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Tag Archives: Berkeley Post Office
Green Party's Jill Stein joins Berkeley Post Office rally
US Presidential Green Party candidate Jill Stein took part in a rally at the downtown Berkeley Post Office Friday whose broad stated aim was to "let voters and the Department of Justice know how to keep the public sector viable."
The US Post Office wants to sell the Allston Way post office, but has met resistance from the city and some Berkeley residents. In the latest salvo — in a battle that dates back four years to 2012 when the intended sale was announced — the DoJ warned the city of Berkeley that a lawsuit could be coming over the city's "interference" with USPS plans to sell the building.
Read more about the fight surrounding the downtown Berkeley post office.
Friday's rally, which was organized by the Green Party and the Berkeley Post Office Defenders group and attended by around 50 people, aimed to raise awareness of "public resources facing privatization by high-profit corporations;" to defend union jobs; to encourage the "wise use of common space; to allow access to the so-called Berkeley Post Office Community Garden established by protesters who camped outside the building for months before they were evicted; to promote postal banking; and to take action faced with "corporate control of government and media." … Continue reading »
Tagged Berkeley Post Office
DOJ threatens lawsuit over Berkeley post office
In a strongly worded letter, the U.S. Department of Justice has warned the city of Berkeley that a lawsuit could be coming over the city's "interference" with USPS plans to sell its downtown post office on Allston Way.
The DOJ's Civil Division sent the letter — stamped April 28 — to Mayor Tom Bates, and asked for a response by May 20 if the city hopes to resolve the issue without litigation.
Read more about the fight surrounding the downtown Berkeley post office.
According to the letter, from Director Joseph Hunt of the Federal Programs Branch of the Civil Division, the city's downtown historic overlay is the issue. The overlay restricts a nine-parcel section of the downtown to civic, non-profit uses. The main Berkeley post office, at 2000 Allston Way, falls within those boundaries.
"In purporting to restrict the Berkeley Post Office parcel… to such civic or nonprofit uses, the Ordinance prohibits any commercially viable uses for the Property," Hunt writes. … Continue reading »
Berkeley post office protesters cleared out in early morning raid
Just before 5 a.m. Tuesday, U.S. Post Office inspectors cleared the protester encampment on the steps and on the side of the downtown Berkeley Post Office. Protesters from First They Came for the Homeless and the Berkeley Post Office Defenders had occupied part of the post office property for over 17 months.
"Since November 2014 we've been giving out information, providing materials saying you can't stay," said Jeff Fitch, a spokesman for the U.S. Postal Inspection Service. "We've been encouraging people to not camp there. The decision was made to come in this week and conduct the operation."
Read more about the Berkeley Post Office.
Fitch said eight people were removed from the site and four federal misdemeanor citations were issued, for obstructing access and for not following instructions from authorized postal security officers. No arrests were made.
According to Mike Wilson, an organizer of the Post Office Defenders, protesters had been assured that they would not be removed for trespassing. He said there were five protesters at the post office overnight and a number of homeless people not associated with the protest in the garden on Milvia Street. … Continue reading »
Judge dismisses Berkeley's bid to stop sale of post office
A U.S. Federal Court judge on April 14 dismissed the city of Berkeley's lawsuit to stop the sale and relocation of the city's main post office on Allston Way. However, from the city's perspective the news is not all bad.
In deciding that the city's case was moot, Judge William Alsup ruled that the United States Postal Service "had to formally rescind its decision to relocate the post office from 2000 Allston Way," according to a summary prepared by Berkeley city attorneys.
That means, for now, the Main Post Office is not officially for sale. … Continue reading »
Tagged Berkeley Post Office, Downtown Berkeley, USPS
Legal battles over Berkeley's main Post Office continue
The city of Berkeley is pushing forward with a lawsuit to stop the sale of the downtown Berkeley Post Office, despite the U.S. Postal Service's claim that it is unnecessary as there is no imminent plan to sell the building, an attorney working for Berkeley told a crowd at a community meeting Thursday.
After a deal between the USPS and local developer Hudson McDonald fell through in early December, and the building at 2000 Allston Way was taken off the market, the postal service filed a motion Jan. 22 to dismiss the lawsuits against it, saying they are moot without a prospective buyer interested in the building. Whether the Berkeley Post Office is placed back on the market is under consideration, according to USPS spokesperson Augustine Ruiz.
Read more about the Berkeley Post Office.
The city and the privately funded nonprofit National Trust for Historical Preservation, which filed separate lawsuits in November, argue that their original complaints remain unaddressed by the USPS, and the case needs to move forward to prevent repeated violations in the future. … Continue reading »
Deal to buy Post Office fizzles; police clear encampment
The proposal by Berkeley developers Hudson MacDonald to buy the downtown Berkeley Post Office has fallen through after they were unable to reach agreement with the Post Office on a deal.
Meanwhile, police from the U.S. Postal Inspection Service prompted an orderly clearance of parts of the makeshift encampment at Berkeley's main Post Office Thursday morning. Protesters, who call themselves Berkeley Post Office Defenders, and a homeless advocacy group, First They Came for the Homeless, have been camped around the building for four weeks.
According to a spokesperson for the U.S. Postal Inspection Service, officers provided protesters with a list of federal regulations and criminal statutes that prohibit the encampment. No arrests were made. … Continue reading »
Berkeley temporarily blocks sale of main Post Office
The city of Berkeley has gotten a temporary restraining order blocking the sale of the city's main post office on Allston Way.
U.S. District Court Judge William Alsup ruled Nov. 5 that the U.S. Postal Service cannot sell the building before he conducts a full hearing in San Francisco on Dec. 10. USPS has committed to not closing a sale on the property before Dec. 17.
The city of Berkeley, along with its outside counsel Antonio Rossmann, filed for the TRO after learning online that the USPS was in contract to sell the building. Despite repeated requests and a Freedom of Information Act request, the USPS has refused to disclose the identity of the buyer.
On Nov. 5, Berkeleyside revealed that local developer Hudson McDonald was in negotiations to purchase the historic property. The firm would like the post office to remain in the front part of the building, according to Chris Hudson, a principal. The firm plans to put retail in the back portion of the property, which is currently sitting empty. … Continue reading »
Exclusive: Local developer Hudson McDonald in contract to buy downtown Berkeley Post Office
After weeks of silence, Berkeley developer Hudson McDonald has acknowledged that it is the company that is negotiating with the USPS to buy the main Berkeley Post Office at 2000 Allston Way.
If successful, Hudson McDonald, which is best known for the construction of the Trader Joe's building on University and MKL Jr. Way, said it plans to restore the 1914 building and develop the back for retail operations while offering the Post Office the opportunity of continuing to use the front lobby for postal services.
"There is a lot to be determined," Chris Hudson, co-principal with Evan McDonald of the developer, said Tuesday. "But we want to preserve and restore the building, including retrofitting it, and we are having a conversation with the post office about them being tenant in the front part." Currently about 80% of the building is empty.
Hudson said the Post Office had received several offers for the building but that Hudson McDonald was the only bidder in negotiation with USPS. … Continue reading »
Ralph Nader speaks at rally to save Berkeley post office
Longtime political activist Ralph Nader spoke Tuesday afternoon at a demonstration at the downtown Berkeley post office on Allston Way in support of the on-going fight to stop the U.S. Postal Service from selling the 1914 building.
"This is not just a matter of stamps or delivery on Saturdays, important as that is," Nader said to the crowd. "This is a fundamental institution that binds the country together." … Continue reading »
Satellite post office at Berkeley Staples draws protests
For the last 19 nights, Mike Zint, 47, has been sleeping sitting up in a chair in front of the Staples store at 2352 Shattuck Ave. He has set up vigil in downtown Berkeley to protest the "privatization" of the U.S. Postal Service, as well as chronic homelessness in the United States.
Zint is part of a small group of homeless activists that has established a camp of sorts on the sidewalk. During the day, they pass out leaflets protesting the seven-month-old deal allowing Staples to run satellite postal operations in 82 stores across the country, including the one in Berkeley. They have a table piled with leaflets talking about the deal, as well as information about the U.S. Post Office's plan to sell the Main Post office on Allston Way. … Continue reading »


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Boxing: Manny Pacquiao 'to retire' after Timothy Bradley fight
Pacquiao lost by unanimous decision to his brash arch-rival Mayweather, whom he fought with a torn rotator cuff that later required surgery.
Timothy Geithner grilled in court over AIG bailout
On Tuesday, Geithner affirmed his belief that the bailout was needed to avert disaster for the financial system. Geithner was president of the New York Federal Reserve at the time of the rescue and la...
Timothy Geithner grilled in court over AIG bailout
Geithner is due back in court Wednesday in a trial of a lawsuit filed by the insurance gia...
Timothy Geithner affirms in court need for AIG bailout
A lawyer on Tuesday grilled Geithner during the trial of a lawsuit brought by former AIG Chairman and CEO Maurice Greenberg.
Historic President Barack Obama visit to give fillip to ties: Timothy Roemer, Former US Ambassador to India
Terrorists are also threatening our two great democracies. Two countries that share common values have to defeat terrorism for pluralism to succeed.
Timothy Geithner to Join Buyout Firm Warburg Pincus
Timothy Geithner is joining private equity firm Warburg Pincus after a quarter-century career in public service.
US considered nationalising banks: Former treasury secretary Timothy Geithner
In "Stress Test: Reflections on Financial Crises", the former treasury secretary details behind-the-scenes anecdotes and says he tried to resign multiple times.
UN could be helpful participant to resolve India-Pakistan border crisis : Timothy Kaine
Yesterday, UN Secretary-General Ban Ki Moon has asked India and Pakistan to resolve their issues diplomatically and through dialogue.
Looking for 17% earnings growth next year: Timothy Moe, Goldman Sachs
We are looking at about 12% earnings growth this year and about 17% next year as an economic recovery begins to gather pace.
Quality of companies this time around is far superior than dot com companies: Timothy Mahapatra, head, global financial advisory, Deloitte
Global survey shows that for the first time after five years, major companies are now prepared to deploy capital into M&A and capital expenditure.
Pullback in equities is a good opportunity to buy: Timothy Riddell, ANZ
"I do not see a lot of strength in the rupee coming through the next year."
Fair amount of money waiting on sidelines, looking for opportunity in markets: Timothy Moe, Goldman Sachs
"If the market was to pull back a little bit from here, there is a fair amount of money waiting on the sidelines, looking for an opportunity to re-engage."
Stress Test, Timothy Geithner's book, reveals consensus not vision during crisis
The former Treasury secretary's new book, "Stress Test," has stirred up the old debates and anger: How the bailout was overly generous to the banks and bankers.
Prospects of Indian equity markets look subdued: Timothy Moe, Goldman Sachs
"The recent move by PBOC in terms of reducing some limits on the floor of lending rates is an incremental step towards deregulating overall interest rates."
'Won't lose sleep over Jet-Etihad ': Timothy C Clark
Emirates president Timothy C Clark had "politely declined" an offer from Jet Airways management to pick up stake in the airline.
Politics playing vital role in market price formation: Timothy Moe, Goldman Sachs
'We are not taking a view on parties nor on the outcome of the election. All we are doing is observing investors — both offshore as well as onshore.'
Timothy Geithner, Ben Bernanke discuss global economy with RBI, India Inc
US Treasury Secretary Timothy Geithner and Fed Reserve Chairman Ben S Bernanke today discussed global economic situation and monetary policies with the RBI Governor.
Indian business heads meet Timothy Geithner, Ben Bernanke
Among those present were ICICI Bank's Chanda Kochhar, Hari Bhartia from Jubilant Bhartia Group, and Rajiv Lall from IDFC.
Reforms will restore investor confidence in Indian economy: Timothy Geithner
Encouraged by India's recent reforms initiatives, US Treasury Secretary Timothy Geithner today said these will restore confidence of global investors in the country's economy.
US Treasury Secretary Timothy Geithner postpones India visit
"Mukherjee has been an effective ally in the G-20 and a strong partner in deepening the economic relationship between the United States and India," the Department of Treasury said in a statement.
Timothy Geithner to visit India later this month for economic talks
US Treasury Secretary Timothy Geithner will meet India's finance minister in Delhi in June to strengthen economic and financial ties.
India, Pakistan making remarkable progress in improving ties: Timothy Roemer
The former US ambassador said that it all started with talks on terrorism issues then there was some confidence building measures.
US economy getting stronger; world situation uncertain: Timothy Geithner
The US economy is gradually getting stronger and it can be seen across the country, US Treasury Secretary Timothy Geithner has said.
Europe must be creative, aggressive in crisis, says Timothy Geithner
Geithner said Europe's effort to prevent the spread of its debt crisis depends on the willingness and ability of the region's leaders to act aggressively and creatively.
I don't see China becoming a superpower in this century: Timothy Beardson
The most significant is the demographic challenge and it has four facets: higher wages, ageing, a declining population and gender imbalance.
Timothy Geither urges Congress to support IMF, World Bank
Asserting that aide by multilateral financial institutions had a crucial role in the growth of countries like India.
India has been very supportive on sanctions against Iran: Timothy Geithner
Timothy Geithner has lauded India for being "very supportive" in many respects on the issue of sanctions against Iran.
Asian economies need to stimulate demand at home: Timothy Geithner
Economies on the Pacific rim will need to do more to stimulate demand at home, US Treasury Secretary Timothy Geithner said.
India has the potential to grow 8-9%: Timothy Moe, Goldman Sachs
"The current range of growth rate now is 5% to 6%, which is very much at the low end of the last decade's achieved levels. "
Earnings slope, valuation expansion can take Nifty to 7,000: Timothy Moe, Goldman Sachs
"To get to 7k Nifty target would basically entail riding the underlying earnings slope and maybe having a tad valuation expansion," says Timothy Moe.
India is a good rebalancing story: Timothy Geithner
Timothy Geithner discussed the contours of economic recovery, India's tackling of the crisis, and much more with ET.
Rapid Indian economic growth poses no threat to US: Timothy Geithner
Treasury secretary Timothy Geithner said India's economic expansion does not threaten the US and is helping the American economy's recovery.
Reforms to boost economy, recent steps have restored faith in India: Timothy Geithner
"The recent reforms advanced by PM and FM will help provide a foundation for stronger economic growth" Timothy Geithner said on Tuesday.
India's reform measures very significant, will fuel private investment: US Treasury Secretary Timothy Geithner
He added that the reforms outlined by India offer a very promising path to improving growth outcomes for the country.
Globalisation, connectivity will overtake protectionism in the West: Timothy Flynn, KPMG International
Timothy Flynn, Chairman, KPMG Int'l, says we need to have open markets both for talent and goods and services to move as an inter-connected world.
Timothy Geithner, German Finance Minister Wolfgang Schaeuble emphasise need for cooperation for growth
US and Germany will continue to work together closely with their partners to stabilise the economies in Europe and around the world.
Obama names Timothy Roemer as US ambassador to India
Roemer was a former September 11 commissioner endorsed Obama during his primary campaign and was a strong advocate of Obama's foreign policy approach.
Treasury Secretary Timothy Geithner sees threat to US economy from Europe crisis, Iran
Treasury Secretary Timothy F Geithner said the US faces risks from the crisis in Europe while the confrontation with Iran has helped drive up oil prices.
Timothy Geithner to raise US business concerns over tax law changes in India
A dozen US business groups have asked US Treasury Secretary Timothy Geithner to raise their concerns with New Delhi on some proposed changes in Indian tax laws.
Wine investing: When bankers like Brian Mota and Timothy Clew quit Wall Street to find $50 million for wine
Their firm TWT Investment Partners is in the process of raising as much as $50 million for the trust, the only private-equity-structured wine-investment fund in the US.
Ford India appoints Timothy Tucker as VP sales
Automaker Ford India today announced the appointment of Timothy Tucker as its Vice- President of sales. He will be based here.

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Herb Depke
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My genealogy file is found at RootsWeb:
where I am "Living Depke." Find me by my father, Herbert Frederick Depke, born 1907. This file is also on Ancestry.com. Born in Danville, Vermilion County, Illinois, I now live in Cary NC 27511. My file is also on Ancestry.com
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Hello Herb,
I am sorry but I just got your message that there was a transcription error for F. Heinrich Depke. It was down in the "flower/note" section which Find A Grave doesn't notify people of. If you find another error, please use the "edit" button. Find A Grave still doesn't send me an email that there is an edit awaiting review but it does put a notice on my page. I check fairly often for those. Even if I were to miss one, Find A Grave automatically accepts a change if I don't respond.
Secondly, I am not related in anyway. I will gladly transfer the care of the Depke memorials over to you. You just need to let me know that is ok to do. This will give you the ability to manipulate the memorial post to help other genealogist better.
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Delois Sally Foster Lynch
Hi Herb
My mother passed away last 4th July. I posted her memorial on Find A Grave. # 55183360. I thought you would like to add her to your Foster information.
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Thank you so much for posting the photos of Mildred. Her mother, Ida Bell Foster, is related to my mother. Who is also a Foster from Arkansas.
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If you head to see 'In the Land of Blood and Honey' this December, bring your reading glasses. According to Deadline, Angelina Jolie's directorial debut about the Bosnian War in the mid-'90s will hit theaters in the country's native language. Known as Serbian-Croatian during the war, the language is now called Bosnian/Croatian/Serbian; Jolie shot the 'In the Land of Blood and Honey' in both BCS and English in… Continue reading 'In the Land of Blood and Honey': Angelina Jolie's Directorial Debut Will Hit US Theaters With Subtitles
Tag Archive: land
'In the Land of Blood and Honey': Angelina Jolie's Directorial Debut Will Hit US Theaters With Subtitles
We don't often post development deal stories, but having broken the sad new that MTV's The Buried Life was getting the ax this week, we wanted to add this feel-good update: Duncan Penn, Jonnie Penn, Ben Nemtin, Dave Lingwood have signed a deal with MTV's cross-platform media group MTVX to work on new shows and online projects.
"We were proud of the show we had made, but it wasn't… Continue reading 'Buried Life' guys land MTV development deal — EXCLUSIVE
Review in a Hurry: With its mixture of alpha-male honor and father-son estrangement issues, Warrior feels like a movie strongly calculated to make grown men cry. Yet despite strong work by Tom Hardy and Nick Nolte, the only thing here worth shedding tears over is the brutally inadequate… Continue reading Movie Review: Warrior Throws a Lot of Punches, but Doesn't Land Many
by radio detection and ranging Staff
The Royals have arrived!
The Duke and Duchess of Cambridge landed Friday afternoon at the Los Angeles International Airport, after wrapping up their nine-day whirlwind tour of Canada.
California Gov. Jerry Brown, Mayor Antonio Mayor Antonio Villaraigosa, and British Consul-General Dame Barbara Hay greeted the royal couple upon their 3:55 pm arrival at LAX Airport.
PHOTOS: William & Kate Land In Los Angeles
Catherine, who looked beautiful… Continue reading Prince William & Kate Land In Los Angeles!
ComingSoon.net's horror site ShockTillYouDrop.com has interviews for IFC Midnight's new release Stake Land , directed by Jim Mickle ( Mulberry Street ), and starring co-writer Nick Damici, Connor Paulo ( Gossip Girl ), Kelly McGillis ( Top Gun ), Danielle Harris ( Halloween ) and Sean Nelson. You can read the interviews for the movie by clicking on the appropriate link below.
Director Jim Mickle
Nick Damici and Connor… Continue reading ShockTillYouDrop's Exclusive Stake Land Interviews


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On a fresh install of Windows Server 2012 R2 in a Hyper-V host role, with four VMs running but idle and nothing going on in any of the VMs or on the host, I get a periodic CPU spike on a regular periodic basis (about every 12 seconds). The process that's generating the spike, per Task Manager on the host machine, is vmms.exe. The spike are pretty severe, lasting a few seconds and using close 80-100% of one core. What would be causing this? How can I diagnose it (i.e. other than knowing that it's vmms.exe)?
Periodic CPU spikes from VMMS indicate that you're running some monitoring tool that is polling information about the VMs. This could be the Hyper-V manager, System Center Virtual Machine Manager, etc.


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Golfing World: Top 10 shots in Open history
Golfing World counts down 10 of the greatest shots ever seen at The Open.
Top moments in The Open: Arnie, Seve, Tiger, Jack
Gary Williams, Charlie Rymer and John Cook review the top moments of The Open.
Golfing World: Open de France 100th celebration
To celebrate the 100th edition of the Open de France, This Week in Golf looks back at the event's long and illustrious history.
Kendall: Four keys for higher, softer wedge shots
Golf Channel Academy Lead Coach Dave Kendall shares four keys to hit higher and softer wedge shots.
Rahm honors Seve, makes U.S. Open cut
Jon Rahm wore blue pants and a white shirt Saturday at the U.S. Open. It was a tribute to his hero, Seve Ballesteros.
Lerner: Seve's heart forever beats on European Tour
Rich Lerner shares why the spirit of Seve Ballesteros will forever live on the European Tour.won this championship. He was, and still is to this day, the European tour's most important and beloved figure. A mercurial blend of Houdini and Hogan, he returned from his time in America with a chip on his shoulder. turbo charged what had been a Ryder cup . His passion, more than anyones, turning it into the roaring special it is today. His spirit lives, setting forever the beating heart of a crowd tour, a european tour .
Seve to Finchem: 'Need bailout' on TPC Sawgrass No. 17
PGA Tour commissioner Tim Finchem shares a funny story about Seve Ballesteros wanting a bailout option on the par-three 17th island green at TPC Sawgrass.
Golfing World: Caddie recalls Seve's best shot
Billy Foster, who used to caddie for legend of the game Seve Ballesteros, looks back on the greatest shot he has ever seen which was produced by Seve while Billy was on his bag at the 1993 European Masters.as ever. Over three decades the Spaniard won 91 titles, including five Major championships . He's perhaps best known for his unique shot-making ability which endeared him to a generation of fans including many top players on
Fairways of Life: Sutton's best Seve story
Hal Sutton shares his best Seve Ballesteros story on Fairways of Life with Matt Adams at the 2016 PGA Merchandise Show.ever saw anybody with and the truth is he was in his subconscious mind all the time. He had the most vivid imagination. He would see two and three shots that were. One other person would always say one shot, he could do it three or four different ways. Most people can't do it three or four different ways, but he did it all with his subconscious mind and his feel, if you were to ask Seve how Used to ask him all the time. Say he would tell me all the time. If you could hit it for me and I could take care of the short game. We win every week And that would have probably been a case but I didn't have a short game- That's the first time we ever done a savvy act set off. But anyway You know? Was unbelievable. We play in, Larry and he, played him in the 87 Ryder Cup . He and Olazabel. And, we were one up going in to 16. Yeah. And Olazabel missed it right. And missed it left.
Golfing World: Olazabal gets emotional
Ahead of his 50th birthday, Golfing World sat down for an emotional catch up with two-time Masters champion Jose Maria Olazabal at the Invitational event he hosted alongside tennis superstar Rafael Nadal towards the end of 2015a lot. A lot. I have to say that I follow A European Tour , the PGA in America, the LPGA. And at moments it's been really difficult and hard. But there is not much more that
Nelson on battling Ballesteros in '79 Ryder Cup
Larry Nelson reflects on battling Seve Ballesteros at the 1979 Ryder Cup.to ask you a couple questions. First of all, at the 1979 Ryder Cup , here are your first two Ryder Cups, '79 and '81. You're 9-0 in what is normally a crucible of pressure for anybody.So he was almost my protector, I guess. It was my first Ryder Cup . He actually went to Billy Casper and said, hey let me take Larry. He's playing well. He's inexperienced but let me take him and so Billy said, Ido and so it actually had a great relationship after the '79 Ryder Cup matches. I mean he and I are both, I respected him prior to it and certainly had a lot of respect after
Fairways of Life: Tony Jacklin on the art of marquetry
Matt Adams interview 4-time Ryder Cup captain Tony Jacklin about his off course passion of marquetry.that I'm doing a special series of pictures for Right. Champions from Saint Andrews over the years. I just brought a couple with me. These will be on sale through the Links Trust website in the new year. This is Seve and I brought a Bobby Jones from Days gone by, and of course old Tom Morris who is the most synonymous, I suppose, professional from St. Andres. Ihave displayed around us. You have Old Tom. You have. You have Bobby Jones . You mentioned Old Tom and Young Tom, how many are in the series? Six. Initially, starting So, what were the other two that we've Wellness Jack. Oh. From 1970, of course and Tiger. I did and then there's father and son. Old Tom and young Tom. But the push, old Tom wasn't depicted quite as old as he was in the picture of done with them individual. But we're going to extend the series as we go. John Daily will be up in there.>> Yeah. And Zack Johnson and the like. And though I think there's somewhereI just tried to encapsulate in the pictures The essence of what Saint Andrews is about. The clubhouses in the back in the most cases, the Swilcan Bridge is in there, and you've got well in the Bobby Jones case, a wonderful picture of him with the Claret, just holding the Claret, smiling. Seve of course pumping the air as he
Griffin: Swing like Seve Ballesteros
Golf Channel Academy Lead Coach Fred Griffin shares a lesson for better tempo and timing he gave to Seve Ballesteros.Thanks for joining me on Golf Channel Academy. I'm your coach Fred Griffin. Today we're gonna work on helping you to improve your timing and tempo. I had a
Golfing World Player Profile: Greg Norman
Golfing World recently caught up with Greg Norman who spoke about Greg Normal Medal winner Jason Day and the healthy competition at the top of the game.the course, Norman believes it's equally vital for the stars of the PGA tour and the European tour to give back of the course as well. Based on what he seen so far from the current crop of fields, the


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Great new review of "Winter Light" from Germany's HIFI TEST: "…the concept is a complete success…Scott DuBois creates his music as a painter creates images." Read the full review in German under the "Aus Deutschland" section of the "Reviews" page!
Very nice review of "Winter Light" in JAZZIZ Magazine!: "From Rembrandt to Monet, artists have long sought to capture the essence of natural light. Now, guitarist and composer Scott DuBois takes up this painterly and poetic task through sonic expression…" See the "Reviews" page for a link to the full review!
NYC and Baltimore! Come hear the Scott DuBois Quartet this weekend, Fri., June 24th (9pm) at the Cornelia Street Cafe in NYC and Sat., June 25th (8pm) at An die Musik in Baltimore, MD!
More Scott DuBois Quartet music has just been added to the Scott DuBois YouTube channel! Subscribe to the channel at: youtube.com/scottduboismusic
Recently discovered video from a BET Jazz television broadcast of Scott DuBois' performance and interview from the 2005 Thelonious Monk Competition at the Kennedy Center in Washington D.C. To watch the video visit Scott DuBois' YouTube page at: www.youtube.com/scottduboismusic
Another great live review from the Scott DuBois Quartet's recent tour through Germany, this one in the Thüringische Landeszeitung newspaper! Visit the "Reviews" page "Aus Deutschland" section to read the review!
Winter Light has been named the #1 Jazz Album of 2015 by Poland's LongPlay!
Great live review of the Scott DuBois Quartet's recent performance at Jazz e.V. Dachau from the German newspaper, the Süddeutsche Zeitung: "Wonderfully subtle music…Impressionistic….tonal elegance…hypnotic…Winter as an aesthetic spectacle…excellent musicians…" See the "Reviews" page for a link to the full review!
Great "Winter Light" review in DownBeat Magazine: "startling and full-bodied, even rhapsodic…a joyous mini-symphony unto itself." See the "Reviews" page to read the full review!
Scott DuBois has just signed with the New Arts Agency in the Netherlands who will now handle his booking in the Netherlands, Belgium, and Luxembourg! Visit the New Arts Agency website at: www.newartsagency.com
Great review of "Winter Light" in the newspaper in Santa Fe, New Mexico, the Santa Fe New Mexican! See "Reviews" page for a link to the full review.
The Scott DuBois Quartet will tour Germany from March 3 - 10. See "Performances" page for details!
"Winter Light" has been named one of the best albums of 2015 by Germany's FONO FORUM Magazine and also by New York City's DOWNTOWN MUSIC GALLERY!
All About Jazz review of "Winter Light" calls the album "as wondrous, chilling, atmospheric, and powerful as can be." See the "Reviews" page for a link to the full review!
"Winter Light" has been named one of the "Albums of the Year" by the NEW YORK CITY JAZZ RECORD!
BR Klassik radio in Germany did a very nice radio feature on "Winter Light". You can find the link to hear the radio feature under the "Aus Deutschland" section of the "Reviews" page.
SOMETHING ELSE! reviews "Winter Light" and says, "Scott DuBois has painted a Monet." See "Reviews" page to read the full review!
Another great review of "Winter Light", this time from Spain's TOMAJAZZ. See the "Reviews" page for a link to read the full review!
"Winter Light" receives 5 (out of 5) Stars in the December issue of Germany's FONO FORUM Magazine!
"Winter Light" receives 5 (out of 5) stars and has been named "Album of the Month" in the November issue of Germany's STEREO magazine!
"Winter Light" receives a glowing review from AXS.com! See "Reviews" page for a link to read the entire review!
Great review of "Winter Light" on the CLASSICALITE site! See the "Reviews" page for a link to the full article!
Two great "Winter Light" reviews from the November issues of two Polish magazines: LONGPLAYRECENZJE and AUDIO
Great review of "Winter Light" in the Danish magazine JAZZ SPECIAL! See "Reviews" page for this and other reviews.
The "Winter Light" vinyl (2LP/180g) and CD are both now available for purchase on the "Discography & Store" page!
Great new "Winter Light" review from France's CULTURJAZZ.FR!
Great review of "Winter Light" by Norwegian journalist Tor Hammerø! Look for it posted soon under the "Reviews" section.
Great new reviews of "Winter Light" from Germany's JAZZ PODIUM, JAZZTHETIK, JAZZ THING, and KULTURNEWS magazines! They will soon be posted under the "Reviews" section.
Great new reviews of "Winter Light" from France's JAZZ MAGAZINE and JAZZ NEWS magazines! Look for these reviews soon under the "Reviews" section.
"…a brilliant work of art that touches the soul."
- Jazz Times (Steve Greenlee)
***** (5 stars) "Wonderful, evocative…a profound delight."
- DownBeat Magazine (Paul de Barros)
"Strumming, plucking and pulling strings as if he were rearranging them on the neck of his instrument…virtuosity…DuBois' tunes favor the upper end of the scale and intensify air that's already crackling with seriousness."
- AllAboutJazz New York (Jeff Stockton)
"Music as fluid and intriguing as a Dalì painting."
- AllAboutJazz New York (Terrell Holmes)
"(Scott DuBois) has begun to make waves…exploratory yet melodic sensibilities, serious compositional ambitions…cohesive looseness against complex subtleties…"
- The New York Times (Nate Chinen)


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Because it was decided that the two teams would compete separately. Originally, there were hopes for the two teams to not only march as one in the 2008 Olympics, but to compete as a single entity, a 'Korea' team. However, negotiations failed, and the two teams ended up marching separately as a result. Since then, there have been several diplomatic ...
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To determine if the use of metformin in people with prediabetes (impaired glucose tolerance or impaired fasting glucose) would prevent or delay the onset of frank type 2 diabetes mellitus.
MEDLINE was searched from January 1966 to the present, and articles meeting the selection criteria were hand searched.
Randomized controlled trials that involved administration of metformin to delay or prevent type 2 diabetes in individuals with impaired glucose tolerance or impaired fasting glucose were included. Development of diabetes was a required outcome measure; follow-up time of at least 6 months was required. Three studies met these criteria.
The 3 studies varied in ethnicity of the population studied, in the rates of conversion to diabetes from prediabetes, and in the dose of metformin used. In general the studies were well done, although 2 of the 3 did not do true intention-to-treat analyses. A sensitivity analysis was completed by converting all data to intention-to-treat data and assuming a worst-case scenario for the people who were lost to follow-up.
Metformin decreases the rate of conversion from prediabetes to diabetes. This was true at higher dosage (850 mg twice daily) and lower dosage (250 mg twice or 3 times daily); in people of varied ethnicity; and even when a sensitivity analysis was applied to the data. The number needed to treat was between 7 and 14 for treatment over a 3-year period.
Déterminer si l'utilisation de la metformine chez des pré-diabétiques (intolérance au glucose ou hyperglycémie à jeun) prévient ou retarde l'apparition d'un franc diabète de type 2.
On a consulté MEDLINE, depuis janvier 1966 jusqu'à aujourd'hui. Les articles répondant aux critères de sélection ont été repérés à la main.
On a retenu les essais cliniques randomisés qui comportaient l'administration de la metformine pour retarder ou prévenir le diabète de type 2 chez des sujets présentant une intolérance au glucose ou une hyperglycémie à jeun. Le développement d'un diabète était requis comme issue mesurable; le suivi devait être d'au moins 6 mois. Trois études répondaient à ces critères.
Les caractéristiques ethniques des populations étudiées, les taux de conversion de pré-diabète en diabète et les doses de metformine utilisées différaient dans les études retenues. Les études étaient généralement bien faites, quoique deux d'entre elles n'avaient pas utilisé une véritable analyse respectant le principe de l'intention de traitement. On a effectué une analyse de sensibilité en transformant toutes les données comme si elles respectaient le principe de l'intention de traitement et en supposant le pire scénario pour les sujets n'ayant pas complété l'étude.
La metformine a diminué le taux de conversion du pré-diabète en diabète. Cela était vrai aux fortes doses (850 mg b.i.d.) comme aux doses plus faibles (250 mg b.i.d ou t.i.d.); chez des personnes d'origines ethniques différentes; et même après analyse de sensibilité des données. Le nombre de traitements requis variait entre 7 et 14 pour un traitement d'une durées de 3 ans.
Type 2 diabetes is a worldwide epidemic. Prevalence has tripled in the last 30 years, and diabetes is predicted to affect more than 320 million persons by 2025. The concept of pre-disease, or at least the language of pre-disease, is relatively new. Pre-disease is the recognition that the upper limits of normal (what we used to call high normal or borderline) for measurements such as blood pressure and blood glucose might pose a health risk and might be a warning that a patient is progressing toward overt hypertension or diabetes.
Prediabetes includes the concepts of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). In 2005 Wen et al reported on an 11-year follow-up of 36 000 persons.1 Those with IFG (fasting glucose levels between 6.1 and 6.9 mmol/L) had significantly increased risk of mortality related to cardiovascular disease (CVD) and diabetes compared with people with blood glucose levels below 6 mmol/L. In a detailed review of the topic, Unwin and colleagues concluded that IFG and IGT (glucose ≥ 7.8 and < 11.1 mmol/L, 2 hours after ingestion of a 75-g oral glucose load) were strongly associated with CVD. Impaired glucose tolerance was more strongly associated with CVD than IFG was.2
A number of studies have looked at lifestyle and pharmacologic interventions in people with prediabetes to determine if progression to frank diabetes can be prevented. These studies were summarized in a meta-analysis published recently in the British Medical Journal.3 Researchers concluded that, in people with IGT, lifestyle and pharmacologic interventions (various antiobesity agents and oral hypoglycemic agents) are effective in delaying the onset of type 2 diabetes. They did not look at metformin individually, but instead included it with all other oral antidiabetic agents. Metformin is recommended as first-line treatment in diabetes; it is inexpensive compared with the newer drugs, and we believe that a review looking specifically at metformin is important.
The objective of this study was to determine whether the use of metformin in people with prediabetes (IFG or IGT) would prevent or delay the onset of frank type 2 diabetes mellitus.
MEDLINE was searched from January 1966 to the present for randomized controlled trials (RCTs) that focused on using metformin to treat prediabetes. The MeSH headings prediabetic state, glucose intolerance, and metformin were used. We also checked references of any articles and published reviews that used metformin to prevent type 2 diabetes. The search was not limited to English-language articles, but no articles written in other languages met the inclusion criteria.
Only RCTs were selected, in order to ensure inclusion of only high-quality evidence. Studies had to involve administration of metformin to delay or prevent type 2 diabetes in a sample or subsample of individuals with IGT or IFG. Development of diabetes was a required outcome measure; follow-up time of at least 6 months was also required.
Twenty studies were identified through the literature search. Of those, we excluded 17: 13 did not focus on the development of type 2 diabetes as a primary outcome measure4–16; 4 focused on inherent risk factors influencing diabetes progression, rather than on metformin use17–20; and 1 examined metformin use in combination with rosiglitazone.21 Hand searching of the references in the remaining 2 articles22,23 and the references in a recent systematic review of all treatment strategies for prediabetes identified a third article that met our criteria.24 In total, 3 studies were included in this review (Tables 1 and and2222–24).
Both authors reviewed the 3 articles independently. Although we were not blinded to the authors or citation sources of the articles, we were not familiar with the authors of any of the excluded or included articles. The critical appraisal process considered the validity of the methods, the strength of the results, the study populations, and how well the results could be applied to clinical practice. The methods and results are reported for the 3 studies in Tables 1 and and22.22–24
The study by Li et al enrolled 90 participants, 45 in each group.22 In their primary analysis, however, Li et al excluded patients from both groups if they did not comply with treatment (metformin or placebo), if they were lost to follow-up, or if they had gastrointestinal side effects. This left just 70 patients who were analyzed for outcomes in the primary analysis: 33 in the metformin group and 37 in the placebo group. The authors did perform what they referred to as an intention-to-treat analysis but still excluded the 5 participants (3 metformin, 2 placebo) who were lost to follow-up. They reported follow-up outcomes on those excluded for non-compliance and side effects but not on those lost to follow-up. We report on their primary analysis of 70 participants, but we also conducted an intention-to-treat analysis including the 5 participants who were lost to follow-up. We structured it as a worst-case scenario: the 3 participants in the metformin group were assumed to have developed diabetes and the 2 in the placebo group were assumed to have not. Our reanalysis of their primary analysis does not show a statistically significant difference as they reported. As expected, our intention-to-treat, worst-case-scenario sensitivity analysis also did not show a statistically significant difference.
The study by Ramachandran et al enrolled 531 participants randomly assigned to 1 of 4 different groups.23 We compared the metformin-only group with the usual care (control) group. No placebo was used in the control group, which meant that blinding patients to treatment was not possible. Of 129 participants enrolled in the control group and 136 in the metformin group, only 128 and 133, respectively, were available for follow-up and analysis. As in the study by Li et al, we carried out intention-to-treat, worst-case-scenario sensitivity analysis. The significant difference seen in the analysis reported in the study was still minimal in the sensitivity analysis.
The study by Knowler et al from the Diabetes Prevention Program (DPP) Research Group enrolled 3234 persons who were randomly assigned to 1 of 3 groups.24 We compared the placebo-controlled group (n = 1082) with the metformin group (n = 1073). This study appears to have been well done and was well reported; it also had a substantially larger sample size than the other 2 studies. The authors did an intention-to-treat analysis, meaning they included all those who were enrolled in the study in the assessment of outcomes. However, in order to have treated all studies equally, we decided to conduct a worst-case-scenario sensitivity analysis for this study as well. The authors did not report the actual number of participants lost to follow-up in each group. They did report that 99.6% of the full study population was alive at the end of the follow-up period. We assumed that this percentage was equally distributed across both groups and used this to calculate the number of people lost to follow-up in each group. We used these numbers in our worst-case-scenario analysis.
Four meta-analyses were performed. Figure 122–24 shows the results of the meta-analysis that includes the findings from all 3 studies as the authors reported them. Figure 222–24 reports on the results of the 3 studies when intention-to-treat, worst-case-scenario sensitivity analysis was used. Figure 322,23 reports on the 2 studies in which a lower dose of metformin was used (sensitivity analysis data). Figure 422,24 reports on the 2 studies that used a placebo control (sensitivity analysis data).
The meta-analysis of the results of these 3 studies as they were presented by the authors shows that metformin, used for up to 3 years, does decrease the likelihood that prediabetes will progress to diabetes (Figure 122–24). In order to counteract the potential bias caused by lack of intention-to-treat analysis in 2 of the studies and the effect of patients who were lost to follow-up in all of the studies, we conducted a sensitivity analysis. We restructured the numbers to reflect a true intention-to-treat scenario (we included all patients enrolled in each study in the results calculations for each study) and a worst-case scenario, in which those lost to follow-up in the intervention groups were assumed to have progressed to diabetes and those lost to follow-up in the control groups were assumed not to have progressed to diabetes. Even when stacking the odds against a significant effect, the meta-analysis still showed that metformin decreased the likelihood of progression to diabetes (Figure 222–24). We also performed 2 other meta-analyses. The first included only the 2 studies where a lower dose of metformin was used (Figure 322,23) and revealed that the lower dose also had a significant effect, at least in the ethnic subgroups (Indian and Chinese) in which these studies were conducted. The other meta-analysis included only the 2 studies where a placebo (Figure 422,24) was used in control groups; this also showed a significant effect of treatment.
We also calculated the numbers-needed-to-treat (NNTs) for these 4 meta-analyses. For the meta-analysis in Figure 1,22–24 the NNT is 12 (95% confidence interval [CI] 9 to 21); for the meta-analysis in Figure 2,22–24 the NNT is 12 (95% CI 9 to 22); for the meta-analysis in Figure 3,22,23 the NNT is 7 (95% CI 4 to 32); for the meta-analysis in Figure 4,22,24 the NNT is 14 (95% CI 9 to 27). All of these meta-analyses are dominated by studies that followed patients for 3 years; hence the NNTs apply to treatment over a 3-year period.
It is important to note the variation in overall rates of progression to diabetes in these 3 groups. The study conducted in China22 had an overall rate of conversion to diabetes of 10%; the study in India23 a rate of 48%; the DPP study,24 in which ethnicity was mixed (55% white, 20% African American, and only 5% Asian), a rate of conversion to diabetes midway between the other 2 studies at 24%. This fits with the recognized higher prevalence of diabetes and metabolic syndrome in people of South Asian decent.
It is difficult to know from this review whether the relative effectiveness of the lower dosage of metformin (250 mg twice or 3 times daily) compared with the higher dosage (850 mg twice daily) used in the DPP study would hold true for all people. The 2 studies that used lower dosages were conducted in China and India, where conversion rates to diabetes are different from that in the study using the higher metformin dosage. In the 2 studies that used lower dosages, only the Indian study (in which the overall conversion rate was much higher) showed a statistically significant difference in rates of conversion between treatment and control. It is possible that the effectiveness of the lower dosage is somehow related to genetics or ethnicity.
The main limitation of this paper is the difficulty of applying the results to clinical practice. The studies do show that patients with prediabetes who take metformin are less likely to have blood glucose levels in the diabetic range after 3 years. It is possible, however, that this is simply a treatment effect and not a prevention of progression at all. It is likely because of this possibility that most primary care physicians are not yet prescribing metformin for their patients with prediabetes, but using lifestyle treatment instead. It is also probably because of this possibility that guideline-generating groups are not yet recommending that prediabetes be treated with metformin as a matter of course.
Whenever a systematic review is conducted, there is the possibility of missing important published articles and unpublished data. Our search of MEDLINE was exhaustive, and it is unlikely we missed any RCTs indexed in that database. It is possible that other databases, such as EMBASE, might have indexed articles that were not included in MEDLINE. Our hand checking of references in the articles we retrieved and the huge overlap between MEDLINE and EMBASE makes it unlikely that an important published article was missed. We did not approach investigators working in the field to see if they had unpublished data that met our criteria. The possibility of unpublished data exists, but we believe this possibility is remote because a randomized trial of sufficient power and quality to have met our inclusion criteria would have been expensive to complete and publication would, in all likelihood, have been sought.
There is uncertainty about the effect of metformin: is the effect seen in these studies a treatment effect or a preventive effect? A study of sufficient power needs to be conducted that duplicates the effects of metformin shown in these studies; that study then needs to switch both groups to placebo to see if the benefit disappears within a few weeks in the group that previously had metformin. If the effect disappears it would mean we are simply seeing a treatment effect—that is, the metformin was keeping the blood glucose in the nondiabetic range rather than slowing the course of diabetes.
It seems that, even when applying a worst-case-scenario sensitivity analysis, the effectiveness of metformin on rates of conversion from prediabetes to diabetes remains. The NNT for treatment over a 3-year period is between 7 and 14. This compares very favourably with many other treatments and on a population basis could have an important effect on diabetes and its complications. It is probably best to use a metformin dosage of 850 mg twice daily except in people of South Asian descent, for whom this dosage might be higher than needed and might lead to side effects.
Cet article a fait l'objet d'une révision par des pairs.
Competing interests
None declared
Ms Lilly and Dr Godwin contributed to concept and design of the study, the literature review, selection and analysis of the studies, interpretation of the analysis, and preparing the manuscript for submission.
This article has been peer reviewed.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Top Flite Kids' XLj Putter (Height 53'' and above)
Product Information:
The XLj Putter is designed for kids ages 9-13 or with a height ranging of 53'' or greater. This putter has a mallet-shape design with an oversized head for increase forgiveness. It also has alignment lines, helping junior golfers easily visualize a putting line to the hole. The Top Flite XLj Putter is the perfect piece of equipment to round out a youth set of golf clubs.
- Designed for junior golfers ages 9-13 or with a height of 53'' and above
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- Mallet shape putter has an oversized head for more forgiveness
- Alignment lines help to easily visualize a putting line to the hole
- Junior sized rubber grip features an integrated design to teach hand position for a correct grip
- Top Flite
Country of Origin: ChinaWeb ID: 19616626


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Acer Iconia A500 Android tablet
Acer Iconia A500 review: An Android 'Honeycomb' tablet with USB and HDMI-out ports
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DEMOfest is an annual technology showcase of leading Informatics and Computer Science research from Scottish Universities and creates an environment for industry partners and academics to come together and identify opportunities for:
- Collaborative Innovation
- Studentships & Placements
- Technology Licensing & Consultancy
- Feasibility & Proof of Concept Studies
The 2016 edition of DEMOfest will take place on 11th November 2016 from 5.30pm at the Technology and Innovation Centre, University of Strathclyde. More information will follow shortly.
A number of two-minute research-pitch videos from the 2015 event are available on our video wall.
View research projects from recent DEMOfest Exhibitions: SICSA DEMOfest 2015; DEMOfest North – February 2014 or download pdf; DEMOfest 13 – November 2013 or download pdf


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Advantage, America
What Obama Should Do at the North American Leaders' Summit
Interviewees: Allan H. Meltzer
Martin N. Baily
Interviewer: Roya Wolverson
January 29, 2010
In response to high unemployment and the public's growing frustration over the ballooning U.S. deficit and sizeable bank bonus payouts, Obama has added several economic proposals to Congress' docket of ongoing financial regulatory reforms. These include plans to tax banks' excessive risk-taking, ban proprietary trading, cap the government's discretionary spending, and help the middle class.
Allan Meltzer, professor of political economy at Carnegie Mellon University, says these proposals are mostly "cosmetic," and do more to address Obama's "concern for building a constituency for the election" than to fix economic problems.
Martin Baily, a senior fellow at the Brookings Institution and former chairman of the Council of Economic Advisers, says that although Obama's bank tax probably will not work, it would be nearly impossible for him to propose deeper spending cuts without losing either Democratic or Republican support.
The reappointment of Federal Reserve Chairman Ben Bernanke on January 28 also divided lawmakers and economists, despite the White House's strong support for the move. Although Meltzer commends Bernanke for his creativity and decisiveness in responding to the financial crisis, he also argues that Bernanke overstepped his role, jeopardizing the Federal Reserve's independence and putting the country at risk of inflation. By contrast, Baily says considering the magnitude of the crisis, anyone in Bernanke's position would have made mistakes, but overall his performance has been "terrific."
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Kurlantzick offers the sharpest analysis yet of what state capitalism's emergence means for democratic politics around the world. More
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What Obama Should Do at the North American Leaders' Summit
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Dallas Stars general manager Joe Nieuwendyk said Thursday that he was told that Brad Richards will not waive his no-movement clause and will become a free agent July 1.
"That's their right, but it's frustrating from our end. But what can you do, right?" Nieuwendyk told ESPN.com of his discussion with veteran agent Pat Morris. "We'll just turn the page. But it's real disappointing."
Nieuwendyk had rolled the dice and decided not to trade Richards in March, who led the Stars with 77 points. The center now becomes an unrestricted free agent and could have as many as 10 teams interested.
The Stars likely will have to watch their star player walk away without receiving compensation.
Pierre LeBrun covers the NHL for ESPN.com.


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Matching Healthcare Solutions with Delivery Experience...
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Ultraorphan drug development is still challenging. However, some of the emerging business models may change the industry outlook on ultraorphan drugs. The inventors and adapters of these innovative business models include not-for-profit as well as for-profit companies, pharmacies, and patient-support groups.
While the for-profit business model based on high-prices has become the norm of the sector, novel approaches are being adopted in the emerging ones. For instance, the Institute for One World Health, a not-for-profit company focusing exclusively on neglected diseases, works on a hybrid business model combining philanthropic funding with the revenues from commercial activities such as partnership projects and intellectual property licensing.
Another model is patient-support groups as investors. A typical example is the Cystic Fibrosis Foundation Therapeutics, which is promoting cystic fibrosis drug development by acting as a virtual company based on a venture philanthropy business model.
Specialty pharmacies dedicated exclusively to ultraorphan drugs are also emerging, which is proving to be beneficial for patients as well as companies. While the patients receive a full package of services that include safe and timely delivery, payment, reimbursement, and financial assistance, the companies benefit by improved patient access that assists in patient monitoring and price designing.
ODA has attracted considerable negative media coverage lately. The controversy over the price increase and the availability issues associated with H.P. Acthar Gel (ACTH) is a representative case. In 2007, after receiving orphan drug status for the treatment of infantile spasms, the price of ACTH was increased by over 10 times and its availability was controlled by limiting the number of distributors.
Since the drug was in the market for decades for treating various indications, payers, as well as patients categorized these actions as loopholes of ODA. Critics also have criticized the practice of defining patient groups in a narrow manner to get orphan drug status.
Overall, however, it has to be acknowledged that ODA was instrumental in providing treatments for various rare diseases, which would have received little attention from the industry otherwise. Hence, though loopholes exist, ODA can be rated as a regulation successful in meeting its objectives to a significant extent.
Syamala Ariyanchira, Ph.D. ([email protected]), is the author of BCC's Global Markets for Orphan Drugs. Web: www.bccresearch.com.
Syamala Ariyanchira, Ph.D. ([email protected]), is the author of BCC's Global Markets for Orphan Drugs. Web: www.bccresearch.com.
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Add these shoulder exercises into your regular workout routine and increase your upper body strength, while strengthening and stabilizing your shoulders. From the stability ball dumbbell press to the medicine ball push-up, these exercises are a great way to strengthen your deltoids, rotator cuff and trapezius muscles. Browse through our large collection of detailed tutorials and step-by-step demonstrations from today's leaders in the health fitness industry. For full workout routines featuring these shoulder exercises, visit our Workouts section.
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It's estimated that over 20 million people in the U.S. practice yoga, and this number is growing every day. Yoga classes typically combine stretching and poses with breathing techniques, and serve as a wonderful way for people to de-stress and move their bodies. Yet this...


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Clinical Investigations
Kidney Function and Mortality in Octogenarians: Cardiovascular Health Study All Stars
Version of Record online: 21 JUN 2012
DOI: 10.1111/j.1532-5415.2012.04046.x
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 7, pages 1201–1207, July 2012
Additional Information
How to Cite
Shastri, S., Katz, R., Rifkin, D. E., Fried, L. F., Odden, M. C., Peralta, C. A., Chonchol, M., Siscovick, D., Shlipak, M. G., Newman, A. B. and Sarnak, M. J. (2012), Kidney Function and Mortality in Octogenarians: Cardiovascular Health Study All Stars. Journal of the American Geriatrics Society, 60: 1201–1207. doi: 10.1111/j.1532-5415.2012.04046.x
Publication History
- Issue online: 12 JUL 2012
- Version of Record online: 21 JUN 2012
- Abstract
- Article
- References
- Cited By
- octogenarians;
- kidney function;
- mortality
To examine the association between kidney function and all-cause mortality in octogenarians.
Retrospective analysis of prospectively collected data.
Serum creatinine and cystatin C were measured in 1,053 Cardiovascular Health Study (CHS) All Stars participants.
Estimated glomerular filtration rate (eGFR) was determined using the Chronic Kidney Disease Epidemiology Collaboration creatinine (eGFRCR) and cystatin C one-variable (eGFRCYS) equations. The association between quintiles of kidney function and all-cause mortality was analyzed using unadjusted and adjusted Cox proportional hazards models.
Mean age of the participants was 85, 64% were female, 66% had hypertension, 14% had diabetes mellitus, and 39% had prevalent cardiovascular disease. There were 154 deaths over a median follow-up of 2.6 years. The association between eGFRCR and all-cause mortality was U-shaped. In comparison with the reference quintile (64–75 mL/min per 1.73 m2), the highest (≥75 mL/min per 1.73 m2) and lowest (≤43 mL/min per 1.73 m2) quintiles of eGFRCR were independently associated with mortality (hazard ratio (HR) = 2.49, 95% confidence interval (CI) = 1.36–4.55; HR = 2.28, 95% CI = 1.26–4.10, respectively). The association between eGFRCYS and all-cause mortality was linear in those with eGFRCYS of less than 60 mL/min per 1.73 m2, and in the multivariate analyses, the lowest quintile of eGFRCYS (<52 mL/min per 1.73 m2) was significantly associated with mortality (HR = 2.04, 95% CI = 1.12–3.71) compared with the highest quintile (>0.88 mL/min per 1.73 m2).
Moderate reduction in kidney function is a risk factor for all-cause mortality in octogenarians. The association between eGFRCR and all-cause mortality differed from that observed with eGFRCYS; the relationship was U-shaped for eGFRCR, whereas the risk was primarily present in the lowest quintile for eGFRCYS.


text: Obama Election Day Photo Op FailPareene11/04/08 9:45amFiled to: horse raceBarack Obamaelection dayVotingCampaignsDrudgeHeadlineshillary clintont72EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalink According to Drudge, Barack Obama and his wife Michelle have taken "more than 15 minutes to vote." Maybe they're undecided? His link goes nowhere. Ben Smith doesn't report anything about how long it took Barack Obama to vote. Meanwhile: "HILLARY POLITICKING INSIDE NY POLLING AREA, ADVOCATES FOR OBAMA, 5 FEET FROM BOOTHS... DEVELOPING... " Once again, no link! But this is really a "fuck you, too late to not vote for me" move by the Obamas. Look who else voted at their polling place: Among the other voters who have shown up to vote at Shoesmith Elementary School this morning, where Sen. Barack Obama, D-Ill., will vote: Louis Farrakhan and William Ayers. He's palling around with a domestic terrorist and a radical black person ! The real Barack Obama is revealed at last! It's not too late to vote for the white guy, America! Unless you voted early! Curses! Reply72 repliesLeave a reply


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13 Colonies
Now that England is settling in North America more, we have thirteen colonies. The colonies are all set up for different purposes. They are divided into the New England, middle, and southern colonies.
The Puritans control Parliament. They have formed the Massachusetts Bay Company, and have come to America. They've settled in a city called Boston, and the colony is Massachusetts. Massachusetts is...
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...were two colonies with England settlers, these colonies were very different. New England economy was base on growing crops and livestock, unlike the Chesapeake who depended greatly on the king of England for economic support. The New England colony who came to the new world for religious freedom practiced Christianity. On the other hand Chesapeake colony was mostly from the Anglelican church who at the time were actually a ruling...
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...English colonies were one of three types of colonies. The first being a joint-stock colony. In this type of colony the king of England would grant a charter to a joint-stock company that would ensure settlers the same rights as Englishmen. Joint-stock colonies were only meant to last a few years. After which, stockholders hoped to earn a profit. Many people were attracted with the promise of gold. The second type was a...
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...the American Colonies were established. The three most important themes of English colonization of America were religion, economics, and government. The most important reasons for colonization were to seek refuge, religious freedom, and economic opportunity. To a lesser degree, the colonists sought to establish a stable and progressive government.
Many colonies were founded for religious purposes. While religion was involved with all of the...
1054 Words |
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...New Colonies in New England
¶1 New England started as one large colony settled by two different religious groups. In 1620, the Pilgrims came from England on the Mayflower and started a colony in Plymouth Bay. The Puritans arrived in 1629 and started the Massachusetts Bay Colony.
¶2 The Pilgrims had a charter promising them land in Virginia, but on the trip across, their ship blew off course. Unfortunately, they were unprepared for life...
995 Words |
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...Geography was the primary factor and played an important role in shaping the development of the British colonies in North America. In some areas, the geography influenced the living and farming conditions for the better, and for some areas, for the worse.
The Southern colonies' geography was well-suited to farming. It was warm year round and provided a great place to produce cotton, indigo, rice, and many other crops. However they had few natural harbors....
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...similarities between colonies. During the colonial time period from about the 1600's through the 1700's, the thirteen original colonies were founded and divided among three major sections known as the New England colonies, the Middle colonies, and the Southern colonies. The New England colonies consisted of Massachusetts, Rhode Island, Connecticut, and New Hampshire. The Middle colonies...
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Why you should settle in the Middle Colonies?
From Delaware to New Jersey, New York to Pennsylvania, there is this wonderfully diverse colony. This is the place you will want to get married, have children, and basically grow old in. This is the bread basket colony . This is the Middle colonies. This is the Quaker land, where you can randomly give complete strangers a ride....
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Depending on the type of league you play in, goaltenders are solely responsible for anywhere from 30-50 percent of the categories. That's not news to you, though. That's why on draft day you invested in an anchor goaltender; someone who could be your real No. 1 in net. You took care of those categories by drafting Marc-Andre Fleury, Kari Lehtonen, Martin Brodeur, Chris Mason, Vesa Toskala, Ray Emery or Peter Budaj.
I'll pause now to allow you to bang your head on your desk a few times.
Now, I'm sure some of the above names will suit just fine this season and turn things around for you, but some of them won't. Reliable goaltending is essential to winning a fantasy hockey league. Look at the leaders in your league; I'll bet in most cases they have top-three goaltending statistics. If you invested in a Lehtonen, Toskala, Emery or Fleury, you need to act now.
Casing the Joint
No one wants to part with good goaltending. It's not news to anyone that goaltending is essential to winning. So the trick is getting someone to part with what is widely viewed as one of the most valuable commodities in fantasy hockey.
The first step is to find someone who is more likely to part with a goaltender. That should be relatively easy. Just look at who owns some of the surprise goaltenders this season. Whoever drafted Pascal Leclaire, Martin Gerber and Tim Thomas wasn't expecting much when they picked them up. Those goaltenders were their Plan C in the draft. One particular owner in one of my leagues was fortunate enough to draft both Thomas and Gerber as backups to Rick DiPietro and Niklas Backstrom. I'm sure he would have no issues with parting with a goalie for more offense. Double-check to make sure your potential target has been doing well in the goalie categories; they'll be more likely to part with a 'tender if they have been running away with wins, goals-against average and save percentage.
Next, you have to decide which goaltender you are targeting. Thomas has been a hero for the Bruins and his fantasy owners this season, but if you are going to invest in a goaltender, do you really want to trust him? There are just too many downsides to Thomas (Manny Fernandez, no track record for this performance, bad with rebounds) to really trust him as a solid investment to right your ship. In fact, track record should be one of the first things you look for. I'm going to break away from strategy for a moment and list what I believe are the best goaltenders to target to help fix your ailing squad.
Miikka Kiprusoff, G, Flames: Kipper is a perfect target to help buoy your goalie stats. Even though his save percentage is well below where it should be, his wins and goals-against average are just fine. Coach Mike Keenan's focus on offense and the loss of Roman Hamrlik are partly to blame for his sub-.900 save percentage, but things will get better. Kipper just needs to adjust to having a defense that doesn't consistently rival the best in the NHL. Even if he doesn't come around, pairing him with another goalie that has a strong save percentage makes up for his only shortcoming.
Cam Ward, G, Hurricanes: Ward worked on his conditioning all through the summer, and it is showing in spades this season. His glove is exceptionally sharp, and his numbers are reflecting the improvements. Ward's numbers are slightly above average right now, but I don't think they represent just how good he will finish this season. Many owners will still see him as a strong No. 2 goaltender, but as Carolina continues to roll, he'll turn in No. 1 numbers.
Ilya Bryzgalov, G, Coyotes: His brief Phoenix résumé is quite exceptional, and anyone who scooped him up when he was waived is likely in a position to try to deal him while the getting is good. Take them up on their plan. The Coyotes have a lot of problems, but defense is not one of them. Bryzgalov will get all the help he needs to continue to meet the lofty expectations he has already set in the desert.
Martin Brodeur, G, Devils: The window is still open to pay slightly less than you should for the best fantasy goaltender. Brodeur got over the hump of his 500th win and is on a roll that could well last into April. I have no concerns about paying a little extra and going after Brodeur.
Olaf Kolzig, G, Capitals: With a coaching change in Washington, I expect they will quickly climb out of the NHL's basement and leave Edmonton as the front-runner for the best draft lottery odds (incidentally, the pick belongs to Anaheim). Kolzig's numbers have been just fine, and the lack of wins have been the only real problem with depending on him. Expect a turnaround, and target him as a strong No. 2 goaltender if your situation right now isn't dire.
You'll notice the theme is "goaltenders that are undervalued." Of course you can go and pay out the nose for an Evgeni Nabokov or a Henrik Lundqvist. That will solve your problem, but will cost you more than it's worth.
The next step in fixing your problems in net is admitting to yourself you have a problem and realizing that trading for a goaltender is going to cost you. It's going to cost you a top-25 forward. That is an approximation of what the going rate for a goalie is. You are going to have to part with a Martin St. Louis or a Ryan Getzlaf. Once the season gets started, the value of goaltenders skyrockets. I've said it before, and I'll say it again: One of these days, goalies in hockey will be drafted like running backs in football. The process of acquiring one means you have to come to terms with the fact that it's going to cost you. You should try to get away with paying less, but be prepared to pay the price.
To finalize a deal, ask what your potential trading partner needs on their team without tipping the fact that you are after a goaltender. If you can identify a weakness they see that you can help fix, putting together the deal should be easier. It's also helpful to try to keep the deal positionally equal; meaning you toss in a lesser goaltender and ask for a weaker forward back. Even-keel deals are more appealing to other owners, and you want to keep them happy.
Pulling the Job
I needed some help in one of my leagues after taking Fleury as my No. 1 and backing him up with a skeleton crew of Cristobal Huet, Carey Price, Josh Harding and Jose Theodore. Fleury's failure and the juggling act of using four part-time goalies became too much. I needed a reliable No. 1 goaltender.
I targeted Kiprusoff, mainly because I have faith in him rising through the goaltending ranks over the next month or so as he gets more used to Keenan's new defense. My trading partner had a weakness down the middle and on the right wing, but he also had some high-upside players in those positions. After a couple of back-and-forths, I managed to get Kiprusoff, Brad Richards and Marian Gaborik for Martin St. Louis, Scott Gomez, Huet and Price.
My goaltending problem is solved (as I continue to believe in Fleury) and I didn't lose much, if anything, on offense.
Sean Allen is a fantasy baseball and hockey analyst for ESPN.com. You can Email him here.


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I try to set up Postgres for rails in order to be able to deploy on Heroku. I am actually resuming rails tutorials and am a bit lost (am no programmer)
In PgadminIII I try to connect to the single server available (POSTGRESQL 9.3 Localhost 5432)
It asks for a password (which I am guessing at the moment) and shows error:
server doesn't listen
My questions are:
- Is the password the super user password? (the only one I own at the moment)
- what is the purpose of the super user password?
- How can I recover the password that activates the server?


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