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|ESPN: SportsNation
Let;s get rolling everyone.
Hey Bill. Enjoy reading the chats and blogs very much. As a KC fan, do you see Bruce Arians as a HC possibility and how about trading for Cousins or Matt Flynn?
Thanks ... I like Arians as a possible Chiefs' candidate a lot. I think a look at Cousins could be smart, too. It's not a great rookie class. It might be worth a third-round pick.
Do you think the NFL would move to a larger playoff bracket? I feel like the system they already have is perfect!
Look at the blog. We did a poll today. We hated it 9-1. I was part of the majority.
Can the Patriots be beat? They looked pretty incredible on Monday night!
Sure, they've been beaten three times this season. But they will be very dififuclt to beat in the postseason. The defense seems better.
with the QB class not being up to last years standards, what should the chiefs do trade back or take best overall player at # 1?
Well, I don't think the trade market will be hot because there no great QBs. So, I think its best available player.
What would you think about Denver hosting a Superbowl?Think it will ever happen without a dome?
I used to live in Denver. It can be great in the first week of Feb. It can also be really dang cold. Risky, but I think the city and stadium would be a great host.
Bill do you believe Peyton deserves the MVP this season? Brady seems to have catapulted past him last week, for a performance against a Texans defense that had already been handled by the likes of Chad Heene for 4 TD's and Aaron Rogers for 6 TD's.
We just had a poll and I voted for Manning. It's close. Both he and Brady are having great years.
How much longer can Phillip Rivers under perform and accomplish very little, before he is no longer considered an elite quarterback?
Well, i don't think he is considered an elite QB anymore because of the last two seasons. But I think he can still be a good player for four-six more years if a better supporting cast.
Okay so what issues would Kansas City have by signing Michael Vick, I think he's still a good quarterback, and although inconsistent, the team needs somebody who can make plays, not a "get her done" type quarterback like Alex Smith who runs an offense. Kansas City's problem is scoring and I think Michael Vick could do that. Plus getting to draft another defender would be nice.
I'm all for the Chiefs getting a birdge QB. I'm just not big on Vick fititng with that team. I think his better days are behind him.
What are the chances when sean Payton comes back to coach he goes else where? say, San Diego?
I'd say small.
BW, As a Charger fan this year has been up and down as far as the excitement level. I'm happy to see Norv and AJ finally getting walking papers. But as far as the draft goes we should end up with a top15 maybe even top10 pick this year. Id say that CB is the most pressing need defensively for us. Do you agree? And is there anyone that could be available in this range that would be worth the pick?
I think they need to look at an OL first and then decide the market as far as value goes. But that is the greatest need.
Hey Bill, I was wondering what you think the Raiders are going to do with Rolando? Any chance we see him get dealt to Jacksonville at the end of the season for some draft picks? Or will they simply cut him and take their loss?
Draft picks?Who would give anything more than late-round pick, especially with a big contract, for a guy who has been bad on the field and trouble off of it?My guess is he gets cut after the season.
Is this Ryan Matthews last year to prove himself in SD?
I think he gets next year. Then, oit be cut-bait time.
Which fan base would revolt more if the current brass is kept intact: KC or SD?
I'd say SD because the brass has been there longer.Neither would be thrilled, though.
The Chargers have had tons of injuries at all major positions on offense. If Norv wins out, doesn't he deserve another year with a healthy team?
Didn't we say that last year?
Is Jack Del Rio coaching in Denver next year? And how much longer will John Fox coach?
Just a guess, but I do think Del Rio will be back next year. As far as Fox, I'd say he stays as long as Manning does, at least.
New England and Denver are the hottest teams in the league right now. Is it inevitable that they meet again in January? If so, who comes out on top?
Depends on where it is played. Pats will be very difficult to beat on the road.
Norv is always blamed for the Chargers failures, but AJ Smith is the guy that let Vincent Jackson walk, traded up to get Matthews, and signed Meachem and Royal. Why doesn'the get more blame?
You are right and he does get his share of the blame. That's why they are both likely on their way out.
Do u believe the raiders should move to a 3-4 defense or stay in a 4-3....I think they have the players to move to 3-4 and it would help the secondary
I thought they would this year. It depends on their personnel next year, but it's a posisbility.
Are there any sexy picks at the top of the draft that could entice a team to overpay for the Chiefs #1 overall? Which teams might pursue? Thanks Bill, love your work!
I think that situation is still developing. I'd lean no. The best players are on defense and their is a lot of them, so the choices may mean teams want for one of those players to come to them.
Huge non-football breaking news: ESPN reports Josh Hamilton goes to Angels.
The Raiders just have to part ways with Knapp and Tarver after the season, right?
Maybe ... I think Knapp is more likely.
Well, both the Raiders and Grudne say no ... I beleive them.
With the 32nd pick in the 2013 NFL draft the San Diego Chargers select .... A late Norvember is under way and the Chargers will make a deep playoff run! Mark my words!!!
Would you take tebow over cassel or quinn
OK.On Tebow: Nah.
Is McFadden playing his final season in Oakland? If I recall correctly he is in a contract year and he hasn't been able to flourish into the star running back we need. Thoughts?
He has one more year. I'm not sure. I could see the team moving away from him because of the injuries. I think it will be a story to follow in the offseason.
When will the Broncos have competition within the AFC West again? Denver is the only team keeping this division from being the worst in NFL history.
I thought it was going to be this year. I mean, do any of the other three temas seem close?
Will Manti Te'o go # 1 to KC or will they go a different route?
I think he is one of the options, yes.
Could you see Oakland landing both Tracy Porter and Nnamdi next season assuming they are released?
They could be possibilites. i think both come available. Are either great?
How many more wins will it take for Dennis Allen to save his job? Every loss, his seat gets hotter. Us RaiderNation want stability, but 3-13 doesn't sound good, even if we are rebuilding.
That's up to Mark Davis. I think 3-13 would not make him pleased at all. Oakland needs to win against the Chiefs in their last home game. Another thing we haven't mentioned much, but the Raiders are 3-10 with a pretty easy schedule. That won't please Davis.
That's up to Mark Davis. I think 3-13 would not make him pleased at all. Oakland needs to win against the Chiefs in their last home game. Another thing we haven't mentioned much, but the Raiders are 3-10 with a pretty easy schedule. That won't please Davis.
WE have many teams that are having success in the Bay Area. The 49ers, Giants and Warriors all have documented friendships in the lockerroom. Do you think the buddy angle is overplayed or is it a factor?
You tell me, Brubaker.
Can T Jones really play corner? He isn't that big. Is he going to get sometime their this year?
I just don't know. He was drafted to be a explosive RB. Turning him into a CB seems desperate to me and he is the one who has brought it up.
Hi, Bill! Big fan. What do you think is the biggest key to the Broncos winning on Sunday? Thanks!
Thanks ... Playing a complete game. Better better in the first half and containing Rice.
I really think if SD wins out then Norv comes back. Didn't Spanos give him the game ball after the Steelers game?
He eneds to get to the playoffs. Faint chances.
Jacoby Ford. Do you see him staying a Raider after 2 seasons with foot injuries? He happens to be my favorite Raider receiver for what he accomplished with Gradkowski and Campbell under center.
He should get another chance next year to show he can get back to form. Very explosive.
How do you rank V. Miller as pass rusher compared to the better players you've covered the last 10 + years?
One og the very best. it's just not pass-rush. He is becoming a complete player. He will be one of the best defnsive players in the NFL for the next several years.
Bill, why isn't John Elway being mentioned as a frontrunner for Executive of the Year? He took a huge gamble on Manning and has drafted/signed free agents brilliantly. He seems to have made few mistakes, if any. John Fox for Coach of the Year also. I know he has Manning but the Defense is in the top 5 when they were at the bottom of the league when he took over. I think Denver Shoud have MVP, Defensive MVP, Comeback Player, Coach and Executive of the yer winners. I am biased though. Thoughts?
He will be in the conversation, I believe.
Marcus Allen and Bo Jackson played for the LA Raiders, both features on TV recently, is the NFL preparing the fans for the revival of the LA Raiders
Or just highlighting two great players.
Do you see the Broncos going after a running back with Mgahee nearing the end of his career? If so in the draft or FA?
Depends on Moreno. This is his chance to imrpess the team. They also have Hillman. But I could see another piece being part in in some form.
Bill - If the Raiders get a top 5 pick and Teo and Louteli are gone, will they draft the tackle from Texas AM..(best player available), i think they need a big man inside.
Gotta go with best defensive player.
Where do you see Cassel going next year? Just trying to latch on as a backup?
Yep, pretty much.
Hey Bill, who deserves to win the DPLOY award more Von Miller or JJ Watt?
Arkins might be in the mix.
How long will it take Mackenzie to turn things around in Oakland?
A couple nore years.
Are we pretty much looking at OL and CB heavy draft for San Diego? It would be nice to see the new GM actually draft kids from schools we've heard of.
They could use help nearly everwhere on offense and in the secondary.
A lot of bloggers are picking Peyton over Brady for MVP. Even though Brady has thrown less picks, what do you think gives Manning the edge in the MVP race?
Impact on the team.
Who of the following will be gone next year?Palmer, Seymour, Kelly, Lechler and Allen?
I'd say the most likely to go are Seymour, Kelly and Lechler.
What is your best guess percentage that McCoy will still be OC of Denver next year?
I think Carolina will come after him hard as head coach.
Any truth to the rumors that Oakland may move T. Jones from Rb to CB?
Not a rumor. He said he'd be open to it. It's up to the staff.
Do you think Matt Moore from Miami would be a good bridge in KC? He has proven capable of winning in Miami in limited starts.
He's OK. But casn he really help as a starter?
If you had to guess right now, what would the seeding in the AFC look like for the playoffs?
Just a guess:1. New E.2. Houston3. Den4 Balt5 Indy6. Cincy
Hue JAckson proved very capable at running an offense in OAK. Why do you think he hasn't been offered any coordinator positions?
I think he'll get some looks this offseason.
Great hour folks. Enjoy Week 15.


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8 reviews | 4.9 out of 5
My feet were hurting while working and using regular mens socks. So I ordered 2 pairs and as soon as I put them on I felt the difference. My feet weren't hurting and the smell was gone. Good product. Recommend to all construction workers out there who wear there boots all day.
20 yr old new job needed steel toe boots complained foot pain not complaining any more and he wore them once when not at work!
These are very good socks for the price. Thick cushion in the foot and the fit is true to size.
Excellent socks! great quality and very thick!
very happy with service

subset: commoncrawl


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Shock of Gray: The Aging of the World's Population and How It Pits Young against Old, Child against Parent, Worker against Boss, Company against Rival, and Nation against Nationby Ted Fishman
View All Available Formats & Editions
The New York Times bestselling author of China, Inc. reports on the astounding economic and political ramifications of an aging world.
The world's population is rapidly aging—by the year 2030, one billion people/b>/b>/b>/b>/b>/i>/b>/i>/i>/b>/i>/i>/b>/b>/i>/i>/i>/i>/i>/i>
The New York Times bestselling author of China, Inc. reports on the astounding economic and political ramifications of an aging world.
The world's population is rapidly aging—by the year 2030, one billion people will be sixty-five or older. As the ratio of the old to the young grows ever larger, global aging has gone critical: For the first time in history, the number of people over age fifty will be greater than those under age seventeen. Few of us understand the resulting massive effects on economies, jobs, and families. Everyone is touched by this issue—parents and children, rich and poor, retirees and workers—and now veteran journalist Ted C. Fishman masterfully and movingly explains how our world is being altered in ways no one ever expected.
What happens when too few young people must support older people? How do shrinking families cope with aging loved ones?
What happens when countries need millions of young workers but lack them? How do companies compete for young workers? Why, exactly, do they shed old workers?
How are entire industries being both created and destroyed by demographic change? How do communities and countries remake themselves for ever-growing populations of older citizens? Who will suffer? Who will benefit?
With vivid and witty reporting from American cities and around the world, and through compelling interviews with families, employers, workers, economists, gerontologists, government officials, health-care professionals, corporate executives, and small business owners, Fishman reveals the astonishing and interconnected effects of global aging, and why nations, cultures, and crucial human relationships are changing in this timely, brilliant, and important read.
Editorial Reviews
"Readers should consider its messages and economic implications. What do we really want for ourselves, as individuals and a nation, as we age....The true mission of "Shock of Gray" is a...call to confront the demographic drama now unfolding in many middle- and high-income countries, not to proffer solutions." -Los Angeles Times
"Who would've thought that America's aging population has spurred globalization? Ted Fishman's exciting book–a series of stories really–knocked me off balance as I learned what's in store for us as the world's populace grows older and older. The observations in Shock of Gray are not just revelatory but profound." -Alex Kotlowitz
"In 20 years, there will be 1 billion people over the age of 65, and China Inc.'s Ted Fishman has found the current examples that, along with an inexhaustible supply of demographic trends, illustrate the knotty-and at times terrifying-issues of global aging that await us. A must-read for young and old alike." - Fast Company
"The Chicago journalist behind China, Inc. is back with an investigation that's both timely and terrifying. The subtitle—"The Aging of the World's Population and How it Pits Young Against Old, Child Against Parent, Worker Against Boss, Company Against Rival, and Nation Against Nation"—says it all. (Though with his characteristic smarts, Fishman says it with a lot more nuance.)" -NewCityLit.com
Journalist Fishman (China, Inc.: How the Rise of the Next Superpower Challenges America and the World, 2006) takes a sober, in-depth look at the challenge of providing for an aging population.
By artfully juxtaposing anecdotal evidence of the lucky ones who have "cheated at the actuarial tables"—e.g., his 80-something mother who dances at swinging parties, and youthful 75-year-old retirees living it up in Florida, "God's Waiting Room"—with the dependent elderly unable to care for themselves, the author makes a convincing case that we must be prepared to pay a significant price for the increased longevity of the world's population. While not denying that a healthy lifestyle is an important factor in allowing an increasing number of people to enjoy an active life into their 70s and beyond, Fishman sees the extension of longevity as a problematic global phenomenon, primarily the result of abundant and reliable food, improved public-health measures and more accessible and effective antibiotics. An unintended consequence of a longer-lived population is the increase of the frail elderly, who will place an increasing burden on younger people who make up the workforce and who will be called upon as caregivers. While Europeans enjoy the benefit of early retirement and are reluctant to extend their working years, Americans over 55 are having increasing difficulty finding employment. At the same time, more women work outside the home, marry at a later age and are giving birth to fewer children. One answer would be for more older people to continue working, but under the pressures of globalization, Fishman sees the opposite tendency. Companies are driven by global competition to jettison older, higher-paid workers in order to drive down wages while lower-paid women are encouraged to join the workforce without adequate provision for childcare.
A timely wake-up call.
The New York Times
Product Details
- 9781416551027
- Publisher:
- Scribner
- Publication date:
- 10/19/2010
- Pages:
- 401
- Product dimensions:
- 6.00(w) x 9.10(h) x 1.40(d)
Meet the Author
Ted Fishman is a seasoned financial and economic journalist whose work has appeared in The New York Times Magazine, Money, Harper's, Esquire, USA TODAY, and GQ. He is featured frequently on many of the world's premiere broadcast news outlets. A Princeton graduate, Fishman is also a former floor trader and member of the Chicago Mercantile Exchange, where he ran his own derivatives arbitrage firm. He lives in Chicago.
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If age is just a number, then that number is about to present enormous global consequences in the next few decades. So says veteran journalist Ted C. Fishman in his around-the-world study of how an aging planetary population will affect all aspects of society, including business, government and family life. Fishman's in-depth study leans heavily on stories, anecdotes and conversations, backed by extensive statistics and impressive academic research. His tales are as entertaining as they are illuminating, pointing out the contradictions, foibles and hard realities of life lived on a graying globe. getAbstract highly recommends Fishman's all-encompassing look at old age - not just to older people or the middle-aged, but also to members of younger demographics, who are about to embark on an unprecedented journey with their elders into the future.
A fascinating look at the aging of our world. The implications are farther reaching than you could possibly imagine. I learned a lot,an excellent read.


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I like money and I like graphs. Money graphs.
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Show and tell for designers
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Does Indiana need 2 primaries?
The downside? Taxpayers must foot the bill.
The downside? Taxpayers must foot the bill.
The combine has been in Indianapolis since 1987.
Pence had cited concerns following the deadly Paris terrorist attacks when issuing the order in November.
ISP troopers reported smelling marijuana in the suspects' Dodge Durango.
Witnesses said two groups of people made arrangements to meet and fight.
The northwest Indiana environmental group Dunes Action! brought the bundles of signatures to the Republican governor's office Monday.
The measure passed Monday on a 7-4 vote.
Police say Cordero Pinex shot and killed 30-year-old Joshua Neloms in June 2015.
Some moments just have to be watched over and over again! That was the case for 2016, as we started the new year on Indy Style with plenty o…
The suspect is reportedly in custody, Madison Local Schools confirmed


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We know how to measure implementation effectiveness and productivity using a development backlog and concepts like Running Tested Features (RTF).
We know how to measure implementation effectiveness and productivity using a development backlog and concepts like Running Tested Features (RTF).
The importance of a well developed, force-ranked backlog of development priorities A couple of weeks ago I wrote about Agile software development off-shore. In that post I mentioned that the single most important item when planning and managing an Agile…
The people you hire is the single greatest investment you make. Accolo raised a Series B round in June of 2007 from Altos Ventures with three goals in mind:
We spend a lot of time talking to companies about what they want from their recruiting department, and a common phrase is "we want a candidate pipeline."
Accolo.com Now Packed with enhanced features and resources for executives, HR professionals and job seekers
Recently a job seeker had a bad experience while applying for a position supported by Accolo and posted a comment on Susan Ireland's Blog. Here is the comment and my response is below.
Upon joining Accolo last year, I felt I was walking into something a little scary and at the same time exhilarating, and as I've told many people over the years those are the two necessary ingredients when starting any new…
Risk management in hiring
Welcome to the new face of Accolo.
True end-to-end RPO HR Today listed Accolo as one of 13 companies who provide "true end-to-end RPO."
Let me be the first to break some news that you can't find anywhere else: a lot of people are looking for work right now. Really. I swear.
Accolo, Inc. has been named the Recruitment Process Outsourcer of the Year for 2005 at the HRO World Conference
A response to cash savings from outsourcing IT On a plane to San Diego, I had the good fortune of my laptop battery dying after its standard 30 minutes of life and opened the May issue of Inc magazine.


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wait for a good buying opportunity, smart money will drag it down and accumulate
Sbux is manipulated and will be manipulated down so as to accumulate
Sounds like it's going to be bad. Thanks for the heads-up.
YEAH, I HAVE BEEN THINKING THAT SINCE $63. WORST TRADE I NEVER MADE LOL ! seriously , I thought the Kraft settlement was going to take place at the end of August. So far not a word. They have exposure of 2.9 Billion but a more likely settlement would be around $1 Billion. to Kraft. I have seen a nice gain lost waiting for the legal system.
Sentiment: Strong Buy


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You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"i purchased the matching save the dates and added this to my envelope. made such a beautiful finishing touch to the already beautiful save the date!"
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Berkeley, CAUSA
December 10, 2013
Not very. I have some grasp of the basics (i.e. I can make sense of "A monad is just a monoid in the category of endofunctors"), but am seriously lacking of a systematic approach.
Lots of "here-and-there" reading on the interwebs; skimmed through Pierce's Types & Programming Languages book.
Some LISP (Scheme and Emacs lisp) awhile back, lots of Scala, some Haskell.
A programming languages enthusiast, with a strong interest in type theory and functional languages (esp. Scala and Haskell).
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Adoni Maropis
- Birthday
- Jul 20, 1963
- Birthplace
- Pittsburgh, Pennsylvania
Bio: Born and raised in Burgettstown, Pennsylvania, a small town near Pittsburgh. He is the middle son of Petro and Despina Maropis and is very close to his brothers, Sam and Chris.Being an exceptional all-around athlete in high school (Burgettstown High-school in southwest Pennsylvania), it appeared Adoni would pursue a professional career in some sport. Turning down… More Bio: Born and raised in Burgettstown, Pennsylvania, a small town near Pittsburgh. He is the middle son of Petro and Despina Maropis and is very close to his brothers, Sam and Chris.Being an exceptional all-around athlete in high school (Burgettstown High-school in southwest Pennsylvania), it appeared Adoni would pursue a professional career in some sport. Turning down various athletic scholarships, he enrolled at West Virginia University and graduated magna cum laude with a Bachelor's Degree in Business Administration.But, from years of being entertained by Adoni's impromptu comedic performances and impersonations which began when he was a small child, his father, Petro, told him that the suit and tie of the business world would probably choke him to death and encouraged Adoni to give acting a shot. Surprised, yet intrigued at this suggestion, Adoni enrolled at a performing arts school, Point Park College (now a University) in Pittsburgh, and studied acting, dialects, singing, and a bit of dance.His first stage role was as a freshman, even though freshman weren't allowed to perform at the time, where they needed him as an "Arabian Carrier" in The Nutcracker Sweet. Not only did Adoni get to flex his muscles in that role, but he also played the "Jack-in-the-Box" in the same production. Some of his other memorable plays and musicals were: Working, Evita, Getting Out, You Can't Take it With You, and Little Shop of Horrors where he played the man-eating plant, "Audrey II." After three years of theatre at Point Park, with the help of his younger brother Chris, he headed for Hollywood.Although Adoni is truly blessed with a more than usual dose of athletic ability and creative talent, what truly makes Adoni stand out is that he is a Type 1 Diabetic, and has been since he was 18 months old. His parents were told he would be weak and sickly, and in and out of hospitals his whole life. Ultimately, a renowned diabetic specialist told his father that most likely Adoni would be dead by the age of 25. As Adoni puts it, "I get a kick out of someone saying I can't do it." This has been proven by his numerous athletic awards and championships throughout high-school and college which involved everything - strength, speed, quickness and finesse. The list includes: tennis, basketball, baseball, football, weightlifting, arm-wrestling, fitness, and his favorite pastime, which is table tennis (ping-pong). Adoni loves being creative with his workouts which involve only 30-45 minutes per day of either running, biking, aerobics, some martial arts, or what he calls his "unique, unnatural, yet truly natural Cirque du Soleil/Tarzan workout".Some of Adoni's diverse and memorable roles include: the flamboyant evil sorcerer, Quan Chi, in the TV show "Mortal Kombat: Conquest" (1998), the sarcastic undercover agent in The Gristle (2001), "Abu-Fayed," in Season 6 of the Fox hit series "24" (2001) and the regal falcon-man in Hidalgo (2004), starring Viggo Mortensen.An inspiration to the world, Adoni will tell you that the most important ingredients to success and happiness are - love, laughter, and fitness! He credits his family and a few good friends with supplying all three.
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While their approach is informal, the team at The Invitation Source has become known as the most professional when you need Thank You Cards done.
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By being watchful and providing feedback, the team at Elegance on Paper in Natick can help you get the most from your Save the Date Cards.
For a truly professional Invitations experience, make THE WEDDING CENTER in Natick your first choice when you're in the market for an invitation store.
Blue Vellum
The friendly staff at Blue Vellum would love to help you with Thank You Cards. Come find out why they're the best invitation store in town!
Princess Sharon
For a first rate invitation store in Natick that can handle your Invitations needs, make sure you go with Princess Sharon.
Yacanna Wedding
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Invitations by TS
For an innovative approach when it comes to Save the Date Cards, always make it Invitations by TS. This invitation store can do Rush Service as well.


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Zynev Male Enhancement Supplement Free Trial
Zynev Best Penis Enlargement and Male Virility Supplement: Are you suffering from different virility problems like low sex stamina and short libido size? Is your wife is not satisfied with your sex performance? Are you experiencing fatigue, muscle pain problems? Are you suffering from erection and endurance problems? You do need to worry about these problems because there… Read More »


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Two upstate New York newspapers refuse to acknowledge that they have published an openly anti-Semitic letter promoting conspiracy theories.
The Rudoren Test
For a prominent journalist such as Rudoren to endorse language that uses the words "Palestinian assailants" and "Palestinian attackers" is a welcome change. (Although ideally, we would prefer the term "terrorist.")
A Loop de Loop of Violence
I used to think a violent loop was something associated with dangerous roller coasters. But the New York Times looped me into a different understanding. In recent weeks, I've read in the pages of the Times how "Leaderless Palestinian Youth, Inspired by Social Media, Drive Rise in Violence in Israel" and how violent Palestinian music…
CNN's Anonymous Terrorist
CNN reports on a terrorist incident but fails to tell its readers who the seemingly anonymous terrorist was.
Facebooking with Jodi Rudoren
My Facebook "conversation" with NYT's Jodi Rudoren in which she used the term "basketball game scorecard" to describe coverage "out of kilter with reality."
Lawyer Suing Facebook: Social Media Has Social Responsibility
After filing a lawsuit, lawyer Nistana Darshan-Leitner wants to force Facebook to remove posts calling for the killing of Jews.
CNN's New Terror: "Other-Handism"
The media have an obligation to not only report what people are saying, but what is really happening on the ground. If one side is saying things that have no basis in fact, the media needs to expose this, not simply say "it depends who you ask," or "on the other hand….."
The Independent and "Israeli Occupation Forces"
The Independent writes that "Israeli occupation forces" have killed Palestinians, buying into Palestinian propaganda terminology.
Balfour Declaration Anniversary Erases Jewish Connection to Holy Land
As Palestinians protest on the anniversary of the Balfour Declaration, the Daily Mail omits the Jewish historical connection to Eretz Yisrael.
From JK Rowling to Helen Mirren, UK Artists Slam Cultural Boycott
The cultural boycott is the most insidious part of the BDS strategy against Israel. There is no pretense of economic or political pressure. The only aim of a cultural boycott is to proclaim that Israel has no place among the nations. And increasingly, British culture figures are having none of it. First, Harry Potter author…


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Does the DVI port work for anyone running Snow Leopard or Lion on Dell D630 laptop in a dock? I can use the VGA port just fine but I cannot use the DVI port for another monitor. I have tried both - 10.6.8 as well as 10.7.5. Is there a fix for this?
Does DVI Port work with SL or Lion on Dell D630 intel 1400x900?
Started by LostVampire, Feb 20 2013 04:56 PMd630 dell dvi display snow leopard lion notebook external dock
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Fresh-Cut Products Workshop: Maintaining Quality & Safety
20th Annual Workshop
September 13-15, 2016
Alumni & Visitors Center
UC Davis
Fresh-Cut Workshop 2016 Brochure (pdf)
Focus on Fresh-Cut
Fresh-cut products are fresh fruits and vegetables that have been prepared (cleaned, washed, sanitized, cut), packaged, and held under refrigeration until consumption. The fresh-cut sector continues to develop innovative and convenient products.
Consumers demand safe, high quality fresh-cut products that have extended shelf-life, but also good eating quality. These demands require that fresh-cut processors and handlers meet rigorous standards.
This workshop provides an intensive and substantive overview of many aspects of fresh-cut production, processing, packaging, distribution and quality assurance. Participants gain working knowledge of established and new procedures through topic-related sessions and demonstrations.
In 2016, the workshop will feature discussions on fresh-cut marketing, new packaging, product physiology, microbial control, and sensory evaluation. And our practical demonstration on the impact of temperature on packaged product quality reinforces all the temperature-related discussions.
The fresh-cut industry and this workshop have changed considerably over the past 20 years. Join us if you are new to the fresh-cut industry, or if you want updates on many topics important to the success of the fresh-cut fruit and vegetable sector.
Who Should Attend
The workshop is relevant to all levels of fresh-cut produce industry professionals—from small, local and regional produce processors to large businesses with nationwide distribution. Food scientists, food engineers, quality assurance personnel and new product development staff as well as representatives from research institutions, the restaurant and Institutional food industries, and equipment, packaging and ingredient suppliers will all benefit from attending.
Marketing & Consumer Issues
- Consumer perception of produce quality & safety
- Marketing trends in the fresh-cut category
Product Biology
- Physiology and biochemistry of fresh-cut products
- Respiration, ethylene production, wound reactions
Product Quality
- Nondestructive quality measurement
- Nutritional composition of fresh-cut products
- Sensory quality of fresh-cut products
- Treatments to maintain product quality
Product Preparation
- Technical aspects of processing equipment and selection
- Sanitary plant design and waste management
- Fruit and vegetable preparation procedures
Temperature Management
- Cooling and storage options
- Accurate temperature measurement
- Temperature control during transportation and distribution
- Impact of temperature on product quality and storage life
Microbiology & Sanitation
- Microorganisms of concern in fresh-cut products
- Water disinfection options
- GAP and GMP considerations for fresh-cut
- Irradiation and fresh-cut produce
- Produce traceability
Modified Atmospheres and Packaging
- Impact of MA on product quality and shelf-life
- MAP and temperature interactions
- Packaging selection for fresh-cut products
- New developments in fresh-cut packaging
Specific Fresh-cut Product Information
- Concurrent sessions on product groups include raw material quality, maturity, storage and handling; processing options, benefits of temperature, modified atmospheres, quality defects.
- Concurrent sessions will be videotaped and available for viewing later by workshop attendees.
Enrollment Information
Location, Dates and Time
The workshop will be held at the Buehler Alumni & Visitors Center, UC Davis, on September 13-15, 2016. Each day, the workshop will begin promptly at 8:00 a.m. (7:30 a.m. on Sept 15) and conclude between 5 - 5:30 p.m. The registration desk will open at 7:15 a.m. on Tuesday, Sept 13.
Enrollment Fee
$1150 includes all instruction, course materials, three lunches and morning and afternoon snacks and coffee breaks, plus an evening networking re-ception. Please enroll by September 2.
Accommodations & Parking
For hotel information please go to: www.yolocvb.org, and look under "Davis" for "Hotels & Inns." A valid UCD permit is required to park on campus. Daily Visitor Permits (VP) are available for $9.00 and may be purchased from permit dispensing machines located at the entrance to visitor parking lots.
If Your Plans Change
Refunds, less a $100 processing fee, will be granted if requested at least seven calendar days before the course begins. At that time,
The UC Davis Postharvest Technology Center reserves the right to cancel or reschedule courses and to change instructors. Every reasonable effort will be made to notify enrollees of changes or cancellations.
The University of California does not discriminate in any of its policies, procedures or practices. The University is an affirmative action/equal opportunity employer.
III International Conference on Fresh-cut Produce: Maintaining Quality & Safety
September 13-18, 2015
(this conference took the place of the fresh-cut workshop in 2015)
We have an excellent cadre of experienced instructors from academia and industry.
Todd Baggett, RedLine Solutions, Santa Clara, CA
Jeff Brandenburg, JSB Group, Greenfield, MA
Jeff Brecht, Dept. Horticultural Sciences, Univ. Florida
Marita Cantwell, Dept. Plant Sciences, UCD
Roberta Cook, Dept. Agric. & Resource Economics, UCD
Irwin Donis-González, Dept. Biol. Agric. Engineering, UCD
Rudi Groppe, Heinzen Manufacturing, Gilroy, CA
Deirdre Holcroft, Holcroft Postharvest Consulting, Davis, CA
Karan Khurana, Pulse Instruments, Van Nuys, CA
Elizabeth Mitcham, Dept. Plant Sciences, UCD
Anne Plotto, USDA-ARS, Fort Pierce, FL
Anuradha Prakash, Chapman University, Orange, CA
Mikal Saltveit, Dept. Plant Sciences, UCD
Trevor Suslow, Dept. Plant Sciences, UCD
James Thompson, Postharvest Engineering LLC, & Dept. of Biological and Agricultural Engineering UCD
Florence Zakharov, Dept. Plant Sciences, UCD
Faculty Coordinator & Technical Advisor
Enrollment is Easy!
Online using the convenient and secure online registration form.
By Phone by calling (530) 752-7672. Please have your Visa, MasterCard, Discover, or American Express account number handy.
By Fax by sending the complete enrollment form from the brochure to (530) 754-4326.
By Mail by completing the enrollment from from the brochure and mailing it with your credit card information, or check for $1150, to:
Attn: Penny Stockdale, Registration Desk
Postharvest Technology Center
UC Davis - Dept. of Plant Sciences - MS2
One Shields Avenue
Davis, CA 95616


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Scrumptious Pear Pie
Total Time
Prep 10 mins
Cook 45 mins
My MIL gave this recipe to me years ago. It's always been a huge hit with my family. Hope you enjoy it!
Ingredients Nutrition
- 2 cups pears
- 1 cup sugar
- 2 tablespoons flour
- 1 teaspoon vanilla
- 1⁄2 cup butter, divided in half and melted
- 2 pie crusts
- additional sugar, to sprinkle on top of pie
- Combine pears, sugar, flour, vanilla, and 1/2 stick melted butter.
- Pour in one pie shell.
- Cover with the other pie shell.
- Sprinkle with sugar and remaining 1/2 stick melted butter.
- Bake at 400 degrees for 45 minutes.
Most Helpful
Ah, a wonderful pie indeed. I really love single-crust pies with plenty of fruit, so I put a little foil lid on it to mimic the top crust and stop it drying out too much. Yes, the result looks a bit goofy, but it ended up tender and perfectly done. After reading some of the "soupy" comments I cut the butter back to two tablespoons, and then added a teaspoon of cardamom to punch it up a bit. It pairs beautifully with vanilla ice cream. My mom and sister and I mowed through more than half of it, and they said to feel free to bring this pie again when we have our next family dinner. Oh wait, I also subbed Splenda for the sugar and we never knew the difference. Thanks for a winner.
This pie was tasty, but I found it a little too sweet. I think I'd use less sugar next time. Other than that, I enjoyed it and will make it again.
This was my first attempt at pear pie. It was yummy, but I don't think 45 minutes is quite enough cooking time. My pie came out really soupy and the pears were still hard. It was tasty enough that I'm going to try it again...I'll just extend the cooking time a bit next time.


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Let's understand President Barack Obama's strategy in the fiscal cliff negotiations. It has nothing to do with economics or real fiscal reform. This is entirely about politics. It's Phase 2 of the 2012 campaign. The election returned to him to office. The fiscal cliff negotiations are designed to break the Republican opposition and grant him political supremacy, something he thinks he earned with his landslide 2.8-point victory margin on Election Day.
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© 2016 Press of Atlantic City. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Long distance becomes distasteful when other aspects are disturbing
aspiring phoenix
Dear Scarlet(een), I live 1500 miles away from a guy I've been seeing. Without planning it, our travels have brought us to the same cities a couple times in the past few months....
We're Christians; I'm ready for sex but he wants to wait
Binx_mojo asks:I am ready to have sex and my boyfriend is, too, but wants to wait because we are both Christians. Should I wait for him or should I dump him? What should I do?...
Dueling Libidos
I have been with my boyfriend for 3 years now and I am lucky if we have sex once every week or once every 2 weeks. A healthy sex life means a lot to me, I would rather every day or every couple of days, but when I ask him for sex he is tired, he uses the excuse that he works shifts and we have a baby. Well, she is my baby too, but I always have the time and energy for sex....
How do I get my girlfriend comfortable with the idea of a threesome?
Me and my GF have been going out for about a year and I want to get her comfortable with us bringing in another girl, but I don't know how to approach her about it. I don't know what I should say to get her comfortable. I don't want to sound as if I want another girl, I just want to try something new....
Can people with no sexual experience have an STD?
If both the people involved in having sex have had no previous partners of any sexual nature, is it safe to presume they don't have any STDs?...
What's Age Got to Do With It?
Is your boyfriend or girlfriend more than a couple of years older than you? Here's a scoop on age differences and what to watch out for.
We're newly married, had sex with our best friends and it was awful.
I'm 18 and I recently got married a few weeks ago. Thus far we've been pretty happy and are also expecting our first child. A few days ago we had some friends over: his best guy friend and my best girl friend. I guess curiosity got the best of us all and I ended up making out with the girl... and then one thing led to another, before I knew it my husband was having sex with her!...
What if my boyfriend doesn't listen to me when we have sex?
I have never ever had sex before. My BF is great: he knows me, and he likes having fun. We're both about the same age. If he's energetic, what should I do if he gets out of control? His listening skills aren't that great....
"So why do I harp all day about respect, and write books and blogs about it? Because I want every girl to reach her potential. I want every girl to value herself more than all the bling in the world. I want every girl to be safe and to heal from the bad-dark stuff that happens. I want every girl to discover what one of my teacher's calls your "soul wisdom." In other words, I want you to know the real you and to be all in love with you. I want you to know how to stand by and for you. Then you can spread your yummy amazingness to the world. The world *needs* you to make it. It needs you to blow the lid off this mutha (in your own way, of course)! And it starts with respect on the inside." - Courtney Macavinta, co-author
Two women, two partners, and four folks frustrated with intercourse.
My boyfriend and I have been going out for one year and have been sexually active for some time. Usually we have pretty good sex. But lately I've just been getting upset because I can never orgasm through intercourse. I know that's normal for girls but when I ask him to do other things, he usually doesn't want to....


text:
In this Article
- What other names is Lemon known by?
- What is Lemon?
- How does Lemon work?
- Are there safety concerns?
- Dosing considerations for Lemon.
How does Lemon work?Lemon contains antioxidants called bioflavonoids. Researchers think these bioflavonoids are responsible for the health benefits of lemon.
Are there safety concerns?Lemon is safe in food amounts and may be safe in higher medicinal amounts. The side effects of higher amounts of lemon are not known.
Applying lemon to the skin may increase the chance of sunburn, especially in light-skinned people.
Special Precautions & Warnings:Pregnancy and breast-feeding: Lemon is safe for pregnant and breast-feeding women when used as part of a normal diet. But it's not known whether it's safe to use lemon in larger medicinal amounts during pregnancy or breast-feeding. Stick to food amounts.
Dosing considerations for Lemon.The appropriate dose of lemon for use as treatment depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for lemon. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Women's Health
Find out what women really need.


text:
"The Russ Parr Morning Show" shares sad news about a young woman named Jasmine Grady who died in a fatal car accident. Listen to the audio player to hear her family and friends' request to have Drake sing at her funeral.
Keep Up With The Russ Parr Morning Show … LIKE Him On Facebook!
Also On Black America Web:
This Week's Celebrity Instagrams (6/24-7/1)
25 photos Launch gallery


text:
|Publication number
|Publication type
|Application number
|Publication date
|May 28, 1985
|Filing date
|Sep 5, 1984
|Priority date
|Apr 6, 1984
|Fee status
|Publication number
|Jerry L. Adams, Brian W. Metcalf, Bruce J. Lippert
|Original Assignee
|Merrell Dow Pharmaceuticals Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (2), Referenced by (3), Classifications (5), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a continuation of application Ser. No. 597,786, filed Apr. 6, 1984, which is a continuation of application Ser. No. 540,744, filed Oct. 11, 1983, both now abandoned.
This invention relates to 4-amino-4,5-dihydro-2-thiophenecarboxylic acid, esters thereof, and pharmaceutically acceptable salts thereof, to their use as chemotherapeutic agents, and to the chemical processes and intermediates useful in the preparation thereof.
More specifically, this invention relates to γ-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy. These inhibitors are of the formula ##STR1## inclusive of their individual enantiomers and racemic mixtures thereof, and the pharmaceutically acceptable salts thereof, wherein R is hydrogen or lower alkyl. Preferably, the lower alkyl moiety contain 1-6 carbon atoms.
The preparation of the compounds of this invention may be achieved by the judicial selection of the appropriate starting material followed by th application of standard chemical reactions and techniques analogously known in the art.
The preparation of the desired compounds is preferentially effected by a series of chemical reactions starting with derivatives of cysteine. In one such process, the amine moiety of 1-ethoxycarbonyl-2-mercapto-ethanaminium chloride is converted to its t-butoxycarbonyl derivative by reaction with di-t-butyl dicarbonate and the resulting product is treated with ethylbromoacetate, in situ, to form the desired N-[(1,1-dimethylethoxy)carbonyl]-S-(2-carboethoxyethyl)cysteine ethyl ester derivative. Of course, other N-protecting groups may similarly be employed. The so-prepared cysteine ethyl ester derivative is then subjected to a cyclization reaction using Dieckmann reaction conditions, preferably employing lithium diisopropylamide although others may similarly be utilized. The resulting β-ketoester (i.e., ethyl-4[[(1,1-dimethylethoxy)carbonyl]amino]tetrahydro-3-oxo-2-thiophene carboxylate is sequentially reduced and dehydrated, preferably utilizing sodium borohydride, followed by mesyl chloride and the resulting N-t-butoxycarbonyl-protected 4,5-dihydro-2-thiophene carboxylic acid esters is deprotected according to standard conditions, such as lithium hydroxide hydrolysis, followed by reaction with dry hydrochloric acid gas.
Alternatively, the t-butoxycarbonyl protected cysteine starting material can be silylated (by reaction with chlorotrimethylsilane and bis(trimethylsilyl)acetamide and the resulting product, when cyclized by reaction with freshly prepared lithium tetramethylpiperidine, will form a tetrahydro-2-thiophenecarboxylate bearing a silyl ether and alkyl ether at the 3-position thereof. The silyl ether is then removed by treatment with HF in the presence of tetrabutylammonium fluoride, and the product subjected to chemical reduction, preferably with sodium borohydride, to form the crude 3-hydroxy-N-t-BOC-protected-tetrahydro-2-carboxylate ester. This product may then be subjected to the same dehydration/deprotection reactions previously described to obtain the desired product.
As shown in formula I, the compounds of this invention contain an asymetric carbon atom and thus the products exist in enantiomorphic forms. The preparation of the individually desired enantiomers is effected by utilizing the appropriate isomer of the starting material (e.g., the D- or L-form of the starting cysteine derivative wherein the L-isomer yields the (R) isomer and the D-isomer yields the (S) isomer). In the event discriminating procedures are not utilized, obtention of the desired isomer may be effected according to standard techniques, such as separation of the racemic mixture with optically active acids or by the use of prep columns such as Prep Percol columns.
The following specific examples illustrate the preferred methods of synthesis although such examples are not restrictive of the methodology which can be utilized. Obvious equivalency functioning procedures may be utilized depending upon factors fully appreciated by those skilled in the art.
Trimethylamine 120 ml (0.88 mole) is added dropwise over a 10 minute period to a stirring ice bath cooled solution containing 40.7 g (0.22 mole) of cysteine ethyl ester hydrochloride, 51.0 g (0.227 mole) of di-tert-butyldicarbonate, and 400 ml of dry CH2 Cl2 under a positive argon atmosphere. After an additional 20 minutes the cooling bath is removed and the reaction is stirred at 25� C. for 4 hours. The reaction is then once again cooled with an ice bath and 31 ml (0.264 mole) of ethyl bromoacetate is added and allowed to react for 1 hour at 0� C. and 2 hours at 25� C. After removing the bulk of the solvent at reduced pressure the mixture is transferred to a separatory funnel, diluted with 300 ml of ether, and extracted with 200 ml of water. The organic layer is washed successively with 50 ml water and 50 ml brine and dried over MgSO4. Evaporation of the solvent at reduced pressure affords 75.2 g of a light yellow-orange oil suitable for use in Step B.
To a solution of LDA [prepared by the addition of 9.8 ml of 1.75M n-BuLi (0.017 mole) to a solution of 2.4 ml of diisopropylamine (0.017 mole) and 15 ml of THF at 0� C.] cooled to -70� C. (dry ice/acetone) under a positive stream of argon is added dropwise over a 5 minute period 2.83 g of the unpurified cysteine derivative in 60 ml of THF. After stirring for 1 hour at -70� C. the reaction is allowed to warm slowly to 20� C. at which point the mixture is poured into a separatory funnel containing 100 ml of ether and sufficient 1/2 saturated acidic (HCl) brine to adjust the aqueous layer to pH 3 after equilibration. The organic layer is washed with 1/2 saturated brine, brine and dried over MgSO4. The solvent is removed at reduced pressure to afford 2.21 g of oil which affords 1.07 g (44% from cysteine ethyl ester) of nearly pure β-ketoester following flash chromatography (5 cm column) on silica gel eluting sequentially with 20, 30 and 40% EtOAc in hexane.
To a stirring solution of 5.16 g (0.178 mole) of the racemic β-ketoester in 40 ml of absolute ethanol cooled to -5� to -10� C. (ice/methanol bath) is added 340 mg (0.009 mole) of NaBH4. After 25 minutes 5 ml of acetone is added and stirring and cooling is continued for an additional 20 minutes. The reaction mixture is then shaken in a separatory funnel containing 200 ml of EtOAc and 50 ml of 1/2 saturated brine, washed brine, and dried over MgSO4. The solvent is removed under reduced pressure to afford 5.25 g of the crude alcohol.
To a stirring ice bath cooled solution of the above alcohol, 8.3 ml (0.06 mole) of Et3 N, and 60 ml of CH2 Cl2 under positive argon pressure is added dropwise 2.1 ml (0.027 mole) of MsCl. After stirring for 2.5 hours at 0� C. the reaction which was judged complete by TLC is poured into 200 ml of ether, washed successively with 3�30 ml water and brine, and dried over MgSO4. The unsaturated ester so obtained after removal of the solvent at reduced pressure is dissolved in 60 ml ethanol. To the stirring ice bath cooled solution is added 25 ml of 1N LiOH. After 1 hour at 0� C. the reaction is poured into a separatory funnel containing 150 ml of EtOAc, 70 ml of brine, and 25 ml of 1N HCl and extracted. The separated aqueous layer is re-extracted with 30 ml of fresh EtOAc, and the combined organic layer is washed with 70 ml of brine and dried over MgSo4. The solvent is removed under reduced pressure and the residue purified by flash chromatography (6 cm column) eluting with 30, 38 and 45% EtOAc in hexane containing 1% acetic acid to afford 2.62 g (60% yield) of the crystalline acid, mp. 154�-155� C. A recrystallized (ether/hexane) sample afforded correct combustion analysis. % Calcd: C, 48.96; H, 6.16; N, 5.17; S, 13.07%. % Found: C, 48.85; H, 6.14; N, 5.15; S, 12.99.
An ice bath cooled solution containing 2.60 g (10.6 mMole) of the t-Boc acid in 100 ml of EtOAc is saturated with dry HCl. The cooling bath is then removed and the reaction is allowed to stand for 1 hour under a positive nitrogen atmosphere. The precipitated solid is collected washed successively with EtOAc and ether to afford, after drying in vacuo at 25� C., 1.20 g of a tan powder composed of amino acid hydrochloride and ammonium chloride. The solid is dissolved in water and the pH adjusted to 8-9 with 2N NH4 OH. The solution is then placed on a BioRad AG 50W-X8 ion exchange column (HCl form). The purified amino acid is eluted with 2N NH4 OH and the water removed at reduced pressure (30� C. bath) to afford a tan solid. The solid is transferred to a frit, washed with EtOAc and ether, and dried at high vacuum in a drying pistol (acetone) to afford 556 mg (34% yield) of the analytically pure amino acid. Analysis % Calcd: C, 48.96; H, 6.16; N, 5.71; S, 13.07. % Found: C, 48.85; H, 6.14; N, 5.55; S, 12.99.
Into a dry argon-flushed flask containing 12.5 g (37.3 mmoles) of N-[1,1-dimethylethoxy)carbonyl]-S-2-(carboethoxy ethyl)-D-cysteine ethyl ester is added 28 ml (112 mmoles) of bis(trimethylsilyl)acetamide and 0.5 ml (4 mmoles) of chlorotrimethylsilane. The mixture is heated for 7 hours in a 130� C. oil bath and then bulb-to-bulb distilled under a 50 micron vacuum. The 70�-80� C. distilled material is discarded and the 130�-140� C. distilled material is collected to afford 14.0 g of the desired product.
A 37.5 mmole solution of lithium tetramethylpiperidide (prepared at ice-bath temperature by adding 23.6 ml of 1.58M n-Buli to 7 ml (41 mmole) of 2,2,6,6-tetramethylpiperidine in 50 ml of THF) was added over a 10 minute period to a stirring solution containing 14.0 g (34.4 mmole) of the silylated substrate of Step A in 190 ml THF which was maintained under a positive argon atmosphere at -65� C. Following the addition, the reaction was held for 30 minutes at -70� C. and allowed to warm slowly (˜1 hr.) to -35� C. at which point the solution was cooled to -60� C. and quenched with 3.5 ml of acetic acid. The reaction mixture was poured into a separatory funnel containing 300 ml of ether, washed successively with 150 ml water, sufficient 0.5N HCl to afford an acidic aqueous phase, and brine, and dried over MgSO4. Removal of the solvent under reduced pressure afforded 12.4 g of an oil which was purified by flash chromotography (eluting successively with 7.5, 10, 20% EtOAc/Hexanes) to afford 7.53 g of product as a colorless oil.
Into a stirring 25� C. solution containing 7.53 g (18.5 mmole) of the silyl ether of Step B and 93 ml of a 1M ethanolic HF solution (prepared by mixing 1 part 48% aqueous HF with 29 parts of absolute ethanol) was added 18.5 ml of a 1M solution of tetrabutylammonium fluoride in THF. After stirring for 40 minutes the solution was cooled with an ice/methanol bath and 520 mg (13.6 mmole) of NaBH4 was added portionwise at such a rate that the internal temperature did not rise above 0� C. Following the addition the reaction was stirred for an additional 30 minutes at which point the remaining hydride reagent was destroyed by the addition of 10 ml of acetone. One ml of acetic acid was added after an additional 10 minutes and the reaction was concentrated to a volume of 50 ml under reduced pressure. The concentrated mixture was poured into a separatory funnel containing 300 ml EtOAc and washed successively with 100 ml of 1/2 saturated brine, 2�30 ml water, and 50 ml brine, and dried over MgSO4. Removal of the solvent at reduced pressure afforded 10.4 g of an oil which was used without purification.
Into an ice cooled stirring solution containing the crude alcohol obtained in Step C, 75 ml of CH2 Cl2, and 10.5 ml (74 mmole) of Et3 N was added 2.9 ml (37 mmole) of mesyl chloride while maintaining the system under a positive argon atmosphere. The reaction was stirred an additional 5 minutes at 0� C. and then 3 hours at 25� C. The reaction was poured into a separatory funnel containing 200 ml Et2 O and successively washed with 70 ml water, 1N HCl until the aqueous wash tested acidic; 15 ml water and 50 ml brine, and dried over MgSO4. Removal of the solvent at reduced pressure afforded 6.5 g of a brown oil which was purified by flash chromatography (eluting with 15% and then 20% EtOAc/Hexanes) to yield 3.97 g of product. This material exhibited the following optical rotation [α]D amb =+122.8� at a concentration of 0.5M in ethanol. The highest rotation observed for the R enantiomer under similar conditions was -128.1�.
To a stirring ice cooled solution containing 3.7 g (13.5 mmole) of the ethyl ester in 45 ml of ethanol was added 19 ml of 1N LiOH. After stirring for 1 hour the reaction was extracted in a separatory funnel containing 100 ml EtOAc, 40 ml brine, 20 g ice, and 4 ml of 6N HCl. The organic phase was washed with 2�10 ml H2 O and dried over MgSO4. Removal of the solvent under reduced pressure afforded 3.2 g of a crystalline solid, 99% yield. This material was recrystallized from EtOAc/Hexanes to afford 1.2 g of fluffy white crystals. The acid before recrystallization was 99.1% S and 0.9% R.
The recrystallized acid of Step E (1.2 g) was dissolved in 50 ml EtOAc, cooled with an ice bath, and dry HCl gas was bubbled through the solution for 3 minutes. Ten minutes later the cooling bath was removed. After an additional 11/2 hours the reaction was filtered, and the solids washed successively with EtOAc and ether to afford 610 mg of the amino acid hydrochloride as an off white solid.
The sample was purified by ion exchange chromatography (see Step D of Example I) and the aqueous NH4 OH solution concentrated under reduced pressure to a volume of 3 to 4 ml. This solution was cooled to 0� and the crystallized free amino acid collected by filtration washing the solid successively with cold ethanol and ether. The solid is dried in vacuo at 40�-50� C. to afford 325 mg of a white crystalline solid. This sample possessed a m.pt. of 202� C. and the following rotation [α]D amb =+143.7�. Analysis of a sample by HPLC showed it to be 99.8% S enantiomer. Elemental Analysis: Calc. C-41.37; H-4.86; N-9.65; S-22.0. Found. C-41.53; H-4.86; N-9.58; S-22.0.
To a stirring argon-flushed solution containing 31 mg (0.21 mmole) of 4-amino-4,5-dihydro-2-thiophenecarboxylic acid and 0.8 ml of methanol was added 175 μl (1.7 mmole) of thionyl chloride. After 2 hours of stirring at 25� C. the solvent was removed in vacuo to afford the crude amino ester as a hydrochloride salt. The NMR of the above material in D2 O was consistent with the proposed structure.
Other esters embraced by this application may similarly be prepared by reacting the appropriate alcohol with the amino acid according to the foregoing technique.
Illustrative of the pharmaceutically acceptable salts of the compounds of this invention include nontoxic acid addition salts formed with inorganic acids, such as, hydrochloric, hydrobromic, sulfuric and phosphoric acid, and organic acids such as methane sulfonic, salicylic, maleic, malonic, tartaric, citric, and ascorbic acids; and non-toxic salts formed with inorganic or organic bases such as those of alkali metals, for example, sodium, potassium and lithium, alkaline earth metals, for example, calcium and magnesium, light metals of Group III A for example, aluminum; organic amines such as primary, secondary or tertiary amines, for example, cyclohexylamine, ethylamine, pyridine, methylaminoethanol, ethanolamine and piperazine. The salts can be prepared by conventional means.
As stated above, the compound of this invention possess the inherent characteristics of inhibiting γ-aminobutyric acid transaminase which results in an increase in brain levels of γ-aminobutyric acid. Thus, the compounds are useful in the treatment of disorders of the central nervous system, particularly that dealing with the function of involuntary movement generally associated with seisure disorders of epilepsy.
The ability of the compounds of this invention to inhibit γ-aminobutyric acid transaminase and raise brain GABA levels is determined in vitro by the methods of Lippert et al. (Eur. J. Biochem. 71:441, 1977) and in vivo by Jung et al. (J. Neurochem. 28:717, 1977). γ-Aminobutyric acid levels are markedly increased in mouse brains after treatment with compounds of this invention at doses ranging from 0.5 mg/kg to 10 mg/kg of body weight by parenteral or oral routes. This ability is further demonstrated by the protective effect (anti-epileptic), at doses ranging from 0.5 mg/kg to 25 mg/kg, against convulsions elicited by an intravenous dose of 3-mercaptopropionic acid (100 mg) according to the general method described by Sarhan and Seilar, J. Neuroscience Res., 4 (1979) 399-421 which is used to evidence anti-epileptic activity. Therefore, based on the foregoing results, as well as by comparison with other known compounds useful in the treatment of epilepsy the dose range of the compounds of this invention for the treatment of epilepsy is 0.1 mg-25 mg per kilogram of body weight per day, depending upon the age of the patient, severity of the disease state and other factors as determined by the attending diagnostician.
In addition to their use in the treatment of epilepsy, in their effect on the central nervous system the compounds of the invention may also be used in the treatment of schizophrenia, tardive dyskinesia, muscle spasms and, the compounds also exhibit analgesic effects. Standard laboratory methodology, in conjunction with compounds with known chemotherapeutic agents useful for the foregoing, may readily be utilized to determine the optimal doses for each of these indications.
The compounds of this invention can be administered orally or parenterally to animals, particularly warm blooded animals and mammals and humans either alone or in the form of pharmaceutical preparations containing as the active ingredient compounds of this invention to achieve the desired effect. Pharmaceutical preparations containing compounds of this invention and conventional pharmaceutical carriers can be employed in unit dosage forms such as solids, for example, tablets, pills and capsules or liquid solutions, suspensions or elixirs for oral administration or liquid solutions, suspensions and emulsions for parenteral use. The quantity of compounds administered can vary over a wide range to provide from about 0.1 mg/kg to about 300 mg/kg of body weight of the patient per day. Unit doses of these compounds can contain, for example, from about 50 mg to 2000 mg of the compounds and may be administered, for example, from 1 to 4 times daily. Following are illustrative examples of pharmaceutical preparations containing the compounds of this invention:
______________________________________ Per Tablet______________________________________(a) 4-amino-4,5-dihydro-2- 100.0 mg thiophenecarboxylic acid(b) wheat starch 15.0 mg(c) lactose 33.5 mg(d) magnesium stearate 1.5 mg______________________________________
A portion of the wheat starch is used to make a granulated starch paste which together with the remainder of the wheat starch and the lactose is granulated, screened and mixed with the active ingredient (a) and the magnesium stearate. The mixture is compressed into tablets weighing 150 mg each.
An illustrative composition for a parenteral injection is the following wherein the quantities are on a weight to volume basis:
______________________________________ Amount______________________________________(a) 4-amino-4,5-dihydro-2- 100.0 mg thiophenecarboxylic acid(b) sodium chloride q.s(c) water for injection to make 20 ml______________________________________
The composition is prepared by dissolving the active ingredient (a) and sufficient sodium chloride in water for injection to render the solution isotonic. The composition may be dispensed in a single ampule containing 100 mg of the active ingredient for multiple dosage or in 20 ampules for single dosage.
An illustrative composition for hard gelatin capsules is as follows:
______________________________________ Amount______________________________________(a) 4-amino-4,5-dihydro-2- 200.0 mg thiophenecarboxylic acid(b) talc 35.0 mg______________________________________
The composition is prepared by passing the dry powders of (a) and (b) through a fine mesh screen and mixing them well. The powder is then filled into No. 0 hard gelatin capsules at a net fill of 235 mg per capsule.
|Cited Patent
|Filing date
|Publication date
|Jan 14, 1980
|Mar 2, 1982
|Hoffmann-La Roche Inc.
|Novel thiophene derivatives
|Sep 11, 1969
|Mar 25, 1971
|Bayer Ag
|Thiophene derivatives
|Citing Patent
|Filing date
|Publication date
|Oct 8, 1992
|Jun 14, 1994
|Bayer Aktiengesellschaft
|Use of substituted tetrahydrothiophenes, some of which are known, as medicaments, new active substances and processes for their preparation
|Feb 4, 1999
|Jul 3, 2001
|Northwestern University
|GABA and L-glutamic acid analogs for antiseizure treatment
|Apr 18, 1991
|Oct 21, 1992
|Merrell Dow Pharmaceuticals Inc.
|Use of GABA-T inhibitors for the treatment of schizophrenia and phencyclidine intoxication
|U.S. Classification
|514/447, 549/68
|International Classification
|Cooperative Classification
|European Classification
|Aug 22, 1988
|Fee payment
Year of fee payment: 4
|Jul 20, 1992
|Fee payment
Year of fee payment: 8
|Sep 27, 1996
|Fee payment
Year of fee payment: 12


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Ganesh Kunwar
Ganesh Kunwar is a software developer from Kathmandu. He holds a Bachelor's degree in Computer Engineering. Ganesh has more than four years experience in developing web applications using Ruby and Ruby based frameworks like Rails, Sinatra, Middleman, Padrino etc. and is currently the lead Ruby on Rails developer at Jyaasa Technologies. Besides Ruby on Rails, he is also a keen MongoDB enthusiast. He loves ideas. Realizing ideas into reality is his passion.
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Join the 'Calamine' group to help and get support from people like you.
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This place is great! It was very easy to find and the family was very accommodating. The facilities were amazing and very clean. Definitely would recommend and would stay here again.
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recomendable a nuestros amigos
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Very beautiful, cozy apartment with nice hosts. As we arrived, they told us everything we need to know and then left us alone during our stay. So in this apartment you can be for yourself and if you have any questions the friendly hosts are there for you. In the evening they put out the breakfast for the next morning. This was really great, so we got all we need in this B&B for a very good price. We can highly recommend this B&B and next time when I'm in Barcelona, I will go there again. :)
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Peach blossom
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chanceofbooks's Reviews > Heart of Fire
Heart of Fire (Heart Trilogy, #2)
by Kat Martin (Goodreads Author)
by Kat Martin (Goodreads Author)
chanceofbooks's review
bookshelves: 2009-read
Jan 19, 2009
bookshelves: 2009-read
Read in January, 2009
I can recommend Martin's other books, notably Fanning the Flame, however, I just HATED the hero of this one. HATE. The heroine wasn't a whole lot better, but she was plucky and enterprising and entirely wasted on hero. Once a hero needs to resort to aphrodisiacs to woe his lady love, the bloom is off the rose for me :)
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President Barack Obama's recent trip to Israel may, in theory, have shown him to be a supporter of that country (the degree is open to debate), but his statements and lack of policy and actions on issues in the Middle East are increasingly disturbing, even to Democrats.
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Welcome to the Church of Saint Anne
The Church of Saint Anne is a vibrant, active faith community. Along with the many liturgical and sacramental celebrations, there are numerous events, support groups, outreach efforts, religious education and faith sharing activities happening at all times. The Parish office is open seven days a week to serve the needs of parishioners.
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Click here for more information about accessibility at the Church of Saint Anne
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- Families Anonymous 07/28/2016 - 07/28/2016 -
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A fun mini plastic promotional piggy bank that will encourage savings at a young age.
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Add a wow factor to your custom pens and have it inserted in this vibrant full color pen box custom packaging.
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A great measuring promo spoon with 4 different measurements.
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Custom Bird Feeder is made of polypropylene and uses a 2 liter bottle (not included) filled with bird seed.
A brightly colored silicone promotional baster with a clear handle that showcases your imprinted logo.


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Nail Your Novel: Why Writers Abandon Books And How You Can Draft, Fix and Finish With ConfidenceBy bestselling ghostwriter and book doctor with a top London literary consultancy 142 high-starred reviews on Amazon This book is used by award-winning authors and university creative writing departments. 'There are shedloads of books on how to write novels, and a lot of them are longer and considerably less useful' 'I wish I'd had this book a long time ago' 'The author has a proven t...
$12.99Immensely helpful and illuminating to any aspiring writer, this special edition of Stephen King's critically lauded, million-copy bestseller shares the experiences, habits, and convictions that have shaped him and his work."Long live the King" hailed Entertainment Weekly upon publication of Stephen King's On Writing. Part memoir, part master class by one of the bestselling authors of all time,
Make a Scene: Crafting a Powerful Story One Scene at a TimeWrite Scenes that Move Your Story Forward In Make a Scene, author Jordan E. Rosenfeld takes you through the fundamentals of strong scene construction and explains how other essential fiction-writing techniques, such as character, plot, and dramatic tension, must function within the framework of individual scenes in order to provide substance and structure to the overall story. You'll learn how to:
Una guía para leer a Mario Vargas LlosaUna guía para leer a Mario Vargas LlosaUn gigante de la literatura universal y uno de los mejores escritores latinoamericanos de todos los tiempos. Por qué leer a Mario Vargas Llosa, por dónde empezar a leerlo, cómo clasificar el tipo de novelas que escribe, cuáles son los temas recurrentes de sus historias... son algunas de las preguntas que podrás responder con esta guía, además de leer las
$5.99Una carta ficticia para agradecer a un amigo su ayuda en la publicación de una novela de ficción en que se reseña una novela, esta última una trama de suspenso cuya resolución puede explicarlo todo... Juego intelectual, colección de cajas chinas, muñeca rusa literaria, misterio policiaco, El garabato, de 1967, es un experimento artístico arriesgado, producto de una época rica en intentos por
$6.99El lector tendrá por fin con este libro las pautas que necesita para aprender a escribir mejor. El Instituto Cervantes, toda una institución en la materia, da las claves que cualquiera de nosotros necesita para comunicarse de forma efectiva. Elaborado por un equipo de prestigiosos especialistas en la lengua española, está dividido en diversos apartados de índole eminentemente práctica. Éstos
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$14.99Bestselling author Pat Conroy acknowledges the books that have shaped him and celebrates the profound effect reading has had on his life. Pat Conroy, the beloved American storyteller, is a voracious reader. Starting as a childhood passion that bloomed into a life-long companion, reading has been Conroy's portal to the world, both to the farthest corners of the globe and to the deepest chambers of
50 Essential Strategies for Every WriterOne of America's most influential writing teachers offers a toolbox from which writers of all kinds can draw practical inspiration."Writing is a craft you can learn," says Roy Peter Clark. "You need tools, not rules." His book distills decades of experience into 50 tools that will help any writer become more fluent and effective. WRITING TOOLS covers everything from the most basic ("Too...
$11.99With insight humor and practicality Natalie Goldberg inspires writers and would-be writers to take the leap into writing skillfully and creatively. She offers suggestions encouragement and solid advice on many aspects of the writer's craft: on writing from "first thoughts" (keep your hand moving don't cross out just get it on paper) on listening (writing is ninety percent listening; the deeper you


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5 Ways To Be Present and Live in The Now
Half the time, we're so distracted by so many things, we practically let our lives fly past. Sometimes we're just in our head, opening the portal to the doors in the space-time continuum labelled "Past" and "Future". Other times, we're sucked into the Black Hole of the Internet. It's like we can't afford to pay attention to our life anymore, and for some, it takes walking right into a glass door with our head hung over our phone to knock some sense into us. Or not.
So what does being present mean? It's self-explanatory really. It means being present in the present while you work, eat and hang out with people. While it may sound simple but how many times have we rushed our meals while doing something important? How many times do we multi-task per day? And it seems that people spend more time photographing their dinners than talking to the people they go to those dinners with. Here are five practical steps to take control of your life and Be Present:
To read the rest of the post, go to http://ahscribbles.com/the-top-skill-in-your-life/
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Should you Follow Your Passion or Not
The good thing about living in our age is that the internet is filled with career advice. The bad thing about living in our age is that the internet is filled with contradicting career advice.
The economic crisis happened the year I graduated, which meant I didn't have to look far and wide to discover that "Go to school, get into a good university, get a good job and you're set for life" no longer applied. All I had to do was go to work one day and see the empty desks around me. Apparently our peers in the Western world had discovered that a bit earlier but living in the Middle East, someone seemed to have missed the memo.
So at some point in your life, it's 6abee3i jiddan (natural) to type into google, "I hate my job wh…" and google totally gets you. The trick is to somehow find your way through the 264,000,000 results that come up.
Some people will tell you to follow your passion, and again, if you live in the part of the world where you're branded an engineer or a doctor from the day you're born, then there's a high chance your passion is very much different from what you've studied. However, the main risk connected with following your passion is you'll be broke — for a very, very long time — and following your passion — or doing anything in fact — is pretty difficult when you're broke and hungry.
"Following your passion – or doing anything in fact – is pretty difficult when you're broke and hungry." Tweet this
Then Cal Newport entered the scene with his message, "Why 'Following your passion' is bad advice," in his book So Good they Can't Ignore You. His advice focuses on how passion comes after working really, really hard on something, and being really good at it.
Personally, I support the second message, because of a few truths:
- Not everybody knows what their passion is
- The world might not be willing to pay you for your passion
So let's say you're really passionate about counting baby coconuts. The most that someone might pay you for counting coconuts is a free baby coconut drink. But the world might not be ready for your counting-coconut-services, so following your passion happens to be really really really bad advice.
So let's say you're one of those people who doesn't know what their passion is.It's very easy to read all this stuff on the internet and get pretty pumped up about quitting your job and hitchhiking around the globe to discover what your passion is. It's easy theoretically, but pretty hard practically (read $$$$).
But here's one thing to know about those successful 'follow your passion' stories on the internet. To each one, there are probably five failure stories that don't get reported.
So before quitting your job, find out exactly what's bothering you. You might not be having a passion crisis. Ask yourself the following questions:
- Do you get intellectually challenged at your job?
- Are you building your skill set?
- Do you enter a state of flow while you're working?
- Is the world ready to pay you for your services?
If the first three answers are no, then those might be your reasons for 'hating your job' not that you're not passionate about it. Maybe if you find something else in the field that intellectually challenges you then you might throw those 'Malaysia, truly Asia' brochures out the window.
If you do know what your passion is, and really want to make money out of it, then work at monetizing it before you quit your day job. Ask the world if they are ready to pay for it and don't be like that coconut-counter.
The trick is whatever you do, do not make rash emotional decisions based on one bad day at work. Even people who follow their passions will tell you it's not always good in the 'Living My Dream' world. There are difficult clients, and tasks they hate doing but have to do it anyway. And if you're not really convinced, read Cal Newport's "So Good They Can't Ignore You". He definitely does a better job convincing than I do.
Image: Google screenshot and unsplash.com
This post previously appeared on my primary blog; http://ahscribbles.com/follow-your-passion-or-not/
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Unearthing Your Values
So in the previous post, we spoke about defining our personal values so today we're going to delve deeper into the topic. To figure out our personal values we need to answer the cliched question of who we were before the world told us who we should be? And that's not easy. It requires taking a very deep look into our lives, rummaging through the closets in search of any hidden skeletons, opening doors we'd rather pretend they never existed. We'd need to look deep and search for two things in particular; the crossroads and the non-negotiables.
The crossroads
"Two roads diverged in a wood, and I—
I took the one less traveled by,
And that has made all the difference." Robert Frost Tweet this
The crossroads are those life-altering moments where we chose one road instead of another. While there might be many crossroads in our lives-and some might be major mistakes we wish we could undo-there are others that felt right the moment we were taking that first step. Maybe society tried to tell us we were crazy to make the choice we did, and yet we knew deep in our hearts it was the right choice, and eventually things turned out all right. So look at those moments and try to unearth the values driving those decisions.
The non-negotiables
These are the little rules and regulations we've set for ourselves in our work, life, relationships…While some of them might be inherited from society and need to be modified or upgraded, there are some that resonate with our very cores. d regulations. We might not have explicitly written them down, but we have them lying somewhere in the back of our minds.
Maybe they sound something like,
"People come before things."
"Treat others the way you want to be treated."
And most importantly, "Thou shall eat a banana every day of your life."
The non-negotiables usually direct you towards the values you most likely embody, and if they don't – like the banana one – maybe they need to be removed from the list.
Some people might want to do this hunting-for-personal-values with a friend or a family member, and that's actually good as it helps create harmony between friends and family. However a couple of things that need to be noted are:
1) Your personal values must be yours, not theirs. Don't put something on your list just because it's on theirs. Also back every value with a personal story to show it's something you care about.
2) Because it's deeply personal, and it might require you to open up the deepest part of your soul, and be vulnerable with somebody else, don't just trust anybody with this exercise. As Brene Brown advises, "Only share your stories with the people who earned the right to listen to them."
I remember when I first heard that line, it baffled me. I wondered, "How does somebody earn the right to listen to your stories?"
After perusing a lot of Brene's work, I came to realize the answer is simply, "Look at how they react to your not-so-important stories at first. If they react with judgement, sarcasm and apathy, then they probably do not deserve to listen to your deeper stories. The reaction you're looking for from others is usually empathy; someone telling you, I have been in your shoes – or I can imaging being in your shoes – and I totally understand."
Then there are others who might do this exercise alone using the writer's best friend and worse enemy; a blank page. You might start unearthing your values using prompts such as answering the following questions:
- What did you enjoy doing as a child?
- Describe a person you really admire. Why do you admire them? What qualities do they exhibit?
- If you went to Hogwarts, which house would you have found yourself in and why? Alternatively, if you were in the fictional world of Divergent, which faction would you have been in?
Whether you're doing this exercise alone or with a friend, the steps are simple;
- List down your value – e.g. kindness
- Explain why it's important for you –e.g if people were more kind, the world would be a better place so I want to start with myself
- Back it up with experiences from your life that show you embodying the value – e.g. the last time I showed kindness was when I helped that person with something
- Brainstorm ways of exercising the value everyday – e.g. get ideas of doing kindness from websites like randomactsofkindness.org
Feel free to share your personal values in the comments section below. Like this article? Share it with your friends on Facebook
Original post appeared on http://ahscribbles.com/unearthing-your-values/
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3 ways to SWOT-V analyze your life
When it comes to personal development, the main goal is not always to be better than the person next door — though that's not always so bad. The main goal is to become better than we were yesterday, and in order to do that, we need to know where we were yesterday and where we stand today. Conducting a monthly or quarterly SWOT analysis of our life is always a good idea, because whether we decide to change ourselves or not, things change around us.
Isn't it funny how day by day nothing changes, but when you look back, everything is different"-C.S. Lewis Tweet this
In business terms, a SWOT analysis is when we measure our strengths, weaknesses, opportunities and threats. To apply it to our own life, we need to ask the following questions:
1.What are our personal strengths/weaknesses?
It's not always easy to find our own strengths and weaknesses. As humans, we tend to view ourselves differently than how others view us. So it's always best to seek the help of others. Whether it's a therapist, a personal coach, close friends and family, the more people we ask the better. One or two strengths might start appearing more than once and we would need to focus on those.
"Friends are the mirror reflecting the truth of who we are."Tweet this
Tip!: Sometimes people who piss us off the most are the ones who are most honest, so don't discount their answers.
Once we know our personal strengths, we need to brainstorm ideas of how to capitalize on them in order to advance our careers and personal relationships. When it comes to our weaknesses, we can either choose to work on them when they're acting as barriers to our progress or we can choose to work around them and ignore them if they don't hinder us that much. The main idea is to be aware of them and fine-tune our lives to better use our strengths and dampen our weaknesses.
2. What are the opportunities and threats that exist around you?
The opportunities and threats we face deal with our environment; they could be the people around us or the company's hierarchy. Change comes at a price. People around us might not like it. They might start talking about how we've changed and how they don't particularly like the new us. Why? Because stepping out of the comfort zone threatens them somehow. So it's a given that when we start making progress, we might need to shed a few relationships along the way, but that's okay, because every space somebody leaves empty gets filled by someone better.
3. Finally, what does the V in 'SWOT-V' stand for?
The V stands for our personal values that define the important things in our lives. They help us look at the big picture and prioritize every aspect of our live. Possible values could be courage, honesty, loyalty, integrity, family. To know your values you might need to sit with yourself and look at life-altering moments in your life that felt right, and ask yourself, "Why did I make that particular choice?" The undercurrent of an important value may be lying beneath that choice. And another less obvious way of discovering your value is to figure out what makes you angry with passion. For instance, one value that usually inspires a lot of anger is injustice.
So if you're trying to figure out your life right now, take the first steps to SWOT-V analyse your life.
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This post first appeared on http://ahscribbles.com/3-ways-to-swot-v-your-life/
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Photo: "Xhienne — SWOT pt.svg" Wikimedia Commons