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'In Silico' Simulation of Biological Processes No. 247 / Edition 1by Novartis Foundation, Novartis, Novartis Foundation Symposium
Pub. Date: 12/27/2002
Publisher: Wiley
Over recent decades vast amounts of biological data have been accumulated. However, it is becoming increasingly difficult to apply traditional theoretical methods to the formulation of coherent pictures of cell and organ function because it is no longer possible for a human theorist to integrate all of the available information. Instead, computer technologies must
Over recent decades vast amounts of biological data have been accumulated. However, it is becoming increasingly difficult to apply traditional theoretical methods to the formulation of coherent pictures of cell and organ function because it is no longer possible for a human theorist to integrate all of the available information. Instead, computer technologies must now be used to perform this integration. This book brings together contributions from many different fields to summarize the current status of computer-assisted modelling of biological processes.
The initial chapters deal with fundamental developments in hardware, software and mathematics that underlie current approaches to biological modelling. Next, different approaches to collating data on gene structure and function are presented. These databases form a vital resource for any investigator trying to construct an integrated picture of particular biological systems.
Cell signalling systems form a particularly complicated aspect of all cellular function and are important both in the understanding of basic cellular processes and in selecting targets for drugs. Recent approaches to integrating data on cell signalling into computer models are covered. Further chapters build on these approaches to show how computerized models of intact cells can be developed. Finally, approaches to the computer modelling of whole organs such as the heart are presented. The role of computer modelling in drug design is the subject of the final chapter and is also touched on throughout the discussions.
Product Details
- 9780470844809
- Publisher:
- Wiley
- Publication date:
- 12/27/2002
- Series:
- Novartis Foundation Symposia Series
- Pages:
- 270
- Product dimensions:
- 6.20(w) x 9.39(h) x 0.70(d)
Table of Contents
Chair's Introduction (D. Noble).
Integrative biological modelling in silico (A. McCulloch and G. Huber).
Advances in computing, and their impact on scientific computing (M. Giles).
From physics to phenomenology: Levels of description and levels of selection (D. Krakauer).
Making sense of complex phenomena in biology (P. Maini).
On ontologies for biologists: the Gene Ontology—untangling the web (M. Ashburner and S. Lewis).
General discussion I: Model validation.
The KEGG database (M. Kanehisa).
Shanka Subramaniam and the Bioinformatics Core Laboratory Bioinformatics of cellular signalling.
General discussion II: Standards of communication.
Semantics and intercommunicability.
Imaging-based integrative models of the heart: closing the loop between experiment and simulation (R. Winslow, et al.).
General discussion III: Modelling Ca2+ signalling.
The Virtual Cell project (L. Loew).
Modelling the bacterial chemotaxis receptor complex (T. Shimizu and D. Bray).
The heart cell in silico: successes, failures and prospects (D. Noble).
General discussion IV.
The IUPS Physiome Project (P. Hunter, et al.).
Using in silico biology to facilitate drug development (J. Levin, et al).
Final discussion: Is there a theoretical biology?
Index of contributors.
Subject index.
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French culture, customs, and etiquette can often feel very formal to Anglophones, leaving many feeling uncomfortable or a tad offensive. Here is a quick rundown of some essential faux pas to avoid and do your best to fit in en France. 1. No bread on the plate (and don't butter your bread!) You will always be served breadRead More
Famous Parisian Cafés
There is perhaps no place more beloved or revered in French culture than the café. For the French, the café is more than a simple spot to grab coffee – it's a meeting point for discussions with old friends, an opportunity to read Le Monde and reflect, a corner table to work on your developing novel,Read More
Lavender: The Beauty of Provence Inside and Out
Vibrant violaceous lavender blooms sweeping the arid fields of Provence is one of the most emblematic postcard images of France—and extends to the point of legend. The story goes that a young girl named Lavandula was dismayed when she saw the wasted bounty of the Lubéron land and her resulting teardrops were scattered across the region, sprouting to formRead More
Five Ways to Sound More "French"
Many French students remark upon their first visit to France that spoken French is very different from what they have been taught in school. Indeed, spoken and informal French make major departures from the formal way of writing and speaking that is taught in French lessons. So, if you want to "sound more French" and when you speak,Read More
Discovering the Périgord
The Périgord region is a traditional French province in southwest France that now is mostly contained in the département of Dordogne. Renowned for its cuisine (particularly its truffles, confit de canard, and foie gras) and wines (red and white Bergerac and Monbazillac), it is also known for its lush, natural setting and abundant wildlife. Many may also be familiarRead More
The Raw Truth About Steak Tartare
Steak tartare, a dish made from minced or chopped raw beef mixed with a variety of spices and sauces, is a staple on classic French bistrot menus. While this divisive dish makes some go miam ("yum") and others go beurk ("yuck"), it holds mythic status in France, in addition to being the center of many misconceptions. This classicallyRead More
Back to school: La rentrée littéraire 2015
"La rentrée" is a magical season in France. Just as the autumn air grows crisp, the French emerge bright-eyed and bushy-tailed from long vacations at the seaside and in the mountains, ready to embark on a new school year and geared up to get back to work. La rentrée also marks the start of the cultural seasonRead More
NightSwapping: Traveling for the Culturally Curious
Have you ever wanted to travel the world and experience each culture authentically? A new company called NightSwapping has answered your prayers! In an age where you can cross the Atlantic in six hours, NightSwapping is giving travelers the opportunity to experience different cultures from an alternate perspective. I had the pleasure of interviewing Joshua Hibbard, Press Relations Officer for theRead More
La Cornuelle: One Cool Cookie
If you thought French pastries solely consisted of croissants, beignets, and éclairs, then think again! It turns out that these culinary French staples are not the only ones to get excited about — each region of France has its own specialty. Today, however, we are looking at one traditional baked good hailing from the commune ofRead More
Join Us Sunday for La Fête de la Musique in Dupont Circle
It's summertime in France – picnics begin on the Seine; lavender blossoms in the south; the beaches on the Côte d'Azur fill up with les français and tourists alike. In June, all French eyes turn to one cultural phenomenon – la fête de la musique. Transforming cities across l'hexagone with a slew of music-driven festivals,Read More
Northern Lights: Chartres en Lumières 2015
Even with extended daylight hours of summer, the town of Chartres will not be leaving anyone out in the dark. The annual Chartres en Lumières (Chartres in Lights) festival kicked off on April 11th. Every evening from April to October, the French city of Chartres highlights its natural and historical heritage, illuminating 29 cultural and architectural sitesRead More
Off the Beaten Path: Discovering Île de Ré
Île de Ré, a small island located off of France's Northern Atlantic coast, near the port of La Rochelle, is a long-popular beach holiday destination for the French, although not as widely known abroad. This island, famous for its huîtres (oysters), crevettes impériales (among some of the most famous shrimp in the world), organic local beer,Read More
The Cannes Film Festival is now underway, running from May 13 to May 24, the glitterati of the world of cinema have now descended on the quiet city on the Côte d'Azur. On April 16th, the initial Official Selection of films nominated for the Palme d'Or, the highest honor awarded at the Cannes Film Festival,Read More

subset: commoncrawl


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This paper describes the process feasibility analysis and numerical simulation of Ge implanted SiGe-channel p-MOSFETs. The average separation between conducting holes and SiO2-Si interface peaks at certain effective implantation range, implies an optimum mask thickness. Threshold voltage is shown to increase with increasing Ge dose and decreasing effective projected range


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- Can renewable energy save the world? Not without better batteries(voxeu)
- Breakthrough Inventions and Migrating Clusters of Innovation (NBER)
- Happy Anniversary Wall Street (Keen)
- Lego's business comes to boom (CNBC)
- Foodservice Traffic Declines for Fourth Consecutive Quarter (NPD)
- Chinese railways and speculating pig farmers (Pettis)
- The myth of uncorrelated returns (CFA Institute)
Latest Stories
Readings: Energy, Lego, Pig Farmers, etc.
By October 29, 2009 · ··


text: How Many Different PSP Poses Can You Strike in Skimpy Clothes?Brian Ashcraft6/05/12 6:30amFiled to: ChinaKotakueastPSP139EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalink In China, there's a whole subgenre of tech models who specialize in wearing skimpy clothes and posting with electronics. According to Liu Youqi's profile, she's not one of those, but rather, a cosplayer.Her photos beg to differ. The model, who also calls herself "Sevenbaby", shows how you can pose with hardware, while not looking like you are actually playing it—looking like you are just being with it. A master class in PSP posing. "童颜巨乳" [Game.163] Reply139 repliesLeave a reply


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I know some FPGA board might have the Ethernet port. However, how could I connect an FPGA board to the internet to receive and decode TCP/UDP packets? Basically, I would like to receive some data from a server through TCP or UDP and process it on the board.
We started with Q&A. Technical documentation is next, and we need your help.
Whether you're a beginner or an experienced developer, you can contribute.
closed as too broad by Andrew Medico, Tom Zych, Cupcake, Chris McFarland, josliber♦ Jul 10 '14 at 0:12
There are either too many possible answers, or good answers would be too long for this format. Please add details to narrow the answer set or to isolate an issue that can be answered in a few paragraphs.If this question can be reworded to fit the rules in the help center, please edit the question.
Easy. Add a softcore processor (e.g. Nios2 or Microblaze), an OS with a TCP/IP stack (eCos, Linux, uCosII, etc.) and maybe a web server.
You'll need an ethernet PHY, of course, but even the ethernet MAC can be soft IP.
If you want to avoid a software solution, you could also use some kind of TOE (TCP Offload Engine) and put the entire TCP/IP stack in hardware on the FPGA.
Yes as long as the necessary hardware (=phy) is on board, its no problem. One solution would be to process them with a softcore. But you could also process them direct in hardware. But be carefull a full TCP stack is very hard to implement in hardware, udp is no problem. E.g. one project there is NetFPGA.


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LCBHMMGS7/442401000627000_MEDIA_SET true
Remo FiberSkyn 3 Simulated Calfskin Medium Bass Head 40 in.Product #442401 Remo 442401 LCBH Concert Drum Heads https://www.esnapw.com/rses/ESnapServlet?MerchantNumberSent=63655
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Field adjustable from 8 to 11.5 inches. Covers a standard 3 to 4 inch junction box.
The stunning glass from Bruck Lighting is hand-blown in various locations across the globe, including Italy, Austria, Germany and the United States. Professional glass making, which originated during the Roman Empire, is a painstaking process where only true perfection is accepted, and the rejected pieces are broken up and recycled. All of our glass artisans are highly experienced and gifted in the art of glass making. These artisans choose only top quality glass batches to ...
NOTICE: This item requires professional installation by a licensed electrician. Titan 2 is offered in matte chrome, chrome or bronze and is compatible with any Bruck low voltage or line voltage track with adapter, as well as Halo® single circuit for retrofit. The elegant Titan 2 can be mounted from Bruck's field adjustable, 4-Inch Kiss Canopy, and accepts CFL or medium base lamping options. Standard cable length of 59-Inches can be field-cut. Matte White Glass ...
Field adjustable from 5 to 118 inches. Covers a standard 3 to 4 inch junction box.
Covers a standard 3 to 4 inch junction box.
The V/A Canopy Power Feed for the V/A track, is capable of supplying up to 300W to a single circuit track segment. Stem rod length may be field cut. The V/A Dual Rod Power Feed covers standard junction box. The minimum adjustable height for this power feed is 2 .375-Inch.
Non-conductive connector that joins two Enzis track segments together while splitting into 2 circuits.


text:
Biker Gang Attackers Still Out There, Waiting to Beat Someone Else Up
The NYPD is looking for four more.By Joe Coscarelli
The NYPD is looking for four more.By Joe Coscarelli
And it had to be "hot."By Joe Coscarelli
The cause was suicide.By Adam Martin
Thanks to a random check three years ago.By Adam Martin
The New York Post looked into it.By Caroline Bankoff
The eighties are back, sort of.By Caroline Bankoff
Drunken driving takes up a lot of ink.By Caroline Bankoff
"Thousands of dollars of losses on more than 50 accounts."By Adam Martin
He's a professional boxer.By Joe Coscarelli
We can't quit you, Banksy.By Joe Coscarelli
But will it hold up?By Adam Martin
"You don't know who you're doing this to!"By Adam Martin
Sweet vindication.By Joe Coscarelli
To "gain focus and insight."By Halle Kiefer
"Where did you get that shiner, kid?"By Joe Coscarelli
And he's no longer facing felony charges.By Delia Paunescu
He was reportedly unhappy with his relatives' success.By Joe Coscarelli
They were legal in Tennessee, but not here.By Adam Martin
He's facing felony assault charges.By Delia Paunescu
Their 25-year-old relative is in custody.By Margaret Hartmann


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Top Definition
A clause in an GI's contract allowing the government to hold you past your ETS date for war or other national emergencies to keep your unit at or near 100% strength. In the case of a deployment they can hold you up to 90 days after redeployment but a Liutenant Colonel or higher can release you earlier if you finish outprocessing sooner than 90 days. It's simular to stop movement but that stops you from PCSing to another unit.
Stop loss wasn't even thought about a few years ago to new recruits and now thousands of soldiers in the army cant go home on thier ETS dates because they're either facing a one year tour to Iraq or Afganistan soon or they're already over there
by GI Bro July 11, 2004
Trending Now


text: Enormous LEGO Metal Gear Rex Is Looking For Tiny Plastic Men To CrushLuke Plunkett1/17/13 10:00pmFiled to: Metal GearMetal Gear SolidLegoToys25EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalink Not to be outdone by a toy company selling models that are already finished, LEGO builder Rags naRock has his own version of Metal Gear Rex to share. And I dare say it's more impressive. Using around $900 worth of LEGO parts, the thing is enormous, and if the scale isn't enough to knock your socks off it moves as well. The link below not only has more pics of the Rex in action, but instructions to download so you can try building one yourself. Advertisement Metal Gear Solid REX V.2 [mocpages, via ALBOTAS] Reply25 repliesLeave a reply


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Foam Tool Kit (18"x36") for Tool Organization
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Disorders of Personality: Introducing a Dsm / ICD Spectrum from Normal to Abnormal
Like its predecessor, the Second Edition guides the reader through the special complexities of this group of disorders and aids clinicians in the difficult work of diagnosis. It serves as an indispensable companion volume to DSM-IV [superscript TM], especially in the light of advances that have transformed personality disorders from an area of marginal relevance in diagnos ...more
ebook, 912 pages
Published April 8th 2011 by Wiley
(first published 1981)
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Apr 27, 2012 Ashlea rated it it was amazing · review of another edition
Absolutely the most informative and updated version of any book regarding personality disorders; "a must read"
Jul 22, 2008 kevin rated it it was amazing · review of another edition
thus far i've learned that we're all far more disordered than i would've hoped ... the curse, i suppose, of too much information combined with too much observation and extrapolation.
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DPS Incorporates Tuition-Free Montessori Programs Into Some SchoolsThe district has begun taking applications for early childhood (ages 4-6) and early elementary age students for certain schools.
Michigan Uses Well-Worn Tactic In Shifting Tobacco CashTo rescue Detroit's school district from potential insolvency, Michigan is turning to a familiar playbook.
Another Former Detroit Principal Enters Plea In Bribery CaseWillye Pearsall is accused of taking $50,000 in kickbacks from Norman Shy and his Allstate Sales.
$390K Settlement Reached For Broom-Wielding Detroit TeacherThe 9th grade teacher was fired in 2014 after she used a broom to break up a fight between students.
Bailout Of Detroit Schools Moves Forward In LegislatureLegislators have 28 days to strike a deal before emergency aid previously approved for the district will run out.
House Passes $617 Million Detroit Schools PlanThe Michigan House has narrowly approved compromise legislation to restructure the Detroit Public Schools and pay off $617 million in debt.
Michigan House May Vote On $617 Million For Detroit SchoolsThe bills would retire the district's enormous $467 million operating debt over time and provide $150 million to transition to a new district in July.
Advocates Spar On Mackinac About Charter Rules In Detroit Schools OverhaulAdvocates at a major policy meeting are sparring over new oversight of Detroit charter schools as part of a multi-million state bailout of the city's ailing K-12 district.
Detroit Public Schools Announces Academic Advisory CouncilSuccessful models in use elsewhere could be implemented in Detroit.
Detroit Students Invite President Obama To Visit Schools, See Problems First-HandThe students think a visit from Obama will not only accelerate help for the district, but it would give the community hope and a sense that they're not alone.
Security Video Shows Alleged 'Police Brutality' Against Female Student Inside Detroit's Cass Tech [VIDEO]A security video filmed in the halls of Detroit's largest high school is causing shock among the community.
Detroit Schools To Defer Start Of Employee Contract TalksThe Detroit Federation of Teachers says it's disappointed.


text:
Learn how MacUpdate Desktop can install apps on MacUpdate with the simple click of the icon. Plus, keep all your apps updated.
DisplayCAL is a graphical user interface developed by Florian Höch for the display calibration and profiling tools of Argyll CMS, an open source color management system developed by Graeme Gill.
Calibrate and characterize your display devices using one of the many supported hardware sensors, with support for multi-display setups and a variety of available settings like customizable whitepoint, luminance, tone response curve as well as the option to create matrix and look-up-table ICC profiles, with optional gamut mapping, as well as some proprietary 3D LUT formats.
Other Features
- Support of
What's New
- A fourth Rec. 709 encompassing color space variant as a profile connection space candidate for XYZ LUT profiles. May lead to better utilization of PCS-to-device color lookup table grid points in some cases (and thus potentially smaller profiles when the effective resolution is set to the default of "Auto").
- An option to include legacy serial ports (if any)
- OS X 10.5 or later


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- Choosing acne cleansers and face soaps.
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Dr. Ravins graduated from the Thomas Jefferson University, Jefferson Medical College in 1991. She works in Rego Park, NY and 1 other location and specializes in Obstetrics & Gynecology. Dr. Ravins is affiliated with Forest Hills Hospital, New York Community Hospital, North Shore University Hospital, Northwell Health Long Island Jewish Medical Center and South Nassau Communities Hospital.
Obstetrics & Gynecology
Medical School: Thomas Jefferson University, Jefferson Medical College; Graduated 1991
Please verify insurance information directly with your doctor's office as it may change frequently.
*This physician has multiple office locations. See Office Information for details.
6231 Cromwell Cres
Rego Park, NY 11374
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|Publication number
|Publication type
|Application number
|Publication date
|Sep 7, 1976
|Filing date
|Jan 21, 1974
|Priority date
|Dec 30, 1971
|Publication number
|Richard Newton Lewis
|Original Assignee
|Sws Silicones Corporation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (11), Referenced by (20), Classifications (26), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a divisional application of application Ser. No. 214,406, filed Dec. 30, 1971, now U.S. Pat. No. 3,799,962.
This invention relates to alkoxysiloxanols and more particularly to alpha-alkoxy-omega-siloxanols. Such materials contain one relatively more reactive group (OH) and one relatively less reactive group (alkoxy); for this reason they have long been sought as intermediates in the synthesis of siloxanes. They have not, however, been available by any process known heretofore.
Several processes that might have been expected to lead to alkoxysiloxanols have instead produced other products. For example, linear and cyclic methylpolysiloxanes heated with methanol in the presence of potassium hydroxide gave instead trimethylalkoxysilanes and dimethyldimethoxysilanes (U.S. Pat Nos. 3,746,982 and 2,826,599). Cyclic trisiloxanes heated with n-octyl alcohol and toluenesulfonic acid in xylene gave dioctyloxytrisiloxanes and water as the principal products, even when the reaction was stopped at an early stage. [ See Sprung and Guenther J. Org. Chem. 26, 552 (1961)].
It is another object of this invention to provide alkoxysiloxanols. Another object of this invention is to provide alpha-alkoxy-omega-siloxanols. It is also an object of this invention to provide a method of producing alpha-alkoxy-omega-siloxanols in high yield and in a high state of purity. It is a further object of this invention to provide novel antistructure agents, coupling agents and filler-treating agents.
These objects, and others which will become apparent from the following description, are achieved, generally speaking, by contacting a cyclic polysiloxane with an alcohol having up to 20 carbon atoms under relatively mild conditions to form a compound of the general formula R'O(R2 SiO)x H, wherein R and R' are organic radicals and x is an integer of at least 2 and preferably from 2 to 10. In some cases satisfactory results are obtained without a catalyst. In other cases it is advantageous to employ a weak base of a weak acid as a catalyst.
The cyclic polysiloxanes that may be used in the practice of this invention have the general formula (R2 SiO)y. The radicals represented by R in this formula are hydrocarbon radicals, halogenated hydrocarbon radicals or cyanoalkyl radicals having from 1 to 8 carbon atoms. Suitable radicals include alkyl radicals such as methyl, ethyl, propyl, butyl, or hexyl and fluorinated derivatives thereof; alkenyl radicals such as vinyl or allyl; and aryl radicals such as phenyl or tolyl and chlorinated derivatives thereof. It is preferred that at least half of the radicals be methyl radicals. Very good results are obtained it all of the radicals are methyl.
The number of units, y, in the cyclic polysiloxane is at least 3 and may be as high as 10. Generally the fastest and cleanest reaction occurs when y is 3. However, very good results are also obtained when y is 4 5 5 or even more. Suitable cyclic polysiloxanes thus include those of the general formula [ (CH3)2 SiO]y, where y is from 3 to 10, particularly when y is 3, 4 or 5. Other cyclic polysiloxanes that may be used include those having groups other than methyl; for example, trimethyltrivinylcyclotrisiloxane, tetramethyltetravinylcyclotetrasiloxane,, heptamethylvinylcyclotetrasiloxane, trimethyltriethylcyclotrisiloxane, trimethyltriphenylcyclotrisiloxane, hexaphenylcyclotrisiloxane, and the like.
Alcohols of almost every description may be used in the practice of this invention. Long-chain or short-chain alkyl, cycloalkyl, alkenyl and aralkyl alcohols and substituted derivatives thereof having up to 20 carbon atoms, including allyl alcohol and benzyl alcohol may be used. Substituted alcohols such as ethanolamine, 2-methoxyethanol, and 2-chloroethanol may also be used. Best results are usually obtained with the short-chain primary and secondary alcohols having up to 4 carbon atoms, e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, or isobutyl alcohol. The cleanest and fastest reactions, with fewest side reactions, occur with methyl alcohol.
The general reaction may be expressed by the equation R'OH + (R2 SiO)y→R'O(R2 SiO)x H. In this equation R' represents the radical of an alcohol having up to 20 carbon atoms. Generally x is equal to y. Under certain conditions, x may have values greater than or less than y. It is preferred to work with a large excess of the alcohol, or the reaction may be very slow. Mole ratios of alcohol to cyclic polysiloxane should be between 2:1 and 50:1, preferably at least 5:1. Ratios higher than 50:1 may be employed, but offer no special advantage.
Reaction temperature is not critical. A reasonable rate of reaction can usually be achieved at room temperature or below. Often it is preferred to operate at somewhat higher temperatures, but generally not much over 100�C. The reflux temperature of the alcohol is ofen a satisfactory operating temperature. If higher temperatures are desired, the reactions may be conducted under moderate pressure, but this is not usually necessary.
In some instances, as in the reaction of methanol with a cyclic trisiloxane, no catalyst is required, and the reaction proceeds at a satisfactory rate as the reflux temperature of the methanol.
When a catalyst is desired a weak acid or a weak base may be added, as indicated above. Strong acids such as toluenesulfonic acid and strong bases such as sodium methcxide are commpletely unsatisfactory as they caue unwanted cleavage and equilibration reactions. Even moderately strong acids such as oxalic acid (pKa 1.23) cause rapid decomposition of the alkoxysiloxanol that is produced and are of borderline utility. For optimum utility the catalyst should have a pKa or pKb above 1.5, corresponding to an acid or basic dissociation constant below 0.03. Maleic acid (pKa 1.83) and phosphoric acid (pKa 2.12) are about the strongest acids that can be used with saftey. Even so they must be quickly neutralized when the desired reaction has been essentially completed. In general, any organic or inorganic acid or base may be used if its pKa or pKb lies between 1.5 and 10. Extremely weak acids or bases with pK values above 10 are relatively ineffective.
In order to eliminate the neutralization step, it is advantageous to use an acid or base that is volatile, so that it can be removed by distillation. A catalyst that decomposes into harmless by-products on heating is also desirable. Suitable acid catalysts include formic acid (pKa 3.75), acetic acid (pKa 4.75), propionic acid (pKa 4.87), malonic acid (pKa 2.83), succinic acid (pKa 4.16), and cyanoacetic acid (pKa 2.45).
Suitable bases include the primary, secondary, and tertiary aliphatic amines, which have pKb values in the range of about 1.95 (diisopropylamine) to 4.26 (trimethylamine); ammonia (pKb 4.75); ethanolamine and its alkyl derivatives; pyrrolidine, piperidine, and their homologs; morpholine (pKb 5.4), N-methylmorpholine (pKb 6.5), and N-ethylmorpholine (pKb 6.2); ethylenediamine (pKb 4.07) and its n-alkyl derivatives; piperazine (pKb 4.1) and dimethylpiperazine (pKb 5.8); pyridine (pKb 8.77); and aromatic amines such as dimethylamine (pKb 8.94). Ammonia and the more volatile amines are particularly preferred because of their easy removal.
Salts of weak acids and bases may also be used, but they are less easily removed than the acids and bases listed above, and are therefore not usually preferred.
The catalysts listed above are effective at relatively low concentrations. Concentrations up to five percent may be used, but the preferred range is from 0.01 to 1.0 percent.
In order to purify the alkoxysiloxanols the excess of alcohol is removed by distillation at atmospheric or reduced pressure. Unreacted cyclic polysiloxane, if any, is best removed by vaccum distillation. The alkoxysiloxanol left in the distillation pot at this stage is often pure enough for most purposes. Further purification, if desired, may be achieved by distilling the alkoxysiloxanol at reduced pressure. Products of essentially 100 percent purity can thus be obtained.
The alkoxysiloxanols of this invention are useful as chemical intermediates, as antistructure agents in silica-filled elastomers, and as agents for reducing the surface reactivity of inorganic fillers, especially siliceous fillers. Suitably treated fillers may be obtained by heating untreated fillers with alkoxysiloxanols, preferably in the range of 50� to 200�C. The hydrophobic fillers thus obtained are very useful in the preparation of high-strength silicone elastomers.
Alkoxysiloxanols that contain vinyl groups, e.g. 5-methoxytrimethyltrivinyltrisiloxan-1-ol, are particularly useful as coupling agents between inorganic materials such as fillers and fibrous reinforcing agents, e.g. glass fibers, and organic polymers, especially those that are cured by free-radical or vinyl-addition reactions. Examples include silica-reinforced elastomers of various types and glass-reinforced polyesters.
The following examples are offered by way of illustration, but not by way of limitation. In these examples the dimethylsiloxane unit, (CH3)2 SiO, is represented by the symbol D, and the methylvinylsiloxane unit, CH3 C2 H3 SiO, is represented by the symbol Dv. All parts are by weight unless otherwise specified.
Hexamethylcyclotrisiloxane (D3) (22.2 parts) was dissolved in 120 parts of methanol and heated at reflux for four hours. Analysis by gas chromatography showed, in addition to methanol, 91.0 percent 5-methoxy-hexamethyltrisiloxan-1-ol (CH3 OD3 H), 7.5 percent unreacted D3, and 1.5 percent 3-methoxy-tetramethyldisiloxan-1-ol (CH3 OD2 H), the latter indicating a slight amount of additional cleavage of the trisiloxanol. There was no evidence of symmetrical siloxanes such as dimethoxytrisiloxane or a trisiloxanediol. On distillation at reduced pressure a nearly pure fraction of CH3 OD3 H was obtained boiling at 86�C. (15 mm). Absorption in the near infrared showed strong, sharp OH peaks at 2700 nm. and 2900 nm. Nuclear magnetic resonance showed the group ratios CH3 (Si) 6.0, CH3 O 1.1, OH 1.0; theoretical 6:1:1.
Ten parts of 1,3,5-trimethyl-1,3,5-trivinylcyclotrisiloxane (Dv 3) was mixed with 70 parts of methanol and 0.35 part of formic acid and allowd to stand at room temperature for 4 days. The methanol was then removed under vacuum below room temperature, and the remainder was distilled at 1.6 mm., giving 8.1 parts of a product boiling at 78�-89�C. Analysis by gas chromatography of the product showed 7.6 percent of 3-methoxy-1,3-dimethyl-1,3-divinyldisiloxan-1-ol (CH3 ODv 2 H), 21.5 percent of Dv 3, 68.9 percent of 5-methoxy-1,3,5-trimethyl-1,3,5-trivinylsiloxan-1-ol (CH3 ODv 3 H), and 2.0 percent of CH3 ODv 4 H.
Octamethylcyclotetrasiloxane (D4) (11 parts) was heated to reflux with 60 parts of methanol and 0.4 part of formic acid for 16 hours. Gas chromatographic analysis showed 29.7 percent of 7-methoxyoctamethyltetrasiloxan-1-ol (CH3 OD4 H), 1.0 percent of CH3 OD3 H, 0.1 percent of CH3 OD2 H, 68.7 percent of unreacted D4, and 0.5 percent of a volatile compound, possibly CH3 ODH. The rate of formation of CH3 OD4 H is thus about 2 percent per hour at 65�C, with very little by-product.
One part of decamethylcyclopentasiloxane (D5) was mixed with 6 parts of methanol and 0.07 part of cyanoacetic acid and kept at room temperature for 48 hours. At the end of this time 6.7 percent of the D5 had been converted to 9-methoxydecamethylpentasiloxane-1 -ol (CH3 OD5 H) with no by-products detectable at a level of 0.02 percent. This is a conversion of 3.4 percent per day.
A similar reaction was carried out with 0.15 part of di-n-butylamine. A smaller amount of CH3 OD5 H was produced, along with significant amounts of CH3 OD4 H, CH3 OD3 H, and CH3 OD2 H. In this example the acid catalyst appears to give fewer by-products.
One part of D3 was mixed with 7 parts of ethyl alcohol and 0.05 part of formic acid at room temperature. In six hours gas chromatography showed the following (in addition to ethyl alcohol): unreacted D3 71.0 percent, C2 H5 OD3 H 18.3 percent, a more volatile by-product 3.8 percent, and a less volatile byproduct 6.9 percent.
Eleven parts of D3, 60 parts of n-propyl alcohol and 0.4 part of formic acid were heated at reflux (95�C.) for 1 hour, producing a major amount of C3 L7 OD3 H and minor amounts of two less volatile materials.
Eleven parts of D3, 60 parts of methanol, and 0.6 part of acetic acid were heated at reflux (65�) for 2 hours. At this time 98 percent of the D3 had been converted to CH3 OD3 H, with only traces of by-products (CH3 OD2 H and CH3 OD4 H). In comparison with a similar reaction without a catalyst (Example 1) it is clear that the reaction in the presence of acetic acid is not only faster but produces fewer-by-products.
Example 7 was repeated with 0.4 parts of formic acid in place of acetic acid, and the reaction was about 96 percent complete in 12 minutes, again with practically no by-products. When reflux was continuted for 90 minutes, small amounts of CH3 OD2 H, CH3 OD4 H and CH3 OD6 H were formed.
Example 7 was repeated with 0.5 part of N,N'-dimethylpiperazine as a catalyst. The reaction was 80 percent complete in 10 minutes with only traces of by-products. After 2.5 hours of reflux significant amounts of CH3 OD2 H, CH3 OD4 H, CH3 OD5 H, and CH3 OD6 H were formed, CH3 OD3 H still being the major product.
Solutions of 9 parts of D3 in 60 parts of methanol were prepared at room temperature. To these were added 0.5 part of cyanoacetic acid, 0.15 part of ammonia, and 0.3 part of di-n-butylamine. All were effective catalysts and produced 90 percent yields of CH3 OD3 H in less than 30 minutes. In each case significant by-products appeared only after several hours.
Identification of the minor ingredients in the above examples (1 - 12) was made on the basis of gas chromatography. A Varian Aerograph Model 700 Gas Chromatograph was used. The column used has the following description:
______________________________________Material: Stainless steelDimensions: 5 feet � 1/4 inch O.D.Liquid phase: Dimethyl silicone gum (SE-30), 30 percent.Solid support: 70 - 80 mesh acid-washed dimethyldichloro- silane-treated firebrick (Gas-chrom RZ), 70 percent.Helium flow: 60 ml./min.______________________________________
The reaction times given below are those actually measured. They were reproducible within 1 percent using the above column, although another column might have given somewhat different values. However, the important consideration is relative, rather than absolute retention times. Thus it is known that in a homologous series the ratio of retention times is constant from one member to the next.
______________________________________Retention Times at 170�C.a Retention Time,Compound Minutes Ratiob______________________________________D3 1.35 --D4 2.80 2.07D5 5.83 2.08D6 12.70 2.18 Average ratio for D Cyclics 2.11CH3 OD2 H 1.46 --CH3 OD3 H 3.24 2.24CH3 OD4 H 6.09 2.13CH3 OD5 H 14.08 2.15CH3 OD6 H 31.02 2.11CH3 OD7 H 64.00 2.06 Average ratio for CH3 ODx H 2.14HOD3 H 3.43CH3 OD3 H 3.24 0.94C2 H5 OD3 H 4.08 1.26C3 H7 OD3 H 5.05 1.35______________________________________ a Retention times relative to air. b Retention time divided by that of next lower homolog.
It is evident from the data above that the effect of an added D unit in a methoxysiloxanol is almost identical to its effect in the known series of cyclic siloxanes. This regularity provides an invaluable aid to identification. The same is not true in the series HOD3 H, CH3 OD3 H, C2 H5 OD3 H, C3 H7 OD3 H, in which the homologous change involves a relatively small part of the molecule
______________________________________Retention Times at 190�C. Retention Time,Compound Minutes Ratio______________________________________Dv 3 2.52 --Dv 4 6.08 2.42Dv 5 14.77 2.43CH3 ODv 2 H 2.0 --CH3 ODv 3 H 5.38 2.69CH3 ODv 4 H 13.04 2.45______________________________________
A. One hundred parts of a silicone gum (containing 0.1 percent of methylvinylsiloxane) was mixed with 10 parts of CH3 OD3 H and 36 parts of fumed silica (Cab-O-Sil Hs-5) in a Sigma mixer at 250�F. No difficulty was encountered and a smooth compound was obtained.
B. A similar compound was prepared with only 6 parts of CH3 OD3 H. Some mixing difficulty was encountered, but a smooth compound was eventually obtained.
C. A reference compound was prepared from 100 parts of the same gum, 16 parts of a standard "softener" (antistructure agent) commposed of a linear polydimethylsiloxane containing 2.5 percent of OH groups, and 36 parts of Cab-O-Sil HS-5. Attempts to prepare similar compounds with less than 16 parts of the standard softener were unsuccessful because of structure build-up. Thus it is apparent that CH3 OD3 H is approximately twice as effective, on a weight basis, as the standard softener.
Samples of each of the above were successfully cured by heating with dichlorobenzoyl peroxide (1.1 percent of a 50-percent paste, 5 minutes at 240�F.). The following physical test data were obtained after a 16-hour postcure at 450�F.
______________________________________ A B C______________________________________Hardness, Shore A 43 52 50Tensile strength, psi 1200 1000 1100Elongation, percent 475 400 500Compression set(ASTM D395 Method B) 23 18 30______________________________________
It can be seen from these data that the physical properties are approximately equivalent, in general. However, the better (lower) compression set values of the elastomers containing the methoxysiloxanol are clearly evident.
Six drops of CH3 OD3 H were applied to the surface of a clean glass plate. After 10 minutes at room temperature the surface was washed off with acetone and found not be water repellent. A second glass plate was treated with six drops of CH3 OD3 H and heated 15 minutes at 105�C. The liquid had evaporated and the surface was found to be somewhat water repellent; water drops on the surface formed a contact angle of about 60�. A third glass plate was treated with 6 drops of CH3 OD3 H and heated for 30 minutes at 150�C., whereby it became water repellent; water drops formed contact angles of about 70� on the surface.
A fumed silica (Cab-O-Sil MS-7) was mixed with one tenth its weight of CH3 OD3 H and allowed to stand for 16 hours at room temperature. It was not visibly altered and was easily dispersed in water. A similarly treated silica heated for one hour at 110�C. in a closed container became highly hydrophobic and could not be dispersed in water.
A precipitated calcium polysilicate (Hi-Sil 404) (1.0 part) was heated with 0.15 part of CH3 OD3 H in a closed bottle at 95�C. for 2 hours, at the end of which it was completely hydrophobic.
Although specific examples are mentioned and have been herein described, it is not intended to limit the invention solely thereto but to include all the variations and modifications falling within the spirit and scope of the appended claims.
|Cited Patent
|Filing date
|Publication date
|Mar 17, 1949
|Aug 18, 1953
|Ralph K Witt
|Method of producing a bonded structure
|Feb 14, 1951
|Jun 8, 1954
|Du Pont
|Method of esterifying the surface of a silica substrate having a reactive silanol surface
|Feb 1, 1954
|May 22, 1956
|Dow Corning
|Preparation of silane esters
|Sep 26, 1955
|Mar 11, 1958
|Gen Electric
|Recovery of methyl alkoxysilanes from methylpolysiloxanes
|May 21, 1956
|Jul 8, 1958
|Dow Corning
|Hydroxy-alkoxylated organosilicon compounds
|Jul 8, 1954
|Oct 21, 1958
|Gen Electric
|Organopolysiloxane compositions having pressure-sensitive adhesive properties
|Sep 14, 1959
|May 24, 1966
|Owens Corning Fiberglass Corp
|Process of coating glass fibers with hydrolyzed condensation product of amino silane and copolymerizable monomer
|Jul 19, 1965
|Jan 3, 1967
|Gen Electric
|Curable organopolysiloxane compositions
|Sep 3, 1965
|Mar 7, 1967
|Exxon Research Engineering Co
|Rubber reinforcing articles
|Dec 21, 1962
|Oct 31, 1967
|Exxon Research Engineering Co
|Bonded rubber-siliceous materials and process of producing same
|Jun 16, 1967
|Nov 17, 1970
|Rhone Poulenc Sa
|Organotrisiloxanes and their preparation
|Citing Patent
|Filing date
|Publication date
|Feb 28, 1977
|Jan 30, 1979
|Dresser Industries, Inc.
|Silane coated silicate minerals and method for preparing same
|Oct 23, 1978
|Nov 11, 1980
|Dresser Industries, Inc.
|Silane coated silicate minerals and method for preparing same
|Oct 20, 1978
|Apr 7, 1981
|Dresser Industries, Inc.
|Silane coated silicate minerals and method for preparing same
|Jun 18, 1980
|Jan 18, 1983
|Bayer Aktiengesellschaft
|Readily dispersible silicone-coated finely divided solids
|Dec 2, 1982
|Jun 12, 1984
|Dow Corning Corporation
|Surface treatment of inorganic fillers
|Nov 28, 1986
|May 24, 1988
|E. I. Dupont De Nemours And Company
|Structures surface modified with bidentate silanes
|Apr 23, 1991
|Feb 2, 1993
|U-Sus Distributors, Inc.
|Hydrophobic inorganic materials and process for making same
|Nov 19, 1992
|Apr 11, 1995
|Sri International
|Temperature-resistant and/or nonwetting coatings of cured, silicon-containing polymers
|Feb 24, 1997
|Jan 13, 1998
|Dow Corning Corporation
|Method for making hydrophobic silica gels under neutral conditions
|Feb 24, 1997
|May 12, 1998
|Dow Corning Corporation
|Hydrophobic organosilicate-modified silica gels
|Feb 24, 1997
|Aug 4, 1998
|Dow Corning Corporation
|Method for making hydrophobic organosilicate-modified silica gels under neutral conditions
|Feb 24, 1997
|Aug 4, 1998
|Dow Corning Corporation
|Method for preparing hydrophobic silica gels
|Feb 20, 1997
|Sep 15, 1998
|Dow Corning Corporation
|Neutral-aged hydrophobic organosilicate-modified silica gels
|Jun 20, 1997
|Feb 9, 1999
|Hewlett-Packard Company
|Asymmetric bidentate silanes
|Oct 31, 1994
|Jul 6, 1999
|Sri International
|Temperature-resistant and/or nonwetting coating of cured, silicon-containing polymers
|Jun 20, 1997
|Sep 7, 1999
|Hewlett-Packard Company
|Propylene-bridged bidentate silanes
|Feb 23, 1998
|Aug 22, 2000
|Dow Corning Corporation
|Neutral-aged hydrophobic silica gels with reduced surface area
|Jun 10, 1999
|May 29, 2001
|Dow Corning Corporation
|Method for preparing hydrophilic silica gels with high pore volume
|Mar 5, 2009
|Jan 24, 2012
|Sri International
|Method of imparting corrosion resistance to a substrate surface, and coated substrates prepared thereby
|Mar 5, 2009
|Sep 10, 2009
|Yigal Blum
|Method of Imparting Corrosion Resistance to a Substrate Surface, and Coated Substrates Prepared Thereby
|U.S. Classification
|428/394, 427/387, 428/405, 428/428, 428/446
|International Classification
|Cooperative Classification
|European Classification
|Jun 19, 1986
Owner name: STAUFFER-WACKER SILICONES CORPORATION
Free format text: CHANGE OF NAME;ASSIGNOR:SWS SILICONES CORPORATION;REEL/FRAME:004570/0295
Effective date: 19860204
|Aug 17, 1987
Owner name: WACKER SILICONES CORPORATION
Free format text: CHANGE OF NAME;ASSIGNOR:STAUFFER-WACKER SILICONES CORPORATION;REEL/FRAME:004761/0904
Effective date: 19870805


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5 Questions with Ed Sussman, married 50 years
Fountain Valley couple Freddie and Ed Sussman just celebrated their 50th wedding anniversary. We caught up with Ed Sussman to find out what makes their marriage work.
Q. How did you meet?
A. My wife is Fredda, but she goes by Freddie. We met on a blind date, and went to a movie in Hollywood to see "Frankenstein's Daughter." It wasn't love at first sight. I was attracted to her because we had a lot in common. I really hadn't been on a blind date before. We were married in North Hollywood on Jan. 19, 1963.
Q. What is the secret to your long marriage?
A. Our marriage works because we compromise. We don't go to bed angry, and we try to take life as it comes. What we love about each other is our children. They are all very successful, and we enjoy them. We have three children: Michael, age 49, lives in Mission Viejo with his wife, Lena; daughter Lisa, age 48, lives in Newport Beach. Our son Scott is 41 and lives in Rome, Italy, with his wife, Francesca. Last year, we took our entire family on a cruise to Hawaii. We also went to Italy to visit Scott and Francesca. And on our anniversary we celebrated with a family dinner.
Q. Are you retired?
A. I was superintendent of schools for the Downey Unified School District for 17 years and retired in June 2003 as a teacher and principal. I'm 71, and my wife is 69. On my 60th birthday, the Downey Unified School District named a school after me. South Middle School, where I was once a principal, was renamed Edward A. Sussman Middle School, and it was a proud moment for the entire family. Freddie is a retired preschool teacher. She worked at the United Methodist Preschool on Bushard and B'nai Tzedik Synagogue in Fountain Valley.
Q. After all these years, what do you two like to do together?
A. We enjoy movies, especially old movies like "Gone With the Wind" and "An Affair to Remember." We go to the movies about once a week, we go on errands together, and we enjoy a date night once a week. She is a caring, giving person and she says she likes my level of integrity. We both like to go to bed early and get up early.
Q. Any advice for newlyweds?
A. Never stay angry at each other, and always listen. A great line that has stayed with me is when a man was asked what is the best gift he can give to his children, he answered, "to love their mother." And that's a powerful message.
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Kill Busey: Vol. 1 & 2
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Playdead's followup to Limbo expands on and improves all of that game's ideas so thoroughly, there's no question why it took six years to get here.
Homefront may look pretty, but it's a monotonous and confused slog.
It's hard to imagine a better Doom game in 2016 than this exhilarating, darkly witty new take on id's classic.
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A light, high-speed reconnaissance ground vehicle in the Covenant arsenal, the Ghost hover-bike can pack quite a punch in the hands of a skilled pilot.
The Warthog jeep is one of the most commonly deployed ground vehicles in the arsenal of the UNSC. It can be adapted for a number of roles, from troop transport, to anti-armour, to reconnaissance scout.
The M12A1 Light Anti-Armor Vehicle or 'Rocket Warthog' is a special variant of the Halo series' signature vehicle. It features a mounted gun which fires rockets and only appears in the PC and Mac versions of Halo: Combat Evolved.
Alternatively called the "Spanker" or "Jackhammer", the M41 is a heavy ordinance weapon of the UNSC arsenal. It sports a 2x scope, and can fire over long distances with devastating accuracy.
The M9 High-Explosive Dual-Purpose Grenade, also known as the Fragmentation Grenade or 'Nade' to most players, Is the main grenade for the UNSC.
The MA5C is a fully automatic, air-cooled, gas-operated, short-to-mid range weapon. The weapon's power is described as falling somewhere between the MA5B Assault Rife, and the BR55 Battle Rifle.
Razor sharp crystalline projectiles are fired from this elaborately designed Covenant weapon, and it is widely believed that they use heat and organic signatures to home in on targets. The needles cause a chemical reaction in close proximity resulting in an explosive effect.
The Covenant Type-1 Antipersonnel Grenade, also known as the Plasma Grenade, Sticky Grenade, Holy flare, Holy light, or the Demon flare by the Covenant is similar to the UNSC Fragmentation Grenade in that it is a hand-thrown Anti-Infantry and Anti-Vehicle weapon.
The Plasma Pistol, like the Plasma Rifle, fires directed energy bolts instead of traditional projectile ammunition. It is capable of quickly firing low powered shots, or of charging a single high-powered blast which can rapidly deplete energy shielding.
The Plasma Rifle uses plasma technology firing directed energy bolts instead of projectile ammunition.
Humanity's tank, it can carry four/five passengers in campaign. in Multiplayer in can hold Four/One. In Halo 3 the turret was replaced by a passenger.
The topmost bone in the human body, it contains the brain and the eyes, and is generally considered a good thing to keep intact.
The SRS99D Sniper Rifle is the primary long-range rifle used by UNSC forces. The only drawbacks are its cumbersome reload, and scarce ammunition.
Whoever built, discovered or reverse-engineered them, teleporters get you where you want to go immediately. Hopefully without materializing you halfway into a wall.
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Book your room at La Quinta Inn & Suites NE Long Beach / Cypress
Get an overview of this hotelHotel in Hawaiian Gardens with free breakfast and fitness center
Situated in Hawaiian Gardens, this hotel is 0.8 mi (1.2 km) from Hawaiian Gardens Casino and within 3 mi (5 km) of Cypress College and La Palma Intercommunity Hospital. El Dorado Regional Park and Los Alamitos Joint Forces Training Base are also within 3 mi (5 km).
Hotel Features
A fitness center, a spa tub, and a business center are available at this smoke-free hotel. Free continental breakfast, free WiFi in public areas, and free self parking are also provided. Additionally, a meeting room and a 24-hour front desk are onsite.
Room Amenities
All 53 rooms provide conveniences like refrigerators and microwaves, plus free WiFi and flat-screen TVs with cable channels. Premium bedding, coffee makers, and free local calls are among the other amenities available to guests.Would you like to give us feedback? Share it! Opens in a new window
La Quinta Inn & Suites NE Long Beach / Cypress12441 Carson St Hawaiian Gardens CA 90716
Hotel Amenities
Hotel Amenities
La Quinta Inn & Suites NE Long Beach / Cypress features a spa tub and a fitness center. Public areas are equipped with complimentary high-speed wireless Internet access. Business-related amenities consist of a business center and a meeting room. Guests can enjoy a complimentary breakfast. Complimentary self parking is available on site.
La Quinta Inn & Suites NE Long Beach / Cypress is a smoke-free property.
- 24-hour front desk
- Business center
- Fitness facilities
- Free breakfast
- Free self parking
- Free WiFi
- Number of floors - 4
- One meeting room
- Smoke-free property
- Spa tub
- Total number of rooms - 53
Family Friendly Amenities
- Cribs/infant beds (complimentary)
- Free Wi-Fi
- Microwave
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Air conditioning
- Cable TV service
- Coffee/tea maker
- Free toiletries
- Free cribs/infant beds
- Daily housekeeping
- Desk
- Flat-panel TV
- Free local calls
- Free WiFi
- Hair dryer
- Iron/ironing board
- Microwave
- Premium bedding
- Premium TV channels
- Private bathroom
- Refrigerator
- Shower/tub combination
Where to Eat
Guests are offered a complimentary continental breakfast.
Nearby Things to Do
Recreational amenities at the hotel include a spa tub and a fitness center.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
Hotel Policies
Check-in time starts at 3 PM
Check-out time is Noon
Payment types
- Pets stay free
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Pets allowed (no fees)
No rollaway/extra beds available
Hotel Name
- Quinta Hawaiian Gardens
- Quinta Inn Hawaiian Gardens
- Quinta Inn NE Long Beach Cypress Hawaiian Gardens
- La Quinta Inn & Suites Hawaiian Gardens Hotel Hawaiian Gardens
- La Quinta Inn And Suites Hawaiian Gardens
- Quinta Inn NE Long Beach Cypress
- Quinta NE Long Beach Cypress Hawaiian Gardens
- Quinta NE Long Beach Cypress
We should mention
Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


text:
Denis Kang returns to the cage April 16 in Seoul, South Korea. |
Dave Mandel/Sherdog.com
Kang, 33, signed a non-exclusive, multi-fight deal with the South
Korean promotion in February. The Canadian-based French Korean was
released by the
UFC in December 2009 following a 1-2 run which included
stoppage losses to Michael
Bisping and Alan
Belcher, and a decision win over Xavier
Foupa-Pokam. Kang competed twice in 2010, submitting Dae Won Kim
at a W-1
MMA event in June before fighting Paulo Filho
to a controversial split draw at
Impact FC 2 in July.
Before his engagement with Lee, Kang is expected to meet Jesse
Taylor in the main event of
Battlefield Fight League 7 in Nanaimo, B.C., Canada, on March
Like Kang, Lee also competed under the Pride banner and once held
the heavyweight title of now-defunct Korean promotion
Spirit MC. The 29-year-old
Team Posse representative has not fought since 2008, when he
recorded a pair of wins under the Deep and
Challenge banners. Lee's professional ledger stands at 14-2,
his only losses coming to Pride heavyweight Yoshihiro
Nakao and current M-1 middleweight contender Magomed
Also slated to appear at Road FC 2 is Lee's lightweight teammate
Woo Sung
Yu, who faces
Wajutsu Keishukai fighter Koji Ando, and
Team Force featherweight prospect Young Bok
Gil, who meets Sengoku
veteran Shoko Sato.
A bout between bantamweight contenders Michael McDonald and John Lineker headlines UFC Fight Night 91. Check out the video preview of the main event showdown. read news >>


text:
THE former world record holder and Olympic track star will head to Scotland next May to take part in the Great Run British Marathon Series.
THE former world record holder and Olympic track star will head to Scotland next May to take part in the Great Run British Marathon Series.
THE unnamed pair would become the world's first transgender Olympians if they are selected to compete.
HER dad made her an indoor track from a combine harvester when she was paralysed and now Sammi aims to reap the rewards for him at her first Olympics.
THE Kenyan narrowly missed out on a world record time but did smash the London Marathon course
Glasgow is set to take centre stage in 2019 and will play host to 600 competing athletes from 50 different countries at Glasgow's Emirates Area.
INSPIRATIONAL Maria has thrived in athletics despite living with diplegic cerebral palsy, and the Dunbar Grammar School student hopes for medal success in Rio.
FARAH, who suffered a rare defeat in Edinburgh recently, sent the crowd into raptures at the Emirates Arena with a blistering finish to claim his first victory of the year.
EUROPEAN ATHLETICS' board meet to discuss host of the competition and these British athletes are in no doubt that Glasgow would be a great location.
EUROPEAN 200m champion can't wait to race in front of a Scottish crowd as he get set for a 60m showdown with fellow Brits Richard Kilty and CJ Ujah.
NOW 20, and coming off a stunning summer that saw her smash one record after another, Asher-Smith has made running look like child's play.
SPORTSWEAR giant says that doping revelations which came to light in report earlier this month constitute a breach of its agreement with the IAAF.
THE board of Scottish Athletics is determined to take a tough stance against doping as drug allegations rock the sport around the world.
MICHAEL reckons the corruption in the IAAF is huge and that something needs done about it.
THE event would be held at the Emirates Arena in Glasgow and comes following huge success of the 2014 Commonwealth Games.
THE Olympic gold medalist has been in fine form since returning from the birth of her son Reggie, as she won World Championship Heptathlon gold in Beijing.
Scottish Daily Record


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Home > Press > Arrowhead to Present at Oppenheimer 21st Annual Healthcare Conference
Arrowhead Research Corporation (ARWR 1.02, 0.00, 0.00%) today announced that Dr. Christopher Anzalone, Chief Executive Officer, will be presenting at the Oppenheimer 21st Annual Healthcare Conference at 10:50 a.m. ET on Tuesday, November 2, 2010, at the Waldorf-Astoria Hotel in New York City, NY. Dr. Anzalone plans to provide a corporate summary and update on the Company's progress.
Dr. Anzalone will also host one-on-one meetings with members of the professional community in New York on November 3-4, 2010. Professional investors can schedule a meeting with Dr. Anzalone by contacting Brandi Floberg at 212-481-2050 or Those investors attending the conference are encouraged to sign up to meet with Dr. Anzalone at the conference through their Oppenheimer sales representative.
Over more than 20 years, the Oppenheimer Healthcare Conference has become a highly valuable investor conference in this sector. The conference will include a core group of public and private companies who are leaders and pioneers in the pharmaceutical, biotechnology, medical device, healthcare facility, health technology and distribution, provider and service industries.
About Arrowhead Research Corporation
Arrowhead Research Corporation (ARWR 1.02, 0.00, 0.00%) is a nanotechnology company commercializing new technologies in the areas of life sciences and electronics. Arrowhead is seeking to build value for shareholders through the progress of its subsidiaries and investments. Currently, Arrowhead is focused primarily on its two majority owned subsidiaries: Unidym, a leader in carbon nanotube technology for electronic applications, and Calando, at the forefront of clinical application of RNAi delivery technology. Arrowhead also has minority investments in two privately held nanobiotech companies.
For more information, please click here
The Piacente Group
Brandi Floberg, 212-481-2050
Copyright © Arrowhead Research CorporationIf you have a comment, please Contact us.
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text:
Definition of Calamity Jane in English:
Calamity Jane
(Circa 1852–1903), American frontierswoman, noted for her skill at shooting and riding; born Martha Jane Cannary.
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text:
WEST CAPE MAY _ Voters here on Tuesday rejected ballot questions to increase the size of the governing body and to reduce the pay elected officials make.
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text:
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Bioinformatics Technologies
your country
Solving modern biological problems requires advanced computational methods. Bioinformatics evolved from the active interaction of two fast-developing disciplines, biology and information technology. The central issue of this emerging field is the transformation of often distributed and unstructured biological data into meaningful information.
This book describes the application of well-established concepts and techniques from areas like data mining, machine learning, database technologies, and visualization techniques to problems like protein data analysis, genome analysis and sequence databases. Chen has collected contributions from leading researchers in each area. The chapters can be read independently, as each offers a complete overview of its specific area, or, combined, this monograph is a comprehensive treatment that will appeal to students, researchers, and R&D professionals in industry who need a state-of-the-art introduction into this challenging and exciting young field.less
409 pages; ISBN 9783540268888
Read online, or download in secure PDF format
Title: Bioinformatics Technologies
Author: Yi-Ping Phoebe Chen
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5G Mobile and Wireless Communications Technology 2016 US$ 82.00 440 pages
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text:
All Press Releases
Ecuador Indigenous Leaders Issue Plea for Americans to Help In Battle Against Chevron's Toxic Dumping
In Open Letter, Ecuadorians Ask Americans To Demand That Chevron Clean Contamination Dumped in Rainforest
23 May 2011 | Amazon Defense Coalition
New York, NY – The indigenous and farmer communities of Ecuador have released an open letter to the American people calling on them to help in the historic battle to force Chevron to clean up the toxic mess the oil giant left their country's Amazon rainforest, considered by many to be the worst oil-related disaster on earth. More »
Report Finds Chevron Downplaying Shareholder Risk and Liability from $18 Billion Ecuador Judgment
11 May 2011 | Amazon Watch, RAN
San Francisco, CA – Two weeks before Chevron's Annual General Shareholders meeting, a report released today finds that Chevron's multi-billion liability in Ecuador poses serious financial and operational risk to the company and its shareholders. More »
To Avoid a Jury Trial, Chevron Now Wants to Remove Donziger and Lawyer John Keker from RICO Case
Oil Giant Clearly Scared of Jury Trial That Could Create Additional Liability, Plaintiffs Say
21 April 2011 | Amazon Defense Coalition
New York, NY – To avoid a jury trial, Chevron has filed papers seeking to remove Steven Donziger and John Keker out of the first phase of a racketeering case in New York that the oil giant filed in February to try to escape paying an $18 billion judgment. More »
Miami Herald Catches Chevron in Lie about Ecuador Well Site
Reporter finds oil sludge in "remediated" pit that's part of Chevron's fraud, plaintiffs say
19 April 2011 | Amazon Defense Coalition
Washington, DC – In a story published in today's newspaper, journalist Jim Wyss said he witnessed "thick oil slicks" only a few feet into the ground of a dirt-covered storage pit Chevron told him the day before had been remediated of all oil. More »
Chevron Selling Assets to Escape Enforcement of $9.5 Billion Judgment in Ecuador, Plaintiffs Charge
Court Filing Requests that U.S. Judge Increase $21.8 Million Bond
5 April 2011 | Amazon Defense Coalition
New York, NY – Chevron is divesting itself of overseas assets that could be used to enforce the $9.5 billion legal judgment against the oil giant for massive contamination of the Ecuadorian rainforest, lawyers for the Ecuadorian plaintiffs stated in a legal brief submitted to the Southern District of New York last week. More »
U.S. Judge's Decision a "Slap in the Face" to Ecuadorians Fighting to Hold Chevron Accountable For Eco-Disaster in Amazon Rainforest
7 March 2011 | Amazon Defense Coalition
New York, NY – Statement by Karen Hinton, spokesperson for the Ecuadorians who recently won a $9.5 billion judgment against Chevron for oil contamination, about today's Southern District Court of New York decision on the preliminary injunction. More »
Court Affidavit Exposes 18 Years of Chevron's Unethical Conduct in $9.5 Billion Ecuador Lawsuit
Oil Giant Attempted to "Buy or Bully" Its Way Out of Environmental Liability for Creating "Amazon Chernobyl"
7 March 2011 | Amazon Defense Coalition
New York, NY – A new 42-page sworn affidavit, backed by hundreds of pages of exhibits, has outlined in stunning detail Chevron's 18-year effort to undermine the Ecuador court that recently awarded a $9.5 billion judgment against the company for dumping billions of gallons of toxic waste into the rainforest of the South American nation and creating what locals call the "Amazon Chernobyl". More »
Damning Video of Former Chevron Employee Sheds Light on Case for Justice in Ecuador
Video Reveals the Blatant Recklessness that Led to Widespread Contamination and Illness in the Region
2 March 2011 | Amazon Defense Coalition
Washingon, DC – In a video released today, a former oil operations assistant for Texaco (now Chevron) lays bare the stunning negligence and deliberate dumping of 18.5 billion gallons of highly toxic waste into Ecuadorian ecosystems by Chevron in its pursuit of oil in the Amazon rainforest. More »
Federal Court Hears Arguments to Compel Chevron "Dirty Tricks" Operative Diego Borja to Testify Immediately on Charges He Assisted Oil Giant In Corrupting Environmental Lawsuit
16 February 2011 | Amazon Defense Coalition
San Francisco, CA – Today the Northern District Court of California will hear a motion by Ecuadorian plaintiffs to compel Chevron operative Diego Borja and his wife, Sara Portilla, to be deposed on charges Chevron, with their assistance, tried to corrupt a massive oil contaminatin lawsuit in Ecuador. More »
Chevron Found Guilty in Landmark Trial; Plaintiffs Respond
Oil Giant Ordered to Pay Record $9 Billion to Ecuadorian Rainforest Communities
15 February 2011 | Amazon Watch
Quito, Ecuador – Plaintiffs gathered in Quito after oil giant Chevron was found guilty yesterday of massive environmental contamination in the Ecuadorian Amazon and was ordered to pay $9 billion in fines in one of the largest environmental damages awards on record. The ruling comes after more than 17 years of litigation brought by thousands of indigenous peoples and farmers still living amidst deadly contamination in the northeastern Amazon region of Ecuador. More »


text:
When the zombie apocalypse arrives, will you know how to find the nearest gun shop?
Denver blog posts run for their lives.
The Huffington Post gets in on some hot action when a Diamond Cabaret truck pulls up behind CBS4 reporter Greg Moody during a live feed from a Rockies game.
Meanwhile, Denver Frank has localized something called Map of the Dead, which will help you survive the inevitable zombie apocalypse "by keying you in on where gun shops, outdoor stores, hospitals, pharmacies and grocery stores are."
Predominantly Orange: "Demaryius Thomas Not Sad To See Tebow Go."
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IBS Symptons May Never End According to New Survey
IBS Patients Battle Condition Into Old Age
While the survey of both GPs and patients supported by Cheshire-based Peckforton Pharmaceuticals suggests no significant impact from the recession, it seems to indicate that many IBS victims suffer the condition for their entire lives.
While the average age range of IBS patients seen by the GPs is between 26-35 years, the average age of the patients surveyed, all of whom were members of The Gut Trust, the National Charity for IBS, was 60 years.
And of those patients who took part in the survey 35 per cent reported experiencing IBS symptoms/flare ups nearly every day while 21 per cent experience symptoms three to four times a week.
Dr Michael Taylor, national spokesman for the Family Doctor Association said: "The significant finding from this survey seems to be that symptoms just don't go away. Most people who come to GPs presenting IBS symptoms tend to be younger than those patients polled in this survey.
"As people get older, they tend to cope, or so we thought. But the findings of this survey suggest they continue to have symptoms and flare ups into their later years. The cut off for new cases of IBS seems to be the age of 40. We see far fewer people presenting IBS symptoms after this age but older people continue to suffer.
"This survey poses the question, does IBS ever go away?" added Dr Taylor. "The members of the Gut Trust were much older than what had been considered the usual age range for IBS, but their contribution offered a valuable insight into how common IBS is in the middle aged and elderly'.
Michael Mahoney, one of Britain's leading clinical hypnotherapists to specialise in the condition and author of the IBS Audio 100 self-help programme, said he hoped the findings of the survey would spur doctors and specialist therapists to look at new ways of alleviating the suffering currently being endured by older IBS patients.
"We have known, for some time now that there is no simple cure for IBS but this new information of the level of suffering among older patients is still shocking," said Mr. Mahoney from his Warrington consulting rooms.
"We must continue to do what we can to help alleviate the often debilitating symptoms suffered by patients whether it be through medications, hypnotherapy or both. To simply recognise it, and do nothing is not acceptable."
Jan Taylor, a spokesperson for Peckforton Pharmaceuticals and who was involved in commissioning the survey said: "We were in a fortunate position because of our relationship with Mike Mahoney, The Family Doctor Association and The Gut Trust, so it enabled us all to work together to examine the current picture of IBS amongst the sufferers and the Healthcare professionals who help them to manage their condition".
"Much of the survey confirmed our suspicions, but I found it quite shocking to learn that the debilitating and painful symptoms of IBS, continues to blight people's lives into their golden years, and healthcare professionals are still searching for solutions to manage a complex condition" said Jan speaking from her Crewe, Cheshire office.
"Most of the respondents did not feel that their current treatment was able to provide all the answers, and IBS was a condition that requires management and varied solutions from alternative therapy and professional intervention, to over the counter medication"
For further information contact Jan Taylor on 07786 855932
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These authors contributed equally for the study.
Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion
Version of Record online: 8 AUG 2006
DOI: 10.1111/j.1365-2893.2006.00799.x
Journal of Viral Hepatitis
Volume 14, Issue 4, pages 269–275, April 2007
Additional Information
How to Cite
Yuen, M.-F., Wong, D.K.-.., Zheng, B.-J., Chan, C.C.-.S., Yuen, J.C.-.H., Wong, B.C.-.Y. and Lai, C.-L. (2007), Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion. Journal of Viral Hepatitis, 14: 269–275. doi: 10.1111/j.1365-2893.2006.00799.x
Publication History
- Issue online: 8 AUG 2006
- Version of Record online: 8 AUG 2006
- Received March 2006; accepted for publication May 2006
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