text:
Diagnostic Tool Provides Additional Therapeutic Treatment Guidance for Third Deadliest Form of Ca...
There are 2 comments on the Newswise story from Jun 1, 2008, titled Diagnostic Tool Provides Additional Therapeutic Treatment Guidance for Third Deadliest Form of Ca.... In it, Newswise reports that:
Genzyme Genetics announced today that it now offers KRAS mutation testing for colorectal cancer.
Join the discussion below, or Read more at Newswise.
Since: Dec 05
#1 Jun 1, 2008
Matching Tumors to Drugs
It is critical that those receiving a drug matched to their tumor fare better than is typically seen with standard chemotherapy. So many cancer patients are chasing mets because the first-line standard therapy did not work. But what happens when there are too many receptors (pathways/mechanisms) and the cancer still continues to grow and divide?
When considering a 'targeted' cancer drug which is believed to act only upon cancer cells that have a specific genetic defect, it is useful to know if a patient's cancer cells do or do not have precisely that defect. Although presence of a 'targeted' defect does not necessarily mean that a drug will be effective, absence of the targeted defect may rule out use of the drug.
Cancer cells have many mutations in many different pathways, so even if one route or two is shut down by a targeted treatment, the cancer cell may be able to use other routes. Targeted drugs have not been accompanied by reliable, specific predictive tests allowing for rational and economical use of these drugs. Molecular diagnostics (genetic profiles) approved often have been mostly or totally ineffective at identifying clinical responders to the various therapies.
Gene profile testing examines a single process within the cell or a relatively small number of processes. The aim is to tell if there is a theoretical predispostion to drug response.
Gene profile testing involves the use of dead, formaldehyde preserved cells that are never exposed to 'targeted' drugs. Gene profile tests cannot tells us anything about uptake of a certain drug into the cell or if the drug will be excluded before it can act or what changes will take place within the cell if the drug successfully enters the cell.
Gene profile tests cannot discriminate among the activities of different drugs within the same class. Instead, it assumes that all drugs within a class will produce precisely the same effect, even though from clinical experience, this is not the case. Nor can Gene profile tests tell us anything about drug combinations.
If you find one or more implicated genes in a patients tumor cells, how do you know if they are functional (is the encoded protein actually produced?). If the protein is produced, is it functional? If the protein is functional, how is it interacting with other functional proteins in the cell?
Are you sure that youve identified every single protein that might influence sensitivity or resistance to these drugs? The "cell" is a system, an integrated, interacting network of genes, proteins and other cellular constituents that produce functions. You need to analyze the systems' response to drug treatments, not just one or a few targets or pathways.
There are many mechanisms/pathways to altered cellular function. Functional profiling measures what happens at the end, rather than the status of the individual mechanisms/pathways. Cancer is a complex disease and needs to be attacked on many fronts.
#2 Sep 23, 2013
I have ordered 2 times from this website PILLSMEDSHOP. COM . I called yesterday the customer care and asked for a discount as i was about to order twice the regular amount.
Tell me when this thread is updated:Subscribe Now Add to my Tracker
Add your comments below
Oncology Discussions
|Last By
|Biden Hosting Cancer Summit to Try to Accelerat...
|Jun 29
|Unsolicited Advice
|Biden hosting cancer summit to try to accelerat...
|Jun 29
|Le Jimbo
|Racially biased cancer doctors spend less time ...
|Jun '16
|Summer Friend
|Thoughts on new CMS rules for billing on ambula...
|Jun '16
|Long-term outcomes in radically treated synchro...
|Jun '16
|why use BIG words
|Screening for breast and cervical cancer is a p...
|May '16
|Three Days 5K
|Not just pets: Dogs, cats may show way to bette...
|May '16
|Dumb Animals
Find what you want!
Search Oncology Forum Now
Copyright © 2016 Topix LLC


text:
Deus Ex Machina
Tuesday evening, after tea and compulsory prayers, the last mouse on Earth tried to hide from Mankind, inside the Machine.
The Deus Ex Machina Collection
Deus Ex Machina 2
The legendary video game is reborn, Deus Ex Machina 2 is a darkly comic cradle-to-grave roller-coaster of your entire life. A surreal journey from before your birth, through the temptations and dangers of your life, and beyond your own death.
With complete rock album soundtrack and the greatest voice on the planet as your narrator – Christopher Lee. Imagine if your life was nothing more than some electronic game.

subset: commoncrawl


text:
Announcement Octopus tentacles for your walls, nose eyeglass stands, merriment and mirth...
Octopus tentacles for your walls, nose eyeglass stands, merriment and mirth...
Leah Yellowbird on Jul 26, 2016
I fucking love this! Worth every penny !
rfilipich on Jul 13, 2016
Just awesome & quik delivery too! Thanx so much! :))
Functional and dysfunctional art, handmade daily
So, what happens is this -
I make these sculptures. I make 'em out of clay or wood or hard coated styrofoam. I take great pains to get the originals right - and then,
Why then I make molds. Silicone rubber molds.
I cast duplicates from these molds out of urethane resin.
Lovely, very durable material.
And in most cases I polish 'em and in some cases I paint 'em.
In every case there are
that need to be performed.
These I do.
And I make little changes, tweaks, here and there, so that over time, the castings become more refined and closer to
I do all of this by hand, by myself.
For you, peaches.
Shop members
Owner, Maker, Designer
Son of an artist, spawner of three more...
Shop policies
Payment options
Returns & exchanges
- Custom or personalized orders
- Perishable products (like food or flowers)
- Digital downloads
- Intimate items (for health/hygiene reasons)
Privacy policy
- To communicate with you about your order
- To fulfill your order
- For legal reasons (like paying taxes)


text:
Rheconnaissance ( Rhocky Rhoad X PR French Vanilla) Half Arabian, over 80% Arabian. Colt. Price can include gelding. He's very well built, athletic…$4,000
Amerhican Honey (Rhocky Rhoad X PR Butter Brickle) Solid Buckskin stunner! Full sibling to 2015 Rheverence (new Pinto World champion)Born 6/25/2016 -…$7,500
RhocksAnne-- 2016 Purebred Arabian filly (Rhocky Rhoad x Jubilee Majic), the full sister to Region 4 Champion Stallion SHIH Dressage Type, Region 4 Champion…$2,000
Ruby is a very nice well broke Molly Mule. She is good to trim feet, clip mane, saddle, bridle and ride. She has been all over the United States trail…$5,500
17 y.o. Appaloosa breeding stallion, He is an own son of 2 time Appaloosa World Champion Cutting Horse "Ima Doc Olena" He is a International Champion Sire…$3,500
6 y.o. mare linebred to the great Leo$3,000
This papered, gentle, buckskin filly is an AQHA yearling. She is a granddaughter of Real Gun (2004 AQHA Superhorse) and great granddaughter of Playgun…$1,000
This papered, gentle, brown filly with buckskin points is an AQHA yearling. She is a granddaughter of Real Gun (2004 AQHA Superhorse) and great granddaughter…$1,000


text:
DAN CARPENTER, THE TRIBUNE: Let's Act Now To Preserve Diablo Canyon Lands
JAMES CONCA, FORBES: New York Chooses A Clean Energy Standard As The Best Way To Lower Carbon
MARITA NOON, AMERICAN SPECTATOR: Trump Energy — Making America Great in a Very Real Way
DANIEL B. PONEMAN, CENTRUS PRESIDENT & CEO: In Pursuit of Global Nuclear Energy Leadership
STEPHEN ANTONY, NEWSMAX: Bernie, Sweden, 'The Three Amigos,' and the Future of US Nuclear Energy
ROBERT BRYCE, NATIONAL REVIEW: Democrats Ignore Inconvenient Math on Nuclear Energy
For Email Marketing you can trust
Russia, China and South Korea 'Should Be Invited To Build UK Nuclear Plants'
Japan Nuclear Cleanup Next Target In Russian Economic Offensive
Report: IAEA Could Benefit From Non-State Funding
India Nuclear Suppliers Group Membership Depends on Signing NPT
China Can Cooperate With India In Nuclear Sector
South Korea shuts Wolsong No.1 Nuclear Reactor; Five Plants Offline
Russia Biggest Support In Creating Uranium Reserve For India
Removing Wylfa Nuclear Plant's Radioactive Fuel 'Priority'
Japan Business Lobby Says Abe Government Can't Rely On Nuclear Energy
Nuclear Hub: India's Andhra Pradesh to Get US, Russian Nuclear Plants
Fourth Ningde Unit Enters Commercial Operation In China's Fujian Province
UAE Gets Closer to Commissioning First Ever Nuclear Plant
UK NDA Reports Reduced Clean-Up Costs
Czech Utility ČEZ Requests EIA For New Dukovany Units
French Parliament Passes Law On Procedures For Cigéo Repository
India Continues to Push China to Support Its Nuclear Supply Group Bid
Third Reactor Vessel Installed At UAE's Barakah Plant
UK Could Leave EU Without Withdrawing From Euratom
French Team To Visit Iran For Talks On Nuclear Fusion
EU Probes France's AREVA Financial Package
French Regulator Suspends Test Certificate At EDF's Nuclear Reactor
IAEA Visit to Russian NPP to Promote State's Nuclear Industry
Rosatom Signs Contract With US On Russian Nuclear Fuel Testing
UK's Bradwell's Deep Clean - A First For Magnox
A Year After Iran Nuclear Deal, What Has Changed?
Russia To Loan Bangladesh $11.4B To Build Nuclear Plant
Japan Pauses For Nuclear Inspections Following Latest Quake
French Unions Walk Out Of Nuclear Sector Meeting With Minister
Grid Connection For China's Second Fangchenggang Unit
Poland Abandons Gaski As Potential Site For First Nuclear Station
Egypt's Dabaa Nuclear Plant Final Contract To Be Completed
Iran Looking Into Bulgaria's Nuclear Offer
How China Won The NSG Membership Power Play
Report: Nuclear Energy Important In China's Future Energy Mix
India's Secretive Nuclear Story: A Tale Of Cheers And Tears
Fiscal Restraints To Keep MENA Nuclear Energy On The Sidelines
UK Chancellor Hammond Hopes for Hinkley Reactor Decision Soon
South African Energy Plan Stalls On Cost Of Nuclear
UK's New Premier Axes Department Of Energy And Climate Change
Political Pressure on EU Countries Using Russian Nuclear Fuel Mounting
Work On Russian-Assisted Nuclear Plant In Vietnam To Begin In 2023
Czech Nuclear Waste Deep Storage Will Only Be Sited Where There Is Local Support
China Media Again Touts Plans To Float Nuclear Reactors In Disputed South China Sea
China Signals Room For Negotiation On India's Nuclear Suppliers Group Entry Bid
Former Japan Nuclear Regulator Lashes Out Over Earthquake Standards
Work On Russian-Assisted Nuclear Plant In Vietnam To Begin In 2023
EU May Sanction Constructor Of Hungary's New Nuclear Reactors
Rosatom To Work In Crimea Despite Risk Of Western Sanctions
The Fate Of Bulgaria's Belene Nuclear Plant Is Once More Up For Discussion
Hungary Shuts Reactor At Paks Nuclear Plant Due To Malfunction
UK Regulators Provide Update On Reactor Design Assessments
Taiwan's First Nuclear Plant To Retire On Schedule
Czechs May Lift Ban On Deliveries To Iranian Nuclear Plant
French Parliament: EDF Can Support Hinkley Point Financial Risk
Kepco Says It Will Appeal Latest Takahama Court Ruling 'Without Delay'
JAPC To Support Hitachi in UK Nuclear Plant Projects
More Countries Considering Nuclear Energy
Pictures Show Untouched Fukushima 'Exclusion Zone'
New Nuclear Reactor Builds Fall To Zero In H1 2016
Polish Nuclear Capacity Will Not Be Built Before 2030
Iran Says Has Agreed With France To Join Nuclear Fusion Project
Booming Nuclear Industry Creating Opportunities In The UK
Germany Says Forces In Iran Trying To Torpedo Nuclear Deal
Japan Court Upholds Reactor Shutdown In New Blow To Nuclear Industry
The Spanish Nuclear Industry Showcases Its Capabilities In Tokyo
Brexit Political Chaos Matters More For EDF Than Sterling Slump
Japan Elections: Antinuclear Candidate's Win Poses Risk to Plant Restarts
Bulgaria Does Not Rule Out Revival of Ditched Nuclear Project
Russia Offers India Nuclear Aircraft Carrier
Russia and Bolivia Strengthen Nuclear Training And Public Acceptance
Who Will Pay For Decommissioning The Fukushima Reactors?
Is Nuclear Storage In South Australia A Growing Prospect?
Germany Votes To Abandon Most Green Energy Subsidies
Accepting Applications: First Nuclear Energy Management School in Russia
Japan Teaches UAE Lessons Learnt From Fukushima
India's Kudankulam-II Nuclear Plant Will Go Critical On Sunday
Rosatom Completes Engineering Surveys At Paks Nuclear Plant In Hungary
Tougher Safety Rules Fail To Win Over Nuclear-Wary Japan
Bulgaria Secures $80 Million Waste Facility Deal
Georgia: Nuclear Smuggling Cases Raise Concern
Germany Puts Brake on Renewable Energy Expansion
South Korea, France To Discuss Nuclear Energy Cooperation
Brexit Pushes UK Energy Prices Towards Nine-Month Highs
France Submits Fresh Plan For Six Nuclear Plants In Jaitapur
German Agency Accuses Iran Of Trying To Buy Nuclear Technology After 2015 Deal
India Poised To Ramp Up Nuclear Energy Sector
Brazil Police Arrest 19 In Eletrobras Nuclear-Plant Bribe Probe
U3O8 Corp- MOU Signed For Argentina Nuclear Plant Construction
UK Energy Minister Underscores Importance Of Nuclear Energy
Ukraine's Energoatom Restarts Payments To Russia's TVEL For Fresh Nuclear Fuel
South Korea Has High Hopes for Nuclear Energy's Future and Plans to Build 9 New Reactors
Germany To Dump Nuclear Waste For Good - But Where?
Gearing up to Uranium Mining, Botswana Establishes Environmental Radioactivity Monitoring
Thailand Ponders Nuclear Energy With China
Russia Inc Sees Future In New VVER-1200
Germany May Wait 100 Years For Nuclear Waste Storage Site
German Repository Commission Submits Final Report
Russia, Cuba to Sign Deal on Peaceful Use of Nuclear Energy
China's Haiyang Unit 1 Completes CHT, While Fuqing And Fangchenggang Units Reach Milestones
Three New Chinese Nuclear Units Approach Operation
Report: Pacific Ocean Radiation Rapidly Returning To Normal After Fukushima
Thailand Ponders Nuclear Energy With China
IAEA Team Applauds Poland's Progress With Nuclear Program
Jordan Eager for 'Nuclear Cooperation Deal' With US
Hinkley Point 'Litmus Test' On Post-Brexit Investment In Big Infrastructure Projects
Tests Carried Out At UAE Nuclear Plant Barakah
Europe Lags In Nuclear Energy Development
Ikata-3 Fuel Loading Completed, with Commercial Operation to Resume in August
Swedish Regulator Endorses Repository Plans
Nuclear Power Corporation Of India Gets India's First Nuclear Insurance Policy
Russians Hail Latest Nuclear-Powered Icebreaker and Claim Arctic Dominance
Japan, Kazakhstan To Share Nuclear Technology, Resources
China and Argentina Reaffirm Reactor Agreement
Russia's REMIX Nuclear Fuel Enters First Field Trials
Who Pays For Germany's Nuclear Phase-Out?
British Unions Call For Prompt Green Light On Hinkley Point
China's Idled Wind Farms May Spell Trouble for Renewable Energy
German Energiewoopsie, Or, What Happens When You Dump Nuclear Energy
As Japan Re-Embraces Nuclear Energy, Safety Warnings Persist
UAE's Barakah Nuclear Plant Is 65% Complete
Trade Unions Press EDF To Delay Hinkley Point C Decision
Will China Bring Nuclear Energy to Moldova?
Russia Says Work On Akkuyu Nuclear Plant In Turkey Should Be Unfrozen
Japan's Shikoku Electric Looks To Fire Up MOX-Fueled Ehime Reactor Around Aug. 25
Turkey and China Sign Deal On Nuclear Cooperation
India Should Leverage Its Domestic Nuclear Market to Soften China on NSG Membership
Swedish Regulator Approves Repository Application
Brexit's Impact Stretches From Deep Space To Nuclear Fusion
UK's Bradwell's Deep Clean - A First For Magnox
China Repays Credit for Tianwan Nuclear Plant to Russia
US, Mexico, Canada Pledge 50% Renewables And Nuclear By 2025 In New Climate Pact
Political Sniping Follows India's Failure to Win Nuclear Suppliers Group Membership
IEA Chief Fatih Birol Warns About Challenges Facing Nuclear
India Rules Out GE Hitachi Reactors Lacking Working Plant Elsewhere
Economy Minister: France Nuclear Energy Investments Continuing
CEZ Seeks Compensation For Unplanned Czech Nuclear Plant Shutdowns
Russia's Nuclear Energy Expansion – A Geopolitical Footprint?
France Tells EDF to Switch On UK Nuclear-Power Project Despite Brexit
Japanese High Court Denies Injunction Against MOX Fuel Use At Nuclear Plant
UK's NIA Comments On The Vote To Leave The EU
Jordan, Saudi Arabia To Cooperate On Nuclear Energy
China Suggests Nuclear Club NSG May Not Open For India Later This Year
Japanese Court Denies Injunction Against MOX Fuel Use In Saga Reactor
German Atomic Forum President: Do Not Follow Germany Down Phaseout Path
Rosatom's Global Nuclear Ambition Cramped By Kremlin Politics
India Irked By China Stalling Its Nuclear Group Membership
Tepco to Abandon Second Robot Inside Fukushima Reactor


text:
Top Definition
an rising youtube star who has no life and yet make people laught and love him. he hates haters and yet that makes him a hater right?. for the first videos he made he had a mask on witch the story of gedude is that he is a satan spawn and was sent here to intertain us witch he is doing for sure even doe he acts like a pot head (btw he supports weed a lot) he will be making us laught for a long time.oh p.s. here is his face he made for his many web pages he has under his famous name *.*
fred shane dawson makemebad35 icp metal head gedude
by sid sips July 27, 2010
Trending Now


text:
OSI-Approved Open Source (64)
- GNU General Public License version 2.0 (23)
- Apache License V2.0 (16)
- GNU Library or Lesser General Public License version 2.0 (10)
- BSD License (6)
- Apache Software License (4)
- Affero GNU Public License (2)
- MIT License (2)
- Mozilla Public License 1.0 (2)
- Academic Free License (1)
- Artistic License (1)
- Common Development and Distribution License (1)
- Common Public License 1.0 (1)
- GNU General Public License version 3.0 (1)
- GNU Library or Lesser General Public License version 3.0 (1)
- Mozilla Public License 1.1 (1)
- Other License (2)
- Windows (63)
- Linux (61)
- Mac (55)
- Grouping and Descriptive Categories (49)
- Android (19)
- Modern (6)
Frameworks Software
Hot topics in Frameworks Softwarejava ext js 4.2.3 java project with source code asset management java shopping cart pulse drag and drop form builder e learning system using java iec 61499 hand gesture recognition
WebHarvest - web data extraction tool
Web data extraction (web data mining, web scraping) tool. It leverages well proved XML and text processing techologies in order to easely extract useful data from arbitrary web pages.169 weekly downloads
pulse - Java web app framework / CMS
Built for enterprise level and highly customized websites39 weekly downloads
eLML - eLesson Markup Language
eLML (eLesson Markup Language) is an XML framework for creating structured eLessons based on a pedagogical model. eLML consists of an XMLSchema and XSLT files to create XHTML, PDF, LaTeX, IMS CP and SCORM versions, standards supported by most LMS.6 weekly downloads
Toolkit for rapid XML and web application development3 weekly downloads
FOXopen is a 4GL, feature-rich XML framework which facilitates the rapid development of web-based applications with sophisticated workflows. For more information and help, see http://www.foxopen.net/17 weekly downloads
"Yet Another Do-It-Yourself (Test) Automation Framework" specification. Use or modify one of the existing software implementations (hosted/referenced here), or implement the framework yourself. Download and read the spec for more details.3 weekly downloads
iGesture - Gesture Recognition Framework
iGesture is a Java-based gesture recognition framework providing access to multiple gesture recognition algorithms and different input devices. The iGesture Workbench supports the definition and evaluation of customised gesture sets and algorithms.3 weekly downloads
OOONEIDA - FBench
The FBench is the ongoing development of an open-source graphical software tool for embedded automation components and systems based on the IEC 61499 standard. The project originates from the OOONEIDA Workbench pioneered by Dr. James Christensen in 2005.5 weekly downloads
xWire Framework
The xWire framework is a toolkit used to build Java web applications, but is flexible enough for other uses. It is ideal for building AJAX apps and consists of both client and server components, each of which can be used independently of the other.4 weekly downloads
Lemansys LEWS
Lemansys LEWS Alternative Framework for Java Web Applications2 weekly downloads
OpenJean is a cross-platform, extensible, personal information manager. It includes: file manager, RSS aggregator, calendar and appointments diary, mailer, image manager, multimedia manager, favorites, notes, tasks, anniversaries, topics and address book2 weekly downloads
FROG is revolutionary tool used to externalize application properties for WebLogic. It manages properties files in a centralized location(Admin server). It supports dynamic loading of files in fully clustered environment.FROG is platform independent.3 weekly downloads
WebWindows is a framework to develop windows in java web application.3 weekly downloads
ePlatform, developed by Logica, is a framework to enable fast and flexible application development and management, with a focus on case management and application integration. It offers concrete functionality for generic administrative case management3 weekly downloads
Biological Modeling Framework
An ontology-centered framework within the Semantic Web infrastructure that aims at standardizing various knowledge involved in the biological modeling processes. Three biological cases have been developed to evaluate the implementation of this framework.1 weekly downloads
TXS : Tiny XML Server
TXS provides a basic HTTP server. Its own XML Script language can produce, via XSL-T, XForms or XHTML pages (tested with FireFox). It can also be used to read and generate CSV, XML or ZIP files. HTML page capture and email generation also available.2 weekly downloads
A framework for creating CRUD based applications utilizing MDA, and a very pluggable architechure. eg: 2-tear / 3-tear. Web based / Rich Swing Client.1 weekly downloads
HTMLi - 100% XSL AJAX Framework
HTMLi (HTML improved) is the AJAX framework that focuses in: * Transparent use for HTML designers * Multi-platform: 100% XSL (runs with Java, ASP, PHP, etc) * CSS Themes * Multi-Language * XML Handling - AJAX forms Live demo at http://www.htmli.com1 weekly downloads
A simple Java API to get SQL statements from XML files. It enables you to easily separate SQL queries from java code.1 weekly downloads
LOMS - Local Mobile Services
http://www.loms-itea.org The goal of the LOMS project is to define and develop an open service architecture through which new innovative local mobile services can easily be created, deployed, and consumed by mobile users.1 weekly downloads
Lucidium Application Platform
Get your database online quickly using configuration not code. Use this secure, scalable and proven enterprise technology to publish any relational data, any custom process on the internet. MySQL, Java, XML, XSL. xHTML GUI, beta voiceXML and WML/WAP.1 weekly downloads
OpenVend is a leight weight Java Open Source framework to build servlet and portlet web applications with XML technologies.1 weekly downloads
SecFlow - Secure Flow Analyzation for Java and .NET1 weekly downloads
Content adaptation platform that adapts internet content to any mobile device in real time. Includes features such as device detection, image transcoding, DOM manipulation, XML/RSS feed support and much more.1 weekly downloads
SmartWave LDAP Persistence framework
SmartWave LDAP Persistence is an object to LDAP mapping tool for Java, which provides you with an easy-to-use LDAP persistence layer.1 weekly downloads


text:
Clinical-Style Validation, Regulation, and Quality Control...
Keep the Opportunities, Lose the Opportunists
Researchers Now Have a Myriad of...
Co-Sourcing Improves Pharmaceutical Laboratory Productivity
Karo Bio entered into a research collaboration agreement with Pfizer in the field of autoimmune diseases. Karo Bio may receive up to $217 million in up-front and milestone payments in addition to royalty fees.
The focus will be on small molecule RORgamma modulators. Pfizer will provide full funding for research costs. It has the exclusive right to market any products that may be developed as a result of the collaboration.
The nuclear hormone receptor RORgamma is a new target for the treatment of autoimmune diseases like rheumatoid arthritis and psoriasis. RORgamma directly controls the production and secretion of the cytokine IL-17, a major contributor to inflammation. The receptor's key role in driving disease pathology has been implicated through clinical studies using mAbs that neutralize IL-17 activity.
"The central role of RORgt in Th17 cell differentiation coupled with the increasing clinical validation for the importance of IL-17 and other Th17-derived cytokines in autoimmune diseases makes RORgt a compelling target," says Jose-Carlos Gutierrez-Ramos, svp, biotherapeutics, worldwide R&D, Pfizer. "Combining KaroBio's deep expertise in nuclear hormone receptors with the world-class chemistry and cytokine immunology expertise of Pfizer has the potential to accelerate our drug discovery effort in this competitive area."
Karo Bio's projects focus on nuclear receptors as target proteins for the development of new pharmaceuticals. It says that it has two in-house projects in clinical development phase, one in preclinical development, and one in early discovery phase. The company also has partnered programs with Merck & Co. in women's health and multiple scleroris, Alkerm in dyslipidemia, and Zydus Cadila in inflammatory diseases.
Additionally it has a separate agreement with Pfizer, which began in 2001 with Pfizer's now wholly owned subsidiary Wyeth. It focuses on the development of new drugs for the treatment of inflammatory diseases with the liver X receptor as a target protein. From September 2009, Wyeth took on full responsibility for R&D.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today's life science tools and technologies.
You're all set! Thank you for subscribing to GEN Highlights.
MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
Quick Details
- Type: Utensils, Pie and Cake Lifter
- Utensils Type: Spatulas
- Material: Plastic, PS
- Plastic Type: PS
- Certification: CE / EU, FDA, LFGB, SGS
- Feature: Eco-Friendly
- Place of Origin: Jiangsu, China (Mainland)
- Brand Name: WUXI TOPTEAM
- Model Number: TM-8001
- Color: Pantone Color
- Size: 9.5 inch
- Weight: 18g
- Packing: 48pcs/inner, 24 inners/ctn
- CTN Size: 60*54*56cm
Packaging & Delivery
|Packaging Details:
|48pcs/inner, 24 inners/ctn
Welcome to Wuxi Topteam Co., Ltd.
Established in 2003, Wuxi Topteam is a leading manufacturer and exporter offering a comprehensive assortment of plastic party and catering tableware including drinkinware and serveware such as glasses, tumblers, trays, bowls, pitchers and utensils etc., a decade of experience in the industry enables us to understand what customers want.
disposable heavy duty plastic pie and cake lifter
|Item No.
|Delivery Time
|25~35 day
| L/C or T/T
Product details
1) Item No.: TM-8001
2) Product Name: disposable heavy duty plastic pie and cake lifter
3) Size:9.5''
4) Material: PS
5) Color: Can be customized
6) Certification: FDA, SGS, LFGB
7) Usage: Suitable for party, bar, banquet, home and food industry
Product photos
Product range (click to choose)
Plastic Tableware Accessories
Plastic Serving Utensils
Plastic Pitchers
Plastic Bowls
Plastic Trays
Plastic Drinkwares
Bio Box
Ice Cream Cups, Lids
Soup Cups, Lids
Metal Can Lid Making Machine
Company information
About us
Canton Fair


text:
No products in the cart.
Buy Showroom Stock @ Great Prices
Teak Sofa Sets ( 3 + 1 +1 ) @ 25% Off
Teak Arm chairs @ 25% Off
Teak Sofa Beds Without Storage @ 15% Off
Teak Sofa Beds With Storage @ 15% Off
Sectional Sofas @ 20% Off
Teak Beds
Teak Large Wardrobes
Chest of Drawer
Bedroom Sets
Bar Cabinets
TV Cabinets
We got prompt delivery & genuine teakwood furniture from bic. Definitely a trustworthy furniture brand.Vishwanath Ramaswamy - Power Systems Country Leader India & South Asia IBM India
I purchased a dining set from bic & am very happy with the quality of wood & finish. Will Surely buy from them again.Arif Zakaria Actor
We furnished our conference room with tables made by bic. The design details, quality standards were followed exactly the way we wanted. We were extremely satisfied with their product & serviceDBS Business centre
"It was a pleasure working with BIC as they were willing to make customizations for us. There are several online stores for furniture, but customizations are not possible. The furniture from BIC has been delivered and we are extremely happy with the quality of teak wood and work. The overall experience was very good. Would highly recommend BIC".Vinay -Software Architect Intel
As Featured On
Less Space?
Let Us Help You Plan Your Furniture
Get customized wooden furniture solutions for your bedroom & living room in your choice of wood, be in teak wood , sheesham wood or plywood. Our furniture range caters from wardrobes & beds to bar units or any individual storage pieces that may be required for your home.
An exclusive home furniture store where every single piece of wooden furniture is crafted with passion and care. We believe that every home is special and that every piece of furniture in it should be that way too. Our specialty lies in bringing to you traditional and contemporary furniture that is classy and chic. .
We like our furniture to be impactful, but in a very subtle way! Of special note are the complete teakwood sofa sets that are exclusively available with Bic in Mumbai. These may be made in teakwood. Both these wood species have very distinctive grains, are strong, durable, and are perfect for our exquisite creations.
These sofa sets can easily become the focal point of any living room and can be used as accent pieces as well. Also on offer is an impressive array of bedroom furniture, dining sets, sofa sets, TV cabinets and standalone wooden furniture pieces that will complement your good taste and add the attraction quotient to your home.
You are sure to find something in our store that matches your style, but if you don't, we are more than happy to customize furniture for you. Wooden furniture is our passion and we know that you are passionate about designing your home too. With this in view, we perfectly accent pieces that will also fit in beautifully and complete your home.
Prices include VAT | One year manufacturing warranty* | Ready Stock


text:
Skip to comments.Judge allows civil suit over co-worker's perfume
Posted on 11/28/2008 3:50:26 PM PST by Oyarsa
DETROITA federal judge says a Detroit city employee can proceed with a civil suit claiming she couldn't work because of a co-worker's strong perfume. The Detroit News says U.S. District Judge Lawrence Zatkoff determined Susan McBride has a potential claim under the Americans with Disabilities Act.
The city is asking to have the suit dismissed.
McBride says she's severely sensitive to perfumes and other cosmetics. She says the perfume worn by a co-worker in the city's Planning Department made it difficult for her to breathe.
She says the co-worker also used a plugged in room deodorizer.
The suit says the co-worker later agreed to stop using the room deodorizer but kept using perfume.
(Excerpt) Read more at denverpost.com ...
Shes right, some people irritate with lots of perfume.
>Shes right, some people irritate with lots of perfume.
My nose doesn't like that either... of course it's a lot more tollerable outside with a slight breeze and proper positioning.
Some people slather on the perfume in the morning so it will be just the right lingering scent by evening. It is hard on coworkers. I had a friend who had to leave rooms where perfume was evident because it caused her raging headaches.
I get a migraine triggered by perfume and cologne. My day gets ruined, and the meds cost $20/pill. Most people will respect my requests.
If not, I would be more than happy to inflict an equal amount of pain on the culprit.
Those plug-ins with the harsh chemicals are REALLY irritating.
I assume she went to corporate real estate and asked for a different cube and was denied.
>I assume she went to corporate real estate and asked for a different cube and was denied.
Maybe, or maybe she was slapped down hard by the coworker [or her supervisor] when she brought it up.
..........she's severely sensitive to perfumes and other cosmetics.
Long before smoking bans, I'd take my cigars outside before I'd light up, out of courtesy. Had a co-worker who would drench in horrible perfume. Could smell em before they even turned into the hallway. Would come into my office and I'd have tears in my eyes for an hour. After asking kindly a half dozen times to tone down the amount, I took a different approach.
Each time the person left my office, I'd go down to their's and light up.
They got the hint after a few times. Geez, I could'a sued, instead.
Come on! It's "aroma therapy!"
Actually, I hate that stuff. Makes me cough. Either the people that wear that much perfume, have dead senses of smell, or stink!
At the same time I and many of your coworkers get blinding headaches by 10:30 AM that lead us to engage in violent bat swinging rages if we don't get our morning coffee.
Do you care to risk that?
Even someone posting about coffee gives me headache so please stop umm-K?
I'm amazed at where the consensus seems headed with this. As with smokers, perfumy ladies' personal freedom ends at the very first discomfited nostril?
Anyone using that much deoderizer and perfume, makes you wonder what kind of stink they are trying to cover up. I used to work with a woman that wore too much of a strong perfume and you could smell her coming about 40 ft away. I asked one time what type of perfume she wore and she said it was Avon. Figures.
Welcome to the U.S.A of today: "The Republic of ME".
I think you should have to go outside and drink it. I also think that Starbucks should stop selling coffee so I can go inside their stores. :)
I do hope everybody knows I'm kidding. Not about the smell of coffee making me sick but that I think everybody should cater to me. I have learned to deal with it and it's my problem not anybody elses.
The only time I really wish I could stop someone is when I'm doing some exercise classes. There's this one teacher who believe it or not drinks coffee during the class. She always sits her coffee right near me and it really gives me a giant headache. I suppose I could just stop doing the class, which I have thought about. Oh well, such is life.
I am extremely allergic to any kind of strong smell. I was in the grocery store today and was going to buy clothes detergent but every one I picked up had some kind of perfume smell to it. I just can not be around that stuff. And, some people think that a whole bottle of perfume is necessary before going out. I remember a lady at church who wore a lot, bless her heart. I knew it was her coming in the door without turning around. I was at least 75 feet from the door. It did not bother me when I was younger but now I have to stay away from it.
We have a rule in choir that no perfume is allowed due to so many of us being allergic to that stuff.
If you were as allergic to that junk as some of us, you would not be joking about it. I have been sick for weeks after being around someone who did not know that just a little works not the whole bottle and most times, that little is too much.
I am retired, but if I were still working and if you were working in my office, and if you would have complained about my coffee... I would have killed you. ;>)
Not joking about it all. It makes me quit sick as I have stated. I just don't think I have the right to tell other people how to live because it makes me sick. Stay home if you don't like it.
Some perfume smells so good they ought to pay people to use it.
That stuff makes me sick. I've had my throat close up and even trace amounts give me headaches.
Fortunately, I'm a software engineer and don't have many women in the office.
This is her job. How hard would it be for the other woman to tone down the perfume? I know I would if my perfume was causing someone else distress.
Perhaps we could include the geat "[un]washed" who's body odors are offensive to the extreme to my very sensitive nose and no doubt is the cause of my present, physical condition--whatever that might be?
I would imagine these cosmetic companies also have deep pockets and there must be some bottom-feeding, shysters (I UNDERSTAND JOHN-BOY IS PRESENTLY UNEMPLOYED)who would take up this righteous cause?
I wonder how many premature deaths can be [in]directly attributed to this condition?
Someone, notify the EPA,and the CDC, stat!!!
But sooner or later they discover the downside....it attracts a lot of "rump rangers".
Well, it is not allowed in my choir since so many of us are allergic to it. You can walk away from a coffee pot if it bothers you but if you are in a very small room with 100 singers and half are coughing their heads off, runny noses, etc. then people should not wear it. Ladies can do without wearing perfume 2 times a week, one at practice and once on Sunday. But, when a lady wears so much perfume that I knew when she walked in the door and I was at least 75 feet away, then that is way too much. My late daughter use to have a friend who stayed with us a lot when they were in high school. I did not even have to know that she had been here but as soon as I walked in the house, I knew she had been here due to her perfume. That is way too much that it lingers for hours after a person has left the house. Why should those of us have to stay home due to the inconsideration of a few who have lost their sense of smell?
People may be annoyed....but not incapacitated...
Sounds like a setup. Wonder what else is in her background.
I use to love to wear perfume. In fact, White Shoulders was my very favorite. But as I grew older, the more allergic I am to it. I can be sick for weeks just from going down the candle aisle at a store. I have no idea why I grew allergic to it over the years but lots of people I have talked with about it have said the same thing. It did not bother them when they were younger but it does now. When we are having choir practice, people will stop practice to remind people not to wear perfume. It is not good for singers as well as others to have throat and ear problems due to a smell that is not necessary all of the time.
Just an offhand observation, but that it a curiously appropriate screen name for this particular thread.
How long have you been waiting for a chance to use it, Mr. Acetonitrile?
"The smell of coffee makes me nauseous and gives me headaches. I think people should quit drinking coffee just for me. "
This is no trivial matter. Did you have trouble understanding what Oyarsa wrote? I have the same issue.
I get migraines as well as cluster headaches.These headaches actually drive people to suicide. Perfume triggers them in me the same as they trigger migraines in others. The treatment is the same $20+ pill (if I can catch it fast enough) or a $75+ injection if I don't.
This isn't just something unpleasant, it is something that actually causes medical issues with people.
I'm down with that. I started deleting man-made fragrances from my life 30 years ago, and over time I became extremely sensitive to them.
When people are inundated daily with strong, un-natural odors, they become de-sensitized to them over time.
Removing oneself from such an environment restores a person's normal level of olfactory perception.
Therefore, when a person is again exposed to those same odors, in the same concentrations, they can be overwhelmed to the point of serious discomfort, or even disability.
I've experienced it myself. It's gotten to the point where if I have to hold my breath on the detergent aisle in the grocery store, the fragrances are so pungent.
Take the space out. Will do a bit more than take off the old nail polish.
Take the space out?
You are told how to dress, when you can eat, what you can drink, what you can listen to, who you must sit by and what you can do.
You accept payment to give up these freedoms.
If your actions, appearance or aroma makes other workers uncomfortable then they have the right to make that known and the boss has the right to tell you to knock it off.
Yeah, CH3CN. Not CH3 CN.
Perfumed candles also give me a problem, but if the weather is warm, and my allergies are not in sensitivity mode, I can burn the scented ones.
Also, sometimes allergies do manifest themselves later in life. I used to never have a problem around cats until the last 25 years, (I am now 60)and now I know if there's a cat in the house without ever having seen the cat. My throat starts tickling, and my eyes begin itching and watering.
Well, I am irritated by the horrendous body odor of the hippies who live in my area who don't bathe, use deodorant, and have stinky dreadlocks.
I live in No. California by the way.
To me they smell worse than any perfume.
I don't think I can do anything about my hippie liberal problem.
I wear perfume, not a lot of it, just one spray. I wouldn't stop wearing it just because someone asks me to.
Now if there is a very serious medical issue that is proven, I might stop, but otherwise no.
Why do we have to keep fighting for our individual rights?
Yes, some perfumes are lovely. That's the kind I wear. I am always complimented on my perfume. One time while visiting Minnesota (from Canada) a young lady in Penske's asked me about it. She was so disappointed to find out she could not buy it in the US. When I got back home I sent her some. She emailed me when she ran out and I sent her some more. It was quite fun - she was so sweet and had the same name as my daughter.
OOOps, #40 was for you. The aroma might about as unpleasant, though.
first they came for the tobacco smells..........
Nanny State Ping.
This was only a matter of time folks. I can't stand heavy perfumes, and have had allergic reactions to some, but the idea of going to court over such just never crossed my mind, nor would it even though I've been seeing it happen more and more frequently.
It can be incapacitating. Allergies can lead to asthma attacks, and while I'm not allergic, it's a migraine trigger. If people were remotely considerate, it wouldn't be a big deal.
Believe me, it's tough to ask, and I've only had one person make a big deal about it.
My life can be very painful and I wish it was different, but it is what it is.
I knew a guy who had to work in the same area as a woman who wore heavy doses of industrial strength cheap perfume. He had problems with his wife who could smell it on him when he went home.
What would you accept as proof?
Give me a smoker over a perfume wearer, any day.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
On our recent trip around Japan we had to brake our trip in Nagoya to fit in with the train schedules. I had some Hilton Hhonors points to use up, so booked a night at the Hilton, despite looking first for a hotel nearer the station.
I am really glad we chose the Hilton - we have never had such a warm greeting and excellent service in a large chain hotel anywhere in the world. First off a porter rushed over to take our bags as soon as we had entered the hotel's forecourt. Then at the front desk we were told that we had been upgraded to an executive floor (I am hhonors gold) and so were ushered up to the executive lounge on the 26th floor to complete checkin. Everybody seemed so pleased to see us.
We had a deluxe room on the 24th floor which was very well furnished with nice Japanese touches like yukatas and sliding paper screens for the windows instead of curtains.
We had evening cocktails with appetisers in the lounge and breakfast the following morning. At each the food was very good and the service impeccable, even though my wife's cocktail order (black Russian please) did stretch the lounge staff's English somewhat.
The next time we are in Japan, I would consider booking two nights at the Hilton and taking more time to see what Nagoya has to offer.
- Official Description (provided by the hotel):
- Just 5 minutes from Nagoya's main station in the heart of the business, shopping and entertainment area in Nagoya, the Hilton Nagoya is the city's only international full service hotel providing world class accommodation, banquet and restaurant facilities in the city center. The hotel is close to the world's largest planetarium of Nagoya City Science Museum and provides a complimentary shuttle service to nearby attractions such as Nagoya Castle and Nagoya station. Guest rooms feature modern interiors, all contemporary comforts with dynamic city view including the most refreshing, restful bed, LCD TV with entertainment channels and high speed internet access. A full range of branded quality amenities, as well as comfortable bathrobes, Japanesse Yukata and slippers are offered in all guest rooms. The hotel offers 16 banquet rooms, with wireless internet access. Swim in the 49-foot indoor pool or work out in the 24/7 gym and relax in the sauna. Choose from 6 restaurants and bars at this Nagoya hotel and do business in the Executive Lounge or one of 16 banquet rooms for 10 -1200. Nagoya, Japan's one of the largest city makes a great base for exploring central Japan, beginning with the highlights of Nagoya's cultural and industrial heritage, excellent shopping and entertainment, as well as exploring the Ise Grand Shrine, the World Heritage sites of Shirakawa-go. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Hilton EMEA, Booking.com, Priceline, Hotwire, Rakuten, JAPANiCAN, Travelocity, HotelTravel.com, Agoda, Hotels.com and Odigeo so you can book your Hilton Nagoya reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Hilton Nagoya Hotel Nagoya
- Nagoya Hilton


text:
Sam, is a 6 year old, 45 pound a male red heeler/beagle mix rescued from the animal shelter and seeking his OWN home.
Sam suffers a bit from "little man syndrome" and tries to pick on bigger dogs. Then, he freaks out and gets scared to death if they call his bluff.
Sam is very sweet and craves affection from his person.
Peanut an adorable Chihuahua is 6 years old and weighs 8 pounds. He is very sweet, likes to be a lap dog. He is learning his manners and house training.
Website powered by Network Solutions®


text:
Capturing what matters and measuring what counts: This is a global leadership imperative. And it is the best--if not the only--way to showcase that managing digital globalization and delivering international experiences effectively pay off. It is all about effectiveness and starts with the early steps in the global content value chain. A number of criteria and indicators should be on the radar screen of anyone willing to define, analyze, and leverage effectiveness holistically. Productivity may not always be at the top of the list in terms of localization benefits although it definitely drives time and cost savings, while enabling to better allocate resources and optimize timeframes. It may come up as a secondary factor or be diluted in other prominent indicators such as content accuracy or consistency.
Jun 05, 2007
For the fifth consecutive year, CAS and the hbz consortium, the North-Rhine Westphalia Service Centre for Libraries of Germany's largest state (Hochschulbibliothekszentrum des Landes Nordrhein-Westfalen), have renewed an agreement to provide SciFinder Scholar, an academic research discovery tool, to 57 universities and 8 Bachelor schools in Germany. In addition to providing ongoing access to CAS databases, chemical and related scientific information, SciFinder Scholar will, by this summer, include new options and features of SciFinder 2007 designed to enhance the exploration of CAS' resources.
Among other capabilities, SciFinder Scholar 2007 features will permit researchers to: combine answer sets for substances, reactions and references where researchers will be able to combine answer sets in SciFinder Scholar; explore from substance display where researchers will be able to capture a chemical structure from a substance answer display, then use it to search by structure in the CAS Registry database; print structures in thumbnail display format so that multiple chemical structures can be printed in a grid arrangement for a comparative view; group references based on focused scientific categories. References can be more clearly grouped by similar themes; save SciFinder Answers so that researchers will be able to save search results in a re-usable format allowing them to be re-opened in a later SciFinder Scholar session.


text:
California Democrat Barbara Boxer has put together a new climate change task force in the U-S Senate. The group is focusing more on keeping current regulations in place than in advancing new legislation.
In spite of broad consensus in the scientific community, there remain a lot of climate change skeptics in Congress. Senator Boxer says that's why the new task force is necessary.
"Our goal is to wake up the Congress."
~Senator Barbara Boxer
Boxer recognizes with Republicans in control of the House advancing climate change legislation is next to impossible. But she says the task force will play a vital role in combating attempts to unwind current environmental regulations.
"We know we have to fight back against roll backs. This is a huge issue," she said. "And a few of us have done that alone…we have a task force now that is going to be at the ready because the biggest fight we're going to have is to keep the progress we've already made."
In spite of the makeup of Congress, Boxer says the task force is also focusing on maintaining renewable fuel standards and increasing energy efficiency programs.
Related Stories
Drought Intensifies As Wildfires Grow In Western U.S.Thursday, July 28, 2016
The drought intensified over the last week in the Western U.S. as the region swelters under a heatwave and firefighters battle major wildfires.
New Poll Shows Californians' Opinions On Climate Change, WaterWednesday, July 27, 2016
A new poll shows Californians support the goals of the state's landmark law to reduce greenhouse gas emissions. It also found that Californians want state and local governments to do more when it comes to the drought.
Drought Persists And So Does Water Conservation In SacramentoThursday, July 21, 2016
Mandatory statewide water conservation rules have ended in California. But Sacramento-area users conserved 22 percent in June, compared to June 2013.
Pigeon 'Whisperers' Use Birds To Track Lead PollutionWednesday, July 20, 2016
A UC Davis researcher has used pigeons to track lead pollution in New York City and plans to do the same in California cities and agricultural areas.
Nevada Settles EPA Stormwater ComplaintWednesday, July 13, 2016
The state of Nevada will pay $120,000 to settle a U.S. Environmental Protection Agency complaint about storm water runoff pollution in Reno.


text:
You never what changes are going to come in life. And often, life keeps you so busy that you really do not think much about it, until it is sometimes too late. At some point, I found myself dealing with impotency with my wife, and it really bothered her. It hurt me a lot that it upset her so much. It is not like it is something that I wanted to have happen. She finally told me about crystal x and that I should try it to see if would help my "problem."
I thought it over for awhile, and decided to check into the new product my spouse had told me about. I then decided that I was willing to try it out for the sake of our marriage. I was perfectly happy with just holding hands and hugging as a couple, but that is not what she wanted from me. So, I ordered some. I hoped that it would work for her sake. Continue reading "I Learned Something After I Ordered This New Product"


text:
Passive Wireless Corrosion-Monitoring Tags
Award Information
Small Business Information
EngeniusMicro, LLC
1718 Peachtree Street, Suite 390, Atlanta, GA, -
Principal Investigator:
Brian English
(404) 382-1260
(404) 382-1260
Business Contact:
Larry Heaton
VP Operations
(404) 382-9646
VP Operations
(404) 382-9646
Research Institution:
Georgia Institute of Technology
Mark G Allen
791 Atlantic Drive
Atlanta, GA, 30332-
(404) 894-9419
Nonprofit college or university
Mark G Allen
791 Atlantic Drive
Atlanta, GA, 30332-
(404) 894-9419
Nonprofit college or university
AbstractEngeniusMicro and the Georgia Institute of Technology propose a passive wireless sensor platform for the monitoring of corrosion on aircraft and for stored aircraft components. Multiple volumes, chambers, and compartments within aircraft are susceptible to corrosion damage because they are exposed to moisture, they trap heat, and they are difficult to inspect. Placing passive wireless corrosion sensors in these areas would enable maintenance technicians to quickly assess the corrosive potential, or level of actual corrosion over the lifetime of the asset. The passive sensor would be scanned by an external reader and would indicate that the corrosivity within the chamber has increased or reached a critical value. Ideally, this reading could be taken without opening the chamber. This would decrease inspection time, increase inspection coverage, and enable inspections more often while yielding historical quantitative data as to structure corrosion. These sensors could also be integrated into prognosis models that allow predictive maintenance actions as part of the aircraft"s health monitoring system. EngeniusMicro will develop these sensors with fabrication support and design from Georgia Institute of Technology.
* information listed above is at the time of submission.
An Official Website of the United States Government


text:
Exceptional, without exception
Cromer Academy is a thriving secondary school in north Norfolk.
Our vision is that every student feels a sense of personal achievement and is motivated and equipped to pursue their goals and dreams.
We aspire to be exceptional in all we do, and find the things that make each member of our community exceptional, and celebrate them.
Dr Geoff Baker, Principal
Latest News
Cromer teacher wins social enterprise award
Cromer Academy teacher Mrs Harper has won the 2016 Best New Teacher award from social enterprise Inspired Youth.
Cromer Academy to host RNLI fundraiser
Enjoy good food and live music for a good cause, at Cromer Academys three-course charity meal later this month.
Schools come together for special Christmas concert
More than 200 pupils from Inspiration Trust schools have performed at a special Christmas concert at Norwich Cathedral.
Free GCSE weekend workshops
GCSE students can boost their skills at free weekend workshops this month.
Food project wins awards
Cromer Academy's Food To Fork project has been recognised with a Bernard Matthews Youth Award.
Our October newsletter
Catch up with the latest news from Cromer in our October newsletter.
Twitter feed
New displays for the new term...@CromerAcademy #lookinggood https://t.co/Ls0PIFz35o
Wed 27 July, 4:11pm
Award winning @kirstyharper4 develops new careers resources for @CromerAcademy. #careerseducation so important https://t.co/xrShQI6ZFK
Wed 27 July, 3:01pm
Farewell @CromerAcademy massive old shed. You have served us well but sadly the time came to say so long. #shed https://t.co/LyCR1yKXg9
Wed 27 July, 2:46pm


text:
UVic news
Check here for the latest news about UVic or follow @uvicnews on Twitter. If you're looking for more information or a UVic expert for a news story, please call University Communications + Marketing at 250-721-7636, Monday to Friday from 8:30-4:30.
Tiger shark research in Tubbataha
An international research team recently placed a satellite tracking tag on a tiger shark in one of the world's most pristine reefs—Tubbataha Reefs Natural Park—and is now tracking its movements.UVic geographer Phil Dearden assisted this project, led by the Tubbataha Management Office and marine conservation group LAMAVE in the Philippines.
Optical spring detects single molecules
A team of engineering researchers from UVic and the University of Rochester has developed a way to detect single molecules using a light-based technology inspired by the "whispering gallery" effect, first discovered in London's iconic St. Paul's Cathedral.
Expert on aftermath in Turkey
UVic historian Martin Bunton is available to media to discuss the aftermath of the attempted coup in Turkey. He is also the current interim director of UVic's Centre for Global Studies. (Oliver Schmidtke is currently the Acting Associate VP Research for a one-year term.)
UVic astronomers help discover new dwarf planet
An international team of astronomers including UVic researchers has discovered a new dwarf planet orbiting in the disk of small icy worlds beyond Neptune.
- View more news on the UVic communications website.


text:
They have put that i signed fraugulent time cards for jobs that i did after school.I was not paid by hours i was paid one flat amount,
Debt Settlement Attorney
I represent claimants before the Appeals Tribunal of the TDLWD and present appeals to the Commissioner's Designee. On occasion, I represent claimant's in various Chancery Courts on Judicial Review as well.
Jason Barnette
Barnette Law Offices
309 Hollow Tree Court
Nashville, TN 37221
I am not your attorney nor is any answer I may provide legal advice. You may contact me directly for legal advice only if you are a resident of Tennessee insofar as I only practice in Tennessee.
Post a free question on our public forum.Ask a Question
- or -
Search for lawyers by reviews and ratings.Find a Lawyer


text:
Monday following the end of the first of the Democratic National Convention in Philadelphia, Fox News Channel aired an interview network host Sean Hannity conducted with Republican presidential nominee Donald Trump. During the interview, Trump insisted his general election opponent
During CNN's coverage of the first day Democratic National Convention, CNN Political Commentator and former green jobs advisor to President Obama Van Jones argued that "it's hard to say" that presumptive Democratic presidential nominee former Secretary of State Hillary Clinton
During Senator Elizabeth Warren's (D-MA) speech at the Democratic National Committee on Monday, some in the audience started chanting "We trusted you!" after she stated, "I'm with Hillary." Follow Ian Hanchett on Twitter @IanHanchett
During the Monday broadcast of "Around the Horn" on ESPN, Washington Post sports columnist and frequent ESPN panelist Kevin Blackistone reacted to NBA great Michael Jordan's statement regarding the tension between African-Americans and law enforcement. In the statement, Jordan said he donated
Representative Steny Hoyer (D-MD) was greeted with boos from some in the audience when he said, "We're here to nominate Hillary Clinton" during his speech at the Democratic National Convention on Monday. Follow Breitbart.tv on Twitter @BreitbartVideo
During MSNBC's coverage of the Democratic National Convention on Monday, NBC's "Meet the Press" host Chuck Todd said that the convention is "a mess" and worse than the RNC was on the first day. Todd said of the DNC, "[T]his
At the start of the Democratic National Convention, members of the crowd began booing the invocation and chanting "Bernie!" when the leader of the invocation, Rev. Dr. Cynthia Hale, mentioned the name of presumptive Democratic presidential nominee Hillary Clinton. Follow Ian
During CNN's coverage of the Democratic National Convention on Monday, the network cut away from a report on protests outside the convention to show the musical performance by Boyz II Men inside the convention. Follow Breitbart.tv on Twitter @BreitbartVideo
Hundreds of Bernie Sanders supporters took to the streets of Philadelphia to show their disdain for presumptive Democratic presidential nominee Hillary Clinton by chanting while marching, "Hell no, DNC, we won't vote for Hillary!" (h/t Real Clear Politics) Follow Breitbart.tv on
According to NBC's Chuck Todd, it is "insanity" and "stupid" that soon to be former DNC chair Debbie Wasserman Schultz still has a role at the Democratic National Convention following the WikiLeaks emails that revealed favor for presumptive Democratic presidential nominee Hillary
In his first show as co-host of "First Take" on ESPN2, Max Kellerman reacted to a video of what is believed to be the NFL's Aldon Smith smoking marijuana by questioning why it is outlawed in the NFL when alcohol's effects
NBA Hall of Famer Charles Barkley is not known for being good at golf, but he unleashed a new swing that may change that on Sunday at the American Century Championship. At the 155 yard par-3 7th hole, Barkley swung
Monday at a breakfast for the Florida delegation in Philadelphia before the Democratic National Convention officially opened, embattled outgoing Democratic National Committee chairwoman Rep. Debbie Wasserman Schultz (D-FL) was booed by attendees. Wasserman Schultz has been under fire for what
Monday on MSNBC's "Morning Joe," host Joe Scarborough reacted to emails revealed by WikiLeaks from employees of the Democratic National Committee. Some of those emails were critical of the coverage that aired on MSNBC's "Morning Joe" of the race between
John Catsimatidis, host of "The Cats Roundtable" on New York AM 970, asked Republican Party chairman Reince Priebus Sunday why CNN criticized GOP presidential nominee Donald Trump's acceptance speech at the Republican National Convention. According to Priebus, CNN, as well as other


text:
2005 Mazda MPV - Consumer Review
Build Quality
Reliability Value
Build Quality
Reliability Value
1 of 1 people found this review helpful
The Perfect GUV (golf utility vehicle)
By retiredgolfer on
Vehicle2005 Mazda MPV LX 4dr Minivan (3.0L 6cyl 5A)
ReviewI'm retired and the primary use for my vehicle is to take me and my buddies to and from golf. I've had a pickup for years, but decided I wanted something that would keep the clubs/carts inside and have the capability to carry more than 2 golfers in comfort. Tried several different SUV's and smaller station wagons but none had adequate cargo capacity for my needs. Tried some other minivans but they seemed too big or too pricey. Stumbled on the MPV and found it perfect at the right price!
Best FeaturesFlexibility to go from cargo to passenger carrying configuration. Fold down 3rd row seat. Sliding 2nd row bucket seats. Power windows in sliding doors. Decent MPG. Drives like a car, very quiet and smooth.
Worst FeaturesI guess just the location of the shift lever could be moved. Any other improvements would probably add to cost of vehicle and I love the price!
Recommend (1) (0)
Are you the author of this review?Update Your Review
Comments (0) Post a Comment
You must be signed in to post a comment.


text:
In This Section
Journal Forum
A Meta-Analysis of High Resolution Audio Perceptual Evaluation - June 2016
2 comments
Synthetic Reverberator - January 1960
3 comments
Sound Board: High-Resolution Audio - October 2015
4 comments
AES E-Library
Subjective Listening Test of Multichannel Audio Codecs
In 1988, subjective listening tests of popular multichannel audio codecs in the 5.1-channel format were carried out. The systems under test were real time implementations of Dolby AC-3 and MPEG-2 Layer II. The tests were conducted according to recommendations of ITU-R and EBU. A description of test methodology and test design will be given. The results will be presented and discussed.
Click to purchase paper as a non-member or login as an AES member. If your company or school subscribes to the E-Library then switch to the institutional version. If you are not an AES member and would like to subscribe to the E-Library then Join the AES!
This paper costs $33 for non-members and is temporarily free for AES members.
Learn more about the AES E-Library
Start a discussion about this paper!


text:
Hacker group Anonymous is not a new name to the online world. Its not a small group, but its an army of hackers that has penetrated into taking down sites like that of the CIA, US department of state etc. Yesterday, they even managed to divert all traffic away from CBS.com. And today they have come out with a warning video posted this morning on their official YouTube page that they will be targeting taking out or disrupting Facebook's service to its users throughout the world. Here's the video:
The post on the YouTube video states:
Hello. People of the world. We are anonymous. The time has come. An online War has begun between anonymous, the people, and the government of the united states. While SOPA and PIPA may be postponed from congress, this does not guarantee that our internet rights will be upheld. For those unaware, there is still ACTA or the Anti-Counterfeiting Trade Agreement. You. The public. I have a proposal. Would you like to become part of the greatest internet protest and first official cyber war? Anonymous is in the hands of us all. It is time to take action. Operation global blackout is ongoing and everyone can be a part of it. In the description I have provided everything you will need. Our first target… Facebook… While it is true that facebook has at least 60,000 servers… It is still possible to bring it down… Anonymous needs the help of the people… The people who want to take a stand against the government… The people who want to make a difference… This is what we must do… But first… you must ask yourself, are you truly apart of the anonymous consciousness? Do you fully grasp our ideas and understand what we are. If you do… Then one thing is clear… Together… We the people… We anonymous… Can make a change… We've already crashed CBS… Warner Brothers… And FBI sites… Facebook is our next aim… This will be enough to show them indeed that we are not, playing. Now I will give some general instructions on what to do in order to help crash facebook… First… you will need to download the L-O-I-C or, Low Orbit Ion Cannon from the link provided in the description… Once downloaded… Open the program and type in the URL space http://www.facebook.com and hit lock on… It will tell you facebooks ip address. Because there are different servers, there will be more than one ip address that will pop up on different instances, but they will all be similar. Next you will go to the box that says attack options. Change the threads to 1000. Then you will hit the button that says IMMA CHARGIN MAH LAZER… tHIS WILL NOT WORK if everyone does it at random times… This is why… I would like to conduct this operation at exactly 12 A M on January 28th 2012. A five day preparation… That way… We will have a stronger army built up to fight for our rights… Do not fear… There is no way you can get caught… Hundreds of thousands of us citizens and those of the anonymous idea will all be participating… They cannot take down that large of a group… This is your chance… Our chance… The fate of the internet… Rests in your hands… In owr, hands… Government Of The United States… Leaders of the new world order… You have been warned… Operation Global Blackout Part 2, Facebook. Engaged… We are Anonymous. We are Legion. We do not forgive. We do not forget. They should of Expected us…
YOU CAN CHANGE THE THREADS TO 1000 or 10,000 or more!
Furthermore they have threatened to take down sites like United Nations, Xbox Live, U.S. Bank, Twitter, and YouTube also.


text:
Manage Subscriptions
Log Out
Log In
Get Alerts »
Click here for the latest traffic updates, alerts and road conditions.
Dorothy Krysiuk is the traffic reporter for WCVB-TV Channel 5's EyeOpener newscast.
State police are searching for a child who went missing in the area of a Boston beach.
No email address was supplied by
To complete your registration on this site, please supply an address.
Please confirm or modify the email address to which you will have subscription offers sent.
For a more personalized experience, please supply the following optional information.


text:
Atlantic OceanFront Inn, Ocean City (and vicinity)
- Free WiFi and free parking
Main amenities
- 63 guestrooms
- On the beach
- Outdoor pool
- 24-hour front desk
- Coffee/tea in a common area
- Air conditioning
- Daily housekeeping
Feel at home
- Free cribs/infant beds
- Rollaway/extra beds (surcharge)
- Kitchenette
- Stovetop
- Microwave
- Full-sized refrigerator/freezer
What's around
- In Midtown Ocean City
- Roland E. Powell Convention Center (0.6 mi / 1 km)
- Planet Maze (0.7 mi / 1.1 km)
- Maui Golf (0.8 mi / 1.3 km)
- Jolly Roger Amusement Park (1.4 mi / 2.3 km)
- Ember's Island Miniature Golf (1.5 mi / 2.4 km)
Atlantic OceanFront Inn, Ocean City (and vicinity)
Hotel Info: 866-539-8117from $189
- Ocean Patio 2 Queens/Sofa
- Oceanfront King/Queen Suite
- Standard View 2 Queens/Sofa
- Standard Room, 2 Queen Beds, Ocean View
- Standard Room, 2 Queen Beds, Oceanfront
- Suite, 2 Queen Beds, Oceanfront
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 63 rooms
- This hotel is arranged over 5 floors
- 24-hour check-in
- Check-out time is 11 AM
Required at check in
- Credit card deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Children (16 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
Nearby Two Star Ocean City (and vicinity) hotels
In the hotel
- Coffee/tea in a common area
- Outdoor pool
- Fishing on site
- Bicycle rentals nearby
- Golfing nearby
- Parasailing nearby
- 24-hour front desk
- Number of buildings/towers - 1
- Year Built 2005
- Elevator/lift
- Accessible bathroom
- In-room accessibility
In the room
- Air conditioning
- Coffee/tea maker
- Iron/ironing board (on request)
- Pillowtop mattress
- Balcony
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer (on request)
- 32-inch LCD TV
- Satellite TV channels
- Free WiFi
- Free local calls
- Full-sized refrigerator/freezer
- Microwave
- Kitchenette
- Stovetop
- Daily housekeeping
Top Ocean City (and vicinity) hotels
Recently reviewed hotels in Ocean City (and vicinity)
- Sleep Inn and Suites Ocean CityFrom
"Hotel was great! Close to the boardwalk, affordable, great staff and good breakfast!!"Jun 16, 2016
- Cayman Suites HotelFrom
"Our hotel had a great view and the staff was friendly. The rooms were spacious and the maid service was great!"Jun 14, 2016
- AmericInn Lodge & Suites Rehoboth BeachFrom
"clean. quiet. comfortable. had fireplace in room even if we didn't spend time using it. nice layout. definitely going back, even has pet rooms."Jun 14, 2016
- Comfort Suites Ocean CityFrom
"It was great. My only issue was that I booked two rooms and they were no where near eachother, along with problem with our refrigerator not working. The front desk and cleaning…"Jun 14, 2016
Nearby hotels
Atlantic OceanFront Inn, Ocean City (and vicinity)'s small print
Also known as
- Atlantic OceanFront
- Atlantic OceanFront Inn
- Atlantic OceanFront Inn Ocean City
- Atlantic OceanFront Ocean City
- Atlantic Oceanfront Hotel Ocean City
Noise-free guestrooms cannot be guaranteed.
Optional extras
Rollaway beds are available for USD 15 per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text:
Top Stories
- Harry Potter fans rejoice in midnight book release 10:37 PM
- Trump says presidential debates shouldn't compete with NFL 7/30/16
- Messy fun raises funds for pediatric cancer research 7/30/16
- Suspect pleads guilty in fatal stabbing of Sleepy Hollow teen 7/29/16 Crime
- Spectators gather to see corpse flower 7/29/16
- 'Zika is now here': Mosquitoes now spreading virus in US 7/29/16
- Pool donated to help Rockland man with cancer 7/29/16
- Clinton roars against Trump as a hacking distraction arises 7/29/16
- Playland holds 41st annual Day for People with Disabilities 7/29/16
- Hillary Clinton makes history 7/29/16 Full Coverage
- Newburgh hair studio to honor closed salon's gift certificates 7/29/16
- Voucher program helps senior citizens buy produce 7/29/16
- New sex abuse claim filed against Chappaqua teacher 7/28/16 Crime
- Culinary students in White Plains pay it forward 7/28/16
- Robber strikes bank in Wawayanda 7/28/16
- Power restored in Yonkers after crash 7/28/16
Traffic & Weather Center
White Plains, NY
Current Conditions
73° Overcast
Feels Like: 73°
Humidity: 96%
Wind: E 3 mph
7 Day Forecast
Sat 82°
Sun 77°
Mon 79°
Tue 81°
Wed 82°
Thu 84°
Fri 86°
Drive TimesView More Drive Times
advertisement | advertise on News 12
2nd suspect arrested in Mount Kisco jewelry store heist Robber strikes bank in Wawayanda Prosecutors drop all remaining charges in Freddie Gray case
Hooked on Heroin
Pain pill guidelines may help fight heroin Hooked on Heroin: Back to Thiells Police at 12 state colleges to carry Narcan Schumer pushes for more funding to combat heroin use
What's Going On
Patterson Putnam County Wine & Food Fest Sat. 8/6 11 a.m.-6 p.m.; Sun. 8/7 11 a.m.-5 p.m.
- Central Valley Hudson Valley Ride for Kids Sun. 8/7 8 a.m.
- Yonkers Pillars of Perseverance Awareness Concert Sat. 8/6 Noon-7 p.m.
advertisement | advertise on News 12
Social Media
Question of the Day
Who had the better convention?
Weather Extra
Photos of the 2016 Democratic National Convention from Philadelphia. (AFP/Getty Images / PATRICK T. FALLON)


text:
Graphic or Web Designer
This project received 12 bids from talented freelancers with an average bid price of $8 USD / hour.Get free quotes for a project like this
Skills Required
Project Budget$2 - $8 USD / hour
Total Bids12
Project Description
Candidate must be patient and open-minded, understand what is needed to be done just by looking at the materials, willing to do revisions (may be off the clock at times). Have a good command of English Language and adheres to client standards.
Independent contractor preferred.
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
BOOK VALUE IS $11: It won't go below that I think this is the BOTTOM.
Not if they want to be reimbursed by an insurance company.
You have no idea what you are talking about. Doctors use the devices, based on the device, not the economy.
Even medical companies are affected by recession. Medical companies are paid by insurance companies, which are paid by employers. For patients who are covered by MediCare, your assessment might be correct. For all the others, companies will look for ways to skimp on costly benefits, and insurance companies will likewise look for ways to cut costs. You will see more BMS than DES used, cutting into margins, unless it can be clearly shown that the DES is a more cost effective approach within a short period of time. (Think within a year, rather than within 5 years.)
If JNJ and ABT can cut their prices 10% during a recession in order to accommodate insurance companies, BSX will be forced to follow suit in order to maintain their market share. Where is the extra margin available to BSX to make this cut? It has basically already been pledged to make payments on the debt.
Medical companies may do better during a recession than other companies, but if there is growth, it will likely come from the fact that more baby boomers are entering the age where they need some sort of medical care. Insurance companies will still look for ways to cut costs.
Ask the home builders about book value, its a valuable tool but not in a company emploding with horrible management. Book value today is not the book value forever
Does anyone know what the book value was for Celsion?
Had it been maintained at the purchase price of $60 million, or had it already been written down to its sale price of $2.6 million?
Applying the valuation of recent assets for sale to the entire company's assets (2.5 times sales) suggests a share price around 7. Can BSX show enough growth in the remaining assets to justify a higher sales multiple?
No. Here's a better example. The $425 million just raised had revenues of $170 million. That would imply that BSX can sell at 2.5 times revenues. Not great but supports the current price while we wait for growth.
keep try to convince yourself that to make you feel better.
Under Tobin, is not BSX Book Value shrinking fast as we
speak? Assets being sold off. Liabilities? (other than Tobin)
Well we just had $425M hit the balance sheet which is an asset........not bad.......didn't see any talk of a write down!
I wouldn't be so sure. BSX has a way of turning victory into defeat, and defeat into disaster. The same people are running the show, still repeating the same errors. It is an obvious takeover candidate, and the price of relief is getting lower all the time. Just give me 16 now, and it will be over.
cat your glib..........everything sold-off on friday not just BSX EVERYTHING!!!


text:
Ready in 45 minutes
Best pork recipe from J vineyards
0 people want to try | 9 have favorited
?Combine all of the above and marinate overnight
?Preheat BBQ grill to high
?Boil marinade
?Lower grill temp to medium and cook meat for 6 min per side, basting with marinade until it reaches 150 degrees.
?Let meat rest 5 min before slicing
*Serve with leftover boiled marinade as sauce along with brown rice and veggie.
katehandel 6y ago[I made edits to this recipe.]
katehandel 7y ago[I made edits to this recipe.]
blueskier 8y ago[I posted this recipe.]


text:
Via Bryan Hoch, left-handed reliever Pedro Feliciano was advised by Dr. James Andrews to begin a conservative treatment program for his torn shoulder capsule. It's a six-week shoulder strengthening program that Feliciano will begin immediately, and he'll remain with the team throughout the process. Feliciano went to Andrews for a second opinion today, and that he didn't recommend surgery is the first bit of good news the Yankees have received regarding the lefty in quite some time. I guess not all hope is lost for a return this summer.
In praise of the 87.5 mph heat
What can a man do with a mid-80s fastball? Not much, if recent history is any guide. A few pitchers have sat in that range — Jamie Moyer most prominently — but few have experienced success. The hope with Freddy Garcia was that he could get his fastball into the upper 80s. Early in spring training he said that he was effective when his fastball was around 88, but got hit around when it dipped below that. And so it might not have seemed like a good sign that his fastest pitch on Saturday was 87.5 mph.
Yet we know that he pitched as well as he did in any start last season, allowing no runs on just two hits and a walk while facing one of the league's most potent offenses. His fastball averaged just under 86 mph, and he hit that 87.5 speed maybe three times all game. Garcia went to his heat 35 times and generated no swings and misses, yet it still represented his best linear weights score, per Brooks Baseball (just combine the top two rows). Yes, that's 35 fastballs, 24 strikes. He complemented that by mixing in 24 changeups, 16 sliders, 6 curves, and something that PitchFX classified as a splitter. It all made for a nice mix of pitches and speeds.
This is exactly how Garcia will need to approach every start if he's going to succeed for the Yankees. Fastballs in pitchers' counts, off-speed stuff in hitters' counts — overall, a near-random selection of pitches that will keep hitters guessing. That's how Garcia can succeed while throwing in the mid 80s.
It's early still, and there's a chance that Garcia's fastball ramps up as the weather warms, but that' no guarantee. Last year he averaged 88.5 mph on his fastball in April, but then just 87.5 mph the rest of the way. He did adjust then, though, leaning on his changeup far more often than his fastball, and mixing in the slider more prominently. I can see similar changes this year, especially if his velocity follows a similar trend.
Today on the podcast I asked Mike whether he believed that Garcia could continue getting hitters out with the general slop he threw on Saturday. He gave the answer that I've been wrestling with: heart says yes, head says no. How can anyone succeed throwing mostly off-speed junk? I'm not sure, but we not only saw Garcia do it on Saturday, but we saw him do it against one of the league's best offenses — one that tagged up his rotation mates Ivan Nova and CC Sabathia.
Chances are Garcia can't sustain this. But that's not my concern right now. All I want to do is heap a little praise on a guy who, without any semblance of a major league fastball, spun, tilted, and palmed his way through a tough lineup. It was an impressive debut, and an important one, too. With Hughes on the DL, CC getting off to a slow start, and Nova struggling, the Yanks needed that from Garcia.
Has Cano's plate discipline taken a step back?
It's not often that you can look at a player hitting .310/.322/.621 (.403 wOBA) and feel like his performance has stepped back from last year. Maybe it's just me and/or maybe Robinson Cano has spoiled us all, but there's one part of the second baseman's game that has taken a nose dive during the first 14 games of the season: his plate discipline. At least superficially anyway; Cano has drawn just one walk this season and his 3.14 pitches per plate appearance ranks 197th out of 200 qualified big leaguers. The only three below him are noted hackers Orlando Cabrera (3.10), Miguel Tejada (2.97), and Vlad Guerrero (2.97).
Cano set career highs in walks (57), unintentional walks (43), walk rate (8.2%), and unintentional walk rate (6.2%) last season, but he did so while swinging at 36.5% of the pitches he saw outside of the strike zone. That was also a career high, and ranked 184th out of the 205 players with 400 or more plate appearances. So given Robinson's utter lack of walks this year, you'd think that he's swinging at even more pitches out of the zone, right? Wrong.
The table above is taken right from Cano's player page on FanGraphs, and you can click for a larger (and easier to read) view. Cano is actually swinging at fewer pitches outside of the strike zone this year, albeit but a very small amount, but the real change comes on pitches in the zone. He's hacking at four out of every five pitches over the plate, and making contact at his usual (and absurdly high) rate. This suggests that he simply isn't getting into many deep counts, and the data backs it up.
Baseball-Reference shows that Cano has not worked a single 3-0 count this season, not once in his 59 plate appearances. Furthermore, he's only been in two 3-1 counts and two full counts. Two (each)! That's four three-ball counts all year, or 6.8% of his plate appearances. Last season Robinson worked a three-ball count 113 times (that's removing the 14 intentional walks), or in 16.6% of his 682 plate appearances. In 2005 and 2006, his first two years as a big leaguer, it was 9.2%. It hasn't dipped below 11.8% since, so clearly this is completely out of the norm for Cano.
So you know what that tells me? That this utter lack of working the count is just an unsustainably bad pace for Robinson. It's more of a small sample size issue than a definitive regression in his plate discipline. I haven't seen anything in his at-bats to suggest otherwise, he's still very productive and hasn't turned into an easy out. Cano has established himself as a .320 BABIP guy over the last few seasons, so he's got a tiny little bit of a rebound coming there (he's at .304 at the moment) plus what should be a huge correction in his walk rate. A .322 OBP is not good by any stretch of the imagination, at least not for a middle-of-the-order guy, but Cano is underperforming his career norms and looks poised to bounce back into the .350+ OBP range once we get a little deeper into the season.
The RAB Radio Show: April 18, 2011
The Yanks faced their biggest challenge of the season, facing the Rangers and their high-powered offense. They came out of it well, though, taking two of three. They are now the only AL East team over .500. Mike and I discuss the main points of the weekend, including Eric Chavez replacing A-Rod, the bullpen, and Phil Hughes's trip to the DL.
Podcast run time 29:55
Here's how you can listen to podcast:
- Download the RAB Radio Show by right clicking on that link and choosing Save As.
- Listen in your browser by left clicking the above link or using the embedded player below.
- Subscribe in iTunes. If you want to rate us that would be great. If you leave a nice review I'll buy you a beer at a meet-up.
Intro music: "Die Hard" courtesy of reader Alex Kresovich. Thanks to Tyler Wilkinson for the graphic.
This week's annotated box score
Last week I pointed you towards Sam Miller's annotated breakdown of the Yankees-Red Sox game, and since the Bombers played in last night's ESPN game, they are again featured in the annotated box score. This week Sam looks at the then-prospect status of both Robinson Cano and Mariano Rivera, which is a blast. Like I said last week, it gets RAB's highest level of recommendation, so check it out.
Fan Confidence Poll: April 18th, 2011
Record Last Week: 4-1 (27 RS, 21 RA)
Season Record: 9-5 (77 RS, 68 RA, 8-6 pythag. record), 2.5 games up
Opponents This Week: Monday OFF, @ Blue Jays (two games, Tues. & Weds.), Thursday OFF, @ Orioles (three games, Fri. to Sun.)
Top stories from last week:
- The week started with two days off; one scheduled and one due to rain. Homeruns and A.J. Burnett gave the Yankees a win on Wednesday, then Nick Swisher did the honors with a walk-off sacrifice fly on Thursday for a quick two-game sweep.
- The Rangers were the next team to come to town, but the Yankees hit into a franchise-record six double plays in a loss in the opener. Freddy Garcia was pretty damn good in Saturday's win, and Eric Chavez stepped in for Alex Rodriguez to provide the game-winning hit yesterday.
- Following his third straight ugly start on Thursday, the Yankees stuck Phil Hughes on the disabled list due to a "dead arm phase." Hughes didn't think a trip to the minors would help with his missing velocity/poor location despite some mechanical adjustments. He was placed on anti-inflammatory medication and started a throwing program over the weekend.
- Injury Zone: A-Rod left Saturday's game with a stiff back/oblique, and he sat out Sunday's game as well. An MRI came back clean. Pedro Feliciano was diagnosed with a torn shoulder capsule, effectively ending his season before it even began. Luis Ayala was placed on the disabled list with a strained lat. Dellin Betances (blister), Manny Banuelos (blister), and Gary Sanchez (oblique) all hit the DL on the minor league side.
- Hector Noesi took Ayala's spot on the roster while Lance Pendleton got Hughes' spot. Kevin Millwood was okay in a start for Double-A Trenton, though the reports on his stuff are still terrible.
Please take a second to answer the poll below and give us an idea of how confident you are in the team. You can view the Fan Confidence Graph anytime via the nav bar above, or by clicking here. Thanks in advance for voting.
Chavez steps in, buries Rangers in rubber game
The Texas Rangers have proven to be quite a pain in the ass over the last year, but that doesn't make them unbeatable. Sunday night's rubber game was a reminder that the Yankees are never quite out of any game because of their power, their bullpen, and their deep bench, all of which they used to secure the series win.
Back From The Dead
Over the last few years, the drop-off from Alex Rodriguez to his replacement has always been massive. It didn't matter if it was Cody Ransom or Ramiro Pena or Morgan Ensberg or whoever, it's always been a huge loss of production. The Yankees sought to deepen their bench this past offseason, and although it's still extremely early, it looks like they hit the nail on the head with Eric Chavez. The former Athletic stepped in for Alex on Sunday night and although he'll never fully replace him, the Yankees didn't miss a beat.
When Chavez stepped to the plate in the eighth inning against the Rangers on Sunday, a back-and-forth affair that featured homers and errors and thunder (literally) came down to essentially one at-bat. The Yankees had runners on first and second with two outs against noted Yankees' whipping boy Arthur Rhodes, someone Chavez had already faced 25 times in his career. He took two straight sliders for a 2-0 count, but then Rhodes went after him with fastballs. The first was fouled back, the second on the outside corner for strike two. Chavez, standing at his locker with his throwing shoulder wrapped in ice after the game, said he was looking for the slider all at-bat, but that 2-2 count brought a fastball, and A-Rod's fill-in adjusted to the pitch and took it right back up the box. Mark Teixeira did his puffy faced hustle around third to score the go-ahead run on Chavez's single, which may have earned him True Yankee™ status. At +.265 WPA, it was the biggest play of the game for New York.
As if the game-winning hit wasn't enough, Chavez also turned a sweet 5-4-3 double play in the third and assisted on the game-ending ground out. Zombie Eric Chavez, back from the dead and raising hell. Hooray for a deep bench.
Too Many Homers!
If you watched and listened to ESPN's broadcast of the game, then I'm sure you heard their announcing crew bemoaning the fact that the Yankees have hit a lot of homeruns. They acted like it was a bad thing; creating runs with one swing is ruining baseball, apparently. Well the long ball kept New York in this game before Chavez had a chance to do his thing whether ESPN liked it or not.
Robinson Cano got the got the party started right in the second inning, pulling an inside slider deep into the second deck in right for the Yankees' first run. Russell Martin followed up three innings later with a two-run shot, his fourth of the season. He had five all of last year and seven in 2008. Curtis Granderson went deep an inning later, putting two more runs on board. It was his first homer off a right-handed pitcher this season, believe it or not. Alexi Ogando allowed two dingers all of last year, but he paid dearly for being a pure two-pitch pitcher facing this lineup multiple times.
CC Sabathia wasn't great tonight, but really it was only Michael Young and Adrian Beltre that cost him. Those two combined to go 5-for-6 with two doubles and a homer off the Yankees' ace while the rest of the Texas lineup went 3-for-19 with two walks with six whiffs. The big guy took the ball into the seventh and although four runs in 6.1 IP won't win him any Cy Young Awards, it was enough to keep his team in the game. More often than not, they'll win those contests.
Joba Chamberlain, working for the second day in a row and the third time in four days, relieved CC and immediately walked Ian Kinsler on four pitches. Young drove him in two batters later, which is annoying because that guy really isn't as good as he looked this weekend. Joba escaped the inning without further damage, and Rafael Soriano did a nice job of redeeming himself for Saturday's debacle with a scoreless eighth inning in a tie game. Mariano Rivera, of course, was his usual self in the ninth, nailing down the 6-5 win.
Jorge Posada's assault on the three true outcomes continued with a pair of walks in four plate appearances, and now 22 of his 50 trips to the plate this year have ended with ball four, strike three, or a slow trot around the bases. Derek Jeter picked up a hit and even hit another ball with authority to the opposite field, his third hard hit ball in the air over the past two days. Progress! Chavez and Martin each had two hits, and Nick Swisher chipped in a single as well. It was a total team effort offensively tonight, the six runs were scored by six different players.
The Yankees sent 108 players to the plate in this series, and just nine struck out. Nine! Nine others walked and six homered. Everyone else had a .226 BABIP. If you're not missing bats against a lineup like this, well you're not going to win games. It's that simple. Texas, if you're wondering, sent 110 batters to the plate. Eighteen struck out, 12 walked, one homered, and everyone else had a .253 BABIP.
How about that thunder and lightning? It felt like my entire building shook, so yeah, that was pretty intense.
WPA Graph & Box Score
MLB.com has the box score and video highlights, FanGraphs some other neat stuff.
Up Next
The Yankees are off on Monday, then they'll head to Toronto for a quick two-game series against the Blue Jays. A.J. Burnett squares off against Kyle Drabek on Tuesday.