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Having held a number of high profile design roles within the industry, French designer Christophe Lemaire is now focused exclusively on his own label: Lemaire. "The determination was always there, but my experience at Hermès has given me even more confidence," said the designer at the close of his first show having left the leather house.
Since solely focusing on his own line, turnover almost doubled from €1.6 million ($1.8 million) in 2013 to €3.1 million ($3.5 million) in 2014 and, according to projections by the company, will reach €5.5 million ($6.2 million) by the end of 2015. Lemaire has also collaborated with Japanese retail giant Uniqlo, to produce a men's and women's collection, launching for Autumn/Winter 2015.
Lemaire first came to prominence as the artistic director of Lacoste. "It was difficult to do Lacoste and my brand. After a few years, I decide to put the brand on hold. It wasn't only a financial problem. There were issues with production, wholesale. My head was about to explode. I was doing the job that Sarah, Bastien and I are doing now. And I was doing it wrong. It was a thankless period, but it happened to be quite rewarding for the future," the designer told BoF. And, indeed it did — at one of the most prestigious luxury brands in the industry.
"When Pierre-Alexis Dumas called me, I was surprised, astonished, [but] at the same time, it seemed so obvious — the spirit of the brand — and we understood each other right away. We both had the idea of treating a piece of clothing as an object, but linked to functionality and realism," he said shortly after his appointment.
The announcement that Lemaire would replace Jean-Paul Gaultier at Hermès was initially met with surprise in the industry. Gaultier's tenure at the house had resulted in extraordinary commercial success. However, Lemaire quickly silenced his critics, crafting an aesthetic for the house that drew upon both his own paired-back simplicity and the heritage of Hermès to create effortless luxury. "I want… fashion that accompanies the personality," said the designer at the time. "Allowing freedom of movement and gesture, [the] clothes [should] allow a woman to be herself."
Lemaire took up his role as the artistic director of Hermès womenswear in 2011, his final collection for the house bowed in the Spring/Summer 2015 season. At the time Lemaire said in a statement, "Working for Hermès has been a great pleasure: a profoundly enriching experience on both a human and professional level. I am proud of what we have built together. My own label is growing in an important way and I now really want and need to dedicate myself to it fully."
Axel Dumas , chief executive of Hermès, said of the move, "I am very grateful to Christophe for the passion with which he has addressed and enriched the expression of our house in women's ready-to-wear. Under his artistic direction the métier has renewed its aesthetic and produced very satisfactory financial results."
Lemaire learnt his craft through internships at Christian Lacroix, Yves Saint Laurent and Thierry Mugler. His eponymous label, Lemaire, is stocked internationally and the designer, who works closely with his partner Sarah-Linh Tran, recently launched an e-commerce platform on his website. Most recently, Lemaire has teamed up with Uniqlo for a capsule collection that will launch in October 2015.


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Adam Levine's missing torso, Kristen Stewart's amputated arm and Beyoncé's thighs - it must be the latest round of Photoshop fails
They need less help than most of us mere mortals in the looks department, yet they continue to be on the receiving end of some far-from realistic airbrushing escapades.
No matter how beautiful, or famous, some celebrities are, it seems they are never far from an embarrassing Photoshop fail.
The latest handful of bloopers comes via some of the world's glossiest and most exclusive magazine titles.
No right side: Adam Levine looks like he is missing a fair portion of his torso in an image in Vogue Russia magazine. The Maroon 5 star was photographed with girlfriend, model Anne Vyalitsyna
Perhaps most bizarre is Russian Vogue's manifestation of Adam Levine's torso.
Pretty pair: Adam Levine and Anne V star in Vogue Russia's latest issue
The Maroon 5 singer and boyfriend of Russian model Anna Vyalitsyna, appears to have lost a sizeable portion of his midriff at the hands of over-enthusiastic digital re-touching in the November edition of the magazine.
Rather than slimming down the Californian rock star's toned figure, seen wrapped around Miss Vyalitsyna's never-ending legs, the 32-year-old - who in the past has stripped naked for UK's Cosmopolitan magazine in aid of testicular cancer awareness - is seen with gaping nothingness where his right side should be.
An editor at Photoshop Disasters, told MailOnline that the image 'certainly is a disaster and we believe that they removed his torso and maybe increased the width of her leg.'
Not limited to Vogue, Glamour magazine have also fallen prey to over-zealous digital enhancement.
Kristen Stewart, star of the Twilight Saga, appears to be missing her lower left arm on the cover of its November issue.
While the 21-year-old actress may be used to hocus pocus in her role as Bella Swan in the vampire series, there's no doubt that her hidden limb is incongruous in the shot, which was the responsibility of the same team who infamously gave singer Fergie different sized legs and a missing lower torso on a cover last year.
It all makes for an oddly imbalanced image, Miss Stewart's left arm coming to sudden halt at about chest height and disappearing behind her (very flexible) lower leg.
Arm fail: The beautiful figure of Twilight star Kristen Stewart is not quite complete on Glamour's November cover - the star apparently missing her lower left arm
Then there are Beyoncé's lovely legs.
The 30-year-old mega-star, whose first baby with husband Jay-Z is due in February, is a not a woman whose figure cries out for anything other than praise.
But photographer Terry Richardson felt the need to go to work on the Bootylicious star's thighs, shaving them to within an inch of their usually voluptuous lives for the cover shot.
Looking impossibly stick-like compared to her more usual - and indeed enviable - pins, the singer's legs contrast to the behind-the-scenes film from the shoot where they appear, apparently undisguised, their more healthy size.
The thighs have it: Beyoncé Knowles' upper legs seem on the over-airbrushed side on the cover of U.S. Harper's Bazaar, photographer Terry Richardson whittling the voluptuous star's legs to uncharacteristic proportions
The singer's stomach doesn't seem to hint of a baby bump - though in the film, again, the singer's stomach is clearly showing signs of the pregnancy, news of which brought Twitter to near-meltdown in August.
At a performance in New York that month, Beyoncé's legs again look their more typical curvy shape, her giving no inkling of her pregnancy, revealed just days later at the VMAs.
Magazines have been criticised for over-modifying photographs, often without the subject's permission or knowledge.
Grazia magazine came under fire for slimming the Duchess of Cambridge's waist 'inadvertently' while Photoshopping her right arm to produce the cover image for the commemorative Royal wedding special issue on May 9.
Behind-the-scenes: A film from the shoot shows the star's figure in its more usual, and famous, curvaceous form
Bootylicious: Beyoncé performed in August, her thighs a healthy and more typical size than those on the cover of Harper's Bazaar
As comical as some Photoshop fails may be, the culture of digitally altering images is said to be part of a more sinister problem.
Seth and Eva Matlins, founders of magazine and
fashion label Off Our Chests, recently launched a campaign to pass a bill that would regulate the digital retouching of models in magazines and advertisements.
They want commercials and magazine spreads to
be accompanied by disclaimers if models have been significantly airbrushed or
Mrs Matlins said: 'Real, serious, and enduring problems occur when
we don't recognize that the images and ideals of the human form being presented
in the media are setting unrealistic expectations and standards for our
country's female population.'
In June, the American Medical Association spoke out against the use of photo-editing software, claiming that its altered images can have a negative impact on the self-esteem of children and teenagers.
The group said: 'We must stop exposing impressionable children and teenagers to advertisements portraying models with body types only attainable with the help of photo editing software.'
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About this font family
Linotype Sangue is part of the Take Type Library, selected from the contestants of Linotype's International Digital Type Design Contests of 1994 and 1997. This prize-winning font was designed by the German artist Gabriele Laubinger. The most distinguishing characteristic of Linotype Sangue is the contrast between the wide, rounded capital letters and the tall, narrow and pointed lower case. Another factor which makes this font so unique is the way Laubinger worked with stroke contrasts, using heavy strokes in the top third of the characters and diminishing to extremely light strokes at the bottom. Linotype Sangue makes a mysterious, secretive impression. It is best used for headlines and displays and shorters texts with point sizes of 12 and larger.
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Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
Award Information
Small Business Information
KORONIS BIOMEDICAL TECHNOLOGIES CORPORATION, 6901 E. Fish Lake Road, Maple Grove, MN, 55369
Principal Investigator:
() -
Business Contact:
(612) 730-1091
Research Institution:
AbstractDESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop a navigation system for ultra-thin bronchoscopes using advanced thin-film magnetic sensor technology. Recent technological innovations in the semicondu ctor processing industry make this program technically achievable at this time. The use of advanced magnetic-based localization technology to provide real-time navigation imaging without fluoroscopic guidance is highly desirable. Such a localization system in an ultra-thin bronchoscope allows an operator to navigate within the periphery of the lung and track the path of a biopsy tool as it approaches a peripheral lesion. PUBLIC HEALTH RELEVANCE: The proposed project relates to the navigation of ultra-thin b ronchoscopes. More than 150,000 solitary pulmonary nodules are reported annually in the US, each of which may indicate the presence of lung cancer. Bronchoscopy is used to locate anomalies in a patient's bronchus and if necessary, take a biopsy. Over 3,000 ,000 bronchoscopies are performed annually worldwide. The majority of target lung lesions are located in the peripheral areas of the lungs where large bronchoscopes cannot reach.
* information listed above is at the time of submission.
An Official Website of the United States Government


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[Watch] Here's What Happens When Your Side Chick Crashes Your Wedding
It's a scene out of a Tyler Perry movie.
The 2011 BET Awards nominations were announced yesterday, and Keyshia Cole fans may have noticed that she was absent from the list, despite the release of her fourth album, Calling All Hearts, last December. Looks like Keyshia noticed, too, judging from her tweets last night: "All u guys say BET didn't set me up for any nominations? its like this. Been on the scene 7 years. I was 21 when I got signed. 7 # 1 records. No awards 4 none of them/still touring. It is Wht it is."
She continued, "These types of thing R the way they R. I'm not upset about any of it in any way. I hope everyone that goes has a wonderful time."
Then today, she wrote, "That awkward moment when u realize in everyone's eyes your not the s--t anymore. #POW. I've officially got the memo. Thank mtv/bet."
Cole's show, Keyshia Cole: The Way it Is, has aired on BET for three seasons. Click here to see a full list of the BET Award nominees and vote for the Coca-Cola Viewers' Choice Award.
(Photo: Sean Gardner/Getty Images)
It's a scene out of a Tyler Perry movie.
A few fellow students have taken to Instagram displaying an appalling lack of remorse


text:
Welcome to the Grand Comics Database!
We're a nonprofit, internet-based organization of international volunteers dedicated to building a database covering all printed comics throughout the world, and we're glad you're here! Give our search a try, or take a look at the menu to the left to see how you can help us improve the site.
Don't forget to check out our newest feature, my.comics.org which provides a comic collection functionality and is, of course, based on our extensive database of international comics. We are are continuing to develop new features, so give it a try and let us know what you think.
600,000 covers uploaded!
Indexing milestone: La Novela Policiaca #2259 is our 600,000th uploaded cover on the site! Thanks to uploader Steve, and to all the uploaders who preceded him and continue to contribute.
GCD Comics Timeline
In the GCD — http://ow.ly/rxmC302xOcL
(The cover of MISTER MIRACLE #26, April 1991, was drawn by Joe Phillips, inked by Karl Story, and colored by Helen Vesik.)
At Wikipedia — https://en.wikipedia.org/wiki/Virgil_Finlay
In the GCD — http://ow.ly/U1nP302wTP6
(On the cover of "Real Fact Comics" #8, May-June 1947, the bottom panel is from the Tommy Tomorrow story drawn by Finlay.)
At Wikipedia — https://en.wikipedia.org/wiki/Dale_Keown
At Comiclopedia — https://www.lambiek.net/artists/k/keown_dale.htm
In the GCD — http://ow.ly/5Rtb302wT6F
At Wikipedia — https://en.wikipedia.org/wiki/Mike_Vosburg
At Comiclopedia — https://www.lambiek.net/artists/v/vosburg_mike.htm
In the GCD — http://ow.ly/2BjJ302wSOw
Bodé won the 1969 Best Fan Artist Hugo at the science fiction WorldCon, in St. Louis, USA that year. In 1974 he won the Yellow Kid Award at the Lucca comics festival in Italy. He was inducted into the Will Eisner Award Hall of Fame for comics artists in 2006.
At Wikipedia — https://en.wikipedia.org/wiki/Vaughn_Bod%C4%93
At Comiclopedia — https://www.lambiek.net/artists/b/bode.htm
In the GCD — http://ow.ly/Ilqq302ut5W (some explicit covers)
In the GCD — http://ow.ly/Srpw302uq8j
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At Comiclopedia — https://www.lambiek.net/artists/f/ferioli_cesar.htm
At Wikipedia — https://en.wikipedia.org/wiki/C%C3%A9sar_Ferioli
In the GCD — http://ow.ly/pQl9302uoRq
How to help ?There are several ways in which you can help us to improve our site and its content.
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Sweet Potato Soup
Total Time
Prep 20 mins
Cook 40 mins
Freezes well. NOTE Do not substitute green peppers for the red or yellow - you will get a very strange color. I prefer Vegetable broth but the data base does not have info on it.
Ingredients Nutrition
- 28 ounces low sodium chicken broth
- 2 lbs sweet potatoes, scrub trim and slice 1/2 inch thick
- 2 sweet bell peppers, yellow and red
- 1 dash cayenne pepper
- 2 garlic cloves, minced
- 1⁄2 teaspoon dried thyme
- 1⁄4 cup buttermilk (optional)
- pepper, to taste
- sour cream (optional)
- Bring broth to a boil in saucepan;add sweet potatoes; cover and immer until tender, about 15 minutes.
- Stem, seed and couarsly chop peppers; add to sweet potatoes as you prepare them; add garlic and thyme and stir.
- When mixture is tender blend until smooth.
- Freeze in individual servings if desired.
- Thin with buttermilk, mil or water to consistency you prefer.
- Top with pepper and a dollop of sour cream if you like.


text:
Need news to move volume and price. Just hope this Mgmt team puts out the needed press in the future. Some companies don't and its like watching paint dry.
If they can get some other Pharma companys to partner with them on there products to prolong Patents and develop new Patents with partnerships this will become a very good company . I think this is the reason Dr. Frost likes this co. and he has a lot of contacts in the Pharma field .
Sentiment: Strong Buy
Dr. Frost is very very occupied with OPK, I really think this stock is on the back back burner with him. I do believe that Mgmt from Alliqua knows that he is invested and their performance could bring them on the front burner and line their pockects for life. The need to show their talents first.


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Alcario Juarez
Alcario Juarez, 71, of Lockhart, Texas passed away on July 19, 2016. Visitation Friday, July 22, 4 to 7 p.m., with Rosary at 7 p.m., St. Mary's Catholic Church. Mass Saturday, July 23, 23, 1 p.m., St. Mary's Catholic Church, Lockhart. Burial St. Mary's Cemetery.
Arrangements by McCurdy Funeral Home, Lockhart, Texas, 512-398-4791, www.mccurdyfuneralhome.com.


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Elliot Abrams tears BHO to shreds over Syria:
In March 2011, President Obama committed the United States to action in Libya that involved roughly 100 cruise missile firings, 12 U.S. Navy ships in the Mediterranean, and 75 U.S. Air Force and Navy aircraft including B-2 bombers. And the Libyan case involved no use of chemical warfare by Muammar Qadhafi. Still, the president saw no reason to seek a congressional vote.
This context makes his claim that he must seek a vote now, in the Syrian case, unintelligible. It cannot be a matter of principle, or the principle would have applied to intervention in Libya as well. From all appearances, the president either lost his nerve, or more likely read opinion polls suggesting that intervention would be widely unpopular. He came to this decision abruptly, after sending out his new secretary of state to make two powerful, emotional, and affecting war speeches that explained why we must act. And he came to this decision, by all accounts now appearing in the press, without even consulting Secretary of State John Kerry, relying instead on his mostly young and comparatively inexperienced White House staff.
This erratic conduct leaves U.S. foreign policy in a shambles. A few examples should suffice. Who, in Jerusalem or Tehran, will now believe that "all options are on the table" and that the president might really use military force to prevent Iran from acquiring nuclear weapons? Which neighbor of China, facing that nation's rising military power and hoping for America to offset it, will now believe that the "pivot to Asia" has any real military content? Who in Moscow or Beijing will now think this president is a leader who must be feared?
"Principle" in this administration? Really?
the marxist voted PRESENT 77 times as a senator,,,,,,he cant make a decision except if its about race....
if only he had a Son..Im sure he would look just like Travon....but NOT the 175 other Black Teens who committed Murders this past year against White babies, children, men/women and little old WWII vets!
Nope the ROPE a DOPE will not speak to that CRIME amongst his own people!! He will not BITE the hand that feeds him....nope he will not tell the TRUTH!
and he won't make a decision without someone else who can be the fall guy in case things go wrong. With respect to a possible attack on Syria, there's no fall guy available... hence BHO doesn't want to attack anymore.
Putin must be having a field day, having made BHO look like a fool regarding Edward Snowden, and now the Syria debacle.


text:
Allergies Health Center
Allergy Diagnosis: Questions Your Doctor Will Ask
In this article
The first thing your doctor will do is talk to you. He'll examine you and ask questions about your symptoms and your family's history of allergies, such as:
- What kinds of symptoms do you have?
- How long have you had them?
- When your symptoms happen, how long do they last?
- Do your symptoms come and go throughout the year, or do they last year-round?
- Do your symptoms hit when you're outdoors, or indoors -- like when you clean your home?
- Do they get worse when you're around pets? Do you have any pets?
- Do you smoke? Does anyone in your family smoke?
- Do your symptoms keep you from doing things, or from sleeping at night?
- What makes your symptoms better? What types of treatments have you tried?
- What allergy drugs are you taking now? Do they help?
- What other medications are you taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements?
- What kind of heating system do you have? Do you have central air conditioning?
- Do you have any other health conditions, like asthma or high blood pressure?
- Do you have problems with your sense of smell or taste?
- Do you get better on the weekend and worse when you go back to work?
Your doctor could send you to a board-certified allergist who specializes in diagnosing and treating allergies, or he might suggest medication. An allergist will run tests to find out exactly what you're allergic to, so together you can create the right treatment plan.
Recommended Related to Allergies
Wondering if your nagging cold is actually an allergy? Or what about your new skin cream that made your hands break out? Distinguishing an allergy from a non-allergic condition is not always a clear-cut task. But knowing the difference can sometimes help you solve what's ailing you, which in turn could mean faster relief. Mary Fields knows just how difficult pinpointing an allergy can be. The 64-year-old Bronx resident tells WebMD she was convinced her frequent hives were caused by something in...
Read the Could It Be an Allergy? article > >
Questions for Your Doctor
You get to ask questions, too. Start with these.
- What's causing my allergies?
- What symptoms should I be concerned about? When should I call your office?
- What allergy medications or other treatments are available? What are the benefits and side effects of each?
- Will I need allergy shots?
- Should I take medicine all the time or only when my symptoms get worse?
- Should I stop outdoor exercise?
- What types of plants are best to put in my yard?
- What can I do around my home to get fewer symptoms?
- What can I do to have fewer symptoms when I go outside?
- How can I tell the difference between allergies and a cold or the flu?
- Will changing my diet help?
- How often should I come in for follow-up appointments?
WebMD Medical Reference
Today on WebMD
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text:
I have an application with a popup menu. I'd like to use the popup in the usual way (i.e., it should appear when the user right-clicks anywhere in the window), but I'd also like to attach it to the main MenuBar at the top of the window. I'm not sure how to do this.
I'd thought it would as simple as calling myJMenuBar.add(myPopupMenu) but this doesn't work.
JMenuBar.add() wants a JMenu parameter, not a JPopupMenu.
Does anyone have any suggestions?


text:
Most Recent Articles In Designer and Luxury
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The Hervé Léger by Max Azria retail network is growing.
This story first appeared in the August 28, 2009 issue of WWD. Subscribe Today.
BCBG Max Azria Group is expanding the label's reach with store openings in London, Singapore and Dallas, and a relocation of its Madison Avenue unit in Manhattan.
Max Azria, designer and chief executive officer, said the recession presented opportunities for growth.
"With the downturn comes momentum," Azria said. "The real estate becomes affordable, and the retail math becomes more logical for us according to our business formula." In addition, he said the popularity and loyal customer base of Hervé Léger by Max Azria make retail growth "natural and necessary."
The London store, which is to open on Sept. 17, just before fashion week kicks off in the British capital, will be the label's largest in the world. The 1,745-square-foot boutique, at 29 Lowndes Street in the upscale Knightsbridge area, is split into two levels: a 560-square-foot main floor, and a 1,185-square-foot lower level that features a VIP area.
"We tested the U.K. market with Hervé Léger by Max Azria at Harrods and Selfridges," Azria said. "Our sell-through has been in the double digits per week, and in regards to Harrods in, particular, our business has tripled from year to year."
Azria declined to disclose sales projections for the new unit.
The Los Angeles-based company is bringing Hervé Léger by Max Azria to Singapore next month, when it will open a 1,000- square-foot boutique at the ION Mall, followed next March by a 1,080-square-foot store at the Marina Bay Sands Resort & Casino.
In the U.S., the company plans to open a 1,323-square-foot Hervé Léger by Max Azria boutique in Dallas' NorthPark Center in October. The brand next month will relocate its Madison Avenue boutique from 744 Madison Avenue to a 1,377-square-foot space at 804 Madison Avenue. "Our lease was up at the old location, and we found an ideal space," Azria said.
The Hervé Léger by Max Azria brand is wholesaled to stores such as Bergdorf Goodman, Saks Fifth Avenue, Nordstrom and Intermix. Since Azria relaunched the label in 2007, it has become a favorite of celebrities. Rihanna, Kylie Minogue, Kate Bosworth, Diane Kruger and Beyoncé Knowles have worn looks.
Azria said he hopes for more expansion in the U.S. and sees freestanding retail opportunities in markets such as Canada, Scandinavia, Italy, and the Middle East, specifically Dubai, Lebanon and Kuwait.
As for the BCBG Azria Group's overall strategy, Azria said there is more retail growth in the pipelines. "Retail expansion for all our brands, including Hervé Léger by Max Azria and BCBG Max Azria, will continue to be an important focus for us," he said. "We look forward to expanding our presence throughout North America, Europe, the Middle East and Asia."


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The Invisible Woman Premium06 February 2014 | by Francine Stock | Comments: 0
CinemaA costume drama about a love affair between the Victorian literary superstar Charles Dickens and a little-known actress raises certain expectations. There will be strictures and conventions, agonised looks and perhaps a deathbed scene. There will be the suggestion of perfect union or understanding despite the pressures of celebrity, a film à clef perhaps to one of the more famous novels, something attuned to twenty-first-century notions of romance. This will perhaps be the Secret Love of The Man Who Wrote Great Expectations. Then again, this is a film directed by Ralph Fiennes, who also plays Dickens and, as his debut feature, Coriolanus, demonstrated, has a rare skill for the two-handed trick of actor/director and a tendency to temper passion with intellect. The Invisible Wo ....... ....... ........ ........ ........ ........ ........ ........ ........ ........ ........
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Madison, WIUSA
Hometown: Seattle
March 12, 2013
I find that since I can be a bit shy verbally, I find it much easier to connect with others through touch. When it comes to *who* to touch, it really depends on how I feel about the person I'm interacting with - generally it's summed up by two questions: "Are they spiffy?" and "Do they seem responsive to touch?"
Absolutely! At times there's no verbal response, just an immediate hug ;P
I don't remember a time when it hasn't been the case!
Well, I've been to a few already back in[masked], but took some time away. Now I'm back :)
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Researchers Now Have a Myriad of...
Loss of Lives in Clinical Trials...
Keep the Opportunities, Lose the Opportunists
Clinical-Style Validation, Regulation, and Quality Control...
Flow cytometry is and always has been a multiparametric technology. Increasingly simultaneous and correlated measurements can be used to provide greater detail about the phenotype of cellular subpopulations. Clinical laboratories now routinely employ 5- or 6-color flow cytometry, while research labs are experimenting with 10- to 20-color capabilities.
Innovations such as image flow cytometry and acoustically focused flow cytometry have added new dimensions and capabilities, and in some cases flow cytometers have begun to replace other instruments like microscopes.
At the same time, in order to reach its full potential, the field of flow cytometry must overcome some significant challenges. Chief among these is the abundance of data generated from increasingly large multiparametric analyses.
At the other end of the spectrum, there are some basic problems that are still being solved, such as how to accurately calculate the sensitivity of the instrument. Potential solutions to a range of problems impeding the efficient use of flow cytometry were presented at the recent "Great Lakes International Imaging and Flow Cytometry Association" conference.
Many flow cytometer sensitivity measurements do not accurately represent the sensitivity of the instrument, according to Eric Chase, president and CEO of Cytek Development. Typically, detection limits are used to describe instrument sensitivity, equating the noise of the instrument to the mean equivalent fluorochrome (MEFL) value, which is the number of dye molecules the instrument can supposedly detect.
"That number is kind of meaningless," according to Chase, because the detection limit is not really a function of the performance or optical sensitivity of the cytometer. It's more a function of the design of the electronics.
"In newer flow cytometers, the way the electronics work, that number should always be zero because the newer digital flow cytometers use area systems," Chase added. "They give a detection limit of zero."
That doesn't mean, however, that the instrument can pick out one or two dye molecules from background noise, which is the kind of information intended to be conveyed by a sensitivity rating.
Chase said that manufacturers continue to use detection limits because the numbers are low and it makes the instrument seem sensitive. A typical detection limit would be 100 dye molecules or less.
Chase's method is based on values called Q and b that describe flow cytometer performance. Q is related to the ability of the instrument to capture signals, and b is a measurement of the background of the instrument. Although BD Biosciences adopted Chase's method in its cytometer quality-control package, he says that the Q and b of the instrument do not give information that is directly actionable in the laboratory.
He described how Q and b could be used to calculate a resolution limit, analogous to MEFL, but that describes how many molecules of dye a user needs to be fully resolved from the background noise.
This is one step away from the number of antibody-binding sites on a cell that the instrument can detect, he explained. Users can calculate their own resolution limit based on their instrument's Q and b values, but more support from instrument and reagent vendors would be necessary for determining the number of antibody sites an instrument could resolve.
Chase foresees a future where resolution limits will be industry standard and every reagent bottle will come labeled with the necessary information for making the calculation. This would represent a major advantage to the user, but first users and vendors alike will have to let go of their attachment to superlow—but not necessarily accurate—detection limits.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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DRAKE ~ JUNGLE from OctobersVeryOwn on Vimeo. Drake drops a short film called "Jungle." There is also talk of a mixtape on the way.
Category - Lifestyle
Grace Bol for W Magazine February 2015 by Marko MacPherson – See more at:
Kanye West and Adidas will officially announce their new line next week, for now check out images of the "Yeezy Boost."
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T.I. drops a mini movie with Jeezy & Watch The Duck for "G' Shit" off of "Paperwork.
Rihanna Covers Harper's Bazaar US March 2015 by Norman Jean Roy
Are you reading to see what all the fuss is about? Well, soon you will. Ye plans to shut down NY Fashion Week to stir up some buzz about his Adidas Collaboration. This hight anticipated reveal will be supported by the new "Confirmed" app...


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Welcome to FindLaw's searchable database of District of Columbia Court of Appeals. decisions since January 1997. FindLaw offers a free RSS feed for this court. We also maintain an archive of Opinion Summaries from September 2000 to the Present. Cases are browsable by date and searchable by docket number, case title, and full text.
Federal Courts
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|Docket #
|MARSDEN v. DISTRICT OF COLUMBIA
|July 14, 2016
|No. 15–CV–1068.
|ROBINSON v. UNITED STATES
|July 14, 2016
|No. 13–CF–1283.
|SMITH v. UNITED STATES
|July 7, 2016
|Nos. 15–CM–342, 15–CT–343.
|FALCONI SACHS v. LPF SENATE SQUARE LLC
|July 7, 2016
|No. 14–CV–433.
|DEAN INC v. DISTRICT OF COLUMBIA DEPARTMENT OF EMPLOYMENT SERVICES
|July 7, 2016
|No. 14–AA–1141.
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Ratings based on 31,550 Guest Reviews
Hear it directly from our travelers
3.6 Room cleanliness
3.5 Service & staff
3.5 Room comfort
3.2 Hotel condition
TRAVELOCITY GUEST REVIEWSHear it directly from our travelers
by A traveler
Nice hotel overcrowded teen and preteen customersPosted Jul 25, 2016
Teen visitors unsupervised and out of control. booking through Travelocity was a joke! It took us an hour to get out reservation confirmed at hotel. They had no record.
by A traveler from San Diego
Nice hotel, very nice large rooms, good buffet...Posted Jul 11, 2016
Pros: ..the room...parking lots...
Cons: ...carpeting...
Location: ...right on the Strip, excellent location to start walking on the Strip...
Very pleasent stay, very comfortable room, large, king bed, main tower...
by A traveler from victorville, CA
Good price bad servicePosted Jul 10, 2016
My room did not lock so I called the front desk informed them what was going on. They told me they were going to send a technician after 5 hours and no one showing up I went to the front desk well they informed they had no technician available so they gave me another room with one bed and I needed to after almost 3 hours they took a rolling bed. I think you should have more staff so you can expedite the orders that way we don't have to wait for hours to have a service done
by A traveler
Nice hotel for te kidsPosted Jul 4, 2016
If traveling with kids this would be the ideal hotel to stay at.
by A traveler from cali
Location is okPosted Jun 29, 2016
Nice Room Very clean room and big Ac little bit too noisy
by A traveler
Posted Jun 26, 2016
If you go with your kids this is a great hotel to stay.
Comment from Hotel Management
Jun 27, 2016 by Jessica , Hotel Management
We are so very happy to hear about your excellent vacation you recently had with us. We are delighted you enjoyed every bit of your time with us and got to experience all that we have to offer. We look forward to seeing you again soon. Have a wonderful day!
by A traveler from phoenix, az
Family vacationPosted Jun 25, 2016
We booked with circus circus because we knew our 3 kids would enjoy the amusement park, and midway while we would do our adult things. My husband, and I ended up having so much fun doing things with them, we never made it to the casino :) I guess we will have to plan another trip
Comment from Hotel Management
Jun 27, 2016 by Jessica , Hotel Management
We are so very happy to hear about your excellent vacation you recently had with us. We are delighted you enjoyed every bit of your time with us and got to experience all that we have to offer. We look forward to seeing you again soon. Have a wonderful day!
by A traveler from Las Vegas
A upgrade for the upgradePosted Jun 24, 2016
Pros: the price is just right
Cons: hard to tell so far because it is only my second stay
Location: This location has lots to offer CVS nearby McDonalds next door. and several other places to eat with in the property.
The last time I stayed here was a complete disaster as some have may read. So I figured I would rate them one more time and here is my findings and recommendations to you, Stay here but insist on the TOWER ROOMS. These rooms compared to the non connected rooms are far more better as well as convent to the downstairs activities. This time I was upgraded to a king size tower room with a view of Summerland, it was the handicapped room but it is still a upgrade from my last visit. Staff this time knew where I was going and how to send me. I used the bellman service this time checking out and besides being a half hr behind the quoted time al went great.
by A traveler from Grand Junction CO
Not what I expectedPosted Jun 21, 2016
Pros: First stay was acceptable, clean, convenient, and friendly. But this second stay not at all =[
Cons: Clarity in reservation over what I was getting. 2X cost for FAR less than 1/2 value from previous is not acceptable consistency for this customer
Location: a walk to the fun areas of the strip, but basically has everything within for gamblers and family fun if you dont want to bother exploring
As a way station tourist stop to and from California, our first stay was comfortable, convenient enough, price was AWESOME, so even though my hotel manager friend (different resort) was lukewarm, I thought I'd give it a shot. Definitely lived up to its name (NOT the place for non-crowd folks) but ok enough that I booked for the return trip 7 days later because I knew what to expect. But apparently I didn't. The price was more than DOUBLE (I'd gotten an amazing deal the first time).Though I called to ensure late arrival as we were not in town til 1am (told no problem), we arrived to be told the 2 queens I'd reserved were not available but I could have a king and a rollaway. I reminded them of my reservation & call, and suddenly 2 queens WERE available. The room however was in the motel section (didn't really know they even had one) and it was "first come first served" for arrivals. An older room in a distant part of the resort, it was hot but clean. Turned on the a/c and within about 2 minutes it turned off. Apparently it was set to cycle, and eventually it did come on and off all night again, sadly cooled the room and we tried to sleep uncomfortably at about 80-85 degrees. Woke in the morning to the neighboring TV and conversations in other rooms through the thin walls. Could have called desk but tried to suck it up. Totally negated the first stay experience, my yay went to nay in a hurry. FAR too inconsistent amenities to count on, doubt I will return.
by A traveler from Arizona
No housekeepingPosted Jun 20, 2016
Too far awsy from Las Vegas Strip. Hotel swell was muggy. Room Service qas slow! Requested towels and arrival time was terrible. Coffee and ice bucket were inside restroom. Ugg!


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|Showing 1-1 of 1 reviews
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| 3 of 4 people found the following review helpful:
Great Bag! - Aug 10, 2011
Player: Pac Pro (Pac NW)
I had a original Under Armour bag for almost 6 years and decided to replace it with this one. It seems to have more rooms and more compartment but I have to take one star off due to each side compartments only has one zipper. If you are used to using two, you know what I mean by only has a ONE zipper.
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Cast: Jeetendra, Mehmood, Nanda, Nazir Hussain, Om Prakash Music Director: Ravi Director: Narendra Suri Producer: Archana Films Lyrics: Rajinder Kishan Year: 1969 Genre: Hindi
Language: Hindi
Status: Released
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Crazy Substitute Teachers
Enjoy, NG4.03 / 5.00 2,613 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner4.01 / 5.00 2,887 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.97 / 5.00 7,386 Views
Great animation, great everything basically. Especially loved the Gold Digger bit, almost started crying at that point.
It's the best from the best
a very good one from this series
i laughed real hard!
i cried laughing at the gold digger part, man that song iz terrible!
on scooter. HAHAHA! the punks shirt: WILL CATCH CHEESE FOR CHEESE lol.
he looked funny
when he saw you can get a free car


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The Netherlands is the main "constituent country" of the Kingdom of the Netherlands. It is a small, densely populated country located in the western European Union with three island territories in the Caribbean. The European part of the Netherlands borders Germany to the east, Belgium to the south, and the North Sea to the northwest, sharing maritime borders with Belgium, the United Kingdom and Germany. The largest and most important cities in the Netherlands are Amsterdam, The Hague and Rotterdam. Amsterdam is the country's capital, while The Hague holds the Dutch seat of government and parliament. The port of Rotterdam is the largest port in Europe – as large as the next three largest combined – and was the world's largest port between 1962 and 2004. "Netherlands" literally means "Lower Countries", influenced by its low land and flat geography, with only about 50% of its land exceeding one metre above sea level.
A – B – C – D – E – F – G – H – I – J – K – L – M – N – O – P – Q – R – S – T – U – V – W – X – Y – Z – See also – External links
- The best thing out of Maastricht is Andre Rieu.
- Louise Burfitt-Dons, January 2013 in a speech promoting her candidacy to represent London in the EU as an MEP for the British Conservative Party
- Now, van Bronckhorst with pace! Oh, it is an absolute firecracker from Giovanni van Bronckhorst! One, nil! Holland!
- Ian Darke, Uruguay v. Netherlands (6 July 2010), 2010 FIFA World Cup (2010), South Africa.
- It is true that if you simply have market capitalism not embedded in a true democratic system, then you will get increasing inequality... And that is why every modern capitalist system has a welfare state and in Europe these welfare states consume 50 percent of GDP, redistribute it in fairer ways. I have always thought the European Union represented a truer embodiment of what I would regard as something like the end of history... The United States' model is a little bit more liberal and therefore we do less redistribution than, let's say, Holland or Sweden, but all modern states do that.
- Francis Fukuyama, as quoted in "Fukuyama: 'Putinism', Radical Islam No Alternative To Liberal Democracy" (30 January 2016), by *Charles Recknagel, Radio Free Europe: Radio Liberty.
- I love being in Amsterdam
- Prince David Osei, quoted on Ghana Web (February 15, 2016), "Photos: Prince David Osei storms Netherlands, premiers movies"
- They [politicians] are not interested in the interests of the Dutch citizen and are working along on the transformation of The Netherlands into Netherabia as a province of the Islamic superstate Eurabia.
- Geert Wilders, De Volkskrant (8 August 2007).
- Islam is the Trojan Horse in Europe. If we do not stop Islamification now, Eurabia and Netherabia will just be a matter of time. One century ago, there were approximately 50 Muslims in the Netherlands. Today, there are about 1 million Muslims in this country. Where will it end? We are heading for the end of European and Dutch civilisation as we know it.
- Geert Wilders, "Mr Wilderss contribution to the parliamentary debate on Islamic activism". Speech before the Dutch Parliament (Internet Archive). 2007-09-06.
- The more dominant the Islamic culture in The Netherlands will be, the more distant we will become from anything that has to do with freedom, tolerance and equality. Because the Islam – in contrast with other religions – will not accept anything else but the Islam. The society will change for the worse. It is no 'clash of civilisations', but a collision between culture and barbarism and retardedness.
- Geert Wilders, 'Geert Wilders in interview Nu.nl, 11 September 2008.
- The Dutch example shows that when people overcome their fear, David can defeat Goliath.
- Geert Wilders, Marked for Death: Islam's War Against the West and Me (May 2012), Ch. 13: "How to Turn the Tide", p. 208


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Shaun Brown♥ -
Shaun BrownNews -
Something very awesome happened today. I can't say anything more about it (for now) but I can finally talk about this other awesome thing that I'm super excited to be part of! In the upcoming Firefly Online game, I get to be the voice of the male avatar!!…
Shaun BrownMovies -
HBO's Last Week Tonight with John Oliver has quickly become the source of endless viral videos on the internet.
Read more at http://furiousfanboys.com/2014/11/video-jj-abrams-and-r2-appear-on-the-force-awakens-set/
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One of the longest running and most respected film fansites
5, 4, 3, 2, 1... Thunderbirds Are Go! as ITV remake launches with a bang...
No strings attached for new TV series as it debuts in Cannes, blending computer animation with live-action models. By Stuart Dredge
Alex Welch
Hello Schmoeville! Your old pal Kristian here! So I was checking my email the other day and an email came in from Disney inviting Mark and I
iTWire - iiNet breaks ranks over piracy
Australia's second biggest ISP, iiNet, has broken ranks with other ISPs and refused to join their calls for a graduated response scheme to b
Piracy policy could sully Australia's image
Comment | In a bid to make ISPs do more to address online piracy, the government has proposed a legislative solution that would have uninten
Alex Welch
By Alex Welch Hey Schmoeville This is.... this sucks Schmoeville. It really really... is just the worst. Something that comes out of the blu
Android grabs record 85 percent smartphone share
Large-screen iPhones could pose a threat to Google's dominance, said Strategy Analytics
Victim tells Royal Commission of abuse at Riverview
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Nismo GT-R Bound For 2014 Bathurst 12 Hour, Rick Kelly At The Helm
Legendary tuning house Nismo will field a GT3-spec GT-R in next year's Bathurst 12 Hour, with a team led by Nissan V8 Supercar driver Rick K
Marco Lys - Be Rich (Bazu Remix) (Ministry of Sound TV)
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The revolution is over: the rude mobile phone users have won
Marina Hyde: The unashamed use of mobile phones in public places means there is little left to do but offer a resigned shrug
DJ Fresh Vs Diplo ft Dominique Young Unique - Earthquake (WestFunk &...
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♫ Flume Insane ft. Moon Holiday ♫
Absolute beauty :) Flume are sooo good :)
Discovery could boost Internet bandwidth
(AFP) – 2 hours ago. WASHINGTON — A new fiber optic technology could increase Internet bandwidth capacity by sending data along light beams
Trance Remember Mix Part 2 by Traxmaniak
All my "TRANCE REMEMBER MIXES" now in MP3 : http://traxmaniak.blogspot.ch ____________________________________________ .:::: TRACKLIST ::::.
Man of Steel - "Fate of Your Planet" Official Trailer [HD]
http://manofsteel.com http://www.facebook.com/manofsteel Get tickets now: http://bit.ly/MOStickets In theaters June 14th. From Warner Bros.
Fans Loving the Austin 400
Fans have flocked to Texas to see the V8 Supercars' inaugural Austin 400 – Australians and Americans have flooded into the Circuit of the Am
Newt Gingrich Meets the Smartphone (Annotated Edition)
Newt Gingrich Meets the Smartphone (Annotated Edition)


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Impressively, perfectly! L&FV With pleasure we invite you in group.
Arches in Nature Sincerely, Vasiliy from Siberia.
Muy bonito
Scored a great shot. Frame it and hang it up.
Wonderful lighthouse & capture. Many greetings from Athens.
Much more technically dificult that Everest.
Nobody's ever suceced climbing it in winter. [probably impossible]
Very beautiful thing.
Where is this wonderful Oak Tree. Gorgeous photo
Przepiękne! Niewiarygodne co człowiek potrafi zbudować. Pozdrowienia z Polski!
like firefly's of the sea, it is magnetic and serene!
Excellent Picture!!!


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Rebels Shell Damascus University: 15 Students Killed
White House 'Deeply Concerned' by Attack
A mortar attack by an as-yet-unidentified group of rebels have shelled Damascus University today, killing 15 people and wounding a number of others at the university cafeteria.
The university was likely not the intended target for the attack. Rather, it is located in central Damascus, not far from the Defense Ministry and President Bashar Assad's official residence, either of which would be something rebels would be eager to hit.
The White House issued a statement expressing "deep concern" for the attack, but insisting they weren't clear if rebels were responsible. They urged both sides to "abide by international law," which would ban attacking a university full of civilians.
Yesterday, officials from unnamed Arab League nations reported that the growing amount of weaponry being given to Syrian rebels is a prelude to a rebel offensive against the capital. Today's incident underscores how dangerous such clashes in areas still packed with civilians can be, something that has been seen in other cities as well, where locals either didn't, or couldn't, flee an oncoming attack and ended up trapped in the middle of it.
Last 5 posts by Jason Ditz
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- Russia DM: More Forces Deployed in Crimea, Northern Caucasus as NATO Approaches - July 27th, 2016
- Turkey's Interior Ministry: Over 15,000 Detained Following Coup - July 27th, 2016
- Turkey: 1.5% of the Military Participated in Failed Coup - July 27th, 2016
- Turkey Turns Ever-Growing Purge Against Press, Over 100 Outlets Shut - July 27th, 2016


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Conshohocken, PAUSA
Hometown: Conshohocken
January 3, 2009
Jay Peak
12 years
No answer yet
Ever since Bull Mountain flipped over to Yuppieville, I've been looking for new places to ride. Sesh. Pow. Gnar.
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|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
Undisputed Champion
Join Date: Apr 2011
Posts: 1,630
Quoted: 2 Post(s)
Rep Power: 9
Points: 25,909.54
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Total Points: 14,282,918,612.09
Boxing on CBS gets 1.8 million viewers
That's up from the early estimates of 1.4 million. Remember previously the rating was said to be okay for the timeslot coming second behind the basketball game. Now this would upgrade would probably make it the most watched sporting event in that time slot.
Basically a boxing match that was nothing more than a prelim for a showtime event with zero promotion showcasing a bantamweight managed to get higher ratings than every other sport in that timeslot.
I read the Butler game was the highest rated in that spot all year. Boxing either beat it now or got second.
Dan Rafael @danrafaelespn
Final viewership figures are in for last week's return of #boxing to CBS. Santa Cruz's bout averaged 1.794M viewers. That's pretty damn good
All Men Must Die
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Imagine if the main event was shown on CBS, ratings would have been massive
Avy King 2007-2013
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I pay attention to boxing and literally had no clue this event even happened lol. Whoopsies.
Join Date: Apr 2011
Location: Los Angeles
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I overslept and missed it... glad it did good numbers. Even though I heard Santa Cruz had a tough time
with some promotion and a real star like Canelo or Gatekeeper Cotto they would break records
The Money Team
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Total Points: 7,565,919,237,393,670.00
Too bad they only show crap fights, imagine a fight with the drama of a JMM-Pac fight being shown in regular networks for the average Joe to see? Boxing would be back on the mainstream!
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great news. im glad. hope it continues
Surrender Dorothy!
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Boxing is dead.
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The is very respectable Ratings especially without much Promotion for that Event or any Commercials
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90% of those were from the College hoops game(check the earlier article) that was being played so people tuned it, if there was just filler material or reruns before the boxing that number would be under 1m.
and before calling the number good, you need to look at the avg CBS viewership for that day and timeslot.
I still dont think 1.8m is good, for HBO its great but not for a over the air channel during mid saturday in mid winter so not many ppl outside.
The 5-7 timeslot has the second most viewers after the primetime slot
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I think Adamek-Cunningham II is on NBC in the daytime on Saturday. Their first fight was really good, the crowd was great. It had that old school east coast fight feel it reminded me of the fights that used to be on network TV, hopefully the rematch is the same.
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If you're a credit card issuer, a cell phone carrier or an airline you use IVR (interactive voice response) phone trees to resolve calls and avoid sending what you deem to be unnecessary calls to your call center. Live agents are expensive. But almost every consumer hates dealing with IVR systems. They're often frustrating, don't resolve issues and delay what consumers ultimately want, which is to talk to a live customer service agent.
Now comes a deliciously subversive "click to call" service called Bringo. You select the category and then the company you're trying to contact, enter your phone number and they'll connect the call when the service has bypassed the phone tree and reached a live agent.
I tried two calls: one to Sprint and a second to Chase (credit cards). Each took about 35 seconds to connect and I was connected to a live agent. One thing I didn't test is whether the agent was the right one for any particular issue since I was just testing the system and not actually calling with a problem. (Corporate reps would tell you IVR helps them route calls properly.)
This service would be especially valuable in a mobile context, when there's even less tolerance for waiting and phone trees. Regardless it seems to be effective in connecting calls to live agents.
And now to the inevitable: "what's the business model?" I didn't speak to company representatives so I don't know their plan. One could imagine (beyond AdSense) that advertisers might want to be in front of consumers with alternative offers (e.g., Verizon seeking to get Sprint users to switch, etc.). If there was enough traffic to the site there might be some monetization potential here.
Accordingly, I wanted to find out what the annual volumes were of customer service calls in the US but could not find it on Google, Yahoo or MSN and so I went to ask ChaCha's human guides but the site appears to be having technical problems and I couldn't get through to anyone . . .
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text:
, Volume 42, Issue 2, pp 221-243
First online:
Minimal algebras of infinite representation type with preprojective component
- Dieter HappelAffiliated withFakultät für Mathematik Universität Bielefeld
- , Dieter VossieckAffiliated withFakultät für Mathematik Universität Bielefeld
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Let A be a finite dimensional, basic and connected algebra (associative, with 1) over an algebraically closed field k. Denote by e1,...,en a complete set of primitive orthogonal idempotents in A and by Ai= A/AeiA. A is called a minimal algebra of infinite representation type provided A is itself of infinite representation type,whereas all Ai, 1≤i≤n,are of finite representation type. The main result gives the classification of the minimal algebras having a preprojective component in their Auslander-Reiten quiver. The classification is obtained by realizing that these algebras are essentially given by preprojective tilting modules over tame hereditary algebras.
Reference tools
- Title
- Minimal algebras of infinite representation type with preprojective component
- Journal
manuscripta mathematica
Volume 42, Issue 2-3 , pp 221-243
- Cover Date
- 1983-06
- Print ISSN
- 0025-2611
- Online ISSN
- 1432-1785
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Industry Sectors
- Authors
- Dieter Happel (1)
- Dieter Vossieck (1)
- Author Affiliations
- 1. Fakultät für Mathematik Universität Bielefeld, D 4800, Bielefeld 1, BR Deutschland


text: walgreens Attorney General Koster: Walgreen's Pricing Still Deceives Consumers By Associated Press • Sep 22, 2015 Charles Hathaway / Flickr Missouri's attorney general is taking Walgreen's back to court, saying they are violating a settlement reached last year over its pricing practices. Koster Reaches Accord With Walgreens Over Mismarked Prices By Jason Rosenbaum • Jun 5, 2014 Attorney General Chris Koster reached an agreement with Walgreens regarding overcharging consumers. Koster sued the pharmacy giant last year, contending that stores around the state were charging more than the prices displayed on shelves. His office's lawsuit stated that the company was violating the state's consumer-protection laws by "engaging in false, misleading and deceptive advertising and pricing schemes." Mo. Attorney General Accuses Walgreens Of 'Deceptive Pricing Schemes,' Files Lawsuit By Chris McDaniel • Aug 27, 2013 Updated 5:12 p.m. with comment from Walgreens. Missouri Attorney General Chris Koster is accusing Walgreens of engaging in false and deceptive pricing schemes, that he said amounts to stealing. In St. Louis Tuesday, Koster announced a lawsuit against the company. Koster had investigators go to stores across the state, and said they found display tags were often inaccurate, and that membership rewards didn't always deliver on the price reduction. Deadline nears for Express Scripts and Walgreens agreement on pharmacy rates acephotos1 / dreamstime This Saturday is the deadline for St. Louis-based Express Scripts and Walgreens to reach a deal on pharmacy drug rates. As Maria Altman reports from St. Louis,… if no agreement is reached… those who use Express Scripts will not be able to fill prescriptions at Walgreens in the New Year.


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Rarely in the medical literature does one find a book that fulfills its title and effectively reaches the reading audience for whom it is intended in such a succint, readable, learnable fashion as does this book.
The author's intent is to address topics of "practical medical humanism" oriented to the medical student, house officer, or young practitioner to "stimulate increased concern and questioning by physicians about these issues and to
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Featured Story4TH QUARTER JOHN DEERE AWARD RECIPIENTS
This award, in its twenty-fourth year, is for staff and students that have done an exceptional job and who have gone "above and beyond" the norm. Ten senior students are chosen for this award each quarter along with a staff or community member. The recipients are honored at an awards ceremony each quarter in the library and attended by parents,... [Read the complete story]
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Hotels in Jumeirah Beach
Search all hotels in Jumeirah Beach
Trending now in Dubai
- Most bookedBurj Al Arab
975 people looked at this hotel in the last hour
Most recent review
"A VERY expensive destination but worth the experience at least once if you can afford it. The staff are sensational. The rooms are huge. And the hotel has a range of in house activities available. Room service is not too dramatically expensive if you cannot afford to the dining rooms."
A Traveller, May 2016, AU
608 people looked at this hotel in the last hour
Most recent review
"This was the 5th time to this hotel. Spent a long bank holiday weekend, the staff were extremely helpful and the quality of service exceptional. "
A Traveller, May 2016, GB
497 people looked at this hotel in the last hour
Most recent review
"I stayed at the hotel for 4 days with my husband. We booked the Executive Club Room too which provided breakfast, afternoon tea and snacks and drinks in the evening. A very nice place to relax before heading out to Dubai for the evening. "
A Traveller, Jun 2016, GB
327 people looked at this hotel in the last hour
Most recent review
"We had a fabulous week here which surpassed expectation. The One and Only deserves the title 'luxury' because it is: calm, pristinely maintained, welcoming and on the most fantastic stretch of beach front. The staff were without exception outstanding and the whole experience a real pleasure. Will..."
A Traveller, Jun 2016, GB
297 people looked at this hotel in the last hour
Most recent review
"We had a fabulous honeymoon at the Al Qasr, Jumeirah. The staff were exceptionally friendly and helpful and the range of restaurants was amazing. The half board package allowed us to choose from a huge number of restaurants, some with a small additional charge, but this was clearly highlighted so..."
A Traveller, Jun 2016, GB
277 people looked at this hotel in the last hour
Most recent review
"Yes I could come up with some tiny niggles, but this hotel break was as close to perfection as I've ever experienced. The staff were unfailingly polite, friendly and helpful, you couldn't be closer to a beautiful beach where you are shown to your lounger with towels provided, water on ice, chill..."
A Traveller, Jun 2016, GB
224 people looked at this hotel in the last hour
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"Enjoyed every moment definitely will b going back "
A Traveller, Jun 2016, GB
178 people looked at this hotel in the last hour
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"the best hotel I have ever stayed in . it's a taxi ride away from the main areas. I recommend the four seasons to anyone that just wants to relax and get away from it all"
A Traveller, Jun 2016, GB
172 people looked at this hotel in the last hour
Most recent review
"New hotel with excellent design and colors, nice location near to souq waqif, just need some management follow up on guest comfort. we face a problem with hot water and path shower.entrance a little small. "
A Traveller, May 2016, US
113 people looked at this hotel in the last hour
Most recent review
"Great beach holiday. Good butler service. Some restaurants are really good and some are poor on the quality of food and service. You have to pick the right restaurant. One would expect that all the restuarants within the Jumeirah will be great but unfortunately not. "
A, Jun 2016, GB
Map of hotels in Jumeirah Beach
- Burj Khalifa
- Dubai Mall
- Jumeira Beach and Park
- Mall of the Emirates
- Deira City Centre
- Gold Souk
- Wafi City Mall
- Dubai International Convention and Exhibition Centre
- Dubai Creek
- Naif Souq
- Dubai International Financial Centre
- Wild Wadi Water Park
- The Dubai Fountain
- Jumeirah Lake Towers
- BurJuman Mall
- Dubai Marina Mall
- Dubai Sports City
- Dubai (XNB-Dubai Bus Station)
- Souk Madinat Jumeirah
- Dubai Festival City Mall
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text:
Interleukin-21 differentially affects human natural killer cell subsets
Version of Record online: 16 JUL 2007
DOI: 10.1111/j.1365-2567.2007.02675.x
Volume 122, Issue 4, pages 486–495, December 2007
Additional Information
How to Cite
Wendt, K., Wilk, E., Buyny, S., Schmidt, R. E. and Jacobs, R. (2007), Interleukin-21 differentially affects human natural killer cell subsets. Immunology, 122: 486–495. doi: 10.1111/j.1365-2567.2007.02675.x
Publication History
- Issue online: 19 OCT 2007
- Version of Record online: 16 JUL 2007
- Received 25 January 2007; revised 5 April 2007; accepted 7 June 2007.
- Abstract
- Article
- References
- Cited By
- cell activation;
- human;
- interleukin-2;
- interleukin-21;
- natural killer cells
Interleukin-21 (IL-21) is a cytokine with pleiotropic effects on various cell types including dendritic cells, B cells, T cells and natural killer (NK) cells. To evaluate if IL-21 affects human NK cell subpopulations in a similar fashion, functional studies were performed on CD56dim and CD56bright NK cells, both bearing IL-21 receptors at identical densities. Stimulation with IL-21 strongly induced proliferation of CD56bright NK cells and cytotoxicity against K562 target cells was preferentially augmented in CD56dim NK cells. In contrast, stimulation with IL-2 and IL-21 alone or in combination failed to induce interferon-γ and tumour necrosis factor-α production in the two NK cell subsets. Intracellular analysis of signal transducer and activator of transcription (STAT) proteins revealed that IL-21 by itself induces phosphorylation of STAT1 and STAT3 in CD56dim NK cells, and to an even higher degree in CD56bright NK cells. In this CD56bright NK cell population alone, IL-2 weakly phosphorylated STAT1 and STAT3, which was further increased when cells were treated with the combination of both cytokines. In contrast, STAT5 was strongly phosphorylated only in CD56bright NK cells by low-dose IL-2, while IL-21 did not affect STAT5 at all. In summary, we present data indicating that the NK-cell-directed cytokines IL-2 and IL-21 not only affect functions in NK cell subpopulations differently but can also act additively.


text:
Genpak Square and Rectangular Deli Containers
Square Deli Containers Are Convenient, Stackable, and Durable Enough for Any Foods
Square deli containers are necessary in any take-out restaurant, deli, or supermarket. Use them to package a variety of food items ranging from trail mix, bulk nuts, and dry ingredients to pasta salad, condiments, and fruit. You can even fill these rectangular deli containers with candy, scones, cookies, and treats to sell in your cafe or at your market stand. Whether you're looking for the containers, lids, or kits that include both, we have you covered.Also make sure to check out other great items from Genpak.


text:
3rd suspect in killing of grandmother due in courtApril 10,2014The Associated Press
ST. JOHNSBURY -- The third suspect charged in the kidnapping and killing of a Sheffield grandmother is due in a Vermont courtroom.
Michael Norrie, 23, was returned to Vermont on Wednesday from a federal prison in Pennsylvania. He's due to appear in Superior Court in St. Johnsbury Thursday.
Norrie is facing charges of first-degree murder and other offenses stemming from the September 2010 abduction and killing of 78-year-old Pat O'Hagan.
Last month, two of Norrie's cousins, 33-year-old Keith Baird and 27-year-old Richard Fletcher, pleaded not guilty to charges from the same case.
Police affidavits say O'Hagan was shot in the back of the head with a stolen pistol.
Before being charged in the O'Hagan case, all three suspects were in state or federal prison on other charges.MORE IN This Just InNORTH BENNINGTON Two public meetings, in North Bennington and Shaftsbury, have been set for... Full StoryThe Board of Aldermen has endorsed a major jump in city pension funding. Full StoryHUBBARDTON The annual celebration of Hubbardton has been moved to Sunday due to the weather... Full Story
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1985 chevy caprice classic 5.0L
whats the problem and how can I fix it?
when/if the engine rotate it rotates slow and make a loud scratching noise and dont turn over.
i have to pull on the belt to get it to turn over and this sometime work
Wednesday, November 24th, 2010 AT 9:59 PM


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The website is focused on six themes, drawn from the concerns and aspirations of Queens residents, that explain the vision for the QueensWay and the QueensWay Plan Map.
The Map highlights a concept design for the landscape and amenities that responds to the community needs and goals. Details can be found by clicking on the six geographic zones or zooming in.
The QueensWay is a connector. At its heart is Forest Park. To its south lies Gateway National Park and the Jamaica Bay Gateway Greenway, and to its north is Flushing Meadows-Corona Park.
The QueensWay will be a new park for all ages and for all seasons for neighborhoods that don't have easy access to open space.
Restored native plantings, improved wildlife habitat and rain gardens for managing stormwater will establish the QueensWay as an environmental showcase that creates educational opportunities for students, local residents, and visitors.
The QueensWay can be a greenway unlike any other in the world by tapping into the borough's rich traditions and cultures.
The use of lighting, patrols and technology will support a secure park environment, and careful design will ensure ease of use for visitors while creating buffers between the QueensWay and nearby homes.
The QueensWay can be a City-owned and managed park with a new QueensWay Conservancy to manage programming and outreach for park events and philanthropic fundraising.
Sunday, Jul 10, 2016
9:00 am – 2:45 pm
We are regulars at the GrowNYC Forest Hills Greenmarket and we always look forward to going back to set up our table information sessions! Read More
Elected Officials, Friends of the QueensWay and The Trust for Public Land announce Launch of Design Process for Phase 1 of the QueensWay and call on city to fund this historic, family-friendly park for Queens By The Trust for Public Land and Friends of the QueensWay… Read More
Saturday, Jun 18, 2016
11:00 am – 3:00 pm
In our 3rd year of hosting a QueensWay Bike Tour, we are co-leading again with our friends at Five Borough Bicycle Club (5BBC) and TA Queens Committee. Join us in a ride from Rego Park to… Read More
Saturday, May 7, 2016
1:00 pm – 3:30 pm
The 2.5-hour foraging tour begins at 1 PM, Saturday, May 7, at the NE corner of Woodhaven Blvd. and Forest Park Drive, outside Victory Field, in Woodhaven, Queens. The suggested donation is $20/adult, $10/child under 12. At… Read More
Saturday, May 7, 2016
11:00 am – 1:00 pm
Join guides from The Trust for Public Land and the Friends of the QueensWay, for a 2 mile walk alongside the northern section of the proposed QueensWay – that will transform a long abandoned rail line running… Read More
Sunday, May 15, 2016
9:00 am – 3:00 pm
The best part about having our info booth at the GrowNYC Forest Hills Greenmarket next to seeing familiar faces and meeting new ones, is that we get to also meet great local farmers and vendors with… Read More
Saturday, Apr 16, 2016
8:00 am – 2:30 pm
To kick off our Spring season, we are having our first table in the foyer of the Michael's Arts and Crafts thanks to the great folks at Trader Joe's in Rego Park, Queens. We look forward to engaging… Read More
Tuesday, Jun 23, 2015
2:00 pm – 6:00 pm
We are proud to be a participant of the Daffodil Project 2015 coordinated by New Yorkers for Parks. The Daffodil Project originally began as a living memorial to September 11th and the tradition continues. We will plant daffodil bulbs… Read More
3 Things I Learned About Queens On The QueensWay Bike Tour By Tarley Jordan, Forest Hills Resident I've lived in Forest Hills in Queens for just over three years, and I first heard about this idea… Read More
Saturday, Jun 20, 2015
11:00 am – 1:30 pm
Join Friends of The QueensWay, 5BBC (5 Borough Bicycle Club), and TA (Transportation Alternatives) Queens Committee members in a ride from Rego Park to Ozone Park to explore the future route of the QueensWay. We will… Read More


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July 2016
Well structured and well done tour of beautiful Moscow metro. Recommended for first timers in the city.
Delwyn N Australia
July 2016
This is a must do tour as it's very hard to navigate the subway but also the history info behind each subway station help make it even more amazingly. Informative guide with a great sense of humour.
Well worth doing...stunning artwork, statues and mosaic stain glass.
July 2016
Our guide was very knowledgeable and gave us a very good overview of the Metro.
June 2016
This tour is a MUST DO! The Metro in Moscow is absolutely amazing! I loved learning the history of the stations, and the beauty of the stations is unbelievable!
June 2016
The tour was very interesting. Friendly and informative guide who not only showed us the highlights of the metro, she also informed us of how to use the metro which gave us the confidence to travel to different destinations all over the city on our own. Not being a Russian speaker its challenging.
June 2016
Our tour guide Elena is great. Her English was just awesome and she explained very good, the organisation was perfect. She showed pictures, she is funny, made cute comments and so on. Fully recommended.
June 2016
5 star since the guide was so knowledgeable. great way to learn about commie influence and how much of this actually is propaganda for the people. Now Moscow is left with the most beautiful metros in the world.
April 2016
Excellent tour guide Marina!
January 2016
Thanks to Irina - the tour was really great.
Very interesting.
November 2015
Irina was very informative and slick, covering 11 stations in 90 minutes. Beautiful stations, each with its own historical background and significance for the Russian people.
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Today, I was at my boyfriend's grandmother's house meeting her for the first time. I excused myself to the restroom and as I walked out of the room I heard her say, "You could do a lot better. She's fat." Then I heard my boyfriend reply, "I know." FML
by Anonymous / 02/18/2013 at 2:09am / United States (Kentucky) / Love
Today, I got my results on a recent, important midterm. During the exam, I'd noticed my instructor had accidentally left an answers page in the test packet, so being honest, I didn't look at them. It turns out she did it on purpose to help us pass. I failed. FML
by its ok to cheat!? / 02/20/2013 at 4:52pm / United States (California) / Miscellaneous
Today, I went to the doctor to get a blood test and I started crying when I saw the needle. I planned on becoming a doctor. FML
by Caroline / 02/24/2013 at 4:34am / Denmark (Hovedstaden) / Health
Today, I was hanging out with the guy I really like. I lifted my arms to put my hair in a ponytail when he noticed a hole that had apparently tore in the armpit of my shirt, so he put his finger through it. I haven't shaved in weeks. FML
by Anonymous / 02/19/2013 at 1:19am / United States (Pennsylvania) / Love
Today, my boss told me to go outside and take part in the company's stupid Harlem Shake video. When I declined, he threatened to fire me if I didn't take part. I ended up being the guy who had to furiously pelvic thrust before the music dropped. FML
by mypelvishurts / 02/23/2013 at 2:32am / United States (California) / Work
Today, my husband and I were fooling around in the shower. For some reason, I thought it'd be a good idea to grab his man meat and show him how to wash someone at a nursing home. He said he'd never be turned on by a nurse again. I'm a nurse. FML
by tomedicalforlove / 02/21/2013 at 12:51am / Love
Today, a guy I went on one date with asked me out again via text. Being honest, I texted back, politely saying that he was a good guy but I wasn't really interested. He came over to my house, screaming about how awful I was for "text message breaking up with him" and then cracked my windshield. FML
by fuckedover / 02/26/2013 at 11:43am / United States / Love
Today, I was trying to be sexy and change in front of my boyfriend. As I was changing, he started to talk to me about how we should both try and lose weight. FML
by pooh anne / 02/26/2013 at 3:26pm / United States (Arkansas) / Love
Today, my fiancé is returning home, so I decided to wax myself, thinking things would get intimate. I warmed the wax strips and set them on the counter. Our cat jumped onto the counter and managed to roll onto one of the strips. Suffice to say, the wrong pussy got a painful waxing. FML
by Anonymous / 02/25/2013 at 12:57pm / Canada (British Columbia) / Intimacy
Today, l took my new boyfriend to the place where my ex and I used to hook up, only to find out that my ex and his new girl had the same idea. FML
by wrongplacewrongtime / 02/22/2013 at 1:12am / United States (Texas) / Intimacy
Today, my girlfriend broke up with me because she could not stand the thought of being in a relationship with a man who wears orange. This is the first time I've worn an orange shirt in at least 6 months. FML
by vat / 02/25/2013 at 3:33am / Hong Kong / Love
Today, I found an old toy that I gave to my daughter several years ago. It was still unopened, and long forgotten, so I decided to re-gift it to one of my friend's children. My daughter immediately remembered her "favorite" toy and started crying inconsolably. FML
by Great. / 02/22/2013 at 5:32pm / Brazil (Minas Gerais) / Kids
Today, my boyfriend of three years told me he was thinking about us taking a break. After an hour of crying and him saying it would be okay, I accepted it. When I asked when the break would start, he replied, "What are you talking about? I only said I'd thought about it" and then laughed. FML
by Gullible / 02/25/2013 at 1:10am / United States (Ohio) / Love


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Lovely, fine-art images of beautiful horses decorate these premium-quality dishes that are perfect for desserts, snacks, and more. Microwave and dishwasher safe.
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Overview (2)
|Date of Birth
|1925, Exeter, England, UK
|Date of Death
|17 November 2003, Sydenham, London, England, UK (natural causes)
Mini Bio (1)
Peter Clapham was born in 1925 in Exeter, England. He was an actor, known for The Phantom of the Opera (1989), The Sailor Who Fell from Grace with the Sea (1976) and Thirteen at Dinner (1985). He died on November 17, 2003 in Sydenham, London, England.


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I'm trying to deal with timezone information in Django. I tried doing something like:
results = Competitor.objects.raw("SELECT official_start AT TIME ZONE 'UTC', official_finish AT TIME ZONE 'UTC' FROM competitor WHERE race_id=1")
Thinking that this way I would know that the timezone was UTC but say I store a time in the database that is '2010-07-30 15:11:23' in UTC, in Django it will show up as '2010-07-30 10:11:23'. Any idea what is going on?


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Press Releases & Essays
ANA-NY Appoints Keuka College Alumnae Dr. Jeanine Santelli as Executive Director
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Dr. Santelli helped found the organization to give nurses a voice at the national level.
Hiking for Inclusion at Cumming Nature Center
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Students in Keuka College's D.R.I.V.E. program will lead a hike July 23.
Mike Healy to Receive 2016 Stork Award
Read More
Penn Yan resident will be honored for community service Aug. 16.


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