditionally they're the caregivers in their families, and they face greater longevity," said Mike Condrey, managing partner of the Carolina Condrey Group located in Raleigh. "The best way they can translate their concerns into actions is by talking to an experienced financial representative who can help determine a course of action."
The findings come from a two-part study by Northwestern Mutual and were released in conjunction with November's Long-Term Care Awareness Month. They indicate:
• 73 percent of women are aware of at least one of the long-term care options available to them
• 4 in 5 women (80 percent) are sure of what they would need assistance with/don't think they would need assistance in the case of a long-term care event
• 4 in 5 women (79 percent) were able to estimate how long – on average – they might need long term care
Long-term care refers to services that individuals who are chronically ill or suffering from a disabling condition or cognitive impairment rely upon. In 2011, the average daily cost of a nursing home in Raleigh, North Carolina was $216/day, the monthly cost for assisted living was $3,164, and the hourly average for a home healthcare nurse was $18/hour.
In Charlotte, North Carolina, the average daily cost of a nursing home was $228/day, the monthly cost for assisting living was $4,241, and the hourly average for a home healthcare nurse was $19/hour.2 Raleigh was slightly below state averages, while Charlotte was slightly above.
Women aren't taking action
In contrast to their recognition of the risks, 30 percent of U.S. female adults said they're not sure how they plan to address their potential long-term care needs, while 57 percent of women reported they're likely to need help meeting financial expenses.
Furthermore, only 37 percent of women said they're saving for their future needs, and are significantly less likely to own long-term care insurance than their male counterparts (9 percent vs. 15 percent).
Additional Resources for Long-Term Planning
Northwestern Mutual has a range of resources to help individuals think about and plan for their long-term care needs:
• Use the Lifespan Calculator to consider how long you may need your money to last.
• Visit the Long-Term Care Cost Calculator to better understand the potential cost of long-term care services.
• Learn more about the long-term care costs and options available to you.
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"The holiday cards were phenomenal ! Design services were beyond professional and streamlined the design to perfection. I just adore these cards!!!"
"We send photo Christmas cards to close family and friends. I am a mom with two daughters and have done a variety of themes. This year is perfect! We vacationed in Costa Rica and have amazing photos to share. The Feliz Navidad card is perfect. It's not Halloween yet and I'm ready to send them out. Thank you for your wide selection and beautiful designs! It is worth the extra price to me over what Costco or CVS have to offer."


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This replica rolex Yacht-Master is designed for the yacht race, but, the original replica rolex Yacht-Master without the special function of timing, just through the rotating watch bezel to manual timing and this is the rolex yachtmaster replica. Rolex launched this series watches in 1992, then imported the special materials of platinum bezel, dial plate, steel watchcase, watchband, and watch-head.
At present, this replica rolex Yacht-Master match with the modeen technology and published in 2012 Basel watch Fair, the official number is 116622, this watch with blue dial plate and the price is about 95800, there are a similar model, and the official number is 16623, this watch with gold dial plate, gold wtch bezel, between-gold watchband and the price is about 92500.
This replica rolex Yacht-Master including almost all the iconic design elements of rolex brand, the watch band decorated with triangular grooved lines, bothway rotating three-dimensional mark, polished Arabic numerals sign, the rest for matte frosted, a simple technology on the metal dial plate that added a ray of steady mental aura.
The watch-head with a raised device, also with triplock triple cochain watch-head, rolex launched this watch-head technology in 1970, and there are many series with this device, such as replica rolex submariner, replica rolex Deep-Sea and so on. The watch bezel, watch bottom and watch-head was tightly screwed in the middle watch case, this si the famous oyster watchcase technology, the water resistant to 100m of this replica rolex Yacht-Master, with three-piece links watchband.
The deep blue dial plate with great metallic lustre, the dial plate with a goldfish-eye glass convex mirror and this is another mark of rolex replica, big dot shape of time scale. The shapr of hour hand and minute hand is very unique, the second hand is red, in the top of the second hand with a dot that covered with luminous coating and let the wearer can easy read the second hand even in the dark.
The replica rolex Yacht-Master carry with 3135 movement and rolex patented PARACHROM paramagnetic alloy hairspring which with mysterious blue glow.
Rolex launchd the replica rolex Yacht-Master II in 2010, in fact, the new Yacht-Master II added the timing module, and the diameter up to 44mm, but for the people who preference for the classic rolex modelling elements, the Yacht-Master is the most improtant option. Clssical oyster watch bezel, watchband, crown molding and luminous Sweep Second Hand designs, all of these show the eternal charm of the replica rolex Yacht-Master.


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The Department of Labor ("DOL") has issued a statutory interpretation or rule regarding "persuaders" hired by employers to assist the employer in dealing with a labor union. The rule went into effect at the end of April and it has already spawned three lawsuits and legislation in both houses of Congress to repeal it. Read More »
The Supreme Court sided with the U.S. Patent and Trademark Office (USPTO) Monday when it decided that inter partes review (IPR) cannot be appealed under the American Invents Act (AIA) and affirmed the USPTO's "broadest reasonable interpretation" standard for construing claims. Read More »
On Friday, May 20, Bill Hanigan of the Davis Brown Law firm filed separate lawsuits on behalf of Verdell and Marian Johnson, and Marvin and Bonnie Zoch, against Dakota Access Pipeline Company. Both couples are Cherokee County Iowa landowners opposed to the use of eminent domain to seize farmland. Read More »
On May 18th, the DOL issued its new rule raising the minimum annual base under which employees in these categories can qualify for one of these exemptions to overtime. Read More »
On Friday, April 8, Bill Hanigan of the Davis Brown Law Firm filed a lawsuit on behalf of nine Iowa landowners against the Iowa Utilities Board (IUB). Read More »
On Thursday, March 10th, the Iowa Utilities Board (IUB) released its decision regarding Dakota Access' request for a permit to use eminent domain to take private farmland for its proposed Bakken oil pipeline. Read More »
For the past few months, the Iowa Utilities Board has been considering the Dakota Access pipeline case. The IUB will reconvene in open session on March 9, 2016 at 9am to review the draft order and discuss any changes necessary and release a final decision on March 9 or 10. Read More »
A hearing on Thursday, October 8, 2015, at 9:30 a.m. at the Cherokee County District Court will establish whether an
Iowa court has an immediate right to hear arguments about whether Dakota Access will have the power of eminent
domain. The hearing will also determine if three Iowa landowners' lawsuit against the Iowa Utilities Board will continue to
move forward. Read More »
On Monday, July 27, Bill Hanigan of the Davis Brown Law Firm and Richard A. Cook of Herrick, Ary, Cook, Cook, Cook, & Cook filed a lawsuit on behalf of three Iowa landowners against the Iowa Utilities Board (IUB). Read More »
U.S. Citizenship and Immigration Services recently shared important information for DACA recipients who received a three-year Employment Authorization Document (EAD) after February 16, 2015. Read More »


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Lyrics Depot is your source of lyrics to Rape by Ian Hunter. Please check back for more Ian Hunter lyrics.
Artist: Ian Hunter
Album: All American Alien Boy
(Ian Hunter)
He searched through his love like a thief on the run
He searched through his face - to see the guilt water run
But he's fresh out of tears and nobody has come
And justice has got to be done
Oh moon in the city stay open and clear
For his vision ain't good and his mind's disappeared
"Get along mother nature" they spat at your son
So justice has got to be done
And beauty is lying alone in the park
Her friend has gone bowling in the alleys so dark
Where's her knight in white armour who rides a chrome Ford
Justice would seem to be bored
Justice would seem to be bored
A knife full of life penetrated the bait
While he thinks 'o the sister and the mother that he hates
And he thinks he'll get off 'cos he's sick, rich, and stoned
And justice was made to be honed
And justice was made to be honed
And his lawyer is smiling one hell of a smile
'N he's lying all the lies - of the lies in exile
While she's dying of grief he's defending his brief
And justice would seem to be cheap
And justice would seem to be cheap
Well I've searched through the falling, and I searched through the failed
I've searched through the jury - the judge and the jailed
But sleeping beauty is dead no use pricking her thumb
And justice has got to be done
Justice just is - justice just is - justice just is - Not!
Ian Hunter Lyrics
Ian Hunter All American Alien Boy Lyrics
More Ian Hunter Music Lyrics:
Ian Hunter - Cleveland Rocks Lyrics
Ian Hunter - Death 'n' Glory Boys Lyrics
Ian Hunter - Leave Me Alone Lyrics
Ian Hunter - Noises Lyrics
Ian Hunter - Old Records Never Die Lyrics
Ian Hunter - Pain Lyrics
Ian Hunter - Tell It Like It Is Lyrics
Ian Hunter - The Other Man Lyrics


text: 1 Review 1 Ratings Stuffed Squash Blossoms Most Helpful Newest Highest Rating wow this is good .easy too .now i know what to use the masa for. after my tortilla making disaster .zwt9 1 person found this helpful. Was it helpful to you? [Yes] [No] Dienia B. July 17, 2013 Show More Reviews Back To Top Stuffed Squash Blossoms


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Winning a $10,000 buy-in world championship event comes with a certain amount of additional prestige. The fields are smaller, but a victory truly means that you beat the best of the best. Russian businessman Alex Bilokur already had the money. What he didn't have was the gold bracelet. He plays in high roller events around the world for the thrill of the game, and over the weekend, he earned the biggest thrill of all with a victory in Event 28, the pot-limit hold 'em world championship.
"It was my dream [to win]," Bilokur said to the WSOP. "It's been my dream for a long time."
Bilokur had his challenges as he faced a final table that included Chino Rheem, Barny Boatman, Todd Brunson, Matt O'Donnell, Alex Venovski, Ismael Bojang, Pratyush Buddiga and Richard Lyndaker. Rheem held the lead to start the final table, but lost it to Bilokur during the second orbit of play. Boatman, Lyndaker and Buddiga fell early, as O'Donnell thrived. Venovski avoided the straight draw of Brunson to reduce the field to five, and Bilokur made it four when he knocked out Bojang, who failed to gain any momentum on the final day.
Looking for his first WSOP win, Rheem's quest ended when his K-Q flopped K-Q-J and he called all-in against O'Donnell's J-J. O'Donnell continued to coast three-handed, and flopped a straight with 10-8 to end Venovski's tournament and set up what looked like a painless heads-up match for the Florida pro.
Down nearly 9:1 in chips, Bilokur's prospects looked bleak. Unfazed by the challenge at hand, he chipped away and was quickly only down 4:1. Then came a double up, then another, then a few more pots and to everyone's shock, Bilokur was in the lead. With the edge, Bilokur put the pressure on and brilliantly caught O'Donnell making a move with 10-high. A few hands later, the chips went in on a 9d-8d-2c flop. O'Donnell held A-Q while Bilokur was drawing very live with Qd-Jd. A 9s on the turn didn't help Bilokur. The 7d on the river did, and the comeback was complete.
"I've never considered myself a professional poker player," said Bilokur. "I just really love this game and I like tough competition."
This was Bilokur's second major tournament win of the year and third six-figure score in 2014. He has $3.3 million in live tournament earnings ... not bad for an "amateur."
Below are the complete results of Event 28 at the 2014 World Series of Poker:
Event 28: Pot-limit hold 'em world championship
Entries: 160
Prize pool: $1,504,000
Players in the money: 18
1. Alex Bilokur ($398,567)
2. Matthew O'Donnell ($246,310)
3. Alexander Venovski ($178,434)
4. Chino Rheem ($131,705)
5. Ismael Bojang ($98,978)
6. Todd Brunson ($75,681)
7. Pratyush Buddiga ($58,851)
8. Richard Lyndaker ($46,533)
9. Barny Boatman ($37,389)
10. Dan Shak ($30,516)
11. Erik Seidel ($30,516)
12. Scott Seiver ($30,516)
13. Keith Tilston ($25,327)
14. Humberto Brenes ($25,327)
15. John Juanda ($25,327)
16. Don Nguyen ($21,341)
17. Dani Stern ($21,341)
18. Anthony Ruberto ($21,341)


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Definition of oligomer in English:
A polymer whose molecules consist of relatively few repeating units.
Example sentences
- Condensed tannins are oligomers and polymers of flavonoid units linked by carbon-carbon bonds, which are not susceptible to hydrolysis.
- Proanthocyanidin mixtures from grapes are a combination of dimers, trimers, tetramers, oligomers, and polymers.
- The result may be low molecular weight, broad molecular weight distribution, or the presence of nonreacted monomers or oligomers with very low molecular weights.
For editors and proofreaders
Line breaks: oligo|mer
Definition of oligomer in:
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= trending


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Merryn's blog
The financial industry still doesn't get how to treat its customers
The FCA wants credit card companies to help prevent their customers getting in debt that they can't get out of. But they really shouldn't need to be told, says Merryn Somerset Webb.
Brexit: can you really blame Facebook?
Facebook is so good at giving us what we think we want that we never see anything that challenges our world view, says Merryn Somerset Webb. We need to burst our own online bubbles.
ARM deal proves Britain is still a draw – but it's not all good news
Softbank's £24bn acquisition of ARM Holdings proves that post-Brexit Britain is just as good a place to do business as it was before the referendum. But the deal's not all good news, says Merryn Somerset Webb.
The Bank of England takes small steps back to rational thinking
The Bank of England seems to have accepted that the Brexit vote doesn't meant the end of the world as we know it, says Merryn Somerset Webb.
How central banks have stolen your freedom – and killed democracy
If we want any kind of normality to return to capitalism, central banks have got to normalise interest rates, says Merryn Somerset Webb.
Everyone hates the housebuilders – maybe you should buy them
Housebuilders are hated at the moment – they fell by 25% on the day after the EU referendum, and by another 20% on the next. But, says Merryn Somerset Webb, perhaps it's time to buy.
Why your pension problem will soon be accounting history (and why that's good)
Give it 20-30 years and the whole defined-benefit pension saga will be nothing but super-dull accounting history, says Merryn Somerset Webb.
Defined-benefit pensions: killing our economy for all the wrong reasons
Defined-benefit pensions are fast turning into one of the UK's biggest problems. But it's all entirely unnecessary, says Merryn Somerset Webb.
How fund managers have failed us all on boardroom pay
The financial services industry is supposed to operate as capitalism watchdog. Its inability to fill this role properly means that government now feels forced to step in.
Juncker: why he has to go
Jean-Claude Juncker, president of the European Commission, sums up everything that is wrong with the EU, says Merryn Somerset Webb. It's time he went.
British politics: not chaos, but real democracy in action
An awful lot has happened in the last week or so. But it isn't chaos, says Merryn Somerset Webb. Politics is resetting – just as it should in an active and enthusiastic democracy like ours.
Brexit: what it means for Finsbury Growth & Income
Nick Train of the Finsbury Growth and Income Trust looks at the effects of the Brexit vote on its holdings, emphasising the fact that it should be judged over decades, not a few quarters or half-years.


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CytRx Advancing Aldoxorubicin (INNO-206) Development With Pharmacokinetic Study In Patients With Metastatic Solid Tumors 0 commentsOct 17, 2012 8:20 AM
Study is important component of aldoxorubicin development for future regulatory submissions and partnership discussions
LOS ANGELES--(CRWENewswire October 15, 2012)--CytRx Corporation (Nasdaq:CYTR), a biopharmaceutical company specializing in oncology, has initiated an open-label, single-center Phase 1b clinical trial to evaluate the pharmacokinetics of its tumor-targeting doxorubicin conjugate aldoxorubicin (formerly known as INNO-206) in patients with metastatic solid tumors who have either relapsed or not responded to treatment with standard therapies. The data obtained from this study will identify the duration of exposure after infusion of aldoxorubicin as well as define the peak drug levels reached after treatment with two different doses of the drug.
The single-center Phase 1b clinical trial will be conducted under the direction of Dr. Monica Mita at Cedars Sinai Medical Center in Los Angeles, California, and will evaluate the pharmacokinetics and safety of a new formulation of aldoxorubicin administered at doses of 230 mg/m2 and 350 mg/m2 every 21 days for up to 8 consecutive cycles. The company expects to use the results from the clinical trial for future regulatory submissions and partnership discussions.
CytRx holds exclusive worldwide rights to aldoxorubicin. In June, the Company announced data from a Phase 1b/2 clinical trial indicating that aldoxorubicin administered at its maximum tolerated dose showed clinical benefit (defined as partial response and stable disease of more than four months following up to eight cycles of treatment) in 10 of 13 (77%) evaluable patients with relapsed or refractory soft tissue sarcoma. All patients in the Phase 1b/2 trial had either not responded to or relapsed after treatment with between one and three prior chemotherapy regimens.
About CytRx Corporation
CytRx Corporation is a biopharmaceutical research and development company specializing in oncology. The CytRx oncology pipeline includes two programs in clinical development for cancer indications: aldoxorubicin (formerly known as INNO-206) and tamibarotene. With its tumor-targeted doxorubicin conjugate aldoxorubicin, CytRx has initiated an international Phase 2b clinical trial as a treatment for soft tissue sarcomas, has completed its Phase 1b/2 clinical trial primarily in the same indication, recently initiated both a Phase 2 trial for patients with advanced pancreatic ductal adenocarcinomas and a Phase 1b study of aldoxorubicin in combination with doxorubicin in patients with advanced solid tumors, and plans to meet with the FDA in the fourth quarter of 2012 to discuss a potential Phase 3 pivotal trial as a therapy for patients with soft tissue sarcomas whose tumors have progressed following treatment with chemotherapy. Tamibarotene is being tested in a double-blind, placebo-controlled, international Phase 2b clinical trial in patients with non-small-cell lung cancer, and is in a Phase 2 clinical trial as a treatment for acute promyelocytic leukemia (NYSE:APL). The Company completed its evaluation of a third drug candidate, bafetinib, in the ENABLE Phase 2 clinical trial in high-risk B-cell chronic lymphocytic leukemia (B-CLL), and plans to seek a partner for further development of bafetinib. For more information about the Company, visit www.cytrx.com.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Such statements involve risks and uncertainties that could cause actual events or results to differ materially from the events or results described in the forward-looking statements, including risks relating to the outcome, timing and results of CytRx's clinical trials, the risk that any future human testing of aldoxorubicin might not produce results similar to those seen in past human or animal testing, risks related to CytRx's ability to manufacture its drug candidates in a timely fashion, cost-effectively or in commercial quantities in compliance with stringent regulatory requirements, uncertainties regarding whether CytRx will be permitted to conduct a Phase 3 clinical trial with aldoxorubicin as a treatment for STS, risks related to CytRx's need for additional capital or strategic partnerships to fund its ongoing working capital needs and development efforts, including any future clinical development of aldoxorubicin, tamibarotene or bafetinib, and the risks and uncertainties described in the most recent annual and quarterly reports filed by CytRx with the Securities and Exchange Commission and current reports filed since the date of CytRx's most recent annual report. All forward-looking statements are based upon information available to CytRx on the date the statements are first published. CytRx undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
Investor Relations
Legend Securities, Inc.
Thomas Wagner
800-385-5790 x152
718-233-2600 x152
Source: CytRx Corporation
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A "Closer Look" Gallery Talk at the Mead Art Museum
4:30-5:30pm Fri, Oct 3, 2014
Venue: Mead Art Museum at Amherst College
41 Quadrangle Drive, Amherst, MA 01002Contact:
Mead Art Museum
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In conjunction with the exhibition Images of the Unimaginable: Art from the First World War, Aaron Cohen, Professor and Chair of the Department of History at the California State University, Sacramento, gives the gallery talk "A Bitter Truth? World War I in Russian and European Art." This event and the reception that follows are FREE and open to the public.
Get in the Spirit!
In 1637, the Commonwealth of Massachusetts proclaimed that no person should be in a tavern �...
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