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Now Playing / Re: Heavy music: turn it up to eleven!« on: August 31, 2013, 05:15:23 AM »
Only Heavy music Ive been into in recent years is Tool.......the videos below should come with some sort of warning. Makes Hellrasier seem like a kids cartoon IMHO. Kind of like the music better without the visual element. Thats just me.


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Fans of America's Coachella, which is held from 15-17 April in California, have compiled a tentative line-up on the festival's forums.
As reported by Spinner Music, users have suggested Interpol, Glassjaw, DJ Honda and Sasha through a collection of Twitter updates, interviews and tour dates.
The article says: "Most think that Arcade Fire are locked down to headline one night", and suggests that The Rolling Stones could top the bill on another.
80s icons Duran Duran, The Black Keys and Cults are rumoured to be joining them, as well as the Chemical Brothers, Sleigh Bells and Wire.
Other potential performers include Cold War Kids, The National, The Cribs, Crystal Castles and Foals.
Broken Social Scene, DeVotchka, Robyn, Titus Andronicus and Gogol Bordello also made it on to the fan-curated list.
No acts have been officially confirmed for the festival.
Tickets are available now at $269 for a weekend pass.
Click here to buy Coachella tickets.

subset: commoncrawl


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|David Weintraub <qazw...@gmail.com>
|Re: BUILD FAILED messages in output when using <Ant/> tasks
|Thu, 18 Jun 2009 13:19:43 GMT
The BUILD FAILED messages are not printed during the call to task "test2", but after "test2" exits due to an error. They are part of the output from Ant and not the task itself. If you want the BUILD FAILED output, you need to first capture the output of Ant and not of a single task. You also need to redirect STDERR into STDOUT since the "BUILD FAILED" message prints on STDERR. In Unix, you can do this: $ ant test1 2>&1 | tee ant.out In Windows, it's something like this: C:> ant test1 > ant.out 2>&1 Unlike Unix, this won't print the output on the console. Another possibility is to use the "try/catch" tasks in the AntContrib package. This allows you to "try" a task, and if it fails, do your own response. This way, you could append a "BUILD FAILED" message onto your log yourself. Another possibility is to capture the exit status of the Ant command and append the BUILD FAILED message to the log if the ant command returns a non-zero error. On Wed, Jun 17, 2009 at 7:02 PM, 5dark <firstname.lastname@example.com> wrote: > > Hey all. > I notice when using the <ant output="mylog.txt" .../> task if a exception > or > error occurs in the Ant project then the error doesn't show up in the <ant> > task's output file (in this example "mylog.txt"). > > EG: > > with ant code: > > <target name="test1"> > <ant dir="${basedir}" inheritAll="false" > target="test2" output="${basedir}\mylog.txt"> > <property name="myparam" value="what"/> > </ant> > </target> > > <target name="test2"> > <taskdef/> > </target> > > The output is (ignore the line numbers): > > test1: > test2: > > BUILD FAILED > C:\work\WS\build\build.xml:4580: The following error occurred while > executing this line: > C:\work\WS\build\build.xml:4586: Only antlib URIs can be located from the > URI alone,not the URI > > But the contents of mylog.txt is just: > > test2: > > > Is there anyway to make the error show up in the output file (mylog.txt)? > > Thanks! > -- > View this message in context: > http://www.nabble.com/BUILD-FAILED-messages-in-output-when-using-%3CAnt-%3E-tasks-tp24083705p24083705.html > Sent from the Ant - Users mailing list archive at Nabble.com. > > > --------------------------------------------------------------------- > To unsubscribe, e-mail: email@example.com > For additional commands, e-mail: email@example.com > > -- David Weintraub firstname.lastname@example.com
|View raw message


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The Philadelphia Jazz Orchestra, directed by Joe Bongiovi, will perform a benefit…
Summer Worship Hours
During the summer months, our worship time will change to 10:00am and our Sunday…
Weekly Update July 18 – July 24, 2016
THIS WEEK AT NEW COVENANT July 18 1:00 pm NA 5:30 pm TOPS July 19 1:00 pm NA…
Welcome Home!
PLEASE NOTE: During the summer months, our Sunday morning worship service will be held at 10:00am and our Sunday School program will be on summer vacation. We will return to regular hours (Sunday School 9:30am and worship 10:45am) on Sept. 11th.
We have been waiting for you! It's true, because we believe that every person who comes into the circle of this special fellowship was nudged to do so by God's Spirit.
It won't take you long to discover that this is truly a family, rich in the relationships that matter most. Growing together, we worship, we share, we laugh, we cry, we learn, and we reach out to our world with life-transforming truth. We reach out to you, as well. Our doors are open. Our hearts are open, too. If you have been thinking, praying, searching and hoping for a place to belong, we say: Welcome Home!


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|Message view
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|Dirk Bromberg <bromb...@tzi.de>
|Re: Font embedding FOP dev
|Wed, 28 Sep 2005 06:24:29 GMT
Ok, thanks. with file:///E:/mypath_to_font.... it works... btw: the path to the metrics can be setup as relative path to the "startup dir" but the "fontpath has to be absolute..." Dirk Manuel Mall wrote: > On Wed, 28 Sep 2005 05:07 am, Andreas L Delmelle wrote: > >> On Sep 27, 2005, at 22:27, Dirk Bromberg wrote: >> >>> i wants to test to switch my project from 20.5 to dev. >>> >>> Now i want to embedd my ttf fonts via the fop.xconf. >>> >> <snip /> >> >> >>> but i always get the exception "D:\mypath_to_run\ArialUNI.xml >>> FileNotFoundException" .... the Path is not relative to the xconf! >>> it is relative to my running directory. >>> >> Ouch! The user-configuration functionality is not fully ported yet, >> especially the baseURL bit... Sorry. The entry is present in >> fop.xconf, but currently serves no purpose. >> >> Since I do need to finish up a few things in that area of the code, >> most likely I'll be able to squeeze it in during the weekend. >> >> >>> How can i set the right directory? I've tried to set the >>> D:\mypath_to_run\confdir as basePath via the >>> fop.getUserAgent().setBaseURL(...) but there was no change... >>> >> The only way I see that might --note: not 100% sure-- temporarily >> solve your problem is to include the full pathnames in the >> font-triplet (possibly even as full 'file://' URLs to avoid them from >> being interpreted as a relative URLs) >> >> Why the baseURL isn't taken into account when building the font-list, >> I'm not certain, but this does mean that even if I complete the >> user-configurable baseURL, it still won't work as it did before... >> >> For now, try out with absolute URLs in the triplets. As far as I >> understand the related code, that should do the trick. >> >> > > This is a known problem with the trunk code (see > http://issues.apache.org/bugzilla/show_bug.cgi?id=36729). I had a look > at fixing it but it involves changes to the font subsystem. That area > of code is currently being completely rewritten (integration of a 3rd > party font system) and I would expect this to be fixed as part of that > work. However, this may not happen in a real hurry. > > For the time being you have to use absolute paths or to be more correct > full URLs in your font definition files, that is everything must start > with file:// as Andreas suggested and be fully qualified. > > >> If not, don't hesitate to report back. >> >> HTH! >> >> Cheers, >> >> Andreas >> >> > Manuel > > --------------------------------------------------------------------- > To unsubscribe, e-mail: email@example.com > For additional commands, e-mail: firstname.lastname@example.com > --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
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Friday marks the halfway point for the 2016 Missoula Osprey season. Today at noon Ryan Tootell of 102.9 ESPN Missoula will give us an update on how they are doing and what he's expecting to see in the second half.
And did you know the local sports talk show Ryan co-hosts won this year's EB Craney Award for sports broadcasting? The show is called Tootell & Tucker, and it's on every weekday 4-6 pm on 102.9 FM! ... See MoreSee Less
"I'm concerned for the boy's health and the general sanitation of this festival. Where are the comment cards located?!"
www.newyorker.com/culture/culture-desk/music-festivals-in-your-thirties ... See MoreSee Less
Music Festivals in Your Thirties - The New Yorker
Attending the Governors Ball this year, I realized that the rock, mud, and vomit is beginning to look a little different.
We have some great giveaways happening today for Win-it-Wednesday!
WIN tickets to these great events:
8-5-16 Bruce Hornsby & the Noisemakers at The Wilma
8-12-16 Amy Helm & the Handsome Strangers at The Top Hat
8-6-16 Tell Us Something at the Peas Farm ... See MoreSee Less
Trail 1033 updated their cover photo. ... See MoreSee Less


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- DimcoGray Part #1-262-002
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DimcoGray Black Phenolic Fluted Torque Knob Female, Brass Insert: 3/8-16" Thread x 5/8" Depth, 2-3/8" Diameter x 1-9/32" Height x 1-1/4" Hub Dia x 5/8' Hub Length (Pack of 10)
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Small Parts has teamed with DimcoGray, the industry leader in the design and manufacture of molded plastic knobs and handles, to provide the widest variety of components for virtually any application. DimcoGray's singular focus on the design and application of knobs and handles insures that you will have the right component for your fastening and control needs. DimcoGray's engineering group has designed knobs and handles that are can survive the toughest environments while still meeting the ergonomic needs for human-machine interface. That is why at DimcoGray we provide Solutions At Hand (R). Small Parts and DimcoGray, the winning combination for knobs and handles.
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Hotel Accommodation near Odeonsplatz
Search 18 hotels near Odeonsplatz
Last-minute Munich deals
- Fleming's Hotel München SchwabingfromNZ$144NZ$141
- Dorint Hotel Airport München FreisingfromNZ$157NZ$144
- Mandarin Oriental MünchenfromNZ$1,092
- Seehotel LeonifromNZ$196
- arcona LIVING MÜNCHENfromNZ$136
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Hotels within 0.5 kilometer of Odeonsplatz
- Most bookedHotel Vier Jahreszeiten Kempinski München
170 people looked at this hotel in the last hour
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"great location, close to shops, restaurants, and cultural activities"
A Traveller, May 2016, US
122 people looked at this hotel in the last hour
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"Pleasant. Just an overnight. It would be more courteous of the hotel to leave a free bottle of still water at night rather than trying to charge you EUR 8.95 for a bottle!"
A Traveller, Mar 2016, GB
65 people looked at this hotel in the last hour
Most recent review
"We are coming to Munich regularly 2-3 times a year last decade. My husband and me agree this is the best Munich hotel. It is like a secret pearl, situated in a historical, quiet neighborhood, with comfy rooms, very clean, quick enough elevators, helpful and nice staff, excellent breakfast, cozy l..."
P, Jun 2016, US
43 people looked at this hotel in the last hour
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"The room was small but well organized. The bathroom was very small but the shower was amazing. Excellent location. Excellent staff. They are so helpful and courteous."
A Traveller, May 2016, US
14 people looked at this hotel in the last hour
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"This hotel is in a very lively part of Munich near the Hofbrauhaus, Opera Theater, Englischer Gardens, and within walking distance of the art museums, Resident, and more. Metro is easy to navigate, hotel staff was very friendly and helpful, and the breakfast was very good. The room was small, but..."
A Traveller, Feb 2016, US
Hotels within 1 kilometer of Odeonsplatz
172 people looked at this hotel in the last hour
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"When we checked in there was a mix up in our reservation. They cleared it up and upgraded our room to a beautiful suite."
A Traveller, Oct 2015, US
122 people looked at this hotel in the last hour
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"LOVED this hotel. The hotel is modern, clean, amazing service with great attention to detail. The room was a little small but very comfortable. The location. Was excellent! Endless restaurant choices just outside the front door and less than 10 min walking to the metro to take you anywhere. Ma..."
A Traveller, May 2016, US
30 people looked at this hotel in the last hour
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"Staff was very helpful. Used their bike to ride around town and their workout facility. Easy access to great parts of Munich"
A Traveller, Jun 2016, US
27 people looked at this hotel in the last hour
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"Ended a four week trip here and felt very comfortable, real nice breakfast, excellent location, super mattress. Room was not overly fancy, just nice and quaint, especially after suffering the beds in the East where often even high end hotels will provide a bed fit only for an army barracks. We ..."
A Traveller, Jun 2016, US
- Hotel AntaresNo Guest Reviews yet
5 people looked at this hotel in the last hour
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Can someone please help me. I am new to this and am having some trouble. I hope this is where I am supposed to be. Here is what I am trying to do:
I am selling a product on my website and my customer has the option of choosing a certain background and a frame if they want one.
I have a page where they choose their background and that takes them to another page with the picture of their background and the option of adding a frame.
How can I get all of their selected options onto a new page that will show their order (i.e. the background they chose and the frame they want) and then a button where they can add their purchase to a shopping cart (i.e. paypal shopping cart) Any help will be greatly appreciated!
Thank you,


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Top Definition
To be "led down the primrose path" is an idiom suggesting that one is being deceived or led astray, often by a hypocrite
Don't let that girl lead you down the primrose path.
by FreakTower January 11, 2012
Trending Now
Emails are sent from firstname.lastname@example.com. We'll never spam you.×


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DiDio & Lee Say Early "Rebirth" Response is 'Uncharted Territory' for DC Comics
Comic Books
Showing results 1-40 of 712
A new tweet reveals the "Dredd" star's new haircut makes him look more like Marvel's Skurge the Executioner -- and Thor plays Connect Four?
At Comic-Con International: San Diego, Marvel Studios revealed logos for the slate of movies in Phase 3 of the Marvel Cinematic Universe.
"Thor: Ragnarok" props shown at Comic-Con International: San Diego reveal a connection to the "Planet Hulk" comics.
Following "Civil War" #3's example, CBR looks at ten other examples of hero-on-hero crime where the stakes were so high murder was the only option.
Jane Foster is a worthy Thor today, but was she once ruled "unworthy" to wield Mjolnir? CSBG explains that story and more forgotten comic book plots.
Axel Alonso shares insight on new Marvel NOW! series including the young heroes of "Champions" and "Invincible Iron Man," which puts Riri Williams inside the armor.
When Jason Aaron and Olivier Coipel debut "Unworthy Thor" in October, will you be adding the new Marvel series to your monthly comics list?
The disgraced god will once again headline an ongoing comic in a new series from long-running "Thor" writer Jason Aaron and returning artist Olivier Coipel.
Andy Park shares his concept art's evolution from the page to the screen, showcasing work from "Civil War," Guardians of the Galaxy" and more.
Years before she became the new Thor, Jane Foster shared a body with the Asgardian Sif. Whatever happened to that story? CSBG has the answers!
You don't need the power of the Norse gods, just some basic materials, a decent workshop and these step-by-step instructions.
Director Taika Waititi promises Chris Hemsworth comedy for "Thor: Ragnarok," "Wolverine 3" is casting cartel thugs, and more.
CSBG counts down the top five times that Marvel Comics Asgardian hero Thor has encountered Ragnarok -- and lived (or not) to tell the tale.
Using scientific principles, researchers have determined the "best-equipped superheroes." Apparently Batman's just lucky to be alive.
Josh Brolin praises the "Avengers: Infinity War" script; Mark Ruffalo teases Hulk action and heart in "Thor: Ragnarok" and more.
Director James Gunn clarifies that photo of himself holding Mjolnir was just that, and not a hint at a Chris Hemsworth cameo.
Director James Gunn posed for a picture with Thor's hammer Mjolnir while filming on the "GOTG2" set.
CSBG lets you know how to pronounce the name of Thor's hammer and other tricky comic book pronunciations, like Ka-Zar, Darkseid, Namor and more!
Perry hints at a return as a fan-favorite mutant for "TMNT 3," the CW releases a new "Flash" VFX featurette and more.
The strongest viking there ever was makes trouble in Marvel's "The Mighty Thor" #7 by Jason Aaron, Rafa Garres and Russell Dauterman.
CSBG answers reader-submitted questions, like the latest: Has Iron Man lifted Thor's hammer? If not, just who HAS over the years?
An ex-Marvel Studios exec opens up about the early days of the company, and where the IP could have gone.
CSBG answers a variety of reader-submitted questions, like their latest -- has the Incredible Hulk ever lifted Thor's hammer, Mjolnir?
Jason Aaron teams with artists Russell Dauterman and Rafa Garres for a special tale involving Loki in the present and Young Thor in the past.
Jimmy Kimmel will host a week-long Marvel celebration that will include Benedict Cumberbatch's unveiling of the "Doctor Strange" trailer.
Appearing on a Chicago TV station, the "Thor" star was quick to point fingers at Loki's "brother from another mother" for the impending stormfront.
Silk, Thor, Ms. Marvel, Captain Marvel, Sif and Spider-Gwen will keep you toasty AND safe with this Marvel fleece blanket.
It's Throwback Thorsday as Jason Aaron, Russell Dauterman and Rafa Garres deliver a tale of Marvel's young Thor in the age of Vikings.
According to data from the Scottish government, six babies born in that country last year were named Loki. However, there was just one Thor.
New characters are sometimes born of editorial mandates, and Ron Marz recounts writing a trio of Marvel Annuals designed to satisfy that desire.
Combining cosplay with home repair, one fan came up with the perfect idea for a replica of Mjolnir that opens to reveal a tool set.
In their latest spotlight on comic books showing up in outside media, CSBG looks at how "The Big Bang Theory" asked who could life Mjolnir.
Captain America is far from the first superhero to reclaim a role they previously left behind, and we look at some of the best.
"Super-Heroes Poop Lab" is one artist's imaginative look at the excrement of some of the world's most famous costumed characters. Relax, it's not gross.
Christmas is right around the corner, so take a page out of these comic books and deck some halls -- and maybe Santa, while you're at it!
"An Illustrated Guide to Iconic Fictional Locations" showcases memorable fictional settings, and assesses their features, flaws and, yes, their color palettes.
Mondo has released a hot new batch of Marvel posters for their ""Snikt. Bamf. Thwip: A Celebration of Marvel Comics" exhibit on December 11.
Screenwriter Stephany Folsom has been hired to work on the script for Marvel Studios' "Thor: Ragnarok," scheduled for release in 2017.
Remember the comic where Thor spoke to Captain America from beyond the grave -- even though Cap was still alive at the time?
Mark Ruffalo shares his thoughts on The Hulk joining Thor and Loki in "Thor: Ragnarok," instead of being featured in his own standalone film.
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If you need a Savior....
If you're looking for a way to connect with people who will accept you...
If you're searching for depth and meaning in your life...
If you're hungry to feel the goodness and grace of God...
If you sense the whisper of the Holy Spirit calling you to something more...
then Welcome home to First Church!
We dream of a church where all generations embrace each other, supporting the development of healthy families and healthy adults through teaching, relationships and worship, in order to build up the family of Christ where all are welcomed and all are loved.
If you have not yet found a church home, we invite you to worship with us.
What is the First United Methodist?
Who we are, what we believe and how we live out our faith...CLICK HERE
Vacation Bible School
Cave Quest!
Kids will participate in a hands-on mission project, through a project called Operation Kid-to-Kid, that will let kids in our community show God's mighty love to needy kids in the United States.
Plus, we'll help kids discover how to see evidence of God in everyday life - something we call God Sightings. Get ready to hear that phrase a lot!


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Lawyers in East Chicago, Indiana (IN)
Joseph Lawrence Curosh III
1532 119th St, Whiting, IN 46394
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4704 Indianapolis Blvd, East Chicago, IN 46312
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4525 Indianapolis Blvd, East Chicago, IN 46312
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|Home | About | Journals | Submit | Contact Us | Français
Traditional determinants proven to be of prognostic importance in breast cancer include the TNM staging, histological grade, proliferative activity, hormone receptor status and HER2 overexpression. One of the limitations of the histological grading scheme is that a high percentage of breast cancers are still classified as grade 2, a category with ambiguous clinical significance. The aim of this study was to best characterize tumors scored as grade 2.
We investigated traditional prognostic factors and a panel of tumor markers not used in routine diagnosis, such as NHERF1, VEGFR1, HIF-1α and TWIST1, in 187 primary invasive breast cancers by immunohistochemistry, stratifying patients into good and poor prognostic groups by the Nottingham Prognostic Index.
Grade 2 subgroup analysis showed that the PVI (p = 0.023) and the loss of membranous NHERF1 (p = 0.028) were adverse prognostic factors. Relevantly, 72% of grade 2 tumors were associated to PVI+/membranous NHERF1- expression phenotype, characterizing an adverse prognosis (p = 0.000). Multivariate logistic regression analysis in the whole series revealed poor prognosis correlated with PVI and MIB1 (p = 0.000 and p = 0.001, respectively). Furthermore, in the whole series of breast cancers we found cytoplasmic NHERF1 expression positively correlated to VEGFR1 (r = 0.382, p = 0.000), and in VEGFR1-overexpressing tumors the oncogenic receptor co-localized with NHERF1 at cytoplasmic level.
The PVI+/membranous NHERF1- expression phenotype identifies a category of grade 2 tumors with the worst prognosis, including patient subgroup with a family history of breast cancer. These observations support the idea of the PVI+/membranous NHERF1- expression immunophenotype as a useful marker, which could improve the accuracy of predicting clinical outcome in grade 2 tumors.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
An employee with cancer is likely to find support and encouragement at work. Another employee with an alcohol or substance addiction is more likely to try to keep the illness hidden because of stigma, even as medical professionals say both are … more
By Mary MacDonald | firstname.lastname@example.com | 9/25/15
PROVIDENCE – Twenty-six Real Jobs RI grant recipients were announced last week by Gov. Gina M. Raimondo. The workforce-training partnerships, available through the state Department of Labor and Training, span more than 10 sectors; … more
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|Publication number
|Publication type
|Publication date
|Oct 1, 1968
|Filing date
|Jun 2, 1964
|Priority date
|Jun 2, 1964
|Publication number
|Muncheryan Arthur M
|Original Assignee
|Arthur M. Muncheryan
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (1), Referenced by (25), Classifications (18)
|External Links: USPTO, USPTO Assignment, Espacenet
United States Patent O y 3,404,350 DIRECTED-BEAM PORTABLE LASER SYSTEM Arthur M. Muncheryan, 1735 Morningside St., Orange, Calif. 92667 Filed June 2, 1964, Ser. No. 371,994 7 Claims. (Cl. S31-94.5)
ABSTRACT 0F THE DISCLOSURE A directed-beam portable laser system is described w-hich comprises a pistol-configured housing with an aiming telescope. Internally, the housing compr-ises two main compartments: a forward compartment having a laser-beam generator and a beam-intensity amplifying means with an outlet section adapted to convert the laser radiation into a parallel beam at the beam emergence port; and, a rear compartment containing a rechargeable direct-current power supply connected, through a controlled vibrator mechanism and a step-up transformer, across the laserbeam generator means for activation thereof. A multipleswitch mechanism -imparts safety for triggering the laserbeam generator means. Lasercooling means and a temperature indicator are also provided in the system.
This invention rela-tes to laser generators and more particularly to a portable laser generator which produces a powerful beam of laser radiation whose intensity remains effective to distances of many miles.
The present .portable laser generator is a lightweight, compact, and high-intensity laser-radiation generator which receives its laser-activating energy from a highintensity electric discharge liashlamp energized by a self? contained electric power supply. The generator can be carried in hand from place to place easily and conveniently and can be used while being carried as Well as when stationary, since it has no electric connections or cables to any external power supply source. Because of a provision of a multiple-switch mechanism for triggering laser act-ion, away in a carrying case,'"if necessary, self-activation to laser action.
For its principal advantage, -th'e laser generator is provided with a solid-state laser emitter which receives a high-intensity radiation in the visible and near-visible spectral range, and converts it to a monochromatic and coherent laser radiation in the wavelength range of 6800 to 9000 angstroms.
An object of the invention, therefore, is to provide a self-contained D-C electric -power supply which can be recharged, after exhaustion, by connecting it to a 110- volt A-C power source, such as a household power outlet.
A further object of the invention is to provide a means of converting the self-contained D-C power in the laser generator into .a pulsating direct current for enabling the voltage of the D-C source to be stepped up by a transformer so that the discharge ashlamp can be energized to a high-intensity light radiation.
A still further object of the invention is the provision of a light-gathering optical means which concentrates the radiation from the ashlamp to a high-intensity light and transmits it to the laser-generating element for inciting it to laser generation.
Another object of the invention is to provide a means for intensifying the laser radiation by concentrating it to a pencil beam prior to emergence of the laser radiation from the portable generator.
Other objects and advantages of my invention will Ibe best understood from a consideration of the following specification taken in conjunction with the accompanying drawing forming part thereof, in which:
without fear of the generator is safe to handle or store.
FIGURE 1 is a detail-sectional view of the portable laser generator, showing constituent parts contained therein.
FIGURE 2 is a cross-sectional view of the portable laser generator taken at A-A, and
FIGURE 3 is a schematic diagram illustrating the arrangement of the rechargeable electric battery, alvariable potentiometer connected across the battery, a vibrator to convert the D-C power from the battery to a unidirecacross which a potentiometer 3 is connected to furnish a,
variable voltage from battery 2 to a" step-up transformer 4 through a vibrator 5, which converts the D-C voltage from the battery 2 into a unidirectional pulsating voltage. The
vibrator consists of a relay 6, a vibrating armature 7, and a spark-quenching capacitor 8. A Spring 9 maintains the vibrating armature contact 10 in closed position with relation to the voltage from potentiometer 3. The pulsating unid-irectional voltage from transformer 4 is applied through leads 10a and 10b across the flashlamp 11, which contains Xenon and mercury vapor and radiates with a brilliant ash with each pulsation from the transformer'4. Since the frequency of pulsations is high, 15 to 40 pulses per second, the light emitted from ashlamp 11 appears continuous.
The frequency of the pulsations can be varied by 'moving the slide Contact 12 of potentiometer 3; increasing the voltage of the potentiometer output (by clockwise turning the knob 13 tg which the slide contact 12 is attached) will increase the number of pulsations per second, and decreasing this voltage, by rotating the knob counterclockwise, will decrease the pulsation rate. The contact prongs 14 and 15 from the battery 2 are used to connect the battery to a 11G-volt alternating-current sourcefor. charging the battery when necessary; the current from the A-C source to battery 2 is made unidirectionalby means of the rectiers 16 and 17. An insulating cap (not shown in the drawing) may be placed over prongs 14 and 15 to protect the user from a possible electric shock during use of the laser generator.
The current from the power supply battery 2 to the flashla-rnp 11 can be traced as follows: To incite the llashlamp 11 to radiation, the lasersafety switch 18 and the trigger switch 19 must complished by rst pushing the knob 20 forward; this knob could be located on the forward grip 33, when desired. Then, the trigger switch button 21 is squeezed to close the trigger switch 19. The last operation energizes the potentiometer 3, whose output is fed through the primary winding 4a of transformer 4, the armature contact 10 of the vibrating armature 7, the relay coil 6, and back to the potentiometer winding through slide con- -tact 12. i
When the flashlamp 11 is energized, its high-intensity light radiates in all directions in chamber 22; the radiation strikes the mirror 23 which, inv turn, reects and con verges the light in a forward direction. The reflected light from the mirror 23 together with the direct light from the ilashlamp 11 becomeincident on a conical bundle of fiber optics 24, which is also known commercially as light pipe because of its property of transmitting light through its many tine filaments of glass of high refractivity. Because of the conical configuration of theber optics bundle 24, the light becomes concentrated at the cone be closed manually. This is ac apex 25, which area also represents the junction between the fiber optics bundle land a laser-generating element 26, forming a finite space therebetween which acts as a reflector of laser radiation. The laser-generating element, or simply laser element 26, maybe made of a cylindrical ruby rod, neodym-ium doped glass rod, or any other suitable laser-emitting material. The forward surface 27 of laser element 26 is thinly coated with a light-reflecting material, such as silver or a dielectric reecting material.
The reflective coating of surface 27 is necessary because in laser generation the emitted radiation .must oscillate axially in the laser rod in order to become amplified. The amplification is achieved by the cumulative collision of photons in the rod and their production of additional photons from it. Therefore, the emitted laser radiation oscillates by reflecting from the thinly coated surface 27 to junction 25 and back. This latter process continues until the radiation intensity of laser reaches a maximum threshold level, whereupon the laser beam bursts out through surface 27, passes through a second conical fiber optics bundle 28, and out to space from the cylindrical apex 29, integral therewith. In passing through the conical fiber optics bundle 28, the laser beam converges and thereby its radiant density Id increases in accordance with the equation Id=1r(D/2)2+1r(d/2)2=D2/d2, where D is the diameter of the base of the cone, and d is the diameter of the apex of the cone.4 For instance, if the diameter of the base ofr ber optics bundle 28 is 20 times the diameter of its apex 29, the laserlbeam emerging from the apex 29 will have an intensity 400 times greater than that produced by the lase-r element 26.
As the chamber 2,2 warms up, the heat due to ashlamp 11 therein is gradually'conducted through the fiberoptics bundle 24 to the laser element 26, whose normal operating temperature is between 70 and 85 F. when the latter temperature range is exceeded, the efficiency of laser emission decreases. To prevent excessive heating of the laser element 26, the surface of the housing 1 around. the heataffected zone is provided with fins 30, which radiate the heat tothe atmosphere and thus maintain a relatively low temperature, or normal laser emission temperature. A thermometer 31 is also provided in the wall of chamber 22 to monitor the temperature therein; this thermometer, when properly calibrated, may indicate the relative temperature of the laser element 26.
In operation, the laser generator is held by two hands, one holding the trigger grip 32 and the other the forwa-rd grip 33. The switch 18 is closed by pushing the knob 20 forward with the index nger of the hand holding the trigger grip 32. The generator then is aimed at the desired target by means' of the telescope 34, and then the trigger button 21 is squeezed. The generator immediately starts to tire with a pulsatingburst of laser radiation. To stop the laser action, the trigger 21 is released and the knob 20 is pulled backwards; this operation opens both of the switches 18 and 19. Any remaining charge on the condenser 8 becomes immediately discharged in the 'vibrator circuit. If the ibattery charge is weakened v subsequent to laser operation, the laser generator can be plugged into a llO-volt A-C power outlet and charged' within several hours.
Although a preferred embodiment of my invention is shown and described, the invention is susceptible to further :modificationin the detail of construction without departing from the spirit and scope thereof.
I claim:
1. A directed-beam portable laser system, comprising a housing of pistol configuration having a forward and a rear section, each section having a forward and a rear compartment respectively formed therein, and separated by a reflective partition therebetween; said forward secf tion tapering conically to a cylindrical projection integral therewith and having an aperture therein, and the rear compartment having therein a -rechargeable power supply; a forward and a rear hand grip integrally formed respectively on said forward and rear sections, for supporting said housing in an aiming position, with said rear hand grip containing a portion of said power supply; the compartment in said forward section having therein a laseribeam generator means with a conical light pipe attachedv thereto positioned anteriorly to said partition having its reliective surface facing said lightpipe; said laser-beam generator means being provided y'anteriorly thereto with a conical light pipe whose :base portion Ibeing in contact with said generator means and its apex having a cylindrical portion passing thrugh the aperture of said cylindrical projection of said forward section; said power ysupply being provided with a lowand a high-voltage 'section with said high-voltage section connected to said laser-beam generator means; series-connected dual switching means in the low-voltage circuit of saidr power supply and positioned in contiguous relation to said rear hand grip, whereby upon consecutive closing of said dual switching means said power supply transmits power through said high-voltage section to said laser-beam generator means to activate said means to emit radiation, which passes through said conical lite pipe and is amplified thereby by converging to a narrowfparallel beam defined by the diameter of said cylindrical portion at the apex of said conical light pipe prior .to emergence therefrom.
2. In a directed-beam portable laser system having a pistol-configured housing with an aperture at its forward end, a rechargeable power supply with a controlled vibrator connected in the circuit thereof and receiving direct cur-rent from said power supply to convert it into 'a unidirectional pulsating current, means in said housing and connected to the output of said vibrator for stepping up the voltage of said output, a laser generator means in the forward section of said housing and receiving voltage from said means for stepping up said voltage for activation of said laser generator means to emission of radiation, and an optical light conductor disposed adjacent to said laser generator means to receive laser radiation therefrom and to converge said radiation into a circular area anteriorly integral therewith prior to emergence of said radiation beam through the aperture of said housing, and a temperature indicator having its temperature sensing portion projecting into said housing .through the wall thereof and the indicator portion thereof being attached to said wall andprojecting to the exterior of said housing to monitor the temperature therein.
3. In a directed-beam portable laser system as defined in claim 1, wherein said laser-'beam generator means comprises an electric discharge tube and a laser rod with conical light conductors positioned at the opposite ends thereof; one of said conical light conductors having a frustum in contact with said laser rod and a base located adjacent said discharge tube and receiving light therefrom for converging said light on said laser rod for activation thereof; the second of said light pipes having its base contiguous with said laser rod and its apex terminating in a circular projection and receiving laser radiation from said laser rod for amplifying said radiation by converging it through the conical portion thereof to said circular projection, which converts said laser vradiation into a parallel ibeam prior to emergence thereof to the exterior of said system.
4. A directed-beam portable laser system as definedv in claim 1, wherein said housing having corrugations externally thereof for cooling the contents of said housingV other by a' partition with a lreflective surface facing anteriorly thereof, a gaseous discharge tube positioned adjacent to the reective surface of said partition and a laser rod with a conical fiber optics bundle at each end thereof to form a continuously tapering cone being disposed axially within said compartment and anteriorly to said discharge tube, with the base of said cone facing said discharge tube to receive therefrom illumination and to converge it through the conical section thereof onto the end of said Vlaser rod for activation thereof; the second of said conical ber optics Ibundle, having its lbase in contact with the front end of said laser rod and its apexV to convert the current thereof into a pulsating unidirectional current for amplification thereof by means of a transformer located in said compartment and connected to the output of said vibrator; the voltage output of said transformer being connected to said gaseous discharge tube to energize said tube to emission of light radiation. p
6. A directed-'beam portable laser system, comprising a housing having a forward and a rear section, forming a pistol configuration; each of said sections being pro- A vided with a compartment respectively disposed therein and separated one from the other by a reflective partition; the forward section of said housing tapering to an integrally formed cylindrical projection with an aperture disposed therein andthe rear section having a hand grip; a second hand grip secured to said housing in the forward relation of said rear hand grip to jointly stabilize said laser system in an aiming position aided by an ocular secured to the upper part of said housing; the compartment in said forward section being cylindrical and having therein a laser rod positioned in an axial relation to said compartment in the anterior aspect of said partition Whose reective surface being disposed oppositely to said laser rod, an electric discharge tube positioned anteriorly to said partition, and a conical fiber optics bundle disposed at each end of said laser rod; one of said conical fiber optics bundles being in intermediate relation between said laser rod and said partition andhaving a frusturnl which being in contact with said laser rod, and the second of said conical fiber optics :bundles having its base portion contiguous with the anterior end of said laser rod and its apex being provided with a cylindrical extension protruding through the aperture of the cylindrical projection of saidtapered forward section; the compartment in said rear section having therein a rechargeable power supply extending into said rear hand grip and connected therein to a variable-frequency power vibrator means 4coupled therein to the primary of an adjacently positioned stepup transformer whose secondary being connected across said` discharge tube for activation thereof; dual switching members connected in the circuit of said power s upply to turn on and off the current to said vibrator; one of said switching members being located in the wall of said housing externally thereto and the other switching member being secured externally to said rear hand grip, whereby upon simultaneous closing of said switching members, said vibrator receives current from said power supply, converts said current into a unidirectional pulsating current and applies it to said transformer to Ibe amplified thereby and applied to said discharge tube for emission of visible light therefrom, which light passing through said fiber optics bundle with frustum into said laser rod activates said rod to emission of laser radiation which, in turn, converges by passing through said conical ber optics bundle with a cylindrical extension thereon to be intensified by said fiber optics bundle prior to emergence through said cylindrical .extension thereof.
7. In a directed-beam laser system, an article of manulfacture comprising a conical housing having a. diverging base section, a sharply converging apex section with an aperture therein, and a cylindrical middle section` between said base and apex sections; a chamber of corresponding section coniigurations formed therein; al laser rod having parallel end surfaces secured within said middle cylindrical section of said housing; one of said surfaces having a fiber optics cone with a frustrum in contact with the end surface of said rod, the base of said cone being in register with the base periphery of said diverging base section and collecting Alight externally thereof to illuminate said laser rod for activation thereof to emit radiation; the second of said end surfaces of said laser rod being pro vided with a sharply converging fiber optics cone with the base thereof in contact with said laser rod and its apex terminating in a short cylindrical projection protruding through the aperture of the apex section of said housing, said last cone receiving radiation from said laser rod to amplify the intensity thereof by converging said radiation to said short cylindrical projection whereby said radiation is converted into a parallel beam prior to emergence therethrough; the combination of said housing and said laser rod therein`with its appended fiber optics cones at each end thereof forming a unitary device for generating a directed-beam laser radiation.
References Cited UNITED STATES PATENTS 3,304,403 2/1967 Harper S31- 94.5
OTHER REFERENCES J. Die Ment: Directed Energy Weapons,A Electronics i Industries (August 1962), pp. 92-96.
JEWEL'L H. PEDBRSEN, Primary Examiner.
W. L. SIKES, Assistant Examiner,
|Cited Patent
|Filing date
|Publication date
|Oct 14, 1963
|Feb 14, 1967
|Texas Instruments Inc
|Laser welding of contacts
|Citing Patent
|Filing date
|Publication date
|Aug 27, 1968
|May 25, 1971
|Gen Electric
|Face-pumped laser device with optical path folding
|Aug 12, 1969
|Feb 15, 1972
|Hutcheson Guilford J Jr
|Continuous wave laser surgical device
|Jun 16, 1971
|Jun 26, 1973
|Pioch W
|Visible line marker
|Jul 29, 1971
|Aug 14, 1973
|Siemens Ag
|Gas laser
|Sep 22, 1971
|Jan 22, 1974
|Muncheryan H
|Laser eraser for a typewriter
|Aug 18, 1977
|Dec 2, 1980
|Lemelson Jerome H
|Welding tool and method
|Jan 12, 1981
|Oct 5, 1982
|Cerberonics, Inc.
|Small arms laser training device
|Dec 30, 1983
|Aug 13, 1985
|International Business Machines Corporation
|Apparatus for thermo bonding surfaces
|May 28, 1982
|Mar 4, 1986
|Hitachi, Ltd.
|Surgical equipment
|Jan 30, 1984
|Oct 21, 1986
|Sutton A Gunilla
|Depilation device and method
|Mar 21, 1985
|Jun 30, 1987
|General Electric Company
|Apparatus and method for performing laser material processing through a fiber optic
|Oct 9, 1984
|Jul 21, 1987
|General Electric Company
|High power laser energy delivery system
|Jun 15, 1990
|Dec 24, 1991
|Schneider Richard T
|Medical laser device and method
|Feb 22, 2011
|Candela Corporation
|Methods for treating pigmentary and vascular abnormalities in a dermal region
|Aug 21, 2012
|Candela Corporation
|Treatment of skin by spatial modulation of thermal heating
|Oct 2, 2012
|Candela Corporation
|Method and apparatus for treating a diseased nail
|Nov 7, 2008
|Sep 17, 2013
|TRUMPF Laser -und Systemtechnik GmbH
|Laser processing machines
|Jul 19, 2011
|Dec 31, 2013
|Roy Larimer
|Stroboscopic illuminator
|Sep 28, 2006
|May 12, 2015
|Candela Corporation
|Method of treating cellulite
|Oct 31, 2003
|Jul 22, 2004
|Anderson R. Rox
|Method and apparatus for treating wrinkles in skin using radiation
|Jun 8, 2005
|Nov 17, 2005
|Anderson R R
|Method and apparatus for treating wrinkles in skin using radiation
|Nov 7, 2008
|Mar 19, 2009
|Trumpf Laser- Und Systemtechnik Gmbh
|Laser processing machines
|Mar 12, 2013
|Feb 12, 2015
|Zizala Lichtsysteme Gmbh
|Standard light source laser diode
|Nov 30, 1977
|May 31, 1979
|Eltro Gmbh
|Transversely excited atmospheric pressure amplifying gas laser - has discharge and cooling chambers separated by bus=bar serving as heat sink
|Jul 31, 1981
|Feb 17, 1983
|Siemens Ag
|Optical transmitter (laser)
|U.S. Classification
|372/72, 372/34, 372/29.2, 219/121.78, 219/121.73, 219/121.83, 219/121.61, 219/121.6
|International Classification
|Cooperative Classification
|European Classification


text:
The gallery reopens on August 18 with an exhibition by Matts Leiderstam. More information to follow. We wish you a great summer and welcome back in August!
The gallery reopens on August 18 with an exhibition by Matts Leiderstam. More information to follow. We wish you a great summer and welcome back in August!
Siobhán Hapaska at Andréhn-Schiptjenko May 12 – June 23, 2016 Andréhn-Schiptjenko is proud to present Siobhán Hapaska's second solo exhibition at the gallery. The opening takes place on Thursday May 12 between 5-8 pm and the exhibition runs through June 23. Hapaska has over the past two decades created original and formally complex work difficult (Read more…)
Mother of Pearl and followers Carin Ellberg at Kristianstads konsthall, June 11 – September 18, 2016 A multifaceted art practice in constant motion. Carin Ellberg is working on the boundary between painting, drawing and sculptural object. Her way of working is an ongoing process in which the conscious and indistinct flows in and out of (Read more…)
First Seen from the Lentz Collection First Seen (2008) by Matts Leiderstam June 9–August 6, 2016 In Conversation: Matts Leiderstam and Wilfried Lentz June 9, 2016, 6.30–8PM The event will be held in English. In First Seen (2008), Matts Leiderstam departs from a tropical scenery photograph, taken during United States Navy's expedition in Panama in (Read more…)
James Goldstein has donated his landmark residence in Los Angeles to the Los Angeles County Museum (LACMA). The donation includes a sculpture by Xavier Veilhan portraying the building's architect John Lautner.


text:
Street Triple & Street Triple R '12
Street Triple & Street Triple R '12
SW-MOTECH Universal GPS Mount Kit | Medium Navi bagThe SW-MOTECH Universal GPS Kit allows for a variety of installation options without additional accessories, and includes a medium splash-proof NAVi bag to protect your GPS from the elements. Learn More$83.95
SW-MOTECH Vibration-Damped Quick Release GPS Holder Kawasaki '06-'08 & Triumph Street Triple '12-'16The quick release function is ideal for the daily rider who needs to grab his electronics and go. This bike-specific electronics mount will hold any RAM-B-238-compatible RAM Mount, Garmin Zumo GPS, TomTom Rider GPS or a Bags-Connection GPS or PDA pocket. Learn More$83.95


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Don't listen to these pump and dumpers trying to tell you to buy this stock so that they can sell at a higher price at your exspense, didn't you see what happened this morning. Get out now and put your money in a stock with a more positive earnings reports such as Ebay(EBAY).
Reasonable statement about the P/E of dotcoms or the incredible runup, if they had earnings at all. I am sure a lot of people (including you) wished that startups in the biotech/pharma saw that kind of "appreciation".
It was easier for some to run up those stocks: no overhead costs, pay in stock options and not salary/benefits, just need an office space and a computer, and bingo - Pets.com.
Most understand that this industry takes a little while, and it involves serious costs.
So if you look at the business model here, showing some revenue from contract work is a very rational plan. It slows down the burn rate, and helps inexperienced personnel gain experience.
If ARRY announces something entering clinicals, and if the announcement indicates a significant portion of future revenue moves into the company coffers, then one might expect a runup of some significance, after which point a split might make people happy. The vested or near vested insiders want it very badly, and this carrot should make the pain of the stick less painful.
Over time stock will track as the clinical goes. Using partnerships for clinicals does spread the cost risk, but it dilutes the potential earnings. Spreading the risk would be advisable, so partnering would make sense. This approach is seen here, and it seems to be a rational and attractive longer term approach. However, if the reward is a few million in milestone payments, then I'm not sure about the effort.
Appointing a legal cousel is intriguing news for sure and positive. It appears this person will be on site, and not paid by contract. His degree choice is logical - burned out of chemistry with a masters, and went to law school. The early nineties recession also sent a lot of Ph.D.'s to law school as well, and they work as IP attorneys doing very well. He'll command a hefty salary, but the options will be pretty good, and any early exit plan will probably give him full vesting.
Nonetheless, you have a lawyer with some appreciation of chemistry, and whether other lawyers say this makes no difference, I beg to differ. He should speak the language of chemistry and biology well, and communicate effectively with the scientists and businessmen at Array.
To me, this is a very encouraging announcement, or at least it was designed to be.
Look at how many start ups there are.....very
similiar to the dot.com bubble. The shakeout will be ugly and chemists will be analyzing the chemical reaction of hot boiling oil and frozen raw potatoes.
Mark my message and check back in a year or so.
I don't see pharma stocks being viewed with "irrational exuberance" like the dotcom and telecom stocks. If that were the case, ARRY would be at $165 like WFII was.
This whole industry is like the dot.com bubble.
When it goes bust, Chemists will be working at
Thanks Synthon for your poignant reply
You recall that the demand for software folks was high a couple of years back during the dot.com boom. Startups require bodies, and startups need bodies for their IPO's to hold up or even be created. Funding is still moving into biotech area to create companies - lots of startups means lots of redundancy in personnell - just like the tech or dot.com boom. The redundancy is short lived, and employees have a false sense of security. Funding creates huge amounts of cash for venture capitalists who take companies public, then get OUT.
There are a lot of venture capital firms out there, and they can't pull it off with dot.com swindles.
Talk to your pizza delivery boy or "mortgage specialist" and you may find he was making 6 figures with huge options just last year.
One would like to be in on the start of this boom, and not the crest. On the one hand, profitable pharma companies are streamlining, and on the other hand, high risk ventures are booming. The risk is being spread out to the investor - you and me.
This industry will shake out within 2-4 years, provided it still gets some income from pharma in the meantime.
Recall the "electronics" boom of the 1960's - this was high tech. Same result as always - lots of swindlers and dreamers, and an eventual shakeout. There will be a handful of players who survive, and some who will be bought for a winning lottery ticket only to be dismantled. Most will fail, and most do fail.
How about the recent telecom boom? OUCH.
Biotech pure plays need hands to get molecules built, because they cannot afford to buy them - chemists are cheaper. The capital outlays are huge, and they have to go public even before they have shown promise. All dot.coms and techies needed was a plug and a computer. Used to be venture capitalists wanted to see some cashflow before an IPO - not anymore.
You are astute.
If you look at the money pharma invests in sales and marketing and compare it to R&D you will find that it is their view, not mine.
That said, there are many offerings for each disease class by many companies - how does a patient choose. Most of them are knockoffs anyway. Used to be, he did not, but the doctor did - perks are great for M.D.'s and health care providers. Now comes direct marketing to the consumer - why?. Perhaps health care providers are happy with what they have in the formularies - proven drugs, low liability, lower cost, and great efficacy.
One solution: Don't try to compete in all markets - Lilly is known for Prosac class drugs, diabetes, but you don't see their name on cardio. Mergers are defined by eliminating competition along classes of drugs - merge with your direct competitor in cardio, or your direct competitor in diabetes - sell of the other divisions or fire them.
This isn't working well, although the industry is poised for more mergers - remember that Euoropean companies have been the buyers lately.
FDA testing is stringent in relative terms, the clinicals are highly structured, only monitored and not run by the FDA. The FDA does not have the resources. Serious side effects not specifically looked for usually come out after a few years - look up phen-fen, or check into Tylenol and its effect. Right now, liver and kidney damage is an issue. If you use a drug, you might consider using one which has been on the market for years. That is exactly what hospitals do - they do not want too many suprises. No one has beat Synthroid for thyroid, and this one is as common as aspirin, and still on the top selling lists by usage.
Pharma tried joint ventures such as DuPont Merck to toss costs off on partners - this failed. Pharma tried using fine chemicals companies for making clinical trial quantities and intermediate quantities with the promise that fine chem would get the profits when the drug hit the market - fine chemicals bought this ploy, and are on the skids in debt.
Finally, startups and contract research is on the table. If big pharma is seriously looking at the value of Ph.D.'s and R&D (they are), and outsourcing R&D to startups to save money (they are), what gives. They don't want them as their own employees. Well, this time the partners and chemical companies have wised up, so why not try to get something from investors. So just get contract reseach done for pennies on the dollar, and lose nothing when a startup folds.
This time, the investor foots the bill.
The real value is in the clinical trial and those willing to participate. Most drugs are "me too" or very similar in structure - issues with kidney or liver toxicity are pretty well known from previous analogues.
Those who study and understand disease states and subsequently put chemists to work are of real value as well.
Without chemists, and their molecules, we would have nothing. The issue is in placing value (cost v. return) on sales/marketing, clinical trials, molecular biologists, M.D.'s in a relative sense.
As for pharma, think of a world without drugs. Some are of real value, and some are quite questionable in value. Long term investment in reputable companies can pay off, you get a dividend, and you don't have to watch the stock daily.
Explain the long list of want ads in Biotech listings in the San Diego Paper looking for Chemists?
You paint a very bleak picture. I am assuming you think industry is headed for a fall?
So in your view, it is better to hire highly skilled sales reps than Phds in chemistry?
If you are truly accurate, I feel sorry for anyone taking any drugs for anything. Hell, it is all a sales ploy.
Doesn't the FDA mandate testing to make sure the efficacy of the drug is legit?
One thing I can say that I am against are all of the ads on pharma drugs we see on TV now.
If we didn;t have any research scientists that are skilled, we would never have any chance at curing many diseases that plague us.
12) Corporations are investing large amounts in lawyers - for agressive patent protection, or finding loopholes in other patents. Seems to be a better course than using R&D.
13) Increase use of foreign imports w/o U.S. citizenship for Ph.D. grad schools - law of supply and demand - no supply in U.S. for the grant machine U.S. universities now run.
14) Increase in collaboration with universities by chemical and pharma - cheaper, and an admission that its better than hiring Ph.D's - just use university kids. This trend should scare you if you have this degree.
15) Increase in licensing university patents - again cannot get it done in industry, or too costly.
16) The argument has been made that process chemists may be in demand - one has to mass produce the drugs. This argument has not panned out. As well the fine-chem work is increasingly being exported to China and India. This is certainly a risk/reward decision.
17) European enviro regulations have been hard on employment there, sending euros here to accept lower wages. Definitely dime a dozen over there.
18) Wage spike driven by biotech/pharma startups is over.
19) Supply/demand curve for Ph.D's with synthetic experience has been somewhat inflated due to all of the startup ventures formed - they need some bodies and advertisement. Recall the dot.com bubble - its in the cards for Ph.D.s in chem soon. You need bodies to form an IPO, and investors are increasingly wary of IPO's
20) Double whammy - new pharma mergers, and failure of startups near term - market glut of employees.
21) Most 5 year plus degrees, plus a traditional post doc give don't give much return on the investment. Why is someone willing to do this?
22) Post docs are the norm nowadays, no jobs available, so post doc - too many Ph.D.'s or they are just so worthless to industry that they must hang out in school even longer - often for many years.
23) In an effort to prop up the degree value, post doc positions are increasing at the top 5 schools. Although you did not go to Harvard, you hung out for a one-year postdoc, and people assume you know something. The one year trend is mere an oversupply of Ph.D.'s and a marketing attempt.
24) Engineers just get paid more, and have more opportunity in their future careers. Most Ph.D.s sit at the bench inhaling fumes for most of their lives.
25) In an effort to keep jobs, jobs are created by startup ventures by the very people who find themselves out of a job.
Hope that helps.
If you have any suggestions about potential companies to track in Research Triangle Park, let me know.
1) Industry unemployment rate - always higher than national norm by 2-3% or more.
2) Number of degree granting institutions, and number of degrees granted.
3) Talk to recruiters or visit recruiter sites to find which jobs are hard to find people for resumes - no problem with chemistry/pharma. Lots of rotation in the sector, few long term employees.
4) The chemical sector is declining as a whole - witness the dissappearance of major chemical companies.
5) THe pharmaceutical sector is declining.
6) The pharmaceutical sector went through one round of mega mergers a couple of years back, and is now poised for another - this means "synergy" and more people on the street by elimination of duplication. Perhaps this is what spawned the startups - hence the Research Triangle park density.
7) Salaries are highly variable within the sectors requiring Ph.D.'s.
8) Pharma has relied on massive sales/marketing campains - less emphasis on actual efficacy of drug.
9) New trends of TV direct marketing amid worries of patents running out, no pipeline.
10) Given 8, and 9 above, one wonders exactly what Ph.D.'s are worth nowadays - they seem to be less efficient at getting a drug to market.
11) Given 10 above, one wonders about the value of the degree - it seems to be harder to get out a new drug, taking longer, and more problems with side effects. Don't blame the FDA.


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Proposes a hardware/software co-simulation environment using an RTL (register transfer level) simulator with a software language interface. The proposed simulation environment introduces the "operating system interface" (OSIF), which invokes system calls in the OS on the simulation platform to execute application software. The OSIF consists of data adaption facility and function correspondence management allowing it to cooperate with the OS of the simulation platform. We show the results of experiments with an R3000-compatible processor model. This environment verified our processor model with SPEC benchmarks that require various OS services. For example, with the Lisp interpreter program li, our detailed RTL description for the core part of R3000 was simulated only within 20 hours on a 109 MIPS workstation


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Teri Heyer's Reviews > Widow's Tale
Widow's Tale
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by Maureen A. Miller (Goodreads Author)
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May 24, 2012
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I thoroughly enjoyed reading "Widow's Tale." I was instantly drawn into the story and found the characters really came alive. Actually, I had to remind myself from time to time that they weren't real people. Honest, I don't usually get that drawn into a story. I don't want to give anything away, so won't go into the story itself, just let it be known that this is a romantic suspense worth reading. It's one you won't want to put down until you reach the very end. Now I'm looking forward to reading the rest of Maureen A. Miller's books.
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No expense was spared, upscale bed, desk, private entrance internet,wifi. You will have such a great nights sleep. A housekeeper comes 100 hours a month. No expense was spared for your comfort. You are treated so very good here. Go to the website and read all the testimonials, many more pics there. Here is a testimonial from the website and there are many more:
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Presents a heuristic model that can be used to estimate the dynamics of the wire array implosion. A two-shell precursor model has been developed. Expressions for the maximum precursor current and the precursor kinetic energy have been obtained. It is suggested that the difference in the resistance of the core and the corona of an individual wire is the reason for the precursor appearance. The precursor current increases sharply as the current rise time is lengthened. The most efficient way to suppress the precursor is to reduce the resistance of the core


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35 reviews | 4.6 out of 5
This is my favorite. I have been using exercise videos for about fifteen years. I have scores of them, including all of the most popular ones. This is the best. No equipment needed. It took me more than a week to do some of the routines to my satisfaction, so I did not complete the whole thing in eight weeks, but that does not matter. It does not initially seem to be as cardio-based as many others, but you will find that you are breathing heavily. After completing this, I went back and tried some of my older videos that had given me trouble. They were suddenly much easier. As for those who only gave this one star, one person did so after owning it for one week. I wonder if he tried to use all of the routines. Another said that it was too difficult. Well, it is difficult, but they show you modifications. You can also make your own. For instance, do the 90-second exercises for 45 seconds and slowly increase. As I said earlier, you don't have to finish each dvd in one week. You'll get there.
I finished the Weider 8-week program and am very happy with the results. I am very near my goal weight so losing weight at this point is difficult, but with this program I lost a total of 8 pounds and 4.6 total inches. I'm pretty happy overall as my tummy is much flatter now, my biceps have sprouted, and my back fat is gone! I followed the workout calendar to the best of my ability (I missed a couple days) and followed a reduced calorie diet pretty closely (again, I splurged on a few days). The instructor is very encouraging and I liked his training style. I never got bored with the workouts since they change every week. They do get harder as you go along, but you always have a model modifying the workout and showing you how to bring it down a couple notches if you need it. This series has made me get out of my cardio only funk and fall in love with strengthening workouts! I highly recommend them, and how could you go wrong with this price (in store it was $29)? Stop thinking about it and buy it! You won't regret it!
I started this in 1/2013. I was a bit skeptical at first...
I have completed the full 8 weeks, which I followed exactly (with the cardio every other day...and the diet). My main purpose was to tone. And although I do not have "the body I want in 8 weeks" I have noticable muscle definition in my abs, back, arms and legs -a HUGE accompishment!! I have even had folks notice a difference in me...and I have lost 1-2 pant sizes. The workout itself is challenging, but they do show a modified version for the workouts. The warm up and cool down are the same, but that does not bother me. The fact that you have a new DVD each week keeps you motivated and not bored. When I started this series, I modified a lot at first, then as I went on, I could tell that I did not modify as much. I am on the 2nd time through the series (I loved doing it that much)....what a difference, the only thing that I have to modify is the push-up, but I will get there. It is still an awesome workout the 2nd time around! I will probaly go through it again...until there is no modifying anything!!
I am a mom of 3 boys ready to get fit. I have seen the infomercials of P90x and Insanity and believe they can work but did not want to spend the money. Also, I felt that if the other workouts were too tough they would be intimidating and I would quit. This X-Factor set was a great price and just what I needed to get started...my heart rate increased, I was in the comfort of my home, took it at my own pace, felt the muscles working, and it was not difficult. They also show a person doing modified versions of the workout to make it easier. The only gripe I have about it is having to pause the dvd...certainly not a major reason, just have the remote handy. I figure any exercise program is better than not exercising and since the others are too expensive this one works for me! Maybe when I get more fit I will invest in the others but for now getting back in shape is my goal and this is a great starting point!
I have completed week one of this workout program and have pros and cons. I like the 30 minute workout and a five minute warm up and cool down. The workout progresses in intensity as you work out and that is nice as well. You get a good full body workout and the trainer is pleasant and encouraging. No equipment is needed although push up stands are provided for increased intensity. I like the level of workout it provides for me. Not as insane as insanity. I am working my way up to insanity in the future. At this time I am not the iron man or picture of health. Lol. To get there you have to start somewhere and this is a good place to begin. Areas to improve this product would be to provide a hard copy of the nutrition guide and workout schedule. It is provided on cd though. Biggest area to improve would be it needs to add a timer on screen for working out. I like how P90x has the minutes and seconds on screen for you. Music sound quality is sufficient but lacking in sound volume and quality. I like a beat to encourage my steps. I definitely recommend it still. Hope this helps you make your decision.
I am mid 40s and at least 30lbs over my target weight. I am on my third week and I am loving it. When I first previewed the video, I was intimidated by the intensity of the workout, but they show a modified version of each of the exercises so you have an option if you are having a hard time keeping up, but you will find yourself not needing the modified version sooner than you think. It gets tough but if you keep moving you will be able to do it all soon enough. I also love the idea that you don't need ellaborate equipment. After a few workouts, I did buy an exercise pad to workout on because you spend alot of time on the floor and I did find that a bit rough on knees and elbows because of the carpet I work out on.
I can't wait to see the results I will get by the end of the program because if I feel this much better in three weeks, the end result should be fantastic.
My family decided to improve our physique. I am about 30 pounds overweight. My husband is 40 pounds heavier. Our youngest plays h.s. football and in peak condition while his brother is just average. We could all do this program - I have to follow the modified at times. I was worried that it would stress my knee too much - I was unable to do complete P90x due to a history of a torn acl,mcl, tendon damage and lack of cartilage related to college ball. I am in week 3, 9 pounds lighter and a size smaller. My husband is 14 pounds lighter. This is practical, 30 min every other day. Cardio exercises on off days if you choose (I do, hubby doesn't). Kids find it very easy. Highly recommend. Can't beat the price. Need padding or cushion for a few exercises. Definitely try before spending mega $$. Haven't used the nutritional guide. Yoga stretches are great as well. Good luck!
I actually like this program better than P90X. Why? Because there is no required equipment. You're using your own body weight. Plus, the exercises and movements (some might call them "old school") are mostly medium impact but have options to make them low impact without sacrificing results. From my very first workout, I could "feel" it. It's almost prescriptive. At the end of the workout I knew where I was strong and where I was weak. But I won't be weak for long! You have to try this workout. I decided not to preview the rest of the workouts, but to come to each week for a fresh new start. I feel like I have a personal trainer right beside me through every drop of sweat. This is awesome!
I wanted to do P90x but knew if I bought it I would struggle so much the first few weeks that I would quit. Plus I don't have 90 mins a day to work out. This is 35 mins from start to end. It's a very good work out, fast paced and is actually fun to do. It's hard enough that you are wore out when you're finished and feel like you accomplished something. It's also not to overwhelming where I feel like I would rather just be fat that have to work out again.
Preface: About Me:29 year old male, Height 5'7'', weight at start 189LBs. About to start week 4, current weight 175lbs, my fitness level is above average. This product is great; a massive time saver compared to going to the gym. It gives you the option to play the workout without music so you can listen to your own, which i recommend. No equipment required, but i would buy or find a workout mat to lie on for ab work. The nutrition guide provided is on a CD, which is fine because the item would cost a lot more if it was a paperback. I've noticed the workouts become a little more difficult as the weeks progress. This workout plan can be as tough or as easy as you desire it to be. Bottom line, I'd reccomend it to anyone looking to be more physically fit. I've lost 14lbs in 4 weeks by doing nothing but eating right and working out for 30 minutes every. other day
I have tried other fitness DVD sets and was very disappointed in them, but this one well exceeded my expectations. For the price you really can't beat it. It comes with a full nutrition plan that even has grocery lists included and unlike books that you can only write in once, this set is all in PDF format so you can print and re-print all you want. I really like the exercises. The way the workout is set up it keeps you interested and moving plus its a little over 30 minutes so it's easy to fit into your schedule. The workouts are challenging but not so difficult that you never want to do them again. The best part is you don't need any equipment. All you need is a dvd player and your set!
Not gonna lie I got this thinking it would be a waste of $30 but needed something to keep me active when I can't go the the gym. Since I already work out on a pretty regular basis I wasn't excepting much but after the first day I was both impressed and sore! I just finished my first week and I have to say I got a better work out then I could have though possible from a set of $30 fitness DVDs. I love the fact that the lead guy is making it chessy but fun and that even at their fitness level they seem to be getting a good workout as well. I would Recommend these DVDs and even after the 8 weeks I plan on using them to supplement the stuff I do in the gym. The only Con I see with them is the same with ANY fitness DVD you have to apply yourself and push yourself otherwise it's not worth your money. So if you cant self motivate to pop the disc in a gym would be better
My husband and I decided that we wanted to lose some weight and as we were shopping one day, we impulsively bought this DVD set. I can't tell you how much we have loved that decision ever since. We only work out every other day and you really get what you put into it, but you will definitely get a workout even with the modified version. It really isn't that expensive, especially compared to other home workout DVDs. So far, we're on week 4 and I am already noticing increased strength in my core, as well as my clothes fitting looser. My hubby has noticed a difference in the definition of his abs as well as his pants fitting looser as well. Overall, we are very satisfied and would definitely suggest this to anyone looking for something that they can do in the comfort of their own home.
I am in week 3 now. And let me tell you.... I can already tell a change. Mainly in my arms, calves, and glutes. I am aiming for my abdominal area and it really hasn't hit that area as hard as I want it to although there is a dvd directlcy for the abs. Hopefully by week 8 I will see a bigger change and better experience. But overall... this is most awesome and most motivational and hope all those who purchase it keep with it because you WILL see changes. TRUST ME
I don't know what the other people that gave this a bad review were talking about. Yes, it can be high intensity and harder for someone that hasn't worked out in a while. But, there are modifications that they show you so that you can work up to their level. I just did my first workout and man it's just as good as if I had gone to a trainer! I definitely feel like I'm getting my money's worth.
Love this program. Was concidering the p90x but the price was a bit high. Bought X-Factor and lost 31 lbs in about 3 months. Really didnt do the food portion of it. Just watched what I ate, smaller portions, healthier stuff. The work out is great. Great motivation. Ab workout is killer. Yoga has some great stretching moves. The Body Blast workout disc is intense. Rapid fire exercises. If your on a budget, looking to lose weight and get in shape, get it!!!!!! Love it.
I enjoy working out at home & find following along with DVD more motivating. I like that no WTs are required, I like that it is only about 35 mins. I am pleased with the beginner modifications in the DVD. I can't do deep knee bends but partial bends don't seem to hurt my knees at all. The frog jumps--a do very lightly, and very small jumps--I still feel like I am getting a good workout by the end even though taking it at a light pace. I personally love the yoga/stretch DVD. I do it nearly everyday, does wonders for my achy back and various joint aches.
Vid 1, circuit 1: plank, table top, t squat, abs, supermans, sumo squat, circuit 2:abs, pushups, air jabs, ab twist, scuba diver, frog jumps repeat cir 1&2.
I picked this up after finishing an eight week cycle of Rushfit and was pleasantly surprised at how good it is.
I am on week 3 of the x-factor: ST workouts and the workouts rock! I love the interval training, body weight usage and there is usually a lower intensity to keep you moving at your own pace. A couple things I've noticed though, the warm up and cool downs are the same from week to week. I'd like more variety. I thought I'd be getting a paper back version of the nutrition guide and meal tracker, however they are given to you on a dic. Makes it a little inconvenient for those of us who struggle to keep on track as is. I feel myself getting stronger every week. Each week I start doing more lower intensity moves and by the end, I get up to the high intensity. But each week the workouts they perscribe are the same. Although the workouts make me sweat and I know I'm getting a great workout, mentally I'd like more change ups.
I am 49 now and literally almost 100 lbs overweight - i.e. 100 lbs over the light side of adult weight leaving high school and military service, even after my third child I had in my early 30's. I would not recommend this for everyone in my situation as it is difficult given my current size (the warm up wore me out the first time through!) ... but I do recommend the product as an excellent value and a very solid exercise program. There are exercises I need to modify the modified version, there are others I can do the exercise as is or do the modified well and at, or close to, the pace of the dvd. Sometimes I take an extra 30 seconds on the water break, I do not go back right away if I am breathing heavy. If something feels like it is pulling, I back off and modify or take a few seconds to re-group. Usually, I am not greatly sore, but a little bit in chest and legs. I have not lost a lot of weight, and not yet changed my diet, but am improving and pleased with the workouts. If I had a suggestion to improve the product it would be leave out the push up bars and print the nutrition guide/journal instead. Having those in hand would be helpful. Still I give it 5 stars all the way around for value, enjoyability and would recommend it to others looking for a home based workout program.