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HARRISBURG, June 30 – State Rep. Rob Matzie, D-Beaver/Allegheny, today supported the passage of a state budget plan that funds education at record levels, without a broad-based tax increase.
"While I will be the first to admit that this budget isn't perfect, it is a solid step in the right direction especially for our schools and students," Matzie said. "After the protracted impasse of last year, it is refreshing to see this compromise, especially as it contains historic education funding but doesn't add to our structural deficit."
Senate Bill 1073 includes a $250 million increase for pre-K through 12 education funding, including $200 million for K-12, $30 million for pre-K and Head Start, and a $20 million increase for special education.
"The spending plan that's now on its way to Governor Tom Wolf is a workable compromise that will invest in our state without relying on a sales or income tax increase," Matzie said.
Matzie said the bill also would provide funding for three additional Pennsylvania State Police cadet classes; transfer millions from the Oil and Gas Fund to the General Fund to give money to conservation programs, Growing Greener, and the Hazardous Sites Cleanup Fund; and dedicate $15 million to combat heroin and opioid addiction, including funds for emergency addiction treatment and behavioral health services.
Read more
State Rep. Rob Matzie, D-Beaver/Allegheny, joined Gov. Tom Wolf, state and local elected officials, labor leaders, business leaders and education officials Thursday at Penn State Beaver for a roundtable discussion on how Beaver County's workforce and infrastructure can prepare for the construction of the Shell ethane cracker plant expected to deliver thousands of construction jobs and thousands of operational and ancillary jobs to the region. Read more
Pa. state Rep. Rob Matzie took part in Governor Tom Wolf's roundtable discussion in Beaver County Thursday. State and local leaders discussed the changes needed as Shell builds a massive petrochemical plant in the coming years including educating the local workforce and infrastructure improvements. Read more
HARRISBURG, July 1 – State Rep. Rob Matzie, D-Beaver/Allegheny, said a grant for more than $100,000 today was awarded to Allegheny Petroleum.
The $116,454 Multimodal Transportation Fund grant will be used by Allegheny Petroleum to expand its facilities in Ambridge and perform needed upgrades.
"This grant will not only allow Allegheny Petroleum to move more of its products efficiently over rail, it will also improve the safety of that rail activity," said Matzie. "This investment in the rail infrastructure of Beaver County will undoubtedly lead to increased economic activity for the region and an improved quality of life for our communities."
The Multimodal Transportation Fund, which was created by the transportation funding plan, provides grants to encourage economic development and ensure that a safe and reliable system of transportation is available to Pennsylvania residents.
The grant was approved by the Commonwealth Financing Authority, an independent state agency that evaluates and administers funding for projects that create jobs and improve cultural and recreational assets.
Read more
Pa. state Rep. Rob Matzie asks the Federal government to lift the ban on sports betting and allow certain states to regulate it through their own licensed casinos. Read more
HARRISBURG, June 29 – The state House of Representatives today adopted a resolution sponsored by state Rep. Rob Matzie, D-Beaver/Allegheny, that urges the federal government to lift the ban on sports betting.
"Just last week, the National Hockey League announced the awarding of a franchise to the City of Las Vegas," Matzie said. "This shows just how drastically public opinion and policy has shifted over time and should deliver the killing blow to the notion that professional athletics cannot coexist with legal sports wagering."
House Resolution 619, which was adopted by a vote of 140-59, urges Congress to repeal the Professional and Amateur Sports Protection Act of 1992 which prohibits sports betting in every state except Nevada, Oregon, Montana and Delaware.
"Pennsylvania responsibly oversees and regulates various forms of gaming throughout the state including the lottery, slot machines and horse racing. But an arbitrary law, which hasn't been revisited by the federal government in more than two decades, prevents us from seriously considering sports betting," Matzie said. "While discussions would be needed about how sports betting would work in the Pennsylvania, I think it verges on ridiculous that the federal government would prevent us from even exploring the option."
If the federal government lifts the ban, any state with authorized, license and regulated casino gaming would have the authority to legalize sports betting at its licensed facilities.
"I would f Read more
HARRISBURG, June 23 – State Rep. Rob Matzie, D-Beaver/Allegheny, joined Gov. Tom Wolf and a group of bipartisan legislators today for a Capitol news conference to highlight details of a joint effort to combat the opioid and heroin crisis in the state.
In the Rotunda, Democratic Leader Frank Dermody joined Speaker of the House Mike Turzai, Majority Leader David Reed and other House members to announce the completion of recommendations from the Task Force and Advisory Committee on Opioid Prescription Drug Proliferation.
"For the past several years, the General Assembly has been focused on the opioid and heroin crisis gripping our state," Matzie said. "While there is still much to do to wipe this scourge from our communities, today represents progress in that fight. The recommendations from the task force will make a real difference in ending this crisis."
The Task Force and Advisory Committee on Opioid Prescription Drug Proliferation, which was created through the adoption of a resolution in 2014, made several legislative recommendations, including H.B. 1737 and H.R. 590, both of were recently approved by the House. Also announced at the news conference was a special legislative session focused on the opioid crisis, which is expected to be convened in September.
"This issue isn't a partisan one. Individuals from all across our state and from all walks of life have fallen victim to addiction," Matzie said. "As a member of the Health Committee, I have seen members from bo Read more
It's the big head-scratcher in the Pennsylvania Capitol.
House Democrats this month helped pass bills that advanced a couple long-sought Republican priorities — scaling back traditional public pension benefits and breaking state-control over wine sales — apparently without any assurance that the Legislature's huge GOP majorities will return the favor to Democratic Gov. Tom Wolf.
With less than two weeks until the fiscal year ends, the question now is what Wolf will get from tax-averse Republicans to advance his efforts to wipe out a damaging deficit and close huge funding inequities between wealthy and poor school districts.
"We're negotiating with them," said House Minority Whip Mike Hanna, D-Clinton. "That's probably the biggest thing in the world. I mean, at this point last year, (House Republicans) had told us we weren't in the room, that they were going to pass their budget with no Democratic input."
Wolf and lawmakers spent much of the last year mired in a bare-knuckled partisan fight over Wolf's first budget, an embarrassing crisis that all sides seem determined to avoid repeating, particularly in an election year.
Read more
HARRISBURG, June 15 – The Pennsylvania House of Representatives unanimously adopted a resolution authored by state Rep. Rob Matzie, D-Beaver/Allegheny, that would designate the week of June 20-26 as Pollinator Week in Pennsylvania.
Matzie's resolution is intended to highlight the necessity of pollinators, including birds, insects and especially bees, both in the ecosystem and for the security of the food supply.
"Many types of birds and insects, in particular bees, are essential partners for farmers in the commonwealth and across the globe," Matzie said. "My resolution also recognizes the important role beekeepers play in the pollination process, which enables the production of many of the foods produced in Pennsylvania's agriculture industry."
Matzie's resolution recognizes the state's Bee Law, which provides conservation assistance for the protection and maintenance of pollinators and their habitats through the Department of Agriculture.
"Our pollinators also play a vital role in preserving the health of our national forests and grasslands, which provide fish, wildlife, timber, water, mineral resources and recreational opportunities," Matzie said. "It is clear to me that without our pollinators, the commonwealth would be a very different place."
It also notes the work of the Pollinator Partnership, a nonprofit organization that protects the health of native pollinating animals vital to North American ecosystems; the Pennsylvania State Beekeepers Association; the D Read more
HARRISBURG, June 8 – State Rep. Rob Matzie, D-Beaver/Allegheny, applauded Gov. Tom Wolf today for promptly signing legislation into law that will modernize and expand retail sales of wine and liquor in Pennsylvania while preserving jobs.
House Bill 1690, which passed the House yesterday with a vote of 157-31, will allow wine to be sold in many more locations, including grocery stores that already sell beer, give more flexibility to the Liquor Control Board to set prices and store hours across the state, and permit direct shipment of wine by licensed producers to consumers at their homes.
"Finally the people of Pennsylvania will be able to enjoy the same conveniences they would expect from any modern business when they are shopping for wine and liquor," Matzie said. "While this bill is far from perfect, it is a good first step that gives the people what they really want: convenience, without sacrificing thousands of well-paying jobs."
Matzie said the law, which is expected to generate up to $150 million a year in new revenue for the commonwealth, will also protect nearly 5,000 family-sustaining jobs.
"This legislation will give the LCB flexibility in terms of pricing and store hours, including the authority to open more of their stores on Sunday. These changes will bring our state store system into the 21st century and may even result in the creation of additional jobs," Matzie said. "I applaud Governor Tom Wolf for his quick action on this bill, and I hope this moment Read more
The York Dispatch reports on Rep. Matzie's bill to make it illegal for third parties to sell driver and vehicle records obtained through PennDOT. Read more
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Battleship (2012)
out of this world!
The special effects are incredible ! This movie has it all , action explosions ! And robots , who could ask for more from an action movie ! If you like intense hi-tech computer graphics ,and inter galactic battles. Between man and machine , than this movie is the one to see ! But if you like good old shoot em' up movies, like Rambo or Die Hard . Than this movie isn't for you ! I haven't seen the block buster yet but it looks amazing ! A definite must see for the big screen ! For the technology and intense high pulse rush alone ! I would give it an A +! It looks like one of the best, movies out there by far this year ! And that is no lie , I have seen a lot of movies of this genre ! This movie surpasses them by far !
Twilight (2008)
conflicted heart
I have seen this coming of age story, about a young woman who seemed to have an ordinary life. Trying to find herself, and fit in to the new town. Until she met the brooding young man and now she is stuck in middle of a sorted. Triangle between a werewolf and a vampire! And which one her heart will choose, though I haven't read the books. As of yet, I still found the movie to be bittersweet yet romantic ! I can not wait to see how this saga, between Edward , Bella and Jacob. Will end , I would recommend this movie who anyone who enjoys a good love story. But if you want to see a movie with a little bite. With no romantic undertones . Than this movie isn't for you! I would give it an A !
Kung Fu Panda (2008)
This Kung Fu panda kicks butt !
This cartoon was funny from the start,all the way to the end.I love it,because there were no people in it. Po was my favorite character,because he reminds me of our cat;all he wanted to do was sleep and eat. This was my mom's take on this hilarious cartoon! About a comical but lovable panda. Who later became the Dragon Master ! Mine was I too loved it I laughed from beginning to end ! It was that funny , I mean who would ever think a chubby lazy panda. Could become a savior to an entire village is quite humorous! We can't wait to see the sequel ! If it is anything like this one ,it will be just as funny! Jack Black , was a great choice for the voice of Po ! It made it even funnier!
The Nightmare Before Christmas (1993)
have yourself a very scary Christmas
Once upon a time there was a town called Halloweentown ! Where everything is Halloween, all year around ! Then Jack Skelington the Pumpkin king of this dreary and creepy little town. Had a wonderfully awful idea why not, celebrate Christmas and make it ours. There in lies the title , The Nightmare Before Christmas. A dark and gloomy spin on the classic poem. 'Twas the Night Before Christmas', that only Tim Burton himself could deliver! Such a twisted tale,of meshing Christmas and Halloween together as one! In this hauntingly delightful musical. About kidnapping Father Christmas, and putting his own spin on the holiday! But his plan takes a frightful turn for the worse, when the toys he created terrify and turn on the little kids! All of that sinister planning of his crashed and burned! My favorite character was Sally , a kind hearted rag doll held captive by a mad scientist! Who in the end won over the black hearted Jack! I love this this movie ! It combines two of my favorite holidays together. In a off color
sort of way!
Mary Reilly (1996)
Dr. Good and Mr.Evil
The movie Mary Reilly, is the tale about good and evil. And how the two tore apart the soul of one man,driving him to madness.This man was a doctor by day and a killer by night.He was a healer of man loved by all who knew him.And at night he was someone that was feared by all that he meant a long the streets.He would have black outs and could not remember what he did at all.He killed many people, got away with it for a long time because; his other half would hide him in the darkness of his mind. Julia Roberts (aka Mary Reilly) played the part very well. I loved this movie because,I feel torn between my good and bad half.We all have times when we feel this way. But there are some people that do not know the difference between the two.The story Mary Reilly was Written by Valerie Martin.The other name for this dark tale is Dr.Jekyll and Mr.Hyde. By Robert Louis Stevenson. This is my mom's take on this tale of good vs evil, within ones self! mine is the two worked well together , in this dark thriller. John Malkovich , portrayed both characters equally well ! He really made me believe he had two totally different personalities. He was that convincing, I too loved this movie.
Dracula (1992)
Dracula beloved !
I have seen this rendition of the classic Bram Stoker's Gothic vampire novel. About the infamous Count Dracula Copola's vision really captured the dark essence of the story! I found it to be the best rendition ever, Gary Oldman's portrayal was incredible he really brought a chill down my spine. He was that terrifying, in this disturbing love triangle, of a beautiful young woman Mina (Winona Ryder), her handsome fiancé Jonathan (Keanu Reeves) and Dracula (Oldman)! The acting was fantastic by all, including Van Helsing( Hopkins ). This movie had it all, romance, death, vampires and other creatures of the night! And bloodshed ! The ultimate horror love story of all time! This is my daughter's take on this movie.Iam the one that told her,about this movie.I knew that she would love it as much,as I do.The love trio,between them is twisted yet some how hauntingly beautiful.
The Scarlet Letter (1995)
Beautiful sin
I love this movie , Demi Moore's portrayal of Hawthorne's character. From his classic novel was excellent, as the woman who had committed the carnal sin of adultery. And was considered a harlot and a witch. For not only did she have an affair , brought on by feelings of lust and desire. But it was with a Holy man sworn to be loyal and faithful to only the Lord our savior. Which was considered forbidden , so as her punishment she was forced to wear the scarlet letter 'A'. Which stood for adulteress, But she when found out she was with child. And out of wedlock she had only two options , neither one was promising. In the end she had only 4 options be hung, burned , end her affair with the Priest (Oldman) which was forced to leave the church. And her final choice leave with her child and never comeback! Great move fantastic acting ! Due to certain controversial content this movie isn't for everyone! But for anyone who appreciates classic literature this is the movie for you!
Hamlet (1990)
Prince on the brink of insanity
I love this movie, Mel Gibson's performance was Oscar worthy by far one of his best next to Braveheart! I haven't seen very many versions of the classic Shakespeare's play, but two. But this one surpassed the other one by far ! This is my daughters take on this movie.I have seen every one of the older versions of this play.And I can honestly say that his performance is just as good,as the men that portrayed this crazy prince in the past.Mel really made me believe that he was a mad man.He me feel sorry for him and mad at the next.If Shakespeare were alive to see him,in this play he would of loved it as much as I did. Glen Close, was great in this movie;she truly made me think that she too had gone mad.
The Libertine (2004)
Demented and repulsive!
This movie was the worst movie I have ever seen in my life time.Johnny Depp's performance was great. However the movie itself was down right awful.It was demented and degrading to gays and women. Toward the end of this piece of crap movie,he looked like a decaying corpse. I did not know that rotten flesh bad language and a lot of sex made a good movie.I thought that good acting and a good plot made a good movie.Not a man with a horrible affliction and bad acting. That is my mom's take on this ghastly movie, mine is I found it be appalling and an abomination! I did not know that obsession with man's genitals and orgies! Made a movie good! Depp's performance was one of his best ever, it is to bad. He wasted on such a disgusting , perverted piece of tripe! This movie is like the plague, it lingers and makes you suffer as you watch it! I think the worst part was his body deteriorate and wither in decay! We give this movie an F, not suitable for everyone due the pervese and disturbing content. How it made it to theaters we have no idea!
The Man in the Iron Mask (1998)
Fantastic classic
I love this movie , Leonardo Dicaprio's performances were stellar! This was a beautiful rendition , of the classic novel by Alexandre Dumas. Though I have seen it many times, it is still one of my favorites. The cast was incredible, and the acting was superb! Especially from the four acclaimed and seasoned actors, who portrayed the aging Musketeers. The only part about this movie, was the mistreatment of the good twin Philipe. Forced to hide his face, and having to live in solitude in a dark dank cell. I really felt sorry for him, because he didn't deserve that punishment! The King (also Dicaprio), was a vindictive spoiled brat especially when he didn't get his way! I didn't care for him to much, but behind the betrayal and deception. There was one character that added levity and that was Portos, I found him to be quite comical! This was one of the best versions of this classic , I have ever seen. I would give it an A++! This is my daughter's take on the movie.I too loved this movie it is just as good as,the one that;Richard Chamberlain was in.


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"If you establish a democracy, you must in due time reap the fruits of a democracy. You will in due season have great impatience of the public burdens, combined in due season with great increase of the public expenditure. You will in due season have wars entered into from passion and not from reason; and you will in due season submit to peace ignominiously sought and ignominiously obtained, which will diminish your authority and perhaps endanger your independence. You will in due season find your property is less valueable, and your freedom less complete." ~ Benjamin Disraeli
Planck Telescope Maps Light of the Big Bang Scattered Across the Universe
Submitted by Persona non grata on Mon, 2013-03-25 00:00
The view of the heavens in red and blue speckles confirms with astonishing accuracy the theories cosmologists draw on to explain the evolution of the universe from a fraction of a second after the big bang.
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Being a Mudder℠ is all about taking on the obstacles in your life and the enormous sense of accomplishment that you feel when you overcome them.
We've scoured through hundreds of submissions to the Extreme Obstacle Design Challenge looking for the most epic, sadistic, creative (and buildable) idea on the planet. Check out the top 3 designs from around the globe and make sure to tune in on Friday to find out who will be taking home the grand prize trip to TMHQ to bring their idea to life with the insane obstacle experts on the Tough Mudder product team.
Tough Mudder Volunteers. They're the friendly faces donning orange T's along the course, boasting smiling faces, serving up encouraging words, and reminding you that pain is temporary, but the glory of sporting your orange finisher headband will last a lifetime.
International Mud Day celebrates we're all about - MUD. And no one knows how to embrace a good run in it better than Fruit Shoot Mini Mudders.
These natural born adventurers are found around the globe and come out to participate in the muddiest 1-mile run, completing epic obstacles that encourage teamwork and camaraderie. In honor of Mini Mudders worldwide who love dirt, conquering fears, and facing challenges as much as we do, we're dedicating International Mud Day to them.
Want to Make it Through Electroshock Therapy? 12 Do's and Don'ts Straight from the Finish Line Emcee
Looking at photos of Matteo Hritzo, one quickly sees that he's bursting with energy — always moving and shakin'. When he's not, you'll find him soaking in the action packed glory of his favorite show, American Ninja Warrior.
You'd never expect the young, active kid in front of you to have type 1 diabetes. Over the last two years, Tom Hritzo has watched his son Matteo manage the chronic disease that requires insulin injections multiple times a day, every day. This interruption of life is something no person should have to manage, let alone a child.
We are thrilled to announce that Microsoft Band is the official training wearable of Tough Mudder this season. As part of this new partnership, Microsoft Band are working with Tough Mudder to build custom Guided Workouts that help you train and get to the starting line for your next Tough Mudder.
When you think of running a Tough Mudder, do the words "yea, right" come to mind? If so, you're far from alone. We're always shocked to discover just how many Tough Mudder finishers thought they wouldn't be able to finish a Tough Mudder before signing up. The takeaway here? We're all stronger and more capable of accomplishing lofty goals than we think. And to help prove that, we've gone ahead and crafted a list of the top five myths about completing a Tough Mudder.


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Steering problem
1995 Chrysler Cirrus 6 cyl Front Wheel Drive Automatic
I have a cirrus that the power steering pump belt went and took out the power steering pump pulley. Can you just replace the pulley? It seemed to be made of plastic. And was pressed on? What do I do?
Sunday, March 28th, 2010 AT 1:49 PM


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ARLINGTON, Texas — Ben Revere got the call on the field. The Philadelphia speedster wasn't as fortunate in the replay office more than a thousand miles away.
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King of the Hill 1997 | TV Show Watchlist
Season 1, Episode 10 Keeping Up With Our Jonses
First Aired: April 27, 1997
Hank and Peggy's love of cigarettes is rekindled after Hank catches Bobby smoking, but Luanne is determined to nip their habit in the butt. Voices include Brittany Murphy, Pamela Segall, Mike Judge, Kathy Najimy.
Guest Cast
Pamela Segall Pamela Segall Bobby Hill
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Finance chiefs at companies including Baxter International, Northern Trust and Alaska Air are turning to outside consultants as they grapple with increasingly complex challenges ranging from shareholder activism to merger integration.
The rule of thumb that Republicans are better for investors and big business needs more nuance now.
Sprint continued to add customers in the latest quarter, helped by its aggressive discounting, and revenue slid less than expected amid indications the wireless carrier's reboot is gaining ground.
Apple has tapped a highly-regarded senior executive who helped bring to market many of Apple's signature products to oversee its fledgling automobile project, according to people familiar with the matter.
Yahoo's $4.83 billion sale to Verizon puts an exclamation point on a tumultuous two-decade run that began with success as the web's organizer, and ended with a cycle of failed leaders and strategic blunders.
Verizon's planned acquisition of Yahoo deepens the nation's largest wireless carrier's investment in digital media but hands it a troubled company in need of restructuring.
Twitter's shares have jumped more than 30% since Microsoft's deal for LinkedIn; why the rally looks overdone.
In a rare public dustup between two of the biggest collaborators in the aerospace industry, a major supplier to Boeing Co. said the world's largest plane maker was behind on tens of millions dollars in payments due at the end of last month.
The recent boom in oil transportation by rail in the U.S. is in decline, threatening what was once viewed as a sizable driver of growth for the railroad industry.
Gilead's second consecutive revenue miss won't make deal speculation go away.


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Clink: Watermelon Sangria
We can't think of a better way to stay refreshed with the warm weather hanging around during the holiday season.
Those seeking a taste of something refreshingly different can stop by the DiLido Beach Club at The Ritz-Carlton South Beach for a carafe of watermelon sangria with friends (or a glass for you), which tastes as if you were biting into the juicy fruit with a dash of sweet lime flavors. Soak in the beachside views and enjoy.
Watermelon Sangria
Prepare a chilled carafe
Muddle a handful of watermelon cubes to the bottom
Add 12 ounces of Sparkling Rosé (Rosa Regale Banfi preferred)
Add 2 ounces of triple sec
Add 4 ounces of simple syrup
Add 4 ounces of Rose Water
Stir softly
Add a squeeze of lemon, lime and orange into drink
Garnish with 8 strawberries cut in quarters, handful of watermelon cubed and 8 grapes cut in half.
The Watermelon Sangria is around $9 a glass and $28 a carafe at DiLido Beach Club at the Ritz Carlton South Beach, 1 Lincoln Rd., Miami Beach; 305-793-8268.
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We have a mirrored SQL server setup with a pair of LTM's holding the mirror VIP. We're trying to setup a health monitor that runs a query against both servers in the mirror and directs traffic to the principal. Right now we have a query running that should only be possible on the active side of the mirror, but it's showing that both nodes are green. Any ideas?
F5 can't natively support queries directly against a database. As such, this may be why you are having an issue. You may want to look into external health monitors


text: home > allergies center > allergies a-z list > nasal airway surgery index Nasal Airway Surgery Nasal Airway SurgeryRelated Procedures & Tests « Back to Nasal Airway Surgery Index Sorted Alphabetically A-Z Sort by popularity CT Scan (Computerized Tomography) Electrocardiogram (ECG or EKG) Oximetry Questions To Ask Before Surgery Sinus Surgery (Patient Instructions) Sorted by Popularity (as on MedicineNet) Sort alphabetically Sinus Surgery (Patient Instructions) CT Scan (Computerized Tomography) Electrocardiogram (ECG or EKG) Questions To Ask Before Surgery Oximetry Suggested Reading on Deviated Septum Surgery (Septoplasty) and Turbinectomy by Our Doctors Related Diseases & Conditions 10 articles Sinus Infection (Sinusitis) Sinus infection (sinusitis) is caused by allergies, Nosebleed Nosebleed is common in dry climates during winter months, and in hot dry climates with low humidity. Individual taking blood clotting medications, aspirin, Chronic Rhinitis and Post-Nasal Drip Allergic rhinitis symptoms include an itchy, Cough (Chronic Cough) Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as Chronic Bronchitis Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least three months, two years in a row. Causes of chronic bronchitis Sinus Headache Sinus headache is caused by a sinus infection or Sleep Apnea Sleep apnea is defined as a reduction or cessation Black Eye The most common cause of a black eye is due to an injury to the face or head. Most black eye injuries are minor and heal on their own, however, some may Sleep (How to Get a Good Night's Sleep) A number of vital tasks carried out during sleep help maintain good health and enable people to function at their best. Deviated Septum A deviate septum is a condition in which the bone and cartilage that divide the nasal cavity of the nose in half (nasal septum) is significantly off center Medications 2 articles Procedures & Tests 5 articles Pictures, Images & Quizzes 2 articles Doctor's & Expert's Views 3 articles Health News 1 articles Health Features 0 articles Allergy and Asthma Newsletter Let MedicineNet deliver FREE to your inbox the latest updates and information on allergies and asthma. BONUS! Get a Free Health & Wellness PDF Guide when you sign up! *Privacy Policy From WebMD Allergies Resources Deadly Allergies: Why Every Second Counts Antihistamine or Decongestant? Habits That Can Make You Sick Featured Centers Feeling Short of Breath? What to Eat When You Have Cancer Top 3 Anaphylaxis Triggers Health Solutions From Our Sponsors Frequent Constipation? Greater Food Accessibility Exclusives What Does Psoriasis Look Like? How to Prevent Muscle Cramps Blood Clot? Know the Signs and Symptoms Allergy Triggers: Do You Know Yours?


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YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction
Version of Record online: 7 JUN 2007
DOI: 10.1111/j.1462-5822.2007.00990.x
Cellular Microbiology
Volume 9, Issue 11, pages 2700–2715, November 2007
Additional Information
How to Cite
Sweet, C. R., Conlon, J., Golenbock, D. T., Goguen, J. and Silverman, N. (2007), YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction. Cellular Microbiology, 9: 2700–2715. doi: 10.1111/j.1462-5822.2007.00990.x
Publication History
- Issue online: 27 JUL 2007
- Version of Record online: 7 JUN 2007
- Received 23 April, 2007; revised 22 May, 2007; accepted 23 May, 2007.
- Abstract
- Article
- References
- Cited By
The Yersinia pestis virulence factor YopJ is a potent inhibitor of the NF-κB and MAPK signalling pathways, however, its molecular mechanism and relevance to pathogenesis are the subject of much debate. In this report, we characterize the effects of this type III effector protein on bone fide signalling events downstream of Toll-like receptors (TLRs), critical sensors in innate immunity. YopJ inhibited TLR-mediated NF-κB and MAP kinase activation, as suggested by previous studies. In addition, induction of the TLR-mediated interferon response was blocked by YopJ, indicating that YopJ also inhibits IRF3 signalling. Examination of the NF-κB signalling pathway in detail suggested that YopJ acts at the level of TAK1 (MAP3K7) activation. Further studies revealed a YopJ-dependent decrease in the ubiquitination of TRAF3 and TRAF6. These data support the hypothesis that YopJ is a deubiquitinating protease that acts on TRAF proteins to prevent or remove the K63-polymerized ubiquitin conjugates required for signal transduction. Our data do not directly address the alternative hypothesis that YopJ is an acetyltransferase that acts on the activation loop of IKK and MKK proteins, but support the conclusion that the critical function of YopJ is to deubiquinate TRAF proteins.


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Events Calendar
Trendsetter Tour: Bryce Vine Concert!
Thursday, September 04, 2014
Bryce Vine will perform at 8:30 p.m. Thursday, Sept. 4 in the Explorer Rooms of the University Center.
This concert is free with an NMU ID and $2 for the general public.
Bryce's sound is a blend of singable radio friendly pop and laid back, in-the-cut hip-hop. He's been described as an innovative urban artist with pop melodies to keep you dancing. Learn more about him at http://brycevinemusic.com/ and like his Facebook page at https://www.facebook.com/brycevine
This concert is sponsored by Northern Arts and Entertainment.
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Event ContactJordan Paquet
CostFree with NMU ID and $2 for the general public
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Cher coming to BMO Harris Bradley Center June 6
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She must need to pay for some more hideous plastic surgery.Hide replies
"YOU GOTTA BE KIDDING", you seem like such a sweet person.....
Cher was on the Today Show this morning singing one of her old hits. While I admire her success, she didn't sound very good today. Some people don't seem to know when to hang it up.
YGBK Mean or cliche... pick one or the other, not both.
Hey, if she comes wearing a thong and high boots, she can have all the plastic surgery she wants.
nice 1 Mark but I hope those fishnets don't reveal too much cheekiness?
Mark L only likes it if guys show up wearing a thong and high boots....
if I go, I'm going to throw my boxer-briefs @ her!
She has had a remarkable career. It's unfortunate that her "style" of music does not wear well for an older woman. It's interesting how men can continue on long after they can no longer sing a note( Dylan, Lenard C.) but it never works for women.Hide replies
I think her performances disprove what you are saying. She certainly sounds a lot better than Paul McCartney, who we all revere but whose voice is cringe-inducing. Cher's always had a sense of self-parody about her that makes her endearing and enduring.
Without voice enhancements she would be a perfect duet partner for anyone else who can't sing.
She's still living? Is Cher the person who used to be a man named Sonny and then she had gender reassignment surgery?
At least her face, after 10 years of healing is starting to look a little more natural, when they lace up the face sometimes they can pull the strings just a might too tight.
I'd rather sit and listen to William Shatner recite the 4000 pages of the ACA.
Really, could there be anything more boring than Cher?
The mayor will be there in the front row wearing his sheer black body suit.
First time in Milwaukee since 2003. That's probably not an accident.
She really struggled on the Today Show on Monday.
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When new CEO comes in to clean house he or sheinsists on having carte blanche to do what is necessaryin terms of cleaning house. Almost always meanswritedowns/writeoffs to put the mess behind the new CEO. As a CPA Ihave seen this 100X before. Do I know of any as oftoday. Absolutely not. The surprises just start coming.Happened at FTU, MEL many years ago, JPM, UPC, BAC, WFB,and on and on. If you are an employee you will haveto wait and see what happens next. I'm just takingout the CEO transition handbook and reading from it! For those of you that thought the Pru Bache"hold" was enthusiastic better check again. Havingridden FTU all the way down and now back up I do notwish ONE shareholders the same trip; I'm just afraidthat so many things are going to start coming out thatwere never even on the radar. For the record I nevershort stocks so I will wait for ONE to come back to the20s.


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Everlasting Victory
Orlando, FL
Saturday, June 8th, 2013 at 6:00pm
All Ages
This 8th of June, come to the Fashion Square Mall to see E/V perform Dance on Cloud 9 and support and cheer as E/V will make it to the tour finale. And see E/V rip the runway for Audition America.
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|This Just In
|shoes & accessories
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Product Details
We'd like one of everything from Austin shop JM Drygoods—owner Michelle Teague (who named the store after her son, Jack Maverick) stocks richly crafted clothing and accessories handmade by Mexican artisans. This incredibly versatile sash belt is a particular standout.
JM Drygoods™ Thick Sash Belt
Rated 4 out of 5Â by 1 reviewer.
Rated 4 out of 5Â by Mona a bit too long This belt is beautiful, my only problem with it is that it is a bit too long. I have to tie it as tight as it can possibly go to get it sit around my hips and even then it is pretty loose. I am keeping it because its beautiful, but would probably work better for someone with more hips than me. May 21, 2014
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A pointless super power is a supernatural ability that has no practical value. The humor is in the fact that you would be better of without that special ability. Enjoy this funny collection of pointless superpowers and write you own!
"Man: HELP! HELP! MY PENIS IS GONE! SOMEONE HELP ME FIND IT! Woman: OMG I am a nurse, we must find it before its too...."
via: Anti-Pickup Line
"What's worse then stubbing your toe? Finding out one of your loved ones died.."
via: Clarksonisms
via: Pointless Inventions
"I sometimes wonder if im the only living person on earth and everyone else is just there in order to affect my existance -Henry."
©2008-2014 Pointless Super Powers. All rights reserved.
A Horse Head Huffer Production.
Rails Hosting provided by BlueBox


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The North Quincy Red Raiders football team has a home non-conference game vs. Milton on Tuesday, August 30 @ 4p.
MaxPreps is looking for one person to be the Official Scorer! This person will provide LIVE play-by-play for fans to follow along during the game.
If you have any corrections for the North Quincy football schedule please contact Support.


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Andrea Girardi
For the glory, for the money and for the fun. Mostly for the money!
Always code as if the guy who ends up maintaining your code will be a violent psychopath who knows where you live.
IT errors are like snowflakes
They didn't drop the ball. They dropped the ball, kicked the coach in the nuts and took a crap in the quarterback's mouth
If they see a scrambled mass of code that looks like it was written by a bevy of drunken sailors, then they are likely to conclude that the same inattention to detail pervades every other aspect of the project
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Hope everyone had a good weekend!!!
Ok, so pregnant or not pregnant, What is your favorite cold sandwich? Your favorite hot sandw
Hope everyone had a good weekend!!!
Ok, so pregnant or not pregnant, What is your favorite cold sandwich? Your favorite hot sandw
My favorite cold sandwich is avocado, turkey, and cheese. Togo's makes a really good one.
My favorite hot sandwich is a grilled turkey and havarti sandwich. Yum.
Jimmy Johns- beach club (turkey, cheese, avocado, and other yummy veggies) minus the mayo.
hot.. not sure? How about a burger from Red Robin? Mmmm.
Dang it, Lenora, you are making me hungry! lol
I like Turkey spread and PB&J.
Hot I like grilled cheese.
Oh and I like tuna salad.
Hot sandwich has to be a Rueben!
Cold sammie....turkey and provolone
Hot- anything italian - love ham, salami, provolone, proscuitto, italian dressing or vinegar.
Cold- roast beef w/ provolone, same as above, but cold, chicken or tuna salad, turkey w/ provolone
Dang it, now I really want a yummy sandwich!
Cold- Turkey BLT from Frank and Nic's in Baltimore MD
HOT- Turkey Rueben.
Cold - BLT on a bagel with cheddar cheese...yum!
Hot - Gotta be a reuben, extra saurkraut
Lenora, you always come up with the funniest questions!
I totally want a sandwich now too. I'm such a big foodie, so most of my questions tend to revolve around food, in case you haven't noticed. I think something like 80% of my Facebook statuses are food-related, lol.
Cold: honey turkey and Swiss on a roll w mayo.
Hot: I guess a good old fashioned cheeseburger?
I'm not a huge sandwich fan, so I guess I like either the Bacon, chicken ranch or seafood sandwich from subway....and hot I get the Caesar chicken wrap w ranch from my friends bar and grill
Cold- a true, NY deli american hero- ham, turkey, roast beef, american cheese, lettuce, tomato on a hero roll.
Hot- meatball sub
I'm really not a big sandwich person but when I have a cold sandwich is almost always a turkey sandwich, cheese just depends on what we have, I prefer provolone. Hot, definitely a grilled chicken sandwich with chipotle cheddar cheese
My favorite cold sandwhich is a Turkey, Bacon & Avocado, with extra Bacon of course!
My favorite hot has got to be a Reuben sandwhich. It's hard to find a good one around my area but when I do I've been known to have it a few days in a row :eek:
my favourite hot is grilled cheese!!! mmmmm
cold my fav would be chicken and bacon!! yumm now im hungry lol!! all i have to do is think about food and im hungry these days
cold sandwich: Mortadella with mayo and lettuce (from this awesome italian deli in Greensboro)
hot??? Hmmm, Pastrami and mustard.....from Togo's in CA...sigh I miss Togo's.