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Opening Nebraskas skies: Congress restores funds to North Platte airport
Davis at the Legislature: Paying tribute to the cowboy culture
More opinion
South Dakota Supreme Court: Cattle died from drowning in blizzard
Town Hall set to discuss mega-chicken plant near Fremont
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The North Platte Catholic Schools show chorus 'SaintSations' received a gold medal Monday for their performance at the Nebraska Choral Directors Association competition at Chase County High School in Imperial.
The Saintsations are directed by Janelle Moorhous.
Pictured, front row, from left: Andrew O'Neill, Trey Dodson and Anthony Noffsinger. Second row: Lexi Allison, Bridget McKeon, Rebecca Pasquinelly, Elli Wid and Laura Bjornstad.
Third row: Amanda McClellen, Emma Lindemeier, Matthew Ferguson, Charleigh Kadlecek, Macy Granger, Jamie Smith, Toni Caudillo, Brikelle Torrez and Tanner Hand.
Back row: Justin Gafke, Drew McClellen, Adam Mackley, Breelyn Saner, Bryce Bryn, Alex Harms, Jared Gafke, Jared Brosius, Julia Flores, Erin Nozicka and Cameron Winder.
Flatrock Publishing, Inc.
1300 E 4th St., Suite F
North Platte, NE 69101


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'Songs to capture sadness, isolation and heartache' – The Undercover Soundtrack, Stacy Green
Posted by Roz Morris @Roz_Morris in Undercover Soundtrack on January 16, 2013
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Thessaly La Force is a writer and editor who has worked at The Paris Review, The New Yorker, and the New York Public Library. She is currently attending the Iowa Writer's Workshop and is working on a collection of short stories about objects and aesthetics. Thessaly divides her time between Iowa City and New York City; she also has two cats and shares a birthday with Jane.
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Jigsaw Puzzle (300 Pieces) . Mexico City - The roundabout junction of Calle Londres and Calle Dinamarca. Date circa 1908
Mexico City in the Handbook series from Moon, one of Americaâs leading travel publishers, covering a wide range of international cities, regions and countries and significantly strong on American dest...
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AdvantagesMore filled with excitement than Robbie Williamses pants
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AdvantagesLoads of free stuff to see and do
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House Session, Part 2
The House debated several bills under suspension of the rules.124 views
The House debated several bills under suspension of the rules.124 views
Securities and Exchange Commission (SEC) Chair Mary Jo White testified on her agency's fiscal year 2017 budget. Some of the topics covered at the hearing included combatting…199 views
The House passed the Red River Private Property Act, which would require the Bureau of Land Management to sell land to individuals who own property on the Texas river.227 views
The House began preliminary debate on a budget deficit reduction bill that repeals the health care law's individual mandate and defunds Planned Parenthood for a year. At 1357,…384 views
The House voted on 13 bills under suspension of the rules, including legislation related to airport security.73 views
The House approved several bills, mostly dealing with transfers of federal land with local groups.79 views
The House approved a bill that increases timber production on federal lands. House leadership pulled the fiscal year 2016 bill to fund the Department of Interior and the Environmental…562 views
The House considered H.R. 1735, a bill that would authorize $515 billion for national defense programs and $89.2 billion in war funding for overseas contingency operations.249 views
The House convened for Morning Hour, with members permitted to speak on a variety of topics.217 views
The House debated 10 bills under suspension of the rules, as well as a bill requiring the Homeland Security Department to consider electromagnetic pulse events in planning.255 views
The House convened for Morning Hour, with members permitted to speak on a variety of topics.119 views
The House held a vote on H.R. 5108. Following the vote, members debated 12 bills under suspension of the rules.214 views
The House considered several bills under suspension of the rules.210 views
The House debated under suspension of the rules H.R. 803, a bill that would reauthorize and overhaul a 1998 federal job training programs law that expired in 2003. Members then began…406 views
The House met for Morning Hour, during which members spoke on a variety of topics.236 views
The weekly Republican address was delivered by the authors of more than a dozen House-passed jobs bills who called on President Obama and Senate Democrats to act for the sake of the economy.339 views
Attorney General Eric Holder testified on the Justice Department's fiscal year 2015 budget request, which totaled $27.4 billion, including $25.3 billion for federal programs and $2.1…914 views
The U.S. House of Representatives convened for a legislative session.338 views
Tom Wheeler and Ajit Pai testified about the fiscal year 2015 budget request for the Federal Communications Commission (FCC). FCC Chair Wheeler conveyed his commitment to keeping the…546 views
Internal Revenue Service Commissioner John Koskinen and two other IRS officials testified at an oversight hearing of the agency. Topics included the IRS fiscal year 2015 budget and the…2,034 views


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Taiwan Predicts More Chinese Tourists in 2011 as Rules Ease
Taiwan's tourism bureau expects visitors from China to increase about 29 percent this year as the island allows individual travelers from the mainland for the first time in more than six decades.
"I want to take this opportunity to see my friends in Taiwan during my four-day trip," Chen Yibin, who has visited the island eight times on group tours, said as he stood on the 89th floor of the Taipei 101 observation deck. "I couldn't move around on my own when I was part of a group," said the 45-year-old worker at Xiamen C&D Corp.
The two sides agreed this month to allow individual visitors from Beijing, Shanghai and Xiamen starting today, the latest step in improving ties after opening the island to group tours and direct flights. As many as 500 tourists from China will be allowed to visit each day, pushing arrivals from the mainland to as high as 2.1 million this year from 1.63 million in 2010, according to Alice Chen, deputy director at the Taiwan Tourism Bureau's Hotel, Travel and Training Division.
"Cross-strait tourism economic benefits are more directly reflected in retail sales and the service industry, unlike trade agreements, which may take longer for the effects to be felt," Cheng Cheng-mount, chief economist at Citibank Taiwan Ltd., said in Taipei yesterday.
Travel-Related Shares
China Airlines Ltd., Taiwan's largest carrier, rose as much as 1.8 percent in Taipei trading today and EVA Airways Corp., the second-biggest, climbed as much as 1.4 percent. Formosa International Hotels Corp., the island's biggest listed hotel company, gained as much as 0.5 percent.
Taiwan's Taiex Tourist Index, which tracks businesses including Formosa International, has advanced 26 percent in the past year and the benchmark Taiex index has added 13 percent.
"This is something we have been preparing for a long time," the tourism bureau's Chen said in an interview in Taipei yesterday. Taiwan will review in three months whether the number of tourists and cities should be increased, she said.
The move to allow individual visitors is the latest milestone in efforts to improve ties between the former foes. China and Taiwan have been ruled separately since Chiang Kai-shek's Kuomintang, or Nationalists, fled to the island after being defeated by Mao Zedong's Communists in 1949.
China views Taiwan as part of its territory. The two sides have signed 15 agreements since Taiwan President Ma Ying-jeou took office in May 2008, pledging to focus on improving economic links and abandoning his predecessor's pro-independence stance.
Gain of $4.59 Billion
Ma permitted group visits in mid-2008. Allowing individual travelers may take Chinese arrivals to 4 million next year from fewer than 200,000 in 2008, adding $4.59 billion to gross domestic product by 2012, Barclays Capital estimates.
Ma is aiming for re-election in January on a platform of improved economic links with the mainland. The opposition Democratic Progressive Party, which viewed closer China ties as a threat to Taiwan's autonomy and sovereignty, accused him of selling the island short with a policy of rapprochement "boxed in a frame set by China."
"A successful cross-strait tourism policy will definitely add points for Ma as he faces election next year," Citibank's Cheng said.
Independent Travelers
China overtook Japan last year as the island's largest source of tourist arrivals. In the first five months of this year, Chinese tourists alone brought in NT$24.4 billion ($844 million) of foreign exchange, according to the tourism bureau.
Independent Chinese tourists may bring in revenue of between NT$9.1 billion and NT$19.5 billion a year, if the 500 visitors spend an average $245.43 and stay for a week to the maximum 15 days, Chen of the tourism bureau said.
Spending by Chinese visitors, including businessmen, contributed to 0.72 percent of Taiwan's GDP last year, Chen said. Tourism has attracted NT$79.7 billion of investment in hotels scheduled to be completed in two years, she said.
"Buying cosmetics, fashion accessories and tasting local fruits are the main targets of my first visit to Taiwan," said Zhu Hangyu, 26, who works at a hotel in Xiamen. She and her friends plan to visit Sun Moon Lake during her three-day stay.
Taipei 101, the world's second-tallest skyscraper owned by Taipei Financial Center Corp., is a must-see attraction for Chinese visitors, according to the tourism bureau.
Chinese tourists may help boost revenue at Taipei 101 by 30 percent next year, with some mainland visitors spending as much as NT$10 million each, Michael Liu, a spokesman at Taipei Financial, said at the mall today. Luxury products sold at the mall are sought after by Chinese visitors because they cost about 30 percent less on average than in China, Daphne Lee, Taipei Financial's marketing director, said yesterday.
The island's government forecasts economic growth will moderate to about 5 percent this year from a 24-year high of 10.88 percent in 2010. Officials have raised interest rates and approved property and luxury taxes to curb price pressures, while increasing wages to help people cope with higher costs.


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Microsoft shares surge on news of Ballmer's departure. Ballmer's lack of vision can't carry Microsoft into new age.
Dell To Unify Partner Programs And Channel Training For PartnerDirectDell is expected to announce an update to its PartnerDirect program next week that will include unifying selling tools and education programs of recent acquisitions.
Dell Banks On Partners As It Enters Choppy Waters, Says Channel ChiefDell's channel chief Greg Davis talks challenges, training, partner growth and ponders Round Rock's next chapter.
PC Sales Set For Comeback In 2014, Piper Jaffray SaysPiper Jaffray upgraded its forecast for Intel earnings, citing single-digit growth in anemic PC sales in 2014 thanks to Windows XP retirement and Windows 8.1.
Lenovo To Double In-House Notebook Production in 2014, Report SaysLenovo reportedly will produce 60 percent of its notebooks in-house in 2014, drastically reducing its reliance on original design manufacturers.
The Mobile Quandry: Q&A With Lenovo's Chris FreyCRN's Kathy Kim spoke with Chris Frey, vice president of North America channels and SMB at Lenovo, about the opportunities and challenges around mobility. Following are excerpts.
Upwardly Mobile: Chip Sales On Record Pace For 2013Mobile chips are booming and will drive the market to an all-time high of $61 billion in 2013 as the traditional PC market sags, says IC Insights.
Icahn Dealt Legal Blow In Lawsuit Against DellCarl Icahn loses bid to fast-track a lawsuit against Dell board.
Dell At A Crossroads: 7 Earnings TakeawaysDell earnings come at a tricky time for the company as it navigates a $24.4 billion leveraged buyout and fends off corporate raider Carl Icahn. Here are 7 takeaways from Thursday's earnings report.
Dell's Earnings Beat Wall Street, But Still DownDell's earnings showed 8 percent growth in its enterprise solutions business and a decrease in PC sales.
Lenovo Earnings Soar As Tablet, Smartphone Sales Beat PCsTouting itself as the 'PC-plus' company, Lenovo says it now sells more smartphones and tablets than desktops and notebooks.
Watch Out Apple, Here Comes Carl IcahnApple joins Dell, Nuance, and Netflix in Carl Icahn's list of tech companies to harangue.
Windows 8.1 RTM 'Do-Over' Launch Details Leak OutWindows 8.1 is set for RTM in late August, but MSDN and TechNet subscribers will have to wait.
Icahn's Court Battle Against Dell Delayed Until FridayCarl Icahn's fast-track hearing on Michael Dell's $24.4 billion buyout delayed until Friday.
VMware Hires Mobile, Big Data Exec From SAP To Lead End-User Computing UnitVMware taps a 7-year SAP vet to run its end-user computing unit, which has seen several executives leave over course of past year.
Icahn Buys More Dell Shares, Pushes Legal ActionWith the purchase of additional shares, Carl Icahn ups his ownership stake in Dell from 8.7 to 8.9 percent, or 156.5 million shares.
Carl Icahn Fires Back At Dell: 'War Itself Is Far From Over'Activist investor Carl Icahn isn't mincing words in his reaction to Dell changing the voting rules. The war is "far from over," he said.
Dell Buyout Vote: 10 FAQs And AnswersKeeping track of Michael Dell's epic battle to take his company private is hard to follow. Here is an FAQ to help keep things straight.
Michael Dell Strikes New Deal With BoardMichael Dell and Silver Lake will bump up their buyout bid to $13.75 and add a 13-cent dividend in exchange for a change in the shareholder voting rule.
Carl Icahn Sues Dell To Keep Buyout Vote On TrackCarl Icahn is filing a lawsuit against Dell's board to keep the leveraged buyout vote on track, alleging that the board is favoring Michael Dell over shareholders.


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Definition of accoutre in English:
(also accouter)
verb (accoutres, accoutring, accoutred or accouters, accoutering, accoutered)[with object] (usually be accoutred)
Clothe or equip, typically in something noticeable or impressive.
Example sentences
- The men are fully accoutred in authentic late 17th century military dress, with hand weapons, Regimental Colours, drummers and a living history camp outfit.
- The drawing rooms are splendidly accoutred, the 19 bedrooms individually designed and lavishly furnished and its restaurant is, simply, second to none.
- He, Grey, O'Hara, Harris and O'Hara's work friends (who had there and then agreed to join the Party) were in Unsuri's lavishly accoutred inner-city apartment.
Mid 16th century: from French accoutrer, from Old French acoustrer, from a- (from Latin ad 'to, at') + cousture 'sewing' (see couture).
For editors and proofreaders
Syllabification: ac·cou·tre
Definition of accoutre in:
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Real news. Real funny.
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Umut Benzer
I love frontend. I love when user loves and excites about what I produced. I love to learn new things, I love constant challenges. I always try to do my best. I love to be a part of a team. I love Chrome. I love Chrome Developer Tools! I think #perfmatters and constantly trying to improve myself about it. I don't think application is not finished till it is automated tested in a CI env.
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Phone: (919) 549-8411
The International Society of Automation (www.isa.org) is a nonprofit professional association that sets the standard for those who apply engineering and technology to improve the management, safety, and cybersecurity of modern automation and control systems used across industry and critical infrastructure. Founded in 1945, ISA develops widely used global standards; certifies industry professionals; provides education and training; publishes books and technical articles; hosts conferences and exhibits; and provides networking and career development programs for its 40,000 members and 400,000 customers around the world.
ISA owns Automation.com, a leading online publisher of automation-related content, and is the founding sponsor of The Automation Federation (www.automationfederation.org), an association of non-profit organizations serving as "The Voice of Automation." Through a wholly owned subsidiary, ISA bridges the gap between standards and their implementation with the ISA Security Compliance Institute (www.isasecure.org) and the ISA Wireless Compliance Institute (www.isa100wci.org).
Membership Benefits
Full ISA Membership
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Earned Membership Grades & Reciprocal Memberships
Monday, 01 Aug - Thursday, 04 Aug, 2016
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Houston, TX,
Saturday, 24 Sep - Monday, 26 Sep, 2016
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Monday, 07 Nov - Friday, 11 Nov, 2016
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ISA members have access to dozens of unique benefits. Update your member profile, set your communications preferences, find products and services that are right for you, and more – all from the convenience of your ISA website.
Featured Training: ISA Boot Camps
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ISA IACS Cybersecurity Training Camp (I.C.T.C.)
Featured Whitepaper: Addressing the Workforce Demands of Modern Industry
ISA to develop a new certification program as part of a $23 million grant to fund degree programs and prepare workers for careers in "Mission Critical Operations"
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ISA - International Society of Automation,
Automation Federation welcomes SANS Institute as its seventh working group
ISA publishes second edition of its best-selling book on industrial automation and control system security
ISA and ISACA to co-host 20 July webinar on the importance of integrating information technology and operational technology in industrial cybersecurity
MAVERICK Technologies, ISA's Premier Strategic Partner for Systems Integration, named one of 2016's 50 Best Companies to Watch
ISA salutes 2016 Fellows and Celebrating Excellence Award honorees
More than 130 Experion Orion Systems Improving Safety and Efficiency at Facilities Worldwide
Honeywell's Latest Experion PKS Orion Release Further Optimizes Project Execution and Performance
Ultra Electronics, 3eTI Receives ISO 9001 Accreditation for Enhanced Customer Satisfaction
Honeywell Process Controls Improving Operator Efficiency and Productivity at Russian Refinery
41st Annual Honeywell User Conference Highlights Bottom-Line Benefits of Industrial Internet Of Things
Configurable Embedded Vision System Provides Reliable Image Capture
Honeywell Launches ControlEdge Programmable Logic Controller
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ISA has the resources and expert networks that you need – no matter what position you hold in our industries. Browse the products and services designed to meet the needs of these common industry roles:
ISA gives me the chance to work with science and engineering students in my community. Each year, my section presents an award to a middle school team in the area who compete in a national engineering competition. I feel it's my responsibility to encourage young people to explore careers in automation and engineering.
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ISA's products and services are organized by technical topic – a selection of technologies, trends, and areas of focus that are relevant to your on-the-job performance:
The following ISA standards, technical reports, and recommended practices were withdrawn in the years indicated. Withdrawal of these documents was based on a) the document's material being incorporated into another ISA document, b) the document being replaced by another organization's document, or c) the document's material being agreed upon by the relevant ISA Standards Committee or the Standards & Practices Board to be dated.
If you have any questions about the withdrawal of these documents, please contact Charley Robinson, ISA Standards Manager, at email@example.com.
ISA-TR12.24.01-1998 (IEC 79-10 Mod), Recommended Practice for Classification of Locations for Electrical Installations Classified as Class I, Zone 0, Zone 1, or Zone 2
ISA-98.00.01-2002, Qualifications and Certification of Control System Technicians
ISA-TR98.00.02-2006, Skill Standards for Control System Technicians
ISA-RP92.0.02-1998 (R2013), Installation, Operation, and Maintenance of Toxic Gas-Detection Instruments: Hydrogen Sulfide
ISA-RP92.02.02, Part II-1998 (R2013), Installation, Operation, and Maintenance of Carbon Monoxide Detection Instruments (50-1000 ppm Full Scale)
ISA-RP92.03.02-1999 (R2013), Installation, Operation, and Maintenance of Ammonia Detection Instruments (25-500 ppm Full Scale)
ISA-RP92.06.02-1999, Installation, Operation, and Maintenance of Chlorine Detection Instruments (0.5-30 ppm - Full Scale)
ISA-TR99.00.02-2004, Integrating Electronic Security into the Manufacturing and Control Systems Environment
ISA-91.00.01-2001, Identification of Emergency Shutdown Systems and Controls That Are Critical to Maintaining Safety in Process Industries
ISA-92.0.01, Part I-1998, Performance Requirements for Toxic Gas-Detection Instruments: Hydrogen Sulfide
ISA-92.02.01, Part I-1998 (R2007), Performance Requirements for Carbon Monoxide Detection Instruments (50-1000 ppm Full Scale)
ISA-92.03.01-1998, Performance Requirements for Ammonia Detection Instruments (25-500 ppm)
ISA-92.06.01-1998, Performance Requirements for Chlorine Detection Instruments (0.5-30 ppm Full Scale)
ISA-MC96.1-1982, Temperature Measurement Thermocouples
ISA-RP75.21-1989 (R1996), Process Data Presentation for Control Valves
ISA-50.02-1992, Part 2, Fieldbus Standard for Use in Industrial Control Systems, Part 2: Physical Layer Specification and Service Definition
ISA-50.02-1997, Part 3, Fieldbus Standard for Use in Industrial Control Systems, Part 3: Data Link Service Definition
ISA-50.02-1997, Part 4, Fieldbus Standard for Use in Industrial Control Systems, Part 4 : Data Link Protocol Specification
ISA-50.02-1998, Part 5, Fieldbus Standard for Use in Industrial Control Systems, Part 5 : Application Service Definition
ISA-50.02-1998, Part 6, Fieldbus Standard for Use in Industrial Control Systems, Part 6 : Application Protocol Specification
ISA-82.02.04-1996 (IEC 61010-2-032), Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use
ISA-RP16.1,2,3-1959, Terminology, Dimensions and Safety Practices for Indicating Variable Area Meters (Rotameters) RP16.1 Glass Tube; RP16.2 Metal Tube; RP16.3 Extension Type Glass Tube
ISA-RP16.4-1960, Nomenclature and Terminology for Extension Type Variable Area Meters (Rotameters)
ISA-RP16.5-1961, Installation, Operation, and Maintenance Instructions for Glass Tube Variable Area Meters (Rotameters)
ISARP16.6-1961, Methods and Equipment for Calibration of Variable Area Meters (Rotameters)
ISA-26-1968, Dynamic Response Testing of Process Control Instrumentation
ISA-RP55.1-1975 (R1983), Hardware Testing of Digital Process Computers
ISA-72.01-1985, PROWAY-LAN Industrial Data Highway
ISA-72.02-1993, Manufacturing Message Specification: Companion Standard for Process Control


text:
We'll have more from the Clippers win over the Timberwolves tonight, but for now, here's the Lob City Ledger from ESPNLA.com by myself, Jovan Buha:
Jovan Buha
Senior Contributor at ClipperBlog
Jovan Buha is a staff writer and Digital Content Programmer at FOX Sports. He also contributes to ESPN Los Angeles' Clippers and Lakers coverage. Jovan graduated from USC with a degree in Print & Digital Journalism and a minor in Sports Media Studies in 2014.
Latest posts by Jovan Buha (see all)
- 5 things: Clippers continue domination of Lakers – January 9, 2015
- Team friction? Rivers: 'It doesn't matter' – January 2, 2015
- Bench's inconsistent play costing Clippers – December 29, 2014


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The Society for the Prevention of Anti-Mormonism blog has been retired for some time now. If something really significant happens in the wor
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Similar to the classic Risk board game, and streamlined for quicker play. Border Siege was designed and developed specifically for Android p
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HAMILTON TOWNSHIP — More than 200 public school employees protested state school funding cuts Friday with a noisy picket line outside the Mays Landing Country Club where Gov. Chris Christie attended a fundraiser for Republican U.S. Congressman Frank LoBiondo.
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Original Article
Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets
Version of Record online: 18 MAR 2013
DOI: 10.1002/jbmr.1810
Copyright © 2013 American Society for Bone and Mineral Research
Journal of Bone and Mineral Research
Volume 28, Issue 4, pages 899–911, April 2013
Additional Information
How to Cite
Wöhrle, S., Henninger, C., Bonny, O., Thuery, A., Beluch, N., Hynes, N. E., Guagnano, V., Sellers, W. R., Hofmann, F., Kneissel, M. and Graus Porta, D. (2013), Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. J Bone Miner Res, 28: 899–911. doi: 10.1002/jbmr.1810
Publication History
- Issue online: 18 MAR 2013
- Version of Record online: 18 MAR 2013
- Accepted manuscript online: 5 NOV 2012 06:35PM EST
- Manuscript Accepted: 23 OCT 2012
- Manuscript Revised: 18 OCT 2012
- Manuscript Received: 15 MAY 2012
Fibroblast growth factor 23 (FGF23) is a circulating factor secreted by osteocytes that is essential for phosphate homeostasis. In kidney proximal tubular cells FGF23 inhibits phosphate reabsorption and leads to decreased synthesis and enhanced catabolism of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3). Excess levels of FGF23 cause renal phosphate wasting and suppression of circulating 1,25(OH)2D3 levels and are associated with several hereditary hypophosphatemic disorders with skeletal abnormalities, including X-linked hypophosphatemic rickets (XLH) and autosomal recessive hypophosphatemic rickets (ARHR). Currently, therapeutic approaches to these diseases are limited to treatment with activated vitamin D analogues and phosphate supplementation, often merely resulting in partial correction of the skeletal aberrations. In this study, we evaluate the use of FGFR inhibitors for the treatment of FGF23-mediated hypophosphatemic disorders using NVP-BGJ398, a novel selective, pan-specific FGFR inhibitor currently in Phase I clinical trials for cancer therapy. In two different hypophosphatemic mouse models, Hyp and Dmp1-null mice, resembling the human diseases XLH and ARHR, we find that pharmacological inhibition of FGFRs efficiently abrogates aberrant FGF23 signaling and normalizes the hypophosphatemic and hypocalcemic conditions of these mice. Correspondingly, long-term FGFR inhibition in Hyp mice leads to enhanced bone growth, increased mineralization, and reorganization of the disturbed growth plate structure. We therefore propose NVP-BGJ398 treatment as a novel approach for the therapy of FGF23-mediated hypophosphatemic diseases. © 2013 American Society for Bone and Mineral Research.


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New York, NYUSA
December 5, 2012
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The Green Party has announced its candidates to fight for two Brighton and Hove constituencies in the next general election.
Brighton and Hove councillor Christopher Hawtree is to contest Hove against Tory MP Mike Weatherley and Davy Jones, a nationally recognised expert on citizen participation, will be looking to unseat Conservative Simon Kirby in Brighton Kemptown.
Coun Hawtree said: "I am hugely honoured that the Greens have entrusted me with our banner in Hove, a bellwether constituency for national election trends."
Mr Jones said: "I'm thrilled to stand for Parliament in Brighton Kemptown, having grown up in Saltdean as a teenager, attending the local youth club, playing pitch and putt and, as a student, teaching English to Italian students in Saltdean Lido."
Caroline Lucas, the UK's first Green MP, has already been reselected to stand in Brighton Pavilion.
See the latest news headlines from The Argus:
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- VIDEO: Man, 21, arrested after police pursuit ends up with car smashing into wall


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Effingham Music Fest welcomes Georgia native, Luke Bryan, to Mid America Motorworks Campus on Saturday, October 15th as the final stop on his 2016 Farm Tour. Country music super star Luke Bryan has sold over seven million albums, 27 million tracks, and has had 12 number 1 hits with back-to-back double platinum awards. The two-time Entertainer of the year delivers a live performance energy performing infectious country music!
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- File Size: 991 KB
- Print Length: 145 pages
- Publisher: InterMix (August 5, 2014)
- Publication Date: August 5, 2014
- Sold by: Penguin Group (USA) LLC
- Language: English
- Text-to-Speech: Enabled
- Word Wise: Enabled
- Lending: Not Enabled
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Blurred: A Connections Novella (The Connections Series) Kindle Edition
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"Life presents choices at every curve and it's the choices we make that pave the way for our future."
I would start this review by saying I am not a fan of Ben Covington. I don't necessarily hate him but he's also not on my favorite persons list. But because I enjoyed the first 4 books in the series, I am more than willing to give Ben a chance. I'm glad I did.
I am always open for authors redeeming their not-so-likeable characters, I'm curious and I'd like to read for myself if the character was redeemable or not. Reading Ben's story, or a glimpse of it, from Connected was intriguing enough. Now, on Blurred, Kim Karr gave us a more in depth look at who Ben Covington was when he was with Dahlia and is now that he's back from being "dead". I think it's safe to say that this is not a love story. This is a life story. This is Ben's life story.
We were finally taken to his way of thinking and all the emotions that he's been dealing with before and after that decision he's made years ago that changed everything. He's still not my favorite, I think I need to read more Ben and see him actually rise to the struggle he has with his life but I appreciate being in his thoughts and I now understand him a bit more than I did at the start of the series. It was not easy for me reading his story, I felt the struggle and pain that he was going through. It was obvious how lost he was and that feeling led him to several questionable decisions and actions. I actually felt sad for him. Again, this was not an easy read for me. If you're asking "why are you giving it a 5 if it wasn't easy for you?Read more ›
During the first 2 books Ben comes off as the bad guy, but really I think he was just misunderstood.
Ben Covington made some choices in his life that he regrets. He holds a lot of guilt on his shoulders. And is constantly questioning the what-if's in life. Everything changed for him the day he had to "die" to protect the woman that he loved. Then everything changed again years later when he found out he could return to being who he once was, then discovering everyone and everything had changed., including himself. The love of his life had moved on. His mother passed away shortly after his return. Ben was lost. Depressed and thought he had nothing to live for. He found himself drinking and having sex to fill the void that life had left him. Soon he was disconnected from his family out on his own trying to rediscover who his is. When the FBI called him back to LA for the trail of the century, he regrettably returns, to nothing and no one. Sleeping in a fleabag Motel because that all he can afford. He looks back on what his life turned into. After being arrested for drunk driving he reconnects with his ex-fiance and tries to rekindle their friendship. Then he starts to turn his life around.
Romance that is sizzling hot, guys that will melt your panties right off of you, and stories that keep you captivated from beginning to end.......The Connection Series by Kim Karr has it all. Check it out. I hope you love it as much as I do.
Most Recent Customer Reviews
Review courtesy of Dark Faerie Tales
Quick & Dirty: This book was such a huge disappointment. Read more
Love the characters. Read this in a day. Had to know where the story was going. Can't wait to read more from this series.Published 11 months ago by Christine Stalker
This novella takes us back to the day Ben's mom died. We see what happened with Ben the days and months after. It brings us to the current time that Mended (book 3) ended. Read morePublished 12 months ago by Teri Caviston
If you're hesitant or just just downright against reading this book because you hate Ben with a passion, and don't think he deserves a book, love, or any other good thing…
You... Read more
This was a good quick read and I'm imagining a good set up for the next installment. Can't wait to get started. I just love this series this far!!Published 18 months ago by Jamie Wilson
Ben has been through a lot from losing the love of his life, having to stay hidden for years away from his family and friends, and then figure out how to re-adapt and adjust to his... Read morePublished 18 months ago by Stephanie
bookshelves: prequel-novella, read-august-2014
Read on August 10, 2014
Had a very very hard time connecting with Ben. Read more
Review for Ramblings From This Chick. ramblingsfromthischick.blogspot.com
I really love the Connections series by Kim Karr, but I will admit that I was a bit worried... Read more


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As a result of the traditional artificial gait planning is a relatively rigid and slow, the lack of flexible self-organizing capacity, and the real biological differences between gait. Good use of the biological central pattern generator of the self-excited behavior have a rhythm of movement in order to adapt to a variety of coordination in complex environments, this paper, we propose a biological central pattern generator model for the core of the establishment of biped robot control system, and CPG parameter values of the parameters of genetic algorithm for high-performance distinctions, in accordance with the relationship between human movement, the establishment of the knee, hip and ankle joint movement relation equation. By simulation control mechanism based on the CPG rhythm of the biped robot motion control method is effective, bio-gait biped robot, when the realization possible.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


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From Dust
From Dust is a wonderful piece of interactive art which rarely feels game-like
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Masters Coursework
Residents may complete a Master of Public Health or Master of Health Administration degree from the University of Iowa College of Public Health, or a Master of Science in Health Informatics from the Graduate College. Forty-two hours of coursework are required to complete the Masters of Public Health degree, forty-four hours of coursework are required to complete the Masters of Health Administration degree, and thirty-two hours are required for the Master of Science. Elective courses are available through the Health Management and Policy Department, College of Pharmacy, College of Law, and College of Business.


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IT WAS fascinating to listen to the passion of Winthrop coach Pat Kelsey last week. He wondered, after the Sandy Hook school shootings, why we, as a country, can't find the wisdom to craft a solution to what has become an epidemic. He was speaking as a father of young children. He could have been speaking for all of us.
What was especially impressive about Kelsey is that in our politically correct environment, he had something to lose. Yet, he chose to speak from the heart, anyway.


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Tom Petty & the Heartbreakers
While Petty and the Heartbreakers are the major selling point of this show, Steve Winwood has his own place in rock history. His work in bands including the Spencer Davis Group, Traffic, and Blind Faith, and his big-time light-rock output in the '80s, have made him a household name. Now, with a new album out, he's taking it on the road with the main man: Tom Petty. Petty doesn't always get the credit he deserves as a crafty tunesmith, but sometimes, after you've forgotten just how much you love his music, you can put on one of his records and remember why you fell for it: his to-the-point lyricism and raw, genuine human emotion. It's a big deal—there's something to be said for a rock legend that makes you all cozy-hearted just by the very sound of his warm drawl—and it all comes together tonight.
Wed., July 23, 6:30 p.m., 2008
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22 June 2014 at 1:47 PM
Lucy Hale Makes Her Grand Ole Opry Debut - See the Pics!
About this photo set: Lucy Hale is a vision in white while making her debut at the Grand Ole Opry on Saturday evening (June 21) in Nashville, Tenn. "Little girls dream about their… Read More Here
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The Three Powers
Now published . . . Book 4
Click the cover above for book details
*** Breaking News ***
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text:
These authors contributed equally to this work.
Research Article
Evidence that TMEM67 causes polycystic kidney disease through activation of JNK/ERK-dependent pathways
Version of Record online: 16 APR 2013
DOI: 10.1002/cbin.10081
© 2013 International Federation for Cell Biology
Cell Biology International
Volume 37, Issue 7, pages 694–702, July 2013
Additional Information
How to Cite
Du, E., Li, H., Jin, S., Hu, X., Qiu, M. and Han, R. (2013), Evidence that TMEM67 causes polycystic kidney disease through activation of JNK/ERK-dependent pathways. Cell Biology International, 37: 694–702. doi: 10.1002/cbin.10081
Publication History
- Issue online: 4 JUN 2013
- Version of Record online: 16 APR 2013
- Accepted manuscript online: 2 MAR 2013 08:30AM EST
- Manuscript Accepted: 13 FEB 2013
- Manuscript Received: 13 NOV 2012
- bpck mice;
- cell signalling pathway;
- polycystic kidney disease;
TMEM67 mutations are associated with severe autosomal recessive polycystic kidney disease (ARPKD) in both humans and animals. However, the molecular mechanisms underlying the pathogenesis of PKD caused by TMEM67 mutations remain to be determined. We have investigated the possible signalling pathways involved in the pathogenesis of PKD. Overexpression of TMEM67 in human embryonic kidney (HEK293) cells triggered the activation of overall tyrosine phosphorylated proteins, extracellular signal-regulated kinase (ERK) and c-jun N-terminal KINASE (JNK). Activation was suppressed by pharmacological inhibitors of ERK or JNK. Activation of the mammalian target of rapamycin (mTOR) or p70s kinase (S6K) did not occur, although elevated phosphorylation of eIF4E-binding protein 1 (4E-BP1), a target of S6K, was seen. In animal studies, activation of a variety of signalling molecules was linked to ERK, JNK and 4E-BP1. Significant induction of phosphorylation of tyrosine phosphorylated proteins, ERK and 4E-BP1, at different postnatal ages was detected in mutant kidneys of B6C3Fe a/a-bpck mice, a cystic renal disease mouse model caused by TMEM67 loss of function mutation. Based on these in vitro and in vivo observations, we propose that TMEM67 mutations cause PKD through ERK- and JNK-dependent signalling pathways, which may provide novel insight into the therapy of polycystic kidney diseases.


text:
Chelsea FC has announced plans to take a pre-season tour to Thailand for some friendlies in the summer of 2011.
Although the Blues last went to Asia 2 years ago to play matches in China and Malaysia, this will be their first time back to Thailand in 14 years.
Chief executive Ron Gourlay noted that the club was making the announcement so far in advance in order to maximize their interaction with the "increasing fan base in Thailand as [they] build towards the game [and] are looking forward to bringing the club closer to the fans with a year of activities including [their] world-renowned community coaching scheme."
The tour will end with Chelsea facing off against a Thailand All-Stars side there at the 60,000-capacity Rajamangala National Stadium.
So why the return to Thailand after all this time? Money!
Way back on August 5th, the club announced a new partnership with Singha beer as Chelsea's official beer supplier, meaning that it is the only libation available at Stamford Bridge. Guess where Singha beer is based? Thailand!
Santi Bhirom Bhakdi, the chief executive of Boonrawd Brewery noted "It is a glorious leap forward for Singha Corporation to join hand in hand with Chelsea Football Club, a club that thirsts for victory and accomplishment." Oh, I see what you did there!
The partnership is mutually beneficial, as currently 95% of sales for Singha come in the restrictive domestic market, where the government has strict regulations on alcohol advertising. In working with Chelsea, the brewery expands into the international market to move past those restrictions while allowing the football club to expand its presence in Asia.
Club executives are excited about their return to Thailand in order to boost Chelsea's finances. I'm pretty sure that John Terry and Ashley Cole are excited about the trip as well.
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-Journal of the Royal Statistical Society
Overall, Linear Models with R is well written and, given the increasing popularity of R, it is an important contribution.
-Technometrics, Vol. 47, No. 3, August 2005
There are many books on regression and analysis of variance on the market, but this one is unique and has a novel approach to these statistical methods. The author uses R throughout the text to teach data analysis The text also contains a wealth of references for the reader to pursue on related issues. This book is recommended for all who wish to use R for statistical investigations.
-Short Book Reviews of the International Statistical
The book is very comprehensibly written and can therefore be recommended for beginners in linear models. It is clearly and simply explained how to use R and which packages are necessary to analyze linear models. All in all, this book is recommendable as a textbook for computational linear regression courses and therefore for students and lecturers, but also for applied statisticians who want to get started on regression analysis using the software R.
Dr Faraway uses many examples and graphical procedures to illustrate the methods. This is a great strength of the book. Linear Models with R is one of several books appearing to make R more accessible by bringing together functions from a number of packages and illustrating their use. From this perspective alone it is an important contribution. I feel this book does a nice job of describing the methods available in linear modeling and illustrating the realistic implementation of these methods in a careful data analysis.
-Statistics in Medicine, 2006


text:
Arena Tuesday 11 June 2013
coming up on Friday's show....the poetry of Patrick Chapman, suggestions for good reading in the latest paperbacks and reviews of albums from Cronin, Lori McKenna and Tim Burgess Presents..
Daily arts and popular culture show.
American Author Curtis Sittenfeld on her book 'Sisterland'. The Publishers are Random House.
Singer Judy Collins joins Evelyn O'Rourke to discuss her life and work. Judy Collins plays The Waterfront in Belfast on June 17th and Dublin's Pavilion Theatre on June 18th
Tony Clayton-Lea on 'Scott Walker - The Collection 1967-1970' which is released this week. The collection includes his first five solo albums.
Susan O'Keeffe joins Evelyn O'Rourke to discuss the 2nd annual Yeats Day in Sligo on Thursday June 13th with readings by Michael Fish. www.seasonofyeats.com for more information.
Email: firstname.lastname@example.com
Twitter: @RTEArena
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In this paper, we propose a general framework for graph matching which is suitable for different problems of pattern recognition. The pattern representation we assume is at the same time highly structured, like for classic syntactic and structural approaches, and of subsymbolic nature with real-valued features, like for connectionist and statistic approaches. We show that random walk based models, inspired by Google's PageRank, give rise to a spectral theory that nicely enhances the graph topological features at node level. As a straightforward consequence, we derive a polynomial algorithm for the classic graph isomorphism problem, under the restriction of dealing with Markovian spectrally distinguishable graphs (MSD), a class of graphs that does not seem to be easily reducible to others proposed in the literature. The experimental results that we found on different test-beds of the TC-15 graph database show that the defined MSD class "almost always" covers the database, and that the proposed algorithm is significantly more efficient than top scoring VF algorithm on the same data. Most interestingly, the proposed approach is very well-suited for dealing with partial and approximate graph matching problems, derived for instance from image retrieval tasks. We consider the objects of the COIL-100 visual collection and provide a graph-based representation, whose node's labels contain appropriate visual features. We show that the adoption of classic bipartite graph matching algorithms offers a straightforward generalization of the algorithm given for graph isomorphism and, finally, we report very promising experimental results on the COIL-100 visual collection.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


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Epicdogbunnycat2 says: "This is my dog Eddie, posed with a book in his hand."
Is Eddie studying up on how to become a doggie daddy?
-Sally Squeeps
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Looks like you're deep into "Purgatorio." Quite and island isn't it?
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Theatre Education, Administrative, and Technical Internships
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The Administrative Intern will support the SCT Education office in the 2016-2017 school year. More information about the internship and how to apply will be available in summer 2016.
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