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Red Sox transferred 3B Pablo Sandoval from the 15-day disabled list to the 60-day disabled list.
Pablo Sandoval underwent season-ending surgery Tuesday to repair a torn labrum in his left shoulder.
Red Sox manager John Farrell said on MLB Network Radio on Sirius XM that Pablo Sandoval's left shoulder surgery was scheduled for Tuesday morning.
Pablo Sandoval needs reconstructive surgery on his left shoulder, per ESPN's Buster Olney.
Peter Abraham of the Boston Globe hears from a source that Pablo Sandoval faces "significant" surgery on his left shoulder.
Pablo Sandoval will require surgery on his ailing left shoulder.
Pablo Sandoval indicated that the inflammation in his balky left shoulder has subsided.
According to WEEI's Rob Bradford, the Red Sox have been encouraged by Pablo Sandoval's "approach and results" toward dropping weight over the last two weeks.
Pablo Sandoval (shoulder) will have another visit with Dr. James Andrews in two weeks.
Red Sox president Dave Dombrowski said Friday that there's "a lot going on" with Pablo Sandoval's left shoulder and he could require surgery.
FOX Sports' Ken Rosenthal reports that Pablo Sandoval (shoulder) will receive a second opinion from Dr. James Andrews.
Pablo Sandoval's former trainer Ethan Banning said Sandoval needs a "baby sitter" to help him watch his weight.
Pablo Sandoval (shoulder) will undergo an MRI on Thursday.
According to Yahoo's Jeff Passan, Pablo Sandoval "wants to stay in Boston only if he can play every day."


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Journey to the Cons, Vol. 3
About 1 Month, 20 Hours, 42 Minutes ago.
Once again the time has come for the Overmare Studios to take over on the world. In just over a week, we will be travelling to Baltimare, attending BronyCon 2016 in not one, not two, but three different ways!


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Your search returned 379 results
AfricanHome Guest HouseWestern Cape » Cape Town » Sea Point
Our African Home guest house was built by Lord Nelson in 1790 as a hunting lodge using granite from Table Mountain, which makes it one of the oldest buildings in the Sea Point suburb. Now a national monument, it still bears several features from that time, such as the bubbling horse trough on the entrance terrace.
The property is split into several levels, giving rise to different areas containing small, closed-off courtyards so that every guest can find their own private place.
A large…Read more
Africansun Guest SuitesWestern Cape » Cape Town » Milnerton
"African Sun Guest Suites .......refined lodging with home from home comforts....... "Our tastefully self catering apartments , located in the central and secure Cape Town suburb of Milnerton, is just a five minute walk to the beach and a short drive to a host of tourist attractions.Tableview and Bloubergstrand's famous bathing and water-sports beaches are within a ten minutes drive, while the Milnerton Golf Course is within walking distance.Further along the Atlantic Beach Golf Course…Read more
Afro-Chic Guest HouseWestern Cape » Cape Town » Table View
BUDGET ROOM Our budget room has a double bed and is equipped with a mini-fridge, coffee and tea making facilities, a fan and a heater. This room has a most luxurious en-suite bathroom with a spa-bath and a double seater shower with a water cascade and double basin. COSY ROOMS The rooms are equipped with a mini- fridge, coffee and tea making facilities, a fan and a heater. All have en-suite bathrooms with shower, toilet and basin. DELUXE ROOMS This lovely honeymoon suite has 2 single…Read more
Alba Guest FarmWestern Cape » Cape Town » Durbanville
Alba Guest Farm is an easy 30 minutes' drive from the City of Cape Town, Table Mountain, and its famous V&A Water Front, your departure point to Robben Island where former President Nelson Mandela was jailed for 27 years. Stellenbosch, Somerset West, Strand,Paarl, Franschhoek, the Southern Suburbs, Cape Town International Airport, Constantia, Clifton, Camps Bay, Cape Point and Muizenberg are all within a leisurely 20 - 45 minute drive through the beautiful vineyards of the Cape…Read more
Allegria GuesthouseWestern Cape » Stellenbosch
The villa lies on a 2 hectare country estate, entirely surrounded by vineyards. A portion of our grounds, which consist of excellent soils, is planted with organically cultivated Shiraz grapes.
The views all around are breathtaking; rolling vineyards and mountain chains as far as the eye can see.
To put it briefly, these are restful and inspiring surroundings, which form the best possible base to explore…Read more
Amakhaya LodgeWestern Cape » Cape Town » Hout Bay
The Lodge:The Amakhaya Golf Lodge is situated idyllically sited fairly close to the white sand beaches Hout Bay & Llandudno and has spectacular and awesome views of the Chapman's peak, the mountains, the bay and the Atlantic Ocean beyond. We offer you the perfect starting point for Sight Seeing, Golf & relaxation. The Central City of Cape Town is reachable in 20 minutes driving time along the stunning coast road below the 12 Apostel. 20 golf courses are reachable from 20 to 60 minutes…Read more
Andros Boutique HotelWestern Cape » Cape Town » Claremont
The Andros Boutique Hotel is a gracious Cape Dutch homestead, built in 1908 and designed by Sir Herbert Baker. Restored and updated, carefully preserving its old-world charm, the house is set in large, mature park-like gardens in die heart of Claremont, one of Cape Town's beautiful Southern suburbs. The Manor house is furnished in an elegant and traditional style, complementing the original features in this beautiful graceful home.Set in the garden are eight spacious bedrooms, each with…Read more
Antrim Villa
This quaint hide-away is situated between Green Point and Sea Point and is only minutes away from the famous V & A waterfront, the City Centre, Camps Bay and Table Mountain and a 10 minute walk to the new Green Point Stadium. It is also only a few paces on foot to the beautiful Sea Point Promenade or the Mouille Point Lighthouse for an early morning jog or sundowner stroll.Antrim Villa is completely new, having . opened it's doors in December 2008. The interior is a mixture of African…Read more
Aqua VistaWestern Cape » Cape Town » Somerset West
Set on the slopes of the Helderberg Mountain in Somerset West with beautiful views of False Bay to Cape Point, Aqua Vista Guest House offers its visitors a chance to relax in simplistically styled luxury. The main house is surrounded by huge tranquil gardens, teeming with bird-life, and a freshwater swimming pool offers welcomed respite from the hot African sun.
Relaxing with refreshment in one of the pool lounges whilst taking in the unparalleled views is a must for all who stay at…Read more
Aquamarine Guest HouseWestern Cape » Mossel Bay
Luxury 4 star accommodation in the Garden Route - Aquamarine Guest House is a 5 bedroom gem, with a fresh, modern touch. It is centrally located in the main street of Mossel Bay, with secure off-street parking and remote controlled gate. Within easy walking distance ( 5 minutes ) from Santos Blue Flag beach, shops, restaurants and hospital. Each spacious room has a luxurious en-suite bathroom, with double basins and both a bath and shower, as well as a patio with ocean view and pool /…Read more
Aquila Private Game ReserveWestern Cape » Touws River
Aquila Private Game Reserve is basically wedged between the Langeberg and the Outeniqua Mountains, in the Klein Karoo. Setting the scene are spellbinding landscapes, carpets of wild flowers and wildlife.
Accommodation options at Aquila Private Game Reserve are premier, family or luxury chalets.
Aquila has two large swimming pools, each with a pool bar, overlooking the reserve. There is a large African-style dining area, and two smaller dining areas - all with blazing log fires and smoky…Read more
Arniston HotelWestern Cape » Arniston
Arniston is a leisurely two-hour drive from Cape Town, on a road that meanders through the beautiful rolling hills of the Overberg region.The Arniston Spa Hotel is set in one of the Cape's most exquisite locations, next to an old fishing village, surrounded by pristine beaches and nature reserves. The luxurious 4-star Arniston Spa Hotel is internationally known as one of the world's great getaways. Touched by the spray from the Indian Ocean, we welcome you with panoramic views of the…Read more
Ashanti Green PointWestern Cape » Cape Town » Green Point
Newly renovated and super stylish, Ashanti Green Point offers an elegant alternative for travellers looking for quieter, more private accommodation in Cape Town. Green Point is celebrated for its vibrant nightlife, and borders the colourful suburb of Sea Point, with its myriad shops, cafes and restaurants, as well as its beautiful promenade – a golden mile of seafront walkway and secluded beaches. Also within walking distance are the V&A Waterfront and iconic Cape Town Stadium, yet a…Read more
Ashanti Lodge & Travel CentreWestern Cape » Cape Town » Gardens
The accommodation options at Ashanti Lodge Gardens feature everything from camping and dormitory style rooms to doubles/twins and singles with shared facilities as well as stylish rooms with private bathrooms. A twin room will have two single beds whereas a double room has just one double bed. The majority of the en-suite rooms (with private bathrooms) are in our Guest Houses around the corner in Union Street. We have great double en-suite rooms that are fully serviced daily with fresh…Read more
Ashby Manor AccommodationWestern Cape » Cape Town » Fresnaye
Our accommodation outfit owns a large beautiful Victorian self-catering guesthouse named Ashby Manor situated in an exclusive area below Lion's Head in Fresnaye, Sea Point. There are ten bedrooms ranging from single to four bedded mostly en-suite and some with balconies and magnificent sea views.
A communal, fully equipped kitchen leads to a large sunny dining room and there are communal lounges with TV/DStv. Every convenience is offered and there is daily service provided by helpful…Read more


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QTStaffing provides highly qualified dialysis nurses and other professionals on a temporary and permanent basis to our healthcare facility clients. QTStaffing offers dialysis and other healthcare professionals flexible and creative career opportunities.
With a small business attitude where every contact counts, we are committed to providing our clients – more... and healthcare professionals with the highest level of service. – less–ZoomInfo


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1 review | 1 out of 5
This review is not about the classic movies included in the collection. I have seen all the movies several times and overall, I like and appreciate the collection. The problem was the picture quality was so poor they were almost not watchable. Until someone does a much better job on restoring and transfering these classic films, I recommend...forget about it!


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Lake Viljandi is in a primeval valley, which is 11 m deep, 450 m wide and 4600 metres long. The lake is well-known in Estonia thanks to the song about the boatman of VIljandi, who day-dreams about the beautiful blue eyes of a girl he once saw when he was young. The trail that goes around the lake will take hikers to the observation platform on the other shore where you will see a charming and unique silhouette of the town.
The lake is really big, you can spend hours walking round it. The park in its surrounding is great, thick and beautiful. Really reccommend it.
Nice lake where you can walk by and do your daily exercise. There is a nice playground for the children
If you are looking little time off when visiting Viljandi with Kids then it is the place you have to go. It has a great playground for Kids and for adults you can do workout if you're not feeling to...


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One more of these and that'll see my entire 2015 reading documented. After I've posted that, I'll do a summary "year in reading" post, you know, with pie charts and shit. 1,815 more words
Tags » Kari Sperring
The Grass King's Concubine, Kari Sperring
(review by Aliette de Bodard)
This is a book with several narrative strands: one in the present, where Aude, born to wealth, runs away and seeks to understand where her family's fortune came from; and one in the past, where a man called Marcellan enters the Rice Palace, domain of the Grass King, the mythical being who embodies the earth and the harvest. 263 more words


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- Brass Taps by Nicholas F. Mondello
- Under the Spell of Spain by Nicholas F. Mondello
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3 Firefighters Injured, Dog Dies In Temple Hills FireThree firefighters were injured following a fire in Temple Hills on Sunday afternoon, according to Mark Brady, Chief Spokesperson with the Prince George's CountyFire/EMS Department.
No Charges In Shooting Death Of Md. Cop By Another OfficerThe shooting death of a Prince George's County police officer by another officer launched a criminal probe.
Trailer Hauling Orange Juice Bursts Into Flames in BowiePrince George's County firefighters doused a tractor trailer hauling orange juice that went up in flames early Tuesday morning, authorities said.
Police: Prince George's County Man, 33, Killed in JFX Motorcycle WreckA Prince George's County man died after crashing his motorcycle on Jones Falls Expressway early Monday morning, authorities said.
Man Arrested In Connection With Triple Homicide in ForestvillePrince George's County Police have arrested a man they say gunned down three people and injured two others in Forestville.
Suspect Sought in Prince George's County Triple MurderPrince George's County Police are looking for a suspect caught on camera fleeing the scene of a triple homicide in Forestville Friday night.
Police Identify 3 People Fatally Shot In Washington Suburb Police have identified two women and one man who were fatally shot at a home in a Washington suburb.
Man's Body Found On Prince George's County RoadA man's body was found on the side of the road in Prince George's County on Wednesday morning.
School System To Roll Out Changes In Wake Of Child Porn CaseAfter a huge child pornography scandal in Prince George's County, officials have announced they will make big changes.
Md. Teacher Charged With Illegal Sexual Contact With StudentPrince George's County police say a 45-year-old high school teacher has been charged with having illegal sexual contact with a student.
Man Accused of Ramming Cruisers Not Criminally ResponsibleA man accused of ramming two police cruisers with a dump truck has been found not criminally responsible.
Mall Shooting Suspect Had Turned In 7 Weapons VoluntarilyA federal security officer charged with killing three people in Maryland, including his estranged wife, voluntarily surrendered seven guns after a March court order, authorities said Tuesday.


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Topic: 3-D Printing
This Week's Must-Haves: a Solar Charger Inspired by Nature
Plus, a 'do not disturb' button that makes getting work done a breeze
By Emma Bazilian on Nov. 17, 2015 - 7:12 PM EST
This week, Adweek is highlighting solar-powered smartphone charger that looks a lot like a Japanese Ginkgo tree, a workspace organizer that makes your supplies and devices appear to be underwater,…
10 Digital Innovators Who Are Defining Creativity in a Tech-Fueled World
Inventing the future of science, software and storytelling
By David Griner on Jul. 19, 2015 - 8:29 PM EDT
The only thing more impressive than the seemingly limitless world we live in now is what's just around the corner. Innovation is exploding across every industry, and ideas that once…
Dita Von Teese Models an Incredible 3-D Printed Gown
Design based on the Fibonacci sequence
By David Kiefaber on Mar. 13, 2013 - 11:25 AM EDT
It shouldn't really count as news when Dita Von Teese models something, but she recently showed off a 3-D printed nylon gown based on the Fibonacci sequence, which is cool…


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A periodically poled lithium niobate (PPLN) optical parametric oscillator using a simple grazing-incidence grating cavity configuration (GIOPO) for broad and fast wavelength tuning has been developed for the mid-infrared region. The GIOPO is capable of producing ∼100 mW of infrared power with a bandwidth of 0.2 cm-1 at 3000 nm. Since pressure-broadened linewidths are in the range of a few tenths of a wavenumber, the GIOPO output bandwidth is suitable for exciting single well-separated rotational lines of many gases under typical atmospheric conditions. We have used the highly sensitive technique of photoacoustic detection coupled with this compact all solid-state GIOPO developed in our laboratory to achieve ppb level detection and analysis of gaseous molecules. Result shows a photoacoustic spectrum taken with 1 ppmV of C2H4 in comparison with a FTIR spectrum. The PA spectrum has a resolution of 0.2 cm-1, clearly distinguishing the rotational structure of the molecule. A plot of the PA signal as a function of C2H4 gas concentration is also obtained. A linear relationship between the C2H4 concentration and the PA signal is established over at least two decades of gas concentration. A minimum sensitivity of 10 parts in 109 by volume (10 ppbV) C2H4 in nitrogen was obtained in the direct measurement. The current limit on the detection sensitivity is determined by the background, noise and the accuracy is mainly determined by calibration errors involved in the gas mixing procedure. In order to improve on the sensitivity, a multipass cell arrangement is being designed.
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25% off lightweight hoodies? Heavy. Use HOODSRGOOD.
Original oil painting by American artist Michael Creese.
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Work on designing and implementing a patient-centric, personal health record cloud platform based on open-source Indivo X system. We adopt cipher text-policy attribute-based encryption to provide privacy protection and fine-grained access control.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


text: 2. FLIR Systems designs and manufactures thermal imaging systems and operates through divisions like thermography and commercial vision systems. Revenue for the third quarter rose 16% to $333 million. Operating margins dipped, while net income was up 5% to $63 million. Although FLIR derives about one-third of its revenue from the U.S., it is trying to diversify its revenue sources by gaining traction in other geographies. The company built an operation center in Riyadh during the third quarter, eyeing to capture a part of the proposed $60 billion arms deal announced between the U.S. and Saudi Arabia. Based on third-quarter results, the outlook for revenue and earnings per share for 2010 has improved. Revenue and net earnings per share for 2010 are pegged at $1.375 billion to $1.4 billion and $1.53 to $1.56, respectively. Order backlog stands at $533 million, with delivery scheduled within the next 12 months. The stock is trading at 10 to 11 times its 2011 earnings. Prev 5 of 7 Next


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7 Parks near Foss, Oklahoma
Burns Flat, Oklahoma 4.78 miles SW
Canute, Oklahoma 9.79 miles NW
Cordell, Oklahoma 9.97 miles SE
Clinton, Oklahoma 11.3 miles NE
Foss, Oklahoma (map) | (580) 592-4433
Sites: 145 | Latest Rate: $27.00 | 35 Reviews
|Clean Restrooms:
|Clean Showers:
Oct 2015 - $27.00
We went for the full hook up sites which were on the opposite side of the park from the lake. Sites were level and were long enough for our camper and truck. The other sites were kind of close but we didn't spend much time there so it was okay.
If you want great views go for the lake side sites. They have hookups but no sewer.
Park itself was very nice and we would stay again. - John Borajkiewicz
Sep 2015 - $25.00
Cedar Point, which is in Foss State Park, is a beautiful campground right on the lake. We stayed here in site #1, which had a fabulous view, electric and water at the site, a nice level cement pad, a spacious grassy area, park bench and grill. There's a dump station on the way out, which we used.
The grounds are actually quite big and there are places for group picnics, a frisbee golf course, etc. A small marina is within walking distance and in the Summer a restaurant is open (we missed getting to try it out as it was already closed for the season).
It was a peaceful location. We'll return to this spot if passing through again. - Ree Klein
Aug 2015 - $22.00
We were coming in on a weekend, and the ranger suggested we go to the North part of the lake, as the Southern part campgrounds fill up faster. We found a number of available sites, with 50 amp, and even a view of the lake. There were concrete pads to park on and sites had to use the dumpstation when leaving. It was very quiet at night, despite many campers and RVs in the area. There are no nearby stores for shopping, other than a bait store or two. We enjoyed our stopover. - elduque
Canute, Oklahoma (map) | (580) 592-4409
Sites: 102 | Latest Rate: $43.00 | 83 Reviews
|Clean Restrooms:
|Clean Showers:
Jul 2016 - $43.00
When going through Oklahoma on I-40 W, we have stayed at several other rv parks. This is the nicest in the Elk City area. The rate listed is for 3 adults. The help is extremely friendly and helpful. The RV park is nicely shaded and easy to navigate. Full hookups work well. Nice pool behind the office. They just built a huge dog park in the back of the RV park. Sites are very clean and level. The numerous shade trees are cut high enough so motorhomes/campers do not scrape the limbs. WiFi was excellent. They do have cable but it was fuzzy...used our satellite. We will stay here again on our next trip through. - User2396
Jun 2016 - $42.00
The best KOA we visited. This was one clean campground. There were 2 areas for pets along with bags to use to clean up after your pet. The pool area was very clean. The cafe' was like being at a neighborhood pub, very friendly and relaxing. To say the entire staff was pleasant is an understatement! - NancyT
May 2016 - $41.00
The facility was clean and staff was friendly. The campground is right off the freeway and there is nothing nearby worth seeing. The grass/gravel parking areas are fairly level and the hookups are in good repair. However the cable and Wi-Fi did not work. Even though we contacted the office and they said they would reboot the modem. It still did not work. The cable did not work for us nor for our neighbors. OK for a stopover while traveling. - vtaylor
Clinton, Oklahoma (map) | (580) 323-1664
Sites: 50 | Latest Rate: $30.00 | 2 Reviews
|Clean Restrooms:
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Sep 2013 - $30.00
We got by for one night but would not stay here again except as a last resort. Very crowded with oilfield workers. Quiet but not attractive at all. Just a place to stop and sleep. We would only stay here again if there were no other choice. - nitronorton
Dec 2006 - $22.00
This is an older park, but was quite well kept up. This was our port in a storm after strong winds tried to take our awning off, we stopped here for one night. There are pecan trees throughout, and it looks like there are some long term campers here, but on the whole is clean and well kept up. - Sid
102 Allee Dr Elk City, Oklahoma 73644 (map) | (580) 225-4888
Sites: 50 | Latest Rate: $28.00 | 18 Reviews
|Clean Restrooms:
|Clean Showers:
Mar 2016 - $28.00
Very good instructions for late arrivals. Be careful of directions to them, as without escort to short term sites, turns can be confusing. Short term sites level, long and defined. We enjoyed our overnight visit. - SDCampowneroperator
Mar 2015 - $35.00
Well, I'd have to say this place was terrible. It is by far the worst campground I've been to. The rest rooms if you like to call them that were absolutely filthy. It was disturbing how unclean, and vile they were. The cheap linoleum was coming off the floors. There was absolutely no toilet paper, and on arrival we were told there was no hot water. Not that you would want to take a shower there. Since the shower floors were absolutely filthy and not fit for a dog to be in. Thankfully Love's is across the street, and their bathrooms were clean. There is no cable, and wifi is non-existent. If your looking for a quick overnight, and don't need to use the bathroom or shower then this your place, if you do avoid this place at all cost! - JayC90
Apr 2013 - $25.00
Military discount applied. Park was full. 50 amp was missing one leg, mgr said "It worked last night" and didn't offer any help. CableTV did not work, again mgr offered no help. All sewer connections were missing lids. Pull-through site #49 was obviously only for pop-up tent trailers, we had to back out of the site. Park is for sale and apparently is not being maintained. Wi-Fi was intermittent. When checking in we got a receipt and verbal directions to find our site (that were wrong) and when we asked for the Wi-Fi access code the manager said "there it is on the whiteboard (barely readable), I don't know nothing about computers". Access road is directly behind the Loves Travel Park and access is single lane, I had to move for an entering school bus. We would never stay at this park again! - NorCal Dan
1016 Airport Industrial road, Elk City, OK 73644 Elk City, Oklahoma 73644 (map) | 580-243-7692
Sites: 35 | 0 Reviews
Elk City, Oklahoma (map) | (580) 225-7865
Sites: 74 | Latest Rate: $33.00 | 83 Reviews
|Clean Restrooms:
|Clean Showers:
Jun 2016 - $33.00
Found this RV Park on a billboard off of the interstate, called them to see if they have a spot available for one night, they did. I headed their direction. Their base rate for 30 amp is $33 a night -10% discount for good Sam, AAA, and other various clubs. Not sure how much the 50 amp is per night but I think it might be $38 a night.
They have two Wi-Fi towers available for no charge, they have two bath houses, they have cable television at every campsite and it's close to local markets to pick up various items - Denise M Smith
Jun 2016 - $32.00
Echoing what others have said with the exception of the bathrooms. Each bathroom contains a toilet, sink and shower which was realy nice, but the one I used was dirty and needed a good deep cleaning. Dead bugs on the floor and no hot water in shower. Office was closed so could not report it. - Wndopdlr1
Oct 2015 - $28.00
Good level gravel sites that are close together. Wi-Fi was spotty and cable was average. Showers and laundry very clean and nice. Interstate was close and you could hear it early in the morning. Good for an overnight stay. - Biggyrat
Washington Ave Elk City, Oklahoma 73644 (map) | (580) 225-3230
Sites: 5 | Latest Rate: $1.00 | 3 Reviews
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Jul 2016 - $1.00
This is a small City Park that has five RV sites which are free on a first come, first serve basis for a max stay of four nights. The park is clean and well kept. Each site has a fairly level asphalt pad with grassy areas between the sites. There is thirty amp electric with water available at one spot to fill up your tank if needed, but I understand this is shut off in the winter. No sewer and no dump station. There is a bathroom located at the picnic area, but we did not go in, so I can't say if it were clean it not. Based on the overall cleanliness of the park, I would imagine they were clean. There is a pretty little lake that had a couple of boaters. The park is located in a quiet area. The lady who gave us directions was very nice and helpful. - PaLa
Dec 2015 - $1.00
This was a beautiful little park that is first come first served but is free to use. There is a lake with wildlife. The setting is so pretty and serene, quiet. We have a 35' motorhome and while it took a bit of maneuvering, we were able to park comfortably. It is a level paved pad with grass next to you. There was electric, but in the winter no water. There is no dump, no services. except for nature. It is not set up for campfires or cooking. Maximum stay is 4 nights. I-40 is close, but you definitely don't hear it. Woman I called to inquire about the park, was very nice, very helpful. We would go again. - dorcol
May 2015 - $1.00
This is a free RV park, maximum stay of 4 nights. The park is just outside town, and sits on a lake. Very Quiet and peaceful. No sewer or dump but there is 30 amp power and water. Easy access but sites might be short for long motorhomes with toads. - Soos


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SOE CEO drops next PlanetSide Next render
At this rate, we'll only need to wait a few more years for the whole game.
After letting a tiny piece of the still-unannounced PlanetSide Next slip out last weekend, SOE CEO John Smedley's tweeted out another bite for us to chew on. This time, it appears to be a next-gen version of the Galaxy heavy troop transport. So yeah, marvel at it and stuff.
With any luck, a full unveiling of massively shooty MMO's not too far off. And if it is, well, it actually wouldn't be the first time something exactly like that has happened.
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For such a simple dish, creamed spinach can be a pain to make.
Picture this: after a long day at the office (or at the kids' soccer field or wherever) you turn the key to open your front door and you are greeted by the heady aroma of a steamy meaty stew.
Two days before Halloween and the festive spirit has caught up with you.
The Hitching Lot Farmers' Market in Columbus has officially closed for the season.
Don Stewart and his wife will be home with the lights on Halloween night, waiting for trick-or-treaters. But like a lot of folks who stock up on candy, they'll probably end up eating it themselves.
It's true... Despite what the kids think, not all Halloween treats need to rot your teeth on contact.
These earthy, hearty turnovers work equally well as a fall gathering appetizer and an easy weeknight meal.
Let's talk about one of the season's most iconic vegetables -- canned pumpkin.
Recently I went through my five cookbook shelves (each with about 50 books) and took some to the library for the book sale.
They may not seem old enough to be writing memoirs, but Hannah and Caroline Melby have been "on the road" since they attended elementary school in Starkville.
Admittedly, it sounds like a Halloween trick. Chocolate hummus.
America has rejected the idea of cappuccino-flavored Lay's potato chips.
After posting yet another disappointing quarter, McDonald's CEO Don Thompson said Tuesday the company hasn't been keeping up with the times and that changes are in store for its U.S. restaurants.
This easy, weeknight-friendly chicken dinner is a bit of a cultural mash-up.
In Columbus, I have noticed what I consider a high number of beekeepers and honey gatherers.
Spooky llamas and corn mazes aren't the only reasons I love Halloween, but they're some of the most recent.
I can't recall exactly when I gave up trying to make spaghetti that tasted like my mother's.
Now that you've cooked all of your sweet potato leaves with last week's recipes, it's time to get to the tuber itself.
Have you listened to your body lately? Is your perspective on food clouded by years of dieting and food myths?
I'd said I was going to write about sweet potatoes for this week. They are everywhere right now and very important to Southern cooking. However, I have come across references to cooking with sweet potato leaves twice in the past week so thought that this is a trend we in the Golden Triangle can jump on and leave kale far behind.
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1. Go crackers: An artisan baker's ingenuity opens new doors FOOD
2. Anne's Kitchen: From a Southern kitchen FOOD
3. Scrambled eggs baked in muffin tins make mornings easier FOOD
4. Cooking on deadline: Asian beef-and-mushroom burgers FOOD


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Cunningham Park
Freshwater Wetlands in New York City - Cunningham Park
New York City once contained 224,000 acres of freshwater wetland. This valuable ecosystem can slow erosion, prevent flooding by retaining storm waters, filter and…Read More
Long Island Motor Parkway
The Long Island Motor Parkway, also known as the Vanderbilt Motor Parkway, survives today as a bicycle path, but began as America's first limited-access road for…Read More
Redwood Playground
Redwood trees (Sequoia sempervirens) are the tallest trees on earth, often reaching heights of more than 300 feet and measuring 10 to 20 feet in diameter. They take 400…Read More
Sy Spyler Field
Only a few months after he was married, Sy Spyler (1937-1998) began coaching Little League baseball, and he continued to volunteer for over 35 years. Most of those years…Read More
The Forests of New York City - Cunningham Park
There are roughly 1,000 acres of forest in Queens, which are divided almost evenly between Forest, Cunningham, and Alley Pond Parks. All three parks in Queens are on the…Read More
Vanderbilt Motor Parkway
The Vanderbilt Motor Parkway, also known as Long Island Motor Parkway, survives today as a bicycle path, but began as America's first all-elevated road for cars.…Read More
W. Arthur Cunningham Statue
This sculpture bust of City Comptroller, W. Arthur Cunningham (1894-1934) is by Emil Sieburn (1888-1942). The subject was a rising star in the political realm of the…Read More
Directions to Cunningham Park
Cunningham Park Weather
- Queens Park Supervisor Goes "Beyond The Call"
- Coming Soon To Our Parks: Mountain Biking!
- NYRR Open Run: Cunningham Park
- Movie Night: Good Morning, Vietnam
- Shakespeare in the Park: As You Like It
- NYRR Open Run: Cunningham Park
- Movie Night: The Mouse That Roared


text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 1, 2011
|Filing date
|Aug 28, 2006
|Priority date
|Feb 3, 2006
|Fee status
|Also published as
|Publication number
|Theodore Aaron Litovitz, Andrea Lynn Cohen, Patrick Mehl
|Original Assignee
|The Catholic University Of America
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (7), Non-Patent Citations (29), Classifications (10), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a divisional of U.S. application Ser. No. 11/346,179 filed Feb. 3, 2006. The entire disclosure and contents of the above patents and applications are hereby incorporated by reference.
1. Field of the Invention
The present invention relates generally to treating individuals with ionizing radiation and other treatments of disease.
2. Related Art
The permanent damage caused by ionizing radiation is generally believed to be directly proportional to the dose of radiation. However, an increasing body of evidence has suggested that this model is not appropriate for estimating permanent damage from low dose radiation (LDR) exposure. In fact, the growing body of evidence indicates that LDR induces protection against subsequent high dose ionizing radiation (HDR) exposure. For example, a number of epidemiology studies have shown lower cancer rates for individuals exposed to low doses of radiation (see Cohen, B. L., Health Phys., 68:157-174, 1995; Miller. et al., N. Engl. J. Med., 321:1285-1289, 1989; Cardis et al., Radiat. Res. 142:117-132, 1995). These epidemiological results are supported by in vitro studies that show LDR exposure reduces damage from high-dose radiation (HDR) exposures (referred to in the art as radio-adaptation or hormesis).
The concept of radio-adaptation was first explored in vitro by Olivieri et al., who showed that lymphocytes that had been chronically LDR irradiated were less susceptible to chromatid aberrations from subsequent high dose x-ray exposure (see Olivieri et al., Science, 223:594-597 1984). This finding was confirmed for acute LDR, i.e. short term exposures low dose x-radiation, where LDR-exposed cells, following HDR exposure, showed enhanced survival and fewer chromosome breaks than controls (see Wolff, S., Mutation Research, 358:135-142, 1996).
Results from other studies are consistent with these findings (see Azzam et al., Radiat. Res., 138 (1 Suppl):S28-31, 1994; Azzam et al., Radiat. Res., 146(4):369-73,1996; Shadley et al., Radiation Research, 111(3):511-517, 1987.; Shadley and Wolff, Mutagenesis, 2(2):95-6, 1987; Shadley and Wiencke, Int. J. Radiat. Biol., 56(1):107-118, 1989; and Sanderson and Morley, Mutat. Res., 164(6):347-51, 1986). As a result, it is increasingly becoming accepted that LDR exposures triggers protective cellular mechanisms that induce a radio-adaptive response (e.g. reduce the killing rate of ionizing high dose radiation). In other words, LDR exposure that triggers these protective cellular mechanisms can impede the ability to effectively treat target cells with a subsequent lethal dose of HDR. However, the inventors of the present invention have recently discovered, contrary to what is taught in the biomedical literature, that under certain conditions, LDR and other stressors may be used to increase the killing rate of HDR therapeutic exposures.
According to a first broad aspect of the present invention, there is provided a method comprising the following steps: (a) providing LDR-sensitized cells of an individual; and (b) subjecting the LDR-sensitized cells to a therapeutic treatment that kills or modifies the functioning at least some of the LDR-sensitized cells.
According to a second broad aspect of the present invention, there is provided a method comprising the following steps: (a) providing sensitized cells of an individual; and (b) subjecting the sensitized cells to a therapeutic treatment that kills or modifies the functioning of at least some of the sensitized cells, wherein the level of one or more heat shock proteins in the sensitized cells are below the constitutive level of the one or more heat shock proteins for the cells.
According to a third broad aspect of the present invention, there is provided a method comprising the following steps: (a) providing maximally sensitized cells of an individual; and (b) subjecting the maximally sensitized cells to a therapeutic treatment that kills or modifies the functioning at least some of the sensitized cells.
The invention will be described in conjunction with the accompanying drawings, in which:
It is advantageous to define several terms before describing the invention. It should be appreciated that the following definitions are used throughout this application.
For the purposes of the present invention, the term "administer" refers to any common way, orally, topically, by a focused or unfocused exposure to a radiation source, etc. For example LDR and HDR may be administered by exposure to a source of X-ray or other type of ionizing radiation. Chemotherapeutic agents may be administered by intravenous injection.
For the purposes of the present invention, the term "cancer" refers to any type of cancer including, but not limited to, skin cancer, breast cancer, bowel cancer and prostate cancer.
For the purposes of the present invention, the term "cells" refers to cells either in vivo or in vitro. Cells may be part of a tissue culture, or present in an individual or an animal, etc. Cells may also include bacteria, viruses, prions, etc.
For the purposes of the present invention, the term "chemotherapeutic agents" refers to any chemotherapeutic or cytotoxic agents including, but not limited to taxol and cisplatin.
For the purposes of the present invention, the term "chemotherapeutic treatment" or "chemotherapy" refers to treatment of an individual with a chemotherapeutic agent such aschemotherapy treatments for cancer.
For the purposes of the present invention, the term "constitutive levels" refers to the levels (concentrations) of heat shock proteins in a cell prior to a treatment with LDR or other stress in accordance with the present invention, i.e. the normal levels of heat shock proteins in the cells Until sensitized cells have recovered at least 90% of their constitutive levels of Hsps, the sensitized cells are considered substantially sensitized.
For the purposes of the present invention, the term "down-regulate" the stress response is a synonym for "the inhibition of the stress response".
For the purposes of the present invention, the term "heat shock protein" or "Hsp" refers to any stress induced protective molecules that are induced by a variety of environmental stresses such as heat, ionizing and non-ionizing radiation (including electromagnetic fields and time varying magnetic fields), toxic chemicals, hypoxia (low oxygen), incorrect glucose levels, heavy metals and amino acid analogs. An important protective cellular mechanism involves activation of a stress response related to the induction of heat shock proteins (Hsps). The Hsp family comprises proteins synthesized in response to oxidative stress, which can then provide cellular protection from subsequent damage. Hsp70/72 is the most widely inducible protein in this family. For example, heat induction of Hsps in lymphocytes prior to radiation delayed apoptosis (see Gordon et al., Arch. Surg., 132(12):1277-1282, 1997), and Hsp over-expression inhibited cell death following lethal x-ray exposure (see Park et al., Radiat. Res. 153(3):318-326, 2000). LDR exposure has been shown to enhance Hsp levels (see Nogami et al., Int. J. Radiat. Biol., 63(6): 775-783, 1993; and Melkonyan et al., Int. J. Rad. Biol., 68(3):277-280, 1995). Sato et al. also showed that low dose X-ray irradiation induces Hsps in the gastric mucosa (see., Physiol. Phys. Chem. & Med. NMR, 28:103-109, 1996), and others (see O'Rourke et al., Biochem. Soc. Trans., 20(1):74S, 1992) have presented evidence that LDR exposure induces Hsps in cultured myeloid leukemia and CHO cells. The entire contents and disclosures of the above documents are incorporated herein by reference.
For the purposes of the present invention, the term "high dose radiation" and "HDR" refers to any dose over 0.5 Gy or any dose that might be used therapeutically to kill cells.
For the purposes of the present invention, the term "individual" refers to a mammal such as a human being, monkey, chimpanzee, horse, dog, cat, etc.
For the purposes of the present invention, the term "ionizing radiation" refers to ionizing radiation from any source that is capable of ionizing atoms, molecules, etc. of a cell. Examples of ionizing radiation include: X-rays, ultraviolet light, gamma rays, alpha particles, beta particles, neutrons, etc. Depending on the wavelength, ultraviolet may be considered either ionizing or non-ionizing radiation.
For the purposes of the present invention, the term "LDR-sensitized" refers to cells that have been exposed to a sufficient amount of LDR for a sufficient time or dose to reduce the concentration of heat shock proteins in exposed cells by approximately 10% or more.
For the purposes of the present invention, the term "lethal dose" refers to a dose of radiation or any other therapeutic agent or modality that is capable of killing, or modifying the function of, one or more cells.
For the purposes of the present invention, the term "low dose radiation (LDR)" refers to a dose of ionizing radiation in the range of approximately 0.5 cGy to approximately 50 cGy. In one embodiment of the present invention, an LDR dose of 1 to 10 cGy may be used to LDR-sensitize cancer cells. Other dosages of LDR may be used in other embodiments of the present invention depending on the type of tissue to be treated, the disease to be treated, etc.
For the purposes of the present invention, the term "maximally sensitized" refers to cells that have been exposed to a sufficient amount of a weak stressor, such as LDR or an electromagnetic field, so that the levels for each of the heat shock proteins in the cells are less than about 10% of the constitutive levels of the respective heat shock proteins in the cells. In some embodiments, maximally sensitized cells may have a levels of heat shock proteins are each about 0% of the constitutive levels of the respective heat shock proteins in the cells.
For the purposes of the present invention, the term "modifies the functioning of a cell" refers to any alteration in the normal functioning of a cell. Examples of modifications include such modifications as: changing the proliferation rate of cells, etc.
For the purposes of the present invention, the term "sensitized" refers to cells that have been exposed to a sufficient amount of stress inducing agent to induce a stress response. Although the use of LDR to form sensitized cells is described extensively below, the present invention encompasses the use of other stress inducing agents to form sensitized cells.
For the purposes of the present invention, the term "stress inducing agent" refers to agents that induce a stress response. A stress inducing agent may be radiation-based such as LDR, non-ionizing radiation, etc. One source of non-ionizing radiation may be a laser beam. Depending on the application, ultraviolet light may be used either as LDR or as non -ionizing radiation. A stress inducing agent may also be non-radiation based such as toxic chemicals, heat, mechanical stress, etc. In one embodiment, the stress inducing agent may be electromagnetic radiation
For the purposes of the present invention, the term "stress response" refers to a temporary reduction of heat shock protein by approximately 10% or more that is usually followed by an increase, above constitutive values, in the level of heat shock proteins.
For the purposes of the present invention, the term "weak stressor" refers to a stress-inducing agent that turns on the stress response of a cell, but kills either no cells or a negligible fraction of the cells exposed to the weak stressor. Examples of weak stressors include: both ionizing and non-ionizing electromagnetic radiation including: LDR, gamma-rays, X-rays, ultraviolet light, infrared radiation, laser light, microwaves, radio waves, etc.; ultrasound; time varying magnetic fields; chemical agents including various pharmaceuticals and toxic chemicals such as: chemotherapeutic agents, arsenic, etc.; increases or decreases in temperature of several degrees centigrade; mechanical stress, biological agents etc.
For the purposes of the present invention, the term "therapeutic agent" refers to any agent or procedure such as radiation, chemicals used in chemotherapy, pharmaceuticals, etc. that may be used: to modify the functioning of, to reduce the number of or to prevent the proliferation of the cells that are the target of a therapeutic treatment.
For the purposes of the present invention, the term "therapeutic treatment" refers to the administering of a therapeutic agent to an individual in a dosage or manner sufficient to reduce the number of one or more types of cells or to prevent the proliferation of one or more types of cells.
For the purposes of the present invention, the term "therapeutically effective amount" refers to an amount of a therapeutic agent capable of inhibiting the functioning or proliferation of cells and or reducing the number of living cells.
For the purposes of the present invention, the term "tumor" refers to any type of tumor including both malignant and non-malignant tumors and any abnormal proliferation of cells.
Where the definition of terms departs from the commonly used meaning of the term, applicant intends to utilize the definitions provided above, unless specifically indicated.
The present invention uses low-dose radiation, and other stressors, to enhance the effectiveness of subsequent high dose ionizing radiation and other therapeutic interventions such as chemotherapy.
Radioadaptive response is the name for an observed reduced effect after exposure to a higher challenging dose (e.g. 4 Gy) when a previous priming (or preconditioning) dose (e.g. 1 cGy) was given 4 to 7 hours earlier. Hsp induction as a primary mechanism involved in radio-adaptation has been suggested. Park et al. and Lee et al. disclose studies where cell lines that did not previously exhibit a radio-adaptive response were made to over-express Hsp72 (see Park et al., Radiat. Res., 153(3):318-326, 2000; and Lee et al., Cell Stress Chaperones, 6:273-281, 2001).
Over-expression of Hsps in the cells yielded a restoration of the radio-adaptive response. Thus many papers in the literature teach that the exposure to LDR induces a radioadaptive response (i.e. exposure to LDR makes cells less sensitive to subsequent HDR). In contrast, according to one embodiment of the present invention, conditions are provided under which LDR can make cells more sensitive to subsequent HDR.
When heat shock is applied, it has also been theoretically predicted (but not experimentally proven) that Hsp levels are temporarily lowered as a result. Peper et al., theoretically predict that the protection against stress might drop rapidly (i.e. within several minutes) following heat shock and that this drop lasts about 3 hours before rapidly returning to pre-conditioning levels (see Peper et al., Int. J. Hyperthermia, 14(1):97-124. 1998).
Because the literature also suggests that LDR exposures induce Hsps, the inventors hypothesize that the induction of Hsp may play a role in the LDR pre-conditioning phenomenon which, the inventors have discovered, may induce de-protection against ionizing radiation In fact, the literature teaches away from our discovery by indicating that LDR exposure either has no effect or induces protection against ionizing radiation and that the induction of heat shock proteins is an important contributor to LDR-induced protection against ionizing radiation.
What has been surprisingly discovered by the inventors is that subjecting target cells (e.g., of an individual) to LDR and then waiting for times ranging from 1 minute or less to 2 hours or more, depending on the nature of the target cells, can cause those cells to be temporarily sensitized to the beneficial effects of subsequent treatment of these sensitized cells with a lethal dose of HDR or a chemotherapeutic agent. Without being bound by theory, it is believed that this sensitization of the cells subjected to LDR causes constitutive Hsp in the cells to temporarily bind Hsp to the damage sites induced by the LDR and therefore for a period of time (until new Hsp can be produced) the cell radioprotection mechanisms against HDR or other stresses are therefore reduced until the normal production of Hsps coming in about 3 hours after LDR exposure would then protect the cells against the lethal effects of subsequently subjecting the cells to a lethal dose of HDR or chemotherapeutic agent or other stress.
Because this sensitizing effect of the LDR is temporary (e.g., will dissipate over time, and typically gradually over a period of about 20 minutes to 2 hours (depending on the nature of the cell) after the cell is subjected to LDR), in one embodiment of the present invention, LDR-sensitized cells are subjected to the subsequent lethal dose of HDR, a chemotherapeutic agent or any other potentially lethal stress while these cells are still substantially LDR-sensitized. Thus, the HDR, chemotherapeutic agent or other lethal stress are preferably applied within approximately 1 minute to approximately 2 hours depending on the nature of the cells.
Depending on the cells being exposed to LDR, constitutive levels of Hsps in the cells will generally be recovered in approximately 2 to 3 hours, in some cases somewhat less than 2 hours, after the cells have been LDR-sensitized to reduce the concentration of Hsps to less than 50% of constitutive levels preferably as close to 100% reduction as possible. Therapeutic treatments may be performed, in accordance with one embodiment of the present invention, at any time from the time when the cells being treated are LDR-sensitized up until the time the cells have recovered their constitutive levels of Hsps.
The duration of the LDR used may vary depending on the intensity of the radiation, the type of cells being treated, etc. In one embodiment the treated cells may be exposed to LDR for a time of less than approximately 10 minutes.
In addition to or instead of LDR, other stress inducing agents may be used to form sensitized cells in accordance with various embodiments of the present invention. For example, a source of non-ionizing radiation, such as a laser beam emitting visible or infrared radiation, may be used to sensitize cells. Ultraviolet light may be used either as LDR or as non-ionizing radiation to produce sensitized cells. Toxic chemicals, heat, mechanical stress, etc. may also be used to produce sensitized cells in accordance with various embodiments of the present invention.
In accordance with one embodiment of the present invention, apparatuses that may be used to administer HDR to treat tumors, cancers, etc. include, for example, typical therapeutic x-ray machines or linear accelerators in use in any hospital. Other ways of administering HDR include but are not limited to gamma ray sources and ultraviolet light sources.
In order to use the apparatuses described above to therapeutically treat cells with HDR in accordance with one embodiment of the present invention, no modifications need to be made to the apparatuses or how these apparatuses are normally used other than a reduction in the usual dose.
In accordance with one embodiment of the present invention, chemotherapy treatments that may be used to treat tumors, cancers, etc. include, the intravenous injection of such chemotherapeutic agents such as: taxol, cisplatin, bleomycin, or etoposide.
In order to use the above-described chemotherapeutic treatments in accordance with one embodiment of the present invention, various modifications may need to be made to these treatments. These modifications include a reduction in dose needed for killing the tumor cells.
In accordance with one embodiment of the present invention, other therapeutic treatments that may be enhanced include, but are not limited to: antibiotic or anti-viral treatment of acute or chronic infection, or therapeutic interventions related to parasitology. In fact, any treatment of diseased tissue or cells that would be enhanced by a reduction of the stress response of the diseased tissue or cells would benefit from our discovery that weak stressors can induce a time dependent reduction in the stress response.
In order to use the above-described other therapeutic treatments in accordance with one embodiment of the present invention, a modification may need to be made to these treatments. This modification includes a reduction in dose needed to kill the tumor tissue.
Enhancing the Killing Efficacy of Ionizing Radiation
When two identical areas of cells are selected for exposure to HDR, and when one of those two areas is exposed to LDR 3 or more hours prior to the HDR exposure, then it has been observed that the survival rate of that LDR exposed area is higher than the survival rate of the cells in the unexposed area. This indicates that cells exposure first to LDR before exposure to HDR will increase the survival rate of cells exposed to HDR, thus indicating that those cells would be harder to kill after such exposure to LDR. This is an expected result, as taught by prior art.
Unexpectedly, given the same two areas of cells described in the previous paragraph, in one embodiment of the present invention, when one area of cells is first exposed to LDR to form LDR-sensitized cells and then exposed to HDR within several minutes to 2.5 hours, the survival rate of cells in that LDR exposed area of cells is lower than the survival rate of the untreated area of cells. This indicates that cells can be treated to be more sensitive (i.e. more easy to kill) to HDR and other stresses such as toxic chemicals by first exposing those cells to LDR at least 2.5 hours prior to exposure to HDR or other stresses. The preferred time window in which LDR-sensitized cells are exposed to HDR may vary by type of cells and type of tissue being treated. For example, in some types of tissue, such as cancer cells and breast cancer cells, the time window for HDR treatment may be 20 minutes to 1 hour after the cells in the tissue are sensitized with LDR.
Maximum de-protection was obtained at approximately 1� hours after the LDR exposure. This finding of an increased sensitivity of tissues to high dose radiation immediately, i.e. within 2 hours or less, following LDR exposure has profound implications for clinical radiotherapy and chemotherapy treatments. The potential for significant improvements in cancer outcomes following radiation and chemotherapeutic treatments appears to be high.
Thus if within about several minutes to 2 hours, depending on the type of tissue one wishes to destroy, prior to an application of a therapeutic dose of x-ray energy or other types of ionizing radiation or potentially lethal stress, a low dose of radiation (i.e. LDR) is applied, the destructive effect of the therapeutic dose (e.g. HDR) is enhanced.
A low dose may be about 10 cGy but may be as low as 0.5 cGy and as high as 50 cGy. The low dose may be chosen to cause an amount of damage to the cell which can be readily repaired by the cellular Hsp or other defense mechanisms. This amount of damage may be large enough to involve (in the repair process) as much of the constitutive level of Hsp as possible so that this Hsp will not be available to protect against the HDR.
Using LDR instead of heat shock as the initial conditioning stress, the data shows that Hsp levels are reduced. This result agrees with the Peper et al. prediction heat shock reduces Hsp levels temporarily but the details in timing of the resultant reduction differ significantly from the theoretical predictions of Peper et al. (see Peper et al., Int. J. Hyperthermia., 14(1):97-124, 1998).
The inventors have found that in some cells (e.g. chick embryos) the protection decreases slowly over a period of about 1.5 hours and then over the next 1.5 hours increases back to the non-preconditioned value. Thus it is found that peak de-protection occurs about 1.5 hours after LDR exposure, see
Enhancing the Killing Effect of Chemotherapeutic Agents
Focused LDR exposures may also be used in conjunction with chemotherapy where they have the advantage of being able to enhance the effect of the chemotherapeutic agent in a focused region of tissue, i.e. the tumor but not the normal tissue around it. In order to de-protect against stresses such as chemotherapeutic agents or any other lethal agent which act on the cells for hours instead of minutes, as is the case for ionizing radiation, the Hsp levels may be down-regulated for longer than 1 hour. To down-regulate the concentration of heat shock proteins for a period of more than 1 hour, LDR may be applied once a day for several days (preferably three to four days) prior to the use of chemotherapeutic agents. In this way the Hsp levels will remain down-regulated for many hours. This down regulation process may be explained as follows. When a stress is applied to a cell the level of Hsps is first decreased for about 2 hours (our invention in this application) and then after about three hours is increased. Finally after about ten hours this level returns to constitutive levels. The inventors have discovered that if one repeats this stress every day for about three days the process of adaptation to this stress occurs. Because of the adaptation process, after repeated daily stress, no Hsp are induced when the stress is applied.
All documents, patents, journal articles and other materials cited in the present application are hereby incorporated by reference.
Although the present invention has been fully described in conjunction with several embodiments thereof with reference to the accompanying drawings, it is to be understood that various changes and modifications may be apparent to those skilled in the art. Such changes and modifications are to be understood as included within the scope of the present invention as defined by the appended claims, unless they depart therefrom.
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|Olivieri, et al. "Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine", Science. vol. 223, pp. 594-597, Feb. 10, 1984.
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|Park, et al. "Inducible Heat-Shock Protein 70 Is Involved in the Radioadaptive Response". Radiation Research. 153, pp. 318-326, 2000.
|Peper, et al. "A mathematical model of the hsp70 regulation in the cell". Int. J. Hyperthermia. vol. 14, No. 1, pp. 97-124, 1998.
|Prolo, P et al. Neuroendocrine-immune surveillance of osteosarcoma: emerging hypothesis. Journal of Dental Research. Jun. 2003. 82(6): 417-421.
|Sadekova, S et al. Induction of PBP74/mortalin/Grp75, a member of the hsp70 family, by low doses of ionizing radiation: a possible role in induced radioresistance. Int. J. Radiat. Biol. 1997. 72(6): 653-660.
|Sanderson, et al. "Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation". Mutation Research. 164, pp. 347-351, 1986.
|Sato, et al. "Low Dose X-ray Irradiation Induces Stress Proteins But Does Not Prevent Gastric Mucosal Lesion", Physiol. Phys. Chem. & Med. NMR. 28, pp. 103-109, 1996.
|Seong, J et al. Adaptive response to ionizing radiation induced by low doses of gamma rays in human cell lines. Int. J. Radiation Oncology Biol. Phys. 1995. 33(4): 869-874.
|Shadley, et al. "Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes". Radiation Research. 111, pp. 511-517, 1987.
|Shadley, et al. "Induction of the adaptive response by X-rays is dependent on radiation intensity". Int. J. Radiat. Biol., vol. 56, No. 1, pp. 107-118, 1989.
|Shadley, et al. "Very low doses of C-rays can cause human lymphocytes to become less susceptible to ionizing radiation". Mutagenesis, vol. 2, No. 2, pp. 95-96, 1987.
|Supplementary European Search Report received in European Application No. 07763559.7, dated Nov. 11, 2009.
|Wolff, Sheldon. "Aspects of the adaptive response to very low doses of radiation and other agents". Mutation Research . 358, pp. 135-142, 1996.
|U.S. Classification
|607/1, 204/157.44, 435/325, 435/173.1
|International Classification
|Cooperative Classification
|European Classification
|Nov 16, 2010
Owner name: THE CATHOLIC UNIVERSITY OF AMERICA, DISTRICT OF CO
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LITOVITZ, THEODORE A.;COHEN, ANDREA L.;MEHL, PATRICK;SIGNING DATES FROM 20060124 TO 20060129;REEL/FRAME:025367/0976
|Aug 1, 2014
|Fee payment
Year of fee payment: 4


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The AbiWord word processor is a full-featured cross-platform word processor.31 weekly downloads


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Bring the beach home with nautical decor.
Your coupon will be applied to the highest regular-price, eligible item in your cart.
Offer good for one item at regular price only. Limit one coupon per customer per day. Must present coupon at time of purchase. Offer is not valid with any other coupon, discount or previous purchase. One cut or one bolt of fabric or trim "by the yard" equals one item. Online fabric & trim discount is limited to 10 yards, single cut. Excludes Heidi Swapp™ Minc.™ Foil Applicator, CRICUT® products, Tim Holtz® Vagabond™ Machine, Silhouette CAMEO® Machine, candy & snack products, gum & mints, helium tanks, gift cards, custom orders, special orders, labor, rentals or class fees. Cash Value 1/10¢.
Bring the beach home with nautical decor.
Craft fun in the sun with shell-worthy DIYs.
Summertime designs with a side of sunshine.
Look here for exciting designs.
Pretty blooms & leafy greens for big days.
Poolside goodies for a head-turning spread.
Art starts with creativity & inspiring supplies.
Crafty days call for crochet projects.
Keep kiddos movin' with toys, games and more.
Jewelry making is bolder in colorful shades.
Totes, hats and scarves for vacation time.
This Clear Crackled Glass Votive Holder Cup will add an elegant touch to existing decor with or without candlelight. Add a colorful candle for a touch of flair, or keep it simple and chic with a white or cream-colored candle--the choice is yours! Fill your ambiance with a beautiful crackled glow.
Please note: this candle holder is not designed to be free standing; place it in a sconce, taper holder, or other device designed to hold glass votive cups.
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"This is the second year we've bought these socks for our U11 team. Great value and long lasting!" (E3172)
"Product arrived on time and as ordered. " (E20347)
"Great product. The team love these shorts. A matter of fact i will be ordering some more." (E3018)
Epic Sports
All Goals 6'6"x12'x0'x6' 3mm Twisted Soccer Nets [E39643]


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I can set shipping classes for the shipping method 'flat rate', those classes I made with shipping to Holland in mind.
For other country's I activated international delivery. What I'm trying to achieve is that it calculates the costs of shipping to Holland (based on the right shipping class) + an additional 10 euro.
Is this possible?
Kind regards,


text:
SliemaView all 8 Hostels
Granny's Inn Hostel From US$19.82
Corner Hostel Malta From US$14.31
Balco Harmony Hostel From US$20.92
Hostel Jones From US$17.62
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Check out the Hostelworld.com selection of hostels in Malta. Read customer reviews of Malta hostels, view hostels on map of Malta and avail of free SMS confirmations. And why not check out our pick for the best things to see and do in Malta while you're there. Hostelworld.com - the definitive guide to Malta hostels.
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This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
Laburnum House Lodge Hotel2 Self rated
4 Sloway Lane, Highbridge, TA9 3RJ
Price FromView Rooms
- Good
- 11 guest reviews
"Great hotel would recomend to anyone,very friendly and obliging...."
"It was a quiet relaxed weekend for my family and l. For two nights . The rooms were very comfortable and clean - and surprisingly warm. The..."
"Nice people, quiet location, great country escape...."
"When dining/drinking I asked to charge the items to my room, I was suprised to find when checking out the hotel had already charged my debit..."
"Very good value for money. We are a mobility-impaired couple , both aged 91. Our room was not fitted with specialized equipment, but we use..."
About the hotel
Set in a beautiful region of Sedgemoor, next to the Bridgwater Bay Nature reserve, between the seaside town of Burnham-on-Sea and the historic market town of Bridgwater, and only 10 minutes from the M5 motorway, Laburnum House Lodge Hotel offers comfortable accommodation and is an ideal destination for individuals, couples, families and business guests alike. There are 60 en-suite rooms arranged in double, twin or family layouts, all with colour TV and tea & coffee making facilities, and car parking for 120 cars. Laburnum House is an ideal venue for corporate and outdoor events.
With 40 acres of ground, it is suitable for club events, shows, exhibitions, conferences and many diverse sports. Please note that our bar and restaurant is open subject to demand; and may therefore close early on some nights. There are three good restaurants/pubs within walkingdistance of our hotel. In the instance of our facilities beingclosed our staff will be delighted to provide you with directions, should you require local refreshment. Please visit our website for our Full Terms and Conditions. Please note that the hotel's usual range of facilities are not providedover the Christmas and New Year holiday period; please check with us prior to booking. Please also note that, out of the Summer holiday season, our SwimmingPool and Sauna may not be available. Please check with us prior to booking.
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- Family friendly
- Cots available , Interconnecting rooms available , Pets Allowed
- Other
- Wedding Licence , Ground floor bedrooms
- Parking (charges may apply)
- Car parking available onsite
- Business
- Wi-Fi Available , Meeting Facilities , Wi-Fi Available In Public Areas
- Dining
- Restaurant , Bar , Breakfast to go
- In room entertainment
- TV , Radio
- In room facilities
- Tea/Coffee making facilities in each room
- Leisure
- Tennis Courts , Snooker/Billiards , Fishing , Clay Pigeon Shooting
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- From 15:00 hours
- Until 10:00 hours
- 30/06/2014 to 30/06/2020 - We charge a one-off fee of £20.00 to accommodate dogs; up to two dogs (or similar) permitted per room. Other animals charged and accommodated at our discretion. Prices are less VAT; VAT is extra. The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are allowed
Customer Reviews
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55% would recommend it to a friend
Customer service
Food quality
Room quality
aburnum House Lodge Hotel
Great hotel would recomend to anyone,very friendly and obliging.
Poor cleanliness of room!
I had saw the rating of this hotel and chose to ignore it, as the booking was a last minute thing and price was preferred over quality.
However, only having paid £35.00 does not justify a spiders nest growing in the room . (16)
I am sorry to write this as the owner or what appeared to be the manager perhaps is a lovely man and friendly enough.
I was also slightly miffed by on arrival it was locked and no-one was present, I had to call the number and wait for someone to allow me to come in, and triple check the cheapness of the room.
With a bit of TLC the rooms and the bar could be lovely, however this hotel has seen it's day at present and needs amending ASAP if it is to still run a business.
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Mountain Goat Rare Breed Rye IPA(RETIRED)
RATINGS: 47 WEIGHTED AVG: 3.49/5 SEASONAL: Special IBU: 60 EST. CALORIES: 183 ABV: 6.1%
Rare Breed #4 is out and about. Now. Its a Rye IPA, kinda same same but different to our regular IPA, but we use 20% malted rye in the grist in addition to malted barley. Rye gives a rich nuttiness to the mouthfeel that complements the big hit of galaxy and cascade hops that follows. On the nose its all fruity hops tropical and zingy. The palate is full, bitter and rich the rye helping out with this. It clocks in at 6.1%abv, 60BUs Available at McCoppins, Slow Beer, Blackhearts & Sparrows and other discerning beery stores. Hope you like it!
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ASUS MeMO Pad FHD 10 Android tablet
The MeMO Pad FHD 10 is a solid tablet overall but performance in some graphically intense games is poor
Price$ 399.00 (AUD)
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Kathy Cassidy
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
Anthony Grifoni
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
Steph Mundell
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
Andrew Mitsi
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
Simon Harriott
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.
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n Route 563, Mullica Township: A detour will be in effect on the road between 7 a.m. and 6 p.m. today between Batsto/Weekstown and River roads for paving work.
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Cat Cafe: A Relaxing Time with Cats
The Voyagin team has screened this host. Learn more
There are many types of absurd cafes in Japan. Maid Cafe is one of them, but Cat Cafe is surely one of the most ridiculous and enjoyable ones out there today! At "Cat Cafe", customers are able to have a cup of coffee while playing with a bunch of adorable cats. You can observe the sleeping cats. Play with the cats. Give them snacks. Your choice!
Its uniqueness has also given the cafe a lot of media coverage, and is, today, one of the most talked about places in Japan! With this plan, you"re able to be, play, and take pictures with the cats for an hour!
Go and relax with the cats now!
(Fee includes entrance fee. Drink and foods are extra.)
1 hour
Important Information
Booking required in advance 2days before
What you need to bring
1 - 10


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Democracy is being allowed to vote for the candidate you dislike least.
HTS costs up to $300 a month to operate. We need your help!
I don't even remember what even happen but what ever thanks for caring about me.
CP, i think tangled heart was talking to me...
Ok, I want to learn very much, I dont ask for you to show me cuz your probably busy, but can you tell me how to start?
share skills?:)
hey bro , get back to me on email@example.com maybe we can do besiness togheter.
Hey dude, Want to share skills with me? ;), I'm quite a bigginer.


text:
Rally against hate
Date: 5/27/2011 Album ID: 1257087
More than 30 people waved rainbow-colored flags and held signs at a rally against "hate crimes" Friday in front of the El Paso County Courthouse. The rally was in response to the gang beating of Lionel Martinez, 22, who was assaulted by a group of men on May 7 while waiting for a ride outside the Old Plantation nightclub in Downtown El Paso. Photos by Ruben R Ramirez / El Paso Times.


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1991 Dodge Dakota Repair and Maintenance
A guide to problems, costs, maintenance and repair for your 1991 Dodge Dakota
Verified by mechanics, reported by drivers like you
Ask a mechanic in our community
Never overpay. Check prices with our estimator
Our experts translate recalls into plain English
1991 Dodge Dakota Problems"No start" Caused By Failed Fuel Pump
Fuel pump failures are common on higher mileage models, Resulting in a crank no start condition.
On 3.7L V6 and 4.7L V8 engines the camshaft position sensor may fail causing the engine to crank but not start or it can cause intermittent stalling. A failed camshaft position sensor will require replacement.
If the threads strip where the front brake caliper mounts to the steering knuckle, a steering knuckle repair kit is available. A new steering knuckle is not normally necessary.
1991 Dodge Dakota QuestionsIt will start run good,then dies going down the road & won't restart for 30 min (1 answer)
after about 30 minutes it will restart and run good. Then dies again going about 5-10 miles, wait 30 or so minutes and restart good. I have had the computer box replaced, the coil replaced, tuned twice, plugs replaced & fuel filter replaced all by repair shop. What can I do now? Shop said not...
I have a 1991 dodge Dakota and for about a year it stalls whenever I hit the brake to stop. The other day it started and stalled within a few seconds and it won't start. I replaced the coil the one against the firewall and it still won't start any ideas in where to begin, unfortantly i do...


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When a pet is rescued from a burning building, seconds matter. Animals suffering from smoke inhalation require a special pet-sized oxygen mask to deliver life-giving air. Unfortunately, not all fire departments are equipped with these lifesaving devices.
By supplying our local fire departments with pet oxygen masks, we are directly saving the lives of beloved pets in our community.
The Ohio Valley SPCA is hosting a Valentine's Dinner/Oldies Dance on Feb. 8, 2013 at Generations in Fulton, with D.J. Bob Dorris. Enjoy your favorite classic hits while dining on tasty spaghetti marinara. An auction and raffle will round out the fun. The doors open at 5, with dinner served at 6:00. Tickets are just $15 (cash bar) and the proceeds will be used to purchase pet oxygen masks for our local fire departments.
Please note that reservations are required. Tickets can be purchased by calling[masked]-6963.
To learn more about the Ohio Valley SPCA, visit http://ohiovalleyspca.weebly.com/index.html. To learn more about the pet oxygen mask campaign, visit http://www.petsamerica.org/programs.html.
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This page requires a MaxPreps membership account.
Don't stress... It's free and easy to setup.
The Rockledge Raiders volleyball team won Monday's away non-conference match against Space Coast by a score of 3-0.
(October 3, 2011: Cocoa, FL 32927) In Monday's non-league contest, the Rockledge Raiders (Rockledge, FL) volleyball squad were winner over the host Space Coast Vipers (Cocoa, FL), by a margin of 3-0.
Next up, the Raiders face the Cocoa Tigers (Cocoa, FL) in a non-league contest, on Thursday, October 6. Rockledge will attempt to better on its 11-3 season record.
With the loss, Space Coast moves to 1-12 on the year. The Vipers travel to Cocoa (Cocoa, FL) to face the Tigers in a 4A District 8 contest on Tuesday, October 4. The Tigers go into the contest with a record of 1-12.


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I have been searching for a plugin for publishing my blogs to a facebook group and this one works fine. It will be perfect if someone can tell me how to disable the image or video option, as the majority of my blogs are text.
good works
Good work keep it up
the pu in is amazing
nice work
good plugin
You must log in to submit a review. You can also log in or register using the form near the top of this page.


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I got the new 2014 fly team 17.5. Everything was great. No shipping issues. No damage. For the most part only a couple things needed extra tightening. Bike rides awesome. Comes with xrp pro sl not team sl. These are 400 grams heavier but are wider and rear is 32 hole. This is better for me as I ride rough stuff daily.
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