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All Rise...
You know what game Judge David Johnson loves? Strip Hungry Hungry Hippos!
Editor's Note
Our review of For Love Of The Game, published April 4th, 2000, is also available.
The Charge
Billy Chapel must choose between the woman he loves and the game he lives for.
Opening Statement
That's nice, but do I really have to watch?
Facts of the Case
Mr. Billy Chapel (Kevin Costner, Field of Dreams) is a one-time powerhouse major league pitcher now on the tail-end of his career, looking at a looming retirement. His beloved Detroit Tigers are about to be sold and his final game of the season is against the dirtbag Yankees, who, according to this film, everyone including nuns in third world orphanages despise.
Before he takes the mound, he's hit with a piece of bad news: Jane (Kelly Preston), the love of his life, is taking off for London and Billy's not invited. This crushing revelation couldn't come at a worse time and despite the attempts to cheer him up by his best friend and catcher (John C. Reilly), Billy is a dude who's down in the dumps.
But with a hostile New York crowd jeering him and an intimidating batting lineup facing him, Billy will find himself on the cusp of pitching the greatest game of his life, fining time between strikeouts to reminisce back to happier days when he was frolicking with his beloved in his arms and the birds were chirping and the flowers were smiling and lollipop leprechauns told him magical stories about puppies and gumdrops and sunshine.
The Evidence
This is one corny movie. Maybe I'm a cold-hearted jackass, but I suffered greatly through the entirety of this film, didn't care a whit about the love story and found the baseball stuff cliché-riddled and boring. In short: this film was as entertaining and useful to me as a botched catheter.
Costner has done his share of baseball films and it's probably accurate to say he's the most familiar face with the genre. But For Love of the Game is the weakest I've seen. Nothing worked for me. It was the anti-Field of Dreams; I felt none of the emotions that were intended.
Adoration for baseball? Yeah, I'm a fan, but the baseball scenes were so ham-fisted and the big plays telegraphed (hey, do you think the outfielder who missed a pivotal catch years ago comes through with an amazing play this time? maybe he does, maybe he does), it was if I were watching a baseball-themed episode from Full House instead of a realistic sports movie. Worse were the monologues Chapel had with himself, a goofy element of the film where the character essentially gave a running color commentary of his current thoughts.
Heart-tugging feel-goodness from the love story? Ha, not even close. Look, I'll take a chick flick with the best of them, but at least make the love story halfway interesting. I may not possess as well-honed a sense of on-screen romance as others, but I can tell when the leads have the chemistry of a pair of lawn gnomes. Costner does his every-guy charm routine okay and Kelly Preston complains a lot and her character teaches her counterpart lots of valuable life lessons, all told as flashbacks between innings of the centerpiece game. How dopey and stale was the relationship stuff? I was actually yearning to be taken back to the dopey and stale baseball stuff.
General satisfaction for being entertained for two hours? Nope. When a film is compartmentalized into two storytelling approaches like this, and both flounder, there's not much to go to amusement-wise, except maybe giggling at the knowledge that Sam Raimi directed this before he was swimming in gold bullion and negotiable bearer bonds.
On the plus side, the HD DVD picture quality is impressive. Clocking in with a 2.35:1 widescreen, 1080p facelift, the video flaunts its high-def credentials well. The baseball scenes look great, with the expansive crowd features standing out. The sport sequences are captured masterfully as well with details holding strong throughout. It's a fine-looking treatment. Universal has gotten the lossless audio memo, too, with a TrueHD track pushing the sound, buttressed by two Dolby Digital Plus 5.1 mixes (English and French). As you would guess, the sound stands out most during the baseball game. The extras are lean: a boilerplate making-of featurette, deleted scenes, some text-only info on the history of the perfect game and a trivia game. Yawn.
Closing Statement
The idea was probably to combine baseball and romance into an all-powerful film that would attract both the men and the women. Too bad both of these elements whiff at the plate.
The Verdict
Give us your feedback!
Did we give For Love Of The Game (HD DVD) a fair trial? yes / no
What's "fair"? Whether positive or negative, our reviews should be unbiased, informative, and critique the material on its own merits.
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Master plan: The Casino Reinvestment Development Authority will look to hire a consultant to craft a master plan for the Tourism District. The master plan must be adopted by the authority no later than Feb. 1, 2012, state legislation rules.
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The U.S. House of Representatives pass a farm bill that includes an amendment allowing hemp research.
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The Heretic's Daughter: A Novel Audio CD – Audiobook, Unabridged
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From Publishers Weekly
Starred Review. A family's conflict becomes a battle for life and death in this gripping and original first novel based on family history from a descendant of a condemned Salem witch. After a bout of smallpox, 10-year-old Sarah Carrier resumes life with her mother on their family farm in Andover, Mass., dimly aware of a festering dispute between her mother, Martha, and her uncle about the plot of land where they live. The fight takes on a terrifying dimension when reports of supernatural activity in nearby Salem give way to mass hysteria, and Sarah's uncle is the first person to point the finger at Martha. Soon, neighbors struggling to eke out a living and a former indentured servant step forward to name Martha as the source of their woes. Sarah is forced to shoulder an even heavier burden as her mother and brothers are taken to prison to face a jury of young women who claim to have felt their bewitching presence. Sarah's front-row view of the trials and the mayhem that sweeps the close-knit community provides a fresh, bracing and unconventional take on a much-covered episode. (Sept.)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. --This text refers to an out of print or unavailable edition of this title.
"The panic and horror of the Salem witch trials in Kent's novel is conveyed with dead-eyed calm and an occasional tremor of emotion by Mare Winningham.... Her melodiousness is pleasing to the ear.... At times, the melody overwhelms the meaning, but Winningham is more than capable as a reader, and her reading of Kent's sad tale f women accused and accusing emits a hit of deeply buried, untouchable tragedy."―Publishers Weekly
"Powerful descriptions of 9-year-old Sarah's time in prison are depicted well by the fear, anger, and repulsion Winningham projects into her reading. Author Kent, a tenth-generation descendent of Martha Carrier, who was hanged as a witch in 1692, has an accurate vision for time and place, equaled by Winningham's narration."―AudioFile
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Top Customer Reviews
The Heretic's Daughter is a novel of the Salem Witch Trials. We have all heard of them, but Kathleen Kent has more than heard of them. She is a tenth generation descendant of Martha Carrier, who was hanged for a witch in Salem in 1692. Stories of Martha have been passed down through her mother's family for generations. Kent has taken fact and blended it with fictional license to tell the story of Martha, her husband Thomas and their five children.
The book opens with Martha's daughter Sarah writing a letter to her granddaughter in 1752, finally revealing the secret she has guarded for sixty years. From this letter, we go back and relive Sarah's past.
I'm not going to go into much more plot detail. Kathleen Kent spent five years researching and writing this book. Her attention to detail and descriptions of people, events and attitudes bring this terrible time in history alive on the page. I was moved by the love and fortitude of this family - I was crying my eyes out at the end.
This was such a powerful debut novel. I can't wait to read her second.
The story begins with the Carriers, Thomas & Martha and their children Richard, Andrew, Tom, Sarah, and Hannah, traveling to Andover where Martha's mother has a farm they will work. Their hopes of leaving smallpox behind them in Billerica are soon dashed when Tom becomes ill and their household is given a Bill of Isolation. Despite the quarantine, Sarah and her baby sister are bundled into the cart in the dead of night and delivered to their aunt and uncle in Billerica.Read more ›
I read it in one day and found that I could hardly put the book down. At the beginning it took a bit for me to get into it but once into it I really enjoyed the read.
The book was educational regarding the Salem Witch Trials. I had honestly thought that people in Salem had been burnt at the stake,they openly professed to worship Satan and called themselves witches.
I was all wrong and knew very little.
It is an extremely well written book and I loved how the author wrote it from the perspective of 9 year old Sarah.
I was amazed to hear the stories of that time period and the hardships that people had to go through just trying to survive. I guess reading so many hardships made it more meaningful to me on how difficult of a time period in our history it was for families to survive.
Not that you can compare this time period to the Holocaust but it definately has many overlaps regarding how some powerful people can place fear amoung the people, take over so much control and kill so many innocent people.
Control to choose who will be classified as a witch and hung and who will survive this terrible time period. This story is not just about the adults that were hung and imprisioned but also about the young children imprisioned in horricfic conditions.
Take time to read this unforgettable book and educate yourself so hopefully nothing like this will ever happen again.
How many times have we said this in history?
Too many!
It is up to us to make a difference!
The characters in the book were very well written. I loved the relationship between Sarah and her mother. Although strained, and even cold, it's a lot like the mother-daughter relationships today. When Sarah comes to terms with her mother, it's sad and quite possibly filled with regrets but it changes Sarah from a naive young girl to a mature one, who now sees the world in a very different way. I also thought her relationship with her father was interesting as well and it's an eye opener when she realizes that her parents are loving and caring even if they don't display it openly. I really did like reading this through Sarah's point of view. It's amazing and I really enjoyed her character development. I also liked Martha (Sarah's mother) as well. She was so strong willed and strong minded, she was an extremely admirable woman and her actions while in jail were extremely brave.
This book also got me to hate certain characters far more than usual.Read more ›
Most recent customer reviews
Enjoyed reading the story. It would have been a terrifying time to live in. The author gives an excellent sense of what it would have been like.Published on May 15 2013 by D. Varro
I loved it! the historical accounts were great. Hard to believe this kind of horror actually happened, not to mention the insanity of the masses.... Read morePublished on May 6 2010 by lafleurpetite


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South Africa Fed Cup team
From Wikipedia, the free encyclopedia
|South Africa
|Earl Grainger
|ITF ranking
|43 1 (16 November 2015)
|First year
|Years played
|Ties played (W–L)
|132 (82–50)
|Years in
World Group
|20 (26–19)
|1 (1972)
|2 (1973, 1992)
|Most total wins
|Natalie Grandin (33–18)
|Most singles wins
|Amanda Coetzer (25–9)
|Most doubles wins
|Natalie Grandin (18–5)
|Best doubles team
|Linky Boshoff /
Ilana Kloss (8–1)
|Most ties played
|Natalie Grandin (36)
|Most years played
|Natalie Grandin (10)
The South Africa Fed Cup team represents South Africa in Fed Cup tennis competition and are governed by the South African Tennis Association. They currently compete in the Europe/Africa Zone of Group II.
South Africa competed in its first Fed Cup in 1963. They won the Cup in 1972.
See also[edit]
External links[edit]
- Team page on FedCup.com
|This article related to Fed Cup (tennis) is a stub. You can help Wikipedia by expanding it.
|This article about a South African sports club is a stub. You can help Wikipedia by expanding it.


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Jorge Ramos Challenges Conservative Commentator Over Supporting Trump Even Though He "Has Said Racist Things"
Video ››› ››› MEDIA MATTERS STAFF
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Pastor Kenneth Adkins Previously Photoshopped A Government Official Onto Pornographic Images, Said Victims Of Orlando Massacre Got "What They Deserve"
The Florida Times-Union reported that pastor Kenneth Adkins plans to protest presumptive Democratic presidential nominee Hillary Clinton outside of the Democratic National Convention in Philadelphia this week. The paper's June 22 report failed to provide any context on Adkins and his well-documented history of rabid anti-LGBT extremism in political protesting, which includes photoshopping a government official's face onto pornographic images and most recently tweeting about gay people "gett[ing] what they deserve" after the June 12 mass shooting at an LGBT nightclub in Orlando, FL.
Adkins rose to prominence in local media earlier this year due to his extreme antics in protest of a proposed LGBT-inclusive nondiscrimination ordinance in Jacksonville, FL. The pastor opposed the ordinance on Twitter with graphic and inflammatory images. He said the definition of the ordinance was "Giving Civil Rights to men who engage in Anal Sex with each other," called Jacksonville City Council Member Tommy Hazouri the "anti-Christ" for supporting the ordinance, and photoshopped Hazouri's face onto pornographic images:
Last month, Adkins again made pages of the the Times-Union when he responded to the June 12 massacre at an LGBT nightclub in Orlando, FL, with a tweet saying, "been through so much with these Jacksonville homosexuals that I don't see none of them as victims. I see them as getting what they deserve." Adkins later attempted to deny that the tweet had anything to do with the Orlando shooting, though it came after a string of other tweets he wrote about the mass shooting.
The Times-Union's July 22 report on Adkins' planned protest of the Democratic convention failed to mention any of Adkins' past tweets or extremist protest tactics:
When Democrats gather in Philadelphia to nominate Hillary Clinton as their party's presidential candidate, Jacksonville-area pastor Ken Adkins plans to be outside, protesting their decision.
Adkins said Friday he's part of a slate of black and Hispanic activists scheduled to represent the conservative Douglass Leadership Institute and the Coalition of African American Pastors at a press conference Monday denouncing the former secretary of state for "hypocrisy and deception" on a range of topics.
A release from event organizers puts a sharp point on that, contrasting the effects of crime and arrests among minorities with the Justice Department's decision not to seek charges against Clinton for security lapses on the personal email server she used as secretary of state.
"Secretary Clinton has thwarted the law and perverted justice. Minorities are filling up jails at alarming rates for petty crimes and Hillary Clinton is not even indicted," the release said. "We are tired of the lies of the Democrat Party whose goal is to keep minorities enslaved and in mental deterioration by fostering government dependency that perpetuates generational poverty."
Video Claims "More People Murdered In A Day By Niggly Bears Than In A Year By Grizzly Bears"
CNN law enforcement analyst Harry Houck promoted a video that calls for President Obama to "ban niggas" in order to reduce violent crime, continuing Houck's long history of peddling racist tropes about the African-American community.
On July 25, Houck posted a link to a video on his Twitter account featuring Atlanta radio host and men's rights activist Tommy Sotomayor, in which Sotomayor said that Obama should "ban niggas" because black men commit more violent crimes than other groups. Houck tweeted the video with the comment, "He knows what he's talking about!":
Houck has used his platform on CNN to repeatedly suggest that African-Americans are prone to criminality and to blame black victims of police violence. Houck on Twitter has often warned about "black thugs," referred to Black Lives Matter as a "thug group," and even tweeted a link to a white supremacist website.
Houck continues to be employed as a law enforcement analyst by CNN. He most recently appeared during the the July 17 edition of CNN's Reliable Sources, where he attempted to link the shooting of three police officers in Baton Rouge to protests regarding the death of Alton Sterling.
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The media has spent years hurling sexist attacks at presumptive Democratic presidential nominee Hillary Clinton. From attacks on her appearance, her cleavage, her sexuality, her "PMS," the tone and volume of her voice, her laugh, her emotions, her age, being a grandmother, being called a "bitch,""castrating" and a "vaginal American," the claim that she's only successful because of her husband and more, it's hard to overstate the barrage of sexism Clinton has faced during her time as first lady, senator, secretary of state, and presidential candidate.
Now that Clinton is set to become first female presidential candidate for a major party in U.S. history, the media should avoid falling into this inexcusable cycle of rampant sexism and misogyny in their general election coverage.
James Edwards Celebrates Going "Mainstream" By Appearing At RNC With "All-Access" Media Credentials
Several members of Congress and a Trump campaign official gave pro-Trump interviews to white nationalist leader James Edwards and his "pro-white" radio show The Political Cesspool during the Republican National Convention. Edwards is a David Duke acolyte and "has probably done more than any of his contemporaries on the American radical right to publicly promote neo-Nazis, Holocaust deniers, raging anti-Semites and other extremists," according to the Southern Poverty Law Center. Edwards pointed to his attendance at the convention as evidence that he and his radio program are going "mainstream."
Following the ousting of former Fox CEO Roger Ailes amid allegations that he sexually harassed former network anchor Gretchen Carlson, The New York Times reported that a culture of sexual harassment and intimidation in Fox News may extend beyond Ailes. According to the Times, interviews with current and former Fox News employees revealed "instances of harassment and intimidation that went beyond Mr. Ailes and suggested a broader problem in the workplace."
On July 21, Fox News' parent company announced that Ailes would be resigning his position at Fox News but would receive $60 million and continue to work "as a consultant" with 21st Century Fox. Ailes' ousting from the company follows a sexual harassment lawsuit filed against him by former Fox News anchor Gretchen Carlson. According to The Washington Post, 25 women have come forward to make similar harassment claims against Ailes.
The New York Times reported on July 23 that Fox News may have "a broader problem in the workplace," that extends beyond Ailes after at least "a dozen women" told the Times that "they had experienced some form of sexual harassment or intimidation at Fox News or the Fox Business Network, and half a dozen more who said they had witnessed it. Two of them cited Mr. Ailes and the rest cited other supervisors." From the Times' report:
The investigation by Fox News's parent company, 21st Century Fox, focused narrowly on Mr. Ailes. But in interviews with The New York Times, current and former employees described instances of harassment and intimidation that went beyond Mr. Ailes and suggested a broader problem in the workplace.
The Times spoke with about a dozen women who said they had experienced some form of sexual harassment or intimidation at Fox News or the Fox Business Network, and half a dozen more who said they had witnessed it. Two of them cited Mr. Ailes and the rest cited other supervisors. With the exception of Ms. Bakhtiar, they all spoke on the condition of anonymity, citing embarrassment and fear of retribution. Most continue to work in television and worry that speaking out could damage their careers.
They told of strikingly similar experiences at Fox News. Several said that inappropriate comments about a woman's appearance and sex life were frequent. Managers tried to set up their employees on dates with superiors.
The women interviewed by The Times described similarly troubling experiences at Fox News and the Fox Business Network, a sprawling operation with about 2,000 employees on several floors of News Corporation's headquarters on Sixth Avenue in Manhattan.
The networks were run with an iron fist by Mr. Ailes, the founding chairman and a former Republican strategist, who established the channels as a lucrative profit center and an influential voice in conservative politics.
It is difficult to know exactly how much Mr. Ailes set the tone. The investigation into his conduct revealed findings troubling enough to compel 21st Century Fox executives to move quickly and arrange his exit. Beyond inappropriate language, Mr. Ailes was also accused by employees of kissing and intimate physical contact, according to three people briefed on the investigation, and of making propositions that included quid pro quo arrangements.
Female staff members told of problems with other supervisors as well. One current employee said that she was with a male supervisor in a closed-door, one-on-one meeting in 2009 when she asked to work on an assignment. He turned to her and said, "Sure," then conditioned it on oral sex. The woman said she laughed it off, thinking that she would face retaliation and be demoted if she told him that the comment was inappropriate.
Media figures explained how Democratic vice presidential pick Sen. Tim Kaine's (D-VA) Spanish language fluency will enable him to be "a hell of a good surrogate" for presumptive nominee Hillary Clinton with Hispanic voters.
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Following a sexual harassment lawsuit filed by former Fox News anchor Gretchen Carlson against former Fox News chairman and CEO Roger Ailes, 25 women have come forward to make claims of similar harassment against Ailes, according to a July 22 report from The Washington Post.
On July 21, Fox News' parent company announced that Ailes would be resigning his position at Fox News but would receive $60 million in a "consultant" position with 21st Century Fox.
The Washington Post highlighted the "locker room" mentality at Fox News, alongside new allegations in a July 22 article which reports there are now 25 women accusing Ailes of misconduct and harassment, dating back decades:
News of Carlson's firing, and the lawsuit she filed shortly thereafter, have now prompted 25 women to come forward with what they describe as similar harassment claims against Ailes that stretch across five decades back to his days in the 1960s as a young television producer, according to Carlson's attorney, Nancy Erika Smith.
Interviews with four of those women portray the 76-year-old television powerhouse as a man who could be routinely crude and inappropriate, ogling young women, commenting about their breasts and legs, and fostering a macho, insensitive culture. Among those who agreed to interviews is a 2002 Fox intern who spoke for the first time about her accusation that Ailes grabbed her buttocks and repeatedly propositioned her.
The signals sent by Ailes were quickly picked up by the employees, the former staffer said. Some women began showing up to news meetings in short skirts and blouses that showed their cleavage.
"It became common knowledge that women did not want to be alone with him," the former staffer said. "They would bring other men with them when they had to meet him. It became a locker room, towel-snapping environment. He would say things like, 'She's really got the goods' and 'look at the t--s on that one.' "
Sometimes, the former staffer said, Ailes made "jokes that he liked having women on their knees. The tone he set went through the organization."
Enrique Acevedo, who anchors Univision's late night daily news show Edición Nocturna, commented on Twitter on the contrast between the Republican convention of 2000, which featured both a Latino theme and Mexican Ranchera singer Vicente Fernández performing on stage, and this year's convention, which featured Trump's favorite anti-immigration sheriff Joe Arpaio. Translated from Acevedo's July 21 tweet:
"16 years ago, the Bushes invited Vicente Fernández to sing at the Republican convention. Today Trump brought Sheriff Arpaio. Progress?"
Hace 16 años los Bush invitaron a Vicente Fernández a cantar en la convención republicana. Hoy Trump trajo al Sheriff Arpaio. Progreso?
— Enrique Acevedo (@Enrique_Acevedo) July 22, 2016
A July 20 report on the Republican convention in The New Yorker highlighted a side event put together by the National Association of Latino Elected and Appointed Officials (NALEO) in which Republicans defended their stance on stricter voter ID laws. According to The New Yorker, these laws "appear to be suppressing the Latino vote," a point that is backed up by studies. According to The New Yorker, members of Hispanic media spoke out to debunk the myth that voter fraud is "overwhelming," with one noting that in decades of reporting, she had never "found that situation":
In the background of the discussion was an issue that runs deeper than Trump: for all its talk of reaching out, the Republican Party has taken steps that actually appear to be suppressing the Latino vote. The Party has tried to pass stricter voter-ID laws across the country, even though studies have found that fraud is exceedingly rare and the laws have a disproportionate effect on minority turnout. (A recent study found that Latino turnout is 10.8 percentage points lower in states with strict photo-ID laws.) Lori Montenegro, a Telemundo correspondent, questioned whether voter fraud was being hyped by Republicans, saying, "I haven't found evidence that there has been an overwhelming fraud."
Daniel Garza, who served in the Bush Administration, disagreed. "Well, I come from the Rio Grande Valley," in South Texas. "It happens."
"That's one place," Montenegro said.
Maria Hinojosa, the host of "Latino USA," on NPR, spoke up. "I just want to second Lori in saying that, in twenty-five years, in all of my reporting, I have never found that situation."
According to Univision.com, Univision News' efforts to reach the Trump campaign for comments always go unanswered, in part because Donald Trump is the first Republican presidential nominee in 20 years not to have a specialized Spanish-language communications team. The July 20 report explains that George W. Bush was the first to hire a spokesperson for Hispanic media, and that both John McCain in 2008 and Mitt Romney in 2012 followed his lead.
The Hill reported on July 21 that the signs written in Spanish that were "being waved at the convention" by attendees had grammatical mistakes. They read "Hispanics para Trump," failing to translate "Hispanics" and using the preposition "para" instead of the correct one, "por."
Turns out, when you photoshop white people out of pics from the #RNCinCLE, there's hardly anyone left.
Take a look:https://t.co/Q3PLDXkMuQ
— Fusion (@Fusion) July 22, 2016
The Daily Beast profiled "the shady network" of nativist groups whose work and data Donald Trump cited during the anti-immigration sections of his Republican National Convention acceptance speech, noting that the groups Trump cited are "omnipresent in efforts to demonize immigrants."
Trump's acceptance speech -- which the campaign made available -- includes 282 footnotes containing the sources for the candidate's claims, with the work of the Federation for American Immigration Reform (FAIR) and the Center for Immigration Studies (CIS) being cited multiple times. FAIR has been classified as a "hate group" by the Southern Poverty Law Center (SPLC) for its extreme anti-immigrant rhetoric as well as its "ties to white supremacist groups, and eugenicists." CIS, which FAIR's founder John Tanton also helped found, has been repeatedly criticized for its shoddy research work and is labeled an "anti-immigrant nativist" organization by SPLC.
As The Daily Beast points out, "CIS and FAIR provide the intellectual and organizational firepower for the immigration restrictionist movement" and their work always appears in efforts to "demonize immigrants." The article continued, explaining that at one point anti-immigrant groups like CIS and FAIR were "pushed to the margins of the conservative conversation on immigration" but were kept relevant "thanks in part to powerful devotees in the talk-radio world and immigration-restrictionist stalwarts like Reps. Steve King and Louie Gohmert." From The Daily Beast's July 22 report:
Trump's team blasted out links to Trump's remarks, including detailed footnotes showing the sources for his factual claims. And, unsurprisingly, many of Trump's arguments are based on data from organizations funded by radical population control environmentalist activists. For instance, he cited a report from the Federation for American Immigration Reform (FAIR) to undergird his argument that the federal government enables crime by not deporting more undocumented immigrants.
FAIR was founded by John Tanton, a virulently anti-immigrant nativist who has associated with white supremacists and dabbled in eugenics. He and his allies also fear that human population growth—particularly in the First World—jeopardizes the environment. Thus, they also back pro-abortion groups. This fact has left many on the right deeply concerned about citing their research or affiliating with their leaders. But not Trump.
Trump's speech also cited the Center for Immigration Studies—another group Tanton founded and helps fund. His team cited three different reports from CIS to support his assertions that immigration hurts American workers and that the federal government isn't deporting enough undocumented immigrants.
Along with NumbersUSA, CIS and FAIR provide the intellectual and organizational firepower for the immigration restrictionist movement. Their data and scholars are omnipresent in efforts to demonize immigrants, and they were all major presences during the 2013 Gang of 8 comprehensive immigration reform debate. Tanton and his funding link the three together.
In the pre-Trump era, these groups found themselves pushed to the margins of the conservative conversation on immigration. They never fully lost traction—thanks in part to powerful devotees in the talk-radio world and immigration-restrictionist stalwarts like Reps. Steve King and Louie Gohmert—but they had trouble. For several years, CPAC declined to give them airtime.
In the meantime, the Republican National Committee made an explicit effort to change the party's rhetoric on immigration.
That dream is dead. Instead, Trump characterized immigrants as murderous, dangerous, and barbaric.
In his America, migrants are would-be rapists and definite job-thieves.
It is, in the literal sense, a story of xenophobia—a view of the world predicated on the notion that anyone from a foreign country should be feared.


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This position will perform multiple complex projects in Upstream Process Development while maintaining project timelines. The position will serve as a technical lead for the development of robust high performing upstream processes with...


text: Updated from 11:09 a.m. EDT In a deal that will create the world's third-largest oil services company, Transocean Sedco Forex ( RIG) announced Monday that it would acquire R&B Falcon ( FLC) for stock valued at about $5.8 billion. The combined company will be the industry's largest offshore drilling contractor, with an equity market capitalization of $17.7 billion. Company officials said that the transaction should immediately add to the Houston-based company's cash flow, and that it would be "modestly" dilutive to earnings per share in 2001, but add to them thereafter. Under the terms of the deal, R&B Falcon shareholders will receive half a share of newly issued Transocean Sedco Forex stock for each R&B Falcon share, resulting in the distribution of an estimated 100 million shares. Based on Transocean Sedco Forex closing price of 57 11/16 on Friday, R&B Falcon shareholders would receive shares valued at $28.84. That's a 14.5% premium for R&B Falcon shareholders based on the Friday closing price of 25 3/16. Transocean Sedco Forex will also assume Houston-based R&B Falcon's approximately $3.0 billion of debt. Transocean Sedco Forex finished Monday regular trading down 4 1/2, or 8%, at 53 3/16, while R&B Falcon closed flat at 25 3/16. The companies said the transaction should be completed by the end of the first quarter of 2001, pending regulatory and stockholders' approval. The deal is expected to be tax-free to R&B Falcon shareholders. Victor E. Grijalva, chairman of Transocean Sedco Forex, said the deal would help expand the company's 72-rig offshore fleet, by adding R&B Falcon's 139 mobile offshore drilling units and marine barges. He also cited R&B Falcon's strong presence in the Gulf of Mexico. The two companies have already jointly designed and constructed 17 new mobile offshore drilling units, expected to be delivered by the end of the first quarter of 2001. Grijalva said in a statement the construction is part of the company's new-build capital expansion program, which he called the largest in the industry's history. The combined company will be the third-largest oil field services provider in the world -- behind No. 1 Halliburton, based in Dallas, and the New York-based oil services company, Schlumberger.


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ATLANTIC CITY — Gov. Chris Christie visited the Atlantic County Municipal Building on Tuesday to discuss the early success of the Atlantic Homeless Alliance's Single Point of Entry program, which assists individuals and families who are homeless or at risk of becoming homeless.
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text: Battle 1 Backpacker Heidi wants to fight! "Just time enough in this stop over for a quick battle." Format: 1v1 Singles RNG Adjust: 0% RNG roll for Pokemon: 2/50 (2) Servine (Move your mouse to reveal the content) (2) Servine (open) (2) Servine (close) Servine (F) Nature: Modest +1 SpA, -1 Atk Type: Grass Grass STAB; Immunity to Leech Seed and Worry Seed. 50% reduction in status effect chance of oncoming "powder" attacks. More mobile in areas with strong natural light sources. Superior senses in tall grass and forest areas. Able to use Wrap and Bind without losing focus. Abilities: Overgrow: (Innate) When this Pokemon's HP is lower than 33% (flat), the Base Attack Power of any grass attack is increased by two (2). (eg Giga Drain goes from 8 to 10, Solarbeam from 12 to 14) Contrary (DW): (Can be Enabled)This Pokemon's unique structure reverses stat changes it recieves in battle, both from its attacks and the opponents. At the end of the round, stat changes will still increase/decrease toward 0. Ability: Contrary Item: Grass Gem Stats: HP: 90 Atk-: 1 Def: 3 SpA+: 3 SpD: 3 Spe: 83 SC: 2 WC: 2 BST: 15 Attacks: Tackle Leer Vine Whip Wrap Growth Leaf Tornado Leech Seed Mega Drain Leaf Storm Glare Mirror Coat Twister Giga Drain Calm Mind Hidden Power Fire 7 Sunny Day Taunt SolarBeam Double Team Energy Ball Grass Knot Swagger Substitute Turn Order: Backpacker Heidi sends out his Pokemon and issues actions. Complications sends out the first Pokemon in his challenge list and issues actions. REFEREE ----------------- RNG roll for ability: N/A "Shes always so Contrary." Servine (F) Ability: Contrary Item: Grass Gem "Quick I have a tour to make!" Enable Contrary Leaf Storm [GEM] > Hidden Power > Leaf Storm [GEM]


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Developing Story
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January 20, 2012, Bruce Katz and Judith Rodin
January 19, 2012, Bruce Katz and Judith Rodin
January 18, 2012, Bruce Katz and Judith Rodin
January 17, 2012, Bruce Katz and Judith Rodin
January 10, 2012, Bruce Katz
December 5, 2011, Bruce Katz and Jessica Lee
November 14, 2011, Bruce Katz
November 10, 2011, Bruce Katz and Judith Rodin
October 20, 2011, Bruce Katz
September 15, 2011, Bruce Katz
July 26, 2011, Bruce Katz
July 13, 2011, Bruce Katz
May 2011, Martin Neil Baily, Bruce Katz and Darrell M. West
April 15, 2011, Bruce Katz
March 2011, Jennifer Bradley and Bruce Katz
February 8, 2011, Bruce Katz
January 31, 2011, Bruce Katz
January 26, 2011, Emilia Istrate and Bruce Katz
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Saturday Night Fever
Behind The Movie looks at the definitive disco film that captured a generation. The story of a dead end kid who finds glory on the dance floor was a dark tale; however, its soundtrack solidified ...
Risky Business
More than twenty years after Risky Business triumphed in theatres, the film is still providing audiences with the ultimate embodiment of teenage lust. In 1983, the rousing reel became a cinematic ...
American Pie
Four guys, one school, several women, and a three week deadline. The mission: to lose their virginity by the end of prom night. It was "do it or die" for a pack of close-knit, perpetually horny ...
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The Vancouver Symphony begins its 2016-2017 season with a family-friendly free outdoor concert in downtown Vancouver's Esther Short Park band shell on Thursday, July 28 from 6-8 pm
The concert, part of Vancouver's "Six to Sunset" Series, will feature a 70+ member orchestra led by guest conductor Daniel Boico and selections by three singers from the local troupe Opera Quest Northwest. The master of ceremonies will be OPB's Conrad Wilson.
Also returning this year will the Beacock Music instrumental "Petting Zoo" where kids can play a wide variety of musical instruments.
July 28, 2016
A free outdoor concert as part of the City of Vancouver's Six to Sunset series at Esther Short Park
Oct 1 & 2, 2016
November 5 & 6, 2016
December 3 & 4, 2016
The VSO Goes to the Movies: the music of John Williams and other iconic film scores
January 21 & 22, 2017
Marcelo Lehninger, guest conductor
Suite No.3 Bach
Symphony No.8 Beethoven
Piano Concerto No. 2 Brahms
Orli Shaham, piano
February 25 & 26, 2017
Iphigenia in Aulis overture Gluck
Concertino Weber
Introduction, Theme and Variations for Clarinet and Orchestra Rossini
David Shifrin, clarinet
Symphony No. 40 Mozart
April 22 & 23, 2017
Young Artist Winners TBA
Lyric Suite Grieg
Pines of Rome Respighi
June 3 & 4, 2017
Audience Choice TBA
Burleske for Piano and Orchestra R. Strauss
Sofya Melikian, piano
Symphony No. 2 Khachaturian
Returning for his 26th season with the Vancouver Symphony Orchestra,
Maestro Salvador Brotons
Our Mission
To enhance the quality of life in Southwest Washington by providing symphonic music of the highest caliber in live performances, through music education in the schools, the concert halls, and throughout the region.
Directions to Skyview Concert Hall: 1300 NW 139th Street. Coming from the south on I-5, take the 134th Street exit. Turn left (west) at the light. Follow this street for 1-2 miles past Fred Meyer - Skyview is on the right. (134th Street curves and turns into 139th Street – stay on this main road as the name changes from 134th to 139th.) (map)
The Vancouver Symphony Orchestra
- PO Box 525
- Vancouver, Washington
- 98666-0525
- Ph: 360-735-7278
- Fax: 360-906-0355
- E-Mail: firstname.lastname@example.com


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2016 Spring / Summer Belly Dance Class Schedule
Intermediate / Advanced ~ Mondays 5:30-6:30 PM
May 2, 9, 16, 23, (no class May 30 – Memorial Day)
June 6, 20, 27 (no class June 13)
July 18, 25 (no class July 4, or 11)
Beginning / Intermediate ~ Saturdays 11AM – Noon
May 14, 21, (no class May 7 or 28)
June 4, 11, 25, (no class June 18)
July 2, 9, 23, 30 (no class July 16)
Class Location
MACS – Movement Arts Community Studio (click here for a map)
525 E. Fountain Blvd., Colorado Springs
DIRECTIONS: The building is on the southwest corner of Fountain Blvd. and Royer St. From Fountain, turn south onto Royer then turn right into the parking lot at the end of the building (or park on the street). The studio door – with "MACS" on it in large letters – is the closest door to the parking lot and faces Royer St.
Class Pricing
$12 per class to drop-in
$55 five classes
$99 full spring-summer session
No refunds for missed classes. Tuition is due the first class of each month or session. Students starting in the middle of the month/session may pay a pro-rated tuition.
All existing punch cards will be honored!
How to Register
Call or email ahead to pre-register and reserve your spot or arrive 10 minutes early to register. 719.648.3302 or email@example.com
What to Wear & Bring
Wear comfortable exercise clothing and/or belly dance wear if you like: coin hip scarf, tassel belt (Tribal), harem pants, choli top, etc. We dance barefoot, but you may wear socks or dance shoes if you prefer. I recommend bringing a water bottle. Tribal students should bring zills (finger cymbals) if you have them.
Student Nights
Classes are supplemented by organized Student Night performances and haflas (dance parties) sponsored by local belly dance teachers.
* FatChanceBellyDance®, FCBD®, ATS® and American Tribal Style®, are federally registered trademarks of FatChanceBellyDance, Inc. For more information, please visit www.fcbd.com/about/legal.shtml.


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Holt Renfrew puts focus on service for latest openingJuly 29, 2016
Canadian department store chain Holt Renfrew is furthering its retail footprint in the greater Toronto area with the opening of a new store at Square One in Mississauga.
Canadian department store chain Holt Renfrew is furthering its retail footprint in the greater Toronto area with the opening of a new store at Square One in Mississauga.
Private aviation firm Sentient Jet is continuing its relationship with racehorse Nyquist, a partnership that began at the Kentucky Derby earlier this year.
French footwear and apparel label Berluti, which has been without a creative director since February, is reportedly considering designer Haider Ackermann to fill the role.
The Ritz-Carlton is painting a sensory picture of the boundless possibilities accessible at its properties with help from two Condé Nast publications.
French atelier Christian Dior is making a connection as it takes consumers behind-the-scenes of its autumn/winter 2016-17 fashion show.
U.S. jeweler Tiffany & Co. is continuing to strengthen its latest social campaign as it bids for awareness among today's youth.
Chinese department store chain Lane Crawford is giving consumers a relaxing retreat from the bustle of Hong Kong.
Luxury vacation rental network Primo Destinations is the latest to put a luxury twist on the home-sharing model.
Retailers looking for an upper hand on mobile this holiday season may want to boost their efforts to drive installs in September, when acquisition costs are at their lowest while install-to-purchase rates are still high, according to a new report from Liftoff.
Luxury automakers vastly outperform mass-market competitors in measurements of owner attachment and excitement, according to a new study by J.D. Power.


text: User submit: this EMS volunteer is too cute (30 Photos) By: Rick In: Hot Brigaders, User Submit Disliked Liked! Jan 6, 2016 0 0 0 Share on Facebook Share on Twitter + View as Slideshow 1 I am graduating this coming Saturday from St. Mary's College of Maryland and will be moving to the MVA area to continue my science career and will be in a program for 2 years working in genomics. I have been volunteering for 2 years in Southern Maryland and it is an absolute passion to be able to help the community. I was introduced to the Chive and the Brigade by some amazing Chivers who are part of the United States DCFD, Army and Navy, and I am too happy they got me hooked on them. 2345678910111213141516171819202122232425262728293031 Category: Hot Brigaders, User Submit Share on Facebook Share on Twitter +


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F1 Racing's editor is being ribbed - not for the first time, we should add - for having curly hair.
"You look like Ricciardo," grins Jenson as we sit down for this interview in the McLaren Brand Centre (because of course anyone with curly hair looks like anyone else with curly hair, right?)
"No," insists ace lensman Steven Tee, "it's Alain Prost."
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News / One Hit Wonders / Science
Giant Squid Found, Caught Alive [VIDEO] In Japan After Three Other 2014 Reports: How Much Sashimi Can The Dead Body Size Make?
By Robert Kuang | February 13, 2014 12:57 PM EST
Recent, another giant squid has been found measuring at 11 feet long off the coast of Japan.
According to Telegraph, the giant squid was found Monday evening off the Tottori prefecture coast, where fishermen were attempting to catch flatfish and crabs.
Amazingly, the giant squid was caught alive, but died before reaching shore on Tuesday.
Although it measured at 11 feet long, two of its longest tentacles were missing, which could have extended the creature to 26 feet long. Even so, it still weighted at a whopping 220 pounds.
Reportedly, the giant squid was caught 790 feet underwater, when they generally inhabit between 980 to 4,920 feet.
"This shows that the squid was swimming at that depth, so I think this is significant," says researcher Toshifumi Wada.
Many local residents immediately wondered how much sashimi this giant squid body could make. Sadly, the amount of ammonium would make it rather unpleasant to eat.
This is not the first 2014 report of a giant squid being found off the coast of Japan.
Last month, a giant squid was caught off the island in Niigata Prefecture measuring 13 feet long.
Last Sunday, a dead giant squid was also found washed ashore a beach in Kashiwazaki city in Niigata as well.
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Wacom Cintiq 21UX
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Kathy Cassidy
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
Anthony Grifoni
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
Steph Mundell
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
Andrew Mitsi
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
Simon Harriott
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.
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MIW-XT extends noise free, safe power from Panamax / Furman Power Management components to remote panel displays, ceiling mounted video projectors and powered sub-woofers. Discreetly hides behind electronic equipment for a neat, clean, code compliant and professional installation.
AC Circuit
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Chip Chick meets Intel's Genevieve Bell
ROSE Blog: Rikki's Open Source Exchange
Recently Chip Chick (aka Helena Stone) attended the IntelUpgrade event where she met Genevieve Bell. Genevieve, an anthropologist and Director of User Experience with Intel's Digital Home Group, led a session called Ethnography Update "Women & Technology".
Today Chip Chick posted a blog about Genevieve's session, which examined how women use technology in different places. Chip Chick observes, "It is fascinating to comprehend, that even though we are living in a global village where our own social and economic actions can effect others on the other side of the planet, and international communication between individuals is so common, that different communities in different places could use technology so differently, and manage to have such different desires for their use of technology." Read her entire post to learn more about Genevieve's session.comments powered by Disqus
Issue 26: Linux Shell Handbook 7th Ed./Special Editions
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SUSE Joins the Microsoft Test Drive Program
Customers can take a free test drive of SLES for HPC on the Azure Cloud
SiFive Launches a Line of Open Source Chips
San Francisco-based chip company announces their first fully open source chip platform.
Fedora 24 Released
The whole distro gets rebuilt on glibc 2.3
Canonical Announces Cross-Distro Support for Snaps
Ubuntu Vendor tries to solve app packaging and distribution problem across distributions.
ownCloud Forked
Founder of ownCloud launches the Nextcloud project.
HP Enterprise Unveils a Futuristic Computer
Will The Machine change the way future programmers think about memory?
CoreOS Announces Distributed Storage System
The new Torus distributed storage system is available under an open source license on GitHub
Google Beats Oracle in the Android Lawsuit
Juries decides Google's use of Java APIs Was Fair Use
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But if you are not using the latest Linux kernel, your system is insecure.
Linksys Says Yes to Open Source Firmware
Home routers will give room for custom firmware but still comply with FCC rules


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The microRNA (miRNA) class of non-coding RNAs exhibit a diverse range of regulatory roles in neuronal functions that are conserved from lower vertebrates to primates. Disruption of miRNA expression has compellingly been linked to pathogenesis in neuropsychiatric and neurodegenerative disorders, such as schizophrenia, Alzheimer's disease, and autism. The list of transcript targets governed by a single miRNA provide a molecular paradigm applicable for therapeutic intervention. Indeed, reports have shown that specific manipulation of a miRNA in cell or animal models can significantly alter phenotypes linked with neurological disease. Here, we review how a diverse range of biological systems, including Drosophila, rodents, and primates such as monkeys and humans, can be integrated into the translation of miRNAs as novel clinical targets.
The multi-functional role of RNA as a molecular regulator spans a broad range of classifications as protein-coding and non-protein coding RNA transcripts. Notably, the microRNA (miRNA) class of non-coding RNAs have been implicated in a vast majority of the established signaling cascades (Bartel, 2009). Brain-localized miRNAs are of particular interest for neurological diseases which have a complex etiology and no currently effective therapeutic options. The transcriptomic targets of an miRNA can encompass numerous cellular pathways, consistent with the extensive molecular disruption linked to neurological disease onset. In this review, we discuss how various model systems can be integrated into the translation of miRNAs as novel clinical targets in the treatment of neuropsychiatric and neurodegenerative disorders.
The conserved role of miRNAs in neuronal functions underscores their relevance in the molecular dynamics between normal and pathogenic mechanisms. Indeed, Drosophila, rodents, monkeys, and humans have all shown significant sensitivity to microRNA modulation (Jin et al., 2004; Ashraf et al., 2006; Elmen et al., 2008; Hollander et al., 2010). Notably, some core components of the miRNA processing machinery, guided by the RNA-induced silencing complex (RISC), are shared between lower vertebrates and primates, such as the Argonaute-interacting proteins, GW182 (Chekulaeva and Filipowicz, 2009; Chekulaeva et al., 2011) and the 5′ pocket motif of the Dicer-homologs (Park et al., 2011). Furthermore, regulation of long-term memory processes and associated synaptic proteins are controlled by the miRNA RISC pathway in a diverse group of species (Ashraf et al., 2006; Rajasethupathy et al., 2009; Gao et al., 2010; Konopka et al., 2010). Collectively, the previous reports indicate that epigenetic modulation by miRNAs are a principal component to central nervous system development and homeostasis.
Several of the more extensively reported brain-enriched miRNAs, such as miR-9, miR-34, miR-124, miR-128, miR132, miR-219, have predominantly identical mature sequences across species, including humans, monkeys, mice, and Drosophila (Kapsimali et al., 2007; Hu et al., 2011; Juhila et al., 2011). The conservation of those miRNAs spans from the 5′ seed region to the 3′ end of the transcript. Moreover, the precursor sequence for some of the brain-enriched miRNAs, including miR-9 and miR-124, are also identical between humans and mice, further supporting a highly conserved function for those transcripts.
In the past few years, an extensive list of published reports have emerged to support a significant role for miRNAs in the pathogenesis of psychiatric and neurodegenerative disease (Bilen et al., 2006; Lukiw, 2007; Hebert et al., 2008, 2009; Li et al., 2008, 2011; Wang et al., 2009, 2010, 2011; Beveridge et al., 2010; Nelson and Wang, 2010; Nunez-Iglesias et al., 2010; Shioya et al., 2010; Chandrasekar and Dreyer, 2011; Kocerha et al., 2011; Lee et al., 2011; Santarelli et al., 2011; Smith et al., 2011; Liu et al., 2012b). The pathogenic mechanisms underlying the development of psychiatric deficits and neurodegeneration are not always distinct, suggesting they may be ideally suited for therapeutic targeting by pleiotropic miRNAs. Reports have shown that the precursor and mature miRNA transcripts as well as the miRNA processing machinery itself, such as Drosha and Dicer, are all subject to disruption with neurological disease progression (Sun et al., 2009; Beveridge et al., 2010; Babiarz et al., 2011; Fenelon et al., 2011; Schofield et al., 2011). Notably, the miRNA-linked pathology can be provoked through either genetic or non-genetic (sporadic) anomalies (Rademakers et al., 2008; Kocerha et al., 2011).
Schizophrenia, autism, Fragile X syndrome, depression, addiction, and anxiety are a few examples of psychiatric diagnoses where altered miRNA profiles have been identified, and a summary of the dysregulated miRNAs and the biological source they were profiled from are outlined in Table Table11 (Jin et al., 2004; Abu-Elneel et al., 2008; Li et al., 2008; Pietrzykowski et al., 2008; Hunsberger et al., 2009; Yang et al., 2009; Zhou et al., 2009; Zhu et al., 2009; Beveridge et al., 2010; Hollander et al., 2010; Im et al., 2010; Sarachana et al., 2010; Saus et al., 2010; Xu et al., 2010a,b; Baudry et al., 2011a,b; Eipper-Mains et al., 2011; Ghahramani Seno et al., 2011; Haramati et al., 2011; Mouillet-Richard et al., 2011; O'Connor et al., 2011; Shaltiel et al., 2012). In schizophrenia, miRNA profiling has now been completed in several patient populations, primarily focused within the cortex (Perkins et al., 2007; Beveridge et al., 2010; Kim et al., 2010; Moreau et al., 2011; Santarelli et al., 2011). Although a majority of the miRNA profiling studies for neurological disease have been performed from brain, miRNA dysregulation has also been observed in other sources such as cerebral spinal fluid (CSF), plasma, serum, and peripheral blood (Schipper et al., 2007; Cogswell et al., 2008; Gardiner et al., 2011; Ghidoni et al., 2011; Lai et al., 2011). Beveridge and Cairns (2011) recently reviewed the various studies to compare and contrast the collection of miRNA results in schizophrenia. Interestingly, a few of the miRNA families, including the miR-15 and miR-30 families, have consistently shown disruption in several of the population analyses (Beveridge and Cairns, 2011). We examined the bioinformatic mRNA targets of miR-15 and miR-30 with Targetscan and found several mRNAs which are strongly linked with schizophrenia, including neuregulin and synaptotagmin (Kim et al., 2007; Kao et al., 2010).
Psychiatric symptoms can also co-exist in patients with neurodegenerative pathology, such as Huntington's disease (HD), Frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), all of which have shown miRNA disruption and is summarized in Table Table22 (Wang et al., 0000; Hebert et al., 2008; Packer et al., 2008; Hebert and De Strooper, 2009; Williams et al., 2009; Haramati et al., 2010; Jiao et al., 2010; Lau and de Strooper, 2010; Buckley and Johnson, 2011; Gaughwin et al., 2011; Kocerha et al., 2011; Lee et al., 2011; Martins et al., 2011; Minones-Moyano et al., 2011; Smith et al., 2011; Enciu et al., 2012; Mouradian, 2012). A pivotal role for miRNAs in neurodegenerative disease is further supported by numerous reports linking miRNAs with neurogenesis and neurodegenerative signaling cascades, and thus, overall neuronal density (Patel et al., 2008; Boissonneault et al., 2009; Gao, 2010; Magill et al., 2010; Schonrock et al., 2010; Shi et al., 2010; Cho et al., 2011; Shibata et al., 2011; Tao et al., 2011; Han et al., 2012; Persengiev et al., 2012).
Some miRNAs, such as miR-132, have been shown to be dysregulated in both psychiatric and neurodegenerative disease. miR-132 has been linked with schizophrenia (Perkins et al., 2007; Kim et al., 2010), addiction (Hollander et al., 2010), HD (Lee et al., 2011), AD (Cogswell et al., 2008), and progressive supranuclear palsy (PSP; Smith et al., 2011). Indeed, the wide range of neurological diseases in which miR-132 is disrupted is consistent with its principal role in neuronal plasticity and related functions (Magill et al., 2010; Remenyi et al., 2010; Mellios et al., 2011; Shaltiel et al., 2012).
A selection of cell and animal models have been engaged in the preliminary search for miRNAs with clinical relevance for neurological disease. Cell lines, primary cell cultures, differentiated neurons, and induced pluripotent stem (iPS) cells are a few of the platforms that have effectively been utilized for in vitro analyses (Cole et al., 2008; Agostini et al., 2011; Arias-Carrion and Salama, 2011; Kim et al., 2011; Saba et al., 2012). Indeed, cell-based systems have led to successful large-scale screening studies as well as in-depth molecular analysis of functional miRNAs (Vo et al., 2005; Cole et al., 2008; Connelly et al., 2012). For example, the discovery that neuronally enriched miR-132 is regulated by cAMP-response element binding protein (CREB) was initiated through a genome-wide screen in rat PC12 neuronal cells (Vo et al., 2005). Not all miRNAs will have a functional biological role, however, cell-based screens can facilitate the identification of promising candidates.
In parallel with the in vitro findings, studies in non-primate animal models have significantly advanced our understanding of miRNA biology in psychiatric and neurodegenerative disorders (Kocerha et al., 2009; Hollander et al., 2010; Lee et al., 2011; Li et al., 2011). Animal studies are a critical step in the progression toward testing of miRNA-based therapeutics in clinical trials. Our group examined the regulation of miRNAs in mice with pharmacological induction of a schizophrenia-associated behavioral phenotype (Kocerha et al., 2009). Likewise, a neurotoxin induced mouse model (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP) for Parkinson's disease (PD) was used to uncover a role for miR-7 in PD pathology (Junn et al., 2009). In addition to pharmacologically treated animal models, transgenic, knock-out and knock-in mice have also been valuable in vivo resources (Lee et al., 2011; Tao et al., 2011). Indeed, transgenic expression of the AD-causative amyloid precursor protein (APP) gene in mice provoked significant disruption in neuronal miRNA expression (Schonrock et al., 2010).
In addition to mice, rats as well as zebrafish and other vertebrate species have been integral in the study of neuronal miRNA pathways prior to testing in primate models (Yang et al., 2011; Tal et al., 2012). Indeed, recent reports identified miRNAs in zebrafish directly linked to neurobehavioral responses and neuronal differentiation (Tal et al., 2012). The exploration of miRNAs which regulate central nervous system functions, however, is not limited to vertebrate species. Drosophila, an invertebrate model, have been widely used for many years to examine or further define molecular mechanisms. Moreover, studies in Drosophila recently revealed that the conserved miRNA miR-34 mediates aging and neurodegenerative processes (Liu et al., 2012a), further substantiating that all biological models are applicable in the investigation of non-coding RNAs. Additionally, as each miRNA may regulate a number of transcripts and therefore off-target effects may result when altered, animal and cell models may help to filter out those candidates.
Arguably, a principal goal in the field of non-coding RNAs, including miRNAs, is to uncover transcripts which can ultimately lead to advancements in human health. Correspondingly, there are numerous studies which have profiled miRNA expression from humans with and without a disease diagnosis. Although some of those reports have focused on peripheral tissues, a subset of those analyses have specifically examined miRNA transcripts in distinct brain regions (Hebert et al., 2008; Kocerha et al., 2011; Santarelli et al., 2011). Genome-wide association (GWAS) studies and microarray profiling have both been used to identify miRNAs which are potential disease risk factors for neurodegenerative and psychiatric disorders (Rademakers et al., 2008; Hollander et al., 2010; Kocerha et al., 2011; Richardson et al., 2011; Ripke et al., 2011). Furthermore, there can be disruption of a cluster or multiple members within an miRNA family, such as with miR-29. In brain tissue from a cohort of Alzheimer's patients, miR-29a and miR-29b expression were both significantly repressed in patients with increased levels of beta-secretase/BACE1 (Hebert et al., 2008). BACE1 is a direct mRNA target for the miR-29 family and has consistently been linked to AD pathology. Therefore, correlation of expression for a miRNA and its targets in the transcriptome, as well as identification of disruption in miRNA families, can all contribute to effective discovery of new treatment alternatives for diagnosed patients.
The brain structure and related functions of humans and monkeys are strikingly similar (King and Wilson, 1975; McConkey and Varki, 2000; Paabo, 2001; Perkins et al., 2010; de Araujo et al., 2012), suggesting that monkeys are a relevant primate model for pre-clinical investigation of miRNAs in neurological dysfunction. Notably, certain key cell types in the brain linked to disease pathology, such as mirror neuron disruption in autism (Perkins et al., 2010), are primarily specific to primate physiology. Moreover, there is extensive conservation in miRNAs between primates, including those which are localized in the central nervous system (Brameier, 2010; Hu et al., 2011). One recent study reported that of the 413 miRNAs expressed in human brain, 366 of those transcripts are also detectable in rhesus macaque brain (Hu et al., 2011). Correspondingly, a number of those miRNAs are also detectable in mouse cortex and hippocampus by microarray and sequencing efforts, such as miR-9, miR-124, miR-128, and miR-132 (Juhila et al., 2011), suggesting that mouse models can be effective prior to testing in primates.
There have been considerable technological advancements in recent years with primate focused research, including with non-coding RNA biology. Groups have successfully delivered modified-antisense oligonucleotides (ASO) into monkeys to inhibit the function of specific miRNAs with minimal off-target effects (Elmen et al., 2008; Petri et al., 2009; Lanford et al., 2010). To date, the ability to modulate miRNAs in primates is restricted to peripheral administration, however, delivery of potential therapeutics across the blood brain barrier could be a future attainable milestone. Progress has also been made in other capacities with primates, including with the generation of transgenic monkeys. Our group established the first transgenic rhesus macaques in 2001 (Chan et al., 2001), which subsequently led to the development of a cohort for HD transgenic monkeys (Yang et al., 2008), a resource directly applicable to assess miRNA functions in a primate model of neurodegenerative disease. Moreover, from the HD monkeys we derived iPS cells which display a progressive cellular phenotype (Chan et al., 2010), providing an in vitro platform to complement the in vivo analyses for therapeutic and biomarker discovery, including non-coding RNA targets.
In primates, the progression of neurodegeneration and psychiatric deficits is typically gradual, developing over years, rather than weeks or months. Correspondingly, longitudinal analyses of molecular and neurobehavorial changes are fundamental to the monitoring and subsequent discovery of new treatments (Insel, 2009; Thompson et al., 2011). Indeed, longitudinal studies are readily implementable in primate species such as monkeys and humans, including collection of peripheral blood samples for molecular analysis throughout disease progression and parallel correlation with brain morphology by magnetic resonance imaging (MRI; Thompson et al., 2011; Waber et al., 2012; Zhang et al., 2012). The correlation of miRNA expression with disease trajectories may help identify functional non-coding RNA transcripts involved in neuronal pathogenesis.
As discussed above, a considerable number of in vitro and in vivo models are increasingly becoming available for miRNA functional studies. In conjunction, there have also been significant advances in the approaches to modulate or detect specific miRNAs. Viral and antisense-mediated targeting of non-coding transcripts are routinely applied to alter expression levels, however, technical improvements have allowed for increased effectiveness and efficacy. For example, locked nucleic-modified antisense oligonucleotides (LNA-ASO) significantly enhance the specificity and stability of miRNA silencing (Elmen et al., 2008; Stenvang et al., 2008; Kocerha et al., 2009; Hollander et al., 2010; Obad et al., 2011). Notably, the LNA-ASO can be administered in vivo to animal models through different routes, such as intracerebroventricular (icv) delivery to penetrate multiple brain regions (Kocerha et al., 2009; He et al., 2010), or local stereotactic injections for site-specific miRNA silencing (Gao et al., 2010; Hollander et al., 2010). LNA-modified probes also intensify the detectability of non-coding RNAs for in situ localization (Havelda, 2010), which facilitates examination of less abundant transcripts. There are other chemical modifications available for ASO, such as 2′-O-methyl RNA, 2′-O-methyloxyethyl RNA, and phosphorothioate RNA (Ruberti et al., 2011), some of which have also been successfully utilized in the context of in vivo silencing (Cheng et al., 2009).
In addition to viral and antisense methods, nanoparticle delivery of neurogenic miRNAs provide a means for brain distribution of selected transcripts. Just recently, reports showed that rabies virus glycoprotein (RGV)-labeled nanomaterials resulted in specific delivery of miR-124 to neuronal cells (Hwang do et al., 2011). Nanotechnology has also been employed to silence miRNA function, such as with miR-122 conjugated to gold nanoparticles in myeloma cells (Crew et al., 2012), suggesting this technology is effective in the repression or stimulation of miRNA expression.
Importantly, silencing of miRNAs in animal embryos have also provided significant insight to their role in brain development. Recent reports have shown that injection of morpholinos to block miR-9 activity in the embryos of Xenopus tropicalis (Bonev et al., 2011) or zebrafish (Tal et al., 2012) substantially altered neuronal functions in the developing animals. Furthermore, overexpression or silencing of miR-9 via electroporation in mouse embryos revealed that Cajal Retzius neuronal cell differentiation is regulated through Forkhead box protein G1 (FOXG1; Shibata et al., 2008). Collectively, these reports indicate that miRNA activity can be modulated in vivo at various developmental stages to assess their implications in brain functions.
Overall, the technical developments in miRNA biology mentioned above facilitate the translation of select miRNA transcripts for future clinical intervention. Indeed, there are human trials currently being conducted to assess miRNA-modulation in disease pathogenesis, including the use of LNA-ASO (Seto, 2010; Montgomery and van Rooij, 2011). To date, the reported human trials have focused on miRNA regulation in peripheral organs, however, therapeutic targeting of the brain remains a future objective. Polymer (Cheng and Saltzman, 2012), lipid (Shi et al., 2012), and polylysine (Jin et al., 2012) based nanoparticle modulation of miRNAs has also been reported. Although a majority of the nanodelivery methods for miRNA studies have focused on non-neuronal cells, there is great potential for their application to the central nervous system.
The discovery and development of miRNA-based therapeutics, as well as the diverse range of molecular cascades they can regulate, offer a new approach for treating diseases with a heterogeneic or epigenetic origin. There are numerous psychiatric and neurodegenerative diseases with no effective treatments due to their complex etiology and therefore may be ideally positioned for clinical targeting of pleiotropic miRNAs.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We thank Yerkes National Primate Research Center (YNPRC) veterinarian and animal care staff in providing outstanding services. YNPRC is supported by the National Center for Research Resources P51RR165 and is currently supported by the Office of Research and Infrastructure Program (ORIP)/OD P51OD11132. This study is supported by grant awarded by the ORIP/NIH (RR018827) and the American Recovery and Reinvestment Act (ARRA) Fund to Anthony W. S. Chan.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Due to essential maintenance some of our forms will be unavailable on Saturday 23 July 2016 from 3.30 am to 1 pm. We apologise for any inconvenience caused.
Bournville Tennants Conservation Area
Shortcut to this page: www.birmingham.gov.uk/bournvilletennantsca
Bournville Tenants Conservation Area was originally designated in 1971 and was extended in 1975.
It covers part of the Bournville Village Estate built by George Cadbury in the late 19th / early 20th Century.
The main estate is contained within the Bournville Village Conservation Area, however this conservation area covers the housing developed by Bournville Tenants Limited in the Kingsley Road and Northfield Road area.
A map showing the boundary of the conservation area is below, along with the designation report.
A Character Appraisal for Bournville Village was prepared but was never adopted as Supplementary Planning Guidance. A electronic copy of this document is not currently available however if you require a copy please contact us
Last Updated : 25th October 2013


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COSTA MESA, Calif. (BRAIN) — The National Bicycle Dealers Association has hired SJE Productions to assist with a number of marketing efforts in 2016.
CLEARFIELD, Utah (BRAIN) — Vista Outdoor Inc. has completed its purchase of the Bell, Giro, C-Preme and Blackburn brands for $400 million.
AIGLE, Switzerland (BRAIN) — The Union Cycliste Internationale and Red Bull Media House have agreed to a three-year extension and expansion of its exclusive television production and media rights partnership.
MADISON, Wis. (BRAIN) — Saris Cycling Group is adding 18,375-square feet to their current 50,000 square-foot facility.
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Gallarotti, 29, has spent the past five years working for Alpinestars.
LEVIS, Quebec (BRAIN) — Hawley-Lambert North America has bought the inventory, including proprietary brands, once distributed by Seattle Bike Supply.
TEMECULA, Calif. (BRAIN) — Intense has unveiled the light trail Spider 275C, which has been in development for over two years. And the company is taking a new approach to its sale and distribution.
SAN LUIS OBISPO, Calif. (BRAIN) — Six major shock makers announced on Thursday that they would each begin listing their rear shock fittings and lengths in metric rather than imperial units.
COLORADO SPRINGS, Colo. (BRAIN) — Steve Blank has joined USA Cycling as the executive director of the USA Cycling Foundation, the non-profit fundraising arm of USA Cycling for U.S. National and Olympic Team athlete development.
PROVIDENCE, R.I. (BRAIN) — Protective gear brand G-Form has added Steve Kwait to its sales team.
ASHEVILLE, N.C. (BRAIN) — PeopleForBikes' Ride on Atlanta — a 400 mile ride from here to Atlanta, Georgia — got going Wednesday morning with several NASCAR stars joining th efirst day's ride, a challenging 130-mile route to Charlotte, North Carolina.
VANCOUVER, British Columbia (BRAIN) — Mia Kohout has been hired as the new general manager of the new Vancouver Bike Share program, which is scheduled to launch early this summer.
LAKE FOREST, Calif. (BRAIN) — Spanish helmet brand Catlike is bringing its shoe line to the U.S. After launching a full line in Europe last year, the company is bringing select models to the U.S. for 2016.
BREMBATE, Italy (BRAIN) — 3T Cycling has hired SpinCycle Consulting, a firm launched by Kendall Young, to head up OEM sales efforts in the U.S.
Young is the former long-time North America sales director for Ritchey Design, and former national sales manager for Catalyst Communciation.
MILL VALLEY, Calif. (BRAIN) — DMAC — a new wool lifestyle clothing brand founded by Dave McLaughlin, a well-known member of the bike racing community — has reached its intial $12,000 startup goal on Kickstarter with about two weeks remaining in the campaign.
BOULDER, Colo. (BRAIN) — Organizers say they've registered more than 200 attendees for next month's Bicycle Leadership Conference, which will be held April 12-14 in Monterey, California.
ATLANTA (BRAIN) — Wahoo has issued a firmware update to its ELEMNT GPS bike computer, adding several new functions that work with some Shimano Di2 groups and SRAM's eTap drivetrain. The new firmware also adds support for muscle oxygen sensors.
BOULDER, Colo. (BRAIN) — The Pro's Closet's founders have sold a minority stake in the company to the investment firm Range Light LLC for $2.5 million and are preparing to launch its used bike trade-in program nationally.


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they are stealing cheap shares from weak hands..they know they can sell for more to shorts and newbies will come in since they all know this will be $15-17 within 3 weeks
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I thought this was a no brainer so I used marginto get in ASAP.Will transfer the money from savingaccount. No rush though.(And I hate using margin)
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hehe hope you are right...the 1st hours volume will be telling..already seeing the CNBC ticker..people will be buying at open..not only those shorts


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First in-game Skyrim footage released by Bethesda
Bethesda's released the first in-game footage of Elder Scrolls V: Skyrim, composed entirely of Xbox 360 material.
It's the first video of the game since its announcement back at the Spike Video Game Awards back in December.
Bethesda's community manager, Nick Breckon, confirmed the trailer is Xbox 360 footage.
"Just to clarify, all of this trailer was captured on Xbox 360. Also, the draw distance is not faked in any way," he wrote, reportedly in a NeoGaf post.
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Quality Money Management: Process Engineering and Best Practices for Systematic Trading and Investment / Edition 1by Andrew Kumiega, Benjamin Van Vliet
Pub. Date: 03/14/2008
Publisher: Elsevier Science
The financial markets industry is at the same crossroads as the automotive industry in the late 1970s. Margins are collapsing and customization is rapidly increasing. The automotive industry turned to quality and its no coincidence that in the money management industry many of the spectacular failures have been due largely to problems in quality control. The
The financial markets industry is at the same crossroads as the automotive industry in the late 1970s. Margins are collapsing and customization is rapidly increasing. The automotive industry turned to quality and its no coincidence that in the money management industry many of the spectacular failures have been due largely to problems in quality control. The financial industry in on the verge of a quality revolution.
New and old firms alike are creating new investment vehicles and new strategies that are radically changing the nature of the industry. To compete, mutual funds, hedge fund industries, banks and proprietary trading firms are being forced to quicklyy research, test and implement trade selection and execution systems. And, just as in the early stages of factory automation, quality suffers and leads to defects. Many financial firms fall short of quality, lacking processes and methodologies for proper development and evaluation of trading and investment systems.
Authors Kumiega and Van Vliet present a new step-by-step methodology for such development. Their methodology (called K|V) has been presented in numerous journal articles and at academic and industry conferences and is rapidly being accepted as the preferred business process for the institutional trading and hedge fund industries for development, presentation, and evaluation of trading and investment systems. The K|V model for trading system development combines new product development, project management and software development methodologies into one robust system. After four stages, the methodology requires repeating the entire waterfall for continuous improvement.
The discussion quality and its applications to the front office is presented using lessons learned by the authors after using the methodology in the real world. As a result, it is flexible and modifiable to fit various projects in finance in different types of firms. Their methodology works equally well for short-term trading systems, longer-term portfolio management or mutual fund style investment strategies as well as more sophisticated ones employing derivative instruments in hedge funds.
Additionally, readers will be able to quickly modify the standard K|V methodology to meet their unique needs and to quickly build other quantitatively drive applications for finance. At the beginning and the end of the book the authors pose a key question: Are you willing to change and embrace quality for the 21st century or are willing to accept extinction?
The real gem in this book is that the concepts give the reader a road map to avoid extinction.
• Presents a robust process engineering framework for developing and evaluating trading and investment systems
• Best practices along the step-by-step process will mitigate project risk, model risk, and ensure data quality.
• Includes a quality model for backtesting and managing market risk of working systems.
Product Details
- 9780123725493
- Publisher:
- Elsevier Science
- Publication date:
- 03/14/2008
- Series:
- Financial Market Technology Series
- Edition description:
- New Edition
- Pages:
- 304
- Product dimensions:
- 7.49(w) x 10.29(h) x 1.07(d)
Table of Contents
CHAPTER 1 Introduction
CHAPTER 2 Key Concepts and Definitions of Terms
CHAPTER 3 Overview of the Trading/Investment System Development Methodology
CHAPTER 4 Managing Design and Development
CHAPTER 5 Types of Trading Systems
CHAPTER 6 Stage 0: The Money Document
STAGE 1: Design and Document Trading/Investment Strategy
CHAPTER 7 STAGE 1: Overview
CHAPTER 8 Describe Trading/Investment Idea
CHAPTER 9 Research Quantitative Methods
CHAPTER 10 Prototype in Modeling Software
CHAPTER 11 Check Performance
CHAPTER 12 Gate 1
STAGE 2: Backtest
CHAPTER 13 STAGE 2: Overview
CHAPTER 14 Gather Historical Data
CHAPTER 15 Develop Cleaning Algorithms
CHAPTER 16 Perform In – Sample / Out – of – Sample Tests
CHAPTER 17 Check Performance and Shadow Trade
CHAPTER 18 Gate 2
STAGE 3: Implement
CHAPTER 19 STAGE 3: Overview
CHAPTER 20 Plan and Document Technology Specifications
CHAPTER 21 Design System Architecture
CHAPTER 22 Build and Document the System
CHAPTER 23 Check Performance and Probationary Trade
CHAPTER 24 Gate 3
STAGE 4: Manage Portfolio and Risk
CHAPTER 25 STAGE 4: Overview
CHAPTER 26 Plan Performance and Risk Processes
CHAPTER 27 Define Performance Controls
CAHPTER 28 Perform SPC Analysis
CHAPTER 29 Determine Causes of Variation
CHAPTER 30 Kaizen: Continuous Improvement
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