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and the List sadly goes on:
85- Rama Al-Shandi, 1 year old, killed as four F16s airstrikes hit former security compound Al-Saraya in Gaza City.
In an Israeli attack on Al-Qarara area to the south of the Gaza Strip, two farmers were killed at 8:50 am:
86. Ibrahim Suleiman al-Astal, 46 years old.
87. Omar Mahmoud Mohammed al-Astal, 14 years old.
As a warplane rocked a motorbike in Khan-Younis, southern the Gaza Strip, two people were killed:
88. Abdullah Harb Abu Khater (21)
89. Mahmoud Saeed Abu Khater (34)
An Abatshi warplane fired a rocket at a car in Al-Berka street in Deer Al-Balah, killing three people:
90. Rashid 'Alyan Abu 'Amra (45)
91. Amin Zuhdi Bashir (40)
92. Tamer Rushdi Bashir (30)
93- Hussam Abdeljawad, killed as an F16 rocked his car in Saftawi street, northern Gaza, at 2:25 pm.
94- Ramadan Ahmad Mahmoud, 20 years old, died this morning after being seriously injured in an attack that hit Al-Maghazi camp, two days ago.
95- Mohammed Riyad Shamallakh, 23 years old, killed as IOF targeted a car in Tal Al-Hawa, southern Gaza city.
At around 4 am, two people were killed as an Israeli warplane fired a missile that hit Al-Nusseirat Camp, to the west of Gaza city.
96- A'ed Radi
97- Ameer Al-Malahi
In an attack on Al-Shorouq building in Gaza City which contains several media offices, 2 were killed and 3 journalists were seriously injured.
98- Ramez Harb
99- Salem Sweilem
100- Muhammed Ziyad Tbeil, killed in an attack than hit central Gaza.
At 6:55 pm, an Israeli warplane attacked Al-Bureij camp killing two people:
101- Arkan Abu Kmeil
102- Ibrahim Al-Hawajri
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1st Prize - Winning Entry Competition
Battersea - Center of Peace and Religion (Design Competition)
November 2012
1st Prize - Winning Entry Competition for a residential project in China
Lucheng Real Estate Co.Ltd
April 2014
Best High-End Commercial Architect 2015 UK
Build Magazine
September 2015
Most Innovative Architectural Start-up in the UK
corporate livewire awards
February 2016
Innovation Award for Civic Architectural Designs
February 2016
The sea front site is part of the Tower Area in Tripoli, in close proximity from the city centre. The site is total 11 hectares, all benefit from the beautiful sea front. The site is to become the new centre for retail, restaurant and recreational activities. The brief is asking for a business hotel of […]
The concept behind the form of this shopping centre was initially inspired by the properties of ribbons. Ribbons are used, and have been used throughout history, in dance performances to enhance dance movements and here we have used the ribbon form to enhance the design. The form of the walls and floors is as fluid […]
- Westminster
- Camden
- Kensington & Chelsea
- Greenwich
- Hammersmith & Fulham
- Wandsworth
- Havering to Lambeth
- Southwark
- City
- Islington
Debbie Flevotomou Architects Ltd + Uber Developments Ltd.
Millbank Tower 21-24
Millbank London SW1P4RS
This new two-storey, stainless steel extension is of a contemporary design which contrasts with the traditional design of the existing house.
The project in Richmond involved a rear extension of an existing kitchen into an open plan kitchen and dining area. The concept is based on the clean lines of the existing building in order to define the spaces
The Wentworth Estate lies in the tranquil heart of north Surrey. The grand neo-classical mansion, Wentworth Court, has been extensively refurbished and updated with nine bedroom suites, ten bathrooms, and full leisure facilities with its distinct historical character still intact.
Debbie has been a pleasure to work with and I have no doubt that we will work on many more projects together. She has an impressive CV and is extremely professional and competent. She did everything she said she would, when she said she would and at the price we agreed. I have no hesitation in recommending Debbie and her work.
Debbie is a great person to work with. Not only does she bring a wealth of knowledge and experience but her approach is extremely pleasant and friendly. She is very good in listening to what a client needs and would like to achieve and she is able to recommend the best solution. Debbie is very creative yet practical. She is also fun to work with and a very calming presence in sometimes stressful situations (not easy to have your house renovated and still trying to live in it!). I would definitely recommend Debbie!
Excellent to work with and highly recommended. A pleasure doing business with her.
We are extremely pleased to announce a new collaboration that will commence this winter between Debbie Flevotomou Architects and Uber Developments. We value our clients' time and understand they may have little time to look for and compare contractors and specialists consultants for their houses upgrade, renovation, extension, etc. Having a trusted, London-based contractor in our team will keep the budget, time schedule and the best level of quality consistent throughout the project.
Recently, we have been awarded "Best High-End Commercial Architects in the UK 2015". We design large scale commercial projects including skyscrapers however; we also design smaller scale residential projects. It is not the size of the project that is important to us, but rather the design. Our clients should want, and be willing, to have something different, progressive, and unique. We work very adaptively and are perfectly able to work within any budget constraints. Our client's budget concerns are something that we put at the forefront of priorities of all our projects.
Our clients chose our services to provide them with a design that enhances the artistic, monetary and personal value of their sites.
We offer a wide range of architectural services. This includes urban design, architectural design, interior design, furniture, and more. We produce 3D visuals of all our designs to help our clients understand and follow the design from the start to finish. Additionally, we oversee the construction of a project from inception to completion in accordance to the RIBA stages.
Our service is personalised and tailored to our clients' needs as they are heavily involved in the design process. During the design process the brief is always being evaluated and worked upon. This includes the project's uses, the space, and context which we thoroughly investigate in order to produce the best options for the client. We meet weekly to show them reports and brochures that outline the design process with a great selection of options. We produce the maximum amount of work for every project in order to give our clients the best choices. Some people may say having a wide range of options may confuse them, but truth be told they love it. At the end of each meeting, we have usually rounded it down to one or two, from which we can develop into a detailed design. If at any given time, a client decides to change the design, we are happy to incorporate any changes until we arrive at their ideal solution.

subset: commoncrawl


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Anne is approved to conduct lessons through WyzAnt Online. WyzAnt Online allows students and tutors to work remotely via video, audio, and collaborative whiteboard tools. For more information about how online tutoring works, check out WyzAnt Online.
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Lake Forest College
Temple University (Cert in Elementary Education) (Graduate Coursework)
Currently, I am a tutor in language arts, Spanish, and basic math and reading and have had great success with all my students. I am always looking for ways to help my students do well and promise to deliver five star service to either you or your child. In addition, I have been a substitute teaching at Charter Schools and done an excellent job teaching the lessons left by the regular classroom teacher.
For seven years I lived in Guadalajara, Mexico and taught ESL to children and adults. Also, I taught reading, writing, science and math to second graders and history, literature, and philosophy to high school students. I can help you in any area from basic English skills, to reading and writing and editing essays. My broad range of teaching experiences has shown me that no two people learn in the same way. Because of this, I try to tailor my teaching to the needs and learning styles of my students and am a big believer in Howard Gardners' Theory of Multiple Intelligences. Whatever type of learner you are, I will find material that will take you to the next level in your studies. Currently, I am a tutor in language arts, Spanish, and basic math and reading and have had great success with
$30 for a group. For a packet of 5 the price is $25 a lesson for $125 total.
Anne is approved to conduct lessons through WyzAnt Online. WyzAnt Online allows students and tutors to work remotely via video, audio, and collaborative whiteboard tools. For more information about how online tutoring works, check out WyzAnt Online.
If you're interested in online lessons, message Anne to get started.
Approved subjects are in bold.
In most cases, tutors gain approval in a subject by passing a proficiency exam. For some subject areas, like music and art, tutors submit written requests to demonstrate their proficiency to potential students. If a tutor is interested but not yet approved in a subject, the subject will appear in non-bold font. Tutors need to be approved in a subject prior to beginning lessons.
I am an elementary teacher who lived and taught in Mexico. During this time, I taught reading, writing, math, and science in English to second graders. In m class we did extensive work on the animals of the Rain Forest and prepared a presentation for the science fair.
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Currently, I tutor two children who are struggling in reading and math and am having great success with them. My work in these subjects makes me an excellent candidate to help your child improve his/her science grades. I hope you will contact me, so I can help your child succeed.
Hello, my name is Anne S. and for six years, from 2005-12, I taught reading, writing, speaking and listening in English. I have worked with children, adolescents, and adults helping some to learn English from the start and others to improve the skills that they had already obtained. Please contact me if you want a tutor who will work with you to achieve your potential.
I was an ESL teacher in Guadalajara, Mexico for six years. I have had experience with many different types of learners that has made me aware of the fact that no two people learn the same, so I work hard to tailor my lessons to fit the needs of my students. In addition, I have spent many hours learning Spanish, so I understand that learning another language can be a challenge. I look forward to hearing from you.
Currently, I am tutoring student who are struggling in reading English.
Hello, my name is Anne and for the six years, I taught English in Guadalajara. I have taught basic conversation skills, reading and writing and grammar and can use my experience to best help you.
Currently, I am a substitute teacher and a tutor. I love to study grammar and know a great deal about it. I hope I will hear from you soon.
For six years I taught English in Mexico and did a great deal of proofreading. I firmly believe that another pair of eyes can add a great touch to any piece of writing. I hope I will hear from you soon.
Hello my name is Anne and I am a reading tutor who has helped many students improve their comprehension. One of my students improved 10 points on a reading test. Please contact me so I can help you or your child on the road to better reading.
I am a reading tutor who has lots of strategies to help her students improve on standardized tests. One of my students improved 10 points on a reading comprehension test. Please contact me, so we can start working right away.
Hello, my name is Anne and for 6 years, I lived in Guadalajara, Mexico and became fluent in Spanish. I am at a C1 level as graded by the Instituto Cervantes of Spain.
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I take time to listen to my students and find out what their needs are, and then I design lessons that will best help them. I look forward to working with you. Thank you very much for your time.
Hello, my name is Anne and I am an ESL teacher who has taught reading and writing in English and has edited many essays as well. I understand a lot about spelling in English and have many strategies to help you. For example, we can look at specific rules and exceptions to them. Also I have a lot of mnemonic devices that are very helpful. I think I can improve your spelling a great deal. Hope to hear from you soon.
I am a certified TOEFL teacher. Currently, I am working with students who are struggling with reading.
From 2005-12, I taught ESL in Guadalajara, Mexico and helped many of my students gain excellent skills in all areas of English from speaking to writing. I hope I will hear from you soon.
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Hello my name is Anne and I love to write and help people with their writing as well.
For six years, I lived in Mexico where I taught English to both children and adults. Within this work, I taught writing to both children and adults.
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Currently, I am tutoring students who are struggling in reading and writing and enjoy this very much.
Please get in touch with me if you want a great writing teacher.
Excellent Tutor with Experience in Language Arts, and Spanish


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Pulikkottil Dr. Geevarghese Mar Julius, Patron of Indian Orthodox HeraldNewly consecrated Metropolitan of the Malankara Church, Pulikkottil Dr. Geevarghese Mar Julius graciously assumed the position 'Patron of Indian Orthodox Herald'.For a long time, Metropolitan Mar Julius (Fr. Dr. George Pulikkottil) was one of the Trustee Board Members of Indian Orthodox Herald.
Posted in Church News,Features,News | Read More »


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The Arkansas baseball team continued rise in the national polls on Monday, coming in at No. 20.
Click here for the original story.
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This Week in Markets and Democracy: Malaysia's Corruption Probes, Ghost Workers, and Lax OECD Bribery Laws
International Investigations Take Over as Domestic Malaysian Justice Fails
New evidence shows that transfers from troubled state investment fund 1MDB into Malaysian Prime Minister Najib Razak's personal bank accounts may top $1 billion—$300 million higher than previously thought. Yet Malaysian authorities continue to clear him of wrongdoing. The attorney general's office ended its case, saying it found no evidence of graft, and Parliament is delaying a long-awaited investigatory report on the fund. The government has also shut down a Malaysian news site reporting on corruption and threatened harsh punishments for journalists who leak "official secrets"—a thinly-veiled warning to would-be whistleblowers. Less politically malleable are international authorities who continue to probe the cross-border case. Singapore recently seized a "large number" of related bank accounts. Criminal proceedings in Switzerland allege misappropriation of up to $4 billion in state money. And in the United States, the Department of Justice opened an inquiry into Najib's U.S. real estate holdings and the Federal Bureau of Investigation (FBI) into the 1MDB case itself. Najib maintains the money was a political donation from an unnamed Saudi royal, a claim that conflicts with the growing financial paper trail.


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The vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review article we describe evidence suggesting that two dietary interventions, caloric restriction (CR) and intermittent fasting (IF), can prolong the health-span of the nervous system by impinging upon fundamental metabolic and cellular signaling pathways that regulate life-span. CR and IF affect energy and oxygen radical metabolism, and cellular stress response systems, in ways that protect neurons against genetic and environmental factors to which they would otherwise succumb during aging. There are multiple interactive pathways and molecular mechanisms by which CR and IF benefit neurons including those involving insulin-like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator-activated receptors. These pathways stimulate the production of protein chaperones, neurotrophic factors and antioxidant enzymes, all of which help cells cope with stress and resist disease. A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders.
Brain disorders of aging have recently become leading causes of disability and death, due to numerous advances in the prevention and treatment of cardiovascular disease and cancers. Several prominent risk factors for major age-related diseases, such as cardiovascular disease, type 2 diabetes and cancers, are also risk factors for many neurodegenerative diseases. These risk factors include a high calorie diet, vitamin insufficiencies (e.g. folic acid and antioxidants) and a sedentary life-style. Research efforts on neurodegenerative disorders have rapidly expanded in the past decade and those efforts have led to many promising therapeutic interventions to increase both health-span and lifespan. Many people live for eight or more decades and enjoy a well-functioning brain throughout their life-span. We therefore know that the human brain is capable of aging successfully. We are now at a stage where our knowledge of both the genetic and environmental factors which have been linked to unsuccessful brain aging, and their cellular and molecular consequences, can be utilized to provide the general population with advice on aging successfully. In this review, we will discuss two dietary strategies, caloric restriction and intermittent fasting, which could potentially be used to mediate successful aging and forestall the onset of certain neurodegenerative disorders (Fig. 1).
An increasing number of genetic and environmental factors are being identified that can render neurons vulnerable to the aging process. An understanding of how such causal or predisposing risk factors promote neuronal dysfunction and/or death is critical for developing approaches to preserve functional neuronal circuits. Similarly to other organ systems, cells in the brain encounter a cumulative burden of oxidative and metabolic stress that may be a universal feature of the aging process. Increased oxidative stress during brain aging can be found in each of the major classes of cellular molecules, including proteins, lipids and nucleic acids. Some oxidative modifications of proteins that have been observed in neurons during aging include carbonyl formation (Butterfield et al., 1997; Cakatay et al., 2001; Dubey et al., 1996), covalent modifications of cysteine, lysine and histidine residues by the lipid peroxidation product 4-hydroxynonenal (Papaioannou et al., 2001), nitration of proteins on tyrosine residues (Sloane et al., 1999), and glycation (Munch et al., 2000). A common oxidative modification of DNA, observed during brain aging is the formation of 8-hydroxydeoxyguanosine (Sohal et al., 1994). Each of these modifications of proteins, lipids and nucleic acids are also exacerbated in numerous degenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). AD can be caused by mutations in the genes encoding the amyloid precursor protein (APP) and/or presenilin-1 (PS-1) or -2 (PS-2). Each of these mutations results in an increased production of amyloid-β peptide which itself can increase the oxidative burden on neurons. AD leads to a progressive deterioration of cognitive function with a loss of memory. Neuronal injury is thus present in regions of the brain that involve the hippocampus and the cortex. AD is characterized by two main pathological hallmarks that consist of extracellular plaques of amyloid-β peptide aggregates, and intracellular neurofibrillary tangles composed of the hyperphosphorylated microtubule-associated protein tau. The β-amyloid deposition that constitutes the plaques is composed of a 39–42 amino acid peptide (Aβ), which is the proteolytic product of the APP protein. Interestingly, the APP and presenilin mutations have also been shown to decrease levels of a secreted form of APP that has been shown to promote synaptic plasticity (learning and memory) and survival of neurons (Furukawa et al., 1996; Ishida et al., 1997). PD is also a relatively common progressive neurodegenerative disorder affecting approximately 1% of the population older than the age of 65 years and approximately 4–5% of the population older than the age of 85. It is caused by a selective degeneration of the dopamine neurons in the substantia nigra. PD is characterized by tremor, rigidity and slowness of movements. Non-motor features, such as dementia and dysautonomia, occur frequently, especially in the advanced stages of the disease.
Throughout history, numerous societies have recognized the beneficial effects on health and general wellbeing of limiting food intake for certain periods of time, either for religious reasons or when food was scarce. The first widely recognized scientific study of restricted diets and their ability to extend life-span was published by McCay et al. (1935). McCay showed that feeding rats with a diet containing indigestible cellulose dramatically extended both mean and maximum life-span in these animals (McCay et al., 1935). Many studies have confirmed this result and extended it to mice (Weindruch and Walford, 1988; Sprott, 1997) and other species including fruitflies (Chapman and Partridge, 1996), nematodes (Houthoofd et al., 2002), water fleas, spiders and fish (Weindruch and Walford, 1988).
In this review we will attempt to indicate how, with dietary alteration, not only can life-span be extended but also potentially, health-span, i.e. the time of our lives in which we have a disease/pathology free disposition. We shall also investigate through which molecular mechanisms the benefits, on the whole organism, of dietary intake modification are derived. Variations of this basic dietary regime, now known as caloric restriction (CR), are the most effective way of extending the life-span of mammals without genetically altering them. More recently, another variation of CR, intermittent fasting (IF) or every other day feeding (EODF), has also been shown to extend life-span and have beneficial health effects. (Sohal and Weindruch, 1996; Goodrick et al., 1982; Ingram and Reynolds, 1987). Rodents maintained on calorie-restricted diets are generally smaller and leaner and have less body fat and smaller major organs than ad libitum fed animals (Weindruch and Sohal, 1997). They are generally more active, which may relate to the need to search for food (Hart and Turturro, 1998; Martin et al., unpublished data), and the normal age-related decrease in physical activity is markedly reduced in calorie-restricted animals (Means et al., 1993). However, these animals are more vulnerable to cold temperatures (Johnson et al., 1982), which is a major source of mortality for small mammals (Berry and Bronson, 1992). The amount by which life-span is extended has been shown to increase progressively as caloric intake is reduced, until the point of starvation. The time of onset of the dietary restriction (e.g. pre- or post-pubertal) and the duration of the CR regime also determine the amount by which life-span is extended. Crucially both CR and IF can diminish the severity of risk factors for diseases such as diabetes and cardiovascular disease in rodents (Anson et al., 2003; Wan et al., 2003). In many studies, implementation of the IF dietary regime results in an approximately 20–30% reduction in caloric intake over time. Maintenance of rats on this alternate day CR feeding regimen for 2–4 months results in resistance of hippocampal neurons to chemically induced degeneration (Bruce-Keller et al., 1999a,b). This reduced damage to hippocampal neurons is also correlated with a striking preservation of learning and memory in a water maze spatial learning task. Thus these dietary regimes could have a significant benefit for debilitating and prevalent neurodegenerative disorders such as Alzheimer's, Huntington's and Parkinson's diseases.
Data from the animal studies described in this review show that neurons in the brains of rats and mice maintained on CR or IF regimens exhibit increased resistance to oxidative, metabolic and excitotoxic insults. The critical question to ask with respect to these studies is, what are the underlying molecular mechanisms that account for the protection against this myriad of potent cellular insults? Investigators have addressed this important question by measuring numerous proteins and lipids that are known to play a role in protecting neurons against many different insults. We shall discuss and demonstrate what a complex physiological response to CR/IF occurs in the organism and how this may eventually translate to healthy aging.
From nature we know that the acquisition of available food forms one of the most profound behavior sets and thus removal of adequate food sources acts as a great driving force for engrained behavior and causes a certain degree of psychological and physiological stress in the organism. This paradigm, as with so many aspects of biology, extends even to the fundamental physiological and cellular processes within the organism. To exemplify this, several different stress proteins have been measured in the brains from rats maintained on either ad libitum or CR diets for 3 months. Examples of such stress proteins include heat-shock proteins and glucose-regulated proteins. These molecular chaperone proteins interact with many different proteins in cells and function to ensure their proper folding, on the one hand, and degradation of damaged proteins, on the other hand (Frydman, 2001; Gething, 1999). They may also interact with, and modify the function of, apoptotic proteins including caspases (Beere et al., 2000; Ravagnan et al., 2001). Levels of some of these chaperone proteins may be increased during the aging process as a protective response (Lee et al., 1999, 2000a,b). Cell culture and in vivo studies have shown that heat-shock protein-70 (HSP-70) and glucose-regulated protein 78 (GRP-78) can protect neurons against injury and death in experimental models of neurodegenerative disorders (Lowenstein et al., 1991; Yu and Mattson, 1999). Levels of HSP-70 and GRP-78 were found to be increased in the cortical, hippocampal and striatal neurons of the CR rats compared to the age-matched ad libitum fed animals (Lee et al., 1999; Mattson, 1998). Previous studies in this and other laboratories have provided evidence that HSP-70 and GRP-78 can protect neurons against excitotoxic and oxidative injury (Warrick et al., 1999; Yu et al., 1999), which suggests that they contribute to the neuroprotective effect of CR. These data may demonstrate that CR can induce a mild stress response in neurons, presumably due to a reduced energy, primarily glucose, availability. In addition to these subcellular stress responses it has been reported that IF results in increased levels of circulating corticosterone (Wan et al., 2003), which is usually associated positively with the stress-state of the organism. In contrast to detrimental stressors, such as chronic uncontrollable stress, which endanger neurons through glucocorticoid receptor activation, IF downregulates glucocorticoid receptors with maintenance of mineralocorticoid receptors in neurons which can act to prevent neuronal damage and death (Lee et al., 2000a,b). It may be that alternating periods of anabolism and catabolism, occurring during IF, may play a mechanistic role in triggering increases in cellular stress resistance and the repair of damaged proteins and cells.
Excessive neurological stress often takes the form of elevated levels of glutamatergic neurotransmission, e.g. in post ischemic events or epileptic seizures there can be an overload of cells with calcium, induced by the overt glutamate release that results in eventual cell death. This form of excitoxic cell death can be mimicked by the injection of kainic acid (KA) into the cerebral ventricles/brain regions of experimental animals. When the excitotoxic KA is injected into the dorsal hippocampus of mice it induces seizures and damage to pyramidal neurons in regions CA3 and CA1 (Duan et al., 2001). A significant increase in the survival of CA3 and CA1 neurons in the IF mice compared with mice fed ad libitum, after the kainic insult has been demonstrated (Anson et al., 2003).
As both IF and CR induce a mild stress response in brain cells this can result in the activation of compensating mechanisms, e.g. the upregulation of neurotrophic factors such as BDNF and glial cell line-derived neurotrophic factor (GDNF) as well as the aforementioned heat shock proteins (Bruce-Keller et al., 1999a,b; Duan and Mattson, 1999; Duan et al., 2003; Maswood et al., 2004). IF regimens have been demonstrated to ameliorate and attenuate neuronal damage and improve the functional outcome in animal models of neurological trauma such as stroke (Yu and Mattson, 1999) and also neurodegenerative disorders such as Parkinson's disease (Duan and Mattson, 1999), and Huntington's disease (Duan et al., 2003). The neuroprotective mechanism of IF is not known, but it has been reported that IF induces the production of brain-derived neurotrophic factor (BDNF) which was associated with increased hippocampal neurogenesis in rats and mice (Lee et al., 2002). One of the primary neuroprotective mechanisms attributed to BDNF appears to be the ability of BDNF-mediated activation of its cognate TrkB receptor which then entrains stimulation of multiple signaling pathways. Prominent amongst these TrkB signaling pathways is the phosphatidyl inositol 3-kinase (PI3K)/protein kinase B (Akt) pathway that has been implicated in several of the CR/IF protective mechanisms that will be discussed at greater length in this review.
Dietary fasting is known to result in an increased production of ketone bodies, e.g. β-hydroxybutyrate, which can be used by the organism as an energy source in the face of limited glucose availability (Mitchell et al., 1995; Vazquez et al., 1985). With respect to ketogenesis it appears that IF regimens seem to be more amenable to this energy production pathway than more strict CR protocols. Mice on IF regimens have been shown to weigh on average more than mice on CR regimens. They also have larger adipose reserves and a greater ketogenic response than CR mice. IF dietary regimes can develop a two-fold increase in the fasting serum concentration of β-hydroxybutyrate compared with mice fed ad libitum (Anson et al., 2003). This shift to ketogenesis may play a direct role in the cytoprotective effects of IF, because it has been reported that rats fed a ketogenic diet exhibit increased resistance to seizures (Bough et al., 1999), and that β-hydroxybutyrate itself can protect neurons in rodent models of Alzheimer's and Parkinson's diseases (Kashiwaya et al., 2000). Ketogenic diets, which promote a metabolic shift from glucose utilization to ketogenesis, are also prescribed for some patients with epilepsy (Gilbert et al., 2000) as this is prophylactic against the progressive excitotoxic neuronal damage and degradation that can occur if the condition is untreated.
During fasting or dietary restriction the primary alteration to the organism is the availability of glucose for oxidative respiration. The mechanisms by which energy is derived from alternate sources or how the remaining glucose is handled are germane to the extrapolation of the health benefits of CR/IF regimens. The importance of glucose handling efficiency for healthy aging can be demonstrated by the fact that glucose levels in the blood, integrated over time, have been postulated to lead to high levels of non-enzymatic glycation, a form of protein damage. CR has been shown to specifically attenuate oxyradical production and damage (Weindruch and Sohal, 1997) and non-enzymatic glycation (Cefalu et al., 1995).
Both IF and CR regimens have similar effects on insulin and glucose levels, i.e. reduction, yet interestingly they have different effects on serum IGF-1 levels and serum β-hydroxybutyrate levels, i.e. both these parameters are increased with IF compared to CR (Dunn et al., 1997; Anson et al., 2003). A longitudinal study on male rats (Masoro et al., 1992) demonstrated that CR decreased the mean 24-h plasma glucose concentration by about 15 mg/dl and the insulin concentration by about 50%. CR regime animals utilized glucose at the same rate as did the rats fed ad libitum, despite the lower plasma glucose and markedly lower plasma insulin levels. Therefore, it is proposed that CR either increases glucose effectiveness or insulin responsiveness or both, and that the maintenance of low levels of glucose and insulin control the beneficial and life-extending actions of CR. CR has also been found to reduce plasma glucose and insulin concentrations in fasting rhesus monkeys (Kemnitz et al., 1994). In addition, CR can increase insulin sensitivity in rhesus and cynomolgus monkeys (Lane et al., 1995 and Cefalu et al., 1997). A major reason for this emphasis being placed on the insulin–glucose control system in aging is the finding that loss-of-function mutations of the insulin signaling system result in life extension in three species: C. elegans (Kenyon et al., 1993; Wolkow et al., 2000), D. melanogaster (Clancy et al., 2001), and mice (Bluher et al., 2003). Overall, from many experimental studies, CR and IF seem to chronically reduce the circulating levels of insulin resulting in an eventual enhanced glucose mobilization and an enhanced insulin sensitivity, both of which serve to maintain a supply of glucose for the vital organs, central nervous system and gonads to support these critical organs in time of limited energy intake. The actual reduction of insulin receptor signaling mediated by reduced plasma insulin levels has an impact also on several other factors that profoundly impact upon the cellular response to CR/IF; this will be discussed in later sections.
There is mounting evidence to suggest that inflammatory processes could be critically involved in the development of age-related pathologies such as those observed in Alzheimer's disease. The activation of microglia in response to injury or during aging causes the induction of an inflammatory-like response. This response is typified and initiated by an enhanced expression of interleukin-1 in the stimulated microglia (for review see, Griffin, 2006). With this in mind it is therefore unsurprising that inflammatory cytokines may also be implicated in the CR/IF-mediated processes that ameliorate this neurodegeneration. Recent findings suggest that IFN-γ is an important mediator of neuronal plasticity, e.g. IFN-γ may enhance synaptogenesis, regulate synaptic plasticity and control neurogenesis (Brask et al., 2004; Vikman et al., 2001; Improta et al., 1988; Wong et al., 2004). It was recently reported that levels of IFN-γ are increased in circulating leukocytes of monkeys that had been maintained on a CR diet (Mascarucci et al., 2002). It has also been demonstrated that CR elevates the expression of IFN-γ in the hippocampus where it exerts an excitoprotective action of IFN-γ (Lee et al., 2006). Cytokines can also be produced by visceral organs outside the immune system and the central nervous system. Adipose tissue, which accumulates during aging and is specifically reduced upon CR or IF regimens, can act as an endocrine organ, which produces trophic hormones that are active throughout the body (Bordone and Guarente, 2005), e.g. tumour necrosis factor-α (TNFα). TNFα has also been shown to trigger insulin resistance in animals (Feinstein et al., 1993). In vitro cell-culture studies have shown that TNFα renders cells insulin resistant through a downregulation of glucose transporter synthesis as well as through interference with insulin receptor signaling pathways (Stephens et al., 1997) which we have seen are critically involved in healthy aging. In vivo, the absence of the TNFα receptor significantly improves insulin sensitivity which mimics the insulin-related effects seen in CR/IF animals. Interestingly, it has been shown that CR attenuates the age-related upregulation of nuclear factor (NF)-κB (Kim et al., 2000), which is a transcription factor that induces the expression of TNFα (Bordone and Guarente, 2005) in adipose tissue and the production of inflammatory cytokines in immune cells. Thus attenuation of TNF-α-induced insulin resistance may enhance the glucose utilization capacity of the organism, thus fending off the detrimental effects of excessive blood glucose that may occur in times of poor health and with advancing age.
Leptin and adiponectin are two hormones that are typically associated with the feedback control of appetite and satiety. Both of these factors are produced by adipose tissue (Meier and Gressner, 2004) which is of course profoundly affected by CR/IF regimes. In addition to its role in satiety, leptin, released into the circulation, reduces the level of stress hormones (Barzilai and Gupta, 1999) and increases thyroid activity and thyroid-hormone levels which both result in increased energy expenditure (Legradi et al., 1997). As we have seen, CR regimens tend to upregulate stress hormones in a tolerable manner and in addition they can downregulate thyroid hormones, potentially through this attenuation of circulating leptin levels (Barzilai and Gupta, 1999). However leptin's role in mediating the beneficial effects of CR may be secondary to its satiety role as it has been demonstrated that mice that lack leptin unfortunately demonstrate a reduced life-span, compared to ad libitum animals, and are obese (Allison et al., 2001). Adiponectin has been shown to trigger increased insulin sensitivity (Meier and Gressner, 2004; Pajvani and Scherer, 2003) via upregulation of AMP-activated protein kinase (AMPK: Wu et al., 2003). This kinase regulates glucose and fat metabolism in muscle in response to energy limitation (Musi et al., 2001), and has been shown to protect neurons against metabolic stress (Culmsee et al., 2001). Importantly, adiponectin levels rise during CR, which suggests that this adipose-derived hormone might also have an important contributory role in the physiological shift to an enhanced insulin sensitivity in these animals (Combs et al., 2003). Recent findings show that mice that have been genetically engineered to be lean live longer. Indeed, tissue-specific knockout of the insulin receptor in adipose cells prevents the tissue from storing fat, which gives rise to lean animals that live significantly longer than wild-type mice (Bluher et al., 2003). These data suggest that visceral adipose might be especially important in driving insulin resistance and pathogenesis (Bjorntorp, 1991).
As lower organisms, e.g. yeast and nematode worms, possess a considerably shorter life-span than mammals they have proved useful for the discovery of the molecular determinants of healthy longevity. It has become apparent that amongst the multiple factors that have been identified that control life-span in these lower organisms, many of these also link the alteration of caloric intake to the increase in health-span so desired by dietary interventions of disease processes.
One of the primary genetic determinants of replicative life-span to emerge from genetic studies in yeast is the silent information regulator 2 (SIR2). The SIR2 gene was denoted because it mediates a specific gene silencing action (Rine and Herskowitz, 1987). Inhibitory mutations of SIR2 can shorten life-span, and increased gene dosage of SIR2 extended life-span (Kaeberlein et al., 1999). The SIR2 ortholog in C. elegans was similarly shown to be a key determinant of the life-span in that organism (Tissenbaum and Guarente, 2001). As yeast and C. elegans diverged from a common ancestor about one billion years ago this may suggest that descendants of that ancestor, including mammals, will possess SIR2-related genes involved in regulating their life-span. As dietary regulation has also shown to be a powerful modulator of life-span it is reasonable to speculate that CR/IF and SIR2 genes may converge to play an important role in these multiple and complex physiological pathways. Mammalian homologues of the yeast SIR2 gene have subsequently been found and interestingly the SIR2 ortholog, SIRT1, may in part mediate a broad array of physiological effects that occur in animals on a modified diet, beit CR or IF. The family of proteins discovered that are encoded for by the mammalian SIR2 homologues are collectively termed sirtuins. Several recent reports have shown increases in SIRT1 protein levels in response to food deprivation (Nemoto et al., 2004; Cohen et al., 2004). In addition SIR upregulation has been shown in response to cell stressors, such as high osmolarity (Lin et al., 2002), thus the sirtuin family of proteins could be actively regulated by the mild, controllable stress induced by CR/IF. Sirtuins possess a relatively rare enzymatic capacity as they are NAD-dependent histone deacetylases (Imai et al., 2000; Landry et al., 2000). The mammalian SIRT1 gene product enzyme can, in addition to histones, deacetylate many other substrates. In this regard, SIRT1 was recently shown to deacetylate and downregulate NF-κB (Yeung et al., 2004). It is intriguing to speculate that the upregulation of SIRT1 by CR contributes to the observed increase in insulin sensitivity and reduction in inflammation, potentially through the control of the NF-κ/TNFα pathways.
Lin et al. (2002, 2004) have proposed a molecular pathway for SIR2 activation that potentially connects alterations in caloric intake to life-span extension. Upon CR/IF there is an initial increase in oxygen consumption and respiration, at the expense of fermentative processes. Fermentation is a typical mechanism by which cells can generate ATP and also store excess energy in the form of ethanol when glucose is abundant. This metabolic shift triggers a concomitant reduction in NADH levels. NADH acts as a competitive inhibitor of SIR2, so its reduction during CR/IF periods would be expected to upregulate the enzyme and thereby extend the organism's life-span in line with yeast and C. elegans studies. Consistent with this, ablation of mitochondrial electron transport blocked the effect of CR on life-span, and overexpressing NADH dehydrogenase, the enzyme that shunts electrons from NADH to the electron transport chain, increased the animal's life-span. Thus it appears then that CR/IF induces a more efficient use of glucose via an increase in respiration. In addition to this there is a transition in muscle cells from using glucose, which is to some extent, metabolized in ad libitum animals fermentatively (producing lactate), toward the use of fatty acids, which are oxidatively metabolized. This shift spares glucose for the brain, preventing neurodegeneration, and correlates with the characteristic enhancement of insulin sensitivity in muscle and liver seen in CR. Although the actions of sirtuins in the nervous system are only beginning to be explored, it has been reported that SIR2 (SIRT1 in mammals) activation through increased gene dosage or treatment with the sirtuin activator resveratrol can protect neurons against the pathogenic effects of polyglutamine-expanded huntingtin proteins in worm and mouse models of Huntington's disease (Parker et al., 2005).
Sirtuins also seem to play a role in mediating the effective role of adipose tissue in the physiological transference of the benefits of CR/IF regimes to the organism. One of the most important regulators of adipose tissue function is the peroxisome proliferator-activated transcription factor receptor gamma (PPARγ: Tontonoz et al., 1994). This receptor acts as a nuclear transcription factor that controls multiple genes connected to cell survival and responses to metabolic alterations. One PPARγ gene target, the aP2 gene, encodes a protein that assists fat storage. SIRT1 can act as a repressor of PPARγ, thereby downregulating genes such as the mouse aP2 gene (Picard et al., 2004). During fasting SIRT1 activation is followed by an enhanced binding to the aP2 promoter in adipose tissue. This causes a repression of aP2 gene expression causing an eventual promotion of fat mobilization into the blood to aid the organism's energy balance. Therefore, according to Bordone and Guarente (2005), upon manipulation of caloric intake there is a reactionary activation of SIRT1 in adipose tissue, which acts to reduce fat stores and probably resets hormonal levels to change the pace of aging. This strategy also makes evolutionary sense when it is considered that successful reproduction is also regulated by body fat and is shut off during CR, only to resume when available energy supplies become more abundant.
PPARs, as we have seen, are members of the nuclear hormone receptor subfamily of transcription factors. PPARs form functional heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. There are three known subtypes of PPARs, α, δ and γ. These nuclear receptor transcription factors regulate genes involved in nutrient transport and metabolism as well as resistance to stress. PPARs themselves also recruit other proteins in addition to the RXR to mediate their complete function. One such protein is the peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1 (PGC-1). This coactivator has been shown to be closely regulated by dietary alteration in lower organisms and higher mammals. PGC-1 exists in two isoforms, α and β, and these isoforms have emerged as prominent regulators of the adaptive responses to caloric deprivation. PGC-1 regulates the ligand-dependent and -independent activation of a large number of nuclear receptors including the PPARs. There has been reported an age-dependent reduction in PGC-1α (Ling et al., 2004) which may exacerbate the aging process. However in mice and primates CR has been shown to reverse this age-dependent decrease in PGC-1α, PPAR and regulated genes (Weindruch et al., 2002; Kayo et al., 2001).
PGC-1α, the first PGC family member identified was characterized as a protein that interacts with the PPARγ to regulate brown fat differentiation during adaptation to cold stress (Puigserver et al., 1998). This cold stress may be regarded as analogous to the physiological and psychological stress induced by caloric restriction. During CR/IF periods, when insulin levels are low, PGC-1α and PGC-1β gene expression is enhanced in rodents (Puigserver and Spiegelman, 2003; Herzig et al., 2001). PGC-1α was also induced in the livers of mice (Corton et al., 2004) and rats (Zhu et al., 2004) after longer term CR. PGC-1α and β can coordinately regulate genes involved in gluconeogenesis and fatty acid β-oxidation in a number of organs during fasting (Lin et al., 2002a, 2004a; Kamei et al., 2003; Kressler et al., 2002). Both these processes are beneficial to the maintenance of a healthy energy balance in times of limited food. Hence through PPAR activation extra supplies of glucose can be mobilized and alternate energy sources can be exploited. As well as PGC regulation during fasting, PPARα is also upregulated by fasting in liver, small and large intestine, thymus (Escher et al., 2001), and pancreas (Gremlich et al., 2005). A large number of genes involved in fatty acid β-oxidation, known to be regulated by PPARα are also increased in expression in response to fasting. During periods of fasting PPARα knock-out mice exhibit an inability to regulate genes involved in fatty acid β- and ω-oxidation and ketogenesis in the liver, kidney and heart along with lack of control of blood levels of glucose or ketone bodies bodies (Kroetz et al., 1998; Sugden et al., 2001; Leone et al., 1999).
Not only is the liver the energy-regulating core of mammals but it also represents one of the most significant stores of glycogen, nutrients and vitamins. One would therefore expect that there would be a critical link between alterations of caloric intake and resultant hepatic function. Thus it has been shown that CR protects the liver from a wide range of environmental stressors, many of which induce damage through circulating inflammatory mediators (Kim et al., 2002; Bokov et al., 2004). PPARα has been shown to regulate hepatic responses to diverse forms of stress. Mice pre-exposed to PPARα agonists exhibit decreased cellular damage, increased tissue repair, and decreased mortality after exposure to a number of physical and chemical hepatic stressors (Anderson et al., 2002; Wheeler et al., 2003). It appears that functional PPARαs are crucial for the CR-mediated protection of the liver from damage induced by hepatotoxicants like thioacetamide. Specifically, it was demonstrated by Corton et al. (2004) that PPARα knock-out mice, in contrast to wild-type mice, were not protected from thioacetamide by CR regimes. Lipid peroxide levels, associated with oxidative cell stress in the periphery and the central nervous system, are also significantly increased in aging. PPARα knock-out mice show a marked elevation in lipid peroxidation products compared to wild-type mice (Poynter and Daynes, 1998). Thus PPARα may influence aging through the regulation of multiple damage and repair processes after exposure to a plethora of endogenous or environmental stressors.
PGC-1 isoforms are transcriptionally or posttranslationally regulated in mammals by several signaling pathways implicated in the connection between CR/IF and life-span extension. These include forkhead box "other" (FoxO) transcription factors (through an insulin/insulin-like growth factor-I -dependent pathway), glucagon-stimulated cellular AMP (cAMP) response element binding protein (CREB), stress-activated protein kinases (p38 and c-jun N-terminal kinase) and unsurprisingly SIRT1. We shall discuss next how these factors interact to control the molecular mechanisms of CR/IF that impact upon translation to healthy aging.
In mammals, insulin and IGF-I bind to either insulin or IGF-1 receptors activating multiple signaling pathways. With respect to the aging process and the amelioration of degenerative disorders it seems that the most important pathway entrained by insulin/IGF-1 is the canonical phosphatidylinositol 3-kinase (PI3K) and serine–threonine protein kinases (Akt-1/Akt-2/protein kinase B [PKB]) signaling cascade. In C. elegans, this pathway determines responses to longevity and environmental stress (Guarente and Kenyon, 2000). Mutations in C. elegans which inactivate the insulin/IGF-I pathway, including Daf-2, the receptor for insulin/IGF-I or the PI3K ortholog Age-1, increase life-span as well as temperature and oxidative stresses. These effects require reversal of negative regulation of the stress resistance factor, Daf-16 (Libina et al., 2003). Daf-16 encodes a transcription factor containing a "forkhead" DNA binding domain. Overexpression of Daf-16 in worms (Henderson and Johnson, 2001) or an ortholog in flies (Giannakou et al., 2004) significantly extends their life-span. Daf-16 regulates the expression of an array of genes involved in xenobiotic metabolism and stress resistance (Murphy et al., 2003). Mammalian homologs of Daf-16 fall into the family of FoxO factors. There are four main groups of mammalian FoxOs, FoxO1, FoxO3, FoxO4 and FoxO6. FoxO transcription factors belong to the larger Forkhead family of proteins, a family of transcriptional regulators characterized by the conserved 'forkhead box' DNA-binding domain (Kaestner et al., 2000). These FoxO proteins control a wide array of genes that all are linked by a common mechanism in that they serve to control energy metabolim in the organism in response to environmental changes, e.g. restriction of available food. For example FoxOs control genes involved in glucose metabolism (glucose 6-phosphatase and phosphoenolpyruvate carboxylase: Nakae et al., 2001; Yeagley et al., 2001); cell death (Fas-ligand), reactive oxygen species detoxification (catalse and manganese superoxide dismutase, Kops et al., 2002) and DNA repair (growth arrest and DNA damage-inducible protein 45 and damage-specific DNA-binding protein 1, Tran et al., 2002).
Insulin receptor stimulation, during caloric intake, leads to activation of the PI3K/Akt pathway and resultant phosphorylation of FoxOs in mammals. Phosphorylated FoxO factors are recognized by 14-3-3 proteins which facilitate their transport out of the nucleus, reducing their transcriptional activity. Thus upon CR/IF there is a complex interplay between activation and inactivation of these FoxO factors. There are potentially beneficial effects of FoxO activation and inactivation depending upon the prevailing cellular conditions. Mammalian FoxO family members carry out functions that determine cell survival during times of stress including regulation of apoptosis, cell-cycle checkpoint control, and oxidative stress resistance (Coffer, 2003; Furukawa-Hibi et al., 2002). Activation of FoxO3 or FoxO4 leads to increases in cell-cycle G1 arrest (van der Horst et al., 2004) and increases in apoptosis (Motta et al., 2004) presumably as a way to eliminate cells damaged by oxidative stress. Thus alterations in the capacity to activate the PI3K/Akt pathways can have dramatic effects upon cell survivability and this process may be critical in transferring the positive effects of CR/IF to the organism. CR uncouples insulin/IGF-I signaling to FoxO factors by markedly reducing plasma IGF-I and insulin levels in rats (Sonntag et al., 1999). These decreases in circulating insulin/IGF-I levels result in decreased Akt phosphorylation in liver (Al-Regaiey et al., 2005) and decreased PI3K expression in muscle (Argentino et al., 2005). In addition there is a compensatory increase in the expression of FoxO family members by fasting (Imae et al., 2003; Furuyama et al., 2003) or CR (Al-Regaiey et al., 2005; Tsuchiya et al., 2004). Therefore, when insulin signaling is decreased, e.g. during CR/IF there are not only increases in nuclear/cytoplasmic FoxO ratios but FoxO factor expression as well (Imae et al., 2003; Furuyama et al., 2003; Al-Regaiey et al., 2005; Tsuchiya et al., 2004). Overall, multiple studies have revealed that downregulation of insulin/IGF-I signaling results in increases in the activity of FoxO factors, that critically regulate cell survival mechanisms, and that these alterations are found consistently in many diverse models of longevity among different species.
Many of the genes regulated by FoxOs are similarly regulated by the tumor suppressor p53, which has led to the speculation that these two genes may work in concert to prevent both deleterious aging and tumor growth. Consistent with this possibility, p53 and FoxO are both phosphorylated and acetylated in response to oxidative stress stimuli and UV radiations (Vousden and Lu, 2002; Brunet et al., 2004). In addition, both p53 and FoxOs bind to SIRT1 deacetylase (Luo et al., 2001; Vaziri et al., 2001). FoxO and p53 seem to be functionally linked as p53 can inhibit FoxO function by inducing serum and glucocorticoid induced kinase (SGK) -mediated phosphorylation of FoxO3 resulting in its relocation from the nucleus to the cytoplasm (You et al., 2004). FoxO3 has been found to prevent p53 from repressing SIRT1 gene expression. FoxO-induced repression of p53 appears to be mediated by the direct interaction between FoxO3 and p53 (Nemoto et al., 2004). That FoxO factors induce SIRT1 expression is consistent with the observation that SIRT1 expression is increased in rodent tissues when insulin and IGF-1 are lowered by CR (Cohen et al., 2004). In turn, SIRT1 itself can bind to and deacetylate p53 and FoxO transcription factors, controlling their activity. Mice harboring a mutation, which results in the activation of p53, display a significant reduction of life-span and exhibit signs of premature aging (Tyner et al., 2002). Interestingly, while activation of p53 in these mouse models reduces life-span, p53 activation still allows an increased resistance to cancer (Tyner et al., 2002), demonstrating that p53 causes tumor suppression at the expense of longevity.
One of the most important recent fields of caloric restriction study is the demonstration that CR may be able to prevent the generation of multiple forms of cancer itself. For example, in mice with genetically attenuated p53 levels CR increased the latency of spontaneous tumor development (mostly lymphomas) by approximately 75% (Hursting et al., 2001). It is therefore clear that there is a subtle and complicated relationship between these related factors that are linked together by changes in dietary energy intake.
In addition to negative regulation by insulin/IGF-1 signaling and p53, FoxO factors are regulated by the CREB binding protein (CBP) and a related protein, p300. Interestingly, cellular overexpression of CBP (Daitoku et al., 2004) or p300 (Fukuoka et al., 2003) enhances the ability of FoxO factors to activate functional gene expression. SIRT1 again seems to play a central role in adaptive changes to energy regulation as it can reverse the negative regulation of FoxO family members by CBP. Like PGC-1, SIRT1 levels are increased during CR in rat liver and are negatively regulated by insulin and IGF-I (Cohen et al., 2004). Additionally, the related family member SIRT3, a mitochondrial protein, exhibits increased expression in white and brown fat upon CR (Shi et al., 2005).
FoxOs seem to exist at a nexus between mechanisms that connect cellular stress responses to eventual survival mechanisms. For instance the stress-related protein kinase cJun N-terminal kinase 1 (JNK-1), which serves as a molecular sensor for various stressors actively can control FoxO transcriptional action. In C. elegans, JNK-1 directly interacts with and phosphorylates the FoxO homologue Daf-16, and in response to heat stress, JNK-1 promotes the translocation of Daf-16 into the nucleus. Overexpression of JNK-1 in C. elegans leads to increases in life-span and increased survival after heat stress (Oh et al., 2005). In D. melanogaster as well, mild activation of JNK leads to increased stress tolerance and longevity (Wang et al., 2003) dependent on an intact FoxO (Wang et al., 2005).
In conclusion it seems that FoxO transcription factors are promising candidates to serve as molecular links between dietary modifications and longevity. In conditions such as CR/IF where the circulating levels of insulin/IGF-1 are attenuated to improve euglycemia, FoxO nuclear translocation results in the upregulation of a series of target genes that promote cell cycle arrest, stress resistance, and apoptosis. External stressful stimuli also trigger the relocalization of FoxO factors into the nucleus, thus allowing an adaptive response to stress stimuli. Consistent with the notion that stress resistance is highly coupled with life-span extension, activation of FoxO transcription factors in worms and flies increases longevity. FoxO proteins translate environmental stimuli, including the stress induced by caloric restriction into changes in gene expression programs that may coordinate organismal healthy aging and eventual longevity.
We are approaching a comprehensive understanding of the various molecular mechanisms by which changes in caloric intake can be transferred to an enhanced survival of cells during the aging process. However the question remains whether CR and IF will have beneficial effects on humans. To date, there have been no well-controlled scientific studies to determine the effects of long-term CR on humans. Currently there are studies ongoing involving 30% CR in non-human primates (rhesus monkeys) and data so far from these studies look promising, in that they have supported the life- and health-extending properties of this dietary regime (Lane et al., 1995, 1996).
However, the excessive loss of body fat and the concomitant decline in sex steroids can lead to menstrual irregularities, amenorrhea, bone thinning and the development of osteoporosis in females. Perhaps a variation of the CR/IF protocols in which there is a milder caloric restriction combined with a change in feeding frequency may have a greater likelihood of compliance amongst human subjects. Hopefully this more gentle alteration of dietary food intake will still retain the benefits of the experimental regimes employed so far. It is worth noting that to date most studies using CR have compared the beneficial effects of CR to overweight (or even obese) age-matched control animals. It is unclear whether animals with a healthy bodyweight, that are able to partake in regular exercise and have some form of mental stimulation (as they would do in the wild), would benefit from a CR regime. Recent studies carried out with human subjects, subject to 25% CR, are however attempting to address this as they are employing control subjects with normal body-mass indices.
The development of a chemical CR mimetic may be a promising therapeutic avenue for the treatment of neurodegenerative diseases and to delay the aging process, as it would provide similar health benefits to CR (such as extending health- and life-span), while circumventing the long-term need to reduce food intake. However, it remains to be seen whether a CR mimetic would be a feasible drug to produce, especially since the appreciation of the processes whereby CR exerts its protective effects are still somewhat incomplete and the underlying mechanisms are proving to be very complex. One must also not discount the psychological effects of food intake in higher, more introspective, organisms such as humans. We possess an almost unique emotional connection with a huge variety of foodstuffs. Therefore removal of this psychological succour, during a CR/IF-like regime may partially counteract the physiological benefits of these paradigms.
The main factor that may negate the widespread implementation of CR/IF as an effective geronto-therapeutic is potentially the modern Western lifestyle of near constant work and persistently high stress levels. Hence, to build the society and technological advances that we are used to, we have left behind the feeding patterns of our ancient ancestors in favor of constant mental activity and limited physical exercise. Due to increases in our day to day activity we have an increased energy (mainly glucose) requirement while our physiology is largely still geared to a feast and famine pattern of energy intake characteristic of our hunter-gatherer homo sapiens ancestors. This dilemma between our modern society/behavior and our ancient physiology will represent a recurring problem for gerontology for years to come. Hopefully, with our rapidly advancing appreciation of our aging process we will not need to wait for our physiological evolution to catch up with our lifestyle.
This work was supported by the National Institute on Aging Intramural Research Program.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Brady's TavernRead MoreCome to Brady's Tavern to grab an American classic with a side of fries. Pair your entree with a glass of wine or draft beer — this restaurant has a fully-stocked bar to complement your meal. Tots and tykes will be right at home at this restaurant with its kid-approved food and ambience. Wifi access is totally free at Brady's Tavern, perfect for catching up on the news, hopping on social media, or even working. Choose wisely. Wait at home for delivery or come into this restaurant for carryout. At Brady's Tavern, you can easily find parking in the lot next door. If your preferred mode of transit is of the two wheel variety, you're in luck — there's tons of bike parking outside the restaurant. Who s hungry for great grub at a reasonable rate? Brady's Tavern s yummy creations will leave a mark in your memory but not a dent in your pocketbook. Brady's Tavern offers breakfast, lunch, and dinner, so stop by whenever is most convenient for you. When you have a hunger craving, head over to Brady's Tavern and treat yourself to an American classic. When you come to Brady's Tavern, you'll be beyond satisfied with a casual American meal.31231 Southfield RoadBeverly Hills, MI US
Franklin GrillRead MoreCome taste what Franklin Grill is doing to transform classic American cuisine. Take your pick of beer, wine, or other beverages offered on this restaurant's menu. At this restaurant, kids of all ages are welcome. Outdoor dining doesn't get much better than the beautiful patio at Franklin Grill. Keep it casual at Franklin Grill, and save that little black dress for a different occasion. The food's ready when you are. Come on in or carry out. Feed the gang at your next get-together with catering from Franklin Grill as well. Franklin Grill is conveniently close to a parking lot. Franklin Grill is a mid-priced establishment, with the average meal costing under $30. The menu at Franklin Grill includes breakfast, lunch, and dinner — stop by for your favorite meal. Stop putting off the best meal of your year and come into Franklin Grill's restaurant for some good old American favorites! Franklin Grill serves up a variety of American eats in a casual setting. Swing by today and munch on some of your favorite dishes. For an exceptional menu of American food that is highly-rated by all who try it, call Franklin Grill today.32760 Franklin RoadFranklin, MI US
Andiamo WestRead MoreWith plenty of hearty Italian options, patrons of Andiamo West can enjoy delicious dishes that taste like the real deal. Andiamo West serves food that not only tastes great, but is low in fat and gluten-free. This restaurant also provides alcohol, so diners don't have to worry about bringing their own bottle. Gather the whole family for a trip to this restaurant — everyone will find something to like (even the pickiest little eater) on the menu here. At Andiamo West, easily plan a night out with family, friends, coworkers and more — large parties are always welcome, and a private room is available for use. No need to be formal, business casual will pass. Feeling a little shy? Carryout is available. For the tastes of Andiamo West from the comfort of your next party, the restaurant also offers catering services. Hand your keys to the valet driver or choose your own spot in the lot next door. Prices are a bit on the higher side, so this might be a good pick for a special night out. If you are looking for a new lunch or dinner spot, make your way over to Andiamo West and fill up on Italian fare.6676 Telegraph RdBloomfield Hills, MI US
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Engine Performance problem
2003 Chevy Monte Carlo 6 cyl Front Wheel Drive Automatic 87000 miles
i was trying to install a new serpentine belt on my car. Now my belt tensioner will not re-tighten it will just spin. Is there anyway to fix this without going to the dealership?
Sunday, September 5th, 2010 AT 5:37 PM


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Discussion of charter schools is everywhere in the Ohio news. Everyone has an angle, including a few unexpected ones:
NOTE: Below is the text of a press release issued by Fordham today.
The Ohio Department of Education has awarded the Thomas B. Fordham Foundation's sponsorship operation a rating of "Exemplary," the state's highest mark, for our work sponsoring charter schools.
On a zero-to-100 scale, our scores are as follows:
"This recognition would not be possible without the hard work of the schools with whom we work," said Kathryn Mullen Upton, Vice President for Sponsorship and Dayton Initiatives "We look forward to continuing to improve our efforts to positively impact outcomes for the children in the schools that we serve."
The Department evaluates sponsors in three critical areas: quality practices, student academic outcomes, and compliance. Quality practices includes all areas of a sponsor's day-to-day work: review of proposed school applications, contracts, monitoring and oversight, renewal, school closure, technical assistance, and agency commitment. Student academic outcomes are evaluated based on learning gains made by students at different levels of proficiency. Compliance focuses on the extent to which a sponsor monitors the health and...
Boarding schools are often associated with the rich and the privileged; as such, they are seen as an out-of-reach option for low-income families searching for high-quality education. But in a world of ever-increasing school choice, must boarding schools remain out-of-reach? Do tuition-free boarding schools that serve primarily academically struggling, low-income children exist?
The answer is yes, they do—but they're extremely rare. A 2003 study from the University of Chicago interviewed policy experts, educators, child welfare and youth development professionals, and parents of children who attend boarding schools designed for students with social and economic disadvantages. The study concludes that "urban or community boarding schools represent a promising idea that deserves serious consideration." Yet the authors are careful to point out that many people harbor concerns "about the meaning of out-of-home settings used primarily by low-income or minority children." They cite America's troubling legacy of using boarding schools for shameful reasons can lead to understandable suspicions about residential education models for low-income, high-need youth.
However, there are examples of places where the residential education model is already in place and working—and where families are thrilled with the results. In 2009, New York Times Magazine looked at the...
Thank you Chairman Cupp, Ranking Member Phillips and members of the House Finance Subcommittee on Primary and Secondary Education for giving me the opportunity to present testimony on House Bill 64. My name is Chad Aldis, and I am the Vice President for Ohio Policy and Advocacy at the Thomas B. Fordham Institute.
In general, we are supportive of most of Governor Kasich's proposed education changes. Some of the provisions that we believe are critically important include:
To expound a little bit on the charter reforms: Fordham has spent a significant amount of time over the past year looking at Ohio's charter school sector and has sponsored national experts to study the state's charter schools. With that research in mind, we believe that some of the provisions proposed...
Ohio has been a hotbed of education reform in recent years, but two policy areas remain mostly virgin territory: teacher preparation and licensure. I tackled the former previously; now let's examine three significant problems with Ohio's approach to the latter.
1. Lack of content tests for early childhood licenses
According to NCTQ's 2014 State Teacher Policy Yearbook, Ohio is one of only four states in the nation that doesn't require all elementary teachers to pass a content test prior to licensure (see here for the Ohio details). A list of required assessments shows that early childhood (PK–3) teachers are only required to pass the Assessment of Professional Knowledge: Early Childhood (which tests pedagogical knowledge) and Early Childhood Education assessments. The second of these tests is intended to assess a candidate's content mastery, but closer inspection reveals that the only core content with its own, separate part of the test is language and literacy development. Math, social studies, and science content are smaller parts of "Domain III" which itself only accounts for 36 percent of the test. This 36 percent is divided among music, drama, creative movement, dance, visual arts, health, safety, and physical activity...
It's been a great year for the Buckeye State. LeBron is back—and the Cavs are rolling into the playoffs. The Ohio State University knocked off the Ducks in the national championship, the economy is heating up, and heck, state government actually has more than eighty-nine cents in its rainy day fund.
But if you've been following the education headlines, you might feel a little down. The fight over Common Core and assessments continues to be bruising. Legislators are seriously scrutinizing the state's problematic charter school law. Various scandals continue to plague local schools, and we're not that far removed from the meltdown in Columbus City Schools. To shake off the wintertime education blues, I offer my list of the top five most exciting things happening in Ohio education today.
1. Four for Four Schools
In 2013–14, forty Ohio schools made a clean sweep on the four value-added components of the state's school report cards, receiving an A on each one. This is an impressive feat. These schools had to demonstrate significant contributions not only to overall student growth, but also for their special needs, gifted, and low-achieving students. (Starting two years ago, Ohio began to rate schools on an...
As Ohio marches through testing season, concerns continue to surface over whether the state's New Learning Standards are in the best interests of Buckeye students. Though Ohioans are understandably focused on what these standards mean for their home, the relative success neighboring Kentucky is having with the standards might calm Ohio's fears—and perhaps inspire it to make its implementation more effective.
In February 2010, Kentucky was the first state to adopt the Common Core State Standards and incorporate them into the Kentucky Core Academic Standards (KCAS). Common Core was widely seen as a huge step up for Kentucky—Fordham called Kentucky's prior standards "among the worst in the country" and gave both the language arts and mathematics standards a D grade. Much like Ohio, Kentucky played a significant role in the drafting process for the Common Core. Teachers, the public, administrators, higher education officials, and the staff from three agencies (the Council on Postsecondary Education, the Education Professional Standards Board, and the Kentucky Department of Education) gave input and feedback on the standards.
The new standards were first taught in Kentucky schools in the 2011–12 school year. The state's implementation of Common...
Not much in the way of fireworks, but rather many points of agreement emerged during last week's Education Speakers Series event on teacher evaluations. Ohio Federation of Teachers President Melissa Cropper and Students First Ohio's State Policy Director Matt Verber began at the same point: teachers are the most-important in-school factor in student achievement. But when, how, and how much teachers should be evaluated were all matters of discussion. Both panelists felt there were questions to be resolved about the possible use of "shared attribution" for evaluating teachers. The question of whether student surveys should be used in evaluations generated no consensus. And the question of how evaluation data should be used – development vs. removal – proved a predictable bone of contention.
We appreciate the time and contribution of both our panelists in this important discussion, and thank our audience for their valuable questions and comments. If you missed the event, check out the full video:
And look for future events in our Education Speakers Series coming soon. Anything you want to see? Drop us a line: [email protected]. ...
Cheers to State Auditor Dave Yost, for going there. Charter law reform is a cause célèbre in Ohio. An influential report, a determined governor, and two bills being heard in House committees all feature excellent reform provisions, mostly in the "sponsor-centric" realm. But last week, Yost laid out some reform provisions that only an auditor would think of—things like accounting practice changes, attendance reporting changes, and defining the public/private divide inherent in many charter schools' operations. These are all welcome additions to the ongoing debate from an arm of state government directly concerned with auditing charter schools.
Jeers to Mansfield City Schools, for nitpicking Yost and his team as they attempt to help the district avert fiscal disaster. Mansfield has been in fiscal emergency for over a year, and their finances are under the aegis of a state oversight committee. Yost's team identified $4.7 million in annual savings opportunities. Instead of getting to work on implementing as many of those changes as possible, district administrators last week decided to pick holes in the methodology and timing of the report. Kind of like the teenager who swears "I'm going" just as Dad finally loses his cool. And the fiscal...
When Governor John Kasich released his proposed budget bill (House Bill 64), it generated immediate buzz in the Ohio education arena. Most of the conversation focused on charter reform and the proposed funding formula. What's gotten less attention are the policy proposals related to teachers. Here's a quick look at the most impactful provisions.
Easing requirements for consistently high-performing teachers
HB 64 mandates that by July 2016, the state board must not only define the term "consistently high-performing teacher," but must also adopt rules to exempt said teachers from completing additional coursework for renewal of their licenses. The provision goes on to also exempt these teachers from any requirements prescribed by professional development committees—committees in local districts that are responsible for determining if coursework and professional development meet state requirements for renewing teacher licenses. This seems like a decent idea for rewarding our best teachers for their talent and hard work, particularly since professional development has a bad reputation and the coursework in education programs is equally questionable. That being said, an inadequate definition from the state board of a consistently high-performing teacher could make this provision troublesome.
Changes to the Ohio Resident Educator...