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Chronic Pancreatitis
- Author: Jason L Huffman, MD; Chief Editor: BS Anand, MD more...
Practice Essentials
Chronic pancreatitis is commonly defined as a continuing, chronic, inflammatory process of the pancreas, characterized by irreversible morphologic changes.
Essential update: AGA releases new guidelines for diagnosis/management of asymptomatic neoplastic pancreatic cysts
The American Gastroenterological Association recommends the following in the diagnosis and management of asymptomatic neoplastic pancreatic cysts[1] :
For asymptomatic mucinous cysts, a 2-year interval is recommended for a cyst of any size undergoing surveillance, with surveillance being stopped after 5 years if there is no change.
Perform surgery only if there is more than one concerning feature on MRI confirmed on endoscopic ultrasonography (EUS) and only in centers with high volumes of pancreatic surgery, and there should be no surveillance after surgery if there is no invasive cancer or dysplasia.
The risk of malignant transformation of pancreatic cysts is approximately 0.24% per year, and the risk of cancer in cysts without a significant change over a 5-year period is likely to be lower.
The small risk of malignant progression in stable cysts is likely outweighed by the costs of surveillance and the risks of surgery.
Positive cytology on EUS-guided fine-needle aspiration (FNA) has the highest specificity for diagnosing malignancy; if there is a combination of high-risk features on imaging, then this is likely to increase the risk of malignancy even further. Similarly, if a cyst has both a solid component and a dilated pancreatic duct (confirmed on both EUS and MRI), the specificity for malignancy is likely to be high even in the absence of positive cytology.
There is lower immediate postoperative mortality, as well as long-term mortality, for patients who undergo surgery in high-volume pancreatic centers.
It seems sensible to offer screening even after the cyst has been resected, provided the patients have not undergone total pancreatectomy. Surveillance should continue as long as the patient remains a good candidate for surgery. MRI every 2 years may be a reasonable approach for these patients. The clinician may elect to offer more frequent surveillance in the case of invasive cancer resection, particularly if there is concern that the lesion has not been fully resected.
Signs and symptoms
For most patients with chronic pancreatitis, abdominal pain is the presenting symptom. The patient experiences intermittent attacks of severe pain, often in the mid-abdomen or left upper abdomen and occasionally radiating in a bandlike fashion or localized to the midback. The pain may occur either after meals or independently of meals, but it is not fleeting or transient and tends to last at least several hours.
Other symptoms associated with chronic pancreatitis include diarrhea and weight loss.
See Clinical Presentation for more detail.
Diagnosis is based on tests of pancreatic structure and function.
Imaging tests
Imaging studies such as abdominal radiography and CT scanning can show inflammation or calcium deposits of the pancreas or changes in the pancreatic ducts. Pancreatic calcifications, often considered pathognomonic of chronic pancreatitis, are observed in approximately 30% of cases.
Endoscopic retrograde cholangiopancreatography
The endoscopic retrograde cholangiopancreatography (ERCP) test provides the most accurate visualization of the pancreatic ductal system and has been regarded as the criterion standard for diagnosing chronic pancreatitis. It combines the use of endoscopy and fluoroscopy to visualize and treat problems of the bile and pancreatic ducts. See the image below.
Magnetic resonance cholangiopancreatography
MRCP provides information on the pancreatic parenchyma and adjacent abdominal viscera, and it uses heavily T2-weighted images to visualize the biliary and pancreatic ductal system. This procedure is relatively safe, reasonably accurate, noninvasive, fast, and very useful in planning surgical or endoscopic intervention.
Endoscopic ultrasonography
The most predictive endosonographic feature of chronic pancreatitis is the presence of stones. Other suggestive features include the following:
Visible side branches
An irregular main pancreatic duct
Hyperechoic foci and strands
Dilation of the main pancreatic duct
Hyperechoic margins of the main pancreatic duct
See Workup for more detail.
Treatment is typically directed at the underlying cause of the pancreatitis and to relieve pain and malabsorption.
Pain relief
Pancreatic enzyme supplementation may be helpful in reducing pain. The hypothesis is that stimulation of the pancreas by food causes pain. Cholecystokinin (CCK) is one of the possible mediators of this response. When exogenous pancreatic enzymes are taken with a meal, CCK-releasing factors are degraded and CCK release in response to a meal is reduced. This decreases pancreatic stimulation and pain.
If conventional medical therapy is unsuccessful and the patient has severe, intractable pain, celiac ganglion blockade can be considered.[2] This approach tries to alleviate pain by modifying afferent sensory nerves in the celiac plexus, using agents that anesthetize, reduce inflammation, or destroy nerve fibers.
Endoscopic therapy aimed at decompressing an obstructed pancreatic duct can be associated with pain relief in some patients. The rationale for this approach is based on the hypothesis that ductal hypertension due to strictures of the main pancreatic duct leads to pain.[3, 4]
The choice of operation depends on the clinical problem and the preoperative assessment of the abnormality. In general, the approach aims either to improve pancreatic duct drainage or to resect the diseased organ. Data suggest that surgical drainage of the pancreatic duct is more effective than endoscopic drainage in patients with obstruction of the pancreatic duct due to chronic pancreatitis.
In patients with a dilated pancreatic duct, a Roux-en-Y side-to-side pancreaticojejunostomy is indicated. If the disease is limited to the head of the pancreas, a Whipple operation (pancreaticoduodenectomy) can produce good results.
See Treatment and Medication for more detail.
Chronic pancreatitis is commonly defined as a continuing, chronic, inflammatory process of the pancreas, characterized by irreversible morphologic changes. This chronic inflammation can lead to chronic abdominal pain and/or impairment of endocrine and exocrine function of the pancreas. (See Pathophysiology and Etiology.)
Chronic pancreatitis usually is envisioned as an atrophic fibrotic gland with dilated ducts and calcifications. However, findings on conventional diagnostic studies may be normal in the early stages of chronic pancreatitis, as the inflammatory changes can be seen only by histologic examination (see the images below). (See Workup.)
By definition, chronic pancreatitis is a completely different process from acute pancreatitis. In acute pancreatitis, the patient presents with acute and severe abdominal pain, nausea, and vomiting. The pancreas is acutely inflamed (neutrophils and edema), and the serum levels of pancreatic enzymes (amylase and lipase) are elevated. Full recovery is observed in most patients with acute pancreatitis, whereas in chronic pancreatitis, the primary process is a chronic, irreversible inflammation (monocyte and lymphocyte) that leads to fibrosis with calcification. (See Pathophysiology, Etiology, Presentation, and Workup.)
The patient with chronic pancreatitis clinically presents with chronic abdominal pain and normal or mildly elevated pancreatic enzyme levels. When the pancreas loses its endocrine and exocrine function, the patient presents with diabetes mellitus and steatorrhea. (See Presentation and Workup.)[5]
Patient education
For patient education information, see the Digestive Disorders Center and the Cancer Center, as well as Pancreatitis and Pancreatic Cancer.
Whatever the etiology of chronic pancreatitis,[6] pancreatic fibrogenesis appears to be a typical response to injury. This involves a complex interplay of growth factors, cytokines, and chemokines, leading to deposition of extracellular matrix and fibroblast proliferation. In pancreatic injury, local expression and release of transforming growth factor beta (TGF-beta) stimulates the growth of cells of mesenchymal origin and enhances the synthesis of extracellular matrix proteins, such as collagens, fibronectin, and proteoglycans.
Evidence indicates involvement of distinct chemokines in the initiation and perpetuation of chronic pancreatitis.
The cause of chronic pancreatitis usually is metabolic in nature. The proposed pathologic mechanisms of chronic pancreatitis are as follows:
Intraductal plugging and obstruction - Eg, ethanol (ETOH) abuse, stones, tumors
Direct toxins and toxic metabolites - These act on the pancreatic acinar cell to stimulate the release of cytokines, which stimulate the stellate cell to produce collagen and to establish fibrosis; cytokines also act to stimulate inflammation by neutrophils, macrophages, and lymphocytes (eg, ETOH, tropical sprue)
Oxidative stress - Eg, idiopathic pancreatitis
Necrosis-fibrosis - Recurrent acute pancreatitis that heals with fibrosis
Ischemia - From obstruction and fibrosis; important in exacerbating or perpetuating disease rather than in initiating disease
Autoimmune disorders - Chronic pancreatitis has been found in association with other autoimmune diseases, such as Sjögren syndrome, primary biliary cirrhosis, and renal tubular acidosis.
Secondary forms of autoimmune chronic pancreatitis are associated with primary biliary cirrhosis, primary sclerosing cholangitis, and Sjögren syndrome.
While alcohol greatly influences the understanding of its pathophysiology because it is the most common etiology (60-70%), approximately 20-30% of cases are idiopathic and 10% of cases are due to rare diseases.
Autoimmune pancreatitis
Autoimmune pancreatitis is a more recently described entity. Clinical characteristics include symptomatic or asymptomatic, diffuse enlargement of the pancreas, diffuse and irregular narrowing of the main pancreatic duct, increased circulating levels of gamma globulin, the presence of autoantibodies, and a possible association with other autoimmune diseases. Fibrosis with lymphocytic infiltration is seen on pathology. The disorder is associated with elevated immunoglobulin G4 (IgG4) concentrations.
In a study of 51 patients with autoimmune pancreatitis, Kawa et al suggested that a strong link exists between pancreatic stone formation and the recurrence of autoimmune pancreatitis and that following several recurrences, this disease may develop into chronic pancreatitis. In the study, the authors found that during a long-term follow-up period, 21 patients suffered a recurrence of the condition and 9 of the 51 patients developed pancreatic stones.[7]
The investigators also found that the stones developed more frequently in the recurrence group (7 [33%] of 21 patients) than in the other patients (2 [7%] of 30 patients). In addition, within a group of 175 patients with chronic hepatitis, 13 patients were found to have high serum concentrations of IgG4.
Alcoholic chronic pancreatitis
Excessive alcohol consumption is the most common cause of pancreatitis, accounting for about 60% of all cases.
In the affected gland, alcohol appears to increase protein secretion from acinar cells while decreasing fluid and bicarbonate production from ductal epithelial cells. The resulting viscous fluid results in proteinaceous debris becoming inspissated within the lumen, causing ductular obstruction, upstream acinar atrophy, and fibrosis. GP2, which is secreted from the acinar cell and is homologous to a protein involved in renal tubular casts, is an integral component of these ductal plugs.
Lithostathine (formerly called pancreatic stone protein), which also is produced by acinar cells, accounts for about 5% of secretory protein and inhibits the growth of calcium carbonate crystals. Abnormal lithostathine S1, whether inherited or acquired through trypsin digestion, appears to play a role in stone formation; it is insoluble at the neutral pH of pancreatic juice and is the major constituent of pancreatic stones.
A competing theory suggests that the persistent demands of metabolizing alcohol (and probably other xenobiotics, such as drugs, tobacco smoke, environmental toxins, and pollution) cause oxidative stress within the pancreas and may lead to cellular injury and organ damage, especially in the setting of malnutrition. Oxidative and nonoxidative pathways metabolize ethanol. Alcohol dehydrogenase oxidatively metabolizes ethanol first to acetaldehyde and then to acetate. When the alcohol concentration increases, cytochrome P-450 2E1 is induced to meet the metabolic demands.
Although these reactions occur principally in the liver, further increases in ethanol concentration induce pancreatic cytochrome P-450 2E1, and the level of acetate within the pancreas begins to approach that observed in the liver. Reactive oxygen species produced by this reaction may overwhelm cellular defenses and damage important cellular processes.
Although nonoxidative metabolism of ethanol is a minor pathway, the fatty acid ethyl esters produced by this reaction may cause cellular injury and are synthesized in the pancreas to a greater extent than in other organ systems.
Because fewer than 5-10% of people with alcoholism develop chronic pancreatitis, another factor or factors must place these individuals at risk. Researchers have studied genetic polymorphisms of ethanol-oxidizing enzymes, but to date, none have correlated with a susceptibility to alcohol-induced pancreatitis.
A mutation in the gene encoding the serine protease inhibitor, Kazal type 1, has been identified in patients with chronic pancreatitis. The N34S mutation was detected in 5.8% of 274 patients with alcoholic chronic pancreatitis, compared with 1.0% of people with alcoholism without pancreatitis. Although all patients were heterozygous for the mutation, it provides evidence for abnormalities in the pancreatic protease/protease inhibitor system playing a role in the pathogenesis of alcoholic chronic pancreatitis.
Hereditary pancreatitis
Several inherited disorders also are considered metabolic in origin.[8] Hereditary pancreatitis is an autosomal dominant disorder with an 80% penetrance, accounting for about 1% of cases. Research of families with hereditary pancreatitis has led to the identification of several mutations in the cationic trypsinogen gene on chromosome 7. These mutations apparently render the activated enzyme resistant to second-line proteolytic control mechanisms. Mutations were found in the pancreatic secretory serine protease inhibitor Kazal type 1 (SPINK1) gene in 18 of 96 patients with idiopathic or hereditary chronic pancreatitis.
Cystic fibrosis in pancreatitis
Cystic fibrosis, one of the most common genetic abnormalities, is an autosomal recessive disorder accounting for a small percent of patients with chronic pancreatitis. The cystic fibrosis transmembrane regulator (CFTR) gene transcribes a protein important in regulating chloride transport across cellular membranes.
Several hundred mutations of the CFTR gene have been identified, and the clinical manifestation of any given mutation depends on how severely it affects the protein's ability to regulate chloride transport. Different mutations in CFTR are associated with different functional statuses of the exocrine pancreas.
Specific CFTR genotypes are significantly associated with pancreatitis. Patients with genotypes associated with mild phenotypic effects have a greater risk of developing pancreatitis than do patients with genotypes associated with moderate-severe phenotypes.[9]
Idiopathic chronic pancreatitis
This form of chronic pancreatitis accounts for approximately 30% of cases. It has been arbitrarily divided into early onset and late-onset forms. While the cause of idiopathic chronic pancreatitis is not yet known, some evidence points to atypical genetic mutations in CFTR, cationic trypsinogen, and other proteins.
Congenital abnormalities in chronic pancreatitis
Congenital abnormalities, such as pancreas divisum and annular pancreas divisum, are uncommon (even rare) causes of chronic pancreatitis and usually require an additional factor to induce chronic pancreatitis. For example, while pancreas divisum usually does not cause chronic pancreatitis, patients with divisum and minor papilla stenosis are at risk. In these patients, clear evidence of disease exists in the dorsal pancreas, whereas the ventral pancreas is normal histologically.
Acquired obstructive chronic pancreatitis
Acquired obstructive forms typically result from blunt abdominal trauma or accidents involving motor vehicles, bicycles, horses, or, on occasion, severe falls. In these cases, the pancreas is whiplashed against the spine, causing trauma to the ductal system and resulting in a stricture close to the surgical genu. In rare instances, chronic inflammatory conditions affecting the duodenum, or primarily the duodenal papilla, can induce fibrosis and papillary stenosis in a subset of patients, leading to chronic pancreatitis.
Additional causes
Other causes of chronic pancreatitis include the following:
Hyperlipidemia (usually type I and type V) - However, hyperlipidemia usually presents with repeated attacks of acute pancreatitis
Hypercalcemia due to hyperparathyroidism - Now is a rare cause of chronic pancreatitis, probably because automation of serum chemistries reveals hypercalcemia before it results in pancreatitis
Nutritional, or tropical, chronic pancreatitis - Rare in the United States, but an important cause of disease in other parts of the world
Medications - An infrequent, or possibly underrecognized, cause of chronic pancreatitis
Obstruction of the flow of pancreatic juice can cause chronic pancreatitis. Obstructive forms account for less than 10% of cases and may be congenital or acquired.
Based on estimates from hospital discharge data in the United States, approximately 87,000 cases of pancreatitis occur annually.
Comparing the hospital admissions data from several cities around the globe, the overall frequency is similar. Expressed as number of cases per 1000 hospital admissions, the value for Marseille is 3.1; for Cape Town, 4.4; for Sao Paulo, 4.9; and for Mexico City, 4.4. When the data from several centers were compared over time, the incidence of chronic pancreatitis from 1945-1985 appeared to be increasing.
Race-, sex-, and age-related demographics
Hospitalization rates for blacks are 3 times higher than for whites in the United States. In population studies, males are affected more commonly than females (6.7 vs 3.2 per 100,000 population).
Differences in the hospitalization rates of patients with chronic pancreatitis exist with respect to sex. Rates in males peak between ages 45 and 54 years and then decline; female rates reach a plateau, which remains stable after age 35 years.
Sex differences with respect to etiology also exist. Alcohol-induced illness is more prevalent in males, idiopathic and hyperlipidemic-induced pancreatitis is more prevalent in females, and equal sex ratios are observed in chronic pancreatitis associated with hereditary pancreatitis.
In aggregate, the mean age at diagnosis is at age 46 years, plus or minus 13 years. In idiopathic chronic pancreatitis, a bimodal age distribution has been reported, designated as the early onset form (median age 19.2 y) and the late-onset form (median age 56.2 y).
The prognostic factors associated with chronic pancreatitis are age at diagnosis, smoking, continued use of alcohol, and the presence of liver cirrhosis.
The overall survival rate is 70% at 10 years and 45% at 20 years. In an international study, 559 deaths occurred among patients with chronic pancreatitis, compared with an expected number of 157, which creates a standard mortality ratio of 3.6. Taking the opposite view, the 10-year mortality rate is 30%, and the 20-year mortality rate is 55%. The risk of developing pancreatic cancer is approximately 4% at 20 years.
The most common complications of chronic pancreatitis are pseudocyst formation and mechanical obstruction of the duodenum and common bile duct. Less frequent complications include pancreatic ascites or pleural effusion, splenic vein thrombosis with portal hypertension, and pseudoaneurysm formation of the splenic artery.
A pseudocyst is a collection of pancreatic juice enclosed by a wall of fibrous or granulation tissue. It arises as a consequence of acute pancreatitis, pancreatic trauma, or chronic pancreatitis. The clinical challenge is to diagnose a cystic pancreatic structure correctly as a pseudocyst. As many as 5% of cysts are retention cysts, another 5% of these cysts are either congenital in origin or acquired (as in von Hippel-Lindau syndrome), and 10% are neoplastic in origin (mucinous vs serous cyst).
Pseudocysts develop in approximately 10% of patients with chronic pancreatitis. They develop as a result of ductal disruptions rather than from peripancreatic fluid accumulations that lead to pseudocyst formation in the setting of acute pancreatitis. Pseudocysts may be single or multiple and can be small or large, and they can be located either within or outside of the pancreas. Most pseudocysts communicate with the pancreatic ductal system and contain high concentrations of digestive enzymes.
The walls of pseudocysts are formed by adjacent structures, such as the stomach, transverse mesocolon, gastrocolic omentum, and pancreas. The lining of pancreatic pseudocysts consists of fibrous and granulation tissue; the lack of an epithelial lining distinguishes pseudocysts from true cystic lesions of the pancreas. Most pseudocysts are asymptomatic. They can, however, produce a wide range of clinical problems, depending upon the location and extent of the fluid collection.
Expansion of the pseudocyst can produce abdominal pain, duodenal or biliary obstruction, vascular occlusion, or fistula formation into adjacent viscera, the pleural space, or pericardium. Spontaneous infection with abscess formation can occur. (See the images below.)
Digestion of an adjacent vessel can result in a pseudoaneurysm, which can produce a sudden expansion of the cyst or gastrointestinal bleeding due to bleeding into the pancreatic duct (hemosuccus pancreaticus).
Pancreatic ascites and pleural effusion can result from disruption of the pancreatic duct, leading to fistula formation to the abdomen or chest, or rupture of a pseudocyst with tracking of pancreatic juice into the peritoneal cavity or pleural space.
The indications for drainage of pseudocysts include rapid enlargement, compression of surrounding structures, pain, or signs of infection. Endoscopic retrograde pancreatograms may be helpful prior to drainage to rule out a stricture of the pancreatic duct, which can lead to persistent drainage from the pseudocyst.
Bile obstruction and duodenal obstruction
Symptomatic obstruction of the bile duct and/or duodenum develops in 5-10% of patients with chronic pancreatitis. Postprandial pain and early satiety are characteristic of duodenal obstruction, while pain and abnormal liver function test results (including hyperbilirubinemia) are suggestive of a bile duct stricture. These complications are most commonly seen in patients with dilated pancreatic ducts; they are either due to inflammation and fibrosis in the head of the pancreas or are the result of a pseudocyst.
Drainage of an obstructing pseudocyst can be accomplished surgically by gastrojejunostomy or choledochoenterostomy. Endoscopic stenting may be helpful for benign bile duct strictures.
Additional complications of chronic pancreatitis
Diabetes mellitus is a late manifestation in about one third of patients. The tendency to develop ketoacidosis is low.
The presence of the splenic vein at the posterior surface of the pancreas predisposes it to thrombosis from adjacent pancreatic inflammation. Patients who are affected can develop gastric varices as a result of associated portal hypertension. Splenectomy is usually curative for patients who develop bleeding from gastric varices.
Pseudoaneurysm is rare, but it can be a deadly complication. Affected vessels, including the splenic, hepatic, gastroduodenal, and pancreaticoduodenal arteries, are in close proximity to the pancreas. Surgery for bleeding pseudoaneurysms is challenging and associated with high morbidity and mortality.
Vege SS, Ziring B, Jain R, Moayyedi P, for the Clinical Guidelines Committee. American Gastroenterological Association Institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology. 2015 Apr. 148(4):819-22. [Medline].
Kaufman M, Singh G, Das S, Concha-Parra R, Erber J, Micames C, et al. Efficacy of endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis for managing abdominal pain associated with chronic pancreatitis and pancreatic cancer. J Clin Gastroenterol. 2010 Feb. 44(2):127-34. [Medline].
Gadroy FX, Ponchon T, Roda R, et al. Endoscopic treatment of chronic pancreatitis: long-term results. Gastrointest Endosc. Apr 2006. 63(5):AB312.
Cahen DL, Gouma DJ, Nio Y, et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med. 2007 Feb 15. 356(7):676-84. [Medline].
Büchler MW, Martignoni ME, Friess H, Malfertheiner P. A proposal for a new clinical classification of chronic pancreatitis. BMC Gastroenterol. 2009 Dec 14. 9:93. [Medline]. [Full Text].
Pezzilli R. Etiology of chronic pancreatitis: has it changed in the last decade?. World J Gastroenterol. 2009 Oct 14. 15(38):4737-40. [Medline]. [Full Text].
Kawa S, Hamano H, Ozaki Y, et al. Long-term follow-up of autoimmune pancreatitis: characteristics of chronic disease and recurrence. Clin Gastroenterol Hepatol. 2009 Nov. 7(11 Suppl):S18-22. [Medline].
Schmitt F, Le Henaff G, Piloquet H, et al. Hereditary pancreatitis in children: surgical implications with special regard to genetic background. J Pediatr Surg. 2009 Nov. 44(11):2078-82. [Medline].
Ooi CY, Dorfman R, Cipolli M, et al. Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis. Gastroenterology. 2011 Jan. 140(1):153-61. [Medline].
Tezuka K, Makino T, Hirai I, Kimura W. Groove pancreatitis. Dig Surg. 2010. 27(2):149-52. [Medline].
Saftoiu A, Popescu C, Cazacu S, et al. Power Doppler endoscopic ultrasonography for the differential diagnosis between pancreatic cancer and pseudotumoral chronic pancreatitis. J Ultrasound Med. 2006 Mar. 25(3):363-72. [Medline]. [Full Text].
Kalb B, Martin DR, Sarmiento JM, Erickson SH, Gober D, Tapper EB, et al. Paraduodenal Pancreatitis: Clinical Performance of MR Imaging in Distinguishing from Carcinoma. Radiology. 2013 Nov. 269(2):475-81. [Medline].


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Topic: WPP
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With Indiana's governor ailing, court transfers power
INDIANAPOLIS -- As Gov. Frank O'Bannon lay in critical condition following a stroke, the state Supreme Court formally transferred power Wednesday to Indiana's lieutenant governor.
Legislative leaders filed a petition to transfer power after receiving a written statement from O'Bannon's doctor and invoked a process spelled out in the state constitution for officially handing power to Lt. Gov. Joe Kernan.
"We are making historical precedent here today. We wanted to make sure, absolutely sure, the family was in agreement. The doctors were in agreement," said Democratic House Speaker Patrick Bauer, who joined with Republican Sen. President Pro Tem Robert Garton to file the petition.
"I want to emphasize, Gov. O'Bannon is still the governor of Indiana, and Judy O'Bannon is still the first lady of Indiana," Garton said.
Doctors said O'Bannon, 73, had emerged from a drug-induced coma, but was under sedation and showed some "small but significant improvements."
He remained in critical condition.
O'Bannon responded to commands to wiggle his toes and some physical stimulation, doctors said.
"At this early going, making long-term prognostications is really, really difficult," Dr. Hunt Batjer said.
The governor's wife, Judy, issued a statement saying she was comfortable with the formalized power transfer. Legislative leaders had said they wanted the family's approval before proceeding.
"We are aware of the formal process that is occurring in Indiana, and in it we are seeing what we have always known: Our state government is a strong institution based on a constitution," Judy O'Bannon said.
Justices met privately for about an hour before issuing their decision. Chief Justice Randall Shepard said state officials acted on what they believe the governor would have wanted.
"We know what he wants and expects of us -- to be at our posts and act in the way that the people of Indiana expect under this situation," Shepard said. "We do our best to do that, however heavy our hearts are about what has happened to him."
After the order was issued, Shepard joined more than 500 people in the Statehouse rotunda for an interfaith service.
As acting governor, Kernan attended a forum to promote an economic development package he and O'Bannon pushed through the General Assembly this year.
O'Bannon, a Democrat in his second term, was found in his pajamas, unconscious and near death, on the floor of his Chicago hotel room Monday morning. He had gone to the city to attend an economic conference. He had suffered a type of stroke that involves bleeding in the brain.
Kernan earlier became acting governor under a provision in the state constitution that allows him to temporarily carry on business without a formal transfer of power.
On the Net


text:
Hotel de la Pinède, Antibes
- Free WiFi
Main amenities
- 12 guestrooms
- Near the beach
- Breakfast available
- Terrace
- Daily housekeeping
- Limited hour front desk
- Tour/ticket assistance
What's around
- In Juan-les-Pins
- Juan-les-Pins Beach (0.5 mi / 0.8 km)
- Pinede Garden (0.1 mi / 0.2 km)
- Juan les Pins Palais des Congres (0.3 mi / 0.5 km)
- Provencal Market (1.4 mi / 2.2 km)
- Picasso Museum (1.4 mi / 2.2 km)
For families
- Terrace
- Daily housekeeping
- Hair dryer
- Satellite TV service
- Free parking nearby
Hotel de la Pinède, Antibes
Hotel Info: 866-539-8117from $71
- Economy Double Room (10m² sans climatisation)
- Single Room
- Family Suite
- Economy Double Room (10m2)
- Comfort Double Room
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 12 rooms
- This hotel is arranged over 2 floors
- Check-in time 3 PM-6 PM
- Check-out time is 11:30 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Free nearby parking
Nearby Two Star Antibes hotels
In the hotel
- Continental breakfast daily (surcharge)
- Front desk (limited hours)
- Tours/ticket assistance
- Number of buildings/towers - 1
- Year Built 1881
- Designated smoking areas (fines apply)
- Terrace
In the room
- Soundproofed rooms
- Individually decorated
- Partially open bathroom
- Shower only
- Hair dryer
- Satellite TV channels
- Free WiFi
- Phone
- Daily housekeeping
Top Antibes hotels
Recently reviewed hotels in Antibes
- Hôtel Barrière Le MajesticFrom
"The hotel was very nice. Loved the bar. Service was great as well. "Jun 18, 2016
- Park Inn by Radisson Nice Airport HotelFrom
"We stayed twice before at this hotel because it's convenient to the airport and you can have a nice breakfast buffet and/or dinner at the pool. Also, nuce staff. The only problem…"Jun 17, 2016
- Villa RivoliFrom
"We had a very nice three day stay at this hotel, despite the fact that the airline lost my luggage for a week and we had to keep calling them to see if there was any news. But…"Jun 16, 2016
- ParisienFrom
"The staff was friendly and the room was ok. Location very convenient. "Jun 15, 2016
Nearby hotels
Hotel de la Pinède, Antibes's small print
Also known as
- de la Pinède Antibes
- Hotel de la Pinède
- Hotel de la Pinède Antibes
Noise-free guestrooms cannot be guaranteed.
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 0.85 per person, per night
Optional extras
Parking is available nearby and costs EUR 8 per night
Continental breakfast is offered for an extra charge of EUR 10 per person (approximately)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text:
Wake (Mass Market Paperbound)
Usually Ships in 1-5 Days
A Hugo and Nebula Award-winning author joins Ace with a stunning new science fiction epic.
Caitlin Decter is young, pretty, feisty, a genius at math, and blind. When she receives an implant to restore her sight, instead of seeing reality she perceives the landscape of the World Wide Web-where she makes contact with a mysterious consciousness existing only in cyberspace.
About the Author
Robert J. Sawyer is the author of "Flashforward", winner of the Aurora Award and the basis for the hit ABC television series. He is also the author of the WWW series "Wake", "Watch" and "Wonder" "Hominids", "Calculating God", "Mindscan", and many other books. He has won the Hugo, Nebula and John W. Campbell Memorial awards making him one of only seven writers in history to win all three of science-fiction s top awards for best novel. He was born in Ottawa and lives in Mississauga, Ontario.


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Palomino mare maiden w size, beauty, gait. Silver mane & tail. good straight face. Star & one sock .Owner is aging & retiring.$4,500
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Our experience was excellent. The setting is rustic and dated. Rooms were Clean, Comfortable and Adequate. Dining (Ballroom Convention Area) was average, tasty & abundant!! The staff was helpful, courteous and well trained. Room & food prices were moderate. Although he address is Virginia Beach it is about 15 miles form the waterfront. Not to worry they have a spa, pool,( Indoor & outdoor) overlooking a lovely lake. You will not be disappointed!!!
- Reservation Options:
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text:
Liberty of the Seas Cruise Review by MARK18: Incredible European Cruise with a few issues
Overall Member Rating
Incredible European Cruise with a few issues
Destination: Europe - Western Mediterranean
Embarkation: Barcelona
Just off a 7 day Med cruise from Barcelona on the Liberty of the Seas. First off, the ship is gorgeous, well maintained, with plenty of activities to keep everyone satisfied.
CABIIN: We stayed in balcony cabin on deck 9 towards the aft end. Great room, great location, and very quiet. The cabin attendant, Marlon, was always there to open the door before we could take our key out. It was uncanny. He kept the room spotless. 10/10
ENTERTAINMENT: We saw all the shows and were very impressed. There was a technical issue during Saturday Night Fever and they seamlessly fixed it. All the singers and dancers we saw were excellent. 10/10
TOURS: We used only the ship tours. Yes, they are expensive, but it's worth every penny for peace of mind if any issue occurs. Most impressive was our guide out of Naples, Enzo. He took us back in time to Pompeii with such an incredible narrative, I thought I was alive 2,000 years ago. All the guides spoke English well and gave us More great information about the destination. 10/10
DINING: We ate in every venue of the ship. The two specialty restaurants were excellent. I had a porterhouse in Chops that was superb, while my Filet Mignon in Portofinos could be cut with a fork. The food in Sorrento's (the pizza place) was good, not great. I did like the duck pate. As for the rest, it was all mediocre at best. The Windjammer was served burned burgers and stale buns, while the selection at Jade included sushi similar to what I get at my local grocery store. The main dining room was embarrassing. I could have used my duck to play basketball with since it was so rubbery. The giant shrimp I had was also ready to be bounced off the floor. There sad part is the selections was so poor I didn't even bother to get another item. I must admit the red cabbage was pretty good. 4/10
Service: The service on board was outstanding. Everyone was so nice, we couldn't ask for anything more. From our room attendant, to the dining staff, to the bartenders (hello to Steve in the Olive & Twist) everyone exceeded our expectations. 10/10
OVERALL: With the exception of the food, this was the ideal cruise. I totally understand that it really isn't feasible to feed that many people and provide top quality food. For this reason we will go to back to the smaller ships or an upscale cruise line to get the food we like. Less
Published 10/16/12
Read more Liberty of the Seas cruise reviews >>
Read Cruise Critic's Liberty of the Seas Review >>
Cabin review: D19676 Superior Oceanview Stateroom with Balcony
Read All Superior Oceanview Stateroom with Balcony (D1) Reviews >>
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Canon 5D still worth buying?
Started May 18, 2014 | Discussions thread
Shop cameras & lenses ▾
SanjayNair OP • Junior Member • Posts: 27
Re: From bad idea to worse idea
In reply to darklamp • May 18, 2014
This decision makes me wonder if you even read the advice you were given ( mostly against ) when you suggested moving to a D700 from a D5000.
Whatever advice was given in relation to moving to a D700, moving to an original 5D is certainly not a better idea.
I do remember that. Just that I found a good offer and wanted to know if this would be good,especially because 5D is still considered to be very capable at the highest order.optical wise. Thanks anyways.
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Kevin Fletcher threw the football around once in a while as a way of relaxing and relieving stress when he was stationed in Afghanistan in 2010 and 2011.
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Shares of industrial conglomerate United Technologies Corp (UTX.N) may be poised for double-digit increases over the next year to 18 months as its acquisition of Goodrich pays off and other businesses rebound, financial newspaper Barron's said.
Goodrich is expected to add 55 cents a share to 2013 earnings, the article said.
Citi Research analyst Deane Dray, who is quoted in the article, sees United Technologies shares gaining 18 percent this year to $110. Its shares closed at $92.64 on the New York Stock Exchange on Friday.
United's Otis elevator unit and the security and fire prevention businesses also are placed to make meaningful contributions this year, helped by overseas expansion, Barron's said in its April 8 edition.
With a $2.14 per share dividend, a share buyback program and earnings that could rise 15 percent this year, United Technologies shares are looking like a good bet, the article said.
(Reporting by Bill Berkrot; editing by Jane Baird)
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text: Poesia americana. 1900 - 1999 Amerikaanse letterkunde. Amerikai irodalom vers. Poetry, American. Poetry. Collections. A collection of poetry by one of the best known poets in the United States including "The Gift Outright" which was read at the inauguration of President John F. Kennedy. New enlarged anthology of Robert Frost's poems Robert Frost's poems. With an introduction and commentary by Louis Untermeyer. [Illustrated by John O'Hara Cosgrave II] Poems Poems Robert Frost's poems : /with an introd. and comment. by Louis Untermeyer Biography Fo luo si te shi xuan Containing all of Robert Frost's best-known poems--including "Birches, " "Mending Walls, " and "Stopping by Woods on a Snowy Evening"--And dozens more--this collection celebrates the New England countryside, Frost's appreciation of common folk, and his understanding of the human condition. Poems Poëzie Robert frost's poems 佛洛斯特詩選 Robert Frost's poems Robert Frost's poems American poetry. American poetry 20th century. Poets, American.


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Ocean Springs Type C Motor Homes for sale
Class C Motorhomes, occasionally associated with the mini style motor home, provides the amenities of the bigger Motorhomes RV in a reduced edition and at a more modest price. The Type C recreational vehicle (RV) is constructed on an automotive fabricated van chassis with a connected cab section. The size of a Class C Motorhome varies from nineteen to twenty-eight feet. The Class C (mini) Motorhome RV allows a lot of the luxuries and amenities of the Class A RV in a reduced and lower priced unit. It possesses sizeable living space and at-home comforts, and represents perfectly flexible accommodation for weekend escapes or extended vacations.
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Skip to comments.Fox news off the air here. (comcast)
Posted on 02/01/2010 7:30:55 AM PST by WhirlwindAttack
I was watching Fox news and as they were starting a story ob 0bama gearing up missile defense in the gulf the screen blanked at 9:56 AM. I've got Comcast. PMSNBC, and CNN are working fine here. I lost selective channels not all of them
It took 11 minutes to finally load Free Republic.
Is this happening to anybody else out there?
Freegards and sorry for the vanity
Everything is going down..it is all.. collapsing..... look outside... oh my ...........
Fine here on Comcrap (PA). You have a local problem.
NO. I am watching Fox News. No interruptions.
Didn't Comcast just buy out NBC or MSNBC - maybe that is the problem?
I'm having problems too getting Freerepublic to load. Keep getting timeouts and when I am able to get it to load it's very slow.
It sounds like a local glitch.
Well, here in Santa Barbara, CA and FOX is on the air.
watch foxnews on the web
Taking down FR by DOS or other means would be an utterly stupid, and doomed tactic on the part of the government. They would get caught, and the furor would be bigtime polically unfavorable.
Free Republic (IP also Comcast) runs like a three legged horse, if it loads at all.
We are on Cox here in Connecticut. I've had trouble on and off for the last several days getting FR to load. It's the only website that I've had problems with. Everything else is just fine.
Fox News is off here too. Other news channels are on. Fox News seems to be only channel off for me.
Back when debate was going on about Cap and Trade, I lost satellite connection to FOX and CSPAN. It might have just been a strange coincidence, but the connection on CSPAN seemed to be fine when the person voting for Cap and Trade wanted to speak. There weren't any storms or anything outside either.
I have dish network
I have comcast also, but I didn't have any interruptions with Fox today. There have been several occasions in the past that, for whatever reason, Fox has gone blank while all other channels work fine. I've found when this happens, if I change the channel from Fox and then right back to Fox, it starts working again. No idea why and I've not noticed the same problem with any other channel.
If you go to the COMCAST news section "On Demand"...you will NOT find Fox News listed...only CNN and a local news channel.
Dish Network
I lost FOX at 3:45am PST today with Broadstripe
No Comcast interruptions here. Obozo is on FOX running his mouth about something right now.
Are you logged in?
You are not missing much.
He's changed the word from spending to investing.
Got it!
LOL.........we are not buying his bull.
A few days ago FOX and several other networks were off the air on my standard cable but I never lost them on the digital channels.
I've got the rest of the lame stream media. All the fox news channels are off air here. Very strange.
Well thanks everybody.
Are you kidding me? Are you so paranoid that a simple cable outage becomes part of the conspiracy?
Wow. Cut down on the decaf. Call Comcast. And get outside and get some sunshine.
And yes, do not forget to take the pills this morning.
Correction ALL fox channels are off here.
Fox is on in SoCA.
Same thing happened a few days ago here south of Tucson. Heard a helicopter circling and checked to see if it was black, but it was just the usual green & white border patrol. Also, the local grocers still had an ample supply of tinfoil, so I figured move along, nuthin here......
There was a running thread about this a couple of hours ago; it appears you're far from alone....but personally I've had no problem with FR this morning.
Fox News ok here in South Carolina.
Its not the black helicopters you gotta worry about, its the white NHL choppers that are a real threat.
Don't want to miss this screaming rant at a city council meeting.
No problem with fox but FR was slow to load.
We swtiched to DirecTv because Dish would not carry the Fox Business channel.
I'm in Tn. as well. It's due to the cold, snow and ice.
Did your spouse use parental controls to block it? ;-)
Comcast is great here. The fastest internet connection I've ever used.
Where is "here"?
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Current time: 0:00Total duration: 6:54
0 energy points
Elasticity and strange percent changes
Why we calculate percent changes in a strange way when calculating elasticities. Created by Sal Khan.
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text:
Researchers Now Have a Myriad of...
Co-Sourcing Improves Pharmaceutical Laboratory Productivity
Keep the Opportunities, Lose the Opportunists
Loss of Lives in Clinical Trials...
Researchers at Dana-Farber Cancer Institute identified a master switch in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating.
Brown fat is controlled by a gene and protein known as PRDM16 that is not in white fat. In the study, the investigators inserted the PRDM16 genes into precursors of white fat, which were then implanted under the skin of mice. They found that the PRDM16 gene coaxed those cells to generate brown fat cells.
Further analysis showed that PRDM16 triggered the formation of brown fat cells in part by turning on a metabolic pathway controlled by proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and the gene UCP1, which allows cells to release large amounts of energy as heat.
The research is published in the July issue of Cell Metabolism.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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(Nov. 12, 2009)--UTSA students, faculty and staff are invited to a special event, "Celebrate UTSA! All Different. All Roadrunners," from 5 to 8 p.m., Wednesday, Nov. 18 in the University Center paseo on the Main Campus. A performance by country singer David Bradley will be at 6 p.m.
The event will include an onstage showcase with performances, readings and speeches, along with information on UTSA student organizations, services and departments. The festivities are free and open to the UTSA community.
Ethnic foods will be served, along with the opportunity to enjoy interactive programs, prizes, and other fun and educational activities. Food and other giveaways and t-shirts will be free and available while they last. In the case of rain, the event will move to the University Center Ballroom (1.104).
To sign up to host an information table, to participate in the showcase or for more information about the event, contact Ann Margaret Trujillo, Inclusion and Community Engagement Center, at (210) 458-4770.
Read more about Diversity Month at the UTSA Inclusion and Community Engagement Web site.
The UTSA Interactive Technology Experience Center camps are for curious youth who are interested in STEM and related topics. This week, campers will study environmental science, robotics and computer science.
UTSA Main Campus
In four sessions of this weeklong day camp for 9 to 13-year-olds, campers will participate in indoor and outdoor activities while exploring ancient technologies from around the world and the new technologies archaeologists are using to discover them.
UTSA Center for Archaeological Research, Main Campus
Campers will investigate how museums use artifacts, oral histories, and research to unravel stories about our past.
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UTSA Math faculty prepare participants for success in their future math courses.
UTSA Main Campus
Staff can help campers improve their technical skills and knowledge of the game while having fun.
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An opening reception is being held for the exhibit "Girl's Eye View" which was produced by students who documented life on San Antonio's East Side with photography, poetry and film.
UTSA Institute of Texan Cultures
Experience a very different summer camp! The UTSA East Asia Institute is teaching kids Japanese through language, culture, art, crafts, music, cooking and more. For kids age 6-12. For more details, email email@example.com.
Main Building (MB 1.126), Main Campus
7 to 12 year-olds will explore Mayan Culture in a three-day sessions, concluding at the Witte museum, where campers will have the chance to see the new "Maya: Hidden Worlds Revealed" exhibit.
UTSA Center for Archaeological Research, Main Campus
Other Calendars
» UTSA Events | » Academic | » Institute of Texan Cultures
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.


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Media Inquiries 336-716-4587Patient Information 336-713-0000Satellite Interviews 336-716-4434
Bedwetting Can be Due to Undiagnosed Constipation, Research Shows
Wake Forest Baptist is committed to providing quality care and a safe hospital environment.
Summer increases everyone's risk of heat stroke and sunburn, but there's another warm weather risk that often flies under the radar—kidney stones.
Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.


text: No recent wiki edits to this page. Aunt May is making secret trips to the parts of Brooklyn where she spent her adolescence. Peter discovers that she has been receiving letters from a former suitor, Johnny Jerome, who has been recently paroled from prison. It's a touching story about days gone by.


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Bengali-speaking Muslims to be rehabilitated from Oct 19Prabin Kalita | TNN | Oct 11, 2012, 12.02 AM IST
GUWAHATI: The rehabilitation of land-owning Bengali-speaking Muslims displaced from the Bodoland Territorial Area Districts (BTADs) of Kokrajhar and Chirang during the recent ethnic conflict with the Bodos will finally start from October 19. This was decided at a meeting between the group of ministers (GoM) appointed by the state government to look into rehabilitation and Bodoland Territorial Council (BTC) administrators on Wednesday.
An official source said, "Altogether 19,632 families of the Bengali-speaking Muslim community from Kokrajhar and Chirang districts have been found to be genuine land owners in the BTAD after scrutiny of their land documents. Their rehabilitation starts from October 19."
The rehabilitation would, however, be only for those Bengali-speaking Muslims who have land holdings in the two BTC districts and were uprooted in the clashes. The Bodoland People's Front-ruled BTC has made land ownership the primary criteria for rehabilitation and has conveyed to the state government that those without land holdings will not be accepted back in BTAD.
Other Bengali-speaking Muslims, who were also displaced but do not have any land holdings in the BTAD region and were living on government land and grazing grounds when the clash started in July will continue to live in relief camps for the time being. The state government has convinced the BTC that an alternative formula has to be worked out to rehabilitate these Bengali-speaking Muslims. "Today, the GoM gave a draft formula to BTC. This will be finalized by October 12," an official source said.
According to the state revenue department, there are 1,59,027 inmates in 187 relief camps across the four BTC districts of Kokrajhar, Dhubri, Chirang and Bongaigaon. Of these, 9,960 inmates are from the Bodo community and the rest 1,49,067 are Bengali-speaking Muslims and other communities. Of these, 9,355 Bodos and 41,206 Bengali-speaking Muslims are in Kokrajhar and are staying in 40 different camps. In Chirang, there are 605 Bodos and 15,332 Bengali-speaking Muslims in 19 camps while in Dhubri, all the 126 camps have only Bengali-speaking Muslim inmates - 91,070 of them. There were 4,85,921 relief camp inmates reported at the peak of the conflict in all the four districts.
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Winners of the 2016 FAI Young Artists Contest Revealed
Tuesday, 26 April 2016 12:14
The FAI international jury selected the winning paintings of the 2016 FAI Young Artists Contest, a competition which every year honours the best paintings from youngsters in three age categories from 7 to 16 years old.
Germany's Dolderer wins Red Bull Air Race in Spielberg, Austria
Sunday, 24 April 2016 17:00
Germany's Matthias Dolderer beat the elements, the obstacles and 13 of the world's best pilots to become the first German ever to win a Red Bull Air Race event at the second stop of the 2016 season in Spielberg, Austria.
Solar Impulse 2 took off to continue world circumnavigation and breaking records!
Thursday, 21 April 2016 19:05
Swiss pioneers and ambassadors for clean technology, Bertrand Piccard and André Borschberg, left the Kakaeloa Airport in Hawaii at 6:15am Hawaiian time to continue their spectacular journey of the first ever solar flight around-the-world. The next days will see the completion of the pioneering adventure as the Solar Impulse 2 (Si2) heads back to its starting point to Abu Dhabi.
Fribourg ready to welcome the famous Gordon Bennett Cup
Wednesday, 23 March 2016 11:27
61st Aeronautical Cup for Gas Balloons in 2017
The Canton of Fribourg will have the honour of organising the prestigious Aeronautical Cup for Gas Balloons, the 'Gordon Bennett' (FAI World Long Distance Gas Balloon Championship) in 2017. In Spain last weekend, the FAI Ballooning Commission (CIA) (which runs the FAI's ballooning activities) confirmed the choice of Fribourg. It adopted the proposal made by the National Ballooning Commission (FSA) back in November 2015. This international competition, which brings together the world's best balloonists, will take place near the airstrip in Epagny, just below the Château de Gruyères and amongst the foothills of the Alps. The event will run from 7 to 16 September 2017. For 'four cornerstones of the Fribourg economy' a dream will come true.
6 months until the 60th Coupe Aéronautique Gordon Bennett in Gladbeck, Germany!
Tuesday, 15 March 2016 17:13
180 days to go until the 60th edition of the Coupe Aéronautique Gordon Bennett, the FAI World Long Distance Gas Balloon Championship. This year the individual stories of the pilots full of adventure, skill, courage, survival and luck will continue in Gladbeck (GER) from 15 – 24 September 2016.
Swiss Pilot Jacques-Antoine Besnard wins 3rd FAI European Hot Air Airship Championship
Thursday, 10 March 2016 16:31
Swiss pilot Jacques-Antoine Besnard wins the 3rd FAI European Hot Air Airship Championship in Rottach-Egern (GER) before the two Germans Andreas Merk and Ralph Kremer. The European Championship took place from 24 - 29 February 2016 in the beautiful Tegernseer Valley in Bavaria, Germany.
FAI at the Red Bull Air Race
Saturday, 12 March 2016 19:06
FAI President Dr. John Grubbström was in Abu Dhabi at the Red Bull Air Race on Saturday 12 March 2016 – and met up with the General Manager of the Red Bull Air Race Erich Wolf.
Nicolas Ivanoff of France wins wild season opener in Abu Dhabi
Saturday, 12 March 2016 16:21
The first race of the 2016 Red Bull Air Race World Championship was even hotter than expected in sizzling Abu Dhabi on Saturday, as Nicolas Ivanoff of France blazed through the pylons to victory in a close and frequently astonishing competition.
Red Bull Air Race 2016: Erich Wolf
Saturday, 12 March 2016 13:20
We speak to Erich Wolf, General Manager of the Red Bull Air Race. As General Manager he's responsible for the whole event across eight countries. He's been in charge since 2011, and brought the Red Bull Air Race back in 2014 after a three year hiatus.
Sweden's Daniel Ryfa claims Challenger Class season opener in Abu Dhabi
Saturday, 12 March 2016 13:02
The ninth season of Red Bull Air Race action at Abu Dhabi's Corniche took off with a win for Challenger Class pilot Daniel Ryfa of Sweden. The most experienced contender in the six-man Abu Dhabi field, Ryfa clocked a sizzling time of 1:06.308.
Polish pilot Czepiela blazes into Challenger Class season with top Qualifying time
Friday, 11 March 2016 17:21
With less than 24 hours to go before the ninth consecutive season opener of the Red Bull Air Race in Abu Dhabi, pilot Luke Czepiela of Poland got a fast start to the season with a top Qualifying time of 1:07.241 seconds in the Challenger Class.
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High resolution photograph of the Miami Skyline – view from Key Biscayne. Royalty Free image.
Image updated—30/03/2013
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Austin, TXUSA
January 24, 2013
Originally from Austin, TX. Now live in Cedar Park with my husband Billy and our two Vizslas, Copper & Linkin. These are our 2nd and 3rd of the breed, and we just LOVE these dogs!
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Infrastructures and Logistics
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European commission
Our Organisation
Our Organisation
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Reference Documents
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Our Organisation
The Office for Infrastructure and Logistics, Brussels, was created by a
Commission decision of November 6, 2002
The mission of OIB is to ensure the implementation of all actions connected with the
of personnel, the management of
social infrastructure
and the
of the institution in Brussels as well as
social infrastructure on the Ispra site
of the Commission in Italy.
OIB's aim is to ensure a functional, safe and comfortable workplace for all those working for the Commission, and to provide good quality support and well-being services, based on a client-oriented approach, in an environmentally-friendly and cost-effective way.
In particular, responsibilities include :
to manage the purchase, rental and maintenance of the movable and immovable property of the Commission, as well as inventories and VAT questions related to them,
to organise relocations and to manage space,
to manage:
the transport of staff and of equipment according to internal requirements,
the reception and distribution of mail and the internal distribution of documents for the Directorates-General and other departments of the Commission,
graphic reproduction services,
office supplies,
the historical archives,
to manage the social facilities placed at the disposal of the personnel of the European institutions including restaurants, cafeterias, shops, sports centres, etc.
to provide certain social services to the institutions such as creches or after school child-minding services
to ensure the occupational health and safety of Commission staff through prevention and protection measures.
Organisation of OIB
The Office is managed by:
Marc Mouligneau: Director of the Office
organisation chart of OIB
(16 Kb)
There are four departments in OIB:
Resources (Head of Department: Marc Mouligneau (acting))
Informatics Resources
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Implementation of buildings policy
Technical Services, Building Management
Property Projects
Operations and Services (Head of Department: Erik Halskov)
Historical Archives
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Support Services, Logistics
Social Infrastructure - Ispra
Childcare facilities (Head of Department: Christiane Bardoux)
Child-minding facilities, CIE
The activities of the office are supervised by a management committee, under the authority of the member of the Commission responsible for human resources and security. The management Committee is chaired by the Director General of DG Human Resources and Security (DG HR).
The staff of the Office is subject to the same staff regulations and the same internal rules as other staff working for the Commission. Rules and internal procedures apply to OIB in the same way as they apply to other DG's and services of the Commission.
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Slovakia will hold the Presidency of the Council of the European Union from 1 July to 31 December 2016.
Join the European debate
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Professor Mom
Chronicles the life of a mom, teacher, and writer trying to stay sane amid the chaos of daily life.
January 13, 2010
Hole Punch Name Craft
Kids love writing their names on things. I have more than a few books from my childhood with giant messy Allisons written all over them. Avoid the defacing of good books and make this craft instead! Punching all the paper holes uses up scrap paper too!
1. Gather your materials. You will need a sheet of construction paper, some glue, scrap paper in many colors, and a hole punch.
2. Start by punching as many holes as you can!
3. Get a good mix of light and dark colors.
4. Using the glue write your child's name, or have them write it in glue.
5. Sprinkle them on!
6. Let dry and shake off the excess.


text:
I wanted to ask, how I can change the Input of the left sidebar. I need only one page with a long long text with different chapters. I want the sidebar to be a menu, which is not switching between different sides, it should jump to special points in the Text. Just like the wikipediamenu.
The html-tag is simple with

 and
, but I am not sure, how I can add it to the left sidebar. Any Ideas?
Thanks for your help


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The Career Center does not hold Express Advising during the summer. We will return to normal Express Advising hours starting in Fall 2016.
During the Fall and Spring semesters, the Career Center holds daily Express Advising Hours for resume and cover letter review or other career-related questions.
Monday, Tuesday, Wednesday: 2:00 pm - 4:00 pm
Thursday, Friday: 10:00 am - 12:00 pm
Express Advising Hours are on a first-come, first-served basis and are limited to 15 minutes.
No appointments are needed for Express Advising. Express Advising Hours are not held during Fall or Spring break.
Spring Semester Express Advising Closures/Exceptions:


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Sorry, we don't currently have event tickets available for The Kennedy Center - Eisenhower Theater.
Star This Venue to find out when new events are added
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263 The Kennedy Center - Eisenhower Theater Tips
- Casual 2
- Formal 1
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- Parking is expensive 4
- Take public transit 2
- Dine before you go 1
Park next door to Kennedy Center for just $12 or $13 - two parking garages available.star this tip starred
Parking is $23. Park around GW and take the shuttle if you can.star this tip starred
If going at night, park in the Watergate for half the price of the Kennedy Center. Or take the Metro to Foggy Bottom and get the free red bus to the Kennedy Center just at the top of the stairs of the Metro.
Bright Starstar this tip starred
Seats in Eisenhower theater crampt in balcony but you can see well as properly elevated between rows.star this tip starred
Kennedy Center does not assign seates. You'll get them at the box office when you arrive.star this tip starred
Parking at Kennedy Center is $23.00 per vehicle. Expensive. Remember where you parked. It took us 15 minutes to find our car. Note floor, section, row number.star this tip starred
The weather was 65. I wore Dress.star this tip starred
Parking Near The Kennedy Center - Eisenhower Theater
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- Grouping and Descriptive Categories (36)
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BGINFO4X - BGINFO for X and for Windows!
Shows desktop information on your screen117 weekly downloads
CYGNIX means "CYGnus pseudo-uNIX". It is a pseudo-UNIX environment based on CygWin. It's tiny and not meant to be a full featured CygWin developing environment. CygNix is ideal for Unix users who sometimes have to do some routine works on Windows.1 weekly downloads
Cygwin RPM
RPM (RedHat Package Manager) and a collection of GNU / freeware tools in RPM format for Cygwin Posix emulation layer (http://sourceware.cygnus.com/cygwin) for Windows 95/98/NT/200028 weekly downloads
Cygwin-Lite Minimal Cygwin Environment
Cygwin-lite is a subset of the Cygwin tools plus a HTML User's Guide (see homepage), designed for people new to GNU software, especially bash. The self-executable installer fits on a 1.44MB floppy disk.8 weekly downloads
DMZS-Biatchux Bootable CD Distro
Bootable CD Forensics/Virus Scanning/Recovery/PenTesting platform8 weekly downloads
Dutch MOO Core
This is a Dutch translated version of LambdaMOO, with a few things extra. A MOO is an Object Orientated virtual World.
Eisti GroupWare
Eisti GroupWare, a software development GroupWare application. It includes a UML designer (can import .java files and export xml content), a built in chat system, and a distributed repository system. Writen in java - C, in french for our school project a1 weekly downloads
Fast2Share P2P System
Fast2Share is a decentralized hybrid system that enable clients to share files with other ones. It uses artificial intelligence to improve search results and to improve the logical topological distribution of servers and clients. All together makes a neve
Feisty Meow® Concerns Codebase
Codebase of Feisty Meow® Concerns Ltd.1 weekly downloads
File Merge
Allows you to hide one file inside another1 weekly downloads
A Folding@Home integrated monitoring environment, designed for Linux, *nix systems and Windows, which is intended to be easy-to-use and provide a flexible, customiseable and "user-friendly" environment for reviewing the status of active F@H clients.1 weekly downloads
GNet Server
GNet Server - Network compression client/server software. Compresses data over slow networks to save on the cost of bandwidth. Server is developed for Unix and Windows platforms, The client will run on Windows based PCs.2 weekly downloads
GUI Front End for CVS
CVSGI (Concurrent Versions System Graphical Interface) is a Java based GUI application which works with the CVS archiving system. CVSGI GUI acts as an interface between the user and the CVS system.1 weekly downloads
A Web Based Golf statistic site using PHP. Players can register and input their golf stats per game. Each player is ranked in each category, and players can compare stats with each other. Course and hole stats are also calculated and displayed in graphs.1 weekly downloads
HWUT - The Hello-Worldler's Unit Test
Software Unit Tests (Language Independent Approach)4 weekly downloads
MAG Server
MAG Server stands for Monitor And Graphing Server. [VM Appliance]2 weekly downloads
MOO - Generic IRC Room
This is a generic IRC Room, written to be used in a MOO. (Multi User Dungeon Object Orientated.) With this room, you could connect to an IRC server, somewhere on the Internet.
Open CD Server
The Open CD Server project shares CD-ROM's on a heterogenous network. It is a GPL'd viable alternative to current software, thin-server, and CD Jukebox solutions. It is software based, and uses a web interface for easy administration.2 weekly downloads
Open Src Draft Simulator
The goal of this project is to develop a simulator for the drafts of professional sports leagues.1 weekly downloads
PW32 the Posix-over-Win32 layer
PW32 is primarily C runtime library for Win32 aiming to POSIX compliance. Its main concerns are effeciency and support even for low-end Win9x systems. LGPL. Also, PW32 is collection of ported software, aiming to be GNU (etc.) distribution for Win32.1 weekly downloads
Quality Management software package
Quality Assurance & Control database client server system. Postgresql server, C# clients, web php interface. All strategies are ISO 9001: 2000 compliant.Solve almost all traceability requierements.3 weekly downloads
React X
A free Win32 DirectX implementation for ReactOS and OpenROS
Sherman is a tool designed to aid in the deployment of Win9x workstations and software within an organization. The linux-based bootdiskallows for the unattended installation of Win9x, while the client provides basic software packaging services.1 weekly downloads
SoupToNuts: articles and software
SoupToNuts is a repository of technical articles and example software covering Postfix, OpenSSH, C and C++, Live Linux CD, MySQL, SQLite, Berkeley DB, Bash and System Administration.71 weekly downloads
StarBBS Terminal Service
StarBBS is a Bulletin Board System with message forums, private messaging, mail, and chatroom on Terminal and Web service. Please visit: (only in Traditional Chinese) http://starbbs.net/~bbs/ or: telnet://starbbs.net1 weekly downloads


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Watch the "second-10th" TR BBQ live in 360 degrees right now
This year's TR BBQ is up and running. We'll be streaming it all day from our Theta S 360 degree camera so you can...
Type: News story Tags: Miscellaneous The Tech Report
Opera set to sell core units to Chinese business for $600 million
Opera Software, best known for its desktop and mobile browser, may soon become Chinese instead of Norwegian. The company is inking a $600...
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Razer brings its mechanical keyboard expertise to the iPad Pro
The iPad Pro may not be the gaming PC of the future just yet, but Razer isn't waiting for the platform to churn out desktop...
Type: News story Tags: Input devices Mobile computing
Nvidia VR Funhouse launches alongside new GeForce drivers
Nvidia's latest Game Ready drivers are out this morning, and version 368.81 is all about VR. This update is optimized for Raw Data,...
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AMD and Firaxis join forces to bring DX12 goodies to Civilization VI
The Civilization family of games is without a doubt one of the most popular and long-running franchises out there for the PC. Developer Firaxis has...
Type: News story Tags: Graphics Gaming Software
Cooler Master MasterBox 5 makes modularity more attainable
Cooler Master's MasterCase 5 is a favorite of ours for higher-end systems, but its $105-and-up price tag is rather spendy for budget builds. Cooler...
Type: News story Tags: Cases
Razer Abyssus V2 mouse gives gamers the essentials for $50
Razer is making its dizzying range of gaming mice more accessible today. The Abyssus V2 offers a 5000-DPI optical sensor, three-color backlighting (in dark...
Type: News story Tags: Input devices
Doom's long-awaited Vulkan support is rolling out today
Doom's Vulkan implementation made waves at the GeForce GTX 1080 launch. Developer id Software showed the Vulkan version of the game running with...
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Radeon Software 16.7.1 lands with power fixes for RX 480
There's been no small amount of talk in the past week or so surrounding the PCIe slot power draw from AMD's new Radeon...
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Nvidia's VR Funhouse and Ansel game photo tool will arrive soon
When Nvidia announced the GTX 1080 at Dreamhack back in May, the announcement overshadowed the fact that the company also teased a few upcoming...
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Microsoft's final Windows 10 upgrade prompt goes full-screen
The free upgrade offer for Windows 10 ends July 29, and Microsoft wants to make sure that all users that haven't yet upgraded are aware...
Type: News story Tags: Software Operating systems Windows
GeForce Experience 3.0 beta puts games front and center
Nvidia's GeForce Experience is probably a utility familiar to many a PC gamer by now. At least on my Nvidia-equipped PCs, the software helpfully...
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Thermaltake Core P3 case takes up less wall space
Earlier this year at Computex, we took a peek at Thermaltake's Core P3, a wall-mounted case that puts the hardware inside on full display....
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The next Android release will be called Nougat
Back at its I/O conference, Google called for the Android community to submit names for its upcoming Android N release. Android has traditionally been named...
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Dell shows off whiteboard-sized 70" interactive display
It seems that manufacturers may have found themselves a new market to explore: business- and classrooms. Not to be outdone by Microsoft's Surface Hub,...
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Corsair's K70 RGB Rapidfire gaming keyboard reviewed
Corsair's K70 RGB Rapidfire is the first keyboard on the market with Cherry's MX Speed switches, a new clicker that offers shorter travel and a...
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Only one month to go before the "second-10th" TR BBQ
Family and friends can attest to the fact that I caught "BBQ brain" early this year. There's just something about a ten-year anniversary that feels...
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3DMark is getting a full-featured DirectX 12 benchmark
Preeminent benchmarking tool 3DMark is getting a new game-like benchmark to test DirectX 12 performance soon, according to the Futuremark blog. The new test,...
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|Crucial fills out MX300 SSDs with 275GB, 525GB, and 1TB models
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|Pascal powers up pro graphics with Nvidia's new Quadros
|Phanteks breaks into custom liquid cooling with its Glacier G1080
|Adata covers all of its bases with fast, durable external SSDs
|MSI's Radeon RX 480 Gaming family will arrive in mid-August
|Man, you make it sound like I'm the Pope or something. We do this work partially because graphics cards are complex products that need deep analysis,...