text:
Compare Offers on Amazon
Dexter: The Complete Third Season [Blu-ray]
|List Price:
|CDN$ 17.97 & FREE Shipping on orders over CDN$ 25. Details
|You Save:
Today Only: The Magic School Bus: The Complete Series is $25
Deal of the Day: The Magic School Bus: The Complete Series is at a one day special price. Offer valid on July 25, 2016, applies only to purchases of products sold by Amazon.ca, and does not apply to products sold by third-party merchants and other sellers through the Amazon.ca site. Learn more.
Frequently Bought Together
What Other Items Do Customers Buy After Viewing This Item?
Michael C. HallCDN$ 19.97
Product Details
Would you like to update product info, give feedback on images, or tell us about a lower price?
Product Description
Showtime's breakout hit series Dexter, about a lovable psychopath, a serial killer who targets only the scummiest of the scum, hits its stride in season 3. Dexter Morgan, played with nuance and glee by the outstanding Michael C. Hall, begins the season somewhat chastened by the events of the previous season--where whiffs of his secret life became known to others and he was nearly found out. "I need to find out what it's like just to be normal. If that's something that's even possible for me," he muses, as he tries to settle in to domestic life with girlfriend Rita (the baby-voiced Julie Benz) and her kids.
Yet Dexter is soon back to his compulsion for seeking out criminals who've somehow escaped traditional justice. Hall, one of TV's most talented actors, manages to make Dexter's off-kilter moral compass totally believable, if not quite sympathetic. The rest of the cast is stellar, including Dex's sister, Debra, played by Jennifer Carpenter as the seemingly more combustible Morgan--a hot-tempered Miami detective in the same division where Dexter toils in the background as a blood-spatter specialist. Deb wears her heart on her sleeve, as a cop and a sister, and her deep love for her brother is a key part of what makes Dexter so human. (And Carpenter's chemistry with Hall is amped by the fact that in real life, the actors are married.)
Season 3's breakout guest star is the amazing Jimmy Smits, who plays District Attorney Miguel Prado, a polished pillar of the community, an ambitious politician--and a guy with a secret every bit as dark as Dexter's. As Miguel and Dexter peel away each other's unsavory layers, Dexter tries to tamp down Miguel's blistering desire for revenge, and Miguel begins leading a double life--one that could threaten Dexter's life and family as much as the growing list of bad guys in Miguel's crosshairs. The other main star of Dexter is the city of Miami, its teeming beauty and corruption celebrated in equal measure, and its blistering sun shot without tempering. The city is so integral, visually and viscerally, that it's impossible to think of Dexter being shot anywhere else. The set's best extras--engaging interviews with cast members Hall, Benz, Carpenter, Lauren Vélez (Lt. Maria Laguerta) and David Zayas (Det. Angel Batista)--must be watched on a computer, for reasons that are unclear. Still, the interviews are must-sees for all Dexter fans. It's a killer season. --A.T. Hurley
Customers Who Bought This Item Also Bought
Customer Reviews
Top Customer Reviews
That said, the show is still a winner and the changes are subtle.
However, this blu ray release is a loser in my books. All of the extra features have been left off the discs, being relegated instead to the BD Live service. I hate this, as it means that the extras can go away at any time. It's not likely I'll be able to stick this disc in ten years from now and watch them. The biggest issue, however, is that I can't even WATCH them because apparently you have to attach some kind of storage device to your blu ray player to download content. I have never downloaded any content to my player before, yet it says its memory is full. We spent all last evening working on our setup and managed to get to the menu for the on-line content, but none of it would load anyway. It should not consume your evening trying to access content that they could have put on the disc!Read more ›
The plots this season were more all over the map than in previous years. That's not to say "Dexter" has become stale--it hasn't.
After their rocky relationship in Season Two, Dexter and Rita get back together and he eventually pops the question. In the episodes leading up to the wedding, he sometimes questions his ability to be a good husband and parent, but in the Season Finale, a conversation with Harry and certain desperate circumstances convince Dexter he is more than ready and willing to be a family man.
Deb gets a new partner in the cocky but twitchy Quinn, who gives off suspicious vibes for most of the season. Deb jeopardizes her chances of finally getting her shield by sleeping with Quinn's Criminal Informant. Again, things in the romance department don't turn out easy for her. There is a nice scene between her and Dexter as the wedding day approaches and Dex asks her to stand up for him.
With Doakes out of the picture, Angel gets promoted AND gets a girlfriend. The latter comes about through some rather unusual circumstances.
Masuka isn't used nearly enough, and his big moment of the season comes in taking charge of the preparations for Dexter's bachelor party.
But Season Three isn't all about love and marriage.
Dexter's first kill of the season goes awry and he inadvertently ends up offing the kid brother of District Attorney Miguel Prado (Jimmy Smits), who becomes the pivotal figure in Dex's life this 'go-round.
At first Dexter feels uncomfortable getting close and being pals with the man who's kid brother he murdered. But soon he relishes having his first real friend and the two bond until slowly Miguel discovers Dexter's tendencies and beliefs.Read more ›
Most recent customer reviews
I just love this show. After just a few minutes into it you'll be hooked! Its edgy, intoxicating and thrilling.Published 8 days ago by BoogieStreet37
Another great season of one of the best shows in television history in my personal opinion.Published 8 months ago by Slade
I loved it. The twists and turns are more than I expected and I enjoy the comedy sequences. The acting is great.Published on May 24 2014 by Jeannette Quast


text:
Godric the Kingslayer
Sons of Mercia, no. 2
Jayden Woods
Questo libro può essere scaricato con iBooks sul tuo Mac o dispositivo iOS e con iTunes sul tuo computer. I libri devono essere letti con iBooks sia su Mac che su dispositivi iOS.
Godric is the bastard son of Eadric Streona, spurned by Eadric's wife and promised nothing by society. At a young age his life is steeped with murder, loss, and betrayal. Godric seems destined for a life of exile and insignificance, but he swears to avenge his father's death, no matter what the cost.
Living under the roof of Thorkell the Tall, he learns to become a Jomsviking. The life of a warrior brings Godric comfort, but his hunger for vengeance remains. He finds a new identity for himself and successfully reenters the royal court, where he initiates his plans of assassination. As success grows closer, however, he finds himself hurting the people he loves more than the man that he hates. He watches himself become his own worst enemy, and can only hope to change his ways before he tears his own world apart.
- 2,99 €
- Categoria: Genere storico
- Pubblicato: 26/09/2011
- Editore: Jayden Woods
- Pagine: 688
- Lingua: Inglese

subset: commoncrawl


text:
particle physics
Mysterious Subatomic Particle May Represent Exotic New Form of Matter
In the course of exploring the properties of a strange subatomic particle, physicists may have stumbled upon an even more mysterious and exotic new form...
The Art of Physics: Winning Photos of Giant Particle Colliders
Physics laboratories around the world house amazing machines that probe the heart of matter and unlock the secrets of the universe. Incredible as their scientific...
This Just in: Higgs Boson Still Boring
The latest updates from the Large Hadron Collider regarding details of the Higgs boson have so far been a yawn-fest. Physicists from around the world...
Can You Hear the Higgs?
Have you ever wondered what one of the greatest scientific discoveries of our time sounds like? Wonder no longer! After the announcement of the Higgs...
Gold and DNA Could Create New Dark Matter Detector
A combined team of physicists and biologists aim to build a directional dark matter detector using strands of DNA and gold.
How the Discovery of the Higgs Boson Could Break Physics
The announcement of the long-awaited discovery of the Higgs boson may happen on July 4, marking a major achievement and something to celebrate. Or maybe...
Particle-Wave Duality Shown With Largest Molecules Yet
Researchers created an interference pattern for molecules made of 100 atoms -- the largest objects ever shown to reveal the weird quantum effect of particle-wave...
LHC May Have Revealed First Hints of Higgs
Like tech geeks lining up for an iPhone, physicists have long been looking forward to the Higgs boson. Now finally, researchers may have gotten their...
Could a Higgs Boson Announcement Be Imminent From the LHC?
Physicists at the Large Hadron Collider could be getting an early Christmas present: the Higgs boson. According to the latest rumors, scientists at the LHC...
Angels & Demons: The Physics Behind The Movie (and The Book)
I don't remember if I already mentioned it on GeekMom, but I live and teach near Geneva, on the border between France and Switzerland, thus...


text:
Turnabout is an American television situation comedy that first aired on NBC in 1979 and was based on a 1931 novel of the same title by Thorne Smith (which had already been developed into the 1940 movie, Turnabout). The plot was about a husband and wife who found themselves inhabiting each other's bodies, similar to the plot of Freaky Friday. Wikipedia
|2 points


text:
New Neighborhoods
Surrounded By
The Great Outdoors
Introducing Audie Murphy Ranch in Menifee, a new master planned community of beautiful homes, parks and timeless beauty that bonds residents to nature – and each other. Set amidst 1,100 rolling acres, Audie Murphy Ranch is surrounded by mountain vistas, magnificent trees and century-old rock formations.
Spacious New Home Designs with Stunning Views
New neighborhoods are coming to life here surrounded by rugged silhouettes of the San Jacinto and San Bernardino mountains. Just outside your door, miles of meandering trails and community paseos connect you with nature and open space. For the eager outdoor enthusiast, 2.5 miles of community trails weave through the community encouraging family bike rides, evening strolls or early morning hikes.
The AMR Blog!
Enjoy the Farmer's Market at Wickerd Farm
The Menifee Certified Farmers Market & Street Fair is the perfect place to find fresh produce, beautiful flower…


text:
I had booked a reservation for our family to stay here for one night. I walked in and the place did not smell right. I asked to see the room & as the manager & I rode the elevator another guest was complaining about the smell. She said it was pot & that the whole place smelled like it since she checked in the night before. The room was dated, smelled musty & there were stains on the couch. We chose to stay elsewhere that night.
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Orbitz, Priceline, Hotwire, Regatta Hotels, Hotels.com, Odigeo and Travelocity so you can book your Microtel Inn & Suites by Wyndham Sioux Falls reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Microtel Inn And Suites Sioux Falls Hotel Sioux Falls
- Microtel Sioux Falls
- Sioux Falls Microtel


text:
The Eradication of Smallpox: Edward Jenner and The First and Only Eradication of a Human Infectious Disease / Edition 1by Herve Bazin, H. Bazin, Hervi Bazin
Pub. Date: 02/02/2000
Publisher: Elsevier Science
Simply, and with great humanity, The Eradication of Smallpox tells the story of smallpox - it's origins, the horror of the disease, and the millions of people killed or disfigured by it. During the 18th and 19th centuries, it is estimated that one out of every ten people died from the disease; some say one out of every seven. Smallpox attacked very young/b>
Simply, and with great humanity, The Eradication of Smallpox tells the story of smallpox - it's origins, the horror of the disease, and the millions of people killed or disfigured by it. During the 18th and 19th centuries, it is estimated that one out of every ten people died from the disease; some say one out of every seven. Smallpox attacked very young children in particular.
The story progresses with the practice of variolation, the life of Edward Jenner who first proposed 'vaccination' with cow pox vaccine (little James Phipps was the first person ever vaccinated in this way), the years of debate about the efficacy of this novel method, and the later worldwide initiatives to rid the planet of this horrific disease. In 1979, the story culminates in the only total eradication of an infectious disease that mankind has ever accomplished. This year celebrates the 20th anniversary of this momentous achievement.
In the intervening years, debate has raged about what we should do with the remaining smallpox viral stocks. Do we destroy them, so they can't fall into the hands of bioterrorists, or do we maintain them, in case they may be of use in some unexpected way, for therapeutic purposes? These questions are thoroughly discussed in the book.
Key Features
• Covers the background, history and origin of smallpox, and brings the story up to the present day
• Gives full and interesting details of Jenner's life, and tells how this humble country doctor brought about a revolution in vaccination
• Includes many quotes from historical figures
• Features 120 high quality photographs, many originating from unique historical plates in the author's private collection
• Includes new research data
• Provides new views on the eradication and destruction of smallpox
Product Details
- 9780120834754
- Publisher:
- Elsevier Science
- Publication date:
- 02/02/2000
- Pages:
- 246
- Product dimensions:
- 0.63(w) x 6.14(h) x 9.21(d)
Table of Contents
Chronology: The life of Edward Jenner
For those who have forgotten or never knew what smallpox was like:
On the long struggle of man, before Jenner, to fight smallpox.
The life and work of Jenner:
The young Jenner (1749-1772).
Jenner, naturalist and country surgeon.
The myth becomes reality (1795-1798).
Jenner's hard-won victory in England, his own country.
The particular case of Napoleonic France.
Vaccination spreads across Europe and the United States and then throughout the rest of the world.
Honours and resentment for Jenner (1801-1823).
The perfect ending to the story: the eradication of smallpox:
Post-Jennerian vaccination (1823-1979).
Smallpox vaccination: its value and its limitations.
The anti-vaccination movements (1798-1979).
The eradication of smallpox: Jenner's posthumous triumph.
Jenner, vaccination and ethics (1796 to the present day).
What should be done about the smallpox virus?
Some comments on current immunity to smallpox.
Customer Reviews
Average Review:
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >


text:
The Maya Sites – Hidden Treasures of the Rain Forest – Getting Around – Short Guide
With "The Maya Sites – Hidden Treasures of the Rain Forest", I just published the English edition of my travel guide "Die Ruinenstädte der Maya". Are you looking for the perfect travel guide to the Maya sites in Mexico and Guatemala? You found it! The Maya Sites Hidden Treasures of the Rain Forest This book … Continue reading The Maya Sites – Hidden Treasures of the Rain Forest – Getting Around – Short Guide
Getting around Chiapas – Palenque, Bonampak, Yaxchilan
The Exotic Route – Gulf Coast and Chiapas I call this second part of the travel "the exotic route" because from here on we are leaving the main tourist areas. Except of Edzna, our first destination, all sites belong to the pre-classic area of the ancient Maya civilization. The age of the buildings that you … Continue reading Getting around Chiapas – Palenque, Bonampak, Yaxchilan
Mayapan – last big town of the ancient Maya in Yucatan
Mayapan is a historic site of the Maya in the northwest of the Yucatan Peninsula. It is considered to be the last big Mayan town in the history of ancient Mayan civilization. Mayapan was actually the capital of the Maya in Yucatan for a period of about 200 years. The ruins are located about 40 … Continue reading Mayapan – last big town of the ancient Maya in Yucatan
Yaxhá – Pyramids, Temples, a Lake and the Jungle
Yaxha in mayan language means blue-green water. It is the Name of an ancient city of the Maya civilization in the low-lands of Guatemala. The site is located in the Guatemalan state Petén. It is just few miles from the border to Belize. The name is spoken like Yash-Ha. The ancient town was build near the Lake Yaxha. It is surrounded by a … Continue reading Yaxhá – Pyramids, Temples, a Lake and the Jungle
Ek Balam – The Black Jaguar – Riviera Maya
Ek Balam in Mayan language means "Black Jaguar". It was a city of the ancient Mayas in the Mexican state Yucatan around 30 km north of Valladolid and 150 km west of Cancun. In 1997 the excavation was started. According to legends that were recorded by the Spanish government during the 16th century after the … Continue reading Ek Balam – The Black Jaguar – Riviera Maya
Cozumel – Pilgrimage to Ixchel – San Gervasio
Ixchel was the goddess of fertility of the ancient Mayas. She was associated with several different attributes like the moon, water, child birth or the rain bow. She was one of several Jaguar Gods to which the ancient Mayas did worship to. An image of the Dresden Codex shows an old woman with claws instead … Continue reading Cozumel – Pilgrimage to Ixchel – San Gervasio
Edzna – Campeche – Pyramid with Living-Rooms
Have you ever visited the ruins of Edzna in Campeche ? Not many people find their way to this amazing city of the ancient Mayas. Edzna – The House of the Itza in Campeche The city is located 1 hour by car from Campeche, the capital of the state of Campeche and around 3 hours from Merida. … Continue reading Edzna – Campeche – Pyramid with Living-Rooms
Tonina – House of the Big Stones – Chiapas – Mexico
From a distance, Tonina seems to be one of highest Maya pyramids you have ever seen. The huge building rises up to a height of 71 m (233ft) above the place in front of it. Several remains of temple buildings are located on the seven levels that create it's basic structure. In fact, it is … Continue reading Tonina – House of the Big Stones – Chiapas – Mexico
Chichen Itza – Yucatan – Mexico – Most Famous Maya Pyramid
Chichen Itza is the most famous archaeological site with old Maya temples and pyramids in Mexico. It is a very popular travel destination for tourists who spend their vacation time at the Riviera Maya due its amazing buildings, temples and pyramids. Chichen Itza can be reached within 3 hours by car or bus from Cancun. … Continue reading Chichen Itza – Yucatan – Mexico – Most Famous Maya Pyramid
Palenque – Misty and Mystic
High temperatures and humidity will accompany you when you go for a visit of the ancient Maya town Palenque. The ruins of this town were covered by jungle for more than 1000 years. When the archaeologist Stephens visited Palenque in 1841 he had to cut a path through the jungle. Today it's quite simple to get there. The city … Continue reading Palenque – Misty and Mystic


text:
Certificate IV in Building and Construction - Estimating
Certificate IV
|Mid Year Intake?
|Study Mode
|Entry Requirements
|OTEN - Strathfield
Year 12 or equivalent
Course Description
This qualification is part of the Construction, Plumbing and Services Training Package. It is designed to meet the needs of estimators and schedulers in the building and construction field.
Subjects you can Study
Core: Apply risk management techniques; Apply building codes and standards to the construction process for low rise building projects; Identify and produce estimated costs for building and construction projects; Produce labour and material schedules for ordering; Apply structural principles to residential low rise constructions; Apply structural principles to commercial low rise constructions; Read and interpret plans and specifications; Prepare and evaluate tender documentation. Electives: Contribute to the implementation of strategies to control OHS risk; Apply quality management techniques; Select and prepare a construction contract; Select, procure and store construction materials for low rise projects; Prepare simple building sketches and drawings; Prepare specifications for all construction works; Build thermally efficient and sustainable structures; plus more.
About TAFE NSWRTO code: curriculum
Certificate IVCourse code: CPC40308
OTEN - Strathfield
15 units: 8 core; 7 elective
Entry Requirements
Year 12 or equivalent
To gain entry into this course you are required to hold the OHS Induction Training (White Card).
Life after Study
Related Careers
Quantity Surveyor
Quantity surveyors prepare cost estimates and plans, audit projects, manage costs and administer contracts, for all levels and types of construction.


text:
4357. huntsvle
Quoting wunderkidcayman:
I'm just replying to THIS quote because it's the most recent...but to whomever, I don't think anyone is disappointed that a storm doesn't play into a major hurricane. The majority of us would be incredibly affected if that were to happen. Most of us blogging live somewhere that could be obliterated by a major hurricane. Don't confuse our enthusiasm with concern. If it didn't actually matter, there wouldn't be theories and updates flying like crazy. Don't assume things you don't know. Everyone might be a bit pride hurt when they're personal evaluations don't pan out, but please don't attack someone over that. That's not the case. No one is sitting around getting off to the thought of a cat 5 making landfall. Perhaps you shouldn't parlay your guilty thoughts into someone elses actions.
Member Since: Posts: Comments:


text:
You have free access to this content
Clinical Decision Rules to Improve Adverse Drug Events
Version of Record online: 20 NOV 2012
DOI: 10.1111/acem.12004
© 2012 by the Society for Academic Emergency Medicine
Academic Emergency Medicine
Volume 19, Issue 11, page 1313, November 2012
Additional Information
How to Cite
Roulet, L., Ballereau, F., Asseray, N. (2012), Clinical Decision Rules to Improve Adverse Drug Events. Academic Emergency Medicine, 19: 1313. doi: 10.1111/acem.12004
Publication History
- Issue online: 20 NOV 2012
- Version of Record online: 20 NOV 2012
- 1Clinical decision rules to improve the detection of adverse drug events in emergency department patients. Acad Emerg Med. 2012; 19:640–9., , , et al.
- 2Emergency physician recognition of adverse drug-related events in elder patients presenting to an emergency department. Acad Emerg Med. 2005; 12:197–205., , , et al.


text:
Comments about 'Archuleta, Paisley rock the crowd at Stadium of Fire'
- Oldest first
- Newest first
- Most recommended
What's with all these places celebrating the 4th of July on the 2nd of July this year??? It's unpatriotic.
- 1:17 a.m. July 3, 2011
- Like (2)
- Report abuse
Glad the children (first two comments) can read the news and have no fear of
retribution for their silly opinions. Geesh.
Having lived out here for the past 15 years I'm very grateful for the those that put forth so much effort in the organization of the Freedom Festival. It's a grand event and one that has become a pretty regular tradition in our family. Living in Utah is great, being part of the 4th celebration in Provo is the best!
Because of a university study that shows most parade watchers are of the Republican Party we will once again flock to the parade and recharge our conservative batteries! Come join us on Center Street at 5am!
Thank you City of Provo and Freedom Festival organizers! We love it!
- 12:02 p.m. July 3, 2011
- Like (2)
- Report abuse
It allows people to go to multiple events.
- 12:45 p.m. July 3, 2011
- Like (1)
- Report abuse
I think it is ok to show patriotism more than just one day a year.
- 3:22 p.m. July 3, 2011
- Like (5)
- Report abuse
Yeeesh. The seats were very expensive... Wish the nosebleed seats were more reasonable. Sigh.
- 3:29 p.m. July 3, 2011
- Like (2)
- Report abuse
I would hope that we celebrate our freedom more than once a year and that we find ways to bless others that were not given so much.
- 3:29 p.m. July 3, 2011
- Like (2)
- Report abuse
The "Stadium of Fire" --- always on a Saturday --- is one of the most patriotic events in the USA, and it features some of the best talent in the nation.
- 3:33 p.m. July 3, 2011
- Like (2)
- Report abuse
If the country would show half of the patriotism the rest of the year as it does on July 4th we would be a stronger country. I love everything that Utah does to celebrate the 4th of July. I wish I lived closer so that I could attend like I used to do.
- 5:35 p.m. July 3, 2011
- Like (1)
- Report abuse
Wasn't there a flyover by the squad from Hill Air Force Base? No mention of the
men and women flying to freedom fighter jets?
- 6:04 p.m. July 3, 2011
- Like (1)
- Report abuse
Thank goodness we are Free!!!! America is the greatest place in the world to live!!!
- 7:00 p.m. July 3, 2011
- Like (2)
- Report abuse
Does anyone know how our president celebrated Americas birthday?
- 9:41 p.m. July 4, 2011
- Like
- Report abuse
Rocked the crowd at the stadium of fire? Whoever said they were rock? If this
concert rocked it would have been Tesla,Queensryche,Bon
Jovi,Styx,Kansas,Dokken,Great White,or Sammy Hagar at the event.
People dont know what rock is anymore. Katty Perry does not rock. Justin Beiber does not rock. U2 does not rock. Lady Gaga does not rock.
Pop is not rock. Only rock can rock and be rock dude!
- 8:07 p.m. July 5, 2011
- Like
- Report abuse
Obviously you are a big Brad Paisly fan. I wanted to read more about other acts before his show. Too much descriptions about his performances whereas many fans complained that the crowd was not really enthusiastic about his show. In some other articles, they described each opening act. Also some said David Archuleta's patriotic medley was really touching, honoring what Stadium of Fire was all about, and he got standing ovation. You should be covering more broad perspectives instead of a fan boy's perspective.
- 9:56 a.m. July 6, 2011
- Like (2)
- Report abuse
DeseretNews.com encourages a civil dialogue among its readers. We welcome your thoughtful comments.
— About comments
- 2 homes, 3 other buildings damaged in...
- Author, activist speaks at Theodore Roosevelt...
- Man accused of killing UTA worker dies in prison
- Women underrepresented across Utah's...
- Mike Lee, US Senate to hold monument meeting...
- 7 tips for summer travel while pregnant
- Roy home destroyed in fire
- Man shot by roommate in Holladay, police say
- Utah Democrats headed to 'historic'... 29
- Should mountain biking be allowed in... 28
- LDS Church asks court to void subpoena... 12
- Mike Lee, US Senate to hold monument... 9
- Women underrepresented across Utah's... 8
- Brother, sister hugged each other as... 8
- Prosecutors say Jeremy Johnson should... 7
- Audit of embattled S.L. County... 7


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Leszek Gawron <lgaw...@mobilebox.pl>
|Re: [CForms] Creating an intermediate object in binding
|Fri, 29 Jul 2005 14:34:25 GMT
Ugo Cei wrote: > Let's assume I have a Person class: > > public class Person { > public String getFirstname(); > public String getLastname(); > public Address getAddress(); > ... > } > > and an Address class: > > public class Address { > public String getStreet(); > public String getTown(); > ... > } > > I am building a form interface for editing a Person, with this binding: > > <fb:value id="street" path="address/street"/> > > Now, when trying to save the form, JXPath will do a > jxpathContext.createPathAndSetValue which will fail because > person.getAddress() is null and the JXPath context doesn't know how to > create an Address. > > I could work around this problem by making sure person.address is not > null before loading it into the form, but I don't like this solution. A > better option, maybe, would be setting a factory on the context, like > is shown here: http://jakarta.apache.org/commons/jxpath/users- > guide.html#Creating%20Objects > > My problem is: where do I set this factory in CForms, assuming this is > possible at all? I do not think this is possible in current implementation (I am not sure though). Still the approach implemented by JXPath does not scale well - you would have to duplicate all info about relationships in your OR model. There is one more thing that is awkward with binding: imagine you have a OR model with many-to-many relationship. Cforms will allow you to create a form with a selection list to define those relationships. But wait: what you get are the ids of entities not entities themselves. Binding API does not give you access to service manager so you won't be able to lookup some dao and load the entity by its id. -- Leszek Gawron email@example.com IT Manager MobileBox sp. z o.o. +48 (61) 855 06 67 http://www.mobilebox.pl mobile: +48 (501) 720 812 fax: +48 (61) 853 29 65
|View raw message


text:
For a brief moment following a Bloomberg report, the Internet thought hot dating app Tinder was worth $5 billion.
That's off by a lot, an IAC executive tells Forbes and sources tell Business Insider.
OKCupid co-founder Sam Yagan, who works for IAC, tells Forbes' Jeff Bercovici: "I can confirm on the record that we did a transaction with Chamath, but this valuation is nowhere near the truth."
Two LA startup executives who aren't directly tied to Tinder tell Business Insider that IAC purchased a chunk of Tinder from former Facebooker and investor Chamath Palihapitiya for $50 million at an estimated $500 million valuation. Bloomberg initially reported the sale price at $500 million for a $5 billion Tinder valuation.
Chamath Palihapitiya just debunked the Bloomberg report in a tweet too:
IAC already owned a majority stake in the app it helped incubate before the deal. Tinder is a dating app that works a lot like hot-or-not. In January, Tinder was creating 10 million matches for its users per day.
See Also:
Note: First and last names are required for commenting. If you do not provide your first and last name when signing up, you will be banned.
Location, ST | website.com


text:
Matt Damon and Jimmy Kimmel Go to Couples Therapy Again. Does It Work This Time?
- 03:22 PM, Jul 26
Leonard Cohen Performs for A Live Audience
Photo credit: / WENN
To fit your screen, we scale this picture smaller than its actual size. The original picture size is 712x1000 pixels and this photo has been viewed 884 times since August 21, 2012


text:
JAZZ went from 55 cents to over $190 per share in 75 months (6 years 3 months). That is from 4/2009 to 7/2015. After only 3 years it was aleady at 50 bucks per share.
I will hold SNTA/MADG until election time 2020. I am confident the price wil be over $20 pps.
Allow me to give you some INCY historical pricing:
$12pps on 11/2011....fast forward 27 months....
$78pps on 2/2014......fast forward 19 months.....
$125pps on 9/2015
Thank God for Dr. Paul A. Friedman saving our sinking ship !!!
Dr.Friedman will make my portfolio GREAT again !!!
Sentiment: Strong Buy


text:
Top Definition
A series of acnes spread around the lips and lower region of the face.
I was about to go in for the kill, but then i saw these two HUGE tkrebs, not cute.
po Dablazer Јул 2, 2006
Trending Now
Email-ovi se šalju sa firstname.lastname@example.com. Nikada vas nećemo spam-ovati.×


text:
The greatest sporting event on earth starts next week — the NCAA Basketball Tournament — and, well, while we're on the subject, anybody know what happened to Jimmer Fredette?
He's about, oh, 6-foot-2, with 200 muscled pounds and a face that looks like he stepped out of Mayberry or a Norman Rockwell painting.
Has anyone filed a missing persons report?
Is he on a milk carton?
Maybe he's on a Carnival Cruise ship and that explains it.
You remember Fredette, don't you? Everyone does. He was a national sensation, the boyish, charismatic kid from BYU who never met a shot he didn't like. He started shooting as soon as he pulled into the parking lot. He was so good and so popular that his name became a verb — when he dropped 40 points on a team, the team got Jimmered.
He led the nation in scoring — 31 points per game. He led BYU to the Sweet 16. He was everyone's All-American, everyone's Player of the Year, everyone's favorite player, everyone's cover boy. If you tuned in Dan Patrick or Jim Rome or the local TV gab show, chances are they were all talking about Jimmer, and so were people at the water cooler.
He was bigger than basketball. So big that he became a pop hero. He was Taylor Swift, with a basketball.
The president of the United States weighed in, calling him "unbelievable. Best scorer obviously in the country."
The Internet was flooded with highlight videos and Jimmer songs to the extent that one BYU student made the mistake of chastising people for worshipping Jimmer. Wrong move. She got Jimmered by the wrath of Jimmer Nation. His story was everywhere — developing his game in the LDS Church gym with his aspiring rapper/big brother TJ, playing against prison teams, working with a personal trainer as a 5-year-old, etc.
How big of a deal was Jimmer? BYU arranged to play a game in Jimmer's way-out-of-the-way hometown of Glen Falls, N.Y.
But you probably already know all this as we stroll down memory lane. Fredette cemented his legend in the post-season conference tournament and the NCAA tournament — 52 points against New Mexico, 32 points against Wofford, 34 points against Gonzaga.
You name it, Jimmer won it, including every award named after old guys — Wooden Award, Adolph Rupp Trophy, Oscar Robertson Trophy, Naismith Award.
This all happened some time during the Vietnam War — oh, wait, it was only two years ago! It just seems like ancient history. No one has seen Jimmer since then. How could a guy like that be missing? He should be easier to find than Craig Sager.
Well, according to reliable sources, Jimmer has been spotted playing guard for the Sacramento Kings. Actually, playing might be the wrong word. Sitting would be more accurate. Jimmer, according to some reports, plays only 14 minutes a game — down from 18 in his rookie season. Rumor has it that he averages 7 points a game. Seven points? He used to score that before the first commercial break.
He was the 10th pick of the 2011 NBA Draft, and it looked like Sacramento would carry on with the Jimmermania. His jersey number sold out immediately; ticket sales took off.
And that was about it.
It pretty much fizzled. Jimmer started seven games as rookie. He has zero starts this season and didn't play at all in nine games.
During a four-game stretch in December Jimmer scored 16, 15, 22 and 10 points, respectively — 63 points in 79 minutes of play. Four games later, he never left the bench.
At the very least, this guy should be Danny Ainge II. Who can figure what college player's game will translate to the NBA game. The NBA isn't as patient as Major League Baseball or the National Football League. He could pretty much be written off after another year, if things don't change. He could join the ranks of Adam Morrison and JJ. Redick as college stars whose games didn't carry over to the NBA.
Maybe Jimmer could ask his NBA coach about what that's like. Keith Smart famously hit a jump shot to win the NCAA championship for Indiana in 1987. His NBA career consisted of two games, and then he went off to play for the San Miguel Beermen in the Phillippines.
Jimmer fans hope for a better fate for Jimmer.
email: email@example.com
- ACC, ESPN extend deal to 2036 that includes...
- NBA moving All-Star Game out of Charlotte,...
- Brazil nabs 10 IS backers in Olympics...
- Oklahoma State forward Tyrek Coger dies after...
- Jeff Gordon readies for the Brickyard in...
- Froome crashes in Tour, finishes stage with...
- Former NFL coach Dennis Green dies at 67
- Warriors' Draymond Green settles assault case...
- Morning links: National college... 81
- Nine Big 12 candidates: The pros and cons 68
- Report: Tom Holmoe tells Big 12 he's... 66
- Finding a Power 5 home for all BYU... 53
- Annual instate college basketball... 38
- BYU football coaching staff upbeat... 33
- Phil Steele 2016 Football magazine... 29
- Pac-12 South: Bruins the favorite, but... 22


text:
Assume $M$ is a set, in which all axioms of $ZF - P + (V=L)$ hold. Does then $M$ believe that there exists an uncountable ordinal? I mean, why should the class of all countable ordinal numbers be a set?
No. One cannot prove that $\omega_1$ exists in ZF - P, with or without V = L.
The set $HC$ of hereditarily countable sets always satisfies ZF - P. (This is straightforward to check axiom per axiom.) Of course, $\omega_1 \notin HC$ but moreover every set in $HC$ is countable or finite as witnessed by a function in $HC$. Therefore, $HC$ knows that every set in $HC$ is countable and hence $HC$ is a model of ZF - P + "every set is at most countable."
Throwing in V = L into the mix doesn't help. Indeed, $HC^L = L_{\omega_1^L}$ (see my answer to your recent MO question for a proof) is a model of ZF - P + V = L + "every set is at most countable."


text:
The Are you Dominant or submissive Test
Their result for The Are you Dominant or submissive Test ...
The submissive one
You scored ###
Their Analysis (Vertical line = Average)
They scored 43% on domsub, higher than 27% of your peers.
All possible test results
The slave
Whoa! You spend a lot of time on your knees and pleasing your partner. You make decisions which are clearly for the benefit of maintaining a relationship that lands your parter at the top of the teete... Read more
The submissive one
Based on these results, we can see that you're submissive. You dont sacrifice your own desires for your partner, but you certainly put your partner's needs before your own, and you are relatively obed... Read more
The Assertive Sub
You are assertive, yet still maintain some level of submission. You stand your ground firmly most of the time, and are fairly level. You may not identify with being submissive or dominant, and it's po... Read more
The Master
DOM DOM DOM -- You are DEFINITELY dominant. You control the relationship, and your partner, and you like it. You don't like being left out of the loop most of the time, and you're very certain of your... Read more
Recent Results
nonoyesfromspace24 / m / Straight
tmontgom334 / f / Straight
JanexRose19 / f / Straight
momoftwins729 / f / Straight
izzyposen21 / m / Straight
Tests others are taking
xibritrix44 / m / Straight
symmetryof934 / f / Straight
aaronplayguitar35 / m / Straight
The How good is your first message Test
maritime_murse224 / m / Straight
andthenthattoo44 / m / Straight
More tests we think you'll like
Taken 1671 times.
O teste das facções
Find out witch of Divergent faction you belong.
Taken 3124 times.
The How over METAL are you? Test
You can only do so much with metal, and the music is following the same path as the worldly element did. when the first metal was smelted it revolutio...
Taken 2026 times.
The Dog Facts Test
This is my first test and it contains 50 questions of various facts about dogs. Each question is scored 2 points so there is a possible 100 points. ...
Taken 2086 times.
The Megaman NES Test
Hi! And welcome to my Megaman NES Test. I will ask you questions about the Megaman NES saga! Some questions will be easy, others will be hard! Good l...
Taken 3504 times.
The PROGRESSIVE ROCK music Test
Hi! And welcome to my Progressive Rock music Test. I'll be using advanced logic and knowledge to determine if this music appeals to your tastes and yo...
Taken 12332 times.
The Nightclub test
How intelligent are you when it comes to hitting the clubs for an evening?
Taken 240 times.
Test Bloque III [ITIL]
Bloque III - JL (2)
Taken 19793 times.
The Should You Teach High School Test
Find out if I think teaching high school is the right career for you! Keep in mind, it's only my personal opinion. This test will be based on me, basically.
Taken 42815 times.
The Which Wife are You Test
This test is to show which kind of wife you are, or will be (if that is your thing). Remember to answer honestly, otherwise any future spouses out th...
Taken 50731 times.
The dumbest Test
Hi! And welcome to my dumbest Test. I'll be using no logic and little knowledge to determine something.
Connect your existing OkCupid account
Sign in
Welcome Back!
Restore your account to continue meeting new people.
Reset your password
We'll email you a link to reset it.
Email sent!
An email is on its way to .
If you don't see it, try checking your Spam folder.
Enter Authentication Code
Sign in
Not so fast!
You need to complete your basic info on the mobile app before you can use the desktop site.


text:
4 bedroom houses to rent in BA20
Keywords and filters like garden and parking live here
Your search area is too large to further filter your results. Please edit your search location if you would like to filter your results.
Filter your 1 result Clear filters
Property type
Letting type
£1,200 pcm (£277 pw)
4 bed detached house to rentWatercombe Heights, Yeovil, Somerset BA20
Available from 5th Aug 2016
A 4 bedroom detached house in a sought after cul-de sac location. Kitchen, Sitting Room, Dining Room, Utility Room, Cloakroom. 4 bedrooms one with en-suite shower room. Family bathroom. Double garage with electric and two parking spaces in front. ...
Note: Distances are straight line measurements
- Yeovil Junction (2.0 miles)
- Yeovil Pen Mill (2.3 miles)
Latest BA20 4 bedroom houses to rent
Zoopla is one of the UK's leading property portals, helping you to find property for sale and to rent and make smarter decisions when buying and renting homes in the UK. Discover information on homes in BA20 by researching BA20 property values, BA20 house prices paid, our BA20 property market overview and find BA20 agents.


text:
North East Scotland, with an overall average price of £217,776, was similar in terms of sold prices to nearby Edinburgh and Lothian (£217,028), but was more expensive than Highlands and Islands (£157,697) and Central Scotland (£152,773). The most expensive area within North East Scotland was Aberdeenshire (£217,776) and the cheapest was Aberdeen (County) (£211,246).
Overall sold prices in North East Scotland over the last year were 6% down on the previous year and 5% down on the 2006 level of £229,579.


text:
You are currently signed in as .
0 Items in Your Cart
Vault Guides are THE source for insider insight on career information and employer reviews. Shop Vault Guides
Vault Verdict: As a growing force in the
world of economic consulting, Frontier is looking for a very
specific type of candidate: proven interest and expertise in
economics is a given, but the ability to relate to clients and
colleagues is also highly sought-after at...
Vault partners with thousands of colleges, universities and academic institutions to provide students with FREE access to our premium content. To determine if your school is a partner, please enter your school email address below.
Subscribe Now
Contact your Career Center, Alumni Office
and Library to find out more.
Please select your institution
to gain full access.


text:
An Undone Fairy Tale
An Undone Fairy Tale
Simon & Schuster Children's Publishing, Hardcover, 9780689866777, 32pp.
Publication Date: October 1, 2005
List Price: $18.99*
* Individual store prices may vary.
Buy at Local Store
Enter your zip code below to purchase from an indie close to you.
Buy Here
Now, Ned and I admire how well you read. But the story will be ruined if you turn the page right now.
So please don't.
A beautiful pie-making princess is trapped in a tower. Can Sir Wilbur rescue her? And more importantly, can he do it while wearing a tutu? He's going to try! But if you read the story too quickly, Ned won't be able to make the pictures or costumes in time. And happily-ever-after may start to go a bit haywire.
Join Ian Lendler and Whitney Martin for a fairy tale that takes off into hilarious uncharted territory -- all because you won't slow down!
About the Author
When Ian Lendler was younger, he really enjoyed acting in the theater. He was, however, extremely terrible at it. So he became a writer of children's books ("An Undone Fairy Tale "and" Saturday") and nonfiction. He took a day job de-worming animals at the Stratford-on-Avon Zoo.
Martin was a Sergeant in the U.S. Marine Corp Reserves before his career as an artist.
Martin was a Sergeant in the U.S. Marine Corp Reserves before his career as an artist.


text: President defends domestic NSA program as 'transparent'… I'm no 'Dick Cheney'… The first lie is the biggest one; the second lie is the funniest. It's true you're no Dick Cheney, Obama. The truth is, you're worse, and that takes some doing. Is this man capable of taking *any* responsibility for what he does? Does every [Read More…]


text:
Content is the heart of your successful fundraising strategy.
If you don't sell it, you won't connect with your audience. And if you don't do that, you haven't got a snowball's chance in you know where to persuade folks to give to you to further your mission.
This is where learning to become a master storyteller comes in. I know you've heard this before. Storytelling is the meme du jour. But that doesn't mean you shouldn't pay real attention.


text:
Sports have a distinct way of teaching important, lasting life lessons: Teamwork, selflessness in the quest for the greater good, the value of sacrifice and hard work and perseverance, triumph, failure, passion and the like. Those lessons are forever. They apply in the classroom and the in boardroom and in the living room.
I thought about this for a long time after chatting with Chase Rice. His story is a real-life "Forrest Gump" script, one born from that sports-as-life premise.
Rice is a successful country music singer. He has a song on the radio. That, in itself, means he beat overwhelming odds. For every Kenny Chesney, there are a thousand honky-tonk heroes. Rice also co-wrote one of the most successful commercial country music songs of all time, played major college football, almost won the TV reality show "Survivor" and tossed aside a potential career in NASCAR with the sport's super team because his heart was in Nashville.
He is 27 years old.
To read Marty Smith's full story, Click here.


text:
We were visiting family in the Area and now with twin baby girls, we wanted our own self catering accomodation.
This was ideal, very basic but very clean and everything is there which you need.I find it a shame that only single beds are offered for families.Our girls end up most nights sharing a bed with us which makes it uncomfortable in a single bed and we get no sleep as they are only 1 year old and we worry about them falling out.We had a sauna in our house which is cool but we did not use it...I would prefer a double bed instead.
Facilites on site are also good.We will stay here again.


text:
Source Spots Robert Pattinson and Kristen Stewart at Concert, Confirms Hook Up Suspicions
The walls are closing in around Robert Pattinson and Kristen Stewart.
The whispers of their relationship are growing into screams.
The walls are closing in around Robert Pattinson and Kristen Stewart.
The whispers of their relationship are growing into screams.
Robert Pattinson and Kristen Stewart spent the night together, in the same room, at the Chateau Marmont in Los Angeles last night, according to a report.
A Radar Online spy claims to have verified this, spotting Robsten and an unidentified English guy entering suite 79 of the famous hotel Thursday evening.
This just in: Robert Pattinson is really good looking!
More than just an opinion, this statement is now a fact, as UK Glamour conducted a poll of over 2,000 readers this week. In it, the Twilight Saga hunk was named the sexiest man in the world.
Last week, we asked readers to name the sexiest pretend vampire of all-time.
In less-than-shocking results, Robert Pattinson took home over three-quarters of the votes cast.
Will this finally put an end to the rumors?
When asked by Great Britain's OK! magazine about his relationship with Kristen Stewart, Robert Pattinson gave a simple answer:
It may be impossible to top the New Moon sneak peeks revealed at Comic-Con last month.
Though not the highest quality, these videos depicted actual scenes from the upcoming movie, both of which focused on Taylor Lauter and Robert Pattinson with their shirts off. Hubba. Hubba.
In late June, Stephen Moyer referred to Robert Pattinson as a very bad word.
Now, Entertainment Weekly is stoking the fire of this red hot feud by pitting the actors against one another on the cover of its latest issue.
A couple months ago, we asked if Paul Wesley compared to Robert Pattinson.
Readers responded, overwhelmingly, in the negative. Many seemed aghast that we dared to compare anyone with the Twilight hunk, but it only seemed natural.
Jennifer Love Hewitt may converse with the afterlife on The Ghost Whisperer, but it's a different, unusual creature she seems to truly crush on.
Speaking to MTV News at last week's Comic-Con festival, the actress couldn't hide her extreme affection for a certain famous vampire.
Robert Pattinson doesn't understand all the fuss fans make over him. The actor somehow does not consider himself good looking.
But at least he's a nice, kind-hearted individual.
While fans hyperventilated over their appearance together at Comic-Con last week, the interaction between Robert Pattinson and Kristen Stewart was anything but romantic.
There were even rumors that the movie studio behind New Moon, Summit Entertainment, specifically forbade the rumored couple from getting close to one another in public (more on that below).
He might be considered the best looking individual on the planet, but Robert Pattinson says he's pretty much the same guy that used to walk down the sidewalk unnoticed.
"I'd like to think that I haven't changed that much," the actor said at Comic-Con last week. "Within myself, I don't think I've changed. When I'm walking down the street, I look down a lot more often. It seems to keep building, the magnitude of this franchise."


text:
Best Board Games for Young Children
We love a good game night at our house! Games teach children important life skills–waiting their turn, losing or winning graciously, sharing, and problem-solving. Games can also reinforce math and reading concepts–number recognition, counting, probability, adding and subtracting, and letter and pattern recognition. However, finding a game that is fun for the whole family, especially … Read more


text:
select location
advanced search
Made in Dagenham
at Queen's Theatre
at Queen's Theatre
at New Wolsey Theatre
at New Wolsey Theatre
Casting announced for Trevor Nunn's A Midsummer Night's Dream
Theatre News17 May 2016
Ramps on the Moon to stage The Who's Tommy
Theatre News11 May 2016
Climate-based love story The Edge to tour UK
Theatre News27 Jul 2015
Feed the Beast (Birmingham Repertory Theatre)
Reviews22 Apr 2015
Sign of the Times (Tour)
Reviews28 Jan 2015
Success in Ipswich's New WolseyTheatre bid for national portfolio funding
Theatre News1 Jul 2014
Pulse Festival 2014 – Part Two
Theatre News26 Jun 2014
One Flew Over The Cuckoo's Nest (Ipswich, New Wolsey Studio)
Reviews12 Apr 2013
And Then The Dark (Ipswich, New Wolsey Theatre)
Reviews13 Feb 2013
Sleeping Beauty (Ipswich, New Wolsey Theatre)
Reviews28 Nov 2012
New work and established favourites at the New Wolsey Theatre for Spring 2013
Theatre News29 Oct 2012
Can't Pay? Won't Pay (Ipswich, New Wolsey Theatre Studio)
Reviews10 Oct 2012
Can't Pay? Won't Pay! (Ipswich, New Wolsey Studio)
Reviews10 Oct 2012
Can't Pay? Won't Pay! (Ipswich, New Wolsey Studio)
Reviews10 Oct 2012
Mods and Rox (Ipswich, New Wolsey Theatre)
Reviews12 Sep 2012
Bedroom Farce (Ipswich, New Wolsey Theatre)
Reviews25 Apr 2012
Vernon God Little (Ipswich, New Wolsey Studio)
Reviews19 Apr 2012
Forever Young (tour – Ipswich, New Wolsey Theatre)
Reviews14 Mar 2012
Reasons To Be Cheerful (tour – Ipswich, New Wolsey Theatre)
Reviews17 Feb 2012
Jack and the Beanstalk (Ipswich, New Wolsey Theatre)
Reviews9 Dec 2010
New Wolsey Theatre


text:
Franklin County detectives executed a search warrant Tuesday at a Villa Ridge mobile home in an investigation into the death of a 5-month-old baby.
Sheriff Gary Toelke said deputies responded to No. 11 Sleepy Hollow Trailer Court, off Highway AT, about 8:25 a.m. to a 911 call and found the baby unresponsive. Officers performed CPR until a Meramec Ambulance crew arrived.
You must login to view the full content on this page.
Or, use your linked account:


text:
Rar Password Recovery Solution
A RAR file is a compressed file (just like the zip file) that uses the file name extension .rar. A RAR file can be transported to other pc's more rapidly than uncompressed files.Windows doesn't natively support RAR files, but there are third-party apps that do. To pull out files from a compressed RAR file, you need to use a program that is configured to work with RAR files.
Sometimes files are password protected.This is why you might need a solid and working rar password unlocker.You might have downloaded some zipped password-protected application,book,movie,a lots of people today tend to do it, especially if they wish you do pay for it or do something in exchange. Sometimes you come across an expensive software shared on the forums but without password (or only for premium users) so owing a quality rar password recovery tool might be a very useful thing.In fact todays encryption (RAR3-format files use AES for the encryption algorithm) is not easy to break and there are just couple of tools available that atually can do it including rar password cracker (it will also work as a rar password cracker) you can download from this website.
It can rar password crack most of the files even if the if the password chosen is sufficiently large and strong (which means enormous number of possible combinations (permutations) of letters, symbols and numbers) our rar password remover will decrypt it it might just take a bit longer (up to 20 minutes).We tend to keep our rar password remover updated with new algorithms.It'very user friendly,easy to use and what's important a free tool.It's safe to use and completly adware and virus free.
Use responsively and if you have any questions feel free to contact us.


text:
Favstar gets even better if you sign in.
Gift @McKelvie Favstar Pro to unlock their best tweet!Gift them Pro!
Nobody tell him pic.twitter.com/9xPRSeu3jB
mike huckabee was just a regular man until he was bitten by a radioactive sack of shit
tbf this is how I feel about everything I like pic.twitter.com/ONBbHWUW0S
I didn't see any backlash against selfies when it was rich men paying to have them painted by someone else throughout the centuries.
Alright @kevinwada inspired me so I warmed up with an 80s-inspired Rogue. pic.twitter.com/TpEQ45B6Nm
Kieron asked which pop stars I wanted to reference when we were putting WicDiv together. There was only one. pic.twitter.com/MT6ktTtppm
YER IN WIZZARD, HARRY pic.twitter.com/ALk7Vrjuve
When your facehugger grows up and leaves home to go to university and you're left with empty nest syndrome pic.twitter.com/onb8JDPMfr
Just realised Spider-Man made a living from taking selfies.
why are the tories doing that thing with their legs pic.twitter.com/tuLNXlDEBm
How we talk about fictional characters is absolutely reflective of how we talk about real people
I fixed it. pic.twitter.com/sIdHDIDc7Z
The Wicked + The Divine Comic To Be Adapted As TV Series By Universal TV http://deadline.com/2015/05/the-wicked-the-divine-comic-tv-series-universal-tv-1201434613/ …
Furiosaaaaaaaa pic.twitter.com/zmd8MNIqKU
Does whatever a spider can
Which species?
Never heard
Maybe the kind
That eats bird
Urgh gross
Bird-eating Spider-Man
So I teamed up with @Mighty_Nice to make the new @CHVRCHES @yelyahwilliams video for Bury It: https://www.youtube.com/watch?v=B9BLMNn0PrQ …
One the one side you've got "tell me... do you bleed?" and on the other you've got this pic.twitter.com/ooxAwNqWyF
Men saying "but why would they wait 30 years to make a rape claim? I don't believe it" not realising they are answering their own question
"Come with me if you want to live." pic.twitter.com/BoaiskB1PD
The Wicked + The Divine, ongoing series at @imagecomics. I cannot sanction your buffoonery.
Like @McKelvie's tweets? Send them a Favstar Pro Membership to show you care.Gift them Pro!
Stats can't be shown as @McKelvie hasn't signed in to Favstar recently.


text:
Programming note: Stay up to the minute with all developing stories around the Sochi Olympics with NBC Sports' OlympicTalk blog
It took 60 minutes of regulation, five minutes of overtime, and an eight-round shootout, but the U.S. men's hockey team got the win over Russia in a classic that will be remembered for some time to come.
With international hockey allowing the same shooters to be used multiple times in a shootout, the U.S. chose T.J. Oshie to go six times. He scored four goals in the SO, including the game-winner, to lift the Americans over the Russians, 3-2.
Russia appeared to have taken their own 3-2 lead late in the third period, as a shot from Fedor Tyutin got past U.S. goalie Jonathan Quick. But the net was ruled to have been off of its pegs and the goal was disallowed. In overtime, Patrick Kane's breakaway attempt was denied by Russia goalie Sergei Bobrovsky to set up the shootout…
READ MORE AT OlympicTalk.com


text:
Most read
- Free Classic Regatta Returns to Huntington
- Hot Humid Natsu 2016 Prepares for Fall Con IMAGES
- Remains Believed to be Missing Woman Found
- Rooster's Hosts Princess Night with Mickey and Minnie Mouse IMAGES
- Spook Hunters Visit Pullman Square Marquee Cinema IMAGES
- President Obama Laments GOP Pulled Over $900 Milion from Recovery Act
- A Natsu No Romp for Sailor Moon Crystal and Scouts IMAGES
- Nostalgic Images of Ten Forgotten Huntington Venues
- A Decade Of Dio: 1983-1993 - CD Version of Boxed Set on Sale
- Authorities Request Information on Disappearance of Ohio Woman
Diversity Symposium to feature children's and young adult literature
Dr. Isaac Willis Larison, assistant professor of literacy education at Marshall, said that live sessions will take place on both campuses and that sessions will be transmitted electronically to the alternate campus. In addition to Soentpiet, the program will feature West Virginia writers Anna Egan Smucker and Marc Harshman, who is the Poet Laureate of West Virginia.
There is no charge to attend the symposium, Larison said, but registration is necessary. Please visit www.marshall.edu/diversitysymposium and click on the registration tab to complete the registration for this event. The event will include a continental breakfast, beginning at 8:15 a.m., and lunch at no cost to participants.
Soentpiet was born in South Korea. When he was eight years old, he and his sister were adopted by the Soentpiet family and moved to Hawaii. He studied fine arts and education at Pratt Institute in New York City. His work has been featured in the New York Times, USA Today, the Houston Chronicle and Newsweek.
Smucker has concentrated on books for children. She is the author of a number of books, including No Star Nights, Outside the Window, A History of West Virginia, To Keep the South Manitou Light, and a new book, titled Golden Delicious: A Cinderella Apple Story. She also wrote The Life of Saint Brigid, which tells legends of an early Irish saint, and has had poetry featured in many journals and anthologies. She lives in Bridgeport, W.Va.
Harshman, a native of Indiana, attended Bethany College, graduating in 1973. He earned master's degrees from Yale and the University of Pittsburgh, and taught composition and creative writing at the University of Pittsburgh and West Virginia Northern Community College for a few years before moving on to teach grades 5 and 6 for the Marshall County School System. Now a professional writer and storyteller, he regularly travels throughout the eastern United States, telling stories and honing his craft. As an author, he is known primarily for his picture books for children, but has also published collections of poetry.
Symposium events will take place in the Drinko Library on the Huntington campus and in the Administration Building on the South Charleston campus.
The symposium is sponsored by Marshall's College of Education and Professional Development and the West Virginia Humanities Council. For further information, persons may contact Larison by e-mail firstname.lastname@example.com.


text:
The Landmark Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
Travelers also recommend:
TripAdvisor Reviews The Landmark Hotel Batu Pahat
Travel Blogs from Batu Pahat
Zwischenstation Batu Pahat
Batu Pahat ist eine Stadt an der Nordwestk�ste des Bundesstaates Johor in Malaysia. In Batu Pahat leben 311.862 Menschen. Der Name von der Stadt bedeutet im Malaiischen "gemei�elter Felsen". Seit 2009 ist Batu Pahat der zwanzigstgr��te Ballungsraum in Malaysia in Bezug auf die Bev�lkerung.
Hier haben wir in einem 1991 errichteten Hotel …
Dubai To Kuala Lumpur To Batu Pahat
... its light-coloured buildings.
For those who love nature, this is the jewel in the crown. The scenery in fjord country is simply awesome and no matter how impressive the pictures were, they did not and could not do it justice.
Oslo was not very impressive. Bergen had the Hanseatic Quarter of Bryggen and also the very interesting Fish Market. The view of Norway's second ...
Day 67
... we arrived pretty much on time at 3:30. Just 5 minutes before we arrive Batu Pahat , Mr Tan calls me and me discussed a meeting point. Only fe minutes later he welcomed us beside the street.
After everyone of us arrived, we follow his mercedes Benz to the school, where we get a wonderful welcome with drums, flowers songs, chinese yoyo's and smiles.
Moving on to Melaka
Yesterday I took the express bus from Singapore to Melaka in Malaysia. Melaka is the oldest town in Malaysia It was the capital of the Malaccan Sultanate and the center of the Malay world in the 15th and the 16th century, but then colonised by the Portugese, the Dutch and the English respectively. I was a bit surprised on the taxi ride to the guest house I'd seen recommended on the internet to pass McDonalds, RipCurl and even ...
Kuala Lumpur > Melaka
... a cave... and there were builders drilling into concrete walls, so not so atmospheric. The sunway lagoon however was much better. A theme park and water park in one, waterslides in abundance and two massive lagoon type pools. One of which had real sand on the beach area and, get this... a wave machine so powerful that the waves were surfable!! We left KL on the 30th, for the 2 hour journey to the ...


text:
With the advanced capabilities of today's computer technologies, researchers can now collect vast amounts of information with unprecedented speed. However, gathering information is only one half of a scientific discovery, as the data also need to be analyzed and interpreted. A new center on campus aims to hasten such data-driven discoveries by making expertise and advanced computational tools available to Caltech researchers in many disciplines within the sciences and the humanities.
The new Center for Data-Driven Discovery (CD3), which became operational this fall, is a hub for researchers to apply advanced data exploration and analysis tools to their work in fields such as biology, environmental science, physics, astronomy, chemistry, engineering, and the humanities.
The Caltech center will also complement the resources available at JPL's Center for Data Science and Technology, says director of CD3 and professor of astronomy George Djorgovski.
"Bringing together the research, technical expertise, and respective disciplines of the two centers to form this joint initiative creates a wonderful synergy that will allow us opportunities to explore and innovate new capabilities in data-driven science for many of our sponsors," adds Daniel Crichton, director of the Center for Data Science and Technology at JPL.
At the core of the Caltech center are staff members who specialize in both computational methodology and various domains of science, such as biology, chemistry, and physics. Faculty-led research groups from each of Caltech's six divisions and JPL will be able to collaborate with center staff to find new ways to get the most from their research data. Resources at CD3 will range from data storage and cataloguing that meet the highest "housekeeping" standards, to custom data-analysis methods that combine statistics with machine learning—the development of algorithms that can "learn" from data. The staff will also help develop new research projects that could benefit from large amounts of existing data.
"The volume, quality, and complexity of data are growing such that the tools that we used to use—on our desktops or even on serious computing machines—10 years ago are no longer adequate. These are not problems that can be solved by just buying a bigger computer or better software; we need to actually invent new methods that allow us to make discoveries from these data sets," says Djorgovski.
Rather than turning to off-the-shelf data-analysis methods, Caltech researchers can now collaborate with CD3 staff to develop new customized computational methods and tools that are specialized for their unique goals. For example, astronomers like Djorgovski can use data-driven computing in the development of new ways to quickly scan large digital sky surveys for rare or interesting targets, such as distant quasars or new kinds of supernova explosions—targets that can be examined more closely with telescopes, such as those at the W. M. Keck Observatory, he says.
Mary Kennedy, the Allen and Lenabelle Davis Professor of Biology and a coleader of CD3, says that the center will serve as a bridge between the laboratory-science and computer-science communities at Caltech. In addition to matching up Caltech faculty members with the expertise they will need to analyze their data, the center will also minimize the gap between those communities by providing educational opportunities for undergraduate and graduate students.
"Scientific development has moved so quickly that the education of most experimental scientists has not included the techniques one needs to synthesize or mine large data sets efficiently," Kennedy says. "Another way to say this is that 'domain' sciences—biology, engineering, astronomy, geology, chemistry, sociology, etc.—have developed in isolation from theoretical computer science and mathematics aimed at analysis of high-dimensional data. The goal of the new center is to provide a link between the two."
Work in Kennedy's laboratory focuses on understanding what takes place at the molecular level in the brain when neuronal synapses are altered to store information during learning. She says that methods and tools developed at the new center will assist her group in creating computer simulations that can help them understand how synapses are regulated by enzymes during learning.
"The ability to simulate molecular mechanisms in detail and then test predictions of the simulations with experiments will revolutionize our understanding of highly interconnected control mechanisms in cells," she says. "To some, this seems like science fiction, but it won't stay fictional for long. Caltech needs to lead in these endeavors."
Assistant Professor of Biology Mitchell Guttman says that the center will also be an asset to groups like his that are trying to make sense out of big sets of genomic data. "Biology is becoming a big-data science—genome sequences are available at an unprecedented pace. Whereas it took more than $1 billion to sequence the first genome, it now costs less than $1,000," he says. "Making sense of all this data is a challenge, but it is the future of biomedical research."
In his own work, Guttman studies the genetic code of lncRNAs, a new class of gene that he discovered, largely through computational methods like those available at the new center. "I am excited about the new CD3 center because it represents an opportunity to leverage the best ideas and approaches across disciplines to solve a major challenge in our own research," he says.
But the most valuable findings from the center could be those that stem not from a single project, but from the multidisciplinary collaborations that CD3 will enable, Djorgovski says. "To me, the most interesting outcome is to have successful methodology transfers between different fields—for example, to see if a solution developed in astronomy can be used in biology," he says.
In fact, one such crossover method has already been identified, says Matthew Graham, a computational scientist at the center. "One of the challenges in data-rich science is dealing with very heterogeneous data—data of different types from different instruments," says Graham. "Using the experience and the methods we developed in astronomy for the Virtual Observatory, I worked with biologists to develop a smart data-management system for a collection of expression and gene-integration data for genetic lines in zebrafish. We are now starting a project along similar methodology transfer lines with Professor Barbara Wold's group on RNA genomics."
And, through the discovery of more tools and methods like these, "the center could really develop new projects that bridge the boundaries between different traditional fields through new collaborations," Djorgovski says.
Caltech and City of Hope have signed a memorandum of understanding, formalizing a relationship that encourages researchers from the two institutions to collaborate and share resources in the interest of furthering both basic scientific research and translational projects—those with a medical application.
"Bringing together Caltech and City of Hope researchers will surely result in transformative science and hopefully also new approaches to medical care," says Jacqueline K. Barton, the Arthur and Marian Hanisch Memorial Professor of Chemistry and chair of the Division of Chemistry and Chemical Engineering at Caltech.
"The complementary nature of this partnership is a natural fit between our two institutions," says David Horne, vice provost and associate director of the Beckman Research Institute at City of Hope. "The translational opportunities in therapeutics and devices have never been greater, and this partnership comes at an opportune time to advance health care in oncology, diabetes, and HIV, which are City of Hope's major focus areas."
As a result of the new agreement, City of Hope researchers will have access to several unique Caltech facilities, including the Molecular Observatory, an X-ray crystallography resource with an automated beamline at the Stanford Synchrotron Radiation Laboratory; the Center for Catalysis and Chemical Synthesis, a synthetic-chemistry center that offers robotic instrumentation for high-throughput screening and analysis of chemical entities; and the Center for the Chemistry of Cellular Signaling, which analyzes the systems of molecules that dictate how cells behave and react to their surroundings.
Likewise, Caltech scientists and engineers will be able to access City of Hope's array of core research services, including resources such as the Pathology Core, a facility that provides access to preserved tumors and normal tissues; the Analytical Pharmacology Core Facility, which conducts pharmacokinetic and pharmacodynamic studies for chemotherapy clinical trials and peer-reviewed preclinical studies; the Animal Tumor Model Core, which creates various cancer models in mice for testing novel experimental therapies; and the Translational Research Laboratory, which helps with the design of clinical trials and basic research studies using samples from clinical trials.
"This is a very timely event, and I see it as building a bridge between Caltech and City of Hope that is natural both in proximity and in the way we complement each other," says Peter Dervan, Caltech's Bren Professor of Chemistry. "Caltech has always been very strong in basic fundamental research. But today, Caltech scientists and engineers are genuinely interested in taking the discoveries that we make in chemistry, biochemistry, biology, and bioengineering to real-world practical applications. City of Hope is a renowned medical research center that is only 20 minutes away and can work with us collaboratively on these translational problems. This is going to be a win-win partnership."
The memorandum establishes the Arthur D. Riggs Distinguished Lectureship series, which will bring scientists from across the country to speak at Caltech and City of Hope on current projects in basic research as well as on efforts to predict, prevent, diagnose, treat, and cure such diseases as cancer, diabetes, and HIV.
The first lecture in that series will be delivered on Wednesday, November 19, by a distinguished molecular biologist who knows both Caltech and City of Hope well: Riggs himself. Riggs completed his doctoral work in biochemistry at Caltech in 1966; at City of Hope, he is now a professor of cancer biology and chair of the Department of Diabetes and Metabolic Diseases Research as well as director emeritus of the Beckman Research Institute at City of Hope.
"We are really excited that Art has agreed to be the kickoff lecturer," says Dervan. "By sharing interest in the lectures, researchers at Caltech and City of Hope will share ideas, and I think at the end of the day we're going to be sharing students—postdoctoral coworkers and graduate students—on collaborative projects."
Riggs's lecture, " Reflections on a Career of Collaboration, Mostly with Caltech," will begin at 4 p.m. in Gates Annex 22 at Caltech and is open to the public.
Nitrogen is an essential component of all living systems, playing important roles in everything from proteins and nucleic acids to vitamins. It is the most abundant element in Earth's atmosphere and is literally all around us, but in its gaseous state, N2,, it is inert and useless to most organisms. Something has to convert, or "fix," that nitrogen into a metabolically usable form, such as ammonia. Until about 100 years ago when an industrial-scale technique called the Haber-Bosch process was developed, bacteria were almost wholly responsible for all nitrogen fixation on Earth (lightning and volcanoes fix a small amount of nitrogen). Bacteria accomplish this important chemical conversion using an enzyme called nitrogenase.
"For decades, we have been trying to understand how nitrogenase can interact with this inert gas and carry out this transformation," says Doug Rees, Caltech's Roscoe Gilkey Dickinson Professor of Chemistry and an investigator with the Howard Hughes Medical Institute (HHMI). To fix nitrogen in the laboratory, the Haber-Bosch process requires extremely high temperatures and pressures, yet bacteria are able to complete the conversion under physiological conditions. "We'd love to understand how they do this," he says. "It's a great chemical mystery."
But cracking that mystery has proven extremely difficult using standard chemical techniques. We know that the enzyme is made up of two proteins, the molybdenum iron (MoFe-) protein and the iron (Fe-) protein, which are both required for nitrogen fixation. We also know that the MoFe-protein consists of two metal centers and that one of those is the FeMo-cofactor (also known as "the cofactor") at the active site, where the nitrogen binds and the chemical transformation takes place.
In 1992, Rees and his graduate student, Jongsun Kim (PhD '93), were the first to determine the structure of the MoFe-protein using X-ray crystallography.
"I think that there was a feeling that once you solved the structure, you'd understand how it worked," Rees says. "What we can say 22 years later is that was certainly not the case."
The dream would be to have atmospheric nitrogen bind to the FeMo-cofactor and to stop time so that chemists could sneak a peak at the chemical structure of the protein at that intermediate point. Since it is not possible to freeze time and because the reaction proceeds too quickly to study by standard crystallographic methods, researchers have come up with an alternative. Chemists have been trying to get carbon monoxide, an inhibitor that halts the enzyme's activity but also closely mimics the structure and electronic makeup of N2, to bind to the cofactor and to then crystallize the product relatively quickly so that the structure can be analyzed using X-ray crystallography.
Unfortunately, the cofactor has stubbornly refused to cooperate. "We've demonstrated more times than we'd like that the form of this protein as isolated doesn't bind substrates," explains Rees. "Usually if you want to know how something binds to a protein, you just add it to your protein and study the crystal structure with X-ray crystallography. But we just couldn't get anything bound to this cofactor."
But in order for the cofactor to exist in a form that would bind to a substrate or an inhibitor, several other conditions must be met—for example, the Fe-protein has to be there. In addition, ATP—a molecule that provides energy for many life processes—must be present, along with yet another enzyme system that regenerates the ATP consumed in the reaction and a source of electrons. So although the aim in crystallography is typically to isolate a purified protein, the chemists had to muddy their samples by adding all these other needed components.
After joining Rees's group as a postdoctoral scholar in 2012, Thomas Spatzal spent months working on this problem, tweaking the method he used for trying to get the carbon monoxide to bind to the cofactor and for crystallizing the product. He adjusted parameters such as the protein concentrations, the temperature under which the samples were prepared, and the amount of time he allowed for the crystals to form. Every week, he sent a new set of crystals, frozen with liquid nitrogen, to be analyzed on an X-ray beamline at the Stanford Synchrotron Radiation Lightsource (SSRL) constructed as part of Caltech's Molecular Observatory with support from the Gordon and Betty Moore Foundation. And every week he worked up the data that came back and looked to see if any of the carbon monoxide bound to the active site.
"People have been seeing the resting state of the active site, where nothing was bound, for years," Spatzal says. "It's always the same thing. It never looks any different."
But on a recent Friday morning, Spatzal processed the latest batch of data, and lo and behold, he finally saw what he had been looking for.
"There was a moment where I looked at it and said, 'Hold on. Something looks different there,'" says Spatzal. "I wondered, 'Am I crazy?' You just don't expect it at first."
What he saw was a first—a crystal structure revealing carbon monoxide bound to the FeMo-cofactor. Spatzal, Rees, and their colleagues describe that structure and their methodology in the September 26 issue of the journal Science.
Spatzal figured out a way to optimize the crystallization process by using tiny crystal seeds to accelerate the rate of crystal growth and conducting all manipulations in the presence of carbon monoxide, allowing him to grow nice crystals of the MoFe-protein and then to see where the carbon monoxide was bound to the cofactor.
What he found was surprising. The carbon monoxide took the place of one of the sulfur atoms in the cofactor's original structure, bridging two of its iron atoms. Many people had expected that the carbon monoxide would bind differently, so that it would stick out, adding extra density to the structure. But because it displaced the sulfur, the cofactor only took on a slightly different arrangement of atoms.
In addition, Spatzal showed that when the carbon monoxide is removed, the sulfur can reattach, reactivating the cofactor so that it can once again fix nitrogen.
"As astonishing as this structure was—that the carbon monoxide replaced the sulfur—I think it's even more astonishing that Thomas was able to establish that the cofactor could be reactivated," Rees says. "I don't think anyone had imagined that you would get this sort of rearrangement of the cofactor as part of the interaction."
"You could imagine that if you put an inhibitor on a system, it could damage the metal center and inactivate the protein so that it would no longer do its job. The fact that we can get it back into an active state means that it's not permanently damaged, and that has physiological meaning in terms of how nitrogen fixation occurs in nature," says Spatzal.
The researchers note that this result would still be a long way off without the X-ray crystallography resources of Caltech's Molecular Observatory, which has abundant dedicated time on a beamline at SSRL. "We were really fortunate that the Moore Foundation funded this access to the beamline," says Rees. "That was really essential for this project because it took a lot of optimization to work everything out. We were able to keep regularly sending samples and right away get feedback about how things were working. It's an unbelievable resource."
Additional Caltech authors on the paper, "Ligand binding to the FeMo-cofactor: Structures of CO-bound and reactivated nitrogenase," are Kathryn A. Perez, a graduate student, and James Howard, a visiting associate who is also affiliated with the University of Minnesota and where Rees was a postdoc. Oliver Einsle of the Institut fur Biochemie in Freiburg, Germany, and the Albert-Ludwigs-Universität Freiburg, was a postdoc with Rees as well as Spatzal's thesis advisor and is a coauthor on the paper. Spatzal is an associate with HHMI.
This work was supported by grants from the National Institutes of Health, Deutsche Forschungsgemeinschaft, and the European Research Council N-ABLE project. The Molecular Observatory is supported by the Gordon and Betty Moore Foundation, the Beckman Institute, and the Sanofi-Aventis Bioengineering Research Program at Caltech. Microbiology research at Caltech is supported by the Center for Environmental Microbial Interactions.
Professor of Chemistry Brian Stoltz has been named the winner of the 2015 Mukaiyama Award from the Society of Synthetic Organic Chemistry, Japan. He was noted for "the discovery and development of new reactions and processes for the synthesis of natural products and non-naturally occurring bioactive structures," according to the award citation.
Stoltz's work is aimed at developing new strategies for creating complex molecules with interesting structural, biological, and physical properties. The goal is to use these complex molecules to guide the development of new reaction methodology to extend fundamental knowledge and to potentially lead to useful biological and medical applications.
The Mukaiyama Award, named in honor of Japanese synthetic chemist Teruaki Mukaiyama, comes with a $5,000 award, a medallion, and a certificate. It is given to an individual 45 years old or younger who has made outstanding contributions to synthetic organic chemistry. Each year, two winners are selected, one each from Japanese and non-Japanese nominees. Also being honored this year is Professor Shigehiro Yamaguchi of Nagoya University.
Eric Betzig (BS '83), a group leader at the Howard Hughes Medical Institute's Janelia Farm Research Campus in Ashburn, Virginia, has been awarded the 2014 Nobel Prize in Chemistry along with Stefan W. Hell of the Max Planck Institute for Biophysical Chemistry and William E. Moerner of Stanford University. The three were honored "for the development of super-resolved fluorescence microscopy," a method that allows for the creation of "super-images" with a resolution on the order of nanometers, or billionths of a meter. In essence, the work turns microscopy into "nanoscopy."
The technique developed by the trio overcomes the so-called Abbe diffraction limit, which describes a physical restriction on the sizes of the structures that can be resolved using optical microscopy, showing that, essentially, nothing smaller than one-half the wavelength of light, or about 0.2 microns, can be discerned by these scopes. The result of the Abbe limit is that only the larger structures within cells—organelles like mitochondria, for example—can be resolved and studied with regular microscopes but not individual proteins or even viruses. The restriction is akin to being able to observe the buildings that make up a city but not the city's inhabitants and their activities.
Betzig, building on earlier work by Hell and Moerner, found that it was possible to work around the Abbe limit to create very-high-resolution images of a sample, such as a developing embryo, by using fluorescent proteins that glow when illuminated with a weak pulse of light. Each time the sample is illuminated, a different, sparsely distributed subpopulation of fluorescent proteins will light up and, because the glowing molecules are spaced farther apart than the Abbe diffraction limit, a standard microscope would be able to capture them. Still, each of the images produced in this way has relatively low resolution—that is, they are blurry. Betzig, however realized that by superimposing many such images, he would be able to obtain a sharp super-image, in which nanoscale structures are clearly visible. The new technique was first described in a 2006 paper published in the journal Science.
After Caltech, Betzig, a physics major from Ruddock House, earned an MS (1985) and a PhD (1988) from Cornell University. He worked at AT&T Bell Laboratories until 1994, when he stepped away from academia and science to work for his father's machine tool company. Betzig returned to research in 2002 and joined Janelia in 2005.
To date, 33 Caltech alumni and faculty have won a total of 34 Nobel Prizes. Last year, alumnus Martin Karplus (PhD '54) also received the Chemistry Prize.
It is safe to say that the eye is an amazing biological system. One reason is its keratocyte cells—specialized cells that make up the bulk of the cornea. Unlike most of the other cells in our body, those in the cornea are transparent, making sight possible. Should something happen to make the cornea opaque, blindness results.
Sadly, injuries to the cornea do occur, sometimes in the simplest of ways, such as getting sand in one's eyes and scratching the cornea. The scar tissue that then grows to heal the cornea may have the unwanted side effect of being opaque. This does not happen, however, if the cornea and the tissue around it heal in a very orderly fashion. The question, then: Is it possible to encourage this orderly healing after an injury, thus preserving vision?
Professor of Chemical Engineering Julia Kornfield and graduate student Amy Fu are very much hoping that this is the case. To find out, they have assigned a few students, including Caltech senior and recent SURF fellow Jacqueline Masehi-Lano, to experiment with various growth factors that might inhibit the formation of scar tissue and promote orderly wound healing.
"We chose three growth factors to test because Amy Fu and I read several papers on growth factors that have been able to suppress some types of scar tissue," Masehi-Lano says. "In particular, we want to inhibit the formation of alpha smooth muscle actin, the type of stress fiber that creates opaque scars over corneal wounds. So far, the experiments I've done with cell cultures have worked pretty well, so it looks promising."
Eventually, the researchers hope to encapsulate the growth factors in a hydrogel that is reminiscent of the native cornea. "Our hydrogel starts out as a liquid and gels in situ on the eye," explains Masehi-Lano.
Masehi-Lano is enthusiastic about her experience with the SURF program. This past summer was her second in Kornfield's lab, and last year she was a recipient of an Amgen scholarship. "I'm really grateful that my mentor and my co-mentor have entrusted me with my own project and have allowed me to conduct my own experiments. And since it was my second summer in this lab, I was able to take up a leadership role by training a new SURF student," she says. "For me, SURF has gone beyond research. I've been able to improve my ability to present my research to the general public, which I think is extremely important." Indeed, Masehi-Lano was awarded the Caltech Doris S. Perpall SURF Speaking Competition for delivering the most outstanding oral research presentation.
Masehi-Lano plans to continue in bioengineering and is contemplating an MD/PhD program. "I've always been interested in the medical field, and though I'm committed to doing research," she explains, "I'd like to be able to do clinical trials and directly apply new medical technologies to people."