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Cancer Health Center
Endometrial Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - Description of Evidence
Interventions Associated With Decreased Risk
Oral contraceptives
Use of combination oral contraceptives (COC) for at least 1 year reduces endometrial cancer risk by approximately 40%, as demonstrated by case-control studies and prospective cohort studies.[8,9,10] This decrease in risk persists for at least 15 years after discontinuation of COCs. A meta-analysis of ten case-control studies and one prospective study found an association between risk reduction and duration of use. Overall, 4 years of COC use was associated with a risk reduction of approximately 56%; 8 years, 67%; and 12 years, 72%. The single-prospective study did not show a duration response, but the risk was reduced by 80% after 9 years of follow-up.[11]
A Swedish population-based case-control study confirms these findings. Women who used any type of oral contraceptive had a 30% risk reduction (odds ratio [OR] = 0.7; 95% CI, 0.5-0.9) and women who used progestin-only pills had a 60% risk reduction (OR = 0.4; 95% CI, 0.2-1.4). Women who used COCs for at least 3 years had a 50% risk reduction (OR = 0.5; 95% CI, 0.3-0.7) and those who used COCs for at least 10 years had an 80% risk reduction (OR = 0.2; 95% CI, 0.1-0.4). Overall, risk decreased by 10% per year of COC use and was observed for atypical hyperplasias as well as all grades of invasive tumors.[12]
Several cohort [13,14] and case-control [15,16,17,18,19,20,21,22,23] studies of physical activity and endometrial cancer reveal a weak to moderate inverse relationship, despite varying methods of assessing physical activity levels. For postmenopausal women enrolled in The Netherlands Cohort Study on Diet and Cancer, a 46% reduction (RR = 0.54; 95% CI, 0.34-0.85; P = .002) in risk of endometrial cancer was reported in those women who were physically active 90 minutes or more per day compared with less than 30 minutes each day.[24] One case-control study of 822 endometrial cancer cases and 1,111 population controls showed that regular exercise was associated with a 38% decrease in risk (OR = 0.62; 95% CI, 0.51-0.76) without a trend for increasing duration or intensity of physical activity.[25] The Breast Cancer Detection Project Follow-up Study, using a prospective cohort, did not confirm an association between recent physical activity levels and risk.[26] It is unknown whether physical activity reduces endometrial cancer risk by reducing obesity, by reducing serum estrone levels, or by another mechanism.[27]
Endometrial Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] Topics
Today on WebMD
WebMD Special Sections
- Talking With Your Doctor About Your Colorectal Cancer
- Treatments for Multiple Myeloma
- Mycosis Fungoides: A Rare Type of Skin Lymphoma
- Your Guide to Renal Cell Carcinoma
- CML Therapy: How to Stick to Your Treatment Plan
- The Facts About Common Cancers
- Facing Chemotherapy? Here's What You Need to Know
- Hodgkin Lymphoma: Treatment Choices for Refractory or Relapsed Disease
- How to Talk With Your Healthcare Team About Chronic Lymphocytic Leukemia
- Living With Multiple Myeloma
- What Is Paroxysmal Nocturnal Hemoglobinuria (PNH)?
- Cancer Prevention and Treatment


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Andrea Nunn
Revolving Door
Who's coming and who's going. Tell us about your job move! Receive the Revolving Door Newsletter with expert analysis by email twice a week.
November 23, 2011: Andrea Nunn has been named vice president of media and business development at Los Angeles Times Media Group. She had been vice president of domestic network distribution at HBO. (FishbowlLA)

subset: commoncrawl


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Smoking Cessation Health Center
Features Related to Smoking Cessation
Smoking: Drop the Habit Without Picking Up Weight
Quitting smoking and weight gain have long been linked. But when you kick the butts, is it inevitable yours will expand? True, four out of five people who smoke gain some weight. On average, people who quit gain between 4-10 pounds. Most weight tends to be gained in the first six months after quittiRead Full Article
S. Epatha Merkerson Crusades Against Smoking
The devastating effects of lung cancer are never too far from S. Epatha Merkerson's heart and mind. Two of her closest friends died from the disease. And in "nothing short of a miracle," a sister beat the grim statistics -- roughly 85% die within five years -- after a scare in the 1990s. A former smRead Full Article
The First 30 Days: Quit Smoking!
By Nicole Yorio 5 ways to get started. Choose a date to stop smoking, giving yourself enough time to create a plan and to elicit advice from other people who've quit. Then, write in a journal how often you smoke and under what circumstances — once you're aware of your triggers, you can come up withRead Full Article
Breaking the Habit
Almost 70% of adult smokers say they want to quit; the most common reason given is concern about their health. The concern is well justified. The four leading causes of death in the U.S. -- cardiovascular disease, stroke, cancer, and lung disease -- are all strongly linked to cigarette smoke exposurRead Full Article
Smoking Cessation Benefits
Q: How long after I quit smoking will I begin to see the benefits? A: Almost immediately. Here's a quick rundown from the Cleveland Clinic: After 20 minutes: Your blood pressure and pulse decrease. The temperature of your hands and feet increases. After eight hours: The carbon monoxide level in yourRead Full Article
How to Quit Smoking Like a Man
I started smoking when I was a bored and lonely 17-year-old irrigating alfalfa fields in Utah for money and reading Zen and the Art of Motorcycle Maintenance for enlightenment. I smoked watching magpies splash in the ditch, and for 20 years I kept sucking those nasty things for reasons of self-loathRead Full Article
Quit Smoking Without Gaining Weight
If you're a smoker, the healthiest resolution you can make is to kick the habit. But kicking butts often goes hand in hand with weight gain. Is it possible to be both slimmer and smoke-free in the New Year? It can be done, experts say -- if you go about it the right way. First, consider this: AlthouRead Full Article
Alternatives for Giving Up Cigarettes
Each year, millions of people vow to finally kick the cigarette habit, only to watch their optimistic expectations go up in smoke. But if they've tried and failed with conventional smoking cessation approaches -- whether it's the use of nicotine gum, counseling, or behavior modification -- they ofteRead Full Article
10 Overlooked Reasons to Quit Smoking
You know smoking causes lung cancer, emphysema, and heart disease, but you're still lighting up. To help you get on the wagon, we've compiled a list of little known ways your life can go up in smoke if you don't kick the habit. From an increased risk of blindness to a faster decline in mental functiRead Full Article
Can You Get Away With Social Smoking?
Lots of people say they're just social smokers. Odds are, they're fooling themselves. You've seen them at parties and in bars. They usually bum smokes from more serious cigarette addicts. Their excuse: They aren't really smokers -- they're just social smokers. Is there really such a thing? The surprRead Full Article


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All stories by Andrii
Ukraine, Estonia, Chile, Finland: The saga of four accelerators
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Dublin's attracting more tech events and startups from abroad than ever before
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What's in between traditional work and the gig economy
Jobbaticals show how new innovation hubs can appear in the most unexpected places.
The future of media monetization: Cryptocurrencies and micropayments
Monetization of content projects, be it a newspaper or online-only news publication, is a pain these days. When we saw massive ...
Tech news in Eastern Europe: December
Even though December is a traditionally slow month for tech news, it has brought quite a number of stories worth your attention ...
FeelSpace uses vibrating motors to help the blind feel the right direction
The Germany-based team of FeelSpace has developed a vibro belt for outdoor navigation, which can significantly improve the ...
Catch up with tech news from Eastern Europe: November
Check out our round-up of the most important tech news headlines from Central and Eastern Europe.
The pros and cons of investing in emerging startup ecosystems
Emerging markets have been a hot topic (or a buzzword) among VC funds and angel investors alike over the last few years. ...
Tech news from Eastern Europe: October
Another month, another dose of tech news and feature stories from Central and Eastern Europe. We've carefully selected a ...
This AI powered shopping list app reminds you to buy stuff if you forget
The idea of using your mobile phone instead of countless pieces of paper to hold grocery lists has been around since the ...
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While virtual reality has been seen as the future of technology for the last few decades, there aren't too many truly innovative ...
Enter sugar snake: Hands-on with MEL Science's next-gen chemistry kit
There's a new, potentially disruptive, player in the chemistry set market: the Russian-British startup MEL Science.


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Steph Lova
WPGC/Washington D.C. Bringing Steph Lova In To Join Joe Clair Morning Show
CBS RADIO Top 40/Rhythmic WPGC/WASHINGTON D.C. is bringing in STEPH LOVA to join the JOE CLAIR MORNING SHOW. STEPH LOVA will team with host JOE CLAIR and News Dir. GUY LAMBERT beginning MONDAY, AUGUST 15th. STEPH LOVA started her radio career at ... more »
KXJM (Jam'n 107.5)/Portland Announces Boo Bomb 3
iHEARTMEDIA Top 40/Rhythmic KXJM (JAM'N 107.5)/PORTLAND has announced its 3RD ANNUAL JAM'N 107.5'S BOO BOMB throwback concert. The SATURDAY, OCTOBER 15 show at ... more »


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Humbucker Pickups
- Best Sellers
- On Sale
- Price Drop
- Open Box Gear
- Top Rated
Results 1 - 40 of 295 matches
Top RatedSeymour Duncan APH-2s Alnico II Pro Slash Humbucker...
A warm, moderate-output humbucker pickup set designed to produce Slash's unique recorded guitar tone.$209.00Compare Compare Now site1prod712624
- 1 Open Box:
- $194.37
Price DropSeymour Duncan SH-1 1959 Model Electric Guitar Pickup
It looks and sounds just like a '59, warm and smooth with great sustain.Starting at $72.00Compare Compare Now site1prod300010
- 3 Open Box:
- $73.47
Top RatedSeymour Duncan Hot Rodded Humbucker Set
The neck SH-2 Jazz and bridge SH-4 create strong definition with bold, dense tone that's ideal for any heavy...$145.00Compare Compare Now site1prod300030
Top RatedDiMarzio DP100 Super Distortion Pickup
4-conductor versatility with coil-splitting capability. Regular or F-spacing.
Starting at $79.99Compare Compare Now site1prod302000
- 2 Open Box:
- $74.39
Top RatedSeymour Duncan Vintage Blues '59 Humbucker Set
Based on the vintage P.A.F. humbuckers of the late '50s "perfect for blues, jazz, and classic rock.$145.00Compare Compare Now site1prod300022
Top RatedGibson '57 Classic Humbucker Neck Pickup
The '57 Classic features Gibson's special Alnico II magnet; vintage enamel-coated wire; nickel plated pole...Starting at $139.99Compare Compare Now site1prod306000
- 1 Open Box:
- $134.99
Top RatedSeymour Duncan SH-4 JB Humbucker Pickup
The world's most popular humbucker guitar pickup.Starting at $75.95Compare Compare Now site1prod300035
- 1 Open Box:
- $73.47
Price DropStarting at $199.00Compare Compare Now site1prodJ24658
Top RatedStarting at $99.00Compare Compare Now site1prodJ01567
Top RatedGibson '57 Classic Plus Pickup
The perfect bridge-position companion to the '57 Classic. The '57 Classic Plus mimics those late-1950s...Starting at $149.99Compare Compare Now site1prod306012
Top RatedDiMarzio Steve Vai Evolution Humbucker Set
Designed with live gigs in mind, but make great recording pickups too.$214.99Compare Compare Now site1prodH70685
Best Seller$269.00Compare Compare Now site1prodJ24666
Top RatedSeymour Duncan SH-PG1 Pearly Gates Pickup
Pearly Gates(TM): Essentially a variation on the Patent Applied For sound, the Pearly Gates sound is sweet,...Starting at $96.95Compare Compare Now site1prod301100
Top RatedSeymour Duncan SH-2N Jazz Model Pickup
For players seeking an accurate, clear tone for lightning-fast jazz runs. Its brighter sound with slightly...$79.00Compare Compare Now site1prod300060
Top RatedDiMarzio DP193 Air Norton Pickup
Fat and warm, yet not muddy. It's hot, but not distorted. It's even got cool harmonics. The patent-applied-for...Starting at $69.99Compare Compare Now site1prod302704
- 1 Open Box:
- $84.62
Top RatedEMG ZW Zakk Wylde 81/85 Humbucker Set
Professional upgrade pickups.
The 81 has high output for razor-sharp attack and is best for high-volume...$199.00Compare Compare Now site1prod301511
Top RatedEMG EMG-81 Humbucking Active Guitar Pickup
Exceptional for high-gain rock leads with high output, consistent distortion, and long sustain.$99.00Compare Compare Now site1prod301504
Top RatedSeymour Duncan SH-6 Distortion Humbucker Pickup
Tremendous power and raw distorted rock sounds.Starting at $75.95Compare Compare Now site1prod300042
Price DropSeymour Duncan SH-8 Invader Pickup
Powerful, energetic output with unique brightness.Starting at $79.95Compare Compare Now site1prod300070
Top RatedDiMarzio DP155 Tone Zone Humbucker Pickup
The Tone Zone has the most dramatic tone curve of the Modern Classic Humbuckers. The vowel-like open wah-wah...Starting at $79.99Compare Compare Now site1prod302430
Top Rated$239.00Compare Compare Now site1prodJ15329
- 1 Open Box:
- $222.27
Top RatedSeymour Duncan SH-5 Duncan Custom Guitar Pickup
A beefed up Patent Applied for tone.Starting at $75.95Compare Compare Now site1prod300040
- 2 Open Box:
- $73.47
Top Rated$79.00Compare Compare Now site1prodJ11176
- 1 Open Box:
- $73.47
Top RatedDiMarzio DP151 PAF Pro Pickup
Slices through heavy processing, where darker-sounding pickups get lost in the mud of the effects chain. Low...Starting at $79.99Compare Compare Now site1prod302040
- 1 Open Box:
- $74.39
Top RatedDiMarzio DP102 X2N Pickup
It's DiMarzio's highest gain pickup, designed to push tube amps into total overdrive. Twin wide-bar pole...Starting at $80.96Compare Compare Now site1prod302021
Top RatedDiMarzio DP104 Super 2 Humbucker Pickup
Super Distortion sound with brighter top and lighter bottom.$69.99Compare Compare Now site1prodH72288
Best SellerFernandes Sustainer FSK-101 Humbucker Pickup Kit
Includes Sustainer pickup, system PC board, wiring, connectors, pot, and all necessary hardware.$249.00Compare Compare Now site1prod300421
Best Seller$189.00Compare Compare Now site1prodJ24663
Best SellerStarting at $209.00Compare Compare Now site1prodH94768
Top RatedEVH Frankenstein Humbucker
Wound to the exact specs as the original Frankenstein's pickup, this humbucker is a the perfect upgrade for...$159.99Compare Compare Now site1prod580302
- 1 Open Box:
- $148.79
Top RatedSeymour Duncan Blackouts AHB-1 Humbucker Set
Blackout hum, crank up the tone. 9V powered neck and bridge humbuckers provide more extended frequency...$199.00Compare Compare Now site1prod301007
Top Rated$164.99Compare Compare Now site1prodH70682
- 1 Open Box:
- $153.44
Top RatedDiMarzio PAF DP103 Humbucker 36th Anniversary Guitar Pickup
Have you ever wondered what a Fifties humbucker sounded like when it was new, before the magnet weakened and...Starting at $74.99Compare Compare Now site1prod302712
- 1 Open Box:
- $69.74
Best Seller$219.00Compare Compare Now site1prodJ24667
- 1 Open Box:
- $203.67
Top RatedGibson 498T Alnico Humbucker
Increased midrange with extra high-end crunch along with vintage warmth and sustain. The 498T can deliver a...Starting at $109.99Compare Compare Now site1prod306060
- 1 Open Box:
- $104.99
Best Seller$189.00Compare Compare Now site1prodJ24673
- 1 Open Box:
- $175.77
Best SellerSeymour Duncan Antiquity II Adjustable Mini-Humbucker
Vintage craftsmanship, mini-size, huge tone.$145.00Compare Compare Now site1prodH68340
- 1 Open Box:
- $134.85
Best Seller$169.00Compare Compare Now site1prodJ24665
Top RatedSeymour Duncan SHPR-1s P-Rails - Neck and Bridge Pickup Set
A humbucker pickup set that splits to either a full-size P-90s or a special Alnico-powered single-coil Rail...$195.00Compare Compare Now site1prod583280
- 1 Open Box:
- $181.35
Best Seller$199.00Compare Compare Now site1prodJ13293
For electric guitarists who prefer a fat, round tone with zero hum, the humbucker reigns supreme - in fact, it's been that way ever since it was created by Seth Lover of Gibson in 1955. Today's line of humbuckers is a lot more extensive than it was 50 years ago, and this catalog has more than enough options to prove it. From Gibson '57 Classic Humbuckers to Seymour Duncan Hot Rodded Sets and even EMG signature models from Zakk Wylde, you've just hit the mother lode when it comes to humbucker pickups.
If you're new to the guitar, you might be wondering what the difference is between humbuckers and single-coil. Before the humbucker was developed, there were only single-coil pickups, (essentially, magnetics) which contained wire that was wrapped around a series of magnetic poles. No matter which company manufactured single-coil pickups, they all faced the same issue: unwanted frequencies and hums. The creation of the humbucker solved this dilemma; by pairing two pickups together, they cancelled each other out and the hum was eliminated (ie: bucked). Another upside to the humbucker's design was that they produced more output, which is why so many guitarists who favor a heavily distorted sound use them. Of course, every guitarist has their preferences when it comes to pickups: some only use single-coils or humbuckers exclusively, while others prefer their axe to have both single-coils and humbuckers (which can be combined for creating any number of cool guitar tones).
To better understand which humbucker pickups are right for you, you'll need to know how each humbucker design will influence your guitar sound. In this section, you'll find both active and passive pickups. If you're a metal guitarist, your best bet is to go with an active pickup because they have a higher output. Need some suggestions? Try the EMG-KFK Kerry King 81/85 Humbucker Set or Seymour Duncan Livewire Dave Mustaine Active Pickup Set.
While active pickups deliver a very balanced sound no matter how soft or hard you play, passive pickups respond to your playing technique. If you want a more versatile sound and play a variety of genres like jazz, blues or early rock, passive pickups are for you. There are many best-selling passive pickup options here, including the DiMarzio DP155 Tone Zone Humbucker Pickup and the Gibson 498T Alnico Humbucker, amongst others.
There are so many humbucker pickups that deserve a closer look, you'll definitely want to spend time here. Swiping out your current pickups for a set of new humbuckers is an excellent way to upgrade your axe and get the tone you've always dreamed of. Just remember that when you're ready to make the change, practically every humbucker pickup you can imagine is waiting in these pages.


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|2 Reviews
|Property type
|Minimum Stay
|7 nights
Location! Location! Location!
Spectacular waterviews from large fenced in yard. Enjoy the beautiful sunsets at the end of the day.3 houses away from Little Bay and across the street from Great Bay. Perfect for kayaking, swimming, shelling, fishing and walking. Short stroll to the Ocean beach (Nantucket Sound). Close to historic downtown, shopping, restaurants, and ferry to Martha's Vineyard. Bike to Woods Hole. Play Golf, Watch future major league baseball stars play in the Cape Cod League. Go whale watching, Shopping at Mashpee Commons. Drive or take scenic bike ride to Woods Hole to enjoy aquarium, fishing from pier, restaurants and shops. Able to walk to grocery store, Walmart, movie theater, Christmas Shoppe and many other stores. Easy access to Rte 28 if you want to explore the rest of the Cape.
This house is uniquely situated that you can walk or bike to everything you want to do in Falmouth.
We thoroughly enjoyed every minute of our vacation at Maravista. The house was very spacious and clean. The owners are great and very prompt in responding to inquiries. While on vacation my daughter had to register online for her university courses and the owner made sure that she had no problems with the internet, which we really appreciated. The ferry to Martha's Vineyard was just a 5 minute ride by car. Our kids enjoyed playing in the huge backyard. Awesome fishing and excellent beach which is just 10 minutes walking and 5 minutes by car. Definitely recommend this property and we hope to return someday. Also, received my security deposit on time.
We just spent a week at this house with 7 children from the ages of 6 to 18. I can't say enough about it. We had an incredible time. The house is very clean, the rooms are very spacious, the big backyard is great for kids to play and for BBQs. The grounds are very well kept. And what amazed me the most with how well stocked the house was with everything we needed all week. The location is phenominal, 10 minute walk to the beach - 2 minutes by car. 5 minute car ride to a shopping center with a WalMart, TJ Maxx and Shaws (although we preferred the Shop & Save 2 minutes futher). The kids would have been happy to stay on Maravista all week but we did take a few day trips to the big mall in Hyannis and to Provincetown and the 28 that took us there was just 5 minutes down the road. And the icing on the cake was GREAT communication with the owner, who went out of her way to make us comfortable and was very helpful in so many ways. We took many memories and pictures with us and all 9 of us would return in a heartbeat.
This house is uniquely situated on highly sought after Maravista. Spectacular views of Little Pond can be enjoyed from back patio. Great Pond is across the street and Nantucket Sound is an easy stroll. Swimming, kayaking, shelling, fishing and boating can all be enjoyed within walking distance. Perfect location for scenic walks, biking, shopping (historic downtown Falmouth and Mashpee commons), restaurants, Martha's Vineyard Ferry, Woods Hole, golfing, movie theater, Cape Cod baseball league (see future major league players), antiquing and whale watching.
Other Activities: kayaking, clamming, bseball league
Golf: Many challenging courses within easy driving distance (10-20 minutes)
|Rate Period
|Weekend Night
off peak - fall
Sep 3 2016 - Oct 1 2016
7 night minimum stay
My Standard Rate
7 night minimum stay
$600 nonrefundable deposit
$1,250 off peak, $1,850 peak.
$1,250 off peak, $1,850 peak
By check


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Hotels in Maidens, United Kingdom
Search & Compare Maidens Hotels
Trending now in Maidens
Hotels in Maidens
- Most bookedMalin Court Hotel
9 people looked at this hotel in the last hour
Most recent review
"One night stay in Ayshire to fit in sight seeing and a trip to Culzean Castle."
A Traveller, Aug 2015, GB
Hotels within 5 miles of Maidens
27 people looked at this hotel in the last hour
Most recent review
"Another fabulous stay Turnberry has everything lovely hotel beautiful scenery great breakfast."
A Traveller, Sep 2015, GB
- Blanefield HouseNo Guest Reviews yet
4 people looked at this hotel in the last hour
Hotels within 10 miles of Maidens
14 people looked at this hotel in the last hour
Most recent review
"From the moment I arrived, the staff looked after everything. They went above and beyond the call of duty even using their own cars to drop me off at the hotel I was attending a wedding. I thoroughly recommend this great place"
M, Jun 2016, GB
7 people looked at this hotel in the last hour
Most recent review
"Really friendly staff. Very helpful. Rooms are clean and comfortable."
A Traveller, May 2016, GB
Hotels within 15 miles of Maidens
21 people looked at this hotel in the last hour
Most recent review
"I booked the hotel based on the reviews and was not disappointed. The staff were welcoming and helpful. The room was a little tired with no view but adequate for the price. Location was good with easy access to the esplanade and walking distance to the town. Breakfast was very good and included i..."
A Traveller, Aug 2015, GB
15 people looked at this hotel in the last hour
Most recent review
"We stayed here as we were attending a wedding at the Brig O Doon. Stayed 2 nights. It is an easy walk into Ayr from the hotel. It has a lovely garden in which to advantage of the recent good weather. Our bedroom was lovely and situated to the back so very quiet. We had a lovely meal on the first ..."
A Traveller, Jun 2016, GB
12 people looked at this hotel in the last hour
Most recent review
"we really enjoyed our stay. The owners were pleasant ,and helpful. We travelled for 3weeks and stayed at lot of B&BS. This was one of our favourites, and the best breakfast of all! The rooms were spotless and there were extra added touches. I would recommend this place to anyon."
A Traveller, Oct 2014, CA
8 people looked at this hotel in the last hour
Most recent review
"From welcome to farewell staff friendly helpful but unobtrusive. Room comfort and facilities excellent. Food very good and plentiful - would highly recommend the 2 for 1 meal deal. Very handy for shore and town."
A Traveller, May 2016, GB
8 people looked at this hotel in the last hour
Most recent review
"lovely stay in this hotel. Family friendly clean and welcoming. Lovely cooked breakfast really enjoyed my stay and would go back again"
A Traveller, Jun 2015, GB
Best hotels in Maidens
If you are looking for Maidens hotels in a particular area, you can use the search feature at the top of the page to search by neighborhood, landmark, address or zip code, or you can search by using the built-in map feature. You can also browse hotels in Maidens by type, amenities, and star-rating so that you can find the best hotel. Currently, top rated hotels in Maidens are:
- Malin Court Hotel
- Sunnyside Bed and Breakfast
- Grange View
- Trump Turnberry, a Luxury Collection Resort, Scotland
- Carrick Lodge Hotel
The location of your Maidens hotel is important. If you are traveling to Maidens, &StateorCountry for business, you may want to consider getting a hotel close to the airport or near your meeting venue. By doing so, you can really cut down on transportation costs and time. You may also want to book a hotel that offers free wifi just in case you need to get some work done.
If you are traveling for vacation, figure out which attractions or landmarks you want to see and book a hotel that is within close proximity. Although hotels near attractions might cost a little more, you may find that spending those extra few dollars is worth the convenience. You can even find hotels that align with your interests. For example, if you are looking for a relaxing vacation, a spa hotel may be the perfect choice for you.
You'll also want to determine which type of accommodations will suit your needs before booking a hotel in Maidens. If you're traveling with the kiddos, a family friendly hotel will offer larger rooms and more sleeping arrangements. For those traveling for an extended period of time, booking a hotel suite with a kitchenette is a smart move and will feel a little more like home. If you are budget conscience and just need a place to rest your head, a hostel or motel may be all you need.
If you are looking to score the best discounts and deals, use the filter to sort by price from low to high. You can book a hotel in Maidens for as low as $86 per night. If you are looking to cut down on expenses, look for hotels that include free breakfast and parking. Some hotels even offer free shuttle service to and from nearby places. You can also sort by star rating, proximity, and guest rating.
Before you book, check out user reviews. Hotels.com has 36 reviews in Maidens. We show reviews from Expedia and TripAdvisor so you know that you are reading genuine, reliable reviews. Be sure to download the Hotels.com app so you can book your reservations on the go, view amenities, and save the hotels you want to view and compare later.


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Platinum Delta Card
American Express®
American Express®
Some logos are just more mature than others. And with this Mega Monogram Bundle, you'll be able to show your clients that you truly mean business! This Mighty Deal includes 55 carefully crafted vintage logo templates with monogram incorporated for that extra all-business look. They're highly customizable, plus this set includes a bonus 100 vector elements to work into your designs.
Download it here: http://bit.ly/55logos
Stroke Logo Templates by
Victor Barac
This pack includes 32 unique logo templates. Very easy to modify and use, perfect for creating logos, labels, badges, apparel, typography, websites, banners, stamps, stickers, t-shirts, etc.
Download it here: http://crtv.mk/b0DvL
Evolution of Aaliyah Dana Haughton. ♥
June cereal packaging. Www.danielgwells.com
Animals Made From Circles
12•0 | 16/100
sorry for being inactive and damn i am 3987423874 days behind with this productivity challenge but then i dont usually take photos. so today im dedicating it to my logotype portfolio project uwu this weeks gonna be hella intense
UYENGOC . / Vietnam
The Van is a comfortable, inviting coffee shop/restaurant based in
Hanoi, Vietnam. Designed to make the customers to feel like home, in
the company of family and friends.
Desmond Wong
Steps Collection by Yoga Perdana
Wask New Free Font by forgraphic™
Follow us on Instagram @graphicdesignblg


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{GIVEAWAY} Win a $50 Gift Certificate from Via Blossom
If you haven't checked out Via Blossom yet, you are in for a treat! Via Blossom sell all the best party decor (glass milk bottles, flowered paper lanterns, pretty cake stands, petite blossom cups... just to name a few of my favorite things)!
I'm excited to announce that one of our lucky readers will receive a $50 gift certificate to their shop. I could seriously go crazy with that!


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The Hit List
August 13, 2015
Weekly Feature
Thanks to BooBooNinja for today's question!
What's the Best Setting Powder that you've tried?
Share your pick! And don't forget to share why!
I love Guerlain's Les Voilettes and Urban Decay Naked Loose! They both blur pores and keep makeup on well.
-- Christine


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The White House - Napa Valley Inn
Summer Savings SpecialAvailable dates:
10% off midweek stays (Sunday-Wednesday) through the end of July.
Our downtown Napa boutique hotel has a fresh new look following a complete renovation. To celebrate our grand reopening we're offering a great midweek deal... from now through July 31 guests can get 10% off any midweek stay (Sunday-Wednesday).
Holidays (May 29-30 and July 3-4) and Napa festivals (July 17-21) excluded. Subject to availability and minimum night requirements. Not valid with any other offer. New reservations only. Must book directly with the hotel. The SUMMER promo code will auto-populate when you click through this page – simply mention the Summer Savings Special when booking by phone.


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In the red: Jemma Kidd's make-up empire goes into administration
She has enjoyed a successful career as a model and make-up artist but, when it comes to business, Jemma Kidd has found life can be a little tricky.
Jemma, 38, who is married to the Duke of Wellington's grandson, the Earl of Mornington, has been forced to put her celebrity make-up company into administration after it ran up debts of more than £2 million.
At the same time she has been personally fielding complaints from disgruntled customers who have taken to Twitter to air their grievances after failing to contact her through the company's customer care line.
Bust: Former model Jemma Kidd's beauty brand is now in administration
The mother of two set up Jemma Kidd Make-Up Ltd seven years ago with close friend Grace Fodor, the star of the BBC business programme Be Your Own Boss.
Jemma quickly became the face of a line of cosmetics stocked in shops including Harvey Nichols, Boots and Space NK. Sales initially gathered pace and the business appeared to be thriving.
But in 2008 the first signs of financial strain began to show. After losing money when Jemma's range of lipsticks, eye-shadows and foundations was discontinued at Boots, and with surplus stock past its sell-by date in warehouses, they reached crisis point.
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Staff were put on a four-day week while Jemma — sister of supermodel Jodie Kidd and great-granddaughter of the late newspaper baron Lord Beaverbrook — opted to work only three days a week. Then, late last week the business was put into administration and its 30 staff made redundant.
Customers, however, turned to social networking websites to track down their orders.
One, businesswoman Linda Grimes, said: 'My daughter paid £1,100 last week for your make-up course and it's now in administration, can you please refund her money — all her savings.'
To which Jemma replied: 'We will, of course, refund, please don't worry.'
A spokesman for administrators RSM Tenon tells me: 'Unfortunately, the business has suffered from a decline in sales and we are currently seeking a potential buyer.'
Neither Jemma nor Miss Fodor replied to requests for comment.
Carolyn hides a saucy secret
Love: Prince Andrew's former flame, Carolyn Seaward, wins Miss UK
In the busy love life of the Duke of York she was sandwiched between Koo Stark and baronet's daughter Vicki Hodge.
But for beauty queen Carolyn Seaward, catching the roving eye of the young Prince Andrew did not lead to lasting happiness with a man.
Now 51, the former Miss United Kingdom, who starred with Roger Moore in the Bond film Octopussy, lives a single life with her mother Pamela in Devon and makes her living house-sitting and looking after horses.
Of her romance with the Queen's second son, she says: 'I met Prince Andrew at Dartmouth Royal Naval college when I was 19 and he very nicely invited me for dinner.
'I just went to Buckingham Palace once. We had a fun evening and a nice dinner and we ran around on the roof of the Palace but that was it. I was too young and naive, I hadn't even had a proper boyfriend by then, if you know what I mean. I was an extremely late starter on that front.'
In a forthcoming BBC documentary, Carolyn also reveals a penchant for nude sunbathing in her mother's Devon garden.
'It isn't so good now that my mother has thinned the hedge and the neighbours walk by! she says. 'But I keep very still.'
THERE were no withering Dowager Countess of Grantham-style put downs when actor Toby Stephens was growing up at home with his mother Dame Maggie Smith, alias the battleaxe of Downton Abbey.
Toby, 43, insists that neither his father actor Sir Robert Stephens nor his mother behaved in a theatrical way when they weren't on stage or before the cameras.
About to appear in Noel Coward's Private Lives at the Chichester Theatre Festival, Toby says: 'Everybody imagines, if you are from a family that acts, you spend your life as a child tap dancing and singing songs and doing speeches from Shakespeare.
'But we were kept quite distance from my parents' work. When she came home she was a mother. She went out to work and we were kept separate from that. It was a job.'
You can't imagine Masterchef host John Torode cooking for one at the best of times. And since splitting from wife Jessica, the mother of his two children, he hasn't had to rely on home cooking.
The other night he was enjoying oysters and fine wine at Battersea's Soif restaurant, where he shared a £58 bottle of Chianti Classico with a pal.
'Ladies got excited wondering who would join him at the table for two and were disappointed to see it was a male chum,' I am told. 'He doesn't seem to have lost his appetite though, he tucked into pork belly rillettes.'
Twenty years after his seminal biography of Princess Diana triggered a worldwide furore, author Andrew Morton will be starting a new chapter in his life tomorrow when he marries in California.
His bride is U.S.-born interior designer Carolyn May. It is a second marriage for Morton, who has two daughters and a grandchild by his first wife Lynne.
The wedding is at the Presbyterian church in Beverly Hills followed by a reception at Soho House in Hollywood. The couple plan to divide their time between Los Angeles and London.
As one of only two women — the other is Baroness Thatcher — who has been bestowed with the insignia of Lady Companion of the Order of the Garter, Sir Winston Churchill's daughter Mary Soames is understandably proud to be a member of the oldest order in British chivalry.
But for an entirely different reason Lady Soames, 90, will never forget the day the Queen invested her in 2005. She tells Tatler: 'The Queen said: "And this is your father's collar."
'I rather saucily told her: "Oh no, Ma'am, it can't be, it's at Chartwell"[her father's country home].
'The Queen said: "I caused it to be retrieved."
'I thought it was a wonderful way of putting it.'
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The Kensington Medium Weight Platinum Combo Turnout is offered in the Surefit® design to fit a variety of body confirmations ranging from narrow and lanky to broad and stocky. The outer shell is a 1680 denier ballistic nylon with Teflon® and Lami-Cell® coatings. The turnout is waterproof and highly breathable with CoolPlus® inner lining, which helps reduce excess moisture from the horse while still maintaining warmth. The 180 gram hollow fiberfill insulation offers enough insulation to keep your horse comfortable in most temperatures. This combo includes an optional/detachable Neck Warmer with the same 1680 denier ballistic nylon outer shell and 180 grams of insulation. Blanket features include detachable criss-cross belly straps, a removable belly band, a detachable tail flap, removable rear leg straps and QuickClip closures at the front chest.
The Kensington Heavyweight Platinum Combo Turnout Blanket is cut to fit a variety of body confirmations. Waterproof and breathable, the outer shell is 1680D ballistic nylon with Teflon® and Lami-Cell® coatings. CoolPlus® inner lining helps reduce excess moisture to remove any worry that your horse would feel damp. This combo includes an optional/detachable neck warmer with the same 1680D outer shell and 300 grams of Hollow Fill.
This Rider's International Supreme Medium Weight Turnout Blanket features a 1,200 denier ripstop nylon outer shell and 200 grams of fill to keep your horse warm and dry. A durable and attractive mid-weight turnout blanket.
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The NorthWind® Detach-A-Neck Heavyweight Turnout Blanket is nearly indestructible with its super-tough, waterproof 1680 denier ballistic nylon outer. The blanket keeps your horse warm with 350 grams of poly fill; the removable neck cover has 150 grams of fill. Comes with a lifetime guarantee.
The Rider's International NorthWind® Detach-A-Neck Medium Weight Turnout Blanket has a 1680D ballistic nylon outer shell that keeps your horse warm, dry and protected from the elements. The blanket has 200 grams of poly fill; removable neck cover has 100 grams of fill. Smooth linings glide over your horse's coat.
The Rider's International NorthWind® High Neck Turnout provides more coverage in cold weather. The 1680 ballistic nylon outer shell provides protection from wind, rain and rips--and is so tough it comes with a lifetime guarantee. This winter blanket features 350 grams of fill for extreme warmth and a coat-smoothing nylon lining.
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Star Tracks
McAdams has another major moment at an About Time premiere in Germany. Plus: Jen & Ben, Channing Tatum, Katy Perry and more
Credit: Andreas Gerbert/Landov
Published: Monday Aug 12, 2013 | 07:00 PM EDT
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Recipe: Meatball Pasta Bake
Orange juice and fennel give this quick supper bright, fresh flavor. Chop fennel as you would an onion, or omit it, if desired.
Beckon your family to the table with the promise of piping-hot, delightfully casual combinations of ground beef with noodles, cheese, and colorful vegetables.


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My car keeps shutting off while driving. I replaced the battery and fuel pump. on 1993 Jeep Grand Cherokee
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Utah Jazz come back to top the Blazers
PORTLAND, Ore. — Know that shooting slump C.J. Miles struggled through the past couple of weeks?
Yeah, it officially ended in a big way Saturday night.
If that wasn't clear after he drilled back-to-back 3-pointers in the first half against Portland, you might have had a clue his cold spell was over after he fired in a couple more long bombs in the third quarter.
After a sizzling fourth, the bottom of the snapping visitors' nets were simply calling out for mercy. That sympathy plea sounded like this: Swish, swish, swish, swish and swish.
By the time Miles was done tickling the twine and torturing the crowd, the Jazz's sixth man had drained a career-best seven 3-pointers, scored a season-high 25 points and shot his team to a 103-94 victory.
"He bailed us out big-time," Jazz point guard Deron Williams said. "He shot it and shot it well, especially when it counted."
Miles' five fourth-quarter treys helped spark Utah to yet another double-digit come-from-behind win on the road — the Jazz's sixth of that sort this season, if you're counting.
Struggling to get going a night after a lackluster loss to San Antonio in Utah, the Jazz fell behind the Trail Blazers by 11 in the second quarter.
But Utah closed that gap to three by halftime, and showed renewed signs of life.
Road, sweet road. Go figure.
"We were hanging in there," said Jazz fill-in coach Phil Johnson, who again subbed for a funeral-attending Jerry Sloan. "At halftime, I felt like we had a chance if we just played strong."
The Jazz saved their best for the final quarter, which is their specialty this season. The Blazers entered the fourth with a nine-point lead after a bizarre turn of events, which included Jazz assistant trainer Brian Zettler getting called for a technical, one of Miles' rare misses ending up resting on top of the backboard and Miles missing a dunk.
But it was all Jazz after that.
Utah surged to an 82-80 lead thanks to a quarter-opening 17-6 run, which included two of Miles' threes.
And he was just getting warmed up on his 7-for-10 3-point shooting night.
This coming from Miles, who missed 12 straight from long distance over three games earlier this season and who had only hit 4 of his last 29 from beyond the arc.
"It was tremendous. … He's a good shooter," Johnson said of Miles, who didn't practice earlier this week because of a sore lower back. "He's actually struggled this year. He's had some injuries and he's been banged up, but he came out strong and got after it."
Did he ever.
It helped that Miles felt like he was shooting through a hula-hoop after an early dunk and those first treys gave him a shot in the arm.
"The basket started to look big," Miles said. " It just started opening up."
Miles wasn't the only thorn inside the Rose Garden in this barnburner.
Backup point guard Earl Watson scored zero points but gave a gutsy effort in spearheading the fourth-quarter charge. Ronnie Price had five points and provided five times that much energy.
Center Al Jefferson, who was almost nonexistent in Friday's loss, bounced back nicely with 20 points and 14 rebounds.
Paul Millsap added 15 points, Andrei Kirilenko had 13 points and Williams contributed a double-double of 12 points and 11 assists.
"We had a tough loss last night and they accepted the challenge and came out," Johnson said, referring to the 94-82 clunker against the Spurs. "(Miles) shot the ball, a lot of guys really contributed. Al played tremendous tonight, coming back after a tough night last night."
And Johnson really appreciated the effort by Watson, who played much of the fourth quarter and had six assists, two steals and two rebounds.
"Earl Watson didn't score a point, played very well," Johnson said. "It's amazing how this game is. He defended, got us in our offense … a lot of guys contributed."
LaMarcus Aldridge ended up with 24 points for Portland, which got outscored 38-20 in the fourth quarter. Former Jazzman Wesley Matthews had 16 points on 6-for-16 shooting.
But, like so many other teams around the country have felt, they were left wondering what had happened and how they'd lost a double-digit lead to the 9-5 Jazz.
How does Utah do it?
"We get down, that's why," Johnson quipped. "It's either that or lose, you have your option. I said this all the time: We're a work in progress. We've got new guys. We have to bring them into the way we play basketball. It's going to be a long haul for some of the guys."
Especially teams they play on the road.
And especially if Miles continues to shoot like this.
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Not long after British actor Ben Whishaw debuted onscreen in the late '90s, he began to reveal a gift (and a proclivity) for essaying some of the more intense and unusual characterizations in contemporary cinema, occasionally delivering uncanny evocations of real-life figures. Whishaw was memorable as a young Keith Richards in Stephen Woolley's Brian Jones biopic Stoned (2005), then portrayed a demented young man so determined to capture "the scent of womanhood" that he resorts to serial murder in Tom Tykwer's psychological thriller Perfume: The Story of a Murderer (2006). Whishaw evoked a young Bob Dylan (one of many) in Todd Haynes' controversial avant-garde biopic of the folk singer, I'm Not There (2007), then signed on to portray famed author John Keats in director Jane Campion's dramatization of the Keats/Fanny Brawne romance, Bright Star (2008). That same year, audiences could catch Whishaw's portrayal of Sebastian in Julian Jarrold's big-screen Evelyn Waugh adaptation , Brideshead Revisited (2008). In the years to come, Winshaw would remain a bankable actor, with prominent roles in films like Skyfall and Cloud Atlas. ~ Nathan Southern, Rovi


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I know this question has been asked before, but non of the solutions solve my problem, so I'm asking this again. I am trying to call a method on self as the result of a callback through a block. I'm getting the following error:
Capturing 'self' strongly in this block is likely to lead a retain cycle
- (void)viewDidLoad {
[super viewDidLoad];
self.webClient.completionHandler = ^{
[self populateData];
I tried doing something like the code below, and I'm still getting the same warning. What's the solution?
__weak id myself = self;
[myself populateData];


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From Our Editors
As visitors to Spa Theology slip into plush robes and slippers and nibble organic treats in the relaxation lounge, stress falls away—so does the rest of the outside world. Evoking a secluded country farmhouse perpetually filled with warm, late-afternoon light and truckloads of all-organic crops, the spa spirits guests away to a realm of rough brick walls, creamy curtains, and recessed nooks glowing with tea lights. Once pamperees have reached at least a level eight on the ahhmeter, they're ushered into a treatment room to be plied with only botanically-based, paraben-free salves.


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I hope you didn't put away those Fourth of July decorations yet, because with the games in London just around the corner, you've got the perfect excuse to theme-out another party. Invite the neighbors, or just spice up TV watching for you and the family.
Patriotic tablescapes are easy as two rolls of streamers. The one above works for many different countries – USA, UK, France or Australia – but you can change up the colors to show your Italian, Dominican or Hungarian pride. Recycling and creating simple decorations saves you time and keeps this get-together casual.
Make it a pot-luck. Your neighbor's potato salad versus your sweetheart's Southwestern corn on the cob? We think they both deserve the gold. Maybe throw together a modern ambrosia salad since it has legendary ties to Olympus.
Bring the fun and games with easy entertainment like judge's scorecards for everyone. If you feel like doing a little prep work, look up some trivia or make Olympic bingo cards for things you see on screen like different countries' flags, "uneven bars," "hugs coach" or "false start."
Get inspired. If the idea of watching the world's best athletes in action has you rethinking your own workout routine, Eversave can help! Enter our Gold Medal Giveaway and you could win a Wii Fit (plus a Wii Console), a $100 Visa Gift Card or a subscription to Women's Health or Men's Health.
Swimming and gymnastics are supposed to be big events this year. What's your favorite event to watch?


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Heritage Hotels to Build in Old Town Albuquerque
Monday July 28th, 2014 - 10:09AM
These are shortcuts to your favorite social networking and bookmark sites. Add this story to your Facebook page, del.icio.us, DiggIt, and many others!
ALBUQUERQUE, NM—Plans have been finalized for a new multimillion-dollar hotel in Old Town here, according to Heritage Hotels and Resorts, Inc.
The 118-room project will break ground by late fall with completion set for spring 2016.
The property will be built adjacent Hotel Albuquerque and will share Hotel Albuquerque's pool, ballrooms and chapel. The hotel will have five levels with guestrooms designed to extend outdoors onto terraces showcasing views toward the Sandia Mountains and downtown skyline.
"We're creating a hotel where guests will experience the true culture of New Mexico in a way that has never been done before," stated Jim Long, CEO, Heritage Hotels & Resorts. "We are blending ancient building techniques from New Mexico Native Americans with modern amenities and designs from the best designers in the world to create a new hotel that will redefine and advance the architectural building style in our state."
Global design firm Gensler drew inspiration from the Anasazi people and the indigenous ruins of Chaco Canyon. "The design creates an unprecedented architectural aesthetic for New Mexico and the greater Southwest region," stated Adam Gumowski, design director at Gensler. "Heritage Hotels and Resorts presented a captivating conceptual vision as a catalyst for the design team. The result is a one-of-a-kind property that embraces the spirituality, sensibility and legacy of the indigenous ruins of Chaco Canyon, while simultaneously striving for a contemporary sophistication."
Specific designs that have been incorporated from the Native American cultures include building the hotel in solar alignment. The hotel will be constructed so the property's solar orientation can make the most of heat in the winter and coolness in summer. Guestrooms will be deeply recessed to allow for solar gain in winter but protect from the sun in summer. The hotel's five floors will be built in traditional stacked pueblo style with the façade stepped back at the upper floors.
Local landscape architect Mimi Burns of Dekker Perich Sabatini has designed a landscape reflecting the randomness of raindrops touching the earth. She also will design gardens and open areas.
Interiors of the hotel will done by Santa Fe-based designer Kris Lajeskie. The color palette for the project will be the natural wool colors used by the master weavers of the Navajo reservation.
Other plans include a signature restaurant featuring modern Native American cuisine, a spa, a rooftop restaurant and a rooftop wedding chapel.
Hotel Albuquerque will be the owner of the new hotel and will be managed by Heritage Hotels and Resorts.
Tags: Heritage Hotes and Resorts • Old Town • Hotel Albuquerque • Hospitality • Construction/Renovation •
Well, it's halfway through 2016, and not much has changed since the beginning of the year. Despite the terrorism acts in Orlando, FL and Turkey, and the Brexit referendum, little has happened to affect the travel industry. Overall, things might have slowed a bit, but a majority of the fundamentals are holding steady, including occupancy, ADR and RevPAR. I've been asked why this cycle has lasted longer than those preceding it. As far as I am concerned, it's due to a single phrase: Never Again.
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Top Definition
The art of taking a steamy shit into a females mouth and then throat fucking her till the poo explodes out of her anal cave or pussy.
This stupid bitch Harper would not shut up so i was forced to feed her a beau sandwich.
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I've fairly new to word press but decided I wanted to go full swing into things and design my own theme. Considering I am fresh meat are their steps I should take to creating the theme? Like write the css file before doing the templates visa versa? Could someone explain to me the steps they take in constructing a theme?
I have in mind the basic structure for the site. How I would like it to look. I'm trying to gauge also how many template files I need to create. I want to have two sidebars one for either side. So far I figure I'll have the following templates: header, footer, sidebar, and sidebar_left, and index, 404, page, single.
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By Jeremy Konrad Wrestling comics in the past and up until now have been…not so great. No matter what publisher has tried to do it, wrestling has not lent itself to adaptation in this medium. Nobody has ever focused on what makes professional wrestling as entertaining as it is. The performers themselves are superheroes come… Read more »
By Jeremy Konrad Hasbro held their Marvel Legends panel Saturday afternoon, including plenty of reveals for their 3 3/4 and 6 inch scale lines, 12 inch line, and new role play items. They started by showing their two SDCC Marvel Legends exclusives, the Collector's Vault, which has in scale figure including Howard The Duck and… Read more »
This is Squirrel Girl. And this is John Barrowman. And from behind, obviously…Doesn't he look fine? Check out Christine's rundown of the Eisners, now with photos, right here.
Octavio Karbank writes, As the panel began, you could feel the audience's nervous energy. Everyone was ready for the show to start and for his or her favorite actors to come on stage. Nobody knew what to expect, but by panel's end, it was pretty clear those same expectations were blown to high heaven. Once… Read more »
Matt Fraction has taken the decision to revisit his earliest work for Marvel Comics. As he says in the Milkfed newsletter, What advice would I give the writer I was ten years ago, just starting out? What do I think of that work now, what do I like, what don't I like, what works, what doesn't?… Read more »
I quite enjoyed Rise of the Tomb Raider last year, with it becoming a very confident step for the series. The Xbox One exclusive was never going to be an exclusive forever though, and we now have the date for the PlayStation 4 version of the game. The version of the game is called the 20… Read more »


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Loss of Lives in Clinical Trials...
Archeologists have been known to sift through the contents of long-abandoned privy pits in their search for historical pay dirt. Now it appears the archeologists will have the company of scientists wielding the tools of genomic science. Microbiologists, for example, have demonstrated that fossilized fecal samples preserve the remains of ancient intestinal and environmental microbiota. By subjecting the microbiota to genomic analysis, the microbiologists can reconstruct long-passed microbial communities and the genetic transactions that animated them—practically carrying out, in miniature, the work of archaeologists, sifting through left-behind materials, bringing to light the activities of bygone societies.
In one recent investigation, microbiologists studied the viral community of a 14th-century coprolite, or fossilized fecal specimen. The coprolite, which had been taken from a closed barrel in a Middle Age site in Belgium, yielded viruses known to infect eukaryotes, bacteria, and archaea. In some cases, the presence of viruses was confirmed by ad hoc suicide PCR. Most important, through the application of metagenomic analysis, the microbiologists were able to discover that the viral community contained genes for antibiotic resistance.
The scientists, based at Aix Marseille Université, look forward to publishing their findings in the May issue of Applied and Environmental Microbiology. An early version of their article, entitled "Viruses in a 14th-century coprolite," appeared online February 7. In the online article, the authors wrote: "The coprolite DNA viral metagenome was dominated by sequences showing homologies to phages commonly found in modern stools and soil [and, hence, the human gastrointestinal tract]. Although their phylogenetic compositions differed, the metabolic functions of the viral communities have remained conserved across centuries."
One of the conserved metabolic functions was antibiotic resistance, as the investigators confirmed by detecting genes for resistance to toxins and antibiotics in the viral metagenome. It would appear, suggested lead researcher Christelle Desnues, that viruses were capable of passing these genes to gut bacteria and thereby protecting them from toxins and antibiotics. These viruses were active long before antibiotics were used in medicine, but both toxins and antibiotics are common in nature. Indeed, phylogenetic studies have demonstrated that the evolution and dissemination of resistance genes started well before the use of antibiotics.
"Our evidence demonstrates that bacteriophages represent an ancient reservoir of resistance genes, and that this dates at least as far back as the Middle Ages," said Desnues. And, as Desnues and her colleagues noted in their article, the "persistence of metabolic functionalities across centuries may reinforce the crucial role of the viral community in the human gastrointestinal tract." Despite reflecting inter-individual taxonomic variability, the medieval viral genome's metabolic profile was significantly conserved—a characteristic also seen with other viromes from the same ecological niche. In this case, however, the virome that was analyzed lost its viability long ago.
"We were interested in viruses because these are 100 times more abundant than human cells in our bodies, but their diversity is still largely unexplored," said Desnues. "In the present study, we thus focused on the viral fraction of the coprolite by using, for the first time, a combination of electron microscopy, high-throughput sequencing, and suicide PCR approaches."
Characterizing the medieval coprolite virome's diversity, the researchers indicated that it "displayed higher species richness (315.279) and seemed to be more functionally diverse (average Shannon-Wiener index of 4.8693) than modern stool viromes (average species richness of 77.824 and average Shannon-Wiener index of 4.1264)." Other differences, the researchers added, "included an overrepresentation of lipid transport and metabolism, fatty acid biosynthesis, and amino acid transport and metabolism."
Desnues and her collaborators are currently conducting further studies on the fungi and parasites in the coprolites, which she says will be of interest not only to microbiologists, but to historians, anthropologists, and evolutionists.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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Device Translates Dogs Thoughts Into English [VIDEO]
I absolutely love dogs, and I like to think it's because I understand them. Now there is a device that can do the understanding for me, and say in plain English what a dog is thinking about.
I absolutely love dogs, and I like to think it's because I understand them. Now there is a device that can do the understanding for me, and say in plain English what a dog is thinking about.
WTF were these two thinking? A mother and son in New Mexico are being charged with animal cruelty after posting a picture of their dog 'Baby' inside of a Ziploc bag on Facebook.
No matter the size, when little dogs need to fire one off, they go for it. Here's a compilation of a bunch little dogs trying to have there way with dogs that could easily eat them for breakfast. I love how most of them just stand there and take it.
Yesterday, Kevin Rose, one of the founders of the Digg.com, uploaded a YouTube video of his tiny dog getting into it with a raccoon on the stairs outside his house. At first, it looks like the dog was losing until Kevin runs in grabs the raccoon, and violently throws it down the stairs.
Talk about a real 'doggy' bag! Tampa resident, Thomas Elliot Huggins, 25, was recently arrested for killing a 6-month-old pit bull, chopping up the animal, eating parts and storing portions of it in the freezer for later consumption.
Even though we all know it's not safe to leave pets in a vehicle on a hot summer day, morons still do it. Some feel if you they leave the window cracked it will be just fine, this video proves it's not fine. Watch and see just how hot it actually gets.
It doesn't surprise me that its a "French" bulldog that this happens to, because we all know the French are afraid of just about everything. So, why wouldn't their dog be too. However, what I did find surprising, is the same thing that happens in this video, happens to Chris Monroe all the time.
Dogs really are mans best friend, and in this case grandma's too! Watch as Wiley cries over the grave of his handlers grandmother. According to information on the YouTube page, Wiley has never done this before. Ahhhhhhhhhh!
Now that the election is over, we can go back to being annoyed by the usual stuff on Facebook -- Farmville updates, the unceasing stream of invites to comedian friends' weekly shows, pictures that promise "likes" will somehow generate something for somebody somewhere ... and everybody's pets.
Our pets are good at tons of things, like getting stuck in jars and sneaking into pictures for awesome photobombs. They possess talents a bunch of other animals would envy. But did you know our four-legged friends are really, really good at playing dead?


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I was Attacked by Miami-Dade Metrorail Security Guards for Taking Photos and Shooting Videoby Carlos Miller
Jan. 22, 2013
German Officials Respond to Migrant's Axe Attack by Calling for 'Mandatory Islam Classes'
Finland: Man Thrown in Prison For Using "Excessive Self-Defense" Against Home Invaders
Obama's Half-Brother: I'm Voting Trump!
Black Lives Matter Protesters Block Bridge During Child's Medical Emergency
Steve King Doubles Down: Idea Every Culture is Equal "Not Objectively True"
I was attacked, choked, suffocated and handcuffed by 50 State security guards for shooting video on the Miami-Dade Metrorail Sunday night, escalating a pending state lawsuit into a possible federal suit.
As you will see in the above video, they tried to push me down the escalator and I shoved back in order to defend myself, which prompted at least three security guards to pounce on me, including one security guard named R. Myers who violently choked me to the point where I thought I was going to die.
I was video recording on my iPhone and my friend was recording on his camera. Both of us ended up handcuffed and detained until City of Miami and Miami-Dade police arrived, both who knew right away who I was.
We were released an hour later with a $100 citation accusing us of "producing loud or excessive noise," which is a lie.
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The Station Hotel was built in 1880 and is located in Gloucester opposite the train station. It is only a 5 minute walk from the bustling Gloucester city centre. The Station Hotel is a very popular meeting place for all those who visit, work and live in Gloucester.
There are 21 recently refurbished en-suite guestrooms at the hotel which all include TV, tea/coffee making facilities, Wi-Fi and a hairdryer.
While staying at The Station Hotel guests can enjoy some tasty food in the very traditional restaurant, there is also a café bar, a sports bar and a very comfortable lounge area
Located just 20 miles away from the Station Hotel is The Forest of Dean and Cheltenham and its race course are only 8 miles away from the hotel.
The Gloucester Cathedral which dates back to 1300 years is just a short walk away.
Tea & Coffee making facilities
Restaurant/Dining Area
Digital TVs
Free Wi Fi
The Station offers a range of traditional English fayre and dishes inspired by the continent, offering a wide choice to all our diners.View Our Menu
Relax in the bar area or sit back in the lounge and watch the world go by with a real ale or glass of wine, perfect for anytime of day.
Gloucester's rich history and heritage are just moments from the Station Hotel, with wonderful medieval sites such as St. Oswald's Priory,Gloucester quays,and the famous Kingsholme rugby stadium there's something for all the family.
About the area
The City of Gloucester has a unique history from its Roman foundations to its Victorian docklands. Gloucester is a vibrant multicultural city that combines historic architecture with a unique blend of visitor attractions, festivals and entertainment, a collection of high street and specialist shops and a mouth watering array of tea shops, restaurants, wine bars.
Bruton Way, Gloucester, Gloucestershire GL1 1DE
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Suzuki M109R ('06-'08) - - - Show off that Phat rear tire and clean up the tail of your M109 - with this great Baron product. - - Dynamic LED lighting recessed into this compact chrome frame - provides bright night time illumination for your license plate. - - Integrated, one-piece hidden mounting platform replaces the bulky - factory black plastic license mount assembly - quickly and easily! - - Streamlined, recessed signal mounts allow you to use either the - stock turn signals or your choice of custom marker lights, such as - Marker Lights sold separately. Baron BA318100Baron BA-3181-00
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A 3-D carbon nanotube mesh enables rat spinal tissue sections to reconnect in culture.
Microbial Ice-Makers
April 26, 2016|
How one bacterium turns water into ice at nonfreezing temperatures
April 26, 2016|
How one bacterium turns water into ice at nonfreezing temperatures
April 13, 2016|
"Ego dissolution," and other things that happen to the human brain on LSD
April 12, 2016|
With The Scientist's Top 10 Innovations competition here again, it's time to consider the best new life science tools, technologies, and methodologies.
April 11, 2016|
Researchers create a new tree of life, largely composed of mystery bacteria.
April 11, 2016|
Researchers replicate the methods used in a falsified 2014 study that claimed short, in-person conversations could sway attitudes on same-sex marriage, this time reporting that the technique worked on people initially opposed to transgender rights.
April 7, 2016|
The immune cells—known for clearing dead cells—also chew up live progenitors in neurogenic regions of mouse brains.
April 7, 2016|
Analyzing resting brain scans, researchers can anticipate the brain activities of a person performing a range of tasks.
April 4, 2016|
People are attracted to others whose emotions they feel they can easily understand, according to a neuroimaging study.
April 1, 2016|
In recent years, research has demonstrated that microbes living in and on the mammalian body can affect cancer risk, as well as responses to cancer treatment.
April 1, 2016|
Understanding cancer's relationship with the human microbiome could transform immune-modulating therapies.


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SDCC: Marvel: Spider-Man and His Amazing Friends Panel
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Chronicling the family of Hulks gets even more epic when the Banner clan joins Marvel's Chaos War. We spoke with writer Greg Pak about the upcoming clash of gamma irradiated powerhouses with the god of chaos.
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