text:
The video is no longer available.
Try searching our site
Latest Videos
Typical Summer SaturdayWatch Chris Spears' Forecast
Back Into the 90s - With Storms - For the WeekendWatch Ed Greene's Forecast
Broncos Training Camp Day 2 RecapCBS4's Mark Haas and Michael Spencer recap day 2.
School Supply Drive Helps Students In NeedDonations benefit Boys & Girls Club of Metro Denver.
Kids Get Front Row Seats To 'Beautiful'Denver Center program reaches out to theatrical future.
Remembering The Big Thompson FloodThe deadly flood claimed more than 140 lives in 1976.


text:
Login using your social account:
There are no posts!
printed.com is an easy-to-use online store for print jobs of all sizes. Since launching in 2011, the company employs
over 250 staff between its two offices in London and Newcastle.
Using the latest print technology, the company provides high quality print at low prices across a diverse range of
over 80 products, from business cards and flyers, to posters and vinyl banners.
© 2011-2016 printed.com Head Office: Threeways House, 40-44 Clipstone St, London W1W 5DW
We accept:
Save on every product, paper stock, finish, size and digital quantity in our jam-packed sale.
Follow the three easy steps below to start saving:
1. Enter your details below to email yourself the promo code
2. Make your order and enter your promo code at the checkout
3. Get 20% off every product, paper stock, finish and digital quantity

subset: commoncrawl


text:
How did your friend get you to babysit her kids for the weekend, or your sister talk you into hosting the next book club meeting? They probably asked when you were anxious about a work project or stressed about making an impending mortgage payment.
Scooped by
Margarita Tarragona
onto Psicología Positiva, Felicidad y Bienestar. Positive Psychology,Happiness & Wellbeing


text:
Rooms - They lean a bit on the small side... But they're incredibly clean and tastefully renovated! Having interior corridors is a nice plus as well as far as safety is concerned...
Location- Not exactly convenient to many places except a sketchy K-Mart. Oglethorpe mall isn't too far but downtown savannah is a lengthy drive.
Service- Excellent! Breakfast is heavy on carbs (duh...) but waffles are a nice touch an it's all pretty fresh! The front desk is incredible. Our experience with Cathy in particular was nothing but premier... A staff that truly understands customer service!
Overall- No nasty surprises! Only downer is location if interested in spending time downtown.
- Official Description (provided by the hotel):
- For affordable accommodations and convenient access to area attractions, come to the La Quinta Inn Savannah Southside, located just six miles south of the historic district/River Street and only half a mile from Hunter Army Base. We are pet friendly, and the front desk is open 24-hours, with fax/copy services available. A Free Bright Side BreakfastTM awaits you mornings in the lobby along with a copy of USA Today. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, TripOnline SA, Hotwire, Booking.com, LaQuinta, Travelocity, Priceline, Hotels.com, Orbitz and Odigeo so you can book your La Quinta Inn & Suites Savannah Southside reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- La Quinta Inn & Suites Savannah Southside Hotel Savannah
- La Quinta Inn And Suites Savannah Southside
- La Quinta Savannah
- Savannah La Quinta


text:
you are viewing a single comment's thread.
I tend to look at non fiction (factual) books as 'historical' documents. On that basis I get quickly disalusioned and bored if I know that what Im reading is mostly nonsense. I read a fair amount of history books too so Im aware of the necessity of reading between the lines and/or ensuring that I read several different of books on a particular subject from a range authors before I take a viewpoint myself.Obviously this goes for the Clough book too so although Im sure I'll get round to reading it and seeing the film some day....I'll be sure to research both sides of the story.


text:
Best buy to let mortgage broker 2016
The majority of buy to let mortgages are only available via brokers. Whether you want to buy or remortgage, we have access to the whole market. Use the buy to let calculator and rate finder below or call us now and let us find the right buy to let mortgage for you.Buy to let explained
- Investors just starting out in buy to let
- Experienced landlords with large property portfolios
- Landlords investing via a limited company
Some of our lenders...
Choose from
Best buy to let mortgage rates
Here's our top 10 best buy to let mortgage rates available today. These best buy to let mortgage rates haven't simply been ordered by lowest pay rate, they also take into account all features and benefits including loan term type, loan to value, fees and early redemption charges.
Ltd Company Buy to Let Mortgage Rates
About a third of lenders offer buy to let mortgages to limited company borrowers, mostly to SPVs and a handful to trading limited companies. Here are the latest rates.
HMO mortgage rates
Listed below are all the buy to let mortgage rates available where lenders will accept Houses in Multiple Occupation as security. Remember every lender has slightly different rules on the size and type of HMO it will accept, so do please talk to our expert brokers for more detailed information.
Buy to let remortgages
All of the buy to let remortgage products currently available in the UK mortgage market. Buy to let remortgage products often provide incentives including free valuations, legal transfer services and discounted lender arrangement fees.
Fixed rate buy to let mortgages
Fixed rate buy to let mortgages are ideal for those who want to know exactly how much their monthly mortgage repayments will be. Fixed rate mortgages lock you into a specific rate for an initial period - usually 1, 2, 3 or 5 years. Here are all of the fixed rate buy to let mortgage products currently available in the UK market.
Discounted tracker rates
Discounted or discount buy to let mortgages provide an initial period in which the lender's standard variable rate or tracker rate has been discounted. Listed below are all of the discount tracker rates currently available in the buy to let market.
Lifetime tracker buy to let mortgages
Also known as loan term trackers these rates track another rate for the term of the mortgage. Here are all of the latest lifetime tracker mortgages in the UK market.
All buy to let mortgages
As a result of having access to the whole buy to let market, Mortgages for Business can offer you access to all buy to let mortgage rates, including those that are not available on the high street. Here are all of the buy to let mortgage products currently available in the UK mortgage market.
Talk to our buy to let mortgage advisersMeet the team
Buy to let: News and insightAll Buy to let News
BTL mortgages arrears to fall below 7,000 by the end of 2016
Keystone's forecast, based on official CML data plus confirmation that all funding lines are open for new BTL business.
No decrease in activity since Brexit vote, says Bank of England
While business uncertainty has risen since the EU referendum, the Bank of England (BoE) so far reports that there has been "no clear evidence of a sharp general slowing in activity".
Gross mortgage lending continues to rise
Latest estimates put gross mortgage lending at £20.7 million in June, representing a rise of 16% on May's lending total of £17.8 billion.
MFB double award winners yet again
For the second year in a row Mortgages for Business has been awarded the title of both Best Broker Customer Service and Best Broker Website at the What Mortgage Awards 2016.


text:
The New York Times
Diary of a Bad Yearby J. M. Coetzee
View All Available Formats & Editions
Diary of a Bad Year takes on the world of politics—a new topic for Coetzee—and explores the role of the writer in our times with an extraordinary moral compass
J.M. Coetzee once again breaks literary ground/b>/i>/b>/i>
J.M. Coetzee's latest book co-written with Arabella Kurtz, The Good Story, is now available from Viking Books
Diary of a Bad Year takes on the world of politics—a new topic for Coetzee—and explores the role of the writer in our times with an extraordinary moral compass
J.M. Coetzee once again breaks literary ground with Diary of a Bad Year, a book that is, in the words of its protagonist, a response to the present in which I find myself. Aging author Senor C has been commissioned to write a series of essays entitled Strong Opinions, of which he has many. After hiring a beautiful young typist named Anya, the two embark on a relationship that will have a profound impact on them both especially when Alan, Anya's no-good boyfriend, develops designs on Senor C's bank account. Told in these three voices simultaneously, Coetzee has created any entirely new way of telling a story, and nothing less than an involving, argumentative, moving novel (The New Yorker).
Editorial Reviews
The New York Times
The New York Times Book Review
The Washington Post
Nobelist Coetzee's 19th book features a stand-in for himself: Señor C, a white 72-year-old South African writer living in Australia who has written Waiting for the Barbarians. C falls into a "metaphysical" passion for his sexy 29-year-old Filipina neighbor, Anya, and quickly plots to spend more time with her by offering her a job as his typist. C's latest project is a series of political and philosophical essays, and Coetzee divides each page of the present novel in three: any given page features a bit of an essay (often its title and opening paragraph) at the top; C's POV in the middle; and Anya's voice at the bottom. C's opinions in the essays are mostly on the left (he despises Bush, Blair & Co., and is opposed to the Iraq War) and they bore Anya, who wants something less lofty. Meanwhile, Anya's lover, Alan-a smart, conservative 42-year-old investment consultant who's good in the sack, and who stands for everything C despises-becomes increasingly scornful and jealous, and eventually concocts an elaborate plan to defraud C. of money. Unfortunately, Anya is little more than a trophy to be disputed, and Alan as an unscrupulous, boorish reactionary is a caricature. While C's essays, especially the later ones inspired by Anya, hold some interest, this follow-up to Slow Yearis not one of Coetzee's major efforts. (Jan.)Copyright 2007 Reed Business Information
Señor C, an aging and ailing writer in Australia, has been asked by his publisher to contribute political essays to a book called Strong Opinions. Having become infatuated with Anya, a beautiful young woman who lives in his apartment building, he hires her to type his manuscript. While Señor C is writing his essays on politics and morality, a morality tale of a different sort is playing out in his apartment, as the young woman's boyfriend tries to tap into the old writer's online bank account. The result reads like a literary hybrid of fiction and nonfiction, with each page alternating between Señor C's observations for Strong Opinionsand dialog among him, Anya, and her boyfriend, Alan. As Anya remarks, we've all got opinions, but if you tell a story at least people will shut up and listen to you. Nobel prize winner Coetzee's thought-provoking and cerebral novel is recommended for academic and larger public libraries. [See Prepub Alert, LJ9/15/07.]
Leslie Patterson
Product Details
- 9780143114482
- Publisher:
- Penguin Publishing Group
- Publication date:
- 10/28/2008
- Edition description:
- Reprint
- Pages:
- 240
- Sales rank:
- 752,018
- Product dimensions:
- 5.00(w) x 7.70(h) x 0.60(d)
- Age Range:
- 18 Years
Meet the Author
Born in Cape Town, South Africa, on February 9, 1940, John Michael Coetzee studied first at Cape Town and later at the University of Texas at Austin, where he earned a Ph.D. degree in literature. In 1972 he returned to South Africa and joined the faculty of the University of Cape Town. His works of fiction include Dusklands, Waiting for the Barbarians, which won South Africa's highest literary honor, the Central News Agency Literary Award, and the Life and Times of Michael K., for which Coetzee was awarded his first Booker Prize in 1983. He has also published a memoir, Boyhood: Scenes From a Provincial Life, and several essays collections. He has won many other literary prizes including the Lannan Award for Fiction, the Jerusalem Prize and The Irish Times International Fiction Prize. In 1999 he again won Britain's prestigious Booker Prize for Disgrace, becoming the first author to win the award twice in its 31-year history. In 2003, Coetzee was awarded the Nobel Prize in Literature.
Brief Biography
- Hometown:
- Adelaide, Australia
- Date of Birth:
- February 9, 1940
- Place of Birth:
- Cape Town, South Africa
- Education:
- B.A., University of Cape Town, 1960; M.A., 1963; Ph.D. in Literature, University of Texas, Austin, 1969
Customer Reviews
Average Review:
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >
I have a deep respect and admiration for Coetzee and have read all his works. This book struck me as too clever in an artificial if not arrogant way.


text:
Discover new restaurants, spas, things to do & more great deals added daily!
We'll send you unbeatable daily deals. You can unsubscribe at any time
By clicking Continue, I agree to the Terms of Service and Privacy Statement
No Thanks
*Valid on 1 unit (min. price $25) per transaction; max 1 use per customer. Exclusions apply.
Full details: gr.pn/promofaq
Relax with the soothing strokes and relieving kneads of a 60-minute massage
51% Off One-Hour Massage
Up to 40% Off Brazilian Dinner at Pampa Brazilian Steakhouse
Wrap Bracelets with Swarovski Elements in Vegan Leather
96% Off Boot-Camp Classes
Up to 50% Off Two-Hour Stand Up Paddleboarding or Kayak Rental
40% Off a Facial with Optional Pedicure
Up to 52% Off 60-Minute Massages
Up to 50% off Sailing Camp
Toopy & Binoo: Fun and Games! – Up to 40% Off
37% Off a Railway Excursion with Wine or Beer
Up to 48% Off a Twilight Train Excursion
Up to 49% Off at Strathmore Golf Club
3-Pack of Sterling Silver Swarovski Elements Stud Earrings
58% Off Black Light Painting Party from Paint Parti
Up to 55% Off at Black Bull Golf Resort
Personalized Pencil Cases from Dinkleboo
50% Off Non-Toxic Dry Cleaning
44% Off Paint Nite Painting Event
Up to 35% Off a Hot-Air Balloon Ride
51% Off at Vivid Salon
Up to 56% Off Mini Golf
Up to 78% Off Oil-Change Packages
Up to 51% Off Haircut Packages
Up to 63% Off Silk or Mink Eyelash Extensions
Apple-Certified Lightning Cable
Up to 78% Off at CalAlta Auto Glass
54% Off a Sunday Special Railway Excursion
Light Weight Bluetooth Fitness Watch and Activity Tracker
Up to 50% Off Shellac Manicure, or Regular Mani-Pedi
Up to 70% Off Spin, Barre, TRX, HIIT and Yoga Classes
Up to 55% Off Brazilian Wax at Avalon Salon & Spa
Up to 71% Off Facials or Microdermabrasion
Samsung Earbuds with Built-In Mic (2-Pack)
Optiks International – C$155 Off Prescription Glasses
Up to 52% Off Three Months of Weight Watchers Canada
44% Off at Koto Sushi Lounge
1 - 37 of 1628 results


text:
acquis communautaire - French(ˈækiː kəmˈjuːnətɛə, aki kɔmynotɛr)
Collins English Dictionarynounthe body of law accumulated by the European Union. Often shortened to: acquis
Word originC20: French, literally: acquired material of the Community
Word usage trends for "acquis communautaire"
View usage over:
Log in to comment on this word.
Train like a Scrabble champion
Allan Simmons' 5 tips on learning words.
Show more
Join our newsletter
All the latest wordy news, linguistic insights, offers and competitions every month.
|Latest Word Submissions
Related Terms
0 results


text:
It's still not sinking in at all that I'm pregnant. I mean I understand that I am and I can definitely feel that something is different but it just hasn't sunk in that this is really happening. I don't know if it's because it's still so early and part of me is keeping a distance from letting myself believe it just in case something goes wrong or if it's just because it's my first and it's so surreal. I mean I used to think when we struggled that I would never get pregnant because I couldn't imagine it happening and then it did and I'm still in shock or something. Is this normal? Lol. I figured as soon as I found out I would start looking at baby stuff all the time and be able to think about nothing but what it'll be like to finally have our baby here with us but I feel like I can't wrap my brain around the concept or something. It's weird...maybe it's pregnancy brain. I can't remember anything as it is right now. Lol. Did anyone else feel this way with their first pregnancies? It could also be because we haven't seen a hb yet. I have another ultrasound next Thursday and we should definitely see it then if it's then because I'll be almost 8 weeks. I wasn't quite 6 at the first one and there wasn't much to see so while that helped it sink in a little it didn't help much. This is driving me nuts! It makes me wonder if there's something wrong and that's why it's so hard to believe. Any input ladies?
Not sinking in
IDK when it'll kick in. haha. I feel like I AM pregnant, but I guess i don't really believe yet that I'm going to have a BABY.
Even seeing the HB I dont feel very reassured.
Hopefully in two weeks at my next u/s I can HEAR a heartbeat and see more of a baby-shape and feel better...
Until then, umm prob not til like 14+ weeks or the 20week scan will I believe it, or when I feel movement, thats when it became SO REAL last time.
Thanks Cait that makes me feel much better. Lol. I'm not the only one. I definitely have no doubts that I'm pregnant. I feel so terrible. Haha. It's just hard to imagine there being a baby in there or that we're going to have one after all of this time of planning and thinking about it. It just feels so surreal to me. I've been home alone resting all week to recover from this awful infection and learn to deal with morning sickness and I figured while I had time to myself it would sink in but nope not really. Haha. My mom said with my sister (her first) that it didn't sink in until she held her for the first time...I hope it sinks in before then. LOL.
I think definately when there's movement it sinks in, at least a little.. I remember my long commute to work in the mornings being pregnant and Brody would "wake up" around 6:00am and start kinda kicking at me on the drive- i would kind of just rub my belly and pet him, haha, but it was really comforting and felt like I had company during all of that alone time, it definately felt real then!!
It comes. When you get bigger and start feeling movement it really sinks in. These are totally normal feelings! I feel the same way, and I've done this before. (A couple of times lol).
I can totally agree with that! I think in my case I'm trying not to get too attached - I've been spotting and that's never ever happened to me before with my 4 previous pregnancies. Ugh...I definitely have to remind myself that there is something growing in there - as if the fatty bloated tummy wasn't enough to do it! I definitely think it sinks in when you start feeling movement. Come on second tri!!!
You're definitely not alone Leah, and its not a first time thing either. I'm almost 12 weeks with #3 and I still don't believe that this will last. I've seen the heartbeat, I'm super nauseous and tired, and yet I've somehow convinced myself that everything is all wrong and there won't be a heartbeat at my next appt. I don't know whats wrong with me lol, I'm such a Debbie Downer. I did the exact same thing with DS2, it wasn't until I was 16 weeks that I kind of finally accepted "Oh, hey, I'm going to actually have a baby in a few months" :D. Like the other gals said, once you hear the heartbeat at every appt, and see it moving around on the u/s, and start showing and feeling movement it will become very real.
It comes. and dont worry, you have plenty of time to go out and look at baby stuff and all that. I find that I dont believe the home test till a dr. tells me yes, you're pregnant. Then, it really doesnt set in till I hear that little train heart beat. And, then it doesnt become real till you feel movement... and then, eventually.. you have that baby in your arms (then you get the wait, this is what was just inside me? really? and the "is this baby really all mine?" and, then, you get home, and its "oh shoot, its all on us now... what did we get our selves into?... lol) any way. Hang in there, it gets more and more real
I say you're completely normal. Took us 3 years to conceive DS. I was excited, but very paranoid and it took me several weeks to start looking at baby stuff. We didn't tell anyone outside of really close friends and our parents until 15 weeks (once we had a 2nd tri appt). Then I started looking at baby stuff and things felt real finally once I felt kicks at almost 18 weeks.
We're still majorly in shock over here that I'm expecting #2 (this was super duper fast!). I haven't even bothered going to the base clinic (military) to get the pregnancy confirmed yet. Doesn't seem real at all.
Leah, that happened to me with my first! I didn't have any pregnancy symptoms other than a missed period--no nausea and unfortunately, I read a lot of stuff online that said I was prone to miscarry. I then started thinking that "this pregnancy didn't count because I would probably miscarry". I know that sounds weird but I think it was me trying to process the whole thing. It's huge! Like you said, it's hard to wrap your mind around it. This is my second pregnancy and I feel different. Sorta like, "I got this".
I'm feeling the same way Leah. It's hard to believe what's going on inside of me. I try not to get too attached just in case. I don't want to jinx myself but it's hard not to feel this way. I have my 1st u/s on Monday. I pray that everything is ok with the baby. I've been pretty much symptom free so that doesn't help me "feel" pregnant. I've been spotting for a few days now and I'm super tired but that's it. I think after Monday it will sink in more for me.
Hope you're feeling better after getting some much needed rest.
it hasnt sunk in with me either. I think when I get my ultrasound on 3/30 and see a heartbeat then I will feel much better!!


text:
Code covered by the BSD License
Download apps, toolboxes, and other File Exchange content using Add-On Explorer in MATLAB.
Be the first to rate this file! 7 Downloads (last 30 days) File Size: 1.08 KB File ID: #33403 Version: 1.0
Java Class Origin
21 Oct 2011
Quickly find the origin for a java class.


text:
News He Must Have Provoked That Dog Somehow
posted by October 6 at 9:47 AMon
A pit bull kills a two-month old baby in Hawaiibut, hey, at least no one is claiming the dog was otherwise sweet and lovable.
Neighbors described the pit bull that killed a 2-month-old boy early yesterday as a loud and aggressive dog that remained locked up for most of the time in a kennel in the back yard of a Waianae home…. "My grandchildren couldn't go into the back yard because I thought that dog was dangerous," said Vidinha, 68.
The dog also attacked the baby's mother, who is hospitalized in stable condition. A spokesperson for the Humane Society in Hawaii notes that "attacks of this nature give dogsparticularly pit bullsa negative stereotype." Yeah, isn't it a pity?


text:
David T. Little's opera Dog Days got a lot of buzz for its 2012 production in Montclair, NJ. Little's 2006 opera Soldier Songs will be presented tonight through 1/18 as part of the Prototype showcase of recent operas.
Brooklyn Vegan has an interview with Little here. Also check out the embedded video trailer below.
PROTOTYPE Festival 2013 – David T. Little's Soldier Songs from PROTOTYPE Festival on Vimeo.
Female Contraception Methods Viagra Patent Expiration Date Prices Lyrica Purchase Phentermine Online Using Mastercard Pills For Acne Viagra Drug Store Darvocet Medication Clonazepam Withdrawals Lipitor Card Cialis Profestional Glucophage Weight Loss Viagra On Line Pharmacy Cause Of Male Hair Loss Viagra Buy Viagra Safe Weight Loss Pills Order Fast Asleep Strips Next Day Delivery Medrol Dose Cialis Dosage Daily Use Ginkgo Biloba Vs Viagra Levitra Interaction


text:
|Home | About | Journals | Submit | Contact Us | Français
Topoisomerase IIα (topoIIα) is an essential enzyme gene in regulating DNA structure and cell proliferation and is encoded by the TOP2A . Using cDNA microarray analysis, TOP2A has been reported to be one of the top genes overexpressed in Wilms' tumour.
To evaluate the role of TopoIIα in Wilms' tumorigenesis and its prognostic value.
TOP2A gene copy numbers were determined using the fluorescence in situ hybridisation technique, and protein expression levels of TopoIIα by immunostaining in 39 samples of primary and 18 samples of metastatic Wilms' tumour.
TOP2A gene amplification was detected only in anaplastic Wilms' tumours, and none of the Wilms' tumours showed deletion of the TOP2A gene. TopoIIα protein overexpression was detected in 97% of Wilms' tumours, and correlated strongly with proliferation, as measured by Ki‐67 (r=0.85). The high TopoIIα expression was associated with the presence of vascular invasion, prominent apoptosis, metastases and adverse clinical outcomes (p<0.05).
Our findings suggest that TopoIIα overexpression in Wilms' tumours is caused by a change at the transcription level, except for anaplastic Wilms' tumours, in which gene amplification was present. High levels of TopoIIα protein are correlated with tumour aggressiveness. The assessment of TopoIIα expression in Wilms' tumour may have prognostic value.
Wilms' tumour, also known as nephroblastoma, is one of the most common solid malignant tumours in children, with an incidence of 1/8000.1,2,3 Wilms' tumour is histologically characterised by a triphasic pattern of blastemal, epithelial and stromal components, which have different proliferating potential.1 Although, with effective treatment, patients with Wilms' tumour have nearly 90% long‐term survival for localised disease and >70% for metastatic disease,2,4 there is still controversy regarding the best therapeutic strategy and potential molecular targets for antitumour drugs, which can further improve prognosis, reduce treatment‐related toxicity and prevent late complications.5,6,7,8
In our previous cDNA microarray study, we reported that TOP2A had the highest expression change (80.8‐fold increase) compared with non‐cancerous kidney.9 Topoisomerase II α (TopoIIα) is an essential nuclear enzyme that regulates DNA topological structure, chromosome condensation and segregation, DNA recombination, transcription and cell cycle progression. Amplification of TopoIIα is predominant in actively proliferating cells and has been reported in non‐neoplastic kidney lesions and several malignancies, including breast, colon and pancreatic cancer, and meningiomas.10,11,12,13,14
TopoIIα inhibitors, antibiotics actinomycin D and anthracycline doxorubicin, along with vincristine, are used as the main chemotherapeutic agents for the treatment of Wilms' tumour.6,7 It was suggested that TopoIIα gene copy numbers and enzyme expression may correlate with the efficacy of anthracycline treatment in breast cancer.10,15,16,17 However, the mechanisms and molecular pathways of chemotherapy‐inhibiting effects are not well understood.
We evaluated TOP2A copy numbers and protein expression levels of TopoIIα in primary and metastatic Wilms' tumours, and examined their correlation with proliferation indices and various clinicopathological characteristics.
Fifty seven cases of Wilms' tumours (39 primary and 18 metastatic) were retrieved from the files of the Department of Pathology, University of Chicago, Chicago, Illinois, USA, with a protocol approved by the institutional review board. Data on histopathological patterns, presence of anaplasia, vascular invasion, capsule or ink penetration were obtained from pathology reports. Clinical data from 39 patients with primary tumours were obtained from the patients' charts.
Paraffin‐wax tissue blocks with primary, metastatic and normal adjacent kidneys were subjected to tissue microarray (TMA). A minimum of two tissue cylinders with a diameter of 1.5 mm were arrayed into a recipient block with a manual tissue microarrayer (Beecher Instruments, Sun Prairie, Wisconsin, USA). The recipient TMA block and 21 conventional blocks were cut into 4‐μm‐thick sections for analysis by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH).
To evaluate the TOP2A gene copy number, we carried out FISH using an LSI TOP2A probe, with two other probes HER‐2 and CEP17 as controls in multicolour probe mixture (Vysis/Abbott, Downers Grove, Illinois, USA). LSITOP2A is about 160 kb, a unique sequence probe direct labelled with SpectrumOrange that hybridises to the 17q21–22 region containing TOP2A. The HER‐2 probe contains about 190‐kb DNA sequences specific for the HER‐2(HER‐2/neu) gene on 17q11.2–q12 and direct labelled with SpectrumGreen. The CEP17 probe direct labelled with SpectrumAqua contains α‐satellite DNA that hybridises to the centromeric region of chromosome 17 (17p11.1–q11.1). The CEP17 probe was used to distinguish true gene amplification or deletion, and as an internal control for chromosome 17 aneusomy. FISH assay was conducted on TMA samples and conventional sections, according to protocols described previously.18 In each sample, an average of 82 (range 30–202) well‐defined nuclei were scored.16,18 Tumours with TOP2A:CEP17 and HER‐2:CEP17 ratios of >2 were considered to be amplified, and tumours with ratios of 1.5:2.0 as indicating the gain of gene copies. TOP2A was considered to be deleted if the ratio was >0.8.10
Antigen retrieval was carried out by heating sections in TRIS–EDTA (pH 9) for 15 min in a microwave oven. Sections were incubated for 1 h at room temperature with mouse monoclonal antibodies against TopoIIα (clone 3F6; 1:50; Novocastra, Newcastle, UK) and Ki‐67 proliferation marker (clone Ki‐S5; 1:50; Dako, Carpinteria, California, USA). This step was followed by 30 min of incubation with goat anti‐mouse immunoglobulin G conjugated to a horseradish peroxidase‐labelled polymer (EnVision, Dako, Hamborg, Germany). Slides were then developed for 5 min with 3‐3′‐diaminobenzidine chromogen and counterstained with haematoxylin. For detection of HER‐2 protein expression, we used the clinically approved HercepTest kit (Dako) according to the manufacturer's recommendations. Negative controls were prepared by substituting primary antibody with non‐immune mouse immunoglobulins.
Nuclear staining of TopoIIα and Ki‐67 was quantified by using the Chromavision Automated Cellular Imaging System (Clarient Inc, Aliso Viejo, California, USA). The nuclear staining intensity was measured on the basis of three related colour parameters: hue, luminosity and saturation.19 The Automated Cellular Imaging System software was programmed, by setting colour‐specific thresholds, to determine brown (positively stained) and blue (negative) nuclei in the outlined areas of interest, and to calculate the ratio (%) of positively stained nuclei to all nuclei (nuclear index). For each section, at least 10 representative regions were analysed and roughly 50000 cells were counted.
The association between the continuous expression levels of TopoIIα and Ki‐67 in the primary tumours (n=39) and the clinicopathological variables was assessed using the t test. Expression levels were dichotomised into low‐expression and high‐expression groups on the basis of the median expression levels (20% and 25% for TopoIIα and Ki‐67, respectively).20 Their relationship with clinicopathological variables was assessed using Fisher's exact test. Differences in expression levels between primary, metastatic and normal tissues were assessed with a mixed‐effects analysis of variance model. The mixed‐effects model was used to account for the within‐subject correlation in patients for whom several tissue samples were available. Progression‐free survival (PFS), defined as time from surgery to developing metastases, to relapse or death, was estimated by the Kaplan–Meier method. Differences in survival between groups were assessed using the log rank test. Results were considered significant only if p0.05. Data were analysed with the Stata software (College Station, Texas, USA).
Our study included samples of 39 primary and 18 metastatic tumours. Primary tumours were from 39 patients, with one tumour per patient. Of these 39 patients, 8 presented with metastases; however, only 3 metastatic tumour tissue samples from 2 of the 8 patients were available for analysis. The remaining 11 metastatic tissue samples included in the analysis were collected from patients who developed metastases later, and 4 more tissue samples were from 3 patients whose primary tumours were not available for study.
In all, 24 of the 39 patients with primary tumours were African‐American and 15 were Caucasian; mean age was 3.4 (standard deviation (SD) 2.36; range 0.5–9) years. The mean primary tumour size was 11.2 (3.2; 0.5–18) cm. The primary cases of Wilms' tumour were classified as stage I (n=15), stage II (n=9), stage III (n=11) and stage IV (n=4). In all, 11 of 20 (55%) male and 4 of 19 female patients (21%) had stage III or stage IV disease. All patients received surgical treatment in combination with pre‐surgical (26%) or post‐surgical (100%) chemotherapy with either actinomycin D or anthracycline oxorubicin, or both, in combination with vincristine. The median follow‐up for all patients was 69.05 (range 3–206) months. Eight patients presented with metastases at the time of diagnosis and 11 patients developed metastases or relapsed 3–76 months later (mean 29.45, median 12 months). Of the 39 patients, 5 (13%) died from Wilms' tumour, including two of the three patients with unfavourable histology.
We found a significant association between PFS, sex and stage: patients who were female (p=0.02) and had a low tumour stage (I and II; p=0.05) had significantly better prognosis. Worse outcome in male patients may be attributed to uneven stage distribution among male and female patients in our cohort, as confirmed by Fisher's exact test (p=0.048). We found a weak association between longer PFS in patients without lymph node metastases (p=0.09) and renal vein invasion (p=0.10), and in patients treated with TopoIIα inhibitors before surgery (p=0.08).
Inherent probe hybridisation efficiency was found in 93.75% of Wilms' tumour samples and normal kidney tissues. TOP2A amplification or gain was detected in 4 (12%) samples of Wilms' tumour with anaplasia: 2 primary and 2 late metastases from the same patients, which also had a simultaneous gain of HER‐2 gene (fig 11).). TOP2A was not deleted in all studied tumours. We found a strong positive correlation between the ratios of TOP2A:CEP17 and HER‐2:CEP17 in samples of Wilms' tumour (r=0.923) and in adjacent normal kidney tissues (r=0.862). The average percentage of aneusomic (monosomic and polysomic) cells was higher in primary Wilms' tumour than in adjacent normal kidney tissue (p=0.003), and higher in metastases than in primary Wilms' tumour (p=0.032). We found that a higher percentage of chromosome 17 alterations (above the median value of 45% for monosomy and 48% for aneusomy) was weakly associated with the presence of metastases at initial presentation (p=0.063 v p=0.09) and tumour progression (p=0.053 v p=0.10).
Positive nuclear TopoIIα and Ki‐67 staining was observed in all 57 samples, whereas staining in adjacent normal kidney tissues was virtually negative (<0.4% positive cells). TopoIIα and Ki‐67 expression levels were found to be the highest in metastatic or recurrent tumours (22.85% and 31.81%, respectively), high in primary tumours (17.36% and 20.94%) and low in adjacent normal kidney (0.38% and 0.26%). Expression was also low in the two stromal Wilms' tumour (2.9% and 4.85%) samples. Mixed‐effects analysis of variation models showed that expression levels of TopoIIα and Ki‐67 were significantly higher in primary and metastatic tissues than in adjacent normal kidney (p<0.0001 for each) and higher in metastatic than in primary tumours (p=0.05 and p=0.02 for TopoIIα and Ki‐67, respectively). Figure 22 shows representative images of TopoIIα expression in primary and metastatic Wilms' tumours.
We found significant differences between primary tumours expressing high and low levels of TopoIIα with respect to the sex of the patients (p=0.048), presence of vascular invasion (p=0.02), prominent apoptosis (p=0.02) and metastases (p=0.04). TopoIIα levels were higher in patients with stages III and IV, anaplastic tumours and no pre‐operative chemotherapy; however, the differences were not significant. The association of Ki‐67 expression levels with clinical and pathological features was similar. The group of patients with low TopoIIα and Ki‐67 expression levels tended to have longer PFS (p=0.09; fig 33).
We found a strong positive correlation between TopoIIα and Ki‐67 expression levels (fig 44)) in 50000 cells/case, by automated image analysis (r=0.85).
TopoIIα nuclear indices were non‐significantly higher (27.75% (11.78%)) than the median value of 20% in all four tumour stages with TOP2A amplification or gain. We found a weak correlation between TOP2A:CEP17 ratios and TopoIIα expression levels in Wilms' tumour (r=0.292).
HER‐2 amplification or gain was low, with a mean HER‐2 copy number ranging from 1.5 to 3.71 per cell (HER‐2:CEP17 maximum ratio of 2.23). Immunohistochemistry for the HER‐2 protein was essentially negative in all samples of Wilms' tumour studied.
By applying FISH, immunohistochemistry, tissue microarray and automated imaging analysis, we showed that TOP2A is amplified in only four samples with anaplastic Wilms' tumour, whereas TopoIIα is overexpressed in most samples. This is apparently caused by mechanisms other than gene amplification. Higher TopoIIα expression levels strongly correlate with tumour proliferation and progression features, such as vascular invasion, local and distant metastases and marked apoptosis (p0.05). There was no evidence of TopoIIα differential expression in predominantly epithelial, blastemal and mixed histological subtypes reported in a semiquantitative study by Granzen and coauthors.21 However, we found that two stromal variants of Wilms' tumour showed a sixfold lower TopoIIα expression than other variants (p=0.0031), and that normal epithelium from adjacent kidney tissues was essentially TopoIIα negative.
The results of TopoIIα immunohistochemistry strongly correlate with those of our previous study of mRNA levels by cDNA microarrays and real‐time polymerase chain reaction9 in tissues with Wilms' tumour, which showed marked overexpression (80.8‐fold) compared with non‐cancerous adjacent tumour kidney tissue. By automated immunostaining, the mean TopoIIα protein overexpression in primary tumours was 45‐fold that in non‐cancerous kidney tissues (17.36% (SD 11.61%) v 0.39% (0.058%); p<0.0001). Our finding of a higher expression of TopoIIα protein in high‐stage Wilms' tumour is consistent with our previously reported data, an increase of mRNA levels in high‐stage Wilms' tumour.9
Over the past 25 years, long‐term survival rates for children with Wilms' tumour approached 90% for all patients; however, the prognosis for patients who relapse is not as good, with only 30–50% survival expected after retrieval therapy.2,7 Therefore, it is important to uncover the mechanisms of drug resistance and its reliable detection to further improve prognosis for children.22 Two main mechanisms have been suggested to explain resistance to TopoIIα‐inhibiting drugs: deletion and mutation of the TOP2A gene ,23,24 whereas TOP2A amplification may cause increased sensitivity to chemotherapy.17,25
In the cases analysed, we found no TOP2A deletion, whereas TOP2A amplification or gain was detected in only a small subset of four tumours. All tumours with TOP2A amplification had unfavourable anaplastic histology and showed simultaneous HER‐2 amplification or gain. Absence of TOP2A deletions may explain the overall high sensitivity of patients with Wilms' tumour to anthracyclines and actinomycin D. However, individual drug sensitivity may vary depending on TopoIIα protein expression levels.
Our findings suggest that measuring the TopoIIα protein expression may have some value in predicting sensitivity to chemotherapy in patients with Wilms' tumour . For instance, patients who underwent pre‐operative chemotherapy tended to have lower levels of TopoIIα expression and lower proliferation indices (13.26% and 17.54%) than untreated patients (18.99% and 22.02%). Interestingly, a cohort of patients who were treated before the operation and who did not show any sign of tumour progression had the lowest nuclear indices for TopoIIα and Ki‐67 (7.67% and 11.06%) in tumours that were removed regardless of stage. Our findings coincide with the previous observation of reduced TopoIIα expression in Wilms' tumours after chemotherapy.26 Our results also indirectly support in vitro data25,27 that the sensitivity of breast cancer cells to TopoIIα inhibitors is dependent on the expression levels of TopoIIα rather than on the TOP2A amplification status.
In contrast with the strong correlation of TopoIIα mRNA and protein levels, we found no correlation between TOP2A status using FISH and TopoIIα using IHC (r=0.29). Mueller et al28 obtained similar results in breast tumours, which showed no correlation between TOP2A copy number and TopoIIα expression levels. These findings suggest that TopoIIα expression is highly regulated at the level of transcription and translation.
Ki‐67 protein expression in Wilms' tumour tissue was about 25% higher than that of TopoIIα expression, but nuclear indices of TopoIIα and Ki‐67 strongly correlated with each other (r=0.85), and were higher in tissues with metastatic, relapsed and anaplastic Wilms' tumour. High TopoIIα expression seems to be a general feature of rapidly proliferating cells, with strong, cell cycle‐dependent connection and accumulation of the TopoIIα active form of the enzyme during S, G2 and M phases of replicating chromatin.29
In summary, the overexpression of TopoIIα in all samples of Wilms' tumour and detection of TOP2A amplification in only 12% of those suggest that the abnormality responsible for raised expression of TopoIIα mRNA and protein is mainly at the transcription level. To our knowledge, this is the first study to correlate clinical and prognostic features with TOP2A status and TopoIIα expression levels in tissues with Wilms' tumour. Our results suggest the potential clinical utility of TopoIIα immunostaining in providing guidance for designing treatment for patients with Wilms' tumour.
We thank Dr Olofunmilayo Olopade for reviewing this manuscript and the Doris Duke Foundation for supporting FISH studies by TG. We also thank Can Gong for her excellent technical assistance with immunostaining and TMA.
FISH - fluorescence in situ hybridisation
IHC - immunohistochemistry
PFS - progression‐free survival
TMA - tissue microarray
topoIIα - topoisomerase IIα
Competing interests: None declared.
Presented in abstract form at the 95th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, March 2005.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Manage your account for business services, plans and devices
How to register | Learn More
Log in to manage your account
Remember me
Fayçal Boujidane is a Senior Contact Center and Unified Communications Consultant at AT&T Services working with customers to develop a strategy and an executable roadmap for their Contact Center and Unified Communications solutions. He has delivered solutions across a variety of customer access channels including voice, video, email, and web.
In his 12+years of experience, he has consulted for dozens of US and global companies seeking to optimize their Contact Center and Unified Communications Solutions, including the Massachusetts General Hospital, the Brigham and Women Hospital, the University of Miami, EMC, Societe Generale, Moody's Investors Service, and ExxonMobile to name a few.
Fayçal holds a Master of Business Administration degree from the University of Massachusetts, and various technical industry certifications for the design and implementation of Cisco Contact Center and Unified Communications technologies including CCVP, CCNP, and Cisco Unified Contact Center Design, Implementation, and Support certifications.
Fayçal also has over 6 years of experience as an adjunct professor teaching various Information Technology classes including Telecommunications, Network Design and Implementation, Information Systems Security, and Information Systems Management among others.
Content Type
Top 5 Things for the CXO to Consider
The Top 7 Considerations for the CXO
Toll-Free Directory Assistance | Reverse Phone Lookup | Advertising Choices
Hosted by AT&T and powered by AT&T CDN Services
© 2016 AT&T Intellectual Property.
All rights reserved. AT&T, the AT&T logo and all other AT&T marks contained herein are trademarks of AT&T Intellectual Property and/or AT&T affiliated companies.36 USC 220506


text:
Chemical Safety Companies serving Palestinian Territories
Current filtering criteriaYou can remove a filter by clicking on the x
Category: Health & Safety ×
Subcategory: Chemical Safety ×
Serving: Asia & Middle East ×
Serving: Palestinian Territories ×
based in Knoxville, TENNESSEE (USA)
EmeraChem is a leader in nanophase chemistry and catalysis for the control of air emissions and Green House Gases (GHG) from power generating facilities, natural gas compression stations and mobile vehicles. As both a developer and manufacturer of catalytic technologies and related systems, EmeraChem has a diverse portfolio of products supported by best-in-class ...
Hazmat Ltd.
based in Rosh Ha`ayin, ISRAEL
Hazmat Ltd., established in 1985, is a leading, multidiscipline risk engineering and consulting company with a proven national and international track record. We offer a wide range of risk and hazard solutions in the fields of Environment, Safety and Emergency preparedness. Based on our professional experience of over two decades, the team identifies hazards, analyses ...
STOCKMEIER Chemie GmbH & Co. KG / Kruse KG
based in Bielefeld, GERMANY
The STOCKMEIER Group continues to grow into a global player for standard chemical products as well as specialties for numerous industries. At our locations in Europe and overseas, we develop, produce, and distribute superior products out of one Hand. Along the way we consistently use modern technology. A certified quality management and over 1.230 trained employees ...
Hydro Flo Technologies
based in St. Charles, ILLINOIS (USA)
Hydro-Flo manufactures process water treatment equipment and systems capable of achieving any water quality goals for your manufacturing process. We manufacture both batch and continuous flow chemical reaction systems, pH adjustment, pH neutralization, multi-stage-process reaction systems, sand filters, inclined plate clarifiers (lamella clarifier), flotation systems ...
Z.I. Chemicals
based in Los Angeles, CALIFORNIA (USA)
Manufacturer of EPA Oil Spill Dispersant, Anti-Corrosive Cleaners for Fixed and Rotary Wing Aircraft. Pipeline degreasers. We are dedicated to customer satisfaction, including research and development to solve problems our customers bring to us. We invite you to experience first-hand our excellent products and personalized customer service.
Nacah Tech LLC
based in Pittsburgh, PENNSYLVANIA (USA)
Nacah Tech has a unique approach for your Thermal Oxidizers and Combustion Systems. Resource saving ideas are key for Nacah Tech LLC thermal oxidizers, combustion systems, afterburners or other thermal air pollution control systems. Nacah Tech becomes a strong, contributing project team member whose combustion experience benefits the customer and their process. When we ...
Environmental and Safety Support Group (E&SSG)
based in Edmond, OKLAHOMA (USA)
Services include: == ENVIRONMENTAL SERVICES == Reporting Permitting Testing Chemical Inventory Analysis == SAFETY SERVICES == Online Training (SafetyU) Online MSDS (MSDS Guru) Onsite Training OSHA Written Programs Chemical Inventory Analysis == OCCUPATIONAL HEALTH SERVICES == Onsite Audiometric Hearing Testing Onsite Respiratory Fit Testing Medical Clearance ...
Light Sources, Inc.
based in Orange, CONNECTICUT (USA)
When Christian L. Sauska and his former business partners established Light Sources, Inc. in 1983, they envisioned a company that offered global OEM lamp designs and manufacturing with state-of-the-art technology and exceptional service and support. This vision lives today through the dedication of approximately 1,000 employees worldwide.Today, Light Sources and its ...
Fluor Corporation
based in Irving, TEXAS (USA)
Fluor is a FORTUNE 500 company that delivers engineering, procurement, construction, maintenance (EPCM), and project management services to governments and clients in diverse industries around the world. Clients value Fluor`s dependability, expertise, and safety to execute complex projects around the world.
GenTech Scientific, Inc.
based in Arcade, NEW YORK (USA)
Why Buy New When You Don't Have To? GenTech Scientific is a market leader in the sales and service of new and refurbished analytical equipment, specializing in gas chromatographs, liquid chromatographs, and mass spectrometers from all major manufacturers, as well as accessories and consumables for those systems. All GenTech Certified™ GC, LC and Mass Spec Systems come ...
Intertek Testing Services Ltd.
based in London, UNITED KINGDOM
Intertek is the industry leader with more than 33,000 people in 1,000 locations in over 100 countries. Whether your business is local or global, we can ensure your products meet quality, health, environmental, safety, and social accountability standards for virtually any market around the world. We hold extensive global accreditations, recognitions, and agreements, and ...
Hoover Materials Handling Group
based in Houston, TEXAS (USA)
Hoover Solutions - the leader in liquid handling solutions for 100 years — providing industries with the most comprehensive portfolio of intermediate bulk containers (IBCs), tote tanks, IBC transport frames, offshore containers, intermodal (ISO) tank containers and related equipment for the storage and transportation of chemicals, liquids and fluids including the industry ...
GE Analytical Instruments
based in Boulder, COLORADO (USA)
GE Analytical Instruments, a division of GE Water & Process Technologies is a leading global manufacturer of Total Organic Carbon (TOC) Analyzers. We also offer Boron and Nitric Oxide Analyzers, Oil-on-Water Monitoring Systems, and other water quality measurement instruments through the GE, Sievers, and Leakwise brands. These state-of-the-art instruments are designed and ...
based in Danbury, CONNECTICUT (USA)
Praxair, Inc., a Fortune 250 company, is the largest industrial gases company in North and South America and one of the largest worldwide. The company produces, sells and distributes atmospheric, process and specialty gases, and high-performance surface coatings. Praxair products, services and technologies are making our planet more productive by bringing efficiency and ...
Consafe Science (I) Pvt. Ltd.
based in Pune, INDIA
CONSAFE is formed in 1988 as a private limited company by chemical & mechanical engineers having long experience in the field of Health, Safety & Environment management (HSE) We provide services - HAZOP studies - Quantitative risk assessment (QRA) - Consequence analysis (CA) - Onsite Emergency management plan (OEMP) - Maximum Credible loss scenario evaluation (MCLS
Fosse Liquitrol Limited
based in Whetstone, UNITED KINGDOM
Fosse Liquitrol supplies a wide range of spill response and spill containment products and provides a comprehensive range of services to assist companies prevent and cope with liquid spills. Established in 1984, Fosse Liquitrol has become industry's 'first choice' for spill prevention, containment and control products. Our products deliver a blend of quality, performance, ...
based in Gonzaga, ITALY
The Company `LANDINI POMPE` was set up in Gonzaga in 1956 by an entrepreneur from the province of Reggio Emilia, NINO LANDINI, who applied the experience acquired from his family (entreprenuers in the farm mechanization from the beginning of last century to sixties) in the farm rain irrigation field. Therefore, this Company has always set itself the goal of keeping a high ...
Lisam UK Ltd
based in Leeds, UNITED KINGDOM
LISAM EASY SOLUTIONS cost-effective approach helps you master the management of your safety documents. Combining user friendly, feature rich software with free telephone support, and modular configuration you can stay in control of your business. Our solutions have already been adopted by hundreds of companies from the chemical products, cosmetics, detergents and gas ...
Locus Technologies
based in Mountain View, CALIFORNIA (USA)
Headquartered in Mountain View, California, Locus' principal focus is environmental and energy information management offered through a Software as a Service (SaaS) platform. Since its founding in 1997, Locus has believed in the power of the Internet to manage all aspects of the environmental business, leading us to invest in the development of a comprehensive suite of ...
Iwaki Pumps
based in Saitama, JAPAN
Iwaki manufactures high purity metering pumps, chemical delivery pumps, sealless, recirculation pumps and non-metallic magnetic drive centrifugal pumps and systems. With a rich assortment of products in stock, we can meet any specification you require.


text:
International LED EXPO 2016, Korea International Exhibition & Convention Center (KINTEX), Goyang City, Gyeonggi-do, Korea, Jun. 22-25 2016. Vektrex partnered with BOB Enterprise for the 2016 International LED EXPO from June 22-25 at KINTEX in Korea. Stop by the BOB booth to learn more about Vektrex DC and DCP current sources and other reliability products…. Read More >
Recent news and information
Guangzhou International Lighting Exhibition (GILE)
Guangzhou International Lighting Exhibition, China Import and Export Fair Complex, Guangzhou, China. June 9-12 2016. Vektrex will be showing their newest current source at this exhibition. Stop by the booth (A16) for demonstrations of the high-power LED light measurement solution that integrates the SpikeSafe™ Performance Pulsed Current Source and Instrument Systems CAS140 spectrometer. Website: Guangzhou International… Read More >
Current Source Induced LED Photometric Measurement Variations Presentation at CORM
On May 16, 2016, Jeff Hulett, Vektrex CTO, discussed Current Source Induced LED Photometric Measurement Variations at CORM (Council for Optical Radiation Measurements). Typical LED measurement systems use source/measure instruments delivering DC or pulsed current. In many of these systems junction temperature is uncontrolled, resulting in LED transient junction heating. This combined with timing variability can… Read More >


text:
Sustainability Saturday: Take 20% off 1+ yards of Eco Canvas Fabric Through 11:59 PM EDT July 30th.
Hello! I am an Illustrator and Designer, in Brooklyn, NY, who loves to create quirky and happy art that will make people laugh and smile and surprise them with silliness! I'm a strong believer that people should be surrounded by things that inspire them,
© 2008-2015 Spoonflower Inc


text:
God/dess Laughs Through Us
Often my clients feel pressure to find the ONE healing modality that fits (like finding the ONE). Yet it is the intention to evolve, learn and move on that makes a great healer. You may work with Tarot and decide that you resonate more with Runes. You may start out as a massage therapist and realize you'd rather be a vet tech. Awesome. No one is judging you from the great beyond. You may — like me in the early days — go through a period of half-assed gurus before you recognize the teachers who are meant for you. Everyone has a lesson to share but that doesn't mean you have to sit at their feet forever. It's your life, so possess it with both hands. My sense is that there is no end point when it comes to a soul's journey — so learn, and move on. There's plenty of time.
You may wish to go back to school, travel or swing in a hammock. You could spend hours learning from great masters on YouTube. Being a healer isn't a one-size-fits-all, so ease up on the pressure and practice unconditional love (my new thing.)
Spirituality doesn't have to be so serious. In fact, I run from those who make it a big drag. Dreary teachers, be gone! More like children, less like church. Discovering the fullest expression of your soul – in whatever outrageous costume you wear – is meant to be fun and (in my case) often irreverent. I have a sense that God/dess loves to laugh through us because this life is truly hilarious.


text:
First, about me. I'm 20 and male and a college student. I am getting a laptop very soon. Of course, I kinda liked GNOME (even though I think KDE is more polished, but GNOME comes with less things that I will never use).
I started thinking of how to make the GNOME desktop and such look nice. Then it came to the topic of the wallpaper. From my nature, I want to have a pretty woman on it ... that got me thinking in term to what do women want displayed on their desktop ...
I know for sure that men without an interest into one particular field don't mind 3 things:
-Hot women (models, actresses, girlfriends, wives, etc.)
-Cars (I am partial to the Mini Cooper since finding parking with it seems easy. )
-BFG (Big ... Guns, again, I am partial to the Barrel M82A )
But the question remains ... what do women want to stare at (or show off?) on their desktop without many apps running on it?
I was also thinking, what about a 'Ubuntu Beautification Project' which involves creating GNOME Themes (most likely based on the ones available at gnome-look.org) or GDM themes or Ubuntu Splash Screens or some such.
Let's make Ubuntu not only a 'Linux for Human Beings' but also 'Linux for Men and Women' ... do the same for kids? (I'm sure they don't mind Spongebob or Fairly Odd Parents).
PS: Ubuntu needs to be a 'Linux for People' ... people don't like the ugly default GNOME. (By 'people' (all lower case) I mean myself).


text:
Cyprus Airways Carries 15% Fewer Passengers in First 10 Months
Cyprus Airways, the country's state-controlled carrier, said it carried 15 percent fewer passengers in the first 10 months of the year after cutting capacity by 17 percent.
Passengers dropped by 210,000 from the year-earlier period, after the number of seats available was cut by 336,000 amid lower demand, the Nicosia-based airline said in a filing to the Cyprus Stock Exchange today. That helped to increase capacity use to 73.1 percent from 71.6 percent.
Cyprus Airways will make a profit of 7.6 million euros ($10 million) from the sale of two spare engines in the coming days. It will also return two leased A330-200 aircraft a year ahead of schedule. That is likely to bring "significant improvements in operating results," according to the filing.


text:
Mari Shten Makeup
For an iPhone / Android mobile version click here.
Profile and About Mari Shten Makeup
Mari approaches make-up as an artist's tool to create shapes and balance the face. "I like to create a flawless look that brings out the best features of the face. I love to see the skin of the person, not the make-up. Perfect skin, seamless blending and clean lines are the key elements of my makeup". Her detail oriented, precise and flawless style of work brought Mari many enthusiastic followers and clients including American Vogue, Glamour, Elle Italia, Sony, Verragio, Make Up For Ever and Victoria's Secret. She has been creating looks for the social personalities of New York and worked with celebrities such as Mariah Carey, Cynthia Nixon, Hilary Duff,
Nick Jonas, Christy Turlington, Amy Schymer, Cecily Strong, Judith Light, Elettra Rossellini Wiedemann, Laura Mvula and Aerosmith's Joe Perry.
When Mari is looking for inspiration and creative energy she travels the world and loves to learn about different cultures.
Mari Shten
For booking inquires, please contact:
Germany: Close-Up Agency
+49(0)40 229 47 93


text:
Home Bunch Sometimes I think people get fixated on the wrong things when they're renovating. They spend wildly here, then get stingy there. Even worse, if you're doing a renovation on your own without the input of a design professional, you'll swing back and forth even more. For example, you'll think the more expensive fireplace insert is important, but then forget about the colour. One… Continue reading
Live Colour Training
eBooks & Large Colour Samples
To give you instant confidence!
Online Colour Training
Interior Colour Consultation
Don't make an expensive colour mistake! Get Maria's advice via email.
Exterior Colour Consultation
Bundle It!
Siding Trim & Front Door Or buy only the solution you need: Front Door or Siding Only


text:
Regular fit
The model (height 5'6& rdquo and chest 33& rdquo ) is wearing a freesize
This bathrobe from ISO certified brand Red Rose is suitable for a wide range of uses- spa, therapy or healthcare. Slip into this soft and snug piece for the ultimate bathing experience.
White and dark pink striped bathrobe, wrap styling, soft pile, open front with quilted mock shawl collar styling, pocket in front on the right with quilting detail at mouth, extended sleeve with quilted band at hem, tie ups at waist and a belt
Machine wash delicate


text:
Wiley, Alexander, 1884-1967
From Library of Congress Name Authority File
Wiley, Alexander, 1884-1967
Instance Of
Scheme Membership(s)
Collection Membership(s)
Additional Information
Birth Date
- 18840526
Death Date
- 19670526
Birth Place
- (naf) Chippewa Falls (Wis.)
Death Place
- (naf) Germantown (Philadelphia, Pa.)
Has Affiliation
- Organization: (naf) University of Michigan
Has Affiliation
- Organization: (naf) University of Wisconsin. Law School
- Affiliation End: 1907
Has Affiliation
- Organization: Wisconsin. District Attorney (Chippewa County)
- Affiliation Start: 1909
- Affiliation End: 1915
Has Affiliation
- Organization: (naf) United States. Congress. Senate
- Affiliation Start: 19390103
- Affiliation End: 19630103
Has Affiliation
- Organization: (naf) Republican Party (U.S. : 1854- )
- male
Associated Language
- eng
- (lcsh) Legislators
- (lcsh) Lawyers
- (lcsh) Public prosecutors
- found: NUCMC data from Milwaukee Public Library for Rhodes, I.G. Papers, 1921-1977 (Alexander Wiley)
- found: WWWA, 1961-1968 (Alexander Wiley, 1884-1967; lawyer and U.S. senator, of Chippewa Falls, Wis.)
- found: Biog. dir. of the U.S. Congress website, October 14, 2014 (Wiley, Alexander, a Senator from Wisconsin; born in Chippewa Falls, Chippewa County, Wis., May 26, 1884; attended the public schools, Augsburg College, Minneapolis, Minn., and the University of Michigan at Ann Arbor; graduated from the law department of the University of Wisconsin at Madison in 1907; admitted to the bar the same year and commenced practice in Chippewa Falls, Wis.; district attorney of Chippewa County 1909-1915; unsuccessful Republican candidate for governor in 1936; engaged in agricultural pursuits and banking; elected as a Republican to the United States Senate in 1938; reelected in 1944, 1950 and 1956 and served from January 3, 1939, to January 3, 1963; unsuccessful candidate for reelection in 1962; chairman, Committee on the Judiciary (Eightieth Congress), Committee on Foreign Relations (Eighty-third Congress), resided in Washington, D.C., until a few days before his death, May 26, 1967, at High Oaks Christian Science Church Sanitarium in Germantown, Pa.; interment in Forest Hill Cemetery, Chippewa Falls, Wis.)
Change Notes
- 1992-06-10: new
- 2014-11-04: revised
Alternate Formats


text:
Related quotes
"The essays are all-essay exams. The average American student taking essay exams? Are you kidding me? Oh, that would never happen."
"Metaphorically these essays move as a quiet but observant coast-guard cutter among the rocks and islands up and down the littoral of our life."
"Obstacles don't have to stop you. If you run into a wall, don't turn around and give up. Figure out how to climb it, go through it, or work around it."


text:
Aug 16, 2010
VillageDeb Profile
Forums Owned
Recent Posts
Village Theatre Company hosting Auditions for SCHOOL HOUS...
Village Theatre Company will be holding auditions for School House Rock on Thursday August 19th from 6 - 8 PM at the Laurel Grange Hall 21 Gardent Street in West Newbury. Auditions are for those 18 and under, but there are a few parts for adults. Great songs like I'm just a Bill, Interplanet Janet, Conjunction Junction - just to name a few. If you can't make that audition, there will be another on Saturday, August 28th from 12 - 2 PM again at the Grange. The production will be in mid-November. Come join our student body, we promise that THIS School will ROCK!!! For more information, email [email protected] ecompany.org, or visit our website at www.villagetheatre company.org. (Aug 16, 2010 | post #1)
Q & A with VillageDeb
West Newbury to Cambridge
I Belong To:
Village Theatre Company www.villagetheatrecompany.org
I Believe In:
Copyright © 2016 Topix LLC


text:
I have a 2000 Oldsmobile Alero with a 2.4L Twin Cam engine that is pouring out oil from the top side of the engine on the drivers side. The leak is just below my spark plug coil. I was wondering if anyone could tell me where this is coming from and what it is?
Friday, September 14th, 2012 AT 8:51 PM


text:
From number-one New York Times best-selling author Nora Roberts comes a trilogy about the land we're drawn to, the family we learn to cherish, and the people we long to love.…
With indifferent parents, Iona Sheehan grew up craving devotion and acceptance. From her maternal grandmother, she learned where to find both: a land of lush forests, dazzling lakes, and centuries-old legends. Ireland.
County Mayo, to be exact. Where her ancestors' blood and magic have flowed through generations - and where her destiny awaits.
Iona arrives in Ireland with nothing but her Nan's directions, an unfailingly optimistic attitude, and an innate talent with horses. Not far from the luxurious castle where she is spending a week, she finds her cousins, Branna and Connor O'Dwyer. And since family is family, they invite her into their home and their lives.
When Iona lands a job at the local stables, she meets the owner, Boyle McGrath. Cowboy, pirate, wild tribal horsemen, he's three of her biggest fantasy weaknesses all in one big, bold package.
Iona realizes that here she can make a home for herself - and live her life as she wants, even if that means falling head over heels for Boyle. But nothing is as it seems. An ancient evil has wound its way around Iona's family tree and must be defeated. Family and friends will fight with each other and for each other to keep the promise of hope - and love – alive.…
Don't miss the next two books in the Cousins O'Dwyer Trilogy!
©2013 Nora Roberts (P)2013 Brilliance Audio, all rights reserved.
I haven't read the print edition yet.
Katherine has to be one of the best narrators that I have ever heard. She had great accents and change of voice for all characters. During all parts of the book she actually made me feel like I was there.
I love Nora Roberts books and Katherine was the perfect narrator.
"Horrible Narration!"
It amazes me that Nora Roberts/JD Robb has the most perfect narrator for her "In Death" series yet, consistently has a horrible narrator for her romance novels. The narrator's accent was distorted and it was very difficult to listen to her as she "spoke" in the main heroine's voice --made her sound like a 16 year old!! (toss up between her and the one who did Fifty Shades there..). The Irish voices sounded like it was being read by a old woman--which fit the "backstory" part, I suppose but had no right being part of the more modern sections. I got halfway through and then bought the actual book. The voices in my head sounded better. Are you going to re-do this one too? Like you did for Whiskey River?
"I LOVE Nora Roberts Books"
I enjoyed the story and the reader.... The reader can take a good book and make it great ..... with Nora and Katherine we have a great book and a great reader
"Legends, witches, battles & love in one story"
I would recommend the book for anyone who enjoys fantasy-type genres. There's something for everyone to enjoy in the story line.
The story bringing all the characters together holds your attention with the conflicts my favorite moments. And with Nora Roberts as the author, the romance between characters is lovely....
This was my first experience with her as the reader. She does a good job in distinguishing the various characters with voice inflections suitable for what's going on.
I'm not a good copy writer.....
I'm glad another book is being released this month. I've already pre-ordered a copy.
"Narrator yells too much"
I was really looking forward to this book but if the same person narrates then I will not be listening. She didn't tell the story, she overacted the part. It was nerve wracking to listen to.
wife,mother, hard worker... and lover of romance and wit
"Another Nora Roberts Trilogy (but ok for all that)"
this is a typical Nora Roberts trilogy... with yes the same characters wearing different names, different faces, and in different circumstances.
this is not a big problem for me as I always liked those characters but i know it can be a huge issue for those who are always wanting something different.
the main girl from this book Iona, is very much like Nell, (from ms Roberts three sisters island trilogy.) bright sunny, pathetically eager to please, just coming into her own powers...
Iona comes to ireland to find the dark witch. (her heritage).... joins with her cousins to fight ancient evil, meets the man of her dreams, decides she no-ones floor mat, and goes out and kicks some butt.
I could draw lots more character and plot parallels to other books Witten by Ms Roberts (keys trilogy, three sisters island, the pagan stone, Galhager- Irish jewels trilogy, etc.) but i wont
like i say if this is a problem don't try this series, instead try her vampire trilogy... that was unique for Nora Roberts (if a bit gory... but well they were vampires after all)... the first one was called Moragan's Cross
oh, i guess i should also mention that the beginning of the book was kind of slow and long... but good background for the present day story plot, and I didn't particularly care for the narrator (cant quite put my finger on why... but there it is)
I must say I had fun making the parallels to her other stories and finding the subtle turns in the plot... then i would say, "well thats a little different anyway", and i am making some predictions for the next 2 books... (I bet Im right... mostly anyways)
"can't wait for the next book!"
i've listened twice already. It is fun and mysterious at the same time
the characters were genuine and well developed.
no i have not but i look forward to another performance by Katherine Kellgren.
the book provided an emotional journey through the realm of the real and surreal. i laughed and cried at various places. most of the tears were at the beauty of what i was hearing.
"Couldn't get passed the prologue."
I usually love Nora Roberts, but I just couldn't get passed the first few pages. When the evil force started molesting the little girl in her dreams--that's when I quit listening.
"Almost, but Doesn't Quite Make It"
I don't read a lot of Nora Roberts, but I can tell fantasy isn't her forte. Her creativity is impressive, and she's obviously a talented writer, but this story was missing some elements that would have taken it from good to great. For me, the most distracting part of the book was the reader. I didn't care for her performance at all.
I'm not sure that I've read a book quite the same as Dark Witch, in that it is a romance author attempting to do fantasy with some romance. While it follows the same formula as many fantasy books, you can tell this isn't the author's natural genre. For people who don't read a lot of fantasy, this book may have gone over better. For someone who does read a lot of fantasy, it did come off as a bit amatuerish, despite the fact that Nora Roberts is a world renouned author.
No, I wasn't a fan of her performance of the book. I appreciate the voices and effort on the accents, however, she over exaggerated the dialogue and was frankly, too loud. Her excited voice sounded a bit hysterical. It was very distracting. She would probably be much better if she took it down a notch or two.
I think there is a follow up book, but I think if Nora Roberts works on fantasy writing a bit more, it could be quite good. I got the sense that she tried to write this one as she does her other romance books, but you can't just leap into fantasy romance as you would another genre. I think the characters can be developed more, and the story line could be a bit more complex, but overall the story was enjoyable.
I liked the story line enough to try the second book, and am hoping that they'll get a bit better with time. I don't primarily read romance novels, but I do love fantasy novels with a dash of romance, so I have high hopes.
"I had high hopes"
I really enjoyed the first chapter; setting up the book's storyline, but the following chapters fell woefully short in carrying that feeling through the remainder of the book. I kept having the feeling that I was listening to Stephanie Meyer's version of Anne Rice's "The Witching Hour" (the first book in the Mayfair Witches Trilogy). The rest of the book was all too happy and too neat, with everything working out too easily for the protagonist.
This is my first Nora Roberts book, and while I think everyone deserves a second chance; I guess I'll have to wait and see. I know for sure, that I won't be listening to (or reading) the other two books in the series.
I thought that Katherine Kellgren did an excellent job as the reader.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


text:
There are currently 415 users online. 106 members and 309 guests
Most users ever online was 4,561, 11-01-2015 at 23:20.
Got my shipping notice today! Woohoo!AngryDaddyBird Today, 18:12
I don't mind paying nightly, it's the per person I have a problem with. I wholeheartedly agree that we need to do what we can to keep these lands public.....withoutgoobie Today, 18:07
Just ordered a 20deg Phoenix Hunter Green on the outside.. Does anyone have a photo of this color configuration?Snydman Today, 18:07
Well I think I completed my DIY tarp today. Ended up spreading the wealth purchasing things from a bunch of the vendors.
Tarp is the
Hello Tumbleweed!harleyfatboy316 Today, 18:00
I've had more than enough warm, HOT actually!! I'm ready for cool fall days, which lead to..............frozen butts!!!goobie Today, 17:59
Your first time backpacking but, have you camped along or visited the Northshore before? The hiking trails inside Gooseberry Falls,
Rubbing alcohol also removes sap.DrPhun Today, 17:58


text:
Rural Law Enforcement
FULL LIST OF Rural Law Enforcement - page 11 Articles
2 Va. deputies fatally shot, suspect killed - Sniper fired from mountainous area; later killed in shootout
SD sheriff oversees more bison than people - Thanks to a judge, this gun-toting tenor now spends more time with some 6,000 bison than people
Border chief, mayor arrested on gun running charges - 11 suspects total in El Paso scheme
Five 'Sovereign Citizens' plot to kidnap, kill Alaska cops - Members of the domestic terrorism group also plotted to kill a judge, claiming courts should have no authority over them
Calif. cops close beaches for tsunami advisory - Closed Highway that runs along San Francisco's western coast and warned people to stay away from the beaches
Philly cops taking top jobs in the quiet suburbs - "I would drink coffee... and read about the shootings," a Chief says. "Now I drink tea and read about auto accidents"
Maine traffic stop yields Ecstasy cache - Discovered a backpack with a stash of about $1,800 worth of Ecstasy
Video: Cop thrown 15 feet in icy wreck - The driver's vehicle slid on the icy road, slamming into the squad car and knocking the second officer across the snow
Fresh snow tracks lead Wyo. cops to burglars - Cheyenne police officers followed prints in the snow Sunday and caught two alleged car burglars
Arizona tribal police officer killed by stray trailer - The officer had only been with the department for 30 days at the time of the accident
Small town turns to cameras to cut crime - Residents weigh pros and cons of video surveillance
Cop shoots defendant in Ala. courtroom - The judge pulled a gun on a crutch-swinging defendant who went wild after he was found guilty of harassment
Gov. wants more cops on northern border - There is more known terrorist activity in Canada than in Mexico, yet only 1 percent of the border is being policed
Fugitive Ore. cop shooter is avid outdoorsman - Cops believe he's holed up in a vacation home in a secluded neighborhood less than a block from the Pacific Ocean
Friends: Ore. officer shooting suspect is paranoid - Slipped deeper into a depression after a breakup and entertained paranoid fantasies about being pursued by police
PoliceOne top 5
1 Prosecutors drop all remaining charges in Freddie Gray case
2 Country music duo under fire after requesting armed cops not be allowed backstage
4 Video: Cuffed suspect opens fire in back of cruiser, is killed by police


text:
Fractals for the Classroom: Strategic Activities Volume Three
Springer Science & Business Media, Mar 1, 1999 - Education - 107 pages
This third and final volume of Strategic Activities on fractal geometry and chaos theory focuses upon the images that for many people have provided a compelling lure into an investigation of the intricate properties embedded within them. By themselves the figures posses fascinating features, but the mechanisms by which they are formed also highlight significant approaches to modeling natural processes and phenomena. The general pattern and specific steps used to construct a fractal image illustrated throughout this volume, comprise an iterated function system. The objective of this volume is to investigate the processes and often surprising results of applying such systems. These strategic activities have been developed from a sound instructional base, stressing the connections to the contemporary curriculum as recommended in the National Council of Teachers of Mathematics' Curriculum and Evaluation Standards for School Mathematics. Where appropriate, the activities take advantage of the technological power of the graphics calculator. The contents of this volume joined with the details contained in the prior two books. Together they provide a comprehensive survey of fractal geometry and chaos theory. The dynamic nature of the research and the experimental characteristics of related applications provides an engaging paradigm for classroom activity.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Selected pages
Other editions - View all
Common terms and phrases
270 degrees Activities 8.4 affine transformation algebraically algorithm applied ation Off Hori Base Copy Scale binary coordinates CD CD CD chaos game chaos theory combinations conjugate Coords corresponding decimal coordinate diagonal digits eight motions eight possible eight symmetries entries equations family of fractals final image formula fractal image fractals shown Function Composition geometric genetic code Goto Gotol graphing calculator grid Heinz-Otto Hori set Vert horizontal identify image figure image point Implicit Discoveries initial figure iterated function system Kummer's Criterion line symmetry linear lines of symmetry mathematics matrix NESTED ADDRESS Orient original figure Pascal's triangle pixel position ratio reduced copies replica San Juan College Saupe screen self-similarity structure sequence set Vert Base shaded cells Sierpinski Curve Sierpinski triangle Specific Directions square back Stage 1 Stage Strategic Activities symmetry computer symmetry transformations three cells University of Bremen Vert Base Copy vertical whole image whole object
Popular passages
Page x - The mathematics curriculum should include investigation of the connections and interplay among various mathematical topics and their applications so that all students can — use and value the connections among mathematical topics; use and value the connections between mathematics and other disciplines.
Page x - One interpretation of the reform vision of school mathematics presented by the National Council of Teachers of Mathematics in its Curriculum and Evaluation Standards for School Mathematics...
References to this book
Explaining Chaos
Peter Smith
Limited preview - 1998
All Book Search results »


text:
Inspiring People in our Region: Brenda Linares, MLIS, AHIP Outreach Librarian and Coordinator of User Services Graduate AssistantsThursday, April 2nd, 2015
"…by reaching a small group of people, you have already made a difference."
Brenda Linares, MLIS, AHIP
University of North Carolina (UNC), Chapel Hill
Chapel Hill, NC
What is your position?
I serve as the Outreach Librarian and Coordinator of User Services Graduate Assistants at the Health Sciences Library at UNC Chapel Hill.
Is there something in your own personal story that led you to do the work you do?
As a Latina immigrant, I grew up with the experience of noticing the big digital divide and health disparities that impact the Latino community. When I became a medical librarian, I wanted to reach out to those communities affected by health disparities and make a difference with quality information. I know that well informed people will make better decisions about their lives; therefore, I felt that I could make a difference in someone's life by providing the right information at the right time. Being a medical librarian has provided me with the opportunity to reach out to those communities with tools and health information that can help them improve their health.
What do you love most about your outreach work?
I love that I get to create new partnerships with diverse groups such as community colleges, public librarians, nursing homes, and community organizations. I can provide some assistance with pointing people towards authoritative health information and providing a tool for people to make better health choices. I love to see people's faces light up when I show them helpful information in MedlinePlus (and their tax money at work)! It is always a rewarding feeling when I find someone information on a topic they are researching and it makes sense to them.
What is the biggest challenge in what you do?
I always wish I had more time to do outreach in the community. There is a lot of potential and also a great need to educate and reduce the health disparities impacting multiple minority groups. Because a lot of people have access to the Internet and mobile devices, we forget that there is still a big digital divide and that creates a challenge in how you can reach out to people. There is always the need for resources.
What has been the most fulfilling part of your work in terms of health outreach to your community's underserved populations?
I love providing health information to people, especially when they find a page on their health topic! One of the best groups to work with is kids. They are sponges and you know that they listen to what you say to them. Kids are great listeners and love a challenge. I really enjoy showing them some of NLM's interactive resources such as Tox Town and Tox Mystery! They love playing with Toxie and getting a certificate of completion at the end of the game. I also have seen kids show their parents the website and health information presented on MedlinePlus and even search for information for their parents. It's great to feel like you can reach out to the parents and the kids at the same time.
What do you see as the biggest health concerns in the communities you serve?
When I was in Miami, one of the issues that stood out to me was how people assumed that everyone in Miami was rich and had access to health care. In our health fairs when we went to Key West for example, many of the locals do not have access to quality health care. For them the annual health fairs were their annual check-ups. At these health fairs, the medical students came to that area with free medical services. Therefore, the locals drove long distances to make sure they took advantage of that. The same happened in Broward County, which included Little Haiti. Southern Florida is a very diverse place with a mixture of all socio-economic status and diverse languages. In my current project with community colleges, I learned that in the academic setting, community colleges are left behind in terms of outreach and collaboration. That is why I am glad that NN/LM is taking extra steps of reaching out to this group. I have been able to meet with several community colleges librarians and can see there is a need to promote a lot of NLM's resources and funding opportunities from the NN/LM.
How did you first come to know NN/LM SE/A?
I learned about the NN/LM when I was an NLM Associate Fellow in 2007. We had the chance to visit the RML office at the University of Maryland and learned about the funding opportunities for outreach projects and the importance of health literacy.
In what ways has NN/LM SE/A been of help to you?
I have been fortunate to have the RML provide funding for two major outreach projects that I have been involved with. My first project was doing outreach to free clinics and promoting MedlinePlus to the medical students who interacted with the patients. We were able to buy iPads that the students could use to interact with their patients and educate them on various personal health topics. The second project is the one with community colleges. We did an information needs assessment of the students and the faculty in nursing, geriatrics, and occupational therapy classes. We learned that students wanted interactive tools to learn the materials presented by their faculty and librarians. With this information, we decided to collaborate with two community colleges, Central Carolina Community College and Durham Technical Community College. We are working on creating two interactive modules that the librarians and professors can use with their classes to learn about evidence-based practice resources and consumer health information resources.
Can you share a success story about the impact of health outreach in your community?
I always remember doing the health fairs in southern Florida when I worked at the University of Miami. I loved working with the kids and showing them Tox Mystery! They loved Toxie and I enjoyed seeing the kids play the games and then the parents playing with the kids learning together about how to avoid toxins. The kids were always excited to get their certificate of completion when they were done with the game.
What advice would you give others who are interested in doing health outreach work in their communities?
First of all I would tell them that outreach is a very rewarding thing to do! Any ideas they might have can work! Health literacy is important and by reaching a small group of people you have already made a difference. Also I would tell them that the NN/LM funds all types of outreach projects that show that it will have a positive impact in the community. All ideas are welcome!
I would also advise people to learn more about the community they want to work with. They should know about their culture, language, environment, and other important aspects of that community that will help them create a partnership, collaboration, and relationship.


text:
Move website to new server - cpanel
This project was successfully completed by andreihc85 for $30 USD in 2 days.Get free quotes for a project like this
Completed by:
Skills Required
Project Budget$30 - $250 USD
Completed In2 days
Total Bids13
Project Description
I have a cpanel website back up file that I need copying to a new server.
It is a small joomla site (about 5 pages) but most important is the emails need to be preserved and accessed.
Thank you
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Human Resources and Security Specialists should use this tool to determine the correct investigation level for any covered position within the U.S. Federal Government.
An agency is not required to make an accommodation if it can demonstrate that providing the accommodation would impose an undue hardship on its everyday operations. An undue hardship is an action that requires "significant difficulty or expense" in relation to:
Also, the Computer/Electronic Accommodations Program (CAP) at the Department of Defense may pay the cost of any technology-related accommodations for covered agencies. Contact the CAP for more information.
If a client of the State vocational rehabilitation program is being hired, the State agency may pay for those accommodations that the individual would be able to use at any job site (e.g., a Braille notetaking device, an assistive listening device for use with the telephone). The State agency generally does not pay for accommodations to a work station or worksite that must then remain at that location after the individual leaves.
If a client of the Vocational Rehabilitation and Employment Service of the Department of Veterans Affairs (VA) is being hired, the VA may pay the cost of accommodations.
There was an unexpected error when performing your action.
Your error has been logged and the appropriate people notified. You may close this message and try your command again, perhaps after refreshing the page. If you continue to experience issues, please notify the site administrator.


text:
I am working on a multi-thread program, and have a question about where to define the mutex.
Relevant information: the program has a
main.c where we determinate a specific action according to the user input. main calls a master_function which is located in a file named
master.c. In the
master.c file we create the N threads along some other actions (not relevant). The threads call a function named son_threads which is located in a
son.c file and they need to use a mutex when they enter enter a critical region (editing several global variable to prevent race condition). Another file I have is a
type.h where I define several global variables I need to use.
The declaration of mutex is:
pthread_mutex_t mutex1 = PTHREAD_MUTEX_INITIALIZER;
So I tried to define the mutex in my
type.h so it's visible to the
son.c files. When I try to compile it gives me error. Which is correct since I am defining that mutex in several files.
But I am pretty sure I cant define the mutex in the
son.c file because each time I create that thread, the mutex will be initialized to its default setting, not allowing me to use it properly. Not sure about this.
The mutex has to be a global variable, where the N threads have access to it. So where am I supposed to put it?
I dont know if I am explaining myself right. Trying my best.


text:
Speak with a Hat Expert
Se Habla Español
Youth Cotton Newsboy Cap
|The Jaxon Youth Cotton Newsboy Cap is a great basic cap to have in any wardrobe at any age! Now available in a youth size, the Jaxon Youth Cotton Newsboy Cap makes the classic style available to younger Approx.2" Snap Bill10" - 10 1/2" Diameter Made of:100% Cotton 8-Panel Cap w/ Center ButtonTonal Grosgrain Ribbon Sweatband Satin Lining Sizing: S/M and M/L, see fit below:S/M = 52CM M/L = 54CM
Child's Cotton Ivy Cap
|The Jaxon Child's Cotton Ivy Cap is both classic and charming. Made of soft cotton and lined in smooth satin, this dapper little cap is perfect for both casual and formal wear! Approx.1 7/8" Sewn Bill/Visor 8 3/4" Diameter Made of:100% Cotton Grosgrain Ribbon Sweatband Satin Lining Elasticized Back Sizing - Child S/M and M/L, see below: S/M = 52CM M/L = 54CM
Herringbone Newsboy Cap - Child
|Give your little one classic styling with the Jaxon Herringbone Newsboy Cap. The wool blend 8/4 cap is patterned with a charcoal herringbone and is detailed with a sewn bill, quilted satin lining and an elastic band that stretches to fit. Approx. 2 1/4 sewn bill Approx. 9" diameter Made of: 40% wool 60% polyester Quilted satin lining Elastic band for a comfortable fit Grosgrain ribbon sweatband Sizing: S/M = 52CM M/L = 54CM
INT'L: +1 619-906-4440 Se habla español
Shop for Hats at VillageHatShop.com | Privacy Policy | Site Map
Copyright © 1999-2015 Village Hat Shop: The #1 Source for Hats Online
* FREE SHIPPING offer valid for USA Ground service only.
Excludes wholesale/B2B and special orders.
Click Here
1 (888) 847-4287
7 Days a Week 8am-5pm PST


text:
This weekend Australian Boomers coach Andrej Lemanis was tasked with reducing the current 18-man Boomers' roster down to 12 players for the Rio Olympics. The team is set to be officially announced tomorrow morning, however, the final roster will include some surprise inclusions and see some veteran Boomers, considered "locks" by many at the beginning of camp, omitted from likely their last chance at making an...Read more
Brad Newley says "Goodbye" to Gran Canaria and "Hello" to Sydney?
Herbalife Gran Canaria confirmed Tuesday that Australian Boomers star Brad Newley will be ending his contract with the club on June 30. He has also informed the team he will not be returning next season. This should be no surprise to Aussie Hoopla readers who read that Newley had reached an agreement with the Sydney Kings over a month ago. Due to any basketball player being...Read more
Former NBL coach to take over Singapore National Team
Former NBL coach Frank Arsego has been named head coach of the Singapore National Men's Basketball team and will take over the team officially next month. He will also be taking on the role of technical director as part of a two-year contract. Arsego was coach of the Singapore Slingers during their time in the NBL from 2008-2010 and his knowledge of Singapore basketball was instrumental to him...Read more
Melbourne's Emmanuel Malou, the third Aussie to enter 2016 NBA draft
Emmanuel Malou has officially hired an agent and will forego his college eligibility in the hopes he can be selected in the 2016 NBA Draft.
It's not uncommon for college basketball stars to nominate for the draft in order to to gauge NBA interest. Basketball student-athletes can enter the NBA draft once during their college career without jeopardizing their eligibility as long as they do not sign with...Read more
Brad Newley becomes a Sydney King
Brad Newley will be suiting up for the Sydney Kings in 2016/17. Newley won't be announced as a signed player anytime soon however due to the rules on European players being only able to sign one contract at a time. This is the same situation the Adelaide 36ers find themselves in with Jerome Randle who is currently playing for Žalgiris Kaunas of the Lithuanian Basketball League. Joey Wright clarified...Read more
Ben Simmons Skips Draft Combine, Thon Maker Looks To Benefit From It
The NBA has released its official 2016 NBA Draft Combine list today. One name who isn't on the list of expected attendees is our own Ben Simmons. This shouldn't however be too much of a surprise to those keeping track. The NBA Draft Combine is a multi-day showcase which occurs every May before the NBA draft. It's purpose is to allow NBA coaches, general managers, and scouts...Read more
Former NBL Player David Patrick leaves LSU to coach at Texas Christian
David Patrick has been hired as an assistant coach on the staff of new TCU basketball coach Jamie Dixon. Patrick spent the past four seasons as an assistant at Louisiana State University. Patrick spent four seasons with the LSU Tigers and helped the staff secure two top-five recruiting classes, including last year's, which featured top prospect Ben Simmons, his godson. During his four years in Baton Rouge, Patrick...Read more
Ben Simmons Won't Play For Australia In Rio
Ben Simmons has made it known that he will not be wearing green and gold in Rio this year. The conversation around whether Ben Simmons will be able to juggle both NBA commitments and the NBA draft process has been a hot topic. Today Ben Simmons decision made it clear to Basketball Australia. The report came from ESPN's Chris Broussard, who quoted Simmons' agent, Rich Paul, who confirmed Simmons will...Read more
Patty Mills in career form heading into Playoffs, Rio
This season has seen Australian Boomers guard Patty Mills who is having his most efficient season ever for the San Antonio Spurs. Taking a glance at Mills' numbers won't allow you to see the real impact he is having in the league this year. With career averages of 7.5 points, 1.8 assists, and 1.5 rebounds per game this season Mills has carved a clearly defined role within the...Read more
Australian Basketball Players Overseas
Australian Basketball has truly exploded around the world in recent years and many of our best basketball players now play in the NBA, Euroleague and College on a regular basis. Names like Andrew Bogut, Patrick Mills, Matthew Dellavedova and Joe Ingles are well known within the Australian Basketball community however on our last count we had...Read more


text:
"Ghostbusters": 11 Things the Sequel Needs to Do to Succeed
The Eclectic Micks are a group of Irish comic artists who have set up a group sketch blog featuring all kinds of cool artwork. And this week, with the launch of IDW's new Tranformers miniseries, Last Stand of the Wreckers (collective member Nick Roche draws the series), they've temporarily changed their name to Eclectic Wrecks and are running sketches of characters from the series. If you're into the Transformers, go check'em out.
That's "Last Stand of the Wreckers."
Really great stuff. I am a part of an American cartoonist group that does a similar thing…check it. http://sketchyscribbles.blogspot.com/


text: kyle.stankiewicz Play via YouTube OPEN IN APP NSFW Safe Is this playlist safe for work? Pumped Up Hip-Hop May 21, 2012 | 18 tracks | 1,096 36 | Stats Jedi Mind TricksAtmosphereT.I. raphip hopuptempohard Liked Collect Share Edit Liked! Share this mix with friends: Pumped Up Hip-Hop Wrong video Collect Share Liked! Share this mix with friends: