text:
|Publication number
|Publication type
|Application number
|Publication date
|Nov 17, 1998
|Filing date
|Jun 7, 1995
|Priority date
|Jun 7, 1995
|Fee status
|Also published as
|Publication number
|Lars Orning, Beate Arbo, Peter Fischer, Kjell S. Sakariassen
|Original Assignee
|Nycomed Imaging As
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (1), Non-Patent Citations (7), Referenced by (3), Classifications (10), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
1. Field of the Invention
The present invention is concerned with peptide reagents and compositions thereof which reduce blood clotting initiated by the ternary complex of tissue factor (TF), FVIIa and FXa. Reducing the formation of FX coagulant activity (FXa) by interfering with the formation of the ternary complex TF/FVIIa/FXa inhibits TF-dependent blood clotting. Thus the extrinsic pathway of coagulation is inhibited.
2. Background Art
Blood clotting relies upon a cascade of enzymatic reactions which eventually results in the formation of a fibrin clot (Furie B. & Furie B. C.: Molecular and cellular biology of blood coagulation. N. Eng. J. Med. 326, 800, 1992). The triggering mechanism is either initiated by contact with an artificial surface (intrinsic coagulation pathway) or by TF at a vessel wall lesion (extrinsic coagulation pathway). The process of blood coagulation is a defense mechanism which prevents blood loss following vessel wall injury (hemostasis). However, a similar process may also be triggered at a vascular lesion where blood loss is not a threat, but which unfortunately may result in thrombus formation (thrombogenesis). It is thought that the extrinsic pathway of coagulation is the dominating one in vivo, both in hemostasis and thrombosis (Gailani D. & Broze G. J.: Factor IX activation in a revised model of blood coagulation. Science 253, 909, 1991, and Nemerson Y.: The tissue factor pathway of coagulation. Hemostasis and Thrombosis: Basic Principles and Clinical Practice, Third Edition. Eds. R. W. Colman, J. Hirsh, V. J. Marder & R. W. Salzman. J. B. Lippincott Company, Philadelphia, p81, 1994).
FX is activated by the catalytic activity of the binary TF/FVIIa complex in the presence of CA2+ on phospholipid-rich surfaces (Nemerson Y.: Tissue Factor and Hemostasis. Blood 71, 1, 1988). During this event, FX complexes with the preformed TF/FVIIa complex and is subsequently activated and released. Thus, a ternary complex is formed which has FX coagulant activity (FXa). Activation of this extrinsic pathway of coagulation leads to fibrin formation which apparently is of prime importance in development of arterlosclerotic lesions and in reocclusion and restenosis following endarterectomy (Weiss II. J., Turitto V. T., Baumgartner H. R., Nemerson Y. & Hottmann T.: Evidence for the presence of tissue factor activity on subendothelium. Blood 73, 968, 1989; Hultin M. S.: Fibrinogen and factor VII as risk factors in vascular disease. Progress in Hemostasis and Thrombosis. Volume 10, Ed. B. S. Coller, W. B. Saunders, Philadelphia, p215, 1991; and Jang I. K., Gold H. K., Leinback R. C., Fallon J. T., Collen D. & Wilcox J. N.: Antithrombotic effect of a monoclonal antibody against tissue factor in a rabbit model of platelet-mediated arterial thrombosis. Arterioscler. Tromb. 12, 948, 1992). Relatively little is known about the molecular interactions between TF and FVIIa and between TF/FVIIa and FX.
Mouse TF, in contrast to rabbit TF, does not support the procoagulant activity of human FVIIa on FX (Andrews B. S., Rehemtulla A., Fowler B. J., Edgington T. S. & Mackman N.: Conservation of tissue factor sequence among three mammalian species. Gene 98, 265, 1991). Whether this effect is due to lack of compatibility between mouse TF and human FVII and/or FX is not known. Recently, three putative binding sites for FVIIa and one for FX were identified in human TF (Harlos K., Martin D. M. A., O'Brien, Jones E. Y., Stuart D. I., Polikarpov I., Miller A., Tuddenham E. G. O. & Boys C. W. G.: Crystal Structure of the extracellular region of human tissue factor. Nature 370, 662, 1994). When studying the species homology for these binding regions, we found striking homology for the putative FVIIa binding sites (>80% for 10 residues comprising putative FVIa binding sites). However, for the FX recognition site there is low homology between man and mouse (40% for 10 residues, residues are identified below), whereas the homology between man and rabbit is higher (70% for 10 residues, residues are identified below). It therefore seemed likely that the incompatability between man and mouse TF and human FVIIa and/or FX is localized to this region, resulting in impaired FX binding and FX activation. The putative FX binding site on the TF molecule is outlines below:
FX Putative Binding Site
Rabbit: (SEQ. ID. NO: 3) 152--Thr--Leu--Tyr--Tyr--Trp--Arg--Ala--Ser--Ser--Thr--161 (70%)
Man: (SEQ. ID. NO: 1) 154--Thr--Leu--Tyr--Tyr--Trp--Lys--Ser--Ser--Ser--Ser--163
Mouse: (SEQ. ID. NO: 2) 158--Ile--Ile--Thr--Tyr--Arg--Lys--Gly--Ser--Ser--Thr--167 (40%)
Site-directed mutagenesis of TF as well as synthetic peptides has in addition indicated a domain of the TF molecule which appears important for the activation of FX by the binary TF/FVIIa complex (Edgington T. S. & Morrissey J. H., U.S. Pat. No. 5,110,730, May 5, 1992). This domain is located at residues 152-169 of the mature TF molecule.
We have surprisingly found that peptides of smaller side (10-mers), and not based on the primary sequence of human TF, are very potent inhibitors or TF-dependent coagulation in humans.
The invention thus provides peptides having the amino acid sequences Ihr--Leu--Tyr--Tyr--Trp--Arg--Ala--Ser--Ser--Thr and Ile--Ile--Thr--Tyr--Arg--Lys--Gly--Ser--Ser--Thr, all (SEQ. ID. NO: 2) amino acids other than glycine being in the conventional L form.
The invention also provides the abovementioned peptides for use in the treatment or prevention of blood clotting disorders or problems in a human subject.
FIG. 1 is a graph which shows activity of the peptides (SEQ. ID. NO: 1), (SEQ. ID. NO: 2), and (SEQ. ID. NO: 3) on the vertical axis versus the concentration of the peptides on the horizontal axis.
FIGS. 2a and 2b are Dixon Plot graphs which illustrate the inhibitory mechanism of FXa formation obtainable by this invention. The inverse of the rate of FXa is on the vertical axis and the peptide concentration is on the horizontal axis.
The peptides of the invention differ from those of previous publications in this particular area and from the above cited patent, since they are not based on the primary sequence of human TF. In contrast, they have primary sequences identical to murine and rabbit TF, showing 40% and 70% homology respectively with human TF. Furthermore, kinetic analysis reveals that both peptides inhibit extrinsic coagulation by competing with the binary complex of TF/FVIIa for FX. This implies that the conversion of FX to FXa by the TF/FVIIa complex is inhibited. Thus, the peptides have unique amino acid sequences, inhibitory capacity in a relevant bioassay and a well established mechanism of inhibition. Such inhibitors represent a novel approach for inhibition of coagulation and thrombus formation in humans. As such, these peptide and compositions thereof may be used as human antithrombotics, both in prophylaxis and treatment.
The activity of the peptide Ile--Ile--Thr--Thr--Arg--Lys--Gly--Ser--Ser--Thr (SEQ. ID. NO: 2) is particularly surprising given that native mouse TF does not support the human procoagulant activity of human FVIIa on FX (see the reference cited above).
The inhibitory capacity of the peptides was measured by a so-called lipidated TF assay which is a chromogenic assay measuring the FXa generated by the binary complex of TF/FVIIa. FVIIa (5 pM final concentration) and FX (20 nM) were combined in the presence of different concentrations of peptide and incubated for 15 min at ambient temperature. TF (5 pM) and CaCl2 (5 mM) were added to initiate the reaction. Reactions were quenched with EDTA and the FXa activity was measured in an amidolytic assay, using the chromogenic FXa substrate S2765 (trade name). Data from these studies with this assay are shown in FIG. 1, and Table 1 hereinafter gives the corresponding IC values. Data are plotted as the percentage of the rate of FXa formation determined without peptide versus the concentration of the following peptides: hu#154-163 (SEQ. ID. NO. 1) (), mu#158-167 (SEQ. ID. NO. 2) (x) and rb#152-161 (SEQ. ID. NO. 3) (Δ). It is noted that the IC values for mu#158-167 (SEQ. ID. NO. 2) and rb#152-161 (SEQ. ID. NO. 3) are in the very low μm range.
TABLE 1______________________________________Inhibition of FXa formation by synthetic TFpeptide analogs. IC50Peptide aa sequence (μM)a______________________________________hu#154-163 (SEQ ID NO:1) Thr--Leu--Tyr--Tyr--Trp 100b Lys--Ser--Ser--Ser--Sermu#158-167 (SEQ ID NO:2) Ile--Ile--Thr--Tyr--Arg-- 21 Lys--Gly--Ser--Ser--Thrrb#152-161 (SEQ ID NO:3) Thr--Leu--Tyr--Tyr--Trp-- 14 Arg--Ala--Ser--Ser Thr______________________________________ a The concentration of peptide inhibiting the rate of FX activation by 50%. b The IC50 value may be underestimated because of difficulties in dissolving the peptide.
The inhibitory mechanism of FXa formation was elucidated by analysis of Dixon plots as shown in FIGS. 2A and 2B. Different concentrations of peptide were mixed with FVIIa and three different concentrations of FX and, after addition of TF, the rate of FXa formation was determined. In another experiment, different concentrations of peptide were mixed with FVIIa and three different concentrations of TF, in excess of FVIIa. After addition of FX, the rate of FXa formation was determined. Results were plotted according to Dixon, the inverse of the rate of FXa formation versus peptide concentration. Peptide mu#158-167 (SEQ. ID. No. 2), produced linear regression lines, which intercepted on the abscissa (different FX concentrations) or above the abscissa (different TF concentrations). These results are consistent with a mechanism where the peptide mu#158-167 (SEQ. ID. NO. 2) competes with TF or FVIIa/TF complex for interaction with FX.
Thus, it is possible that the mouse and rabbit peptides have conformations mimicking the FX binding site of the binary human TF/FVIIa complex in spite of the low sequence homologies.
The present invention also provides pharmaceutical compositions containing one or more of the peptides of the invention of salts thereof.
Salts of the peptides include physiologically acceptable acid addition salts such as the hydrochloride.
The compositions according to the invention may be presented, for example, in a form suitable for nasal or parenteral administration.
Thus the compounds according to the invention may be presented in the conventional pharmacological forms of administration, such as nasal sprays, solutions and emulsions. Conventional pharmaceutical excipients as well as the usual methods of production may be employed for the preparation of these forms. Organ specific carrier systems may also be used.
Injection solutions may, for example, be produced in the conventional manner, such as by the addition of preservation agents, such as p-hydroxybenzoates, or stabilizers, such as EDTA. The solutions are then filled into injection vials or ampoules.
Nasal sprays may be formulated similarly in aqueous solution and packed into spray containers either with an aerosol propellant or provided with means for manual compression. Capsules containing one or several active ingredients may be produced, for example, by mixing the active ingredients with inert carriers, such as lactose or sorbitol, and filling the mixture into gelatin capsules.
Dosage units containing the compounds of this invention preferably contain 0.1-10 mg, for example 1-5 mg of the peptide or salt thereof.
As indicated above, one aspect of the invention provides peptides according to the invention for use in the treatment or prevention of blood clotting disorders or problems in a human subject. Blood clotting disorders include thrombosis (particularly vascular thrombosis or deep vein thrombosis), acute myocardial infarction, restenosis, reclosure, angina, cerebrovascular disease, peripheral arterial occlusive disease, hypercoagulability and pulmonary embolism. The peptides according to the invention can also be used to prevent occurrence of blood clotting problems caused by, for example, injury to blood vessels during thrombolytic therapy, grafting surgery, vessel patency restoration etc. Blood clotting disorders may be triggered by sepsis due to production of TNF-α or IL-1.
In a still further aspect, the present invention also provides a method of treatment of blood clotting disorders in the human body, said method comprising administering to said body one or more peptides according to the invention or salts thereof. Prophylactic methods of treatment are also provided, whereby a peptide according to the invention is administered to a patient to prevent or reduce the occurrence of possible blood clotting problems, for example during surgery or other invasive techniques. The peptide will of course normally be administered in the form of a pharmaceutically acceptable composition.
In another aspect, the present invention provides a process for the preparation of the peptides according to the invention.
The peptides of the present invention can be prepared by methods known in the art. Typically, the desired sequences are assembled by solid-phase peptide synthesis. Standard procedures for the synthesis strategy employed for the examples of this invention are described in E. Atherton & R. C. Sheppard, Solid phase peptide synthesis: a practical approach, 1989, IRL Press, Oxford. For example, a synthesis resin with an acid-labile linker group, to which the desired protected C-terminal amino acid residue has been esterified, is used. In the following example, so-called TentaGel resins with a trityl-derived linker were applied (Bayer, E., Clausen, N., Goldammer, C., Henkel, B., Rapp, W. & Zhang, L. (1994) in Peptides: Chemistry, Structure and Biology (Hodges, R. S. & Smith, J. A., eds.), pp. 156-158, ESCOM Leiden). The amino-protecting group is then removed and the second amino acid in the sequence is coupled using a suitable condensation reagent. Amino acids with semi-permanent amino protecting groups and permanent protecting groups for the functional side chains are employed. Amino-deprotection and coupling cycles are then repeated in alternating steps until the sequence of interest is assembled. Finally the permanent side-chain protecting groups are removed and the peptide is cleaved from the synthesis resin, usually simultaneously through treatment with a suitable acidic reagent.
Alternatively, the peptides can by synthesised through solution peptide synthesis methods known in the art, either in a step-wise manner from the carboxyl terminus and/or through the application of segment condensation or ligation methods, employing comprehensive or minimal protection strategies. Combined solution-solid phase segment condensation approaches can also be applied.
Generally, the reactive groups present (for example amino, hydroxyl, thiol and carboxyl groups) will be protected during overall synthesis as indicated above. The final step in the synthesis will thus be the deprotection of a protected derivative of the peptides of the invention. A wide choice of protecting groups for amino acids is known (see, e.g., Greene, T. W. & Wuts, P. G. M. (1991) Protective groups in organic synthesis, John Wiley & Sons, New York). Thus for example amino protecting groups which may be employed include 9-fluoroenylmethoxycarbonyl (Fmoc), benzyloxycarbonyl, t-butyloxycarbonyl, etc. It will be appreciated that when the peptide is build up from the C terminal end, an amino-protecting group will be present on the α-amino group of each new residue added and will need to be removed selectively prior to the next coupling step. One particularly useful group for such temporary amine protection is the Fmoc group which can be removed selectively by treatment with piperidine in an organic solvent. Carboxyl protecting groups which may for example be employed include readily cleaved ester groups such as t-butyl and benzyl, as well as esters with solid phase-bound linkers, e.g. p-alkoxybenzyl, trityl, etc. It will be appreciated that a wide range of other such groups are known in the art. The use of all such protecting groups and the processes described above falls within the scope of the present invention.
The invention is illustrated by the following Examples.
H--Thr--Leu--Tyr--Tyr--Trp--Lys--Ser--Ser--Ser--Ser--OH (huTF residues 154-163) (SEQ. ID. NO: 1)
The peptidyl resin corresponding to the above sequence was assembled on Fmoc--Ser(But)-- TentaGel S Trt resin! (0.2 mmol/g; from Rapp Polymere GmbH, Tubingen, Germany) using an Applied Biosystems model 433A peptide synthesizer. Fmoc deprotection was achieved with conductivity monitoring using 20% piperidine in N-methylpyrrolidone (NMP). The washing solvent was NMP. The residues (from the carboxyl terminus) were assembled using double couplings with 10-fold molar excess of Pmoc-amino acids and 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium-hexafluorophosphate (HBTU)/1-hydroxybenzotriazole (HOBt)/Pri 2 NEt in NMP using 75 min coupling cycles. Prior to Fmoc-deprotection at each sequence position capping was carried out using a solution of acetic anhydride (4.7% v/v)/Pri 2 NEt (2.2% v/v)/HOBt (0.2% w/v) in N,N-dimethylformamide. The amino acid-side chain protecting groups used were t-butoxycarbonyl for Lys and t-butyl for Ser, Thr and Tyr. The final Fmoc-deprotected and washed (dichloromethane) peptidyl resin was dried in vacuo. An aliquot (300 mg) was treated with a mixture containing phenol, 1,2-ethanedithiol, thioanisole, water and CF3 COOH 0.75:0.25:0.5:0.5:10, w/v/v/v/v) for 3 h. The resin residue was then filtered off and washed with small quantities of neat CF3 COOH. The combined filtrate and washings were triturated with Et2 O to obtain the crude peptide. The precipitate was collected by filtration, washed with Et2 O and then taken up in 0.1% aq CF3 COOH and lyophilised. An aliquot (25 mg) of the crude product was redissolved in 0.1% aq CF3 COOH (3 mL), filtered and purified by preparative RP-HPLC. The column (Vydac 218TP1022, 2.2�25 cm) was eluted at 10 ml/min with a gradient of 0 to 20% MeCN in 0.1% aq CF3 COOH over 90 min. Appropriate peak fractions were pooled and lyophilised to afford 12 mg of pure peptide. Analytical RP HPLC: tR -19.6 min, purity 99% (Vydac 218TP54, 0.46�25 cm, 0-30% MeCN in 0.1% aq CF3 COOH over 20 min at 1 ml/min, λ=215 nm). FAB MS: M+II!+ =1221.6 m/z, C57 H81 N12 O18 =1221.3. Amino acid analysis: Leu 1.01(1), Lys 1.05(1), Ser 3.96(4), Thr 1.00(1), Tyr 1.98(2), Trp was not determined.
H--Ile--Ile--Thr--Tyr--Arg--Lys--Gly--Ser--Ser--Thr--OH (muTF residues 158-167) (SEQ. ID. NO: 2)
The peptidyl resin corresponding to the above sequence was assembled on Fmoc-Thr(But)- TentaGel R Trt resin! (0.17 mmol/g; from Rapp Polymere GmbH, Tubingen, Germany) in a similar fashion to the corresponding peptidyl resin in Example 1. The side chain protecting group used for Arg was 2,2,5,7,8-pentamethylchroman-6-sulphonyl. The completed peptidyl resin was worked up and an aliquot (500 mg) treated with the same acidolysis reagent as in Example 1. After precipitation from Et2 O, the product was dissolved in glacial AcOH and lyophilised. The crude product (99 mg) was redissolved in 10% aq MeCN containing 0.1% CF3 COOH (6 mL), filtered and purified in two batches by preparative RP-HPLC using the same conditions as described in Example 1. Appropriate peak fractions were pooled and lyophilised to afford 74 mg of pure peptide. Analytical RP-HPLC: tR =14.7 min, purity 98% (Vydac 218TP54, 0.46�25 cm, 0-30% MeCN in 0.1% aq CF3 COOH over 20 min at 1 ml/min, λ=215 nm). FAB-MS M+H!+ =1125.5 m/z, C49 H84 N14 O16 1125.3. Amino acid analysis: Arg 1.02(1), Gly 1.02(1), Ile 1.22(2), Lys 1.00(1), Ser 2.01(2), Thr1.95(2), Tyr 1.01(1).
H--Thr--Leu--Tyr--Tyr--Trp--Arg--Ala--Ser--Ser--Thr--OH (rbTF residues 152 161) (SEQ. ID. NO: 3)
The peptidyl resin corresponding to the above sequence was assembled on Fmoc--Thr(But)- TentaGel R Trt resin! (0.17 mmol/g; from Rapp Polymere GmbH, Tubinge, Germany) in a similar fashion to the corresponding peptidyl resin of Example 1. The side chain protecting group used for Arg was 2,2,5,7,8-pentamethylchroman-6-sulphonyl. The completed peptidyl resin was worked up and an aliquot (520 mg dry weight) treated with the same acidolysis reagent as in Example 1. After precipitation from Et2 O, the product was dissolved in glacial AcOH and lyophilised. An aliquot of the crude product (40 mg) was redissolved in 10% aq MeCN containing 0.1% CF3 COOH (4 mL), filtered and purified by preparative RP-HPLC using the same conditions as described in Example 1. Appropriate peak fractions were pooled and lyophilised to afford 25 mg of pure peptide. Analytical RP-HPLC: tR =20.6 min, purity 97% (Vydac 218TP54, 0.46�25 cm, 0-30% MeCN in 0.1% aq CF3 COOH over 20 min at 1 ml/min, λ=215 nm). FAB MS: M+H!+ =1247.7 m/z, C49 H54 N14 O16 -1247.4. Amino acid analysis: Ala 1.01(1), Arg 1.02(1), Leu 1.00(1), Ser 1.99(2), Thr 1.97(2), Tyr 2.00(2), Trp was not determined.
__________________________________________________________________________SEQUENCE LISTING(1) GENERAL INFORMATION:(iii) NUMBER OF SEQUENCES: 3(2) INFORMATION FOR SEQ ID NO: 1:(i) SEQUENCE CHARACTERISTICS:(A) LENGTH: 10 amino acids(B) TYPE: amino acid(D) TOPOLOGY: linear(ii) MOLECULE TYPE: peptide(iii) HYPOTHETICAL: NO(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1:ThrLeuTyrTyrTrpLysSerSerSerSer1510(2) INFORMATION FOR SEQ ID NO: 2:(i) SEQUENCE CHARACTERISTICS:(A) LENGTH: 10 amino acids(B) TYPE: amino acid(D) TOPOLOGY: linear(ii) MOLECULE TYPE: peptide(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2:IleIleThrTyrArgLysGlySerSerThr1510(2) INFORMATION FOR SEQ ID NO: 3:(i) SEQUENCE CHARACTERISTICS:(A) LENGTH: 10 amino acids(B) TYPE: amino acid(D) TOPOLOGY: linear(ii) MOLECULE TYPE: peptide(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3:ThrLeuTyrTyrTrpArgAlaSerSerThr1510__________________________________________________________________________
|Cited Patent
|Filing date
|Publication date
|Jun 25, 1987
|May 5, 1992
|The Scripps Research Institute
|Human tissue factor related DNA segments
|Furie B. and Furie, B.C. The New England Journal of Medicine, vol. 326, 800, 1992.
|Gailani and Broze et al, Science 253, pp. 909 912.
|Gailani and Broze et al, Science 253, pp. 909-912.
|Weiss et al, vol. 73, No. 4, Blood, 1989, pp. 968 975.
|Weiss et al, vol. 73, No. 4, Blood, 1989, pp. 968-975.
|Y. Nemerson, Blood, vol. 71, No. 1, 1988, pp. 1 8.
|Y. Nemerson, Blood, vol. 71, No. 1, 1988, pp. 1-8.
|Citing Patent
|Filing date
|Publication date
|Aug 12, 1998
|Jul 10, 2001
|Novartis Ag
|Calcium-regulated kinase
|May 19, 2003
|Nov 11, 2008
|Cyclacel Limited
|p21 peptides
|May 19, 2003
|Sep 9, 2004
|Cyclacel Limited
|p21 peptides
|U.S. Classification
|514/13.7, 530/328, 530/384
|International Classification
|Cooperative Classification
|European Classification
|Sep 5, 1995
Owner name: NYCOMED PHARMA AS, NORWAY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ORNING, LARS;ARBO, BENTE;FISCHER, PETER;AND OTHERS;REEL/FRAME:007614/0821;SIGNING DATES FROM 19950714 TO 19950731
|Jun 20, 1996
Owner name: NYCOMED IMAGING AS, NORWAY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:NYCOMED PHARMA AS;REEL/FRAME:007998/0700
Effective date: 19960606
|Jun 4, 2002
|Maintenance fee reminder mailed
|Nov 18, 2002
|Lapse for failure to pay maintenance fees
|Jan 14, 2003
|Expired due to failure to pay maintenance fee
Effective date: 20021117


text:
In Russia in the 1980's were very popular cigarette Rodopi.
I did not know that this beautiful mountain in Bulgaria.
Вот какие воспоминания :)) Тоже вспомнила :))А гора правда красивая!
Sign up to comment.
Sign in if you already did it.
Photo taken in Smolyan, Bulgaria
Misplaced? Suggest new location

subset: commoncrawl


text: 4. Atrion ( ATRI) sells health care supplies. The numbers: Third-quarter profit rose 12% to $4.5 million, or $2.20 a share, as revenue climbed 7% to $25 million. Atrion's gross margin inched up from 51% to 52%, and its operating margin climbed from 25% to 26%. The company has an ideal financial position, with $19 million of cash and no debt. The stock: Atrion soared 69% during the past year, beating major U.S. indices. The stock trades at a price-to-earnings ratio of 19, a discount to health care suppliers. The shares offer a 0.9% dividend yield. Prev 1 of 5 Next


text:
Change Your Image
Upload An Image
Crop And Save
IMDb member since April 2005
Latest Message Board Posts
Jan 28 2008
Jun 19 2006
Mar 20 2006
Sep 24 2005
Jun 11 2005
Midnight Cowboy (1969)
Friendship at its best
6 April 2006 - 1 out of 1 users found this review helpful.
Jon Voight and Dustin Hoffman play their hearts out as individuals who became outcasts and find an everlasting friendship in the slums of New York. This movie deserved the Oscar for Best Picture in 1969. It is the first and only "X" rated movie to get the prize. This movie has changed the way we feel about friendship and the many twists and turns that can occur in a friendship. Voight's performance as the naive Joe Buck makes you believe he can go anywhere. But Hoffman's performance as Ratzo Rizzo is one for the ages. Hoffman transforms into a character that is entirely believable. He makes you feel pity for him. The ending will show you that everybody has a dream. It just might not be in your reach. A+
See more▼See less▲


text:
Play Video
How to screw up a Fox News live broadcast
Posted by MaSSaCrE42O on Jul. 10, 2007
Elizabeth Rage takes you through the steps to create the Enchantress look f...
On this episode, Master Chalk Artist Chris Carlson takes on an epic Star Tr...
Get you geek on and come check out these hilarious clips!
Posted by MaSSaCrE42O on Jul. 10, 2007


text:
Seventh Circuit Contract Cases
Contract Product Liability Cases, Dockets and Filings
Cases filed
Cases 1 - 10 of 222
Protein 2o Inc v. Langlade Springs LLC
as 1:2016cv00975
Plaintiff: Protein 2o Inc
Defendant: Langlade Springs LLC
Cause Of Action: Diversity-Breach of Contract
Auto-Owners Insurance Company v. Arthur Farm Power Inc et al
as 2:2016cv02196
Plaintiff: Auto-Owners Insurance Company
Defendant: Arthur Farm Power Inc, Farm Pride LLC
Cause Of Action: Diversity-Other Contract
Brahler v. Kraft Heinz Food Company
as 1:2016cv06161
Plaintiff: George Brahler
Defendant: Kraft Heinz Food Company
Cause Of Action: Diversity-Product Liability
Jet Co, Inc v. Thor Industries, Inc et al
as 3:2016cv00243
Plaintiff: Jet Co, Inc
Defendant: Thor Industries Inc , Postle Operating, LLC
Cause Of Action: Petition for Removal- Product Liability
Lynch v. Motorola Mobility LLC et al
as 1:2016cv04524
Plaintiff: Douglas Lynch , Jariel Arias , Robert Mahon and others
Defendant: Motorola Mobility LLC , Lenovo (United States) Inc.
Cause Of Action: Magnuson-Moss Warranty Act
Forster et al v. Windsor Window Company et al
as 2:2016cv00480
Plaintiff: Todd Forster , Maria Forster
Defendant: Woodgrain Millwork Inc, Windsor Window Company
Cause Of Action: Diversity-Contract Default
Clark et al v. Windsor Window Company et al
as 2:2016cv00479
Plaintiff: Walter Clark , Stephanie Clark
Defendant: Windsor Window Company, Woodgrain Millwork Inc
Cause Of Action: Magnuson-Moss Warranty Act
CLARK et al v. WINDSOR WINDOW COMPANY et al
as 1:2016cv00721
Plaintiff: STEPHANIE CLARK, WALTER CLARK
Defendant: WINDSOR WINDOW COMPANY, WOODGRAIN MILLWORK, INC.
Cause Of Action: Magnuson-Moss Warranty Act
M.E.M. Ventures, LLC v. The White Group, Inc. et al
as 4:2016cv00023
Plaintiff: M.E.M. Ventures, LLC
Defendant: The White Group, Inc. , Steven White
Cause Of Action: Diversity-Petition for Removal
Barnett v. Sears Holdings Corporation
as 1:2016cv02430
Plaintiff: Terry Barnett
Defendant: Sears Holdings Corporation
Cause Of Action: Magnuson-Moss Warranty Act
Disclaimer: Justia Dockets & Filings provides public litigation records from the federal appellate and district courts. These filings and docket sheets should not be considered findings of fact or liability, nor do they necessarily reflect the view of Justia.


text:
Jensen AM/FM Cd Stereo with USB, Ipod control, Weatherband & Sirius - JMS7010
200 Watts (4X50w) IPX6 rated waterproof faceplate Fully sealed chassis USB feature allows connection of jump drive for digital music Full iPod control NOAA Weatherband Sirius Satellite ready Zero memory current draw Low battery warning 40 second CD skip protection Wired remote capable (JWR200) Multiple line LCD display US/Euro
Add to Cart and enter your Postal Code to determine the shipping charges and estimated delivery date.
Most products and orders leave our warehouse in 1 business day. However, select items may take more processing time. Alaska and Hawaii orders please add 1 additional warehouse processing day.
Standard Shipping Policies


text:
128GB Apple iPad goes on sale
Apple's new 128GB laptop-challenging iPads have gone on sale in the US and the UK on Tuesday, allowing people who like to store things to store even more.
The new model - which is exactly the same as the current Apple offering (don't panic there isn't an iPad 5 yet) - will offer users 128GB of storage space and cost $929 for the Wi-Fi + cellular version in the US and £739 in the UK.
READ: Apple iPad 4 (late 2012) review
Those who need Wi-Fi only will be able to buy the new larger storage sized model for £639 in the UK and $799 in the US.
Although the online store is now listing the new models, the buy it now button says 1-3 days availability.
Will you be buying the Apple iPad 128GB model?
Best smartphone battery packs: Pokemon power and more
Huawei MateBook review: 5-hours of friendship
Razer has a new iPad Pro mechanical keyboard case for gamers
Here are all the iPhones, iPads, and Macs that won't run Apple's betas
- Huawei MateBook review: 5-hours of friendship
- Razer has a new iPad Pro mechanical keyboard case for gamers
- Kindle's Page Flip lets you skip pages without losing your place
- New Amazon Kindle 2016: Double memory, thinner, lighter and more
- Samsung Galaxy TabPro S review: Taking on the Microsoft Surface Pro
- Life-drawing at the Royal Academy with an iPad Pro
- Win an iPad Pro worth £500 with Travelex Supercard!
- Nvidia might have new Shield gaming tablet on the way, FCC filings reveal
- EE Jay is a fun and budget-friendly 4G tablet for summer travelling
- Next Apple Pencil could have swappable tips and even Touch ID
- Pokemon Go Gym tips: How to battle, train and win
- Pokemon Go: How to raise your XP level, power up and evolve your Pokemon
- Help! Pokemon Go isn't working: How to fix common Pokemon Go problems
- Pokemon Go: How to play and other tips and tricks
- BlackBerry DTEK50 vs BlackBerry Priv: What's the difference?


text:
Templo Romano
Casas Pintadas
Painted on the garden walls of an open vaulted gallery are a series of unusual 16th-century murals that were once part of a noble's...
Fórum Eugénio de Almeida
In a building that once housed the Holy Office of Inquisition, this centre of arts and culture hosts some of Évora's most...
Igreja de São João
The small, fabulous Igreja de São João, which faces the Templo Romano, was founded in 1485 by one Rodrigo Afonso de Melo, count of...
Right in Évora's medieval heart, this bar has a pretty tree-shaded patio for nursing a glass of Alentejo wine. The food is pretty good...
Largo do Conde de Vila Flor · interesting places nearby
Templo Romano information
Once part of the Roman Forum, the remains of this temple, dating from the 2nd or early 3rd century, are a heady slice of drama right in town. It's among the best-preserved Roman monuments in Portugal, and probably on the Iberian Peninsula. Though it's commonly referred to as the Temple of Diana, there's no consensus about the deity to which it was dedicated, and some archaeologists believe it may have been dedicated to Julius Caesar.
How did these 14 Corinthian columns, capped with Estremoz marble, manage to survive in such good shape for some 18 centuries? The temple was apparently walled up in the Middle Ages to form a small fortress, and then used as the town slaughterhouse. It was uncovered late in the 19th century. Obviously these unwitting preservation techniques worked, as the imposing colonnade is stunningly complete.


text:
From Me, With Love
Shannon Pearce
This book is available for download with iBooks on your Mac or iOS device, and with iTunes on your computer. Books can be read with iBooks on your Mac or iOS device.
Two Erotic Romance Stories
Married Until Monday: Trips to the cabin were the best of times for Thom and Julius. They went as often as they could, when time away from their stressful careers would allow. Thom had loved Julius since college. Thom had never told Julius that he was gay, but thought that he had to have known. Thom had many gay friends, and a few lovers. It is not until the two of them are well entrenched in their careers that Julius begins to have relationship problems. When his girlfriend leaves him, Julius turns to Thom. Thom's suggestion that they get away to their favorite cabin for the weekend is more than welcomed by Julius, but Thom is surprised by his friend's latest revelation. Kevin and Andy: Time together had made Kevin and Andy friends and confidantes, with a palpable sexual tension between them which was always carefully cloaked in friendly banter. Since Andy's divorce, the two of them have not seen each other nearly as often as they once had, and both missed this time together. With Kevin's wife out of town for the weekend, the two of them will now have a chance to catch up.
Customers Also Bought
- $0.99
- Category: Erotica
- Published: Sep 08, 2010
- Publisher: Beau to Beau Books
- Seller: Beau to Beau
- Print Length: 20 Pages
- Language: English


text:
Cornucopia Wine Quest
October 15th-30th. (Saturdays and Sundays Only)
During this signature event, guests will have the opportunity to travel to 16 wineries over two weekends to experience our progressive festival! Each winery will allow guests to enjoy a unique element of the Quest at each winery (see below), while also sampling the handcrafted wines of that winery.  Each guest will receive a souvenir glass to take to each participating winery and will receive a 10% discount on all purchases. You will be able to enjoy a variety of foods by local street vendor concessions hosted by many of the wineries on site.
Participating wineries will be announced soon
For information concerning group excursions, please click here.


text:
Stars video https://youtu.be/wZtNOEg01tc Star is a beautiful, personable, and kind all-around gelding that is able to be maintained at home. He is suitable…$37,500
Meet "Red Bug"! Yes, he is a cutie! Little male foal - arrived in mid April! He has been: * haltered * wormed * loaded & hauled with his dam * to…$350
9 year old grade paint gelding. Was sent to trainer December 2015 for barrel training. He knows the pattern well and just needs to be pushed. Without pushing…$3,000
Sequin "Sheza Wright Sequel" APHA 11 year old mare, easy going, laid back simple horse, 15.2 H. She was shown as a yearling halter and lounge line, 2 year…$2,500
Sam is a 5 year old AMHA stallion 33 inches Sire is an own son Of Lazy Ns Boogerman and dam a Rowdy bred mare. Great driving potential, also jumping. Very…$875
Italy is a 14.1HH four year old, half arab, chestnut overo gelding. Italy can be registered with the CAHR and the Canadian Pinto Horse Association. …$5,000 CAD
very athletic needs a confident experienced rider and need some confidence building but shows amazing potential contact chloe 306 8505685$3,500 CAD
ridden only english could go any direction needs an intermediate rider. great little mare.$4,000 CAD
Gainesville, TX


text:
Free personalized radio that
plays the music you love
Poems Hindous (4) For Soprano & Ensemble: Bénarès: Naissance De Bouddha
Features of This Tracka Modern style
a large chamber ensemble
harp playing
a mezzo-soprano
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
Similar Tracks
Don't have a Pandora account? Sign up
Already have a Pandora account? Log In


text:
HIMSS (Healthcare Information and Management Systems Society)
The Healthcare Information and Management Systems Society (HIMSS) is a nonprofit organization whose goal is to promote the best use of information technology and management systems in the health care industry.
Download Our Guide: mHealth Security Best Practices
There's no doubt that mobile health technology improves patient care, engagement, and physician productivity. But, the security risks are vast. Learn how to protect your mHealth devices and data in this exclusive e-guide.
By submitting your email address, you agree to receive emails regarding relevant topic offers from TechTarget and its partners. You can withdraw your consent at any time. Contact TechTarget at 275 Grove Street, Newton, MA.
You also agree that your personal information may be transferred and processed in the United States, and that you have read and agree to the Terms of Use and the Privacy Policy.
Founded in 1961, HIMSS provides a forum for collaboration among the various stakeholders in health care IT, using advocacy, education and collaboration to further its mission. Its membership base of more than 44,000 individual and 570 corporate members includes health care providers, students, IT vendors, consultants and other stakeholders in the health IT industry. HIMSS currently focuses its attention on health IT topics such as electronic health record systems, HIPAA security and privacy provisions, software interoperability and technical standards.
HIMSS produces an annual conference that brings together health IT stakeholders for several days of education and networking. The organization also offers a research arm known as HIMSS Analytics and a philanthropic group known as the HIMSS Foundation.
Learn more:
The HIMSS website provides resources on key topics and links to professional development opportunities.
SearchHealthIT.com has a page devoted to its coverage of HIMSS10, the organization's most recent conference.
Officials offer update on health IT adoption at HIMSS 2011.
HIMSS board chair discusses progress of the EHR incentive program.
Continue Reading About HIMSS (Healthcare Information and Management Systems Society)
Dig Deeper on Establishing interoperable electronic health systems
Find more PRO+ content and other member only offers, here.


text:
Loss of Lives in Clinical Trials...
Keep the Opportunities, Lose the Opportunists
Capitol Hill Critics Second-Guess Agencies Using...
Researchers Now Have a Myriad of...
Ligand Pharmaceuticals is to acquire Metabasis Therapeutics for about $1.8 million net in cash plus four tradable contingent value rights (CVRs) per Metabasis share. The gross cash payment by Ligand has been set at $3.2 million and takes into account Metabasis' net liabilities at closing and an amount to be deposited in the stockholders' representative fund.
The CVRs will entitle holders to additional cash payments relating to milestones, royalties, saleback, or licensing agreements linked to Metabasis' existing projects including its HCV collaboration with Roche, its thyroid receptor beta-related hyperlipidemia and diabetes programs, the MB07133 product for hepatocellular carcinoma, and the company's equity interest in PeriCor Therapeutics.
Ligand has also committed at least $8 million in R&D funding for the Metabasis pipeline within 42 months following completion of the acquisition. Ligand president and CEO, John L. Higgins, claims the deal's creative structure will be beneficial to both companies.
"Ligand obtains numerous high-quality partnered and development-stage programs that will increase our revenue potential and expand our pipeline of proprietary assets. In exchange, the nonpartnered Metabasis programs will be advanced by a company with strong and proven research credentials, with the goal of generating cash proceeds payable directly to Metabasis stockholders." Metabasis has been leveraging its technologies to develop new drugs for metabolic and liver diseases. In addition to a number of discovery-stage projects, the company's in-house clinical pipeline includes the diabetes candidate MB07803 (Phase II), a thyroid receptor beta agonist (MBO7811) for the treatment of hyperlipidemia (Phase Ib), MB07133 in primary liver cancer (Phase I/II completed), and hepatitis B candidate Pradefovir (Phase IIb completed).
Metabasis' discovery programs hinge on its HepDirect® and NuMimetic™ technologies. HepDirect is a prodrug technology designed to target drugs to the liver. In addition to its use for in-house drug development, the platform is also being exploited through collaborations with Merck & Co. and Idenix.
The NuMimetic technology has been developed for the discovery of molecules that target liver enzyme nucleotide-binding sites. The platform includes a library of nucleotide mimetics for use in the discovery of novel compounds with potential against pathways involved in metabolic diseases. Besides its in-house use, the NuMimetic technology has also been leveraged as part of Metabasis' collaboration with Merck to discovery new AMP protein kinase (AMPK) activators. In June the company announced that this four-year research collaboration yielded a lead preclinical candidate.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today's life science tools and technologies.
You're all set! Thank you for subscribing to GEN Highlights.
MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
Induction of labor in toxemia with misoprostol
Address for correspondence:
Guler Sahin
Yuzuncu Yil Universitesi Tip Fakultesi
Kadin Hastaliklari ve Dogum Anabilim Dali
e-mail: firstname.lastname@example.com
Background. To compare the efficacy and complications of intravaginal misoprostol application with oxytocin infusion for induction of labor in toxemia of pregnancy with a modified Bishop score of ≤4.
Methods. A hundred preeclamptic women with a modified Bishop score of ≤4 were randomized into two groups of 50 patients one group receiving 50 μg intravaginal misoprostol 4 times at 4 hour intervals, the second group receiving oxytocin infusion for induction of labor starting from 1 mIU/per minute, increasing it every 30 minutes with 2 mIU/per minute increments up to maximum of 30 mIU/per minute. Modified Bishop scores 12 hours after induction, the time from induction to delivery, the route of delivery, fetal outcome and maternal complications were recorded. Statistical analyses were performed using Mann Whitney-U, Chi-Square and hypothesis tests about differences for two proportions (t test) to determine differences between the two groups. p≤0.05 was considered significant.
Results. Misoprostol was significantly superior for induction of labor in toxemia of pregnancy with modified Bishop score of ≤4. After 12 hours median modified Bishop scores of misoprostol administered group and oxytocin administered group were 7 and 4 respectively. Misoprostol administered group 1 was significantly better than oxytocin administered group 2 (p=0.027). The rate of patients who were in labor after 12 hours were 94% and 80% in group 1 and 2 respectively and the difference showed significant difference (p<0.05). The median time from induction to delivery was 14 hours and 16 hours in the misoprostol and oxytocin administered group respectively with significant difference between the groups (p=0.003). The rate of vaginal delivery was significantly higher in the misoprostol administered group 1 (82%) when compared with the oxytocin administered group 2 (66%) (p<0.05). The 1 and 5 minutes median Apgar scores were 5–7 and 6–7.5 in group 1 and 2, respectively with no significant differences between the groups (p=0.96, p=0.64). The rate of admission to neonatal intensive care unit was similar in both groups. The complication rates were similar in all groups and no significant detrimental effects were noted.
Conclusions. Intravaginal misoprostol is an efficacious, cheap and safe method of induction of labor in toxemia of pregnancy with modified Bishop score of ≤4.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.


text:
With the free-trade agreement between China and the Association of Southeast Asian Nations in effect, businesses in the smaller countries are worried about a possible influx of inexpensive Chinese goods. Robert Sutter of Georgetown University found that ASEAN's trade deficit with China is matched by a trade surplus with the U.S., indicating that trade between China and ASEAN might simply be part of the global supply chain that exports to the U.S. and other Western markets.
Full Story:Economist (free content), The


text:
Consultant Editor Anne Sheasby spent several years working as a professional home economist within the food industry in a variety of roles before embarking on a successful freelance career in 1991 as a food writer and home economist. Anne is the author of many published cookbooks, covering a wide variety of subjects. She has also written for national magazines and regularly works with leading companies within the food industry. Anne is a member of the prestigious Guild of Food Writers and the Institute of Consumer Sciences.
The Ultimate Soup Bibleby Anne Sheasby
View All Available Formats & Editions
The book opens with an essential guide to soup ingredients, flavorings,
This lavishly illustrated volume is the ultimate guide to soup-making, with mouthwatering recipes from around the world. A mixture of traditional classics and exciting new ideas, there is something for every taste, diet and occasion, from hearty one-pot meals to elegant entertaining.
The book opens with an essential guide to soup ingredients, flavorings, techniques and equipment. This is followed by instructions for making your own basic stocks, thickening soups and making creative garnishes.
The recipe section has easy-to-follow step by-step instructions and photographs, with a glorious picture of each finished dish. The soups are divided into chapters according to their style and ingredients: chilled, light and refreshing, hot and spicy, creamy vegetable, chunky vegetable, winter warming, legume, pasta, noodle, tofu, chicken and duck, meat, fish, shellfish, egg and cheese, traditional country soups, one-pot meals and soups for entertaining.
Great soup recipes from around the world include Avgolemono and Bouillabaise from the Mediterranean, Irish Brotchan Foltchep and Scotch Broth from the British Isles, Thai classics such as Cellophane Noodle Soup and Chiang Mai Noodle Soup, chilled Spanish Gazpacho and fiery Malaysian Laksa Lemak.
Consultant Editor Anne Sheasby spent several years working as a professional home economist within the food industry in a variety of roles before embarking on a successful freelance career in 1991 as a food writer and home economist. Anne is the author of many published cookbooks, covering a wide variety of subjects. She has also written for national magazines and regularly works with leading companies within the food industry. Anne is a member of the prestigious Guild of Food Writers and the Institute of Consumer Sciences.
Product Details
- 9780760774496
- Publisher:
- Sterling Publishing
- Publication date:
- 11/07/2005
- Pages:
- 512
- Product dimensions:
- 9.20(w) x 11.70(h) x 1.70(d)
Meet the Author
Customer Reviews
Average Review:
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >
I picked up the gem for EIGHT dollars and change from the bargain book bin and I LOVE it! I'm a big time soup lover and can't get over how many delicious recipes contained in the tome. I'm planning on going back to the book store to buy another one as a gift or my mother!
I received this book as a gift and so far am loving it. Not only are the recipes well explained and delicious to boot, but they're also illustrated in full color. For such a low price I'd recommend you buy one for yourself and for a friend!
Easy to follow instructions and with a lot of very helpful photos. Buying more for friends and family.
I spotted it one day while at Barnes & Noble and whispered my desire to get it to my Husband. He later surprised me with the book. It is fantastic! I am a soup lover and regularly make the usual home-made chicken soup, Emeril's meat ball soup, chili, beef with vegetable. This book, however, had my full attention from the get go. It has introduced me to new forms of making soups, enabled me to discover new ways to use everyday fruits and vegetables and motivated me to try new vegetables like parsnips, butternut squash, turnips, etc. in soups. So far I have sampled 3 new recipes and they were all delightful! Talk about "playing with my food". Thank you!
Great book, would buy it again anytime for me or any friend of mine
I love to make soup and this is my go-to recipe book. The recipes are easy, there are "millions" of them, and best of all every single one comes with a photo.
The recipes are really easy to read and understand. The photos are mouth watering! Purchase a copy for yourself and you will see.
I adore making soups even in the summer; this book is fabulous. A must have for a real cook. I adore it.
A colorful, beautifully-pictured Soup recipe book--great for gift giving or your own recipe library. Most soups have practical, easily sought out ingredients.
Through the generosity of a chef at Santropol Restaurant in Montreal, I obtained the name of this cookbook after asking for a delicious soup recipe I had enjoyed at their restaurant in The Plateau near McGill University. It has great photos of each soup, clear directions, healthy and delicious easy-to-follow recipes. I highly recommend it!
The 'Soup Nazi' has nothing on this book! This is, by far, one of my most cherished cookbooks. An amazing array of recipes broken down into easy to navigate categories, like, 'Pasta Soups', 'Fish Soups' Hot & Spicy Soups', etc. Pictures are plentiful and very attractive. I have given it as a gift to several friends and always get asked for the recipes for the soups I serve when entertaining. You won't be disappointed....buy two, I promise you'll have an occasion to give one away!
The Ultimate Soup Bible, is an outstanding cookbook that is both easy to follow and the recipes are fantastic! Get your copy today!
I received this book as a gift. It is by far my favorite cookbook. I use it almost weekly and have also given it as gifts to friends and family. The book is full of colorful pictures and easy to follow recipes that taste delicious. You won't be disappointed!
I believe I have given away around 10 copies of this book. I will make a soup from the book, I will get complements, and then I will go to my stockpile and give a few more copies away. (Full disclosure - it often makes it into the store bargain bin where I will buy all copies at $6 each). It is a definitive soup cookbook with a wealth of pictures and great flavors. I never made soup from scratch until I got this book - now I feel like an expert. Buy this book!
I love soup all year 'round. And here's the perfect launching pad. This huge volume has hundreds of soup receipes with yummy pictures, and covers everything from cold soups to veggies to meats to one pot meals to fancy soups for entertaining. I'm an intuitive cook and I don't follow directions well, but I do find that these recipes are great for guidance. Some of the instructions are a bit hard to follow (especially when there are 2 components to the dish), but one can figure it all out. Right now, the Roasted Garlic and Butternut Squash soup is simmering on the stove. The salsa is chilling in the fridge and dinner is just about ready! A great bargain!


text:
Booked for 2-nites based on price/location. Were not disappointed based on this criteria. John was welcoming and entertaining. Wife is, by her admission, "a posessed baker", and had many baked goods at breakfast. Place is very clean!! Location is 2-blocks from downtown shopping and dining.
We had the cheapest room, in the basement, basic to say the least. Bathroom 20 feet away, which was fine. The only real problem here is no common area to hang out and read and relax, as owner occupy the main floor area to eat and ave TV on, loud.
Appears amny europeans stay here, we had France, Dutch and Swedes staying while we were there.
So, if you are looking for basic, good location and good price and breafast, but not atmosphere, then this works.


text:
water treatment Companies serving Congo, Democratic Republic of the
Current filtering criteriaYou can remove a filter by clicking on the x
Keyword: water treatment ×
Industry: Energy ×
Serving: Africa ×
Serving: Congo, Democratic Republic of the ×
Anguil Environmental Systems, Inc.
based in Milwaukee, WISCONSIN (USA)
Anguil Environmental Systems is a global provider of industrial air pollution control, emission abatement and energy recovery systems. We design, manufacturer, service and install thermal and catalytic oxidation technologies as well as heat recovery systems for a variety of applications and industries.Anguil Aqua was developed to help our industrial clients with water ...
based in Ludwigshafen, GERMANY
Kurita Europe is a subsidiary of Kurita Water Industries Ltd. headquartered in Tokyo (Japan). Founded in 1949, the Group has 5,400 employees worldwide as of 2015 with a turnover of approximately USD 1.8 billion. Over 3,500 patents are proof of Kurita's innovative approach to a resource-saving consumption of water.
DMT Global Environmental Solutions BV
based in Joure (NL), NETHERLANDS
DMT Environmental Technology is a fast growing company that specializes in helping companies to contribute to the environment in a sustainable and profitable way. The techniques we implement solve environmental issues. With over more than 28 years of experience, DMT is reliable partner and market leader in the field of biogas upgrading, for which we apply advanced ...
Canadian Crystalline Waters India Ltd
based in UAE, UNITED ARAB EMIRATES
Established in the year 1969, at Chennai, we Canadian Crystalline Water India Ltd, have inched forward as well recognized manufacturers and exporters of advanced technology based water purifying plants & other allied products. Our more than 5000 turkey projects have been supplied in many countries including India, Middle East, South East Africa, Australia, Sri Lanka, USA, ...
Derwent Water Services Ltd
based in Alfreton, UNITED KINGDOM
Derwent Water Services has established itself as a leading manufacturer and supplier of quality water treatment plant, ranging from basic water softeners and reverse osmosis equipment to customer specified complex water treatment solutions. Its success is due to its flexibility in tailoring its quality products to meet customer requirements. Derwent provides several ...
TREVI nv
based in Gentbrugge, BELGIUM
Trevi environmental consultancy and technology is a Belgian company founded in 1992 by the present directors. The company is directed by Stefaan Deboosere and Jacky Mortelmans and has a team of about 100 employees with different specialties including environmental consultants, process experts, programmers and installers. This wide expertise offers the client the advantage ...
Napier-Reid Ltd.
based in Toronto, ONTARIO (CANADA)
Napier-Reid Ltd. is a leading engineering designer, manufacturer and solution provider for the water and wastewater treatment industry. With over 50 years of experience, the successful completion of over 3000 projects worldwide, a core team of professionals and highly skilled staff, we continue to grow and reach new heights every year. With in-depth engineering knowledge ...
Alfa Laval
based in Sweden, SWEDEN
Alfa Laval is a leading global provider of specialized products and engineered solutions. We work to sell specialized products and engineering solutions in order to optimize the performance of our customers' processes. We market and supply a broad range of filters, heat exchangers, separators, decanters, pumps, valves and fittings to customers in a wide range of market ...
Kemira Water Solutions, Inc.
based in Bartow, FLORIDA (USA)
Kemira is committed to being a leading water chemistry company. Our strengths are high-level application know-how, a comprehensive range of water and wastewater treatment chemicals, and reliable customer deliveries. As a leading global provider of inorganic coagulants and organic flocculants, we offer an extensive portfolio of products that also includes biocides, ...
Endress Hauser Instruments International AG
based in Reinach, SWITZERLAND
Endress Hauser is a global leader in measurement instrumentation, services and solutions for industrial process engineering. The Group employs more than 12,000 personnel across the globe, generating net sales of 2.0 billion euros in 2014. Water quality, discharges, regulations, the environment… just rely on a trusted partner. No resource is more precious than water. But ...
SnowPure Water Technologies
based in San Clemente, CALIFORNIA (USA)
SnowPure Water Technologies manufactures and supplies an array of water purification and process components directly to system integrators in 55 countries. Our technologies include: Electrodeionization (EDI), Power Supplies, Nanofiltration (NF), Ultrafiltration (UF), Reverse Osmosis (RO), Ion-Exchange Membranes, Electrodialysis (ED), Ultraviolet (UV), and Gas-Transfer ...
Burns & McDonnell
based in Kansas City, MISSOURI (USA)
Burns & McDonnell, headquartered in Kansas City, Mo., is a full-service engineering, architecture, construction, environmental and consulting solutions firm. Our multidisciplined staff of more than 4,300 employee-owners includes engineers, architects, construction experts, planners, estimators, economists, technicians and scientists, representing virtually all design ...
Canamidex International
based in Richmond Hill, ONTARIO (CANADA)
We provide engineering, design, procurement, and construction services to the water and wastewater treatment and transfer Industry.We have a strong alliance with international manufacturers, who allow us to provide customized end- to-end turnkey solutions suited to our customer's requirements.Today we specialize in, Water Treatment, Waste Water treatment and reuse, Sludge ...
IWA Publishing
based in London, UNITED KINGDOM
IWA Publishing`s vision is to be the leading international membership association for the improvement of urban water management worldwide in an environmentally sustainable way. Specifically, IWA Publishing`s coverage includes all aspects of water supply and treatment, wastewater collection, treatment and disposal and overall management of water quality and quantity ...
SIMPEC S.r.l.
based in Nova Milanese (MB), ITALY
Simpec works in the design, construction, installation and service of industrial water and wastewater treatment plants. Main sector of the company is metal and plastic surface finishing treatments. Simpec works for all the industries that use and consume water in their different production processes. Simpec realizes also plants for landfills (leachate treatment), plants ...
Advanced Water Treatment Technologies Services (AWTS) Inc.
based in Plano, TEXAS (USA)
AWTS has been serving Industrial and Municipal customers, with large scale water treatment plants, both high purity and waste water treatment, Zero Liquid Discharge facilities and hydraulic frackiing processes. We specialize in all types of technologies including pretreatment clairification, filtration, RO, UF, MF membrane processes, degasification systems, chemical ...
Flow Water Technologies Ltd
based in Tremithousa, CYPRUS
Flowwater Technologies Ltd. is an international water management and treatment company whose mission is to `bring water to life` through more effective, lower cost and reduced energy methods of water conditioning, cleaning and sanitisation.
Turner Designs Hydrocarbon Instruments, Inc.
based in Fresno, CALIFORNIA (USA)
Turner Designs Hydrocarbon Instruments, Inc. are specialists in the measurement and monitoring of oil in water. We are experts in the application of UV Fluorescence technology to the monitoring and analyzing of produced water and other oily wastewater. We provide state-of-the-art continuous on-line oil in water analyzers as well as bench-top single sample analyzers. ...
Ludowici Water Pty Ltd
based in Carole Park, AUSTRALIA
Ludowici Water is an Australian Water Engineering Company: We design, manufacture and install products and solutions to control, transfer, treat and re-use water. Ludowici Water provide a centre of excellence for stainless steel fabrication and have the ability to offer innovative solutions across a wide range of products using latest technology and state-of-the-art ...
Modern Water - Monitoring Division
based in Cambridge, UNITED KINGDOM
Modern Water's Monitoring division has developed some of the world's most advanced systems for monitoring water quality. We provide market-leading toxicity monitoring systems, trace metal and environmental monitoring systems. The range includes systems for portable, online, and laboratory use. Our toxicity monitoring products, Microtox and Microtox CTM, detect toxins in ...


text:
More fish News
Strange Findings on Comb Jellies Uproot Animal Family Tree; 'It's a paradox'
Forum Rules
I am in the label printing business and I have a
salt water aquarium. I cam up with these labels
and ...
Welcome to Aquarium Home Farm Center, a
professional breeder of the Dragon Fish, the Asian
Red Arowa ...
I am the owner of Custom Acrylic Reef. We can
build your dream custom acrylic aquarium and then
set ...


text:
My husband and I are planning a 20 days vacation in Europe End of august with our 13 months old daughter. our flight is to and from Paris, so we were looking at several options, my husband really wants to see Amsterdam, and I would like to see south of France (Nice or Cannes).
We first came up with this route:
Paris-Nice by Train
Nice-Venice by Train
Venice-Vienna by train
Vienna- Amsterdam By Air
Amsterdam-Paris By train
then we thought it is too ambitious considering we have to spend at least 7 hours in the train between Nice- Venice- Vienna. and we didn't like the flight in the middle.
we figured that one of us has to give up his destination in order to make a full round using trains only so we made another route:
Paris-Bern-cologne-Amsterdam-Paris. which is not that interesting to me.
considering that I have been to Bern,Genoa,Milan,Florence before, I wouldn't want to stop in them again, although I wouldn't mind Bern.
we've traveled with our daughter when she was 10 months old and she was very relaxed and sleeping on most of the flights/buses, and even during our walks in the city.
Any Thoughts or suggestions on how we can plan it would be appreciated.
Recent ActivityView all Europe activity »
- 1 Rome & Florence, 10-12 days or so
- 2 What neighborhood to stay in Paris?
- 3 Day Trip from Lausanne
- 4 Suicide bombing in Ansbach
- 5 Barcelona Car rental return
- 6 From London to Paris to US
- 7 France to stop making foie grois
- 8 My First Trip to Europe...
- 9 Base City for N Europe Layover
- 10 Lisbon ... Two days only ... Must see?
- 11 Amsterdam bike rides and maps
- 12 Night Walk, food and Shopping in Rome
- 13 Iceland in 9 nights in late September
- 14 Family of 4, 2 Young Teens, 14 Nights, 4 Countries
- 15 European countries thst could use some hospitality lessons.
- 16 Edinburgh Festival Fireworks
- 17 Sevilla to Cordoba Day Trip: How many hours needed?
- 18 Leipzig, Dresden, Meissen, Bautzen, etc.
- 19 Naples or Genoa
- 20 Has anyone used their Pass Navogo for more than 10 years?
- 21 First time Europe trip for family of 4
- 22 Dover queues
- 23 French Gov't Passes New Labor Law Despite...
- 24 How did you or your family ended up in the country you are living now?
- 25 Who is up for an informal GTG in Paris between Oct 15-22
Touring Europe with 1 year old
Report Abuse
then we thought it is too ambitious considering we have to spend at least 7 hours in the train between Nice- Venice- Vienna. and we didn't like the flight in the middle.>
Cut out Nice and you can take an overnight train Paris to Venice - get a private compartment and relax - bring food and drink on board - save on the cost of a hotel night and travel time, even over flying.
Amsterdam to Paris is by Thalys trains - www.thalys.com and you can score deep discounts if you book REALLY far in advance - like months to guarantee these limited in number tickets but you can save $200 or so over just showing up and buying once there.
For lots of great info on European trains check these IMO superb sources: www.seat61.com - great info on discounted tickets; www.ricksteves.com and www.budgeteuropetravel.com - downlaod the latter's free online European Planning & Rail Guide for lots of rail itineraries in various countries.
<Paris-Bern-cologne-Amsterdam-Paris. which is not that interesting to me.> Well me either - Cologne to me is for most at best a few-hour stop to see the gargantuan Gothic cathedral right next to the train station - put your bags (and maybe kid!) in a station luggage locker - look around the church and Rhine boardwalk and go on to some place much nicer than to me blah modern Cologne (which I have spent weeks in off and on for business in the past).
Switzerland to me is the high Alps and not cities though pleasant as Bern and Lucerne, etc are - I'd say head for the hills and the fabulous Jungfrau Region around Interlaken. The dreamy Alpine wonderland perhaps etched in your minds' eyes - stay 3 or so relaxing days there.
Zurich to Amsterdam can also be done by overnight train.
Report Abuse
See Amsterdam and Nice. I believe you can fly non-stop between the two cities.
What might be fun is plan to spend 5 days in Amsterdam and 5 days on the Belgian coast, and then 10 days on the French coast.
Just keep it simple and have a nice vacation that gives both of you want you want, and keeps it simple with the baby.
Report Abuse
Don't do a circle - do open jaws flights - into the first city and out of the last to avoid wasting time getting back to paris.
Why not Paris, Amsterdam, Vienna, Venice and fly home form there? IMHO slower is better with a toddler who may not be happy being cooped up in a train for so many hours on multiple days.
Report Abuse
Yes open-jaw ducats often do not cost much more if any than a round-trip sometimes as the case with London cheaper to return or fly into another city because of their steep landing fees.
Report Abuse
If Amsterdam and Nice are priorities, and the Paris flights are already set in stone, then I'd suggest sticking to those three. cities. A week in each with your little one would be lovely.
Report Abuse
thanks guys for the information and suggestions.
Sign in to comment.


text:
List all words starting with sorbs
Only the word sorbs was found, nothing longer.
Some random words: oak ionogen jebel uintahite acapnia stoa khi
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
Privacy and Cookies Policy - Share - © Copyright 2004-2016 Morewords.com - 5.157mS


text:
Audio: Abbey Capital investor relations team
11th European Fund of Hedge Funds Awards 2012
Being a fund of commodity trading advisers (CTAs) means Abbey Capital's investor relations team has its work cut out providing education to investors on how these comparatively little-understood strategies work. While most hedge fund investors are fairly comfortable with equity strategies, CTAs are generally perceived as more complex and unfamiliar. The nature of CTA/managed futures funds, especially the trend-following ones that make up the bulk of the CTA universe, at first glance appears counterintuitive...
More on Awards
7 days in 60 seconds
Smart contracts, Brexit and sovereign risk
The week on Risk.net, July 22–28, 2016Receive this by email
Back to Top


text:
Ticket to "Romeo & Juliet"
Amphitheatre at The Japanese Garden at the Greater Los Angeles VA Healthcare Campus • Los Angeles, CA
Use between Tuesday, July 08 – Thursday, July 24
What you get
- See a Shakespearean Classic Live!
- Intimate Performances in July -- No Seat More Than 6 Rows from the Stage
- Come Early & Bring a Picnic Dinner
Enjoy a tale of timeless love live under the stars with this offer from The Shakespeare Center of Los Angeles, bringing the best of the Bard to town since 1986. This local institution presents "Romeo & Juliet" to the Amphitheatre at The Japanese Garden at the Greater Los Angeles VA Healthcare Campus on select dates in July, and you'll have your choice of performance. Directed by Kenn Sabberton (Shakespeare Center's "A Midsummer Night's Dream," "As You Like It"), this night of romance also invites guests to come early, bring a picnic, and dine in the garden before the curtain opens.
Choose from the following offers:
• $19 ($24 value) for one Tier 2 ticket
• $29 ($53 value) for one Tier 1 ticket
Shakespeare Center of Los Angeles' Website
Fine printREFUND POLICY: This event is nonrefundable. No full or partial refunds are given to customers who miss an event. In the event of a cancellation, your voucher will be fully refunded • Each voucher is good for 1 person • Performances begin at 8 p.m. Garden opens for picnics at 6:30 p.m. • The deal is valid only for tickets on the date[s] of the event as listed and may not be exchanged or redeemed for any other dates • Groups wishing to sit together must purchase their vouchers together • Purchaser may change the name of the individual retrieving tickets up to 24 hours in advance of event via the LivingSocial website event details section; no name-changes or alternate pick-ups permitted without notice at venue • Entire value must be used in a single visit
Other conditions apply
Except where noted in the fine print:
• Cannot be combined with any other offer or promotion
• Tax and gratuity are not included
• Merchant is responsible for the quality of the products or services provided to you at redemption
• LivingSocial Terms and Conditions - https://m.livingsocial.com/terms
Ticket to "Romeo & Juliet"
times for
More upcoming events
use by Dec 19
Escondido, CA
San Diego Zoo Safari Park: 1-Day Pass
San Diego Zoo Safari Park
use by Jul 31
Inglewood, CA
Ticket to Teen Choice 2016
The Forum
use by Nov 30
Los Angeles, CA
1-Year Membership to LA Zoo
Greater Los Angeles Zoo Association
Friday Aug 5
Los Angeles, CA
Ticket to Brew at the L.A. Zoo
Los Angeles Zoo & Botanical Gardens
use by Sep 4
Los Angeles, CA
Ticket to "Newsies" Musical
Hollywood Pantages
use by Aug 7
Los Angeles, CA
Orchestra or Mezzanine Ticket to "Cabaret"
Hollywood Pantages
Wednesday Jul 27 through Thursday Sep 22
Los Angeles, CA
LA Dodgers Baseball Tickets
Dodger Stadium
use by 2017
Buena Park, CA
Ticket to Pirate's Dinner Adventure
Pirate's Dinner Adventure
Nearby deals
Made Cleaning
2, 3, or 4 House of House Cleaning
LLC Cleaners
Up to 6 House-Cleaning Sessions
Racer's Edge Indoor Karting
16-Lap Go-Kart Race with Soft Drink
Chevoit Hills Tennis Center
Tennis Summer Camp
Laguna Canyon Spa
3-Hour Spa Package of Your Choice
LA Pro Cleaners
Deep House Cleaning
Skydive Coastal California
Tandem Skydive, T-Shirt + Video
Hornblower Cruises & Events
2-Hour Harbor Cruise Around San Diego


text:
With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
Make your own colored sugar
Sandwich , Put some drops of food coloring in the Sugar
Let the colored sugar dry And then let your creativity on the run !
Good Morning Snail!by klinong
Pumpkin Butter and "Ghoul" Sand Witchesby tjones5167
Banana Sandwich Sushi Rollsby Huang Kitchen
Suger Cube Artby limette
Bird's Nest Breakfast Sandwich (New Spin on an Old Favorite)by Gages Cooking Corner
Join 2 million + to receive instant DIY inspiration in your inbox.
Download our apps!
© 2016 Autodesk, Inc.


text:
Skip to Main Content
IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards,
eBooks, and eLearning courses.
Learn more about:
IEEE membership
IEEE Xplore subscriptions
The application of pulsed lasers to the study of Single-Event Effects (SEEs) in integrated circuits and devices is described. The role of a pulsed laser is to provide spatial and temporal information about SEEs, information that is not available when broad-beam ion sources are used. A detailed description is given of the mechanisms involved, including light propagation and absorption by both linear and non-linear processes. Numerous examples highlight the versatility and usefulness of the technique in the study of SEEs.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


text:
This, apparently, is Chicago month on the Spin Sucks Inquisition.
I am very, very lucky to live here because there are so many talented and smart people I get to see on a regular basis.
Rob Biesenbach is one of those people. Not only did he live down the street from me for years (he recently moved to Evanston), but he's a communicator by trade.
Rob, known for playing a doctor in ads and his red pants (which make an appearance in the video), is no stranger to Spin Sucks.
He has not only written for us (though I see it's been a couple of years!), he was a featured guest for our Author Q&A series when his latest book came out.
And here he is, on the Spin Sucks Inquisition, on video.
The Spin Sucks Inquisition
I asked Rob the normal questions (which you can find below):
- Tell us who you are and what you do.
- What is the biggest mistake you've made in the past six months?
- What is one of the biggest trends you'll be using this year?
- What is one thing about yourself that would surprise most people?
- What is the best book you've read in the last six months?
- What is your latest Netflix binge?
- The Five Second Rule
- Where can people find you online?
If you can't watch the video below, you can find it by clicking here.
Where You Can Find Rob Biesenbach
Go stalk Rob online, if you don't already do so.
You can find him on:
You can also read Act Like You Mean Business and 11 Deadly Presentation Sins.
Now the floor is yours.
Leave a Reply
16 Comments on "The Spin Sucks Inquisition: Rob Biesenbach on Video"
I'm naked, Rob shows us his red pants, and we talk about banging….we need to make sure to add this one to spinsucks.xx as well!
I couldn't quite believe the banging part!
Thank you, Paula! Yes, I have multiple items in my fridge with allegedly resealable ziplock-like closing mechanisms. And most either do not reseal, or when you try to open them, all the plastic around them rips open while the ziplock remains sealed. It bugs the HELL out of me!!
Here in SC, we call those red pants "go to hell pants."
I love that. Red pants have been a southern staple for years and now everybody's wearing them. I like that message, though.
Great interview, in spite of the weather in Chicago! I look forward to meeting you in Puerto Rico, Rob.
I share your view on "sustaining the learning after the event." Without coaching and follow-up, such events have, I believe, minimal value; yet with follow-up, they have tremendous value.
Thank you, Jack — glad you'll be there. I'm looking forward to it!
I think I'm just going to make the "sustained learning" a part of my proposals for now on instead of an optional add-on. It's not only too easy for participants to put the training "on the shelf" afterwards, but the client who hires me is often in the mode of, "That one's done, moving on to the next thing."
I have to say that when Laura popped on the screen I had a tiny, little panic attack. Apparently I have Inquisition PTSD.
And yay for Chicago! #allchicagoallthetime #okmaybenot
I can totally relate to the packaging temper tantrums. There's a lot of "ARE YOU FREAKING KIDDING ME?!?" that happens around here!


text:
Results 1 to 3 of 3
Thread: Modification concierge
Modification concierge
I don't understand some people. I get e-mails from people who want personal 1 on 1 e-mail assistance on what parts to buy and where to get them. What is so hard about "post on the forum" to understand?
The following message was sent to you via the BimmerBoost Contact Us form by Sam ( mailto:email@example.com ).
Hi. I've been looking at a white w204 coupe modified on your site. Was wondering if you could help me as I wanted to purchase the bonnet and bumper for me coupe? Please let me know. Thank you.
On 9 Oct 2012, at 02:39 AM, "GermanBoost.com" <firstname.lastname@example.com> wrote:
> Post on the site don't e-mail me...
> - Joseph - Admin - GermanBoost.com Network
I will. But can you tell me if it is possible to buy this kit
S. Makim
On 9 Oct 2012, at 09:44 PM, "GermanBoost.com" <firstname.lastname@example.com> wrote:
> Yes of course.
> - Joseph - Admin - GermanBoost.com Network
Where can I purchase the parts I need?
S. Makim
Look, these are questions for the forum post on it and please stop e-mailing
as I'm not a modification concierge.
- Joseph - Admin - GermanBoost.com NetworkFOUR SPOTS left in the BoostAddict NO MERCY Domination Fantasy Football league, CLICK HERE
Stage 2 or 2.5 E9X M3 S65 V8 supercharger kit for sale: http://www.boostaddict.com/showthrea...r-kit-for-sale
10-09-2012, 06:05 PM #2Member
- Join Date
- Aug 2010
- Location
- Valley Stream NY
- Posts
- 3,303
- Rep Points
- 2,757.4
- Mentioned
- 85 Post(s)
- Rep Power
- 28


text:
Why Invest in Wood Energy?
- On a global scale, it is renewable, carbon neutral and reduces reliance on fossil fuels
- On a regional scale, it creates local, rural jobs that cannot be outsourced and keeps energy investment in Michigan
- On a personal scale, it saves you money every month on your heating bills
The waste heat from U.S. power generation exceeds the combined total national energy use in all but three of 216 countries. One could think that this is an important problem. It's also an avenue for great opportunity.
How Can Wood Energy Work for You?
Read about potential advantages in a one-page document.
In Your Home
In Your Workplace
In Your Community
In Your Region
About the Michigan Wood Energy Team
The Michigan Wood Energy Team assesses Michigan's woody biomass supplies, energy infrastructure, and community readiness related to wood energy. We also provide educational resources related to the use of wood energy in Michigan, and provide supporting materials for the installation of demonstration systems for wood energy combined heat and power or district heating and cooling systems at the institutional or small community scale. Learn more about our mission and our members.
Related News
Uphill battles
March 8, 2016 | Bill Cook | Wood-based district energy grids and wood-based home/commercial heating are the lowest hanging fruits on the renewable energy tree. Michigan offers huge potential to benefit thousands of citizens, hundreds of businesses, communities and the environment.
Does it get any cleaner
August 6, 2015 | Bill Cook | Wood energy, an efficient and affordable technology, is one of the most environmentally-friendly energy sources at our disposal. It is renewable and sustainable, but it's locally-sourced and contributes to the heating and cooling sector.
Wood energy revisited
April 13, 2015 | Bill Cook | Following a cold winter, now might be the time to consider heating with wood. Wood heat technology goes far beyond the common smoke-belching outdoor burners. It is an efficient, dependable, low-cost alternative to fossil fuels.
Wood energy challenges
September 3, 2013 | Bill Cook | Renewable energy discussions often exclude wood as a feedstock. Yet, in many ways, wood has many advantages.
Wood energy technologies
July 8, 2013 | Bill Cook | Wood-based energy production will continue to be a major element in renewable energy strategies, especially in the northern Lake States region.
Wood energy plantations
June 19, 2013 | Bill Cook | Accelerated growth and local proximity are potential great advantages in wood energy trends.


text:
Charming Liars are a LA based Rock Band with London roots. The band is out on the road touring across North America with Black Audio and Night Riots. Glide's Amy Harris was able to catch up with the band for a few days on the road thru the Midwest with stops at the Turf Club […] The post Day in the Life with Charming Liars (PHOTOS) appeared first on Glide Magazine.
Riot L.A. (various venues, downtown Los Angeles, Friday through Sunday). Los Angeles is a city of comedy. It's not the only city of comedy – there are New York and Chicago (and Toronto and London, among other places where English is spoken). There is comedy practiced everywhere – given the minimal...
Late last year, we revealed that Titan Comics would be returning to Rivers of London, Ben Aaronovitch's supernatural detective novels (initially known as Midnight Riot in the US), with a new miniseries. But what actually happens when Russian gangsters go on the hunt for a powerful witch in police custody? io9 has a first look! Read more...
LONDON (Reuters) - British Prime Minister David Cameron's policy chief apologized on Wednesday after a newly released memo from 30 years ago revealed he had blamed poor morals in the black community for riots and said any investment would be wasted on discos and drugs.
Riots, legal battles and even a kidnapping: it's been a tough year for Uber. ||| Paris - From London and Paris to New Delhi and Sao Paulo, traditional taxi drivers united worldwide against Uber in 2015, a year that saw riots, legal battles and even a kidnapping in protest against the startup. Show More Summary
From London and Paris to New Delhi and Sao Paulo, traditional taxi drivers united worldwide against Uber in 2015, a year that saw riots, legal battles and even a kidnapping in protest against the startup. Since first winning customers in San Francisco five years ago, Uber has enjoyed spectacular...
Basil Jarvis left the Caribbean for West London 50 years ago, and has blasted soca sounds onto the streets of Notting Hill every year since.
LONDON — So today is Black Friday, and that can only mean two things: (1) shops across the country slashing their prices in the annual tradition made famous in the U.S., and (2) various members of the public rioting, scrapping and pretty...Show More Summary
A device that allows loved ones in long-distance relationships to listen to their partner's heartbeat has been launched on crowdfunding platform Kickstarter today by a London startup. Little Riot, a Telefonica-backed company, is looking...Show More Summary
Activists set a police car alight and scuffled with officers in riot gear in central London as thousands took part in a "Million Mask March" anti-capitalist demonstration on Thursday night. Many activists wore the white masks associated with the international Anonymous network at the...
LEFTISTS RIOT IN LONDON – ATTACK POLICE Leftists torched cars in London. BREAKING: Chaos escalates at the #MillionMaskMarch in London. pic.twitter.com/dA354kRUTu... The post BREAKING: Leftists RIOT – CLASH with Police at Million Mask March in London appeared first on The Gateway Pundit.
LONDON — The UK explodes into a riot of oranges, reds and yellows each autumn, as summer bids us farewell and trees of all shapes and sizes shed their leaves ahead of the approaching winter. From Westonbirt Arboretum in Gloucestershire to Nottingham's Sherwood Forest, the country's annual display rivals anywhere in the world. Show More Summary
There have been a growing number of anti-gentrification protests in and around London lately. They've also been getting louder, angrier, and in the case of the recent #fuckparade riots, more violent. read more
The London "bemusement park" wraps up in style.
Lush Cosmetics, known for their organic products that are not tested on animals—particularly their bath bombs—is getting some unwanted attention from some London residents, who are offended by an incense they've created called Lavender Hill Mob, which was "inspired" by the aftermath of the 2011 London Riots. Read more...
Photo via Banksy Dismaland's Facebook Banksy will mark the launch of his very own "bemusement park" in Weston-super-Mare, London, with a series of live performances, NME reports. Dismaland's musical entertainment begins on August 28, with DJ Yoda and Peanut Butter Wolf performing alongside Breakbeat Lou. Show More Summary
Video explores.
In London, taxi drivers are not rioting and burning Uber cars like we've recently seen in Paris. Instead, they are enlisting the likes comedian Russell Brand who sides with London's black cabs in an 8-minute video that's making the rounds in social media this week. Show More Summary
Pussy Riot are presenting an impromptu guerrilla gig of political speech and post-punk music with Thurston Moore.


text:
Mohsni's Best Position? No Idea!
Friday, 30th Nov 2012 09:00
Mick McCarthy admits that he doesn't yet know loanee Bilel Mohsni's best position. The Southend man, who has made five substitute appearances for the Blues during his three-month spell, was primarily a central defender with the Shrimpers but has also operated up front and in midfield.
McCarthy said: "I don't know! You're asking me something I don't know and I haven't found anyone else who actually knows. Billy doesn't know himself!"
The French-Tunisian was the unlucky sixth domestic loanee left out of the squad for Tuesday's game against Nottingham Forest but McCarthy says there are no thoughts about sending him back to Roots Hall: "He's got to hang around until anything changes because he's here until January. There's nothing going to happen on that.
"We might get an injury to some of the loan players and he might have to be involved. Sadly, that's the position we're in, we've got those loan players and he has to miss out."
Meanwhile, left-back Kelly Youga, who joined the Blues on a short-term deal recently, was involved in a practice match at Playford Road on Wednesday: "He's doing all right," said his manager.
"He's had a long-term injury. We had a bit of a game here yesterday amongst the players and he did OK.
"But that's a shot in the dark, just a punt. If he gets himself fully fit and he can play, he will be an option. If he doesn't, it'll be nothing ventured, nothing gained."
Town are without an U21 game in which fringe players such as Mohsni and Youga can play – three overage outfielders plus a keeper are permitted – until they visit Charlton on January 14th and McCarthy says the club will be arranging some friendlies between now and then.
Get a free £25 matched bet on Ipswich Town v Barnsley (or other matches) by opening a new account at William Hill. Place an initial bet of a minimum of £5 and William Hill will match that bet up to £25. You must enter the promotional code "F25" when signing up as a new customer.
Please report offensive, libellous or inappropriate posts by using the links provided.
You need to login in order to post your comments
Recent Stories
Blogs 207 bloggers
Tractor Boy on a Mission by wadey
As some of you may know, on 1st April 2012, me and my partner Becky lost our beautiful son, Tyler. He was only 15 months old when he passed away peacefully in his sleep. Later that year, we began fundraising for a brilliant charity, The Lullaby Trust (formerly known as FSID).
Sam Allardyce – The Sensible Choice? by realprojection
My view of Sam Allardyce is heavily influenced by the most exciting match I've ever watched. Ipswich's 5-3 (AET) defeat of Bolton in a play-off semi-final second leg in May 2000.
The National Conundrum by Bluetaff
No, not the referendum – although don't get me started on that can of worms, I mean the constant disappointment of the national team at… well, the national game.
What We Need for the Upcoming Season by itfccymru
With the lads back in pre-season training yesterday, I thought I'd write a short blog on what positions/players that could really improve us for the tough season ahead.
Confessions of a Statto - Why We Bother by ITFC_Forever
Hello, my name is ITFC_Forever, I am a bit (a lot) of a statto and have never written a blog before.
Ipswich Town Polls
[ Vote here ]


text:
Healthy Teamwork
Collaborating with our spouse in spiritual disciplines can strengthen our walk with Christ, as well as strengthen our marriage.
Recent Episode
The Charge of A Stepfather
Gil Stuart reflects on the vital role of a stepfather as he considers the man who raised Jesus. Listen to the full program here.Listen
Recent Episode
Sleep and Marriage
Like falling asleep, changes may not happen right away, but a healthy environment gives your relationship its best chance to flourish.Listen
Making Marriage a Priority in Your Blended Family
Intentional decisions you make to keep marriage a priority in your blended family.Read more
Resources to Help Your Marriage Thrive!
Choose from among a variety of relevant and engaging resources to help you in your marital journey. Yours today for a donation of any amount!Read more
Dealing With the Past When You're Remarried
Gil and Brenda Stuart brought memories, habits and history into their new marriage. They learned the importance of acknowledging the associated emotions and being able to talk about them.Read more
At Home With Kirk and Chelsea Cameron
In a culture where celebrity nuptials can often be counted in days or even hours, Kirk and Chelsea Cameron's marriage has thrived for more than 18 years.Read more
Have You Lost Hope in Your Marriage?
For Couples in Crisis ... You can still put the pieces back together with Hope RestoredRead more
Help to Strengthen Families
Please give to support family ministry. Your gift will go to work immediately — transforming lives through the power of the Gospel.Donate Now
It's Not About the Money
Frequently, financial conflicts focus on how each spouse handles money. But most arguments about money really grow out of a failure to understand each other's needs and to respect each other's personalities.Read more
Choosing to Love Your Husband
Do you feel overwhelmed trying to be the perfect wife in a perfect marriage? Join Jen Hatmaker in escaping impossible standards and fighting for grace.Read more
A Marriage Restored
One couple learned to restore the joy in their relationship with a visit to the National Institute ofMarriage.Read more


text:
The North Face Class V Short
6.6 oz / 188 g
129 g / sq m 100% Polyester
Where to Buy
sponsored links
Retailers' Descriptions
Here's what other sites are saying:
Navigate rough waters wearing The North Face Class V Short. These quick-drying nylon shorts are constructed with a comfortable elastic waistband with a belted closure for a secure fit.
- Mountain Gear
Summertime means living at the lake, endless lemonade, and The North Face Women's Class V Board Short. This itty bitty piece of peached polyester feels soft no matter how many straight days you've worn this short. The 4. 5-inch inseam doesn't leave much to the imagination while the elastic waistband gets a bit of back-up from an external drawcord, because you know all your girlfriends and their penchants for pantsing.
- Backcountry.com
The North Face Women's Class V Shorts are the ultimate amphibious short for all your adventures in the water and out. Soft, light and abrasion-resistant peached TNF Apex Stretch Fabric stands up to abuse, even if you're sliding down the rocks at your favorite swimming hole. DWR finish and quick drying fabric won't hold water once you're back on dry land. Protects from the sun's harmful rays (UPF 15). An internal drawcord fine-tunes fit. Mesh lined hand pockets drain quickly when coming out of the water. A small overlap mesh pocket inside the waistband secures keys or other small items even in white water. At the beach, in your favorite swimming hole or charging whitewater, this women's North Face Short will keep you comfortable. Material Abrasion resistant TNF Apex Stretch Fabric. Water resistant, quick drying fabric. Ultraviolet Protection Factor (UPF) 15. Elastic waist with internal drawcord. Mesh pockets with draiage holes. Security internal pocket. Average weight: 3.9 oz or 110 g. Average inseam: 5 in or 12.7 cm. Available Color(s): TNF Black
- Tahoe Mountain Sports
Take The North Face Women's Class V Shorts on your next river trip for the ultimate in comfort and protection. Quick drying and with a UPF of 50, this classic rafting short will shield you from the sun's harmful rays and from the water lapping over the side of your craft. Whether you're paddling through calm channels and inlets or taking on the rapids of unpredictable rivers, The North Face Class V Shorts for women have your back.
- Altrec Outdoors
On Sale. The North Face Women's Class V Short DECENT FEATURES of The North Face Women's Class V Short Improved Class V fabric is heavier, more durable and offers better sun protection Ultraviolet protection factor (UPF) 50 Quick-drying performance Full elastic waist with internal drawcord Internal security pocket Solid and printed patterns The SPECS Average Weight: 6.6 oz / 188 g Inseam: regular: 6in. Fabric: 129 g/m2 100% polyester This product can only be shipped within the United States. Please don't hate us.
- Moosejaw
The North Face Class V Short
currently retails for:


text:
Getting started
Our team has been putting together a couple of "getting started" videos for your convenience.
The license could not be verified: License Certificate has expired!
How to shares files with Razuna
How to work with widgets and embed content
How to manage users and groups
Feature Requests & Bugs
If you want to request a feature, found a bug or want to see our Road Map, please visit our dedicated – Feature Request & Bug platform
For USING Razuna
For Developers
Razuna Tools
For Administrators
Installing & Updating Razuna