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Black Diamond 3: Lucky Chanceby Brittani Williams
Her happily-ever-after ending was just the beginning....For two years, Diamond and Black have been living comfortably on their high-class cul-de-sac with their daughter, Dior. They're ready to leave the drug business behind them, having enough money to continue their lavish lifestyle without going back to the streets to re-up. With the loss of his sister Mica, Johnny can feel nothing but rage for the woman he once loved. Now he plans to strip her of everything that she loves. From behind bars on his death bed, he sets a plan in motion that will tear Diamond's world apart. Fighting to survive, Diamond almost gives up--until a mystery man enters her life. She believes he will save the day, but is he genuine, or just another person out to teach Diamond a lesson?What would you do if your prized possessions were in danger of being taken away?
The Black Diamond Seriesby Andrea Kane
A special two-in-one edition of Andrea Kane's enchanting Black Diamond SeriesIn Legacy of the Diamond, Courtney Johnston is imprisoned aboard a privateer ship, an unwitting pawn in a nefarious scheme to snatch a rare and coveted diamond. Determined to take her revenge, the resourceful sea captain's daughter never dreams that fate will sweep her into the embrace of a dashing earl on his own desperate mission. Slayde Huntley, earl of Pembourne, will gladly barter his family's priceless gem in exchange for the return of his kidnapped sister, Aurora. But Courtney, the fiery beauty who steps onto the plank like a sea nymph, is a shock to his senses. Blindsided by passion, Slayde joins Courtney to restore what is rightfully theirs . . . even as a centuries-old legacy of murder and betrayal threatens to tear them apart forever.In The Black Diamond, Aurora Huntley would rather die than shackle herself to a man she does not love. Powerless to outwardly defy her brother's decree for her marriage, the unconventional noblewoman devises a wickedly outrageous plan. But her scheme backfires when she conspires with a charismatic stranger to orchestrate her fall from grace . . . and learns who her lover-to-be really is. Julian Bencroft, the new duke of Morland, did not know that he would share a soul-stirring kiss with Aurora Huntley when he agreed to help her free herself from an arranged marriage. Now he is sworn to combat the long shadow of the diamond that has cursed her family for generations. As he and Aurora embark on a quest for the priceless gem, they plunge into a hotbed of intrigue and deception . . . and realize how much they'll risk for a love beyond price.
Black Diamond: The Story of the Negro Baseball Leaguesby Patricia C. Mckissack Fredrick Mckissack
A stirring tribute to the human drama, legendary heroes, infamous owners, low pay, and long bus rides that were the Negro Leagues. A 1995 Coretta Scott King Honor Book now in a striking Polaris edition. Copyright © Libri GmbH. All rights reserved.
Black Diamondsby Catherine Bailey
From the New York Times-bestselling author of The Secret Rooms, the extraordinary true story of the downfall of one of England's wealthiest familiesFans of Downton Abbey now have a go-to resource for fascinating, real-life stories of the spectacular lives led by England's aristocrats. With the novelistic flair and knack for historical detail Catherine Bailey displayed in her New York Times bestseller The Secret Rooms, Black Diamonds provides a page-turning chronicle of the Fitzwilliam coal-mining dynasty and their breathtaking Wentworth estate, the largest private home in England.When the sixth Earl Fitzwilliam died in 1902, he left behind the second largest estate in twentieth-century England, valued at more than £3 billion of today's money--a lifeline to the tens of thousands of people who worked either in the family's coal mines or on their expansive estate. The earl also left behind four sons, and the family line seemed assured. But was it? As Bailey retraces the Fitzwilliam family history, she uncovers a legacy riddled with bitter feuds, scandals (including Peter Fitzwilliam's ill-fated affair with American heiress Kick Kennedy), and civil unrest as the conflict between the coal industry and its miners came to a head. Once again, Bailey has written an irresistible and brilliant narrative history.
Black Directors in Hollywoodby Melvin Donalson
This book offers a first comprehensive look at the work of black directors in Hollywood, from pioneers such as Gordon Parks, Melvin Van Peebles, and Ossie Davis to current talents including Spike Lee, John Singleton, Kasi Lemmons, and Carl Franklin. Discussing 67 individuals and over 135 films, Melvin Donalson thoroughly explores how black directors' storytelling skills and film techniques have widened both the thematic focus and visual style of American cinema. Assessing the meanings and messages in their films, he convincingly demonstrates that black directors are balancing Hollywood's demand for box office success with artistic achievement and responsibility to ethnic, cultural, and gender issues.
Black Dogby Rachel Neumeier
BLACK DOG by Rachel Neumeier takes the reader into a hidden world of magic, war, and shapeshifting that exists just behind the headlines of the human world. Think of it as Robin McKinley's SUNSHINE but with werewolves instead of vampires.Natividad is Pure, one of the rare girls born able to wield magic. Pure magic can protect humans against the supernatural evils they only half-acknowledge--the blood kin or the black dogs. In rare cases--like for Natividad's father and older brother--Pure magic can help black dogs find the strength to control their dark powers. But before Natividad's mother can finish teaching her magic their enemies find them. Their entire village in the remote hills of Mexico is slaughtered by black dogs. Their parents die protecting them. Natividad and her brothers must flee across a strange country to the only possible shelter: the infamous black dogs of Dimilioc, who have sworn to protect the Pure. In the snowy forests of Vermont they are discovered by Ezekiel Korte, despite his youth the strongest black dog at Dimilioc and the appointed pack executioner. Intrigued by Natividad he takes them to Dimilioc instead of killing them.Now they must pass the tests of the Dimilioc Master. Alejandro must prove he can learn loyalty and control even without his sister's Pure magic. Natividad's twin Miguel must prove that an ordinary human can be more than a burden to be protected. And even at Dimilioc a Pure girl like Natividad cannot remain unclaimed to cause fighting and distraction. If she is to stay she must choose a black dog mate. But, first, they must all survive the looming battle.
Black Dogby Caitlin Kittredge
Ava has spent the last hundred years as a hellhound, the indentured servant of a reaper who hunts errant souls and sends them to hell. When a human necro- mancer convinces her to steal her reaper's scythe, Ava incurs the wrath of the demon Lilith. As punishment, Lilith orders Ava to track down the last soul in her reaper's ledger--or die trying.But after a hundred years of servitude, it's time for payback. And hell hath no fury like an avenging Ava. . . .
The Black Dog Mysteryby Ellery Queen Jr. Jr.
A gang of young sleuths and a trusty terrier put their noses to a bank robbers' trail Ellery Queen's young apprentice, Djuna, is preparing for an afternoon of fishing when a stranger leans out of his car window and asks for directions to Canada. A few minutes later, Djuna watches as the man's friends come running out of the local bank and into the getaway car, guns blazing, before taking off for the Canadian border. It is a mystery that could baffle even Djuna's famous boss, but with the help of a ferocious black Scottie named Champ and a few crime-solving friends, he will find the culprits. It will be the greatest adventure of his life. Ellery Queen is one of the world's finest detectives, but his adventures are nothing compared to the Ellery Queen Jr. Mystery Stories. Join Queen's apprentice, Djuna, and his trusty Scottie, Champ, on adventures filled with danger, suspense, and thrills.
Black Dog Summerby Miranda Sherry
In this extraordinary debut novel reminiscent of The Lovely Bones and Little Bee, a mother watches from the afterlife as her teenage daughter recovers amidst the startling dysfunction of her extended family.A small, bright thread of a story weaves out from the moment of my passing and seems to tether me to this place. Perhaps this is why I have not left yet. Perhaps I have no choice but to follow the story to its end. Compulsively readable and stylistically stunning, Black Dog Summer begins with a murder, a farmstead massacre, in the South African bush. Thirty-eight-year-old Sally is but one of the victims. Her life brutally cut short, she narrates from her vantage point in the afterlife and watches as her sister, Adele, her brother-in-law and unrequited love Liam, her niece Bryony, and her teenage daughter, Gigi, begin to make sense of the tragedy. A suspenseful drama focusing on marriage and fidelity, sisterhood, and the fractious bond between mothers and daughters, Black Dog Summer asks: In the wake of tragedy, where does all that dark energy linger? The youngest characters, Bryony and Gigi, cousins who are now brought together after Sally's murder, are forced into sharing a bedroom. Bryony becomes confused and frightened by the violent energy stirred up and awakened by the massacre, while Gigi is unable to see beyond her deep grief and guilt. But they are not the only ones aware of the lurking darkness. Next door lives Lesedi, a reluctant witchdoctor who hides her mystical connection with the dead behind the façade of their affluent Johannesburg suburb. As Gigi finally begins to emerge from her grief, the fragile healing process is derailed when she receives some shattering news, and in a mistaken effort to protect her cousin, puts Bryony's life in imminent danger. Now Sally must find a way to prevent her daughter from making a mistake that could destroy the lives of all who are left behind. Gorgeously written, with a pace that will leave readers breathless, Black Dog Summer introduces a brilliant new voice in fiction.
The Black Dog Summer on the Vineyard Cookbookby Joe Hall Elaine Sullivan
Over the past thirty years, The Black Dog Tavern has grown from a small island haunt to a nationally renowned restaurant. Its astonishingly successful local store and nationwide mail order business have spread the famous black lab logo around the world. No trip to the Vineyard, by presidents, movie stars, or ordinary folk, is complete without a meal at The Black Dog. Until now there has been no way to enjoy such Black Dog classics as a Huey, Louie, Quahog or Fish Chowder; or Fudge Bottom Pie without going to the Vineyard.
Black Dogsby Ian Mcewan
In 1946, a young couple set off on their honeymoon. Fired by their ideals and passion for one another, they plan an idyllic holiday, only to encounter an experience of darkness so terrifying it alters their lives forever. In this highly praised national bestseller, Ian McEwan has written his most humane and compelling novel to date.From the Hardcover edition.
The Black Doorby Collin Wilcox
A crime reporter with ESP tackles a double homicideIn a San Francisco apartment building, a young woman is found strangled beside a piano player with a broken neck. He's a nobody--a dreamer with little talent and no future--but she is Roberta Grinnel, daughter of one of the wealthiest men in the Bay Area. Stephen Drake, crime reporter for the Sentinel, feels nothing when he looks at their corpses, and this is a troubling fact. For Drake is a psychic, and when his sixth sense fails him, that means more trouble ahead.As Drake tries to come to grips with his cosmic gift, the mystery of the heiress and the piano player becomes the hottest story in town. To keep his gig at the paper, Drake will call on every source he has--on this plane and the astral one--but knowing danger's lurking doesn't guarantee he can stay out of its way.
The Black Doveby Steve Hockensmith
In the summer of 1893, Gustav "Old Red" Amlingmeyer and his brother Otto (a.k.a. "Big Red") find themselves down and out in San Francisco. Though cowpokes by training, the brothers are devotees of the late, great Sherlock Holmes and his trademark method of "deducifying." But when they set out to land jobs as professional detectives, they land themselves in hot water, instead. First their friend Dr. Chan mysteriously takes a potshot at them, fatally wounding Big Red's new hat. Then a secretive young woman from their past pops up and convinces them that Chan's in trouble -- and they're just the men to get him out of it. Unfortunately, they're too late: By the time they track Chan down again, he's dead. The police call it a suicide. Old Red calls that a lie. When he and his brother set out to prove it, they put themselves on a collision course with shady S.F.P.D. cops, brutal Barbary Coast hoodlums and the deadly Chinatown tongs. Before long, all sides are in a race to uncover the secret that could rock the city. And their only clue to what's actually going on is the enigmatic, exotic and extremely difficult to find "Black Dove."
The Black Dragon (Tom Swift, #1)by Victor Appleton
The young inventor Tom Swift loses his flying skyboard to Xavier Mace, aka The Black Dragon, an elusive evil genius. Swift must get the board back.
Black Dreams (Theresa Fortunato #2)by Kate Green
Psychic Theresa Fortunato helps LAPD Lieutenant Oliver Jardine track down a missing child and solve a murder in their second novel.
Black Duckby Janet Taylor Lisle
It is spring 1929, and Prohibition is in full swing. So when Ruben and Jeddy find a dead body washed up on the shore of their small coastal Rhode Island town, they are sure it has something to do with smuggling liquor. Soon the boys, along with Jeddy's strongwilled sister, Marina, are drawn in, suspected by rival bootlegging gangs of taking something crucial off the dead man. Then Ruben meets the daring captain of the Black Duck, the most elusive smuggling craft of them all, and it isn't long before he's caught in a war between two of the most dangerous prohibition gangs.
Black Eagleby Charles G. West
When old-timer scout Jason Coles ended the rampage of renegade Cheyenne Stone Hand, he quit tracking outlaws for the army for good. Settling down with his wife and newborn baby, Coles plans to spend the rest of his days on his ranch raising horses. But that dream is savagely torn from him as his ranch is burned to the ground, and his family is abducted by the bloodthirsty Cheyenne Little Claw, out to avenge the death of Stone Hand! With the lives of his family at stake, Coles must once again strap on his revolvers to hunt a merciless killer!
Black Eagle Childby Ray Young Bear
Mixing prose and poetry, ancient traditions and modern sensibilities, this brilliant, profane, and poignant coming-of-age story is a masterpiece of Native American literature At a Thanksgiving party held in a Bureau of Indian Affairs gymnasium, the elders of the Meskwaki Settlement in central Iowa sip coffee while the teenagers plot their escape. Edgar Bearchild and Ted Facepaint, too broke to join their friends for a night of drinking in a nearby farm town, decide to attend a ceremonial gathering of the Well-Off Man Church, a tribal sect with hallucinogenic practices. After partaking of the congregation's sacred star medicine, Edgar receives a prophetic vision and comes to a newfound understanding of his people's past and present that will ultimately reshape the course of his life. Set against the backdrop of the tumultuous 1960s, Black Eagle Child is the story of Edgar's passage from boyhood to manhood, from his youthful misadventures with Ted, to his year at prestigious liberal arts college in California, to his return to Iowa and success as a poet. Deftly crossing genre boundaries and weaving together a multitude of tones and images--from grief to humor, grape Jell-O to supernatural strobe lights--it is also an unforgettable portrait of what it means to be a Native American in the modern world.
Black Eagle Risingby Kate Jacoby
Black Eagle Rising is the third book in Kate Jacoby's epic fantasy series, the Books of Elita.
Black Eagle Rising (The Books of Elita)by Kate Jacoby
The latest episode in this lush romantic fantasy epic. The evil sorcerer Nash is recovered from the injuries he sustained when Robert Douglas, Duke of Haddon & named as the Enemy, levelled Elita with his magic. Now Nash is closer to the Key, the Word of Destruction & unlimited power than ever before, with only a tortured man & a headstrong woman standing between him & his ultimate ambition: complete possession of Lusara - & the Ally, Jenn.
Black Earth: A Journey Through Russia After the Fallby Andrew Meier
"That Black Earth is an extraordinary work is, for anyone who has known Russia, beyond question."--George Kennan "A compassionate glimpse into the extremes where the new Russia meets the old," writes Robert Legvold (Foreign Affairs) about Andrew Meier's enthralling new work. Journeying across a resurgent and reputedly free land, Meier has produced a virtuosic mix of nuanced history, lyric travelogue, and unflinching reportage. Throughout, Meier captures the country's present limbo--a land rich in potential but on the brink of staggering back into tyranny--in an account that is by turns heartrending and celebratory, comic and terrifying. A 2003 New York Public Library Book to Remember. "Black Earth is the best investigation of post-Soviet Russia since David Remnick's Resurrection. Andrew Meier is a truly penetrating eyewitness."--Robert Conquest, author of The Great Terror; "If President Bush were to read only the chapters regarding Chechnya in Meier's Black Earth, he would gain a priceless education about Putin's Russia."--Zbigniew Brzezinski "Even after the fall of Communism, most American reporting on Russia often goes no further than who's in and who's out in the Kremlin and the business oligarchy. Andrew Meier's Russia reaches far beyond . . . this Russia is one where, as Meier says, history has a hard time hiding. Readers could not easily find a livelier or more insightful guide."--Adam Hochschild, author of King Leopold's Ghost and The Unquiet Ghost: Russians Remember Stalin "From the pointless war in Chechnya to the wild, exhilarating, and dispiriting East and the rise of Vladimir Putin, the former KGB officer--it's all here in great detail, written in the layers the story deserves, with insight, passion, and genuine affection."--Michael Specter, staff writer, The New Yorker; co-chief, The New York Times Moscow Bureau, 1995-98. "[Meier's] knowledge of the country and his abiding love for its people stands out on every page of this book....But it is his linguistic fluency, in particular, which enables Mr. Meier to dig so deeply into Russia's black earth."--The Economist "A wonderful travelogue that depicts the Russian people yet again trying to build a new life without really changing their old one."--William Taubman, The New York Times Book Review.
The Black Echo (Harry Bosch #1)by Michael Connelly
For LAPD homicide cop Harry Bosch -- hero, maverick, nighthawk -- the body in the drainpipe at Mulholland Dam is more than another anonymous statistic. This one is personal.The dead man, Billy Meadows, was a fellow Vietnam "tunnel rat" who fought side by side with him in a nightmare underground war that brought them to the depths of hell. Now, Bosch is about to relive the horror of Nam. From a dangerous maze of blind alleys to a daring criminal heist beneath the city to the tortuous link that must be uncovered, his survival instincts will once again be tested to their limit.Joining with an enigmatic and seductive female FBI agent, pitted against enemies inside his own department, Bosch must make the agonizing choice between justice and vengeance, as he tracks down a killer whose true face will shock him.
Black Elk Speaks: Being the Life Story of a Holy Man of the Oglala Siouxby John G. Neihardt
The most famous Native American book ever written, Black Elk Speaks is the acclaimed story of Lakota visionary and healer Nicholas Black Elk (1863-1950) and his people during the momentous, twilight years of the nineteenth century. Black Elk grew up in a time when white settlers were invading the Lakotas' homeland, decimating buffalo herds and threatening to extinguish their way of life. Black Elk and other Lakotas fought back, a dogged resistance that resulted in a remarkable victory at the Little Bighorn and an unspeakable tragedy at Wounded Knee. Beautifully told through the celebrated poet and writer John G. Neihardt, Black Elk Speaks offers much more than a life story. Black Elk's profound and arresting religious visions of the unity of humanity and the world around him have transformed his account into a venerated spiritual classic. Whether appreciated as a collaborative autobiography, a history of a Native American nation, or an enduring spiritual testament for all humankind, Black Elk Speaks is unforgettable. This special edition features all three prefaces to Black Elk Speaks that John G. Neihardt wrote at different points in his life, a map of Black Elk's world, a reset text with Lakota words reproduced using the latest orthographic standards, and color paintings by Lakota artist Standing Bear that have not been widely available for decades.
Black Elk Speaks: Being the Life Story of a Holy Man of the Oglala Sioux (Premier Edition)by John G. Neihardt
Black Elk Speaks is widely hailed as a religious classic, one of the best spiritual books of the modern era and the bestselling book of all time by an American Indian. This inspirational and unfailingly powerful story reveals the life and visions of the Lakota healer Nicholas Black Elk (1863-1950) and the tragic history of his Sioux people during the epic closing decades of the Old West. In 1930, the aging Black Elk met a kindred spirit, the famed poet, writer, and critic John G. Neihardt (1881-1973) on the Pine Ridge Reservation in South Dakota. The Lakota elder chose Neihardt to share his visions and life with the world. Neihardt understood and today Black Elk is known to all.
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Most Recent Articles In Advertising
Latest Advertising Articles
- Kate Spade New York Creates Celebrity-Filled Cabaret With Fall Campaign [Premium]
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Eileen Fisher's clothing has always had a story to tell, and now the company is getting the word out through its fall ad campaign.
Fifty percent of its print ads will carry an ampersand symbol, which signals that the brand has more information about the sustainable choices behind the clothing in the images. In past campaigns, Fisher featured simple and graphic images, without copy. Fisher believes that the graphic symbol enables the firm to call out the sustainable efforts it is making, such as a partnership with an artisan in Spain who dyes glovelettes using ingredients from her garden, as well as using silks that meet the strict and holistic Bluesign standard.
This story first appeared in the July 16, 2012 issue of WWD. Subscribe Today.
One ad, for example, shows a model wearing an outfit and below the ampersand is the following description: "The fair-trade sweater. From Peru, organic cotton that skips the chemicals, relying instead on age-old practices: crop rotation, beneficial bugs and the wisdom of farmers." The ad refers customers to the dedicated microsite, eileenfisher.com/ampersand, for more information.
At present, 25 percent of Fisher's collection is sustainable, including using fair-trade organic cotton knits; silks that are Bluesign certified for eco dyeing, and organic, sustainable and recycled fibers and dye processes. Some 800,000 units are made in New York City. The company supports traditional crafts and cultures throughout the world.
The ampersand campaign will appear in magazines such as Vogue, InStyle, Vanity Fair and The New York Times' Thursday and Sunday Style sections and the Magazine, as well as Dwell, Fast Company and the New Yorker. Supplementing the print ads will be a digital campaign that will appear on Macy's Vision Billboard, a full-motion digital video billboard that wraps around the corner of 34th Street and Seventh Avenue, in September; the microsite, eileenfisher.com/ampersand with in-depth articles, features and videos describing their sustainable initiatives, an in-store newspaper that will enable customers to read articles and an interview with Fisher on "Business as a Movement," and various activities on social media platforms such as Twitter and Facebook.
The idea for the multifaceted campaign came from Fisher's creative agency, Bone & Black, with whom they partner on creative direction for the company. The photographer is Martin Bone, creative director of Bone & Black. The models featured in the campaign are Natalia Costa, Cerelina Proesl, Jihae Kim and Varsha Thapa.
Fisher will spend less than $2 million on its media budget for fall, which is a double-digit increase from last fall's spend. The campaign will also run in London, where Eileen Fisher has two stores. The budget doesn't include the microsite or in-store newspaper.
The company plans an event on Sept. 22 at all 58 Eileen Fisher stores. It will highlight the brand's mission to empower women and girls, and the company will donate 10 percent of proceeds to community non-profits that support leadership in women and girls. Ongoing efforts also include hangtags that have a behind-the-label checklist so customers can see whether a garment has sustainable fibers, certified dyeing or a Made in USA label, as well as in-store signage and visual window displays.

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Original Language: Hebrew
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If you have any interest in the Israeli Defense Force, or about Yonatan Netanyahu, this book is a must read. Read morePublished on September 27, 2012 by CurbMyEnthusiasm
I thoroughly enjoyed reading this book. You felt part of Jonathan's life through his letters. It shows the seriousness of the situation Israel faces daily and shows the patriotism... Read morePublished on July 1, 2012 by Edith A. Todd
An incredible literary work, by the man's own pen no less. A must read for all, by virtue of the undeniable character of Jonathan Netanyahu. Read morePublished on December 22, 2010 by A lesser Jonathan
Self-Portrait of a Hero: The Letters of Jonathan Netanyahu (1963-1976)
With an Introduction and Afterword by Benjamin and Iddo Netanyahu
After reading A Voice... Read more


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Bard Music Festival Displays 'Puccini and His World' To The Public
ANNANDALE-ON-HUDSON, N.Y. -- Giacomo Puccini and His World, the 27th installment of the acclaimed critically acclaimed Bard Music Festival, opens Friday, Aug. 5 with performances of Weeke...Read More
Pucker Up For National Lipstick Day, Bronxville
MAMARONECK, N.Y. -- Get your pout ready to pucker up. Friday, July 29 is National Lipstick Day, which lead us to Heather Adessa, a New Rochelle resident and owner of Glo Beauty Bar in Mam...Read More
Raise A Glass To Summer With 'Cool' Ideas From Westchester Wine Shop
RYE, N.Y. -- What wines go with summer? Cai Palmer, owner of Rye's Wine at Five which prides itself on its affordable and eclectic vino varieties, offers the following suggestions. A Los ...Read More
Walter's In Mamaroneck Snags Win In 'DVlicious Hot Dog Contest'
MAMARONECK, N.Y. -- Walter's in Mamaroneck, a longtime Westchester institution, won our "DVlicious Best Hot Dogs in Westchester County" contest. The roadside stand, profiled earlier HERE,...Read More
Reinvent Your Coffee Experience With Westchester's Cold Brew Options
WESTCHESTER COUNTY, N.Y. -- Ready to cool down with something hot? This summer, getting caffeinated is all about cold-brew, a centuries-old method that offers Westchester residents fresh ...Read More
Westchester Named One Of Nation's Top Digital Counties
The Center for Digital Government and the National Association of Counties have named Westchester County one of the top 10 digital counties in the United States for the fourth consecutive...Read More
Priyanka Chopra Shoots 'Quantico' Scenes In Westchester
TARRYTOWN, N.Y. -- Talk about sweet. Actress Priyanka Chopra was spotted filming ABC's "Quantico" just outside Main Street Sweets in Tarrytown. The show, whose second season is scheduled ...Read More


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Ettore Majorana Foundation and Centre for Scientific Culture
President: Professor Antonino Zichichi
Director: Sir Tom Blundell, FRS FMedSci
University of Oxford, UK
Griffith University
Brisbane, AU
Professor Jennifer L Martin is the newly appointed Director of the Eskitis Institute at Griffith University in Australia. Jenny trained as a pharmacist in Melbourne, Australia, and was the Gold Medallist of her year at the Victorian College of Pharmacy. She was subsequently awarded a Royal Commission for the Exhibition of 1851 Science Research Scholarship to undertake a DPhil research degree at the University of Oxford, in protein crystallography and structure-based inhibitor design. She established her own lab at the University of Queensland just 3 years after her PhD was awarded, in the Centre for Drug Design and Development, with a move 10 years later to the Institute for Molecular Bioscience. Her research focuses on protein structure and function in health and disease and the application of structure-based approaches to develop new drugs. Jenny is Vice-President of the Asian Crystallography Association, a former President of the Society of Crystallographers in Australia and New Zealand, and a former chair of the National Committee for Crystallography of the Australian Academy of Science. She is a strong advocate for gender equity, a member of the Australian NHMRC Women in Health Science Committee, and a founding member of the Science in Australia Gender Equity (SAGE) Steering Committee for the Academy of Science. SAGE recently launched an Australian pilot of the UK Athena SWAN awards program for gender equity in STEMM. Jenny is the recipient of many awards including an inaugural ARC Australian Laureate Fellowship, the ASBMB Roche Medal, the Queensland Smart Women Smart State Research Scientist Award, and the Women in Biotech Outstanding Achievement Award.
Rising Star Sessionmore info
30 November 2016
Over the last 50 years, crystallography has developed from a method capable of determining the structures of isolated, soluble proteins to one able to provide detailed information on mechanisms of action of integral membrane proteins, whole viruses and the complex nano-machines that are central to cellular function. To discover how biology works researchers are now combining the power of crystallography with multiple other methods, spanning from the atomic to cellular scale, and including revolutionary developments in electron cryo-microscopy and tomography. This Course will celebrate its milestone as the 50th in the crystallography series started by Dorothy Hodgkin by focusing on integration: 1) of different techniques, 2) of molecular and cellular approaches and 3) of the crystallographic community, including diversity.
The aim is to provide young researchers with a review of the fundamental approaches and latest developments in the application of crystallography and hybrid methods to the structure and function of biological macromolecules and complexes. Lectures will exemplify use of integrated approaches to analyse molecular mechanism in human and pathogen biology. There will be hands-on workshops to provide practical experience and in-depth discussion of topics ranging from sample preparation to data analysis software. To commemorate the achievements of the Erice crystallography school over the past 50 years, the course will feature several sessions that reflect on the past and look to the future to highlight the factors that create an inclusive discipline.
New for the 50th Erice School in 2017 is the Rising Star session featuring young crystallographers from around the globe speaking about their research.
Tick the box on the registration form if you're eligible for a Rising Star Award (current PhD student or PhD awarded after Dec 31 2013) and would like to be considered.
ETH, Zuerich, CH
LMB, Cambridge, UK
Caltec, Pasadena, US
Dr. Bjorkman received a B.A. degree in Chemistry from the University of Oregon and a Ph.D. degree in Biochemistry from Harvard University. As a graduate student and postdoctoral fellow in Don Wiley's laboratory, she solved the first crystal structure of a human histocompatibility complex molecule. She continued her postdoctoral training at Stanford with Mark Davis, where she worked on T cell receptors. She joined the faculty of Caltech in 1989. Dr. Bjorkman is a member of the US National Academy of Sciences, the American Academy of Arts and Sciences, the American Philosophical Society, and is a Fellow of the American Association for the Advancement of Science. She was the L'OREAL-UNESCO Women in Science North American Laureate (2006) and was named Among Most Powerful Moms in STEM (Science, Technology, Engineering, and Math) in Working Mother magazine (2011).
Dr. Bjorkman's laboratory is interested in immune recognition of viral pathogens. We are particularly interested in understanding the immune response against HIV-1 and influenza in order to develop improved therapeutics. We use X-ray crystallography, electron microscopy, and biochemistry to study pathogen envelope glycoproteins and host immune response proteins. Using structural information and alternate antibody architectures, we are engineering antibody-based reagents with increased potency and breadth. We are also investigating the structural correlates of broad and potent antibody-mediated neutralization of HIV-1 to better understand what leads to naturally-occurring broad and potent antibodies. In related work, we use 3D imaging techniques such as electron tomography and fluorescent microscopy to investigate HIV/SIV infection in animal and human tissues.
NYSBC, New York, US
Bridget Carragher received her Ph.D. in Biophysics from the University of Chicago in 1987. She then worked in a variety of positions, both in industry and academia until moving to the Scripps Research Institute in 2001. Since 2002 she has served as the Director of the National Resource for Automated Molecular Microscopy (NRAMM), an NIH funded national biotechnology research resource. The focus of NRAMM is the development of automated imaging techniques for solving three-dimensional structures of macromolecular complexes using cryo-transmission electron microscopy (cryoEM). The overall goal is to develop new methods to improve the entire process, from specimen preparation to the generation of the final three-dimensional map. In 2007 Bridget co-founded a new company, NanoImaging Services, Inc., whose goal is to provide cryoEM and other microscopy services to the biopharmaceutical and biotechnology industry. She serves as Chief Operations Officer of NanoImaging Services. In 2015 Bridget moved her academic lab from The Scripps Research Institute to the New York Structural Biology Center where she now serves as Co-Director of the Simons Electron Microscopy Center.
Baylor College of Medicine, Houston, TX, US
Wah Chiu received his BA in Physics (1969) and PhD in Biophysics (1975) from the University of California, Berkeley. He is the Alvin Romansky Professor of Biochemistry and the Director of the National Center for Macromolecular Imaging at Baylor College of Medicine in Houston, Texas. He is a pioneer in methodology development for electron cryo-microscopy. His work has made multiple transformational contributions in developing single particle electron cryo-microscopy as a tool for the structural determination of molecular machines at atomic resolution.
His research, collaboration and training activities in structural and computational biology have been recognized by his elected membership to the Academia Sinica, Taiwan (2008) and the United States National Academy of Sciences (2012) in addition to several honors including the Distinguished Science Award from the Microscopy Society of America (2014), Honorary Doctorate of Philosophy, University of Helsinki, Finland (2014) and the Barbara and Corbin J. Robertson Jr. Presidential Award for Excellence in Education, Baylor College of Medicine (2015).
MPI for Biochemistry, Munich, DE
Elena Conti studied chemistry at the University of Pavia in Italy and received her Ph.D. in 1996 from the Faculty of Physical Sciences at Imperial College in London. For her post-doctoral studies, Conti joined the laboratory of John Kuriyan at the Rockefeller University in New York, where she worked on the mechanisms of nuclear protein import. In 1999, she established her own research group at the European Molecular Biology Laboratory in Heidelberg. In 2007, Conti became Director and Scientific Member of the Max Planck Institute of Biochemistry in Munich, where she heads the department of Structural Cell Biology. Conti's research is aimed at understanding how RNA export, surveillance and turnover are carried out by the concerted action of macromolecular machines using a combination of structural biology, biochemistry and biophysical approaches. In particular, her group has studied the mechanisms of mRNA surveillance centered at the exon junction complex and of RNA degradation by the exosome complex. In recognition of her work, Conti has been elected member of EMBO and of the Germany Academy of Science in 2009 and has been awarded several prizes, including the Leibniz Prize in 2008 and the Jeantet Prize for Medicine in 2014.
MRC, Cambridge, UK
I have studied molecular biology and structural biology at the University of Tuebingen, Technical University of Munich and Paul Scherrer Institute (CH). Following that, I started a PhD in the group of Prof. Henry Chapman at DESY in Hamburg (D). The main focus of my thesis was the development of the serial femtosecond crystallography approach at modern X-ray sources. Besides methodological developments, I was heavily involved in G-protein coupled receptor structural biology. In addition, I have adapted the serial crystallography approach to a synchrotron light source, which made this approach applicable to a wider community of structural biologists. In 2015, I graduated with summa cum laude in Chemistry at the University of Hamburg. After my PhD I was awarded with an HFSP long-term fellowship to join the laboratory of Dr. Sjors Scheres at the LMB, Cambridge (UK). The main focus of our group is methodological developments in the field of single particle cryoEM with a main focus on computational aspects.
Utrecht University, NL
Harvard University, Boston, US
Dr. Hur received her BS in physics from Ewha Women's University in Korea in 2001, Ph.D. in physical chemistry with Dr. Thomas C. Bruice at the University of California, Santa Barbara in 2003, and post-doctoral training in X-ray crystallography with Dr. Robert M. Stroud at the University of California, San Francisco. Dr. Hur joined Harvard Medical School in 2008 as an assistant professor in Dept. of Biological Chemistry and Molecular Pharmacology. In 2014, she was promoted to an associate professor with a joint appointment at Boston Children's Hospital. Dr. Hur is a recipient of the 2009 Massachusetts Life Sciences Young Investigator Award, the 2010 Pew Scholar Award, the 2015 Vilcek Prize for Creative Promise in Biomedical Science and the 2015 Burroughs Wellcome Infectious Disease Investigator Award.
Dr. Hur's research focuses on structural and biochemical mechanisms of the immune system. Over the past several years, she and her research group have identified the mechanism by which the innate immune system distinguishes between self and non-self RNAs. In particular, the group has discovered the filamentous assembly architecture of the viral RNA sensors, MDA5 and RIG-I, and how the assembly structures and their dynamics are utilized for viral RNA detection and activation of the antiviral signaling pathway. More recently, Dr. Hur's interest has expanded to a group of transcription factors that are involved in self vs. non-self discrimination in the adaptive immune system. These include AIRE and FOXP3 that play critical roles in eliminating or suppressing auto-reactive T cells.
MPI for Biophysics, Frankfurt, DE
Werner Kühlbrandt studied chemistry and crystallography at the Free University Berlin, and biochemistry and biophysics at King's College London. He did his PhD with Nigel Unwin at the MRC Laboratory of Molecular Biology in Cambridge, UK, investigating the structure of two-dimensional ribosome crystals by electron microscopy. As a postdoc, he turned to structural studies of membrane proteins, first at the ETH Zürich, and then at Imperial College London, to determine the high-resolution structure of the plant light-harvesting complex, LHC-II. After a short stay at UC Berkeley, CA, he became a group leader at EMBL Heidelberg in 1988, where he solved the cryoEM structure of LHC-II at 3.4 Å resolution. Since 1997 he is a director at the Max Planck Institute of Biophysics in Frankfurt, Germany. His department of Structural Biology investigates the structure and function of membrane transport proteins by X-ray or electron crystallography, and the structure of large membrane protein complexes, such as the mitochondrial ATP synthase, by single-particle cryoEM and electron tomography.
University of California at Berkeley, US
Dr. Kuriyan earned his PhD in 1986 from the Massachusetts Institute of Technology. He was a post-doctoral fellow with Professors Martin Karplus (Harvard) and Gregory A. Petsko (MIT). From 1987 to 2001 he was on the faculty of The Rockefeller University, New York, where he was promoted to full Professor in 1993. He is a Professor of Molecular and Cell Biology and also of Chemistry at the University of California, Berkeley, a position he has held since 2001. Dr. Kuriyan is also an investigator of the Howard Hughes Medical Institute, having been appointed in 1990.
Dr. Kuriyan's research concerns the atomic-level structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling, as well as biochemical, biophysical, and cell biological analyses to elucidate mechanisms. Breakthroughs from the lab have included determining the auto-inhibited structures of several tyrosine kinases, including Src family kinases and elucidating the mechanism of allosteric activation of the kinase domains of the EGF receptor. His laboratory has provided a fundamental understanding of the structure and regulation several other signaling proteins, including STATs, the Ras activator SOS, and calcium/calmodulin-dependent protein kinase-II. Their structural insights have helped understand how the misregulation of these enzymes is often coupled to cancer and immune diseases and has implications for the development of kinase-targeted drugs to treat these diseases. His lab has also made fundamental contributions to understanding the structural basis for high-speed DNA replication. Dr. Kuriyan's achievements in science have been recognized by numerous honors:
Foreign Member of The Royal Society, London. Elected April 2015.
Doctor of Humane Letters, honoris causa, Juniata College, Huntington, PA. May 2014. Merck Award, American Society of Biochemistry and Molecular Biology, 2009.
Fellow, American Academy of Arts and Sciences, Elected 2008.
Richard Lounsbery Award, US National Academy of Sciences, 2005.
Member, US National Academy of Sciences, Elected 2001.
Cornelius Rhoads Memorial Award, American Association for Cancer Research, 1999. Eli Lilly Award of the American Chemical Society, 1998.
DuPont-Merck Award of the Protein Society, 1997.
Schering-Plough Award of the American Society of Biochemistry and Molecular Biology, 1994.
Pew Scholar in the Biomedical Sciences, 1989-1993.
Harvard University, Boston, US
Debora is a mathematician and computational biologist with a track record of using novel algorithms and statistics to successfully address unsolved biological problems. She has a passion for interpreting genetic variation in a way that impacts biomedical applications. During her PhD, she quantified the potential pan-genomic scope of microRNA targeting and combinatorial regulation of protein expression and co-discovered the first microRNA in a virus. As a postdoc she and her colleagues cracked the classic, unsolved problem of ab initio 3D structure prediction of proteins using a maximum entropy probability model for evolutionary sequences. She has developed this approach to determine functional interactions, biomolecular structures, including the 3D structure of RNA and RNA-protein complexes and the conformational ensembles of apparently disordered proteins. Her new lab at Harvard is now developing the algorithms to use in the quantitating the effects of genetic variants, including those involved in antibiotic resistance.
Max Planck Institute, Martinsried, DE
Aarhus University, DK
MRC, Cambridge, UK
I am originally from Canada and studied Biochemistry at the University of British Columbia in Vancouver. In 1999, I moved to the UK for PhD studies with David Barford at The Institute of Cancer Research. Here I studied the Anaphase Promoting Complex/Cyclosome (APC/C) by reconstituting its activity in vitro and studying its structure by electron microscopy. After completing my PhD, I moved to Cambridge where I was a Career Development Fellow at the MRC Laboratory of Molecular Biology in Venki Ramakrishnan's lab, funded by a Beit Memorial Fellowship for Medical Research. In 2009, I started my own lab at MRC-LMB. I am also a fellow of Clare Hall. I was awarded an ERC Starting Grant in 2011 and was chosen to be an EMBO Young Investigator in 2015.
My work focuses on understanding the mechanisms of macromolecular protein complexes involved in regulating gene expression. I use an integrated approach combining structural, biochemical and functional studies. The lab aims to reconstitute multi-protein complexes and their activities, and determine their high-resolution structures to understand their mechanisms. Recent work has focused on the Cleavage and Polyadenylation Factor (CPF), the Pan2–Pan3 deadenylation complex and the Fanconi Anaemia core complex, an E3 ubiquitin ligase involved in DNA repair. My lab also recently developed new supports for electron cryo-microscopy (cryo-EM) that reduce radiation-induced specimen motion.
Purdue University, West Lafayette, US
I graduated from the University of London (B.Sc. (General), 1950; B.Sc. (Special), 1951; M.Sc., 1953) and the University of Glasgow (Ph.D., 1956), after which I was a postdoctoral fellow with Prof. William Lipscomb at the University of Minnesota at Minneapolis (1956-1958) and a Research Associate with Prof. Max Perutz at the MRC Laboratory of Molecular Biology, Cambridge, England (1958-1964). Currently I am the Hanley Distinguished Professor of Biological Sciences at Purdue University, where I have worked for the last 52 years. I am a member of the U.S. National Academy of Sciences, a foreign member of the British Royal Society, and a 2000-2006 member of the National Science Board, the oversight body for the National Science Foundation. I have received numerous international honors and have honorary degrees from universities in Canada, France, Sweden, England, and Belgium. My laboratory utilizes X-ray crystallography and electron microscopy to study the biological structure of various animal and bacterial viruses at atomic resolution to determine how these molecular assemblages recognize specific hosts, tissues, or cells; how they enter the cell and disassemble; and how newly synthesized viral components assemble and mature to form progeny viruses. I have studied single-stranded RNA rhino- (common cold), coxsackie-, polio-, and cardioviruses as well as the enveloped toga- and flaviviruses; single-stranded DNA human, canine, feline, and porcine parvoviruses and the bacterial φX174 virus; and the double-stranded DNA tailed φ29 and T4 bacteriophages.
The Rockefeller University, New York, US
I graduated from Cambridge University with a degree in Natural Sciences (Zoology), and then studied as a graduate student with John Kilmartin at the Laboratory for Molecular Biology in Cambridge, where for my Ph.D. project I developed techniques for the subfractionation of the yeast nucleus, isolating the yeast spindle organizer. We made a panel of monoclonal antibodies against these enriched fractions, eventually allowing the identification of yeast spindle pole and spindle-associated components and their subsequent functional characterization. We also showed that the complex structure of the yeast spindle organizer can be made simply from a few highly iterated proteins in successive crystalline layers. Then, as a postdoctoral researcher in Günter Blobel's laboratory at the Rockefeller University, I studied the NPC, which mediates trafficking between the cytoplasm and nucleoplasm, and also plays key roles in other crucial cellular processes. Using highly enriched yeast NPC fractions for a biochemical and structural approach, we generated the first inventories of its components. This work also demonstrated that there are distinct transport pathways, with many different but partially redundant and overlapping transport pathways all converging at the NPC.
In 1997 I started my own laboratory at the Rockefeller University, the main focus of which remains the NPC. Our studies have led to the first maps of the three-dimensional architecture of the NPC and the position of all its components, revealing the common evolutionary origins of this structure with vesicle coating proteins, and suggesting a model explaining the overall transport mechanism. We ultimately aim to generate dynamic maps of the transporting NPC at the atomic and microsecond level of resolution. We have also studied the kinetics of transport, revealing roles for binding and competition in the mechanism of the NPC, and how multiple and extremely rapid interactions between cargo-carrying transport factors and proteins in the NPC mediate both fast and specific nuclear trafficking.
Our NPC studies are examples of the potential of the our proteomic, structural and computational approaches, that have allowed us to dissect the structure and function of diverse macromolecular assemblies and interactome networks. Hence, in 2005, we formed the National Center for Dynamic Interactome Research (NCDIR; http://www.ncdir.org/). The central goal of the NCDIR is to address the urgent need for technologies that can rapidly, reliably, and routinely reveal and interpret the dynamic cellular interactome. These technologies are designed to enable the community to assemble detailed, dynamic representations of the interactions in the cell.
Merck, Kenilworth, US
I graduated Magna cum Laude in 1985 from Padova University (Italy) with a degree in Organic Chemistry. In 1989 I received my PhD in Organic Chemistry from the same university with a thesis in Structural Biology. In February 1990 I joined the laboratory of Dr. James C. Sacchettini at the Albert Einstein College of Medicine, Bronx (NY), as postdoctoral fellow, and subsequently as Instructor. My interest was initially for a class of small fatty acid binding proteins that had been related to obesity and diabetes. Subsequently most of my work was involved in bacterial enzymes that could be used as target for the design of novel antibiotics. During the 6 years I spent there, I mentored several graduated students and post-doctoral fellows.
In 1997 I joined Merck and Co., Inc, where I was involved in several projects, providing structural biology support for diabetes, inflammation and oncology targets. I developed and still maintain a particular interest in the structural aspects of Protein Kinases inhibition. My more recent work focused on the diabetes target DPP-4, and on how structural biology and modeling have helped the development of several potent inhibitors, and on the structure-function of antibodies. I published over 70 papers in peer-reviewed journals, and I have been invited to give several talks about my research at local universities and national and international meetings.
Heidelberg University, DE
I graduated in 1984 from the Ludwig-Maximilian University in Munich with the state exam in food chemistry. Despite this "exotic" start, I received my PhD in Biochemistry in 1989 from the same university for my thesis in biochemistry on the photosynthetic reaction center with H. Michel at the Max-Plank-Institute (MPI) in Martinsried. I followed him as a post-doctoral fellow to the MPI of Biophysics in Frankfurt, and in 1991 I joined Prof. Alwyn Jones at the Biomedical Center in Uppsala (Sweden) where I continued my training in protein crystallography working on various enzymes. In 1994 I became an independent group leader in the Structural Biology Programme at the EMBL in Heidelberg. During this time, I got interested in membrane protein biogenesis and protein targeting. Since 2000 I am full professor at Heidelberg University teaching biochemistry and structural biology, and I have supervised more than 50 graduate students and postdocs. Since I started my independent career, the signal recognition particle and related targeting systems became one of my main interests. More recent work also includes ribosome biogenesis and ribosome associated factors, which act early on the nascent chain and comprise targeting factors, enzymes and chaperones. A particular interest of my group are RNA-protein complexes and the combination of hybrid approaches in order to obtain mechanistic insights into the proteins, complexes and pathways of our interest.
NKI, Amsterdam, NL
University of Oxford, UK
After a first degree in biophysics at King's College London, I learnt protein crystallography at Bristol University during a PhD. I then moved to Oxford, and have been there mainly since, the largest interruption being a period spent working in China from 1981-83, at the Institute of Biophysics, Beijing. I am now an MRC research professor in the Division of Structural Biology, where my group has a major focus on structural virology, including structural analyses of viruses and virus-cell interactions to understand the fundamental biology of viruses and how this might be used to facilitate the development of new therapies, including antivirals and structure-based vaccines. Current work increasingly uses advanced cryo-electron microscopy to study both the viruses and their interaction with cells in molecular and atomic detail.
In addition to the fundamental biomedical research I have a longstanding interest in technology and infrastructure development. For example establishing the Oxford Protein Production Facility, and coordinating the pan European activities in biomedically-led structural proteomics (SPINE and SPINE-II Complexes). Currently I am director of Instruct, a pan European Infrastructure for Integrated Structural Biology. In addition I helped establish the UK National Centre for biological Electron Microscopy (eBIC), the first such user facility embedded at a synchrotron source. For some years I have also led life science developments at Diamond Light Source – a leading synchrotron for macromolecular structure determination.
NCI, Bethesda, US
Dr. Subramaniam received his Ph.D. in Physical Chemistry from Stanford University and completed postdoctoral training in the Departments of Chemistry and Biology at M.I.T. He is a currently a Senior Investigator at the NIH, and the founding Director of both the Center for Molecular Microscopy, and the National Cryo-EM Laboratory at the National Cancer Institute, NIH. He also holds visiting faculty appointments at the Johns Hopkins University School of Medicine and University of Maryland, College Park. His current work is focused on the development of advanced technologies for imaging macromolecular assemblies using 3D electron microscopy, and their application to address fundamental problems in HIV/AIDS, metabolism and cancer research.
ICR, London, UK
Dr Alessandro Vannini studied Biology at the University of Rome "Roma Tre" and undertook his Ph.D. research at IRBM "P. Angeletti" (Merck Research Lab), Rome, focussing on the structural characterisation of quorum-sensing proteins in pathogenic bacteria and of human histone-deacetylases (HDACs). For his post-doctoral research, supported by Marie-Curie and EMBO long-term fellowships, he joined Professor Patrick Cramer's laboratory in Munich, focussing on the architecture and regulation of yeast RNA polymerase III, the largest among the three eukaryotic RNA polymerases, by combining X-ray crystallography and cryo-electron microscopy. In 2012, Dr Alessandro Vannini joined the Institute of Cancer Research in London, UK, as Team Leader in the Division of Structural Biology. Using an Integrative Structural Biology approach, he and his team are focusing on the structural and functional characterisation of large macromolecular complexes that assemble at RNA polymerase III binding sites across the eukaryotic genome, in order to understand their role in tumorigenesis as well as in the 3D spatial organization of the genome. In 2016, Dr. Vannini was elected EMBO Young Investigator and Wellcome Trust Investigator.
A. van OIJEN
University of Wollongong, AU
After receiving his PhD in Physics from Leiden University (the Netherlands) in 2001, Antoine van Oijen was a postdoctoral fellow in the group of Sunney Xie at Harvard University's Chemistry department. In 2004, he started his own group at Harvard Medical School, followed by a move back to the Netherlands in 2010 as a full professor at Groningen University. In 2015, he moved to the University of Wollongong, Australia, as an Australian Research Council Laureate Fellow.
His research centers on the development and use of single-molecule biophysical tools to study complex biochemical systems. In particular, he is interested in understanding the mechanistic principles underlying the process of DNA replication. Using novel single-molecule fluorescence imaging and mechanical manipulation techniques, his work has allowed the direct visualization of the dynamics of individual replication complexes and has led to new insights into how genomic DNA is copied before cell division.
NIDDK, Bethesda, US
I have been a principal investigator in the Laboratory of Molecular Biology of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, since 1995. I was born in Shanghai, China and is a naturalized US citizen. I began her undergraduate studies of biochemistry at Fudan University in Shanghai before transferring to SUNY at Stony Brook to complete a B.A. degree. I received my Ph.D. in Biochemistry and Molecular Biophysics from Columbia University and held postdoctoral fellowships both at Columbia and Yale Universities. In 2011 I received the Dorothy Crowfoot Hodgkin Award from the Protein Society. I have been a elected member of the National Academy of Sciences (NAS) since 2013 and the American Academy of Arts and Sciences (AAAS) since 2015.
My current research centers on understanding the molecular mechanisms of DNA replication, repair and recombination with a focus on translesion DNA synthesis, genetic rearrangement and mismatch and nucleotide excision repair of damaged DNA. My group employs a multifaceted approach for analyzing the structures and activities of protein and nucleic acid molecules, including X-ray crystallography, electron microscopy, molecular biology, enzymology, and protein and nucleic acid chemistry. We have shown how different repair processes and directional motions are coupled to the energy supply of the cell, and how lesions in DNA can be avoided and bypassed by specialized synthetic enzymes. We have described how the substrate specificity of many enzymes is determined by a stringent requirement for a pair of metal ions held in a particular conformation. Recently our team has made use of crystallographic techniques to obtain the first atomic-resolution and time-resolved picture of DNA synthesis, discovering transiently associated metal ions that are essential for the addition of each new nucleotide unit.
Imperial College London, UK
Xiaodong Zhang graduated from Peking University in 1988, studying Nuclear Physics. She then continued her study in the United States and went to Stony Brook University to pursue her PhD in physics in the group of Professor Janos Kirz and David Sayre developing X-ray microscopy with chemical contrast. After she obtained her PhD in 1995, she decided to switch to biophysics/structural biology and went to Harvard University for her postdoctoral training under the guidance of Professor Don Wiley. She went to London, England in 1997 as a postdoctoral researcher at Imperial Cancer Research Fund (now part of Francis Crick Institute). She became a lecturer at Imperial College London in 2001, promoted to Reader in 2005 and became a Professor of Macromolecular Structure and Function in 2008. She is also a visiting professor of Peking University School of Life Sciences since 2007. Her current research focuses on using advanced structural biology and biophysical techniques such as x-ray crystallography and electron microscopy to study the macromolecular complexes inside our cells, especially those involved in gene regulation and DNA damage response. She aims to obtain movies of these complexes in action at the atomic level that will ultimately lead to a deeper understanding of the working these machines and novel therapeutic approaches for cancer and other human diseases.


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Tips for Serger Troubleshooting & a Quick Knit Headband Tutorial!
Happy National Serger Month! It may be the last day of April, but it's still a sergerific day! Sergers solve so many sewing problems; they finish seams nicely, can make a rolled hem in a flash and add a professional … Continue reading
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Clara Dress Sew-Along Week 2
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Free Stuff Friday with Christine Haynes & The Emery Dress Pattern!
Christine Haynes was in the studio today filming for Season 8 of Sew it All TV. Fans of Sew it All TV may remember Christine from way back to Season 2 episode 210 where she whipped up an adorable raincoat … Continue reading
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Learn How to Use a Serger to Insert a Zipper!
Have you ever thought about using a serger to apply a zipper? If not, you should! The traditional sewing machine and zipper foot method is always a good way to go, but using a serger can simplify the task and … Continue reading
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Clara Dress Sew-Along Week 1
Welcome to the Sew Liberated Clara Dress sew along! The dress is a lovely shirtwaist style dress with a keyhole sleeve detail. The skirt is comfortable and easy to wear, as it has an elastic waist and side seam pockets. … Continue reading
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Free Stuff Friday – Enter to win a prize!
Today's Free Stuff Friday is a wonderful book on Nickel Quilts by Pat Speth and Charlene Thode. Leave a comment in the box below on what is your biggest sewing pet peeve and why. Winners will be announced next week! … Continue reading
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Enter to Win Fabric from Westminster Fabrics for the Clara Dress Sew-Along!
Get ready for spring with the Clara Dress Sew-Along! This dress is so sweet and lovely for spring and summer. The Clara dress is from Sew Liberated, indie pattern maker of all sorts of wonderful garment patterns. Head to Sew … Continue reading
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Wong Tsu
Wong Tsu (1893–1965; Chinese: 王助) was a Chinese aeronautical engineer.
Life and education[edit]
Tsu was born in Beijing, China. At the age of 12, he was selected as a naval cadet, and at 16 he was sent to England to study naval engineering, then to the U.S. to study aeronautical engineering at the Massachusetts Institute of Technology.
In the U.S. his name is sometimes inverted to Tsu Wong, to put the family name last, as is the western custom.
Graduating in 1916 from MIT, he learned to fly at the Curtiss Flying Boat School in Buffalo, New York. He was then hired by the fledgling Boeing Aircraft Company in May, 1916.[1] and assisted in the design of its first successful product, the Boeing Model C,[2][3] more than 50 of which were acquired by the U.S. Navy.[2] He also brought considerable expertise in wind tunnel testing to Boeing, and advised on the design of the Boeing Aerodynamical Chamber at the University of Washington. In 1917, after around a year at Boeing, he returned to China where he became chief secretary of the airline China National Aviation Corporation. His picture appears in the account of Central Aircraft Manufacturing Company, a joint venture between China and the Curtiss-Wright Corporation.
When the Kuomintang government was defeated in the civil war, Wong went to Taiwan where he became professor of aviation at Cheng Kung University.
During his lifetime, Wong is believed to have had a hand in designing 30 aircraft. In 2004, at a time when it was hoping to increase its ties to the Chinese aviation industry, Boeing unveiled a plaque and exhibit at its Museum of Flight in Seattle, Washington, honoring his work as its first engineer.[4]
- ^ Areddy, James (24 September 2015). "The Chinese Birdman Who Got U.S. Aircraft Giant Boeing Flying". WSJ Blogs - China Real Time Report. Retrieved 2016-01-22.
- ^ a b Bauer, Eugene (2000). Boeing: the first century. TABA Publishing. p. 18. ISBN 1879242095.
- ^ Fallows, James (2013). China Airborne: The Test of China's Future. Knopf Doubleday. p. 50. ISBN 9781400031276.
- ^ Vu, Carol. "An aviation pioneer, no longer forgotten". www.nwasianweekly.com. Retrieved 2016-01-22.
External links[edit]
- Eve Dumovich, "The 1st and the Best"


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Brain & Nervous System Health Center
Spinal Cord Injury: Your Rehabilitation Team - Topic Overview
When you are recovering from a spinal cord injury (SCI), it is best to work with a group of health professionals known as a rehabilitation (rehab) team. Your rehab team designs a unique plan for your recovery that will help you recover as much function as possible, prevent complications, and help you live as independently as possible.
- You and your family are the most important people on the team. The other team members are there to answer your questions and help you.
- A rehabilitation doctor is in charge of your medical care. This is often a physiatrist (a doctor who specializes in physical medicine and rehab). Some physiatrists take additional training in spinal cord injuries to become spinal cord injury specialists.
- A rehabilitation nurse specializes in nursing care for people with disabilities. This nurse provides nursing care, educates you and your family about the medical side of an SCI, and helps the doctor coordinate medical care. He or she will help you but will also expect you to do as much as possible yourself.
- A physical therapist evaluates and treats problems with movement, balance, and coordination. He or she provides training and exercises to improve mobility, such as using a wheelchair or moving from a wheelchair to other locations. The physical therapist also teaches family members how to help with your exercise, if needed.
- An occupational therapist helps you with daily tasks, such as eating, bathing, dressing, writing, or cooking. You may have to learn new ways to do these things. He or she will also help you increase the strength of your upper body and arms.
- A speech-language therapist helps you relearn how to chew and swallow food and relearn language skills and learn other ways to communicate if your spinal cord injury has affected the muscles that control your mouth, throat, and neck. This is not always necessary.
- A social worker helps you make decisions about rehabilitation and helps you plan your return to home or a new living place. He or she helps you with questions about insurance and other financial issues and can arrange for a variety of support services. Social workers also provide or arrange for counseling to help you deal with any emotional problems.
- A recreation specialist helps you return to activities that you enjoyed before the SCI. He or she will help you use the skills you are learning in other areas (such as physical or occupational therapy) in your hobbies. Your recreation specialist will help you return to community life by taking you shopping or to the movies, for example.
- A licensed counselor helps you and your family deal with the emotional effects of your SCI. Counselors use interviews and tests to identify and understand emotional problems. They may treat thinking or memory problems or provide advice to other professionals about your mental state.
Other professionals that may help you during your rehab include a registered dietitian to help you prepare a balanced diet and take care of any special dietary needs, a vocational counselor to help you find a job, and a sexual health specialist to help with intimacy and fertility issues.
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WebMD Medical Reference from Healthwise


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Full name Martin Paterson Donnelly
Born October 17, 1917, Ngaruawahia, Waikato
Died October 22, 1999, Sydney, New South Wales, Australia (aged 82 years 5 days)
Major teams New Zealand, Canterbury, Middlesex, Oxford University, Warwickshire, Wellington
Batting style Left-hand bat
Bowling style Slow left-arm orthodox
|Test debut
|England v New Zealand at Lord's, Jun 26-29, 1937 scorecard
|Last Test
|England v New Zealand at The Oval, Aug 13-16, 1949 scorecard
|Test statistics
|First-class span
|1936/37 - 1960/61
Wisden obituary
Martin Paterson Donnelly, who died on October 22, 1999, aged 82, left an indelible impression on cricket despite the brevity of his career. As a New Zealander at Oxford, he entranced cricket-followers in the immediate post-war years in a manner surpassed only by Compton. He proved that reality matched appearance with a magnificent double-century against England in the Lord's Test of 1949. C. B. Fry said he was as good a left-hander as any he had seen, including Clem Hill and Frank Woolley. Then Donnelly retired and became a businessman in Sydney.
For New Zealanders, his career was even more tantalising, since he played only 13 of his 131 first-class games in the country. None the less, he did enough in his seven Tests to raise the country's cricketing profile, and establish himself among the country's best-remembered sporting heroes. when he was elevated to the New Zealand Sports Hall of Fame in 1990, the citation read: They said he had everything as a Test batsman: style and grace; confidence and determination; success and modesty. The words they said encapsulate the sense of loss that surrounded Donnelly, despite his long life. His cricket was a victim of the war, the lowly cricketing status of his country at the time, and the game's financial circumstances.
Donnelly was born in 1917 to a country family in Waikato, one of twin brothers; his twin died in the flu epidemic the following year. Martin's sporting talent emerged quickly, though he was never tall - not much bigger than a lemonade bottle, said one contemporary - and was known to his team-mates as Squib. In 1933, he got a letter from Bradman, organised by his Uncle Vic, looking forward to the young man taking his place amongst his country's champions. It happened very rapidly.
After just one first-class match for Wellington, in which he scored 22 and 38, Donnelly was selected, aged 19, for the 1937 tour of England. The selectors were impressed by his style and, above all, by his outfielding. They kept faith and picked him for the First Test at Lord's even though he came into the match with two successive ducks. He got a duck again, but that was no worse than Len Hutton, who was also making his debut. In the second innings, he came in at No. 9 and helped save the game in idiosyncratic fashion, which included a certain amount of hooking. As the series developed, his qualities shone through: he stood alone as New Zealand collapsed to defeat at Old Trafford, and scored fifty in barely an hour at The Oval. He had already scored 144 there against Surrey. Wisden praised his batting style and his coolness.
Though he played some cricket at home over the next few seasons, there were no major opportunities. Donnelly volunteered for military service, and in 1942 embarked for Egypt, where he was a tank commander, and star of the show at the Gezira Sporting Club. In some Cairo bazaar he picked up the multicoloured cap that he used as a lucky mascot. The war took him to Italy, and - evidently with a little help from the sympathetic New Zealand commander, General Freyburg - to England in time for the moment when the public was ready for cricket again. He scored magnificent hundreds in exhibition matches at Edgbaston and Scarborough in 1945, but topped them both in the match Denzil Batchelor called the perfect game, when the Dominions beat England at Lord's with eight minutes to spare. Donnelly hit 133 in three hours. You sat and rejoiced, wrote Batchelor, hugging your memories to your heart and gradually letting the dazzle fade out of your eyes.
That autumn, Donnelly went up to Oxford to read history, and became a Dark Blue institution. His graceful batting was regarded by a generation of undergraduates as the best free show in town; as soon as the word went round that he was in, they would flock to watch. In 1946, he scored six centuries, including 142 against Cambridge. As captain 1947, he averaged 67; though he missed his century in the University Match, he scored 162 for the Gentlemen, which included 50 in 40 minutes. It was the climax to a delightful display, said Wisden, his punishment of any ball not a perfect length being severe and certain; he excelled with off-drives; hooked or cut anything short. This ensured his selection as a Cricketer of the Year, the article casually describing him as the world's best left-hander. By then, he had played fly-half for an all-conquering Oxford rugby team and, less successfully, centre for England at Lansdowne Road on a bitterly cold day when Ireland scored what was then their biggest win over them.
But Donnelly's thoughts were already turning to the future. He got a job with Courtaulds, who were sympathetic enough to let him play half the matches for Warwickshire in 1948- without his customary success - and to join the 1949 New Zealand tour. Together with another left-hander, Bert Sutcliffe, he taught the English public and cricket establishment to understand that here was a country of growing sporting significance, which should never again be palmed off with three-day Tests. All four games were drawn and Donnelly failed only in the last. He made 64 at Headingley, and 75 and 80 at Old Trafford. Sandwiched in between was his epic at Lord's, when he scored what remains the only double-century for New Zealand against England: 206 in just under six hours. But his career was almost over. In 1950, he married; that year he played just four matches for Warwickshire, captaining them against Yorkshire when he scored his only century in county cricket: Wisden almost drooled: glorious... artistic...perfect timing. Then it was over. He sailed for Sydney in the autumn to become the sales and marketing manager of Courtaulds Australia. His cricket thereafter was minimal. Though he played in a first-class match as late as 1961, for the New Zealand Governor-General's XI against MCC, he spent far more time fly-fishing. He had certain similarities with Bradman, wrote Alan Gibson in 1964, the build, the hawk-eye, the forcing stroke square of the wicket on the leg side, the determination to establish a psychological supremacy over the bowler as soon as possible. But Donnelly did not share Bradman's passion never to get out. As with his batting, so with his career. As Frank Keating put it: It was as if all his own cricket had been a student pastime, a youthful wheeze not worth mentioning any more.
Wisden Cricketers' Almanack
Wisden Cricketer of the Year 1948
Loose West Indies succumb to Ashwin's wiles
One after another, the hosts' batsmen attempted questionable flicks and drives in their second innings, disregarding the drift and dip the offspinner was generating
Ashwin emulates Botham with ton and seven-for
Stats highlights from the fourth day's play in Antigua where Ashwin's maiden five-wicket haul outside Asia bowled India to an innings victory
Stats highlights from the first day of the Antigua Test, where Virat Kohli and Shikhar Dhawan stole the show from the hosts
Remembering West Indies' last major series win
Against India in 2002, Hooper, Dillon, Chanderpaul and Co. gave their fans something to cheer about
Manjrekar: 'Kohli reminds me of Tendulkar'
Former India batsman Sanjay Manjrekar analyses the various aspects of the first day's play in Antigua
The case for four-day Tests (69)
Shorter matches spell good news for spectators and broadcasters. Cricket has a little to lose and a whole lot to gain by truncating its premier format
Standout performers continue to carry England (68)
A crushing victory over Pakistan gave England plenty to be pleased about but familiar concerns remain over the make-up of the side
Loose West Indies succumb to Ashwin's wiles (54)
One after another, the hosts' batsmen attempted questionable flicks and drives in their second innings, disregarding the drift and dip the offspinner was generating
Herath versus the mighty Australians? (45)
Sri Lanka's lead spinner must feel like a bus driver in charge of a spluttering vehicle as the hosts strive to challenge a strong Australian side
Cook braves criticism as England play it safe (39)
There was enough logic in Alastair Cook's decision not to enforce the follow-on to make it understandable at worst and reasonable at best


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Tour Dates
In 2015, we released three EPs and toured a bunch. See? Now we're spending some time putting the finishing touches on our full-length, which we'll put out in the fall. We'll get stir crazy and play shows soon enough. Make sure to sign up for the totally brilliant and witty monthly newsletter on our home page so we can let you know when we're coming to you.


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Mo. K9 dies after being shot in head during burglary
By Debby Woodin
The Joplin Globe
JOPLIN, Mo. — A police dog shot in the head early Tuesday by a robbery suspect ultimately died, a Joplin police officer said.
Officer Travis Walthall, supervisor of the Joplin Police Department's K-9 unit, said by telephone Tuesday afternoon that the dog, Cezar, was expected to survive the gunshot wound unless complications arise.
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Vegetable Two-Grain Casserole
Total Time
Prep 15 mins
Cook 1 hr 15 mins
From BHG.
Ingredients Nutrition
- 1 (18 7/8 ounce) canready-to-serve lentil soup (vegetarian)
- 1 (15 ounce) can black beans, rinsed and drained
- 1 cup small fresh mushrooms, quartered
- 1 cup sliced carrot
- 1 cup frozen whole kernel corn
- 1⁄2 cup pearl barley
- 1⁄3 cup bulgur
- 1⁄4 cup chopped onion
- 1⁄2 teaspoon black pepper (or to taste)
- 1⁄4 teaspoon salt (or to taste)
- 1⁄2 cup water
- 1⁄2 cup shredded cheddar cheese
- In a mixing bowl, combine the first 10 ingredients; stir in the water.
- Transfer mixture to an ungreased 2-quart casserole.
- Bake, covered, at 350° for 1 hour, 15 minutes or until the barley and bulgur are tender, stirring twice.
- Stir again; sprinkle with cheese.
- Cover and let stand about 5 minutes or until cheese is melted.
Most Helpful
I liked this recipe very much...it was healthy, easy comfort food. The next time I make it, I may sautee the mushrooms before adding to the casserole (for some reason, they still seemed a bit raw-ish). Apart from that, I wouldn't change anything. I bet it would work well with grain substitutions, though (maybe quinoa?). Thanks for sharing...this recipe was enjoyable, and helped me clean out some things that had been languishing in my pantry, too.
Loved this. I didn't expect much from this since the ingredients really aren't too exciting, but it was so good. I do not use bulgur so I substituted some brown rice. I also added some hot sauce. I disagree with the first poster on one thing - I don't think the leftovers heat well at all. But maybe that is because of the rice I used? Great comfort food. Thank you!
Yumm. This turned out really good. It is so easy to make and is great for a work night meal. Didn't add any exra salt as there is plenty in the canned items. Did add a dash of garlic powder. Leftovers were tasty the next day for lunch. Will make again for sure. Thanks!


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BEIS estimates 88MW installed in Q2 2016
The Department of Business, Energy and Industrial Strategy has estimated that just 88MW of solar was installed in Q2 2016, less than half than was deployed in Q2 2015.
The Department of Business, Energy and Industrial Strategy has estimated that just 88MW of solar was installed in Q2 2016, less than half than was deployed in Q2 2015.
Solar Power Portal runs through this week's people news from within UK solar, including news from the PwC employment survey and opportunities at the STA and Quintas.
Bristol Sport is set to benefit from significant savings on its energy bills after completing a deal with Bristol City Council to purchase energy generated from new solar panels installed on the West stand of the Ashton Gate Stadium.
Sadiq Khan's efforts to be "the greenest mayor London has ever had" have been bolstered by City Hall's announcement that it has applied for a licence to supply low carbon electricity, despite no news yet of increased renewable energy generation within the city.
DuPont, an industry leader in high-performance materials for photovoltaic panels, shares best practices for solar array design, component selection and long-term maintenance.
The UK government needs to provide "continuity and stability" in its energy and climate change policy according to the Confederation of British Industry (CBI), which has called on Greg Clark to pick up the baton left by former energy secretary Amber Rudd.
NextEnergy Solar Fund has added a further £42 million to its acquisition firepower after closing a tap share issue programme.
The UK government should make clear its views on a subsidy-free market stabilisation model for technologies left out of the Contracts for Difference scheme, according to the latest select committee report to criticise the government's handling of the renewables industry.
Employment in the UK's domestic solar industry has contracted by approximately one-third in the last year against a backdrop of subsidy cuts and other policy interventions, and further job losses are strongly expected.
The Trade Union Congress (TUC) has claimed that the green economy could offer vital support for a post-Brexit Britain and create thousands of additional jobs.
Solar Power Portal runs through this week's people news from within UK solar including changes at the top of Anesco and Absolute Solar and Wind, as well as the likely new ministerial appointments to the energy brief at the Department of Business, Energy and Industrial Strategy.
Tesla's claim of having "The World's Fastest Charging Station" has been upheld by the UK's advertising watchdog following a challenge by Ecotricity, which argued its claims could not be substantiated.
Insurance giant Chubb is to bolster its UK-facing clean tech portfolio by launching a new product aimed at owners of solar plants.
Lark Energy has secured a UK patent for a new renewable solar thermal technology to create steam for industrial processes.
The newly formed Department for Business, Energy and Industrial Strategy (BEIS) could see energy policy relegated to a 'steady as she goes' approach while other policy areas take precedence, according to a government MP in the energy and climate change (ECC) select committee.


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- I'm done, close this
Enter Our Ultimate Summer Tech Giveaway!
That's right - we are giving away a Summer Tech Package that includes a high-tech Fuego Element grill, Monster Superstar Backfloat waterproof speaker, and a mobile charging bank from iFrogz! Head on over to our giveaway page in order to enter. Good luck!
Thursday May 28, 2009 3:18 pm
Kindle Encourages Bloggers to Join Subscription Service
Posted by Sheila Franklin Categories: Internet, Misc. Tech
Amazon has unveiled its new beta program that will pay bloggers for turning them into Kindle subscriptions. Although it already offers many of them, the company wants to move the content to the home screen. Subscriptions will run from $.99 to $2.00 per month. Bloggers don't pay any fees, but Amazon sets the price as well as keeping 70% of the price. Still, if you want new readers and pocket change, this might be an option for your blog.
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- amazon, beta program, blogs, kindle, payment, percentage, subscription
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Black Forest Protein Shake
Total Time
Prep 1 min
Cook 0 mins
You could probably make this with chocolate flavored protein powder instead of using vanilla powder and cocoa. I drink this for breakfast.
Ingredients Nutrition
- 1 cup skim milk
- 1 scoop vanilla protein powder (I use GNC Pro Performance Soy Protein 95)
- 1⁄2 teaspoon unsweetened cocoa powder
- 1⁄2 cup pitted frozen cherries
- Add everything to the blender and mix well.
- Nutritional info for protein powder:.
- One Scoop (33 g): Calories 130, Calories from fat 15, Total Fat 1.5g, Saturated Fat 0g, Cholesterol 0g, Soduim 290g, Total carbs 3 g, Fiber 0g, Sugars 2g, Protein 25g.
Most Helpful
This is really good, definitely better using chocolate protein powder and 1 tsp cocoa but I'm a big chocolate fan.


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had another apt and scan today. Did the glucose test. No news is good news...I guess if tomorrow goes by and I dont hear from them then everything was fine (which is what the doctor is suspecting). I have gained a total of 20 pounds as of now. My blood pressure was 100/50. The ultrasound was good. Cervix is nice and long, fluid is normal, major organs are looking normal...she is still a she...and her heart rate was 124 (LOW). She is head down....and measuring in the 75%!! BIG GIRL!! So...a wonderful appointment! we estimate 10or 11 more weeks until we meet her!! I have only gone past 38 weeks twice out of 8 kids before!! getting soooo excited!
doc apt.
So exciting! Glad she looks well in there....wow.....11 weeks. That is so soon!
I've never gone less than 40 weeks--lol. So I'm planning on a due date baby (or later!)
Do you have a name for your sweet girl? We are still stumped on names.
Sounds like a great appointment!
I would LOVE to see this little boy again on u/s - I'm having a hard time thinking it's actually a boy, weird huh?
Yay for a great appointment! I can't believe it's only 10 or 11 more weeks?! Yikes!!!
I have a repeat u/s in a week and a half to double check my cervical length again, and I'm excited to see him again!! It's amazing how much they grow into "little people" at this point! I have a hunch he is head down, based on movements, so I am curious to see!
Again, so glad everything looks great!!
Awesome for you! So exciting! Not to make you nervous. I didn't hear anything from my Glucose test until the doc appt today (two weeks later) and found out that there is a high possibility of me having it). I want nothing but the best for you! And your bp looks great! I am due to deliver in 9-10 weeks per doctor...I can't believe this is going to happen again!!!
Glad you had a good appointment!