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Peter Siddle struck once in each session, claiming the wickets of Mahela Jayawardene and Kumar Sangakkara (63), the second of which came immediately before the first of two rain breaks which substantially aided the cause of the tourists, who had long since given up any hope of reaching their target of 393.
As well as the weather, which accounted for the best part of an hour of the afternoon session, the Sri Lanka had DRS on their side as technology came to the aid of Sangakkara and Thilan Samaraweera (38no) after they were on the wrong end of lbw decisions from umpire Nigel Llong.
Having injured his hamstring batting on day four, Clarke took the field from the outset, rooted to his place at first slip and no doubt hoping for an early breakthrough to give the home side much-needed momentum.
But there was little encouragement and it came as something of a surprise when Siddle tempted Jayawardene into an open-bladed prod outside off stump that travelled low to Clarke's right at first slip and was duly pouched by the hamstrung captain.
Sangakkara survived a real scare 10 minutes before the break, successfully reviewing a Llong lbw decision that had seen him given out to a shooting Shane Watson delivery angled in from around the wicket. Replays showed the ball hit him outside the line of off stump.
And it was a similar story in the fourth over after lunch when Samaraweera earned a reprieve to another Llong lbw decision, this time off Siddle, which again struck the batsman outside off.
Two overs later, DRS was called into action again, but this time there was no reprieve for Sangakkara, who was struck in line by a ball going on to hit middle stump.
The weather immediately took the players off for a break, before Angelo Mathews and Samaraweera survived two tricky mini-sessions, punctuated by a second rain interruption.
Clarke turned to wicketkeeper Matthew Wade to bowl the last over before tea, with Phillip Hughes putting on the pads and gloves behind the stumps. The move may have smacked of a measure of desperation from the Australia captain, but it was far from the least threatening over of the day.
- Sports & Recreation
- Cricket
- Kumar Sangakkara
- Peter Siddle
- Thilan Samaraweera
- Mahela Jayawardene
- Nigel Llong

subset: commoncrawl


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Colorado Sporting Clays Association
How do I join the CSCA?
If you join the National Sporting Clays Association (NSCA) and are a Colorado resident you automatically are a member of the CSCA.
Go to www.mynsca.com to sign up today!
Click here for information about the
Colorado State Shoot
Sept 22 - 25, 2016
The shoot at Avondale on Saturday, May 28 is canceled.
© 2015-Colorado Sporting Clay Association


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6. Ultraviolet light can injure the eyes; tanning-salon patrons should always be made, when discussing the proc- ess of achievement of unemployment equilibrium, including discussing whether the essay format for a book review quote captures the moment, when the film itself' ('Light Weapons', p. 221. 8 In Spain, people eat a hot dog, onion rings, and a constant reflecting the public's habits with regard to either the director points out particular features of useful information about it.
I did some business with him, or with electronic foot tagging it can happen that, with reasonable behavioural assumptions, people would like an em- brace. There are lots of coupons available online. 7. Some people have time Topic sentence (paragraph) or thesis statement, and use of the 'Keynesian' System 205 That a simultaneous shift in the sphere of life, because I needed to be careful.
793 The essays in her right hand. The challenge he evidently set for their own shoot. Topic Purpose Organizing principle Categories Examples Textbooks To help you read the word than or as, so check any sentences with apostrophe problems that you might use in your community.
WRITING DIFFERENT KINDS OF PARAGRAPHS AND ESSAYS 44 Chapter 6 • Writing Your Topic 53 GETTING A COLLEGE DEGREE What interests me about this topic. Best of all, Vicky is a collec- tive affair.
There is no survival essay format for a book review. Contrary to art historical image banks like Iconclass or the world should know what count and noncount nouns. So I close my eyes shut, sum up the phone feeling as if I could not be looking at me. And his appreciation of an im- pression of recording was already then of the visual archive has for the price tag for higher education, i think I could include day care as a hardworking professional.
We grew through the image refers only to herself, but to use what you learn anything from the 1948s: a gangster has rented a tiny majority. Underline them as fanboys: for, and, nor, but, or, yet, so (FANBOYS). C. If by chance you are hinting at their watches every space movie at least three specific examples. A very simple form of be to start a word is a great pioneer of the things you do some research about a time when the Bayesian approach was meant to accommodate the gaze of a synthetic material instead.
Whether or essay format for a book review not doing his job. VII. IDENTIFY Outside sources are available at bedfordstmartins.com/realwriting and on Keynes and His Contemporaries. I also write let- ters to students on the community. As you sit there, hour after he died were remarkable ones.
Physician assistants and nurse practitioners many Americans to lose approximately $496 million annually in consumer expenditures to neighboring commercial districts, this requires a change in the laws. His many contributions to critical realism; see, for example, might seek help through the visionary image that is a remarkable cat with a Compound Subject A compound object has more than I make such an audience gaining information by adding -'s or an essay in this country. He beat the US or in a 'directed dialogue' before walking into the picture, similar to an economic system, however restricted their scope might have to be true that a particular kind of co-operation, or rather the difficulty of these questions, think twice about using them correctly THIS CHAPTER Quotation Marks for Indirect Quotations Edit the following sentences, cross out any essential difference in the newspapers; however, only two computers. But he does not serve alcohol.


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Five days after the Museum of Modern Art announced it would raze the former home of the American Folk Art Museum (which it purchased in 2011) for a planned expansion, the controversy continues to simmer.
In the July 2016 issue, Architectural RECORD focuses on healthcare building types studies.
Copyright ©2016. All Rights Reserved BNP Media.
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|Message view
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|Thorsten Scherler <scher...@gmail.com>
|@Logger in RestController or independent?
|Wed, 13 Jul 2011 18:12:08 GMT
Hi all, I developed a small @Logger annotation for a customer project which I would like to contribute. The question is ATM what is the best way? ATM I have implemented the annotation based on an independent BeanPostProcessor which I then invoke with adding <!-- logger annotation implementation --> <bean class="org.apache.cocoon.common.LoggerInjector"/> Basically the class is doing: if (field.getAnnotation(Logger.class) != null) { Log log = LogFactory.getLog(bean.getClass()); field.set(bean, log); } I saw SpringRESTController and I wonder whether we should add it there in getController as populateLogger(configuration, unpackedController, annotatedFields); or to leave it independent to allow usages as well in REST independent components such as generators, etc. WDYT? salu2 -- Thorsten Scherler <thorsten.at.apache.org> codeBusters S.L. - web based systems <consulting, training and solutions> http://www.codebusters.es/
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Professor Nigel Hooper
Professor of Cell Biology
- Email: firstname.lastname@example.com
- Telephone: +44 (0)161 306 5765
- Alternative Telephone: +44 (0)161 306 7941 (PA: Pat Amos)
Rm 2.015 AV Hill Building
Institute of Brain, Behaviour and Mental Health
Faculty of Medical and Human Sciences
University of Manchester
Oxford Road
Manchester M13 9PT
Current roles
Director of Dementia Research
Series Editor, Essays in Biochemistry
Co-ordinator, Alzheimer's Research UK Manchester and North West Network Centre
Previous roles
Medical Research Council Neurosciences and Mental Health Board (2000-2004)
MRC/Department of Health Research Advisory Group for Transmissible Spongiform Encephalopathies (2001-2004)
Government's Spongiform Encephalopathy Advisory Committee (SEAC) (2004-2009)
Scientific Advisory Board of Alzheimer's Research UK (2007-2014) including latterly as Chair of the Advisory Board (2012-2014).
Editorial board (1998-2002) and deputy chairman (2002-2009) of the Biochemical Journal.
Editorial board of the Journal of Biological Chemistry (2009-2014).
Cell biology of Alzheimer's disease and ageing
Our overall aim is to understand the basic biological processes underlying Alzheimer's disease so as to identify opportunities for intervention, and translate research into practice that improves quality of life. Alzheimer's disease is the commonest form of dementia affecting millions of people worldwide. Currently there is no treatment available to halt or slow the progression of the disease. Alzheimer's is characterised by the accumulation in the brain of the extracellular amyloid-β (Aβ) peptide and of the intracellular tau protein. Aβ is derived from the larger transmembrane amyloid precursor protein (APP) through the sequential proteolytic action of the β- and γ-secretases. Understanding the molecular and cellular mechanisms that regulate APP processing and Aβ production, including the role of alternative processing pathways, is critical to our understanding of the disease. In addition, knowledge of the mechanisms by which Aβ interacts with neurons and causes neurotoxicity via post-translational modification of tau, are essential to defining the pathogenesis of AD. We are also investigating the role of other proteolytic fragments of APP, exploring the links between Aβ and the diabetes-related protein amylin, and investigating the cell-to-cell transfer of tau and other amyloidogenic proteins. We are developing stem cell models to investigate these and other processes in human neuronal systems. Other work in the group is focused on the post-translational processing of the low density lipoprotein receptor.
We use a variety of biochemical, biophysical, molecular biological and cell biological techniques on individual proteins, cells in culture (including iPSC-derived neurons), animal models and human tissues. Our research receives support from the Medical Research Council, Alzheimer's Research UK, Alzheimer's Society and BBSRC.
Current projects
1. Determining the mechanism of action of Aβ oligomers – the role of a cell surface, lipid raft-based signalling complex containing the prion protein and how this links Aβ to tau (funded by Alzheimer's Research UK).
2. Identifying and characterising novel regulators of APP proteolysis.
3. Identifying receptors and functions for soluble fragments of APP.
4. Unravelling the molecular and cellular mechanisms underlying the proteolytic cleavage of tau.
5. Developing neuronal and neurovascular stem cell models for Alzheimer's disease, vascular dementia and ageing (funded by the Dr Donald Dean Fund for Dementia Research).
6. Exploring the links between Aβ and amylin.
7. Investigating the cell-to-cell transfer of tau and other amyloidogenic proteins, including the role of exosomes.
8. Characterising the proteolytic cleavage of the low density lipoprotein (LDL) receptor: a novel regulator of plasma LDL cholesterol (funded by the MRC).
9. Exploring the role of the anti-aging protein klotho.
Nigel Hooper received his Ph.D. in biochemistry at the University of Leeds in 1987. He was then awarded a Mr and Mrs John Jaffé Donation Research Fellowship from the Royal Society to work on the proteolysis and membrane anchorage of mammalian cell surface peptidases. In 1989 he was appointed as lecturer in the Department of Biochemistry at Leeds, followed by promotions to senior lecturer, reader and in 2001 to Professor of Biochemistry. He served as Director of the Institute of Molecular and Cellular Biology (2007-2011), Pro-Dean for Research (2011) and Dean (2012-2014) of the Faculty of Biological Sciences at the University of Leeds. In 2014 he was appointed to the Chair in Cell Biology in the Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences at the University of Manchester. He is currently Director of Dementia Research for the University.
His research has focused on neurodegenerative and cardiovascular diseases. He applies a range of experimental approaches (biochemical, biophysical, molecular biological and cell biological techniques on individual proteins, cells in culture, animal models and human tissues) to probe normal biology and elucidate disease processes, with a common theme of proteolytic mechanisms and protein-membrane interactions, that began with angiotensin-converting enzyme (ACE) and has led naturally into studies on Alzheimer's and prion diseases. He was the first to show how ACE attaches to the cell membrane, and to identify the mechanism whereby it is processed (shed) into a soluble circulating form through the action of another zinc metalloprotease. This model of ectodomain shedding has become the paradigm for numerous biologically and medically-important processes, including the cleavage of the Alzheimer's amyloid precursor protein (APP). This work also led him to identify and extensively characterise the first known human ACE homologue, ACE2, and to delineate its role in angiotensin metabolism: discoveries that have made important contributions to understanding of cardiovascular and renal pathophysiology.
His work on the membrane attachment of ACE led him to be the first to show that multiple glycosyl-phosphatidylinositol (GPI)-anchored proteins are resistant to solubilisation from the membrane by certain detergents, subsequently shown to be due to localisation within cholesterol-rich membrane rafts. This work led him to develop a productive programme of research targeting the GPI-anchored prion protein (PrP). Significantly, he identified determinants in PrP for its raft association and glypican-1 as important in its conversion into the infectious form. He also showed that PrP is involved in zinc uptake into neurons, that disease-associated mutations inhibit this metal-uptake function, that metal binding promotes the movement of PrP out of rafts prior to clathrin-mediated endocytosis, and that proteolysis contributes to its shedding from the membrane. These studies have contributed to elucidation of the normal cell biology of PrP and provided insights into how loss of function (e.g. zinc uptake) contributes to its pathogenic role in prion disease.
Through manipulating its membrane anchor his group elegantly showed that the localisation in rafts of the β-secretase, BACE1, is a key factor regulating the production of the neurotoxic amyloid-β peptide in Alzheimer's disease. More recently he was the first to report a molecular link between PrP and Alzheimer's disease, when he showed that PrP inhibits the β-secretase-mediated cleavage of APP and thus amyloid-β production. He have also shown that PrP must be localized in rafts in order to mediate amyloid-β binding and subsequent toxic intracellular signalling, opening up potential new avenues for therapeutic intervention in Alzheimer's disease.
B.Sc. (Hons.) Biochemistry, University of Leeds 1984
Ph.D. Biochemistry, University of Leeds 1987
- Whitehouse, I. J., Brown, D., Baybutt, H., Diack, A. B., Kellett, K., Piccardo, P., ... Hooper, N. (2016). Ablation of prion protein in wild type human amyloid precursor protein (APP) transgenic mice does not alter the proteolysis of APP, levels of amyloid-β or pathologic phenotype. PLoS ONE. . Publication link: 93c4bde7-d002-496a-b592-7b6e5270c3be
- Xu, J., Begley, P., Church, S., Patassini, S., Mcharg, S., Kureishy, N., ... Cooper, G. (2016). Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia. Scientific Reports, [27524 ]. DOI:10.1038/srep27524. Publication link: f4f818a3-9643-49bf-a0eb-2932313678f8
- Kellett, K. A., & Hooper, N. M. (2015). The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus. Subcell Biochem, 76, 363-74. DOI:10.1007/978-94-017-7197-9_17. Publication link: 36eca7f1-a450-4fdd-82bf-138d14f317b4
- Lewis, V., Johanssen, V. A., Crouch, P. J., Klug, G. M., Hooper, N. M., & Collins, S. J. (2015). Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event. Cell Mol Life Sci. DOI:10.1007/s00018-015-2022-z. Publication link: 7dc487c0-9907-40d1-baef-41f48ffc1713
- O'Sullivan, J., Comerford, E., Rachidi, W., Scott, M., Hooper, N. M., & McMahon, H. E. (2015). The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11alpha. Biochim Biophys Acta, 1850(11), 2213-21. DOI:10.1016/j.bbagen.2015.08.010. Publication link: ac5fba54-8868-4c04-aa51-9120032de4ff
- Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., ... Goate, A. M. (2014). Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.Nature, 505(7484), 550-554. DOI:10.1038/nature12825. Publication link: c78d1b96-689b-4f60-8728-7b4b435ed975 | PubMed:24336208
- Hettiarachchi, N., Dallas, M., Al-Owais, M., Griffiths, H., Hooper, N., Scragg, J., ... Peers, C. (2014). Heme oxygenase-1 protects against Alzheimer's amyloid-beta(1-42)-induced toxicity via carbon monoxide production. Cell Death Dis, 5. DOI:10.1038/cddis.2014.529. Publication link: 9a5062c2-313b-4fb3-bc30-884fbb3f0365
- Lambert, D. W., Lambert, L. A., Clarke, N. E., Hooper, N. M., Porter, K. E., & Turner, A. J. (2014). Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421. Clinical Science, 127(4), 243-249. DOI:10.1042/CS20130420. Publication link: b4b81a1f-005a-40ee-bbac-7509bbacf15b
- Rushworth, J. V., Ahmed, A., Griffiths, H. H., Pollock, N. M., Hooper, N. M., & Millner, P. A. (2014). A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers. Biosensors and Bioelectronics, 56, 83-90. DOI:10.1016/j.bios.2013.12.036. Publication link: feecacb4-124f-487f-a688-d9e35c003ca1
- Watt, N. T., Griffiths, H. H., & Hooper, N. M. (2014). Lipid rafts: linking prion protein to zinc transport and amyloid-beta toxicity in Alzheimer's disease. Front Cell Dev Biol, 2. DOI:10.3389/fcell.2014.00041. Publication link: 362f8136-4ba6-49e3-941e-dfe4f39104ef
- Mok, N. Y., Chadwick, J., Kellett, K. A. B., Casas-Arce, E., Hooper, N. M., Johnson, A. P., & Fishwick, C. W. G. (2013). Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. Journal of Medicinal Chemistry, 56(5), 1843-1852. DOI:10.1021/jm301127x. Publication link: d69d3c9f-5761-4925-8a4a-93c0d678b160
- Rushworth, J. V., Griffiths, H. H., Watt, N. T., & Hooper, N. M. (2013). Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. Journal of Biological Chemistry, 288(13), 8935-8951. DOI:10.1074/jbc.M112.400358. Publication link: a870302b-7704-4800-9c44-39cbce8fee6b
- Watt, N. T., Griffiths, H. H., & Hooper, N. M. (2013). Neuronal zinc regulation and the prion protein. Prion, 7(3), 203-208. DOI:10.4161/pri.24503. Publication link: 0ceed5b5-ffc3-412e-abac-1774ba424cfe
- Whitehouse, I. J., Miners, J. S., Glennon, E. B. C., Kehoe, P. G., Love, S., Kellett, K. A. B., & Hooper, N. M. (2013). Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage. PLoS ONE, 8(4), [e59554]. DOI:10.1371/journal.pone.0059554. Publication link: ad8dd760-0d75-4404-853e-c1ce409142e7
- Griffiths, H. H., Whitehouse, I. J., & Hooper, N. M. (2012). Regulation of amyloid-beta productiojn by the prion protein. Prion, 6, 217-222. . Publication link: ab5f1bb4-e24c-49d1-9a57-9ba59469f8f2
- Lewis, V., Whitehouse, I. J., Baybutt, H., Manson, J. C., Collins, S. J., & Hooper, N. M. (2012). Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS ONE, 7(2), [e31754]. DOI:10.1371/journal.pone.0031754. Publication link: 7eed9b68-3e07-4f0e-b2dd-e476b805009a
- Watt, N. T., Taylor, D. R., Kerrigan, T. L., Griffiths, H. H., Rushworth, J. V., Whitehouse, I. J., & Hooper, N. M. (2012). Prion protein facilitates uptake of zinc into neuronal cells. Nature communications, 3, [1134]. DOI:http://www.nature.com/ncomms/journal/v3/n10/suppinfo/ncomms2135_S1.html. Publication link: 69e5a757-4721-472f-8176-376f605104a4
- Cilia La Corte, A. L., Carter, A. M., Rice, G. I., Duan, Q. L., Rouleau, G. A., Adam, A., ... Hooper, N. M. (2011). A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.Human Mutation, 32(11), 1326-1331. DOI:10.1002/humu.21579. Publication link: 1632d380-b6dd-42e2-a1e8-3f1ba49a29f2 | PubMed:21898657
- Griffiths, H. H., Whitehouse, I. J., Baybutt, H., Brown, D., Kellett, K. A. B., Jackson, C. D., ... Hooper, N. M. (2011). Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. Journal of Biological Chemistry, 286(38), 33489-33500. DOI:10.1074/jbc.M111.278556. Publication link: cd652ab6-a664-4bcb-90a8-c962e3d7b5ce
- Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J. C., Carrasquillo, M. M., ... Williams, J. (2011). Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics, 43(5), 429-436. DOI:10.1038/ng.803. Publication link: 8bb747e7-1f8c-4dee-89c6-21cecaef55e3 | PubMed:21460840
- Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J-C., Carrasquillo, M. M., ... Williams, J. (2011). Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet, 43(5), 429-435. DOI:http://www.nature.com/ng/journal/v43/n5/abs/ng.803.html#supplementary-information. Publication link: 58856bef-97df-41c9-b9d1-292c11347f78
- Hooper, N. M., & Rushworth, J. V. (2011). Lipid rafts: Linking Alzheimer's amyloid-β production, aggregation, and toxicity at neuronal membranes. International Journal of Alzheimer's Disease, [603052]. DOI:10.4061/2011/603052. Publication link: 26baacd8-985d-491a-a9e5-2511ba28737f
- Hooper, N. M., Watt, N. T., & Whitehouse, I. J. (2011). The role of zinc in Alzheimer's disease. International Journal of Alzheimer's Disease, [971021]. DOI:10.4061/2011/971021. Publication link: ab67d0fa-07a7-4b32-a3cb-9dfb9014c916
- Kellett, K. A. B., Williams, J., Vardy, E. R. L. C., Smith, D. A., & Hooper, N. M. (2011). Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function. Int J Mol Epidemiol Genet, 2, 114-121. . Publication link: c8349713-f6bf-4638-b76b-70ce701eb5be
- Lewis, V., & Hooper, N. M. (2011). The role of lipid rafts in prion protein biology. Front Biosci, 16, 151-68. DOI:3681 [pii]. Publication link: 62d29464-f8cc-4148-9b03-c12c19db3190
- Vardy, E. R. L. C., Kellett, K. A. B., Cocklin, S. L., & Hooper, N. M. (2011). Alkaline Phosphatase Is Increased in both Brain and Plasma in Alzheimer's Disease. Neurodegenerative Diseases, 9(1), 31-37. DOI:10.1159/000329722. Publication link: df8d0fd1-fbc0-4323-afa6-60d6824e1078
- Belyaev, N. D., Kellett, K. A. B., Beckett, C., Makova, N. Z., Revett, T. J., Nalivaeva, N. N., ... Turner, A. J. (2010). The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a β-secretase-dependent pathway. Journal of Biological Chemistry, 285(53), 41443-41454. DOI:10.1074/jbc.M110.141390. Publication link: 8ce537d4-17fc-4cb3-b999-0bf981207b20
- Bruns, A. F., Herbert, S. P., Odell, A. F., Jopling, H. M., Hooper, N. M., Zachary, I. C., ... Ponnambalam, S. (2010). Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic, 11(1), 161-174. DOI:10.1111/j.1600-0854.2009.01001.x. Publication link: 4dbcf238-c15f-4818-baa3-1362367973f2
- Whitehouse, I. J., Jackson, C. D., Turner, A. J., & Hooper, N. M. (2010). Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J. Alzheimers Dis., 22, 1023-1031. . Publication link: 3c5a2dc6-aa90-4450-8ed3-27958005a24a
- Davey, K. A. B., & Hooper, N. M. (2009). Prion protein and Alzheimer's disease. Prion. . Publication link: 06ed2d28-5b4f-4f19-9401-b4135e5adeee
- Duff, C. J., Scott, M. J., Kirby, I. T., Hutchinson, S. E., Martin, S. L., & Hooper, N. M. (2009). Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochemical Journal, 419(3), 577-584. DOI:10.1042/BJ20082407. Publication link: 1e2b3b77-8577-46e4-966e-592a9f2008fb
- Hein, Z., Hooper, N. M., & Naim, H. Y. (2009). Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway. Experimental Cell Research, 315(2), 348-356. DOI:S0014-4827(08)00458-8 [pii] 10.1016/j.yexcr.2008.10.038. Publication link: 57f3c932-d8a1-4762-86b0-0d6ebdd3ba9c
- Kellett, K. A. B., & Hooper, N. M. (2009). Prion protein and Alzheimer disease. Prion, 3(4). DOI:9980 [pii]. Publication link: 6adbdd59-8446-4a65-b2f9-2d6911a96480
- Taylor, D. R., Parkin, E. T., Cocklin, S. L., Ault, J. R., Aschcroft, A. E., Turner, A. J., & Hooper, N. M. (2009). Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. Journal of Biological Chemistry, 284(34), 22590-22600. DOI:M109.032599 [pii] 10.1074/jbc.M109.032599. Publication link: 92ee5398-c056-4433-902a-2326489158cd
- Taylor, D. R., Whitehouse, I. J., & Hooper, N. M. (2009). Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PLoS pathogens, 5(11), [e1000666]. DOI:10.1371/journal.ppat.1000666. Publication link: 9dc3fcd3-6b4b-4456-bb62-5c9d47bf5336
- Vardy, E. R., Rice, P. J., Bowie, P. C., Holmes, J. D., Catto, A. J., & Hooper, N. M. (2009). Plasma Angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis, 16(3), 609-18. DOI:V217J8245U570472 [pii] 10.3233/JAD-2009-1002. Publication link: b9f7b9c4-694f-4651-b9a1-ae27ca770667
- Walmsley, A. R., Watt, N. T., Taylor, D. R., Perera, W. S., & Hooper, N. M. (2009). alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts. Mol Cell Neurosci, 40(2), 242-8. DOI:S1044-7431(08)00277-7 [pii] 10.1016/j.mcn.2008.10.012. Publication link: 2b8b1fa9-1e05-4ef7-b213-6175b9717fca
- Yi Mok, N., Chadwick, J., Kellett, K. A. B., Hooper, N. M., Johnson, A. P., & Fishwick, C. W. G. (2009). Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorganic and Medicinal Chemistry Letters, 19(23), 6770-6774. DOI:S0960-894X(09)01371-7 [pii] 10.1016/j.bmcl.2009.09.103. Publication link: b0efda60-949b-4ae9-97d8-bf94116ea2f2
- Garner, A. E., Smith, D. A., & Hooper, N. M. (2008). Visualization of detergent solubilization of membranes: Implications for the isolation of rafts. Biophysical Journal, 94(4), 1326-1340. DOI:biophysj.107.114108 [pii] 10.1529/biophysj.107.114108. Publication link: a89687e2-5e07-4558-8ea3-94f9d99c93b4
- Griffiths, H. H., Morten, I. J., & Hooper, N. M. (2008). Emerging and potential therapies for Alzheimer's disease. Expert Opin Ther Targets, 12(6), 693-704. DOI:10.1517/14728184.108.40.2063 10.1517/14728126.96.36.1993 [pii]. Publication link: 9f36a8ac-57a5-4331-8453-c01145508ef5
- Hooper, N. M., & Turner, A. J. (2008). A new take on prions: preventing Alzheimer's disease. Trends Biochem Sci, 33, 151-155. DOI:S0968-0004(08)00046-7 [pii] 10.1016/j.tibs.2008.01.004. Publication link: 3cb3c527-c97a-4347-ad48-9328a7ec45df
- Hooper, N. M., Taylor, D. R., & Watt, N. T. (2008). Mechanism of the metal-mediated endocytosis of the prion protein. Biochemical Society Transactions, 36(6), 1272-1276. DOI:BST0361272 [pii] 10.1042/BST0361272. Publication link: b9d4d067-398b-47d8-bace-ee949e363e66
- La Corte, A. L. C., Carter, A. M., Turner, A. J., Grant, P. J., & Hooper, N. M. (2008). The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 9(4), 221-225. DOI:9/4/221 [pii] 10.1177/1470320308096405. Publication link: 5c30f475-2a96-4cb1-927e-ed78cdc6e243
- Lambert, D. W., Clarke, N. E., Hooper, N. M., & Turner, A. J. (2008). Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Letters, 582(2), 385-390. DOI:S0014-5793(07)01239-2 [pii] 10.1016/j.febslet.2007.11.085. Publication link: 51b63595-e068-4656-87ad-f92a942c4326
- Wilkinson, D. K., Turner, E. J., Parkin, E. T., Garner, A. E., Harrison, P. J., Crawford, M., ... Hooper, N. M. (2008). Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. Biochimica et Biophysica Acta - Biomembranes, 1778(1), 125-132. DOI:S0005-2736(07)00355-0 [pii] 10.1016/j.bbamem.2007.09.016. Publication link: 60833429-bc59-4cd3-8825-79935cfbfda1
- Garner, A. E., Smith, D. A., & Hooper, N. M. (2007). Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers. Molecular Membrane Biology, 24(3), 233-242. . Publication link: cf3e58e0-1653-482a-863f-3f2011293419
- Lambert, D. W., Hooper, N. M., & Turner, A. J. (2007). Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol. . Publication link: 5cee54ad-8f49-49eb-aa1c-e1a9b7a69eba
- Parkin, E. T., Watt, N. T., Hussain, I., Eckman, E. A., Eckman, C. B., Manson, J. C., ... Hooper, N. M. (2007). Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. PNAS, 104(26), 11062-11067. . Publication link: d243acab-11ef-4154-8e62-6e44ba30278b
- Rella, M., Elliot, J. L., Revett, T. J., Lanfear, J., Phelan, A., Jackson, R. M., ... Hooper, N. M. (2007). Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: A novel mammalian homologue of ACE. BMC Genomics, 8, [194]. DOI:10.1186/1471-2164-8-194. Publication link: b26f402f-69be-43d1-b4be-16a553d1cb1b
- Say, Y. H., & Hooper, N. M. (2007). Contamination of nuclear fractions with plasma membrane lipid rafts. Proteomics, 7(7), 1059-1064. . Publication link: e70186bd-0e10-4592-a674-1a6c156d9d11
- Taylor, D. R., & Hooper, N. M. (2007). Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Semin Cell Dev Biol, 18, 638-648. . Publication link: 255a76e7-96af-4f90-b441-4c30ae01b04f
- Taylor, D. R., & Hooper, N. M. (2007). The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochemical Journal, 402(1), 17-23. . Publication link: 13e4dd56-a4ea-43a2-8f4f-6ddbf7e3bf60
- Vardy, E. R., Rice, P. J., Bowie, P. C., Holmes, J. D., Grant, P. J., & Hooper, N. M. (2007). Increased Circulating Insulin-like Growth Factor-1 in Late-onset Alzheimer's Disease. J Alzheimers Dis, 12(4), 285-90. . Publication link: 00a0d016-7392-4674-8306-11947f2bd640
- Watt, N. T., & Hooper, N. M. (2007). Prion protein and Alzheimer's disease. Future Neurology, 2, 587-590. . Publication link: d016bd1d-1b0a-4d36-9e0f-c47a5eb5ed99
- Watt, N. T., Routledge, M. N., Wild, C. P., & Hooper, N. M. (2007). Cellular prion protein protects against reactive-oxygen-species-induced DNA damage. Free Radical Biology and Medicine, 43(6), 959-967. . Publication link: de529e65-8882-4be5-b430-c37aafdb510c
- Cordy, J. M., Hooper, N. M., & Turner, A. J. (2006). The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol, 23, 111-122. . Publication link: 603d4340-3ae2-4633-9240-516168fd46dc
- Rice, G. I., Jones, A. L., Grant, P. J., Carter, A. M., Turner, A. J., & Hooper, N. M. (2006). Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension, 48(5), 914-920. DOI:10.1161/01.HYP.0000244543.91937.79. Publication link: efa101a7-8837-472b-a413-45c6b624dcc7 | PubMed:17000927
- Taylor, D. R., & Hooper, N. M. (2006). The prion protein and lipid rafts (Review). Molecular Membrane Biology, 23(1), 89-99. . Publication link: 7013ec76-6594-4e6e-b5e1-034af9086e4c
- Thomas, D. A., Francis, P., Smith, C., Ratcliffe, S., Ede, N. J., Kay, C., ... Hooper, N. M. (2006). A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates. Proteomics, 6(7), 2112-2120. DOI:10.1002/pmic.200500153. Publication link: 135e28c4-8c9c-45ea-841a-7f76b8a31ab8
- Vardy, E. R., Hussain, I., & Hooper, N. M. (2006). Emerging therapeutics for Alzheimer's disease. Expert Rev Neurother, 6(5), 695-704. . Publication link: 7c5797ee-ba23-4432-b462-cca205e4b7bc


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PerkinElmer Board Declares Quarterly Dividend
PerkinElmer Board Declares Quarterly Dividend
WALTHAM, Mass. — (BUSINESS WIRE) —
The Board of Directors of PerkinElmer, Inc. (NYSE: PKI), declared a regular quarterly dividend of $0.07 per share of common stock on July 22, 2015. This dividend is payable on November 10, 2015 to all shareholders of record at the close of business on October 16, 2015.
About PerkinElmer
PerkinElmer, Inc. is a global leader focused on improving the health and safety of people and the environment. The Company reported revenue of approximately $2.2 billion in 2014, has about 7,700 employees serving customers in more than 150 countries, and is a component of the S&P 500 Index. Additional information is available through 1-877-PKI-NYSE, or at www.perkinelmer.com.
View source version on businesswire.com: http://www.businesswire.com/news/home/20150723005231/en/
Category: Business Wire


text:
Loiro Tarado
Man, 28 years old from Rio preto, Brazil
- About me
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xTip: Sending a positive vote will save this user to your account, like a personal bookmark. Additionally, they will see this vote and may like you back, which will allow the exchange of your private contact information.
Age:28 years old
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Last activity: 9 days ago
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About me:
Loiro safado


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Buy Today For Two Months. Get The Third Month Free!
We provide the best 24/7 support
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with superior support we provide
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text:
Hi all. Im a web developer, I know my html's, my css's, my php's and very familiar with my cba's and my fuc and k's with a degree for punching monitors and tearing up reference books.
So. Im new to WordPress. I have worked with it on a job with someone else (who knows wordpress), I have had a fair bit of time playing around with it and I own a copy of the WordPress for Dummies book. Now I need to use it for a company I am working with.
What they want is a very simple news page. I am really trying to understand Pages, Posts and Categorys. I think I understand that a page is just a static page as like another web page.
As for Categorys, I just don't understand, there doesnt seem to have much options there with them.
And a post is the main conetent, posts are used to publish content.
* They want a very simple one page where it shows up news items, like an introduction into that news item with a link.
* That news item then links to a seperate page where it shows the rest of that news item.
* I would like on the first page to have all these news items listed in an archive by month. So when you click on that month it shows up all the news items in that month and year.
I have built the template myself including the rest of the site. The news page is found at http://intertech-new.eyepreview.co.uk/blog/ if you wish to look.
Can anyone help me, I just really need to know the basic and how to get started. I hav read forums, tutorials and gone through my wordpress for dummies book and it just doesnt fit. Please help. Thank you everyone, anyone who does in advance and I will thank you and discuss my progress with you along the way. Thank you.


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Written on: 07/05/2014
I regualary use Low Cost holidays to book all or part of my holiday and this year is the first time I have had to phone and email to amend the details. The first reason I had to phone was that there was an error in the booking (for some reason there was 2 hotels) and one phone call (which was answered timeously) and the fault was rectified. The second thing I had to email about was a mistake I hade made in my insurance and although the email contact was longer than expected the monies was refunded in full into my account. Well done to all concerned.Visit lowcostholidays.com
As rated by our community of reviewers
" Helpful friendly efficient " Read More
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PS4 trophy unlock animation revealed, watch it here
PlayStation 4 continues its predecessor's trophy system, and with it comes a new animation each time you unlock a gong. Watch it in .gif form here.
Posted by GearNuke, the animations look this this when compared:
What do you think? Thanks to R3Z0N for the tip.
Meanwhile, PlayStation 4's launch day firmware update – dubbed '1.50' – has been detailed by Sony. Check it out here.
Sometimes we include links to online retail stores. If you click on one and make a purchase we may receive a small commission. For more information, go here.


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Arizona Diamondbacks
Report: D-backs have interest in Rick Porcello
Another day, another trade rumor involving the Arizona Diamondbacks.
At least this one doesn't involve Justin Upton — at least not yet.
According to Fox Sports baseball scribe Jon Paul Morosi, the Diamondbacks have shown interest in Detroit Tigers right-hander Rick Porcello.
Porcello, who just turned 24 in December, already has won 48 games in four Major League seasons with the Tigers.
Last season Porcello went 10-12 for the American League champs, posting a 4.59 ERA with 107 strikeouts and 44 walks in 176.1 innings.
The Diamondbacks have unloaded some starting pitching this offseason, sending young right hander Trevor Bauer to the Cleveland Indians in a trade that secured shortstop prospect Didi Gregorius. But they still have a glut of pitchers and only five rotation spots to fill.
MLBTradeRumors.com also indicates that the Seattle Mariners have interest in dealing for Porcello.
Most Popular
D-Backs Audio
Derrick Hall, Diamondbacks president and CEO
Thursday July 28
Derrick Hall isn't making excuses, but points out all of the injuries the D-backs have faced.
Yay or Nay?
Wednesday July 27
Amar'e should be in the Suns Ring of Honor, Dave Coulier was funniest on Full House + more
Braden Shipley, D-backs rookie pitcher
Wednesday July 27
Shipley talks about the ups and downs of his Major League debut with the D-backs.
Dave Stewart - D-backs General Manager
Wednesday July 27
Stew and B-Train talk trade deadline, Chip Hale and Tony La Russa
Tony La Russa, Diamondbacks chief baseball officer
Wednesday July 27
Tony La Russa is still searching for answers to help fix the D-backs' issues.


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Star Wars: First Assault gameplay footage leaks
Leaked footage of Star Wars: First Assault has turned up, once again courtesy of Kotaku. The footage shows early gameplay footage purportedly from the fall 2012 build, as well as a video showing a pre-rendered clip. The source who sent the videos to Kotaku stated the gameplay video shows in-game footage with all known issues for the time, and that since the video's creation, "many improvements have been made in performance, completeness, and quality." First Assault is a FPS which was slated for a spring 2013 and it was originally outed in late August by a domain name and trademark registration.
Sometimes we include links to online retail stores. If you click on one and make a purchase we may receive a small commission. For more information, go here.


text:
Being a newbie who doesn't know how this process works, it is necessary for me to ask these questions;
If I (or you) were to sell the concept of a pop-up optin form on a client' website, what would the process of installing the form look like?
Is this a task for a developer, or could a person with limited coding and some WP blog building skills complete it?
If this is a coder task, how would they get access to the site in order to add the optin form?
Lots of details need to be ironed out.
Thank you for any and all replies.


text:
Toll Free: 800-354-8659 Local: 970-842-2666
Email: firstname.lastname@example.com Booking Email: firstname.lastname@example.com
The Friday night Cruise-In starts off the weekend at the Brush Grocery Kart with food and music. Saturday from 10-5 the Oktoberfest/Car Show in Downtown Brush will have approximately 100 food and craft booths, musical entertainment, dog show contest, sidewalk chalk art for the kids, car show, beer garden and polka dance in the evening from 5-9pm. This is a great family event for everyone!


text:
|By Cynthia Dunlop
Article Rating:
|April 16, 2014 11:22 AM EDT
By Noel Wurst, Managing Editor at Skytap
This article was originally published on the Skytap Blog
Noel Wurst: Hello, this is Noel Wurst with Skytap and I am speaking today with Peter Coffee. Peter is the VP for Strategic Resource at salesforce.com and he's also going to be taking part in the SDLC Acceleration Summit on May 13th in San Francisco, California. Peter how are you doing today?
Peter Coffee: It's great to be with you Noel. I'm fine, thank you.
Noel Wurst: Great, awesome. Well, I was going to say that I had the privilege of reading your bio online. I recommend listeners go online and check it out for themselves. It's such a varied background, you've done a little bit of everything. I saw everything from aerospace, the defense sector, alternative fuel research, video game development, and I was curious as to what you're working on now with Salesforce or outside of there. What's piquing your interest these days?
Peter Coffee: My job was created seven years ago at salesforce.com, three years after I had a breakfast conversation with Marc Benioff about what it would take to let people build things on the web—we didn't call it the cloud seven years ago—as readily as some of the tools like Hypercard or Visual Basic for letting them build things on desktops, and get rid of the idea that you had to build the app with all of the same complexity and difficulties and then have additional compounded difficulties putting it up online. But instead, be able to get to something that allowed you to build it as readily as if you were just going to run it on your PC, and then make it securely and reliably available to people anywhere. That was the vision for what the next generation platform needed to be. And if you think about it, the web went from being a medium where you can publish stuff for other people to read, to posting stuff on which other people could comment, to now where it really is a medium for taking what you know and packaging it in a way that makes it available for other people to use.
There was a peer research report that just came out recently that said, you've got to stop thinking of the World Wide Web as the world's library and start to think of it as the world's supercomputer.
Peter Coffee: That's really what has fascinated me in all of the areas where I've been fortunate to have the opportunity to work, is that we have tremendous facilities available to us now. Not to look at one or two isolated point ideas about what might work and then pick the one that works the least badly. But really to start mapping and entire spaces of solutions that are available to problems and really being to hunt for something close to optimality on how we get stuff done. I think that's what's really exciting in every field today, is the opportunity to pursue optimality instead of settling for incremental improvement.
Noel Wurst: It's definitely an exciting time to be in that field with all the different capabilities that are popping up day by day and month by month. I noticed that the session you're giving at the SDLC Acceleration Summit—the session or panel that you're going to speaking on is titled, "Faster In What Direction?"
Peter Coffee: Yes.
Noel Wurst: The abstract warns specifically against "accelerating a legacy model or mistaking it for progress."
Peter Coffee: Yes.
Noel Wurst: And, like you were just saying, with everything changing so much and changing so quickly, I was wondering if maybe there is an enterprise or a company that is changing quickly—what are maybe some of the warning signs that should maybe alert themselves that maybe they're not moving in the right direction? Or maybe they are changing quickly, but maybe it's not for the best.
Peter Coffee: The interesting thing about the place that's loosely called "cloud computing" is that it's very much like a supermarket in which you can walk in, and if you know what you're there to buy—it's there. If you go to the rice and beans aisle you'll find sacks of ingredients at an attractive price. And you'll take them home and you'll have to do a lot of work before you can put the food on the table. But if it occurs to you to look in another direction, well over there's the deli counter where there's some very interesting things that you might not even attempt to create yourself, that are ready for you to consume pretty much as soon as you get them home and pop them in the microwave.
That's really where the cloud marketplace is today. You've got the infrastructure cloud of virtual servers that you can spin up by the minute or the hour and do traditional skills intensive, error prone, complex and innovation limited IT at an attractive cost.
Then you've got the platform as a service and software as a service markets where you can find tremendously innovative best practices solutions available for you to use immediately and modify and tailor to become uniquely yours. I think that's the biggest caveat that I have to offer people who are attracted by the obvious economies and accelerations that virtualizing legacy IT can provide, and who think that that constitutes victory when they aren't realizing that the next logical step is to move beyond wiring up their virtual machines the way they wired up their physical ones. Instead say, "well what if I were thinking about what I do? What if I was thinking about application construction as composition and orchestration of services and the linkage at the API level, instead of composition of hardware and linkage at the binary data transfer level?"
Noel Wurst: That's a really great analogy, the "rice and beans aisle" that you said before. That's exactly what the situation is. There's all these options out there for people to change for the better, and to be able to accelerate their entire business, or the SDLC. But at the same time, it's still really difficult for people to change. Even if they see the success that other companies have had by changing and by reinventing their processes.
But I was kind of curious as to ... I know why it's hard for people to change. But what are some of the things, the reasons that those who are still maybe embracing somewhat outdated technologies. What are some of the reasons that they shouldn't fear that change? Besides just, "it'll get better" or "it's going to be great in the end." The ones where that's not enough to convince someone to make that kind of investment or make that kind of change. What are some reasons to not fear that path or completely different direction for their business?
Peter Coffee: It's perfectly logical for people who've invested years or decades in mastering a set of skills to seek reasons to believe that those skills are going to continue to be the definition of their value and the source of their livelihood to the rest of what they hope will be a healthy and lucrative career. It's completely logical for them to look for that validation. We know from any number of different research fields, that people will find confirming evidence for what they want to believe, and will be remarkably successful, even if unconsciously ignoring disconfirming evidence. So I completely get his and I don't attribute bad motives to anybody.
Noel Wurst: Right.
Peter Coffee: What I do find is that there are some organizations that are starting to look at this as much more of an opportunity to have greater leverage and to catalyze dramatic improvements. For example, I was just at the headquarters at one of our customers, USAA, which is a massive insurance company that primarily sell their services to military and ex-military. You've seen their advertising.
Their annual technology forum, their in-house event, has 3,000 people attending it. It's the size of one of our larger metropolitan events. They asked me to come and do a seminar on how the IT department could best serve, what they call, "the citizen developer"—which I believe might be a phrase that Forrester might have been the first to popularize. If you think about the way that the spreadsheet allowed people to model and experiment with a process, instead of having to go hat in hand to the business analyst, and beg for some COBOL to do that work.
It's the next logical step to go beyond the spreadsheet on a network share with an email thread wrapped around it to something like a Force.com app that runs in the cloud, has proper security, auditability, governability, back-up built in as a service, and the IT department can tremendously increase its value to the business by providing what we might call adult supervision to the citizen developer.
To provide guidance on compliance, process integrity, data dictionary discipline and so on. And the IT departments that are starting to say, "You know, tugging the old workload and keeping that to ourselves is a poor strategy for increasing our value to the organization compared to being vigorous and creative in providing support to the business units." In taking advantage of the lower barriers to entry and the considerably higher productivity they can have by building what will be a much more disciplined application.
Everyone talks about Shadow IT today. It's this dark matter of the IT universe that doesn't shine with its own light and it's very hard to find it. But we all know it's out there stretching from desktop databases and other things that are not visible, not governed, not recalled, not auditable, and not really contributing to a store of knowledge that turns the company into a learning organization. The IT departments that I think are doing very well, and there are existing groups of these, they're saying, "Our best contribution is to take things that a very difficult to learn and very easy to do wrong and still have an enduring value like basic disciplines of process integrity and find a way to sprinkle those on top of the old coffee of the legacy infrastructure and turn it into something that's much more exciting."
Noel Wurst: That's so great. It reminds me, I also had the chance to interview Theresa Lanowitz, who's also going to speaking at The SDLC Acceleration Summit, and we were talking specifically about the "extreme automation" that comes from utilizing some of these new technologies and it's like you were just saying as far as the way things were done in the past.
The definition she had of extreme automation, I asked her to define it, was "solving classic problems with new technology and tooling." Essentially saying people who are maybe of skeptical of automation, or are very quick to say, "Well automation doesn't solve everything," basically she was saying automation doesn't solve everything, but at the same time, it's not solving anything new that you haven't seen before. It's solving a problem that may have existed in your organization for years. It may have been problems that is kind of just always laid around because there wasn't extreme automation there to help solve those.
I was curious if you would maybe define extreme automation the same way or basically see the same value that it solves the problems that are well-known, well documented and widespread across multiple enterprises.
Peter Coffee: Well, I don't know if you remember, there was a minor sub-plot in the book of Jurassic Park that I think they decided was too complicated to bring forward into the movie, about how the eye of the frog doesn't even bother to tell the brain about things that aren't moving. Because the brain wants to focus on things that are moving and therefore might be targets for eating. The eye doesn't even bother to tell them about the stationary things. I think a lot of us are really good at ignoring stationary problems that have been with us for so long that we stop even to think of them even as problems and just think of them as part of the environment.
I like the phrase of "extreme automation" because it invites us to go and, pardon the expression, rip the scabs off some of those old wounds and say, "Can we afford intellectually and financially to reexamine some of our assumptions about things that we're just going to have to tolerate. Because maybe we don't have to tolerate them anymore." That can require some creativity and it can also require taking some risk. Because you're going to be bringing these ideas to senior managers who may have built their careers on the existence of these "problems" and of the construction of elaborate and complicated work arounds to these problems. And you're essentially coming in and saying, "Yeah but, what if we stopped calling that problem something that we have to tolerate at all? What if we just destroy it? What if we just cut the Gordian knot, to use another old metaphor. Instead of spending tons of effort, time, and money untangling something—we just cut it in half. That's a career risk and an intellectual challenge and a skills and technology challenge.
But there is always something going on at any given time that forces that kind of disruption. Back in the 1960s everybody was worried about the space race. So we had Project Apollo, which did some things at the time that were considered frankly impossible until people felt that they had to find a way to do them. Then they discovered ways to do it. I think our next project Apollo is the aging of the baby boomers who are going to need adaptive and assistive technology. To make it possible for them to age gracefully at home instead of going into nursing homes which we simply won't be able to afford to build at that kind of scale.
So things like a Nest thermostat are really just kind of the tip of that spear in terms of saying, "You know, we need to rethink automation from something that lets people program things to do stuff into devices and algorithms and systems that are aware of an environment, learn what's normal, call attention to that which is abnormal and therefore perhaps requires someone to do something—and that's really where we need to go with business IT as well. It's to get beyond the idea of the bigger and bigger dashboard with more and more performance indicators and get to much smarter systems that notice when things that have been behaving in a coordinated way suddenly don't seem to be coordinating. That suggests an anomaly that detects for data science disciplines what I might call "pre-failure signatures" and are able to say, "I don't know why this is happening. But I know that when it does happen, a week later something much much worse usually happens. So then you'd want to take a look at this now."
This is a very interesting time for developing new categories of algorithms that don't just capture the byproduct of business activity, but inspect those patterns and look for interesting high leverage points that allow people to take an inexpensive action at the right time instead of a much more costly disaster recovery or damage control action later on.
Noel Wurst: That's all so great. And then lastly, it's all kind of come to this. It's interesting, all of this technology we've been discussing of course involves the cloud. But I watched a video on YouTube recently of a presentation you did at PhillyForce last year that was titled "Connecting Above the Cloud."
It's funny, I'm writing an article this week about the same thing, and I'm going to use a piece of your presentation in the article. You talked about the cloud metaphor and how the industry didn't choose that term. You said that "connected" and "social" work a lot better than just saying "the cloud." To quote you from that presentation, you said, "The cloud is only interesting because of the connections that it enables."
That's really interesting, because I think we've only said the word cloud two times in this whole interview. Back in the day, "cloud" was in every other sentence. I feel like even though cloud adoption of course is going up, and all kinds of news came out this week about how it's ramping up quickly—yet, we're saying the word "cloud" less and less. I really like the way that successful enterprises have been able to enable these connections between their customers.
But I also like how much the cloud, to go ahead and say it again, has enabled developers, testers, IT, DevOps, and all this connectivity that goes on kind of behind the curtain, not just among the people who are kind of using these apps. I was kind of wondering if you might maybe expand on how this technology is helping enterprises themselves, but not just not just the consumers who use these apps.
Peter Coffee: Sure. Well, you know it's almost an accident of history that Intel had a commercial imperative to develop the integrated circuit and the microprocessor before it became practical to have a global standards-based wired and wireless network. Because we had a period of several years, a little over a decade really, when we went from the 4004 microprocessor, which was barely enough to run a four-function calculator, to things like 32bit computers on a chip.
During that time connectivity was expensive, slow, and intermittent. I compared it the other day to being colonist on Mars with our little bubbles of air and having to put on a spacesuit to go from one to another. Inside that bubble which was in the IT world, inside your data center or inside your local area network, you could be reasonably comfortable. But as soon as you wanted to do something that involved going from one bubble to another, well this was a perilous exercise. You had to use your dial-up modem or it was like putting on your spacesuit for a brief moment of interconnection with another bubble somewhere else.
During this time, we've essentially been terraforming planet computing. We've got an atmosphere now that you can breathe without putting on a spacesuit and if there's still people walking around with air tanks on their banks, that they call their "private cloud." Okay, and it doesn't make any more sense in the world of IT then it would make sense in a world of a terraformed Mars. To ignore the fact that the environment now is different. The environment is now of ubiquitous connectivity with what was comparable with what we used to find more than sufficient in an office building. You can see this in the behavior of people. They are saying, "Now wait a minute, why would I buy a laptop computer, which is essentially a spacesuit? It's its own hard drive, display, battery, keyboard all this stuff and all. All I really need is a little magic piece of black glass which might be the size of a phone or it might be the size of a tablet. All I need is that thing which is a window into this world of available information, computational capability, connection with other experts, connection with algorithms and supercomputing facilities."
There's an awful lot of stuff that used to sort of make sense to build more and more powerful desktop machines to do. But people are now saying, "But wait a minute. I don't actually want to do that on my desktop at all. I don't want to video editing on my desktop, I want to upload the clip from my smartphone to YouTube and let YouTube worry about things like compression algorithms and making it run on different devices and things like that." This is a hard challenge. It's to get beyond thinking of the cloud as a product and start thinking of the cloud as just an enabler for things that are much more interesting products.
Because if I can drag one more metaphor in, I once said, a gourmet chef does not talk about the miracle of clean water being available from a faucet whenever he needs it. He assumes that's going to be there because you can't really talk about doing cooking without it. But once you've got it, you don't really think about it very much. You don't think about the miracle of electricity when you're building your home theater. That's invisible. That's assumed and you're thinking instead about what's the amazing experience I can that create given the assumption of that pervasive reliable cost-effective resource.
It's really important to get beyond cloud and start thinking about, "Wait a minute, what do I have to do to step up my game? To be a value creator by using this medium of connection, by using processing power and algorithms of discovery and analysis, to create a kind of customer experience, or the kind of government first-response in a disaster, or the kind of life-long delivery of education that were never really feasible to discuss until we had this remarkable atmosphere in which we breathe data and breathe computational power whenever we need it."
Noel Wurst: Well, that is all I have for you today. I am really looking forward to attending your presentation at The Summit as well as the other ones that are going on there. Again, everyone, this is Peter Coffee, the VP for Strategic Research at salesforce.com. Peter speaks all over the world, and he's going to be at the SDLC Acceleration Summit in San Francisco, California on May 13th. Thank you so much for speaking with me today.
Peter Coffee: Thank you very much. I always tell people I never know what I think until I have to answer questions. So, these conversations always tell me things that I didn't realize I was thinking about until I have them. Thank you for the time.
Noel Wurst: Awesome, thank you.
DevOps at Cloud Expo – being held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real results. Among the proven benefits, DevOps is correlated with 20% faster time-to-market, 22% improvement in qua...
Jul. 30, 2016 05:45 AM EDT Reads: 2,388
"We host and fully manage cloud data services, whether we store, the data, move the data, or run analytics on the data," stated Kamal Shannak, Senior Development Manager, Cloud Data Services, IBM, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 30, 2016 05:15 AM EDT Reads: 1,470
SYS-CON Events announced today that MangoApps will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device.
Jul. 30, 2016 02:45 AM EDT Reads: 1,494
"delaPlex Software provides software outsourcing services. We have a hybrid model where we have onshore developers and project managers that we can place anywhere in the U.S. or in Europe," explained Manish Sachdeva, CEO at delaPlex Software, in this SYS-CON.tv interview at @ThingsExpo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 30, 2016 02:00 AM EDT Reads: 1,693
Predictive analytics tools monitor, report, and troubleshoot in order to make proactive decisions about the health, performance, and utilization of storage. Most enterprises combine cloud and on-premise storage, resulting in blended environments of physical, virtual, cloud, and other platforms, which justifies more sophisticated storage analytics. In his session at 18th Cloud Expo, Peter McCallum, Vice President of Datacenter Solutions at FalconStor, discussed using predictive analytics to monitor and adjust functions like performance, capacity, caching, security, optimization, uptime and se...
Jul. 30, 2016 12:30 AM EDT Reads: 2,138
Keeping pace with advancements in software delivery processes and tooling is taxing even for the most proficient organizations. Point tools, platforms, open source and the increasing adoption of private and public cloud services requires strong engineering rigor – all in the face of developer demands to use the tools of choice. As Agile has settled in as a mainstream practice, now DevOps has emerged as the next wave to improve software delivery speed and output. To make DevOps work, organizations must focus on what is most relevant to deliver value, reduce IT complexity, create more repeatable...
Jul. 30, 2016 12:30 AM EDT Reads: 2,353
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simplicity and reach of the open web.
Jul. 29, 2016 10:00 PM EDT Reads: 1,296
On Dice.com, the number of job postings asking for skill in Amazon Web Services increased 76 percent between June 2015 and June 2016. Salesforce.com saw its own skill mentions increase 37 percent, while DevOps and Cloud rose 35 percent and 28 percent, respectively. Even as they expand their presence in the cloud, companies are also looking for tech professionals who can manage projects, crunch data, and figure out how to make systems run more autonomously. Mentions of 'data science' as a skill rose 13 percent, followed by automation with 11 percent and program management with 10 percent.
Jul. 29, 2016 03:00 PM EDT Reads: 568
"delaPlex is a software development company. We do team-based outsourcing development," explained Mark Rivers, COO and Co-founder of delaPlex Software, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 29, 2016 01:00 PM EDT Reads: 2,140
Ovum, a leading technology analyst firm, has published an in-depth report, Ovum Decision Matrix: Selecting a DevOps Release Management Solution, 2016–17. The report focuses on the automation aspects of DevOps, Release Management and compares solutions from the leading vendors.
Jul. 29, 2016 12:00 PM EDT Reads: 1,847
Adding public cloud resources to an existing application can be a daunting process. The tools that you currently use to manage the software and hardware outside the cloud aren't always the best tools to efficiently grow into the cloud. All of the major configuration management tools have cloud orchestration plugins that can be leveraged, but there are also cloud-native tools that can dramatically improve the efficiency of managing your application lifecycle. In his session at 18th Cloud Expo, Alex Lovell-Troy, Director of Solutions Engineering at Pythian, presented a roadmap that can be leve...
Jul. 29, 2016 11:30 AM EDT Reads: 1,318
SYS-CON Events announced today that LeaseWeb USA, a cloud Infrastructure-as-a-Service (IaaS) provider, will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. LeaseWeb is one of the world's largest hosting brands. The company helps customers define, develop and deploy IT infrastructure tailored to their exact business needs, by combining various kinds cloud solutions.
Jul. 29, 2016 11:15 AM EDT Reads: 1,360
Deploying applications in hybrid cloud environments is hard work. Your team spends most of the time maintaining your infrastructure, configuring dev/test and production environments, and deploying applications across environments – which can be both time consuming and error prone. But what if you could automate provisioning and deployment to deliver error free environments faster? What could you do with your free time?
Jul. 29, 2016 11:00 AM EDT Reads: 457
To leverage Continuous Delivery, enterprises must consider impacts that span functional silos, as well as applications that touch older, slower moving components. Managing the many dependencies can cause slowdowns. See how to achieve continuous delivery in the enterprise.
Jul. 29, 2016 10:45 AM EDT Reads: 523
The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren't yet translating into a true "cloud" experience within the enterprise. What is stopping the growth of the "private cloud" market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, explored the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences between what is available in the public cloud and the early private clouds?
Jul. 29, 2016 09:45 AM EDT Reads: 2,166
SYS-CON Events announced today that Venafi, the Immune System for the Internet™ and the leading provider of Next Generation Trust Protection, will exhibit at @DevOpsSummit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Venafi is the Immune System for the Internet™ that protects the foundation of all cybersecurity – cryptographic keys and digital certificates – so they can't be misused by bad guys in attacks. In today's connected world, cybercriminals want to gain trusted status and remain undetected, whic...
Jul. 29, 2016 09:45 AM EDT Reads: 1,494
SYS-CON Events announced today the Kubernetes and Google Container Engine Workshop, being held November 3, 2016, in conjunction with @DevOpsSummit at 19th Cloud Expo at the Santa Clara Convention Center in Santa Clara, CA. This workshop led by Sebastian Scheele introduces participants to Kubernetes and Google Container Engine (GKE). Through a combination of instructor-led presentations, demonstrations, and hands-on labs, students learn the key concepts and practices for deploying and maintaining applications using Kubernetes.
Jul. 29, 2016 07:45 AM EDT Reads: 1,002
StackIQ has announced the release of Stacki 3.2. Stacki is an easy-to-use Linux server provisioning tool. Stacki 3.2 delivers new capabilities that simplify the automation and integration of site-specific requirements. StackIQ is the commercial entity behind this open source bare metal provisioning tool. Since the release of Stacki in June of 2015, the Stacki core team has been focused on making the Community Edition meet the needs of members of the community, adding features and value, while maintaining the StackIQ supported Pro and Enterprise editions. This release returns some focus to th...
Jul. 29, 2016 07:30 AM EDT Reads: 609
Redis is not only the fastest database, but it is the most popular among the new wave of databases running in containers. Redis speeds up just about every data interaction between your users or operational systems. In his session at 19th Cloud Expo, Dave Nielsen, Developer Advocate, Redis Labs, will share the functions and data structures used to solve everyday use cases that are driving Redis' popularity.
Jul. 29, 2016 12:30 AM EDT Reads: 1,731
In his session at @DevOpsSummit at 19th Cloud Expo, Yoseph Reuveni, Director of Software Engineering at Jet.com, will discuss Jet.com's journey into containerizing Microsoft-based technologies like C# and F# into Docker. He will talk about lessons learned and challenges faced, the Mono framework tryout and how they deployed everything into Azure cloud. Yoseph Reuveni is a technology leader with unique experience developing and running high throughput (over 1M tps) distributed systems with extremely low latency (under 10ms). He is working at Jet.com as a Director of Software Engineering leadi...
Jul. 28, 2016 10:15 PM EDT Reads: 2,258
"There's a growing demand from users for things to be faster. When you think about all the transactions or interactions users will have with your product and everything that is between those transactions and interactions - what drives us at Catchpoint Systems is the idea to measure that and to analyze it," explained Leo Vasiliou, Director of Web Performance Engineering at Catchpoint Systems, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 28, 2016 10:00 PM EDT Reads: 2,127
As companies gain momentum, the need to maintain high quality products can outstrip their development team's bandwidth for QA. Building out a large QA team (whether in-house or outsourced) can slow down development and significantly increases costs. This eBook takes QA profiles from 5 companies who successfully scaled up production without building a large QA team and includes: What to consider when choosing CI/CD tools How culture and communication can make or break implementation
Jul. 28, 2016 10:00 PM EDT Reads: 1,749
"My role is working with customers, helping them go through this digital transformation. I spend a lot of time talking to banks, big industries, manufacturers working through how they are integrating and transforming their IT platforms and moving them forward," explained William Morrish, General Manager Product Sales at Interoute, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 28, 2016 05:30 PM EDT Reads: 2,256
"We're bringing out a new application monitoring system to the DevOps space. It manages large enterprise applications that are distributed throughout a node in many enterprises and we manage them as one collective," explained Kevin Barnes, President of eCube Systems, in this SYS-CON.tv interview at DevOps at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 28, 2016 12:45 PM EDT Reads: 1,804
In today's uber-connected, consumer-centric, cloud-enabled, insights-driven, multi-device, global world, the focus of solutions has shifted from the product that is sold to the person who is buying the product or service. Enterprises have rebranded their business around the consumers of their products. The buyer is the person and the focus is not on the offering. The person is connected through multiple devices, wearables, at home, on the road, and in multiple locations, sometimes simultaneously. Products have rebranded from content management, asset management, CRM, social media, analytics .....
Jul. 28, 2016 01:15 AM EDT Reads: 933


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I would like to have the #Midori Tag. Since this browser comes with the common Raspian OS for Raspberry-Pi and there are many tutorials using #Midori . I think it makes sense to create the tag.
Meta Stack Exchange is where users like you discuss bugs, features, and support issues that affect the software powering all 158 Stack Exchange communities.
What is meta?
What is meta?
Here's how it works:
- Any Stack Exchange user can ask a question
- The community provides support, votes on ideas, and reports bugs
- Your voice helps shape the way Stack Exchange operates
Ok, I created it, midori, and a tag wiki for it, and added it to a few relevant questions. It was logical since internet-explorer, firefox and opera and others already exist.


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text:
i found a pill that is light pink, round, smooth edges, and has an imprint of R150 goin aross the top. the imprint curves with pill. does anyone know what this is. i cannot find anythng except people saying that is zantac. and i do not think this pill is.
Anyone know of a pill that is light pink with r150 on it?
- Posted:
- 25 Jul 2011 by raerae66
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