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Sony NEX-6L/B Mirrorless Digital Camera with 16-50mm Power Zoom Lens and 3-Inch LED (Black) (OLD MODEL)
|$899.99 & FREE Shipping
Overall score: 78%
See review summary and sample images
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- Enter your model number to make sure this fits.
- 16MP APS-C CMOS sensor
- 10 frames per second continuous shooting
- Hybrid contrast and on-sensor phase detect AF
- 1080/60p HD video (AVCHD format)
- 3.0 inch articulated LCD with 921,000 dots
- Built-in 2,359,000 dot OLED viewfinder
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Technical Details
|Auto Focus Technology
|Autofocus Points
|Battery Average Life
|360 Photos
|Compatible Mountings
|Continuous Shooting Speed
|10 fps
|Digital Zoom
|Display Fixture Type
|Display Resolution Maximum
|Display Size
|3 inches
|Effective Still Resolution
|Expanded ISO Maximum
|Expanded ISO Minimum
|Exposure Control Type
|External Memory Included
|File Format
|JPEG (Exif 2.21), RAW (SRW), MPO
|Flash Memory Type
|SD/SDHC/SDXC/Memory Stick Pro Duo/ Pro-HG Duo
|Flash Modes Description
|Auto,Fill-in,Flash off,Slow synchronization
|Flash Sync Speed
|1/160 sec
|Flash Type
|Built-In Flash
|Flash Type
|Focus Description
|Contrast Detection
|Focus Type
|Includes Manual Focus
|Form Factor
|Rangefinder-style mirrorless
|HDMI Type
|Mini Type C
|ISO Range
|Auto, 100, 200, 400, 800, 1600, 3200, 6400, 12800, 25600
|Image Aspect Ratio
|3:2, 16:9
|Image Stabilization
|Image types
|Item Dimensions
|2.64 x 1.69 x 4.72 inches
|Item Display Weight
|0 pounds
|Item Weight
|0.76 pounds
|Lithium Battery Energy Content
|2 Watt Hours
|Lithium Battery Voltage
|2 Volts
|Lithium Battery Weight
|2 ounces
|Maximum Aperture
|Maximum Focal Length
|75 mm
|Maximum Shutter Speed
|1/4000 of a second
|Maximum horizontal resolution
|Multi, Center-weighted, Spot
|Minimum Aperture
|Minimum Focal Length
|28 mm
|Minimum Shutter Speed
|30 seconds
|Model Year
|Optical Sensor Resolution
|Optical Sensor Technology
|Optical Zoom
|Photo Filter Thread Size
|40.5 mm
|Photo Sensor Technology
|Processor Description
|Remote Control Description
|InfraRed (optional)
|Sensor Cleaning Method
|Charge protection coating on low-pass filter
|Shipping Weight
|1.85 pounds
|Style Name
|With 16-50mm Lens
|Supported Battery Types
|Lithium-Ion NP-FW50 rechargeable battery & charger
|Video Capture Format
|Video Capture Resolution
|Viewfinder Description
|2359000 dots
|Viewfinder Magnification
|Viewfinder Type
|Water Resistance Level
|Not Water Resistant
|Weather Resistance
Compare to Similar Items
This item: Sony NEX-6L/B Mirrorless Digital Camera with 16-50mm Power Zoom Lens and 3-Inch LED (Black) (OLD MODEL)
|Customer Rating
|FREE Shipping
|FREE Shipping
|FREE Shipping
|FREE Shipping
|Sold By
|Battery Description
|Lithium-Ion NP-FW50 rechargeable battery & charger
|NP-FW50 lithium-ion battery and USB charger
|NP-FW50 lithium-ion battery and USB charger
|NP-FW50 lithium-ion battery and USB charger
|Continuous Shooting Speed
|Flash Memory
|SD/SDHC/SDXC/Memory Stick Pro Duo/ Pro-HG Duo
|SD/ SDHC/SDXC, Memory Stick Pro Duo/ Pro-HG Duo
|SD/SDHC/SDXC/Memory Stick Pro Duo
|SD/ SDHC/SDXC, Memory Stick Pro Duo/ Pro-HG Duo
|Image Stabilization
|Autofocus Points
|Battery Average Life
|360 Photos
|420 Photos
|420 Photos
|400 Photos
|Display Resolution Maximum
|Expanded ISO Maximum
|Exposure Control Type
|Flash Dedication
|via Multi Interface Shoe
|Flash Sync Speed
|1/160 sec
|1/160 sec
|1/160 sec
|1/160 sec
|Focus Description
|Contrast Detection
|Hybrid autofocus (phase detection/contrast-detect AF)
|25-point contrast-detect
|Hybrid autofocus (phase detection/contrast-detect AF)
|HDMI type
|Mini Type C
|micro HDMI
|Image Aspect Ratio
|3:2, 16:9
|3:2, 16:9
|3:2, 16:9
|3:2, 16:9
|Iso Range
|Auto, 100, 200, 400, 800, 1600, 3200, 6400, 12800, 25600
|Auto, 100-25600 (51200 with Multi-Frame NR)
|Auto, 100 - 16000
|Auto, 100-25600
Please help us improve this feature. Tell us what you think of this feature.
Review summary from DPReview
The NEX-6 offers a highly attractive combination of excellent image quality, enthusiast-friendly ergonomics (including a mode dial--a first for the NEX-series), a 'real' hot shoe, an OLED electronic viewfinder, and useful features like Sweep Panorama and Auto HDR. That said, the NEX's user interface isn't for everyone. Having to download (and sometimes pay for) apps can be frustrating, and for best results you'll need to shoot raw.
Scoring is relative only to the other products in the same category.
Sample images from DPReview
Sample images for Sony Alpha NEX-6
Product Description
Product Description
From the Manufacturer
Raise your photography to the next level with NEX-6, a remarkably compact
interchangeable-lens camera loaded with big camera features. From the
distinctive dials on top to the large APS-C image sensor inside, you'll feel
that special sense of quality and performance that is a signature of DSLRs,
minus the bulk. Add ultra-fast phase-detection AF and Sony's superb XGA OLED
electronic viewfinder in addition to Full HD video recording at 60p and you have
a camera well equipped to take you on a unique photographic journey.
|Small Camera + Big Sensor = Amazing Pictures.
|Share and Save Instantly.
|Full HD Movies.
With 13 times the area of the typical point-and-shoot image sensor, APS-C sensor size makes the difference between "snapshots" and "photographs." This is the same HD sensor format that Sony builds into the full-sized α DSLRs.
Wi-Fi® capability – a first for Alpha digital cameras – lets users transfer photos directly to smartphones and tablets with the PlayMemories Mobile™ app. Wi-Fi allows for sharing, viewing and saving photos for expanded photo-shooting enjoyment.4
Capture HD Movies in your choice of super-smooth 60p, standard 60i or cinematic 24p, all at Full HD 1920x1080 resolution. AVCHD™ codec delivers stunning picture quality. MP4 codec offers smaller files for easier upload to the web.
incredible entertainment quality. Explore the full range of features and options below.
|16.1 MP APS-C size HD image sensor
The same sensor format that Sony builds into the full-sized α DSLRs. With 13 times the area of the typical point-and-shoot image sensor, APS-C sensor size makes the difference between "snapshots" and "photographs," delivering an exceptional combination of high resolution, high sensitivity and gorgeous, blurred backgrounds.
Fast Hybrid AF
Sony's advanced Fast Hybrid AF combines two technologies for outstanding performance: Phase detection auto focus for quick response that is ideal when tracking fast-moving subjects and contrast-detection auto focus for added precision. A perfect match that delivers optimal Auto Focus for fast, precise focusing in any scene.
Full HD Movies at 60p/60i/24p
Capture HD Movies in your choice of super-smooth 60p, standard 60i or cinematic 24p, all at Full HD 1920x1080 resolution.1 AVCHD™ codec delivers stunning picture quality. MP4 codec offers smaller files for easier upload to the web.
XGA Tru-Finder™ OLED
For size, speed and brightness even after sunset, the Tru-Finder™ OLED electronic viewfinder is a gem. This eye-level, through-the-lens, viewfinder begins with 2359K dots for amazing resolution and high contrast ratio for incredible depth. You can also see the results of camera adjustments in real time with superb color and detail.
Wi-Fi® Sharing
Wi-Fi® capability – a first for Alpha-series – lets users transfer photos directly to smartphones and tablets with the PlayMemories Mobile™ app. Wi-Fi capability allows for sharing, viewing and saving photos for expanded photo-shooting enjoyment. Photos can be easily transferred to smartphones and tablets, viewed on large screen TVs or saved to PC's.4
PlayMemories Camera Apps™
Supports PlayMemories Camera Apps™ service, the world's first application download service that lets users install new camera functions as needed.4
Advanced Control Dial
Mode control dial and Quick Navi assure quick an intuitive operation comparable to DSLR cameras Control dial, Fn (function) button and touch screen (including touch shutter function) combine to greatly facilitate operation and speed getting the shot.
Picture Effect mode
There are 7 types (11 variations) of picture effects to choose from: Posterization (Color), Posterization (B/W), Pop Color, Retro Photo, Partial Color(R), Partial Color(G), Partial Color(B), Partial Color(Y), High-key, High Contrast Monochrome, Toy Camera. Each is unique and each give you a new and exciting way to make your images and videos pop.
6-image layering
The camera leverages the large, APS-C image sensor and captures six images in a fraction of a second. The camera then combines the data from the 6 different images up to ISO 25600 to create a single image. This method is used to control blur in Anti-Motion Blur mode or to get cleaner, sharper nighttime pictures in Hand-held Twilight mode.
|Accepts Sony® E-mount lenses
Compatible with Sony's wide selection of E-mount series of smaller, lighter lenses designed specifically for α compact interchangeable lens cameras. Open up a world of endless creative options.
Photo Creativity Touch interface
The Photo Creativity touch interface enables you to easily enjoy the creative expression of SLR-quality digital imaging without the complicated settings. Changes can be easily made using the control dial with results seen in real time on the LCD. Settings include; Background Defocus, Brightness, Color, Vividness and most Picture Effects.
Auto Portrait Framing
Simply photograph a person and Auto Portrait Framing will save an additional, optimally framed image in portrait or landscape orientation. Combining Face Detection and By Pixel Super Resolution technologies with rule of thirds, Auto Portrait Framing provides beautifully composed and appealingly balanced full resolution portraits.
Clear Image Zoom
Utilizing Sony's exclusive By Pixel Super Resolution Technology, Clear Image Zoom increases the effective focal length of your lens up to 2x by digitally magnifying the center of your image with nearly imperceptible degradation. It virtually doubles the effective focal length of whatever lens you're using providing greater shooting flexibility.
Convenient USB charging
Easily recharge the camera via USB charging. Simply connect the bundled USB cable and recharge the battery without removing it from the camera, either via AC outlet or PC connection.
New Multi-Interface Shoe
Unlike conventional cameras, the NEX-6 features a newly developed Multi-Interface Shoe that dramatically expands compatibility with Handycam® accessories, thus raising the potential for photo/movie shooting.
Auto HDR built into camera
High Dynamic Range (HDR) photography captures more scene contrast than a single exposure can handle by combining the best highlight detail from one shot and the best shadow detail from another for one incredible shot. Handles severe backlighting and other high-contrast scenes. Captures in a split second. (Recommended for still subjects.)
Sweep Panorama™ Technology
Capture expansive landscapes automatically. Press the shutter, sweep vertically or horizontally. The camera does the rest, continuously shooting images and stitching them together. Up to 23 MP image size. Up to 202 degrees maximum sweep angle (18mm focal length).
Fast Auto Focus
Some cameras in this class are slow to focus. That can make you miss the shot on fast-moving subjects like sports and unpredictable subjects like pets and babies. Sony's fast Contrast Auto Focus system typically takes as little as 0.3 seconds and also offers continuous Auto Focus when shooting movies.
|Peaking AF display
The Peaking AF display makes precise manual focusing much easier by highlighting the edges that are in focus in your choice of three colors (white, red, or yellow). This is especially helpful during macro or portrait photography where your focal plane can make or break your shot.
Manual Focus Assist
Greatly magnifies the viewfinder image when you touch the focus ring, making it easy to get razor-sharp images. Works with E-mount lenses only.
Enhanced Tracking Focus
Tracking Focus continuously tracks a user-designated subject and is now more effective at tracking people. If the subject turns away from the camera, face-detection tracking automatically switches to subject tracking and continues tracking.
Face Detection technology
The camera can automatically detect up to eight individual faces and adjust focus, exposure, white balance and flash to help deliver crisp, properly lit images of family and friends. Can prioritize children or adults.
Smile Shutter™ technology
Captures a smile the moment it happens. Simply select the Smile Shutter™ mode and the camera takes the picture automatically. You can prioritize children or adults and adjust the smile sensitivity.
Dynamic Range Optimizer (DRO)
Improves results with backlit subjects and recovers details hidden in shadows. Settings include Auto, Level with a choice of five operating levels and Off.
Six Creative Style settings
Control how the camera processes your images with six finishing styles: Standard, Vivid, Portrait, Landscape, Sunset and B&W. You can even fine-tune contrast, saturation, and sharpness to your personal taste.
PhotoTV HD compatibility
Optimizes compatible BRAVIA® televisions for gorgeous display of digital pictures.3
Dual Format Media Card Slot
For cost-effective, convenient storage and sharing of your images, the camera accepts Memory Stick PRO Duo™/Memory Stick PRO-HG Duo™ and SD/SDHC media (Class 4 or higher recommended), (Memory card is required, all are sold separately).
Anti-Dust Technology
Dust on the image sensor leads to blemishes in the picture. To protect the sensor, Sony incorporates an advanced ultrasonic system, which effectively shakes dust off the sensor surface.
Sony Suggested Accessories
1. Records in up to 29 minutes segments.
2. Attaching Sony A-mount lens requires LA-EA1 (note: Autofocus available with SSM and SAM series lenses when using LA-EA1) or LA-EA2 adaptors (sold separately).
3. Requires compatible BRAVIA® HDTV and HDMI® cable sold separately.
4. Requires an active 802.11 Wi-Fi network (802.11n recommended) or PlayMemories Mobile™ app installed on compatible Android™ or iOS device.
PlayMemories camera apps require download with existing Sony Entertainment Network account. Download available in all countries/areas
where Sony Entertainment Network is available.
© 2012 Sony Electronics Inc. All rights reserved. Reproduction in whole or in part without written permission is prohibited. Sony is not responsible for typographical and photographic errors. Features and specifications are subject to change without notice.
Sony, BIONZ, BRAVIA, Exmor, InfoLITHIUM, Memory Stick, Memory Stick Duo, Memory Stick PRO Duo, Memory Stick PRO-HG Duo, PlayMemories Home, Smile Shutter, Stamina, Theatre Sync, Sweep Panorama, and the Sony make.believe logo are trademarks of Sony. AVCHD is a trademark of Panasonic Corporation and Sony Corporation. Microsoft, Windows, and Windows Vista are trademarks of Microsoft Corporation. Mac OS and iMovie are trademarks of Apple Computers, Inc. HDMI is a trademark of HDMI Licensing LLC. All other trademarks are trademarks of their respective owners.
InfoLITHIUM® M Series Rechargeable Battery
Lithium-Ion Rechargeable Battery
Read about our customers' top-rated cameras and lenses on our review pages: Compact System Cameras, Lenses
Customer Reviews
Top Customer Reviews
Even though I have a Canon 5D Mark II, a wonderful DSLR, its size and weight are a big deterrent to taking it with me routinely. So I wanted a camera designed in the spirit of the Rollei 35 - to fit in a coat pocket, have a sensor big enough to make 11 x 14 enlargements, have a zoom lens with a 24mm field of view, and a have a built-in viewfinder, not an add-on, and not just an LCD. Until now (11/2012) the options were the Sony NEX-7, upcoming Fuji X-E1 and the larger Olympus OM-D, all at $1300 or more.
I have now taken about 500 shots and the NEX-6 is close to perfect for my purposes - a digital reincarnation of the Rollei 35. But it won't be right for everyone.
The heart of the NEX-6 is an APS-C size sensor, the size in the vast majority of DSLRs. It's 1.5 times the size of a the "4/3rds" sensor found in similar Olympus and Panasonic cameras and 3 times the size of the sensor in Nikon 1 cameras. As a result, the image quality is excellent up to ISO 1600 and not bad up to ISO 6400. A new Sony kit lens gives a field of view equal to 24-75mm on a 35mm camera. The lens focuses quickly and collapses to a small size, so the camera fits in a coat pocket or the corner of a backpack. There are some complaints on Internet forums about the lens vignetting and about distortion at the wide end.Read more ›
I've had the NEX-6 for about 10 days now and I've been testing the OM-D for about 4 days now, so I feel pretty confident and ready to give my review:
What I really like about the NEX-6:
+ Great ISO (low light) performance. Better than the NEX7, and slightly better than the OM-D (this is due to a larger APS-C sensor than OM-D's Micro 4/3, and compared to the NEX-7, the NEX-6 has a lower MP count on this sensor, the NEX7 has more resolution, but images have considerably more noise at 1600 ISO and above).Read more ›
This is Sony's 8th NEX camera in just over two years. You can't say that they aren't serious about the camera line. The NEX 6 is an enthusiast's camera. It's for photographers who are looking for more manual controls than are available in the NEX 3 or 5 models. It has a similar 16 MP sensor to the others and the same very good image quality. You aren't gaining better picture quality in getting the 6 vs one of the NEX 3 or 5 models. So if you are moving up from a phone camera or a point and shoot, you might find one of the other models closer to what you are used to than the NEX 6.
On the other hand, if you are looking at the NEX 6 as second camera, or even as a replacement for a bigger one, the 6 is much more portable than a DSLR the extra dials and buttons on the NEX 6 will speed up camera mode and exposure changes. So, on to the specifics
The first yes is the inclusion of an electronic viewfinder (EVF), similar to the one in the NEX 7. That's a great inclusion and makes the 6 more versatile. It's seems similar to the NEX 7 EVF and the same pixel dimension. The EVF is sharp and clear. It works well on this size camera.
The second yes is the addition of a flash shoe, a real one that accepts all sorts of manual flashes. It's a change from the old reversed Minolta/Sony flash shoe, so if you have old Sony flashes you will need an adaptor. The newest Sony flashes are built the new flash shoe. The camera also has a built in flash, instead of the screw on model on my old NEX 5n.Read more ›
Customer Images
Most Recent Customer Reviews
I was a happy user of the NEX6 for almost 2 years, when I decided to replace it for the a6000. All I can say is that this camera was a joy to use and that always gave me really... Read morePublished 1 month ago by Victor Bastos
Great camera for a family with little experience in photography! Great pictures!Published 3 months ago by fadi alswaiti
Let me say that this is my first mirrorless camera, so I can't compare it to other similar cameras. I have not owned a DSLR either, so I can't compare this to a DSLR. Read morePublished 4 months ago by David Aikens
Awesome camera took about 100 pic's yester day the day I received the cameraPublished 6 months ago by bjsmarch
Love this camera!
I have been using this camera for quite a while now and I love everything about it. Read more
I ordered this camera a few months ago. Finally got a chance to use the camera today and it does not work. Takes black pictures. I want to return this piece of garbage.Published 6 months ago by Amazon Customer
My first venture into the mirror-less universe. Was good and still is.Published 6 months ago by Anurag Devanapally


text:
The complete results of the Washington Fair blue ribbon steer auction are published below.
Published are the names of the exhibitor, address, weight of the steer, price paid per pound, total price paid and the successful bidder.
You must login to view the full content on this page.
Or, use your linked account:

subset: commoncrawl


text:
If you have troubles since the update to WordPress 4.5 please read this post before opening a new thread.
I just tried to update through ftp to 1.7.1 with horrific results (http://dev.giulianacucinelli.com/). Both the child theme and the main one are totally messed up. Any clues?
Please try to re-upload all theme files. I'd suggest to use ftp to overwrite the existing files. You can also try to switch to another theme and to re-activate Enfold. This will trigger some additional functions/hooks which might be required to install the updated version properly.
The topic 'Enfold: update to 1.7.1 failed' is closed to new replies.


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From Publishers Weekly
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. --This text refers to an out of print or unavailable edition of this title.
`Collins's mid-Victorian novel is one of the first, and possibly still the greatest, of all literary thrillers.' The Irish Times --This text refers to an alternate Paperback edition.


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Scientific Forecaster Discussion
Area forecast discussion
National Weather Service Billings Montana
959 am MDT sun Jul 24 2016
A few weak thunderstorms have moved south and east of Powder River
and Carter counties this morning. Weak ridging in place today
will keep skies mostly clear and thunderstorms out of the
forecast. Temps will warm into the upper 80s to low 90s in the
afternoon with weak winds. Warmer and drier conditions anticipated
for Monday with a chance for afternoon thunderstorms. Walsh
Short term...valid for tdy and Mon...
Latest radar imagery continues to show a few showers and
thunderstorms moving through the far S and southeast zones at 07z. The
models hold onto this precipitation until 18z when the responsible
shortwave pulls east-southeast away from the area. Thus have added low pops
to the affected areas through 18z. Kept some low pops in the
southern portion of the NE bighorns after 18z with some energy
continuing to affect this area. Temperatures will range from the
mid 80s to lower 90s today. Went a shade below the blended
guidance based on mixing seen on the WRF BUFKIT. While humidities
will be only in the teens and 20s, winds will be light, mitigating
fire weather concerns.
Weak upper ridging will be over the area tonight with a dry
airmass so had no need for pops. 850 mb temperatures in the mid
20s c will support mins in the 50s to lower 60s. Heights remain
high on Mon., But shortwave energy returns to the area, with low-
level S to southeast flow over the east. Resulting precipitable waters climb
to an inch or more over the NE part of the area. MUCAPES on the
sref increase to 500-1000 j/kg over the area Mon into Mon. Night.
The highest convective available potential energy shift east late Mon. Night. Bulk effective shear
was not overly high...in the 30s. Models were in good agreement
in moving a cold front through the central zones by 12z Tuesday.
Based on the above, have spread slight chance to chance pops
across the area Mon. Afternoon, and continued these pops Mon.
Evening. Lingered slight chance pops ahead of the front over the
southeast zones late Mon. Night. Storm Prediction Center places the far east in a marginal risk
for severe storms Mon. Through Mon. Night where the highest convective available potential energy
and shear are forecast. Temperatures on Mon. Will be back in the
90s due to a warmer airmass and better mixing. Humidities will
continue to be low, but winds will be light. Arthur
Long term...valid for Tue...Wed...Thu...Fri...Sat...
A series of Pacific shortwaves will bring daily potential for
thunderstorms Tuesday through Thursday. Central Continental U.S. Ridge will
shift west and strengthen over the Great Basin by Thursday,
allowing for flow aloft to shift from zonal to northwesterly over
our region. Thus, Tuesday should be the warmest day followed by a
slight cooling trend Wednesday and Thursday. The cooler mid level
temps should allow for convection to develop a bit more
effectively, and some severe storms cannot ruled out in our east
where instability will be greatest. There could also be some
locally heavy rain in our east as the persistent easterly sfc flow
allows pwats to increase to around an inch if not a bit higher.
And of course, the anticipated increase in lightning activity
could result in additional fire starts.
Conditions should transition toward drier Friday as ridge begins
to build back in from the west. Warming trend will continue
Saturday, but monsoonal moisture may begin to wrap around Great
Basin ridge bringing a risk of higher-based thunderstorm activity
by next weekend.
As far as temps go, expect 90s Tuesday cooling to the mid or upper
80s by Thursday, then back to the 90s or perhaps near 100 degrees
next weekend. Models are in pretty good agreement with this
overall trend in temperatures as we move through the last week of
Dry weather with VFR flight conditions will prevail
through tonight...along with light winds. Bt
Preliminary point temp/pops...
Tdy Mon Tue Wed Thu Fri Sat
bil 088 061/095 063/095 064/091 062/087 060/088 062/094
1/u 02/T 22/T 22/T 23/T 32/T 21/u
lvm 086 051/093 053/095 054/090 054/087 050/089 052/094
0/u 03/T 22/T 22/T 23/T 32/T 22/T
hdn 090 058/097 061/096 061/093 059/089 056/089 059/095
1/u 02/T 22/T 22/T 23/T 32/T 21/u
mls 090 063/098 067/097 068/093 064/087 061/088 062/093
1/u 02/T 22/T 23/T 33/T 32/T 21/u
4bq 090 062/098 064/097 064/094 061/089 059/089 060/093
1/u 02/T 33/T 23/T 33/T 32/T 21/u
bhk 086 059/096 061/093 062/088 059/084 058/084 057/088
1/u 03/T 43/T 34/T 44/T 43/T 21/u
shr 088 055/096 057/096 057/093 057/088 054/090 054/094
Byz watches/warnings/advisories...
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text:
Groupwork 60" Table
by Turnstone
At A Glance:
Perfect for your own personal workspace or collaborative meeting place, the 60" wide Groupwork Desk provides smart design, good value and the solid performance you'll come to expect from Steelcase office furniture. Choose the depth and finish that works best for your space.
What's To Like:
If you really love straight lines and simplicity: this is your table. No clutter, no distracting "design features," just a sturdy table. The caster options and flip-top option make it a great choice for a training room or constantly-changing workplace.
What's Not to Like:
Let's see ... the Groupwork Table's legs will be difficult to attach if you don't have a drill. You can just use a screwdriver, if you have some serious oomph, but it'll be a task. (Note: we can't believe spellcheck recognized "oomph" as a word.)
The Bottom Line:
With a wide range of laminate choices, optional casters, and sturdy construction, the Groupwork Table is a great work table choice for offices, both home and workplace.
- 1-1/8" thick desktop with durable, low-pressure laminate finish
- Choose from 24" and 30" depths
- Also available are the Groupwork 48" wide desk and the 72" wide desk
- 3mm radius profiled edge banding for a smooth, sophisticated look
- Choose from standard T-Legs or optional post legs or flip-top caster legs
- If chosen, flip-top legs allow you to flip the desktop up for easy storage
- Casters are an option for any of the leg choices, to give you extra mobility
- Leg Height (without casters) is 27" h
- Optional modesty panel for a more private work environment
The Groupwork Table is also known by the following manufacturer item number: TS4TLR3060.
Materials & Measurements
Low-pressure laminate tabletop and edge banding. Powder-coated steel legs.
Overall Dimensions:
27.375" h x 60" w x 24" or 30" d (depending on selection)
Top Dimensions:
60" w x 24" or 30" d (depending on selection) x 1.125" thick
Modesty Panel Dimensions:
49.625" w x 9" h
About The Manufacturer
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Shipping & Delivery
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Shipping Service:
The default, free shipping service is Curbside. This means that your item will be delivered on a large commercial truck to your curb. In some cases, you may have to assist the driver in removing the item from the truck. Shipping upgrades are available and come highly recommended.
This item typically ships with 10 business days from the purchase date.
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If you have additional questions regarding Smart Furniture's policies in general, please see our FAQs page.
Product Q&A
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Q:Re the groupwork 30 x 60 fliptop table with casters, What color are the legs? Is there a choice? or only a choice with the desktop material?
thank you.Asked on 7/16/2011 by Anonymous
1 answer
A:The legs by default will be platinum metallic, but can come in other colors including: black, sand, arctic white, seagull, champagne metallic, sterling metallic, and midnight metallic. To see any of these swatches please email email@example.com and we will send them your way.Answered on 7/16/2011 by Melanie from Smart Furniture
Turnstone Groupwork Desks are backed by Steelcase's limited lifetime warranty.


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Ontario HIV and Substance Use Training Program
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- About The Ontario HIV & Substance Use Training Program (OHSUTP) provides training to substance use, mental health and allied social service providers across Ontario. We provide the most up-to-date information about the connections between HIV, Hepatitis C, substance use and mental health. In order to increase staff knowledge and to promote skills development, we combine the delivery of technical information with hearing from people with lived experience. OHSUTP services are typically free of charge. We are accredited with the Canadian Addiction Counsellors Certification Federation (CACCF) for continuing education credits.
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GREENWOOD BAPTIST CHURCH, 461 6th St. @ 7th Ave, Indoor Flea Market, SAT. AUGUST 13th 10AM-4PM. Handmade Jewelry, Books, Clothing, Baked Goods & More! New&Used. P. Brayboy 718.768.2488 x12
Sunday, July 24, 10:30AM-5PM. Ave U/West St (By Post Office, in Alleyway) Pool, Halloween Items, Monitor, Stuffed Animals, Kids Bikes, Clothes, Shoes, Sneakers, Picture Frames, Wall Paper, Radio and More!
FURNITURE LIQUIDATION New in Box w/warranty Bedrooms, Sofa's and Dining Up to 60% MSRP Call Now: 718-499-4499
BAY RIDGE MOVING/ ESTATE SALE!! SAT-SUN 7/23-7/24, 11AM-5PM. 580 Fort Hill Place (betwn Battery Ave & Dahlgren off 92nd St) Everything Must Go!! Furniture, Housewares, China, Vintage Clothing, Tools. 215-584-0188
GARAGE SALE Sun 7/24 & Sun 7/31 609 E 48th Street bet Beverly & Tilden Household items, camping & scuba diving equipment, hunting items & much more
Multi-Family Yard Sale Avenue L Between East 57th & East 58th, Sat. 8/6, rain date Sun 8/7 from 10:00am-4:00pm New and used items, School Supplies, Clothing, Tools, Toys & more.
MULTI-FAMILY YARD SALE: FRIDAY 7/22, SATURDAY 7/23, SUNDAY 7/24, 10AM-5PM 2021 Hendrickson St (Betwn S&T) Toiletries, Sports Gift Baskets/ Memorabilia, Housewares, Comics, Baseball Cards, Men's/ Women's Clothing/Shoes, Books, DVDs/CDs, MORE!!
Saturday, July 23 9AM-2PM. 8 Keen Court. Bklyn, NY (Between Lester Court & Cyrus Ave) Stereos, TVs, Electronic Games, Pet Supplies, Appliances, Furniture, Tools, Books and Much, Much More!
TAG SALE Sunday 7/24 from 11-5pm Moving! Everything has to go. Various antique & contemporary furniture, couches, tables, chairs, dresser, lamps, vintage outdoor garden furniture set.
BODY Work By Mike Master Reiki Professional Massage Shiatsu/ Foot Reflexology. Stress Relief & Relaxation. Certified. Bensonhurst Loc. 718-236-5861 917-292-6075
Large Panasonic Microwave convention. Perfect condition. Cost $5.00 Moving. $60.00 Firm 718-252-0638
New White & Chrome Medical Extended Bath Seat For Sale. $49 or best offer. 917-294-3207
Old Steamer Trunk For Sale, $99 or best offer. 917-294-3207
CASH FOR DIABETIC TEST STRIPS Up to $35/Box! Sealed & Unexpired. Payment Made SAME DAY. Highest Prices Paid!! Call JENNI Today! 800-413-3479 www.CashF
CASH FOR DIABETIC TEST STRIPS Up to $35/Box! Sealed & Unexpired. Payment Made SAME DAY. Highest Prices Paid!! Call Juley Today! 800-413-3479 www.CashF
MOVING SALE 1630 E 37th Street Bet Quentin Rd & Ave P Sat July 23rd 10am Dining room set, futon, TV wall unit, housewares, camping equipment & much more
Golf Set- Precise RX450 complete with large apparel pocket for storage & ball pocket. $289/neg. Contact gpcro
Magnificent Custom Built Center Hall Colonial in Desirable High Rock, Staten Island. Features: Open Floor plan Layout, Picturesque Secluded Backyard which Borders, High Rock Park with 13,000 Sqft of Land. Offered at $1.1 Mil. Titan Home Realty: 917-612-1458
TOTTENVILLE, S.I. NEW CONSTRUCTION 2 Family Det Home, Oversized Kitchen w/ Granite Tops & S.S Appliances, Fireplace, Hdwd Floors, 4 Bdrms, 2 Full Baths, One 3/4 Bath & One Half Bath. A Must See!! Call 718-744-5206 For More Information Shapiro Realty
WEST BRIGHTON Charming vintage 18th century home with six bedrooms a must see on a 90 x100 Ask $795k Debra Guzzo Exit Realty Liberty Homes Office: 718-966-3600 Cell: 646-387-0205
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Tracy Sutton is no expert on mold, but she knows it's a bad thing to have growing in her house on North Burghley Avenue in Ventnor Heights.
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|Publication number
|Publication type
|Application number
|Publication date
|Mar 29, 1994
|Filing date
|Apr 28, 1992
|Priority date
|Apr 28, 1992
|Fee status
|Publication number
|Ian R. Flockhart, Joseph H. Cort
|Original Assignee
|Corint, Ltd.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (3), Referenced by (48), Classifications (8), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
______________________________________Component Weight %______________________________________a) Polyvinylpyrrolidone 20-30 (mol. wt. 30,000)b) Crodesta sucrose ester(s) 0.1-3.0c) Propan 1,2-diol 1-10d) C12 -C18, alcohol 1-10e) PEG 1000 9-12f) PEG 1500 1-2g) PEG 4000 30-45h) PEG 8000 3-4j) Terpene ether, 0.2-0.5.______________________________________
______________________________________Component Weight %______________________________________a) Polyvinylpyrrolidone 20-30 (mol. wt. 30,000)b) Crodesta sucrose ester(s) 0.1-3.0c) Propan 1,2-diol 1-10d) C12 -C18, alcohol 1-10e) PEG 1000 9-12f) PEG 1500 1-2______________________________________
______________________________________Component Weight %______________________________________g) PEG 4000 30-45h) PEG 8000 3-4j) Terpene ether 0.2-0.5______________________________________
1) Field of the Invention
The present invention relates, in general, to a novel pharmaceutical composition containing biologically-active desmopressin, a vasopressin-based oligopeptide, in combination with a matrix buccal patch. More particularly, the invention is generally concerned with a buccally-administered solid pharmaceutical composition containing various doses of the active component dispersed in a buccal patch matrix. The invention allows reproducible, patient-friendly administration of the drug even when the patient has nasal congestion since one usual mode of administration of desmopressin is by nasal drops or spray. The composition is well-tolerated by patients of all ages, is just a effective as when administered by nasal drops or spray, provides prolonged and reliable action and can be stored at room temperature.
2) Description of the Related Art
It has long been recognized that natural vasopressin has useful biological effects, such as antidiuresis, vasoconstriction of visceral blood flow and release of hematological clotting factors. Its utility, however, is limited by its short half-life as well as by its well-known systemic pressor effect which includes cardio-toxicity.
A variety of analogs of vasopressin have been synthesized in an effort to modify the properties of vasopressin and provide products having increased pharmaceutical utility. For example, vasopressin has been modified by desamination of cysteine in position 1 and replacement of arginine by its D-isomer at position 8 to yield desmopressin, hereinafter also referred to as "dDAVP". Desmopressin, which is immune to enzymatic cleavage as of the 1-2 and 8-9 C--N bonds, exhibits prolonged antidiuretic action and virtually no pressor action or cardio-toxicity. For example, see U.S. Pat. Nos. 3,497,491 and 4,235,881. In further modifications, the disulfide bridge has been replaced with a thioether linkage (--CH2 S-- or --SCH2 --) or an ethylene (--(CH2 --) linkage. See also U.S. Pat. No. 3,980,631.
These vasopressin-based oligopeptides have been administered by a variety of routes and in combination with a variety of pharmaceutical carriers and additives. For example, dDAVP has been administered intranasally, subcutaneously, intravenously and intramuscularly in physiological saline at pH 4.
Various attempts have also been made to effectively orally administer vasopressin-based oligopeptides, particular dDAVP. It has been traditionally accepted that such peptides are cleaved into inactive fragments in the gastrointestinal tract with little nonapeptide adsorption taking place. dDAVP has been incorporated in gelatin-based sub-lingual lozenges (A. Grossman et al. "Two new modes of desmopressin (dDAVP) administration", British Medical Journal May 17, 1980, 1215). A difficulty with sub-lingual lozenge is the necessity for the patient to restrain tongue movement so as not to swallow it and the fact that the sub-lingual salivary glands are very productive of secretion, which carries off a variable and unknown quantity of the drug to be swallowed.
Additionally, dDAVP has been formulated into an orally administered (swallowed) composition in the form of a tablet with various fillers and inert constituents. The effective claimed dosage would appear to be 100-200�the intravenous level, but a difficulty remains with all swallowed forms of oligopeptides--there will be a considerable patient-to-patient and day-to-day (in one and the same patient) variation in how much of the dosage is enzymatically cleaved and what fraction remains intact to be absorbed. Furthermore, if any such tablet or lozenge is gelatin-based, the water content will limit stability--thus, both the lozenges and the oral tablets are stored at 3�-8� C. Finally, the time-of-onset of any activity from a dose presented in the gut will vary from patient to patient and, in the same patient, from day to day.
It is known in the art that various chemical compositions can be administered to patients through the mucous membranes of the body. Suppositories for rectal/vaginal administration are well known as well as nasal sprays and drops. More recently, the patent literature has disclosed the administration of pharmaceutically active chemicals through the mucous membrane of the mouth. For example, in U.S. Pat. No. 4,764,378 which issued Aug. 16, 1988 to A. D. Keith et al. there is disclosed a buccal drug dose form for the transmucosal administration of drugs using an erodible matrix. A wide variety of other issued patents, both foreign and domestic are cited therein which pertain directly or indirectly to buccal drug dose forms and their methods of use. However, while the claims therein include heat-sensitive active substances such as Desmopressin, Calcitonin and Growth Hormone, no data has been presented therein, or elsewhere, that oligopeptides and protein hormones can survive the about 40� C. and one to two hour conditions used to include a drug in the given matrices. For Desmopressin no data has, to date, been presented at all. For Calcitonin and Growth Hormone the only data given are the approximate composition of the carrier mix and the statement that the latter hormones could be mixed therein, without mention of their chemical state and activity after mixing.
Accordingly, one or more of the following objects will be achieved by the practice of the present invention. It is an object of this invention to provide a pharmaceutical composition in the form of a buccal patch which contains biologically active desmopressin. A further object is to provide a composition in the form of a patch which is stable and can be stored at room temperature for extended periods of time. Another object of the present invention is to provide a method for administering desmopressin to a patient in need of such treatment and who at that time is experiencing nasal congestion. A still further object of the invention is to provide a method whereby desmopressin can be administered to a patient rapidly and in a manner which provides a sustained release of a continuous, even dosage over a period of time. These and other objects will readily become apparent to those skilled in the art in light of the teachings herein set forth.
In its broad aspect, the present invention is directed to a pharmaceutical composition in the form of a buccal patch containing a therapeutically effective amount of desmopressin which is stable in the dry state and therefore can be stored at room temperature. The invention is also directed to a process for the preparation of the pharmaceutical composition and its use in the treatment of a variety of conditions. In the process of accomplishing the above, comparisons have been made between a previously reported carrier composition (see U.S. Pat. No. 4,764,378) and the carrier composition which is described in British Patent Application, GB 9122765.2 filed October, 1991 by I. R. Flockhart et al.
FIG. 1 is a graph depicting the antidiuretic changes for several buccal dosages (μg/kg) vs. time (hours) after dDAVP buccal administration in a carrier composition designated as "Z".
FIG. 2 is the same as FIG. 1, but with dDAVP incorporated in the carrier composition of the present invention, designated as "F".
FIG. 3 is a graph depicting total dDAVP buccal dosage vs. mean T1/2, comparing carrier Z and carrier F presentations.
FIG. 4 is a graph depicting estimates of mean area under the curve (AUC) values of antidiuretic responses vs. total buccal dosage, comparing carrier Z with carrier F presentations, all of the above being data from the same group of probands.
In view of the present invention, it has now been found possible to provide a novel pharmaceutical composition containing dDAVP, in dry form, on a matrix buccal patch which is stable, simple to insert, is hardly felt, dissolves within about 20 minutes, delivers its contained drug for absorption by the local mucous membrane, and can be stored at room temperature if access to moisture is prevented. In particular, it has been found to have a dose-related antidiuretic response in amplitude and particularly in duration (T1/2), and total delivered activity (as measured by AUC) with the same or better degree of prolongation as that achieved by intranasal aqueous forms. The time of onset of the activity is short and predictable.
The invention thus improves patient compliance, particularly in the presence of nasal congestion with upper respiratory infections or in patients who need the drug following transsphenoidal surgery on the hypothalmus or pituitary. It can be used with advantage by patients with Diabetes insipidus, childhood enuresis and incontinence in general and all other approved and/or investigated uses of dDAVP, including all hematological uses. See P. M. Manucci, "DESMOPRESSIN: A Nontransfusional Hemostatic Agent", Annual Review of Medicine 4,1990, 55 and S. Reichlin, "The Neurohypophysis, Physiological and Clinical Aspects", Plenum Medical Publ. N.Y. 1984.
As indicated above, the pharmaceutical composition of the present invention is comprised of a matrix buccal patch containing desmopressin. Desmopressin, as previously indicated, is a peptide which can be represented by the following formula: ##STR1##
Although Desmopressin can be administered orally, it has been observed, as discussed above, that peptides are commonly cleaved in the gastrointestinal tract into inactive fragments and accordingly, little or erratic absorption of the intact peptide takes place. Accordingly, for many applications, dDAVP is usually administered intranasally, by nasal drops or sprays. However, in those instances where a patient has nasal congestion this particular route of administration is not desirable.
It has been found that dDAVP can be conveniently administered to a patient by means of a buccal patch wherein the active component is dispersed in a matrix, hereinafter also referred to as "Matrix F". The matrix is comprised of the following components in the indicated percentages by weight, based on the total weight of the matrix itself:
______________________________________Component Weight %______________________________________a) Polyvinylpyrrolidone 20-30 (mol. wt. 30,000)b) Crodesta sucrose ester(s) 0.1-3.0c) Propan 1,2-diol 1-10d) C12 -C18, alcohol such 1-10 as Dodecanol, laurel or hexadecanole) PEG 1000 9-12f) PEG 1500 1-2g) PEG 4000 30-45h) PEG 8000 3-4j) Terpene ether, such as 0.2-0.5 1,8 cineole (eucalyptol)______________________________________
Each of the above components serves a definite function, as indicated below, in imparting the desired properties to the buccal patch matrix.
1. Low Dalton PEG's determine the consistency and melting pt. of the buccal patch and can range from 25 to 75%.
2. High Dalton PEG's and polyvinylpyrrolidone serve to further modulate the consistency of the patch and can range from 2 to 45%.
3. Crodesta sucrose ester is a sucrose cocoate ester (which can be replaced by Crodestas F10, F50, F110, F140 and F160) acts as an emulsifying and dispersing agent which are cleared as food additives.
4. Dodecanol/propan 1.2-diol is a combination of a fatty alcohol with either linear or branched chains (containing between 6 and 20 carbon atoms) with a di-hydroxylic alcohol (diol) (containing between 2 and 10 carbon atoms) which act, in combination with Crodesta, as penetration enhancers.
5. Cineole (a terpene ether which can be replaced by other similar molecules such as menthol, menthone, pulegone, etc.) may serve as a penetration co-enhancer but definitely serves as a taste masking device in the present case.
A particularly preferred formulation for the pharmaceutical composition of the present invention comprised of matrix F, is as follows:
______________________________________Component Grams Used Weight %______________________________________a) Polyvinylpyrrolidone 2.75 27.3 (mol. wt. 30,000)b) Crodesta sucrose ester(s) 0.23 2.3c) Propan 1,2-diol 0.47 4.7d) C12 -C18, alcohol such 0.32 3.2 as Dodecanol, laurel or hexadecanole) PEG 1000 0.95 9.4f) PEG 1500 1.04 1.0g) PEG 4000 3.82 38.0h) PEG 8000 0.38 3.8j) Terpene ether, such as 0.050 0.5 1,8 cineole (eucalyptol)k) Desmopressin (dDAVP) 0.050 0.5______________________________________
In practice the compositions were prepared as follows:
Components a-f were melted gently together and stirred to produce an homogenous mass.
Components g-j were added to the above and melted together at a temp. not exceeding 80� C. The temp. was then allowed to decrease slowly with mechanical mixing until the temp. reached a value between 30� and 40� C., when (dDAVP) was added. This last procedure, only about 30 min. in duration, prevents heat inactivation of the peptide and is much shorter than the procedure used in Matrix Z.
The buccal patch can be prepared by a variety of methods and in several configurations known to those skilled in the art. Preferably, the buccal patch is in the form of a thin wafer or disk which can firmly adhere to the mouth mucosa and provide sufficient contact area so as to release Desmopressin quickly and in the desired amount.
The final buccal patch, preferably of an approximate size 7-10 mm�7-10 mm�1 mm, is a light but firm object when dry, and can be protected from moisture by presentation in a blister pack. It can easily be inserted between the gums and the cheek on either side, where it is hardly felt. There it absorbs heat from the mucosa to ensure slow melting and fluid from saliva to enable solution of the peptide. Within 10-30 mins. it melts and can no longer be felt, during which time the dose of peptide contained in the patch has been presented for absorption. The only restrictions on the patient are not to eat or drink during the melting time so as not to increase salivation and/or mechanically dislodge and swallow the patch.
The preferred concentration of Desmopressin in each individual buccal patch is from about 15 to about 250 μg, and more preferably from about 25 to about 100 μg.
A particularly desirable feature of the pharmaceutical compositions of the present invention is that they are stable at room temperature if protected from moisture. The shelf life of the buccal patches at room temperature is up to two years or more.
In order to demonstrate that the pharmaceutical composition of the present invention possesses superior properties to buccal patch compositions of the prior art, a comparison was made between a pharmaceutical composition comprised of the matrix F of the present invention and a pharmaceutical composition comprised of a matrix similar to that of the aforementioned U.S. Pat. No. 4,764,378, which also disclosed Desmopressin as an active component. This formulation was labelled "Matrix Z" and has the following composition:
______________________________________Component % by Weight______________________________________Low Molecular weight polyethylene 20-75glycol (PEG), 100-4000 Daltons,(Melting Pt. 37� C.)Medium to high mol. wt. PEG,6,000 2-54to 20,000 DaltonsPolyethylene oxide, mol. wt. 100,000 1-40to 5,000,000 DaltonsLong chain saturated carboxylic about 4acid (e.g. myristic acid)______________________________________
In general, comparing Matrix F with Matrix Z there has been a shift to alcohols from long chain acids and the addition of Crodesta sucrose ester(s). The m.p. of F, like that of Z, is 37� C.
As will be noted by the antidiuretic assays reported in the Examples, regardless of dose, the action of the hormone analog starts in 30-45 minutes after insertion and reaches its peak activity within 60-90 minutes after insertion. The subsequent duration of activity is highly dose-dependent as shown in terms of mean T1/2 values in hours:.
______________________________________ Dose T1/2______________________________________In Matrix Z: see FIG. 1) 0.8 μg/kg 1.7 1.2 5.0 1.54 8.0In Matrix F: see FIG. 2) 0.4 μg/kg 3.5 0.45 5.0 0.9 >7.5 1.54 >12.0______________________________________
All of the above times of onset and duration have been repeatedly seen in trained, human volunteers in a "Brattleboro Man" assay designed for dDAVP. See H. Nadvornikove et al., "A standardized desmopressin test of renal concentrating ability", Clinical Nephrology, 14, 1980, 142 and J. H. Cort et al., Role of the disulfide bridge and the C-terminal tripeptide in the antidiuretic action of vasopressin in man and the rat", Kidney International 8, 1975, 292.
Other comparative data is set forth in the examples and drawings.
The following examples are illustrative of the invention:
Buccal patches containing either 50 μg dDAVP/10μmg (Z patches) or 100 μg dDAVP/100 mg (F patches) were used in a "Brattleboro Man" assay on human volunteers (n=6). All probands received both matrices on separate occasions. Between receipt and the first assay, the patches were stored at room temp. away from sunlight (brown plastic or glass coverings) for 2-4 weeks. By the time the last assay series was carried out, with dosage repetition for rough orientation on stability, the storage duration at room temperature had reached 4-12 weeks. Variation in dosage was achieved by cutting the tablets with a scalpel and weighing the fragments, or by using multiple fragments. The dosages, on a wt. basis, ranged from 0.4 to 1.54 μg/kg. The volunteers were trained and experienced with the assay technique, with 4 to 15 years of previous dDAVP-related assays carried out on them, so that each volunteer had a well-documented reference background of antidiuretic responses.
Each assay day started at 6:00-6:30 AM, after 8 hours of sleep. No food was allowed until the late evening of the same day, and no drugs at all were taken, including aspirin. None of the females were pre-menstrual on assay days. Each subject emptied his/her bladder and was then given 30 minutes to drink 1.5% of body wt. (measured) as lukewarm weak tea (3 bags/5 1.) very slightly sweetened with aspartame only. The excretory periods throughout were 30 minutes in duration. After 30 minutes, the volume of urine produced was measured and recorded and the same volume+30 ml. (to account for an average of 1 ml./min. insensible water loss--respiration and sweat--in a temperate climate) of the same tea was drunk. The water load is sufficient to suppress endogenous vasopressin secretion for that subject--the maintenance water loading kept the initial 1.5% dilution constant throughout the experiment. When two successive 30-minute periods showed the same rate of urine flow, the buccal matrix patches containing dDAVP were put in place. In the case of matrix F, blindly labelled blank patches, without dDAVP, were also made in the same manner and were tested. All the placebo blanks were without activity. Since maximum urine flow rates ranged from 11.0 to 18.0 ml/min (0.0035 ml./kg.min. to 0.01 ml/kg.min) the dDAVP-related decreases in urine flow rate were evaluated as (-) delta % flow-rate, counting down from 100% =max. pre-dDAVP flow rate. With matrix Z, three dosages were used: 0.8, 1.2 and 1.54 μg/kg. With matrix F, there also were three dosage ranges: about 0.4-0.45, 0.8 and about 1.6 μg/kg.
FIG. 1 gives the mean (-) delta % changes for the 3 buccal dosages in matrix Z vs. time (h.) after dDAVP buccal administration. Antidiuresis started by 30-45 minutes after administration in all cases, and peak antidiuresis was reached in all cases by 20-60 min. after administration.
FIG. 2 shows the same data as in FIG. 1 for the same probands, but this time the dDAVP was in matrix F. The principal difference between the responses was a dose-related T1/2, with the F-matrix doses producing longer antidiuretic effects per dose than the Z-matrix doses.
FIG. 3 plots the T1/2 data (h.) vs. dose for each of the two matrices separately. Taking T1/2 as a measure of bio-availability, the F-matrix appeared to have delivered about twice the amount of dDAVP (all made from the same synthetic batch of raw material) as the Z-matrix material.
FIG. 4 plots the area-under-the-curve (AUC) calculation of total delivered antidiuretic activity (here simplified to peak activity�T1/2) separately for the two matrices. Again, it would appear that the F-matrix delivered about twice as much antidiuretic activity as the Z-matrix material did.
Estimation of bio-availability in absolute % of administered dose absorbed and effective is very difficult only on the basis of one activity--antidiuresis--in a small group of probands. In general, it has been established that intranasal drops/spray get about 10% of the administered dose into the patient's circulation. The equivalent antidiuretic response to Z-matrix patches suggests that 7.5 to 10 times the dose must be given buccally as that given intranasally, i.e., the bio-availability would be 2-2.5% compared to i.v. administration. The apparent bio-availability of 5-7%, which from F-matrix buccal patches would then be about 5-7%, which approaches the efficiency of delivery from intranasal administration.
Thus, for F-matrix buccal patches, the preferred range of doses is from about 25 to about 50 μg/patch.
A drug formulation is not, however, evaluated by efficacy alone. Ordinary oral pills or sub lingual lozenges require 10-20 times the intranasal dose, but suffer from lack of patient to patient and day-to-day (in the sam patient) reliability and repeatability. Buccal patches can almost reach intranasal spray efficacy, but are even more reliable and repeatable than the intranasal formulations because they are independent of nasal congestion for whatever reason. Buccal patches can be kept at room temperature, which is a distinct advantage over all other dDAVP formulations, which require refrigeration at 3�-8� C.
While the present invention is directed primarily to buccal patches comprised of the F-matrix, the same formulation can be used for the preparation of suppositories. Suppositories comprised of the F-matrix formulations can contain one or more active components, such as desmopressin or other components such as calcitonin and the like.
Although the invention has been illustrated by the preceding examples, it is not to be construed as being limited to the indications related to the biological test, or to the materials employed therein. Rather, the invention is directed to the generic area as hereinbefore disclosed and should also cover other peptides such as Calcitonin and Growth Hormone. Various modifications and embodiments thereof can be made without departing from the spirit or scope thereof.
|Cited Patent
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|Nov 12, 2003
|Sep 21, 2010
|Allergan, Inc.
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|Nov 3, 2006
|Mar 22, 2011
|Teva Women's Health, Inc.
|Method for making a lollipop
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|Ferring B.V.
|Pharmaceutical formulations
|Nov 12, 2004
|Feb 21, 2012
|Ferring Bv
|Blister pack and solid dosage form therefor
|Mar 27, 2012
|Allergan, Inc.
|Pharmaceutical compositions including low dosages of desmopressin
|Jun 5, 2006
|Jun 19, 2012
|Teva Women's Health, Inc.
|Attachment of a handle to a solid oral dosage form
|Mar 19, 2013
|Allergan, Inc.
|Methods and devices for desmopressin drug delivery
|Feb 2, 2006
|Mar 4, 2014
|Alza Corporation
|Transdermal drug delivery devices having coated microprotrusions
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|Jun 10, 2014
|Colgate-Palmolive Company
|Oral care implement with cavitation system
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|Jul 1, 2014
|Columbia Laboratories, Inc.
|Bioadhesive progressive hydration tablets
|May 18, 2011
|Aug 12, 2014
|Ferring B.V.
|Methods of treatment using orodispersible desmopressin pharmaceutical formulations
|Aug 1, 2008
|Mar 31, 2015
|Gp Pharm, S.A.
|Oral pharmaceutical composition of desmopressin
|Jan 19, 2006
|Dec 1, 2015
|Neurohealing Pharmaceuticals, Inc.
|Methods and compositions for decreasing saliva production
|Jul 9, 2014
|Dec 29, 2015
|Ferring B.V.
|Methods using desmopressin acetate in orodispersible form
|Feb 15, 2013
|Jun 28, 2016
|Allergan, Inc.
|Methods and devices for desmopressin drug delivery
|Oct 26, 2001
|Sep 12, 2002
|Cormier Michel J.N.
|Transdermal drug delivery devices having coated microprotrusions
|Apr 24, 2003
|Jan 1, 2004
|Levine Howard L.
|Bioadhesive progressive hydration tablets
|Nov 12, 2003
|Jul 15, 2004
|Fein Seymour H.
|Pharmaceutical compositions including low dosages of desmopressin
|May 7, 2004
|Nov 11, 2004
|Cephalon, Inc.
|Dissolvable backing layer for use with a transmucosal delivery device
|May 7, 2004
|Nov 11, 2004
|Cephalon, Inc.
|Dissolvable backing layer for use with a transmucosal delivery device
|Aug 15, 2003
|Feb 17, 2005
|Kimberly-Clark Worldwide, Inc.
|Thermoplastic polymers with thermally reversible and non-reversible linkages, and articles using same
|May 7, 2003
|Oct 20, 2005
|Ferring B.V.
|Pharmaceutical formulations
|Feb 2, 2006
|Sep 7, 2006
|Cormier Michel J
|Transdermal drug delivery devices having coated microprotrusions
|Jun 5, 2006
|Dec 14, 2006
|Chowdhury Tahseen A
|Attachment of a handle to a solid oral dosage form
|May 11, 2006
|Feb 8, 2007
|Levine Howard L
|Bioadhesive progressive hydration tablets
|Nov 3, 2006
|May 17, 2007
|Chowdhury Tahseen A
|Work Holder for Use in and a Method for Making a Lollipop
|Nov 12, 2004
|May 24, 2007
|Kristin Wannerberger
|Blister pack and solid dosage form therefor
|May 4, 2007
|Nov 15, 2007
|Fein Seymour H
|Pharmaceutical Compositions Including Low Dosages of Desmopressin
|Jul 15, 2008
|Nov 6, 2008
|Fein Seymour H
|Pharmaceutical compositions including low dosages of desmopressin
|Jul 15, 2008
|Jan 1, 2009
|Fein Seymour H
|Pharmaceutical compositions including low dosages of desmopressin
|Apr 21, 2005
|Feb 5, 2009
|Stanko Skrtic
|Pharmaceutical compositions for acute glucocorticoid therapy
|Oct 22, 2009
|Jobdevairakkam Christopher N
|Composition of Rapid Disintegrating Direct Compression Buccal Tablet
|Nov 26, 2009
|Ferring International Center S.A.
|Methods comprising desmopressin
|Jun 4, 2008
|Nov 4, 2010
|James Herbert Kemp
|Oral Care Implement With Cavitation System
|Oct 26, 2001
|Aug 5, 2009
|Alza Corporation
|Transdermal drug delivery devices having coated microprotrusions
|Aug 2, 2007
|Oct 17, 2012
|Medimmune Limited
|Human antibodies to ERBB2
|Oct 26, 2001
|Nov 28, 2002
|Alza Corporation
|Transdermal drug delivery devices having coated microprotrusions
|May 7, 2003
|Nov 20, 2003
|Ferring Bv
|Desmopressin in an orodispersible dosage form
|May 7, 2003
|Jul 22, 2004
|Ferring Bv
|Desmopressin in an orodispersible dosage form
|Aug 1, 2008
|Mar 5, 2009
|Gp Pharm S.A.
|Oral pharmaceutical desmopressin composition
|U.S. Classification
|424/435, 424/486
|International Classification
|Cooperative Classification
|European Classification
|Apr 28, 1992
Owner name: CORINT, LTD., SWITZERLAND
Free format text: ASSIGNMENT OF 1/2 OF ASSIGNORS INTEREST TO EACH ASSIGNEE;ASSIGNORS:FLOCKHART, IAN R.;CORT, JOSEPH H.;REEL/FRAME:006111/0514
Effective date: 19920414
Owner name: EAST RIDING LABORATORIES, LTD., UNITED KINGDOM
Free format text: ASSIGNMENT OF 1/2 OF ASSIGNORS INTEREST TO EACH ASSIGNEE;ASSIGNORS:FLOCKHART, IAN R.;CORT, JOSEPH H.;REEL/FRAME:006111/0514
Effective date: 19920414
|Sep 19, 1997
Owner name: CORT, JITKA, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CORINT LTD.;REEL/FRAME:008709/0860
Effective date: 19970825
|Sep 22, 1997
|Fee payment
Year of fee payment: 4
|Oct 23, 2001
|Maintenance fee reminder mailed
|Mar 29, 2002
|Lapse for failure to pay maintenance fees
|May 28, 2002
|Expired due to failure to pay maintenance fee
Effective date: 20020329


text:
Item # 50460
branson jumpsuit
Item # 50460
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Item # 50460Questions? We have the answers.
Additional Information
Tailored and sophisticated in a heavyweight crepe from Japan, this polished jumpsuit is cut from luxurious has a waist-defining seam and a keyhole detail at the back.
- Made with an innovative double-faced fabric that is a matte crepe texture on one side and shiny satin on the other
- 82% Triacetate, 18% Polyester
- Fabric from Japan
- Imported
- Dry Clean
- Fits true to size. Take your normal size.
- Model is 5'9"/175cm wearing a size 4


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"If you establish a democracy, you must in due time reap the fruits of a democracy. You will in due season have great impatience of the public burdens, combined in due season with great increase of the public expenditure. You will in due season have wars entered into from passion and not from reason; and you will in due season submit to peace ignominiously sought and ignominiously obtained, which will diminish your authority and perhaps endanger your independence. You will in due season find your property is less valueable, and your freedom less complete." ~ Benjamin Disraeli
Control Your Local Police
Submitted by Don Stacy on Tue, 2013-02-19 01:00
"While reflecting on recent episodes of police misconduct in my community and beyond, I began to think about how much law enforcement agencies resemble the Catholic Church. And no, this is not a pre-St. Patrick's day Irish joke. Consider the following: The Church and police departments have both become safe havens for criminal abusers of authority. Both are allergic to accountability. Both are hierarchical institutions that value blind obedience and discourage internal dissent. Both focus more on covering their posteriors than they do on removing criminals from their ranks. Finally, neither of these entities truly value input from their respective communities."
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text: The solar system is doomed and so are youRobbie Gonzalez9/26/12 4:30pmFiled to: WebcomicsxkcdGoofballeryRandall munroeSpaceScienceSciAstronomyastrophysicstweetFb22EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalink XKCD's Randall Munroe on the inexorable march toward complete and total solar devastation. Best to just hunker down and wait for our star to turn us into crispy bits, right? Granted, our fiery fate is still a ways off, but in situations such as these it's always a good idea to resign to one's demise well ahead of time. Or, you know, get ourselves the hell off this rock.See also: this great interview with Munroe about the motivation for creating his recently launched "What If?" series. What is the "What If?" series? Have you ever wondered how much force power Yoda wields? Wonder no more. [XKCD]Reply22 repliesLeave a reply


text:
A wedding is one of the most important days in two people's lives. It's that special occasion when you give your most solemn and loving vows to your special someone in front of everyone who has ever mattered to you. Having said that, it's no wonder that couples go to great lengths to have that one perfect day where everything is beautiful. Of course, making everything beautiful involves choosing the perfect backdrop for your wedding. For those who can afford it, a wedding abroad can more than justify the costs of flying everyone over great distances for a truly special time. Whether it's the beaches of the Bahamas, the cherry blossom-filled streets of Japan or the great Australian outdoors, an out-of-country wedding guarantees indelible memories for lovers, their families and their friends. However, since most people only get married once, choosing the best location becomes a real dilemma when it […]
Yes! Please send me my FREE Insider Italy Vacation Checklist with all the insider travel secrets I'll need for a perfect Italy vacation.
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"The trip was really great!"
The hotel accommodations were spacious and clean. The tour guides and transfer people were all great. You really put together exactly what we asked for. I will definitely use your services again and definitely refer you to family and friends. Thanks
Robert Miceli (Wickliffe, OH)
Group Customized Package, June 2013


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When I read it was constructed of wood, I expected it to be sturdy... it was not. Made of particle board, it is flimsy and I am seriously wishing I had put my money into a more expensive, sturdier unit. If I knew it was made of particle board I would have skipped over it. Particle board is recycled wood, compressed in a way that makes it unpaintable when it gets scratched and shelves like this DO get scxratches. I would say it is basically a piece of JUNK!
- How did the color on site compare with the actual product? The color matched up fine with what I saw on the website. It was why it got two stars.
- Please tell us about the quality of the product. The unit is very poor quality... very tiippy. I had to put something under the front feet to tip it backwards slightly so it would stay against the wall and not tip forward.
- How accurate was the on site description of the product? The picture was fine but it was NOT constructed of "wood". It is constructed of "particle board"
I am pleased with the appearance and finish; it is nicely done. It sturdy and is just the right size. The assembly was easy and fast.
The cabinet is classy, and beautiful. I bought one and loved it so much I purchased another. They're great. It looks nice, went together easily, I just wish it weren't made so cheaply. I think tho, that it's just the way EVERYTHING is today.
This shelf is just what I needed to display some collectables that were handed down to me by my mother. I was a little intimidated when I first opened the box because it does require assembly, and there were quite a few pieces to put together. However, once I actually looked at the directions, it took me less than 5 minutes to assemble it. It seems sturdy, and is just the right size so it can go almost anywhere. The finish was also nicely done. I'm thinking about getting a second one for additional items.
The stand is very much like the picture. It is durable and a very nice looking stand well worth the money.
color matched baby furniture in nursery. A good addition to a corner that would have been wasted space. easy to put them together as well.


text: 3. Digital Realty Trust ( DLR) is a real estate investment trust specializing in data centers. Goldman is bullish on the data storage REITs due to "compelling data and cloud-driven IT demand trends coupled with lagging near-term supply growth." Digital Realty's scheduled to report fourth-quarter results Feb. 18. Its stock has climbed nearly 7% since Goldman added it to the Conviction Buy List, but still has 17% of upside potential. It is cheap relative to other REITs based on funds from operations. Its cash flow multiple of 15 reflects a 20% peer discount. Since 2008, Digital Realty has grown sales, net income and earnings per share 29%, 30% and 61% a year, on average. Its stock delivered annualized gains of 14% over that span. Currently, 13, or 65%, of researchers advise purchasing the REIT, four say to hold and one recommends selling. The stock yields 3.9% and the distribution has grown 37% in the past 12 months. The payout has grown 20% and 15% annually, on average, over a three- and five-year span, respectively. Prev 4 of 7 Next


text:
Jay Leno had a very special guest stop by his garage recently. Peter Mullin and his Pebble Beach-winning 1934 Voisin C-25 Aerodyne took the time to visit the comedian and car enthusiast for a brief spell. It's no secret Leno is a fan of '30s French vehicles, and the Aerodyne holds a special place in his heart. The vehicle was a marvel of innovation when it debuted, featuring a 3.0-liter inline six-cylinder sleeve-valve engine, a mechanized retractable hardtop sun roof and an interior that could
2011 Pebble Beach Concours d'Elegance Best in Show
Jay Leno's Garage welcomes 2011 Pebble Beach Best in Show winner
- Zach Bowman
- Dec 29, 2011
Peter Mullin's 1934 Voisin C-25 Aerodyne named 2011 Pebble Beach Concours d'Elegance Best of Show
- Drew Phillips
- Aug 21, 2011
The judges at this year's 2011 Pebble Beach Concours d'Elegance have been searching all day to find this year's 'Best in Show', and they have finally come up with a winner. Peter Mullin's 1934 Voisin C-25 Aerodyne earned the title after being named the best car in the 1932-1937 European Classic category. Yes, the same Peter Mullin of the renowned Mullin Automotive Museum.
- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
- Infiniti dealers ranked best, Tesla worst
- Compare Volvo XC90 and Lincoln MKX


text: When we tacitly assume that we are the primary actors in worship, then we also assume that worship is basically an expressive endeavor. This is why we now constrict "worship" to the song service of our gathering, the time in the service when we can express ourselves. We think of worship primarily in a bottom-up framework, as a way for us to express our praise and show our devotion--as if worship gathers us to perform… [more]


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Pacific Resort Realty, LLC
Phone: (808) 887-1141 Fax: (808) 326-9784 View Additional Phone Numbers 75-5705 Kuakini Hwy, Suite 4, Kailua Kona, HI 96740 http://www.pacificresortrealty.com
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This business is in an industry that may require professional licensing, bonding or registration. BBB encourages you to check with the appropriate agency to be certain any requirements are currently being met.
These agencies may include:
DCCA Professional & Vocational Licensing
335 Merchant St STE 301, Honolulu HI 96813
Phone Number: (808) 586-3000
The number is RB18849.
DCCA Professional & Vocational Licensing
335 Merchant St STE 301, Honolulu HI 96813
Phone Number: (808) 586-3000
The number is RB18553.
State of Hawaii Department of Taxation
PO Box 1425, Honolulu HI 96806
Phone Number: (808) 587-4242
The number is W27194518-01.
Type of Entity
Limited Liability Company (LLC)
Business ManagementMr. Brandon Wood, Manager Ms. Melody Sunahara, Principal Broker
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Property Management Real Estate Services
Alternate Business NamesPacific Property Services
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75-5705 Kuakini Hwy, Suite 4
Kailua Kona, HI 96740 (808) 887-1141 (808) 960-4396 Directions
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Complaint Detail(s)
Problems with Product/Service
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Additional Notes
Complaint: I rented a house over the holiday season from Pacific Resort Realty (****** ************* *** ****** ****) for $50,000 from 12/26 through 1/6. My son and his family arrived on 12/26, settled in to the house with their small children, and went to bed. During the night one family member was awoken by a mouse running across the bed. The following morning all of their perishable food had been partially eaten by the mice, even the crackers and baby food in the cabinets. Over the next few days mice were seen everywhere in the house including the bedrooms and baths along with mice droppings.My family had to eat all of their meals outside to prevent the mice from jumping on the dining room table.The realty company did little to stop this problem stating that it was a part of life in the islands. I arrived at the **** ******* about six days later and heard about the mice, complained to Pacific Resorts again, and asked for a meeting with Brandon W***, the owner. He did not respond to my request. My husband and myself emailed Brandon and called him asking for three nights rent as well as our damage deposit to be returned to us. We informed him that we could not live in a house with a rodent problem. As we had not moved into the house when my son and family left due to this problem, we think it only fair that a portion of this high rent be returned to us. My son and his wife suffered through the week at the house because they did not want to upset me. A problem of this magnitude did not begin overnight but has clearly been going on for a while and is a result of poor maintenance and hygiene by the realty company.
Desired Settlement: Immediate return of our $5000.00 deposit as well as a prorated share of the $50,000.00 rent for the three unused nights.
Business Response:
We take this complaint seriously and have been in contact with the tenants and their representatives to try and resolve this in the best possible manner. We hope to have a resolution soon.
The tenants did arrive on 12/26. The tenants first brought this to our attention on January 1st ( 7 days later) informing us that there were evidence of mice activity. The very next day our Director went to the home first thing to try and handle the situation. He then came back that evening and stayed until 7PM to try and catch any mice that might be around.
We did respond as soon as we heard the complaint.
Our staff was told from the guests, during our staff's visits to the home, that they actually preferred to eat outside and it wasn't mice activity that was causing them to eat outside. We did kindly request from the guests to please not wait to tell us if there is any sort of problem. We can only remedy a potential problem if we are aware of the situation.
The tenants did send me an email on 1/1, but I was out of town and on holiday with my family so had not seen the email.
When they did call me the following Sunday on 1/3, I picked up right away. I had also been in contact with our staff and was aware they were at the home attending to the guests.
We did everything we knew how to do to mitigate any possible mice situation. We rented the home over 130 nights over the last two years and we have never had a complaint of this nature.
I am sorry the guests got the impression that we did not respond or did little to stop the problem.
Again, we are in the process of trying to resolve their complaints.
We are returning the full security deposit although there was an expensive vase that was broken, which the tenant confirmed.
We will be offering a rebate to the customer shortly which we feel is acceptable.
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The Remains of the Day Hardcover – 22 May 1989
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Amazon Review
The novel's narrator, Stevens, is a perfect English butler who tries to give his narrow existence form and meaning through the self-effacing, almost mystical practice of his profession. In a career that spans the second world war, Stevens is oblivious of the real life that goes on around him--oblivious, for instance, of the fact that his aristocrat employer is a Nazi sympathizer. Still, there are even larger matters at stake in this heartbreaking, beautifully crafted novel-- namely, Stevens' own ability to allow some bit of life-affirming love into his tightly repressed existence. --This text refers to an out of print or unavailable edition of this title.
"An intricate and dazzling novel." --"The New York Times"
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"Brilliant and quietly devastating." --"Newsweek "
" "
"""A virtuoso performance ... put on with dazzling daring and aplomb." --"The New York Review of Books"
" "
"A perfect novel. I couldn't put it down." --Ann Beattie
" "
"The novel rests firmly on the narrative sophistication and flawless control of tone ... of a most impressive novelist." --Julian Barnes
An intricate and dazzling novel. "The New York Times"
Brilliant and quietly devastating. "Newsweek "
" "A virtuoso performance ... put on with dazzling daring and aplomb. "The New York Review of Books"
A perfect novel. I couldn t put it down. Ann Beattie
The novel rests firmly on the narrative sophistication and flawless control of tone ... of a most impressive novelist. Julian Barnes" --This text refers to an out of print or unavailable edition of this title.
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Top Customer Reviews
It is a story of hopelessness, a journey of self discovery and a love story, told simply. At the end, you are both exasperated with the narrator as well as desperately sorry for him.
an exquiste read
An aging English butler called Stevens sets off on a quiet motoring tour of Devon in the late 1950s. As he drives leisurely through the English countryside, he muses on times past and the exact nature of 'greatness', a quality which he has strived to attain all his life.
Stevens is perhaps one of the most distinctive characters that I have encountered during my reading life. He is the perfectionist to end all perfectionists, but his demands for everything to be correct are as stringent on himself as they are when he is supervising the rest of the dwindling staff at Darlington Hall. He is devoted to his work and does not let anything-or anyone-shake off his persona of efficiency and manners. This means that he hides his real emotions for most of the book, and is reluctant even to reveal them to the reader. His new master, an American, is fond of making jokey remarks to Stevens which would be unheard of when he was serving Lord Darlington and seem to shock him. His faltering attempts to make light bantering conversation add a touch of gentle humour to what is essentially a rather sad story.
Overall, The Remains Of The Day is a superbly crafted book, with all the plot's undertones of politics, romance, patriotism, etiquette and 'greatness' perfectly managed. One of the best passages has to be where Stevens explains why the English landscape is one of the world's greatest, and if you've ever visited Devon, even in this age of motorways and housing estates, you will see what he means. This book is really one of the best I've ever read, and the 1989 Booker Prize is well deserved. A true, beautiful classic.
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A wonderful book, very carefully crafted, every word seems to have been considered very thoroughly before inclusion, I would recommend this book to anyone who enjoys good quality... Read morePublished 1 month ago by Jill Wright
Seen the film a few times & enjoyed it. The book is very similar...He's a different kind of author & you need to concentrate.Published 3 months ago by John Little
Kazuo simply smashes it out if the park. He approached thus story of a brilliant actor researching a role hoping to find truths nit readily available in a script. Read morePublished 3 months ago by Fractal Echo
Very touching, tense with a bitter sweet ending. I absolutely loved the style of writing, the pace and structure felt perfect and the characters just seem to come alive off the... Read morePublished 4 months ago by MR RL PROBERT
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|Home » Articles » Directory
DMCI Holdings, Inc. Main Office Address | Telephone Number
3/F Dacon Building, 2281 Don Chino Roces Avenue
DMCI Holdings, Inc. Main Office Telephone Number:
(632) 888-3000Securities and Exchange Commission (SEC) Identification Number: AS095-002283
BIR Tax Identification No.: 004-703-376
This article was written by admin under the Directory category. It has been viewed times and generated 0 comments. The article was created on .
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Alaska Training Analyst Salaries
How much does a Training Analyst make in Alaska? Alaska Training Analyst salaries vary greatly from town to town. See below for Training Analyst salaries, bonus and benefits information for 6 cities in the Alaska area.
Below National Average
Above National Average
How much does a Training Analyst make in Alaska? Alaska Training Analyst salaries vary greatly from town to town. See below for Training Analyst salaries, bonus and benefits information for 6 cities in the Alaska area.
- Training Analyst Salaries in Anchorage, AK
- Training Analyst Salaries in Fairbanks, AK
- Training Analyst Salaries in Juneau, AK
- Training Analyst Salaries in Palmer, AK
- Training Analyst Salaries in Sitka, AK
- Training Analyst Salaries in Wasilla, AK
View US National Average Training Analyst Salaries
What is the Cost-of-Living in Alaska?
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Researches and develops training programs for an organization. Develops methods and materials for training staff and may prepare curriculum such as lectures, ideas for group discussions, demonstrations, and workshops. Evaluates training delivery, measures results, and recommends program changes. Must stay abreast of new training methods and determine relevancy to company employees. Requires a bachelor's degree in a related area and at least 5 years of experience in the field or in a related area. Relies on experience and judgment to plan and accomplish goals. Performs a variety of tasks. May lead and direct the work of others. A wide degree of creativity and latitude is expected. Typically reports to a manager or head of a unit/department.
Alternate Job Titles: Training Analyst
Categories: Training , Consulting Services , Human Resources


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Frances J. MainolfiAugust 25,2014Frances J. Mainolfi Rites
The funeral service for Frances J. Mainolfi, 92, of Rutland, who died Aug. 19, 2014, was held Saturday, Aug. 23, at Christ the King Church in Rutland.
Officiating was the Rev. Justin Baker, pastor.
Burial followed in St. Josephs Cemetery.
William Gower Johnson was organist. Brytani Munukka was the vocalist.
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