text:
Choose the period
Today, my wife brought my 5-year-old daughter to visit me at the office. My boss has a speech impediment, and when she heard it, she exclaimed, "Hey my daddy can sound just like you! Show him daddy! Show him!" FML
by Anonymous / 01/12/2013 at 3:14am / United States (Texas) / Kids
Today, my husband and I finally agreed on something: marriage counseling. FML
by Anonymous / 01/12/2013 at 10:28am / Australia (New South Wales) / Love
Today, while giving my girlfriend a back-rub, she moaned and commented, "If only you could fuck this well." FML
by Anonymous / 01/12/2013 at 12:57pm / Norway (Rogaland) / Love
Today, my dad was helping me move my stuff out. I'd asked my boyfriend to deal with my sex toys and lingerie, but still my dad showed up later at my new place, handed me a box full of them all, and simply said, "I don't want to know." FML
by nean83 / 01/12/2013 at 12:11am / United States (California) / Intimacy
Today, I opened the door to go out for groceries. Lying on my doorstep was a pile of poop. A piece of paper was taped to the ground beside it that read, "Do it again and you'll get more than dog shit." I don't have the slightest clue who I pissed off, or how. FML
by fucking mafia or what?? / 01/12/2013 at 5:02pm / United States (Ohio) / Miscellaneous
Today, I found out that my sleep-walking is so bad that I regularly text my friend while I sleep. I have no idea how many times this has happened. FML
by I'm screwed / 01/12/2013 at 8:30pm / Canada (Alberta) / Health
Today, after a week of intense fighting, my girlfriend of 4 years and I hung out. She told me she loved me, and I pointed out that last week she said she was going to dump me. Without missing a beat, she replied, "Only to scare you into submission." FML
by thanksbabe / 01/12/2013 at 1:32am / United States / Love
Today, I found out that my dad, thinking it was an advertisement, threw away a letter from the college I applied to. FML
by gdog10122 / 01/12/2013 at 4:52am / United States / Miscellaneous
Today, my mom made up a new game. She thinks it's hilarious to hide my brother's creepy Batman toy around the house to creep me out. This has been going on for hours and I still scream every time. FML
by poohanne / 01/12/2013 at 1:36am / United States (Louisiana) / Miscellaneous
Today, I spontaneously poured my heart out for my boyfriend, telling him how much I love and adore him. He answered by leaning in close, saying "Jolly good" in an affected accent, and burping loud and clear in my ear. FML
by Anonymous / 01/12/2013 at 3:12pm / United Kingdom (Bristol, City of) / Love
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A subspecialty certification by the Board of Internal Medicine. Practitioners focus on diseases of the lungs and airways. Pulmonologists diagnose and treat pneumonia, cancer, asthma, occupational diseases, sleep disorders, emphysema, and other complex disorders of the lungs. They evaluate lung function, examine the bronchial airways, and prescribe and monitor mechanical ventilation. Many pulmonary disease experts are also experts in critical care.View More
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subset: commoncrawl


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In This Section
Journal Forum
A Meta-Analysis of High Resolution Audio Perceptual Evaluation - June 2016
2 comments
Synthetic Reverberator - January 1960
3 comments
Sound Board: High-Resolution Audio - October 2015
4 comments
AES E-Library
Pulse-Width Modulation (PWM) Coding of Audio Signals Using Psychoacoustic Criteria
The optimization of PWM methods is essential for the evolution of integrated digital audio systems. The proposed system employs multirate analysis of the original audio wave form with parallel evaluation of its noise-masking threshold. The signal is then requantized and PWM coded so that quantization and modulation noise is kept below this threshold. An additional oversampling and noise-shaping procedure is included to minimize modulation artifacts.
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Dec 2, 2015 Comics
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The Politics of 'Passing'
We talked to some British men and women about the pressure of hiding the fact that they're transgender in order to protect their own safety, while also acknowledging the need for greater trans visibility.
Sep 30, 2014 News
Australia's Cambodian Refugees Really, Really Don't Want to Get Sent Back
Detainees on Nauru have sewn their lips together in protest.
Aug 4, 2014 Stuff
I Lost a Chunk of My Skull in Dresden
Nov 19, 2012 News
Did Israel Assassinate Hamas' Chief Peace Negotiator?
Hours after Al-Jabari had received a draft of a permanent truce agreement with Israel, he was killed.
My Hipster Friend Got Circumcised
I went along with his mum to laugh at him getting part of his dick cut off.


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Skip to Main Content
IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards,
eBooks, and eLearning courses.
Learn more about:
IEEE membership
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Testing of polymorphism in object-oriented software may require coverage of all possible bindings of receiver classes and target methods at call sites. Tools that measure this coverage need to use class analysis to compute the coverage requirements. However, traditional whole-program class analysis cannot be used when testing incomplete programs. To solve this problem, we present a general approach for adapting whole-program class analyses to operate on program fragments. Furthermore, since analysis precision is critical for coverage tools, we provide precision measurements for several analyses by determining which of the computed coverage requirements are actually feasible for a set of subject components. Our work enables the use of whole-program class analyses for testing of polymorphism in partial programs, and identifies analyses that potentially are good candidates for use in coverage tools.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


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Justin Bieber Visits Japanese Shrine, Causes Controversy, Then Apologizes
Justin Bieber is no stranger to committing cultural gaffes, and we're not talking about his recent drama in Miami.
Justin Bieber is no stranger to committing cultural gaffes, and we're not talking about his recent drama in Miami.
Selena Gomez seems to be going through some kind of social media cleanse. MTV reports the 'Come & Get It' singer has unfollowed her on-and-off boyfriend Justin Bieber and her one-time bestie Taylor Swift on Instagram and has purged her Instagram account of all snaps with Kendall and Kylie Jenner, despite the fact that the threesome were all spotted looking super close at Coachella. What gives?
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The White House has addressed the petition to deport Justin Bieber back to Canada. Their response?
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Justin Bieber and Selena Gomez have continued to fan the flame in their on-and-off again relationship. The seemingly on-again couple were reportedly spotted together at Coachella, where the Biebs shocked fans with a surprise performance with Chance the Rapper on Sunday and Gomez hung out with pals Kendall and Kylie Jenner.
To prevent Justin Bieber and his goons from physically assaulting or hitting his peers, a paparazzo wants some sort of fine to hit The Biebs where it hurts most -- in his wallet.
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Twitter just launched an awesome new first tweets tool that allows users to see their own (and others') first tweets without having to annoyingly scroll back through their timeline. Of course, as soon as we saw this we just had to go back and look at our favorite celebs' inaugural tweets (it's a tough life here at PopCrush!). Take a look at Taylor Swift, Justin Bieber, Selena Gomez, Miley Cyrus and many more of our favorite stars' first stabs at Twitter.


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- Miss Florida 2017 stripped of crown days after win - US Weekly
- Lindsay Lohan steps out amid relationship drama - TMZ
- Was Taylor Swift snubbed by the VMAs? - Gossip Cop
- Rachel Platten sings "Fight Song" with lots of stars - Just Jared Jr
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- Fox News snubs major DNC moment - The Hollywood Reporter
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Jordan Michael Smith
Roosevelt's Lost Alliances: How Personal Politics Helped Start the Cold Warby Frank Costigliola
View All Available Formats & Editions
In the spring of 1945, as the Allied victory in Europe was approaching, the shape of the postwar world hinged on the personal politics and flawed personalities of Roosevelt, Churchill, and Stalin. Roosevelt's Lost Alliances captures this moment and shows how FDR crafted a winning coalition by overcoming the different habits, upbringings, sympathies, and past/i>
In the spring of 1945, as the Allied victory in Europe was approaching, the shape of the postwar world hinged on the personal politics and flawed personalities of Roosevelt, Churchill, and Stalin. Roosevelt's Lost Alliances captures this moment and shows how FDR crafted a winning coalition by overcoming the different habits, upbringings, sympathies, and past experiences of the three leaders. In particular, Roosevelt trained his famous charm on Stalin, lavishing respect on him, salving his insecurities, and rendering him more amenable to compromise on some matters.
Yet, even as he pursued a lasting peace, FDR was alienating his own intimate circle of advisers and becoming dangerously isolated. After his death, postwar cooperation depended on Harry Truman, who, with very different sensibilities, heeded the embittered "Soviet experts" his predecessor had kept distant. A Grand Alliance was painstakingly built and carelessly lost. The Cold War was by no means inevitable.
This landmark study brings to light key overlooked documents, such as the Yalta diary of Roosevelt's daughter Anna; the intimate letters of Roosevelt's de facto chief of staff, Missy LeHand; and the wiretap transcripts of estranged adviser Harry Hopkins. With a gripping narrative and subtle analysis, Roosevelt's Lost Alliances lays out a new approach to foreign relations history. Frank Costigliola highlights the interplay between national political interests and more contingent factors, such as the personalities of leaders and the culturally conditioned emotions forming their perceptions and driving their actions. Foreign relations flowed from personal politicsa lesson pertinent to historians, diplomats, and citizens alike.
Editorial Reviews
Jordan Michael Smith
Steven M. George
Michaela Hoenicke Moore
Honorable Mention for the 2012 Award for Best Professional/Scholarly Book in U.S. History, Association of American Publishers
"The premise that 'the Cold War was not inevitable' launches this penetrating, personality-focused exploration of its WWII roots and the late 20th century conflict whose aftershocks are still being felt today. Costigliola (Awkward Dominion) is deft in his characterization of the Big Three: Churchillboyish, flamboyant, and thrilled by armed conflict; Stalina piercingly intelligent former seminarian capable of merciless brutality for the sake of a cause; and FDRthe fulcrum, a blue-blooded trickster willing both to humor Churchill's nude effusiveness as a guest in the White House and win at Yalta the honest admiration of the insecure Stalin. With all the trappings of a dramatic HBO series (sex, intrigue, hierarchy, and global and historical resonance) Costigliola dutifully traces the reasons Roosevelt's vision of three (or four) world policemen committed to global stability failed to win out in the post-war near-term."Publishers Weekly
"Even with 60 years of writing on the Cold War's origins behind us, Roosevelt's Lost Alliances can boast of a novel thesis."Jordan Michael Smith, BostonGlobe.com
"This well-written work, based on extensive use of the private papers, personal correspondence, and published memoirs of the major participants, provides an interesting perspective on the wartime alliance and the origins of the Cold War, guaranteed to spark discussion."Choice
"In Roosevelt's Lost Alliances Costigliola deploys a finely tuned methodology to produce a learned and satisfying histoire totale of the inner workings of the Big Three wartime alliance and the reasons for its demise. He re-examines familiar material in the light of new questions and draws on previously ignored or under-utilized sources, of which the ones by women are especially important."Michaela Hoenicke Moore, H-Diplo
"As an exercise in wedge revisionism, Costigliola advances a powerful viewpoint, albeit one he might have couched with more shading and less certitude."Newark Star-Ledger
"This book offers a provocative psychological thesis on leadership and diplomacy that contributes to understanding the origins of the Cold War. It will appeal to scholars and general readers interested in the transition of the Allies from World War II to the Cold War. Highly recommended."Library Journal (starred review)
"Every so often appears a new publication that demonstrates the complexities of the historian's craft and reminds professionals that their scholarly pursuitsno matter how evenhanded, rational, or seemingly definitivemust ultimately land somewhere between art and science. So is the case with Frank Costigliola's engaging and thought-provoking new study of 'personal politics.'"Steven M. George, 49th Parallel
"Among its many contributions, Costigliola's impressive book reminds us that the emotional truths of the earlier Cold Warriors' positions will be forever undermined by the costs and scars of the conflict they helped to set in motion."Hannah Gurman,American Historical Review
"Costigliola's rich and incisive analysis will vastly deepen our understanding of the imponderables surrounding the perhaps most crucial phase of the twentieth century."Klaus Schwabe, Diplomatic History
"Costigliola's is a brave thesis, premised upon many years of fine scholarship, that will enrich our understanding of this crucial period of history. It will provoke much debate and deserves to be widely read."Alan P. Dobson, Historian
"Roosevelt's Lost Alliances is an important and well-written book. Not because it recounts familiar events, but because it is able to examine the main figures from a new perspective and, by doing so, can demonstrate how important personal views, cultural differences, and mutual misunderstanding were in the onset of the Cold War."Eszterházy Károly College, Hungarian Journal of English and American Studies
"Costigliola's insistence on exploring the private, human sides of public policy yields dividends. Utilising a wide range of new or underexploited archives, he brings out the personalities of the wartime Big Three."David Reynolds, Diplomacy & Statecraft
"Costigliola seeks to render a new, more Roosevelt-friendly judgment. Even those historians who will doubtless quibble with, or challenge, his conclusions will still find an enormous amount to enjoy and to stimulate them in this important book."Steven Casey, War in History
"This is a great read of war and politics at the very pinnacle of the Allied leadership pyramid that is both educational and surprising, engagingly crafted and well presented."Blaine Taylor, Military Advisor
Product Details
- 9780691157924
- Publisher:
- Princeton University Press
- Publication date:
- 02/24/2013
- Pages:
- 544
- Sales rank:
- 1,229,499
- Product dimensions:
- 9.10(w) x 6.00(h) x 1.30(d)
Meet the Author
Frank Costigliola is professor of history at the University of Connecticut and former president of the Society for Historians of American Foreign Relations. He is the author of France and the United States and Awkward Dominion.
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This is the bulletin board I decided to do in the main foyer for Spring. I got the idea from this great bulletin boarding website that has sample boards (http://www.boardsgalore.com/). Of course, I tweaked it and made it my own, but I have to give credit to her for the main idea, and you can get lots of other ideas there as well!
I cut my letters out of white cardstock with the Cricut machine using the alphalicious font. The first letter of each word is 10", and the rest of the letters are 9". After putting it together, I think I should have gone a little bit smaller with the letters because I didn't have much room for my sun.
The sunflowers on the side are the kind you can buy in the fake flower department of any store, like Wal-mart or Hobby Lobby. I used the border as my main support for these (stuffed them into it and stapled the border well), but I also put a couple of supporting stapling directly onto the flowers. However these staples alone would not have held the flowers on without the border's support.
Or click the original image I used below to then save or download the bag I used. Then you will have to crop the image and add text:
Or click this image below, then right click to save or download, crop it after you choose the sign you want to use, and then add the text yourself:
Here is the image that I printed, laminated, and cut out for the grapes:
Or here is the original picture that I used (Again, just download it, pull it up in something like Publisher, add a textbox to write on it, then print it off and cut it out):
Happy Bulletin Boarding for Spring!! Email me if you want me to just send you my Publisher files that I used (firstname.lastname@example.com)!


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Colorado Blues Connection Message Board › New Meetup: Let's meetup 8pm Saturday night at the Mercury Cafe Dance Hall f
|Noah N.
user 14260078
Denver, CO
Announcing a new Meetup for Colorado Blues Connection!
What: Let's meetup 8pm Saturday night at the Mercury Cafe Dance Hall for Johnny Long
When: Saturday, April 2, 2011 8:00 PM
Where: Mercury Cafe
The Mercury Cafe, 2199 California St. Denver, CO
Denver, CO 80205
Why: You get $5 off at the door if you tell them Rachael or JP sent you to enjoy this Kansas City Blues master - we expect Blues and Tango dancers, but everyone is invited to join in just for good old-fashioned Blues shakin' however the music moves you
Check it out!
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


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Bypass the box office line at many theaters with guaranteed advance tickets. If something comes up, you can return or exchange them up until the posted showtime.
Earn rewards points from our partners, including AMC Stubs, Regal Crown Club and more.
Save your favorite theaters and movies to experience a customized Fandango just for you.
Get the VIP treatment, free screenings, digital downloads, discounts and more.
Towering American character actor Charles Napier has the distinction of being one of the few actors to transcend a career start in "nudies" and sustain a successful mainstream career. Napier, clothed and otherwise, was first seen in such Russ Meyer gropey-feeley epics as Cherry, Harry and Raquel (1969) and Beyond the Valley of the Dolls (1970). Graduating from this exuberant tawdriness, Napier...


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Girls' Danshuz Value Tapper Shoes keep her style simple and her feet comfortable. These dance shoes have a cushioned insole with padded sock liner for comfort. Their soft leather-like upper with lace front design offers a clean look. These tap dance shoes have non-skid tread on the toe and Star Tone toe and heel taps for good sound. Available in standard sizes.
Sizing: Kids (4-16)
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Man made materials,
Insole Material: Man made materials
Lining Material: Textile, Man made materials
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Closure Style: Hole lacing
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More from the Fed: Treasury purchases will "initially" be $45B/month, suggesting the Committee has little compunction about raising the amount. "The committee expects that a highly accommodative stance ... will remain appropriate for a considerable time after the asset purchase program ends and the economic recovery strengthens." Bernanke's great experiment continues. Lacker dissents. Press conference at 2:15 ET.
More from the Fed: Treasury purchases will "initially" be $45B/month, suggesting the Committee...
ETF Hub
ETF Screener: Search and filter by asset class, strategy, theme, performance, yield, and much more
ETF Performance: View ETF performance across key asset classes and investing themes
ETF Investing Guide: Learn how to build and manage a well-diversified, low cost ETF portfolio
ETF Selector: An explanation of how to select and use ETFs


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2 Reviews
Wowser, put this on a silver salmon fillet and it is absolutely great. Thank to Leferro and to Grandpa.
Both my husband and I really enjoyed this. And I am not really a big salmon fan! I cut the butter to two tablespoons and only used two tablespoons of brown sugar. Those amounts worked great for us. The cooking instructions were not very complete. I cooked the salmon for 30 minutes at 350 degrees. Delicious. Your grandpa had the right idea!


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Showing posts in the category of Honda
Honda Creates Electric Motor Without Using Precious, In-Demand Metals
Honda has developed a new electric motor for its hybrid models that unlike others on the market, d...Read more
KBB Puts Six Budget-Friendly Compact SUVs To The Test
Compact SUVs are much more popular than luxury ones , so Kelly Blue Book got a Ford Escape, Mazda C...Read more
Honda Audit Reveals Manipulated Airbag Test Data
According to an ongoing Honda audit, Takata engineers have been found responsible for routinely ma...Read more
First Drive: 2017 Honda Accord Hybrid Is Low Fat With Most Of The Taste
A hybrid Accord sounds like the most logical new model introduction ever.Read more
Honda Kicks Off Musical Themed Summer Ad Campaign
Honda is getting ready to celebrate their annual Summer Clearance Event with the help of six new mu...Read more
Honda CR-Z 1.5 Gets 'Final Edition' Spec In The Philippines
Honda Cars Philippines has started its countdown for the new CR-Z IMA Final Edition, with customer...Read more
Michel Vaillant Inspired Honda Art Car Debuts On The Track This Weekend
After it won the fans' hearts at the 2016 Goodwood Festival of Speed, where it was voted as the...Read more
Video: Clarion's Supercharged Acura NSX Is Closer To Perfection Than Ever
This is a 230,000-mile 1991 Acura NSX and it very well could be one of the most desirable NSXs ou...Read more
Honda Launches Stylish Civic RS Turbo Modulo In The Philippines
Honda has just rolled out a special variant of the Civic dubbed the RS Turbo Modulo exclusively fo...Read more
Honda NSX To Spawn More Models, Including Type-R And Pure EV
Honda plans no less than five different versions of the hybrid NSX according to the model's project...Read more
Honda Considering Formula E Entry, But Not Just Yet
Honda could be the next automaker to join the FIA Formula E Championship. At the Austrian Grand Pri...Read more
Honda Bringing Upgraded Engine To British GP
As the McLaren F1 team continues to improve , its engine supplier, Honda, has confirmed that it...Read more
Fernando Alonso & Stoffel Vandoorne Demonstrate Honda NSX At Estoril [w/Video]
Work at a bar? Get free drinks. A clothing store? Employee discounts. Race for an F1 team? Drive th...Read more
Future Ariel Atom To Get Hybrid Honda Power, Autonomous Luxury Model Also Planned
The British lightweight track weapon could incorporate hybrid technology from the Honda NSX in fut...Read more
Honda Says Other F1 Teams Not Interested In Their Engine
While Honda would benefit from having another Formula 1 team use their engines aside from Mclaren ,...Read more
Five Hondas, Two Acuras Recalled Due To Takata Airbag Inflators
Defective Takata airbag inflators have made Honda and Acura expand their safety campaign to severa...Read more
Honda NSX Detailed In Fresh Gallery [82 Images]
Honda has released a new image gallery with the NSX, as the supercar is getting ready to commence d...Read more
Honda To Pull The Plug On The CR-Z In North America
Honda's compact hybrid coupe , the CR-Z, has never really caught on and now, more than six year...Read more
Place Your Bets: Honda Civic Type R Vs BMW M135i
This is a close battle between FWD and RWD as both of these contenders are fairly evenly matched. ...Read more
Celebrate 40 Years Of The Honda Accord With 40 Photos
The Honda Accord is 40 years old and few cars currently in production can say that; even less have...Read more
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SUMMARY: To wrap up another year of B2B marketing, weve reached out to seven marketers and industry experts to offer you six tactics based on marketing lessons learned in 2011.
Read on to find out what our expert sources said about lead generation, lead scoring and lead nurturing; inbound SEO; letting your customer tell you how to market to them; and making that personal touch truly personal.
Get the latest research on email, lead gen, and social media along with MarketingSherpa updates and promotions.
Website Optimization: How Brian Gavin Diamonds overcame 'mobilegeddon'
Read More »


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Heart Health Center
Fast Heart Rate - Credits
ByHealthwise Staff
Primary Medical ReviewerWilliam H. Blahd, Jr., MD, FACEP - Emergency Medicine
Specialist Medical ReviewerDavid Messenger, MD
H. Michael O'Connor, MD - Emergency Medicine
Current as ofMarch 12, 2014
In this article
WebMD Medical Reference from Healthwise
Last Updated: March 12, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
© 1995-2015 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Fast Heart Rate Topics
Today on WebMD
How to boost your 'good' cholesterol.
Learn the causes.
5 habits to change.
What's normal? What's not?


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(Oct. 26, 2011) -- If you think you know literary history, now is your chance to put your knowledge to the test. The UTSA Department of English will host the inaugural "Name That Author" competition at 7:30 p.m., Friday, Oct. 28 in the Business Building University Room (2.06.04) on the Main Campus.
The questions will span the entire history of English and American literature, and the competition will be divided between undergraduate and graduate students. Cash prizes totaling $2,000 will be awarded to six finalists.
"We will have six panelists at a time answering questions and competing against each other," said Steven Kellman, UTSA professor of English. "The top three will move on to the second round and the first prize winners in both categories will receive $600, then $300 for second place and $100 for third."
Kellman came up with the idea after hosting a similar event as an officer in the National Book Critics Circle at the Texas Book Festival in Austin. The competition was a success with both professional authors and audience members in attendance. Kellman hopes the competition is successful enough to become an annual event at UTSA.
"I hope people are entertained in an intellectual manner, which is appropriate in a university setting," said Kellman. "We now have a football program, so there is no reason why we can't also have academic competitions."
The $2,000 in cash prizes is provided through the endowment of Sonja Lanehart, UTSA professor and Brackenridge Endowed Chair in Literature and the Humanities.
For more information, contact Steven Kellman at 210-458-5216.
The UTSA Interactive Technology Experience Center camps are for curious youth who are interested in STEM and related topics. This week, campers will study environmental science, robotics and computer science.
UTSA Main Campus
In four sessions of this weeklong day camp for 9 to 13-year-olds, campers will participate in indoor and outdoor activities while exploring ancient technologies from around the world and the new technologies archaeologists are using to discover them.
UTSA Center for Archaeological Research, Main Campus
Campers will investigate how museums use artifacts, oral histories, and research to unravel stories about our past.
UTSA Institute of Texan Cultures
UTSA Math faculty prepare participants for success in their future math courses.
UTSA Main Campus
Staff can help campers improve their technical skills and knowledge of the game while having fun.
Tennis Courts, UTSA Main Campus
An opening reception is being held for the exhibit "Girl's Eye View" which was produced by students who documented life on San Antonio's East Side with photography, poetry and film.
UTSA Institute of Texan Cultures
Experience a very different summer camp! The UTSA East Asia Institute is teaching kids Japanese through language, culture, art, crafts, music, cooking and more. For kids age 6-12. For more details, email firstname.lastname@example.com.
Main Building (MB 1.126), Main Campus
7 to 12 year-olds will explore Mayan Culture in a three-day sessions, concluding at the Witte museum, where campers will have the chance to see the new "Maya: Hidden Worlds Revealed" exhibit.
UTSA Center for Archaeological Research, Main Campus
Other Calendars
» UTSA Events | » Academic | » Institute of Texan Cultures
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.


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Shakes or Wobbles problem
2000 Honda S2000 4 cyl Two Wheel Drive Manual 73000 miles
My car just started vibrating from the rear. It does it at all speeds but get worse as you accelerate. Is it possible that the tires went out of balance
Wednesday, November 26th, 2008 AT 11:47 PM


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Rosamond Vacation Packages
Rosamond is within easy reach of a diverse collection of Mojave's more popular attractions. The Antelope Valley Fairgrounds and the Elyze Clifford Interpretive Center are just two of the popular places to visit. Two other interesting attractions that are located nearby Rosamond are the Rancho Vista Golf Club and Blackbird Airpark.
If the weather is good get into the great outdoors and make the most of the nearby green spaces. If you're looking for a little nature check out the Mojave East Park.
If you love to play golf, head to the Camelot Golf Club. It's a perfect way to enjoy the outdoors.
Hangar Stadium, Lancaster is a great place to spend an afternoon enjoying baseball, and to see local favorites, the Lancaster JetHawks, in action. On game days follow the river of red, navy and white, to the stadium, then after the full-time hooter blows, join fans at a nearby pub, bar or cafe for a post-game drink.
When you're ready to slow down after enjoying the delights of Rosamond, check in to one of the area's numerous bed-and-breakfast, hotel and short-stay apartment options. Take your pick from the Embassy Suites Palmdale, the Oxford Inn & Suites Lancaster, or the Hilton Garden Inn Palmdale.


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text: 8 Bilingual and Immersion Programs for Westchester Preschoolers Submitted by Melissa Kagan on Wed, 07/20/2016 - 4:00pm A growing number of parents are enrolling their preschoolers in foreign-language programs in an effort to expose them to a second language early on. Multi-lingualism and immersion programs may offer cognitive advantages to kids, and many preschools are incorporating second languages into their curriculum to accommodate the heightened interest. We've rounded up a list of preschools in Westchester that teach a second language. If you're searching for more preschool information, be sure to take a look at our specialized Preschool Guide. Read more.


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January sentencing set for mother who drowned newborn
Published: Saturday, December 3, 2005 at 3:30 a.m.
Last Modified: Friday, December 2, 2005 at 11:00 p.m.
MOBILE | A jury convicted a Mobile woman on the lesser charge of manslaughter Friday in the toilet drowning of her newborn.
Mobile County Circuit Judge Rick Stout set a Jan. 26 sentencing date for Tina Machelle Graham, 39, who has three other children.
Her newborn girl drowned in a toilet inside Grahams home on Feb. 14, 2004, authorities said. The babys body was recovered from a closet.
Graham was on trial for murder, but the jury found her guilty of the lesser charge, which could bring two to 20 years in prison.
Forensic witnesses said the child was alive when born and died by drowning.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
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text: Apology Video: Scouts Canada apologizes to victims of abuse Add to ... The Globe and Mail Published Thursday, Dec. 08, 2011 7:23PM EST Last updated Thursday, Dec. 08, 2011 7:23PM EST Scouts Canada is saying sorry for alleged sexual abuse by volunteer leaders. Chief Commissioner Steve Kent made the apology in a solemn six-minute video posted to YouTube Thursday. Watch More Video: Trump: Clinton should have congratulated me for making history Funeral for Ottawa man who died after police altercation He-said-she-said: Contrasting Trump and Clinton's convention speeches Bad boy 'Justin' beaver terrorizes B.C. town Two San Diego police shot, one killed 'No Donald, you don't': Watch the highlights from Hillary Clinton's convention speech Chelsea Clinton on her mother - 'my role model' - and Triceratops Hillary Clinton accepts the Democratic nomination with 'humility, determination' 'I will gladly lend you my copy': Father of fallen Muslim soldier offers Trump his Constitution Clinton has 'got a friend' in Carole King Fixing payroll debacle will cost up to $20 million: Official 'He destroyed our family': Sammy Yatim's mother says her anger hasn't dissipated Const. Forcillo sentenced to six years in shooting death of Sammy Yatim Sarandon, Glover, Woodley protest DNC snub Three Kentucky inmates walk out open jail door; one still missing Pope Francis tumbles at World Youth Day ceremony Video: Obama asks America to 'reject cynicism and reject fear' Biden says Trump's stated concern for middle class is 'bunch of malarkey' 'Russia, if you're listening': Trump calls on hackers to find Clinton's missing emails Trump denies involvement in email hack, impersonates Jon Lovitz Comments AA Follow us on Twitter: @globeandmail


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|Home | About | Journals | Submit | Contact Us | Français
Nonmelanoma skin cancer (NMSC) is the most common human cancer, with an incidence of more than 1.2 million per year in the U.S.A. The risk for the development of NMSCs increases by approximately 10–250 fold in chronically immune suppressed organ transplant recipients (OTRs). Solar UVB is the most common etiologic factor in the development of this neoplasm, both in immune competent and immune suppressed populations. This review provides a description of NMSC in OTRs. It also provides an account of the various immunologic and non-immune-dependent mechanisms involved in the pathogenesis and progression of NMSCs in OTRs. Finally, this review addresses possible strategies for the prevention of this cancer, particularly focusing on the aspects that may be incorporated to prevent negative effects of chemopreventive chemicals on graft survival.
Nonmelanoma skin cancer (NMSC), the most common human cancer, has an incidence of more than 1.2 million per year in the U.S.A.. Moreover, its risk in immune suppressed populations increases by 10–250 fold. It is believed that immunosuppressive drugs create a conducive microenvironment that facilitates the unrestricted growth of cancer-initiated cells. It is also believed that, similar to immune competent individuals, the major etiologic factor for NMSC remains ultraviolet B radiation (UVB) in organ transplant recipients (OTRs). In immune competent individuals, factors such as skin color, cumulative UVB exposure, and genetic background influence tumor growth. In addition to these factors, tumor growth and aggressiveness depend on the level, type, and duration of immunosuppressive therapy, age at transplantation and type of transplanted organ in OTRs. Impairment of the body's immune functions following chronic use of immunosuppressive drugs leads to an inability to eradicate cells with precancerous changes. There are also direct carcinogenic effects of these agents on cancer-initiated cells. Skin cancer is a significant cause of morbidity and discomfort to OTRs who already suffer from numerous serious medical issues. Therefore, prevention of skin cancer in this high risk population is a major priority in these patients. Some of the successful chemopreventive agents tested in human skin include retinoids, cyclooxygenase inhibitors, and ornithine decarboxylase inhibitor, difluoromethylornithine (DFMO). It remains to be determined whether these agents can successfully be employed in OTRs to block skin neoplasms without damaging the graft organ. This review addresses some of these issues.
The lifetime risk for skin cancer development in the US is estimated to be 1 in 5 and greatly exceeds the incidence of all other neoplasms together [1,2]. About 1/3 of all human cancers occur in skin and more than 1.2 million new cases of non-melanoma skin cancer (NMSC) including both squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are reported annually in the US alone [1]. In addition to UVB, fair skin and age are also key risk determinants for NMSCs. Interestingly, the risk for NMSCs is further augmented in chronically immune-suppressed organ transplant recipients (OTRs).
In 2008 in the United States, about 200,000 people were living with a functioning transplanted organ or graft, another 100,000 were on the active national transplant waiting list, and 27,961 solid organ transplants were performed (See Table 1). Of all cancers that arise in OTRs, 95% are skin cancers [3]. However, the incidence of malignant melanoma, Kaposi's sarcoma, Merkel Cell tumors, cutaneous T-cell lymphoma, cutaneous B-cell lymphoma, natural killer cell lymphoma, angiosarcoma, malignant fibrous histocytoma, leiomyosarcoma, and sebaceous carcinoma, which rarely occur in the general population, is enhanced in OTRs. Kidneys are the most frequently transplanted solid organ and, therefore, the majority of skin cancers in OTRs occur in this population (See Table 1). The risk of SCC in immunosuppressed patients is between 65- and 250-fold higher than in the general population, and the risk of BCC is 10-fold greater [4]. Analyses of Medicare claims data and the Organ Procurement and Transplant Network/United Network of Organ Sharing database have shown that the incidence of NMSC in chronically immune suppressed OTRs increases from 2.25% at 1 year to 4.95% at 2 years, and 7.43% at 3 years, and then further increases to 10–27% and 40–60% after 10 and 20 years of immune suppression respectively [5]. These patients develop NMSCs at a relatively young age with an increased risk of local recurrence, regional and distant metastasis and significant morbidity and mortality [6]. SCCs metastasize in 5–8% of transplant recipients [4]. Compared to an immune-competent population in which the ratio of BCCs/SCCs is ~3:1, the immunosuppressed population develops these neoplasms in the inverse ratio of 1:4 [7]. In addition to the factors that determine risk of NMSCs in the general population, the level, type, and duration of immunosuppressive therapy, age at transplantation and type of transplanted organ also determine the risk of skin cancer in OTRs. OTR patients at low latitudes develop a much higher incidence of skin cancer than those living at higher latitudes. Thus, in Australia 45% of OTR patients develop a NMSC within 10 years of transplantation, whereas in countries with a temperate climate (e.g. Holland, England, and Italy) the incidence is only 10–15% (Clinuvel) [8].
In transplant recipients, immunosuppressive drugs severely impair the body's immune functions. Among the cell types affected are T lymphocytes, natural killer cells as well as dendritic and other antigen presenting cells. The end result is disrupted immune surveillance. As a result, a microenvironment is created that is conducive to unrestricted tumor growth. Tumors developing in chronically immune suppressed OTRs result from either transfer of neoplastic cells from donor organs or reoccurrence of primary tumors. In addition, this population is at greater risk for developing virus-induced neoplasms. This is evidenced by the fact that the increased incidence of Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorders occurring in OTRs decreases following the withdrawal or tapering of immunosuppression. Similar results have been reported in transplant recipients infected with human herpes virus-8 (HHV-8) that develop Kaposi's sarcoma [9,10].
Skin cancers associated with human papilIoma virus (HPV) infections also regress following reduction in immunosuppression. In OTRs the pathogenesis of virus infection-induced skin cancer is also significantly enhanced. For example, HPV can be found in up to 90% of cutaneous SCCs in OTRs compared to 11–32% in immunocompetent individuals [11]. In addition, cutaneous SCCs and HPV-induced warts usually co-localize in this population suggesting that these warts may progress into skin cancers. Cutaneous HPV types, the E6 oncoproteins, target Bak for proteolytic degradation. E6 protein of cutaneous HPV1 and HPV8 can also bind to XRCC1 protein which is required for the repair of single strand DNA breaks thereby impairing the efficiency of their repair. UVB-induced thymine dimers repair is also affected by E6 protein of the beta HPV5 [12]. Interestingly, certain HPVs such as the wart-associated HPV77 utilize the UVB-induced SOS-response program of the host cell to increase their own transcription activity [13]. In addition, oncogenic viruses may indirectly augment the carcinogenic response in OTRs, the description of which is beyond the scope of this review [14].
In both immune-competent and immune-suppressed populations, UVB induces photo-products in DNA that include cyclobutane dimers and (6–4) photoproducts. These lesions are potentially mutagenic and if not repaired, can lead to C to T and CC to TT transition mutations, also known as UVB "signature" mutations. These mutations occur frequently in tumor suppressor genes, oncogenes and/or other genes involved in the pathogenesis of these UV-induced skin cancers. Treatment with immunosuppressive drugs enhances the number of microscopic clones of cells overexpressing mutant p53 in renal transplant recipients [15, 16]. These p53 patches are considered precursor cells for the induction of actinic keratosis and SCCs, and were found to be immunogenic in murine skin.
NMSCs behave more aggressively in chronically immunosuppressed individuals. The exact mechanism(s) by which this aggressive phenotype is achieved remains elusive. It is believed that immunosuppressive medications lead to impaired immune surveillance and failure to eradicate cells with precancerous changes. In addition, direct carcinogenic effects of these agents may also contribute to some of these effects.
Cyclosporine A (CsA) is the common immunosuppressive drug used in OTRs to prevent rejection of the transplanted organ. Additionally, CsA is also employed in the treatment of multiple diseases such as nephrotic syndrome, Crohn's disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis, psoriasis and dermatomyositis. The risk of skin cancers in patients receiving prolonged treatment with CsA is increased. For example, patients receiving CsA-azathioprine-prednisone were found to have a 3–4.2-fold increased risk of NMSC compared to patients receiving azathioprine-prednisone alone [17,18]. In a 66 month follow-up, 60 of 231 transplant (26%) recipients receiving CsA developed cancers, 66% of which were skin cancers [19]. In a study of 488 OTRs, 10.4% receiving CsA developed a first NMSC [20]. These data together clearly indicate that CsA administration enhances skin cancer risk in humans.
CsA acts by binding to a cytoplasmic protein, cyclophilin (immunophilin) in lymphocytes, particularly T-lymphocytes. The CsA-cyclophylin complex inhibits calcineurin, which dephosphorylates the transcription factor, nuclear factor of activated T-cells (NFAT), promoting its translocation from the cytoplasm to the nucleus. NFAT is required for the transcription of interleukin-2 (IL-2). Thus inhibition of calcineurin signaling blocks IL-2 production leading to reduced numbers of effector T-cells. In addition, blockade of NFAT signaling may also alter tumorigenesis response as discussed in detail in the proceeding section [21].
Recently, we showed that A431 SCC xenograft tumors grown in nude mice develop much faster and become much larger in size following treatment with CsA. We also showed that CsA-induced alterations are not reversible following cessation of CsA treatment and retain the inhibition of calcineurin signaling. CsA-treated tumors manifested enhanced cellular proliferation and tumor vascularity associated with high expression of vascular endothelial growth factor (VEGF). These tumors also showed increased epithelial-mesenchymal transition (EMT) and associated markers, fibronectin, α-SMA, vimentin, N-cadherin, MMP-9/−2, snail, slug, and twist with a concomitant decrease in the epithelial polarity marker E-cadherin. CsA increased transforming growth factor beta-1 (TGFβ1) expression with a concomitant increase in cell migration/invasion and a decrease in apoptosis [22]. In addition, CsA alters mitochondria-dependent cellular functions and blocks the mitochondrial permeability pore (MPP) opening, which modifies the ability of cells to undergo apoptotic cell death. We also showed that CsA-pretreated skin carcinoma cells do not respond to agents that induce apoptosis by inhibiting mitochondrial cytochrome c release, a potent pro-apoptotic stimulation factor [23].
As early as 1975, Koranda et al [24] demonstrated that treatment of hairless mice with immunosuppressive agents accelerated UVB-induced skin cancer development. They showed that 57% of immune suppressed animals developed SCCs by 139 days whereas only 18% of immune-competent mice developed these tumors after 180 days. However, no metastases were observed in the animals on chronic immune suppression regimens. Similarly, Nelson et al [25] showed that subcutaneous administration of CsA as well as azathioprine enhanced UVB-induced skin cancer development in murine models. In another study, azathioprine, prednisolone, cyclophosphamide, and CsA were found to enhance UVB-induced carcinogenesis [26]. However unlike other immunosuppressive drugs, cyclophosphamide did not enhance malignant progression,. Servilla et al [27] confirmed that CsA augments the growth of UVB-induced transplanted tumors. However, contrary to earlier observations topical CsA inhibited phorbol ester-induced cutaneous tumor promotion [28]. In further studies, these results were confirmed by Yokota et al who showed that topically administered CsA behaved differently than parenterally administered CsA with respect to its effects on tumor development [29]. Interestingly, rapamycin (sirolimus) administration while protecting against allograft rejection, also diminished tumor growth in various immune suppressed murine models [30].
Recently, Wulff et al re-investigated the effects of immunosuppressive drugs on UVB-induced skin carcinogenesis in SKH-1 hairless mice [31]. Similar to earlier reports, they also observed an enhanced tumor progression following CsA administration in UVB-irradiated animals. Moreover, tumor size in CsA-treated animals was much larger than in control animals. Rapamycin when co-administered with CsA, significantly decreased multiplicity, size and progression of benign lesions to SCCs. The augmented tumor growth in chronically immune suppressed animals was demonstrated to be related to enhanced inflammation and tumor angiogenesis [32]. Their study also showed that degree of enhancement in skin carcinogenesis by immunosuppressive agents is variable and depends upon the nature of the administered immunosuppressive drug.
O'Donovan et al showed that the immunosuppressive drug, azathioprine acts through a distinct mechanism to augment tumor growth. Exposure of azathioprine-treated patients to UVA generated mutagenic adducts detectable in their skin. There was a direct correlation between adducts and the enhanced occurrence of skin cancer in these patients [33]. Dworkin et al proposed that enhanced chromosomal aberrations in UVB-induced tumorigenesis result from chronic immune suppression [34]. These studies also demonstrated the distinctive mechanisms associated with specific immunosuppressive drugs. Thus, tacrolimus treatment augments skin carcinogenesis via chromosomal aberrations whereas CsA targets an entirely different pathway. In addition, alterations in telomere length and telomerase activity were found to influence the incidence of both BCCs and SCCs in immune suppressed populations [35,36].
Vogt et al showed that treatment of Ptch+/− mice with immunosuppressive drugs does not significantly alter their lifespan. However, they noted a 2.5 fold increase in BCC burden in CsA and prednisolone immunosuppressed animals exposed to ionizing radiation derived from a cesium-137 source [37]. Consistent with the notion that CsA enhances TGFβ1 signaling, elevated P-Smad2 levels were found to be associated with the tumors excised from OTRs [38].
The gross immunologic mechanisms related to enhancement of skin carcinogenesis in immune suppressed populations may not differ significantly with the type of immunosuppressive agent used. However, immune-independent mechanisms which usually represent the direct effects of immunosuppressive agents on cancer cells may be agent specific. Recently Wu et al [21] reported that genetic and pharmacological suppression of calcineurin/NFAT function by CsA promotes tumor development in murine skin and in xenografts in immune compromised animals. Calcineurin/NFAT inhibition counteracts p53-dependent cancer cell senescence thereby enhancing its tumorigenic potential. These authors found that ATF3, which is a member of the AP1 family, is selectively induced by calcineurin/NFAT inhibition in human and murine tumors. ATF3 suppresses p53-dependent senescence and tumorigenic potential [21]. CsA enhances AKT activation by reducing the expression of PTEN. In addition, it has been shown that CsA-mediated PTEN downregulation occurs at the transcriptional level and is dependent on epidermal growth factor [39].
Skin cancer is a significant cause of morbidity and discomfort to OTRs who already suffer from numerous serious medical issues [4–8]. Therefore, prevention of skin cancer in this high risk population is a very important issue. Chemoprevention strategies are focused on reducing and delaying the development of skin cancer in these patients. Besides sunscreens and educational aspects of skin cancer prevention, the management of cutaneous neoplasms through the use of relatively non-toxic and highly tolerable chemical agents is a primary goal of skin cancer chemoprevention programs [40, 41]. In immune-competent populations, a number of agents have been found to be effective in reducing the risk of skin cancer [42]. Many of these agents are derived from dietary and herbal constituents while others are synthetic chemical compounds targeting specific proteins. Some of the synthetic agents successfully tested in humans include retinoids, cyclooxygenase inhibitors, and the ornithine decarboxylase inhibitor, difluoromethylornithine (DFMO). However, the major issue with the use of chemicals proven effective in immune-competent populations is their potential deleterious effects on graft survival and function which needs to be evaluated before they can be recommended for trial in OTRs [43].
Retinoids have been employed in a number of human trials to block skin carcinogenesis in transplant patients [43,44]. Interestingly, these studies report a reduction in malignant and pre-malignant lesions in this population. These studies also describe an increased benefit of systemic retinoids in patient populations with a previous history of skin cancer. In this regard, acitretin proved more effective than other retinoids tested. The side effects of this treatment are observed only in a minority of patients and include cheilitis, dry skin, hair loss, elevated cholesterol and triglycerides, and thrombocytopenia. These agents are, in general, well tolerated in terms of their effects on the graft. Although graft failure/dysfunction was reported in several cases, it was not considered due to retinoid therapy. However, the major concern with the use of retinoids remains the rebound reoccurrence of skin neoplasms which is often found following discontinuation of the drug. The exact mechanism by which these agents act to block skin cancer development remains largely unknown, but retinoids are known to exert physiological effects by binding to specific nuclear receptors which belong to a super family that includes receptors for glucocorticosteroids, thyroid hormone, vitamin D, and peroxisome proliferator-activators. The two classes of retinoid nuclear receptors, retinoid nuclear receptors (RARs) and retinoid X receptors (RXRs), are encoded by distinct genes that form multiple heterodimers or homodimers and, in turn, activate ligand-dependent transcription factors for genes containing a retinoic acid response element (RARE). Interestingly, about 500 genes have been found to contain retinoid regulatory elements [43]. It remains to be determined whether this mechanism also operates in OTRs.
DFMO is an irreversible suicidal inhibitor of ornithine decarboxylase, a rate limiting enzyme in the polyamine biosynthetic pathway. Polyamines are important for cell growth and proliferation. DFMO has been shown to be effective in reducing actinic keratosis and BCCs in immune-competent human populations [45]. We and others have shown that ornithine decarboxylase is an important molecular target for the chemoprevention of BCCs and SCCs in experimental animals [46,47]. Carbone et al [48] conducted a Phase 1 trial in 18 OTRs randomized to 0.5 or 1.0 grams of DFMO or placebo in a study designed to investigate the short term toxicity of this agent over a period of 28 days. In this trial they also investigated the effects of DFMO on skin polyamine levels and TPA-induced ODC activity. These experiments suggested that DFMO might be an effective chemopreventive agent in skin cancer. Although a Phase 2b clinical trial of DFMO in OTRs is listed in the Clinical Trials Registry, the results of this trial have not yet been published.
In another study, capecitabine, which is a pro-drug for 5-fluorouracil (5-FU), was tested at low doses as a chemopreventive agent in solid transplant recipients. In this study, the cumulative incidence of SCCs, BCCs and actinic keratoses was significantly reduced with manageable toxicity [49].
There has been considerable support for the use of the m-TOR inhibitor sirolimus based on reports of its ability to reduce skin cancer risk in OTRs. These results were initially based on analysis of retrospective studies indicating that changing the immunosuppressive regimen to a sirolimus-based regimen may reduce the incidence of NMSC. In an assessor-blinded prospective, randomized, controlled trial, switching to sirolimus treatment in renal transplant recipients was assessed for its ability to block NMSCs [50]. This trial demonstrated the superiority of sirolimus therapy in terms of inhibiting the progression of skin cancers as well as promoting the regression of pre-existing premalignant lesions. This study also showed that rapamycin treatment delayed development of premalignancies and reduced the incidence of new NMSCs. Another proliferation signal inhibitor and an analog of sirolimus, everolimus was also found to be a potent anti-neoplastic and immunosuppressive agent [51]. Despite being highly attractive as cancer chemopreventive agents, chronic use of m-TOR inhibitors is associated with a number of side effects which often require discontinuation of the treatment. Among these, dyslipidemia is a common manifestation in these patients and requires treatment with lipid lowering agents. It is believed that m-TOR inhibitors reduce catabolism of apo B100 which leads to increased triglycerides and cholesterol in both experimental animals and humans. In addition, decreased lipoprotein lipase activity and increased free fatty acid levels may be contributing factors. Maluf et al [52] suggested that a polymorphism in apo E may influence the degree of hyperlipidemia in kidney transplant patients receiving sirolimus treatment.
In an immune competent population, specific COX-2 inhibitors proved effective in reducing skin cancer risk [53]. However, the use of these agents in OTRs has potential risks particularly in terms of their negative effect on kidney graft and cardiovascular functions. This is based on the fact that the COX-2 inhibitor, celecoxib, was found to be associated with an increase in serious cardiovascular events in individuals at high risk for cardiovascular disease. However, it is conceivable that topical preparations of COX-2 inhibitors or non-specific COX inhibitors may be relatively risk free.
OTRs are at a high risk of skin cancer development. In this population, skin cancer is a source of high morbidity and significant mortality. In addition to various factors that are associated with increased risk of skin cancer in an immune competent population, the skin cancer risk of OTRs is dependent on factors related to the transplanted graft and to treatment protocols. The risk of cancer development increases exponentially with increasing time post transplant. Due to the lack of certainty about the deleterious effects of chemical agents on transplanted organs, the use of chemopreventive agents as an approach to managing skin cancer development has not progressed. The hope for the preventive management of skin neoplasms lies with the observations that certain types of immunosuppressants, particularly those which are mTOR inhibitors, manifest tumor growth blocking effects. Although some of these agents are not well tolerated by OTRs, their use is common in combination with other anti-graft rejection medications. Development of better TOR inhibitors holds promise for skin cancer chemoprevention. In addition, topical agents that proved effective in immune-competent populations should also be tested in OTRs.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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Napoleon BGNV40N2
BGNV40N2 See Thru Black Door Natural Vent Gas Fireplace
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Academic Experience at Northwest Vista College:
There are a lot of school programs and study groups from my perspective. I will probably always be able to find a way to be successful; whether it be from finding a study group or pushing myself.
Student Body at Northwest Vista College:
With a small class size, there are a lot of opportunities to my disposal. When it comes to asking questions there will probably always be someone there to assist me.
Academic Flexibility at Northwest Vista College:
As a first-time in college student, I can only hope that I can manage to keep up with everything, primarily school-wise.
Tuition & Financial Aid at Northwest Vista College:
I really like Northwest Vista College (NVC) because the tuition and fees are extremely affordable plus the administrators are generally happy and helpful to students.
Career Services at Northwest Vista College:
I have not yet tried applying for any organizations at school but during the spring semester i do and hopefully i will be accepted.
Student Body at Northwest Vista College:
Viasta is a very diverse school you have students coming straight out of high school and people as old as 40 trying to get a degree. I admire thoughs older people who go back to get a degree. Not many would go back but they do and it says that they want to work hard, get a better career, and do something great for themselves.
Academic Experience at Northwest Vista College:
At Northwest Vista for new comers i recommend that you get your registration done a soon as possible if not well good luck trying to find a class they fill up faster than a mintue your allowed to find your classes so be prepared. Honestly Vista needs more classes because it is rediculas how much its a struggle to find a class you need to fit with the other classes you have already chosen if they are already taken.
Tuition & Financial Aid at Northwest Vista College:
Its the best to be going to school and not have to pay out of pocket. I did it for my first semester since my finacial aid was not ready in time due to some confusing paperwork and it drilled a whole in my pocket.
Academic Flexibility at Northwest Vista College:
I do have a job but i resechedule it based upon school school is frist priority but so far its kinda been a hassle for me to figure out what i can manage.
Overall Experience at Northwest Vista College:
Classes are a good size just like a regular high school class but some of the techers assign way to much work for the course and dont really teach effectivelly. I understand that we are in the 21st century but there is such a thing as to much.
Overall Experience at Northwest Vista College:
I haven't looked into the value of a degree from northwest vista but I am using it as a stepping stone to transfer.
Tuition & Financial Aid at Northwest Vista College:
This is the least expensive college to attend and I get more than enough financial aid.
Student Body at San Antonio College:
Everyone seems apart of the school.
Overall Experience at San Antonio College:
The teachers are great, easy to make friends, and the help around the school is the best!
Overall Experience at San Antonio College:
The quality of your education is great with the right teachers.
Academic Experience at San Antonio College:
I have the sources at school just not the time to talk to people.
Academic Experience at San Antonio College:
Applying for the school was the absolute worst! they got my name, social, and school identification number wrong, i had two! but after that was fixed it was smooth sailing.
Academic Flexibility at San Antonio College:
The hours for classes meet my schedule perfectly and most teachers are great.
Campus Resources at San Antonio College:
The over all campus is great. I love the feel and vibe of the school and the proximity of my classes. It's really easy to remember where everything's at but the only downfall is no pool. Since I came from a high school where I was apart of the swim team and is my way of working out, I would of loved to have a pool to go to and exercise.
Academic Experience at San Antonio College:
I have just started, Math is hard for me but math labs are available to help
Academic Experience at San Antonio College:
Professors are the only boundary sometimes you get good professors sometimes you don't and you have to work around the work load and grading
Tuition & Financial Aid at San Antonio College:
Tuition is low and financial aid is good BUT financial aid office can be little to no help I hope they can bring better help in
Tuition & Financial Aid at Palo Alto College:
every year, the amount of my financial aid goes down, despite that there have been little changes in my economic and financial situation. the out of district tuition is MONSTROUS. getting financial aid involved several hours of walking back and forth from the bursar's office to the financial aid office, trying to find out what i needed. in order to even get the full amount of financial aid (which wasn't much) i had to take on a full time load. The financial aid office was friendly and helpful but the ladies at the bursar's office were quiet and very unemotional and unfriendly.
Student Body at Palo Alto College:
i hardly interact with anyone at school. unless you are in the same age group, then meeting someone you know is hardly likely to happen. but i do see a variety of students here from all backgrounds.
Campus Resources at Palo Alto College:
they really are great but all the funds generated for looks does not really help the academics portion.
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Movies and Musicals Saturday 18 May 2013
"Gypsy is nothing if not Broadway's own brassy, unlikely answer to 'King Lear" (Theatre critic Frank Rich)
The musical Gypsy is loosely based on the 1957 memoirs of Gypsy Rose Lee, the famous striptease artist, and focuses on her mother, Rose, whose name has become synonymous with "the ultimate show business mother." It features several hit songs from the pen of Jule Style and Stephen Sondheim including 'Some People' and 'Everything's coming up Roses". Aedín checks out three leading ladies on three different recordings of this great musical, Ethel Merman, Patti LuPone and Imelda Staunton
Classics from stage and screen for your Saturday afternoon including music from three of Nora Ephron's hit films, When Harry Met Sally, Sleepless in Seattle and Julie and Julia.
Lea Salonga is among Aedín's singers today, the Filipina soprano and actress gained fame through her roles in the musicals Miss Saigon and Les Misérables. Renowned violinist Nicola Benedetti plays the stunning main theme from Ladies in Lavender. Hit songs too from Sweet Charity and Brigadoon
A look at two film festivals - Galway and Fastnet plus lots of latest casting news!
Title: The Merry Old Land Of Oz
Performer(s): Arlen, Harold/Harburg, E.Y. Yip
Duration: 2:38
Title: If I Only Had The Nerve
Performer(s): Arlen, Harold/Harburg, E.Y. Yip
Duration: 1:22
Title: Doll On A Music Box / Truly Scrumptious
Performer(s): Sherman, Richard M. / Sherman, Robert B.
Duration: 2:39
Title: On Golden Pond
Performer(s): Grusin, Dave
Duration: 4:01
Title: New Hampshire Hornpipe (From On Golden Pond)
Performer(s): Grusin, Dave
Duration: 2:45
Title: Get Me To The Church On Time
Performer(s): Lerner, Alan Jay/Loewe, Frederick
Duration: 2:59
Title: Raiders March
Performer(s): Williams, John
Duration: 5:20
Title: The March Of Siamese Children
Performer(s): Rodgers, Richard
Duration: 3:52
Title: Unsquare Dance
Performer(s): Brubeck, Dave
Duration: 2:17
Title: The Kite Runner [2007]- Kite Shop
Performer(s): Alberto, Iglesias
Duration: 3:21
Title: Let's Go Fly A Kite (From Mary Poppins)
Performer(s): Sherman, Richard M. / Sherman, Robert B.
Duration: 2:02
Title: Hymn To The Fallen
Performer(s): John Williams
Album: Saving Private Ryan (Music from the Original Motion Picture Soundtrack)
Duration: 6:25
Title: One
Performer(s): Hamlisch, Marvin/Kleban, Edward
Duration: 5:05
Title: Shall We Dance
Performer(s): Rodgers, Richard/Hammerstein Ii, Oscar
Duration: 4:38
Title: Por Una Cabeza
Performer(s): Gardel, Carlos
Duration: 4:08
Title: Brooks Was Here
Performer(s): Newman, Thomas
Duration: 5:20
Title: Love Actually - Glasgow Love Theme
Performer(s): Armstrong, Craig
Duration: 2:22
Title: To The Opera!
Performer(s): Zimmer, Hans
Duration: 4:18
Title: It Had To Be You
Performer(s): Jones, Isham/Kahn, Gus
Duration: 3:41
Title: Stardust
Performer(s): Carmichael / Parish
Duration: 3:45
Title: Julia's Theme
Performer(s): Desplat, Alexandre
Duration: 2:28
Title: A Weekend In The Country
Performer(s): Sondheim, Stephen
Duration: 6:56
Title: Excerpt From Manhattan
Performer(s): Gershwin, George
Duration: 7:17
Title: Hello Young Lovers
Performer(s): Rodgers / Hammerstein
Duration: 3:44
Title: Out Of My Dreams
Performer(s): Rodgers, Richard/Hammerstein Ii, Oscar
Duration: 7:04
Title: Too Much Reality From As Good As It Gets
Performer(s): Zimmer, Hans
Duration: 6:18
Title: There's A Fine, Fine Line
Performer(s): Lopez, Richard/Marx, Jeff
Duration: 2:54
Title: Mahna Mahna
Performer(s): Umiliani, Piero
Duration: 2:20
Title: Siegfried Idyll
Performer(s): Wagner, Richard
Duration: 10:48
Title: My Edward And I
Performer(s): Marianelli, Dario
Duration: 4:08
Title: Awaken
Performer(s): Marianelli, Dario
Duration: 4:40
Title: Two Little Girls From Little Rock
Performer(s): Styne, Jule / Robin, Leo
Duration: 3:18
Title: I Love To Laugh
Performer(s): Sherman/Sherman
Duration: 2:59
Text '51554'
Presenter: Aedín Gormley
Producer: Eoin O'Kelly
Production Co-ordinator: Linda McGlynn


text:
Slow PunctureLast updated at 12:01AM, March 26 2016
The government is neglecting its promises to cyclists
The summer party and first anniversary of meeting her boyfriend should have made it one of her happiest days. Alex McVitty, 26, talked to her mother about what she would wear for the occasion before getting on her bike and heading off to her City law firm.
It was a clear June morning as she cycled along her usual route to work. A concrete mixer overtook her twice as she pedalled along London Wall. As she approached a road junction, the lorry turned left across her path and killed her in an instant.
Her mother's initial shock and bewilderment turned to outrage as details of the crash emerged. The anger intensified at the shoddy treatment she received from the police, Crown Prosecution Service and the coroner who investigated the death. When the driver escaped prosecution for causing death by careless or dangerous driving in 2001 after a police witness admitted in court that he could not read his own writing, Cynthia Barlow knew that she alone would have to take up the fight.
She bought shares in the company that owned the vehicle involved and vowed to change from within a lax safety culture to prevent further deaths on the roads. A decade later, the biggest ready-mix concrete supplier in the country, Cemex, has become a leader in cycle safety, hailed by cycling groups and copied by other haulage businesses that are starting to adopt similar training schemes and technological solutions such as fitting extra mirrors and proximity sensors to their lorries.
Ms Barlow's fight reverberates through City Hall, where officials are drawing up draft contracts attaching strict conditions for safety measures for subcontractors on all public works. The biggest building projects, such as Crossrail, have already adopted many of the measures Ms Barlow fought to introduce.
But construction vehicles, particularly concrete mixers, tipper trucks and skip lorries, still pose a danger to cyclists. Many small hauliers, often owner-operators on tight piece-rate contracts, have little or no cycle awareness training or technology to guard against fatal collisions.
Last year in London alone, 13 of the 16 cycle fatalities involved a lorry, van or bus. It is a problem in all cities where large numbers of cyclists cross paths with heavy vehicles.
"I just became absolutely determined to do something," Ms Barlow said. "That is when I decided that I was going to buy shares in the company and go to their next AGM and speak about what had happened and ask them to do something about it in the same way as they would if there had been a work-related death on site. I had never done anything like that before. I was absolutely terrified. There were lots of men in suits with cigars — not my comfort zone."
A director of Ready Mix Concrete contacted Ms Barlow soon after the AGM and said that it was willing to work with her. Initially, the company made a training video to raise drivers' awareness of cyclists.
In 2007, Cemex, which took over RMC, began fitting sensors and mirrors to its fleet of 500 ready-mix lorries and 420 cement tankers and tippers. Four censors along the left-hand side detect cyclists or other obstructions within 2 metres of the lorry when the driver indicates to turn left.
An audible warning outside the lorry tells cyclists that it is turning and an alarm sounds inside the cab to alert the driver to unexpected obstructions. Bars have been fitted to the nearside to prevent cyclists from being thrown under the wheels. Six mirrors are fitted to try to give a view of the blind spots around the cab.
The £600 cost is minimal for a £75,000 lorry. Another major contractor, Conway, has begun fitting the first 21 of its lorries with similar technology. Transport for London has recently written to the major fleet operators asking them to consider sideguards and safety devices.
Despite her years of anguish, Ms Barlow has not given up. She works with Transport for London, the London Cycling Campaign, the Ministry of Justice and the charity Road Peace to try to prevent further tragedies. "It has completely taken over. I had a plan that when I retired I was going to paint because painting is my way of keeping sane, but it didn't work out like that," she said. "I am still absolutely heartbroken. The best person in my life was my daughter."
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The government is neglecting its promises to cyclists
The cycling and walking investment strategy pledges £300 million over five years, which is less than 14 per cent of the recommended amount
A minister labelled cyclists "the biggest challenge for a commuter", as the number found guilty of neglect of traffic directions more than doubled
Mary Bowers, 31, who has been left with severe brain damage after suffering "appalling" injuries, will need to receive care for the rest of her life
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text:
DenimBlog.com › Blog › Celebs in Jeans › Celebs in Denim: Kelly Monaco in Desert Blue Bullhorn jeans
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Celebs in Denim: Kelly Monaco in Desert Blue Bullhorn jeans
Actress Kelly Monaco was spotted grabbing a Starbucks in her Desert Blue Bullhorn jeans in Smoke wash. Not everyone can pull off super tight jeans but Kelly worked it out!
Thanks to HonestForum member Virgoddess for IDing Kelly's jeans!
9 responses to "Celebs in Denim: Kelly Monaco in Desert Blue Bullhorn jeans"
her thighs look so big.
Are you serious? I would kill to be able to wear my jeans THAT skinny.
She looks great and Lis is just jealous!
in love with her shoes! jeans are a bit tight but she has an amazing body- wish I could pull that look off
Those shoes kick a$$!
love the hold-your-drink-with-your-chin-while-getting-out-of-the-car method
Whoa- those are second-skin skinny! They look really tight but she pulls it off
She's super hot but I'm also impressed by the Starbucks balancing act.
which kar is in the photo?