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Book your room at The Inch Hotel
Get an overview of this hotel3-star hotel with restaurant and bar/lounge
Situated in Fort Augustus, this hotel is 0.8 mi (1.3 km) from Benedictine Abbey and within 20 mi (32 km) of Urquhart Castle and Original Loch Ness Monster Visitor Centre. Loch Ness 2000 Exhibition Centre and Commando Memorial are also within 25 mi (40 km).
Hotel Features
This hotel features a restaurant, a bar/lounge, and dry cleaning. Free WiFi in public areas and free self parking are also provided. Additionally, laundry facilities, tour/ticket assistance, and wedding services are onsite.
Room Amenities
All 18 rooms offer free WiFi, DVD players, and cable TV. Other amenities available to guests include room service, Egyptian cotton sheets, and coffee makers. Private bathrooms are not ensuite.Would you like to give us feedback? Share it! Opens in a new window
The Inch HotelFort Augustus Fort Augustus Scotland PH32 4BN
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary high-speed wired and wireless Internet access. This Fort Augustus hotel also offers tour/ticket assistance, a garden, and laundry facilities. Complimentary self parking is available on site.
- Bar/lounge
- Breakfast available (surcharge)
- Conference space size (feet) - 30
- Dry cleaning/laundry service
- Free self parking
- Free WiFi
- Free wired high-speed Internet
- Garden
- Laundry facilities
- Luggage storage
- Number of buildings/towers - 1
- Number of floors - 2
- Number of meeting rooms - 1
- Restaurant
- Total number of rooms - 18
- Tours/ticket assistance
- Wedding services
Family Friendly Amenities
- DVD player
- Free Wi-Fi
- Laundry facilities
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi , Free wired high-speed Internet
Free self parking
Room Amenities
- Air conditioning
- Cable TV service
- In-room climate control (air conditioning)
- Coffee/tea maker
- Daily housekeeping
- DVD player
- Egyptian-cotton sheets
- Free WiFi
- Hair dryer
- Iron/ironing board (on request)
- Phone
- Private bathroom (not in room)
- Room service (limited hours)
- Shower only
Where to Eat
The Inch Hotel has a restaurant on site.
Room service (during limited hours) is available.
Hotel Policies
Check-in time starts at 2:30 PM
Check-in time ends at 10 PM
Special check-in instructions:
Check-out time is 11 AM
Payment types
- Pets stay free
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
Pets allowed (no fees)
Optional extras
- Breakfast fee: GBP 15 per person (approximately)
- Crib (infant bed) fee: GBP 35 per stay
Hotel Name
- Inchnacardoch
- Inchnacardoch Fort Augustus
- Inchnacardoch Lodge Hotel
- Inchnacardoch Lodge Hotel Fort Augustus
- Inch Hotel Fort Augustus
- Inch Hotel
- Inch Fort Augustus


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Andrew Walter, Former ASU Quarterback, Wants Kyrsten Sinema's Spot in Congress
Former Arizona State University quarterback Andrew Walter wants to be a congressman.
Walter, a Republican, would have to beat out the rest of the Republican field, then presumably defeat Democratic Congresswoman Kyrsten Sinema to do so.
See also:
-Marc Victor Planning to Run Against Sinema, Expects Help From Ron Paul
Walter's candidacy was first reported by the Arizona Capitol Times, and it's true, according to Walter's filing with the Federal Election Commission.
We don't know what Walter's all about, but we're pretty sure he's not the best ASU quarterback for the job. Of course, we're talking about Rudy Carpenter. Consult the following table we made in Microsoft Paint:
Upcoming Events
Arizona Diamondbacks vs. Atlanta Braves
TicketsMon., Aug. 22, 6:40pm
Arizona Diamondbacks vs. Cincinnati Reds
TicketsFri., Aug. 26, 6:40pm
All You Can Eat Value Pack - Mercury v Wings
TicketsFri., Aug. 26, 7:00pm
Street of NY Family Pack - Mercury v Wings
TicketsFri., Aug. 26, 7:00pm
It looks like the slight edge goes to Carpenter here.
That said, we'll see how serious Walter gets about his run.
Until then, we'll leave you with this:
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss Phoenix New Times' biggest stories.
In Case You Missed It
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Arizona Diamondbacks vs. Washington Nationals
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subset: commoncrawl


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Dallas Charles Barrett
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Jul. 20, 1926, USA
Jun. 18, 2011
Sullivan County
Tennessee, USA
Dallas Charles Barrett, 84, of Kingsport, passed away on Saturday, June 18, 2011, at Holston Valley Medical Center, after a long battle with cancer with his family at his side. His pain and suffering are over and he is home with Jesus and many loved ones.
He was born on July 20th, 1926 in Hawkins County, TN. He was saved at a young age and was well known for his hard work. Dallas retired from Concrete Products, Kingsport.
He was preceded in death by his parents, Edgar and Ida Anderson Barrett; his wife, Mary Kate Barrett; son, Kenny Barrett and three brothers, Oscar, Hugie and Andy Barrett.
Survivors include his two daughters, Rosa Lee Williams & husband, Burl of Church Hill, Janie Gibson & husband, Don of Kingsport, who he had made his home with for 15 years; brother, Junior Barrett and wife, Sue of Johnson City; sister, Gladys Overbay of Kingsport; six grandchildren; several great grandchildren; special friends, Phillip and Betty Wills and a host of friends. He loved to spend time with Phillip, farming and going to auctions.
The family will receive friends from 12:30 pm to 2 pm on Monday, June 20, 2011 at Scott County Funeral Home, Weber City, VA or you may also call anytime at the home of Jane Gibson. Funeral services will be conducted at 2 pm in the chapel with Rev. Raymond Hammonds, officiating. A eulogy will be offered by Junior Barrett.
Burial will follow at Holston View Cemetery, Weber City, VA. Pallbearers will be his family and friends. Honorary pallbearers are Phillip Wills, Junior Barrett, Don Gibson and Burl Williams.
The family would like to extend a special thanks to Amedisys Hospice, Jean, Patti and Misty, W-3, Dr. Shipstone, Dr Ehrenfried and Dr. Reed. Thank you all for you prayers and thoughts during this time, especially, Weber City Church of God.
Family links:
Mary Kate
Barrett (1926 - 1981)
Kenneth Charles Barrett (1948 - 1974)
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Holston View Cemetery
Weber City
Scott County
Virginia, USA
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Record added: Jun 21, 2011
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Fredrick Carter
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The well-known Richards' Theorem of the continuous-time filter theory is reformulated in the digital domain in a convenient manner, leading to a simple derivation of cascaded lattice digital filter structures, realizing lossless bounded transfer functions. The theorem is also extended to the matrix case, leading to a derivation of -input -output cascaded lattice filter structures with lossless building blocks, that realize an arbitrary digital Lossless Bounded Real (LBR) transfer matrix. Extensions to the synthesis of arbitrary, stable transfer matrices in the form of such cascaded lattices is also outlined. The derivation also places in evidence a means of testing the stability of an arbitrary transfer matrix of a discrete-time linear system.


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This page requires a MaxPreps membership account.
Don't stress... It's free and easy to setup.
The Archbishop Alter Knights volleyball team won Tuesday's away conference match against Purcell Marian by a score of 3-0.
Purcell battled in set 1, but Alter's serving and power game were just too tough to PM. Megan Courtney led the team again with 19 kills on 28 attempts, and also contributed 15 assists, a solo block and 9 digs.
(September 27, 2011: Cincinnati, OH 45206) The Archbishop Alter Knights topped the host Purcell Marian Cavaliers volleyball team by a score of 3-0 in Tuesday's league test.
The Knights now have a 11-6 record. They put it on the line next when they host Badin for a Girls Greater Cincinnati - Grey Central test on Thursday, September 29.
The Cavaliers (11-3) will now prepare for their test against Chaminade-Julienne (Dayton, OH). The Eagles enter the Girls Greater Cincinnati - Grey North test with a 11-5 record. In their last test, Chaminade-Julienne was knocked off by Archbishop McNicholas (Cincinnati, OH), 3-1, in a league test.


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Geology Companies serving New Zealand
Current filtering criteriaYou can remove a filter by clicking on the x
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based in Mount Laurel, NEW JERSEY (USA)
With over sixteen years of experience in the market, HSP`s Clean2OTM technology and products served hundreds of commercial and industrial customers worldwide. HSP helped customers not only achieve their cleaning and disinfection goals but also, more importantly meet their business objectives.
Anguil Environmental Systems, Inc.
based in Milwaukee, WISCONSIN (USA)
Anguil Environmental Systems is a global provider of industrial air pollution control, emission abatement and energy recovery systems. We design, manufacturer, service and install thermal and catalytic oxidation technologies as well as heat recovery systems for a variety of applications and industries.Anguil Aqua was developed to help our industrial clients with water ...
Sistema Azud, S.A.
based in Alcantarilla, SPAIN
Azud Group is among the world leaders in filtration, giving solutions to the optimization of the quality of water in industrial, agricultural and urban applications. SISTEMA AZUD is a group of companies made up by more than 20 firms. Sensitive to the problems of water, the main objective of AZUD is the development of technologies and products that allow the efficient use ...
Modern Water - Monitoring Division
based in Cambridge, UNITED KINGDOM
Modern Water's Monitoring division has developed some of the world's most advanced systems for monitoring water quality. We provide market-leading toxicity monitoring systems, trace metal and environmental monitoring systems. The range includes systems for portable, online, and laboratory use. Our toxicity monitoring products, Microtox and Microtox CTM, detect toxins in ...
Pulsar Process Measurement Ltd
based in Worcestershire, UNITED KINGDOM
Pulsar® Process Measurement manufactures and supplies level, open channel flow and pump instrumentation. Our strength is in ultrasonic level measurement. This is a non-contacting technology that is used in a wide variety of industries and applications worldwide. Pulsar Process Measurement has been in existence since 1997, rising in a relatively short time to become one ...
EarthSoft, Inc
based in Concord, MASSACHUSETTS (USA)
EarthSoft`s EQuIS software manages environmental and geotechnical data and is the world`s most widely used environmental data management system. The EQuIS Data Processor (EDP) and Enterprise EDP are the world`s most widely used EDD tools. Many governments, industrials, and especially consultants and labs use EQuIS and EDP. EQuIS Professional and EQuIS for ArcGIS and ...
Maxxam Analytics
based in Mississauga, ONTARIO (CANADA)
Maxxam is the Canadian market leader in analytical services and solutions to the energy, environmental, food and DNA industries and a member of the Bureau Veritas Group of companies – a world leader in testing, inspection and certification services. We support critical decisions made by our customers through the application of rigorous science and the knowledge and ...
United Industries Group, Inc.
based in Newport Beach, CALIFORNIA (USA)
United Industries Group, Inc. (UIG), located in Lake Forest, California has been an industry leader in innovative design, manufacture and installation of custom storage tanks and related systems for wet and dry industrial applications since 1969. We provide far more than just tanks. We provide storage solutions. Our designs include all types storage tanks – bolted ...
BAP Equipment Ltd.
based in Fredericton, NEW BRUNSWICK (CANADA)
BAP Equipment Ltd is a supplier of Instruments used in the Natural Resource Based Industries which include: Forestry,Geology,Environmental,Surveying, Engineering and Safety.BAP Equipment also manufacture a full line of speciality Field Vest and Bags under the name BAP Field Gear. We do custom manufacturing of sewn products to meet your requirements.
based in Englewood, COLORADO (USA)
IHS is the leading source of information and insight in critical areas that shape today's business landscape – including environmental, health, safety and sustainability (EHS&S). Businesses and governments worldwide rely on IHS software, content and expertise to manage a broad spectrum of critical EHS business challenges, including operational risk, product stewardship, ...
Körting Hannover AG
based in Hannover, GERMANY
The outward appearance of Körting Hannover AG has changed over the years – the pillars of success however have remained: specialisation in a leading trade mark engineering of products and know-how, entrepreneurship and employees with a marked engagement in the company. Team-thinking and discussions with our customers smooth the way to optimum results. Quick decisions ...
BELLMER KUFFERATH Machinery GmbH
based in Düren, GERMANY
BELLMER KUFFERATH Machinery GmbH has become a 100%-subsidiary of Gebr. Bellmer GmbH, originated during the transfer of business operations from the Solid/Liquid Separation division of former Andreas Kufferath GmbH & Co. KG. Andreas Kufferath has been dealing with Solid/Liquid Separation issues for many years and consistently introduced new and innovative products to the ...
DAS Environmental Expert GmbH
based in Dresden, GERMANY
DAS Environmental Expert is a leading environmental technology company that provides sustainable solutions for waste gas treatment and wastewater treatment while minimizing resource usage. The family-owned, mid-sized business with headquarters in Dresden, Germany stands out with two decades of technology and market experience. Our employees worldwide further develop this ...
Shanghai Techase Environment Protection Co., Ltd
based in Shanghai, CHINA
TECHASE, which was invested by Tongji University, is a worldwide leading company in solid-liquid separation of industrial & municipal wastewater. Our featured products are Techase® Multi-plate Screw Press, Vertical Fiber Cloth Media Filter, Elaspress® Super-high Pressure Filter Press, Rotary Disc Filter, Multi-plate Sludge Thickener and TCZB Automatic Polymer Stations, ...


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Find. Book. Pitchup.
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2 bookable sites within 40 miles of Ramsgate
Isle Of Sheppey, Kent, England Show on map
|Bronze two-bedroom holiday home
|6 x
|From £87/€104.18/A$152.93/US$114.25/CA$150.10/CHF113/kr992.02/kr778.18/kr977.53/kr13,810/$1,729.62/$72,500/PEN381.08 per 4 nights
|Silver two-bedroom holiday home (disabled access)
|6 x
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|Gold two-bedroom holiday home (pet-free)
|6 x
|From £131/€156.87/A$230.27/US$172.03/CA$226.02/CHF170.15/kr1,493.73/kr1,171.74/kr1,471.91/kr20,794/$2,604.37/$109,167/PEN573.81 per 4 nights
Ashford, Kent, England Show on map
|Swift sited touring caravan
|4 x
|From £45/€53.89/A$79.10/US$59.09/CA$77.64/CHF58.45/kr513.11/kr402.50/kr505.62/kr7,143/$894.63/$37,500/PEN197.11 per night
|Swift challenger sited touring caravan
|4 x
|From £45/€53.89/A$79.10/US$59.09/CA$77.64/CHF58.45/kr513.11/kr402.50/kr505.62/kr7,143/$894.63/$37,500/PEN197.11 per night
Isle Of Sheppey, Kent, England Show on map
Southminster, Essex, England Show on map
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Last week Motivational speaker and writer Zig Ziglar died at the age of 86. He was best known as a motivational guru but was a prominent evangelical who even served as Vice President of the Southern Baptist Convention. Read more: ChristianityToday.com and a pastor's tribute to Ziglar.
Copyright © 2012 by the author or Christianity Today/Leadership Journal.
Click here for reprint information on Leadership Journal.
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Today in U.S. Naval History - October 3
1921 - USS Olympia sails for France to bring home the Unknown Soldier from World War I
1955 - USS Saipan (CVL-48) begins disaster relief at Tampico, Mexico rescuing people and delivering supplies. Operations ends 10 October.
1962 - Launch of Sigma 7 (Mercury 8) piloted by CDR Walter M. Schirra, Jr., USN. In a mission lasting nine hours and 13 minutes, he made six orbits at an altitude up to 175.8 statute miles at 17,558 mph. Recovery by USS Kearsarge (CVS-33).
For more information about naval history, visit the Naval History and Heritage Command website at history.navy.mil.
Maritime Today
The Maritime Industry's original and most viewed E-News Service
Norwegian oil firm Det norske said it expected to reach full production at its Alvheim FPSO (floating storage, offloading and producing unit) overnight after a leak,
1861 - During the Civil War, the frigate, USS St. Lawrence, spots a schooner flying English colors and gave chase. Some four hours later, as she is overhauling the schooner,
Standing NATO Mine Countermeasures Group 2 (SNMCMG2) has completed its third deployment into the Black Sea under the command of Captain Ramazan Kesgin, Turkish Navy.
1776 - During the American Revolution, the Continental brig, Reprisal, commanded by Capt. Lambert Wickes, transports the newly appointed commercial and naval agent, William Bingham, to Martinique.
KVH Industries, Inc., (Nasdaq: KVHI), announced today that it is offering Videotel's new safety and training video about the Zika virus free to all mariners worldwide.


text:
Chat with AJ Mass
Welcome to SportsNation! On Thursday morning, AJ Mass will drop by to take your questions and analyze all the latest football news from a fantasy perspective.
Send your questions now and join Mass Thursday at 11 a.m. ET!
Need an in-depth answer to your question? Want your roster or trade offers reviewed? Get a personalized response from an ESPN expert with The Answer Guys. All questions answered within 24 hours, guaranteed. Ask your question
More Fantasy: Fantasy Home Page
Brad Pitt (Hollywood)
Pick 2---Greg Jennings, Sidney Rice, Pierre Thomas, Santonio Holmes or Steve Smith(NYG).
eli (Chi-city)
Hey AJ,so its come down to my play at Flex. I have a choice between, Maurice Morris, Forte, Hines Ward, or Bradshaw. I know what the safe play is but the guy I face in the championship has AP against CHI, Grant/Driver against SEA, and Ochocinco against KC, so I feel I have to take a chance and hope for the best?!? your thoughts are greatly appreciated. enjoy the holidays-
Brad (Lehighton PA)
Merry Christmas? So i need to play waiver wire/free agents for defs for week 16 (and if i make it to champ game, wk 17) - the top matchups open are browns vs raiders, falcons vs bills, pats vs jacksonville, and giants vs carolina. for week 17 its chicago at det and atl at bucs....and maybe titans vs jacksonville. who would u go with for both weeks - thanks
Kristofor (Edmonton, Alberta, Canada)
I'm in a real dilema here. I'm in the Championship game and I don't know who to start. I have Thomas Jones, Jamaal Charles, Brandon Jacobs and Jason Snelling. I'm thinking TJones is a lock. However, Jacobs has a tasty matchup but Bradshaw seems to be taking the goaline carries. Snelling has an even better matchup but I'm still worried about Norwood. HELP!
Justin (Tampa)
Last week J.Harrison paid off do I start him over D. Jackson with C. Bailey shadowing him.
Justin (Minnesota)
hey! who would be a better start this week Jerome Harrison or Beani Wells?
Steve (NFO)
Do i sit Wayne against Revis on Sunday if that means i have to start Floyd or Knox?
AJ Mass (10:57 AM)
Happy 12/24 one and all. Let's make our lists, check them twice. Time to find out which fantasy players are naughty and which are nice. Who's ready for a lump of coal?
sam (ontario)
MERRY CHRISTMAS, MERRY CHRISTMAS!!!!!! AJ, who should i start as a flex, moreno, maroney or bradshaw??? THANKS!!!
AJ Mass (10:59 AM)
Jacobs looks slow, and Bradshaw looks real strong. I think he's the best play. I worry about Maroney losing some work to Taylor this week and Buckhalter is itching to go against his former team.
Blitzen (Behind Rudolph)
Please help! Can start 2, Fred Jackson, Stewart, and Jerome Harrison.
AJ Mass (11:00 AM)
Put me in the camp that Harrison's big game was, is and will forever be a fluke.
Mark (Akron)
Which DST will keep their opponents below 300 yards...EAGLES (vs Den going for a playoff spot) or ATL (vs. Bills w/QB issues)???
AJ Mass (11:00 AM)
Got to go against the Bills. Brohm? No thanks.
Bill (Boston)
My opponent from last week lost 4 points from a scoring change that gave me a 158.8 to 158.3 victory. Where can I find a summary of scoring changes?Also, in ppr Benson, LT2, Reg Bush, or Fausset (esp w JJ injury)
AJ Mass (11:03 AM)
I'm going with Tomlinson. LJ going to get some carries vs KC and Bush's injury last week puts me off him entirely. As for the Warner scoring change... there were several articles devoted to this on the site.
AJ Mass (11:04 AM)
http://espn.go.com/blog/nfcwest/post/_/id/11584/nfl-takes-away-warner-td-pass Here's one link.
dave (home)
hey aj,playing for a championship this week who do you like better here are my choices fred davis,mason or meachem? we can play two TE's your thoughts?
AJ Mass (11:05 AM)
I like Mason this week. Meachem is too hit or miss, especially with Lance Moore back and there's no way I go near the Skins offense on principle.
Justin (Ohio)
Championship week for me. Couple of dilema's. Would you go with Braylon Edwards or Pierre Garcon? And secondly, Miami or Tennesse's D?
AJ Mass (11:06 AM)
I don't think Garcon plays this weekend. That hand injury needs rest. As for defense... I'm going with Miami and hoping they keep Schaub in check.
Nick (Michigan)
Need # 3 receiver do I start Cotchery, Britt, or Morgan?
AJ Mass (11:07 AM)
Britt. Gage's return may eat into some of his targets, but he's the only one who can legitimately get open downfield on Tennessee.
Rick (Pittsburgh)
Do you like MegaTron, MoMo, or Nicks at flex this week?
AJ Mass (11:08 AM)
Nicks - if he's healthy, which is in doubt. If he can't go, I lean to Mega.
Gabe (New Jersey)
AJ, I absolutely love your Blog - "mass confusion". You are a highly entertaining writer - and not just sports related.Moreno, Rice, LDT, and Charles. I have to sit one of them. Also Driver or Colston (afraid he may not play the 2nd half)?
AJ Mass (11:10 AM)
Flattery may not get you everywhere, but in Gabe's case, it worked. Thanks. I'd sit Charles this week - I really despise the matchup with the Bengals. I go with Colston even in one half - I think Driver is just as likely to get an early seat.
Yukon Cornelius (Arctic Circle)
My tip to you - watch out for the Abominable Snowman! Now I need a tip from you - Meachem or Morgan this week? Merry Christmas!
AJ Mass (11:11 AM)
Meachem?(Lick, lick) NOTHING!
Jerry Peppercorn (Philly)
#3 WR reprise: Avant, Royal, Berrian, Collie?
AJ Mass (11:11 AM)
Collie for me, for the similar reasons I don't like Garcon plus Revis will be all over Wayne.
Dave (NYC)
Start a banged-up Hines Ward or a Dwayne Bowe that got 10 targets last week?
AJ Mass (11:12 AM)
Bowe. The targets aren't going to lessen there, and Ward, though he'll play won't be at top ability.
Jeff (Work)
Pick 2 Rice, Stewart, Charles, MBII?
AJ Mass (11:13 AM)
You have them in the right order.
Mike (Buffalo)
Pick 2... Championship PPR... Deshaun BMarsh or Gates... Thanks.. Happy Holidays!!
AJ Mass (11:14 AM)
I'll sit Antonio.
Scott (ATL)
Hi AJ, got a tough one for you. In the Championship game and need three from T Jones, Mendy, Beanie, Charles, Snelling, and Harrison? Also, should I play Alex Smith over Peyton this week? Thanks.
AJ Mass (11:16 AM)
If you can live with the decision to sit Peyton for Smith then I do it. You can't second-guess yourself though - you're doing it based on your belief that Peyton sits early and Smith goes off on Detroit - it's not an outlandish call... but you have to be prepared for it to blow up in your face. I go with Snelling, TJ and Mendenhall.
Jessica (Florida)
Gimme 4-5 less obvious WRs you'd start over Wayne this weekend?
AJ Mass (11:18 AM)
Devin Thomas, Torry Holt, Davone Bess, Austin Collie.
Bob (NC)
Earlier you went with LDT over Benson? You really think LJ will get that many carries. I cant see how Benson doesnt go for at least 100 yds plus a TD vs terrible KC def.
AJ Mass (11:19 AM)
I just think with the hope of a first-round bye gone for Cincy, they look to resting Benson some for the playoffs - especially against an easy foe, one who LJ REALLY wants to show-of against.
Bill (NY)
What are your thoughts on how to handle a situation with players already came off waivers a day before the Warner stat change went through? Obviously the team out of the playoffs didn't put in any claims.
AJ Mass (11:21 AM)
In poker, there's a term called "significant subsequent action" which nutshelled means that you can't go back and change an error once it's been "accepted" if it's discovered too late. From a scoring standpoint, the change in result is not "too late" to fix, since the next week's lineups have not locked. For waiver moves, once they've been assigned, that's significant enough of an action to prevent changing them now.
J.B. (Dunmore, PA)
If Charlie Frye plays, would Louis Murphy be worth starting Sunday or doesn't it matter?
AJ Mass (11:22 AM)
I don't think it matters. Murphy is not a good play regardless of which of the four QBs possible goes.
Brian (San Diego)
Where there score adjustments made last night? Do you know who? Last week I had lost by a point, then all of a sudden I'm in the Chanmpionship! Freaking great, but I can't figure out why and what changed.
AJ Mass (11:24 AM)
The biggest scoring change was the NFL ruling that Kurt Warner's "pass" to Anquan Boldin was a "lateral" meaning it is officially a running play. Passing yards and the touchdown points for Warner are deducted. If it was something else, I'm not sure what it was.
Donald Driver (GB)
You said earlier that I may take an early seat? Isn't my team fighting for a playoff spot? Please elaborate
AJ Mass (11:25 AM)
Seattle isn't the toughest opponent, and you could be up big early... plus if the scoreboard from the Meadowlands reads Panthers up 21 late, then your only "competition" for the playoffs is essentially out as well.
Adam (MI)
All I want for christmas is an answer from AJ! Im really weary of Revis island, do I roll with Harvin over him? And pick one RB.. Harrison, Charles, or MBIII
AJ Mass (11:27 AM)
Assuming this Q is Wayne or Harvin, I would go Wayne. I'm not sold on Harvin's headaches being gone. For RB, I would go with Charles - a slight edge over triple-sticks.
Marsh (St. Louis)
If Fargas doesn't go, do I start M.Bush, Wayne, or Collie at flex?
AJ Mass (11:29 AM)
I'd go with Collie. I don't trust Cable to go with Bush over McFadden.
Jim (Atlanta)
Am I crazy to think about starting J. Cribbs at WR? He may play some RB and the Oakland run defense is awful. My other options are Megatron, Josh Morgan, A. Bryant.
AJ Mass (11:30 AM)
I'd go with Morgan. Bryant's still too fragile, and Cribbs doesn't have any real value in my eyes other than the returns. Next season, with a real coach, perhaps the Browns use him better.
Dan (MI)
Need help picking one RB: S. Jackson, T. Jones, or Maroney? Thanks.
AJ Mass (11:31 AM)
TJ for me. Jets should get yards, and I'm just waiting for that other shoe to drop with S-Jax's back.
K (philly)
What do you make of this audible nonsense with favre? Doubt it affects my decision to start Donovan over him but just curious about your thoughts
AJ Mass (11:33 AM)
Like you said - nonsense. If Childress really had a problem with it, he'd bench him - period... which he wouldn't do b/c Tarvaris is not the answer. So, it basically is a moot point.
Santa (The North Pole)
Before I get on my way to deliver the presents I need to set my lineup for the weekend. Do you go with the Pack or Cards D/ST?
AJ Mass (11:35 AM)
The way Mr. Hasselbeck has been handing out "gifts" at a quantity that has YOU jealous... I go GB.
jim (houston)
no question just bragging drafted chris johnson in the 13th rd last yr cost me a 1oth rd this year get him as a 7th rd next year.
AJ Mass (11:35 AM)
Big ego? Tsk, tsk. NAUGHTY LIST for Jim.
j. smith (charlotte)
warner or romo?
AJ Mass (11:36 AM)
I think Romo. Washington is completely lost on both sides of the ball.
Mark (KC)
Rice vs Pit, Harrison vs. Oak, Wells vs Rams. Pick 1 please.
AJ Mass (11:37 AM)
I like Rice. He's going to get 6-8 receptions against that soft passing defense.
Brett (Tallahassee)
You have some mad love for Snelling....would you rank him over say Ryan Grant this weekend?
AJ Mass (11:38 AM)
I would. Buffalo's run D is awful, and Turner is way too fragile to play.
Rick (Omaha)
You mentioned that Cincy might be out of a bye, if SD wins tomorrow, how do you think that affects Palmer... I know, not the best option, but the rest of my team is stacked, which is why I am in the finals...
AJ Mass (11:40 AM)
They are out of a bye. Best they can do is tie SD at 11 wins and they lost to them H2H. I don't think it affects Palmer though. He is who he is.
Bill (LSU)
Better matchup for D/ST: Cards or 9ers?
AJ Mass (11:41 AM)
I'd play the 49ers. It's a toss-up as to which matchup is better, but the way SF is hitting lately, I don't envy those Lions.
Doug (New York)
AJ Mass (11:43 AM)
We may play FANTASY Doug, but the stats have to come from REALITY. A lateral is not a forward pass, and does not count as passing yards. End of story.
Sean (Ravena NY)
Playing "cute" in the finals could be dangerous. Would you really start Devin Thomas over Reggie Wayne ?
AJ Mass (11:44 AM)
No, I wouldn't... but the question asked for some "lesser" names that I think might perform better. I provided them... what you do with that info is up to you.
AJ Mass (11:46 AM)
Time for some speed... Lightning Round commencing in 5,4,3...
Frank (Beans)
Thomas Jones or J. Harrison??
AJ Mass (11:46 AM)
Jones for me.
TC (Dundee IL)
Gates or Findley? Barber II or Snelling?
AJ Mass (11:46 AM)
Finley, Snellong.
Beth (South Dakota)
Benson (w LJ interference) or SJAX w back probs?
AJ Mass (11:46 AM)
Benson by a nose. Still think he gets good stats...
Adam (DC)
MSW or Holmes?
AJ Mass (11:47 AM)
devin (cape canaveral)
morgan or ward
AJ Mass (11:47 AM)
Brian (FL)
Hartley or Akers
AJ Mass (11:47 AM)
Flip a coin.
Jim (NJ)
Bowe or Britt?
AJ Mass (11:47 AM)
john (ma)
AJ Mass (11:47 AM)
I like Crabtree this week.
Paul (Norwalk, CT)
Knowshon Moreno or Brian Westbrook? Calvin Johnson or Michael Crabtree??
AJ Mass (11:48 AM)
Moreno and the Crab. Westbrook gets 5 touches tops.
Pete (North Pole)
P. Manning or Roethlisberger?
AJ Mass (11:48 AM)
Rick (Omaha)
Palmer or Cambel
AJ Mass (11:48 AM)
Brian (Chicago)
Heath Miller or Celek?
AJ Mass (11:49 AM)
Keith (MD)
Mendenhall or P Thomas
AJ Mass (11:49 AM)
Rashard for me.
Paul (Chicago)
J Harrison or S-Jax?
AJ Mass (11:50 AM)
S-Jax. Not a believer in Jerome.
Joe (Baton Rouge)
Where do you have Stewart ranked if DAW is out?
AJ Mass (11:50 AM)
Top 5.
Big-R (Cali)
Farve or Rivers Mendy or Stewart
AJ Mass (11:51 AM)
Rivers, and Daily Show.
TONY T (Hoboken)
AJ Mass (11:51 AM)
Mostly anyone vs Forte.
Ron (Clarks Summit, PA)
I hope Santa comes to Villa Allegre tonight! I had 72.1 points worth of Jerome Harrison and Jonathan Stewart on my bench last week, but managed to advance to the finals. Which one would you promote to my starting lineup for the championship game, and who would sit among my usual lineup of ADP, MJD, VJax, Ocho, and Driver (RB, RB, WR, WR, flex)?
AJ Mass (11:52 AM)
No way I move Harrison, but I would start Stewart over Ocho for flex.
mike (NC)
marshall or austin
AJ Mass (11:52 AM)
Rick (Omaha)
Do I win my league Championship?
AJ Mass (11:53 AM)
If you score more points, yes. Otherwise, no.
Forsett or Sproles?
AJ Mass (11:53 AM)
Mardis (chicago)
Mike Bush or bradshaw
AJ Mass (11:53 AM)
K (philly)
Arizona, Cincy, or Minny D? make my day and answer a second question!
AJ Mass (11:54 AM)
Snow Miser (North Pole)
TE: Fred Davis or Shiancoe?
AJ Mass (11:54 AM)
Fred... he's about the only thing working in that Skins offense.
Adrian (Iowa)
roddy or smith (car)
AJ Mass (11:55 AM)
White. He'll be running at a different speed with no Revis on him this week.
Steve (Detroit)
Mendy or Maroney?
AJ Mass (11:56 AM)
Mendenhall... I do not like the NE RB sitch this week... too murky.
J.B. (Dunmore, PA)
Flex time: Ganther or MSW?
AJ Mass (11:56 AM)
Bob (Chicago)
Pick 2: Fred Jax, J Charles, D Bowe, or Jacobs
AJ Mass (11:57 AM)
Fred and Dwayne.
Mike (Boston)
More flex time: Bowe or Charles
AJ Mass (11:57 AM)
AJ Mass (11:57 AM)
AJ Mass (11:57 AM)
AJ Mass (11:57 AM)
AJ Mass (11:58 AM)
And with that answer, we'll put a bow on this chat. Thanks to all who took part, and a happy merry and merry happy to one and all.
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The woman is so spontangily. I would like to date her, I can almost see, taste, hear, smell and feel her yet she is so far away.
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Controversy Surrounds Sept. 11 Memorial
In New York City, a spirited dialogue is raging over what will be built on the 16 acres once occupied by the World Trade Center before the deadly terror attacks of Sept. 11, 2001. Recently, eight finalists in the competition for a 4.5 acre memorial within the site were released. But the agency overseeing redevelopment of the land acknowledges that negotiations over what will actually be constructed there are far from over. Allison Keyes reports.
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Veteran honored in Eldred
Members of the Tusten-Highland VFW Post 6427 joined together on June 11 at the Eldred Senior Center to honor, Paul G. Zimmermann, who was considered a community leader. Read more
Montoza Cemetery plot owners annual meeting
Interested plot owners requested to attend at the town hall, 7pm.
Summer teen program
First day for ages 14+ at Sunshine Hall Free Library, 4-6pm, Fri. 845/557-6258.
Summer reading program
First day of "One World, Many Stories" for grades 1-5 at Sunshine Hall Free Library, 4-5:30pm, Thurs. 845/557-6258.
Diggin' the plants in Eldred
Lou Monteleone has created the Corner Community Garden in Eldred because he says he would like there to be a peaceful place where people can socialize. Monteleone is the president of Eldred's Lion's Club, and he owns the land on which the garden is located. He says the idea of the garden originated from a community garden in Liberty. Read more
Book sale
Sunshine Hall Free Library books for sale at Highland town hall, 10am-4pm. 845/557-6258.
Scholarship dinner
Professional Women of Sullivan County's annual dinner at Eldred Preserve, 6pm, $25. RSVP: 845/798-3332.
World Trade Center artifact heads for Highland
A 380-pound piece of steel from the World Trade Center (WTC) is making its way from New York City to the Town of Highland. The artifact will be used to establish a WTC Memorial honoring all emergency service providers. Town of Highland Supervisor Andrew Boyar made the announcement at the town meeting in Eldred on May 10. Read more
Prom talk: a sobering yet empowering message
High school proms typically result in the kind of memories that last a lifetime. The Sullivan County Sheriff's Office and Eldred Central School District (ECS) wanted to increase the likelihood that those memories will be good ones, and that those lifetimes won't be shortened by bad decisions. Read more
Bake sale
Cookies, cakes, muffins, breads, pies & brownies; even baked treats for dogs at the Eldred firehouse, 8am-12noon. Hosted by Yulan Fire Dept. Ladies Aux.


text:
Fast Start for Mission Impazible
The 9-year-old son of Unbridled's Song sits atop the first-crop sire list and already has a stakes winner in Tremont Stakes victor Silver Mission.
The 9-year-old son of Unbridled's Song sits atop the first-crop sire list and already has a stakes winner in Tremont Stakes victor Silver Mission.
Silver Mission takes the Tremont Stakes by six lengths.
Once upon a time, not long ago (actually, only three months ago), Twin Creeks Racing Stables had a hot prospect for the Kentucky Derby named Destin.
A Harlan's Holiday colt breezed an eighth of a mile in :10 and a colt from the first crop of Mission Impazible worked a quarter-mile in :21 3/5 to top the May 18 under tack show workouts for the Fasig-Tipton Midlantic sale of 2-year-olds in training.
Sequel Stallions New York's Mission Impazible is off to a winning start as a sire.
Gallant Stable's grade I winner Majestic Harbor will go for his second consecutive graded stakes victory of the Fair Grounds Race Course & Slots meet in the $400,000 New Orleans Handicap (gr. II) Mar. 26.
The Feb. 29 under tack workouts for the March 2 Fasig-Tipton Florida sale of 2-year-olds in training resulted in 10 horses tying for the fastest time of :10 at the popular distance of an eighth of a mile.
Freud, this year's second-leading sire in New York who topped the list in 2014, will stand for $10,000 in 2016 at Sequel Stallions New York near Hudson.
The two-session Fasig-Tipton sale of New York-breds Aug. 15-16 in Saratoga Springs, N.Y., figures to be strong off the recent history of the sale and the demand seen so far this year in the open yearling market.
Call Me George wore down Albano and favorite Moreno late in the $400,000 New Orleans Handicap (gr. II), engineering a 22-1 upset that provided jockey James Graham a milestone win March 28 at Fair Grounds
Moreno is scheduled for his first start in the Pelican State Saturday, in the $400,000 New Orleans Handicap (gr. II) at Fair Grounds Race Course & Slots.
Moreno, a homebred grade I winner for Southern Equine Stable, will head to Fair Grounds for the New Orleans Handicap (gr. II) March 28, trainer Eric Guillot said.
Lenny Shulman talks with Randy Gullatt of Twin Creeks Farm about Constitution, Mission Impazible, Graydar, Dubai, & business partner Steve Davison. Lenny also touches on TVG and the NTRA. Presented by Hill 'n' Dale Stallions watch video
Sequel Stallions New York near Hudson, N. Y., has released its 2015 stallion roster and fees, with Freud leading the list at $10,000, unchanged from 2014.
The first session of the reformatted Fasig-Tipton Saratoga fall sale Oct. 6 saw a Curlin filly and an Elusive Quality mare sell for the highest price of $60,000.
Grade II winner Birdrun has been retired from racing to stand at Robin Murphy's Poplar Creek Horse Farm near Bethel, Ohio. His fee is $2,000.
Dogwood Stable's Palace Malice may have been the narrow second choice in the New Orleans Handicap (gr. II) at Fair Grounds, but the son of Curlin proved best in an impressive 4 3/4-length score going 1 1/8 miles.
Classic winner Palace Malice will try to keep his fast start to the 2014 season going when he faces an accomplished field as the highweight in the New Orleans Handicap (gr. II) March 29 at Fair Grounds.
Dogwood Stable's 2013 Belmont Stakes (gr. I) winner Palace Malice will shoot for his second win of the season in the $400,000 New Orleans Handicap (gr. II) March 29 at Fair Grounds Race Course & Slots.
Owner Rick Porter has picked out a couple of stakes options for Normandy Invasion following the colt's record-breaking return to action in allowance company Feb. 22 at Gulfstream Park.
Last year's Belmont Stakes (gr. I) winner Palace Malice will launch his 2014 campaign in the $250,000 Gulfstream Park Handicap (gr. II) March 8 at Gulfstream Park, according to Dogwood Stable president Cot Campbell.
Multiple grade II winner Mission Impazible was represented by his first reported foal when a filly was born Jan. 20 at Hidden Lake Farm in Otisville, N.Y.
Dogwood Stable's classic winner Palace Malice is in Aiken, S.C., to be prepared for a 2014 campaign that will likely start in the $400,000 New Orleans Handicap (gr. II) at Fair Grounds Race Course & Slots.
Grade I winner Graydar will ship to Saratoga Race Course the morning of July 13 to rejoin trainer Todd Pletcher after three months on the sidelines, Twin Creeks Racing announced.
Two years after winning the Belmont Stakes, George and Lori Hall's Ruler On Ice will again travel the full circuit of the Belmont Park main track oval June 7 when he starts in the 1 1/2-mile Brooklyn Handicap.
|Breeder / Owner
|Albert M. Stall, Jr.
|William I. Mott
|Country Flavor
|Greg Geier
|Paul J. McGee
|El Caballo
|Ralph E. Nicks
|Fast Alex
|Greg Geier
|Mission Impazible
|Todd A. Pletcher
|Prairie Gold Lassie S.
|Iowa Registered and Foaled Three Year Old Colt and Gelding Route H.
|John Morrissey S.
|California Thoroughbred Breeders' Association S.
|Prairie Gold Juvenile S.


text:
Engine Mechanical problem
2001 Chevy Metro 4 cyl Front Wheel Drive Automatic 194000 miles
the crankshaft pulley turns when I try to take off center bolt. Is this the only bolt that needs to come off? How do I take off this pully?
Tuesday, October 12th, 2010 AT 12:12 PM


text:
->'''Tom Ballard''': [about Diana] Your smile is like a crack in the gates of hell. One can smell the sulphur and hear the screams of the damned through your smiles.
Broadcast between 1990 and 1994 on the Creator/{{BBC}}, ''Waiting for God'' was a British sitcom that ran on [=BBC1=] for five series. It, like many Sit Coms of the time was set in an institution of some kind, in this case Bayview Retirement Village, near Bournemouth.
The main character is the ever cynical retired photojournalist Diana Trent, who spent her working life documenting the most momentous and dangerous events of the times. The story mostly focuses on her relationship with Tom Ballard, a retired accountant who is rapidly losing his marbles, although to what extent he plays it up is unclear. Diana is at Bayview because a life of action and adventure has left her without any family, aside from her niece, and Tom is there because his family wanted rid of him.
Diana's frustration at the prospect of years of being alternately patronised and ignored at Bayview is vented at the management of the retirement home and Tom's ungrateful family, seeking to score moral victories against them at every opportunity while blackmailing the managing directors of Bayview to prevent them throwing her out. Her niece has a much better relationship with her than Tom's family has with him, but the relationship is distant and rather one sided with her niece doing most of the work.
Came thirty-seventh in ''Series/BritainsBestSitcom''.
!!Tropes in ''Waiting For God''
* AllTakeAndNoGive: A good portion of the relationship between Jane and Harvey, professionally and personally, with Harvey being the Taker.
* AmbiguouslyHuman: Harvey, according to Diana.
* AscendedExtra: Basil Makepeace is a prime example of this. He originally started off as a background character with very few lines. His presence is more developed in series 2. It's not until series 3 that he turns into a major character going so far as to help Diana and Tom in their adventures plus becoming a well-established friend of the latter.
* BlackComedy: And '''how'''.
* TheChewToy: No one likes Marian, and seeing her reaction to being outright insulted can be quite entertaining. Because of her personality and the way she treats the other characters, the audience isn't encouraged to sympathize with her. She does have a few sympathetic moments, but her character remains unchanged [[spoiler: even after she gets into the new age ideas.]]
* CloudCuckoolander: Tom, most certainly. He's got his head in the clouds so often that when he makes a genuinely valid point, everyone thinks that is a sign he ''has'' lost his mind.
** There is one time when Tom explains that he's fully aware he's living in a fantasy world. He points out that in the real world he's old, sick, and in constant pain, while in his fantasies he's a dashing, young hero having marvelous adventures.
* ComicallyMissingThePoint: In "The Thief", when the prospect of the cops showing up is brought up, the denizens promptly start talking about which cop they want to show up.
* CoolOldLady: Diana, in ''spades''.
* CorruptCorporateExecutive: Harvey Baines.
* DeadpanSnarker: Diana, and she's ''quite'' good at it, as this exchange from the show's very '''first''' episode makes clear.
-->'''Jane:''' Sometimes I think you ''enjoy'' sniping away at me and the residents.
-->'''Diana:''' No, Jane. I don't. You lot are sitting ducks. You need a ''moving'' target to enjoy it.
* DecemberDecemberRomance: Tom and Diana, who meet each other in their seventies and quite love each other by the series' end.
* DirtyOldMan: Basil Makepeace, who prefers to introduce himself as "Bayview's Resident Stud"
* DirtyOldWoman: Several. When they start to make their moves on Tom, Diana explains that this is all because women simply live longer than men so they have to work harder to find a man at their ages. She then explains that working harder can also mean gouging out the eyes of any hussy who looks at your man. They go back to chasing Basil.
** Harvey's mother definitely counts.
-->'''Mrs Bains:''' It was so dull in there I had to fight down an urge to jump on the table and shout "[[UsefulNotes/BritishEnglish Bum!]]" and then follow it up with a display of the same.
* GettingCrapPastTheRadar: When Tom and Diana finally start a sexual relationship, clues they have been at it include fictional religious references, furniture damage and taking extra sugar in your tea (like, fifty extra sugars in your tea, or on one memorable occasion simply upending the sugar bowl)
* ManicPixieDreamGirl: Tom's son Geoffrey is so boring that he thinks shelving is fascinating, and his wife Marian is so wild that she sleeps with literally anyone, drinks and drugs herself so much that she is almost permanently comatose, and is so selfish she actually wishes death on Tom so that she can get his money.
* MoodWhiplash: The later seasons have a surprising amount of drama, although they are no less hilarious. Many episodes flip multiple times between comedy and seriousness, often in the same scene.
* {{Narcissist}}: Harvey Baines is a textbook case of this as his constant self-worship and efforts to please himself show. The constant threats Harvey's behavior causes for the residents of Bayview are often the main crux of episode plots.
* LoveAtFirstSight: Jane describes how she fell in love with Harvey as this.
* LoveMartyr: Jane thinks of herself as this.
* ObfuscatingStupidity: It is clear that Tom has been doing this for so long that he is BecomingTheMask.
* OddCouple: Diana and Tom. Indeed, Diana explicitly compares the fastidious Tom to [[Theatre/TheOddCouple Felix Unger]] when they move in together.
* ParentalSexualitySquick: Most of the humour relating to Tom and Diana's affair comes from Tom's son and daughter-in-law.
* RunawayBride: Played with. Unhappy with his status of being Diana's 471st lover, Tom piles increasing amounts of pressure on her to accept his marriage proposal. [[spoiler: He then jilts her at the altar, delighting her and achieving a unique status as the only man to do that.]]
* StockholmSyndrome: Jane. She is still smitten for Harvey after being repeatedly abused by him and even told point-blank by him that he hates her.
* VideoInsideFilmOutside: (If you count their veranda as "inside")
* VerySpecialEpisode: Most of the series, actually, but some episodes stand out more than others. There's one where Tom suffers from a blocked urinary tract from an enlarged prostate and is too embarrassed to tell anyone. Cue humorous scenes of Diana thinking Tom is hiding an affair ending up in a true emergency followed by the long speech from Diana scolding Tom for not letting anyone know he was ill (addressed to the audience really). Other episodes deal with Diana seriously wanting to commit suicide when she is convinced she has cancer and another where Diana does not take her Diabetes seriously and ends up terribly ill.
* WellDoneSonGuy: Diana's niece has her moments, when someone needs tearing into.
-->'''Diana:''' Of course, I would have broken her leg too.
* WeWantOurJerkBack: Diana finally drives the odious Bayview manager Harvey Baines into an asylum [[spoiler:or so everyone thought; he was just faking it]] and while everyone hates Harvey, they are still mad at her for doing it but that part's more the next trope.
* WhatTheHellHero: The aforementioned arc in which Diana manages to drive Harvey Baines mad.
* WhereTheresAWillTheresAStickyNote: When Tom has surgery, his greedy daughter-in-law insists that everything in his and Diana's apartment be labeled so Diana can't claim anything of his.
* YoungerThanTheyLook: Stephanie Cole, who plays Diana, is well-known for playing characters who are a good deal older than she is. She's actually about 20 years younger than Diana is supposed to be.
* YourMom: From Jane to Harvey, in Korean: "Your mother slept with a tiger!" [[spoiler:It's a Korean proverb.]]


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text:
|Property type
|Minimum Stay
|7 nights
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Settignano Estate is comprised of three elegant, air conditioned country homes situated within walking distance from the village of Settignano and only six kilometers from the center of Florence. These homes provide an ideal base for visitors who seek to experience the best of both city and country life. The idyllic grounds (3.70 acres) are surrounded by olive and fruit trees and offer stunning views over Florence. In addition, a new (shared) pool has recently been completed. The Estate's three units sleep two, four, and six guests, and rented together can accommodate up to 12 people. This makes it a perfect venue for a large group consisting of family or friends to experience the splendor and comfort of Tuscan hospitality.
Settignano is a picturesque borgo located on a hillside northeast of Florence, offering spectacular views of the vibrant city below. Its name is famous as it gave birth to three of the principle sculptors of the Florentine Renaissance: Desiderio da Settignano, Bernardo, and Antonio Rossellino. The young Michelangelo lived here as well in a nearby farmhouse.
The gated property is accessed by a paved road. Each separate unit has an independent entrance. Unit One is shared with the owner, a well-known interior designer who speaks fluent English and French and will be happy to help her guests during their stay. The houses lay in a classical Tuscan setting and were once used to store young lemon tree saplings during winter months and olives during fall crop. The are now converted into comfortable country homes where you can find a perfect balance between modern and traditional amenities and furnishings. The property is landscaped with flowers and herbs; the green garden is loved and looked after by a caretaker and provides fresh vegetables that are used in the kitchen. Each unit offers lovely outdoor spaces to relax or dine al fresco.
The very well-behaved dog belonging to the owner lives on the property.
Included in the rental price: Daily maid service (except Sunday), linen/towel change twice weekly, heating, final cleaning, Internet connection, air conditioning, simple welcome dinner and grocery shopping
Services available upon request (at additional cost): Chef service, extra maid, laundry
Unit Three sleeps six guests and is about 1500 sq. feet. Access to the house is possible from all the rooms located both on the ground and on the first floor since the three suites have French windows leading to the private garden. On the first floor is a spacious living room with TV, sofa, and fireplace. The fully equipped kitchen (stove, oven, fridge, dishwasher, utensils) and dining area overlook a comfortable, outside sitting area with a table for al fresco dining. The first bedroom consists of a four-poster queen bed, fireplace, walk-in closet, en suite bathroom with bathtub, and views of Florence. On the ground floor (down 14 steps) are the other two bedrooms, the first offering a king bed, walk-in closet, and en suite bathroom with bathtub and large shower. The third bedroom has a queen bed, safe box, walk-in closet, and en suite bathroom with a large shower. Next door is a small laundry room with washing machine.
Additional amenities include central heating, AC, satellite TV, wireless high speed Internet access, outside furnishings, and a mobile phone with rechargeable card.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jul 21, 1992
|Filing date
|Oct 5, 1990
|Priority date
|Oct 5, 1990
|Fee status
|Also published as
|Publication number
|Bernard Dugas, Catherine Druez, Pierre Braquet, Jean M. Mencia-Huerta, Catherine Uyttenhove, Jean-Christophe Renauld, Jacques Van Snick
|Original Assignee
|Ludwig Institute For Cancer Research, Departemente D'immunologie Institut Henri Beaufour
|Export Citation
|BiBTeX, EndNote, RefMan
|Non-Patent Citations (24), Referenced by (22), Classifications (30), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates to modulation of antibody responses in animals, including humans. More particularly, it relates to the stimulation of IgG production and the suppression of IgE production via manipulation of a mechanism related to both of these.
The role of cytokines in immunological processes has now been recognized to be important and complex. A recent review article by Whicher et al., Clin. Chem. 36(7): 1269-1281 (1990), the disclosure of which is incorporated by reference herein, nicely summarizes what is known about the various cytokines and growth factors, including interleukins 1 through 8. Sources for these molecules, as well as their target cells are described. Of particular relevance to this disclosure are interleukin 4 ("IL-4" hereafter), and a cytokine not discussed in the review article, but know to the art, interleukin-9 ("IL-9" hereafter).
IL-4 is derived from T cells and mast cells, and targets T cells, B cells, macrophages/monocytes and mast cells. In particular, as Whicher points out at page 1274, IL-4 has a major role in the allergic response, following its release by activator TH2 cells. The IL-4 molecule is involved in "Ig switching", i.e., the change to production of different types of Ig by B cells. This cytokine influences a switch toward production of IgE and IgA. See Yokota et al., Immunol. Rev. 102: 137-187 (1988).
IL-4's involvement in the allergic response is discussed in some detail by Knight, Bio/Technology 8: 717-719 (1990), the disclosure of which is incorporated by reference. The reference discusses, inter alia, the possibility of "short-circuiting" the allergic response by administering a soluble receptor of IL-4 to an afflicted subject. Both natural and recombinant forms of the receptor are available, but the latter type cannot bind to cells because it lacks a portion of the complete molecule Nonetheless, it binds to the IL-4 molecule, preventing the stimulus leading to Ig switching in B cells.
This approach, i.e., that of using a soluble receptor for a cytokine so as to impact its normal effect, is demonstrated in the scientific literature. Fanslow, et al., Science 248: 739-741 (May 11, 1990) discuss the use of soluble IL-1 receptors, as well as antibodies which bind to this cytokine and suggests their use to mediate IL-1 related disorders. Smith, et al., Science 248 1019-1023 (May 25, 1990) discusses the role of soluble receptors for tumor necrosis factor (TNF) and potential value in therapeutic environments. The above referenced disclosures are incorporated by reference herein. In fact, soluble IL-1 receptor has been reported to inhibit rejection of heart transplants, and is suggested as being useful in treating diseases such as rheumatoid arthritis and multiple sclerosis where stimulation by IL-1 is involved. See Kolata, "Test Drug Blocks Rejection of New Hearts In Mice", New York Times, May 11, 1990.
Fairly recent work has identified a new member of the interleukin family, the molecule referred to by Hultner, et al., in Eur. J. Immunol. 20: 1413 (1990), as interleukin 9. This paper, the disclosure of which is incorporated by reference herein, sets forth research which shows, inter alia, that the molecules previously known as P40 (Uyttenhove, et al., PNAS 85: 6934 (1988)), and TCGFIII (Schmitt, et al., Eur. J. Immunol. 19: 2167 (1989)), as Well as by Yang, et al., Blood 74: 1990 (1989), and Renauld, et al., Cytokine 2: 9 (1990), are the same. All of the foregoing papers are incorporated by reference herein. This molecule has been shown to possess many properties, including the ability to support the growth of helper T cell clones and mucosal mast cells. The latter are known to be involved in regulation of type I hypersensitivity reactions.
Druez, et al., J. Immunol. 145: 2494-2499, Oct. 15, 1990, the disclosure of which is incorporated by reference, and U.S. Ser. No. 585,229, filed Sep. 19, 1990, the disclosure of which is incorporated by reference herein describe the discovery and isolation of a receptor for interleukin-9, referred to as IL9R.
The IL9-R molecule is a glycoprotein which is characterized by a molecular mass of about 64 kilodaltons. Upon treatment with N-glycosidase F, the glycoprotein is digested to a peptide having a molecular weight of about 54 kilodaltons. Apart from binding to IL-9, the receptor may also be characterized in terms of its sources, which include IL-9 dependent cell line TS1. However, the activity of IL-9 on various cell types (Uyttenhove et al., Proc. Natl. Acad. Sci. USA 85: 6934 (1988); Van Snick et al., J. Exp. Med. 169: 363 (1989), Simpson et al., Eur. J. Biochem. 183: 715 (1989); Schmitt et al., Eur. J. Immunol. 19: 2167 (1989); Yang et al., Blood 74: 1880 (1989), suggests additional sources as well.
It has now been found by the inventors that IL-9 plays an important role in potentiating the effect that IL-4 has on the stimulation of IgG and IgE productions. This discovery, together with the discovery of a receptor for the IL-9 molecule itself, paves the way for a method of reducing the production of IgE in a subject. It is this, as well as a method for stimulating IgG production both in vitro and in vivo, in addition to a method for evaluating efficacy of anti-allergic treatment as well as a method for monitoring chronic diseases where abnormal IgE production is a feature that are the subjects of this invention.
FIG. 1 shows the dose related effect of IL-4 on IgE production by normal human peripheral blood lymphocytes in vitro.
FIGS. 2A and 2B depict the effect of recombinant human and recombinant murine IL-9 on IL-4 induced IgE production by normal human peripheral blood lymphocytes in vitro.
FIG. 3 presents data showing the effect of recombinant human and murine IL-9 on IL-4 induced IgG and IgM production by normal human peripheral blood lymphocytes.
Cells and cell cultures were prepared as follows: Peripheral human blood lymphocytes (PBLs) were isolated from heparinized blood of healthy donors. The mononuclear cells were separated using Ficoll/Hypaque gradient methodology, and monocytes were removed by incubating the PBLs with 5 mM L-Leucine methyl ester (LME) in serum RPMI medium for 45 minutes at room temperature, following Richard, et al., J. Immunol. 139: 1563 (1987). The thus treated population was washed twice, and is referred to hereafter as "LME-treated PBLs" or LME-treated E- cells.
Semi-purified B lymphocytes ("E- cells" hereafter) were obtained via rosetting once with neuraminidase treated sheep red blood cells, following plastic adherence for 1 hour at 37� C. When LME-treated PBLs were used, no plastic adherence was necessary.
In order to cause IgE production, the E- cells, which were found via flow cytometry to contain 45% CD20+, 35% CD3+, and 10% CD14+ cells, or LEM-treated E- cells, which were found via flow cytometry to contain 55% CD20+, 40% CD3+ and less than 1% CD14+ cells, were incubated at concentrations of 2�106 cells/ml in complete medium (RPMI 1640 medium supplemented with 10% heat inactivated FCS (i.e., fetal calf serum), 2 mM glutamine, 100 U/ml penicillin, 100 ug/ml streptomycin and 20 mM HEPES), at 37� C. in a 5% CO2 humidified atmosphere, using different doses of interleukin 4 (purchased from Biotrans (30 or 300 U/ml) and/or doses of either recombinant human or recombinant murine IL-9 (1/100-1/10,000 v/v for the human variety and from 1 to 1000 U/ml of murine form) prepared following Renauld et al., Cytokine 2: 9-12 (1990). After 9-10 days of culture, cell free supernatants were collected, centrifuged (500 g, 10 minutes) and stored at -20� C.
Assays were carried out to measure production of IgE, IgG, and IgM. For IgE, flat bottomed microtiter plates were coated with rabbit anti-IgE (obtained from Aerotic), at 1:2000 dilution in bicarbonate buffer (pH 9.6), with overnight incubation at 4� C. After this, the plates were washed 4 times with phosphate buffered saline/0.05% Tween and were incubated for 1 hour with RPMI 1640/10% FCS i.e., fetal calf serum) at room temperature, so as to saturate protein binding sites. After washing, dilutions of culture supernatants and of IgE standards in PBS-Tween 0.05% were added to the plates. After 2 hours of incubation, plates were washed, and 200 ul dilute alkaline phosphatase-anti IgE conjugates (obtained from Serotec (1:250) were added. Following 2 hours of incubation at room temperature, the plates were washed and 200 ul of p-nitrophenylphosphate in diethanolamine buffer was added. The plates were incubated at 37� C., and optical densities were measured at 405 nm using an autoreader. The sensitivity of this assay was 100 pg/ml.
To perform IgG and IgM assays, the same protocol was followed, except that plates were coated with either rabbit anti-human IgG (obtained from Behring) (1:2000) or rabbit anti-IgM (obtained from Behring) (1:1000), and the conjugates used were conjugates of IgG and alkaline phosphatase (ALP) or IgM-ALP (both conjugates obtained from Behring). For IgG, following the ELISA, amounts of each Ig isosubtype were calculated using a computer connected in series. Sensitivities were 1 ng/ml (IgG), and 2 ng/ml (IgM). When duplicate experiments were run, the standard deviation never exceeded 10% between samples.
The data show that when the E- cells were cultured in the presence of IL-4, IgE was produced in dose dependent manner after 9 days of culture. This is as predicted by Pene, et al., PNAS 85: 6880 (1988); Pene, et al., Eur. J. Immunol. 18: 929 (1988), and Vercelli, et al., J. Exp. Med. 169: 1295 (1989). As shown by FIG. 1, a maximum effect is reached at 300 U/ml. Under these conditions, neither type of IL-9 used alone induced IgE synthesis even at the relatively high concentrations of 1/100 v/v for human and 1000 U/ml for murine forms. However, when less than optimal doses of IL-4 (100 U/ml) were used in connection with IL-9, IgE production was upgraded. This is a potentiating effect, seen to a much smaller degree, when the optimal dose of IL-4 (300 U/ml) was used. FIG. 1, and Tables I, II and III, which follow, set forth these data.
TABLE I______________________________________Effect of both human (h) and murine (m)IL-9 on Ig production by E cells. IgG IgM IgEChallenge (ng/ml) (ng/ml) (pg/ml)______________________________________Medium 85 � 2 25 � 3 <100IL-4 195 � 7 20 � 1 4,775 � 450h-IL-9 78 � 5 24 � 2 <100m-IL-9 80 � 2 19 � 6 <100______________________________________ E cells were incubated with medium alone or an optimal dose of IL4 (300 U/ml), hIL-9 (1/1,000 v/v) or mIL-9 (300 U/ml) for 9 days and the cell free supernatants were then assayed for their IgG, IgM and IgE content as described in materials and methods. The data represent the mean � SD o a duplicate experiment representative out of 3.
TABLE II______________________________________Effect of human (h) and mouse (m) IL-9 on IgE productionby E- cells stimulated with an optimal dose of IL-4. IL-4 IgEChallenge (300 U/ml) (pg/ml)______________________________________Medium - <100Medium + 13,775 � 675h-IL-9 - <100h-IL-9 + 17,456 � 456m-IL-9 - <100m-IL-9 + 20,234 � 389______________________________________ E cells were cultured in medium alone or in medium containing 300 U/ml of IL4 and were challenged or not with an optimal dose of either hIL-9 (1/1,000 v/v) or mIL-9 (300 U/ml). After 9 days of culture the cell free supernatants were assayed for their contents in IgE as described in materials and methods. The data represent the mean � SD of a duplicate experiment representative out of three.
TABLE III______________________________________Effect of both human (h) and mouse (m) IL-9 on IL-4-induced IgE production by E and LME-treated E cells. IL-4 IgECells (100 U/ml) Treatment (pg/ml)______________________________________E - Medium <100" - h-IL-9 <100" - m-IL-9 <100" + Medium 3,975 � 556" + h-IL-9 18,776 � 765" + m-IL-9 25,660 � 456LME-E - Medium <100" - h-IL-9 <100" - m-IL-9 <100" + Medium 1,395 � 346" + h-IL-9 9,996 � 259" + m-IL-9 11,567 � 243______________________________________ Cell populations from the same donor were incubated with medium alone or 100 U/ml of IL4 in the presence or in the absence of hIL-9/P40 (1/1,000 v/v) or of mIL-9/P40 (300 U/ml). Culture supernatants were harvested afte 9 days and assayed for their IgE concentration as described in materials and methods. The data represent the mean � SD of a duplicate experiment representative out of 3.
These data also provide insight into the effect of monocyte depletion of IL-4's role with respect to human B lumphocytes. Recently, is has been proposed that endogenous release of monocyte derived factors could potentiate the effect of IL-4 on B cells. See Dugas, et al., J. Lipid. Med. 2: 197 p. 198, abstract 38 (1990), and Dugas, et al., Lipids, 1990 (in press). Thus, it was of interest to determine if IL-9 could potentiate IL-4 even after removal of monocytes and LME treatment. As Table III shows, IL-4 induced IgE production significantly decreased after LME treatment, but both forms of IL-9 still potentiated the effect. Thus, while the amount of IgE produced decreased, the IL-9 clearly potentiates production even in the absence of the monocytes.
Prior work had shown that IL-4 induces IgG production, but not IgM production. Pene, et al., Eur. J. Immunol. 18: 1929 (1988). The results shown in Table I, and FIG. 3 indicate agreement with the earlier studies as to IL-4's effect on IgG and IgM and show that IL-9, which had no effect on Ig by itself, did potentiate IgG with IL-4, but had no effect on IgM.
These results show that a combination of IL-4 and IL-9 can be used to increase the production of IgG by antibody producing cells. This is important not just for in vivo types of treatment, but also for cell culture such as hybridoma culture, or culture of other antibody producing cells, where IgG production is important. Thus, the invention relates not only to a method for potentiating the IgG response in an animal such as a human, but also to the enhancement of IgG production in vitro, by adding IL-4 and IL-9 together in an amount sufficient to potentiate the IgG production of the cells. The amount will vary; however, as has been shown, desirably the amount of IL-4 is a concentration of less than about 300 U/ml, preferably about 100 U/ml, while the amount of IL-9 used varies. A preferred amount is about 300 U/ml when murine IL-9 is used, and a concentration of about 1/1000 (v/v) when human IL-9 is used. The form of the cytokine used may be the naturally occurring molecule, or the recombinant form, the latter type being especially preferred. In connection with the inhibition of IgE production, again the amount of inhibitor may vary, depending on the material used, soluble receptor for IL-9 ("IL-9R"), e.g., is preferably used in a range of from about 10 μg/kg to about 250 μg/kg, preferably about 100 μg/kg of the subject. Other inhibitors, such as anti-receptor antibodies and other antigonists may be administered in amounts ranging from about 5 mg/kg to about 200 mg/kg, preferably 10 to about 100 mg/kg. "Kg" of course, refers to the body weight of the subject.
The effect of IL-9 on potentiating IgE production also leads to a method for reducing or suppressing this production. The IL-9 molecule is known to require interaction with a receptor, i.e., "IL-9R" in order to exert any effect on the cell. To that end, the effect of IL-9 on cells may be reduced or eliminated by administering an inhibitor in an amount sufficient to reduce or eliminate the IgE potentiating effect. Such an inhibitor may be, e.g., an antibody against IL-9 or soluble IL-9R receptor. When "antibody" and "receptor" are used herein, they embrace not only the whole antibody or whole receptor, but also fragments of these molecules sufficient to react with and inhibit the IL-9. Other inhibitors will be recognized by the skilled artisan.
In addition, given the observation that IL-9 is produced during an allergic response, the efficacy of anti-allergy therapy may be determined by measuring IL-9 content of a sample, and relating this measurement to a given standard. Increases or decreaes over that standard would be reflective of the status of anti-allergic therapy.
The terms and expressions which have been employed are used as terms of description and not of limitation, and there is not intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, it being recognized that various modifications are possible within the scope of the invention.
|Druez et al., J. Immunol. 145 (8):2494 2499 (Oct. 15, 1990).
|Druez et al., J. Immunol. 145 (8):2494-2499 (Oct. 15, 1990).
|Fanslow et al., Science 248:739 741 (May 11, 1990).
|Fanslow et al., Science 248:739-741 (May 11, 1990).
|H ltner et al., J. Immunol. 142:3440 3446 (May 15, 1989).
|Hultner et al., J. Immunol. 142:3440-3446 (May 15, 1989).
|Knight, Bio/Technology 8:717 719 (Aug. 1990).
|Knight, Bio/Technology 8:717-719 (Aug. 1990).
|Moeller et al., J. Immunol. 142:3447 3451 (May 15, 1989).
|Moeller et al., J. Immunol. 142:3447-3451 (May 15, 1989).
|Renauld et al., Cytokine 2(1):9 12 (Jan., 1990).
|Renauld et al., Cytokine 2(1):9-12 (Jan., 1990).
|Renauld et al., J. Immunol. 144(11):4235 4241 (Jun. 1, 1990).
|Renauld et al., J. Immunol. 144(11):4235-4241 (Jun. 1, 1990).
|Suda et al. (Mar. 1, 1990) J. Immunol. 144(5):1783 1787.
|Suda et al. (Mar. 1, 1990) J. Immunol. 144(5):1783-1787.
|Uyttenhove et al., Proc. Natl. Acad. Sci. USA 85:6934 6938 (Sep. 1988).
|Uyttenhove et al., Proc. Natl. Acad. Sci. USA 85:6934-6938 (Sep. 1988).
|Van Snick et al., J. Exp. Med. 169:363 368 (Jan. 1989).
|Van Snick et al., J. Exp. Med. 169:363-368 (Jan. 1989).
|Whicher et al., Clin. Chem. 36(7):1269 1281 (Jul., 1990).
|Whicher et al., Clin. Chem. 36(7):1269-1281 (Jul., 1990).
|Yang et al., Blood 74(6):1880 1884 (Nov. 1, 1989).
|Yang et al., Blood 74(6):1880-1884 (Nov. 1, 1989).
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|U.S. Classification
|424/85.2, 424/85.1, 530/351, 514/20.9
|International Classification
|Cooperative Classification
|European Classification
|Dec 7, 1990
Owner name: DEPARTMENTE D IMMUNOLOGIE INSTITUT HENRI BEAUFOUR,
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text:
Intelligence, Heredity and Environment / Edition 1by Robert J. Sternberg
Pub. Date: 02/28/2009
Publisher: Cambridge University Press
Robert Sternberg and Elena Grigorenko address the roles and interaction of nature and nurture in Intelligence, Heredity and Environment, which provides a comprehensive, balanced, current survey of theory and research on the origins and transmission of human intelligence. The book is unique in the diversity of viewpoints it presents, and its inclusion of the most
Robert Sternberg and Elena Grigorenko address the roles and interaction of nature and nurture in Intelligence, Heredity and Environment, which provides a comprehensive, balanced, current survey of theory and research on the origins and transmission of human intelligence. The book is unique in the diversity of viewpoints it presents, and its inclusion of the most recent theories and findings. It highlights the search for genes associated with specific cognitive abilities, interactionist theories, cultural relativism, educational strategies, developmental perspectives and fallacies of previous intelligence research. This book will be required reading for students and professionals in the fields of intelligence, behavior genetics, biology, anthropology, and sociology.
Product Details
- 9780521469043
- Publisher:
- Cambridge University Press
- Publication date:
- 02/28/2009
- Edition description:
- New Edition
- Pages:
- 632
- Product dimensions:
- 5.98(w) x 8.98(h) x 1.42(d)
Table of Contents
Part I. The Nature-Nurture Question: New Advances in Behavior-Genetic Research on Intelligence: 1. Behavior genetics and socialization theories of intelligence: truce and reconciliation S. Scarr; 2. The puzzle of nongenetic variance A. R. Jensen; 3. Identifying genes for cognitive abilities and disabilities R. Plomin; 4. Heredity, environment, and IQ in the Texas Adoption Project J. C. Loehlin et al.; 5. IQ similarity in twins reared apart: findings and responses to critics T. J. Bouchard; Part II. Novel Theoretical Perspectives on the Genes and Culture Controversy: 6. The invalid separation of effects of nature and nurture: lessons from animal experimentation D. Wahlsten and G. Gottlieb; 7. Between nature and nurture: the role of human agency in the epigenesis of intelligence T. R. Bidell and K. W. Fischer; 8. A third perspective: the symbol systems approach H. Gardner and T. Hatch; 9. A cultural psychology perspective on intelligence J. G. Miller; 10. A bio-ecological model of intellectual development: moving beyond h2 S. J. Ceci et al.; 11. An interactionist perspective on the genesis of intelligence E. W. Gordon and M. P. Lemons; Part III. Specific Issues in the Nature-Nurture Controversy: 12. Educating intelligence: infusing the Triarchic theory into school instruction R. J. Sternberg; 13. Raising IQ level by vitamin and mineral supplementation H. J. Eysenck and S. J. Schoenthaler; 14. The resolution of the nature-nurture controversy by Russian psychology: culturally biased or culturally Specific? E. L. Grigorenko and T. V. Korilova; 15. The emerging horizontal dimension of practical intelligence: polycontextuality and boundary crossing in complex work activities Y. Engestrom et al.; 16. Cognitive development from infancy to middle childhood Stacey S. Cherney et al.; 17. Intelligence, language, nature, and nurture in young twins J. S. Reznick; 18. Sources of individual differences in infant social cognition: cognitive and affective aspects of self and other S. Pipp et al.; Part IV. Integration and Conclusions: 19. Conclusions E. Hunt; 20. Unresolved questions and future directions in behavior genetics studies of intelligence I. Waldman.
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