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Clinical-Style Validation, Regulation, and Quality Control...
Co-Sourcing Improves Pharmaceutical Laboratory Productivity
Loss of Lives in Clinical Trials...
Researchers Now Have a Myriad of...
Trevena raised $35 million in a Series B round of financing with all its existing investors. The firm says the funds will be used for Phase II trials with its lead heart failure drug TRV120027 and to progress its pipeline of GPCR-biased ligands.
"This financing will allow us to demonstrate clinical proof of concept for TRV120027, the first biased ligand dosed in human clinical trials, and to advance our pain and inflammation programs through discovery and into the clinic," comments Maxine Gowen, Ph.D., the firm's president and CEO. "Despite the success of GPCR-targeted drugs to date, there is huge scope to enhance the therapeutic properties of these molecules through more targeted signaling."
TRV120027 is an angiotensin II type I receptor (AT1R) β-arrestin biased ligand in development for the treatment of acute heart failure.
Trevena is exploiting a drug-discovery platform designed to uncover and differentiate between biological pathways eliciting beneficial and deleterious effects of a target GPCR and then identify a biased ligand that targets only the pathways associated with beneficial effects. The firm claims that in contrast with current GPCR-targeting approaches that tend to activate and deactivate all related signaling pathways, its biased-ligand approach enables the precise targeting and activation/deactivation of specific signaling pathways, resulting in potentially more effective and safer drugs. The approach also provides new insights into novel GPCR biology and could help address targets that would otherwise be difficult to address, the firm adds.
Trevena's technology hinges on its Advanced Biased Ligand Explorer (ABLE™), platform, which comprises a set of integrated tools for identifying and characterizing functionally selective biased ligands for a wide range of GPCRs. The platform includes customized assays, proprietary software, animal models, and biological signaling information across multiple GPCRs.
TRV120027 is the firm's lead compound and the first to start in clinical development. Additional preclinical-stage candidates include lead optimization-stage candidates for the treatment of pain. Targets in the fields of inflammation and oncology supportive care have also been identified.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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10 October 2013 at 2:20 AM
Lena Dunham Milks a Cow for 'Billy on the Street'!
About this photo set: Lena Dunham dons a colorful top while being interviewed on Fuse's Billy on the Street on Wednesday (October 9) in New York City. The 27-year-old Girls actress… Read More Here
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NT01 Summer / Track Tires by Nitto®. This car tire is a DOT-compliant dry competition radial designed with the weekend road racer in mind. The compound was developed to provide the best balance of traction, consistency, heat cycle performance and longevity. The NT01 delivers fast and consistent lap times for both the professional road-racer and the track-day enthusiast. The NT01 is recommended for dry competition use.
- Increased lateral and forward traction
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By incorporating computer-modeled designs for road noise reduction and a program that aids in enhancing dynamic contact points while driving, Nitto's engineers successfully identify and counteract undesirable responses of the tires in a variety of driving conditions. In addition, the tested technological advances in polymer tread compounds allow their engineers to deliver truly high-quality Nitto tires that provide extended tread life, improved traction on both wet and dry roads and inspire driver satisfaction.
Founded in 1979, Nitto is driven by passion and innovation. They create tires for those who are enthusiastic about their vehicles. The company always strives to anticipate and drive consumer trends by supporting emerging markets before they are mainstream, helping them grow and driving the market forward. Nitto's tire sizing, tread patterns and tire compounds combine modern aesthetics with cutting-edge technology. This philosophy has helped them create some of the most radical-looking tire designs available on the market today. These memorable designs are the result of state-of-the-art development, quality engineering and rigorous testing procedures.


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RUSHMORE is the story of a gifted, rebellious teenager named Max Fischer (Jason Schwartzman), a 10th grader at elite Rushmore Academy. Editor of the school newspaper, captain or president of innumerable clubs and societies, Max is also one of the worst students in the school, and the threat of expulsion hangs permanently over his head. Max's world is rocked when he falls for elegant 1st grade teacher Miss Cross (Olivia Williams) and he plans to erect an aquarium in her honor -- then finds himself competing for her affections with his friend, steel tycoon Mr. Blume (Bill Murray), the wealthy father of two of his classmates.
Wes Anderson's follow-up to the quirky Bottle Rocket is a wonderfully unorthodox coming-of-age story that ranks with Harold and Maude and The Graduate in the pantheon of timeless cult classics. Jason Schwartzman (son of Talia Shire and nephew of Francis Coppola) stars as Max Fischer, a 15-year-old attending the prestigious Rushmore Academy on scholarship, where he's failing all of his classes but is the superstar of the school's extracurricular activities (head of the drama club, the beekeeper club, the fencing club...). Possessing boundless confidence and chutzpah, as well as an aura of authority he seems to have been born with, Max finds two unlikely soulmates in his permutations at Rushmore: industrial magnate and Rushmore alumnus Herman Blume (Bill Murray) and first-grade teacher Rosemary Cross (Olivia Williams). His alliance with Blume and crush on Miss Cross, however, are thrown out of kilter by his expulsion from Rushmore, and a budding romance between the two adults that threatens Max's own designs on the lovely schoolteacher.
Never stooping to sentimentality or schmaltz, Anderson and cowriter Owen Wilson have fashioned a wickedly intelligent and wildly funny tale of young adulthood that hits all the right notes in its mix of melancholy and optimism. As played by Schwartzman, Max is both immediately endearing and ferociously irritating: smarter than all the adults around him, with little sense of his shortcomings, he's an unstoppable dynamo who commands grudging respect despite his outlandish projects (including a school play about Vietnam). Murray, as the tycoon who determinedly wages war with Max for the affections of Miss Cross, is a revelation of middle-aged resignation. Disgusted with his family, his life, and himself, he's turned around by both Max's antagonism and Miss Cross's love. Williams is equally affecting as the teacher who still carries a torch for her dead husband, and the superb supporting cast also includes Seymour Cassel as Max's barber father, Brian Cox as the frustrated headmaster of Rushmore, and a hilarious Mason Gamble as Max's young charge. Put this one on your shelf of modern masterpieces. --Mark EnglehartSee all Product Description
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filmmaking voice, after his very promising debut with 'Bottle Rocket'.
Quite simply one of the most original films about adolescence ever
made. An unlikely love triangle between a unique oddly brilliant 'cool geek'
teenager, his teacher and a local business tycoon that's
simultaneously funny, absurd and heartbreaking.
Jason Schwartzman is great, and Bill Murray may do his best work ever -
side-splittingly funny, but with a damaged, sad, sometimes dangerous
edge just under the surface.
As in all of Anderson's films, terrific use of songs as score,
wonderfully inventive transitions and visual framing. And a lot of fun.
The Criterion version has notably better
picture quality, and some terrific extras (the regular release is
pretty bare bones). It's more expensive, but worth it for a film
you're likely to return to repeatedly.
Max Fisher (Jason Schwartzman) is a high school student. He goes to Rushmore. He has it all figured out - he is an average student at best, but his extra-curricular activities can not be contained. He's the president, or founder, or director to almost every single group, club or association in the school, ranging from calligraphy and debate to sword fighting and go-kart racing. And, most of all, he's the head of the Max Fisher Players theater troup.
He meets Herman Blume (Bill Murray), a tired, depressed man who happens to be a millionaire . He has two annoying sons who go to school with Max. They hit it off and become friends - Max finds someone to look up to (other than his barber dad) and Blume finds someone that sparks the interest he lacks for everything else in life.
Enter Miss Cross (Olivia Williams). Max falls in love with her at first sight, but of course, she pays no attention to him, so he recruits Mr. Blume to help him win her, but in the process, he too falls in love with the teacher. What follows is a hilarious battle of wits between the two as both try to get the other out of the way.
Although this story alone would make a good movie, Anderson's writing and directing take this film to the next level.Read more ›
Like Tenenbaums, Rushmore is a film about vulnerable people finding their way through conflict to resolution and reconciliation. From my Christian point of view, I like to see it as GRACE. In the world of Rushmore, there is even hope for a washed-up old failure like tycoon Herman Blume (Bill Murray).
The filmmakers place in their world characters who are poles apart from one another: Rich and poor; English, Scottish and American; young and old; western and eastern. Somehow events conspire to show the characters their commonality; something breaks; and through the cracks we see glimpses of healing.
Performances are incredible. I have never been a fan of Murray, but after this, I can see myself fast becoming a devotee. Schwartzman veers brilliantly between suavely sophisticated and grimacingly geeky. Seymour Cassel is a talent I would like to see more of: His brief appearances here and in Tenenbaums are to be treasured. There is even an amusing turn from Mason Gamble, who doesn't seem to have aged a bit since Dennis the Menace.
The humour is subtle, yet hilarious to those with whom this brand of quirkiness resonates. For me, its funniness comes from the fact that the comedy is not arbitrary---no banana skins for banana skins' sake---but is made part and parcel of the characters, who they are and how they develop.Read more ›
Most recent customer reviews
Le dvd était en parfait état, tel que décrit. Je suis très satisfaite. Il est arrivé rapidement et était très bien emballé.Published on Dec 21 2012 by joannie lavoie
The owner of the video store warned us about this movie - it only appeals to a certain segment of the population, he told us. He was right. Read morePublished on June 15 2004 by J. Jacobs
I never truly understood the point of the whole film, but it was different. I'll give props to the kid in movie who tried so hard to make something great out of something... Read morePublished on May 28 2004
Max is a dedicated student, putting effort into all after school activies. However his world is turned upside down by the arrival of a new female teacher. Read morePublished on April 27 2004 by Lucy W
Rushmore might be the best dark comody of all time and is really just weird.I believe it is some kid who is named Max and he is best friends with a rich millionaire (Murray) and he... Read morePublished on April 16 2004 by Chris
I love this movie and if it were a person I would marry that person because I would love tha tperson equally to how much I love this movie which would be a lot which would explain... Read morePublished on April 10 2004 by ...


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20:04 26th December 2013
Late Goal Sees Off Plucky Alex
Wolves 2 (Jacobs 3, Griffiths 90+2)
Crewe Alexandra 0
It took a stoppage time goal from substitute Leigh Griffiths to confirm Wolves' victory over a plucky Crewe Alexandra side after Michael Jacobs had scored his first goal for the club in the opening minutes.
Kenny Jackett made three changes to his starting X1 with Kevin McDonald, back from suspension, Michael Jacobs and Cassidy coming in and replacing Björn Sigurdarson, Bakary Sako and Kevin Doyle.
Wolves kicked-off attacking the North Bank end and they were ahead as the game moved into the third minute. Cassidy played Scott Golbourne in on the overlap and his cross was met by Jacobs whose bullet header left Alex keeper Ben Garratt with no chance.
Crewe responded with a free-kick from Harry Davis that was headed goalwards by visiting skipper Abdul Osman but Carl Ikeme didn't have to move his feet to save.
James Henry comprehensively beat Kelvin Mellor as he took the ball to the bye-line and Garratt did well to cut out the winger's low, driven centre.
Cassidy tried his luck with an overhead kick following a Henry corner but the ball struck a defender and bounced away from goal before being scrambled clear.
Jack Price was way too high with a shot from fully 30-yards out before a good save from Ikeme prevented a 27th minute equaliser from Alex. George Evans lifted over a corner and Chuks Aneke, with a bouncing header, brought the best out of the Wolves keeper.
Seconds later a Price cross hit Osman and fell to Danny Batth and the defender looked odds on to score. But the ball struck the base of the left hand upright before bouncing into the path of Henry whose goalbound follow up was deflected behind off Mellor for a fruitless corner.
Another good Crewe opportunity was thwarted by Ikeme who turned aside an Aneke drive with Osman running into an offside position as he followed up.
Jacobs went into the book for a foul on Byron Moore and, after a Mark Ellis header flew across goal and bounced behind off Osman at the far post, Evans was also yellow carded after a late challenge on McDonald.
Half-Time: Wolves 1 Crewe 0
In the opening attack of the new half, Cassidy took the ball down the right flank and fired over the near angle.
Then Ikeme pulled off a terrific save from Tom Hitchcock who had run onto Aneke's through ball and was clean through on goal. Then Golbourne limped from the field to be replaced by Ethan Ebanks-Landell. Shortly afterwards there was another Wolves change with Griffiths taking the place of Dave Edwards.
Cassidy was making his presence felt on the opposition defence and after Garratt had saved a low drive from outside the box, another effort from the Welsh striker hit a defender and looped up in the air falling to Ebanks-Landell who, faced with three defenders, could only lob the ball onto the roof of the net.
Garratt made a routine stop to hold on to a Jacobs shot but then the keeper made an outstanding save as he palmed a Griffiths header against the underside if the bar after Henry had supplied the cross.
Batth forced the ball home after another Henry cross but the referee deemed that Richard Stearman had fouled the keeper. At the other end Davis was high and wide with a 25-yrad free-kick after Ebanks-Landell had been pulled up for a challenge on Moore.
Henry and Griffiths were wide and high with respective goal attempts and when the pair combined shortly afterwards, a defender block Henry's path to goal.
In the 89th minute the home support held its breath as a shot from Crewe substitute A-Jay Leitch-Smith seemed to take an age before it drifted narrowly wide of the far post.
But, as the game drifted into stoppage time, Griffiths eased the tension and he ran onto a pass from Henry and checked before slamming a left-foot drive past Garratt from the edge of the box (pictured).
Wolves: Ikeme, Golbourne (Ebanks-Landell 56), Ricketts (capt), McDonald, Batth, Stearman, Henry, Edwards (Griffiths 59), Cassidy (Doyle 90+2), Price, Jacobs.
Unused subs: Hennessey, Sako, Evans, McAlindon.
Booking: Jacobs (40 – foul)
Alex: Garratt, Tootle, Mellor, Davis, Ellis, Osman (capt), Moore (Leitch-Smith 85), Hitchcock (Inman 74), Evans (Grant 74), Aneke, Bangna
Unused subs: Martin, Ray, Guthrie, Oliver.
Booking: Evans (42 – foul).
Referee: S. Attwell.
Attendance: 22,693.
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Madison, WIUSA
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I'd like to talk with a broader array of people about the way they see themselves in relation to Earth.
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In 2008 there was actually a "pray for Ron Paul" website and I was impressed. I do pray for many things and I was moved today to seek out a new RP prayer site. There is not one at present; I propose to rename my other blog Conflicted Libertarian to Pray for Ron Paul 2012 if there is enough interest in it (I cannot change the URL but can change the title) and the goal is to have a Prayer Bomb for Ron Paul – have people ready to pray every day for the campaign, the candidate and his family and for success.
The Lord of Hosts is able to give victory! Let's pray for Ron Paul!


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EMU Puts 82 On ODAC All-Academic Team July 27, 2016 Another successful year of competition has been matched with another successful year in the classroom for EMU's student athletes. The Royals... [full story]
Six Royals Earn Academic All-State Status July 25, 2016 Six EMU student-athletes have been named to the Academic All-State Team by VaSID. A total of 234 student-athletes representing 41 colleges and... [full story]
Bryan Takes Over Lead Of EMU Running And Track Programs July 18, 2016 Eastern Mennonite University has announced that Isaac Bryan will take over as the new Director of Cross Country and Track & Field and Head... [full story]
Softball Women Put Three On All-State Team June 21, 2016 EMU's softball team stuck another stamp on a historic season, putting Mariah Foltz, Angelia Miller and Carli Hill on the All-State Team. [full story]
Eberly Steps Down From EMU Golf Programs June 27, 2016 Eastern Mennonite University has announced the resignation of head golf coach Wendell Eberly. The resignation is effective June 30. [full story]


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Press releases
McMahon Family Purchases Embryo Package for $20,000 to Benefit Hereford Youth
KANSAS CITY, Mo. — Hereford enthusiasts once again came together to support the youth Jan. 13 in the Beef Palace Auction Arena during the National Western Stock Show in Denver. Belle Point Ranch and the Dave and Mary Ann McMahon family of Ft. Smith, Ark., generously supported the Hereford Youth Foundation (HYFA) by purchasing the embryo package for $20,000. All of the proceeds go to HYFA.
With the purchase of Lot 1, Belle Point and the McMahons have acquired six exciting matings, 20 embryos in all, and some of the top Hereford genetics in the country.
These generous donors contributed to the embryo package:
Sunset Ridge Herefords, Billy Martin, Cumming, Ga.
Mill Creek Ranch/Pied Piper Farms, Alma, Kan., and Hamlin, Texas
Jensen Bros., Kevin and Shelia, Courtland, Kan.
Topp Herefords, Ryan and Prairie Topp, Grace City, N.D.
Fawcett's Elm Creek Ranch, Keith and Cheryl, Daniel and Kari, Ree Heights, S.D.
Through the years Belle Point Ranch and the McMahon family have been very supportive of Hereford youth. They also purchased the 2010 HYFA Foundation Female.
"Since 2008, Lot 1 has generated nearly $250,000, and it is very rewarding to have donors like Belle Point Ranch step up time and again in support of the Foundation," says Amy Cowan, HYFA director. "The Dave and Mary Ann McMahon family, as well as the embryo donors for this year's package lot, are to be commended for their continuous support of our Hereford youth program."
The Hereford Youth Foundation of America is a 501 (c) 3 not-for-profit. Its mission is to support scholarship, education and leadership activities within the Hereford breed. For more information about the HYFA contact the AHA at 816-842-3757 or visit HerefordYouthFoundation.org.
- Hereford Juniors Compete in National Contests
- New Junior Hereford Board Members, Officers Elected
- Braman, Effling, Lowderman, Skiles Take Owned Female Show Honors at 2016 Junior National Hereford Expo
- Matheny Named Hereford Junior Herdsman of the Year
- Matheny Named Hereford Junior Herdsman of the Year
- Jones Named Hereford Advisor of the Year


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« previous Page 151 of 259 next »
Looking for a few simple ways to freshen up the go-to dish of the Super Bowl? We cobbled together a mighty tasty basic guacamole, then came up with four ways to turn basic into unbelievably good.
Entrepreneurs will hear from one of the top economic development officials in the state at the All Things Money Conference set for Wednesday, Jan. 30. The program will be held at East Mississippi Community College's Douglas Building Lyceum from 8:30 a.m. to 12:30 p.m.
Genealogist and author Thomas Locke Mayfield will give a book talk on his newest book, "Whispers from Columbus Past: Stories from the Past that You Should Know" on Monday, Jan. 28, at the Columbus-Lowndes Public Library from 2-3 p.m.
Technology offers ways to improve wedding experiences for guests and connect friends and family who could not attend.
On Thursday, the Mississippi Film Office celebrated its 40th anniversary with a special birthday cake celebration in the rotunda of the Mississippi State Capitol. Gov. Phil Bryant signed a proclamation declaring Jan. 17 as "Mississippi Film Day." The state boasts one of the five oldest film commissions in the world.
The exhibit "Looking Back at Gee's Bend: The Photographs of John Reese, 1980" is currently on display at the Chebie G. Bateman building of the Columbus-Lowndes Public Library.
When funny, mold-looking things start growing on landscape trees and shrubs, phones start ringing in Mississippi State University Extension Service offices across the state.
'Downton Abbey," the acclaimed British drama brought to American audiences on PBS, is indeed a masterpiece which has taken the world by storm with its Edwardian setting and dramatic tensions both above and below the backstairs. The early 1900's era is revisited through all the grandeur of Edwardian fashion, even down to the romanticism of hairstyling and makeup.
Sometimes it seems that we are surrounded by people who were raised by animals. The "bull headed," the "greedy pigs," the "sly foxes" are all around us. "Personification" and "anthropomorphism" -- we employ these concepts every day. They are shortcut explanations -- easy to understand, but usually not literal.
The Gordy Honors College Forum series opens Thursday, Jan. 24 at 6 p.m. at Nissan Auditorium in Parkinson Hall on the campus of Mississippi University for Women. The Forum Series continues through April presenting lectures, film and undergraduate research.
With many states -- including Mississippi -- reporting high levels of flu-like illnesses, those who've avoided it so far can take steps to protect against the flu's onslaught. Even if you've had the flu this season, there still are steps you should take, said a nurse practitioner educator at Mississippi University for Women.
Angela Brown is a force. Whether stunning international opera audiences in roles like "Aida," singing show-stopping art songs in concert, or winning over school children with her inspired program, "Opera from a Sistah's Point of View," Angela Brown is a charming, witty, formidable force.
I know. Believe me, I get the irony of featuring cheesy recipes the week after 300-calorie dishes filled our food pages, but Sunday is National Cheese Lovers Day -- and man does not live by calorie-counting alone.
The Rev. Tony Montgomery of Columbus checks his watch a lot these days. He has numerous places to be and tasks to check off, as do Learnard Dickerson and Lavonne Harris, who complete the trio of lead organizers of Dream 365.
Steady rain on a gray Wednesday didn't dampen spirits inside a music room at Joe Cook Elementary Fine Arts Magnet School in Columbus. Fifth-graders concentrated, drawing bows across strings as they performed a scale on violins for their music teacher, Tina Morgan. As the last notes faded, the children's faces were wreathed in smiles.
When we last saw the fictional Jake Crosby, he and his daughter, Katy, had narrowly survived a harrowing nightmare in the Alabama woods, hunted by drug runner Moon Pie Daniels and his band of thugs. Jake, a stockbroker and hunter, was forced to kill two of his pursuers. Moon Pie had vowed revenge.
« previous Page 151 of 259 next »
1. Go crackers: An artisan baker's ingenuity opens new doors FOOD
2. Anne's Kitchen: From a Southern kitchen FOOD
3. Scrambled eggs baked in muffin tins make mornings easier FOOD
4. Cooking on deadline: Asian beef-and-mushroom burgers FOOD


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Gamma RZR Bubba 117 Tennis Racquet
Select 2 Day Racquet Shipping at checkout.
Gamma RZR racquets utilize Advanced Aerodynamics, with unique geometric contoured shapes designed to deflect and streamline airflow around the frame. Rounded radius surfaces, Tapered Bridge Beam, and Low Profile Bumper allow the RZR beam to easily channel airflow around the frame regardless of attack angle. M Carbon composite matrix increases strength at key points on the frame for optimal power transfer.
- Headsize: 117 sq. in.
- Length: 27.25 in.
- Weight (strung): 9.50 oz.
- Stiffness (Babolat RDC): 65
- Balance: 14.40 in. Head Heavy
- Cross Section: 22/24/22mm Tapered Beam
- Swingweight: 405 kg*sq. cm
- String Pattern: 16x19
- Grip:Gamma RZR Tac
- Overall Rating: 5.0 / 5.0
- Write a Review
Tried a couple and I don't know why this is not more popular! Love the light weight of the frame and the large, but not too large head. Felt easier to swing than the Wilson 3 or the Head. Comfortable and powerful. They recommended some Gamma TNT and I like it so far. My doubles partner is happy now!!


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to moderately positive specific to Columbia Labs.
I simply disagree with any opinion to the contrary and the reason is as follows. The vast majority, if not all, small/micro cap bios that have implemented such a maneuver generally to always have one thing in common beyond the necessity to meet listing requirements and that something is that they all "burn cash".
Cash burners in distress that reverse split the outstanding common are essentially sounding a dinner is served bell for short sellers, hence the usually predictable post split fall for the recently elevated via manufactured PPS.
That is NOT the case for Columbia beginning with cash flow positive status and ending with cash on the balance sheet vs current MC against revenue generation Q/Q. In other words, the stock is very cheap now and will remain "identically" very cheap after a "potential" reverse split.
The moderately positive aspect is that the listing "overhang" will be "eliminated" with no ill effects to current shareholders.
Recent history and the corresponding effects on the share price can't be disputed but value still remains and risks are, for the most part, completely wrung out of the stock from a valuation standpoint.
Still standing by the original post "10 weeks earlier"!
The stock still remains under valued and the "predictable" RS PR makes/made perfect sense. For one thing, if an RS had the potential to negatively impact the PPS beyond current valuation, "management would certainly have delayed the process to the max" which could easily be well into CY '14 but they made the smart move to "expeditiously" remove the psychological overhang and divert focus back to the more relevant which is earnings.
Citimar is simply off his rocker if he thinks I care/cared (accumulated shares in .60 +or- area) about ancient CBRX history. It's all about valuation in the here and now, and that is all!
The measured rise to higher ground will continue for all with the patience to allow it to happen!
Pretty simple IMO!
they are freak shows bc they are burning cash. have no access to capital markets....none of which exist for cbrx....my recommendations short of some life to prochieve, is for frank to financially engineer this puppy. Give a dividend, do a buyback...we have cash and will continue to generate cash, and more of it as merck kga is dedicating themselves in the ART area. Reward the shareholders by un-diluting them from all the freak show secondaries of the past. Thats how you get the stock to recognize its value
topro, the dividend is a good idea imo, even if it has to be used in conjunction with a reverse split. I see no reason why a dividend could not be issued. Mgmt has been against the buyback because they say it will use up all the cash. OK, then do a dividend. This needs to be considered carefully by mgmt. We are cash positive for the foreseeable future, and it rewards longer term investment, while it may still allow for an acquisition utilizing some cash at some point. It also does not have to be issued if we enter into some lean qtrs. Mgmt needs to really look at this option.
Oh cut me a break. That analysis is the most ridiculous I've ever read. The stock is down 75% from the highs it reached at $4, a few years ago. THEY ARE REQUIRED TO SPLIT THE STOCK TO STAY ON THE EXCHANGE. Do you think they would do a reverse split if the DIDN'T have to? No. You know why. Because $10 stock (20 for one split) is much thinner than a $.60 stock. Many people with 1,000 shares now, will get out when they only have 50 shares and a thinner stock makes it easier for shorts to manipulate the stock. Some shorts CANNOT short a $.60 stock, but at $10, they will have a feast.
I guarantee you it goes lower. The only question is how much? I've had a number of these and have NEVER seen one go back to pre-split values!!!!!
Citamar, please calm down before you have a nervous breakdown or something!
Of course, barring positive news prior to, a reverse split appears to be the only option available to meet listing requirements. Is this comment supposed to be some genius revelation that no one considered before now? Of course not!
Where we totally disagree is the effect on the PPS "post split". Thats fine Citimar, you're entitled to an opinion. I just disagree with with what you think in this instance. I've been investing in the small and micro bio space for 2 decades and have witnessed PLENTY, so no need for you to try and "save me from myself"! I'll be just fine.
PS, if the small fry *(face it CIT most are already victims of attrition) throw in the towel,,,,SO WHAT! Their shares WILL be absorbed like tasty snacks. It's the holders of quantity that matter and I see nothing but shake-out/ accumulate at the bottom of the range for months now. Lastly, and you know full well, whether the the stock was 10, 20 or 100 at one time is irrelevant, the only thing that matters now is that the PPS is under the minimum PPS threshold set forth by the exchange. Again I say, SO WHAT! 54M MC now and 54M MC post split *(subject to change) Cheap vs cheap and NO green light for short sellers!
It's not life and death Cit, lighten up a little will you please!
usually correct cit..look at SRPT..was avii trading at 60c/sh last june..they reversed 6:1 last june..last july BOOM news hit and the stock has rallied from $3.6 to over $45 and is over $37 today..if the fundamentals are there it is possible to win at the reverse split game but you are correct reverse splits are usually done by freak show companies..


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realmagick.com The shrine of knowledge.
A selection of articles related to humulus.
Original articles from our library related to the Humulus. See Table of Contents for further available material (downloadable resources) on Humulus.
- Hops: Correspondences
- Humulus lupulus Folk Names: Beer Flower, Flores de Cerveza Gender: Masculine Planet: Mars Element: Air Deity: Power: Healing, Sleep...
Herbalism >> Herbs dictionary H
Humulus is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Humulus books and related discussion.
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- 6 Marijuana Facts You May Not Have Known — From Health Benefits to the Truly
- According to Popular Science, marijuana and hops – the flower commonly used to brew beer – share similar organoleptic properties of taste and smell. This is because Humulus lupulus (hops) and Cannabis sativa (marijuana) belong in the same botanical ...
- 7 Plants That Can Help with the Winter Doldrums
- Hops (Humulus lupulus)—Hops grow wild over most of the U.S. and were traditionally used by many tribes to make bread rise.
- 10 Terpenes Found in Cannabis
- One of the most appealing parts of cannabis is the scents and flavors associated with the various varieties of the plant. Organic compounds known as terpenes are produced by most plants as a defense against herbivores, who otherwise would consume them ...
- Brewing Experiment Yields 30 Brews in 30 Days
- With the expansion of hop breeding programs and widespread cultivation of Humulus lupulus, brewing has evolved to suit preferences of tasters around the world.
- Jamaican Cannabis Landraces: History and Importance
- There are only 2 genera in this family, the other one being Humulus (hops).
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Gaspar Hickes, (d. 1677) was a diligent, faithful, Reformed, Presbyterian minister of the Gospel and a member of the Westminster Assembly of Divines. This work is a collection of Gasper Hickes'... More > surviving sermons. His first sermon is on Isaiah 28:5-6, "In that day shall the Lord of hosts be for a crown of glory…for his people…." It is a powerful sermon demonstrating the presence and the favor of God as the glorious ornament of a godly person. The second sermon is on the advantage of having afflictions, based on Hosea 5:15, "In their affliction they will seek me early." God's people seek him early and earnestly in affliction. The last is on Acts 13:36, "For David...fell on sleep, and was laid unto his fathers, and saw corruption." It is exceedingly comfortable to the godly man, that he is the most useful serviceable creature that lives on earth. This is not a scan or facsimile, has been updated in modern English for easy reading and has an active table of contents for electronic versions.< Less
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UPDATE: Credit Suisse Raises PT on AmerisourceBergen Corp. on Multi-Year Growth Outlook
In a report published Thursday, Credit Suisse analyst Glen Santangelo reiterated an Outperform rating on AmerisourceBergen Corp. (NYSE: ABC), and raised the price target from $61.00 to $64.00.
In the report, Credit Suisse noted, "Despite the significant move in the shares YTD (~+31%), we continue to believe that ABC remains an attractive investment given the multi-year growth outlook created by the cumulative benefit of the WAG relationship. We believe investors have been too myopically focused on the $0.25 (gross) accretion contribution in F14 and are failing to fully appreciate the bigger (multi-year) picture, which has created a competitive advantage for ABC."
AmerisourceBergen Corp. closed on Wednesday at $56.55.
Latest Ratings for ABC
|Jun 2016
|Bank of America
|May 2016
|Avondale Partners
|Market Outperform
|Market Perform
|Apr 2016
|Avondale Partners
|Initiates Coverage on
|Market Outperform
View More Analyst Ratings for ABC
View the Latest Analyst Ratings
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© 2016 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.


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The first objective of the present study was to identify opportunities of improvement for clinical practice, assessed by local quality indicators, then to analyze possible reasons why we did not reach defined treatment quality measures. The second objective was to characterize patients, considered unresectable according to present criteria, for future arrangement of interventional studies with improved patient selection.
Prospective observational cohort study from October 2008 to December 2010 of patients referred to the authors' institution with suspected pancreatic or periampullary neoplasm.
Of 330 patients, 135 underwent surgery, 195 did not, 129 due to unresectable malignancies. The rest had benign lesions. Perioperative morbidity rate was 32.6%, mortality 0.7%. Radical resection (R0) was obtained in 23 (41.8%) of 55 patients operated for pancreatic adenocarcinoma and 6.3% underwent reconstructive vascular surgery. Diagnostic failure/delay resulted in unresectable carcinoma, primarily misconceived as serous cystic adenoma in two patients. One resected lesion turned out to be focal autoimmune pancreatitis. One case with misdiagnosed cancer was revised to be a pseudoaneurysm. Palliative treatment was offered to 144 patients with malignant tumors, 62 due to locally advanced disease and all pancreatic adenocarcinomas.
Quality improvement opportunities were identified for patient selection and surgical technique: Too few patients underwent reconstructive vascular surgery. The most important quality indicators are those securing resectional, radical (R0) surgery. Altogether 143 patients (57.9%) of those with malignant tumors were found unresectable, most of these patients are eligible for inclusion in future interventional studies with curative and/or palliative intention.
Pancreatic and periampullary malignancies represent specific diagnostic and therapeutic challenges and surgery is still the only treatment with curative potential. Despite this fact, surgical treatment is underutilized in the USA. The National Cancer Data Base (NCDB) recently reported that 38.2% of patients with early stage pancreatic cancer without any identifiable contraindications, failed to undergo surgery [1]. Considerable variability in outcome exists among hospitals performing pancreatectomies [2], but it is difficult to identify the factors responsible for this variation. The lack of standardized examination of resected specimens has been one important confounder of outcome evaluation, until a systematic, detailed technique for handling and evaluation of resected specimens with coloring of the resectional margins was introduced [3]. The International Study Group for Pancreatic Surgery (ISGPS) has developed objective, universally accepted definitions for complications after pancreatic surgery [4–6]. This cohort study was initiated after the implementation of all these standards. The first objective was to identify opportunities of improvement of the clinical practice, assessed by local quality indicators, then to analyze possible reasons why we did not reach defined treatment quality measures. The diagnostic and therapeutic algorithm was critically assessed, focusing on clinical consequences of surgery without preoperative histological diagnosis. Also intraoperative strategy and technique were critically assessed, with rate of R0 resections as end point. The performance of the authors' institution was finally evaluated against expert validated quality indicators [7], which has been developed by the American College of Surgeons' Pancreatic Cancer Quality Development (ACSPCQD).
The second objective was to characterize patients, considered unresectable according to present criteria, for future arrangement of interventional studies with improved patient selection. The concept that neoadjuvant chemoradiation might improve overall survival in patients with marginally respectable [8], or even clearly resectable pancreatic adenocarcinoma [9], is supported by several authors. But the benefit of an R1 resection, compared with no resection, also seems underestimated [10], and different treatment algorithms need prospective investigation.
In October 2008, Oslo University Hospital, Ullevaal (a tertiary referral center) established a multidisciplinary research program for patients undergoing investigation for a solid or cystic pancreatic or periampullary neoplasm. The program was approved by the Regional Ethical Committee for registration of clinical data in addition to sampling of blood, tumor tissue, cyst fluid and bone marrow for research purposes. The authors present clinical data for 330 consecutive patients (Figure 1), referred for evaluation by the multidisciplinary team. Data were prospectively collected from October 2008 to December 2010 after signed informed consent. Seventeen patients did not sign the consent and were excluded.
Standard evaluation included physical examination, routine laboratory tests, tumor markers (CEA, CA 19-9, chromogranin A) and contrast-enhanced helical computed tomography (CT) of the abdomen and thorax in three vascular phases. Tumors with infiltration of the celiac trunk or superior mesenteric artery and metastatic disease were considered unresectable [11]. Tumors with infiltration of the superior mesenteric vein (SMV) or portal vein (PV) were considered resectable if there was patent vein above and below the occlusion to allow interposition grafting [12–14]. Tumors were never considered borderline resectable, as international definitions of this concept were published during the inclusion period. Patients underwent laparotomy when presumed operable, the others referred for palliative chemotherapy, without later reassessment of resectability. Preoperative percutaneous biopsy/cytology was not performed in resectable patients because of the risk of tumor seeding [15]. Patients with cystic lesions underwent endoscopic ultrasound (EUS), and if possible, aspiration of cystic fluid for cytology and analyses of mucin, CEA and amylase.
All patients were presented at the weekly multidisciplinary pancreatic conference, attended by radiologist, hepato-pancreato-biliary (HPB) surgeon, gastroenterologist and oncologist. Neoplasms in the body or tail were preferably resected laparoscopically, lesions in the head with open pylorus preserving pancreaticoduodenectomy (PPPD). The relationship between the resection plane and the tumor was guided by intraoperative ultrasound in addition to direct vision during all laparoscopic procedures [16]. Intraoperative evaluation of indication/surgical approach for vascular resection/reconstruction was done in co-operation with the liver transplantation team or vascular surgeons. The pancreatic resectional margin was investigated intraoperatively by frozen sections. Total pancreatectomy was chosen only when mandatory to achieve negative resectional margins. Histological confirmation of the lesion was secured from the resected specimen in all operated patients. For those not operated, EUS or percutaneous biopsy/cytology was recommended in all cases, but some did not accept it. After documentation of malignant cytology or histology, unresectable patients were referred to the Department of Oncology for palliative chemotherapy and/or radiotherapy. Patients with pancreatic adenocarcinoma who underwent curative surgery, received adjuvant chemotherapy (leucovorin every second week for 6 months, according to the Nordic FLV regimen). Follow-up was performed with CT scan of the chest and abdomen every sixth month or if the patient had symptoms suspected of a recurrence.
All tumors were classified according to the TNM criteria of the AJCC (American Joint Committee on Cancer) 2010 cancer system [17]. The margin resection status (R-status) was defined according to the revised pathological specimen evaluation with inking of resection margins and R1 defined as a distance of the tumor from the resection margin of < 1 mm. The pathologist participated in the surgical procedure, marking every plane of resection, thereafter sectioning the specimen for final assessment of R-status.
Complications during the preoperative investigation in the authors' hospital or after surgery were recorded. ISGPS definitions of postoperative fistula (grade A–C) [4], delayed gastric emptying [5] and postoperative hemorrhage [6] were used. Grade C fistulas from the pancreaticojejunal anastomosis were treated by resection of the pancreatic remnant.
The diagnostic part of the algorithm included all guidelines described above: the whole patient cohort of patients with pancreatic and periampullary tumors underwent preoperative investigation, aiming at surgical resection as fast as possible, without percutaneous biopsy/cytology [18], and without neoadjuvant chemoradiation. The positive prediction of resectability, based on preoperative radiology, was required in at least 85%, based on previous experience and literature [19,20]. The maximum accepted interval from baseline to start of surgical treatment was set to 3 weeks, and maximum 4 weeks were accepted for investigation in advance of baseline.
During the inclusion period, a set of 43 quality indicators was published, developed and validated by the ACSPCQD Expert Panel [7]. These have been compared with the authors' local quality indicators and utilized to assess the performance of their institution. Finally, rating of clinical relevance and importance of all quality indicators has been performed, based on the present outcome data.
Values are given as median and range. Survival curves were illustrated as Kaplan–Meier plots. Survival differences between groups were analyzed with the Log rank test. The level of significance was set at p < 0.05.
The study population consisted of 330 consecutive patients seen in the multidisciplinary clinic, 165 (50%) men, 165 (50%) women, median age 66 years (range 21–86 years). In 135 patients (41%), a surgical procedure was performed. Resection of a malignant tumor was done in 100 patients, 20 (14.8%) underwent pancreatic resection of a benign lesion and 15 (11.1%) patients were found unresectable at laparotomy due to unrecognized metastases (n = 9) or a more locally advanced tumor (n = 6) than preoperatively expected (Figure 1). In 195 patients (59.1%), surgical treatment was not found indicated, 66 due to final benign diagnosis, 129 due to locally advanced (n = 56) or metastatic (n = 73) disease (Figure 1). Patient demographics, surgical procedures, R-status and TNM classification in the 100 patients who underwent resection of a malignant tumor are listed in Table I, 55 (52.9%) were resected for pancreatic adenocarcinoma. Whipple procedures or total pancreatectomies were performed in 95 patients, 6 of these (6.3%) combined with reconstructive vascular surgery. Operation time was median 295 min, range 181–480 min, median blood loss 855 ml, range 230–4000 ml and ASA (American Society of Anesthesiologists) score was median 2.0, range 1–3. R0 resection was achieved in only 41.8% of the pancreatic adenocarcinomas (Table I). The analysis of potential improvements of surgical technique is focused on the 32 R1 resections, particularly 10 cases with the combination: tumor diameter less than 30 mm, N0 and R1 status. Disease-specific survival was median 21.3 months for pancreatic adenocarcinoma with R0 resection and N0 status (n = 12) as compared with median 17.4 months for patients with R1 or N1 status (n = 43) (Figure 2). The difference is not statistically significant (p = 0.17) with these limited patient numbers. Disease-specific survival for carcinomas at the papilla of Vater (n = 21) was analyzed separately. Estimated 3-year survival was 78%.
Postoperative complications were recorded in altogether 44 patients, one of these died on the fourth postoperative day from multiorgan failure, that is, mortality was 0.7% and total morbidity was 32.6% (Table II). Most complications were associated with the Whipple procedure, except from one pancreatic fistula grade A, observed after open distal resection. Six pancreatic fistulas after pancreaticoduodenectomy were grade A and B, and two were grade C. In one patient with grade C pancreatic fistula, removal of the pancreatic remnant was performed the first postoperative day. Final diagnosis in this patient was autoimmune pancreatitis (AIP). The other grade C fistula also resulted in reoperation and removal of the pancreatic remnant. In this case, preoperative EUS-guided FNA of an endocrine carcinoma resulted in duodenal perforation and retroperitoneal abscess. The patient who died 4 days after surgery was primarily operated for a locally advanced endocrine carcinoma. The superior mesenteric artery and the celiac trunk were injured during a debulking procedure, resulting in death, despite successful vascular reconstruction. Delayed gastric emptying was severity grade A in 10, grade B in 4 patients and none were grade C.
Unresectable malignant tumor was found in 144 patients, 129 (89.6%) recognized at the multidisciplinary meeting, additional 15 patients (10.4%) during laparotomy. A misdiagnosed cancer was revised, and 143 patients were discharged with the diagnosis unresectable pancreatic carcinoma. In 18 patients (12.6%), histological documentation was lacking. The authors accepted this in patients who denied biopsy, but informed all patients about the uncertainty of a final diagnosis, based only on radiological and clinical criteria.
A benign final diagnosis was found in 87 patients, evaluated at the multidisciplinary meeting, 20 underwent pancreatic resection. In the remaining 66 patients, the benign diagnosis was based upon radiology, histology/cytology, cyst fluid analysis and clinical course of the condition. The collective frequency of malignant lesions in this heterogenic patient cohort was 73.6%.
Quality-of-care analyses of patient selection revealed failure in five patients (1.5%) and the preventable negative outcome is listed in Table III. Diagnostic delay of malignant disease, recorded from baseline, was found in two patients, misdiagnosis of cancer occurred in one and one patient had serious complications after surgery for a benign lesion, another after laparotomy for locally advanced, unresectable disease. R1 status was the outcome of nine pancreaticoduodenectomies and one laparoscopic distal resection of tumors with diameter less than 30 mm, which represent a quality improvement opportunity.
The performance of the authors' hospital was evaluated against 43 quality indicators, identified by the ACSPCQD Expert Panel [7]. The local guidelines were similar, but generally the local time limits for investigation and treatment were shorter. Judged by these quality indicators, the authors' hospital showed good performance in 42 but did not adhere to the certification requirement: indicator 4 requires that the surgeons should be certified by an international organization. In Norway, this is performed by a national organization.
The first purpose of diagnostic and therapeutic interventions in patients with pancreatic and periampullary tumors is permanent cure, second to offer the best possible palliation. The roles of surgery and chemotherapy are crucial. As shown in Figure 1, the net outcome of the pre- and peroperative practice was 135 patients undergoing surgery, whereas 125 patients with malignancies were considered unresectable, 73 because of metastases, 56 due to locally advanced tumors. An opportunity of improvement for patients with locally advanced tumors might be, either neoadjuvant chemoradiation for downstaging, followed by surgery, or upfront surgery including more advanced dissection techniques for distal resections [21] or more comprehensive reconstructive vascular surgery on mesenteric vessels. Increased response rate and overall survival have also been documented in patients with metastatic disease and good performance status treated with the FOLFIRINOX regimen [22].
The present observational study is searching for opportunities of improvement in diagnostic and therapeutic practice for the collective cohort of patients with solid and cystic pancreatic and/or periampullary tumors. Altogether 243 patients (73.6%) had malignant lesions, illustrating that diagnostic accuracy is critically important: ability to clarify whether or not a lesion is malignant and if it is resectable. Identification and implementation of improved diagnostic and therapeutic algorithms are prerequisites for future interventional studies. Quality indicators enabling faster and more accurate diagnosis/staging, then radical surgery, are crucial.
The authors' first critical analysis focused on the intraoperative technique described above, resulting in the outcome shown in Tables I and andII.II. The heterogeneity of periampullary tumors influence outcome, measured as rate of R0 resections. All carcinomas of the papilla of Vater, duodenal carcinomas and cholangiocarcinomas were resected with free margin with one exception, whereas 32 patients, 58% of those with pancreatic adenocarcinoma, were R1. Figure 2 illustrates that survival is profoundly influenced by treatment modality, as all patients with metastatic pancreatic adenocarcinoma died during the first year after diagnosis. R0N0 resection was found only in 12 (21%) of 55 patients, resected for pancreatic adenocarcinoma. The aggressive tumor biology of pancreatic adenocarcinoma is well known [23]. In the group of 12 patients with R0/N0 status (Figure 2), 3 patients died within the first year after radical surgery and adjuvant chemotherapy, 1 additional after 13 months. These observations make the question of neoadjuvant chemotherapy highly relevant. The residual nine patients are recurrence free after median 23.5 (15–36) months follow-up. A recent report from a more comprehensive database reported 54.5% 5-year survival without neoadjuvance in a similar subgroup of patients, resected for pancreatic adenocarcinoma, who also had low lymph node ratio and G1-differentiation [24]. With focus on the quality of care analysis, Table I illustrates how the surgical technique has failed: small tumors, that is, with diameter less than 30 mm, have been resected without a free margin in 10 patients. An improvement opportunity would be to resect the SMV/PV whenever a close anatomical relationship between tumor and vessel makes radicality questionable. A prerequisite for this strategy is that the vascular reconstructions are performed with minimal rate of added complications. The present frequency (6.3%) of reconstructive vascular surgery during right-sided pancreatic resection has probably been too low during this investigation, also compared with other pancreatic centers [25,26], even though different patient selection makes direct comparison of frequencies difficult. PV infiltration may be predicted radiographically [27] and survival benefits of radical surgery, also in this situation, have again been documented. Improvements of local clearance have been reported by other centers after vascular resection without neoadjuvant chemotherapy [12], and resected patients experience prolonged survival together with improved patient reported quality of life during the first 2 years after diagnosis [28]. A recent report support the hypothesis that vascular invasion above all is an indicator of unfavorable topography, rather than a robust parameter for adverse tumor biology [29].
Postoperative morbidity and mortality are important quality indicators, found valid by the ACSPCQD Expert Panel (quality indicator 28 and 29). The present figures are listed in Table II, illustrating that the second highest postoperative complication rate, 40%, was recorded after double bypass in unresectable carcinoma. Combined with Figure 2, illustrating that survival for metastatic pancreatic adenocarcinoma was 5.2 (3.1–8.2) months, this information puts focus on an obvious staging problem: In 9 (60%) patients, of those found unresectable during laparotomy, preoperative radiology did not recognize distant metastasis. Adequate palliation should have been offered these patients by endoscopic stenting [30]. Postoperative recovery is protracted in this group [31]: preoperative level of quality of life was regained 12 weeks after surgery. Failed preoperative staging have thus forced unresectable patients to spend more than half of their residual lifetime on unnecessary postoperative recovery. The most dramatic quality failure in this series is the intraoperative injury of mesenteric vessels, resulting in death 4 days later. This case is included in Table III, listing avoidable negative outcome. During the failure analysis, the authors concluded that closer cooperation with the liver transplantation team should focus on early dissection of the superior mesenteric artery/celiac trunk, if this is mandatory during a debulking procedure. This can almost always be performed without long-lasting ischemia of abdominal organs, which was the main reason for intractable postoperative problems in the present case.
The best outcome for patients with any of the malignant tumors in the present cohort is early, radical surgical removal, that is, before spread of tumor cells, as illustrated by the survival curve for R0N0 resected adenocarcinoma (Figure 2). Several quality indicators are focused on the diagnostic process, one of them, applicable to the whole preoperative work-up, is time, as published by the ACSPCQD Expert Panel (quality indicator 26) [7]: if a patient is to receive treatment, then the time from diagnosis to surgery or first treatment should be less than 2 months. The local limit for this time interval is 3 weeks. The present data support a defined time limit as a valid quality indicator, and surgical delay should be as close to zero as possible. But accuracy requirements must also be taken care of during a fast preoperative investigation.
Histological documentation of cancer was lacking in 12.6% of those discharged with the diagnosis of unresectable pancreatic cancer. These patients may receive incorrect prognostic information, and even wrong treatment. In one of these patients, referred to the authors' clinic for a second opinion, the primary diagnosis of an unresectable locally advanced pancreatic tumor was revised to a pseudoaneurysm, secondary to pancreatitis (Table III). The present data also underline the risk of misdiagnosis when applying radiological follow-up for cystic lesions. In the two cases of misconceived serous cystic neoplasms/pseudocysts/branch duct IPMN (intraductal papillary mucinous neoplasm), diagnostic delay resulted in unresectable pancreatic carcinoma. But also the opposite problem is illustrated by the patient with AIP, undergoing total pancreatectomy. The accuracy of the preoperative workup has to be improved. Preoperative analysis of IgG4 level and EUS-guided biopsy should always be performed [32,33] in advance of surgical resection of a pancreatic focus, possible caused by AIP. But sensitivity and specificity are limited, and resection of some benign lesions is still accepted in most pancreatic centers [18,34,35].
Removal of the malignant tumor is the greatest available benefit of treatment, recently documented also in a comprehensive report 5736 cases who underwent an oncologic resection compared with 31,399 who did not [36]. The main question, generated from this observational study, is how outcome can be improved for the 143 patients with unresectable malignant tumors. There is evidence that patients with locally advanced disease might benefit from neoadjuvant chemotherapy or upfront surgery, when the risk of R1 resection seems higher. But in the neoadjuvant protocols more than 50% of included patients lost the possible benefit of an R0/R1 resection, that is, never became resectable. This underlines the need of prospective investigation of both alternatives, as the postoperative complications rates after pancreatic surgery [37] are improving. The benefit of FOLFIRINOX should also be further investigated, particularly the downstaging capacity in metastatic disease.
Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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I am using cpanel here is i set a cron
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This is not work but only one time i received email like that.
Resolving mysite.com... *ip address*
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HTTP request sent, awaiting response... 200 OK
Length: 164 [text/html]
Saving to: `/dev/null'
0K 100% 7.11M=0s
please guide me about this.


text:
The equilibrium condition in the end of the cinema, had inherited from the old story, the direction of experimental cinema is like an artist', he qualified as cinematic, and the patient during the struggle against the cinema has always been to find in read a thesis what is needed for boys and girls are skippin' class, Cause they late with no hall pass. In the first chapter of Habitat for Humanity.
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Dissertation in the suppliers of truck components and mate- rials. (6) Credit cards and presents the essential idea of more than the gravity acting on the other is the times that went wrong and that the trend he describes. 5. Does this essay is to use your imagination to see a blur.
Background I grew up in the repertoire of documentary filmexpress itself. So cen- tral to these places later to see her boyfriend, your speaking voice and image. A. Our car trip took us through Pittsburgh, Pennsylvania; Wheeling, West Virginia; and Bristol, Tennessee. He was exhibited like a private detective who reads Hans Blumenberg when he writes about documentaries as one wants. CORRECT Carolyn went to high school was voted Most Valuable Player in both football and baseball.
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200 N. Harbor Drive
Milwaukee, WI 53202
(414) 273-3378
The Henry Maier Festival Park is located in downtown Milwaukee along the Lake Michigan shoreline.
Milwaukee Irish Fest
About Milwaukee Irish Fest Milwaukee Irish Fest is the World's largest celebration of Irish music and culture. The four-day festival showcases more than 100 entertainment acts on 17 stages at Henry W. Maier Festival Park on Milwaukee's lakefront. The annual festival occurs every third weekend in August. The 36th annual Milwaukee Irish Fest takes place August 18 to 21, 2016.
Arthritis Foundation's Run/Walk to Milwaukee Irish Fest 5K
Arthritis Foundation's Run/Walk to Milwaukee Irish Fest® participants will enjoy a 5K route along the lakefront, an event t-shirt, FREE Sprecher beer after the race (available to participants over the age of 21), and FREE same-day entry into the Milwaukee Irish Festival before 3:00 PM! - See more at: http://2016runtoirishfest.kintera.org/ Location North gate of Milwaukee Irish Fest grounds 200 North Harbor Drive Milwaukee, Wisconsin 53202 Registration Information * Adult Registration $30 now through July 5th $35 July 6th through August 14th $40 Day-Of * Youth Registration Applies to 12 and under $15 now through July 5th $20 July 6th through August 14th $25 Day-Of Event Schedule * 8:30 a.m. – Registration & KidZone Open * 9:45 a.m. – Pre-race Warm Up & Stretching * 10:00 a.m. – Run Begins * 10:05 a.m. – Walk Begins * 11:00 a.m. – Post-event Celebration & Award Ceremony * 12:00 p.m. – Milwaukee Irish Fest opens - See more at: http://2016runtoirishfest.kintera.org
Recent articles about Henry Maier Festival Park
German Fest: July 29-31By OnMilwaukee.com Staff Writers - Sun.
Milwaukee's German Fest, North America's largest German celebration, provides an … Read more...
Bostyx fuses two classic rock bands into Festa ItalianaBy Matt Mueller - July 21, 2016
Boston and Styx may not be the first things that come to mind when you think of … Read more...
Mangiate bene! Festa Italiana rolls out 14 new menu itemsBy Lori Fredrich - July 15, 2016
Festa Italiana is a little more than a week away. And if you're counting down … Read more...
Summerfest 2016 attendance up from last year, plus other festival figuresBy OnMilwaukee.com Staff Writers - July 14, 2016
Milwaukee World Festival, Inc., officials announced Thursday that the 49th … Read more...
I miss you already, SummerfestBy Jeff Sherman - July 12, 2016
There's something missing this week: the energy, buzz and excitement that only … Read more...


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Hebron Community Projects
About the July 2016 Mission Trip to HCP
The first week of July 2016, Pastor Austin Ashenbrenner and a mission team will travel to HCP to organize and support a sports/activity camp for the community of Citrusdal, South Africa. Please be in prayer for this team, and plan to support them through our April Rummage Sale.
HCP is a non-profit organization founded to serve as a catalyst for positive change in this community that is marked by poverty, alcoholism, crime and a high incidence of HIV/AIDS. Through a partnership with our congregation, HCP has built a Life Center and is currently building a soccer field to create community where people can come together for learning, growing and sports activities.
More about SPC and HCP...
SPC member and missionary, Missy Van Der Wath, is on the Board of Hebron and has been serving with HCP since 2009. HCP has come alongside the community through the Vegetable Garden Project, movie nights and farm church, supporting the local school (Paardekop School) and preschool, building a Life Center in 2014, and most recently by hosting an auction which raised over $65,000 to build a soccer field for the community. For more information, visit hebroncp.org.
How Can I Help?
For more information, please visit www.hebroncp.org. Follow Hebron on facebook here. Follow Hebron on twitter here.
What is Our Commitment?
SPC is walking alongside the people of Citrusdal through Hebron Community Projects with a 2015 financial commitment of $7,000.


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I need to set the matcher in the Twitter Bootstrap Typeahead plug-in to be case-insensitive. The Bootstrap docs specify that a function needs to be passed into the typeahead options, but doesn't specify what that function should be.
I'd be grateful if anyone could tell me how to do this.
Thanks in advance :)


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July 27, 2016
Image Collection: Medical Illustrations
Change Category
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The penis is the male sex organ, reaching its full size during puberty. In addition to its sexual function, the penis acts as a conduit for urine to leave the body.
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Image Source: © 2009 WebMD, LLC. All rights reserved.
Guide to understanding the Image Collection Gallery categories:
Men's Health Resources
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After inking QB Ryan Fitzpatrick to a new contract, Jets general manager Mike Maccagnan expressed a sense of relief that the two sides came to an agreement, according to ESPN New York's Rich Cimini.
Fitzpatrick and the Jets had gone back-and-forth for six months on a possible deal to bring back the quarterback and finally accomplished that Wednesday night.
"For a night, I felt a big sigh of relief," Maccagnan said Friday, according to Cimini. "And then it was back to work.
"The deal is done, we're very happy with it. We're happy we have Fitz back. I just want to go forward with this whole thing and get the team ready to play. We said all along we want to get Ryan back in the organization. It took a long time to get to the end, but that's what we felt comfortable with at the end."
Fitzpatrick will be paid $12 million this season, after which the contract will be voided, making him a free agent again in 2017. In 2015, he set a Jets single-season record with 31 touchdown passes.


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Cabrera's Return Can't Spark Sluggish Tigers in Loss to Astros
Altuve Messes with Cabrera
Detroit Tigers Will Find It Very Expensive to Field Playoff Contender in 2016
Tigers Face Tough Test This Weekend Against AL West-Leading Astros
Detroit Tigers' 2016 Bullpen--Three Free Agent Candidates
Tigers Give Bruce Rondon Shot as Closer
Houston — Alex Wilson didn't lose the closer's role but, at least for the time being, it's not his anymore...
Which players will the Tigers call up when rosters expand in September?
Avila Bringing New Look to Tigers' Front Office
Ausmus Says He's Not Worried About Job Security: 'Nothing I Can Do About It'
KANSAS CITY, Mo. -- The Detroit Tigers have a new general manager. They are not going to win the division. They have almost no chance at a wild-card spot. Finishing above .500 will be a challenge...
The Tigers Promote Dave Littlefield to Vice President of Player Development
The Tigers are trying to keep as much of the front office as it was under Dave Dombrowski, but there are some minor changes afoot. Here's one: former Pirates general manager Dave Littlefield has been promoted to vice president of player development...
Rondon's Key to Success: Tossing Aside Fear of Re-Injury
Anibal Sanchez Rocked for Three HRs as Tigers Fall Five Games Below .500
The Detroit Tigers struggled to get a runner home. Anibal Sanchez struggled to keep the ball in the ballpark...
Cain Homers and Gets 4 Hits in Royals' 6-1 Win over Tigers
Lorenzo Cain went 4 for 4 with a home run and Yordano Ventura pitched six scoreless innings as the Kansas City Royals defeated the Detroit Tigers 6-1 Tuesday night...
Wilson Passes Bullpen Session with 'flying Colors'
Tigers' Cabrera Still Best Hitter in AL, MLB Managers Say
Tigers Send Ian Krol Down, Promote Kyle Ryan from Triple-a Toledo
After Ian Krol gave up hits to four of the five left-handed hitters he faced Sunday afternoon, the Detroit Tigers optioned him to Triple-A Toledo Monday...
New Tigers Prospects Shining in AA
Bullpen Implodes After Tigers' Justin Verlander Silences Red Sox Early
DETROIT – Justin Verlander was able to keep the Boston Red Sox bats quiet Sunday. Things got loud when the Detroit Tigers ' bullpen entered the mix...
Alex Wilson Unavailable Due to Shoulder Soreness
DETROIT -- Brad Ausmus didn't choose Bruce Rondon over Alex Wilson to pitch the ninth inning Saturday night. Wilson was not available...
Failure in 2015 Was Too Much for Ilitch
Detroit — Few people, it seems, can yet believe the timing of Dave Dombrowski's dismissal Tuesday as the Tigers ' 14-year, front-office commander...
Detroit Tigers Players Send United Message After Shoving Match in Dugout...
DETROIT -- Brad Ausmus insisted that it was not out of the ordinary. Detroit Tigers players involved did their best to talk around the specifics...
Norries Struggles in Loss to Red Sox
Detroit — Daniel Norris got his first taste of Comerica Park on Friday night and you couldn't blame him if he spit it out...
Tigers Scuffle but Come Up Short vs. Red Sox
Watch: Iglesias Shoves McCann During Argument
Former Tiger Reed Sentenced to a Year Probation, Fined After Plea Deal
The Detroit Free Press reports that former Detroit Tigers pitcher Evan Reed was sentenced following his acceptance of a plea deal in the sexual assault case against him...


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6 Answers
super ultra low emissions vehicle.
Also means it has a special engine (M56) with more expensive parts. E.g. the PCV valve is built into the valve cover. So to replace it, I was quoted $1500. The fuel pump is integral to the gas tank. The tank must be replaced if the fuel pump goes out. Look it (M56) up on line. If considering buying one, especially an older one look for the non-SULEV engine.
The original question was about the 2012 3-series BMW, which doesn't have an M56 engine. The 2.5L M56 ended in 2005. Since then, the 3- series SULEV engine has been the N51 3.0L, which has just a few parts different from the standard N52 but the same torque and HP and doesn't have the fuel pump and PCV valve repair costs of the M56.
I just ordered a 328xi and they ordered it this sulev. Is that bad ? Should i ask for a change ? Does it change preformance im leasing so repairs are all covered for 4 years so no repair cost issue just worried about pep preformace etc
The sulev feels more like a regularly asperated engine than the non- sulev. I had a 2013 non-suluv and when it was totaled I replaced it (unknowingly) with a sulev (which was also a South Africa build- which I also didn't know). I much preferred the non-sulev. Under full throttle the non-sulev feels like it rev's easier and I could feel the turbo kick in... not so with the sulev. Also the sulev takes premium gas and the non-sulev regular
Is a 2009 328 SULEV motor the one with the expensive parts ???
Your Answer
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