text:
Don't let the name fool you. This open-faced take on the classic Southern breakfast sandwich is an all-out knife-and-fork affair. Crispy, » more
This leaning tower of doughnut sits lopsided on its tray as if slouching from the weight of its own deliciousness. One » more
Calling these crackly golden beauties "plain" is downright unfair. Words like butter, classic, or legit better describe the French pastries made » more
Very few things in life are served to you on a silver platter these days, never mind with an icy cold » more
If giants were real and they had a sweet tooth, they'd eat this indulgent creation. Bring a buddy or prepare for » more
You think Krispy Kreme and milky coffee is oh-so-very American? This Chinese take on the wonders of hot, tender fried dough » more
This vegetarian take on country-fried steak and gravy hits all the recognizable pleasure points: solid golden crunch, smooth white gravy, and » more

subset: commoncrawl


text:
Mercure Hotel Dortmund City, Dortmund
- Free WiFi
Main amenities
- 82 guestrooms
- Breakfast available
- Bar/lounge
- Self parking
- 24-hour front desk
- Front desk safe
- Laundry service
- Meeting room
- Multilingual staff
- Luggage storage
For families
- Free cribs/infant beds
- Rollaway/extra beds available
- Connecting/adjoining rooms available
- Private bathroom
- Laundry facilities
- Blackout drapes/curtains
What's around
- Museum of Art and Cultural History (0.2 mi / 0.3 km)
- Hansaplatz (0.2 mi / 0.3 km)
- Dortmund Concert Hall (0.2 mi / 0.3 km)
- St. Reinold's Church (0.2 mi / 0.3 km)
- Marien Church (0.2 mi / 0.4 km)
Mercure Hotel Dortmund City, Dortmund
Hotel Info: 866-539-8117from $64
- Standard Room, 1 Single Bed
- Superior Room, 2 Single Beds
- Standard Room, 1 Double Bed
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 82 rooms
- This hotel is arranged over 3 floors
- Check-in time 3 PM-Midnight
- Check-out time is Noon
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed *
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi and wired Internet access in public areas
- Free WiFi and wired Internet access in rooms
- Self parking *
Nearby Three Star Dortmund hotels
In the hotel
- Buffet breakfast daily (surcharge)
- Bar/lounge
- Conference space size (feet) - 560
- Conference space size (meters) - 52
- One meeting room
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 1
- Elevator/lift
- Safe-deposit box at front desk
- Accessible bathroom
- In-room accessibility
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Minibar
- Iron/ironing board (on request)
- Blackout drapes/curtains
- Soundproofed rooms
- Private bathroom
- Shower only
- Pay movies
- Satellite TV channels
- Desk
- Free newspaper
- Free WiFi
- In-room safe
- Connecting/adjoining rooms available
Top Dortmund hotels
Recently reviewed hotels in Dortmund
- Art Hotel KörschenFrom
"Rather tall over 6'7" , so bed and room weren't great, sleep not great. It wasn't close to the city, and the rate was good. Other than that, moderate in every other way."Jun 11, 2016
- Hotel Rhein-RuhrFrom
"Hotel was accommodating for early check in and reserving meeting space for small group business meeting."Jun 10, 2016
- McDreams Hotel Wuppertal CityFrom
"I stayed at the hotel to attend a large trade show in Dusseldorf. Bathroom and shower were very clean and worked well. Check-in was very efficient and the staff was helpful and…"Jun 7, 2016
- Mercure Hotel Plaza EssenFrom
"Very nice and comfortable hotel with a good location close to shopping, museum and downtown commercial district. Decor was very modern with lots of Windows with natural light.…"May 24, 2016
Nearby hotels
Special features
DiningLobby Bar - Onsite lobby lounge. Open 24 hours.
Mercure Hotel Dortmund City, Dortmund's small print
Also known as
- Mercure Dortmund City
- Mercure Hotel Dortmund City
- Accor Hotel Dortmund City
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
Business travelers may be exempt from the Dortmund city tax and may contact the property for further information or ask the hotel at check-in. Guests can contact the property using the information contained in the confirmation received after booking.
- A 7.5 percent city/local tax will be charged
Optional extras
Self parking costs EUR 9 per day
Rollaway beds are available for an additional charge
Buffet breakfast is offered for an extra charge of EUR 18 per person (approximately)
Pets are allowed for an extra charge of EUR 15 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Excellent 4.1 /5 from 126 reviews
A brief stay for business
I was there for buissness trip. All the things from the hotel staff to the cleanliness, the room comfort and the the LOCATION were excellent.
We were on a family trip to see the German Christkindlmakt and went to Dortmund to see a soccer game at Signal Iduna Park. This was an amazing experience with a great home crowd cheering the entire game. The hotel was very convenient, within walking distance from the train station. The subway access was near the hotel entrance and there shops and restaurants nearby. We were able to walk to the Christkindlmkt within a block.
It's a nice hotel at a nice location
No frills solid 3 star hotel in downtown Dortmund. Basic clean room, basic amenities, but great location that lets you walk everywhere.
Is the description of this hotel not correct? Tell us


text:
You can find numerous commercial truck driving businesses out there. Despite the fact that most of these firms vary in a variety of ways each one has numerous things alike. The thing of which they have in accordance would be the actual number of faithful drivers of which are working for them. All of these individuals devote thousands of hours on a yearly basis ensuring that f150 truck accessories are brought on time. Having said that, these types of vehicle operators usually are not generally dealt with as they should be.
Businesses have to understand that the actual commercial drivers they have hired are out there representing them all on open roadways. Just how folks normally see your personal drivers is actually how your personal corporation is generally seen. Sadly, lots of people misbehave even when operating these business trucks and also give their own organizations a poor name. That's why it's important for firms to take the quarrels which get reported by the population seriously and act when needed.
Proper schooling is undoubtedly important with regards to business truck drivers. In fact, most professional truckers are generally forced to take an actual class and pass both a written and driving test. However, even though most of these motorists receive their own certificates it doesn't mean they should discontinue training. It's a good idea for employers to actually demand their very own vehicle operators to successfully brush up on their particular driving abilities every once in awhile. This gives driver operators the chance to evaluate their dodge truck accessories and their fundamentals.
Bosses must also be more conscious of exactly how they handle their own drivers. Operating a commercial automobile is generally hard work. Industrial drivers typically work very long hours because they must get caught up with incredibly difficult daily schedules. Businesses will help their very own employees simply by not having them all work ridiculous extents of time. Far too much driving may cause something such as reduced sleeping and something of that ranking can cause extreme damages on the open road.
These are merely several of the factors entrepreneurs ought to look at when they have professional truckers to take into consideration. Once more, your personal operators can affect the open image of your corporation. Additionally, significantly more people ought to be pushed to actually improve their capabilities every so often while using a weatherguard toolbox. Last but not least, recruiters could very well desire to prevent driving their particular workers to work way too hard.


text:
Atlanta Hawks vs Minnesota TimberwolvesMon, January 21, 2013 - 2:00 PMPhilips Arena in Atlanta, GA
We are sorry, the date for this event has already passed. This event took place on 1/21/2013. Click here to view upcoming events for Atlanta Hawks.
Still unsure? Check out our user reviews for:
Have a question? Need help? Call us at 800.477.5285


text:
The Harris Conservatory for the Arts, a 501 (c) (3) organization, was formed to serve as a cultural center for the arts, and to act as a resource for children, adults and artists who seek to enrich their lives through arts education and activities. The goal of the Conservatory is to provide services to the underprivileged and disabled in the hope that everyone will have the opportunity to benefit from experience in the arts. Our organization believes that the arts can positively change lives and reach those who cannot otherwise be reached.
Visit Us At The Harris Conservatory For The Arts
We are excited to announce that Kirby Kidz, our summer theater program, a partnership with the F.M. Kirby Center, can officially announce the productions set for this August. This year Miss Theresa Kloeker (director and choreographer) and Mrs. Doreen Ignatovich (musical director) are teaming up once again for our two shows!
This year children ages 5 to 11 years have the opportunity to participate in the magical story of Disney's Peter Pan Jr. Based on the Disney film and J.M. Barrie's enchanting play, Disney's Peter Pan JR. is a modern version of the timeless tale about a boy who wouldn't grow up... with no flying required! The score includes new arrangements of classic Disney songs and a story featuring one rousing adventure after another. Wendy Darling loves to tell stories to her brothers, Michael and John. But when her father announces she must move out of the nursery, Peter Pan comes to visit the children and whisks them away to Neverland. Their journey introduces them to the Lost Boys, Mermaids, Indians and even the infamous pirate, Captain Hook! It's Peter to the rescue when Wendy is taken captive by the dreaded captain, who has his own sinister plans in mind for our hero.
Actors and actresses ages 11 to 18 years are invited to be part of Legally Blonde Jr. Based on the award-winning Broadway musical and the smash hit motion picture, Legally Blonde JR. is a fabulously fun journey of self-empowerment and expanding horizons. The show's instantly recognizable songs are filled with humor, wit and sass – leaving cast members and audiences alike seeing pink! Legally Blonde JR. follows the transformation of Elle Woods as she tackles stereotypes, snobbery and scandal in pursuit of her dreams. When Elle's high school boyfriend, Warner, dumps her and heads to Harvard, claiming she's not "serious" enough, Elle takes matters into her own hands, crafting a showy song-and-dance personal essay and charming her way into law school. Befriending classmate, Emmett, and spunky hairdresser, Paulette, along the way, Elle finds that books and looks aren't mutually exclusive. As Elle begins outsmarting her peers, she realizes that law may be her natural calling after all.


text:
firstname.lastname@example.com Continuously updated all day, every day!
Santa Cruz, Frampton NYC media workout
Photos: Amanda Westcott / Showtime Undefeated featherweight world champion Leo Santa Cruz and undefeated former unified 122-pound world champion, Irish star Carl Frampton, ...
Robert The Ghost Guerrero speaks
By Miguel Maravilla Photos: John Aguon/Spike/Premier Boxing Champions Former world champion Robert "The Ghost" Guerrero (33-4-1, 18 KOs) returns to the ring against David ...
Dimitrenko: I am confident of defeating Parker
By Ray Wheatley - World of Boxing Photos: Dave Cameron Giant 6'7 heavyweight Alexander Dimitrenko (38-2, 24 KOs) has arrived in New Zealand for ...
Frampton: Santa Cruz fight "may be brutal"
By Matt Richardson In February, IBF junior featherweight champion Carl Frampton boxed in the biggest fight of his career. Unfortunately, it wasn't much ...
Leo Santa Cruz: I Will Stay on Top of Him
By Miguel Maravilla Photos: Esther Lin/SHOWTIME Undefeated WBA featherweight champion Leo "El Terremoto" Santa Cruz (32-0-1, 18 KOs) of Lincoln Heights, California by ...
Santa Cruz, Frampton NYC media1
Robert The Ghost Guerrero speaks2
Dimitrenko: I am confident of3
Frampton: Santa Cruz fight "may4
Leo Santa Cruz: I Will5
- Santa Cruz, Frampton NYC media workout
- Stevenson-Williams Officials Named
- Boxing Buzz
- Four title fights at the Orient Theatre, East London, South Africa
- Australian Brubaker unifies OPBF 147lb belts
- Dimitrenko: I am confident of defeating Parker
- Frampton: Santa Cruz fight "may be brutal"
- New South African promoter on the block
- Robert "The Ghost" Guerrero speaks
- Wilcox faces Orozco on Thursday
- Santa Cruz and Frampton: First Faceoff
and make sure you're getting the latest updates.
Late Results from Mississippi
Light heavyweight Blake Prevost (16-2-1, 5 KOs) won a ten round split decision against former world title challenger Will "Kid Fire" McIntyre (40-5-1, 14 KOs) on Saturday night at the Hollywood Casino in Bay Saint Louis, Mississippi.
Other results from promoter Leslie Bonano and Brawlin' in N'awlins' show:
Bobby O'Bannon TKO3 John Brown (heavyweights)
Jamond Bourgeois W4 Vince Burkhalter (middleweights)
Tiffany Woodard D4 Sydeny LeBlanc (heavyweights)
Marcus McDaniel W4 Blake Singleton (middleweights)
Sergio Martinez Roadwork
By Ricardo Conde
Photos: Ricardo Conde
Middleweight champion Sergio "Maravilla" Martinez (46-2-2, 25 KOs) of Argentina continues his preparations for his upcoming bout which will be against WBO junior middleweight champion Sergiy Dzinziruk (37-0, 23KOs) of Ukraine on Saturday March 12th at the Foxwoods Resort Casino in Mashantucket, CT which will be shown live on HBO's 'World Championship Boxing'.
"We're only a couple weeks into camp and Sergio is already in great shape." said chief trainer Gabriel Sarmiento. "Sergio maintains the same intensity throughout the entire camp, he's giving it 100% and I have no doubt in my mind we're going to get similar results in this fight as we did in our last fight." continued Sarmiento. (more…)
IBF crowns more female champions
The IBF is on pace to quickly reach its goal to fill all its female titles and give more championship opportunities to women around the world. On Saturday, January 22, 2011 at Estadio Neza in Nezahualcoyotl, Mexico two more IBF female champions were crowned. (more…)
Chavez Jr Homecoming
Photos: Rafael Soto/Top Rank
The last time Julio Cesar Chavez Jr. fought in his hometown of Culiacan, Sinaloa, Mexico, he was a 19-year kid fighting in his first 10 rounder against former Mexican champion Christian Solano, who at the point was the toughest opponent he had face in his young career. "I remember that night very well. I had a lot of support from the fans and it was a very special night. It was my first main event in a big fight at home and I was very excited," said Chavez Jr. That fight was back on December 16, 2006 at the Plaza de Toros.
This Saturday, January 29, Chavez Jr. returns as the number one world ranked contender in the WBC Middleweight Division to take on Billy Lyell in the Banorte Soccer stadium in Culiacan. (more…)
Chavez Jr Workout
Cauthen tops McCants
By Rick Scharmberg
Terrance "The Heat" Cauthen (36-7, 9 KOs) took a six-round unanimous decision over Philip "Mongoose" McCants (8-2-1, 3 KOs) in the welterweight main event last Saturday night at the Hamilton Manor in Hamilton, NJ. McCants was down briefly in round five. The scores were 58-53, 59-53, and 59-52, all for the former 1996 Olympic bronze medalist. In the co-feature, Charles Hayward (6-2, 2 KOs) stopped Jason Burrell (2-6-3, 2 KOs) after two completed rounds of a scheduled six round light heavyweight bout. Burrell was down twice in round two, and was ruled unable to continue for round three. The promoter of the event was Nedal Promotions. Other results…
Quigg training at Wild Card
Unbeaten WBA #9 rated super bantamweight Scott Quigg (21-0, 14 KOs) has spent £4000 of his own money in order to spend three weeks training at Freddie Roach's famous Wild Card gym. He is currently enjoying his second trip to the Los Angeles gym that also house the world's top fighter Manny Pacquiao and Amir Khan. "As far as I am concerned it is money well spent," he stated. "Sparring sessions over there are like war, harder than any fight I've had. I have sparring with champions and it has been hard, but these are sacrifices I need to make….I am getting to the stage where the opposition is getting harder so this camp in Los Angeles is helping prepare me for that."
New headliner at Turning Stone
Due to an injury to Mike Mollo, there is a brand new main event on Saturday at The Turning Stone Casino and Resort in Verona, New York as former U.S. Olympian Jason Estrada (16-3, 4 KOs) will take on Franklin Lawrence (13-2-2, 8 KOs) in a ten round battle for the WBC Caribbean Heavyweight championship. Mollo was slated to face Manuel Quezada, who is now off the card.
Quintana foe named
As initially announced on Fightnews.com, former WBO welterweight champion Carlos 'El Indio' Quintana (27-3, 21 KOs) will soon make his return the ring. The new date now is February 18th with Quintana's opponent being Ishmael Tetteh (21-6-2, 10 KOs) of Accra, Ghana. The 10 round junior middleweight main event will take place at the Coliseo Pachin Vicens in Ponce, Puerto Rico.
Fegatilli aims to outsmart Foster
European super featherweight champion Stephen Foster Jr. (28-2-1, 18 KOs) is hoping that his next opponent Ermano Fegatilli (22-4, 5 KOs) isn't as intelligent in the ring as he is outside of the ropes. The Belgian challenger, who holds a Masters Degree in Economics from Liege University in 2007, is a pure boxing stylist who will aim to outsmart Foster on February 26 in the Premier Suite at Reebok Stadium in Bolton, England. (more…)
ABC: 28 suspended fighters boxed
According to the Association of Boxing Commissions, 28 boxers have been allowed to fight while on suspension since July 2010. California was the main offending commission, allowing 9 suspended boxers to participate. Other commissions included Kansas, Shediac, Puerto Rico, Mashantucket, Montreal, Manitoba, Colorado, Iowa, Arizona, Washington, Oklahoma and Mississippi. The highest profile boxers were world rated super bantamweight Christopher Martin who fought under suspension on September 10 (Must Renew Federal ID) and three-time world title challenger Cecilio Santos who fought under suspension on December 11 (Needs Physical). The ABC draws its membership from state and tribal combative sports commissions from the United States, Canada and Puerto Rico.
Stewart headlines Feb 25
By Rick Scharmberg
Michael "No Joke" Stewart (46-7-2, 24 KOs) returns to the ring to face David "El Torrito" Torres (21-2-2, 13 KOs) in a ten round junior welterweight bout on Friday, February 25 at Dover Downs Hotel & Casino in Dover, Delaware. Stewart and Torres will box for the vacant NABA junior welterweight title. Stewart, of New Castle, DE is a former USBA champion, and has appeared on "The Contender" TV reality show. In the co-feature, heavyweight knockout artist Amir "Hardcore" Mansour (11-0, 8 KOs) will appear against an opponent to be determined. Mansour is on the fast track to a world ranking. (more…)
Pittman, Leapai return Saturday
By Ray Wheatley — World of Boxing
Photo: Tim Barry
Former WBA middleweight challenger Jamie Pittman (20-2, 8 KOs) will be in action over eight rounds when he clashes with Tim Kanofski (11-3, 0 KOs) at the Gold Coast Convention Center at Broadbeach, Queensland, Australia on Saturday. Pittman will start a red hot favorite but the tough Kanofski always comes to fight and has a good work rate but lacks finishing power.
Also in action will be WBO #14 heavyweight Alex Leapai (21-3-3, 16 KOs), who will punch it out with 36-year-old Florida heavyweight Jason Barnett (12-12, 6 KOs) over eight rounds. (more…)
Rivera Set For Ring Return
By Scott Ploof
Photo: Emily Harney
Worcester, MA's own three-time world champion Jose Antonio Rivera (39-6-1, 24 KOs) recently announced his decision to come out of retirement. After an almost two and a half year layoff, Rivera, who recently has been in training, is looking to make one last run at getting another shot at a world title. He will begin his journey in the main event on Saturday April 9th at the Palladium in his hometown of Worcester, MA on a card promoted by Jimbo Isperduli's Paxton Promotions. At this time Rivera's opponent has yet to be determined. Matchmaker for this event is Ted Panagiotis.
When asked what prompted his decision to return to the ring, Rivera stated to FightNews, "Well recently I began training in the gym to challenge myself because I got up to 190 pounds. I wanted to challenge myself to see if I could get back into the optimal condition that I once used to be in, back when I fought in a world championship fight. I began then working with the kids in the gym. My body felt good, and my conditioning was there, so I said to myself, why not fight and let's see how things go."
Mora arrives in Texas
Story & photos by Robert Hughes
For the first time in his 30 years Sergio Mora came to Texas.
"I always wanted to fight in Texas," he said. "I think you guys have some of the best fans, not only in football, but in boxing."
The former light middleweight world champion said he's excited to show Texas fight fans what a tough kid from Southern California can do in the ring, and apparently Mora (22-1-2, 6 KO) feels Texans have a streak of blood lust . . . Click here for more
Antonio DeMarco Update
By Felipe Leon
Photo: Team DeMarco
Lightweight Antonio DeMarco (24-2-1, 18KOs) is not over confident despite him being the favorite over Reyes Sanchez (20-3-1, 11KOs) for their WBC Silver championship fight slated for February 26th in Grand Island, Nebraska. The bout will be promoted by Gary Shaw Promotions and broadcast by SHOWTIME.
The southpaw DeMarco from Tijuana, MX, by way of boxing hotbed Los Mochis, described Mexico City's Sanchez as a deceiving fighter who is much better than many people tend to believe, "People have said that I am the favorite but I am not over confident. He is a dangerous fighter, he applies a lot of pressure and since my loss to Valero, and I learned that I shouldn't be over confident. I am training as if I would be fighting Manny Pacquiao." (more…)
Reveco, Caballero WBA Updates
By Gabriel F. Cordero
The WBA has affirmed that light flyweight champion Juan Carlos Reveco will continue to be recognized as champion for the moment. Reveco, who has been involved in a managerial dispute, is long overdue for a title defense and fought a non-title bout against WBA rules. "Everyone should be given the chance they deserve to seek justice," stated WBA executive vice-president Gilberto Jesus Mendoza. He explained that Reveco will be asked to explain his actions, "and then the matter will be put to a vote." He added that these "were flagrant violations," and the process will take about a week.
Mendoza also clarified the situation involving former champion and #1 rated featherweight Celestino "Pelenchin" Knight, saying that Caballero is not the mandatory challenger. "The regulation is clear, and until the Committee acts, he isn't the mandatory.
Report/gallery: Holyfield-Williams
Ringside by Brady Crytzer
Photos by Tri Nguyen / TriNguyenImages.com
Hosted in one of America's most iconic resort facilities, The Greenbrier, Saturday night's contest for the WBF heavyweight title between Evander Holyfield and Sherman Williams ended unceremoniously as, following a headbutt, the fight was declared a no contest citing that Holyfield could not see from blood in his eye after round three. . . . Click here for more
Report: Fight for the Troops
Story by Anthony Springer Jr.
Melvin Guillard told the world he wanted to remain undefeated as a member of Greg Jackson's camp. He also said he would defeat Evan Dunham.
He made good on his word.
"The Young Assassin" needed just 2:58 to dispose of the highly touted prospect in the night's main event . . . Click here for more
Roach enjoying Culiacan
Photos: Rafael Soto/Top Rank
Top boxing trainer Freddie Roach has found a new home in Culiacan, Sinaloa, Mexico where he has been for the past two weeks preparing Julio Cesar Chavez Jr. for his next fight. "I have found this to be a very great experience. I did not know what to expect but it was been great. The people are very nice and to my surprise they know who I am. I thought the only other place as was known outside of the US was the Philippines," said Roach with a smile. Roach is getting Chavez Jr. the January 29 fight against Billy Lyell, that will take place in the Banorte Soccer Stadium in Culiacan. (more…)
Photos: Holyfield-Williams
Photos: Tri Nguyen/TriNguyenImages.com
Saturday night's title fight between Evander "The Real Deal" Holyfield and Sherman "Tank" Williams abruptly ended after three rounds due to a cut over Holyfield's left eye that he suffered in the second round. Holyfield was unable to continue after three and the fight was declared a no contest because the cut was caused by an accidental head butt and the fight didn't go minimum four rounds . . . Click here for more
Report/gallery: Magdaleno-Jimenez
Ringside by Andreas Hale
Photos by Chris Cozzone
The Dallas Event Center at the Texas Station Hotel and Casino in Las Vegas featured a sold-out crowd who came to see if rising featherweight Diego Magdaleno would take home the vacant NABF super featherweight championship. Magdaleno would not disappoint the raucous hometown crowd of 1505 in one of his most impressive performances to date. One of Top Rank's fast rising stars captured the title and again showcased a more punishing demeanor as he earned a resounding fifth round TKO victory and claimed the title while improving to 18-0 with his 6th knockout . . . Click here for more
Charles defeats Vasquez
Report and photo by Rick Scharmberg at ringside
Osnel Charles (6-2) withstood a late surge by Victor Vasquez (12-5-1, 6 KOs) to win a majority decision in the six round lightweight main event last night at Harrah's Casino and Racetrack in Chester, Pennsylvania. In the co-feature, Zeferino Albino (4-12-2, 2 KOs) stopped "Big" John Poore (21-5, 18 KOs) after two completed rounds of a scheduled four round cruiserweight bout. The seven-bout card, which drew a standing-room-only crowd, was promoted by Joey Eye Boxing Promotions in association with David Feldman. It was the first-ever boxing event at the venue. (more…)
BWAA: Martinez 'Fighter of Year'
For Sergio Martinez, 2010 was a year to remember. He started by winning the world middleweight title from Kelly Pavlik, then successfully defended it with a sensational one-punch knockout of Paul Williams. As a result of Martinez's success, the Boxing Writers Association of America have voted him recipient of the "Sugar Ray Robinson Fighter of the Year" award. Martinez becomes the second boxer from Argentina to receive this prestigious honor, the first being Carlos Monzon in 1972. (more…)
UFC: Help the Troops
Even though the action inside the Octagon™ at tonight's UFC® Fight For The Troops 2 event has concluded, the Ultimate Fighting Championship® is encouraging its fans to continue to help raise funds for the brave men and women in the United States Armed Forces with traumatic brain injuries. (more…)
Photos: Holyfield-Williams
Photos: Tri Nguyen/TriNguyenImages.com
Saturday night's title fight between Evander "The Real Deal" Holyfield and Sherman "Tank" Williams abruptly ended after three rounds due to a cut over Holyfield's left eye that he suffered in the second round. Holyfield was unable to continue after three and the fight was declared a no contest because the cut was caused by an accidental head butt and the fight didn't go minimum four rounds. (more…)
Lee looks sharp in workout
By Joe Koizumi
A Japanese reporter asked this observer why on Sunday there's a public workout for the newly crowned WBA super-bantam champ Retsuri Lee (AKA Ryol-li Lee; 17-1-1, 8 KOs). He then eagerly wished to watch WBC Boxing TV by internet that would show a WBC female 115-pound title bout between Ana Maria Torres and OPBF champ Naoko Yamaguchi to be shown live from Mexico at the same time as Lee's workout. (more…)
Holyfield-Williams Post Fight Quotes
Evander Holyfield: "I'm very disappointed. He fought the way he should have. He understood he would have his head low when he threw the overhand right. If I didn't move back, we'd clash heads. It was to his advantage to get lower because he's short. Being that short he had to fight that fight. He didn't have to, he chose to."
"Stuff like this happens and I'll shake it off. Hopefully, I'll get this stitched up and it won't be a problem. Life goes on, it's part of boxing."
Sherman Williams: "I've had my own personal setbacks. To get over what I did was a miracle. I trained hard for this fight. I was fighting a legend and I can't take anything away from him. I feel like I should have won by TKO. I cut him with an overhand right, but I respect him."
"I root for him. He's almost 50 and still training and performing. I admire what he's done but it's time to let younger guys fight and older guys do television commentary. He's not as good looking as I am. You've made sacrifices, won 4 world championships and fought in the Olympics. But this is a new time, a new era. Mr. Holyfield shouldn't be taking punches from younger guys. That's how I feel. It's time for him to move on but, if he wants, we can do it again."
"After the first round he was falling into my trap. When he felt I was in retreat…bang with the overhand right, and that's when I saw blood."
Guillard destroys Dunham
Results by Anthony Springer Jr.
In the night's main event, Melvin Guillard took a step closer to the lightweight title in a dominant first round victory over Evan Dunham. "The Young Assassin" needed just 2:58 to put on a striking clinic punctuated by two big knees that found a home on the up and comer's face. The referee rushed in to halt the bout as Dunham slumped over.
Matt Mitrione made his Octagon record 4-0, thrashing Tim Hague en route to a first round TKO win. A straight left put "The Thrashing Machine" on his back and a series of right hands sealed the deal. (more…)
Holyfield/Williams Quick Quotes
Evander Holyfield: "I'm cut. He head-butted me. He came down on me with his head. I don't know about my next fight (March 5 vs. Brian Nielson in Denmark). I'm cut, I'm cut. I'll give Sherman a rematch."
Sherman Williams: "I'm back. This fight was a circus, on again, off again. But I stayed focused. I hurt him with an overhand punch. Let's bring this fight to Atlantis – Holyfield-Williams II. I'll take his place in Denmark and fight Nielson."
Oquendo destroys Santos
Photo: PR Best Boxing Promotions/José Pérez
In a clash for the NABO title on Saturday night at the Bayamón Correctional Complex 1072 in Bayamón, Puerto Rico, super bantamweight Jonathan Oquendo (21-2, 14 KOs) won by KO when he sent Cecilio Santos (25-17-3, 15 KOs) to the canvas with a body punch in the first round and Santos didn't beat the count. Time was 2:46.
In the co-feature, unbeaten 6'6 heavyweight Carlos Negrón moved to 12-0, 7 KOs after an eight round unanimous decision over Willie Herring (12-9-3, 3 KOs). Scores were 80-72, 79-73, 79-73.
Unbeaten bantamweight prospect McJoe Arroyo (8-0, 5 KOs) scored a fourth round TKO over Eduardo Meléndez (4-9, 1 KO). Meléndez was down two times in the second round and once in the fourth. Time was 1:38.
Ruiz wins WBA interim bantam belt
By Gabriel F. Cordero at ringside
10,000+ were on hand at the Estadio Olimpico Neza 86 in Mexico City on Saturday night to see HG Boxing's "4 Coronas" card featuring four world title fights. Most notably, Mexican Hugo "Cuatito" Ruiz won the WBA Interim bantamweight title with a technical majority decision over Nicaraguan Alvaro Perez. The bout was stopped at the end of round nine due to head clashes. Scores were Russell Mora (U.S.) 87-83 to Ruiz, Pasquale Procopio (Canada) 86-84 to Ruiz and Carlos Sucre (Venezuela) 86-86. Referee Mark Nelson dieducted a point from Perez in the ninth round.
Mexican Aracely Muciño won by fourth round TKO over American Chantel Cordoba to win the vacant IBF female flyweight world title.
Mexican Irma Sanchez won a ten round unanimous decision over compatriot Kathia Gutierrez to win the vacant IBF female light flyweight world title.
Mexican Ana Maria Torres won by ten round unanimous decision over Japan's Naoko Yamaguchi to retain her WBC female super flyweight world title. Judges scored it 100-89, 100-89 and 98-91 all in favor of Torres.
Holyfield-Williams no decision
By Brady Crytzer at ringside
Photo: Steven Limentani
Legendary heavyweight world champion Evander "The Real Deal" Holyfield (43-10-2, 28 KOs) and Sherman "Tank" Williams (34-11, 19 KOs) ended in a three round no-contest on Saturday night at The Greenbrier in White Sulphur Springs, West Virginia. The 48-year-old Holyfield was cut over the left eye in round two by an unintentional headbutt and rocked by a Williams right hand in round three. After the round Evander said he couldn't see and the bout was declared a no contest. The cut could very well jeopardize Evander's scheduled March 5 fight against Brian Nielsen in Copenhagen, Denmark.
In the co-feature, former heavyweight title challenger Kevin "Kingpin" Johnson (24-1-1, 10 KOs), who took the bout on short notice, won an eight round unanimous decision over 300lb, seven-footer Julius Long (15-15, 13 KOs). Johnson dropped Long twice in round eight. Scores were 79-71 on all cards.
Former heavyweight title challenger Monte Barrett (34-9-2, 20 KOs) and journeyman Charles Davis (19-21-3, 4 KOs) fought to an eight round majority draw. Scores were 77-75 Davis, 76-76, 76-76.
In an impressive display of brute power Cedric "The Boz" Boswell (32-1, 25 KOs) continued to roll stopping Dominique "Diamond" Alexander (19-10, 9 KOs) in the second round after knocking down his opponent three times with hard left hooks to the body. (more…)
Magdeleno TKOs Jimenez
By Andreas Hale at ringside
Unbeaten super featherweight Diego Magdaleno (18-0, 6 KOs) Marcos Leonardo Jimenez (18-3, 12 KOs) on Saturday night at the Texas Station Hotel Casino in Las Vegas. Magdaleno dropped Jimenez with a body shot in round one and dominated the fight. Jimenez was almost stopped in round five and the bout was halted between rounds. With the win, Magdaleno claimed the vacant NABF championship.
In his U.S. debut, unbeaten Brazilian heavyweight Julio Cesar Dos Santos (14-0, 13 KOs) was credited with a TKO when Valente Tinajero (8-4, 4 KOs) wouldn't come out for round six.
Unbeaten featherweight Roberto Marroquin (18-0, 14 KOs) impressively KO'd Eduardo Arcos (17-3, 14 KOs) in round four. Marroquin dropped Arcos with a big left hand, then finished him with another left moments later. Time was 1:21.
Highly touted featherweight Jesse Magdaleno (2-0, 2 KOs) TKO'd out Cain Garcia (0-2) in round three. Jesse fired a hard right hook which sent Garcia flying into the ropes – he touched down, tried to continue but fight was called off – spectacular performance. Time was 2:14. Jesse, whose brother Diego is featured in the headliner, was a major amateur star. (more…)
Lucero defeats Cuero
By Boxing Bob Newman
A packed house at the Crowne Plaza Hotel's Grand Ballroom came in from the cold to warm up to a night of fisticuffs in Albany, New York as Ares Promotions presented Fight Night III. Headlining was former Manny Pacquiao title challenger Emmanuel Lucero, who took a ten round unanimous decision over Oscar Cuero in a super featherweight clash. (more…)
All contents copyright 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016 by Freitag Marketing Services, LLC. The information on this site cannot be reused without written permission.


text:
To contact "Hanging Tie Rack" suppliers, select Check Box and click on "Inquire Now".
Related Products: Garments Hanger | Garment Rod Hanger | Galvanized Hanger | Folding PP Hangers | Flannel Laminated Hanger
To contact "Hanging Tie Rack" suppliers, select Check Box and click on "Inquire Now".
Login or register for immediate download
Note: Magazines are available in English only.
Get in-depth market information & more on these verified suppliers:
See also companies of Clothing display racks, Children fashion mannequins, Women fashion mannequins, Belt hangers, Men fashion mannequins
Above Hanging Tie Rack suppliers include wholesale Hanging Tie Rack, Hanging Tie Rack from China, India & Worldwide. Back to top of the page for chinese Hanging Tie Rack.
Can't find the product you want? Tell suppliers what you need and get quotations!
Please select your preferred language:
If you wish to change the language or use the original language later, please refer to the header or footer for more language options.
Contact the supplier of your choice. It's fast, precise and secure.
Contact all suppliers . It's fast, precise and secure.
Min. Order:
FOB Price:
Certs: More...
Learn more
Learn more
View all
Come and meet us at the Fair! Register
Come and see our product at the Fair!Register
This supplier has exhibited at one or more of our specialized sourcing Trade Shows
Click here to learn more about this supplier
Learn more
Please select an item(s) before clicking "Inquire Now" or "Add to Basket".


text: Missions Category page 11,242pages on this wiki Edit History Talk3 Sorting type: Most visited Most visited Alphabetical | This category lists the following articles about Missions within the Grand Theft Auto series. Pages in category "Missions" Hit 'Em Up Shogun Showdown Hung Out to Dry Triathlon (TBOGT) Death From Above Wet Workers Grease Sucho Cipriani's Chauffeur More Deadly Than the Male Jamaican Heat Rumble The Parking Garage The Crook Cleaning House Hose the Hoes Hit the Pipe Back 1 ... 41 42 43 44 45 46 47 ... 78 Next Subcategories Missions in GTA Liberty City Stories Crossovers Missions in GTA Vice City Stories VIP Work Missions in GTA Chinatown Wars " This category lists transcripts for missions in the GTA Series. Transcripts Adversary Modes Stadium Events Walkthroughs Missions in GTA 2 Missions in The Lost and Damned Missions in The Ballad of Gay Tony Missions in GTA Online: Lowriders Missions in GTA London 1969 Missions in GTA 1 Missions in GTA Advance Back 1 2 Next Media in category "Category:Missions" Repossession13-GTAV.png Posted in: Repossession Repossession14-GTAV.png Posted in: Repossession Repossession17-GTAV.png Posted in: Repossession Repossession18-GTAV.png Posted in: Repossession Repossession2-GTAV.png Posted in: Repossession Repossession3-GTAV.png Posted in: Repossession Repossession4-GTAV.png Posted in: Repossession Repossession5-GTAV.png Posted in: Repossession Repossession6-GTAV.png Posted in: Repossession Repossession7-GTAV.png Posted in: Repossession Repossession8-GTAV.png Posted in: Repossession Repossession9-GTAV.png Posted in: Repossession Back 1 ... 7 8 9 10 Next Retrieved from "http://gta.wikia.com/wiki/Category:Missions?oldid=832079" Categories: Gameplay Languages: Deutsch Magyar العربية


text:
Terry has won rave reviews on The Oprah Winfrey Show and the Late Show with David Letterman and has been called "one of the best entertainers in the world" by no less than American Idol's top judge, Simon Cowell. Live from Las Vegas, Terry Fator proves why he's the hottest ticket in town!
Bonus features include:
• "The Terry Fator Story," including audio commentary and a special live performance by The Commodores with Terry
• Behind-the-Scenes Featurette: Terry discusses the story behind each of his cast of characters
• Audio Commentary with Terry, writer Rick Kerns and director Mark Goffman
• Audio Commentary: Terry's puppets take over!
• Chapter 1 from Terry's autobiography, Who's The Dummy Now?
Meet the Puppets (Click for larger image)
Terry Fator & Puppets: Biographies
Terry Fator
It took ventriloquist, singer, comedian and celebrity impressionist Terry Fator 32 years to become an overnight sensation when he won the hearts of American and was selected America's Got Talent 2007 $1 million dollar prize winner on NBC-TV. His key decision to blend those incredible skills with his amazing ability to mimic famous singers won over the judges and millions of fans who voted for him.
Winston "The Impersonating Turtle"
One of the original members of Terry's cast, Winston the impersonating turtle has wowed audiences with his impersonation of Kermit the Frog perfectly and then shifting to an awe inspiring rendition of Roy Orbison. Winston is one of Terry's favorites and fittingly closes most shows with Terry beside him (where else would he be).
"The Lovely" Emma Taylor
This lovely lady has been with Terry from the beginning. Her unassuming appearance and quiet demeanor make her a welcome change from the rest of Terry's colorful and flamboyant cast. That is until she does what she does best, sing – and, man, can she belt it out! She blew the judges away in her appearance on America's Got Talent and has not looked back since.
Walter T. Airedale "The Country Man"
Walter T. Airedale is the self proclaimed "greatest country singer in the world." As anyone who has heard him perform would agree, Walter T. Airedale indeed has one of the most unique and charismatic personalities on the country music scene today. His magnificent renditions leave women in the audience screaming for more. Talented, tough, sexy and a definite ladies man make Walter a hit from coast to coast. He truly is a legend.
Julius "The Soul Singer"
One of the great additions to Terry's cast of entertainers is Julius, the greatest soul singer to ever hit Las Vegas! His smooth ballads, clever wit and flawless renditions are some of the best in the industry. From old to new, Julius has got it all. On an appearance with Oprah Winfrey, Julius brought the house down!
Maynard Tompkins "The Elvis Impersonator"
Maynard Tompkins is the self proclaimed "Greatest Elvis Impersonator in the World." The only problem is that Maynard doesn't seem to know any songs from the King. He is however a crowd favorite with his stunning outfits and smooth style with the exception of a slight stutter. The interaction between Maynard and Terry is priceless on stage. Maynard is the hope of every Elvis look-a-like in the country.
Dougie Scott Walker "The Rocker"
Dougie is the life of the show for everyone attending that had anything to do with the 60's. A natural born rocker Dougie loves AC/DC, Guns 'N' Roses, Skynyrd and any group that really rocked those years. Suffering from occasional flashbacks and not afraid to show it, Dougie is one of the most colorful and outspoken characters in Terry's show…and a total dude!


text:
Reviewed By Ron S (Sammamish, WA) Reviewed for a 1997 GMC Safari —5/13/2016 4:55 PM
One word...Awesome!
Reviewed By Michael E (Milwaukee, WI) Reviewed for a 2005 GMC Yukon XL —5/11/2016 8:41 PM
I just have to say I really like my transporter cargo box. I did have to figure some of the instructions out with washers but all in all easy to put together. I put it on the back of a yukon to put together and then tested to see how it worked. It hinged down nicely and locked to open the tailgate. I also drove with it on and never new it was back there. On the Yukon it's below the glass so you don't even see it. I did ultimately buy it for the back of a camper.Havent used it yet.
Reviewed By Danny Y (Cupertino, CA) Reviewed for a 2011 Mercedes-Benz GLK-Class —7/15/2016 4:20 PM
Box is light weight and easy to install onto the cross bar. It may take a little jiggle to close and lock the box if you are trying to stuff beyond its height limit. The interior locking mechanisms need to be free from stuff around them so it will lock more smoothly. But overall, it is a good box once you get the hang of it. Only wish the box could be just a little stiffer structurally which is the reason for the 4 star. Would recommend to friends.


text: 27 Ways the Sports World Changed Since the Miami Heat's Streak Began By Ralph Warner, Tim Pastore Share Tweet 0 Michael Jordan Turned 50 He's old and still competitve AF. Just ask Bron Bron. Source Watch Now Tags: Lists, Lebron James, Miami Heat, NBA Like Follow Chat SIGN UP FOR OUR NEWSLETTER Enter Show Comments


text:
Reading mode: Light Dark
Just talked with a ...
Started Sep 14, 2010 | Discussions thread
Shop cameras & lenses ▾
iteotwawki • Junior Member • Posts: 39
Just talked with a ...
Sep 14, 2010
Sales Rep at Samy's Camera in Los Angeles and we were talking about the HD video capabilities of the D3s. We were discussing the possibility of Nikon releasing a new pro body with 1080p considering that the D3100 has this capability. That and the fact that the D3s is getting hard to come by. Every store I called says the camera is backordered with only a few stores having any inventory.
What do you think? D3sx or D700s with 1080p and a few more bells and whistles?
iteotwawki's gear list:iteotwawki's gear list
Canon EOS-1D Mark IV
Reply to thread Reply with quote Complain
|Post (hide subjects)
|Posted by
|Sep 14, 2010
|Sep 14, 2010
|Sep 14, 2010
|Sep 14, 2010
|Sep 14, 2010
|Sep 14, 2010
|Sep 14, 2010
|Sep 14, 2010
|Sep 15, 2010
|Sep 15, 2010
|Sep 15, 2010
|Sep 16, 2010
|Sep 17, 2010
Keyboard shortcuts:
FForum PPrevious NNext WNext unread UUpvote SSubscribe RReply QQuote BBookmark MMy threads
Color scheme? Blue / Yellow
Latest reviews
Finished challenges
Most popular cameras
In-depth testingLatest Camera ReviewsBeyond the studio testsFeature Articles and VideosPIX VideosTalks, demos and panels689The Canon that canCanon EOS 80D Review364Touchscreen street shooterFujifilm X70 Review2136Upwardly mobileSony a6300 Review324Power ZoomPanasonic Lumix ZS100/TZ100 Review2478Retro through-and-throughFujifilm X-Pro2 Review
Top threads in this forum
Most bookmarked in this forum
Top posters in this forum
Follow us
All content, design, and layout are Copyright © 1998 - 2016 Digital Photography Review All Rights Reserved. Reproduction in whole or part in any form or medium without specific written permission is prohibited.


text:
Li is for Life: Lithium Brine Economics - Lithium and Potash tnr.v, lmr.v, rm.v, sqm 0 comments
Argentina & Mining 101:
Lithium & Potash which is more important in a brine? SQM Lithium breakdown
It seems like there is a phase of acquisition again in the market.
It's no coincidence that many of the projects in Argentina have been snapped up - most of which are public companies.International Lithium's core asset - the Mariana lithium brine, according to their presentation seems a negligible distance away from the largest lithium producer in the world.What makes this project so attractive is it's production capability of both lithium & potash.YES Potash - that elusive fertilizer component which is increasingly sought-after because of the primal need of people - food.Research all point to less and less arable (land that can grow crops) land, despite growing population size.Basically - either we all eat less, or we have to find ways to grow more with less land.Enter the modern fertilizer. The recent BHP Billiton attempted acquisition of Potash Corp is in line with the same expectation, that more mouths to feed = more food needed.
Though most people in the lithium sector think of SQM as a major lithium producer - bulk of their revenue actually comes from potash and plant nutritions.
Taken directly from SQM website for earnings year to date (YTD)http://www.sqm.com/pdf/Investors/PressReleases/en/SQM-PR_20101123-EN_0237.pdf
To make it easier for you - I've summarized it in a pie chart for you. Less than 10% of SQM's revenues come from lithium.I'll say it again - less than 10%.While the margins are far higher than their other lines of business - their main focus is on chemical products based around Potassium.Santiago, Chile, November 23, 2010.-Sociedad Química y Minera de Chile S.A. (SQM) (NYSE: SQM; Santiago Stock Exchange: SQM-B, SQM-A) Revenues totaled US$1,324.7 million for the first nine months, representing an increase of 25.9% over the US$1,052.2 million reported in the same period of 2009.Segment AnalysisSpecialty Plant Nutrition (NYSE:SPN)Revenues from our SPN business line for the first nine months of 2010 totaled US$452.5 million, 13.0% higher than the US$400.3 million recorded for the same period in 2009.Iodine and DerivativesRevenues from sales of iodine and derivatives during the first nine months of 2010 totaled US$241.8 million, an increase of 72.4% with respect to the US$140.3 million reported for the first nine months of 2009.Lithium and DerivativesRevenues for lithium and derivatives totaled US$114.3 million during the first nine months of 2010, an increase of 35.4% with respect to the US$84.4 million recorded for the first nine months of 2009.Industrial ChemicalsIndustrial Chemicals revenues for the first nine months of 2010 reached US$109.5 million, 35.3% higher than the US$80.9 million recorded for the same period of the previous year.Potassium Chloride & Potassium Sulfate (MOP & SOP)Potassium Chloride and Potassium Sulfate revenues for the first nine months of 2010 totaled US$356.8 million, a 24.3% increase with respect to the first nine months of 2009, when revenues amounted to US$287.1 millionOther Commodity FertilizersRevenues from sales of other commodity fertilizers and other income reached US$49.8 million in the first nine months of the year, down from US$59.1 million for the same period of the previous year.Salar brines are located in the nucleus of the Salar de Atacama. They contain the greatest lithium and potassium concentrations ever known, in addition to considerable sulphate and boron concentrations. From this natural resource lithium carbonate, potassium chloride, potassium sulphate, boric acid and magnesium chloride are produced.The Salar de Atacama is a source of underground salar brines, formed through natural leaching from the Andes Mountains: throughout time, diverse minerals found under the salt surface crust have descended from the mountains, accumulating in increasing concentrations.Together with high concentrations of salar brines, the Salar de Atacama has a series of advantages: it enables low processing costs due to its reduced magnesium content; it has higher evaporation rates than other salt plains in the world and it is able to operate all year long due to the privileged weather conditions that favour it.PROCESSSalar brines are pumped from beneath the saline crust in two different areas of the salar. In one of them, extracted salar brines contain unprecedented concentration levels of potassium and lithium. In the other, salar brines obtained contain high concentrations of sulphate and boron.After extraction, salar brines are located in SQM's solar evaporation ponds that cover 1,700 hectares approximately. Atacama Desert is the driest place on earth, with a solar evaporation index of 3,200 millimetres and average precipitations of only 15 millimetres per year. This results in an extremely efficient previous process of solar energy concentration.From the resulting solutions and after a series of processes, SQM produces potassium chloride, lithium carbonate, potassium sulphate, boric acid and magnesium chloride.What makes ILC so attractive then?
One of the highest potash values outside of Atacama. That's what.
Given that SQM does most of their revenue on potash-potassium related chemicals - would you rather have higher Lithium or Potassium? FYI - most of the other lithium brines don't have nearly as potash.
We are long TNR and through that, ILC. Based on what we observe with SQM, this seems like a sound logic especially with ILC's fantastic potash values.
We have not verified the data presented in this article.Please, do not forget, that we own stocks we are writing about and have position in these companies. We are not providing any investment advise on this blog and there is no solicitation to buy or sell any particular company here. Always consult with your qualified financial adviser before making any investment decisions.Back To Sufiy's Instablog HomePage »
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.Full index of posts »
TNR Gold And McEwen Mining Agree To Convert TNR's Back In Right To A NSR On The Los... $ABX, $ILHMF, $TRRXF http://seekingalpha.com/p/20a35 Oct 17, 2014
Rob McEwen Live On Gold, Silver And Los Azules Copper Potential Value Based On... $ABX, $ILHMF, $TRRXF http://seekingalpha.com/p/1xt89 Sep 12, 2014
Acquisitions Signal A Turning Market For Miners. Canadian Junior TNR Gold Holds... $ABX, $ILHMF, $TRRXF http://seekingalpha.com/p/1ww1t Aug 29, 2014
Latest Comments
- pablox on Why Other Countries Aren't Fracking - U.S. Gas Bonanza Slow To Spread Globally fracking is the countdown of mankind on earth
- pablox on Why Other Countries Aren't Fracking - U.S. Gas Bonanza Slow To Spread Globally fracking is the final countdown of mankind on e...
- DrAmit on Powered By Lithium: Elon Musk - Tesla Gets Infinite Mile Warranty. $TSLA $ILC.v $TNR.v $LIT well written. I see the technology company goin...
- melissabrittany on Powered By Lithium: Tesla Vs. BMW: Battling For Electric Car Supremacy TSLA, LIT, ILC.v, TNR.v, RM.v BMW's latest electric car model can pose a seri...
- Anyoption on US Dollar Meltdown - Will Gold Start To Move Finally Up Now? GLD GDX TNR.v MUX NG ABX Gold also has some good backing from the Ukrain...
- Deeptanwar on Lithium Catalyst: LG Chem CEO Says Mulls Electric Car Battery Plant In China ILC.v TNR.v LIT TSLA This helps lot more for new electric car batter...
Most Commented
- BNN: Los Azules: Rob McEwen on U.S. Gold and Minera Andes Proposed Merger and its valuation tnr.v, ilc.v, mai.to, tck, cuu.v, czx.v, lun.to, bwr.to, cs.to, imn.to, ncu.to, tko.to, wrn.to, qux.to, bls.to, bhp, fcx ( Comments)
- International Lithium Newsletter ILC.v TNR.v LIT ( Comments)
- TNR Gold: Los Azules Litigation: U.S. Gold, Minera Andes CEO urges holders to approve merger mai, uxg, ilc.v, tnr.v, czx.v, rm.v, lmr.v, abn.v, asm.v, btt.v, bva.v, bvg.v, epz.v, fst.v, gbn.v, hao.v, jnn.v, ks.v, ktn.v, kxm.v, mgn, mxr.v, rvm.to, svb, ura ( Comments)
- Lithium Jolt: DBM Energy: This Breakthrough Will Soon Slash EV Prices Drastically ilc.v, tnr.v, czx.v, rm.v, lmr.v, abn.v, asm.v, btt.v, bva.v, bvg.v, epz.v, fst.v, gbn.v, hao.v, jnn.v, ks.v, ktn.v, kxm.v, mgn, mxr.v, rvm.to, svb, ura.v, nup.ax, srz.ax, u ( Comments)
- Lithium Catalyst: Apple Electric ICar Coming From Tesla? ILC.v TNR.v AAPL TSLA ( Comments)
- TNR Gold And McEwen Mining Agree To Convert TNR's Back In Right To A NSR On The Los... $ABX, $ILHMF, $TRRXF http://seekingalpha.com/p/20a35
Instablogs are Seeking Alpha's free blogging platform customized for finance, with instant set up and exposure to millions of readers interested in the financial markets. Publish your own instablog in minutes.


text:
The products are first rate and the promptness in which I received the order was wonderful. Price is better than shopping at local stores if you are a VIP member.
More Testimonials »
Aquash Water Brush
From $4.84
Clic Eraser
From $1.24
ClicEraser Colors
From $3.15
Color Brush
Up to 35% Off
Color Pens
From $0.74
Colored Lead Refills
From $1.27
Colored Pencil Assortments
From $2.85
From $5.99
EnerGel Alloy RT Gel Pen
From $0.90
EnerGel Gel Ink Ballpoint Pens
From $1.49
Eraser Refills
From $1.07
Fabric Gel Roller Pens
From $1.99


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Rahul Akolkar" <rahul.akol...@gmail.com>
|Re: [all][scxml] Coberta dependency
|Tue, 27 Jun 2006 07:49:14 GMT
On 6/27/06, Phil Steitz <firstname.lastname@example.com> wrote: > In order for the nightlies to work and to avoid people having to > manually install the plugin, we should add the coberta dependency > explicity in the poms for the components that use this plugin. Any > objections to my fixing this for [scml] and others that use the report > but don't declare the dependency? > <snip/> Please, and sorry for the trouble (I don't like the default m1 dependencies page, partly why I hadn't added some site dependencies -- but I don't think I will be doing anything about it anytime soon). Should the comment indicate that it is part of the "site" goal? Many thanks for your help in reviving the nightlies. -Rahul > <dependency> > <groupId>maven-plugins</groupId> > <artifactId>maven-cobertura-plugin</artifactId> > <version>1.1.1</version> > <url>http://maven-plugins.sourceforge.net/maven-cobertura-plugin/</url> > <type>plugin</type> > <properties> > <scope>test</scope> > <comment> > Required only for generating test coverage reports. > </comment> > </properties> > </dependency> > > Phil > > --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
|View raw message


text:
you are viewing a single comment's thread.view the rest of the posts
Take my word MARQUEE results for c-MET+ 2nd-line patients will be very good. Why?
- Pucci mentioned that PFS was very good but mOS was very poor
- Pucci also said that 200+ patients were still alive and getting Tiva. Remember that the previous Tiva Ph2 in NSCLC and historical NSCLC indicate that these 2nd-line NSCLC patients have PFS `2 months and OS~7 months. This means that 40% of MARQUEE patients who got Tiva are alive & well and their disease did not progress after more than 8+ months after getting the Tiva treatment. Again, most of these patients supposed to be dead by now but they are still alive without disease progression. So, these patients will be alive for ~12 months. This is what the best NSCLC drugs can do for the 1st-line patients.
Tiva works in NSCLC for c-MET+ patients. MARQUEE trial was poorly designed targeting the wrong patient population. However, there are plenty of c-MET+ patients to show and to prove the Tiva efficacy in this NSCLC subgroup.
Pharma..thank you for the post and continued insight. I have been a long time investor in ARQL and disappointed by the news obviously, but I tend to agree with your analysis as far as the drug needing to be targeted at c-MET+ population. The failure of the MARQUEE trial is not inconsistent with this requirement and therefore the investment continues to make sense to me. Even though that means we are working with a smaller population and therefore a smaller market potential, I would think that success in 1 indication for a c-Met expressed population would get us back to the $6-10 range. If you believe that, this would be a perfect opportunity to lower the cost basis. I'm not one to throw good money after bad, but someone was thinking the same the other day when we were up 20% off the bottom.
I am a scientist and a good one. I know how to analyze data.
Let us review the facts/results:
- MARQUEE is a 1,000 pts trial. 500 pts got placebo and 500 pts got Tiva.
- If there was 50/50 c-MET+ and c-MET- patients split then only ~ 250 c-MET+ pts got Tiva
- As of 10.02.12, 200 pts were still getting Tiva. This is 40% of all ITT pts and ~75% of c-MET+ pts
- c-MET- pts don't respond to Tiva and live ~6-8 months
- c-MET+ placebo pts live only ~3.8 months (Roche MetMab Ph2 data)
- MARQUEE has at least 60%+ of its c-MET+ pts who are still alive after 7-8 months without disease progression
- NSCLC market is huge. It is larger than prostate, CRC, and breast cancer markets combined.
If Pucci is ready to leave NSCLC where Tiva works for 50% of all pts then he is an incompetent idiot! Then ARQL must be sold to a company capable of running clinical trials and helping to so many NSCLC pts.
Greetings, Pharma
Accordingly to the government clinical trials website, there are almost 30 trials of Tiva by ARQL and major medical centers and NCI. This shows that medical research community gives much more credit to Tiva than WallStreet criminals.
If one look at Roche NSCLC Ph2, they used almost 4-5 ways to measure c-MET value. This is why Roche Ph3 is moving slowly. Just way to measure c-MET is still an open issue.
Two more things. MARQUEE pts who are still well and getting Tiva are the people who hold the key to c-MET inhibitors enigma since they have something (some biomarker) telling who are and who are not benefiting from Tiva.
All Tiva trials will be going forward will that c-MET pts will be tested for c-MET.
About Roche. They tested MetMab on very few NSCLC patients. So, they don't know for sure that c-MET+ is the right indicator. Otherwise, they could enroll and complete their Ph3 trial in less than 2 years.
major strategic error. in fairness, that's with benefit of hindsight. Now metmab has inside track for nsclc and we go from being maybe 18 months ahead to basically being sidelined for this indication or best case 18 months behind. Now we just have to wait with fingers crossed for CRC.
You are incorrect.
You don't know that any drug is working before it has been proven in clinical trial. Otherwise, there would not be any need for clinical trials and there would not be so many failures in Ph3 by the best and brightest. There is no any prove that Metmab will work. Roche tested less than 60 patients. Many patients left the trial due to toxicity and at their doctor advice. MetMab was absolutely terrible in c-MET- patients.
This is the pharmaceutical business. This is why there are so many similar but different statins, antibiotics, diabetics, etc., drugs.
my point is, again with benefit of hindsight, would have been better to focus on cmet+ rather than broader population...I recognize pointless to speculate but no denying now marquee was poorly designed. Roche is focusing on cmet high pop becauase basically they had no choice...neg- effect on broader population ...obviously no guarantee they will succeed either with cmet+. mention of amgen interesting...they're now testing a cmet drug in gastric.
agreed re NCI trials.also sorafenib+tiva for melanoma ph1 looked good, with small numbers admittedly. Going back to your cmet+/NSCLC comments: do you know if the ph2 kras mutant trial has been stratified by cmet status? If so, maybe that's another strong avenue back to ph3 in NSCLC, this time focused on kras mutant and cmet+...is that a stretch at this point?


text:
- You'll save an extra 5% on Books purchased from Amazon.ca, now through July 29th. No code necessary, discount applied at checkout. Here's how (restrictions apply)
Learn more
Football Now! Paperback – Sep 17 2009
Amazon Price
|New from
|Used from
Paperback, Bargain Price
"Please retry"
Special Offers and Product Promotions
No Kindle device required. Download one of the Free Kindle apps to start reading Kindle books on your smartphone, tablet, and computer.
Getting the download link through email is temporarily not available. Please check back later.
To get the free app, enter your mobile phone number.
I'd like to read this book on Kindle
Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App.
Product Details
Would you like to update product info, give feedback on images, or tell us about a lower price?
Product Description
About the Author
Mike Leonetti is the author of many sports books, including the first edition of Football Now!
John Iaboni is a sportswriter and was coauthor of the first edition of Football Now!
Excerpt. © Reprinted by permission. All rights reserved.
Football Now! is the story of how during a complex time, some things never change. Playing NFL football can be financially rewarding, but you can't buy a championship. Winning a Super Bowl is still defined by the principles of hard work, discipline and sportsmanship. That was proved by the 2008 Pirrsburgh Steelers, who romped their way to an unprecedented sixth Super Bowl victory, the second in four years, with timely offense and the league's best defense -- the Steel Curtain reborn!
The march to six NFL titles in Pittsburgh has been orchestrated by coaching legends the likes of Chuck Noll and Bill Cowher, and now the fresh-faced Mike Tomlin, who at 36 became the youngest coach ever to win the Lombardi Trophy. His era is one not defined by chalkboard plays and X's and O's, but by high-tech tools that instantly provide benches with snapshots of plays that happened only seconds before. For Tomlin, and all those who have come before him and those who will follow in his footsteps, instilling his team with the will to win is, and always will be, the hardest part of the job.
Football Now! is the story of aging superstars showing their magic once more, like Tony Gonzalez, Hines Ward and Kurt Warner, and a new wave of stars whose time has arrived, such as Adrian Peterson, Larry Fitzgerald and Matt Ryan. Covered in these pages are stories about great plays and misplays, euphoria and dejection, blessed lives and troubled times; there are more than a few NFLers who have had to cast aside tough upbringings, and many who are having to deal with current off-field problems. Some overcome their difficulties while others are consumed by them. Sometimes, ultimately, the law is the agent that disciplines players, a troubling aspect of a league that is trying hard to ensure its role models are a positive influence on young fans.
Football Now! is the story of the fan. The in-game experience, whether live or through the media, is all encompassing: instant replays, analysis and camera angles covering every inch of the field are offered to observers at every moment. Today the NFL fan can be brought right into the huddle and can follow the ball from every conceivable angle, while capturing every crunching sound. It is the opportunity for every fan to be part of the stadium atmosphere without even being there!
In 2008, the NFL's marketing slogan was "Believe in Now," a sentiment echoed throughout the pages of Football Now! Today's NFL is packed with more capable superstars at every position than ever before. What follows is a glimpse into the story of Football Now! -- the careers of the 86 most influential players currently thrilling the football world.
Customer Reviews
|5 star
|4 star
|3 star
|2 star
|1 star


text:
|Home | About | Journals | Submit | Contact Us | Français
Currently, complete surgical resection is the only curative option for MTC. Previous work has shown the Notch pathway is a potent tumor suppressor in MTC and that Resveratrol activates the Notch pathway in carcinoid cancer, a related NE malignancy. In this study, we hypothesized that the effects observed on carcinoid cells could be extended to MTC.
MTC cells treated with varying doses of Resveratrol were assayed for viability using the MTT assay. Western blot analysis for Achaete-Scute Complex-Like 1 (ASCL1), chromogranin A (CgA), full-length and cleaved caspase 3, and poly-ADP ribose polymerase (PARP) was performed. Quantitative real-time PCR (qPCR) was used to measure relative mRNA expression.
Treatment with Resveratrol resulted in growth suppression and an increase in the cleavage of caspase-3 and PARP. A dose-dependent inhibition of ASCL1, a NE transcription factor, was observed at the protein and mRNA levels. Protein levels of CgA, a marker of hormone secretion, were also reduced after treatment with Resveratrol. A dose-dependent induction of Notch2 mRNA was observed using qPCR.
Resveratrol suppresses in vitro growth, likely through apoptosis, as demonstrated by cleavage of caspase-3 and PARP. Furthermore, Resveratrol decreased NE markers ASCL1 and chromogranin A. Induction of Notch2 mRNA suggests that this pathway may be central in the anti-MTC effects observed.
Medullary thyroid cancer (MTC) is derived from the calcitonin-producing parafollicular cells. This cancer accounts for 3–5% of thyroid cancer cases, though up to 14% of thyroid cancer deaths [1]. While early total thyoridectomy may be potentially curative for familial cases of MTC, sporadic MTC accounts for approximately 75% of cases. Surgical resection in the patient population, however, results in a recurrence rate of almost 50%. Additionally, patients with MTC suffer from debilitating endocrinopathies, related to excessive hormone secretion. The acidic glycopeptide chromogranin A (CgA) is typically co-secreted with these hormones and is used as a clinical marker of the disease [2–4]. Traditional adjunctive therapies, including chemotherapy and radiation, have shown limited efficacy, highlighting the need for novel therapeutic options [5–9].
While the role of Notch as an oncogene is well defined in breast, colorectal, prostate, and pancreatic adenocarcinoma, the Notch signaling pathway has been shown to have a paradoxical tumor suppressive role in neuroedocrine (NE) cancer types [10]. The Notch genes encode transmembrane receptors that regulate cellular differentiation, development, proliferation, and survival in many contexts. Upon binding of a ligand, a series of proteolytic cleavage steps occurs and the Notch Intracellular Domain (NICD) is released. This fragment translocates to the nucleus to activate a variety of target genes. In MTC cells, overexpression of Notch1 has been shown to inhibit growth and suppress Achaete-Scute Complex-Like 1 (ASCL1), an important helix-loop-helix transcription factor that regulates the NE cancer phenotype and has been correlated with poor prognosis in NE tumors [11]. ASLC1 has been shown to play a particularly important role in the thyroid as ASCL1 null mice fail to develop parafollicular cells [12,13]. Additionally, through ASCL1, Notch activation has been shown to suppress the levels of CgA [3,4].
Work by our group and others has validated the Notch pathway as a tumor suppressing pathway in MTC. Overexpression studies showed that Notch can suppress growth as well as ASCL1 expression. Pharmacologic induction of the Notch pathway was additionally shown to be a potent anti-MTC strategy in vitro [14–16]. This finding was subsequently confirmed in vivo [17]. Thus, drugs that target the Notch pathway are candidates for treatment of MTC.
Recently, our group developed a quantitative high throughput screen to identify Notch activating compounds. Pinchot et al. identified and validated Resveratrol as a potential Notch activator in gastrointestinal (GI) and pulmonary carcinoid cells. Resveratrol treatment was shown to inhibit the growth of carcinoid cells both in vitro and in vivo while suppressing the expression of ASCL1, CgA, and serotonin [18].
Resveratrol is a dietary polyphenol found in the skins of grapes and peanuts. A growing body of evidence suggests that Resveratrol may delay the onset of a variety of illnesses, including cancer, cardiovascular disease, and ischemic injuries [19]. High doses of Resveratrol in vivo did not reveal any harmful alterations in hematology, clinical chemistry, and organ histopathology [20]. Currently, Phase I/II clinical trials of Reveratrol are underway for the treatment of colorectal cancer and lymphoma [21].
In this study, we extended our analysis of Resveratrol from carcinoid to MTC. We show that Resveratrol suppresses growth, induces apoptosis, reduces ASCL1 and CgA expression, and increases Notch2 mRNA in MTC cells. These results are the first description of a Notch2 activator in MTC and suggest that Resveratrol may be a potential therapeutic option for MTC.
Human MTC (TT) cells were obtained from American Type Culture Collection (Manassas, VA) and maintained in RPMI 1640 (Invitrogen Life Technologies, Carlsbad, CA) supplemented with 16% FBS (Sigma), 100 IU/ml penicillin, and 100 μg/ml streptomycin in a humidified atmosphere of 5% CO2 in air at 37°C.
TT cell proliferation was measured using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay as previously described [13]. Cells were seeded in quadruplicate into 24-well plates and were incubated overnight to allow cell adhesion. After incubation, cells were treated 0–25 μM Resveratrol (Biomol International, Plymouth Meeting, PA). Treatment medium was changed every two days with new dilutions of drug. To perform the MTT assay, cells were washed with phosphate buffered saline (PBS) and incubated in 250 μl of serum-free RPMI 1640 containing 0.5 mg/ml MTT for 4 hours. After incubation, 750 μl of dimethyl sulfoxide (Fischer Scientific, Pittsburg, PA) was added to each well and mixed thoroughly. Absorbance at 540 nm was measured using a spectrophotometer (μQuant; Bio-Tek Instruments, Winooski, VT) and plotted as an average ± standard error of the mean (SEM).
TT cells were incubated overnight to allow cell adhesion. After incubation, cells were treated for 2 days with varying doses of Resveratrol. Total protein was harvested as previously described and quantified using the BCA Protein Assay Kit (Thermo Scientific, Waltham, MA) according to the manufacturer's instructions [13]. Denatured cellular extracts were resolved on a 10% SDS-PAGE gel, transferred onto nitrocellulose membranes (Bio-Rad Laboratories, Hercules, CA), and blocked in milk. Membranes were incubated overnight in primary antibodies with the following dilutions: 1:2000 for mammalian achaete scute homologue-1 (MASH1) for ASCL1 (BD PharMingen, San Diego, CA); 1:500 for chromogranin A (CgA) (Zymed Laboratories, San Francisco, CA); 1:1000 for poly-ADP ribose polymerase (PARP), caspase 3, and cleaved caspase 3 (cl-caspase 3) (Cell Signaling Technology, Beverly, Mass); and 1:10,000 for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Trevigen, Gaithersburg, MD). Membranes were then incubated in appropriate amounts of horseradish peroxidase conjugated goat anti-mouse or anti-rabbit antibody (Cell Signaling Technology), which were detected using Immun-star (Biorad) or Supersignal West Femto (Pierce Protein Research Products, Rockford, IL) kits, according to the manufacturer's instructions.
To quantify mRNA expression, we used quantitative real-time PCR (qPCR). Following treatment as above, total RNA was isolated using RNeasy Mini-kit (Qiagen, Valencia, CA) according to the manufacturer's instructions. The iScript cDNA Synthesis Kit (Bio-Rad) was used to synthesize cDNA using 2 μg of RNA per sample. Amplification and detection of PCR products were performed using iQ SYBR Green (Bio-Rad). The following PCR primer pairs were used: Notch2 (5′-TGTGACATAGCAGCCTCCAG-3′ and 5′-CAGGGGGCACTGACAGTAAT-3′), ASCL1 (5′ TCC CCC AAC TAC TCC AAC GAC 3′ and 5′ CCC TCC CAA CGC CAC TG 3′), and GAPDH (5′-ACCTGCCAAATATGATGAC-3′ and 5′-ACCTGGTGCTCAGTGTAG-3′). The following conditions were used for PCR amplification: 95°C for 3 min, 35 cycles of: 95° for 30 sec, 60° for 25 sec, 72° for 30 sec, followed by 95° for 1 min and 55° for 1 min. All PCR reactions were done in triplicate. Threshold cycles, Ct, were measured with iCycler Real-Time PCR Instrument and iCycler Software (Bio-Rad). Target gene expression levels were calculated using the ΔCt method with the formula 2(Ct(GAPDH) – Ct(target)), as described in Real-Time PCR Applications Guide (Bio-Rad). Expression in treatment groups was compared to control expression and plotted as an average ± SEM.
Statistical analysis was conducted using one-way analysis of variance (ANOVA) (SPSS software, version 10.0; SPSS Inc., Chicago, IL). A p value of less than 0.05 was considered significant.
Human MTC cells were treated for up to 6 days with increasing doses of Resveratrol and the MTT assay performed after 4 and 6 days of treatment. Compared to control, 25 μM, 50 μM, and 100 μM Resveratrol treatments for 4 days reduced growth by 5%, 8.9%, and 16.4%, respectively (P < 0.05). Treatment for 6 days resulted in a 19%, 38%, and 38% suppression of growth, respectively (P < 0.002) (Fig. 1).
To explore the mechanism of Resveratrol-induced growth suppression, we examined cleaved caspase 3 (cl-caspase 3) and cleaved poly-ADP ribose polymerase (cl-PARP) using Western blotting. The intrinsic and extrinsic apoptotic pathways both result in the cleavage of caspase 3, a critical protease that cleaves other apoptotic proteins such as poly-ADP ribose polymerase (PARP) to promote cell death. Thus, increased cleavage of caspase 3 and PARP suggest activation of apoptotic pathways [22–24]. We found that treatment with Resveratrol resulted in increased levels of both cl-caspase and cl-PARP. We also probed for full-length caspase 3 and PARP to verify that increased cl-caspase 3 and cl-PARP are attributable to proteolytic cleavage as opposed to an increase in total protein expression (Fig. 2).
We hypothesized that MTC growth inhibition would be associated with a change in NE markers. Thus, we examined levels of ASCL1 and CgA, both important markers of MTC [2–4,11]. Using Western blotting, we found that treatment of Resveratrol resulted in a dose-dependent reduction in CgA after 2 days of treatment (Fig. 3a). This finding is notable as CgA is co-secreated with bioactive hormones and used as a clinical marker of disease [2,4].
ASCL1 is transcription factor that is highly expressed in MTC and is strongly correlated with levels of CgA [13]. Furthermore, elevated ASCL1 protein is associated with poor prognosis in related neuroendocrine tumors (NETs) [24,25]. Thus, we performed western blot analysis for ASCL1 and found that Resveratrol suppressed ASCL1 protein levels after 2 days of treatment (Fig. 3a).
As ASCL1 suppression could occur at a number of levels, we performed qPCR for ASCL1 mRNA. Treatment of Resveratrol resulted in a dose-dependent inhibition of ASCL1 mRNA levels. Notably, a 70% reduction in ASCL1 mRNA levels was achieved with 100 μM treatment of Resveratrol (P < 0.001) (Fig. 3b).
Previously studies have attributed growth inhibition, induction of apoptosis, and suppression of MTC markers to Notch pathway activation [27]. Thus, we investigated the effects of Resveratrol on Notch2 mRNA expression, using qPCR. Treatment of Resveratrol resulted in a dose-dependent induction of Notch2 mRNA expression, with a significant 15-fold induction with the 100μM dose (P < 0.001) (Fig. 4). We also examined mRNA expression of other Notch isoforms and did not observe an induction (data not shown).
MTC is more difficult to treat and results in an increased mortality, compared to other forms of thyroid cancers [28]. In addition to a significant mortality rate, MTC is associated with debilitating symptoms such as dyspnea, dysphagia, diarrhea and flushing, associated with increased levels of hormone secretion and CgA [2,10]. Since surgery is the only curative option and traditional chemotherapy and radiation have limited efficacy, novel therapeutic approaches are necessary.
The Notch1 pathway has been validated as a tumor suppressor in MTC and has been shown to suppress ASCL1 and CgA expression [13]. Previous studies by our group and others have shown that targeting the Notch1 pathway in vitro and in vivo is a potential anti-MTC strategy [16,17]. Importantly, there appears to be significant overlap in the molecular targets of Notch1 and Notch2 [29]. Recently, Notch2 has been shown to induce many of the same biological effects as Notch1 in tumors of NE origin. In GI and pulmonary carcinoid cells, blocking Notch2 with small interfering RNA has been shown to rescue the Resveratrol-induced ASCL1 suppression [18]. We extend our group's previous work with Resveratrol in this paper by examining the effects of Resveratrol in MTC.
We show here that Resveratrol is able to significantly suppress the in vitro proliferation of MTC cells after just 4 days of treatment. Although the degree of growth suppression was modest, the effect on neuroendocrine markers was substantial. Additionally, we demonstrate an increased cleavage in apoptotic markers, suggesting that induction of apoptosis is the mechanism of growth inhibition. Western blot analysis revealed suppression of CgA, a marker of hormone secretion. These data suggest the Resveratrol is capable of suppressing bioactive hormones implicated in the debilitating edocrinopathies associated with MTC. We show that Resveratrol suppresses the protein and mRNA levels of ASCL1, a transcription factor that is critical in normal parafollicular cell development. ASCL1 is also correlated with poor prognosis in NETs and is a known mediator of CgA expression in MTC [1,4,10,12,13,30]. We additionally show that these changes are associated with an induction of Notch2, a tumor suppressing pathway in MTC.
In this study, we demonstrate the anti-MTC potential of Resveratrol and provide the first description of a pharmacologic Notch2-inducing compound in MTC. Resveratrol is a naturally occuring compound with an established safety profile [19–21]. Given the demonstrated efficacy in vitro and known in vivo safety profile, Resveratrol is worthy of additional pre-clinical investigation.
Grants: Department of Surgery T35 Short Term Training Grant DK 062709-0401 (MT), Howard Hughes Medical Institute (MRC), NIH – RO1 CA121115 (HC), NIH – RO1 CA109053 (HC), American College of Surgeons: George H. A. Clowes Jr. Memorial Research Career Development Award (HC), Carcinoid Cancer Foundation Research Award (HC)
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Puggle Quest
By Matthew Callahan
Open iTunes to buy and download apps.
Charlie the Puggle escaped from his home! How many treats can Charlie eat before he's caught?
* Help Charlie eat treats.
* Avoid the little boys who want him back.
* Earn extra lives every 3000 points.
* Watch out - they're getting faster!
iPhone Screenshots
View in iTunes
- Category: Games
- Released: 03 February 2011
- Version: 1.00
- Size: 3.1 MB
- Language: English
- Developer: Matthew Callahan
- © 2011 Matthew Callahan
Compatibility: Requires iOS 3.0 or later. Compatible with iPhone, iPad, and iPod touch.


text:
|Reviews for Family
| Mary Lou chapter 1 . 6/4/2014
Awesome story. Aside from a few grammatical errors, your story has a nice flow to it.
| Var Devonshire chapter 1 . 2/1/2014
Great story. I couldn't stop reading it! Well done. Var
| Guest chapter 1 . 9/3/2013
That was a great story. For Johnny to be in tears, wondering what he did wrong to make Roy mad at him and say terrible things to him, Roy must have put a world of hurt on him without laying a hand on him. SHAME ON ROY. Shame, shame everybody knows Roy's name. :(-
| Piscean6724 chapter 1 . 3/19/2012
I really enjoy stories that take me through a whole range of emotions. This one did just that. Thanks for sharing.
| jada951 chapter 1 . 12/15/2011
oh, I can't believe I didn't leave a review last time.
I really like your story and the relationships between characters, esp. Kel, Hank and John. Well crafted. I hope you might write more at some point.
thanks for sharing your story.
| ShadowWriter33 chapter 1 . 2/14/2011
Wow! What an amazing story. Normally I wouldn't get that into a story that had Roy and Johnny at odds with each other but you portrayed this so nicely. I loved the interaction between Kel and Johnny, the camping trip was perfect. I loved the way you depicted Cap as well. I was only sorry to see this wonderful story end. I would absolutely love to see a sequel someday, in which the rest of the crew discover Johnny's past and he and Roy get back to being the friends that they were. And to see Kel and Johnny's friendship progress, as well as everyone else finding out Jonny's true age. I always felt he looked too young in the show. Anyways if you ever decide to write a sequel I'll be the first one to read it. THis was a really great well written story. Good job!
God Bless,
| RampartNurse chapter 1 . 9/16/2010
Very touching story. :)
| Dreamer1985 chapter 1 . 9/11/2010
Glad he healed,and glad to see Dr. Bracket be the one to befriend him. Also, glad Roy recognized he had problems.
| trout1986 chapter 1 . 4/7/2010
This is a wonderful story. Thank you for sharing you gift.
| crokettsgirl chapter 1 . 7/13/2009
I found this story delightful. I love how you wrote it and the different plot. I love to wonder how Johnny's life was and you did put some nice thoughts in there and reasons for his feeling the way he does. And also I thought it really different to pair Kelly and John as friends, leaving Roy on the side line that caused the flash back. Excellent job. Sue
| Yum chapter 1 . 5/12/2009
Oh, I really like how you developed this dynamic between Kel and Johnny. We don't often get that. And I'm such a sucker for Hank! :)
| kremedic chapter 1 . 4/26/2009
This was a great story! I loved the character developement between Kel and Johnny. Keep writing!
| NickTonyK chapter 1 . 1/27/2009
Wow! Such a wonderfully moving story! Loved it a lot! I loved all the background you gave Johnny, really awesome! I hope you have more Johnny stories soon! Great job!
| CopperJoy chapter 1 . 1/24/2009
Great story! Loved it!
| mefrancene chapter 1 . 1/24/2009
I just wanted to say that I loved this story! It was truely a great read. Keep up the fantastic work! I'm looking forward to many more stories from you! :)


text:
Win prizes, kudos, recognition! Enter AOP prestigious Photography Awards before 7 August
This is a great pic and as sharp as a pin. Fantastic, you have my user award for this gem.
Sign In
You must be a member to leave a comment.
ePHOTOzine, the web's friendliest photography community.
Upload photos, chat with photographers, win prizes and much more.


text:
Cuisines and Dishes at Sam's Cafe:
- Deli Food
Jun 12 2016
Sana M. via Yelp
The gyros and shawarmas are great. The only difference is the bread they are served in, and the shawarma comes with pickles and tomatoes in it. Make sure to...read more
May 16 2016
Eric Y. via Yelp
Bomb. Great customer service and great greasy food. Gyro cheese fries. Mozzarella sticks. Heart attack. Shawarma all delicious.read more
Sep 16 2015
Jomi H. via Yelp
Went here one night after visiting the Cellar, had a Chicken Swarma, which was delicious and perfect for my late-night, after bar cravings! The man behind...read more
Powered by


text:
Enjoy a day of secret agent fun at the 2016 Corporate Kids Challenge!
Channel your inner Bond, Bourne or Mrs. Smith for this year's hardly-top-secret - but extremely entertaining - Ritchie Bros. Corporate Kids Challenge. All funds raised go to KidSport BC, a local organization that helps eliminate financial barriers to sport participation.
Assemble a team of 10-15 crack agents, and spend the day
- Meeting, greeting & competing with OLYMPIC ATHLETES & LOCAL CELEBRITIES
- Playing fun sports day activities, grooving to great tunes and more in this amazing team building event
- Participating in an exciting Ritchie Bros. LIVE CHARITY AUCTION
- Enjoying complementary lunch, dinner, refreshments and bragging rights
- Acting like a KID again
Sign up early, before this webpage self-destructs, and earn a competitive edge:
- 100 points if you sign up another team
- 50 points if you sign up before March 31
- 25 points if you sign up before May 31
Get mission-ready in 3 easy steps:
- Download the form to register a corporate team of 10–15 (mixed) secret agent-themed employees
- Submit a registration fee of $5,000 per team – ALL PROCEEDS go to KidSport BC, giving children in our community the chance to play organized sport
- Head down to Ritchie Bros.' head office in Burnaby on Saturday, September 10, 2016 for some fun!
Can't make it? Donate! Support the kids by donating goods and services to our exciting 'anything goes' auction.
Check out the pictures from 2015 event
Check out pictures from the 2015 event. And don't forget to follow @RBKidsChallenge and post your photos on Instagram and Twitter with the hashtag #CKC2015.
On behalf of KidSport BC, thanks again from Ritchie Bros. for your support and participation.
|@RBKidsChallenge on Instagram
|@RBKidsChallenge on Twitter
|Corporate Kids Challenge on Facebook
|Corporate Kids Challenge on YouTube
About the Corporate Kids Challenge
The Corporate Kids Challenge is an annual fundraising event presented by Ritchie Bros. Auctioneers at the company's headquarters in Burnaby, BC, Canada. All proceeds go to support KidSport BC. Corporate teams from the Greater Vancouver area team up with Olympians, professional athletes and local celebrities, and then face off in a series of fun sports day challenges (think tug-of-war). The day concludes with a live and silent charity auction featuring auction items donated by local companies and members of the business community. The first Corporate Kids Challenge was held in 2009.
About KidSport
All kids should be given the opportunity to develop healthy lifestyles, no matter the financial barriers that may exist. Staying physically active helps encourage children to maintain healthy habits throughout their whole lives. The challenges that come with playing sports also teach children valuable life lessons and skills including leadership, hard work, dedication and self-confidence.
KidSport was established in 1993 by Sport BC. KidSport is a community based sport-funding program that provides grants for children 18 and under to participate in a sport season of their choice. There are 40 community chapters in BC and over 175 chapters across Canada. With the help from dedicated corporate partners, KidSport works to fulfill its mission of eliminating the financial barriers to sport participation, 'So ALL Kids Can Play!' Learn more at KidSportCanada.ca.


text:
Live updates
Windows smashed at Blyth hairdressers
Police have launched an investigation after shop windows were smashed in two separate incidents at a hairdressers in Blyth.
Two men threw stones and smashed the windows of Cutter's hairdressers on Wright Street, between 8:40pm and 8:50pm on June 9.
A brick was then thrown through another window at the shop at 6:50pm on June 10.
The offenders ran off on both occasions.
Officers are appealing for witnesses and anyone who was in the area and who may have seen or heard anything suspicious is asked to Northumbria Police on 101.
- ITV Report
Police in charity abseil at Hexham Abbey
Officers from Northumbria Police have taken part in a charity abseil at Hexham AbbeyRead the full story ›
- ITV Report
PC uses day off to help victim of 'rogue traders'
A police officer has used his day off to help a woman who was tricked into paying hundreds of pounds for gardening.Read the full story ›
Man charged with possession of imitation firearm after Whickham stand-off
A man has been charged with possession of an imitation firearm after a stand-off in Whickham on Monday 20th June.
Armed police closed off nearby streets as they negotiated with the man who had locked himself in a house in Carnation Street in Whickham, Gateshead.
The incident ended at around 7.30pm after the man came out safely.
John Colin Mclean, 34, of Carnation Terrace in Whickham has been charged with possession of an imitation firearm with intent to cause fear.
He will appear at Gateshead Magistrates' Court on Wednesday 20th July.
- ITV Report
PC stops suicidal man from opening aeroplane door
A police officer has been nominated for a bravery award after risking his life when a man threatened to open a plane door mid-flight.Read the full story ›
Gateshead stand off with armed police ends
A stand off between armed police and a man who had locked himself in a house has ended.
The incident in Carnation Terrace in Whickham in Gateshead ended at around 7.30pm this evening. The man who had locked himself inside the address came out safely.
He was arrested by police and is now currently in custody.
Police said it had been a 'very difficult operation for our officers' and that enquiries are ongoing.
Whickham stand-off: Police say the man may have a weapon
Police remain at the scene and say they are speaking with the man and trying to get him to come out of the room safely.
Armed officers are in attendance as there is a possibility that the man may have a weapon inside the room with him.
A cordon has been put in place around the address to allow for emergency services to deal with this incident.
There is no risk to any members of the public at this time and our current priority is to get the man to come out of the room without causing any harm to himself or any of the officers inside the address.
Neighbours witness 'officers hiding in bushes holding guns' in Whickham
Neighbours have said there are around eight police cars and armed police officers as well as an ambulance at the scene.
A resident on the street, who does not want to be named, said:
I went out this morning to go and get my papers and the whole street was cordoned off.
I was not allowed to walk my usual way to the shop and so I had to take the long way round and they had to let me back onto the street through the police tape.
I think there is about seven or eight police men and cars and there are two officers hiding in the bushes holding guns.
It looks like it is the house at very the top of the street, the police are all stood around there waiting patiently for someone to come out.
I'm not really sure why this is happening.
A spokesperson for the North East Ambulance Service said:
We were called by the Police to an incident in Whickham.
Our Hazardous Area Response Team (HART) arrived on scene at 8.57am and a tactical on-call manager has now been despatched to support the team.
They are standing by but there is no news of casualties at present.
Whickham stand-off: Police cordon off streets as they continue to negotiate with man
Police are continuing to negotiate with a man who is thought to have locked himself in a house in Carnation Street in Whickham, Gateshead. Reporter Tom Sheldrick is providing updates from the scene
Major police presence, cordoning off nearby streets in Whickham, Gateshead - as armed police negotiate with man https://t.co/kzXIIPpvXy
Armed police dealing with 'incident' in Whickham
Northumbria Police are currently dealing with an incident in Whickham.
It's after a report this morning of a man locking himself inside a room at a house in Carnation Terrace.
Officers are currently at the scene speaking to the man and trying to get him out safely.
A small cordon is in place but we're being told there is no impact on the public or local roads at the moment.
Reporter Tom Sheldrick is there and has sent these images.


text:
2 dead after head-on collision in Phoenix
PHOENIX — Two drivers involved a head-on collision on Saturday have been declared dead, according to the Phoenix Police Department.
At approximately 6:40 p.m. on Nov. 23, Francisco Carranza, 50, was heading northbound on 83rd Avenue when he drove his 1999 Ford Expedition over the center line and collided head-on with a 2002 Chevrolet Tahoe at 83rd Avenue and Pomo Street.
The driver, 41-year-old Miriam Gonzalez, and Carranza both died at the scene.
While the investigation is on-going, Carranza was believed to be traveling at a high speed.
A third car also collided with the two vehicles, and the occupants were taken to a hospital with minor injuries.
Phoenix Police Sgt. Tommy Thompson said Carranza's Expedition had been involved in another collision just prior to the fatal one and had fled the scene.
Sponsored Articles
- Deciding when you need knee surgery
- Celebrating Fourth of July is much cooler in these AZ towns
- Top ten road trip bathrooms in America
- Six things causing a pain in your neck
- 5 things to make your summer move easier
- Three elements of a strong timeshare exit guarantee
- Stretches and exercises for carpal tunnel syndrome
- The best Major League ballparks have their own personality
- Comparing the best regular seasons: The '96 Bulls and '16 Warriors
- 3 Arizona road trips and the vehicles to get you there
- Colon cancer is preventable. Check these signs and symptoms to stay healthy.
- 6 of the biggest skin cancer myths
- Affordable small home makeover ideas
- Locals helping locals: 6 success stories you need to know about
- Sunscreen facts that could save your life
- 6 energy saving hacks for your home
- 5 tips for choosing a company to end your timeshare
- Overlooked water tips to save you money
- 5 of the most adored gentlemen in professional sports today
- The real danger of sitting at your desk
- Most surprising NBA playoff performances of the last 40 years
- 11 classic baseball movies you must see again
- Finally getting rid of fat: 3 methods that actually work
- 4 reasons cancer survivors should focus on food
- 5 spring cleaning spots everyone forgets
- 5 reasons to look forward to watching the D-backs this season
- Common virus attributed to spike in head and neck cancers
- 5 signs it's time to end your timeshare ownership
- 3 most overlooked ways to keep your home healthy
- 6 ways the air in your home could be making you sick


text:
Don't Ask Me No Questions
Theconservative blogs
in town have been a bit up in arms, rightly so, that aHouston Chronicle
editorial writer has donated $250 each to Barack Obama and Democratic county judge candidate David Mincberg.
Blogger Kevin Whited wrote to Steve Jetton, the Chron's reader rep, with some reasonable questions, among them where the editorial writer in question, Andrea Georgsson, would be participating in any Chron endorsements in the county judge race.
Upcoming Events
Houston Dynamo vs. Seattle Sounders FC
Wed., Aug. 24, 7:45pm
Houston Roller Derby
TicketsSat., Aug. 27, 7:00pm
AdvoCare Texas Kick Off Classic VIP Packages
Sat., Sep. 3, 12:00am
2016 Advocare Texas Kickoff
Sat., Sep. 3, 12:00am
Jetton wrote back that "We're looking into the situation."
Six days later, Whited wrote "It's been several days since my email about the 'situation' which I presume you found exactly as I described. Would it be possible for someone to answer the questions I raised?"
A day later he got this reply, in full: "A Chronicle editorial writer made political campaign contributions that she regrets. We've dealt with it internally and appreciate your concern."
That's not exactly responsive. As Whited replied: "I want to be sure I am reading this correctly as it is astonishing -- you as reader rep for the newspaper are refusing to answer legitimate substantive questions from a reader about this 'situation'?"
We've asked Jetton for a response; we'll post it when/if we get it.
-- Richard Connelly
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss Houston Press' biggest stories.
In Case You Missed It
Upcoming Events
WWE Presents NXT Live!
TicketsSat., Jul. 30, 7:30pm
Houston Texans
TicketsSun., Jul. 31, 8:55am
Houston Dynamo vs. San Jose Earthquakes
Sun., Jul. 31, 7:45pm
Houston Dynamo vs. Toronto FC
Sat., Aug. 13, 7:45pm
Popular Stories
Sponsor Content