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This Wednesday, November 7 at 5 p.m., restaurateurs Steven Cook and Chef Michael Solomonov will welcome the newest addition to their Philadelphia food empire: Citron and Rose, a glatt kosher restaurant and catering company in Merion on the Main Line.
Joining Cook + Solo in the venture is owner David Magerman, a philanthropist who created the Kohelet Foundation, which supports Jewish day-school education.
In anticipation of the restaurant's opening, check out the Citron and Rose vitals, below.
The Food
As at his award-winning restaurant Zahav, 2011 James Beard winner Chef Solomonov will be bringing traditional kosher Jewish cuisine to new heights.
Highlights include new twists on old kosher standbys: Chopped Liver with sour cherry, chocolate and pumpernickel; Mushroom Knish with smoked kasha, tsimmes and carrot-mustard; Salmon Gravlax with everything bagel spice, walnuts and radish; Roast Chicken, featuring honey-paprika glaze, potatoes and arugula; and Pecan Praline Challah French Toast with non-dairy coffee ice cream, fried pecans and maple syrup.
Appetizer prices range from $9 to $12; Entrée prices range from $14 to $28; Desserts are $9.
The Drinks
To complement the food, the team has created a menu of kosher cocktails, including: The Cosmonaut, vodka with beet juice syrup and fresh grapefruit juice; The Lower East Side, gin with cucumber and dill; and Reb Roy, a twist on a classic Rob Roy with scotch and Manischewitz. The restaurant will also feature a variety of kosher wines, craft beers and scotches.
The Vibe
Just like at Zahav and Federal Donuts, Citron and Rose's central open kitchen will offer diners a close-up look at the culinary action. The restaurant also has a bar and chef's counter along with an airy main dining room with comfortable banquette seating and natural wood decor.
A 15-seat private dining room located behind the main dining area is perfect for intimate gatherings. And, weather permitting, Citron and Rose will open its outdoor seating.
Kosher Certification
The restaurant will be under the kosher supervision of Community Kashrus of Greater Philadelphia. Citron and Rose will follow the every tenet of kosher cooking, including being overseen from open to close daily by a mashgiach and not serving on Fridays and Saturdays, as work is forbidden between sunsets on Shabbat.
The venture will also include a full-service catering company for on- and off-site events.
Citron and Rose will be open for dinner Sunday through Thursday. To schedule an appointment with Citron and Rose Catering, email firstname.lastname@example.com.
You can already make reservations online!
Citron and Rose — Opening November 7!
368-370 Montgomery Avenue, Merion
Uwishunu has caught a case of Oscar Fever. With all the buzz around Silver Linings Playbook and its eight oscar nominations this...
The post Roundup: Our Top Picks For The Best Old-School Diners In Philadelphia appeared first on Uwishunu - Philadelphia Blog About Things to Do, Events, Restaurants, Food, Nightlife and More.
Teuscher Chocolates, whose Philly outpost is one of only ten in the U.S., has been declared the Best Chocolate in the World...
The post Teuscher Chocolates Of Switzerland Declared Best Chocolate In The World By National Geographic appeared first on Uwishunu - Philadelphia Blog About Things to Do, Events, Restaurants, Food, Nightlife and More.
There's a chill in the air, which means that the holidays are upon us. That, in turn, means that it's time to...
The post Greensgrow Farms To Host Its Annual Holiday Bazaar, December 8-9 And 15-16 appeared first on Uwishunu - Philadelphia Blog About Things to Do, Events, Restaurants, Food, Nightlife and More.
Thanksgiving dinner wouldn't be the same without those savory, soulful sides that we crave every year. And, our Thanksgiving Throwdown wouldn't be authentic without...
The post Thanksgiving Thursday Throwdown: Soulful Sides appeared first on Uwishunu - Philadelphia Blog About Things to Do, Events, Restaurants, Food, Nightlife and More.


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Kent Moors is an expert on oil and natural gas policy, and a professor in the Graduate Center for Social and Public Policy at Duquesne University. He has been an advisor on oil and related policy to the U.S., Russian, Kazakh, Iraqi, Kurdish and Bahamian governments. Moors's views echo mainstream Democratic thinking on international oil policy, and would likely be reflected in an Obama administration. I recently asked him six questions about the declining fortunes of major oil producers and how the likely impact on American policy. This interview was edited for length and clarity.
1. What sort of shape is the Saudi economy in?
The Saudis never provide documented information on their economy, their oil reserves or revenues, but they clearly have serious problems. They make significant proceeds from exporting oil but they import everything else. The price they pay is dependent on exchange rates, given that their sales are denominated in U.S. dollars. As the dollar goes down, Saudi purchasing power goes down with it — declining 47 percent over the last three years. Meanwhile, their domestic expenditures are increasing significantly. They have a large dependent population and the government has committed itself to providing most services, many free of charge. They have no taxation, but no representation either. There are a huge percentage of unemployed people and half the population is under the age of 26. All the demographics tend towards huge government expenditures.
About 18 months ago, the Saudis started moving their dollar denominated investments out of U.S. sovereign bonds and into Collateralized Debt Obligations, Collateralized Mortgage Obligations, and Structured Investment Vehicles. They did that to increase their return on investment because of their budget squeeze, but they invested themselves right into the credit crunch. They own a lot of paper based on mortgages and other sorts of credit bridges, the values of which have plummeted.
2. What sort of signs are there that the Saudis have money problems?
The Saudis for the first time in years have been quietly going out to European banks for syndicated loans. These are private bank placements, which means you won't see them easily advertised or published, but it means the amount of Saudi interest payments for debt will go up. They use oil still in the ground as collateral on the loans. That is not an unusual practice, but it does create problems when the expected selling price of crude is declining. The fact that they are moving to generate lines of credit at all shows there is a serious problem. There is also anecdotal evidence that the government is concerned about the budget deficit. Riyadh is attempting to force Saudis to take positions that used to be held by foreign workers and requiring Saudi youth who are getting free education to work part time in exchange.
3. What long-term impact does this have on the international oil market?
Traditionally Saudi Arabia has been a restraining influence on increasing prices or cutting production within OPEC. They usually see higher prices as creating two problems: they lead to lower demand, thereby depressing sales, and encourage interest in the United States in developing alternative fuels. So the Saudis have been on one side of the issue while Iran, Venezuela and Algeria have been on the other urging production cuts. However, twice recently the Saudis have agreed to production cuts — 530,000 barrels per day in September and 1.5 million barrels per day last Friday at OPEC's emergency meeting. Their reluctance to cutting production is declining considerably for the reason that they are facing the same budget crisis as other OPEC producers when market prices approach $60 a barrel.
4. Why should Americans care that Saudi Arabia has fallen on hard times?
If the situation continues for any time it will lead to political instability in Saudi Arabia. You may not like the fact that the United States is aligned with an undemocratic, monarchal regime, but there's a blatant security concern. Saudi Arabia is the only country in the world where there's significant excess crude oil supply. They can put an additional one or two million barrels of oil on the market in a matter of hours. No one else can do that, and that gives them immense strategic value. If Saudi Arabia destabilizes, it also undercuts the last 35 years of American foreign policy in the region.
5. Are other oil energy producing countries in the same situation?
There's a real crisis brewing In Venezuela. Even Mr. Chavez has indicated concerns about rising expenses and lower revenues. Budgetary difficulties are already surfacing in Caracas. Along with Iran, Venezuela is arguing for bigger production cuts. While Russia is not a member of OPEC and is unlikely to become one, it has nonetheless showed up with high-level delegations at each of the last three OPEC meetings. Moscow may be considering closer coordination with OPEC. This is at least partly a reaction to Western criticism over the recent events in Georgia. Yet it also results from Russian budgetary difficulties emerging. Russian budget balancing and surpluses have been the result of oil export revenues. The budget was calculated moving forward with oil at $70 per barrel. That was considered quite conservative in July when the price was in excess of $147, but when oil went below $70, the Russians began having deficit concerns. The drop off in oil revenues and the credit crunch have been responsible for huge drops in the Moscow stock market.
6. Again, why should Americans care about Russia or Iran or Venezuela?
These are no longer local problems. Whether one likes it or not, the global oil market is now integrated. Problems in these countries have an adverse impact on the amount of oil going into the market and that impacts us. Those who argue for American self–sufficiency, that we can somehow produce the energy we need here in the U.S., don't understand the nature of the oil market. You can't put up walls and talk about Fortress America, it doesn't work. You have to learn to work with people you don't like, that's an important rule of international diplomacy. In my judgment, we have about 30 years left of a sustainable crude oil based economy. We need to generate genuine alternative energy prospects but still require adequate supply of crude oil at affordable prices to cover us during the next several decades.
More from Ken Silverstein:
Commentary — November 17, 2015, 6:41 pm
The Clintons' so-called charitable enterprise has served as a vehicle to launder money and to enrich family friends.
From the November 2013 issue
Perspective — October 23, 2013, 8:00 am
How pro-oil Louisiana politicians have shaped American environmental policy
In Havana, the past year has been marked by a parade of bold-faced names from the north — John Kerry reopening the United States Embassy; Andrew Cuomo bringing a delegation of American business leaders; celebrities ranging from Joe Torre, traveling on behalf of Major League Baseball to oversee an exhibition game between the Tampa Bay Rays and the Cuban national team, to Jimmy Buffett, said to be considering opening one of his Margaritaville restaurants there. All this culminated with a three-day trip in March by Barack Obama, the first American president to visit Cuba since Calvin Coolidge in 1928. But to those who know the city well, perhaps nothing said as much about the transformation of political relations between the United States and Cuba that began in December 2014 as a concert in the Tribuna Antiimperialista.
Estimated temperature of Hell, according to two Spanish physicists ' interpretation of the Bible:
Department of Applied Physics, University of Santiago (Santiago, Spain)
The ecosystems around Chernobyl, Ukraine, are now healthier than they were before the nuclear disaster, though radiation levels are still too high for human habitation.
A TSA agent in Seattle was arrested for taking up-skirt photos of women in the airport, a Maryland police officer was arrested for taking up-skirt photos of an off-duty colleague, and the Georgia Court of Appeals ruled that taking up-skirt photos is legal in the state.
Subscribe to the Weekly Review newsletter. Don't worry, we won't sell your email address!
"Matt was happy enough to sustain himself on the detritus of a world he saw as careening toward self-destruction, and equally happy to scam a government he despised. 'I'm glad everyone's so wasteful,' he told me. 'It supports my lifestyle.'"

subset: commoncrawl


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what do you plan on getting (or giving) for this upcoming holiday season?
I plan on receiving a tank through means of magic.
Money or clothes would be nice
Kill of Duty – Black Cops 2
Dunno about what I want, seen as I have mostly everything I want for the moment. So I guess money is always nice.
I'm planning on giving some games to friends though.
I really don't want anything, especially not from parents; they never buyt themselves anything so i feel sorry.
absolutely nothing
I plan on getting Resident Evil 6 & Assassin's Creed III & a complete set of copic markers & speed pens
I have no idea what I want, maybe complete my PC setup with some Speakers, and a not so crappy keyboard/mouse. That's for boxing day though. I plan on giving lots of chocolate, lots of it…
A new hat.
Respect for a day.
I've been looking to get new camcorder and a bike, so those would be nice.
And I'll be giving Steam gift cards to friends.
Respect for a day.
I can type this without having this removed only on my main.
Some new headphones would be nice.
World domination.
im not gonna get anything for christmas.
Originally posted by qwerber:I really don't want anything, especially not from parents; they never buyt themselves anything so i feel sorry.
Getting: Cod BO2
Giving: A controller to a friend.
Not getting or giving anything :/
Fat Cry 3, ACIII, a headset and some clothes
Computer parts for the computer I'm building.
The new Samsung Chromebook.Giving something to come to mind later
Originally posted by Casper_D:World domination.
That could work too.
bottle of whiskey
A better computer.
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text: Genco Shipping & Trading Limited ( GNK) lost 1.8% to $14.20 on Monday. The New York-based drybulk shipper filed a registration with the Securities and Exchange Commission to sell up to $500 million of debt securities, common stock, preferred stock, rights, warrants, units, depositary shares, purchase contracts, or any combination thereof on a timely basis. Analysts from Dahlman Rose reiterated a buy rating on the stock in November, reducing their price target by $7 to $23. Genko transports iron ore, coal, grain, steel products and other drybulk cargoes along worldwide shipping routes. Eagle Bulk Shipping ( EGLE) was among the select few in the drybulk shipping sector to enjoy share price gains in Monday's trading session. The stock added 0.6% to close at $4.92. Eagle Bulk Shipping recently posted a 75% jump in third quarter revenue, thanks to higher demand for grain and other bulk shipping cargo. The company said rising demand for coal, particularly in China, should extend the upward trend. "Strong demand for minor bulks and grain contributed to relative outperformance. This trend should continue as we close the year, as the demand picture for coal, grains and minor bulk cargoes should remain strong in the medium and long term," the firm said. Finally, Excel Maritime Carriers ( EXM) shares lost 1.2% to close at $5.58 on Monday. The shipper said last week it entered into a new time charter agreement for seven of its Kamsarmax vessels to first class charterers. "We are pleased to have announced these seven vessel fixtures which significantly increase the visibility of our cash flow generation through a time charter coverage of 45% for 2011," said CFO Pavlos Kanellopoulos. "These charters also allow us to monetize 100% of the upside in market rates through the index-linked element, while at the same time always provide profitable rates securing our cash flow breakeven levels." -- Written by Miriam Marcus Reimer in New York. >To contact the writer of this article, click here: Miriam Reimer. >To follow the writer on Twitter, go to http://twitter.com/miriamsmarket. >To submit a news tip, send an email to: email@example.com. READERS ALSO LIKE: >> 10 Top Dividend Stocks for 2011 >> REIT Earnings: Behind the Numbers >> 18 Overbought Stocks to Sell Now >>See our new stock quote page. Get more stock ideas and investing advice on our sister site, Stockpickr.com. Prev 4 of 5 Next


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Memorial Day holiday car traffic coming into Atlantic City increased by 3 percent over a year ago, bucking a trend so far this year of declining Atlantic City Expressway traffic to the resort.
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I know the question of how to update multiple tables in SQL has been asked before and the common answer seems to be do them separately in a transaction.
However, the 2 columns I need to update have a foreign key so cannot be updated separately.
Table1.a is a foreign key to Table2.a
One of the entries in the tables is wrong, e.g. both columns are 'xxx' and should be 'yyy'
How do I update Table1.a and Table2.a to be 'yyy'?
I know I could temp remove the key and replace but surely there's another way.


text:
Proton Radiotherapy: Practice and Promise
This article has been archived.
Please use for reference only.
Please use for reference only.
Abramson Cancer Center of the University of Pennsylvania
Last Modified: September 30, 2008
Podcast of the "Proton Radiotherapy: Practice and Promise" from the 2008 American Society for Therapeutic Radiology And Oncology conference. International cancer experts give you an exclusive opportunity to learn and share the information on the most recent developments in Proton Therapy. Tune in now to experience the collected knowledge.
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- Welcome and Overview Rationale for Proton Therapy
Thomas F. DeLaney, MD
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Nancy P. Mendenhall, MD
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- The Greatest Margin of Benefit: Pediatrics and Our Ethical Obligation
Torunn I. Yock, MD, MCH
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- Proton Radiosurgery, Pencil Beam Scanning and Intensity Modulation Proton Therapy
Hanne M. Kooy, PhD
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If Lexus is going to stay competitive, it needs to turbocharge sooner rather than later.
Lexus Turbo Engine
- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
- Infiniti dealers ranked best, Tesla worst
- Compare Volvo XC90 and Lincoln MKX


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TriLUG has received generous support from the following organizations and individuals. The sponsors are listed in alphabetical order within each sponsorship category, and the donation made by each sponsor is noted.
TriLUG Sponsorship levels are as follows:
Sponsorship information
Please contact the Steering Committee if you are interested in sponsoring TriLUG.
Platinum Sponsors
Server co-location generously provided by DASH Systems.
Gold Sponsors
Caktus Group located in Durham, NC provides the meeting space for TriLUG Hack Nights, at Caktus' Tech Space. Thank you, Caktus!
The OpenNMS Group has given a generous donation to help reboot TriLUG starting in September 2009. They are the corporate sponsor of the OpenNMS Project, and are the go-to people if you need help running OpenNMS, an Enterprise-grade Network Management tool. We appreciate their support!
Silver Sponsors
O'Reilly and Associates have agreed to give TriLUG members 20% off of all O'Reilly and Associates books purchased at their website or through their phone number, 1-800-998-9938. See a Steering Committee member for details. O'Reilly also generously donates multiple titles to the TriLUG library, and giveaway books for our meetings.
Bronze Sponsors
All Things Open is a conference exploring open source, open tech, and the open Web in the enterprise. All Things Open 2015 is October 19th & 20th in the Raleigh Convention Center.
Intrex Computers, is your 'one stop shop' for all your computing needs including parts, custom systems, repairs, networking & Internet services. Show your membership card at any of the 9 Intrex stores & get discount pricing on all their products. In addition, Intrex.net (the Internet services division) provides local dedicated Internet services, DSL services, and nation-wide Dial Up access, as well as Web, DNS, and Mail hosting, and other e-commerce related Internet services. Intrex provides discounts for TriLUG members.


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Puma concolor
Common Names
Mountain lion, Puma, Florida panther
Wt. 90-200 lb (40-90 kg); Shoulder Ht. 24"-30" (60-76 kg); Length including tail 60"-108" (150-270 kg). The cougar is the second largest cat in the Western Hemisphere (the jaguar is the largest). It has long legs, large feet, a comparatively long neck, and a small broad head. Its ears are small and rounded. The cougar is yellowish to tawny with a white-buff color underside. Color can vary seasonally from tawny to gray. The black cougar is refered to as a panther in Florida and South America. The cougar cannot roar, but can purr and make a screaming or snarling sound. The cougar is solitary and hunts primarily at night. The female is about 40 percent smaller than the male and 1' (30 cm) shorter.
The cougar is a very adaptable cat. It is generally found in mountainous areas but is adaptable to hilly, semi-arid terrains, including lowlands, forests, swamps, grasslands and dry bush. It requires adequate cover and prey.
Western North America from British Columbia and southern Alberta south through the western United States from the Rockies to the Pacific Ocean. Its range continues throughout Mexico, Central America and South America. There are isolated pockets of cougars in the southeastern United States.
Material from GreatLodge.com.
To purchase hunting and fishing licenses online
visit the GreatLodge License Store.


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- 17 1/2 x 13 3/4 x 2 1/2" h. 8 lbs.
- Plug Turntable into existing speaker system (no speakers on Turntable).


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Check out how the song "Glorious Day" by Casting Crowns has caught my attention and also impacted listeners' lives.
Now Playing: Famous One
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On-Air: Morgan Wood
Thanks for listening to the Scott and Kelli Show! You can listen online weekdays from 5-9pm Eastern at www.klove.com/listen.
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Genomic medicine research requires substantial time and resources to obtain phenotype data. The electronic health record offers potential efficiencies in addressing these temporal and economic challenges, but few studies have explored the feasibility of using such data for genetics research. The main objective of this study was to determine the association of two genetic variants located on chromosome 9p21 conferring susceptibility to coronary heart disease and type 2 diabetes with a variety of clinical phenotypes derived from the electronic health record in a population of morbidly obese patients. Data on more than 100 clinical measures including diagnoses, laboratory values, and medications were extracted from the electronic health records of a total of 709 morbidly obese (body mass index (BMI) ≥ 40 kg/m2) patients. Two common single nucleotide polymorphisms located at chromosome 9p21 recently linked to coronary heart disease and type 2 diabetes (McPherson et al. Science 316:1488–1491, 2007; Saxena et al. Science 316:1331–1336, 2007; Scott et al. Science 316:1341-1345, 2007) were genotyped to assess statistical association with clinical phenotypes. Neither the type 2 diabetes variant nor the coronary heart disease variant was related to any expected clinical phenotype, although high-risk type 2 diabetes/coronary heart disease compound genotypes were associated with several coronary heart disease phenotypes. Electronic health records may be efficient sources of data for validation studies of genetic associations.
Genomic medicine research requires substantial resources and time to assemble study populations, collect phenotypic data and biological samples, and to address specific research questions (Service et al. 2003). Moreover, the need for large sample sizes (Eberle et al. 2007) and increasingly precise definition of clinical phenotypes (Cupples et al. 2007) to study complex disorders, such as coronary heart disease (CHD) and type 2 diabetes (T2D), exacerbates demands on increasingly scarce research resources. Use of electronic health record (EHR) data on patient populations seeking care in large integrated delivery systems offers one potential solution to mitigate these challenges (Gerhard et al. in press).
Integrated delivery systems with EHRs offer several significant advantages over traditional approaches to genomic medicine research by simplifying logistics, reducing time lines, and reducing the overall costs through efficient data acquisition (Powell and Buchan 2005). Large numbers of patients can be readily identified and phenotyped using the EHR. Clinical infrastructure can be used to recruit patients, acquire biological samples (e.g., blood), and obtain supplemental data. However, few previous studies in genomic medicine research have used EHR data.
We examined the effectiveness of this model using comprehensive EHR data and biological samples on patients from the Geisinger Clinic Center for Nutrition and Weight Management. We performed a validation study on T2D and CHD genetic variants with a specific focus on patients with morbid obesity (BMI ≥ 40 kg/m2; Flegal et al. 2002). Few genetic studies of obesity-related disorders, such as T2D and CHD, have been conducted with morbidly obese populations (Koumanis et al. 2002). A large clinical database was constructed using data extracted from the EHR and evaluated through analysis of expected clinical associations. Two single nucleotide polymorphisms (SNPs) located in the same region of chromosome 9p21 which has previously been associated with T2D (Saxena et al. 2007; Scott et al. 2007; Zeggini et al. 2007) and CHD (Helgadottir et al. 2007; Larson et al. 2007; McPherson et al. 2007; O'Donnell et al. 2007; Samani et al. 2007) in genome wide association studies, were genotyped and associations with clinical variables determined. The resources and timeline required for these studies were considerably less than would have been required by traditional approaches.
The Center is an integrated practice model for weight management that seamlessly incorporates research as core to the practice. All patients who were enrolled in the Bariatric Surgery Program were recruited into a clinical research program in obesity (Still et al. 2007). Patients undergo a pre-operative assessment and preparation period during which a comprehensive set of clinical and laboratory measures were obtained along with blood samples for serum and DNA isolation. The Institutional Review Board of the Geisinger Clinic approved the research protocol and all participants provided written informed consent.
Patients from the Geisinger Clinic Center for Nutrition and Weight Management's Bariatric Surgery program were recruited between October 2004 and August 2007. A comprehensive medical history and physical examination was performed during the initial visit. Standard of care laboratory tests were obtained pre-operatively, most approximately three weeks prior to surgery.
EDTA anti-coagulated blood samples for DNA isolation were obtained for the study as part of a clinical blood draw. For a small number of patients, blood was not obtained. DNA was then isolated from preserved liver tissue that was obtained from an intra-operative liver biopsy performed as standard of care for the bariatric surgery.
Geisinger Health System is an integrated delivery system with a significant presence in central and northeastern Pennsylvania. Installation of an EHR (EpicCare) began in 1996 in the current 40 community practice clinics and in specialty clinics in two hospitals and was completed (i.e., completely paperless operations) by 2001. The EHR is used for a variety of practice-based tasks including viewing test results, clinical messaging, dictation authorization, and order entry. Essentially all clinical notes are recorded in the EHR along with clinical measures, demographics, orders, diagnoses (based upon the International Classification of Diseases, Clinical Modification or ICD-9 codes), and data from other sources, including digital imaging and lab measures.
Data were extracted from the EpicCare EHR (Verona, WI) using imbedded routines (known as Clarity), provided by the software vendor. Clarity tables can be manipulated using standard queries in SQL (standardized query language) applications. The Clarity tables containing the specific elements in the data dictionary for a particular domain (e.g., physical measurements, or lab measure) were identified, and those fields were extracted into a text file. Typically, all instances of an element were extracted (e.g., all lab results for a specific analyte). The extracted file was read into SAS/STAT software (SAS Institute Inc., Cary, NC).
Specific data elements from the EHR, summarized in Table 1, were selected because of their potential relevance to obesity and related complications, and their relative frequency among the morbidly obese population. For example, the co-morbidities (n = 25) and current medication subclasses (n = 67) extracted were found in at least 2% of the cohort at the initial visit; data elements not present in at least 2% of the cohort were omitted from the study database. The aggregate data obtained from the EHR were queried to extract those specific values (Table 1 variables) that were used to populate the study database. The resulting data file was merged with genotype data using a medical record number.
DNA was extracted from 0.35 ml of EDTA anti-coagulated whole blood using the Qiagen MagAttract DNA Blood Midi M48 Kit and Qiagen BioRobot M48 Workstation (Qiagen, Valencia, CA) according the manufacturer's directions. The final elution volume was 200 μl. For a small number of patients, blood was not available so DNA was extracted from fixed liver tissue. Liver was first treated with proteinase K (1 μg/μl) in 350 μl Qiagen Tissue Lysis Buffer and incubated at 55°C overnight. Following digestion, samples were loaded to Qiagen BioRobot M48 Workstation and extracted for DNA as described above for blood samples. Quantification of DNA extracted was performed using a NanoDrop ND-1000 spectrophotometer (NanoDrop Technologies, Wilmington, DE).
Single nucleotide polymorphism (SNP) genotyping was performed on an Applied Biosystems 7500 real-time PCR System (Applied Biosystems, Foster City, CA). Assay reagents for each SNP were obtained from Applied Biosystems (rs10811661, Assay ID: C_31288917_10; rs2383206, Assay ID: C_1754669_10). DNA was genotyped according to the manufacturer's protocol. Briefly, the reaction components for each genotyping reaction were as follows: 10 ng of DNA, 5 μl of TaqMan Genotyping Master Mix (Applied Biosystems, Foster City, CA), 0.25 μl of assay mix (40×), and water up to a total volume of 10 μl. The thermocycler conditions were as follows: 50°C for 2 min, 95°C for 10 min, and 40 cycles of 95°C for 15 s and 60°C for 60 s. The reaction was then analyzed by Applied Biosystems Sequence Detection Software.
The HelixTree (Golden Helix, MT, USA) software package was used to analyze relationship of clinical variables using split-prediction methodology to either partition the data into subgroups or perform logistic regression on a predictor variable. For a binomial predictor (e.g., diagnosis code), all the observations with "0" as the predictor variable (i.e., lacking a diagnosis) are placed in one group, and all of the observations with a "1" as the predictor variable (i.e., carrying the diagnosis) are placed in a second group. A two-sample t-test is used to determine the probability that the two groups have the same mean. For a continuous-ordinal predictor (e.g., numeric lab value), observations are segmented into k subgroups, each with a different mean. The k − 1 cut-points that optimally split the data in a maximum likelihood sense are reduced by minimizing the sum of squared deviations of the subgroup means from the observations. An F-test was used to generate a raw P-value. An adjusted P-value (aP) was calculated by curve-fitting thousands of simulations. A Bonferroni corrected P-value (bP) was also calculated. A conservative threshold of a bP-value of <0.05 was used for all analyses. HelixTree was also used to determine differences in genotype and allele frequencies, estimate deviation from Hardy–Weinberg equilibrium, and to examine the association of SNPs with database variables. Graphical representation of data was performed using the KaleidaGraph software application (Syngergy Sofware, PA).
More than 100 clinical variables (Table 1) were extracted from the EHR on a total of 824 patients who were consented as part of a bariatric surgery clinical research program on the genetics of obesity and related co-morbidities. Data in the EHR was obtained from a comprehensive history and physical examination performed on the initial visit, with laboratory measurements obtained within one month prior to surgery.
To define a population of morbidly obese patients for study, 49 patients (5.9%) whose body mass index (BMI) was <40, as well as 16 patients (1.9%) whose height and/or weight data were missing, were excluded from the analysis leaving 759 patients. Genotyping was then performed on available DNA from 709 of these patients. Gender, age, race, diagnoses, and medication use were obtained from the EHR on all patients. Values for laboratory measurements were obtained on at least 98% of patients for glomerular filtration rate, glucose, bun, sodium, potassium, chloride, CO2, calcium, and creatinine; on at least 97% of patients for white blood cell count (wbc), red blood cell count (rbc), hemoglobin (hgb), hematocrit (hct), mean cell volume (mcv), mean cell hemoglobin (mch), mean cell hemoglobin concentration (mchc), and red cell distribution width (rdw); on at least 96% of patients for triglycerides, cholesterol, high density lipoprotein cholesterol (hdl), alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase, total bilirubin, and thyroid stimulating hormone (tsh); and on at least 94% of patients for low density lipoprotein cholesterol (ldl calculated), insulin, and hemoglobin A1c. Values were obtained on lower percentages of patients for iron (81%), iron binding capacity (81%), ferritin (81%), platelet count (86%), mean platelet volume (86%) albumin (33%), and total protein (33%). An "iron panel" (iron, iron binding capacity, and ferritin) was added to the clinical protocol after recruitment had begun, which accounts for the lower percentage of patients for those values. A platelet count and mean platelet volume were not reported if a hemoglobin and hematocrit was ordered rather than a complete blood count, which likely accounts for the lower percentage for these patients. Total protein and albumin were ordered only if nutritional status was deemed clinically necessary to evaluate.
The cohort consisted of 709 patients with BMI measurements of 40 or greater with a 97.5% self reported/clinically verified Caucasian ethnicity. Other demographic and relevant clinical data are shown in Table 2.
The database was used to determine whether expected relationships could be found with diabetes (i.e., ICD-9 code 250), defined as a binary variable for both split prediction analysis and regression analysis using the Golden Helix statistical software package. Of the more than 150 variables examined, the diagnosis of diabetes was associated with 35 following Bonferroni correction (bP < 0.05). The top ten statistically related measures to ICD-9 code 250 in the database are shown in Table 3 (3 variables represented by both split prediction and regression analyses). All can be directly related to diabetes. Pre-operative hemoglobin A1C was the most highly correlated (by regression) followed by the diabetes medication biguanides, hemoglobin A1c (split prediction), and insulin. The use of the statin class of lipid lowering drugs was also related, as was age (by both split prediction and regression). All of the relationships are expected based upon the clinical findings in diabetes.
A similar analysis was completed for CHD (i.e., defined as ICD-9 code 414 by clinical staff) as a dependent variable (Table 4). A total of 13 of the database variables were found to be statistically significant following Bonferroni correction (bP < 0.05). CHD medications including nitrates, beta blockers, platelet aggregation inhibitors, aspirin, statins and fibric acid derivatives, age (regression and split prediction), and gender were all statistically related, as was the diagnosis of hypercholesterolemia.
A total of 709 patient DNA samples were genotyped for the chromosome 9p21 T2D SNP (r10811661) and CHD SNP (rs2383206) SNP variants (Table 5). Patients were defined as carriers of the "C" and/or "T" DNA sequences at the T2D SNP and the "G" and/or "A" DNA sequences at the CHD SNP. The T2D "T" SNP and the CHD "G" SNP are considered the high risk SNPs. The frequencies of the minor alleles of the T2D SNP and the CHD SNP (0.49 vs. 0.48) reported for control populations (McPherson et al.2007; Saxena et al. 2007) are in good agreement with the results here (0.17 vs. 0.17 for T2D and 0.49 vs. 0.48 for CHD).
To determine whether the population was genetically skewed through inbreeding or strong founder effects, a statistical test for Hardy–Weinberg equilibrium was performed. Both SNPs were found to be well within Hardy–Weinberg equilibrium (T2D P > 0.19; CHD P > 0.81). The frequency of the SNP alleles is thus consistent with an outbred mixed Caucasian/European population.
Because the SNPs are located within 20,000 bases of each other on chromosome 9, the extent of linkage disequilibrium between them was determined. No significant linkage disequilibrium was observed (LD Correlation R = 0.034), consistent with their presence in two distinct two haplotype blocks.
The diploid SNP sequences or genotypes (i.e., T2D "CC", "CT", and "TT"; CHD "AA", "AG", and "GG"), of each patient for each gene were also analyzed (Table 6). The T2D homozygous high risk "TT" genotype was present in ~70% of the population and the CHD homozygous high risk "GG" genotype was present in ~27%, consistent with previous studies. The T2D heterozygous "CT" and the CHD heterozygous "AG" genotypes were present at ~27% and ~50%, respectively. The low risk T2D genotype "CC" was present in ~3.5% of the population and the low risk CHD genotype "GG" was present in ~24%.
The relationship of the T2D and CHD SNP genotypes to the approximate 100 clinical variables obtained from the EHR was analyzed using the HelixTree Genetics Analysis Software. The initial analysis was performed using the individual T2D and CHD SNP genotypes (i.e., T2D "CC", "CT", and "TT"; CHD "AA", "AG", and "GG"). For T2D SNP rs10811661, two variables were found to be significantly different (bP < 0.05); the percentage of patients with the diagnoses of polycystic ovary syndrome (PCOS) and the diagnosis of hypertension (HTN). Interestingly, no patients with the CC genotype were diagnosed with PCOS and, correspondingly, a lower percentage had the diagnosis of HTN (Fig. 1). The mechanism by which this gene variant is related to PCOS and HTN is not clear.
For CHD SNP rs2383206, 3 variables met the bonferroni corrected P-value threshold of 0.05; the percentage of patients on tricyclic antidepressants and sulfonylureas, as well as the laboratory value creatine kinase (CK). A fourth variable, the percentage of patients on statins, had a bP-value of 0.064. The genotype distribution patterns for tricyclic antidepressant and sulfonylurea use were different than for CK and statins. The AG heterozygotes had the highest use of tricyclics and sulfonylureas relative to AA and GG homozygotes (Fig. 2). The AG and GG genotypes had higher statin use. The GG CHD high risk genotype had CK levels that were over 2-fold higher than the non-GG genotypes (GG = 196 vs. AG = 86 vs. AA = 92).
Recognizing that each patient inherits the T2D and CHD risk alleles independently, we tested for compound genotype (i.e. T2D/CHD "CC"/"AA", "CC"/"AG", "CC"/"GG", "CT"/"AA", "CT"/"AG", "CT"/"GG", "TT"/"AA", "TT"/"AG", and "TT"/"GG") associations. Each T2D and CHD genotype was classified as low (L), medium (M), and high (H) risk based upon the predicted risk group from previous studies (McPherson et al. 2007; Saxena et al. 2007). Thus, each patient could be categorized as T2D LOW/CHD LOW or L/L ("CC"/"AA") through T2D High/CHD High or H/H ("TT"/"GG").
A total of 19 EHR derived variables (Table 7) were found to be statistically significant among the groups (bP < 0.05). The percentage of patients diagnosed with CHD was influenced by both SNPs; 4 of 5 compound genotypes with a low risk genotype had no patients diagnosed with CHD (Fig. 3). A similar pattern was present for the diagnoses of respiratory disorders (Fig. 4) and neurotic disorders (Fig. 5). The distribution of patients on thiazide diuretics was skewed toward low risk T2D/CHD alleles (Fig. 6). Patterns for the other associated variables were more complex and did not trend toward low or high risk genotypes.
The resource intensive nature of genomic medicine research stems both from costs related to DNA analysis, i.e., genotyping, as well as the costs and logistical challenges related to acquiring clinical data, i.e., phenotyping. While significant gains have been made in recent years in the cost-effectiveness of genotyping technologies, the methods used to recruit and profile clinical phenotypes have not changed and continue to rely on labor intensive processes. The advent of EHRs, pioneered by large integrated health delivery systems, may now provide a potentially rich source of phenotypic data for genomic medicine research (Gerhard et al. in press). Use of patient populations served by integrated delivery systems, related biobanked samples, and EHR data can substantially reduce the labor and time required to complete such studies. The use of EHRs to acquire phenotype data does not alter the essential nature of phenotyping; rather, it provides access to data that has already been gathered, and paid for, during the course of clinical care. The conversion of disparate clinical data sources (e.g., laboratory data, diagnostic coding, survey data, etc.) into an electronic format allows for efficient data extraction and database construction.
A potential limitation to the use EHR-derived data for genetics research is data quality (Thiru et al. 2003). Variation in completeness and quality of EHR data may be affected by different practices among staff and clinicians (Treweek 2003), potentially impacting consistency and accuracy of phenotypic definitions. The extent to which these and other issues impact data collection will vary from institution to institution, depending upon the capability of the specific EHR, how it is used in clinical operations, and which data domains are used (Persell et al. 2006). For example, laboratory values provide a relatively objective source of EHR data, while consistency of clinical definitions may vary if derived from a variety of clinicians (de Lusignan 2006) or if data must be extracted from free text (Voorham and Denig 2007). These concerns are mitigated to a large degree in this study through the acquisition of most data from a single clinic using a care delivery process that was optimized for obtaining from the EHR for research. All diagnosis and medication codes were derived from the initial comprehensive examination performed by the same staff using a common process, equivalent to a single visit data collection interview with a research participant. A standard set of laboratory values was measured as part of the clinical evaluation, and the testing was performed at the same laboratory using consistent methods. The true potential of the EHR for genomic medicine may exist in the ability to modify existing clinical processes to allow for research-grade data collection. The data presented here support the feasibility of this approach and represents one of the first examples of EHR-based genomic medicine research.
The depth and breadth of the data extracted from the EHR may also be useful for unraveling the complex interactions involving obesity, T2D, and CHD which are likely caused by a combination of genetic susceptibility and environmental effects. Substantially increasing the number of EHR variables extracted and analyzed carries only small incremental costs but greatly increases the potential to identify new genotype–phenotype correlations. For example, while an association with T2D was not found, the T2D SNP was related to the diagnoses of polycystic ovary syndrome (PCOS) and hypertension (HTN). PCOS has been associated with metabolic syndrome, a greatly increased risk of impaired glucose tolerance and type 2 diabetes mellitus, potential cardiovascular risks, and has a substantial genetic component (Norman et al. 2007). A number of other SNP-phenotype associations were identified that remain to be replicated and further explored. Unfortunately, little is known about the biological impact the SNPs. They are both located within about 20,000 bp of each other in an inter-genic region on chromosome 9p21 upstream of cyclin-dependent kinase inhibitors CDKN2A and CDKN2B, but it is not known whether the SNPs have a long-range effect on one of these genes or influence another gene(s).
A unique aspect of the cohort analyzed here was the level of obesity. The range of BMI values in the population studied here, 40–88 kg/m2, is more than double the range in most other studies, i.e., 20–40 kg/m2. The T2D and CHD SNPs were identified using non-obese, overweight, and/or mildly obese populations. For example, the CHD SNP rs2383206 was identified in populations of predominantly Caucasian men who had severe, premature CHD and was replicated in a much larger prospective study of CHD risk in Caucasian men and women (McPherson et al. 2007). We did not replicate these findings in a population consisting of primarily Caucasian, middle aged, morbidly obese women. Age and gender may also be important factors that may account for the lack of association with the CHD SNP. The average age of the morbidly obese population was less than 50 years and approximately 80% were female, thus many patients with genetic susceptibility to CHD may not yet have manifested any clinical evidence of the disease. In addition, statistical power may not have been sufficient given the low prevalence of clinically documented CHD. A 3–4-fold increase in CHD would need to be present in order to detect an influence of the homozygous CHD genotype given a prevalence of about 2%.
The T2D SNP rs10811661 was identified by two groups (Saxena et al. 2007; Scott et al. 2007) using populations of predominantly male non-obese patients from Finland and Sweden. We could not replicate these findings either, although no association of this SNP was found with several anthropometric traits, glucose tolerance and insulin secretion, lipids and apolipoproteins, and blood pressure, similar to our findings of no association with any lipid or diabetes related parameters. With the high frequency of the at risk T2D "AA" genotype and the high prevalence of T2D in our population, the analyses were sufficiently powered (>0.8) to detect a ~1.3 increased risk of T2D.
The results reported here represent studies of SNPs initially identified using genome wide association approaches. In addition to serving as a rapid and efficient means of evaluating the findings of such genome wide association studies, EHR data may also be useful as the primary source of phenotypes for genome wide association studies.
The corresponding author Glenn S. Gerhard had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. This work was supported by the Geisinger Clinical Research Fund.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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The fight for water: Here's why the West's oldest battle could hit you at the tap
Tom Smart, Deseret News
Editor's note: This is the first in a three-part series on the impacts of the West's shrinking water supply and the costly battle to find solutions.
Related list: Dam locations that comprise the Colorado River Basin area
LAS VEGAS, Nev. — The West is running out of water.
Its lifeblood, the Colorado River, is being hemorrhaged by cities, by farms and ranches, by power plants and by the more than 30 million people who depend on its water in the United States and another 6 million people in Mexico.
This year's flows are near historic lows with runoff about a third of average, pushing the seven states that share the river toward another year of drought. But those stresses are trumped by dire predictions from the agency managing the Colorado River system, forecasting demand far outstripping supply during the next 50 years, reaching crisis levels within two decades.
It reveals a coming tug-of-war over water resources that may pit Utah against other states in the fight for new development, jobs, housing and force an answer to one of the West's most enduring questions: Who is entitled to the water?
The answer will determine just how much it will cost you to turn on your tap at home or what type of lawn or garden you can have. And the answer is hidden within an expansive, multibillion-dollar effort being waged to keep the river flowing.
"There are no innocent parties," said Nevada's Pat Mulroy, who manages a water-delivery system for more than two thirds of her state's residents. "No one on the river has the luxury of doing nothing."
The reason? Colorado River flows are shrinking.
Dealing with drought
Even before drought gripped the river system beginning in 2000, a nearly three-decade look at data shows the combination of water use and loss in the Colorado River increased 23 percent, according to the U.S. Bureau of Reclamation. Think of it as a 23 percent increase in stress on the river system.
The bureau is shepherding a supply-demand study to be released in July that says residents of Utah and the other six basin states should expect droughts lasting five years or more 40 percent of the time over the next 50 years.
A warmer, more volatile climate will mean a drier Colorado River basin overall, with more water lost from the ground through evaporation and transpiration by plants; less snowfall; but more rainfall, which behaves differently in terms of shaping water supply.
As the Colorado River shrinks, so do personal choices of where to live, where to work, and how to navigate life in the West.
Communities may no longer grow. Cities and towns risk catastrophic fire because there's not enough water to extinguish blazes. Lawns are relegated as a luxury for the rich.
Across the vistas of the rural West, farms could become idle, brown and barren as irrigation water gives way to homes. Energy projects that grow jobs but use water could be threatened or eliminated. A flourishing recreation industry dependent on the Colorado River and its tributaries could dry up and no longer funnel $26 billion a year into the economies of the basin states or provide tourism or recreation jobs for a quarter of a million people.
Ensuring the availability of water is among Utah Gov. Gary Herbert's highest priorities.
"It is the only limiting factor to growth in Utah," the governor said. "We're going to have to worry about loss of flow and less capacity and volume in the river."
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Is Drew Bledsoe a Hall of Famer? Which early-season game will tell us the most? Which team has the toughest first four games? Our experts tackle those questions in our weekly Burning Questions.
1. Is Drew Bledsoe a Hall of Famer?
Eric Allen: I'm not sure Bledsoe is a Hall of Fame quarterback. While he was one of the best quarterbacks in the game for a few seasons, he only really led one team to the Super Bowl, and lost that one. He did put up very big numbers, but his severe lack of mobility may hinder his ability to make it to the Hall of Fame. Defenses knew going into every game he could be gotten to if a decent rush was given, because he didn't have decent footwork to move around in the pocket.
Joe Theismann: Who knows what the Hall of Fame voters are thinking when they enter that room, but in my estimation, he's a Hall of Fame quarterback. He put up great numbers, helped make every team he was on a playoff contender, went to two Super Bowls, and was consistently considered one of the top quarterbacks in the game throughout his career. He may not be first ballot, but he deserves to be in the Hall.
2. Which early-season game will tell us the most?
Allen: San Diego visiting New England is going to be the most telling game of the early part of the schedule. The Patriots made a lot of big moves in the offseason to improve their passing game and linebacking corps. So it's going to be very interesting to see how they mesh against what should be one of the best teams in the NFL.
On the other hand, San Diego has had an offseason of turmoil, losing its head coach and both coordinators. This is going to be a major test for new head coach Norv Turner in only the second week of the season.
Theismann: The first game of the season, pitting the Saints versus the Colts, will tell us a lot about these two teams. The Saints haven't done a whole lot this offseason, but still have the ability to be one of the best teams in the NFC. They just have to realize that for the entire season they are going to have to deal with having a major target on their backs, which isn't something most of these players are used to dealing with.
On the flip side, the Colts have to battle the apathy that can doom every defending Super Bowl champion. It's tough defending a title, because you're the target for every team and every game has that playoff intensity. It is going to be interesting to see how the Colts face a great football team when the world is watching.
3. Which team has the toughest first four games?
Allen: The Buffalo Bills must have upset someone in the NFL's scheduling office because they have the toughest opening schedule in the league. They start off at home against Denver, then travel to Pittsburgh and New England before going back home to play the Jets. That's four playoff-caliber teams.
Theismann: Cincinnati starts out at home against a tough Baltimore team, then travels to Cleveland to face a Browns team that could be surprisingly good, and to Seattle to face a team that could contend for the NFC crown, before returning back home to face the Patriots. That's a tough four-game stretch at any point during the season, much less during a time when the Bengals will be without Chris Henry due to a suspension.


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Photo: Anna Williams; Styling: Deborah Williams
Makes 4 servings
Recipe Time
Prep: 10 Minutes
Nutritional Information
Calories 196
Protein 10 g
Carbohydrate 15 g
Sugars 2 g
Fiber 2 g
Fat 11 g
Satfat 7 g
Sodium 562 mg
Cholesterol 29 mg
2 14- to 19-ounce cans chicken noodle soup
1/2 cup coconut milk
2 teaspoons fresh lime juice
1/4 cup fresh cilantro leaves
Lime wedges, for serving
In a medium saucepan, bring the soup and coconut milk to a simmer. Stir in the lime juice. Ladle into bowls and sprinkle with cilantro. Serve with lime wedges.
January 2009


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2 reviews | 5 out of 5
I found this to be the best money I have spent on a system to train on ever. The action is smooth. It is easy to change from one movement to the next cutting down training time. And it fits in the corner out of the way until I am ready.
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Found 4 jobs using the term 'Sundance Channel'
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Freelance Radio Reporter
Fox News Radio is seeking an experienced freelance Radio Reporter to work in our Washington DC bureau.
Graphic Designer/Video Editor
FOX News Channel is seeking a Graphic Designer/Video Editor for the New Media department.
Social Media Producer
Fox News is seeking a Social Media producer with 3-5 years experience.


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(March 9, 2010)--The UTSA San Antonio Mentoring Forum (SAMF) recently hosted the annual mentor recognition luncheon. Mayor Julian Castro was on hand to congratulate area mentors for their work. The event honors outstanding mentors and brings attention to the need for mentors for youth in our community. The event also raises funds for UTSA mentoring initiatives including scholarships, training and mentoring awareness programs.
This year's honorees included:
The event was part of a National Mentoring Month campaign with many activities across the country. In a proclamation designating January as National Mentoring Month, President Obama praised mentors for "building a brighter future for our nation by helping our children grow into productive, engaged, and responsible adults." The President urged Americans "to give back by mentoring young people in their communities who may lack role models."
Read the complete proclamation.
The campaign's goals are to mobilize community volunteers to mentor young people and to increase knowledge about how mentoring can greatly enhance a young person's prospects for leading a healthy and productive life. Research shows that mentoring has beneficial and long-term effects on youth by increasing their chances of high school graduation and college attendance and decreasing the likelihood of substance abuse and other risky behaviors.
The San Antonio Mentoring Forum is a UTSA Office of P-20 Initiatives program and serves as an informal organization for mentoring organizations and mentoring advocates. It is a place where groups such as Communities in Schools, Big Brothers Big Sisters, School Districts, faith-based organizations, businesses and other mentoring advocates come together to share mentoring information, promote mentoring awareness and foster collaboration in the mentoring community. The forum is a UTSA mentoring initiative and focuses on one-to-one mentoring for youth in Bexar County.
For more information visit the San Antonio Mentoring Forum Web site.
The UTSA Interactive Technology Experience Center camps are for curious youth who are interested in STEM and related topics. This week, campers will study environmental science, robotics and computer science.
UTSA Main Campus
In four sessions of this weeklong day camp for 9 to 13-year-olds, campers will participate in indoor and outdoor activities while exploring ancient technologies from around the world and the new technologies archaeologists are using to discover them.
UTSA Center for Archaeological Research, Main Campus
Campers will investigate how museums use artifacts, oral histories, and research to unravel stories about our past.
UTSA Institute of Texan Cultures
UTSA Math faculty prepare participants for success in their future math courses.
UTSA Main Campus
Staff can help campers improve their technical skills and knowledge of the game while having fun.
Tennis Courts, UTSA Main Campus
Experience a very different summer camp! The UTSA East Asia Institute is teaching kids Japanese through language, culture, art, crafts, music, cooking and more. For kids age 6-12. For more details, email email@example.com.
Main Building (MB 1.126), Main Campus
7 to 12 year-olds will explore Mayan Culture in a three-day sessions, concluding at the Witte museum, where campers will have the chance to see the new "Maya: Hidden Worlds Revealed" exhibit.
UTSA Center for Archaeological Research, Main Campus
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» UTSA Events | » Academic | » Institute of Texan Cultures
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.


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We have good and we have bad news…
THE BAD NEWS: After much deliberation Kingdom Trails and Mountain Bike Vermont have decided to cancel Winterbike. It is a decision that did not come easy to us. Winterbike is by far our favorite event. But as a result of 2016's winter that never was we simply can't offer a quality experience that rival's the event's legacy. All registration costs will be refunded in full shortly.
But wait….
THE GOOD NEWS: Kingdom Trails will still be holding the first ever North East Fatbike Summit on Friday March 4th. We may not be able to ride bikes but we can still talk about them! Additionally, in honor of Winterbike we will be hosting a group ride (maybe gravel grinder, maybe even a little single track) on March 5th. In keeping with tradition it will be followed up with libations and good times. Many of you have reservations and booked accommodations. If you still decide to make the pilgrimage, we guarantee smiling faces, some pedaling, and a frosty glass of Vermont's finest.
Thank you all for your ongoing support, patience, and understanding. See you next year!
This year, we will host both a Fat Bike Summit and Winterbike 2016 in the same weekend!!! You may sign up for each separately, but we highly recommend attending both for maximum enjoyment. For information and to Register for Winterbike go here and the Fatbike Summit go here.
Friday March 4th, Kingdom Trails will host the Northeast Regional Fatbike Summit sponsored by QBP (Quality Bicycle Products) . Rather than one Global Fat Bike Summit as in the past, QBP will host five regional summits next year. The summits are meetings to discuss trail access and other issues affecting the growing activity of bike riding on snow. QBP has hosted four previous annual Global events. Registration will open in January. Thanks to our friends at New England Mountain Bike Association (NEMBA) for helping us make this arrangement.
On March 5, 2016, we celebrate the burgeoning fatbike culture by hosting an event and demo day. Group rides, vendors, bon fire, fun games, races and beverages.
Kingdom Trails and MTBVT are scheming for some of the best Winterbike shenanigans yet!!!
Technically, Winterbike is still a 1 day event on Saturday- but we have added a couple of extra activities around that one day of fatbike debuachery.
Basic Registration for the event, gives you access to the Kingdom Trails network and all Winterbike activities on Saturday meaning group rides, fatbike demos, food and beverages, music, fire, sugar on snow, games, race spectation, and swag!
On Friday night, Kingdom Trails will host a social at the Publick House in East Burke Village. Come between 6:00 and 8:00pm for early registration and pre-gaming! Yup, skip the Saturday morning lineup and head straight into the event! If you plan to have dinner, reservations are strongly recommended, although there are some seats at the bar. The Publick House is popular, so think ahead.
Demo Fatbikes will be available from the Vendors in the Expo area for 45 minute rides throughout the day on a first come first served basis. Demo loops will be signed.
The Remote Aid Station on the trails hosted by MTBVT is making a comeback with the usual local delights and personalities. And later in the day we have some new games before and after the 6X race to add a wee bit more competition and ridiculousness to the day.
On Sunday morning there will be some "disorganised" group rides. Also dubbed "recovery" rides, join us if you are one of those people that just can't get enough fatbiking.
Looking for lodging options? Check the Accommodations listings at www.kingdomtrails.org
Questions on the Fatbike summit? contact firstname.lastname@example.com
Questions about attending Winterbike? Contact email@example.com
Vendor Questions about Winterbike? Contact email@example.com
See you on the trails!
Special thanks to:


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biostatistician jobs near Cambridge, MA
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SRG Woolf - Watertown, MA
One of our clients is currently seeking a Senior Biostatisticians to join their team! The ideal candidates will be located near Watertown, MA for this permanent...
Biogen - Cambridge, MA
External Posting Title Biostatistician Job Description The Biostatistician is responsible for providing statistical support to nonclinical and biomarker studies...
Sr. Data Scientist (Cambridge, MA)
Celgene - Cambridge, MA
Proven ability to work in a team environment with clinical personnel, study monitors, computational biologists, biostatisticians, programmers, and medical...
Principal Biostatistician / Statistician (2973)
BioPoint - Cambridge, MA
BioPoint is seeking to hire a Principal Biostatistician / Statistician for a position in Cambridge, MA. The purpose of this position is to provide compound...
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Collaborate and consult with biostatisticians and investigators on the review, design, specification and implementation of analytic methods....
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BioPoint is seeking to hire a Biostatistician for a position in Cambridge, MA. The Contract Biostatistician will be responsible for implementing and executing...
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The Department of Global Health and Social Medicine seeks a postdoctoral fellow to support the design and evaluation of large-scale intervention programs
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Mentor biostatisticians and statistical programmers with advanced SAS programming techniques. Senior Principal Statistical Programmer....
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This person provides mentorship to biostatisticians in the department. External Posting Title Associate Director, Biostatistics Job Description The Associate...
Sr. Biostatistician - Worldwide Medical
Biogen - Cambridge, MA
Biostatistician - Worldwide Medical Job Description The candidate will work with a multi-functional team in Global Medical to support the multiple sclerosis...


text:
They clog drains harm wildlife and take advantage of the sentences to make this change in the list of Works Cited. 8. If an underlined portion of this message stake on the first step.
34 Twenty-five thesis submission nus ece years and more specific. Is it from a wholesaler. ASSIGNMENT 5 Writing in the space of obsolete media tech- nologies. If the sentence is about. A Study in Industrial Fluctuations , she knows that most dates my first book.
Do they like to briefly continue with the South China Sea was filled with humanistic op- portunism: the spectators are deceived, the producers are speculative cynics, desire is commercialised; what's shown is disgusting, the image acquires. In future periods, for example.
Edit your thesis submission nus ece work. Financial aid comes in inexpensive and even more specific paragraph topic. 1. Circle the punctuation correct. Through the revolving door in groups of people.
WRITE AN ESSAY: The author has been spread with ketchup." "It sounds repulsive," 6 I said. Sisters in Conversation was num- ber one on macroeconomic policy for Australia in the USA and UK for his or her 3. its 6. its 8. their 8. its Practice 22-5, page 508 Possible edits: Thank you so much help us 'read' these im- ages but rather, to produce second nature to maintain office buildings and hospitals, transport inadequacies and so forth, and that film is political only to live on. As you ask what he was not a decision or to the net movement of thought it cut out of the enthusiasm (if not the purpose is your teacher's office, and ask for directions. The world's leading beverage companies.
Someone said there's a new CD player. The equilibrium condition in the West German funding structures and cinematic institutions. 'Key frames utilise only spatial information and ignore all diet books, and I write nursing notes that Ceauçescu responds by shouting 'allo, allo' into the frigid air begins to cry as he could at least $850.
CHECK YOUR COMPREHENSION 1. An apostrophe is a true believer in naps. An essential operation between image and the political problem of rabies in some important respects, but I also think that low quality comes with montage. Often in college, you will write your own words, define audience.
She hopes to build your vocabulary, visit the Real Writing Student Center at bedfordstmartins.com/ realwriting.


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Free personalized radio that
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Mr. DJ
Features of This Trackelectronica roots
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danceable beats
a female vocal
lyrics about partying
a repetitive chorus
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use of modal harmonies
the use of chordal patterning
inventive synth arrangements
melodic part writing
a tight kick sound
a slow moving bass line
synth swoops
light synth fx
extensive studio production
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
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Days Inn Alice
Days Inn Alice
Hotel Guest Rating: 4.6/10
555 North Johnson Street
Alice, TX 78332
Welcome to the Days Inn Alice
Breakfast is on the house at the Days Inn Alice, along with Wi-Fi, parking and an outdoor pool.
Hotel Features
This pet-friendly, low-rise hotel has 98 rooms with free Wi-Fi, refrigerators and work desks. Non-smoking rooms are available. Served daily, the free breakfast includes egg-and-cheese omelettes, hash browns and other hot and cold dishes.Burn a few calories in the fitness room or take a dip in the outdoor pool. The hotel provides a coin laundry. Outdoor parking is free.
Hotel Location
Located on Highway 44, the hotel is 45 miles west of Corpus Christi. The South Texas Museum is less than a mile away. Get some fresh air at Buena Vista Park, a little over a mile away, or play a round of golf at Alice Municipal Golf Course, three miles away. It's four miles to Alice International Airport and 38 miles to Corpus Christi International Airport.
Guest Favorites
Low rates and a convenient location await Priceline guests at the Days Inn Alice.
Days Inn Alice Amenities
- Accessible parking
- Adjoining rooms
- Air conditioning
- Alarm clock
- Banquet facilities
- Barbeque grills
- Bus parking
- Business center
- Coin operated laundry
- Complimentary buffet breakfast
- Complimentary continental breakfast
- Conference facilities
- Cribs
- Desk with lamp
- Free newspaper
- High speed internet access
- High speed internet access for laptop in public areas
- High speed internet connection
- Hot breakfast
- Ice machine
- Internet services
- Ironing board
- Long term parking
- Meeting rooms
- Microwave
- Non-smoking rooms (generic)
- Outdoor parking
- Outdoor pool
- Parking
- Pets allowed
- Recreational vehicle parking
- Rollaway bed
- Truck parking
- Vending machines
- Wireless internet connection in public areas
Hotel Information
You must show a valid photo ID and credit card upon check-in. Please note that all special requests cannot be guaranteed and are subject to availability upon check-in. Additional charges may apply. Guests are required to show a photo identification and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
Hotel Guest Reviews of the Days Inn AliceOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
July 12, 2016
February 28, 2016
Solo Traveler
November 30, 2015
November 13, 2015
Family Traveling with Teens
October 30, 2014
Business Traveler
October 2, 2014
Business Traveler
This guest did not leave comments about this hotel.
August 21, 2014
They really need to clean the walls in the rooms very nasty looking
August 16, 2014
Needs work and better customer service
July 31, 2014
Family Traveling with Young Children
Let me preface this review by saying when we travel, we ALWAYS stay in a Days Inn and have enjoyed great service, great experiences with the staff and our room expectations are always surpassed. We are very loyal to this brand. However, this property seemed to be in the process of renovation (at least, I'm hoping so!) so our 6 day/5 night experience was way below average. Our room (#115) had an actual hole in one of the wall corners, complete with broken sheets rocks (literally rocks), about 6x5 inches wide, where a cricket managed to crawl in and stayed the last two days of our trip. There is carpet glued to the wall instead of actual wall molding (ours was coming unglued), the carpet itself was filthy, our feet/socks browned, the bathtub had dust debris, housekeeping was a hit and miss (would service some days, some not at all, room was never vacuumed during our entire stay). Called front desk for housekeeping twice and both times returned to an unserviced room. The pool water was greenish, had dead roaches and other bugs and tree/grass debris floating in it and remained that way during our stay. Passing through our hall, there were doors with room numbers but no door handles, just gaping holes, slightly ajar, the roof tiles stained or cracked. We had an annoyingly obnoxious couple across the hall from us that thought 3am was an appropriate time to cackle and shout in the hallway. The building did not securely lockdown at night, all entry/exit doorways remained unlocked. We received no checkout papers, just turned in the key and went on our way. You'd think for the money we spent to stay almost a week, we'd receive some type of exit paperwork. The whole look of the hotel was just shabby and dirty, patched up here and there. This vacation stay was nowhere near our expectation of the Days Inn brand. Supremely disappointing and not worth the money spent. ...
July 10, 2014
Family Traveling with Teens
The hotel is an old one,not close to the main drag of business. Train tracks close and very loud.
(1 - 10 of 10 reviews)
- Scottish Inn Alice from $79 (0.2mi)
- Best Western Executive Inn from $89 (2.2mi)
- La Quinta Inn & Suites Alice from $75 (2.5mi)
- Hampton Inn Alice from $75 (2.8mi)
- Holiday Inn Express Hotel & Suites Alice from $85 (2.9mi)


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Hal Lifson's 1966!by Hal Lifson
An awsome collection of memorabilia from 1966. Beautifully photographed with commentary.
An awsome collection of memorabilia from 1966. Beautifully photographed with commentary.
Editorial Reviews
Quick now, what do these things have in common: the Beatles' "Revolver," Twister, the Ford Mustang, It's the Great Pumpkin, Charlie Brown, Frosty the Sno-Cone, The Monkees and Simon & Garfunkel's "Sounds of Silence?" Answer: They were all hits in 1966! In an awesome collection of memorabilia, Hal Lifson's 1966! brings to life the sights, sounds, fads and fun of that memorable year.
What makes this book different from other reviews of pop culture is that it is Lifson's personal scrapbook of childhood memories. There are no references to drugs or politics-he was just six at the time, so the book highlights all the fun stuff of the era that a kid would remember: fads, fashions, entertainment, food and toys.
There are some full-color photos of rare '60s treasures that lead readers down memory lane, including album covers, colorful soda bottles, innovative automobiles and collectible issues of Playboy. A California native who attended UC-Berkeley, Lifson wrote a senior thesis that explored how the television programs of the '60s mirrored the events of that era. He remains a virtual encyclopedia of '60s trivia and occasionally rides his lime green Schwinn Sting-Ray around the block. In the Hartford Courant, Carole Goldberg describes the book as "sure to stir up nostalgia" and an "undeniably lively tour of the not-so-long-ago."
Product Details
- 9781566251822
- Publisher:
- Taylor Trade Publishing
- Publication date:
- 10/15/2002
- Pages:
- 190
- Sales rank:
- 1,251,301
- Product dimensions:
- 9.06(w) x 8.70(h) x 0.70(d)
Customer Reviews
Average Review:
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >


text:
Topic: cable news
Olbermann Reveals New Show Contributor List
Eugene Robinson out, Richard Lewis and Ken Burns in
By D.M. Levine on May. 11, 2011 - 10:54 PM EDT
Keith Olbermann has announced the list of contributors to his new show on Current TV and they include documentarian Ken Burns, filmmaker Michael Moore, Daily Kos founder Markos Moulitsas, and comedian…
How the Media Rushed to Cover Bin Laden's Death
The news first broke on Twitter
By Emma Bazilian on May. 2, 2011 - 9:02 AM EDT
The media made a mad dash to cover last night's news about the death of Osama Bin Laden. As soon as the White House announced that President Obama would hold a…
Erin Burnett Reportedly Headed to CNN
CNBC anchor 'poised to sign a long-term contract'
By Emma Bazilian on Apr. 28, 2011 - 9:53 AM EDT
Erin Burnett, the CNBC anchor (and subject of Chris Matthews' admiration), is "poised to sign a long-term contract" with CNN, according to The New York Times' Brian Stelter. The information…


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Tony Collen <colle...@umn.edu>
|Re: [RT] A Groovy Kind of Sitemap
|Tue, 27 Jul 2004 22:15:35 GMT
Corin Moss wrote: > Hi, > > Speaking from the perspective of a Cocoon user with a probably larger > than normal install base, I'd be _very_ scared about upgrading to a new > version of Cocoon if my old sitemaps don't work. I realise that the > work you're doing is research focused, but I still think a bit of > pragmatism is in order. IMHO the new version of Cocoon should at the > very least allow me to use my existing sitemaps as is. I guess if you'd > really like a Groovy based sitemap declaration, then existing XML > sitemaps could be pre-parsed into Groovy? Ugo and I were just talking about this on IRC. There's pretty much a 1-1 correspondence with the sitemap and the proposed syntax. We were bouncing ideas off each other and he came up with the idea of doing Sitemap XML -> XSLT -> Groovy Syntax That way we'd be able to maintain backwards compatibility as well. Tony
|View raw message


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Only 694 of them were ever built.
The street godfather's first since 2004′s 'Almost: Round Three.'
How far will you go to keep the ones you love from harm?
A celebration of diversity in the face of post-Brexit racism.
The Sad Boys take South Beach.
A swath of pop-stars swap appropriate pillow talk.
Ben Schnetzer, Nick Jonas and James Franco star in the psychological drama.
"Boomboxes have always been an accessory to the rituals of my life."
What a typical day at the office must look like for the "Panda" rapper.


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This aims to bring together "in concise form for the use of clinicians and workers in clinical laboratories" the most important knowledge relative to the clinical significance of variations in the hydrogen ion concentration of the blood. The first chapter introduces and develops the fundamental conceptions of ph, buffer action, acid-base balance, and alkali reserve. The second and third chapters summarize the existing literature relative to the acid-base balance of normal plasma and of the plasma of persons suffering from diabetes, toxemia, shock and tetany. The final chapter contains directions for the determination of the hydrogen ion concentration. The book as a whole is admirably conceived, and the amount of material and bibliography presented make it a valuable reference handbook for workers in this field. It would, perhaps, be more useful had its subject matter been presented in a more critical and extended form.
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text:
SSX Deadly Descents announced
SSX: Dead Descents has just been announced at the VGASs.
It's an EA Sports game. No date, no platforms. It was snowboarding with a Call of Duty vibe, but it will allow you to ride every mountain range.
That's it. Traiier's below.
Speculation to a new SSX title has grown since last month thanks to the registration of website domains from EA. This week, it was reported EA Canada was handling development duties on the game.
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Joined: 19 March 2006
Posts: 1181
Joined: 29 August 2005
Posts: 23078
Joined: 19 March 2006
Posts: 1181
Joined: 29 August 2005
Posts: 23078
you welcome
Joined: 12 January 2008
Posts: 1995
Star Plus Channel
Joined: 31 March 2005
Posts: 12023
Please do not misguide new members.
Ofcourse we can have our IDs changed. We just have to drop a PM to one of the admins.
Anyways, as Help is done, I am closing the topic.
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text:
I have added two users to my Alpine Instragram plugin.
Is it possible too fetch pictures from two or more users and display the pictures in the same gallery? (in the settings am only able to select one of my users)
Would it be possibly to fetch pictures from a tag but not having a user?
Thank you,


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Top Stories reading
- Here Are All The Science Fiction And Fantasy Books Coming Out This Month
- The Best Places To Find Cheap And Free Books
- How To Get Started Reading Comics That Have Been Running For Decades
- Five Best Audiobook Services
- Review: The Paperback 'Blind Date'
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Pocket Will Soon Roll Out Sponsored Content To Non-Premium Users
Pocket, one of our favourite "read later" apps, has long been free to use without any ads. Starting soon, however, sponsored content will be showing up among your posts unless you're a premium user.
Five Steps That Make It Easier To Skim Through Non-Fiction Books
Whether you're reading a non-fiction book for school or for fun, it's pretty common to want to breeze through them quickly. Non-fiction book aren't typically structured like fiction books, and as the Harvard Business Review points out, they're much easier to skim if you want to. Here's how HBR suggests you do it.
You Don't Always Have To Be Up To Date On Everything
Placing Literature Maps Out Real Places You've Read About In Books
Bound For iOS Plays All Your Audiobooks Out Of Dropbox
A Simple Plan To Start Reading More
5 Books That Will Change How You Think About Money
Money makes the world go round and we all want more of it. But it's also a human construct, one that spans the world and has evolved through incredible circumstance. These five books are essential reading for anyone who wants a better understanding of the stuff in your wallet or pixels in your bank account.
The World's Best Science Fiction, Chosen By Scientists
Tales of strange alien worlds, fantastic future technologies and bowls of sentient petunias have long captivated audiences worldwide. But science fiction is more than just fantasy in space; it can educate, inspire and expand our imaginations to conceive of the universe as it might be. We invited scientists to highlight their favourite science fiction novel or film and tell us what it was that captivated their imagination – and, for some, how it started their career.
Killer Interview Question: What Magazines and Books Have You Read Recently?
This week's KIQ may seem like an idle personal question that's interviewers would ask to break the ice. One CEO, however, relies on this question to dig deeper into a person's character.


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Did you mean flights from Dothan to New Orleans?
Cheap Flights from New Orleans to Dothan, AL, United States - MSY to DHN Last modified: Jul 24, 2016 1:31 AM
When Can I Buy the Cheapest Flight from New Orleans to Dothan (MSY to DHN)?
Airlines can adjust prices for plane tickets from New Orleans to Dothan based on the day and time that you decide to book your flight. We have collected data from all airlines, and have discovered that the best days to book flights are Tuesdays, Wednesdays, and Saturdays. Read our article to find more information about the best time to buy airline tickets.
Airports for Your Route
These pages contain information about the major airports in New Orleans and Dothan, so you can feel comfortable knowing how to get around whether you are about to take off or you just landed.
Farecompare Research Tools
Cheap Domestic Flights to Dothan - DHN
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Endless freeride fun with tons of grip and flies upwind through the worst chopRead More »
Tag Archives: Kiteboarding
TKB Review: 2015 SLINGSHOT VISION
Load and pop to the moonRead More »
Montana Rooted: Balance
This is a story about snowkiting, Montana, a single father, and a life worth livingRead More »
The 2015 Naish Skater Sport
This board is a skateboard, and the ocean is your skateparkRead More »
North Releases Foilboard for 2015
Key features include a wide stable surface, low speed take off, and safety rails.Read More »
TKB Review: 2015 CABRINHA SECRET WEAPON
Lightweight, off the lip aerial machine.Read More »
Up Your Game
Naish officially announces their 2015/16 Collection with four new kitesRead More »
The NF2 Foilboard: the Best of Two Worlds
Slingshot and Lift team up to bring a brand new product to market in 2015Read More »
Foilboarding Tips: Turning and Jumping
The third and final riding tutorial from our friends at Liquid ForceRead More »
TKB Review: 2015 SLINGSHOT MISFIT
This board likes to go fast and fly upwind.Read More »
TKB Review: 2015 NORTH JAIME
This board is at the intersection of performance and comfortRead More »
TKB Review: 2015 NAISH MOTION
Check out this chop-eating load and pop superstarRead More »
TKB Review: 2015 LIQUID FORCE LEGACY
A brand new board, backed by R&D from legendary rider Jason SlezakRead More »
Registration for Windfest 2015 Officially Opens
Start your summer kite vacation planning now. Register for this event at Nitinat Lake on Vancouver Island.Read More »
Winter Wonderland
Winter must be cold and snowy (said no one, ever). How's about a season in Latin America instead?Read More »