text:
Police show great patience while subduing a drug addict
as above.
By: Amusing | Comments: 35 | Views: 5017 | Votes: 1 | Shared: 7
Location: United States | Leaked: Apr-15-2012 in WTF
balls and patience = this
dont know where or why
By: freedomfighter | Comments: 19 | Views: 2521 | Votes: 1 | Shared: 0
Leaked: Sep-29-2011 in Other
US-Pak Relations : Haqqani links - Khar says US should not test patience
Pakistan's interior minister Rehman Malik has contended that the US should share the blame for the rise of the Haqqani network as the CIA created the Taliban faction during the Soviet occupation of Af
By: hummer101 | Comments: 46 | Views: 2153 | Votes: 1 | Shared: 0
Location: United States | Leaked: Sep-26-2011 in World News
Russian guy loses his patience in an elevator
Watch what happens then...
By: TahsinTekin | Comments: 32 | Views: 7440 | Votes: 3 | Shared: 21
Location: Russia | Leaked: Aug-12-2011 in WTF, Other Entertainment
Algerian fat cat has no patience for traffic cop
^ ^ ^ ^ ^ ^
By: TheSanityInspector | Comments: 4 | Views: 4087 | Votes: 0 | Shared: 0
Location: Oued rhiou, Relizane, Algeria | Leaked: Aug-4-2011 in Other Middle East, WTF, Citizen Journalism
BP faces extra $60bn in legal costs as US loses patience with Gulf clean-up
The oil disaster unfolding in the Gulf of Mexico could present BP with much higher costs than previously thought as a result of US government penalties of up to $60bn (£40bn), according to City analy
By: shibz84 | Comments: 31 | Views: 7168 | Votes: 1 | Shared: 1
Leaked: May-27-2010 in News
Russian cops lost patience
It was February 28, 2010 at 9.00 am Ryazan Internatsionalnaya street near d.19 k.1 DPS officers do not know the law, by the way they are still working within the Ministry of Internal Affairs. though
By: RoMa23 | Comments: 163 | Views: 69531 | Votes: 7 | Shared: 3
Location: Ryazan, Ryazan', Russia | Leaked: Mar-10-2010 in Arts and Entertainment
Idiot Tests The Patience Of A Reporter During Live Broadcast
Robert Deniro has a son?
By: ghastlyghost | Comments: 177 | Views: 72107 | Votes: 34 | Shared: 5
Leaked: Jan-31-2010 in Arts and Entertainment, Other
Let Patience Control Health Care Not The Government
Rep. Gohmert rails against the Democrats' plan for socialized, government takeover of health care, warning about rationing, outrageous wait lists for life saving treatments, and bureaucratic red tape.
By: ubdumb | Comments: 3 | Views: 3915 | Votes: 1 | Shared: 0
Leaked: Jul-28-2009 in News
Cat With The Patience Of A Saint.
Poor cat is well outnumbered...:(
By: barnesy | Comments: 3 | Views: 5439 | Votes: 1 | Shared: 1
Leaked: Jul-7-2008 in Arts and Entertainment
Sunni Forces Losing Patience With U.S.
Citing Lack of Support, Frustrated Iraqi Volunteers Are Abandoning Posts By Sudarsan Raghavan and Amit R. Paley Washington Post Foreign Service Thursday, February 28, 2008; Page A01 BAGHDAD, F
By: PutzwithNutz | Comments: 12 | Views: 2056 | Votes: 0 | Shared: 0
Leaked: Feb-28-2008 in Iraq, News, Middle East
An office worker loses his patience and...
..kicks the &^$%# out of the employee who pissed him off. And as usual, one never ceases to be amazed by the passiveness of people when there is dire need for help. It is worse in this case because it
By: Benji1 | Comments: 17 | Views: 6561 | Votes: 0 | Shared: 2
Leaked: May-1-2007 in Other
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This was posted at AP on November 5 of 2014: American Power: Why the Democrats Got Crushed — Totally Freakin' Crushed! — And Why They Have No 2016 Lock It's a good piece, although I'm again going to disagree on … Continue reading
Category Archives: Unexpectedly
After Minimum Wage Hike, UC Berkeley Cuts 500 Staff – Breitbart On Monday, University of California Berkeley chancellor Nicholas Dirks announced that the educational institution will be eliminating 500 jobs over the course of two years, which will wind up … Continue reading
What Does Islamic State Think It Is Doing? – Bloomberg View Thus, while Islamic State has now proved an unexpected capacity for overseas attacks, the end result will almost certainly be a quicker demise of the original political-messianic project. Unexpected … Continue reading
Rising: 25,098,000 Foreign-Born Workers Employed in U.S.A. (CNSNews.com) – The number of foreign-born individuals holding jobs in the United States increased by 279,000 to 25,098,000 in May, according to data released Friday by the Bureau of Labor Statistics (BLS). In … Continue reading
When Minimum-Wage Hikes Hit a San Francisco Comic-Book Store | National Review Online 'I'm hearing from a lot of customers, 'I voted for that, and I didn't realize it would affect you.'" So says Brian Hibbs, owner and operator of … Continue reading

subset: commoncrawl


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Keep the Opportunities, Lose the Opportunists
Loss of Lives in Clinical Trials...
Capitol Hill Critics Second-Guess Agencies Using...
Clinical-Style Validation, Regulation, and Quality Control...
A group of scientists have found that embryonic stem cell (ESC) pluripotency can be retained even when these cells do not have close cell-cell contact through colony formation. Based on this discovery, the team was able to create a culture method independent of animal-derived matrices.
Currently human ESCs are grown on Matrigel-coated culture plates, which use a gelatinous extract from mouse tumor cells that contain extracellular matrices (ECMs). hESCs first attach to these scaffolds and then grow in undifferentiated colonies before differentiating into specialized cells. This process of colony formation was assumed to be pivotal to maintaining pluripotency, according to Noboru Sato, M.D., Ph.D., an assistant professor of biochemistry at University of California, Riverside.
Dr. Sato and colleagues identified a signaling pathway called Rho-Rock, which the ESCs use during colony formation and which plays a role in physical interactions. When the investigators blocked the pathway in mice with a chemical called Y27632, normal colony formation of mouse ESCs was considerably impaired as expected. Surprisingly, however, the ESCs maintained their pluripotency. The researchers say that this pathway is essential for the regulation of basic cell-cell communications in both mouse and human ES cells.
The scientists then developed a culture medium replacing the Matrigel coating with poly-D-lysine, a chemically synthesized ECM, and combined it with the Rock inhibitor. This system fully warranted ESC self-renewal and was entirely independent of animal-derived matrices as well as tight cell contacts. "We found that the growth of the hESCs under this novel culture condition was almost identical to the growth of hESCs on Matrigel-coated culture plates with no compromise in pluripotency," says Dr. Sato.
The research was a collaboration between UCR and the National Institute of Environmental Health Sciences. The results appear online in the August 20 issue of the Public Library of Science ONE.
The group is now focusing on applying the technique to induced pluripotent stem cells.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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(WEST HOLLYWOOD, CA) -- It's no secret celebrities are flocking to the new Apple Lounge, located at 665 N. Robertson in the heart of West Hollywood. Paparazzi camp out nightly to catch the likes of regulars Paris Hilton, Lindsay Lohan, Chris Evans, Perez Hilton and more. But wait until they get a load of the scantily clad crowd Chi Chi Larue and Jason Sechrest bring to Apple's new Thursday night promotion!
West Hollywood nightlife heavyweights Jeffrey Sanker and Paul Nicholls will team to bring ''Temptation'' every Thursday to the three-level night spot, the underground dance club for which will see Chi Chi LaRue's Pop 'N Cock Lounge. Each week, Larue brings the pop and Sechrest brings the cock as the drag diva directrix-come-DJ spins the tunes and Sechrest serves as VIP host, bringing a porn star guest each week to the venue, the first of which for the club's launch this Thursday, October 9th is none other than adult video superstar, Johnny Castle. This will be followed by Francois Sagat (appearing courtesy FabScout.com) on October 16th, Tyler Saint on October 23rd and Channel 1 Exclusive, Benjamin Bradley on October 30th. Larue will appear as DJ any week she's in town, this month appearing on the 9th and the 30th.
Unlike Sechrest's several other porn promotional nights in West Hollywood, ''Temptation'' won't have the porn stars guests getting grilled on the mike or even dancing on stage. Instead, the club will feature more of what Sechrest describes as ''an exclusive Playboy Men's Club vibe'' with the adult film stars walking around in their underwear, mingling one-on-one with guests -- and for the high class patrons who order champagne bottle service, Sechrest will offer for the porn celebs to give them lap dances for tips! It's the closest you can get to some of the biggest names in the gay adult entertainment world.
''to be asked to be a part of an evening that is put together by Jeffrey Sanker and Paul Nicholls is really the ultimate for any host in the West Hollywood area,'' says Sechrest. ''They're bringing in other high profile local socialites and celebutantes like Chad Hudson, Woody Woodbeck, Jonathan Chang and Bobby Trendy to make this the hottest nightclub in West Hollywood each and every Thursday night. And on a personal level, to have one of my own best friends, Chi Chi Larue, there with me throwing this massive party each week is just like the icing on the cake.''
The grand opening of Apple Lounge's ''Temptation'' is this Thursday, October 9th, featuring host with the most Jason Sechrest, DJ drag diva Chi Chi Larue and super stud Johnny Castle. Apple Lounge is located at 665 N. Robertson Blvd. In West Hollywood. Doors open at 9:00 PM. Arrive early for no cover!
Press and media outlets or adult industry insiders interested in attending the event, please contact Jason Sechrest at firstname.lastname@example.com to get on the VIP Guest List before 4:00 PM This Thursday!!!
for further information, interview bookings, promotional appearances and more, please contact:
Jason Sechrest / DV8 Public Relations 8205 Santa Monica Blvd. #1-175, West Hollywood, CA 90046 Phone/Fax: (323) 650-1952 AOL Im: JasonSechrest
News Rack: 2015 ED Expo
ED Expo Returns to NO
Katrina Jade GOTM
Marica Hase Official Site
CatalystCon Sessions, Speakers
World Bukkake Tour
Cum Swallowing Auditions
Venus Anniversary 20
BBWcon Takes Over Vegas
Freedom Acres Party
Porn Star by Herschel Savage
TexXxas Fan Event
Shawna Lenee Dogfart GOTM
Paradise Marketing New Website
GFE at Sheri's Ranch
Samantha Hayes Interview
Dead But Dreaming ~ Reviewer Rated
Dava Foxx Self-Booking
Gina Valentina's 1st IR
Submission of Emma Marx: Exposed ~ Reviewer Rated
BBWcon 2016
New Webcam Opportunity
NaughtyAllie Facelift
Nina Elle MiniView
Kahlista Stonem Available
Sanders, Trump Joint News Conference
Naughty Massage
Redefining the Status Quo
Jenevieve Hexxx at Trixie's
Ocean News from Lexi Love
Hard Squeezes
APAC and Sex Worker Rights
New From Rodney Moore
RNSU Radio Thurs March 24
New Girls
What We Signed Up For
The Directors
What is Consent?
Bee, Evans at Sexpo
New Gay News Site
Alana Evans on MTV
Sexpo Cosplay
Cruz Receives Porn Offer
Poking Around AVN 2016
Deadly Famous
Planet Venus
The Hedge Against Exploitation
Performers File Unpaid Wage Claims
Carnal Comedy at Sapphires
Kendra Sunderland at Sapphire NYC
Gentlemen's Club Live Feed
Leya Falcon at AFFLV
Morgan, Lindemulder Headline Exxxotica
Cindy Starfall Appearances
Priya in NYC
Tony Batman to Big Easy
Elizabeth Bentley Hits Circuit
Allie Haze in Columbus
Vivid NYC Nommed
Raven Bay at Exxxotica
Little Sassee Cassee in OK
Dee, Michaels in Alabama
Nikki Benz Headlines Ohio
Galaxy Stars to Exxxotica
Caribbean Playground Party
Throwback Expo Registration Rates!
Tanya Tate at Comic Con
Bridget the Midget at Vivid Houston
Ideal Image Supperclub Party
Angela Sommers in Houston
Starfall to Exxxotica
Prinzzess at Treasure Chest
Danica Dillon in Bath
Library Girl at Exxxotica
ED Awards Host Thea Vidale
National Porn Star Day
Strippers Ready for Baseball
Karaoke XXX Needs New Location
ED Expo to Big Easy
Layla Price at Foxxx Booth
Nikki Phoenix Party
Viva Las Vicki
Kendra Lust in Detroit
Starr Sisters in Houston
Nikki Phoenix Update
Vegas Heat Party
XBIZ Rooftop Party
Heaven & Hell Halloween Party
Farrah Abraham at Hustler Hollywood
Amber Lynn at Wasteland
Stripclub Microbrewery on CNN
Nikki Phoenix Karaoke XXX
Asianmodelpalooza 14
Nikki Phoenix Appearances
Clubs & Appearances Section Index


text:
Saturday, 30 July 2016
Last updated 12 hours ago
Jun 8 2012 | 12:20pm ET
Two Denver hedge fund managers and their tipster have settled insider-trading charges with the Securities and Exchange Commission.
Drew Brownstein, Drew Peterson and H. Clayton Peterson agreed to pay $4.7 million, the SEC said. Much of that total has already been covered by forfeitures in the criminal cases against the trio, but Brownstein and his Big 5 Asset Management hedge fund were levied a further $2 million.
Brownstein is currently serving a year in prison for trading on a tip from H. Clayton Peterson through Drew Peterson. The elder Peterson served on the Mariner Energy board of directors, and told his son that the company was about to be acquired by Apache Corp. Brownstein earned $2.5 million for Big 5 and members of his family on the tip. The Petersons received house arrest and probation for their participation in the scheme.
Brownstein now owes the SEC $130,671, in addition to the roughly $2.4 million in disgorgement still owed by Big 5.
Jul 8 2016 | 7:01pm ET
Recent market volatility has investors seeking greater insight into alternative...
Jul 25 2016 | 6:29pm ET
If you are compelled by stories of entrepreneurial vision & drive, or simply...
Jul 22 2016 | 8:44pm ET
When the press reports extraordinarily strong relative or risk-adjusted returns...


text:
The Man With Two Faces;In an Orthodox Jewish World of Honor, a Fraud Case Shocks
Published: June 16, 1996
(Page 2 of 2)
Former associates, speaking on the condition of anonymity, say the allegations do not square with Mr. Schick's personality and surmise he may have become desperate for money to cover investors' losses in previous deals. Clearly, some investors did win. William J. Davis, a lawyer representing the Wertenteil family, said the family's late father, Louis, made various loans and investments with Mr. Schick and always made money. But $424,000 lent to Mr. Schick by Wertenteil family members and others to be repaid in March, with interest, has not been repaid by Mr. Schick, according to a lawsuit filed by the family in Supreme Court in Manhattan.
"Sometimes a snowball gets rolling and keeps going and going and it can't be stopped," said Mrs. Katz, who added that she knows nothing about her son-in-law's business.
Although Mr. Schick evolved into "a deal junkie," as one former associate said, he hardly came off as slick. His shirt tail was often in evidence, he had none of the trappings that telegraph success, and he was more harried than high-pressure. His frenzy was reflected in his personal communications network: Two beepers, a cellular phone, a car phone, a paging service and three telephone lines at home. "He was a workaholic," Mrs. Katz said. "He just couldn't stop."
Rather than enter the family's catering business (the family sold the bakery years before, although it still bears its name), he became a lawyer. He graduated from Brooklyn Law School and transformed a real estate law practice into an investment business that he said owned or managed property and mortgages valued at $277 million, according to a confidential report he wrote last summer on his company, the Venture Mortgage Corporation. He dealt largely with other Orthodox Jews in a business atmosphere not unlike the diamond business, where deals are struck on trust and a handshake.
He was equally energetic in charitable work. He gave money and free legal advice to established charities, and also helped the needy informally, including letting a family of Russian immigrants live rent free in an apartment in his house for six years. "It was not a tangential part of his life," said his uncle, Marvin Schick, who was an adviser to Mayor John Lindsay. Now, investigators and former associates suspect his largesse was fueled by other people's money.
Mr. Schick made inroads in politics. He contributed $25,000 to the Democratic National Committee in February. Through business associates, Mr. Schick met Susan Thomases, a New York lawyer and friend of the President and Mrs. Clinton. Ms. Thomases, who did not return calls seeking comment, attended the bris for Mr. Schick's newborn son, said two people who attended. And Ginny Terzano, a White House spokeswoman, said Ms. Thomases suggested that the President meet with about 40 donors and educators of the Lakewood Yeshiva, a meeting Mr. Schick helped arrange at the St. Regis Hotel in March.
Even as Mr. Schick became more prominent, there are indications his scheming and deceptions were becoming more widespread. A lawsuit filed last month in Federal Court in Manhattan alleges that in 1993 Mr. Schick acted as the attorney on the sale of five mortgages worth more than $6 million to the National Heritage Life Insurance Company but that he never delivered the mortgages to the insurance company. The insurance company, being liquidated, is the subject of a criminal investigation into allegations it was defrauded of as much as $100 million.
However adept he was at creating illusions, when Mr. Schick tumbled, he did not try to make it look like a planned stunt. His lawyer, Mr. Rocco, said Mr. Schick was cooperating with authorities in identifying people who lost money.
Mr. Rocco wrote to a leader in the Orthodox community, Abraham Fruchthandler, proposing that investors resolve their claims under the guidance of a rabbinical court rather than through a civil court. But the losses and the number of investors became too large. Two weeks ago, a group of investors petitioned to force Mr. Schick into bankruptcy, freezing his assets.
Some among the Orthodox call Mr. Schick a thief. But others have displayed a surprising compassion -- and some residual faith in Mr. Schick.
In mid-April, a distraught Mr. Schick appeared briefly at a meeting of about 25 investors and Orthodox community leaders who had come together to discuss how to deal with the missing money, including the possibility of creating a fund to cover some of the losses. The emotions at the meeting ranged from anger to embarrassment, but a few people offered to open their checkbooks again. "People said, 'I lost a lot of money,' said Mr. Schick's uncle Marvin, 'but he's a good person and I'd like to help.' "
Photo: David Schick leaving Federal Court in Brooklyn after having beencharged with defrauding investors of up to $200 million through various real estate schemes. (The New York Post)


text:
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Madness and civilisation: a history of insanity in the age of reason - Michel Foucault
Health and happiness: confronting the waste of human life through the pursuit of joy
How do we fight privatisation?
On capitalism, queerness and living with HIV/Aids - The Expropriationist
Angry Workers of the World - AWW #2 - On struggles in the health sector - Out now!
Room to breathe in defence of the NHS
Mid Yorkshire health strike
Victory – albeit limited – at San Raffaele hospital
After months of difficult struggle – in which workers blocked major roads, occupied rooftops and fought with police – an agreement has been reached at Milan's San Raffaele hospital. The agreement was reached with unions early on the morning of Friday 10th May, after 16 hours of negotiation, and was finally accepted by workers on the 16th after a series of assemblies.
Strikes and scuffles in Milan to defend public healthcare
Health workers across the Lombardia region took part in a 24-hour strike on Wednesday 8th May, as part of the ongoing struggle against 244 redundancies at San Raffaele Hospital. Already, 66 workers have been served with redundancy letters, effective immediately.


text: AdChoices Terms of Use Privacy Policy Hide TOP 10 Top 10 Fitness 2012 Fitness Essentials: Weekend Warrior Share Tweet 0 Shares 9. Athletic Body in Balance by Gray Cook Human Kinetics Every couple of years, our understanding of how our body reaches its physical peak changes. Physical therapist and sports conditioning expert Gray Cook is one such game-changer, illustrating in his book how athletes should be using a variety of functional movements and exercises -- like jumping, kicking, cutting, and turning --in order to improve and expand their athletic potential. If guys in the NFL, NBA and NHL follow his work, weekend warriors should too. Next Page TOP 10 9 8 7 6 5 4 3 2 1 Comments Share your opinion Your name More Like This Fitness & Workouts 7 Exercises That Will Quickly Add Muscle To Your Frame Read More Fitness & Workouts These Progress Pics Are Proof That Anyone Can Bulk Up Read More Fitness & Workouts This Workout Plan Will Help You Gain 10 Pounds Of Muscle In Just 12 Weeks Read More Fitness & Workouts We're About To Make It Super Easy For You To Achieve The Perfect Deadlift Read More Fitness & Workouts How One Actor Got Ripped For Elysium In 3 Months Read More Sponsored Ad Content Fact: You Aren't As Cut As You Could Be Read More Around the Web Special Features Guy Gear The Best Watches Under $500 Read More Special Feature The Ultimate Guide To Hooking Up Online Read More


text:
Skip to comments.End of the week: Foxs OReilly thinks Holder will have to resign(gunwalker)
Posted on 10/15/2011 5:41:44 AM PDT by marktwain
It has been a tough week for Attorney General Eric Holder, despite an attempted defense by Democrat spinmeister Lanny Davis, and it was wrapping up Friday morning with Fox News Bill OReilly predicting Holder will have to resign, and Sen. Charles Grassley saying he will ask for the resignation of whomever signed off on Operation Fast and Furious.
I think hes going to have to resign.Bill OReilly
For an administration that came into office in 2009 promising to be the most transparent in history, the Obama administration is suddenly drowning in scandals. Not only is there Fast and Furious, but there is also Solyndra a controversy that has nothing to do with firearms or gun rights, but everything to do with how this administration has evidently been conducting its affairs.
This column will focus on Fast and Furious, because this could be the career killer, not only for Holder, but for several career bureaucrats at the Bureau of Alcohol, Tobacco, Firearms and Explosives. Advertisement
OReillys remarks came during a segment of the morning show Fox and Friends. He appeared just days after an exchange on his own program with former prosecutors Lis Wiehl and Kimberly Guilfoyle, both of whom also thought Holder is essentially toast. This column discussed that.
For his part, Davis writing in The Hill is attempting to spin the Fast and Furious probe as nothing more than crass partisanship, and he wants it to end. Of course he does, as do all Democrat Obama loyalists, because they recognize this as an anchor that could drag down their president in 2012.
(Excerpt) Read more at examiner.com ...
BOR sure does have a mind like a steel trap doesn't he? /sarc
wtf cares wot 0'pinhead ?thinks......
He needs to resign for sheer incompetence since his Boss admitted he knew about Gunwalker in March..and Holder didnt' know???? Yeah right.
I think that's all part of Issa's plan. He knows he has Holder caught, and he's still working on nailing the boy king from Kenya.
I sense a bit of wishful thinking here. There is no way these guys ever resign. Their office is the source of their power. And they would happily provoke a constitutional crisis and/or revolution rather than leave office. And even that would be after YEARS of stringing out the legal process.
Holder is the bar no the front door. If Issa can make him fall, the others will turn to CYA mode knowing they're next. Once they begin eating their own, then the investigation will be producing results.
Holder is the bar on the front door. If Issa can make him fall, the others will turn to CYA mode knowing they're next. Once they begin eating their own, then the investigation will be producing results.
Allowing Holder to merely resign is a slap to the faces of the American people generally, and particularly the families of those killed by the firearms at the center of this politically sanctioned criminal enterprise.
Holder and all his minions with a hand in this debacle must be held accountable. And the accountability should extend to White House, if the trail leads there, as well.
Who will be the first to knock on Issa's door and ask for amnesty in return for their testimony?
KNOCK-KNOCK: Who's there?
Answer - ISSA
O Aide - Oh, Ok Is sa gonna answer but first can we talk
'Fox Friends' discussing same with Mike Huckabee. Be interesting to see what eventually unfolds. Obama is not just 'friends' with Holder; they are as "thick as thieves". A special relationship, indeed.
To be honest, I watch BOR as much as I watch/listen to Ubama. Not at all.
They are both a waste of time and energy.
This story on a 'slow crawl'. A perfect 'gotcha' that only deepens the swamp that surrounds Obama,Inc.
If you care what Bill O'Reilly thinks, well....
And if you don't, ignore this ping.
That's not enough.
I want him prosecuted, found guilty, disbarred, fined into penury, sent to the hard-time federal pen, turned into a house mouse for a gang of skinheads and fed nothing but mayonaise sandwiches on Wonder Bread.
The Boy King from Kenya is more aptly described as the Wannabe Dictator who decides who lives and who dies with the aid and support of Pelosi, Reid, and the rest of the human waste in the US Congress and in this Regime.
I can't stand the bloviator. But I am interested in F&F so I'll not ignore the thread :)
That is fine, of course....but do I hear the sound of a 'steel trap' closing?
Could we also get BOR to retire also?
TED: (on the air) In order for the bill to be passed, it has to be ratified by two-thirds of the forty-eight states.... (looks off camera, sees a crewman holding up two fingers) Oh, two more, huh? Correction, that's four-thirds!
"I sense a bit of wishful thinking here. There is no way these guys ever resign. "
I agree. Chances are maybe 1 in 50.
Good shot!
I get enough after action reports to know that both of them are so full of crap that their eyes are brown.
Resign? Bull Cookies!
This man and his accomplices need to be prosecuted and go to jail! Every one, all the way down...and up the ladder!
Find O'Reilly
Were BOR turn up missing, I would not join the Search Party to go find him.
"I think hes going to have to resign.Bill OReilly" We should be so lucky. These people have incredible (and distasteful) chutzpah (sp?).
(Think much of O'Reilly hype is an honest Blarney; whereas that color/substance you mention, IS Obama's core value.)
That said, am not discounting O'Reilly's often noxious or boorish behavior. Do think, as well; he is not as well served by his staff as he imagines. Am not an O'Reilly regular; but appreciate his viewer draw and target topics - and the fact, that Libs land on 'Fox' to watch him.)
No problem.
You can watch BOR so I don't have to. :)
I remember at the first Tea Party protests, I heard that Lanny Davis was pushing for the car tags of attendees to be photographed.
You're right - his resignation can't be the end. The American people have the right to know the truth...
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Ian Somerhalder and Nikki Reed have been married since 26th Apr 2015. [view couple]
Ian Joseph Somerhalder (born December 8, 1978) is an American actor, model and director. He is known for playing Boone Carlyle in the TV drama Lost and Damon Salvatore in The CW's supernatural drama The Vampire Diaries....
Connect any celebrity with Ian Somerhalder to see how closely they are linked... romantically!
ian somerhalder em participação especial em CSI Las Vegas 3/1 também com a participação de carmine giovinazzo!
ian somerhalder in cameo on CSI Las Vegas 3/1 also with the participation of Carmine Giovinazzo!
I like very you Damon! Of Diarios de um Vampiro!
Hopefully his marriage will last a long time. He seems to really love her lots.
Sexy banner pic!
all i can say is i don't think Ian and Nikki are gonna last long anyway.
I can't believe he and Nikki Reed are engaged now.
Ian is not a good actor. what is so special about him??
another monkey wannabe celeb good in c0csucing
U better get back to the catwalk, u u g l y
chimp !
I really dont get the hype but oh well.
ian is a w***** ... Nina needs to get a new hot bf, just saying
Ian my man ! I love him, Nikki Reed is a lucky girl to have him by herside
this man now gets mad, because some fan don't like his gf, Ian starts becoming an ass..., go against the fans, because he feels too famous, and wants his privacy, I really don't care if he dating Nina or Nikki, but I missing the days, where we call "family".
At last the sanctuary was built, so probably he don't need anymore to doing the part of good guy...


text:
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AN Buildwell introduces option of 'Flexible Apartments' in India
People of Delhi and Northern fringes of India have reasons to celebrate in the season of Eid and upcoming Dussehra and Diwali! With the unbound joy of togetherness that these celebrations bring, they are now going to get spoilt for choice with incredible 'flexi homes' option from one of India's most a reputed construction company. AN Buildwell, the name behind north India's first World Trade Center, have come ahead with an offer in which, at the time of booking, the buyer gets the scope to customize the way his/her apartment would look. One gets the option to customize the floor layout, interior design of room, color on the walls and even flooring. Minute details like window panes to balcony railings are always included in the flexible list. The name behind all these is AN Buildwell (http://www.anbuildwell.in/
The inspiration behind this innovation
Leading the real estate industry for quite a long time, the praiseworthy management of the company realized the fact that in the real estate space everyone is just offering of-the-shelf offers to the buyer. In other words, no one is offering them the house that they desire, or perhaps would want to have. While a home is something with which one must be able to connect, when someone buys an apartment they remodel it according to their taste to go with their taste, the home begins to manifest the personality of the buyer/inhabitants of the space.
This very thought prompted them to come up with an option which will give them the scope to customize their apartment at the time of buying itself to turn it into home. This has been quite popular with the buyers of region and making quite a headline.
The Woods offer you with more
Once you begin your living in a place which is dressed the way you want it to be life become really memorable. Buyers get to choose from various sizes of apartments as per their need which comes in the form of 2, 3 and 4 BHKs. In total there are 520 apartments out of which 100 plus apartments are still up for possession. With location land facilities unparallel to none the place is still going to be the happy abode of 512 families.
Some highlights of the project
Major highlights which are drawing the attention of buyers towards 'The Woods' along with the customizable option are:
1. Its location being near to MG Road Metro Station.
2. Global amenities like swimming pool, club, recreation center and lush green garden area.
3. Having hospital, bank and school just around the corner.
4. Top-notch security with 24/7 CCTV coverage.
An Buildwell
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text: Product Home Switchers Switcher Accessories IR Remote Controls Control Panels Control Accessories & Kits Miscellaneous HDMI, DVI, & DisplayPort Switchers HD-SDI & 3G-SDI Switchers USB Switchers VGA & RGB Switchers AV Switchers System Switchers Scaling Presentation Switchers Seamless Switchers Media Presentation Switchers MLS Switchers CTR 8 CTR 8 IR 102 IR 102 Remote Control Kit Previous Next CTR 8 Eight Input Contact Closure to RS-232 Converter Print-friendly Save to Favorites ListRemove from Favorites List View Favorites List × Send Feedback Message: Required Send me a copy Thank you. Your email has been sent. An error occurred while sending your e-mail. Please try again later. Send Feedback × Share this item via Email Send to: * Please enter a valid e-mail address. Message: Thank you. Your email has been sent. An error occurred while sending your e-mail. Please try again later. Send Email Item has been added to Favorites List Item has been removed from Favorites List An error occurred. Please try again later. Key Features Adds contact closure control capability to most RS-232 controllable Extron single-output simple or scaling switchers Converts contact closure inputs to Extron SIS serial commands +5 VDC output to light an external LED Video muting control with selectable LED indication mode +12 VDC loop-out power port 1U, quarter rack width metal enclosure See All Features Image Gallery Log in to view pricing and availability Model Version Description Part # CTR 8 Contact closure to RS-232 60-1408-01 Overview Video Description Specifications Diagram Panel Drawing Downloads The Extron CTR 8 adds contact closure control to most RS-232 controllable Extron single-output simple or scaling switchers, or to an Extron IP Link control processor. The CTR 8 accepts up to eight contact closure inputs and converts them to SIS™ serial commands that select the corresponding input on an Extron switcher or allows the CTR 8 inputs to be controlled by an Extron IP Link control processor. Video can be muted and un-muted by pressing a single switch in sequence, allowing the user to control the viewing of the presentation. Each contact closure input features a +5 VDC output that can be used to light an LED to indicate the active switch. To streamline installation, a +12 VDC power loop-out port allows sharing of external power with another Extron product. Quick Reference CTR 8 (Brochure) TeamWork - CTR 8 (Brochure) CTR 8 Setup Guide (Manual) CTR 8 User Guide (Manual) INCLUDED ACCESSORIES MBU 123 Low-Profile Mount Kit for 1/8, 1/4, and 1/2 Rack Width Products 70-212-01 OPTIONAL ACCESSORIES ZipClip 200 Mounting Kit for 1/8 and 1/4 Rack Width Products SIMILAR PRODUCTS Backlit Button Labels Labels for Backlit Buttons Show all INCLUDED ACCESSORIES MBU 123 Low-Profile Mount Kit for 1/8, 1/4, and 1/2 Rack Width Products OPTIONAL ACCESSORIES ZipClip 200 Mounting Kit for 1/8 and 1/4 Rack Width Products × Add Item to Cart Part # Note: Extron products using the Universal AC Outlet accept a number of different AC plug types. Before use, ensure that the device meets all regulatory requirements for your region and complies with all applicable local safety and electrical codes and standards. Qty 1-9999 Current Total: Continue Shopping View Cart Item was added to Cart CTR 8


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March 1, 2014
Recap | Final Stats | Photo Gallery
Virginia Head Coach Julie Myers
"I can tell you, I am pretty excited! I thought we were going to do it with some comfort. It is kind of nice when your back is against the wall to actually come up. I thought Liza's last draw was huge, but she had so many huge moments in the game. Her teammates really did a nice job supporting one another. We definitely make it harder than it needs to be, but the nice thing is we are there to bail each other out."
On what she said in the timeout in the final two minutes
Composure. Take a deep breath. Composure. We've got possession of the ball. Everybody identified who was wide open and then we went with a totally different option when we went back to Liz. I didn't remember hearing that Liz was the free option, but you know what. We were able to spread the field. Everybody made the catches and made the plays and kept possession at the end of the game, so that was really nice to see."
On Penn State's goalkeeper Emi Smith
"I think she played great. I think we had a tendency of making her look better than she maybe she is, but I give her credit. She kept her stick in the right spots. It is easy to miss the easy saves. She certainly made the easy saves. I think our shooting was better in that second half, but it clearly needs to get much better."
On building confidence going into next week's North Carolina game
"It gives us a huge, deep breath. And a happy, relaxed day where we are proud of what we have done. Tomorrow we will regroup and get back at it, getting ready for Carolina starting Monday. I think we may have a couple of obstacles with this weather, but we are going to have to block that out as noise and we are going to pay no attention to it. Now it is just us focusing on Carolina."
Senior Liza Blue
On the win
"Winning has never felt so good."
On getting good shots in the second half
"That's what we practiced this week, just moving the ball quickly and find the open girl. We had a lot of shots, we just didn't finish them in the first half. I think in the second half, we smoothed out the kinks."
UVA Athletics Information
In the NewsRecent Headlines News Archives
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Cavalier Football NotebookFootball7/27/16The start of training camp is approaching for UVA's football team, which opens the season Sept. 3 against Richmond at Scott Stadium.Culture Change Under Way for UVA FootballFootball7/21/16Head coach Bronco Mendenhall, center Jackson Matteo and linebacker Micah Kiser represented Virginia at the ACC Football Kickoff on Thursday.Turner Embraces New Challenge at UVAMen's Lacrosse7/18/16Former UVA men's lacrosse standout Kip Turner is back at his alma mater as an assistant on new head coach Lars Tiffany's staff.
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A 1985 graduate of UVA, White worked at the Richmond Times-Dispatch until July 2009. He was honored six times as the state's Sportswriter of the Year.
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Three Players Named to ACC Women's Lacrosse All-Academ...
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Three Virginia women's lacrosse players were named to the ACC All-Academic Team, the league...
Four Virginia Women's Lacrosse Players Named to All-State Team
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Virginia's Season Ends with Loss to Johns Hopkins in NCAA...
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Four Players Earn IWLCA All-South Region Honors
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Virginia Plays Johns Hopkins Friday in NCAA First Round
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Jeff White: Preas Leads From Back for Cavaliers
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Second-team All-ACC pick Maggie Preas is a starting defender for UVA, which meets Johns Hopkins...
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- ITV Report
- ITV Report
Police arrest four after 'firebomb' attack
Live updates
- ITV Report
Faulty electric wiring fire unearths cannabis farm
Large-scale cannabis farm is being investigated in Anfield after reports of an arson on MondayRead the full story ›
- ITV Report
Appeal for witnesses following rape in Anfield
Detectives are appealing for witnesses to come forward after a 23-year-old woman was raped in Anfield last night - Sunday, 20 December 2015Read the full story ›
- ITV Report
Police track down target of Anfield school shooting
Detectives have found the man whose car was targeted by a gunman outside an Anfield primary school.Read the full story ›
Anfield shooting: Primary school day continuing as normal
Anfield Road Primary School has issued a statement following reports of gunfire outside the school on Tuesday morning.
Police are investigating the incident which happened while parents were dropping their children off at the school around 9am.
We would like to reassure people that our children are safe and were unaware of the incident that happened outside of the school site this morning.
The site was not evacuated, the school day is continuing as normal and a trip for some pupils took place as planned.
Due to the closure of the road for the police investigation we will be letting parents know about a change in arrangements to pick up their children at home time.
- ITV Report
Police appeal after Anfield Road shooting
Merseyside Police has issued an appeal for information after shots were fired outside a primary school on Anfield Road on Tuesday morning.Read the full story ›
Liverpool shooting: Police investigate reports of gunfire on Anfield Road
Police in Merseyside are investigating reports of a shooting in Anfield on Tuesday morning, November 24.
Officers were called to Anfield Road at around 9am after a shot was reportedly fired at a car.
The incident is believed to have happened outside Anfield County Primary School, near the junction with Walton Breck Road.
Detectives are carrying out enquiries at the scene. Police patrols have been stepped up in the area to reassure members of the community.
Witnesses are asked to call the gun crime hotline on 0800 230 0600 or Crimestoppers on 0800 555 111.
Search underway at Anfield for missing man who could still be in ground
Merseyside Police have confirmed a search of Anfield football stadium is currently underway after Liverpool Football Club raised an alert earlier this afternoon.
At 3.05pm the club reported to Merseyside Police that the ground had been evacuated after a man who had been on a tour was unaccounted for and believed to be in the stadium.
The club say they cannot guarantee the man has left the ground and therefore a search of the ground is underway.
Anfield evacuated as two men go missing during tour
Liverpool's Anfield stadium has been evacuated after two men went missing while going round the stadium on tour.
There have been local reports of a bomb scare and other tourists have been evacuated. Many had to leave their cars behind and are unsure whether the stadium will re-open tonight.
Sorry, this content isn't available on your device.
WATCH: new time-lapse of Anfield re-development
Liverpool FC has released new time-lapse footage capturing Anfield's transformation since work began on the redevelopment of the Main Stand.
The footage shows how the expansion has taken shape since construction work got underway in January and includes key moments such as the lifting of the new 650 tonne roof truss and the installation of the first concrete sections of the new upper tier.
Towering high above the existing Stadium, the redeveloped Main Stand is set to comprise three tiers, adding around 8,500 seats and taking the overall capacity of Anfield to around 54,000.
With more than 3,000 tonnes of steel already erected at Anfield, the Main Stand expansion project is scheduled to be completed during the 2016/17 season – creating one of the largest single stands in European football.
- ITV Report
O'Driscoll set to help Rodgers at Anfield
England Under-19 manager Sean O'Driscoll is set to join Liverpool boss Brendan Rodgers' coaching staff at Anfield.Read the full story ›


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gas cleaning Companies in New Jersey
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Kraft Power Corporation
Office in Pompton Plains, NEW JERSEY (USA)
Kraft Power Corp is a leader in the field of generator power systems, combined heat and power (CHP), power transmission products, diesel and gas engines and generator sets, as well as service, parts and accessories.
Hamon USA
based in Somerville, NEW JERSEY (USA)
Hamon USA formed a licence relationship with Research-Cottrell. Cooling Towers established as a Hamon company. Finally, in 1998, Hamon acquired Research-Cottrell and Custodis. Hamon has been providing a broad range of environmental and energy saving technologies to serve power and industrial applications. Hamon`s Mission is to provide high quality, innovative solutions ...
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Trace Environmental Systems, Inc. distinguishes itself by providing monitoring solutions in addition to a full range of support services. Trace Environmental is a supplier of Continuous Emissions Monitoring Systems (CEMS), Data Acquisition and Reporting Software (DAS 2000), and Environmental Data Base Management Systems. Trace Environmental provides monitoring systems, ...
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based in Pennington, NEW JERSEY (USA)
Ocean Power Technologies (OPT) is a leading renewable energy company specializing in cost-effective, advanced, and environmentally sound offshore wave power technology. The electrical power generated by OPT`s technology is key to meeting the energy needs of utilities, independent power producers and the public sector.


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Related quotes
"It takes longer to rebuild the image than it took to destroy it so they have to make sure that the facelift version of the E-Class is of a higher quality standard and more failure-safe than the pre-facelift version has been."
"The happiness of too many days is often destroyed by trying to accomplish too much in one day. We would do well to follow a common rule for our daily lives - DO LESS, AND DO IT BETTER."
"But thus shall ye deal with them; ye shall destroy their altars, and break down their images, and cut down their groves, and burn their graven images with fire."
"We just got destroyed on the backboards. Then we panicked and took some bad shots. It was just one of those nights where everything went wrong in the first five or six minutes."
"Whatever Frances didn't destroy, Jeanne took apart. We stripped the hotel down to the concrete structure."


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Star Trek Beyond
The Star Wars-ification of Star Trek continues; better than the others, but still not good enough.
The Star Wars-ification of Star Trek continues; better than the others, but still not good enough.
It's almost as if the writers were simply using ideas left over from other Ice Age scripts that are about as fresh as the wind…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Ken Loach's "I, Daniel Blake" wins the Palme d'Or at the 69th Cannes Film Festival.
Barbara Scharres on the cats of Cannes 2016.
Wednesday, July 18, is the 20th anniversary of our marriage. How can I begin to tell you about Chaz? She fills my horizon, she is…
This movie is trying to kill these women, but they endure.
Writers at RogerEbert.com pick their favorite movies featuring star-crossed lovers.
Writers at RogerEbert.com pick their favorite movies featuring aliens and UFOs.
A report from SDCC on an actor who has been in all three of the new "Star Trek" films. Well, sorta.
A report from the SDCC presentation of Oliver Stone's "Snowden."
Our Far-Flung Correspondents are cinephiles from all over the world, hand-picked by Roger Ebert to write about movies from their unique international perspectives. They include contributors from (alphabetically) Brazil, Canada, Egypt, Great Britain, India, Mexico, the Philippines, South Korea, Turkey and the U.S. They converge every year at Ebertfest.
I truly enjoy Mel Gibson's work as a director. His films, whether he stars in them or not, always reflect a passion and heart like few others. His best work these days, more and more, seems to be coming from behind the camera. It seems to me he really makes the movies for himself first and second for everybody else, no test audience previews to influence the final product.
"Apocalypto" is a film about the demise of the Mayan civilization. It tells the story of Jaguar Paw, whose small village is attacked by a group of hunters from the nearby metropolis, their job literally being to pillage small defenseless groups while looking for "volunteers" for their "most dangerous game": the sacrificing rituals that the city's leaders use to keep the masses entertained.
But unlike just about all of his peers, Jaguar Paw has been able to have his family spared by leaving them "holed up" in a most precarious situation. Will he be in time to save them before a pack of very angry suitors (or the jungle itself) stops him? Can a civilization like this, technologically advanced (relatively speaking of course) but rotten in its core, go on forever?
"Apocalypto" can be questioned for being graphically and brutally violent It can also be criticized for having the audacity to portrait what seems like a seven foot Mayan in a race of extremely short people; it can even be called out of not being historically accurate, after all, the Mayans were long gone when the Spanish arrived in present day Mexico during the 16th. century. I believe these feel like a foreigner's version of such events but nonetheless, this is also a beautiful looking, emotional and incredibly exciting film which at times makes "The Last of the Mohicans" seem passive in comparison. Besides, as Roger has said many times before, movies are probably not the best place to learn about historical facts.
"Apocalypto" was shot in an epic scale on a real jungle, with real size sets and mostly real animals, but it's the little details that stick with us: the ruthless warriors who fear nothing except for the sick, ominous, little girl; the meeting eyes from an old woman and the son-in-law whose life she once made more than a little difficult, but that now can only show pity for his upcoming, tragic faith; the happy and rich overweight kid enjoying his front row position to view barbaric events acting as if his rich dad had just gotten him free tickets on the fifty yard line.
Perhaps the main reason for which a lot of people may have skipped "Apocalypto" is the fact that it is spoken in a dead language and was cast with total unknowns. Was Gibson right to make these choices? Absolutely. Nor only would the movie have sounded ridiculous in any modern language but these possibilities allow us to feel when the credits roll, that we actually attended the events depicted here, what some call "the fly on the wall" theory.
For me, "Apocalypto" represents the opportunity to finally witness on the screen one of my country's ancient cultures after so many years of being thought about them in history books as a child. All those lessons about the inner workings of these societies are so much easily absorbed when they are depicted on a screen as well as they are here.
If you're tired of watching the same action movie over and over again and you've never seen "Apocalypto", I heartily recommend that you do. Please keep in mind this is a film that could be described as an "anti-chick-flick", in other words, it may be a bit more appealing for men than for women, (at least based on the reaction of the audience I shared my theatrical viewing with). Also beware if violent scenes make you squeamish (you may want to skip the candy counter this time around). Otherwise you're in for a great cinematic experience.
Next Article: Waiting and waiting for Godot Previous Article: Tony is troubled as you can get:The villains of "Iron Man 2"
This movie is trying to kill these women, but they endure.
A Blu-ray review of "Batman v Superman: Dawn of Justice (Ultimate Edition)," arriving July 19.
A compilation of reviews defending the new "Ghostbusters" film.
The new "Ghostbusters" film brings a battle between distorted nostalgia and the power of a child's imagination.


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Fire and Ice
Over the next three days, renowned glass artists Karen Willenbrink and Jasen Johnsen will be teaching folks the techniques necessary to create works in this challenging medium. And while glass artistry is a skill set most of us will never develop, it's easy to appreciate the process, as it is truly dramatic. People interested in all things glass will be able to meet with the visiting artists, who travel worldwide teaching the craft, at this special pre-workshop reception. The husband-and-wife team specializes in glass owls and tree branches that are startling in their minute detail and realism. During the party, guests will be invited to enjoy wood-fired pizza while watching a glass-art demonstration onsite.
Fri., Jan. 13, 8-10 p.m., 2012
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It is right on the street overlooking the harbor. All six of us had drinks and they bring you free appetizers
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It is right on the street overlooking the harbor. All six of us had drinks and they bring you free appetizers
We really enjoyed our lunch here. My husband really liked the tourist menu--which was great value and lots of food. He had fried fish, pesto pasta and a dessert. I had a very nice local fish. Staff was friendly. It was a good find.
We called here most evenings before dinner where drinks were served either at the bar or at a few allocated tables at the entrance of their restaurant. Staff were easy going and measures of spirits very generous. The café seemed very popular with locals and from the boating fraternity. It's position is ideal - right across from the waterfront and... 更多
Old established cafe/restaurant on promenade near harbour. Popular with locals early evening before tables near entrance are laid for dining. Whilst we did not eat here our party of 4 often called here for a nightcap which were incredibly good value. Very generous spirit measures often evidenced and an example would be 4 coffees, 6 Sambuccas, a brandy and a... 更多
We went here because it was crowded and we were on our way back from dinner. Wanted to see why. We had wine, cappuccino and dessert. Great food and great service in a warm and inviting atmosphere. Wish we had a dinner there, since what was coming out of the kitchen looked great and smelled even better. We will go... 更多
After a huge walk around the town we settle here for lunch was super busy and staff ignored us at the start ..so walk around side alley went in only to find it was the same restaurant. Ended up having delicious lunch served by a uninterested waiter ! Try the Veal and great house white wine !
This place is huge !!! You have to stop here ! This is the best place to eat Italian Girls are nice ! Prices are smooth ... All good !
We arrived late for lunch after being turned away elsewhere but got a good welcome. Nothing special inside but the food was good....seafood and pasta as good as places twice the price....also a reasonable selection of wines. Well worth a visit.
I ordered spaghetti in a tomato sauce- simple but so tasty. The restaurant lacks some charm and could easily be improved by removing some of the fridges that look like vending machines in the back room! Service was ok rather than good.
The service, the food, the atmosphere was top notch here. You could do breakfast, lunch and dinner here and feel like you're eating somewhere new each time. Easy our favourite spot in S.M! Thank you!
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Combined analysis of 2 genome-wide association studies in cases enriched for family history recently identified 7 loci (on 1p13.3, 1q41, 2q36.3, 6q25.1, 9p21, 10q11.21, and 15q22.33) that may affect risk of coronary artery disease (CAD). Apart from the 9p21 locus, the other loci await substantive replication. Furthermore, the effect of these loci on CAD risk in a broader range of individuals remains to be determined.
We undertook association analysis of single nucleotide polymorphisms at each locus with CAD risk in 11 550 cases and 11 205 controls from 9 European studies. The 9p21.3 locus showed unequivocal association (rs1333049, combined odds ratio [OR]=1.20, 95% CI [1.16 to 1.25], probability value=2.81×10−21). We also confirmed association signals at 1p13.3 (rs599839, OR=1.13 [1.08 to 1.19], P=1.44×10−7), 1q41 (rs3008621, OR=1.10 [1.04 to 1.17], P=1.02×10−3), and 10q11.21 (rs501120, OR=1.11 [1.05 to 1.18], P=4.34×10−4). The associations with 6q25.1 (rs6922269, P=0.020) and 2q36.3 (rs2943634, P=0.032) were borderline and not statistically significant after correction for multiple testing. The 15q22.33 locus did not replicate. The 10q11.21 locus showed a possible sex interaction (P=0.015), with a significant effect in women (OR=1.29 [1.15 to 1.45], P=1.86×10−5) but not men (OR=1.03 [0.96 to 1.11], P=0.387). There were no other strong interactions of any of the loci with other traditional risk factors. The loci at 9p21, 1p13.3, 2q36.3, and 10q11.21 acted independently and cumulatively increased CAD risk by 15% (12% to 18%), per additional risk allele.
The findings provide strong evidence for association between at least 4 genetic loci and CAD risk. Cumulatively, these novel loci have a significant impact on risk of CAD at least in European populations.
Coronary artery disease (CAD), and its main complication, myocardial infarction (MI), have a significant genetic basis. Until recently, attempts at identifying genetic variants that affect risk of these common diseases have been hampered by poor reproducibility of associations and limited coverage of the genome.1 However, well-powered genome-wide association (GWA) studies have now identified several novel putative loci that increase risk of CAD and MI.2–5 Specifically, combined analysis of the Wellcome Trust Case Control Consortium (WTCCC) and the German MI Family GWA studies identified 7 chromosomal loci (on 1p13.3, 1q41, 2q36.3, 6.q25.1, 9p21.3, 10q11.21, and 15q22.33), all of which showed highly significant associations with CAD.5 The locus on chromosome 9p21.3 was also identified in 2 other GWA studies3,4 and has since been associated with CAD, stroke, as well as abdominal aortic and intracranial aneurysms in several other cohorts.6–8 The locus on chromosome 1p13.3 was recently shown to also be strongly associated with LDL cholesterol concentration,9-13 reinforcing the close mechanistic association between the variability in LDL levels and CAD risk. Beyond these initial studies on the loci at 9p21.3 and 1p13.3, the reproducibility of the association with CAD risk of the other loci identified by GWA studies has not yet been studied systematically.
Many of the exploratory GWA studies were carried out on patients with a high genetic burden of the disease. For example, both the WTCCC and German MI Family Study analyzed cases enriched for a positive family history of CAD.5 Here, in one of the largest molecular-genetic experiments on CAD, we report the replication analysis of the 7 principal loci for CAD identified thus far in GWA studies,2-5 in a broader group of CAD patients, explore their interactions with traditional risk factors, and assess their cumulative impact on CAD risk.
We investigated participants recruited into 9 separate studies in Europe with validated cases of CAD and appropriate controls: the Academic Medical Center Amsterdam Premature Atherosclerosis Study (AMC-PAS), the Etude Cas-Témoins sur l'infarctus du Myocarde Study (ECTIM), the European Prospective Investigation into Cancer and Nutrition Study (EPIC-Norfolk), the German MI Family Study (GerMIFS; only including subjects that did not overlap with the original GWA Study), the Cooperative Health Research in the Region of Augsburg Study (KORA/GOC), the Ludwigshafen Risk and Cardiovascular Health Study (LURIC), the MORGAM Study, which has harmonized data from prospective follow-up of population cohorts in several countries, the Population-based northern German cross-sectional study (PopGen), and the UKMI Study. Almost all of these participants were of white Northern European origin. Details of the recruitment process in each study and references for each study are provided in the supplemental materials (available online at http://atvb.ahajournals.org). For the chromosome 9p21.3 locus some of the study groups (GerMIFS, KORA/GOC, PopGen, and UKMI) overlap with a previous publication on this locus.6 In addition, the MORGAM Study has recently reported an analysis of the association of the novel loci with disease history and risk factors at baseline, and CAD and stroke events and death during follow-up in their prospective cohorts.14
Common criteria for CAD and MI were applied across all the studies and required validated evidence for the phenotype (see supplemental materials). Cases not meeting these criteria were excluded. Similarly, uniform criteria were defined for partitioning of participants for risk factors (see supplemental materials). Those individuals where the information was unavailable or could not be assigned according to the criteria were classified as missing for the variable.
For the 7 loci (1p13.3, 1q41, 2q36.3, 6.q25.1, 9p21.3, 10q11.21, 15q22.33), we selected the SNP showing the strongest association with CAD in the previous GWA analysis (lead SNP).5 In addition, we selected SNP rs10738610 in the 9p21.3 locus which had shown marginally stronger association in a fine mapping experiment using HapMap SNPs,6 and SNP rs2972147 in the 2q36.3 locus which is a proxy for rs2943634. Finally, linkage disequilibrium analysis of the 7 loci in HapMap identified that in 3 of them, there were subsets of highly correlated SNPs (r2>0.8) significantly associated with CAD/MI which were not in the haplotype block defined by the lead SNP. The most significant SNP in each of these secondary haplotype blocks was also selected for genotyping giving a total of 13 SNPs (supplemental Table I and supplemental Figure I).
Genotyping was carried out with the iPLEX assay (Sequenom) for all SNPs except rs599839 and rs2943634, which were assayed by TaqMan (Applied Biosystems) using standard protocols (assays details available by request from the authors). iPLEX genotyping was performed at the Wellcome Trust Sanger Institute in Cambridge, UK, for all studies apart from MORGAM which was genotyped at the National Public Health Institute, Helsinki, Finland (Sequenom assay) and INSERM Unit 525, Paris France (TaqMan assays).
Analysis was performed in Stata (Stata Statistical Software Release 10, 2007, StataCorp LP). Each study was analyzed separately by unconditional logistic regression using an additive genetic model (ie, genotype codes 0, 1, 2) adjusting for center in studies involving multiple sites. Heterogeneity between the studies was tested using Cochran Q chi-squared test, and the size of the heterogeneity was measured using the I2 statistic. Only one nonlead SNP showed strong between-study heterogeneity (see supplemental Table III). Consequently, the odds ratios (OR) for the studies were meta-analyzed under a fixed effect model. Bonferroni correction was used to adjust for the number of SNPs tested. The analysis was performed for CAD cases and then for the subset of MI cases. The assumption of an additive model was assessed in the whole dataset by comparing the fit of that model with the fit of a 2-degree of freedom pairwise comparison in a likelihood ratio test. To assess the overall strength of the association of novel loci with CAD risk, probability values from the present analysis were combined with those from the GWA studies5 using Fisher method, both with and without adjusting the original GWAs findings for multiple comparisons using the Bonferroni method. All tests were 2-sided.
To investigate whether there was any interaction between a locus and relevant demographic characteristics or cardiovascular risk factors (age, sex, body mass index, hypertension, smoking, and diabetes) participants were divided into 2 groups on the basis of the particular covariate. The analysis for CAD was repeated on the appropriate selection of patients in the same way as for the full study, and then the results were combined into a single forest plot.
Independent effects of the associated loci were verified by including them all in a single logistic regression. Cumulative risk was assessed by forming a score based on the total number of risk alleles across 4 or 6 loci (see Results). The case/control status was then compared with the number of risk alleles in a logistic regression analysis adjusting for study and center within study. The number of risk alleles was considered both as a categorical measure and as a continuous measure in a trend test.
Power calculations were performed by simulation. Data were generated to represent studies of the same numbers of cases and controls as in the actual replication study using an additive model with a given common odds ratio and allele frequency and assuming Hardy-Weinberg equilibrium (HWE). Analysis was by logistic regression and then meta-analysis as in the main study. The number of individual studies that were significant at the 5% level was counted and whether the combined result was significant was noted. Each set of simulations was repeated 1000 times.
The characteristics of the pooled case and control participants from the 9 European studies are shown in Table 1. Additionally, the characteristics of participants in each study individually are shown in supplemental Table II. Altogether, 22 755 participants (11 550 cases and 11 205 controls) underwent genotyping from these studies. As anticipated, the prevalence of established cardiovascular risk factors was higher in CAD cases than in controls (Table 1). Of the CAD cases, 6831 (59.1%) had a confirmed history of MI and the mean age of cases at first event was 59.5 (std. dev. 10.0) years.
Genotypes in excess of 90% were obtained for all SNPs, and there was no difference in the proportion of successful genotypes between cases and controls (supplemental Table I). None of the SNPs showed significant deviation from HWE. Nominally significant association (P<0.05) with CAD was observed at 6 of the 7 chromosomal loci studied (Table 2). For all loci, except for chromosome 1q41, the lead SNP identified in the GWA studies5 showed the strongest association among the genotyped SNPs (supplemental Table III). Moreover, in all instances the same allele as in the previous study showed the increased risk with CAD. Interestingly, for 1q41, no significant association was seen for the previously reported lead SNP (rs17465637; supplemental Table III); however, a SNP (rs3008621) in an adjacent haplotype block showed a significant association (Table 2). The strength of the association ranged from an OR of 1.20 (95% CI: 1.16 to 1.25) for the 9p21 locus (rs1333049, P=1.63×10−21) to an OR of 1.05 (1.00 to 1.09) for the locus at 2q36.3 (rs2943634, P=0.03) and 1.05 (1.01 to 1.10) for the locus at 6q25.1 (rs6922269 P=0.02). The associations for the loci at 2q36.3 and 6q25.1 were not statistically significant after Bonferroni correction for the number of SNPs tested (Table 2). We found no evidence for association with the locus at 15q22.33 (Table 2). The associations in the subset of cases with MI largely paralleled those seen for CAD (Table 2).
To examine the totality of our evidence of association for each locus, we also combined the association results from the present studies with those from the 2 original GWA studies.5 The signals for the 6 loci that showed nominally significant association in the present study became stronger in a meta-analysis that included these prior studies, even after correction for multiple testing in the GWA studies (supplemental Table IV). There was no evidence of nonadditivity for any of the loci assessed (ie, better fit using a dominant or recessive model: supplemental Table V).
There was no significant heterogeneity in the magnitude of the associations of the loci between the pooled studies (Table 2). However, as expected from the power calculations (see Methods and supplemental Table VI), associations were not individually significant in every study (findings for each study by locus are shown in supplemental Figure II).
We also investigated whether there was any interaction between the effect of the loci and a number of prespecified characteristics or risk factors, namely age, sex, BMI, hypertension, diabetes mellitus, and smoking on risk of CAD. The analyses are displayed in supplemental Figure III. Note that the analyses for the risk factors are limited because only demographic information (age and sex) was available from 3 of the control groups (supplemental Table II). The most notable finding was that the magnitude of the association of the locus on 10q11.21 with CAD was greater (P=0.015 for interaction) in women (OR=1.29 [1.15 to 1.45], P=1.86×10−5) compared with men (OR=1.03 [0.96 to 1.11], P=0.387). There was also a suggestion that the effect of the locus on 1q41 was only present in older subjects and that the effect of the chromosome 9p21 locus was stronger in women and weaker in the presence of hypertension. However, neither of these interactions was significant (P>0.05), and otherwise the association of the loci with CAD appeared largely independent of anthropometric characteristics and risk factors (supplemental Figure III).
The proportions of cases and controls carrying different number of copies of the risk alleles for the 4 most strongly associated loci (1p13.3, 1q41, 9p21, and 10q11.21) are shown in the Figure. There is a significant rightward shift in the number of risk alleles carried by cases (P<0.0001). Because of the high prevalence of these alleles, the majority of these European white individuals carry more than 5 out of a possible 8 alleles (Figure). To investigate the cumulative risk associated with carriage of multiple risk alleles, we estimated the ORs in individuals carrying different numbers of the risk alleles for these loci. The 4 loci act independently with a combined OR of 1.15 (1.12 to 1.18) per additional risk allele. Because of the sex-specific effect of the locus on 10q11.21, the OR per additional risk allele was higher in women (1.21 [1.15 to 1.27]) compared with men (1.12 [1.08 to 1.16]). There was no significant interaction with age (P=0.30).
In this study we describe a large scale evaluation of novel loci for CAD identified through previous GWA studies.5 In addition to the 9p21 locus, which has already been robustly replicated in several other studies,2,3,6–8 we provide compelling evidence for the association of at least 3 further loci (1p13.3, 1q41, and 10q11.21) with CAD risk. Nominal associations (P<0.05) were observed for 2 further loci, those at 2q36.3 and 6q25.1, but these became statistically nonsignificant after correction for the number of variants examined.
The increase in risk among the loci ranged from 5% to 20% per copy of the risk allele. These are less than those we found in the GWA studies (20% to 37%).5 There are perhaps two main reasons for this. First, the GWA studies were carried out in relatively young cases enriched for a genetic tendency for CAD (each case had to have at least one first degree relative affected with CAD) which may have enhanced the genetic effect. Second, primary association findings by their nature tend to often be more inflated than the true degree of association. Thus, some degree of "the winner's curse" was to be expected.15 Our present analysis was carried out in a much wider range of individuals with CAD, better reflecting the disease spectrum with regard to age of onset as well as relevant comorbidities and thus likely to provide a more reliable estimate of the association of each locus with CAD risk in general populations. Although individually the effect of carrying each risk allele is relatively modest, their importance in terms of contribution to the development of CAD and the public health needs to also take into account the prevalence of the risk alleles which range from 26% to 87% (Table 2). Thus, most European individuals carry multiple risk alleles (Figure).
Our study emphasizes the scale of endeavor required to quantify reliably the modest effect sizes which are typically being found for loci detected using GWA approaches for complex traits. Even with a combined sample size of more than 22 000 European participants, we only had sufficient (>80%) power to detect OR >1.05 across a range of allele frequencies (supplemental Table VI); hence the evidence of association for 2 of the loci (those at 2q36.3 and 6q25.1) remains inconclusive. Furthermore, simulations showed that even under the most favorable scenario, that pertaining to the locus at 9p21 with an OR of 1.20 and an allele frequency approaching 0.5, a "true" effect would not have been expected to be observed in each of the individual studies. Indeed, for the sizes of the studies involved here, the proportion of positive studies we observed for each locus was largely consistent with what might have been expected for "true" effects (supplemental Table VI). These findings are therefore remarkable in that we were able to detect a definite association with at least four of the initial 7 loci that emerged from the GWA studies in populations based in geographically and culturally different parts of Europe. This suggests that further loci with similar effect sizes await discovery in even larger analyses. Although we cannot rule out important gene–gene or gene–environment effects, our findings suggest that the loci identified affect CAD risk under a wide range of circumstances. This is also consistent with the lack of significant interactions with demographic parameters or other cardiovascular risk factors except for the locus on chromosome 10q11.21 (see below).
Our study does not identify the precise causal variant(s) at each locus. This will require resequencing of the entire recombination interval for each locus in a large set of chromosomes enriched for the risk allele to define the full spectrum of variants followed by fine mapping of the association signal. The finding at the locus on chromosome 1q41 emphasizes the importance of this work. We confirmed an association not with the GWA lead SNP but a related SNP suggesting that both markers are in linkage disequilibrium (LD) with the causal variant(s) at this locus but the strength of pair-wise LD differs.
So what are the implications of the present findings? The role in disease prediction often dominates discussion of such findings. Our analysis shows that although, cumulatively, carriage of increasing number of risk alleles imparts substantial additional risk (eg, carriage of seven risk alleles versus 4 risk alleles increases risk on average by 52%), genetic testing for the 4 most strongly replicated loci is unlikely to be sufficiently discriminatory to identify people likely to develop CAD (Figure). This lack of discriminatory capability is very similar to that seen for genetic loci underlying other complex traits such as diabetes16 as well as with other cardiovascular risk factors (eg, plasma cholesterol level)17 and consistent with theoretical considerations.18 Potentially a more immediate and realistic clinical application of the findings could be to help identify people at increased coronary risk so that primary preventive measures, eg, cholesterol lowering, could be directed to those at highest genetic risk. This stratification could theoretically be carried out from a relatively young age, as DNA analysis can be done at any stage from birth. However, whether such testing is clinically beneficial and cost-effective requires much further investigation.
Perhaps, the greatest utility of these findings will come from understanding the mechanisms and pathways by which the loci affect CAD risk as this could provide new targets for drug development. The genes located within each locus (Table 3) have not been previously implicated in the pathogenesis of CAD. Recently, for the locus at 1p13.3, the same allele of SNP rs599839 that is associated with increased CAD risk, has been shown to be associated with higher plasma total and LDL cholesterol in multiple studies,9-13 providing a possible explanation for the effect on CAD risk, although even for it the precise mechanism by which the locus affects LDL cholesterol and the gene(s) involved awaits elucidation.19 The 9p21 locus shows a region of association coincident with a gene for a noncoding RNA, ANRIL.20 Such RNAs often play a regulatory role in gene expression or translation. There is preliminary evidence that ANRIL may affect the expression of the adjacent cyclin-dependent kinase inhibitors,20 which in turn could affect vascular remodeling processes which are important in the pathogenesis of atherosclerosis and its complications. The association signal at 1q41 lies within the melanoma inhibitory activity family, member 3 (MIA3) gene, which may play a similar role in cell growth or inhibition.21 The locus at 10q11.21 lies upstream of the CXCL12 gene which codes for stromal cell-derived factor-1 (SDF-1), a chemokine which plays a key role in stem-cell homing and tissue regeneration in ischemic cardiomyopathy22 and in promoting angiogenesis through recruitment of endothelial progenitor cells.23 Altogether, the findings open up the prospect of novel therapies for CAD, which may be broadly applicable, from a better understanding of the pathogenic mechanisms in the vascular wall affected by these loci.
Women are less prone to CAD than men, which could partly be attributable to differences in gene–environment interactions. Interestingly, the locus on chromosome 10q11.21 showed a stronger association in women than in men. The nature of the locus with CXCL12 as the most proximate gene (Table 3) does not suggest an immediate mechanism that could explain a gender interaction and whether this finding, which was of borderline statistical significance and would not have been significant if we had adjusted for the multiple interaction analyses carried out, represents a true sex difference in effect requires further investigation. Apart from this, we did not find any other striking interactions, although it should be noted that the lack of data on some risk factors for three control populations means that our ability to detect such interactions was constrained and further investigation in a larger sample is necessary.
In summary, through a large scale replication study we provide compelling evidence for the association of at least 4 genetic loci and risk for CAD. The findings provide a strong foundation for further investigation of these loci as risk factors for CAD and their potential value in the treatment and prevention of this common condition.
We thank the participants and staff in each of the studies who contributed to the present article. We particularly thank Siv Knaappila and Minttu Jussila for technical support in MORGAM. We thank members of the MORGAM Management Group who are not coauthors: Stefan Blankenberg, Marco Ferrario, Leena Peltonen, Markus Perola, Denis Shields, Hugh Tunstall-Pedoe, and Kjell Asplund.
Sources of Funding: Data and sample collation and genotyping were funded by the EU Integrated Project Cardiogenics and also supported by the Wellcome Trust. The GerMIFS Study was partly funded through the German Federal Ministry of Education and Research (BMBF) in the context of the German National Genome Research Network (NGFN-2 and NGFN-plus). The MORGAM study was partly funded through the European Community's Seventh Framework Programme ENGAGE project (grant agreement HEALTH-F4-2007-201413), the Center of Excellence in Complex Disease Genetics of the Academy of Finland (CoECDG), and Finnish Foundation for Cardiovascular Research. N.J.S. holds a Chair supported by the British Heart Foundation.
Philippe Amouyel, Dominique Arveiler, S. Matthijs Boekholdt, Peter Braund, Petra Bruse, Suzannah J. Bumpstead, Peter Bugert, Francois Cambien, John Danesh, Panos Deloukas, Angela Doering, Pierre Ducimetière, Ruth M. Dunn, Nour-Eddine El Mokhtari, Jeanette Erdmann, Alun Evans, Phil Ewels, Jean Ferrières, Marcus Fischer, Philippe Frossard, Stephen Garner, Christian Gieger, Mohammed J.R. Gohri, Alison H. Goodall, Anika Großhennig, Alistair Hall, Rob Hardwick, Ari Haukijärvi, Christian Hengstenberg, Thomas Illig, Juha Karvanen, John Kastelein, Frank Kee, Kay-Tee Khaw, Harald Klüter, Inke R. König, Kari Kuulasmaa, Paivi Laiho, Gérald Luc, Winfried März, Ralph McGinnis, William McLaren, Christa Meisinger, Caroline Morrison, Xiodan Ou, Willem H. Ouwehand, Michael Preuss, Carole Proust, Radhi Ravindrarajah, Wilfried Renner, Kate Rice, Jean-Bernard Ruidavets, Danish Saleheen, Veikko Salomaa, Nilesh J. Samani, Manjinder S. Sandhu, Arne S. Schäfer, Michael Scholz, Stefan Schreiber, Heribert Schunkert, Kaisa Silander, Ravi Singh, Nicole Soranzo, Klaus Stark, Birgitta Stegmayr, Jonathan Stephens, John Thompson, Laurence Tiret, Mieke D. Trip, Ellen van der Schoot, Jarmo Virtamo, Nicholas J. Wareham, H-Erich Wichmann, Per-Gunnar Wiklund, Ben Wright, Andreas Ziegler, Jaap-Jan Zwaginga
H. Schunkert (Cochair), N.J. Samani (Cochair), F. Cambien, J. Danesh, P. Deloukas, J. Erdmann, A. Evans, A. Hall, C. Hengstenberg, K. Kuulasmaa, R. McGinnis, W.H. Ouwehand, D. Saleheen, M. Scholz, J. Thompson, A. Ziegler
N.J. Samani (Chair), P. Deloukas, J. Erdmann, C. Hengstenberg, K. Kuulasmaa, R. McGinnis, H. Schunkert, N. Soranzo, J. Thompson, L.Tiret, A. Ziegler
R. McGinnis (Cochair), J. Thompson (Cochair), A. Ziegler (Cochair), M. Fischer, C. Gieger, A. Großhennig, I.R. König, J. Karvanen, W. McLaren, M. Preuss, M. Scholz, N. Soranzo, L. Tiret, B. Wright
J. Erdmann (Cochair), N. Soranzo (Cochair), P. Braund, P. Bruse, S.J. Bumpstead, P. Deloukas, R.M. Dunn, P. Ewels, S. Garner, R. Hardwick, A. Haukijärvi, M.J.R. Ghori, J. Karvanen, K. Kuulasmaa, P. Laiho, R. McGinnis, W. McLaren, W. März, X. Ou, W.H. Ouwehand, C. Proust, R. Ravindrarajah, K. Rice, D. Saleheen, M. Sandhu, A.S. Schäfer, M. Scholz, K. Silander, J. Stephens, L. Tiret, M.D. Trip
AMC-PAS: M.D. Trip, J. Kastelein
SANQUIN controls: E. van der Schoot, J.-J. Zwaginga
ECTIM: D. Arveiler, F. Cambien, A. Evans, F. Kee, G. Luc, C. Morrison, J.-B. Ruidavets
EPIC-Norfolk: M.S. Sandhu, N.J. Wareham, S.M. Boekholdt, K.-T. Khaw
GerMIFS: J. Erdmann, H. Schunkert, C. Hengstenberg
KORA/GOC: M. Fischer, C. Hengstenberg, K. Stark, C. Meisinger,
KORA S4 controls: T. Illig, A. Doering, H.-Erich Wichmann, C. Gieger
LURIC: W. März, W. Renner
German Blood Service (GerBS) controls: P. Bugert, H. Klüter
MORGAM: V. Salomaa, J. Virtamo, P. Amouyel, B. Stegmayr, A. Evans, K. Kuulasmaa, L. Tiret, J. Karvanen, K. Silander, P. Laiho, A. Haukijärvi, C. Proust, D. Arveiler, J. Ferrières, P. Ducimetière, P.-G. Wiklund
PopGen: A.S. Schäfer, N.-E. El Mokhtari, S. Schreiber
UKMI: N.J. Samani, P. Braund, R. Singh, A.H. Goodall
Pasteur Institute, Lille, France (P.A.); Department of Epidemiology and Public Health, Louis Pasteur University, Strasbourg, France (D.A.); Academic Medical Center, University of Amsterdam, The Netherlands (S.M.B., J. Kastelein, M.D.T.); Department of Cardiovascular Sciences, University of Leicester, UK (P. Braund, A.H.G., R.H., N.J.S., R.S.); Medizinische Klinik II, Universität zu Lübeck, Germany (P. Bruse, J.E., H.S.); The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK (S.J.B., P. Deloukas, R.M.D., P.E., M.J.R.G., R.M., W. McLaren, X.O., R.R., K.R., N.S.); Institute of Transfusion Medicine and Immunology, University of Heidelberg, Mannheim, Germany (P. Bugert, H.K.); INSERM UMR_S 525, UPMC Univ. Paris, France (F.C., C.P., L.T.); Department of Public Health and Primary Care, University of Cambridge, UK (J.D., K.-T.K. D.S., M.S.S.); Institute of Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany (A.D., C.G., T.I., C. Meisinger, H.-E.W.); IFR69 INSERM-Paris XI University, Paris, France (P. Ducimetière); Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, Kiel, Germany (N.-E.E.M., A.S.S., S.S.); Queens University Belfast, Northern Ireland (A.E., F.K.); INSERM 558, Department of Epidemiology, Paul Sabatier-Toulouse Purpan University, Toulouse, France (J.F.); Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Germany (M.F., C.H., K. Stark); Aga Khan University, Karachi, Pakistan (P.F., D.S.); Department of Hematology, University of Cambridge, UK (S.G., W.H.O., J.S.); Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Germany (A.G., I.R.K., M.P., A.Z.); LIGHT, University of Leeds, UK (A. Hall); National Public Health Institute (KTL), Helsinki, Finland (A. Haukijärvi, J. Karvanen, K.K., P.L., V.S., K. Silander, J.V.); INSERM U508, MONICA Lille, Service d'Epidémiologie et de Santé Publique, Institut Pasteur, Lille, France (G.L.); Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Austria (W. März, W.R.); The MONICA Project, Glasgow Royal Infirmary, Scotland, UK (C. Morrison); INSERM U518, Faculté de Médecine, MONICA Toulouse, France (J.-B.R.); Trium Analysis Online GmbH, Munich, Germany (M.S.); FIMM, Institute for Molecular Medicine Finland, Helsinki (P.L., K. Silander); Twin Genetic Epidemiology, King's College London, UK (N.S.); Umeå University Hospital, Umeå, Sweden (B.S., P.-G.W.); Department of Health Sciences and Genetics, University of Leicester, UK (J.T., B.W.); Department of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands (E.v.d.S., J.J.Z.); MRC Epidemiology Unit, Cambridge, UK (N.J.W.).
Disclosures: None.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
I have a 2000 Grand Voyager. Popcorn popping sound is coming from the front end when the van
is in motion. I've changed the sway bar links and bushing, checked the brakes. What else could it be?
We have 142K miles on it. Regular maintanance.
Thursday, March 1st, 2007 AT 3:32 PM


text:
Portabella Pizzeria opens in Port Washington
Portabella Pizzeria & Restaurant in Port Washington is in its third week of serving sandwiches, pastas and other entrées as well as pizzas.
Owner Izzo Jonuzi said he hopes to add 15 tables outside for summer to supplement the 55 seats inside at Portabella, at 218 E. Washington St. »Read Full Blog Post(1)
Bar owners scramble to keep up with fake ID technology
The arms race between bar owners and college students with increasingly sophisticated fake IDs is heating up.
Students today can spend $100 to $150 on fake identification through a number of websites that claim superior quality down to the holograms and bar codes. There's an underground review that rates the quality of fake IDs from different sites. Students can even watch YouTube videos on how to make IDs showing they're 21, the legal drinking age. »Read Full Article(30)
The Dirty Heads' Jared Watson talks about Landing Their Big Gig
Jared Watson, left, of hip-hop-flavored reggae band the Dirty Heads, performing in the Tap Milwaukee studios last month. Watson talked to Tap about landing his first big at the famed Roxy in Los Angeles. Photo by Bill Schulz. »Read Full Blog Post


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Web spam is an attempt to increase rank of inappropriate web pages. Link spam is one of web spam technique which aims for increasing rank by creating artificial popularity of the page by increasing in-links of the page. This task required creating a lot of boosting pages which is a page spammer created for boosting rank of spam page. In this paper, we proposed a technique to detect web spam based on finding these boosting pages instead of web spam page itself. We start from a small set of spam seed pages to find boosting pages. Then web spam pages will be detected using boosting pages. Moreover, we evaluate normal pages to increased the preciseness of our algorithm. Experimental result shows that most of spam pages can be retrieved. Moreover, accuracy of our algorithm can be increased by normal pages analysis.
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Written on: 18/03/2013 by BLB12345 (1 review written)
Upc is terrible! I would never recommend it to any one. After I pause a program it constantly freezes. When I change Chanel or want to go to guide or dvr it takes for ever! Especially on demand that takes much longer. UPC am have really good deals but trust me it is definitely not worth it! Before I got UPC I had sky I wish I had never changed to UPC!
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A website with examples of how Iowa and the country benefit from teaching, research and extension efforts at Iowa State University and the nation's other land-grant universities has been launched.
John Lawrence has been reappointed to a second five-year term as associate dean for extension in Iowa State University's College of Agriculture and Life Sciences and director for agriculture and natural resources for Iowa State University Extension and Outreach.
Crop producers can continue discussions about the Iowa Nutrient Reduction strategy and local watershed improvement, learn more about best practices for reducing nutrient loss into Iowa's waterways, and talk to farmers who are implementing practices at upcoming events.


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Authority Could Be Catalyst Development Travel Destinations
Authority Could Be Catalyst Development Travel Destinations – Proposed establishment of the Tourism Authority initiated by Tourism Minister Arief Yahya support. The presence of observers assessed the agency's marine and tourism economy, Prof. Arif Satria could break the ice in the area of tourism development.
"When basically not in the interests of regional destinations, the agency can indeed overlap (overlapp) with the presence of Kemenpar. But when konsennya to the destination area, the agency that I believe will make a tremendous akselesari to the development of regional tourism, "said Dean of the Faculty of Human Ecology (FEMA), Bogor Agricultural University (IPB) that in his statement on Sunday (10/1).
Arif fully supports the establishment of the tourism authority body to boost the advancement of various tourism destinations are selected. Initially, Arif had thought that the establishment of the agency is not based on the interests of regional destinations.
Menurutdia, which is often a problem in the development of tourism is a bureaucratic machine. He likened, not a bureaucratic machine-engined Ferrari, but old-fashioned truck engine. Therefore, he said, the development process bottlenecks are in the infrastructure at tourist destinations are often apprehensive.
"With this body, it should be all it can be cleared as soon as possible. Provided that the agency is committed to staying focused destination and prioritize infrastructure, "said Arif. He said he is optimistic that the agency would be a catalyst for the development of tourist destinations in various regions in Indonesia.
Arif warned, Tourism Authority Board should prioritize regional tourist destinations located in areas that are considered less bureaucracy has the ability to develop tourist destinations quickly.
"If I may suggestion, the two regions may be prioritized addressed this body, the Raja Ampat and Komodo. If developed sincerely and systematically, Raja Ampat has a great chance to outperform the Maldives (Maldives), "said Arif.
Discourse of the establishment of the Tourism Authority expressed Menpar Arief Yahya in coordination meeting Follow Tourism Zone Management Authority of Lake Toba in Toba Samosir, North Sumatra, on Saturday (9/1). Menpar explain the importance of the Tourism Authority Board for Indonesian tourism.
He cited the case of the tourist area of Lake Toba managed seven districts around Indonesia's biggest lake. "Imagine, the company has seven CEO, his company was not able to walk," said Arief Yahya.
Tourism Authority Board is a body formed Kemenpar, containing experts, local and national governments. Tourism Authority Board would have the job to decide on strategic issues in the tourism area.
This was done so that all matters of tourism can be resolved quickly and easily through a single door. "Tourism Authority Board no later we leave and have to be approved by President Jokowi. Looking ahead, there are 10 featured destinations are being readied his authority bodies, "said Menpar outbound garut