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- Admissions
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The roles of international organizations, networks, and actors often influence the development of policies and outcomes on a range of global issues. From multilateral investments in developing economies to the emergence of international legal standards and systems, global governance research often serves as a theoretical foundation for how the academic, policy, and practitioner communities see the world. Global governance at SIS seeks to enhance our understanding of global history, political dynamics, and economic systems that shape the contemporary functioning of the international system and its organizations. Examples of research include an assessment of the conditions that lead to civic engagement and reconstruction in fragile settings, the exploration of social, political, and ecological dimensions that underlie urban water governance, and the examination of how the urban poor make decisions about their lives that lead to sweeping political and governance reforms. Scholarship in this issue area broadly covers the following topics:
International Relations
International Communication & Public Diplomacy
International Organizations
Intercultural Relations
For additional information related to scholarly research pursuits in global governance, click here.
Southeast Asia
Multilateralism and global governance
Human security
International relations theory
The End of American World Order (Polity, Cambridge UK , 2014)
The Making of Southeast Asia: International Relations of a Region (Ithaca: Cornell University Press, 2012, and Singapore: Institute of Southeast Asian Studies, 2012).
"Dialogue and Discovery: In Search of International Relations Theories Beyond the West," Millennium, vol. 39, no.3 (2011), pp. 619-637.
Whose Ideas Matter? Agency and Power in Asian Regionalism (Ithaca: Cornell University Press, 2009).
International law
International organizations
United Nations
International Criminal Court
Rough Justice The International Criminal Court in a World of Power Politics (Oxford University Press, 2014)
Bosco, David, "Course Corrections: The Obama Administration at the United Nations" (May 30, 2011). The Hague Journal of Diplomacy, Vol. 6, pp. 335-349, 2011.
Bosco, David, "The International Criminal Court and Crime Prevention: Byproduct or Conscious Goal?" Michigan State Journal of International Law, 19: 163-200, 2010.
Five to Rule Them All (Oxford University Press, 2009)
Global tourism
International migration
Gender and development in Southeast Asia
Intercultural communication
International education
Cosmopolitan Sex Workers: Women and Migration in a Global City. Oxford University Press, 2013.
Cruising in the Global Economy: Profits, Pleasure and Work at Sea. Ashgate Press, 2008.
"Diversification and Privatization": Securing Insecurities in the Receiving Country of Malaysia in Asia Pacific Journal of Anthropology 9, 4 (2008): 285-303.
International communication
Global information and communication technology
Transnational NGOs and global civil society
Virtual organizations and teams
Geographically distributed collaborative learning
N. Zakaria, D.L. Cogburn (2010) "Context-Dependent vs. Content-Dependent: An Exploration of the Cultural Behavioural Patterns of Online Intercultural Communication Using E-Mail." . In International Journal of Business and Systems Research 4 (3).
Derrick.L Cogburn (2010) Computer-Mediated Communication Technologies and Cross-National Learning. In The International Studies Encyclopedia.
"Globalization, Education and Learning in the Information Economy," Derek C. Mulenga (ed.) Globalization and Lifelong Education: Critical Perspective, Lawrence Erlbaum Associates, 2008.
Identity politics
Ethnic relations
Governance and economic development in Indonesia, Malaysia and Singapore
Nexus between Islam and gender relations in Southeast Asia
Increasing salience of non-traditional/human security issues
"A Constructivist Perspective of the Regional Order in Southeast Asia: Norms Transformation in ASEAN and the ASEAN Charter," Tamkang Journal of International Affairs, October 2009.
"Globalization with Chinese Characteristics: Building China-ASEAN Regional Cooperation," Globalization and East Asia, Tamkang University (Taiwan), 2007.
"The Mahathir Generation and Nation Building in Malaysia," Reflections: The Mahathir Years, John Hopkins University Press, 2004.
International organizations
Global environmental politics
International Organizations in World Politics, CQ Press, forthcoming.
"The Politics of IO Performance,"special issue of Review of International Organizations 5:3. Co-edited with Alexander Thompson.
"When Doing Good Does Not: The IMF and the Millennium Development Goals," in Who Governs the Globe? edited by Deborah D. Avant, Martha Finnemore, and Susan K. Sell (Cambridge 2010).
Banking on the Environment: Multilateral Development Banks and Their Environmental Performance in Central and Eastern Europe. MIT Press, 2002.
Culture and agency
International relations theory
Philosophy of science
Sociological methodology
The role of rhetoric in public life
Political and social theory of Max Weber
"Rationalizing Realpolitik: The Liberalizing of Historical Pessimism in American International Relations," chapter for Neil Gross, ed., Professors and their Politics (Johns Hopkins Press, 2014).
The Conduct of Inquiry in International Relations: Philosophy of Science and its Implications for the Study of World Politics (Routledge, 2011). Recipient of the International Studies Association-Northeast's Yale H. Ferguson Book Award, November 2012.
"How to Think About Civilizations," in Civilizations in World Politics: Plural and Pluralist Perspectives, Routledge 2010.
International relations
International political economy
Global governance
Asian regional institutions
Evolution of the nation-state
Political economy of international finance
Politics in the New Hard Times: The Great Recession in Comparative Perspective (co-editor with David A. Lake). Cornell University Press, 2013.
Integrating Regions: Asia in Comparative Context (co-editor with Andrew MacIntyre). Stanford University Press, 2013.
"Rising Powers and Global Governance: Negotiating Change in a Resilient Status Quo," International Affairs, 89, 3 (May 2013), pp. 711-729.
East Asian security
Korean politics and foreign policy
The diplomatic history of East Asia
International relations theory
The Making of Hegemony: China-Japan-Korea Relations in Early Modern East Asia, Complete book manuscript under review
"Diplomatic Ritual as a Power Resource: the Politics of Asymmetry in Early Modern Chinese-Korean Relations," Journal of East Asian Studies, vol. 13, no. 2 (May-Aug. 2013), pp. 309-36.
"Politics of South Korea," in Richard Valelly, ed., Oxford Bibliographies Online: Political Science (New York: Oxford University Press, 2013); with Victor Cha.
"Politics of North Korea," in Richard Valelly, ed., Oxford Bibliographies Online: Political Science (New York: Oxford University Press, 2013); with Victor Cha.
Internet policies and governance
Cross-national alliances
International science and technology policy and administration
Change processes
Culture, communication and social entrepreneurship
"Innovation in Cross-National Alliance Ecosystems." International Journal of Entrepreneurship and Innovation Management 11 (2010): 258-263.
"Teaching Globalization, Globally: A Seven-Year Case Study of South Africa-US Virtual Teams," (with D. Cogburn), Information Technologies and International Development, Vol. 4, Issue 3, Spring 2008.
"Help Me, Help You: A Triple-Track Approach to Maximizing Collaborative Learning in Complex, Cross-National Virtual Teams," (with D. Cogburn), Computer Supported-Collaborative Learning: Best Practices and Principles For Instructors, ed. by A.L.R. Lassiter and K. Orvis, Information Science Publishing, 2007.
Intercultural communication
Intercultural education and training
Maximizing study/work abroad
Global leadership development
Cross-cultural negotiation
The role of culture in language learning
Nam, K. A. & Condon, J. (2010). "The D.I.E. is cast: The Continuing Evolution of Intercultural Communication's Favorite Classroom Exercise." International Journal of Intercultural Relations, 34 (1), 81-87.
Nam, K. A. & Fry, G. (2010). "The development of Global Literacy and Intercultural Competence as a Response to the Complex Challenges of the 21st Century: A Meta-synthesis." The Asian Journal of Educational Research and Synergy, 2 (2), 9-32.
Fry, G., Paige, R. M., Jon, J., Dillow, J., & Nam, K. A (2009, November). "The Transformative Power of Study Abroad." Portland, Maine: Council on International Educational Exchange (CIEE).
Political economy of globalization
Human and global security
North/south relations
Global politics of race, culture and identity
Counter-Hegemony and Foreign Policy: The Dialectics of Marginalized and Global Forces in Jamaica, State University of New York Press, 2001.
Race and International Relations - A Special Issue of Alternatives, co-editor (with R.B.J. Walker), 2001.
National security
International political economy
International migration
Ethnic conflict
International law
National Security and Immigration: Policy Development in the United States and Western Europe Since 1945. Stanford University Press, 2006.
The UN system
Theories of international relations
International cooperation
International organization
Political leadership
Michael Bluman Schroeder (2014). "Executive Leadership in the Study of International Organization: A Framework for Analysis." International Studies Review 16(3): 339-361.
Michael Bluman Schroeder (2014). "NGO Transnational Advocacy for Accountability: From Declarations of Anti-Impunity to Implementing the Rome Statute." (with Alana Tiemessen.) in Implementation and World Politics: How International Norms Change Practice. Alexander Betts and Phil Orchard (eds.) New York: Oxford University Press.
Michael Bluman Schroeder (2013). "The Politics of Change at the United Nations: The Evolution of Electoral Services, 1989-2006." Global Governance 19(2): 207-226.
International education
Cross-cultural communication
Community organizing for school reform
Critical race theory
Education policy implementation
Intercultural leadership
Qualitative research methods
Taylor, A., Kuttner, P., Westmoreland, H. (2011). Cement Between the Bricks: Building New Schools in New York City. In M. Warren and K. Mapp (eds.) A Match on Dry Grass: Community Organizing as a Catalyst for School Reform. Oxford University Press.
Frankenberg, E., Merseth, K. & Taylor, A. (May 2010). Walking the Walk: Teacher candidates' professed commitment to urban teaching and their subsequent career decisions. Urban Education, 45(3): 312-346.
Taylor, A., & Frankenberg, E. (July 2009). Exploring urban commitment of graduates from an urban-focused teacher education program. Equity & Excellence in Education, 42(3): 327-346.
State capacity
Judicial politics
Latin American political economy
Praça, S. and Taylor, M. M. (2014), Inching Toward Accountability: The Evolution of Brazil's Anticorruption Institutions, 1985–2010. Latin American Politics and Society, 56: 27–48.
Matthew M. Taylor (2014). The Limits of Judicial Independence: A Model with Illustration from Venezuela under Chávez . Journal of Latin American Studies, 46, pp 229-259.
Matthew M. Taylor (2013), The Open Question Behind Brazil's Rise on the World Stage, International Affairs Forum, 4(1): 55-58.
Judging Policy: Courts and Policy Reform in Democratic Brazil. Stanford University Press, 2008. Recipient of the Victor Nunes Leal Prize, for best book in political science and international relations, Brazilian Political Science Association
Cross-cultural and international communication, adaptation, negotiation, and conflict
American culture, managing cultural diversity, race relations
Human behavior, counseling
Hostage negotiations
Intercultural Relations: Communication, Identy and Conflict. Pearson Learning Solutions, 2013
Editor, "Intercultural Relations," The Journal of International Communication, 2004.
Culture, Communication and Conflict: Readings in Intercultural Relations, 3rd ed. Pearson Learning Solutions, 2000.


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In the development of this work, planned primarily for the medical student and general practitioner, the authors have followed classic arrangement by beginning with the general diagnostic procedures, including a chapter on history taking and physical examination, and then considering the organs of the urogenital tract in anatomic sequence from without inward. The first volume covers the external genitalia, with a special chapter on gonorrhea, and includes all the tissues through the prostate gland. The second volume is concerned with the bladder, the ureters and the kidneys, and there is a concluding chapter on radium and roentgen therapy of the genito-urinary tract.
Exceptional in this book are the magnificent illustrations by Didusch, of which there are a tremendous number both in black and white and in colors. Exceptional also is the readability of the type, which makes study of the book a veritable pleasure for the eye. The work is
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ENGAGEMENT: Downs-Kirkpatrick
Published: Sunday, June 3, 2012 at 3:30 a.m.
Last Modified: Saturday, June 2, 2012 at 12:06 a.m.
Mr. and Mrs. Roger Downs of Northport announce the engagement of their daughter, Carla Tallent Downs to Eric James Kirkpatrick, son of Mr. and Mrs. James Kirkpatrick of Northport.
The wedding will be at 6:30 p.m. on July 14 on Oak Island at Lay Lake in Wilsonville.
The bride-elect is the granddaughter of Lucille Botta and the late George Botta of Ormond Beach, Fla., and Doris Downs and the late Carl Downs of Toney.
She is a 2005 graduate of Tuscaloosa County High School and attended the University of Alabama, where she received a bachelor's degree in Psychology in 2009 and a master's degree in School Psychology in 2012. She will be a School Psychologist intern at the Santa Rosa County School District in Pace, Fla.
The prospective groom is the grandson of the late Mr. and Mrs. Raymond C. Kirkpatrick of Mobile and the late Mr. and Mrs. Woodie Essary of Reform.
He is a 2005 graduate of Tuscaloosa County High School and attended the University of Alabama, where he received a bachelor's degree in education in 2009. He is employed by Buffalo Rock in Pensacola, Fla.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Austin, TXUSA
August 14, 2012
Todd Frenzel is the Director of Data Center Operations for Experian Healthcare, formally MPV. We use Confluence, JIRA and simba and are actively upgrading all three.
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Books will not be issued or checked out from the Media Center to students who currently owe for lost or damaged books. All debt must be cleared prior to issuing or checking out books for the school year.
Saturday, July 23, 2016
Ms. Joanna Myles
Math Department Team Leader
Uniform Policy


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About Me
Conditions and Treatments
Show More Conditions
- Assistant Professor, Department of Surgery
Board Certifications
- American Board of Surgery - Surgery, 2009
Education and Training
- Fellowship, Norton Health Care, Advanced Laproscopic Surgery, 2010
- Residency, NYU School of Medicine, Surgery, 2009
- MD from Tulane University, 2000
Locations and Appointments
- Aetna HMO
- Aetna Indemnity
- Aetna Medicare
- Aetna POS
- Aetna PPO/EPO
- Affinity
- Affinity Exchange- Essential
- Alphacare
- Cigna EPO/POS
- Cigna PPO
- Empire Blue Cross Blue Shield EPO
- Empire Blue Cross Blue Shield HMO
- Empire Blue Cross Blue Shield Indemnity
- Empire Blue Cross Blue Shield MediBlue
- Empire Blue Cross Blue Shield POS
- Empire Blue Cross Blue Shield PPO
- Empire Blue Cross Blue Shield Pathways, Enhanced
- Fidelis Child Health
- Fidelis Essential
- Fidelis Exchange
- Fidelis Family Health
- Fidelis Medicaid
- Fidelis Medicare
- HIP Access I
- HIP Access II
- HIP Child Health
- HIP Essential
- HIP Family Health
- HIP Medicaid
- HIP Medicare
- HealthSmart (WTC)
- Healthfirst
- Healthfirst Essential
- Humana Medicare
- Local 1199 PPO
- MagnaCare PPO
- Medicare
- MultiPlan/PHCS PPO
- Oscar
- Oxford Freedom
- Oxford Liberty
- Oxford Medicare
- Railroad Medicare
- Tricare
- UnitedHealthcare Community & State Plan
- UnitedHealthcare Core and Charter
- UnitedHealthcare EPO
- UnitedHealthcare HMO
- UnitedHealthcare Medicare
- UnitedHealthcare POS
- UnitedHealthcare PPO
- UnitedHealthcare Top Tier
- Visiting Nurse Service (VNS) Medicare
NYU Bariatrics Surgical Associates
530 1st Avenue, Suite 10S
New York, NY 10016
NYU Langone at Columbus Medical
97-85 Queens Boulevard
Queens, NY 11374
Phone: 718-261-9100
NYU Langone Brooklyn Endoscopy and Ambulatory Surgery Center
1630 East 14th Street
Brooklyn, NY 11229
Phone: 718-336-9100
NYU Bariatrics Surgical Associates
5B Medical Park Drive
Pomona, NY 10970
NYU Bariatrics Surgical Associates
745 Route 17M, Ste 770
Monroe, NY 10950
NYU Bariatrics Surgical Associates
682 Forest Avenue
Staten Island, NY 10310
NYU Bariatrics Surgical Associates
3453 Richmond Avenue
Staten Island, NY 10312
Phone: 212-263-3166
Welcome back!
As a returning patient for this doctor, please schedule an appointment using your MyChart at NYU Langone account.
Learn more about MyChart at NYU Langone.
Resident involvement does not increase complication rates in bariatric surgery [Meeting Abstract]
Creange, C R; Schwack, B; Kurian, M; Fielding, G; Ren-Fielding, C
Surgical endoscopy. 2016 March 2016. 30: S452-S452
Laparoscopic subtotal gastrectomy and roux-en-y esophagojejunostomy for gastrogastric fistula following gastric bypass [Meeting Abstract]
Sethi, M; Lee, S; Schwack, B; Kurian, M; Ren-Fielding, C; Fielding, G
Surgical endoscopy. 2016 March 2016. 30: S174-S174
The utility of esophagram and clinical indicators in detecting leaks after laparoscopic sleeve gastrectomy [Meeting Abstract]
Sethi, M; Magrath, M; Somoza, E; Parikh, M S; Saunders, J K; Ude-Welcome, A O; Schwack, B; Kurian, M; Fielding, G; Ren-Fielding, C
Surgical endoscopy. 2016 March 2016. 30: S2-S2


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13 years of experience
Accepting new patients
20950 N Tatum Blvd
Phoenix, AZ 85050 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Alaina Jose-Miller:
View the full profile to get information on:
- Qualifications
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Patient Reviews
The overall average patient rating of Dr. Alaina Jose-Miller is Excellent.
Prepare before visiting Dr. Jose-Miller
Diabetic Macular Edema Read all about Diabetic Macular Edema by visiting our Vitals patient education guides.Before Visiting Dr. Jose-Miller Learn More
Specialties & Research
Dr. Alaina Jose-Miller, MD is board certified in Family Medicine.
Education & Awards
Dr. Jose-Miller graduated from Loyola University Chicago, Maywood.
Dr. Jose-Miller has 2 hospital affiliations:
- Banner Good Samaritan Regional Medical Center
- Scottsdale Healthcare-Shea
Similar doctors nearby
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- Dr. Alaina Barbara Jose-Miller MD is a female Family Practitioner, has 13 years of experience and practices in Family Medicine.
- Where does Dr. Alaina B. Jose-Miller practice?
- Dr. Alaina Jose-Miller has 1 office location.
Dr. Alaina Jose-Miller practices Family Medicine near Phoenix, AZ.
See Phoenix Primary Care Doctors.


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Audiovox SIRPNP1 For Sirius Car & Home Satellite Radio Receiver
- Design: Compact
- Special Features: FM Transmitter
- FM Transmitter: Included
- Usage: Home Car
- Compatible Service: For Sirius
Available FromWhy are these offers here?
- Overview
- Compare Prices
Consumer Reviews
Showing 1 - 4 of 4 Reviews
Serious Ripoff
Fee for 1 year of service sirus is $175.00 for basic subscription only ($15.00 activation on top).
Read very carefully the service provides "commercial free music" only all other channels are commercial filled (badly).
The radio is the smallest part of this purchase.
... Read full review »
Good audio quality, poor design/workmanship
I received the Audiovox SIRPNP1 as a gift approximately six months ago. I also received a car kit (with FM modulator) and a home kit.
The sound quality and usability of the unit are good; since the unit is pretty large, the display is easy to read and the controls are easy to access. The... Read full review »
Audiovox SIR-PNP1
Much like several similar products on the market, the Audiovox SIR-PNP1 allows you to bring satellite radio into your home and vehicle eliminating the need for multiple subscriptions. Having owned the quirky Delphi SkyFi for XM, I can say that the Audiovox unit works extremely well. The display is... Read full review »
A few words for a great product....
I have a Kenwood head unit with Sirius in my car but you can't drive forever and sitting in your driveway a long time looks a little? Go to a store and look at the Audiovox unit and you might opt for the tuner, car and home kit if you don't mind a little bulk. I purchased the Audiovox home unit and... Read full review »
Available From
Smart Buy! Lowest price from a Trusted Store
Sealed Audiovox Satellite Radio Shuttle Receiver W/ Remote Sirpnp1
The SIRPNP SIRUS shuttle from Audiovox offers you 100 streams of SIRIUNS programming in your comfort zone, in your home or car. It is compatible with Audiovox home and car kits, and allows you to transfer the shuttle between your home and car.
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Scoubidou - Klutz (Mixed media product)April Chorba
Mixed media product Published: 02/05/2013
- In stock
Click & Collect From your local shop
Make your own bracelets, keyrings and ponytail holders with over 36 metres of Scoubidou. Scoubidou shows beautiful ways to braid, weave, and knot the round, hollow and pliable cord. There's enough cord to make all 12 projects in the book, such as bracelets, bag clips, flip-flops decorations and more. The book contains clear instructions for each project, photos and further inspiration
Publisher: Scholastic US
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text: Mining Anglo American chief quits Add to ... Reuters Published Friday, Oct. 26, 2012 9:15AM EDT Last updated Friday, Oct. 26, 2012 9:16AM EDT Anglo American's Chief Executive Cynthia Carroll stepped down on Friday after more than five years in the job, under increased pressure from investors over the miner's lagging share price and continued dependence on troubled South Africa. Hayley Platt reports. Watch More Video: I've been hiding money from CRA – how do I come clean? Survey paints grim picture of UK economy GE swings to profit from loss Canadian inflation flat as retail sales reach record high U.K. economy slows after shock referendum Market Call Tonight: Top Picks from Sentry Investments' Mason Granger Personal Investor: The awesome power of the 'amateur' investor Husky Q2 loss overshadowed by pipeline spill Pokemon GO goes to Japan Precision Drilling CEO sees optimism in the energy sector Saskatchewan Premier hopping mad over Alberta beer tax Conference Board cuts Canada growth outlook to 1.4% TPP to hurt Canada's auto sector: Report Greece urged to stay on reform path How the Blue Jays helped Rogers hit a home-run in Q2 Fort McMurray rental market to surge after wildfires, CMHC says Tesla's ambitious 'master plan' Market Call Tonight: Top picks from Arrow Capital's Veronika Hirsch Rogers beats expectations, with media division profits up ECB stands pat in first policy meeting since Brexit vote Comments AA More Related to this Story Stocks Video: Analyst upgrades and downgrades


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Maritime Today
The Maritime Industry's original and most viewed E-News Service
The new Wärtsilä REvolution system is a digital management system that controls, monitors, records and analyses the performance of seals autonomously in real time,
As part of the ongoing Blue Star Delos Renewable Energy Innovation Project, Eco Marine Power (EMP) stated that the Aquarius Management & Automation System (MAS)
MSC Mediterranean Shipping Company has reached an agreement to back French start-up TRAXENS, a developer of cargo logistics solutions and creator of a container monitoring and coordination system.
China's foreign minister has asked the U.S. secretary of state John Kerry to support the resumption of talks between China and the Philippines over the South China Sea,
U.S. Secretary of State Kerry says backs bilateral talks; Philippines says dispute does not involve United States.
U.S. Secretary of State John Kerry said on
Piracy and armed robbery at sea has fallen to its lowest levels since 1995, despite a surge in kidnappings off West Africa, according to a new report from the


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Edvard J. Soosis horrible card player sucks luck out of anyone who is around him or says his name.
School sucked, it was a total Soosis. That guy is a complete soosis(lucksack)
by Russell March 10, 2005
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text:
X-Men: Days of Future Past (US - DVD R1 | BD RA)
We now have full specs on multiple releases of the summer movie hit...
Starring: Old and Young Mutants
Released: 14th October 2014
Further Details:
Twentieth Century Fox Home Entertainment has finalized specs and a release date for Bryan Singer's
X-Men: Days of Future Paston 3D Blu-ray Combo Pack (3D Blu-ray/Blu-ray/DVD/UltraViolet), Blu-ray Combo Pack (Blu-ray/DVD/UltraViolet), and DVD.
The 3D and 2D Blu-ray Combo Packs will feature:
- 2.40:1, 1080p Video
- DTS-HD MA 7.1 and Descriptive Audio 5.1 English, Dolby Digital 5.1 French and Spanish Audio
- English SDH and Spanish Subtitles
The DVD will feature:
- Anamorphic 2.40:1 Video
- Dolby Digital 5.1 and Descriptive Audio 5.1 English, Dolby Digital 2.0 French and Spanish Audio
- English SDH and Spanish Subtitles
According to the press release, every release will include the following extras:
- Deleted Scenes with Optional Audio Commentary by Bryan Singer
- Gag Reel
- Kitchen Sequence
- Classification: M
- X-Men: Reunited
- Double Take: Xavier & Magneto
- Sentinels: For A Secure Future
- Gallery: Trask Industries
- Second Screen App
- Theatrical Trailers
Original Post
Amazon.com has another super-early preview of an exclusive Blu-ray collection available on their website. Those hoping for something as hilarious as the Amazing Spider-Man 2 Electro head might be disappointed by
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Dorothea Kent (June 21, 1916 – August 23, 1990) was an American film actress. She appeared in 42 films between 1935 and 1948. In addition to her credited roles, she also had roles in 6 other films, including her last role in the 1948 film The Babe Ru...th Story.
Connect any celebrity with Dorothea Kent to see how closely they are linked... romantically!


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July 4th Holiday Weekend Recap
The club had a good turnout for the Commodore's weekly Friday night cocktail party. 18 members enjoyed the pleasant cocktail hour(s) on the upper deck above the pool. The view can't be beat! On Saturday, the club hosted the Old Point Comfort Yacht Club who were visiting YRYH for the … Continue reading


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New Jersey's school bus failure rate continues at almost half of the 24,000 vehicles each year, according to the Motor Vehicle Commission's updated school bus report card.
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Need help/advice ASAP
Comments (9)
My daughter did that after OHS---after the syringed her snot out of her nose and got rid of some of the wires and put the bed down to lay flat she was able to position herself into the sleep position that she needed to breathe the way her body automatically knew how to get the right amount of oxygen.
You can also suggest bringing the oxygen home for her at night and then having someone come in to test her weekly or so until she can get off.
Kristie --- Mother of 3 Tyler 12, Zachary 6 and Faith (4/10/11) (T-21 AV REPAIRED-YEAH)
Is there a pediatric ENT looking at her?
Vivianne (left handed, 16), Lilianne (curly hair, 11), and Violette (Down syndrome, 9)
my blog http://yomammamamma.blogspot.com/
Is she just desatting at night or while sleeping? Is she on room air while she is awake? If it is just while she is sleeping I would ask if she can go home on oxygen. If her lungs sound clear otherwise from a pneumonia stand point. Have they done another chest xray?
Our pulminologist wasn't going to make us stay in the hospital longer than a week if Ruby was just desatting while sleeping. He was going to send us home with oxygen.
Gl and I hope your dd gets to go home soon!
DD Kaitlyn (6/06) and DD Allison (2/12, T21)
Dale used to destat during sleep as well but it was before his OHSx2. He hasn't been in the hospital in a long time so I don't have a clue about him now. Just know he sleeps well.
I agree, NICU stays do suck.
Tammy-I'm the pink in this ALL BLUE house.
Wife to Bob, Mom to Dale 11 (DS), William 8(ADHD), Samuel 5, Wallace (FUR CAT BOY)


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Enter your stay dates and any discounts you qualify for to see Henderson, TN rates found only on HotelPlanner!
Find accommodations in Henderson with the hotel list provided below. Search for cheap and discounted hotel and motel rates in or near Henderson, TN for your business or personal leisure travel. Discover the most popular Henderson Tennessee hotel/motel rooms. Review the Henderson hotel list below to find the perfect lodging. We also have a map of the Henderson hotels. Planning a group? Lock in Henderson Group Hotel Rates
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The Miami Leaders program develops the skills and management competencies of emerging nonprofit leaders in Greater Miami. Through the program, we award grants that enable them to attend premier executive education programs around the country.
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Stay Up-to-Date with The Aging Experience
The Aging Experience-Just Rock It!
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What We Can All Learn About Living in the Present
Brilliant Disguise – Bruce, HB2 and LGBT Elders
Aging in Place in an Uber Economy – Is it safe?
The Discrimination Caregivers Can Face In The Workforce


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Losing weight requires you to change your current eating pattern and habits. To make this process easier, here are 16 of our best diet tips to help you lose weight and maintain the weight loss!


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Technological Leadership and Productivity Leadership in Manufacturing Since the Industrial Revolution: Implications for the Convergence Debate
The United States has been the labor productivity leader in manufacturing since the early nineteenth century despite changes in technological leadership from Britain to the United States and then to Germany and Japan. U.S. productivity leadership is based on the more widespread use of mass production rather than craft production methods, determined by resource and factor endowments and demand patterns. The two systems can coexist so long as the technologically lagging system imitates and adapts. Changes in the relative dynamism of the two systems explain changes in technological leadership but without necessarily leading to changes in productivity leadership. Copyright 1994 by Royal Economic Society.
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- July 23: Mitsubishi Recalls Vehicles That Can Lose Control recalls | 2 days ago
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These authors contributed equally to this work.
Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures
Version of Record online: 19 MAY 2011
DOI: 10.1111/j.1471-4159.2011.07289.x
© 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry
Journal of Neurochemistry
Volume 118, Issue 1, pages 140–152, July 2011
Additional Information
How to Cite
Hyzinski-García, M. C., Vincent, M. Y., Haskew-Layton, R. E., Dohare, P., Keller, Jr., R. W. and Mongin, A. A. (2011), Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures. Journal of Neurochemistry, 118: 140–152. doi: 10.1111/j.1471-4159.2011.07289.x
Publication History
- Issue online: 10 JUN 2011
- Version of Record online: 19 MAY 2011
- Accepted manuscript online: 23 APR 2011 12:25AM EST
- Received November 30, 2010; revised manuscript April 1, 2011; accepted April 19, 2011.
- astrocytes;
- cell swelling;
- glutamine;
- glutamate-glutamine cycle;
- glutamine synthetase;
- hypoosmotic
J. Neurochem. (2011) 10.1111/j.1471-4159.2011.07289.x
In our previous work, we found that perfusion of the rat cerebral cortex with hypo-osmotic medium triggers massive release of the excitatory amino acid L-glutamate but decreases extracellular levels of L-glutamine (R. E. Haskew-Layton et al., PLoS ONE, 3: e3543). The release of glutamate was linked to activation of volume-regulated anion channels, whereas mechanism(s) responsible for alterations in extracellular glutamine remained unclear. When mannitol was added to the hypo-osmotic medium to reverse reductions in osmolarity, changes in microdialysate levels of glutamine were prevented, indicating an involvement of cellular swelling. As the main source of brain glutamine is astrocytic synthesis and export, we explored the impact of hypo-osmotic medium on glutamine synthesis and transport in rat primary astrocyte cultures. In astrocytes, a 40% reduction in medium osmolarity moderately stimulated the release of L-[3H]glutamine by ∼twofold and produced no changes in L-[3H]glutamine uptake. In comparison, hypo-osmotic medium stimulated the release of glutamate (traced with D-[3H]aspartate) by more than 20-fold. In whole-cell enzymatic assays, we discovered that hypo-osmotic medium caused a 20% inhibition of astrocytic conversion of L-[3H]glutamate into L-[3H]glutamine by glutamine synthetase. Using an HPLC assay, we further found a 35% reduction in intracellular levels of endogenous glutamine. Overall, our findings suggest that cellular swelling (i) inhibits astrocytic glutamine synthetase activity, and (ii) reduces substrate availability for this enzyme because of the activation of volume-regulated anion channels. These combined effects likely lead to reductions in astrocytic glutamine export in vivo and may partially explain occurrence of hyperexcitability and seizures in human hyponatremia.


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Doc Rivers has quickly developed quite an affinity for Keyon Dooling, the Celtics' smile-happy, mediocre backup point guard with a penchant for making the right play. (Boston Herald)
"I love him," Rivers said. "I love him. I think we couldn't have picked a better guy to back up (Rajon) Rondo — with his spirit, his knowledge, being a veteran, the fact he can make open shots. And he challenges Rondo every day in practice.
"Rondo has laughed about it several times, 'This guy doesn't back up at all.' And it's been great. They go at each other in a positive way, and I think it's the first time Rondo's had that, and it's been great for him."
Boston'Äôs backup point guard position in the Big Three era had been a rotating carousel of crazy. First there was Eddie House, a pro'Äôs pro, yet one of few point guards in NBA history who dribbles like he has ping pong paddles taped to his hands. Then there was Sam Cassell, the veteran known for his loud mouth and oversized testicle dance, who wasn'Äôt nearly a great shooter by the time he signed with Boston but fired away like he needed to reach a shot quota. Cassell gave way to Stephon Marbury, who loves eating¬ÝVaseline, smokes marijuana on camera, believes selling ****** sneakers for $10 apiece might actually be profitable, and has a tattoo on the side of his face. After Marbury came Nate Robinson, who'Äôs jovial and laugh-happy, but believes a pull-up 30-footer qualifies as a good possession, occasionally runs around in Shaq'Äôs size 23'Ä≤s and probably needs to shop at Baby Gap, at least when he doesn'Äôt just wear Earl Boykins'Äô hand-me downs. Robinson was traded away and the Celtics later acquired Delonte West, a gritty left-handed player with playmaking skills on both ends of the court, who suffers from bipolar disorder, fought Von Wafer almost immediately after beginning Celtics training camp and got a job moving furniture during the NBA lockout.
Don't think I'm badmouthing all these former Celtics point guards. I love West and mean no disrespect to his mental illness, appreciate Robinson's charm (if not his shot selection), believe Marbury was on his best behavior in Boston, adore Eddie House and get a kick out of Sam Cassell, at least when he's not shooting ten shots in four minutes while Doc Rivers watches from the sideline with an "I know I can still do better than this, and I haven't played in the NBA since 1996″ look. I'm just saying that Boston's bench has hardly been the place to find normalcy, at least if you're looking for a level-headed point guard who easily fits in.
Until Dooling. He's not flashy. He doesn't shoot a great percentage from the field. He isn't a former All-Star (like Marbury and Cassell), never won the dunk contest (Robinson), won't threaten to break Boston's three-point accuracy record (held by House) and doesn't have West's starter-level playmaking skills. Dooling DID fight Ray Allen once, but it was five years ago and completely out of character for both men. The fight was probably the most highly-publicized moment of Dooling's career, a career that to date has been mostly bereft of signature moments. Dooling, despite a colorful personality that includes a smile that sometimes seems omnipresent, is a bland player, one who thrives on making the simple play rather than the highlight-reel one, perhaps because he's mostly incapable of making plays that are worthy of SportsCenter.
After seeing all different types of crazy backing up Rajon Rondo through the last few seasons, I imagine bland is just what Doc Rivers ordered. Dooling isn't going to score 30 points in any game this season. He's not going to inspire memories of Bob Cousy. He won't make anybody's list for Sixth Man of the Year. He's just going to show up to work, play his role without complaint, and act as the second unit's leader while doing it. And if he's not as talented as the other backup point guards Boston has had in recent years, Rivers is okay with that.
"It's always a problem, role players understanding they're role players," Rivers said. "We've got a group of guys who clearly know who they are. But they're also very comfortable in that. They think they can play as well as the starters, but they accept where they're at. I think Chris (Wilcox) and Brandon (Bass) are learning the stuff.
"Keyon's been off the charts. He's been like he's been here forever defensively. He protects the nail (the middle of the free throw line); he does everything for us. So he's been the easiest by far. At times I think he's been (in) front of some of our guys who've been here. He's been good, and everybody else is just kind of learning."
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I haven't been able to get WordPress to install locally for the first time.
I have xampp running. I created a database 'ferncreek' in phpMyAdmin. I made sure that the user 'root' has all privileges. I modified the wp-config-sample.php file to show my database name, database username, and password (I also tried this with the password field blank) and saved it as wp-config.php.
I went through the wp installation process, and it said that it couldn't access the database. I try to go to http://localhost/ferncreek/ and get a "page not found" error message.
Am I overlooking something?


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Decimalisation is 25 years old today and despite protests and grumbles at the time, few people now mourn the passing of pounds, shillings and pence, according to a new report.
The NOP survey, commissioned by the National and Provincial Building Society, shows that "old money" has largely been forgotten.
Three-quarters of the over-40s surveyed said they preferred the post- 1971 decimal system. Only 25 per cent remembered that decimalisation was introduced in 1971 although men (27 per cent) had slightly better powers of recall than women (23 per cent).
Less than half correctly recalled that there were 240d to the old pound - men again scoring higher than women.
Britons have a slightly better recollection of the coins themselves with 58 per cent of the 1,000-strong sample remembering that the tanner was the popular name for the sixpence and 54 per cent recalling that the florin was two shillings.
Although the guinea was rarely used and rarely seen, even in 1971, it is remembered more easily than any other coin in the old system with two-thirds knowing that it was equivalent to 21 shillings.
"Britain had operated the pennies and shillings system since 1849, so the prophets of doom in 1971 predicted that we would never get used to decimalisation and that the country would quickly crumble because we wouldn't be able to get to grips with all the new coins," Phil Read of N&P said. "But not only did we soon get used to the decimal system, most people appear to have forgotten we ever had sixpences and shillings."
Today, the Royal Mint and the Bank of England are opening an exhibition at the bank's museum which will include some of the original decimal coin designs, including a 50p note which was never circulated and publicity material by the Decimal Currency Board.
Decimal currency underpants, playing cards and dusters are also displayed.
For those who never managed to say goodbye to pounds, shillings and pence, valuable coins could be lurking in your home. A spokesman for the leading coin merchant, A D Hamilton, said: "Anything minted before 1947 has silver content and is worth twice its face value."
Alternatively, The King's Head pub, in Islington, north London, remains one of the last bastions of pre-decimal Britain with prices displayed and quoted in pounds, shillings and pence and takings deposited in an "old money" cash register.
Dan Crawford, the landlord, grudgingly accepts "new money" but occasionally - much to his delight - receives tanners, bobs and florins over the bar.
Prices then and now
Item 1971 1996
Milk 6d (2.5p) a pint 50p a litre
Valentine card 1/6d (7.5p) pounds 1.50-plus
First-class stamp 5d (2p) 25p
Two-bedroom house pounds 7,000 pounds 50,000
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Obamacare May Cost Small Business 'Whiners' 65% of Annual ProfitsBreitbart
Mar. 22, 2013
German Officials Respond to Migrant's Axe Attack by Calling for 'Mandatory Islam Classes'
Finland: Man Thrown in Prison For Using "Excessive Self-Defense" Against Home Invaders
Steve King Doubles Down: Idea Every Culture is Equal "Not Objectively True"
'The Economist' Celebrates British People Becoming A Minority In Their Own Country
Black Lives Matter Protesters Block Bridge During Child's Medical Emergency
Today the NY Times has a case study on the cost of Obamacare to one small business. The business in question is Baked in the Sun, a California baker with 95 employees.
Read More


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|Publication number
|Publication type
|Application number
|Publication date
|Jan 20, 1987
|Filing date
|Jan 28, 1985
|Priority date
|Jan 28, 1985
|Fee status
|Also published as
|Publication number
|William A. Slusarchyk, William H. Koster
|Original Assignee
|E. R. Squibb & Sons, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (4), Non-Patent Citations (5), Referenced by (6), Classifications (17), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
U.S. Pat. No. 4,337,197, issued June 29, 1982 describes O-sulfated β-lactam hydroxamic acids having antibacterial activity. Preferred compounds, as disclosed by the patent, have the formula ##STR1## wherein R'1 is acyl, R'3 and R'4 are the same or different and each is hydrogen or alkyl, and M.sup.⊕ is hydrogen or a cation.
Several processes for preparing the above compounds are described including a process which utilizes an intermediate having the formula ##STR2## wherein A' is a nitrogen protecting group and Y' is benzyl or pivaloyl. As described in the patent, the hydroxyl group of the above intermediate is converted to a leaving group, using, for example, a classical reagent such as methanesulfonyl chloride. The fully protected compound has the formula ##STR3## (L' is a leaving group), and can be cyclized by treatment with base, e.g., potassium carbonate, to yield a compound having the formula ##STR4##
Alternatively, the patent describes the single step cyclization process which comprises treatment of an intermediate having the formula ##STR5## with triphenylphosphine and diethylazodicarboxylate.
It has been found that a pharmaceutically acceptable salt of [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(Sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]acetic acid, the compound having the formula ##STR6## is a superior antibacterial agent.
To prepare [3S(Z)]-2-[[[2-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]acetic acid, it was desirable to improve upon the process described in U.S. Pat. No. 4,337,197, and set forth above in the Background of the Invention. It has been found that a compound having the formula ##STR7## can be sulfonated to yield a compound having the formula ##STR8## Compounds of formula III are novel intermediates, and as such, they form an integral part of this invention. Cyclization of a fully protected compound of formula III yields the useful intermediate having the formula ##STR9##
As used in formulas II, III and IV, and throughout the specification, the symbols are as defined below.
A is benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, t-butyloxycarbonyl, o-nitrophenylsulfenyl or triphenylmethyl;
R1 and R2 are the same or different and each is alkyl of 1 to 4 carbons;
R3 is benzyl, p-nitrobenzyl, benzyloxymethyl, 2-methoxy-2-propyl, 2-ethoxy-2-propyl, tetrahydropyran-2-yl, 2-trimethylsilylethyl, t-butyldimethylsilyl, or t-butyldiphenylsilyl;
The pharmaceutically acceptable salts of the compounds of formula I include those basic salts formed with inorganic and organic cations. Such salts include ammonium salts, alkali metal salts such as sodium and potassium salts, alkaline earth metal salts such as calcium and magnesium salts and salts derived from organic bases such as dicyclohexylamine, benzathine, hydrabamine, N-methyl-D-glucamine.
The compounds of formulas I, VI, and IX are pictured as acids. They can also exist, however, as zwitterions (internal or inner salts), and these are also included within the language "pharmaceutically acceptable salts" and the scope of this invention.
Pharmaceutically acceptable salts of the compound of formula I can be used to combat gram-negative bacterial infections in mammalian species, such as domesticated animals (e.g., dogs, cats, horses and the like) and humans. The salts are particularly suitable for oral administration, but all modes of administration which have been used in the past to deliver penicillins and cephalosporins to the site of the infection are also contemplated.
For combating a gram-negative bacterial infection in a mammalian host, a pharmaceutically acceptable salt of the compound of formula I can be administered to a mammal in need thereof in an amount of about 1 mg/kg/day to about 350 mg/kg/day, preferably about 10 mg/kg/day to about 100 mg/kg/day.
For oral administration, a pharmaceutically acceptable salt of the compound of formula I can be formulated as a tablet, capsule, or solution or suspension in an aqueous vehicle.
Pharmaceutically acceptable salts of [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]acetic acid can be prepared following the methodology described in U.S. Pat. No. 4,337,197, issued June 29, 1982 (utilizing the intermediates described above in the Background of the Invention). This process has been improved.
Conversion of the hydroxyl group of a compound having the formula ##STR10## to a leaving group is complicated by the fact that the compound is a tertiary alcohol. It has been found that if a compound of formula II is sulfonated using a pyridine (or substituted pyridine) sulfur trioxide complex having the formula ##STR11## wherein m is 0, 1, 2 or 3, the reaction will give a compound having the formula ##STR12## in high yield. The pyridine-sulfur trioxide complex reacts preferentially with the hydroxyl group (as desired).
The sulfonation reaction can be run in an organic solvent such as pyridine, mono-, di- or trimethylpyridine, chlorinated hydrocarbons (e.g., dichloromethane, 1,2-dichloroethane), acetonitrile, dimethylformamide and dioxane. The reaction will preferably be run at about 0�-100� C.
Base mediated cyclization of a compound of formula III yields the corresponding intermediate having the formula ##STR13## The base is preferably an inorganic base such as an alkali metal carbonate (e.g., sodium carbonate or potassium carbonate) and should be present in excess (about 2 to 10 equivalents per reactant of formula III). The reaction is preferably run in an aqueous organic solvent mixture. The organic component can be ethyl acetate, acetonitrile, acetone, methyl ethyl ketone, methyl propyl ketone, methyl butyl ketone, methyl isobutyl ketone, 1,2-dichloroethane, pyridine, or mono-, di- or trimethylpyridine.
An intermediate of formula IV can be used to prepare an antibacterial agent which is a salt of a compound having the formula ##STR14## As described in U.S. Pat. No. 4,337,197, the protecting group "R3 " can first be removed from an intermediate of formula IV to yield the corresponding hydroxamic acid having the formula ##STR15## The reactions used to remove the various "R3 " groups are known in the art and will, of course, depend on the particular "R3 " group.
Sulfonation of a compound of formula VII yields the corresponding compound having the formula ##STR16## or a basic salt thereof, and can be accomplished by reaction with a complex of sulfur trioxide with pyridine, dimethylformamide or 2,6-lutidine.
Removal of the 3-amino protecting group "A" from a compound of formula VIII yields the corresponding key intermediate having the formula ##STR17## The procedure used for the removal of the protecting group will depend on the particular protecting group.
Acylation of an intermediate of formula IX using art-recognized techniques yields an antibacterial agent of formula VI. For example, the acylation can be accomplished using a carboxylic acid, carboxylic acid halide or carboxylic acid anhydride.
The following examples further illustrate the process of this invention. The process is used to prepare [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy] acetic acid as a chiral material and as a component of a racemic mixture.
A solution of 24.84 g (106.6 mmol) of N-t-butyloxycarbonyl-D,L-3-hydroxyvaline and 16.33 g (106.6 mmol) of hydroxybenzotriazole monohydrate in 500 ml of dry tetrahydrofuran was cooled to -10� C. and 22 g (106.6 mmol) of dicyclohexylcarbodiimide was added. The mixture was stirred under nitrogen for 1 hour at 0� C. Subsequently, a solution of 13.13 g (106.6 mmol) of 0-benzylhydroxylamine in 250 ml of dry tetrahydrofuran was added over 15 minutes to the activated ester mixture, and the resultant mixture was stirred under nitrogen for 1 hour at 0� C. The insoluble material was filtered away, and the filtrate was stripped to a foam in vacuo. The foam was extracted with ethyl acetate and more insoluble material was removed by filtration. The filtrate was washed two times with 5% sodium bicarbonate solution. The organic phase was dried (sodium sulfate) and evaporated to a syrup, which was crystallized from 130 ml of isopropyl ether to give 24.7 g of the title compound, melting point 76�-78� C. The mother liquor was evaporated to a syrup (10 g), which was chromatographed on a column containing 300 g of SilicAR CC-4 packed in chloroform. The column was eluted first with 1 liter of chloroform and then with 2 liters of 2% methanol in chloroform. The latter solvent system eluted additional product (TLC Rf 0.9, chloroform/methanol, 3:1) plus an impurity that moved to the solvent front. Pooled fractions were evaporated in vacuo to a syrup (8 g), which was crystallized from 25 ml of isopropyl ether to afford another 5 g of the title compound, melting point 76�-78� C.
Dry pyridine (8.08 ml, 0.10 mole) was placed in a 500 ml round bottom flask and cooled to -10� C. under nitrogen. Trimethylsilyl chlorosulfonate (15.6 ml, 0.10 mole) was added dropwise (vigorous magnetic stirring) after which the very thick reaction mixture (due to product precipitation) was stirred for 0.5 hours at 0� C. Chlorotrimethylsilane was removed in vacuo yielding 15 g of pyridine-sulfur trioxide complex.
N-(t-Butyloxycarbonyl)-N2 -(phenylmethoxy)-D,L-3-hydroxyvalinamide (16.92 g, 50 mmol) was dissolved in 200 ml of dry pyridine, and 9.87 g (62.5 mmol) of pyridine-sulfur trioxide complex was added. The mixture was stirred at 55� C. under nitrogen for 2 hours. Another portion (790 mg, 5 mmol) of pyridine-sulfur trioxide complex was added and stirring was continued 1 hour longer. TLC (n-butanol/acetic acid/water (3:1:1)) showed only one product, Rf 0.77 (starting material moves to solvent front). The reaction mixture was stripped in vacuo to an oil. The oil was stripped from acetonitrile three times in vacuo to give crude title compound as a foam. The yield was assumed to be quantitative.
The flask containing crude N-(t-butyloxycarbonyl)-N2 -(phenylmethoxy)-D,L-3-(sulfooxy)valinamide, pyridinium salt (ca. 50 mmol) was placed in an ice bath and 400 ml of ethyl acetate, followed by a solution of 42.8 g (0.31 mole) of potassium carbonate in 90 ml of water, was added with vigorous stirring. The resultant mixture was stirred vigorously under reflux (oil bath temperature 95� C.) for 2 hours under nitrogen. The reaction mixture was cooled to room temperature and the phases were separated. The aqueous phase was extracted with 2�200 ml of ethyl acetate and all organic phases were combined, dried (sodium sulfate) and evaporated in vacuo. The oil was taken into 40% ethyl acetate/hexane (125 ml) and filtered rapidly through a 350 ml pad (10 cm) of silicAR CC-7 using 3-4 liters of 40% ethyl acetate/hexane. The filtrate was evaporated in vacuo to a solid (12.2 g). Crystallization from 50 ml of isopropyl ether gave 7.15 g of the title compound, melting point 110� C. Evaporation of the mother liquor gave 4.75 g of gummy solid containing ca. 15% additional compound on the basis of the 1 H nmr spectrum.
(3�)-3-[(t-Butyloxycarbonyl)amino]-4,4-dimethyl-1-(phenylmethoxy)-2-azetidinone (8.07 g, 25 mmol) was hydrogenated at atmospheric pressure and ambient temperature in 40 ml of methanol with 0.6 g of 10% palladium on charcoal as catalyst for 2 hours. The reaction mixture was filtered through a pad of Celite and the filtrate was concentrated in vacuo. Acetonitrile was added and evaporated from the residue (twice) to yield 5.78 g of the title compound as a solid foam.
Pyridine. SO3 complex (8.02 g, 50 mmole) was added portionwise to a solution of (3�)-3-[(t-butyloxycarbonyl)amino]-1-hydroxy-4,4-dimethyl-2-azetidinone (5.78 g, 25 mmole) in dry pyridine (120 ml) at 0� C. under argon. The reaction mixture was stirred at room temperature for 2.5 hours and concentrated in vacuo. The residue was dissolved in 32 ml of a 10% acetone:.5 M monobasic potassium phosphate aqueous buffer (pH 7) solution, and the pH was adjusted to 5.2 with 1N potassium hydroxide. This was chromatographed through 270 ml of Dowex-50 (K+) resin with a 10% acetone:water solution. The appropriate fractions were combined and concentrated in vacuo to yield 13.6 g of crude product. This was further purified by chromatography through 680 ml of HP-20 resin first with 200 ml of water, then with 10% acetone:water. The appropriate fractions were combined and lyophilized to yield 7.13 g of the title compound, melting point 163�-170� C., dec.
(3�)-3-[(t-Butyloxycarbonyl)amino]-4,4-dimethyl-1-azetidinylsulfate, potassium salt (5.48 g, 15 mmole) was suspended in 20 ml of dry dichloromethane at -10� C. under argon. Anisole (6 ml) was added followed by the addition of 26 ml of trifluoroacetic acid over 2 minutes. The reaction mixture was stirred at -10� C. for 20 minutes and then concentrated in vacuo. The residue was triturated with ether (three times) and dried in vacuo to give crude title compound as a white solid.
(Z)-(2-Amino-4-thiazolyl)[[(2-diphenylmethoxy)-2-oxoethoxy]imino]acetic acid (6.52 g, 16 mmole) and triethylamine (2.5 ml, 18 mmole) were dissolved in 60 ml of dimethylformamide at -30� C. under argon. Diphenyl chlorophosphate (3.5 ml, 17 mmole) was added dropwise and the reaction mixture was stirred at -30� C. for 1.5 hours.
To the crude (3�)-3-amino-2-oxo-4,4-dimethyl-1-azetidinylsulfate prepared above, dissolved in 10 ml of dimethylformamide at 0� C., was added 6.6 ml of triethylamine. This solution was added dropwise to the above mixed anhydride at -30� C. The reaction mixture was stirred at -30� to -20� C. for 3.5 hours, and allowed to come to room temperature. Insolubles were filtered off, and the filtrate was concentrated in vacuo. The residue was dissolved in 60 ml of a 20% acetone:.5 M monobasic sodium phosphate buffer (pH 7) and the pH was adjusted to 6.0 with 2N sodium hydroxide. This was chromatographed through 300 ml of Dowex 50 Na+ resin with 20% acetone:water solution. The appropriate fractions were combined and lyophilized to dryness. The crude product was dissolved in 200 ml of wet acetonitrile and the insoluble inorganic salts were removed by filtration. The filtrate was concentrated in vacuo to yield 19.32 g of the title compound, contaminated with the acid starting material.
Crude [3�(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]acetic acid, diphenylmethyl ester, sodium salt (19.3 g) was suspended in 50 ml of dichloromethane and 6 ml of anisole at -10� C. under argon. Trifluoroacetic acid (90 ml) was added, and the reaction mixture was stirred for 1 hour, concentrated in vacuo, and triturated with ether (three times). The crude product was dissolved in 40 ml of 0.5M monobasic sodium phosphate pH 7.0 buffer and the pH was adjusted to 6.8 with 2N sodium hydroxide. This solution was chromatographed through 900 ml of HP-20 with water. The appropriate fractions were divided into two portions. The less pure portion was rechromatographed on 500 ml of HP-20. The appropriate fractions were combined with those of the first chromatography and lyophilized to yield 3.8 g of the title compound, melting point 195�-210� C., dec.
Analysis Calc'd. for C12 H13 N5 O9 S2 Na2.2.4 H2 O: C, 27.46; H, 3.41; N, 13.35; S, 12.22. Found: C, 27.46; H, 3.48; N, 13.06; S, 12.04.
A solution of N-t-butyloxycarbonyl-β-hydroxyvaline (7.02 g, 30 mmoles) in 250 ml of ethyl ether was treated with 3.63 g (30 mmoles) of S-(-)-α-methyl benzylamine and the resultant solution seeded with finely divided salt from a previous resolution. After standing 8 hours at 25� C. the resulting white solid was filtered, washed with ether and dried in air to give 4.78 g of crude title compound, melting point 137�-140� C.
Recrystallization of 8.87 g of crude material was accomplished by dissolving in 200 ml of acetonitrile at reflux and cooling to 25� C. Standing at 25� C. for 1 hour and filtering gave, after washing with acetonitrile and ethyl acetate, and drying in air, 6.81 g of the title compound, melting point 144�-146� C. A second recrystallization of the 6.81 sample from 150 ml of acetonitrile gave 6.02 g of title compound, melting point 146�-147� C. [α]D =-4.5� (C=2.0, methanol).
N-(t-Butyloxycarbonyl)-L-3-hydroxyvaline, α-methylbenzylamine salt (6.02 g, 17.0 mmoles) was shaken with a mixture of 250 ml of ethyl acetate and 100 ml of 10% potassium bisulfate and the layers separated. The organic layer was washed with water and brine, dried (sodium sulfate) and evaporated to a foam. Trituration with hexane gave the title compound as a free flowing white powder, 3.79 g melting point 116�-118� C., [α]D =+7.6� C. (C=2.0, ethyl acetate).
A sample of the title compound was converted to its methyl ester with diazomethane. Proton NMR (400 MHz) of a mixture of 5 mg of the methyl ester and 10 mg of tris[3-(heptafluoropropylhydroxymethylene)-d-camphorato], europium (III) at 0� C. showed a 95:5 ratio of enantiomers.
Deprotection of the compound (hydrochloric acid/ethyl acetate) to its free amino acid hydrochloride and comparison to the literature rotation indicated the absolute stereochemistry of the compount to be S (see Bull. Chem. Soc. Japan, 39, 2287(1966)).
Following the procedure of example 1A, but substituting N-(t-butyloxycarbonyl)-L-3hydroxyvaline for N-(t-butyloxycarbonyl)-D,L-3hydroxyvaline yielded the title compound.
Following the procedures of example 1B and 1C, but substituting N-(t-butyloxycarbonyl)-N2 -(phenylmethoxy)-L-3-hydroxyvalinamide for N-(t-butyloxycarbonyl)-N2 -(phenylmethoxy)-D,L-3hydroxyvalinamide yielded the title compound. The mother liquor from the crystallization was purified by flash chromatography on LPS-1 silica gel (eluting with 20% ethyl acetate/hexane).
Following the procedure of example 1D, but substituting (3S)-3-[(t-butyloxycarbonyl)amino]-4, 4-dimethyl-1-(phenylmethoxy)-2-azetidinone for (3�)-3-[(t-butyloxycarbonyl)amino]-4,4-dimethyl-1-1-(phenylmethoxy)-2-azetidinone yielded the title compound.
Following the procedure of example 1E, but substituting (3S)-3-[(t-butyloxycarbonyl)amino]-1-hydroxy-4,4-dimethyl-2-azetidinone for (3�)-3-[(t-butyloxycarbonyl)amino]-1-hydroxy-4,4-dimethyl-2-azetidinone yielded the title compound. After removing the volatiles, the crude residue was dissolved in 10% acetone/0.5M monobasic potassium phosphate buffer (pH7.2) and the pH was adjusted to 5.0 with 3N potassium hydroxide. This solution was subjected to chromatography on Dowex (potassium form) followed by purification on HP-20.
Diisopropylethylamine (0.54 ml, 3.09 mmoles) was added to 1.152 g (2.81 mmoles) of (Z)-(2-amino-4-thiazolyl)[[2-diphenylmethoxy-2-oxoethoxy]imino]acetic acid in 9.4 ml of dimethylformamide. The mixture was cooled to -20� C., diphenylchlorophosphate (0.59 ml, 2.81 mmoles) was added, and the resulting mixture was stirred for 1 hour to yield a mixed anhydride.
(3S)-3-[(t-Butyloxycarbonyl)amino]-2-oxo-4,4-dimethyl-1-azetidinylsulfate, potassium salt (0.98 g, 2.81 mmoles) was suspended in 7.5 ml of dichloromethane, and cooled to -10� C. Anisole (2.13 ml) was added and then 9.4 ml of trifluoroacetic acid was added. The resulting mixture was stirred at -10� C. for 1 hour. Toluene (˜5 ml) was added, and the volatiles were evaporated. The residue was triturated with hexane and anhydrous ether and evacuated to yield a white powder, (3S)-amino-2-oxo-4,4-dimethyl-1-azetidinylsulfate.
The residue was cooled to -20� C. and dissolved in 9.4 ml of dimethylformamide. Diisopropylethylamine (1.47 ml, 8.34 mmoles) was added and then the mixed anhydride was immediately added. The reaction mixture was stirred at -20� C. for 3 hours. The volatiles were removed under vacuum, the residue was dissolved in 20% acetone/water at 0� C., and the pH was adjusted to 6.5 with aqueous sodium bicarbonate.
The resulting mixture was purified by column chromatography with 20% acetone/water on Dowex 50�2-400 resin (sodium form), followed by chromatography on HP-20 (eluting with water, 5% acetone/water, 10% acetone/water, 20% acetone/water, 30% acetone/water, and 40% acetone/water) to give the title compound.
[3S(Z)]-2-[[[1-(2-Amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2oxoethylidene]amino]oxy]acetic acid, diphenylmethyl ester, sodium salt was suspended in 11.2 ml of dichloromethane at -10� C. Anisole (1.12 ml) was added, followed by the dropwise addition of 18.7 ml of trifluoroacetic acid. The mixture was stirred at 0� C. for 40 minutes. Toluene was added, and the volatiles were evaporated. The residue was triturated with anhydrous ether and evacuated to yield a white solid. The residue was dissolved in water (pH 2.75) and purified by chromatography on HP-20 (eluting with water, 5% acetone/water, 10% acetone/water, and 20% acetone/water to yield upon lyophilization 640 mg of the zwitterion of the title compound. The zwitterion was dissolved in water, and 2 equivalents of sodium bicarbonate (244 mg, 2.9 mmoles) were added (pH=5.75). Chromatography of this solution on HP-20 (eluting with water) yielded upon lyophilization 572 mg of the title compound, melting point 140�-145� C., dec.
Analysis calc'd. for C12 H13 N5 O9 S2 Na2.1.56H2 O: C, 28.31; H, 3.10; N, 13.64. Found: C, 28.31; H, 3.19; N, 13.76.
|Cited Patent
|Filing date
|Publication date
|Oct 31, 1980
|Jun 29, 1982
|E. R. Squibb & Sons, Inc.
|O-sulfated β-lactam hydroxamic acids and intermediates
|Title not available
|Title not available
|Title not available
|Floyd, J. Org. Chem., 47: 5160 (1982).
|Harding et al, J. Org. Chem., 46: 2809 (1981).
|Miller et al, J. Amer. Chem. Soc., 102: 7026 (1980).
|Shanzer et al, J. Org. Chem., 44: 3967 (1979).
|Slusarchyk et al, Heterocycles, 21: 191 (1984).
|Citing Patent
|Filing date
|Publication date
|Dec 19, 1986
|Jun 14, 1988
|E. R. Squibb & Sons, Inc.
|Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid
|Aug 15, 1989
|Nov 27, 1990
|E. R. Squibb & Sons, Inc.
|Process for preparing 3-hydroxy 2-keto acids
|May 10, 1991
|Sep 1, 1992
|E. R. Squibb & Sons, Inc.
|[3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
|Dec 7, 2006
|Dec 2, 2014
|Basilea Pharmaceutica Ag
|Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
|Dec 7, 2006
|Mar 4, 2010
|Eric Desarbre
|Useful Combinations of Monobactam Antibiotics With Beta-Lactamase Inhibitors
|Apr 3, 1989
|Oct 11, 1989
|E.R. Squibb & Sons, Inc.
|[3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]-amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
|U.S. Classification
|540/355, 546/348
|International Classification
|Cooperative Classification
|European Classification
|Sep 25, 1986
Owner name: E. R. SQUIBB & & SONS, INC., LAWRENCEVILLE-PRICETO
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:DENJNEKA, TAMARA;SLUSARCHYK, WILLIAM A.;KOSTER, WILLIAMH.;REEL/FRAME:004608/0067
Effective date: 19850326
Owner name: E. R. SQUIBB & & SONS, INC., LAWRENCEVILLE-PRICETO
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DENJNEKA, TAMARA;SLUSARCHYK, WILLIAM A.;KOSTER, WILLIAM H.;REEL/FRAME:004608/0067
Effective date: 19850326
|May 15, 1990
|Fee payment
Year of fee payment: 4
|Jun 20, 1994
|Fee payment
Year of fee payment: 8
|Jan 17, 1999
|Lapse for failure to pay maintenance fees
|Mar 30, 1999
|Expired due to failure to pay maintenance fee
Effective date: 19990120


text:
|32 Reviews
|Property type
|Minimum Stay
|2 - 3 nights
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Come "Live the dream" at Black Knight Vineyard House located on top of Taylor Mountain.
Majestic view, tranquil, private, vineyards to explore.
********June 3-5 special******** contact for more information
Private 60 acres, 32 of them is vineyards, 3 mountain tops to climb with unique 360 degree views of wine country and distant mountains.
Rejuvenate in the private six-person Spa that has 50 jets plus it has a lounging seat. It is kept at an inviting 100 degree year round and overlooks the valley.
The 1600 sq.ft. vineyard house offers: A Full Kitchen, Living Room, Den, 3 bedrooms, and 2 full bathrooms plus hot-tub and pool.
The full-kitchen is completely outfitted for cooking and entertaining. An extensive collection of wine and cookbooks to inspire any chef.
Master Suite has a full sitting and dining area A California king bed, a full bathroom with rain shower and Jacuzzi tub.
There are two bedrooms with queen European pillow beds. One has a private deck that leads to the pool and hot-tub.
The den can convert to a private bedroom for any extra guests with a full size futon.
There is a 42" High-definition Direct TV located in the family room. In the master suite a 32" Also, an extensive collection of DVD's, books and games for all ages.
Numerous outdoor dinning areas. In the backyard is a stainless steel grill with searing plate for the master outdoor chef.
Watch the rescued horses graze in nearby pasture or greet the neighboring cows that occasionally take shade under trees in the backfields. Deer, California quails, ducks, a Hoot owl, wild turkey, chickens and 2 lovable Labs can easily be found.
Our chickens provided fresh eggs. In-season pick: blackberries, peaches, apples, apricots and plums. Lavender, Rosemary and Bay are located around the property and in the backyard of the vineyard house.
The Petaluma Wind gap provides a constant and cool breeze also occasional fog that is picturesque.
Solar power is powering the vineyard house.
Quite hours (10:00 P.M.-7:00 A.M.) to be observed by all guests
This Bennett Valley location has all the romance of the country and a vineyard but is also only minutes to Santa Rosa, Rohnert Park and Glen Ellen. This central location is ideal for day excursions to all of Sonoma valley and Napa Valley wine tasting. A quick drive to 101 and you can also be on your way to San Francisco for the day and evening. It does not come more convenient or more centrally located.
Relax and enjoy the magnificent views of the valley below and the mountains in the distance. Come "Live the dream" at Black Knight Vineyards.
We purchased this property seven years ago after searching for more than two years. The entire family felt it was time to perhaps create something for the family. The kids(3) and I also required that it be something that my husband (a business turnaround specialist)loved for a change. He has been a wine fanatic for his entire life. We had a family meeting and agreed that we were all in for the adventure in Wine. For my part, leaving the design painting business was an easier choice since the market was slowing rapidly.
The first year was more work than anyone expected. With 60 acres of land, 25 acres of grapes, two houses, two huge barns and a couple small barns, we had more to do than we could get to. One of our top priorities was to rehab the grandmother's house on one of the secluded peaks. It was redesigned right from the begining as a vacation rental.
We wanted this place to be a representation of our life. It is filled with furniture and art collected all over the US and the World. It is so peaceful here that it just called out for a spa. We especially like the spa perched on the top of the hill overlooking the valley to the west. Comfort was also high on our list – We think you will agree that it has turned out great and is unique.
DeAnne Black
DeAnne Black purchased this house in 2007
From the start we were interested in some type of vacation rental or B&B as part of the business. About half of the properties we considered had potential for a vacation rental. Our bigger decision was were to start with the wine business. It is a complex business and very capital intensive. We choice to start with grapes since great wine must start with great fruit.
Sonoma is one of the top wine regions in the world. It is also one of the most beautiful locations in the US. We are privileged to have one of the best views around and we can share this with you.
The bonus of this location is that while we have a peaceful, rural vineyard, we are very centrally located with easy access to Santa Rosa, Rohnert Park and ALL the wine areas.
It really is the best of all worlds.
As our guest you are welcome, and encouraged, to explore the vineyards. Walk, run, picnic or bike, it is a new vista on each of the three peaks on the property.
Many guest are looking forward to sampling the wine region and the wines of Sonoma a second to none. Our central location is excellent for multiple day trips in different directions, all easy to get to.
Napa is 30 mins awasy and San Francisco is 45 mins away and a direct route over the Golden Gate Bridge.
We had a wonderful time here - just wound up being one night. Perfect for two couples. Three of the four of us did the first Levi's Grandfondo in Santa Rosa. Needless to say, the cold pool, hot tub and sauna were all food for the bones and muscles! The view is amazing! We also enjoyed hearing the wind among the trees. A walk through the vineyard is a must. Another great view up above the Merlot & Pinot grapes. If you are lucky - Mitch will let you barrel taste his private stash! Yummy - We loved the Zin he had in a 1/4 barrel. We enjoyed talking with DeAnne and Mitch and hearing their story of how they got here - cheers to them for taking a risk we have all thought about.
We hope to return!
thanks to our new Vineyard family of Mitch and DeAnne and the dogs and Chickens and Roosters....Russell Crow..I still chuckle......we went to celebrate our anniversary and ended up joining a new family.
I call it the Sonoma equivalent of working on a dude ranch! We were given a tour of the property, learned a ton about the region and specifically the vineyard and how the natural makeup of the area attributed to creating such rich and complex grapes. Had a little work-out doing the "press-down" twice/day on the 2015 Merlot and loved every second of it. Oh and of course, enjoyed watching the sunset and moon rise while
sampling some of the most wonderful wines! I have never tasted a Chardonnay like this in all of my samplings...even in Australia....so different...but so perfect!
We stayed in grandmas house...and boy does gramdmas house have a great view !!! A couple of things might differ slightly from the pictures here, but the best ones of the vineyard and valley views especially from the Hot Tub are True to life!! If you are looking for a 5 star-antiseptic hotel..this isn't it! The home is "real", "comfortable", "functional" and a place to come home to every night after your day's adventures.
We loved being part of something that we know will continue to grow into Mitch and DeAnne's dream as the years progress and we look forward to being the first members of the Black Knight Vineyard Wine club...hint hint DeAnne !!
cheers to you DeAnne and Mitch and best of luck chasing your dreams!
A group of 8 of us booked the house for our getaway to wine country and this experience absolutely made our trip! The views from the house were spectacular - whether looking out on Sonoma County or down at the vineyard. DeAnne was a fantastic host - she invited us to help harvest the grapes, offered us a private wine tasting from their selections, and gave us more knowledge than we ever would have gained just going to the wineries in town.
The space was definitely tight for 8 people (the futon really only sleeps 1 comfortably, so someone had to sleep on the the couch), but the experience made up for it. We even decided to grocery shop and eat in to enjoy the property more instead of eating out every night. Overall, our stay at Black Knight Vineyards was incredible and I will be recommending this to everyone I know planning a trip to Sonoma.
Rented the home with another couple for a wine getaway. Location looked good on VRBO. Could not wait to relax in the jacuzzi and grill some food and just plain relax with some great wine. When we got to the home we found the owner cleaning the pool. It was green and had so much algae that it needed to be shocked. You could not swim in it. Pine cones and debris all around the pool area and deck. We went to fire up the gas grill, and found it to be very dirty with a birds nest inside. Cleaning? So we swept the patio area spent 20 minutes cleaning the grill and made dinner. House was not very clean. Most of the glasses were dirty and dishes needed to be washed by hand. The bedrooms were clean and the bathrooms were fairly clean but not like a hotel. The outdoor furniture was very dirty and dusty. We sat on dirty chairs at night and looked at the view of the valley.We opened the cover to the Jacuzzi and it was not clean, therefore we did not use it.
The location is pretty remote and not very close to the vineyards. We were never offered a tour of vineyard and when we inquired we got a let me get back to you in a couple of days. Not very impressed. Never tried the wine. One might think they would offer a bottle on the house, but no such luck. Dogs were cute but bothered us a lot and owners thought we wanted to play pinecone with them which we did not.
The security deposit was a total mixup, with us giving them a check, they cashed it and forgot to tell us then we sent another and they generally had no idea what transactions each of the other partners did. Not a good value for the money and the cleaning consisted of mother daughter cleaning team. Please let a professional clean the home.
We liked the view and the general layout of the home. Rooms were pretty nice but it needed to be a lot cleaner. They need to go see other VRBO homes. We really wanted to see the wine operation, but felt the owners had no desire to show us, so we hit up some awesome vineyards near Healdsburg and had a blast. What a disappointment, as we really wanted to have a great experience.
I looked at many rental houses (East Coast to West Coast) and I finally decided to book this one! It was not only a great house but also the perfect location. My 5 guests (some I've known since elementary school) and I couldn't have been more pleased with our stay at Black Night Vineyard. We all were very comfortable. The weather was a little cool but being in the hot tub every night for sunset was perfect. The owners were so wonderful. We all played tennis ball, stick and pinecone with the owners' two Labradors, who were very cute and playful. Also in the mornings we walked outside where you can see and hear the rescue horses from the neighboring property. Each morning we had fresh eggs and we even picked blackberries, which were all over the vineyard. Our last night in California we had a glass of wine in our hotel and I wish I was drinking some of Black Knight's Pinot Noir instead. My palette for Chardonnay and Pinot has definitely changed after buying some of the owner's wine. The owners were so nice. My friends all said that their favorite experience was learning more about the vineyard and the wine making process at Black Knight from the owners, and of course I agree with them!
We (5 adults & 2 children) stayed at Black Knight the week of the 4th of July, 2014 (sorry I'm late!). Wonderful views, gracious hosts and lovely place to stay. The new master suite was a nice little oasis for hubs & me, with its own bath, seating & eating area, and patio overlooking the vines on the hillside of the property. The front yard, with its view and lounge chairs, quickly became our go-to place to read, relax, enjoy the view & the wine. There's a pond on the property downhill of the winery, and you could watch all the various animals at the watering hole. A family of quail ignored us and wandered around the yard and slope down to the pond. I'm sure they love eating the grapes. The pool side of the house, where the BBQ grill is, is on the shadier side of the house, with hills and cows (and deer and quail), and was nice in the July heat. We used the pool (unheated, and a bit chilly with the shade), but did not use the hot tub with the kiddos.
The house is nicely appointed, with all the pots, pans, serviceware, plates & cutlery that you would need. Stacked washer/dryer in the hall closet was great with the kids (and those of us who spill on our shirts ...). The layout worked well for us, with the separate master suite and the two other bedrooms with adjacent bathroom. The bathroom is a bit dated, but very functional. We did use the den for the 4 year old's bedroom. Only issue was the TV noise bothering him as he was going to sleep (the two spaces are adjacent with folding doors), so we remedied that by taking the wine outside and enjoying a peaceful (sans kids) sunset! There are lots of games, movies, magazines, books, etc., and DeAnne put together a great "tourist" folder with tasting room coupons, maps, etc.
Fault Line Chardonnay is delicious. We managed to enjoy a bottle or two ....! Check-in & check-out went smoothly. Plenty of parking (we had 3 cars). Great location -- you seem so remote and far away, yet it was 10 - 15 min into Santa Rosa, and about 20 min to Sonoma. This is the third house in Sonoma that we've rented, and it was by far our favorite because of the view, the amenities and the solitude. We'd return in a heartbeat!!
We stayed at the house at Black Knight Vineyard this past weekend and couldn't have asked for a better experience. Nothing could top having my morning cup of coffee while watching the llama and sheep up the hill with the vineyard view in every direction and the sounds of birds everywhere. The hot tub was great and the beds were super comfy. And to top it all off DeAnne & Mitch with their daughter and dogs were superb hosts. I think we may have to go back again on our next wine country adventure.
Over 300 wineries are at your reach from this central location. Every direction affords a different, yet exciting adventure in wine country from this convenient location.
|Rate Period
|Weekend Night
Early Summer
May 31 2016 - Aug 31 2016
3 night minimum stay
|Notes: Rates are based on 4 guests; add $50 per night, per additional guest
Labor Day Weekend
Sep 1 2016 - Sep 6 2016
3 night minimum stay
Late Summer
Sep 7 2016 - Sep 30 2016
3 night minimum stay
|Notes: Rates are based on 4 guests; add $50 per night, per additional guest
Harvest Special
Oct 1 2016 - Nov 7 2016
3 night minimum stay
|Notes: Rates are based on 4 guests; add $30 per night, per additional guest
Nov 22 2016 - Nov 27 2016
3 night minimum stay
|Notes: Rates are based on 4 guests; add $55 per night, per additional guest
Winter Holidays
Dec 21 2016 - Jan 3 2017
3 night minimum stay
|Notes: Rates are based on 4 guests; add $55 per night, per additional guest
My Standard Rate
2 night minimum stay
|Notes: Rates are based on 4 guests; add $25 per night, per additional guest
|Pet Fee
|Refundable damage deposit
|Cleaning Fee
|$150 + Tax
|Tax Rate
Cancellation over 30 days before check-in get 90% refund
Cancellation under 30 days before check-in get 25% refund plus any amounts we are able to re-rent.
Cancellation under 7 days before check-in get 10% refund.


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05 November 2013 at 11:42 PM
Christina Aguilera: 'Say Something' on 'The Voice' - Watch Now!
About this photo set: Christina Aguilera rocks a black beanie while performing on The Voice for the second night in a row on Tuesday (November 5) in Universal City, Calif. The 32-year-old… Read More Here
Photo #: 2986790
Posted to Christina Aguilera, The Voice
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