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NFL to relocate Bills home game against Jets
New York Gov. Andrew Cuomo said Thursday that it would be "impractical" at this time for the Buffalo Bills to host the New York Jets.
Sponsored by:
New York Gov. Andrew Cuomo said Thursday that it would be "impractical" at this time for the Buffalo Bills to host the New York Jets.
A person with knowledge of the negotiations says free agent designated hitter Billy Butler and the Oakland Athletics have agreed to a $30 mi…
Dakari Johnson scored 11 points, Andrew Harrison had 10 and No. 1 Kentucky used a dominant defense to blow out No. 4 Kansas 72-40 in Tuesday…
Champ Bailey said goodbye to the NFL on Tuesday after signing a ceremonial one-day contract with his beloved Denver Broncos.
Ron Baker scored 21 points to lead No. 11 Wichita State to a 71-56 win Tuesday over Memphis State.
The NFL has suspended Adrian Peterson without pay for at least the rest of the season.
Bruce Weber made sure his team understood Missouri-Kansas City's upset ability, having won its season opener at Missouri.
A new sport is gaining a toehold on golf courses in Myrtle Beach, South Carolina.
Wichita learned on Monday that it will host the first and second round games for the NCAA men's basketball tournament in 2018.
Federal drug enforcement agents showed up unannounced at least one stadium Sunday to check an NFL team's medical staffs .
Click here for photos from the Chiefs victory over the Seahawks in Week 11
The Kansas City Chiefs stopped the Seattle Seahawks on fourth down three times late in the fourth quarter Sunday.
The KU football team came close to its first regular-season win over a top-five team since 1995, but wound up losing to TCU 34-30.
Ex-Shocker Xavier McDaniel returned to his college town this weekend for a worthy cause and also checking out his former team.
Cruising to a 71-54 victory over New Mexico State Friday night was anything but inconsistent for the No. 11 Shockers.


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IgNobel Awards Ceremony
It's time again for our annual broadcast of highlights from the IgNobel Awards ceremony. This year, the awards feature the invention of the combover, whether the "five-second rule" really keeps dropped food clean, the physics of hula hooping, and a peace prize to the inventor of karaoke. NPR's Ira Flatow takes a look at science that cannot — or should not — be reproduced.
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303 reviews | 4.4 out of 5
Thanks for offering me the 3 Year Service Plan for my New 42" VIZIO HDTV.
I have to base my review on my expectations because I haven't had to call on it yet. I've had my 40" Element flatscreen TV set up for about four weeks. The sound was weak when I had it on the TV stand, but since I mounted it on the wall, it sounds much better but with some shows it's still low. Overall, the quality, the value, and the features of the TV all meet my expectations. I'm glad I got the 3 year warranty JUST IN CASE something goes wrong.
I purchased a 42 inch Sanyo tv in July 2013. I paid 24 dollars for the warranty. Well in June 2016 my tv screen went black. It had sound but no picture. Remember here I was 2 weeks away from warranty expiring. I call Asurion, I tell them what's up with the tv. They say they are sending me a box to ship it to them. About 3 days later I get the box via ups. I boxed up the tv and took it to ups, postage paid by Asurion. That was Thursday when I shipped it. Monday I get a call from them stating, they can't fix it. The woman told me I will be receiving a email within 24 to 72 hours. I received the email on a Tuesday. I received a E gift card for full purchase price including tax that I paid. I took my phone to Walmart that same day. I picked out a new tv, took it to register. The cashier scanned the barcode off the E gift card on my phone. Everybody lived happily ever after. Oh you better believe I purchased another service plan.
The best feature of this plan is that it goes into effect AFTER the one year manufacturer's warranty expires, so the TV is covered for a total of 4 years. The price of approx $45 for 3 years is also far below what can be found elsewhere, including at SquareTrade. At Best Buy a 2 year warranty would be nearly triple the cost and it goes into effect upon purchase. At SquareTrade, a 3 or 4 year warranty also goes into effect upon purchase. So what you would be buying at BB or ST is really an additional year (BB) or 2 or 3 additional years (ST) beyond the mfg's warranty. This warranty was a major factor in my decision to buy the Sony TV at Walmart. In the store, you can buy a 2 year warranty, but a 3 year warranty is available online only. As to how good the warranty is, only a warranty claim will determine that and I hope that I never need to find that out. By and large, this warranty is, compared to all the others, the best value.
I bought this warranty because I seen that there were some customers that had trouble with the TV that was purchasing. To start with you can not see a sample of what is covered or how a problem is to be handled till after you purchase the warranty. Also, you do not get a hard copy of the warranty, you must purchase it and they email it to you and you then must print it out if you want a copy. To have any warranty work done, you must first call them and get permission to have it serviced, and they will not cover anything while there is still a factory warranty in affect, and from the way the extended warranty reads, it doesn't matter if the factory warranty fixes your problem or not, the extended warranty still won't fix it till the factory warranty is completely finished. Also, it doesn't list any local shops in the warranty that I received, but does give a number to call so they can tell you where to send the TV for warranty service.I may have not have bought this warranty if I had been able to read a copy and see it's limitations before hand.
This plan is EXCELLENT! Here's what you should know: 1. This plan DOES NOT kick in until after the manufacturer's warranty expires (typically one year). Basically you're buying yourself 2 extra years of warranty that is actually BETTER THAN the manufacturers. 2. Yes you have to send your product somewhere, but shipping is completely paid for. They also make it easy to track the repair by giving you shipping tracking numbers and a website to see what's happening with your repair. 3. If they can't fix it, they will replace it. By replacing I mean a new ____ (whatever you got) or a check for the original amount you paid plus whatever you paid in sales tax. 4. Once you send something in, just expect to not have it for a few days. I sent an iPod in, for example, and got it back in about 2 weeks. The wait was worth it as the battery, hard drive, and outer shell were replaced with new ones! It makes too much sense to ignore. Please, if you can live without your purchase for a few weeks should it break, I'm practically begging you to get this plan. I promise you'll be sorry someday if you don't!
Bought this warranty with a 50 inch element TV. After acquiring several dead pixels, I contacted the warranty company to initiate repair. After a week wrangling with the repair company to come to my house and look at my TV, they couldn't do anything on site and took my set to the shop. A week later, after calling them myself, I finally get an answer from them saying the TV was non repairable, I should of gotten a call from the warranty folks to discuss replacement options. I call the warranty people, they said an email was sent to me, but "oh wait, we don't have your email on file." I provided my email and another phone number. Was told I'd be contacted in 1 business day. Two days later I called again, same conversation. A day later I called, same conversation. After the weekend passed I called and had the same conversation, but told them I keep calling and getting no follow up. She says "we tried contacting you but were unable to leave message". This is a lie as I was receiving messages from another company at that time, and they couldn't send an email this time? She says they will be in contact with me in 2 business days. I'm really sick of this warranty company and the junk service.
Purchased Panasonic 42 inch TV for my 98 year old parents for Christmas. After using the TV for about 4 weeks, the closed caption went out (with 98 years olds that are almost deaf) this is not good. Called Panasonic and they advised it was my cable box, took box back to Verizon and they said it was my TV. Had no luck with Panasonic, So I e-mailed good ole "Walmart" and as usual they stood behind their products. Within 1 week I had a new Panasonic TV, that the closed captions works and they also picked up the defective one. I would highly recommend all purchases go thru Walmart as they are the best for following thru on complaints and replacing products. A big Thanks to WALMART
The picture on our Vizio LCD TV went out last summer 3 days after a tree fell on our house. The house was repaired before the TV was. It took almost two months to have the television fixed. I was told the part was back-ordered. I was told the part wasn't being made anymore. I was told about a thousand different things. I made call after call to the warranty company and the service center. The service center never knew what the warranty company was doing and the warranty company never knew what the service center was doing. I had to be person to get them to talk to each other if I wanted any hope of getting my television fixed. Guess what? The same television went out again 4 days ago. The protection plan was still valid so I called and was told by the warranty company that someone would be out this morning. Well, no one had called or shown up by 10:30am so I call the service center and they state they never received anything to set up an appointment and the earliest available time they have is 8 days from now. I called the warranty company back and they told me that when I was told 4 days ago that they would come out today that it wasn't a "guaranteed" appointment. When I asked "Was anyone ever going to call and tell me?" I didn't receive a response. Then after I voiced my displeasure some more the rep offered to put me on hold and call another service center to see if they could get there more quickly than 8 days, I was disconnected. Was it on purpose? I can't say. What I can say is that you may get your television fixed for free but at a significant cost of time and patience. These people care nothing about customer service and it is obvious.
The price of the care plan is worthwhile for the coverage with a few exceptions. Not all of the deatils of the plan are available until you purchase it, then print it yourself. Coverage begins after the manufacture warranty. All service during the manufacture warranty must go through manufacturer. Plan not used yet. Cost is less than 15% of original price. Seems worth it at this point.
Purchased a 32" tv with the 3 year warranty back in 2007. Last month our tv started acting up. Placed one simple phone call and got a claim started for warranty service. The process was simple and quick. Unfortunately after having the same repair issue twice within two weeks, we placed another call and we had our tv REPLACED FOR FREE!! I highly recommend buying the extended warranty through WalMart and NOT the manufacturer.
I urge everyone who buys a tv to purchase the extra warranty. They stand behind the product and will fix or replace the tv. I know this from experience. Tv's today are so expensive, you can't afford not to buy the extra warranty!
The TV repair company tried to install a old refurbished part in my LG 55 inch TV. I requested them to install a new part or if they are installing a old part leave my original part with me. My PCB board was just giving me issue once in a while and I could not trust that old PCB board Precision Services(3rd party repair company sent by insurance company) was trying to install. They denied my request and closed the claim without repair. Never buying Walmart's extended warranty again for my electronic items.
I purchased one of these on another tv that required this service after 2 1/2 years of service. There was no problem with the service. This extended warranty is so cheap to buy at Wal-Mart that it is a no brainer.
Just in case it's not clear to anyone buying this TV warranty - if your TV is smaller than 37", they do not send a technician to your house. Instead, they mail you a box and then you package up your TV and send it off for repairs. Expect to have no TV for upwards of 3 weeks.
I bought this TV in 2013, bought the warrenty and was misguided as to what was covered. Cashier in electronics told me nothing about the warrenty when I asked only that he didn't know. The TV had a terrible stand that wobbled and finally fell over and cracked the screen. Called originally was told nothing could be done! Called today when it fell and still told nothing they could do! I PAID FOR A WARRENTY THAT COULD NOT BE USED!!!! DO NOT BUY ELECTRONICS FROM WALMART!!! Ever! This company is for profit only they do not care about their customers!! NEVER SHOPPING AT WALMART AGAIN! They don't even have good deals on tvs!!! So done
I got a new Panasonic 50"plasma just had to use the warnty called said tech would b out then Waited as no tech I had to call them back now there is nobody comming they where sending a check to cover the TV that was a month almost two ago still waiting sure miss my big TV down to watching are 40"seems tiney
i have used the extended warranty after owning my hd tv 2 years and the warranty is great and they do take care of you and didn't cost me even a penny don't buy without the extended warranty
I had a 46" vizio for 2.5 years and the screen had a black spot on it that took up probably 33% of the screen. Turns out the panel was going out. I forgot about the warranty and thought I was going to have to buy a new TV. Grateful I kept the paperwork. Make a long story short they cut me a check for what I originally paid 2.5 years ago. They offered several very nice TV's but I wanted to be in control over what I got. It worked out great. I bought a new TV with the warranty.
Great price for this plan, but... But I find it OUTRAGEOUS that not even a piece of paper is sent out to confirm purchase of this plan!!!


text:
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The wave (original 1981; edition 1981)
by Todd Strasser
Work details
The Wave by Todd Strasser (1981)
No current Talk conversations about this book.
"In spring 1967, in Palo Alto, California, history teacher Ron Jones conducted an experiment with his class of 15-year-olds to sample the experience of the attraction and rise of the Nazis in Germany before World War II. In a matter of days the experiment began to get out of control, as those attracted to the movement became aggressive zealots and the rigid rules invited confusion and chaos... The original experiment was named "The Third Wave" and occurred at Cubberley Senior High School in Palo Alto, California, in March/April 1967. Teacher Ron Jones wrote a short story about the experience that was published in spring 1976. This was followed by a TV movie ("The Wave") by famed producer Norman Lear on October 4, 1981. The subsequent 1981 book "The Wave" is a novelization of the Lear movie, and was written by Todd Strasser (aka Morton Rhue)." http://www.thewavehome.com/
I remembered seeing a movie/documentary about this at school in the 1980s so when my daughter brought 'The Wave' home from school it sounded familiar so I read the book. I thought it was well done, a book that teens could get through relatively quickly whilst understanding the concepts and deepening their understanding of Nazi Germany.
I'm not quite sure why I've heard good things about this one. It does tell an important story about the dangers of mindless group-think but it could have been written much better. It's not good when you are reading something and it reminds you of stories you wrote during your own school days.
One things that really bothers me about books written for teens is that some, including this one, write in a style that is too simplistic. Thankfully the assumption that teens aren't able to understand more sophisticated styles is slowly being overturned. Much like Ally Condie (please don't flame me saying that her series is awful, it's definitely better written than this) did a retelling of The Giver, I hope that someone can one day take this idea and retell it with with more compelling characters and hopefully a bit more dramatic tension.
This was an easy read considering the size. I feel that it took a while to get interesting and as I read it was almost like a roller-coaster, going from fascinating to dull. I did learn quite a lot from it though so I'm glad that I read it. And when I was at an interesting part, I couldn't put the book down. I was stuck between 3 and 4 stars but just decided to put three, probably because I wasn't crazy about the ending and the endings are my favorite parts.
Powerful true story that shows what happens when a school teacher tries to help his history class understand the power of 'belonging'. From learning about the Third Reich the teenagers go to establishing a movement that will take on a life of its own and fight back against anyone who dares to threaten it. Scary - especially as it's based on fact.
A compelling story about how Nazi Germany could have been created--how the minority controlled the majority, and how the majority allowed themselves to be controlled. It's based on the true story of The Third Wave experiment, which demonstrated fascism as a part of teaching about WWII.
But the writing of this book. Oh, the writing. It hurts. It should be noted that in tiny print on the copyright page, it does note that this is a novelization of a teleplay that was an adaptation of the original teacher's essay about the experiment. Once you're that far removed, I'm not sure it's possible to write a good book, but oh, the writing is just bad. And I can also make some allowances for it being 1981 when he wrote it. The second sentence of the book is "She was a pretty girl with short light-brown hair and an almost perpetual smile that only disappeared when she was upset or chewing on Bic pens." (Sentence 1 established that she was, in fact, chewing on a Bic pen.) And the whole book sounds like that.
It's a valuable book for a curriculum, but I do wish we could have students read the original essay instead, just as a matter of literary quality.
References to this work on external resources.
Wikipedia in English (2)
Amazon.com Product Description (ISBN 0440993717, Paperback)The Wave is based on a true incident that occured in a high school history class in Palo Alto, California, in 1969.
The powerful forces of group pressure that pervaded many historic movements such as Nazism are recreated in the classroom when history teacher Burt Ross introduces a "new" system to his students. And before long "The Wave," with its rules of "strength through discipline, community, and action, " sweeps from the classroom through the entire school. And as most of the students join the movement, Laurie Saunders and David Collins recognize the frightening momentum of "The Wave" and realize they must stop it before it's too late.
(retrieved from Amazon Thu, 12 Mar 2015 18:11:14 -0400)
A high school experiment to test social interaction backfires when an elitist group is formed. What starts as an innocent experiment brings terror to a high school. The Wave is based on a true incident that occured in a high school history class in Palo Alto, California, in 1969. The powerful forces of group pressure that pervaded many historic movements such as Nazism are recreated in the classroom when history teacher Burt Ross introduces a "new" system to his students. And before long The Wave, with its rules of "strength through discipline, community, and action," sweeps from the classroom through the entire school. And as most of the students join the movement, Laurie Saunders and David Collins recognize the frightening momentum of The Wave and realize they must stop it before it's too late.… (more)
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text:
Research Article
Suppression of visceral adipose tissue by palm kernel and soy-canola diacylglycerol in C57BL/6N mice
Version of Record online: 23 SEP 2013
DOI: 10.1002/ejlt.201300111
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Lipid Science and Technology
Special Issue: EuroFedLipid Highlights 2013
Volume 115, Issue 11, pages 1266–1273, November 2013
Additional Information
How to Cite
Tang, T.-K., Beh, B.-K., Alitheen, N. B. M., Lo, S.-K., Lee, Y.-Y. and Lai, O.-M. (2013), Suppression of visceral adipose tissue by palm kernel and soy-canola diacylglycerol in C57BL/6N mice. Eur. J. Lipid Sci. Technol., 115: 1266–1273. doi: 10.1002/ejlt.201300111
Publication History
- Issue online: 8 NOV 2013
- Version of Record online: 23 SEP 2013
- Accepted manuscript online: 2 SEP 2013 06:27AM EST
- Manuscript Accepted: 21 AUG 2013
- Manuscript Revised: 4 JUL 2013
- Manuscript Received: 27 MAR 2013
Funded by
- Sime Darby Research Sdn. Bhd.
- Abstract
- Article
- References
- Cited By
- Enzymatic reaction;
- Lipid;
- Obesity;
- Palm
The present study investigated the health effect of two types of diacylglycerol (DG) produced from (i) palm kernel (PK) oil of medium-chain saturated fatty acids and (ii) soy-canola oil (SC) blend of long-chain unsaturated fatty acids in C57BL/6N mice. As compared to diet containing 30% PK triacylglycerol (TG), 16 wk feeding trial on C57BL/6N mice with a diet consisting of 30% PKDG and 30% SCDG significantly (p<0.05) reduced the fat accumulation in epididymal and retroperitoneal regions. Serum glucose, cholesterol, leptin and insulin levels were significantly (p<0.05) suppressed in PKDG- and SCDG-fed mice. In terms of gene expression, PKDG diet induced expression of acyl-CoA synthase long chain (ACSL) and acyl-CoA synthase medium chain mRNA in the small intestine of the mice while SCDG fed mice upregulated ACSL in liver and small intestine. This suggests that the difference in fatty acid composition of DG may potentially induce β-oxidation in different organs in mice. Besides, expression of apolipoprotein B mRNA were reduced in mice fed with PKDG and SCDG, indicating the ability of PKDG and SCDG to reduce LDL levels. In conclusion, structural differences between DG and TG markedly influenced the metabolism of lipids in the body while fatty acid composition has only showed a minor effect.
Practical applications: Medium chain type of DG oil, if proven to have similar effects to long chain type DG in this study, can be incorporated into food for health purposes and can replace conventional cooking oil as healthy functional cooking oil.


text:
Skip to comments.Psychiatrist courts controversy, says homosexuality is unnatural
Posted on 01/29/2014 7:30:19 AM PST by James C. Bennett
Former president of the Indian Psychiatric Society Dr Indira Sharma has courted controversy by claiming that homosexuality is unnatural, a statement made three days ago at an annual meet of psychiatrists.
The LGBT community has brought "talk of sex to the roads", she told Times of India. "Heterosexuals don't talk about sex. It's a private matter," she told Times of India.
The report quoted a psychiatrist who attended the summit as saying Sharma's speech took a condescending approach towards homosexuals. Sharma denied to TOI that she called for "homo clubs" to be shut down.
She said her speech was about homosexuals who were uncomfortable about their sexuality and wanted to change their sexual orientation. "She added that those comfortable with their orientation should be made aware that their behaviour was causing a lot of uneasiness in society," the report said.
Sharma, who teaches at Banaras Hindu University, reportedly stirred a hornet's nest at last year's annual meeting too, when she suggested that early marriage for women was advisable.
Crazy that saying homosexuality isn't natural causes controversy.
Society decides what is natural and normal.
Attitudes are generally swinging away from this man's opinion.
Yes, I said "swinging" deliberately.
Obvious truth is obvious.
Uh...the PLUMBING defines that it is NOT NATURAL!!!
It's as natural as trying to fly an airplane with both wings on the same side.
I nominate him for Surgeon General .
The sole purpose of a species is to procreate. Given natural selection, homosexuals should be extinct unless they can find other ways to propogate their lifestyle.
NBC's director of entertainment, a homosexual himself, is ordering a program from ellen degenerat since all the other homosexual shows fell.
Suprised the homsexual all obama news channel is not talking about this.
That's a 'her'.
Speaking truth to ... perversion.
We must never lose sight of the truth that we are not wrong in opposing homosexuality; homosexuals are wrong in promoting it.
Well, duh. Anyone who prefers the septic system over the babymaker is insane.
We don't determine what is right or natural by taking a poll.
If sodomy were natural, the human species would not exist. The doctor is correct.
The doctor who spoke was a woman.
What is unnatural about a man putting his penis in another man's anus? It is as natural as a polar bear riding a bicycle at the equator.
Homosexuality is an unnatural choice. It is a choice, no quesstion! When a man is born a man, only his arrogance will make him not act like a man.
a woman, not man
Well, he has studied at the foot of a master
She has a PhD in Forensic Medicine....smarter than 99.9999999999999% of the pro-homosexual "journalists" who will cover this story.
**Society decides what is natural and normal.**
Glad you put the "hah" at the end of your post.
God decides what is natural and normal.
There are some of us who believe the Invisible Sky Wizard doesn't really care.
Universal rules were put into place for us to follow or not to our own advantage or detriment.
"Marriage" is whatever everyone agrees it is. That makes it law.
I don't see why lawyers aren't pushing polygamy more. The complications in law would bring in all kinds of new divorce-related business.
God determines all morality...when society turns away from God you get the problems we are experiencing today and getting worse rapidly. The fallacy that man creates morality is what gets us into trouble. Justification is an interesting thing to consider...every human MUST justify their thoughts and behavior...without exception. Even the insane must justify. The reason for this is because God already instilled right and wrong in us...His laws. So, justification is our human attempts to conform to those laws (we do not even have to have an awareness of God for this).
Your "God" is not MY God.
Welcome to America, where we're free to choose.
Thank you, Tom Jefferson.
Heterosexuality is the norm for the animal kingdom. Consider the consequences for that kingdom if the norm were to suddenly shift to homosexual behavior.
It's not normal for a member of ANY species to behave in a manner that would lead to that species going EXTINCT if that behavior was practiced by a large percentage of that species.
"For my thoughts are not your thoughts, neither are your ways my ways," declares the LORD. Isaiah 55 8
But it's a free country.
It is obviously unnatural, pervertedly so. It is also part of the cycle of pedophilia. But, the culture destroying left has intimidated the world into accepting homosexuality as normal, harmless and cute. Bravo to anyone who stands up against all the leftist filth.
Where's Captain Obvious when you need him? Hanging out with Captain Hindsight?
I prefer to think for myself as to what is natural and normal.
One object lesson comes from my Navy son who spend his naval career flying around in P3 aircraft.
He called us one day when he was overseas but he couldn't say where he was. The phone he called from, however, had a number ... and that number told me he was on the ground in Saudi Arabia.
My son told me more later about being there. One event was that his arab hosts invited he and his buddies to go to Friday ceremonies where they were given front row seats. That ceremony turned out to be the standardized religous execution of locals ... and ... bloody-area ... front row seats were for infidels.
What needs to be realized here is that there are religious nuts everywhere.
How would you like to live in that "society"?
He is, there is only one God...anything else is a false idol. You can argue with that till you are blue in the face but you cannot change that reality.
By the way, God gave you the freedom to choose, not Thomas Jefferson...Jefferson was just a man, not a God.
"Heterosexuals don't talk about sex. It's a private matter,"
...in India.
Saw an Indian Dr pin an entire staff to the wall over homosexuality in a patient last month. Took them to task for not treating the mental disorder as well as the physical disorder.
The American Psychiatric Association classified homosexuality as a mental disorder until they changed their minds in 1973.
Were they wrong then, or are they wrong now?
Either way, we see they have no credibility.
...in India.
Thanks. That explains things.
Once the Queer gene is discovered and can be pin pointed, the fetus can be aborted
Evolution makes clear that man and woman evolved to perform two separate sexual functions.
The Bible makes clear that man and women were made by God to perform two separate sexual functions.
Therefore, in either case, there is no logical support for homosexuality. It is an abnormal condition.
While it may be 'natural' to be born with a physical, or let's say a mental defect (like homosexuality), it certainly is not 'normal.'
Homosexuality is not normal.
I've said it before and I'll say it again: LGBT people suffer from a mental disorder. Their LGBT proclamations should serve as a first step toward treatment.
"Universal rules were put into place for us to follow or not to our own advantage or detriment."
Put in place by who?
Our founding fathers derived their concept of individual rights ("Natural Law") from John Locke and the concept that life, liberty and property were granted by the Creator, that man was endowed by the Creator to have these rights, therefore, rights granted by the Creator could not be legitimately taken away by man. Rights granted by man can be taken away by man.
So, absent the Creator, we have no "Natural Rights" and what rights we do have are bestowed by man.
I understand your point, but I agree with his statement.
Meet a homosexual for the first time and within 5-10 minutes, somehow they will bring up the fact they are homosexual.
Homosexuals are all about their sexuality as if it defines the very core of their being. I think what was being said was heterosexuals don't go around talking about their sexuality, whereas homosexuals do.
She's right again.
She's talking from the Indian context.
Yes. We all know that is very likely to happen. We should rely on the views of a psychiatrist from India!
India recently passed or re-affirmed a law against homosexual acts. I don't know the details but basically nothing public, no proselytizing etc. Of course the fags freaked out. It is 100% condemned and loathed in India, has been for thousands of years.
Doesn't matter where she's from.
She's telling the truth.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
This item from Alley Cat Lane Antiques and Collectibles is now in the Shop Backroom
More from Alley Cat Lane Antiques and Collectibles
Goebel M L Hummel Anniversary Plate 'Stormy Weather' 1975
For the Hummel collector, here's the gorgeous porcelain plate with bas relief design of "Stormy Weather.' The plate was issued in 1975 as the first edition of the Anniversary plates. It is hand painted and measures 10.5" in diameter. The condition is excellent, except for one tiny area on the back by the rim where there is a fine light crack which is very difficult to see, feel or even find when you are searching for it. I tried to show it in the photo but as stated it's difficult to see even with the naked eye. It comes with the original box which is in poor condition as shown in the photos. No paperwork. The original price when issued was $100. The trend value according to the Price Guide to Contemporary Collectibles and Limited Editions is listed as $100-150. Price is reduced to take into account the damaged box and slight flaw. Still an absolutely gorgeous piece.
If you were the pending buyer of this item, go to My Account to view, track and check payment for this item.
Alley Cat Lane Antiques and Collectibles
Carolyn Martin, Tallahassee, FL
Great collectibles, friendly service, careful packing and quick shipping. Purrfect!!


text:
The part you requested is no longer available in our stores.Please select a brand or category from the left menu.
Kuryakyn Electronic deer alert, Black - Universal fit on 12-volt motorcycles. We recommend purchasing KUR-4044 Motorcycle Wiring Kit. Kuryakyn P-Clamps make installation a snap.
3-in-1 Headband - (Color:Paisley Navy)(Size:OSFM)
Hyper Optiks Visor Inserts


text:
Baywatch (1989–2001)
Episode List
17 Jan. 2000Liquid Visions
After a rescue of a man who survived after more than 20 minutes underwater, Dawn and Sean are drawn to the strange and spiritual power of the mind over matter theory which she tries to prove the theory of the mind controlling the body after its other functions have shut down to sustain life. Meanwhile, Jessie and Allie tag along to help a lonely Kekoa meet her perfect mate in a so-called training program, which takes a turn when during a boat out with their respective dates, the three have to make a rescue of a capsized sailboat in the water off Wakiki.
31 Jan. 2000Lines in the Sand
Sean has his hands full in dealing with Jenna Avid, the new head of the Oahu North Shore lifeguards, who issues some stern recommendations to the team, which is overshadowed later that day when a group of nudist activists, lead by a certain Leesa Strickler, choose the beach near the Baywatch Hawaii headquarters as their place of protest against the establishment which Sean, Jason, Allie, and Dawn have also deal with the media circus that arrives too. Meanwhile, J.D. and Jessie question where has their love for each other had gone during a long boring day at a deserted...
7 Feb. 2000The Hero
Sean faces a personal conflict where he tries to resist Kekola's flirting advances which leads her, Dawn and Allie to re-examine their own femininity in themselves. Meanwhile, Jason sets his sights on Maxine, a famous actress in town to shoot some scenes for her TV series and who asks Jason to try out in a scene. Also, J.D. faces nothing but ill luck when he tries to find the perfect mate for himself after his breakup with Jessie.
14 Feb. 2000Thunder Tide
Another long day begins with Sean, Jessie, and Kekola trying to save a woman trapped in an air pocket beneath a coral reef and trying to escape from the dangerous sulfur fumes within the cave. After a rescue of three skydivers whose parachutes open late, Dawn find a number of similarities between one named Jerome, and her ex boyfriend Ryan whom she discovers that they are both the same person. Meanwhile, Jason and Allie are assigned to Sandy Beach where he does not know if he can work well at this particular beach after an accident that left a surfer crippled for life...
21 Feb. 2000Breath of Life
Sean sends Jason to the big island of Hawaii to meets with Kulu Puno, an elderly Hawaiian and his beautiful young granddaughter where Jason is given a task of building an old fashion Hawaiian canoe as part of a path he must see to redeem himself from his arrogant, immature nature. Back at Baywatch Hawaii, Dawn tells Sean that she objects to his blossoming relationship with Jenna. But Dawn's suspicions prove correct when during a dinner date out, Jenna tells Sean that she wants to take over the team in order to shut down the training center since she feels that keeping...
13 Mar. 2000Big Island Heat
During a long day when Sean takes Jenna out on a Scarab motorboat when after a rescue of a injured young boy from a offshore reef, Sean reveals a secret to Jenna that could threaten his position when he tells her about his own son, that no one knows about, who drowned years ago which ruined his life and paved his way to becoming a lifeguard. Meanwhile, Allie and Jason take out her helicopter for the day to the big island of Hawaii first to escort a wealthy lady and her young daughter to a resort, then to aid four people trapped on a lava reef where one man goes into a...
24 Apr. 2000Maui Xterra
Jessie tries to overcome her physical condition, and Sean's objections, to compete in a Maui triathlon with Dawn as her personal coach while Allie suspects an agenda behind Dawn's motives to train Jessie. Meanwhile, Jason, with Kekola's help, seeks out a mysterious Hawaiian spirit who inhabits the underwater surf and who lures people to their deaths.
1 May 2000Baywatch O'Hana
Sean tries to keep his blossoming relationship with Jenna a secret to avoid upset and criticism from the rest of the team when he attends a lifeguard conference on Maui to speak about the dangers of drowning where Jenna, Allie, Kekoa, Dawn, and Jason are in attendance. Here Sean's fears and desires are revealed when during a rescue of a group of swimmers trapped in a filtration tube, Jenna is sucked down a shaft and Sean risks everything to save her.
8 May 2000Last Rescue
Mitch helps Jessie try to prevent her World War II veteran grandfather from committing suicide who was a survivor from the USS Utah at Pearl Harbor and who harbors a guilt over surviving when many of his friends didn't on December 7, 1941. Meanwhile, Sean tries to help Kekola's friend, Jemal, a competitive basketball player, to make the University of Honolulu swim team as a potential athlete for the next Olympic swim team. Also, J.D. and Jason have their own hands full in dealing with various bikini clad women in crisis.
15 May 2000The Killing Machine
Mitch is asked by a government agent to investigate a certain Zack Martin, a former Navy SEAL who may be part of an environmental terrorist group called "Green Scorpion" who are planing to blow up an unknown target. Mitch then goes out on a diving boat trip with Zack and his girlfriend Bree Hanford, who in fact is actually the leader of the group whose target in an offshore reef covered with sunken World War II navy ships loaded with unexploded munitions to blow it and the reef up. Meanwhile, Sean thinks Mitch's strange behavior is that he may be in trouble, and after...
2 Oct. 2000Soul Survivor
During the training sessions for new Baywatch Hawaii lifeguards, Sean deals with Jena and other Hawaiian officials who don't see the training center as a profit making enterprise. During a drive, Sean accidentally hits into Zack McEwen, a new recruit and surfer from Michigan who joins the training team while Jason becomes acquainted with Carrie Sharp, one of the rookies from San Diego who finds him irresistible. Meanwhile, Sean and the new lifeguard Leigh Dwyer deal with Cliff, a old nemesis of Sean's who arrives in Oahu for a wave runner race and disrupts the daily ...
9 Oct. 2000A Knife in the Heart
A typical day begins when Kekoa deals with three rescues simultaneously one of which involve a brash and spoiled teenage wave runner who causes accidents in the area in which his equally spoiled and arrogant father threatens to sue the team for not coming to his aid in time. Meanwhile, J.D.'s personal problems in Jessie leaving him and his choices over staying in Hawaii affect his temper in which he begins taking it out on Sean and everyone around him. Also, Zack is still trying to get in on the goods of the rookies while Carrie continues her training and pursing ...
16 Oct. 2000Bad Boyz
Sean has his hands full in dealing with Jena who wants to close down the training center to make room for a group of crooked investors looking to turn the Oahu North Shore into a hotel chain. So, Leigh tries getting Erica, a British entrepreneur to be the Baywatch Hawaii sponsor in order to keep the training center open, but with complications whom she makes advances to Sean. Meanwhile, Carrie thinks that she is not lifeguard material after fear takes over during her first rescue after her reluctance to jump from a hovering helicopter into the water far below.
23 Oct. 2000Dangerous Games
Sean becomes concerned over Leigh's new boyfriend Sam Parks, an airplane pilot who thrives on living dangerously, and whom takes her out on a hand gliding trip headed for disaster. Meanwhile, Kekola's conniving and outgoing cousin, Nani, causes problems for her and J.D. when she brings him over for a family dinner knowing that Kekola's domineering father will disapprove of him, as well as Kekola's lifeguard job, while Nina gets into danger when three drunken college friends of hers try to assault her during a sailing trip the next day.
30 Oct. 2000Stone Cold
Jason becomes smitten with Maya Morgan, a young volleyball player and an old childhood friend of Carrie's and thinks that he's found the girl of his dreams, never imagining that Maya is dying from a heart disorder unless he gets a heart transplant. Meanwhile, Leigh deals with Danny, a sociopath juvenile delinquent and pathological liar who causes trouble around the area whom Sean sees Danny as lifeguard material, while the devious Jenna takes advantage of the tension between Leigh and Sean to try to get Leigh to turn against him.
6 Nov. 2000Broken Promises
After Danny gets into trouble again with the law, Sean gives him a choice of being arrested or joining the training center team. Danny reluctantly joins the rookie team, much to Leigh chagrin who openly admits that she does not trust Danny, while Jenna continues her mind games by trying to recruit Leigh under her wing. Meanwhile, Kekoa has trouble again with her father over her lifeguard career in which she moves out not wanting special treatment from either her father or J.D. Also, Zack and Jason try to court two attractive women who turn out to be con artists when ...
13 Nov. 2000Dream Girl
Jenna intensifies her personal war against Sean by confiscating some of the team's equipment, including a Scarab, and trying to get her boss McKenna, a ruthless and greedy local councilman, to close down the Baywatch Hawaii training center. Things get even worse for Sean when he's forced to suspend Zack from the team after he foolishly disregards orders during a rescue and injures J.D. With J.D. in the hospital, Kekola tries to deal with this turn of events as well and she confides in Leigh about her feelings towards him, while Zack spends the time mopping around the ...
20 Nov. 2000The Cage
Sean deals with Blake, a nefarious "shark tour" provider who dumps chum bait in order to lure dangerous sharks to the area for tourists to see from underwater shark cages causing the beaches to become dangerous with the sharks in the area. Meanwhile, Jason is having problems with Al Raymond, a bumbling tourist who is trying to impress his spiteful young son Noah. Also, J.D. and Kekoa try to keep their blossoming relationship a secret knowing Sean will disapprove of teammates dating.
27 Nov. 2000Ben
Sean struggles with his inner demons after a teenage friend, named Mike, dies during a surfboarding outing which a frustrated Sean patle boards out in the ocean, runs into a rain squall where stranded in the ocean he has visions of the people in his life and of his own long dead son Ben. Meanwhile, Jason, J.D. Leigh and Carrie deal with Zack being on the opposite side of an lifeguard team competition as well as Jenna on their side.
4 Dec. 2000Ties That Bind
Zack becomes devastated when Sean refuses to promote him to a full-time lifeguard due to his brash and reckless attitude after rashly trying to capture a purse snatcher on the beach, in which Sean gives the promotion to Carrie instead. Meanwhile, Zack and Jason befriend Barney Poe and his teenage daughter Liv who harbor a dangerous secret that they are on the run from Barney's ex-wife seeking to reclaim her daughter, and they ask Zack to supply them with a boat in order to get to Maui where disaster strikes before they get there.
11 Dec. 2000Black Widow
Leigh and Sean become entangled in a dangerous position when he suspects an attractive tourist, named Sasha, of murdering her husband, but cannot prove it to anyone. Meanwhile, Jason finds himself in awkward circumstances when Zack brags about their ability to beat Brian in diving and other physical terms over hanging out at their favorite beach place.


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Type: Forum Threads; User: Lwize
Forum:The Car Lounge
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Forum:Golf V & Jetta V


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•September 15, 2011
Health photos
Health photos
Anamatopeya: What exactly do Bernie Sanders supporters expect? Do they really believe that college education is going to be free, and banks are going to be broken up, and republicans are going to vote for a $15 minimum wage and everything is going to be peachy? And is their position that either they get all that or they will destroy Mrs. Clinton and let Trump win? Think about it if you're one of those with this kind of mentality. Reflect on your level of maturity and understanding.


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I've been using WooCommerce on a yootheme template which has been working absolutely fine (disregarding the few CSS styling quirks here and there), apart from the order confirmation/thank you page where no payment instructions are displayed for methods such as BACs, Cheque, Cash etc. The only way the customer can find this information is through email which is less than ideal.
I also want this to appear on the order overview section. Switching to Twenty Eleven fixes this problem, with the 'Checkout' page link magically appearing on the menu. Could this mean this is either a theme or permalink issue?
Has anyone encountered this problem before? How can I go about to fix it?


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Top Definition
A sad, sad little town. Some describe it as where the orchards meet the forests, it don't get more rural than that.
TOM: Dude, you wanna go to Naches?
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PHIL: No thanks, I'm allergic to apples.
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Trending Now
A small town 15 minutes outside of Yakima, filled with the best people alive!!!
nothing can compare to Naches
بواسطة Sexy bitch 17 ديسمبر/كانون الأَوّل 16, 2010
A substitution for any word. Also can just be used to express emotions.
Hey Nach did you nach the nach?
بواسطة Shinnysun مايو/أيار 27, 2006
A nicer way of saying that someone is fat or overweight.
"That guy's a nach!"
"Wow! You're sure nachin' up(getting fat)!"
"Wow! You're sure nachin' up(getting fat)!"
بواسطة Ambyeyes [Megan] يونيو/حَزيران 11, 2006


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This page requires a MaxPreps membership account.
Don't stress... It's free and easy to setup.
The Trotwood-Madison Rams football team won Friday's home conference game against Butler by a score of 27-3.
(October 26, 2012: Trotwood, OH 45426) The Trotwood-Madison Rams defeated the visiting Butler Aviators football squad by a tally of 27-3 in Friday's league bout.


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Bush to Smooth
I shave my full bush away and leave myself smooth
- 5:47
- 1180
- 100%
- 8
I shave my full bush away and leave myself smooth
My climax and big hot load shooting from my hard cock!
My rock hard cock shooting a big load of cum on the table.
Shot a nice load on a dark tray, can see my cum sparkle :)
Watch me shoot another nice big creamy load on the wall and watch it drip down....
About 10 shots of thick creamy cum spurt out of my cock on to the floor.
Nice load shot right on the camera lense (it was a surprise, I guess I was more turned on than I...
Big load in shower stall on the glass door for a great view
Anyone into small dicked sub? cbt? sph? stuff like that? send me a msg for yahoo or...Read Blog >


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Big Ten
Print without images
Monday, December 21, 2009
Big Ten lunch links
By ESPN.com staff
The Big Ten had a better weekend than the NFC North. Ugh.
Former Purdue coaches
Joe Tiller (football) and Gene Keady (basketball) sound off
about the possibility of Big Ten expansion, Mike Carmin writes in The (Lafayette) Journal and Courier.
The Big Ten expansion discussion should
start and end with Notre Dame
, Sean Keeler writes in the Des Moines Register.
weak secondary got even weaker
after cornerback
Donovan Warren's early departure
to the NFL, Mark Snyder writes in the Detroit Free Press.
A good sign for Michigan State fans, as top recruit William Gholston
attended Saturday's basketball game
in East Lansing, Eric Lacy writes in The Detroit News. Also,
Spartans safety/linebacker Brynden Trawick is transferring
, Joe Rexrode writes in the Lansing State Journal.
Oregon athletics director and former football coach
Mike Bellotti could have had the Ohio State job
, Rob Oller writes in The Columbus Dispatch.
Illinois athletic director
Ron Guenther sounds off on all the recent changes
in Champaign, Loren Tate writes in The (Champaign) News-Gazette.
no longer wants to be reminded of its bowl wins drought
, Teddy Greenstein writes in the Chicago Tribune.
Wisconsin defensive tackle
Jordan Kohout has transformed his body
in a year on campus, Tom Mulhern writes in the Wisconsin State Journal.
Missouri's governor wants the state's top university
to consider the Big Ten
Joe Paterno turns 83 today, and
he might have more power at Penn State
than ever before, Cory Giger writes in The Altoona Mirror.


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ANAHEIM, Calif. -- Texas Rangers Josh Hamilton said the right knee tendinitis is still bothering him, so he was off again for Sunday's series finale against the Los Angeles Angels.
Hamilton did pinch hit, however, walking in the Rangers' 4-1 loss.
Rangers officials said Saturday that Hamilton is getting extra recovery time after the slugger left Friday night's game early with knee pain.
Hamilton said he received a cortisone shot on Sunday and can already feel a difference. Manager Ron Washington said he expects Hamilton to be back in the lineup on Tuesday.
"We'll give him these two straight days to rest it and he'll be back in there," Washington said.
He got a shot in May and it helped calm the knee down for a few months. The hope is that this shot will do the same and keep the leading hitter in the majors with a .362 average feeling good through the end of the season and into the postseason.
"It's not really a pain issue. It's not something I can't deal with," Hamilton said. "It just gives out on you at times that it need not to give out on you. If it doesn't work right, it's frustrating. It can't really happen, especially in the situation we're in as far as playing in our division and on this road trip and needing to be able to perform baseball functions."
Hamilton said he talked with Washington during Friday's game about playing in an outfield corner to protect his knee. He started in center, moved to left field in the fifth inning and was taken out in the seventh.
He has played in center 26 times this season.
David Murphy replaced Hamilton in left Saturday. He went 1-for-3 with a walk and scored a run.
Also in the lineup Saturday night were two recent acquisitions made their first starts for the Rangers, first baseman Jorge Cantu and second baseman Cristian Guzman. Cantu went 1-for-4 while Guzman was hitless and struck out twice in four at-bats.
Guzman, whose trade from the Washington Nationals became official Saturday, is batting sixth. Cantu, who came from the Florida Marlins, is hitting seventh.
Richard Durrett covers the Rangers for ESPNDallas.com. You can follow him on Twitter or leave a question for his weekly mailbag.


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text:
Jumbled NETs promote vasculitis
Version of Record online: 27 OCT 2012
DOI: 10.1002/art.34615
Copyright © 2012 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 64, Issue 11, pages 3498–3501, November 2012
Additional Information
How to Cite
Radic, M. and Kaplan, M. J. (2012), Jumbled NETs promote vasculitis. Arthritis & Rheumatism, 64: 3498–3501. doi: 10.1002/art.34615
Publication History
- Issue online: 27 OCT 2012
- Version of Record online: 27 OCT 2012
- Accepted manuscript online: 6 JUL 2012 02:49PM EST
- Manuscript Accepted: 28 JUN 2012
- Manuscript Received: 18 JUN 2012
Funded by
- Lupus Research Institute of New York
- Abstract
- Article
- References
- Cited By
Drug-induced autoimmunity provides a fascinating glimpse of the environment's contribution to the development of anti-self reactivity. After a period of treatment, certain drugs induce, in a subset of individuals, clinical signs that are typically found only in autoimmune disorders. The clinical features of drug-induced autoimmunity are a reminder that genetic predisposition to self reactivity usually needs a trigger from the environment in order to initiate a self-sustaining vicious circle. Notably, the cessation of drug therapy typically brings about the resolution of the autoimmune manifestations. Thus, studies of drug-induced autoimmunity provide an opportunity to learn not only about environmental triggers that lead to a loss of tolerance, but also about how a disruption of a specific stimulus may allow the immune system to return to a previous state of nonautoimmune homeostasis.
Historically, hydralazine, a hypertension medication, was the first to be reported to induce systemic lupus erythematosus (SLE) in up to 24–50% of the patients taking it (1). This medication can also induce symptoms of vasculitis. Other medications, such as procainamide, chlorpromazine, penicillamine, and sulfasalazine, were observed to induce SLE and vasculitis. The discovery of drugs that induce autoimmunity prompted researchers to examine possible mechanisms. Various hypotheses have been proposed, including that the drug structure mimics the autoantigen, that the drug chemically modifies the autoantigen structure, that it inhibits DNA methylation thereby leading to perturbed T cell regulation, that it alters mechanisms of antigen presentation or lymphocyte activation, or that the drug is converted into chemically more reactive compounds in the body. However, thus far the testing of the proposed mechanisms has been difficult, and few conclusions have been put forth to explain how drugs induce autoreactivity (2).
The article by Nakazawa et al in this issue of Arthritis & Rheumatism (3) presents a new twist on drug-mediated induction of autoimmunity. The authors examined the connection between propylthiouracil (PTU), a drug that is commonly prescribed for hyperthyroidism or Graves' disease, and the subsequent development of a form of vasculitis that is associated with the production of autoantibodies to myeloperoxidase (MPO), an enzyme stored in neutrophil granules. The authors explored the role of neutrophil cell death in PTU-induced autoimmunity. It is of interest to view the findings of Nakazawa et al in the context of previous observations on the role of PTU in the induction of vasculitis and other autoimmune manifestations.
PTU is a thionamide drug that, since 1947, has been prescribed to millions of patients with elevated levels of thyroid hormone. Graves' disease is frequently caused by autoantibodies that bind the thyroid-stimulating hormone receptor and lead to the overproduction of thyroid hormone. PTU blocks a key enzyme in the synthesis of T4 from its precursor thyroglobulin. The thyroid gland secretes T4 following its iodination on tyrosine by thyroid peroxidase (TPO). PTU inhibits oxidation of iodide by TPO and therefore effectively limits the production of thyroid hormone. TPO is structurally related to lactoperoxidase and MPO. The similarity between members of this family of proteins is so high that MPO can be used in enzyme studies as a stand-in for TPO (4), and structural similarity between MPO and TPO was exploited to express chimeric molecules and map antibody epitopes on TPO (5). In that light, it is perhaps not surprising that PTU also inhibits the enzymatic reactions of MPO (6).
The side effects of PTU in patients with hyperthyroidism include the production of antibodies to MPO, and some individuals with PTU-induced anti-MPO antibodies progress to exhibit additional symptoms, including cutaneous vasculitis, crescentic glomerulonephritis, and agranulocytosis (7–9). In idiopathic vasculitis, the tight correlation between anti-MPO autoantibodies and disease was previously observed. Small-vessel vasculitis is commonly related to the presence of antineutrophil cytoplasmic antibodies (ANCAs). More specifically, anti-MPO antibodies serve as markers for the diagnosis of microscopic polyangiitis, while anti–proteinase 3 antibodies are considered markers for the diagnosis of granulomatosis with polyangiitis (Wegener's) (10).
Antibodies to MPO are considered to be directly involved in the pathogenesis of vascular inflammation, since mice immunized with MPO develop systemic vasculitis with crescentic glomerulonephritis and pulmonary hemorrhage (11). The symptoms can be transferred from immunized mice to naive animals by transfer of purified anti-MPO IgG. The necessary contribution of neutrophils in this model of ANCA-associated vasculitis (AAV) was shown by the reduced severity of symptoms in mice whose neutrophils were depleted prior to infusion of the pathogenic autoantibodies (12). Incubation of neutrophils with ANCA induces degranulation and reactive oxygen production, thus suggesting how anti-MPO ANCA–induced inflammation could give rise to vasculitis (13). In WKY rats, immunizations with human MPO have been optimized to result in a 100% incidence of crescentic glomerulonephritis and lung hemorrhage (14). It has thus been confirmed that anti-MPO antibodies can, on a susceptible genetic background, lead to the most severe manifestations of systemic vasculitis.
In the context of the prior studies, Nakazawa et al proposed the attractive hypothesis that PTU perturbs neutrophil cell death in such a manner as to induce anti-MPO antibodies and produce symptoms of vasculitis. The results of previous studies had suggested that apoptotic cell death provides access to nuclear autoantigens, and that an immune response to apoptotic cells may lead to systemic autoimmune disease (15, 16). However, the question of whether other forms of cell death provide access to autoantigens has been less thoroughly examined.
A distinct and potentially relevant form of cell death leads to the release of nuclear chromatin from granulocytes (17). The released chromatin is referred to as a neutrophil extracellular trap (NET) because it may serve to immobilize infectious microbes (18). NETs are thought to be an innate response to infections because they organize neutrophil granule components and contribute to the neutrophil's bactericidal functions. The production of NETs occurs as a result of a unique form of cell death called NETosis (17). NETosis appears to depend on the cell's ability to produce reactive oxygen species, including superoxide, and various oxidation products generated by MPO (19). Interestingly, ANCAs induce NETs in vitro, and NETs were detected in kidney biopsy specimens from patients with small-vessel vasculitis (20). Thus, it was reasonable to predict that NETosis could play a role in PTU-induced vasculitis.
Nakazawa et al (3) provide exciting data showing that PTU inhibits full release of NET chromatin and results in a more compact NET scaffold. This is despite the fact that PTU-treated NETs contained normal levels of deiminated histone H3, a histone modification that precedes and is required for NET release (21). The altered morphology of PTU NETs correlated with an increased resistance to nucleolytic degradation; thus, PTU presumably lengthens the NET's half-life in vivo. Furthermore, the authors reported that immunization of WKY rats with NETs formed in the presence of PTU resulted in the production of anti-MPO ANCA and pulmonary hemorrhage. To test whether oral administration of PTU affects the induction of vasculitis in vivo, Nakazawa et al added PTU to the rats' drinking water and induced NETosis by weekly intraperitoneal injections of phorbol myristate acetate, a potent NET agonist. The rats receiving both treatments had more anti-MPO ANCA, greater pulmonary hemorrhage, worse renal function, and a higher incidence of glomerulonephritis than the rats receiving either chemical alone (3).
The immediate contribution of Nakazawa et al includes the testing of a possible mechanism of PTU-induced MPO AAV and the development of a new animal model of this form of vasculitis. Nonetheless, important questions remain to be addressed. Do the anti-MPO antibodies generated by PTU/NET immunizations have the capacity to transfer disease to a naive animal? Is MPO indeed the target of PTU, and is the altered structure of PTU-treated NETs due to the inhibition of MPO activity? Would immunization with PTU–MPO complexes induce anti-MPO autoantibodies, or is the presence of DNAse-resistant NETs important in stimulating the anti-MPO response? The work by Nakazawa et al also raises hopes that we will learn more about environmental contributions to autoimmunity. Do infections or an autoimmune genetic background that leads to exaggerated NETosis contribute to the initial manifestations of MPO AAV? Do other drugs that induce autoimmune manifestations also affect NETosis? It may be important to examine drugs that are known to induce agranulocytosis, since one way to deplete neutrophils is by inducing excessive NETosis. Potential candidates are chlorpromazine, procainamide, hydralazine, and sulfasalazine.
The insights provided by Nakazawa et al also have broader implications. Other studies have suggested that NET-associated autoantigens are important stimuli in autoimmunity, as MPO ANCAs are only one of many autoantibodies directed at NET components. An interesting comparison is provided by antibodies to deiminated histones, a potentially useful marker for neutrophil responses to inflammatory stimuli (22). IgG from patients with Felty's syndrome exhibit a consistent preference for deiminated histones over nondeiminated histones, suggesting that NETs are involved in breaking immune tolerance in this disorder (23). NET components could directly stimulate the immune system, as complexes between chromatin and LL37, a neutrophil granule component that tightly associates with NETs, stimulate activation of plasmacytoid dendritic cells and secretion of type I interferon (24). The presence of autoantibodies to NET components, just like the administration of PTU, may protect NETs against degradation, suggesting that, in autoimmunity, these chromatin matrices persist for a longer time (25). This may be amplified by the tendency of an aberrant subset of neutrophils for enhanced spontaneous NETosis in disorders such as SLE and psoriasis (26, 27), conditions that can be triggered by medications. Aberrant NET formation can potentially promote autoreactivity in other ways, including the enhanced activation of T cells (28). These studies support the concept that NETosis is a relevant source of autoantigens in autoimmunity. This new paradigm holds promise for a better understanding of the pathogenic mechanisms leading to the loss of tolerance and for the discovery of new therapies for various autoimmune diseases.
Drs. Radic and Kaplan drafted the article, revised it critically for important intellectual content, and approved the final version to be published.
- 1Syndrome simulating collagen disease caused by hydralazine (Apresoline). J Am Med Assoc 1954; 154: 670–3., .
- 2Hydralazine may induce autoimmunity by inhibiting extracellular signal–regulated kinase pathway signaling. Arthritis Rheum 2003; 48: 746–56., , , , , , et al.
- 3Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody– associated vasculitis. Arthritis Rheum 2012; 64: 3779–87., , , , , , et al.
- 4Myeloperoxidase-catalyzed iodination and coupling. Arch Biochem Biophys 1992; 296: 239–46., .
- 5Human thyroid peroxidase-myeloperoxidase chimeric molecules: tools for the study of antigen recognition by thyroid peroxidase autoantibodies. Endocrinology 1993; 133: 2496–501., , , .
- 6Mechanism of inactivation of myeloperoxidase by propylthiouracil. Biochem Pharmacol 1990; 39: 1467–71., , , .
- 7Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy. J Pediatr 1970; 76: 54–63., , .
- 8Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 1993; 342: 651–2., , , , , , et al.
- 9Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves' disease. Thyroid 2000; 10: 595–9., , , , , , et al.
- 10Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis. Curr Opin Rheumatol 2010; 22: 43–8., , .
- 11Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002; 110: 955–63., , , , , , et al.
- 12The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 2005; 167: 39–45., , , , , , et al.
- 13Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 1990; 87: 4115–9., , , .
- 14Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. Am J Pathol 2009; 174: 1212–20., , , , , , et al.
- 15Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317–30., , .
- 16Nucleosomes are exposed at the cell surface in apoptosis. J Immunol 2004; 172: 6692–700., , .
- 17Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 2007; 176: 231–41., , , , , , et al.
- 18Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532–5., , , , , , et al.
- 19The impact of various reactive oxygen species on the formation of neutrophil extracellular traps. Mediators Inflamm 2012; 2012: 849136., , , , , .
- 20Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 2009; 15: 623–5., , , , , , et al.
- 21PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med 2010; 207: 1853–62., , , , , .
- 22Histone deimination as a response to inflammatory stimuli in neutrophils. J Immunol 2008; 180: 1895–902., , .
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- 26Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 2011; 187: 538–52., , , , , , et al.
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- 28T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses. J Immunol 2012; 188: 3150–9., , , .


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Wolfenstein 3-D Cheats & Codes
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Published by: Atari Corp. (1984-2003)
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Also known as: Wolfenstein 3D
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Computers in Building: Proceedings of the CAADfutures'99 Conference. Proceedings of the Eighth International Conference on Computer Aided Architectural Design Futures held at Georgia Institute of Technology, Atlanta, Georgia, USA on June 7-8, / Edition 1by Godfried Augenbroe
Pub. Date: 05/31/1999
Publisher: Springer US
Since the establishment of the CAAD Futures Foundation in 1985, CAAD experts from all over the world meet every two years to present and document the state of the art of research in Computer Aided Architectural Design. Together, the series provides a good record of the evolving state of research in this area over the last fourteen years. The Proceedings this year
Since the establishment of the CAAD Futures Foundation in 1985, CAAD experts from all over the world meet every two years to present and document the state of the art of research in Computer Aided Architectural Design. Together, the series provides a good record of the evolving state of research in this area over the last fourteen years. The Proceedings this year is the eighth in the series. The conference held at Georgia Institute of Technology in Atlanta, Georgia, includes twenty-five papers presenting new and exciting results and capabilities in areas such as computer graphics, building modeling, digital sketching and drawing systems, Web-based collaboration and information exchange. An overall reading shows that computers in architecture is still a young field, with many exciting results emerging out of both greater understanding of the human processes and information processing needed to support design and also the continuously expanding capabilities of digital technology.
Product Details
- 9780792385363
- Publisher:
- Springer US
- Publication date:
- 05/31/1999
- Edition description:
- 1999
- Pages:
- 398
- Product dimensions:
- 6.10(w) x 9.25(h) x 0.04(d)
Table of Contents
List of Reviewers. Preface. CAD interfaces to the ARROW manufactured product server; R. Amor, L. Newnham. The future of CAAD: from computer-aided design to computer-aided collaboration; Y.E. Kalay. Exploiting the Internet to improve collaboration between users and design team: The case of the new computer laboratory building at Cambridge University; P. Richens, M. Trinder. Urban texture analysis with image processing techniques; C. Ratti, P. Richens. A Web-centric CAD system for collaborative design; R. McCall. Immersive redlining and annotation of 3-D design models on the Web; T. Jung, et al. How do distributed design organizations act together to create a meaningful design? Towards a process model for design coordination; J. Huang. A performance-inspired building representation for computational design; G. Suter, et al. About objects and approaches: a conceptual view on building models; A. Hendricx, H. Neuckermans. The BAS-CAAD information system for design - principles, implementation, and a design scenario; A. Ekholm, S. Fridqvist. Information sharing in building design; J. Snyder, U. Flemming. Aspects of S2; A. Mahdavi, et al. Interactive 2D constraint-based geometric construction system; B. Medjdoub. Collaborative design with NetDraw; Dongqiu Qian, M.D. Gross. The computer's role in sketch design: A transparent sketching medium; M. Trinder. Making designs come alive: Using physically based modeling techniques in space layout planning; S.C. Arvin, D.H. House. An interpolation/extrapolation process for creative designing; J.S. Gero, V. Kazakov. Feature-based high level design tools: A classification; H.H. Achten, J.P. van Leeuwen. pi-Resolution in design space exploration; A. Burrow, B. Woodbury. Feature-based qualitative modeling of objects; J.S. Gero, J.C. Damski. The front of the stage of Vitruvius' Roman theatre: A new approach of computer aided design that transforms geometric operators to semantic operators; G. De Paoli, M. Bogdan. Experiments on animated visual forms; K. Terzidis. Environmental life cycle assessment in an integrated CAD environment: The epilogue approach; R. Ries, A. Mahdavi. Downstream of design: Web-based facility operations documents; M.J. Clayton, et al. The Piranesi system for interactive rendering; P. Richens.
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- 50 years of art: Lititz Outdoor Fine Art Show set for July 30
- Police departments plan community events
- The 'Great Eastern Wizard' of the Park House hotel
- Manheim woodworker crafts bodies for Martin Guitar
- Siblings homeless after being separated 40 years
- Going, going, gone! Local beer events selling out quickly
- 'American Idiot' at EPAC
- Finally: the Ephrata Brewfest!
- The fallout of 11 MC bomb threats
- Second Friday the 13th
Paul R. White United Zion resident, Fire department member
Paul R. White, formerly of East Petersburg passed away Saturday, April 6, 2013 at the United Zion Retirement Community, Lititz.Born in Lancaster, he was the son of the late Ira M. Sr. and Mary Martin White. He was the loving husband of the late Ruth Ebersole White who died in 2007. Paul worked at the former Hoffman Seed Company, Landisville and Hodecker Celery Farm, Manheim. Earlier in life, he enjoyed farming. He was a member of Erisman Mennonite Church, Manheim. Paul was also a member of Hempfield Fire Department, East Petersburg Fire Department and Fire Police.
Surviving is a daughter: Ann L. White of Lititz; three brothers: Clair White of Lancaster; Clyde White of East Petersburg; and Glen White of Columbia; four sisters: Arlene White of Wyoming; Mary Jane Grube of Lancaster; Doris Deck of Silver Spring; and Janet Bell of Columbia. He was preceded in death by two infant sons; two brothers: Ira White Jr. and Kenneth White and a sister: Dorothy White.
Relatives and friends are respectfully invited to attend his memorial service at Erisman Mennonite Church, 8 South Erisman Road, Manheim April 11, 2013 at 11 a.m. Interment will be private at Masonville Mennonite Cemetery, Washington Boro. Friends may visit with the family at the church on Thursday morning from 10 a.m. until the time of service.
Please omit flowers. Those desiring may send contributions in Paul's memory to United Zion Retirement Community, Caring Fund, 722 Furnace Hills Pike, Lititz, PA 17543. To send the family online condolences, please visit buchfuneral.com.


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We recently spent 9 days at the Four Seasons Hotel in Limassol. I travel extensively for work and was extremely impressed with the level of service we received. The food was amazing from the breakfast, lunch and evening meals in the restaurants. If the hotels ethos is to keep you at the hotel then they have definitely achieved their goals as my family never wanted to leave.
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This is now one of the top 5 hotels that I have stayed at and would recommend the Four Seasons to anyone wanting to stay for business, pleasure or even a conference.
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Created in this Craftsy class
Pattern-Free Quiltmaking taught by Joe Cunningham
Combine spontaneous design with traditional techniques for bold quilts that are all your own. Joe Cunningham shows you how in this lively class.
Other projects made as part of this class:
QuiltingFreeze Tag
QuiltingYou Are in a Maze....
QuiltingFantasy Four Patch for Hank
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Good job! I like the way you used several colors. It is a great "modern" look. You did great.
08/21/2013 Flag
This looks great!
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I looks like paint.. it is so smooth.
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I have scheduled some posts, the first of which should have gone at 6.00am this morning. It didn't so I changed it on the calendar to 10.00am. It still didn't do and checking the post itself still showed 6.00am as scheduled publish time. So I changed it in the post to 11.00am and it still didn't go. I went back to the calendar and it was still showing scheduled for wrong time and draggable.
...just logged in again and has now caught up! Is there anything I should be checking or changing somewhere?