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Sometimes the best view of a city is from the water! From Parisian dinners to German castles, these are our picks for Europe's top sightseeing river cruises
Things To Do
The best cities to visit in Switzerland can easily be reached with a Swiss Pass that covers trains, lake steamers and postal buses, while also providing access to over 470 museums
Travel from Paris to Nimes on a high-speed TGV. The Arena of Nimes stands proud & welcoming, you'll feel like you just arrived in Rome. From architecture to gardens & museums, Nimes has it all!
Visit the Loire Valley by train & experience one of France's most popular regions. With chateaux & breathtaking views, a trip to the Loire Valley leaves lasting memories in the minds of all who visit.
Travel by train from London to Paris on Eurostar with Rail Europe. Get info on classes of service & amenities for Eurostar and find things to do during your visit in London & Paris.
Travel France by train with Rail Europe and discover some hidden gems, 'off the beaten track' destinations that we think deserve some space on travelers' itineraries.
Travel Slovenia by train and experience a vacation like no other! Offering activities for all, it's easy to see why so many fall in love with Slovenia each year!
Check out these Chunnel facts to help you realize that while not an official wonder of the world, the Chunnel is a wonder under the world. One best experienced by train!
Take the train from Helsinki to Rovaniemi & visit Santa Claus! Learn about Rovaniemi, a city full of wonder, magic & Christmas Spirit, found just above the Arctic Circle.
Travel by train to experience the magic of the German Christmas markets filled with gifts, toys, ornaments, gingerbread & other tasty treats.
Travel on the Bosfor Express from Bucharest to Istanbul to experience a city like no other. Istanbul is seated on two continents & offers something for every traveler!
Travel by train from London to Liverpool to get a dose of The Beatles & more. With its UNESCO worthy waterfront, museums & stellar 'football' team, Liverpool has something for all.
Visit the Red Star Line Museum in Antwerp. Follow personal stories from some of the 2 million immigrants who left Antwerp for New York – or even trace your own family history!
Learn more about some of our favorite haunted castles in Europe. From England to Romania, here's our list of some of the most sought-after haunted castles for ghostly encounters. Enjoy!
Travel the Paris Metro with us as we explore the steampunk Art et Metiers station. Get info on how to reach this station on your next trip to Paris.


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For our third annual list, we sought to highlight literature that exposes readers to cultures and ways of life that may be different from their own...
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All Product Details
A Valentine's Day dance at Greg's middle school has turned his world upside down. As Greg scrambles to find a date, he's worried he'll be left out in the cold on the big night. His best friend, Rowley, doesn't have any prospects either, but that's a small consolation.
An unexpected twist gives Greg a partner for the dance and leaves Rowley the odd man out. But a lot can happen in one night, and in the end, you never know who's going to be lucky in love.
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subset: commoncrawl


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I'm new to Obj-C and I have run in to a very, very basic mental block that's making me feel a little stupid. I want to pass a variable from one method to another in an purely objective-C way. So far I'm stuck and have resorted to writing it in C. In C it goes as follows;
//detect the change in the segmented switch so we can; change text
- (IBAction)switchChanged:(id)sender
NSLog(@"Switch change detected");
//grab the info from the sender
UISegmentedControl *selector = sender;
//grab the selected segment info from selector. This returns a 0 or a 1.
int selectorIndex = [selector selectedSegmentIndex];
changeText (selectorIndex);
int changeText (int selectorPosition)
NSLog(@"changeText received a value. Selector position is %d", selectorPosition);
//Idea is to receive a value from the segmented controler and change the screen text accordingly
return 0;
This works perfectly well, but I want to learn how to do this with objects and messages. How would I rewrite these two methods to do this?


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Earlier this week, Pirelli World Challenge competitiors RealTime Racing announced a testing program for the new Acura NSX GT3, which was unveiled to the public at the New York International Auto Show in April. Veteran Dutch sports car racer Peter Kox has been retained to serve as a test driver …Read More »
NASCAR to Implement Chassis Reinforcement at Restrictor Plate Tracks
In a teleconference Thursday morning, Gene Stefanyshyn, NASCAR senior vice president of innovation and racing development, announced that teams in the NASCAR Sprint Cup and XFINITY series will need to strengthen the chassis in 2017 at Daytona International Speedway and Talladega Superspeedway. Starting with the beginning of Speedweeks next year, …Read More »
Michael Lira, Spencer Boyd Plan XFINITY Series Debuts
This weekend will mark a new era for two up-and-coming drivers, trying to make it to NASCAR's elite level, the Sprint Cup Series. Michael Lira and Spencer Boyd will both make their XFINITY Series debut during Saturday night's U.S. Cellular 250 at Iowa Speedway. Lira, 18, has competed part-time in the …Read More »
NASCAR Sprint Cup Series to Use 2017 Rules at Michigan
During a teleconference on Thursday morning, NASCAR officials announced that the Sprint Cup Series will use the provisional 2017 rules package at Michigan for the Pure Michigan 400 on Aug. 28. It will be the third race this year to use the package, along with June's FireKeepers Casino 400 at …Read More »
Did You Notice? … Jeff Gordon's Return Reveals NASCAR's Need for Star Power
Did You Notice? … The television audience for Sunday's Brickyard 400 increased despite one of the least competitive races in the track's stock car history? NASCAR pulled a 3.1 Nielsen rating, up 3 percent, while viewership increased 11 percent to 5.21 million. That came despite a record-low four lead changes, …Read More »
2-Headed Monster: Who's the Title Favorite: Kyle Busch or Brad Keselowski?
Seven past champions are racing full-time in the 2016 NASCAR Sprint Cup Series, and from the looks of it, one of them will take the title when the checkered flag falls at Homestead in November. Cup champs Brad Keselowski, Kevin Harvick, Tony Stewart, Kyle Busch, Matt Kenseth, Kurt Busch and …Read More »
Happiness Is…Games
What is to be made of Cup racing at the moment? From a distanced perspective, it is a wild hodge-podge of things, full of positives that run along with various questions. The aero package introduced this year has looked to be a wonderful improvement over the past couple years, though …Read More »
Eyes on XFINITY: Get Ready to Race with Stewart-Haas
Stewart-Haas Racing has experienced a tremendous amount of growth in its relatively short existence. In 2017, the organization will expand once again, this time to the XFINITY Series. News broke on Monday that the team would field a single-car entry in NASCAR's second-tier division next season with driver and sponsorship …Read More »
Nitro Shots: Signs of Growth
Over the last few years in motorsports, when someone lost a sponsor, it may or may not have been said outright, but you knew a team was on deathwatch. It didn't matter how many times they put out announcements saying they were looking for new partners and were optimistic they'd …Read More »
Truckin' Thursdays: Gearing Up for the Inaugural Chase for the Championship
When the Camping World Truck Series heads to Pocono Raceway Saturday afternoon, it will knock off one of the five remaining races to set the inaugural Chase field. Only five drivers have punched their tickets with a victory, so there's still quite a bit of uncertainty in exactly who will …Read More »


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Sufferers frequently experience irritated, watery eyes and runny noses. Histamines attach to blood vessel receptors causing them to enlarge. Natural nasal sprays - Extremely effective natural nasal sprays that are doctor recommended for example Sinu - Soothe, Sinus Buster and Sinol can be used instead of non-prescription nasal sprays. Nasal sprays containing saline solution including Sterimar can relieve sinus congestion, remove allergens inside the nasal passages and improve sinus drainage. Both acupuncture and hypnosis may work by reinforcing the persistence for giving up smoking.
Acute Sinusitis is surely an inflamation of the sinuses and sinus cavities, usually due to bacteria. Everyone that has allergies experiences different symptoms congestion, runny nose, sneezing, sniffling, coughing, red, itchy eyes, and swelling. Other herbs which might be beneficial for diabetes include bilberry, buchu, dandelion root, and goldenseal and uva ursi. Which of most the words was your mind most drawn to, in other words, which from the words are a lot of people most familiar with. Allergy Treatment Sinol Allergy treatment uses Capsaicin, a component that comes in the pepper plant and is found in most spicy foods.
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Panasonic DMR-BS850 Freesat Blu-ray recorder
They've had Blu-ray recorders in Japan for donkey's years, but the lack of free HD content in the UK has delayed their introduction here. But the emergence of Freesat - now a year old - has finally made Blu-ray recording a reality for us Brits, and naturally Panasonic is the company to make it happen given its previous pioneering exploits in the Blu-ray and Freesat markets.
The company has launched two Blu-ray/hard-disk combis - the top-end 500GB DMR-BS850 on test here and the 250GB DMR-BS750 - as well as a Freesat-equipped DVD/HDD model. At £1000 the BS850 isn't cheap, but when you take a look at the vast array of features - many of which you won't find anywhere else - it's easy to see where your money is going.
The DMR-BS850 is the first hard-disk combi recorder to feature twin tuners, making it possible to record one channel while watching another, or record two channels while watching a previous recording. If you watch as much TV as we do, this will be music to your ears, and the presence of features like series recording makes it even more convenient to watch and record the programmes you love.
Because it's equipped with Freesat tuners, you can receive high-definition programmes from BBC HD and ITV HD for free and record them directly onto the hard-disk. To do this, the unit uses a "DR" recording mode, which captures the raw bitstream (as well as subtitles and audio descriptions) rather than decoding it first. That means recorded pictures look identical to the live broadcast and subsequently allow you to make a pristine digital copy on Blu-ray.
That said, you can't just make HD copies willy nilly. Broadcasters have the ability to flag high-def broadcasts and limit the number of copies that can be made. At present the BBC is flagging its programmes as "Copy Once" while ITV HDs are "Copy Never" although it's by no means set in stone - there's talk of BBC HD allowing unlimited copies later this year and ITV HD could have a change of heart. Until then, these restrictions could be a real turn off for people who like to share their favourite shows with family and friends.
When making a Blu-ray copy, the unit's MPEG4 H.264 encoder can compress the file at a lower bitrate but retain its high-def resolution, which takes up less space on the disc without massively compromising on picture quality.
Although high-def recording is the BS850's raison d'être, there are many more strings to its bow. It's also a high-spec Profile 2.0 Blu-ray player, equipped with Panasonic's lauded P4HD and PHL Reference Chroma Processor Plus technology, and it supports a healthy range of multimedia formats, including DivX, MP3, JPEG, AVCHD and SD Video. All of these, except DivX, can be copied to the hard-disk from USB or SD card (but not vice-versa), turning the BS850 into a multimedia hub, and it can even rip CDs and tag them automatically using the pre-installed Gracenote database.
Rear panel connections include HDMI, Component, S-Video and Composite video outputs, Scart input and output, two digital audio outputs and analogue stereo output. The Ethernet connection on the back not only allows you to download BD-Live movie extras but also lets you browse videos on YouTube or photos on Google Picasa through the Viera Cast feature. The Ethernet port will also provide access to the BBC iPlayer when it becomes available on Freesat later this year.
The BS850 isn't a bad-looking machine around the front, with slim dimensions, a dark mirrored fascia and legible display panel. On the front you'll find a USB port and SD card slot, a DV input for camcorder dubbing, plus S-Video, Composite and stereo audio inputs, reflecting the designs seen in Panasonic's DVD recorders in the past.
In action the BS850 is wonderfully intuitive, despite its potentially confusing array of functions. Channel tuning is quick and painless, while the onscreen displays like the EPG, Direct Navigator menu (where you find your recordings) and editing screens are straightforward. To cap it all, the button arrangement on the remote is superb.
High-def recordings from BBC HD look impeccable, with the BS850 retaining every last scrap of detail in the original broadcast. Programmes like Bleak House and Reggie Perrin are reproduced with mesmerising depth and clarity, while vivid colours blaze from the screen. HD recordings compressed to HL (the lowest-bitrate high-def recording mode) look sharp and natural, with fewer artefacts than we expected.
And its performance with pre-recorded Blu-ray discs is every bit as impressive as the DMP-BD60 and BD80, offering sharp and clean 1080/24p pictures that clearly benefit from P4HD's awesome processing power. Even upscaled DVDs look incredible, with natural colour reproduction, remarkable detail retrieval and no edge artefacts to speak of.
The lack of multichannel analogue outputs on the back means you'll need an AV receiver with HDMI inputs to enjoy Dolby True HD and DTS HD Master Audio tracks from Blu-ray. If you've got one, you're in for a treat – the sound on offer is sharp, dynamic and fulsome. CD and MP3 playback are also hugely enjoyable.
The level of technological innovation offered by the DMR-BS850 made it the most eagerly anticipated product of the year, and thankfully it doesn't disappoint. The combination of twin Freesat tuners, Blu-ray recording, a huge hard-disk, wide multimedia support and sensational Blu-ray playback make it an irresistible proposition. Yes it's expensive but new technology always is - if you have the cash and don't fancy lining Murdoch's pockets then it's definitely worth every penny.
Our only grievances are the paucity of HD content on Freesat and the off-putting copy restrictions placed on high-def content, but both are out of Panasonic's control and will no doubt be rectified in the near future.
Best Comic-Con 2016 trailers: Justice League, Wonder Woman, and more
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Pokemon Go the Movie planned, live-action film rights snapped up
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- Pokemon Go the Movie planned, live-action film rights snapped up
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Highest Rated Titles With Katherine Jackson
- Job Types
- Movies or TV
- Genres
- Keywords
- IMDb Rating
- Instant Watch Options
- In Theaters
- On TV
- Release Year
1. Michael Jackson Memorial (2009 TV Movie)
180 min | Documentary, Music
A live telecast of the public memorial service for the king of pop, Michael Jackson.
Directors: Gregg Gelfand, Kenny Ortega | Stars: Michael Jackson, Elizabeth Berkley, Kobe Bryant, Mariah Carey
Votes: 350
2. Michael Jackson: The Immortal World Tour (2012 TV Movie)
87 min | Documentary
Director: Adrian Wills | Stars: Kevin Antunes, John Branca, Mitchell Head, Jackson 5
Votes: 57
3. The Michael Jackson Interview: The Footage You Were Never Meant to See (2003 TV Movie)
This new unedited footage tapped by Michael Jackson's team in Neverland, offers a true representation of the controversial TV special "Living with Michael Jackson" of Martin Bashir, very far from the twisted initial broadcast.
Stars: Martin Bashir, Ian Drew, Karen Faye, Jermaine Jackson
Votes: 257
4. Ebony/Jet Showcase (1982– )
30 min | Talk-Show
Magazine show based on the two African-American magazines "Ebony" and "Jet".
Stars: Debra Crable, Darryl Dennard, Elliott Francis, Greg Gumbel
Votes: 14
5. Michael Jackson's Journey from Motown to Off the Wall (2016)
93 min | Documentary, Music
A look at the life of the late pop star Michael Jackson from his early days at Motown Records to the release of his hit 1979 album, Off the Wall.
Director: Spike Lee | Stars: Michael Jackson, Jackson 5, Berry Gordy, Suzanne De Passe
Votes: 1,020
6. This Is It (2009)
PG | 111 min | Documentary, Music
A compilation of interviews, rehearsals and backstage footage of Michael Jackson as he prepared for his series of sold-out shows in London.
Director: Kenny Ortega | Stars: Michael Jackson, Alex Al, Alexandra Apjarova, Nick Bass
Votes: 33,116 | Gross: $71.84M
7. Michael Jackson: The Life of an Icon (2011)
149 min | Documentary, Music
Featuring never before seen footage and exclusive interviews with Michael's Mother Katherine and siblings Tito and Rebbie Jackson covering all the highs and also the lows in the King of ... See full summary »
Director: Andrew Eastel | Stars: David Gest, Katherine Jackson, Tito Jackson, Rebbie Jackson
Votes: 653
8. The Michael Jackson Story (2003 TV Movie)
95 min | Documentary, Music
This is about the story about the king of pop and his brothers parents kids and life
Director: Steve Cole | Stars: Seb Fontaine, Michael Jackson, Katherine Jackson, Jermaine Jackson
Votes: 26
9. Cutting Edge (1990– )
Weekly documentary series focussing on political and social issues.
Stars: Steven Mackintosh, Jim Carter, Paul Thornley, Paul Gascoigne
Votes: 72
The X Factor (2011–2013)
Live Performance Show #6
Music, Reality-TV
Director: Jonathan Bullen | Stars: Steve Jones, Paula Abdul, Simon Cowell, L.A. Reid
Votes: 14
11. Michael Jackson: The Inside Story - What Killed the King of Pop? (2010 TV Movie)
70 min | Documentary
This hard-hitting documentary traces the last months of the singer's life, examines the circumstances that led to his untimely passing, and explores the controversy and unanswered questions... See full summary »
Director: Sonia Anderson | Stars: Susan Etok, Uri Geller, M.D. Gregory Alan Smith, Janet Jackson
Votes: 46
12. The Jackson Family Honors (1994 TV Special)
120 min | Documentary, Family, Music
Stars: Boys II Men, Cindera Che, Céline Dion, Aretha Franklin
Votes: 42
13. Larry King Live (1985– )
60 min | News, Talk-Show
Popular and controversial journalist Larry King hosts this CNN call-in talk show.
Stars: Larry King, Bill Maher, Bob Woodward, Ryan Seacrest
Votes: 808
14. The Jacksons: A Family Dynasty (2009– )
Music, Reality-TV
Chronicles the personal and professional lives of Jackie, Jermaine, Tito and Marlon Jackson as they prepare for The Jackson Five reunion, while also coming to terms with Michael's death.
Stars: Jackie Jackson, Jermaine Jackson, Marlon Jackson, Tito Jackson
Votes: 123
15. Armed & Famous (2007– )
Stars: Erik Estrada, Trish Stratus, Jason 'Wee Man' Acuña, La Toya Jackson
Votes: 169
16. The X Factor (2011–2013)
Music, Reality-TV
In this American version of the hit UK show, Simon Cowell and his fellow judges search for a singer who has the "X factor".
Stars: Simon Cowell, Demi Lovato, L.A. Reid, Mario Lopez
Votes: 5,271
17. The Oprah Winfrey Show (1986–2011)
60 min | Talk-Show
Chicago-based daytime talk-show host Oprah Winfrey invites a guest panel to discuss a topic, in front of a studio audience. The topics are often controversial or sensational.
Stars: Oprah Winfrey, Nate Berkus, Gayle King, Chris Rock
Votes: 3,792
18. MTV Icon: Janet Jackson (2001 TV Special)
120 min | Documentary, Music
MTV's inaugural "ICON" event pays tribute to Janet Jackson, in a production that's 90% tribute, 10% celebrity roast. The timeline of Janet's career is explored through widescreen ... See full summary »
Director: David Mallet | Stars: Janet Jackson, Jimmy Jam, Katherine Jackson, Sean Combs
Votes: 204
19. Access Hollywood (1996– )
30 min | News
Celebrity information, hollywood gossip, and other news from the world of entertainment.
Stars: Billy Bush, Nancy O'Dell, Giselle Fernandez, Pat O'Brien
Votes: 343
20. Piers Morgan Tonight (2011– )
60 min | Talk-Show
Stars: Piers Morgan, Newt Gingrich, Rudy Giuliani, Gloria Allred
Votes: 443
21. This Is David Gest (2007– )
Stars: Mackenzie Crook, David Gest, Marty Benson, Jason Donovan
The Oprah Winfrey Show (1986–2011)
All New! A World Exclusive: Oprah Talks to Michael Jackson's Mother, Katherine, and Visits with His Children
Stars: Oprah Winfrey, Yashi Brown, Donte Jackson, Genevieve Jackson
Piers Morgan Tonight (2011– )
Episode dated 14 May 2012
Stars: Katherine Jackson, Piers Morgan
Access Hollywood (1996– )
Episode dated 21 October 2009
Stars: Larry Mendte, Giselle Fernandez, Pat O'Brien, Nancy O'Dell
Ebony/Jet Showcase (1982– )
Episode dated 6 November 1987
Stars: Debra Crable, Darryl Dennard, Katherine Jackson, Loose Ends
Armed & Famous (2007– )
If He Starts Pointing the Gun? Do What You Were Trained to Do.
Stars: Jason 'Wee Man' Acuña, Erik Estrada, La Toya Jackson, Trish Stratus
This Is David Gest (2007– )
It's My Party and I'll Cry If I Want To...
Director: Craig Blackhurst | Stars: Mackenzie Crook, Pamela Bach-Hasselhoff, Richard Benjamin, Marty Benson
Larry King Live (1985– )
Michael's Mother
News, Talk-Show
Star: Katherine Jackson
Cutting Edge (1990– )
The Jacksons Are Coming
A documentary following members of the Jackson Five as they search for a new home in the Devon fishing village of Appledore.
Director: Jane Preston | Stars: Jackie Jackson, Katherine Jackson, Michael Jackson, Tito Jackson


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Top Definition
When you pretend to teabag a girl and then shit in their mouth instead.
I just Sibonered you, BITCH.
what a fag!
what a fag!
di Dick Fitsnuggly 25 ottobre 2007
Trending Now
Expressing the act of an erection in a German Like Accent
"Look at SiBoner on that guy!"
di Anonymous 22 ottobre 2003


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- Golden Corral coming to Cape; may hire 100 workers (7/21/16)8
- Arrest warrants filed for six drug suspects in Cape (7/19/16)6
- Area groups working together to reintroduce elk in Missouri (7/18/16)1
- Suspect in downtown Cape shooting ID'd in court (7/20/16)2
- Prosecutor says shooting by state trooper was justified (7/24/16)14
- Pincksten's newest renovation project: 328 S. Spanish St. (7/17/16)6
- Trooper-involved homicide case rests in prosecutor's hands (7/17/16)15
- Hastings in Cape closing (7/22/16)5
- Jackson's former police dog euthanized Monday (7/21/16)1
- 'I want to see how far I can go' (7/21/16)2
Fiery crash on Wisconsin road kills at least 10
CEDAR GROVE, Wis. -- More than two dozen vehicles crashed on a foggy highway Friday morning, killing 10 people in a pile of charred and twisted metal in the deadliest auto accident in state history. At least 34 others were injured, several critically.
Rescue workers picked through the wreckage for more victims in four smoldering piles along Interstate 43 some 60 miles north of Milwaukee.
"I would just say, that in my 21 years, it's the most horrific scene I have ever seen," Sheboygan County Sheriff Loni Koenig said.
The previous record for fatalities in a Wisconsin traffic accident was nine on May 30, 1937, Wisconsin State Patrol Lt. Nick Scorcio said.
Some victims were burned beyond recognition and authorities said it may take DNA analysis for identities.
"I can't even describe how awful that scene is out there," Koenig said.
She said seven people were in critical condition at area hospitals.
The crashes happened about 7:30 a.m. on both sides of the interstate as heavy fog engulfed the road just west of Lake Michigan. One vehicle after another plowed into each other, and at least eight burst into flames. State Patrol Sgt. John Jones said visibility was "next to nothing" when the first officers arrived.
He said many of the cars may have crashed north of the main collision by driving through the fog at a high rate of speed.
"We have vehicles that have been double stacked -- vehicles on top of vehicles, vehicles underneath the tractor-trailer unit," Jones said. "I tried to walk around there and get an accurate count of the vehicles, but we couldn't."


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New York, NY It is an exciting time to be at TouchTunes, we are developing new revenue streams, creating new products and expanding into Europe. The Mobile team has just released the next generation of the TouchTunes App on Android and iOS. TouchTunes has very6/7/2016 New York, NY Save This Job
Momo?s Product Manager shoulders the responsibility of leading a team of engineers, data scientists, and designers to achieve the company?s vision for reinventing people?s social behaviors. We are looking for an entrepreneurial, analytical, and passionate Product Manager to help5/31/2016 San Francisco, CA Save This Job
Job Description: Position Reports to CEO ?Lead a team of outstanding service professionals in the healthcare automation space to drive hospital customers to highest level of financial and operational performance. ?Drive customer satisfaction scores and value seen by customer in6/27/2016 Pittsburgh, PA Saved Job
You'll lead the design and development of our eCommerce experience. Together with our UX designer and lead developer, you will define what our website looks like (the most critical touchpoint of our business).7/27/2016 Los Angeles, CA Save This Job
We are looking for a Director of Product to join our rapidly growing team and develop next-generation mobile social gaming experiences for our users. The position title and level can be tailored to your experience and skill sets. Â ResponsibilitiesManage multiple project teamsSan Francisco, CA Save This Job
at Houzz Palo Alto, CA Houzz, the revolutionary platform for residential remodeling and design, is looking for a consumer marketing expert to help increase traffic, drive new user acquisition, revenue and long term engagement. Responsibilities Create and execute paid search6/19/2016 Palo Alto, CA Save This Job
New York City, NY It?s the age of the consumer, and the content that consumers create and share is driving brand perception, product discovery, and purchase decisions. Offerpop is a marketing platform that enables B2C marketers to generate, curate and leverage on-brand5/31/2016 New York, NY Save This Job
We have a unique opportunity for a Senior Director to lead our Media strategy, planning and buying capability at Gree. Our internal UA, BI and creative teams are already known for pioneering work across mobile media formats, analytics, and franchise excellence. Â Currently weSan Francisco, CA Save This Job
Glooko seeks a driven and enthusiastic team player to join our team as Director of Health Plan Sales, responsible driving sales of Glooko?s diabetes platform to health plans (e.g., commercial payers). He/she will have experience selling mobile health, chronic disease6/13/2016 Palo Alto, CA Save This Job
DescriptionWe are looking for a Director/Sr. Director of Marketing Strategy & New Opportunities to help GREE become the most player centric gaming company in the world. If you are someone who can see the potential in games before they even start, gets fired up to channel userSan Francisco, CA Save This Job
NEW YORK, NYPRODUCT FULL-TIME Hi! Thanks for checking us out. It?s a pleasure to meet you... Offerpop's Visual UGC Marketing SaaS platform empowers brands to encourage and leverage user generated content at every stage of the buyer journey, improving marketing performance.5/31/2016 New York, NY Save This Job
at Houzz Palo Alto, CA Houzz, the revolutionary platform for residential remodeling and design, is looking for an email marketing expert to drive direct marketing initiatives that engage, retain and convert our users. This role will ensure ongoing campaigns including our6/19/2016 Palo Alto, CA Save This Job
Job ID 2015-1248 Job Locations US-NY-New York Category National Advertiser Sales More information about this job: Overview: We are looking for a talented Senior Director - Ad Partnerships to join the Cardlytics Advertiser Sales team. Ideal candidates will display the ability4/16/2016 New York, NY Save This Job
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text:
"In this book, Joe Nowinski once again proves his ability to integrate the science and experience of Alcoholics Anonymous and to explain both in clear, unpretentious language."
--Keith Humphreys, Professor of Psychiatry, Stanford University
"Nowinski has done a great service by summarizing, synthesizing, and skillfully interpreting many of the landmark studies that demonstrate not only that AA and Twelve Step treatments are still relevant in twenty-first-century addiction health care, they are among the most effective interventions currently available."
--John F. Kelly, PhD, Elizabeth R. Spallin Associate Professor of Psychiatry in Addiction Medicine, Harvard Medical School
"Joe makes the design and findings from complex research studies understandable to the lay reader, without dumbing it down, and with just the right amount of detail. The book thus represents a valuable new resource for anyone interested in a comprehensive summary of what we know about AA in terms of its effectiveness."
--Lee Kaskutas, Senior Scientist, Alcohol Research Group, Public Health Institute
"This is straight talk about how and why the Twelve Steps help addicts stay sober in an increasingly substance-abusing world."
--Anna Jedrziewski, Retailing Insight


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The World will never be at peace as long as we allow British and French bankers to Rob and Manipulate the world!
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"And he cried mightily with a strong voice, saying, Babylon the great is fallen, is fallen, and is become the habitation of devils, and the hold of every foul spirit, and a cage of every unclean and hateful bird."Revelation 18:2
He also called Babylon A Group of many nations and tongues... the USA is not a group of many nations and tongues... we speak one language well recently 2 languages with mexico.
Mystery Babylon is Europe and the whore of babylon that reigneth over kings is the queen of England
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Deutsche Bank's net income plummets
Sanders Supporters Walk Out Of Democratic Convention
Black Protesters at DNC SHOUTS: "Don't Vote For Hillary, She's Killing Black People"
Hillary Clinton will nominate justices to the Supreme Court who are prepared to overturn Citizens United."
Day After Clinton Cash Film's Go Worldwide, CEO Forced To Step Down
Ancient 'toilet paper' proves that Silk Road travelers spread parasites as they traveled
Sheriff David Clarke Says the DNC 'Seems to Be About Embracing Criminality'
Why News Junkies Are So Glum About Politics, Economics, and Everything Else
Here's What Happened When Democrats Recited 'The Pledge Of Allegiance' At The DNC
Superhuman Tech? Most Fear Worst..
Wikileaks Proves Primary Was Rigged: DNC Undermined Democracy
WIKILEAKS JULIAN ASSANGE Says He Has NEW Emails That Should Indict Hillary…And Why He's A Trump Fan
Undercover Video: Hillary Clinton Delegate Explains Her Deceptive Propaganda to Ban Guns
Is State Dept. Is Protecting Hillary Rotten Clinton's Presidential Bid?
Robots, drones fill police ranks
Companies around globe packing earth orbit with satellites to meet communications demands
Rise of black nationalist groups
Report: Mr. Robot's one-time only VR experience will return next week
'Kill More Cops' Graffiti Mural Appears on Freeway
DNC erects four-mile eight-foot tall fence around Philly convention site
Should the Postal Service Handle Your Loans as Well as Your Mail? Elizabeth Warren Thinks So.
HERE IT IS=> Detailed List of Findings in Wikileaks DNC Document Dump
BREAKING: That Was Fast! Hillary Immediately Brings Disgraced DNC Chair Onto Her Campaign! Do you think that Hillary has something to hide?
According to Soros, there's about to be an all-out class war riots, police state and civil war for America
Torrential Downpour To Kick Off Hillary's #DNC Election Steal
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Mattice Made it Up
The 24-year-old Johnstown woman who said she was abducted has been charged by State Police with reporting a false abduction.
The 24-year-old Johnstown woman who said she was abducted has been charged by State Police with reporting a false abduction.
This Central New York deli made Matt's day. Today he got to eat the 42nd Street Reuben from Pumpernickel Deli.
The Stevens Swan Humane Society has a record number of pets waiting to be adopted.
The New York Governor has signed a new law into effect named after Actor Peter Falk. Falk attended Hamilton College and Syracuse Universty.
There are many things about our region that are not widely known, even to those who live here.
We've got more adorable animal cuteness for you to enjoy courtesy of Syracuse.com and The Wild Animal Park in Chittenango. Oh my goodness, it's baby snow leopards.
We have enough to worry about everyday, but if you live in Rome, New York you have one more thing to add to that list - A scammer in the area.
It wasn't that long ago that the City of Utica made a deal with Visions to purchase the historic Hotel Utica. Now, another major hotel in downtown Utica is on the market.
There will be new burger options coming to New Hartford. Sangertown Square just announced that Kraze Burgers will open this fall in Center Court.
Did Ed Sheeran secretly marry his girlfriend in a private ceremony? The Internet seems to think so!
Wild Animal Park in Chittenango is holding a very special event called "Walk on the Wildside." Proceeds for the event benefit Make-A-Wish of Central New York.
Who's up for a little fun? Well, we've got you covered - A wonderful night out is happening at Valentino's Banquet Hall in New Hartford.
Are you familiar with the latest way to navigate across a lake or pond this summer? The newest craze is stand up paddle boarding, and Lite 98-7 has your chance to win one.
'😑,' Nick wrote.
Summertime means vacations, county fairs, theme parks, parades and more crowded events than you can shake a stick at. Here's a couple of simple tips to keep your children safe when in large crowds.


text:
I have an application that has only needed to connect to a SQL Server DB thru ODBC to call a function. Now it needs to call the same function with an Oracle back-end.
This is the code for SQL Server and it works perfectly:
public function generateMasterKey($project_name, $table_name) {
$master_key = odbc_result($this->odbc->Prepare("DECLARE @as_master_key varchar(26) EXEC [dbo].[GET_UNIQUE_MASTER_KEY] @as_project_name = N'$project_name', @as_database_site = N'CMPL', @as_user_initials = N'SK', @as_table = N'".$table_name."', @as_master_key = @as_master_key OUTPUT SELECT @as_master_key as N'master_key'"), 'master_key');
return $master_key;
Now I just need the syntax for an Oracle DB.
I am new to Oracle - so any help would be very much appreciated.


text:
Effectiveness of smoking cessation therapies: a systematic review and meta-analysis
Smoking remains the leading preventable cause of premature deaths. Several pharmacological interventions now exist to aid smokers in cessation. These include Nicotine Replacement Therapy [NRT], bupropion, and varenicline. We aimed to assess their relative efficacy in smoking cessation by conducting a systematic review and meta-analysis.
We searched 10 electronic medical databases (inception to Sept. 2006) and bibliographies of published reviews. We selected randomized controlled trials [RCTs] evaluating interventions for smoking cessation at 1 year, through chemical confirmation. Our primary endpoint was smoking cessation at 1 year. Secondary endpoints included short-term smoking cessation (~3 months) and adverse events. We conducted random-effects meta-analysis and meta-regression. We compared treatment effects across interventions using head-to-head trials and when these did not exist, we calculated indirect comparisons.
We identified 70 trials of NRT versus control at 1 year, Odds Ratio [OR] 1.71, 95% Confidence Interval [CI], 1.55–1.88, P =< 0.0001). This was consistent when examining all placebo-controlled trials (49 RCTs, OR 1.78, 95% CI, 1.60–1.99), NRT gum (OR 1.60, 95% CI, 1.37–1.86) or patch (OR 1.63, 95% CI, 1.41–1.89). NRT also reduced smoking at 3 months (OR 1.98, 95% CI, 1.77–2.21). Bupropion trials were superior to controls at 1 year (12 RCTs, OR1.56, 95% CI, 1.10–2.21, P = 0.01) and at 3 months (OR 2.13, 95% CI, 1.72–2.64). Two RCTs evaluated the superiority of bupropion versus NRT at 1 year (OR 1.14, 95% CI, 0.20–6.42).
Varenicline was superior to placebo at 1 year (4 RCTs, OR 2.96, 95% CI, 2.12–4.12, P =< 0.0001) and also at approximately 3 months (OR 3.75, 95% CI, 2.65–5.30). Three RCTs evaluated the effectiveness of varenicline versus bupropion at 1 year (OR 1.58, 95% CI, 1.22–2.05) and at approximately 3 months (OR 1.61, 95% CI, 1.16–2.21). Using indirect comparisons, varenicline was superior to NRT when compared to placebo controls (OR 1.66, 95% CI 1.17–2.36, P = 0.004) or to all controls at 1 year (OR 1.73, 95% CI 1.22–2.45, P = 0.001). This was also the case for 3-month data. Adverse events were not systematically different across studies.
NRT, bupropion and varenicline all provide therapeutic effects in assisting with smoking cessation. Direct and indirect comparisons identify a hierarchy of effectiveness.
Smoking is the leading cause of preventable death in the world
Drug therapy has been increasingly relied upon to assist in smoking cessation. The most common of these has been nicotine replacement therapy [NRT]
How effective are pharmacologic smoking cessation therapies? No systematic review and meta-analysis has examined this issue since the availability of information of the newest agent. We conducted a meta-analysis of Randomized Controlled Trials [RCTs] to identify the effectiveness of the various pharmacological interventions in improving cessation rates.
Eligibility criteria
Our primary outcome of interest was smoking cessation at 1 year. Our secondary outcomes were short-term smoking cessation defined as 3 months after initiating treatment or closest available data to that time point, within one month. Our additional secondary outcome evaluated adverse events. We included any RCT of NRT of any delivery method, bupropion or varenicline. We included only RCTs of at least 1 years duration with chemical confirmation of smoking cessation, as there is reason to doubt patient self-report regarding addictions. Methods of assessing smoking cessation also vary from study to study. The most common method is self-report, however, this can have false cessation rates as high as 30%
Search strategy
In consultation with a medical librarian (PR), we established a search strategy. We searched independently, in duplicate, the following 10 databases (from inception to September 10, 2006): MEDLINE, EMBASE, Cochrane CENTRAL, AMED, CINAHL, TOXNET, Development and Reproductive Toxicology, Hazardous Substances Databank, Psych-info and Web of Science, databases that included the full text of journals (
Study selection
Two investigators (EM, PW) working independently, in duplicate, scanned all abstracts and obtained the full text reports of records, that indicated or suggested that the study was a RCT evaluating a smoking cessation therapy on the outcomes of interest. After obtaining full reports of the candidate trials (either in full peer-reviewed publication or press article) the same reviewers independently assessed eligibility from full text papers.
Data collection
Two reviewers (PW, PD) conducted data extraction independently using a standardized pre-piloted form. Reviewers collected information about the smoking cessation intervention tested, the population studied (age, sex, underlying conditions), treatment dosages and dosing schedules, the treatment effect at 1 year and at 3 months, the specific measurement of abstinence (sustained or point-prevalence), and the chemical confirmation methods. Study evaluation included general methodological reporting quality features including allocation concealment, sequence generation, blinding status, intention-to-treat, and appropriate descriptions of loss to follow-up. Quality of reporting could be considered as analogous to methodological quality if one assumes that failure to report on a component of study design (for example blinding) actually indicated that the component was not employed. We entered the data into an electronic database such that duplicate entries existed for each study; when the two entries did not match, we resolved differences through discussion and consensus.
Data analysis
In order to assess inter-rater reliability on inclusion of articles, we calculated the
We found 70 RCTs examining NRT versus control interventions (See Figure
Figure 1
Flowcharts of study searches
Flowcharts of study searches.
Table 1
Univariable meta-regression of NRT studies
Point estimate
Lower 95% limit
Upper 95% limit
Lower 95% limit
Upper 95% limit
Sequence generation
Allocation concealment
Planned to quit
Legend. The point estimate and 95% CIs estimate the unit change in the effect size, whenever the predicted covariate is present. The OR for the point estimates and 95% CI denote the likelihood of covariate affecting the trial effect size.
Additional File 1
Characteristics of NRT RCTs. Word file displays specific study details
Click here for file
Thirty-three studies evaluated NRT gum
All of the studies provided sufficient details to evaluate NRT versus control at 1 year
We also found 11 studies evaluating bupropion versus placebo
Additional File 2
Characteristics of Bupropion RCTs. Word file displays specific study details
Click here for file
Finally, we identified 4 studies evaluating varenicline versus placebo (See Figure
Additional File 3
Characteristics of Varenicline RCTs. Word file displays specific study details
Click here for file
Quality of methodological reporting
Of the 70 trials assessing NRT versus controls, studies were varied in reporting important methodological features, including: sequence generation (22/70), allocation concealment (11/70), blinding status (64/70), appropriate blinding (45/70), intention-to-treat (67/70), and appropriate descriptions of loss to follow up (44/70).
Studies assessing bupropion versus controls were similarly varied in reporting, including: sequence generation (4/12), allocation concealment (4/12), blinding status (11/14), intention to treat (12/12) and appropriate descriptions of loss to follow up (10/12).
The 4 studies assessing varenicline appropriately reported the methodological criteria, except 1 study that did not report the method of sequence generation
We combined 70 trials (total n = 28,343) assessing NRT versus controls at 1 year. The pooled OR of smoking cessation favored NRT over controls (OR 1.71,95% CI, 1.55–1.88, P =< 0.0001, I2 = 26.5%, Heterogeneity P = 0.02, See Figure
Figure 2
Random Effects Meta-Analysis
Random Effects Meta-Analysis. NRT vs. Controls at 12 months. I2 = 26.5%.
Fifty-nine trials (total n = 25,294) provided sufficient details to determine short-term effects of NRT on smoking cessation, as determined at 3 months. The pooled OR of the 59 trials was 1.98 (95% CI, 1.77–2.21, P =< 0.0001, I2 = 55.5%, Heterogeneity P =< 0.0001, See Figure
Figure 3
Random Effects Meta-Analysis
Random Effects Meta-Analysis. NRT vs. Controls at 3 months. I2 = 55.5%.
We evaluated the effect of bupropion on smoking cessation relative to adequate controls at 1 year in 12 trials (total n = 5,228, See Figure
Figure 4
Random Effects Meta-Analysis
Random Effects Meta-Analysis. Bupropion vs. Controls at 12 months. I2 = 71.5%.
When we evaluated the effect of bupropion on placebo at 3 months (11 trials, total n = 5,148), the OR was 2.13 (95% CI, 1.72–2.64, P =< 0.0001, I2 = 53.6%, Heterogeneity P = 0.01, See Figure
Figure 5
Random Effects Meta-Analysis
Random Effects Meta-Analysis. Bupropion vs. Controls at 3 months. I2 = 53.6%.
We pooled 4 studies assessing the effect of varenicline versus placebo at 1 year (total n = 2,528, See Figure
Figure 6
Random Effects Meta-Analysis
Random Effects Meta-Analysis. Varenicline vs. Placebo at 12 months. I2 = 20.5%.
Figure 7
Random Effects Meta-Analysis
Random Effects Meta-Analysis. Varenicline vs. Placebo at 3 months. I2 = 57.7%.
Two trials evaluated the superiority of NRT versus bupropion at 1 year
Figure 8
Random Effects Meta-Analysis
Random Effects Meta-Analysis. NRT vs. Bupropion at 12 months. I2 = 59%.
Figure 9
Random Effects Meta-Analysis
Random Effects Meta-Analysis. Varenicline vs. Bupropion at 12 months. I2 = 0%.
Figure 10
Random Effects Meta-Analysis
Random Effects Meta-Analysis. Varenicline vs. Bupropion at 3 months. I2 = 56.1%.
Using indirect comparisons
Figure 11
Indirect comparison between Varenicline and NRT vs Placebo at 12 months
Indirect comparison between Varenicline and NRT vs Placebo at 12 months. Bucher et al. indirect comparison methods [28].
Figure 12
Indirect comparison between Varenicline and NRT vs Placebo at 3 months
Indirect comparison between Varenicline and NRT vs Placebo at 3 months. Bucher et al. indirect comparison methods [28].
We anticipated variable between-study heterogeneity, considering the interventions used, methodological issues and measurement tools. Table
We additionally examined covariates in the bupropion trials (See Table
Table 2
Univariable meta-regression of bupropion studies.
Point estimate
Lower 95% limit
Upper 95% limit
Lower 95% limit
Upper 95% limit
Sequence generation
Allocation concealment
Planned to quit
Legend. The point estimate and 95% CIs estimate the unit change in the effect size, whenever the predicted covariate is present. The OR for the point estimates and 95% CI denote the likelihood of covariate affecting the trial effect size.
Adverse events
For bupropion trials, the following adverse events were reported significantly more in the active groups than control groups: dry mouth (9 trials
For varenicline trials, the following adverse events were reported significantly more often than in the placebo groups: nausea (4 trials
In this study we present the results of three main meta-analyses examining the effectiveness of various pharmacological strategies to improve smoking cessation. Our primary meta-analyses specifically examined the effectiveness of NRT versus control, bupropion versus control, and varenicline versus bupropion or placebo. We demonstrated the consistent effectiveness of each intervention in short-term and long-term smoking cessation.
Our findings confirm the effectiveness of two established pharmacological therapies, NRT and bupropion, to improve cessation rates. The primary new information from this review is the evidence of effectiveness of varenicline. This modality of treatment was identified to be more effective than placebo, bupropion and in indirect comparisons with NRT. However, this meta-analysis consisted of the fewest studies and although the studies were well reported and apparently well conducted, further studies comparing varenicline versus either NRT or bupropion will strengthen inferences about the superiority of this intervention. Nevertheless the initial findings are suggestive of the potential superiority of this latest pharmacological intervention.
This review has several strengths and some limitations that deserve mention. The strengths of this review include the comprehensive search strategy that improved the likelihood of identifying all relevant studies. Duplicate extraction of data reduced the potential for bias in this component of the synthesis process. By limiting this review to randomized trials we ensured that the included studies would have reduced likelihood of systematic error and therefore have high internal validity. Our use of meta-regression to identify sources of heterogeneity in the meta-analyses is a strength and demonstrated that several of the
Limitations of this meta-analysis include the potential for publication bias, specifically the possibility that small negative studies would not be published. We included only published trials so it is possible that other trials have been conducted and never published. However, it is unlikely that the presence of these studies would have altered the findings of the NRT meta-analysis given the large number of studies included. Similarly, since varenicline is a new agent and the studies synthesized were the first clinical trials evaluating its effectiveness, it is improbable other negative studies exist. We also limited our search to English language databases (although we would include non-English articles if identified) so the possibility of quality studies in other languages does exist. We used both direct and indirect comparisons to evaluate the relative effectiveness of agents. Head-to-head trials provide the strongest inferences regarding intervention superiority
There are several important implications of these meta-analyses. Identifying effective mechanisms to improve smoking cessation is essential. Smoking is the number one preventable cause of death in the world
The findings of this review point the direction for future studies. It is interesting that the three modalities examined have distinct biological mechanisms of action. NRT presumably works by reducing symptoms of nicotine withdrawal, thereby increasing the likelihood of smoking cessation. Bupropion is a weak dopamine and nor-epinephrine reuptake inhibitor. One of the primary symptoms of smoking cessation has been depressive symptoms and it has been hypothesized that smokers may be increasing central dopamine levels by reducing monoamine oxidase inhibitor activity
Competing interests
This study was supported by an unrestricted educational grant from Pfizer Global Solutions and the Canadian Institutes of Health Research (CIHR). The terms of the support from Pfizer and CIHR included freedom for authors to reach their own conclusions, and an absolute right to publish the results of their research, irrespective of any conclusions reached.
Authors' contributions
PW conducted the systematic searches, abstracted data, analyzed the data and contributed to the manuscript.
PD abstracted data, analyzed the data and contributed to the manuscript.
KW conceived the study, abstracted data, analyzed the data and contributed to the manuscript.
EM conceived the study, conducted the searches, abstracted data, analyzed the data and contributed to the manuscript.
All authors have read and approved the final manuscript.
The contribution of Gordon Guyatt is gratefully acknowledged. KW and EM are supported by the Canadian Institutes of Health Research (CIHR). Thanks to Pearl Raju for information systems assistance.
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Randomized, double-blind, placebo-controlled study of transdermal nicotine patch for smoking cessation
Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with six year follow up
A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation
Cue exposure treatment for smoking relapse prevention: a controlled clinical trial
Higher dosage nicotine patches increase one-year smoking cessation rates: results from the European CEASE trial. Collaborative European Anti-Smoking Evaluation. European Respiratory Society
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Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation: a randomized, double-blind, placebo-controlled trial
Effects of nicotine gum dose by level of nicotine dependence
Smoking cessation with four nicotine replacement regimes in a lung clinic
A randomized, double-blind, placebo-controlled clinical evaluation of a nicotine sublingual tablet in smoking cessation
Nicotine patches for pregnant smokers: A randomized controlled study
A comparison of a nicotine sublingual tablet and placebo for smoking cessation
Controlled trial of three weeks nicotine replacement treatment in hospital patients also given advice and support
Efficacy of a nicotine lozenge for smoking cessation
Smoking cessation with nicotine replacement therapy among health care workers: randomized double-blind study
Clinical trial comparing nicotine replacement therapy (NRT) plus brief counselling, brief counselling alone, and minimal intervention on smoking cessation in hospital inpatients
Smoking reduction promotes smoking cessation: results from a double blind, randomized, placebo-controlled trial of nicotine gum with 2-year follow-up
Controlled trial for smoking cessation in a Navy shipboard population using nicotine patch, sustained-release buproprion, or both
Smoking reduction treatment with 4-mg nicotine gum: a double-blind, randomized, placebo-controlled study
A placebo controlled randomized trial of the effects of phenylpropanolamine and nicotine gum on cessation rates and postcessation weight gain in women
Psychological intervention and antidepressant treatment in smoking cessation
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A comparison of sustained-release bupropion and placebo for smoking cessation
Bupropion for smoking cessation: a randomized trial
A multicentre, randomized, double-blind, placebo-controlled, 1-year study of bupropion SR for smoking cessation
Bupropion SR for smoking cessation in smokers with cardiovascular disease: a multicentre, randomised study
Bupropion SR vs placebo for smoking cessation in health care professionals
Varenicline for smoking cessation: definite promise, but no panacea
Data collection and questionnaire design: Smoking cessation in adults
The Health Benefits of Smoking Cessation: A report of the Surgeon General
Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials
Indirect comparisons: the mesh and mess of clinical trials
Mortality in relation to smoking: 40 years' observations on male British doctors
Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study
Effect of smoking cessation on mortality after myocardial infarction: meta-analysis of cohort studies
Smoking and mortality among older men and women in three communities
Bupropion: a review of its mechanism of antidepressant activity
The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Clinical-Style Validation, Regulation, and Quality Control...
Keep the Opportunities, Lose the Opportunists
Co-Sourcing Improves Pharmaceutical Laboratory Productivity
Loss of Lives in Clinical Trials...
A team of MIT chemical engineers reports that they have developed a fast and reliable technique for detecting methylated genes linked to cancer. They believe their method could offer a new way to choose the best treatment for individual patients.
"It's pretty difficult to analyze these modifications, which is a need that we're working on addressing. We're trying to make this analysis easier and cheaper, particularly in patient samples," said Hadley Sikes, Ph.D., the Joseph R. Mares assistant professor of chemical engineering and the senior author of a paper ("Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein") describing the technique in Analyst.
"Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases," wrote the investigators. "Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis."
In some cancers, a DNA-repair gene known as MGMT is turned off when methyl groups attach to specific locations in the DNA sequence, namely, cytosine bases that are adjacent to guanine bases. When this happens, proteins bind the methylated bases and effectively silence the gene by blocking it from being copied into RNA.
"This very small chemical modification triggers a sequence of events where that gene is no longer expressed," explained Dr. Sikes, adding that current methods for detecting cytosine methylation work well for large-scale research studies, but are hard to adapt to patient samples. Most techniques require a specific chemical step, bisulfite conversion: The DNA sample is exposed to bisulfite, which converts unmethylated cytosine to a different base. Sequencing the DNA reveals whether any methylated cytosine was present.
However, this method doesn't work well with patient samples because you need to know precisely how much methylated DNA is in a sample to calculate how long to expose it to bisulfite, according to Dr. Sikes.
"When you have limited amounts of samples that are less well defined, it's a lot harder to run the reaction for the right amount of time. You want to get all of the unmethylated cytosine groups converted, but you can't run it too long, because then your DNA gets degraded," she pointed out.
Her team's novel approach avoids bisulfite conversion completely. Instead, it relies on methyl binding domain (MBD) protein, which is part of cells' natural machinery for controlling DNA transcription. This protein recognizes methylated DNA and binds to it, helping a cell to determine if the DNA should be transcribed.
The other key component of Dr. Sikes' system is a biochip coated with hundreds of DNA probes that are complementary to sequences from the gene being studied. When a DNA sample is exposed to this chip, any strands that match the target sequences are trapped on the biochip. The researchers then treat the slide with the MBD protein probe. If the probe binds to a trapped DNA molecule, it means that sequence is methylated.
The binding between the DNA and the MBD protein can be detected either by linking the protein to a fluorescent dye or designing it to carry a photosensitive molecule that forms hydrogels when exposed to light. This technique, which cuts the amount of time required to analyze epigenetic modifications, could be a valuable research tool as well as a diagnostic device for cancer patients, noted Andrea Armani, Ph.D., a professor of chemical engineering and materials science at the University of Southern California, who was not part of the research team.
"It's a really innovative approach," Dr. Armani says. "Not only could it impact diagnostics, but on a broader scale, it could impact our understanding of which epigenetic markers are linked to which diseases."
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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Gia's Profile
Hello and welcome to my store! I hope that you will enjoy browsing through my creations, which are all designed and handmade by me in a smoke-free environment. Ever since I remember myself, I have always been an arts & crafts lover. Now I only make beaded necklaces in my spare time and I produce a very limited number of copies of each necklace. Due to my everyday contact with ancient artifacts, I am unconsciously inspired by the colorful Egyptian and Minoan designs. Many of my pieces echo the semiprecious gemstones used 5.000 years ago! All of pieces are made by genuine gemstones that won't fade; cheap plastic beads are never part of my repertoire. If you want me to design a special piece for you in specific colors, you can communicate with me and I will be very happy to do it!
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All parent member reviews for Flushed Away
Parents say
(out of 20 reviews)
age 5+
Review this title!
Not a poopy kid's movie!
If you have a thicker-skinned, movie-loving 4 year old or older, go see Flushed Away! The best animated movie I've enjoyed in a long, long time. I'd call it an "Action/Adventure" animated film, very action-packed, layers of detail in the scenes and plenty of adult references to other movies etc, to keep Mom & Dad's interest. I took my 4 & 5-1/2 boys and a 6 year old girl today, and we all really enjoyed it. This is not a good movie for kids who haven't ever been to the movies before; way too much going on if they're not used to a big screen experience. But I will look forward to buying this DVD and seeing it over & over & over if necessary, it's very fun! The movie title is the most potty talk you'll get from the movie, some over-their heads references that are hysterical IMHO, no swear words besides "idiot" I can think of, some cartoon-type "violence" and high-action adventure/race/escape scenes, but I don't feel there was anything inappropriate for my 4 or 5 year olds. It was so nice to go to a kid's movie and enjoy it as much as the kids did.
Was this review useful?
Tedious, but not Terrible. Dissapointing, though...
If you are looking for some family time, go to a park instead, and watch this as a rental. Lots of bathroom humor, lots of burping, and body function humor. My 4 and 6 year olds thought those parts hilarious, though, plus the brit's refer to the rear as "Bum" which is easier on the ears.The fact the rudeness is in a british accent is helpful, too, cause lots of kids won't understand it anyway. Additionally, much of the humor was in the backgroud, i.e. a boat named "Floater,"etc, so many kids won't even get it. (Story takes place in a sewer)The annimation is great, and the characters are sweet, but really, the story is weak, a real disappointment from Wallace and Grommet. My 6 year old definately got bored, though my 4 year old didn't. She said afterward it was too long, and I agreed that parents will feel all 82 minutes of this one. Anyway, there you go...a better rental than spending the $ at the theatre...
Was this review useful?
Not bad for the kids but a bit boring for the adults
I took 4 boys to this movie ages 3-8 and they all enjoyed it. While I thought the animation was great and I loved the British accents, I was a bit disappointed with the movie as it didn't hold my interest like other Wallace & Gromit movies. I would recommend you save your money and rent it on DVD - better value for your money, especially with theatre prices these days.
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ha! ha! that was funny!
that movie was funny!! though if u can't stand gross scenes which there are some in the movie like where Roddy and Rita do the gross handshake when making the deal(i don't even know why they made it a gross handshake), don't watch it. I liked the part where the French frogs came in the scene, especially the mime. There is a kissing scene where Roddy accidentally kisses a bride rat on her wedding day. Theres also a hugging scene in there toward the end when Rita gets the ruby and the emerald, don't let your kids see the movie if you don't think any romance is appropriate for your kids. Otherwise, this movie is great!
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Not appropriate for young children
My son is 4 and I found the potty humor and sewer situation highly inappropriate as well as the violence and premise that it is ok to steal. The main character getting his private parts cracked over and over was not the thing I want my 4yr old exposed to. I would have had no problem with it if my son were older but this movie is not age appropriate for young children.
Was this review useful?
Very fast paced!!!
You might want to see this twice, very funny and different comedy, if you can deal with the British accent. No bad language.
funny fun for all ages
Truly entertaining and funny
Flushed Away is truly one of the best Aardman Entertainment offerings. It is very funny with all the great incidental quirky humor a fan expects from the media firm. The characters have a lot of heart, good action and funny-funny-funny. You can see Nick Park's influence in the movie especially. Not a huge box office hit, but an A+ rental.
Lots of fun for all ages
My five year old loves it, and I do too. I think the female lead is a positve role model for girls since she is very independent, and also cares deeply for family, and honors committments. It's a very clever movie.
What other families should know
Great role models
Great movie from Dreamworks. Lots of funny moments. It does get a little violent for some little kids, but overall it is pretty tame
What other families should know
Too much violence
What other families should know
Great role models
This is the way Disney wants our kids to behave?
Yes, it says it is PG. I guess that is "fair warning" but with all of the promotional "Happy Meals" and advertising aimed at small children, I was very disappointed to see the movies characters burping and farting. My 7 and 6 year old kids thought it was funny but then began copying the on-screen behavior they had just witnessed. I now have to constantly remind them that this behavior is not acceptable in our home...and I wish it were not acceptable in a "Disney" movie.
My 3 year old and I both laughed out loud.
I took my three year old to see this. I expected to be bored, but found myself laughing out loud. My three year old thought the frog was a little scary as the "bad guy." But otherwise liked it alot and asks to watch it over and over now that it's out on video.
Fun movie for entire family!
My 3 and 5 year old love this movie. one of their favorites.
We loved this movie, lots of humor for adults too!
Entertaining for young kids
My 3 yr old son loved this movie and his daddy & I were somewhat entertained as well. Unfortunately, its not as good as other animated films out there now, but the singing slugs who appear periodically throughout the film are very funny. I actually looked forward to the slugs and would have advocated them being in the movie more. There's a bit of slap-stick humor in it, but I wouldn't consider it inappropriate for kids . . . it was mild if you compare it to what I watched as a kid, like Bugs Bunny or Tom & Jerry. And if you don't want you kids seeing tiolet or sewer humor/references, then its not for you, but then again the title 'Flushed Away' should have told you that . . . .


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I bought these sheets for our guestroom. We have used them and washed them twice. They come out of the dryer with very few wrinkles, which I have been able to press out with my hands, while making the bed. They are crisp and comfortable, and I love the bright blue color and funny little yellow fish!
I wanted a fun print to match with an all white bedding scheme and these sheets fit the bill. Tommy Hifliger usually does. The cut of the sheets is ample with deep pockets. The quality is excellent and the material is comfortable. It is more on the crisp side than the cozy side but it is not scratchy at all. Instead, it will look neat right after having slept on it. That's a feature I like.
- How did the color on site compare with the actual product? Excellent
- Please tell us about the quality of the product. Excellent
- How accurate was the on site description of the product? Excellent
The finish makes them slippery. It never washes out. Generously sized tho.
Doesn't pill and very warm.
Feels soft enough and pockets are deep. Fabric seems to be of good quality and hasn't piled since the past few washes.
Nice, bright sheets for the price. They're a bit thinner and rougher than I thought they'd be, but fine for the price.
These sheets are rough, no matter how many times I washed them! Our mattress is a pillow top and these sheets were to short.
My daughter took one look at my new sheets and said they'd be PERFECT for her new apartment. So, what's a mom to do? I really liked the sheets but made them a housewarming gift. My daughter is very happy with them. She likes how they brighten her room and feel soft and cozy.
Love the Ticking Stripe design. Fabric feels nice and not scratchy. Looks great in the room and very versatile....can be casual or not.
I have not used these on the bed yet, but, the package seems a little thin, so, assuming the sheets are too, but, to early for judgement yet. As I have stated in another review, I ordered 2 Tommy Hilfiger products; sheets (2 sets and comforter) and a mattress pad. All three items are just as pictured and described; colors and etc. I have always got good results from Hilfiger products, and this order came in THREE days and it right here at Christmas; I was so surprised and pleased!! I love being able to read customer reviews as bedding is something you don't purchase often, and is costly, and its great to see what other people are happy with. Thank you Overstock, for great value for my money.
Very impressed with all the Tommy Hilfiger bedding I have purchased through Overstock.com! They are superb!
the tag & packaging reads 'made in pakistan', a bit of a disappointment for tommy hilfiger. i was upset that i had bought a fake item, but it turns out it's just outsourcing.
the most confortable sheets I ever sleep on..And the most best price.
I bought this set for my guest room and I am very happy with it. I bought the ticking stripe version and it will never go out of style. It is not quite as soft as my other sheet sets, but I hope that after it continues to get laundered it will get softer. It does tend to be a little wrinkled, but it smooths right back out again, so it's not that big of a deal.
Loved the blue stripes of these sheets. Good quality of fabic.
I love patterned sheets and these are stylish and look great in our room. They are good quality as well.
Cozy now, but as I wash everything before being used, I as surpassed they were so stiff...until I went to put my cotton pajamas on, which were scratching me like crazy..then realized the washing machine had not gotten all the soap out. Now that they've been re-washed, they are cozy and I like the feel of the cotton. I've been tire f plain cored sheets so am enjoying the strips very much. Skip Reistad
I am really impressed with the quality of these sheets. My husband has Alzheimers and is incontinent so sheets are washed every day. I have three sets; thus, every third day these sheets are in the wash. They have performed very well, actually better than others I use which cost considerably more. The pockets are not deep enough for my bed, but my mattress is exceptionally thick because I have a four inch foam topper on the mattress.
The sheets are very well, very soft, and great color.
We got these sheets for the guest bedroom and I've asked our guests what they think of them and have yet to get a bad review. The first couple of times we washed them they came out smelling funny, almost like cat pee. But once put through the dryer they were fine. Very odd. We got the Tommy Fish pattern and it is adorable. I love putting these sheets on the guest bed every time!


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This week we bring you fictional accounts of what it's like to bridge two worlds—as a young person becoming an adult, and as an immigrant navigating different identities.
With more than 50 million individuals living in the United States, Latinos and Hispanics comprise the largest minority group in the country. Based on the 2014 Census estimate, almost 30% of individuals living in Denver are Latino and/or Hispanic. With such large numbers, it should come as no surprise that this group is anything but homogenous -- from newly sworn in U.S. citizens to second generation immigrants like myself, everyone has a very different story to tell and experiences had along the way to finding their own place in the United States.
Naghem S., a Plaza staff member, writes:
On Saturday September 19, 2015, the Rodolfo "Corky" Gonzales Branch Library hosted the Immigrant Bazaar. Merchants from all walks of life showcased their beautiful homemade goods. Along with tasty food and a gorgeous late summer day, this event is one to be remembered for days to come. Sitting under tents and enjoying the energetic environment, vendors supplied customers with an extensive variety of food, art, clothing, jewelry, and film.
Personal stories are fascinating. They enliven history, putting events into a context we can understand. They bridge the gaps between our own experiences and those of others, as we see common human concerns arise in circumstances vastly different from our own. More than anything, personal histories help us to empathize with people whose lives we may have never imagined.
March is Women's History Month, and a time to explore the experiences and contributions of immigrant women here in America.
Both the Migration Policy Institute and the American Immigration Council offer demographic information on immigrant women, detailing country of origin, occupation, and education level.
What an enjoyable story. The Boston Girl is about Addie Baum who is now 85 and is being interviewed by her granddaughter Ava. Addie has had her share of deep sorrows and great joys. She was born in 1900 to immigrant parents and has lived through many changes – cultural,...
Immigration is in the news, not just here in the U.S. but around the world. This week we bring you a selection of international films that explore the immigrant experience, both here and across the globe.
Desiree S. of the Ross-Barnum branch writes:
Moving away from one's home can be one of the most challenging life experiences. Having come to Denver via Oklahoma City myself just one year ago, I can certainly vouch for there being a period of readjustment -- one has to discover all new neighborhoods, meet all new friends and perhaps reconnect with old ones. In short, one must create an everyday existence that is different from what was there before. But what about adjusting to a place where both the language and the culture are completely foreign?
Each year on July 4th, the Carnegie Corporation of New York celebrates by honoring a group of distinguished American citizens, taking out a full page add in the New York Times. The people featured are writers, chemists, architects, entrepreneurs, chess masters, actors, astronauts and cellists. They are athletes, politicians, doctors, and engineers. What do all these people have in common, aside from their impressive accomplishments and their status as U.S. citizens?
The Denver Public Library's Plaza program is featured in the May 2014 issue of American Libraries Magazine!
Though the article, "Connecting Latinos with Libraries," focuses particularly on Spanish-speakers, Plaza programs are designed to engage international migrants from all over the world, as well as other community members, regardless of their background or native language.
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text:
Helen Thomas' 'Zionist' Comment Leads University To Pull Honor
Wayne State University won't be bestowing any more diversity awards named for Helen Thomas following more controversial remarks by the former dean of the White House press corps.
The university pulled the honor, the Helen Thomas Spirit of Diversity Award, after the 90-year-old said this week that "Congress, the White House and Hollywood, Wall Street are owned by Zionists. No question, in my opinion."
Thomas made those incendiary comments, according to a Detroit News report, before a diversity conference Thursday.
In an earlier report, the newspaper quotes a Wayne State official explaining the obvious, that the university had to put distance between itself and its famous alumna.
"The controversy has brought a negative light to the award, which was never the intent of the award," said Matthew Seeger, interim dean of the College of Fine, Performing and Communication Arts.
Thomas was forced to retire from Hearst Newspapers earlier this year after making comments about Israel in which she suggested Jews leave "Palestine" to Arabs and head to Europe and the U.S.
The former reporter is of Lebanese descent. She became known during her later years in the White House press corps for jousting with presidents, particularly over the U.S.'s supportive policy toward Israel.
During the Iraq War, her following grew among critics of the invasion and occupation ordered by President Bush, with her assertive questioning of the president and other officials.
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Hi There,
I was doing searching last night but couldn't find anything to help me filter out a single page to be non-HTTPS without changing the plugin.
For all those that want to make your whole site except for /example/ HTTPS insert the following code into the URL Filters:
Just replace "example" with the page/link you require.
Hope this saves people some time, and should probably be put as an example expression?


text:
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Your brand is a representation of who you are, what you stand for and what you bring to the world.
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Design is not just what it looks like and feels like. Design is how it works.
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You can design and create, and build the most wonderful place in the world. But it takes people to make the dream a reality.
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Design is thinking made visual.
— Saul Bass
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My content width is 590px, but my Youtube videos keep showing up wider than that (640px) and break my layout.
I was using auto-embed initially, but changing the max width under Settings > Media didn't help. I then tried to use the embed shortcode with a width declared, but that didn't work either.
I'd like to avoid having to use an object or embed HTML tag, since I know that TinyMCE doesn't play nice with them.
Can anyone offer any suggestions? Is this a problem with my theme?


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The Myths of Mexico and Peru
by Lewis Spence
Creation myths, legends of Quetzalcoatl, Tlaloc, the Rain-God, The Bird Bride, Thonapa, and many more. Over 60 photos and illustrations.
Paperback, 448 pages
Published January 9th 1995 by Dover Publications
(first published 1913)
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Oct 28, 2007 Nathan rated it liked it · review of another edition
Recommends it for: Conquistadors
Initially, I thought this book would fulfill my need for myths and folk tales of the American aborigine, but I was actually wrong. The myths here and tales are too short to carry one away into another past, but they still are interesting enough to allow one a little understanding into the background of Latin American heritage. This is a good read for true fans of that nature, otherwise, you must go elsewhere.
May 28, 2012 Dione Sage rated it liked it
Shelves: folklore-mythology
I love reading about myths and legends. This is one of the better books on that topic (specific for Mexico and Peru) because it has pictures, glossary and references in it which makes researching a little easier.
After graduating from Edinburgh University he pursued a career in journalism. In 1899 he married Helen Bruce. He was an editor at The Scotsman 1899-1906, editor of The Edinburgh Magazine for a year, 1904–05, then an editor at The British Weekly, 1906-09. In this time his interest was sparked in the myth and folklore of Mexico and Central America, resulting in his popularisation of the Mayan Popul ...moreMore about Lewis Spence...
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