text:
|Home | About | Journals | Submit | Contact Us | Français
Several studies have implicated the 5-HTTLPR polymorphism in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. The aim of this study was to examine the association between polymorphism in the serotonin transporter gene and citalopram effectiveness in Iranian patients suffering from major depressive disorder (MDD).
The sample consisted of 104 patients, with Fars ethnic background, who were diagnosed according to DSM-IV-TR criteria. Beck Depression inventory was used to evaluate the severity of the symptoms during the follow-up, and to determine clinical response of the patients at 4th and 8th week, respectively.
Our results showed a correlation between the genotype and response to antidepressant drug citalopram, (odds ratios for L/S and L/L were 3.90 (95 percent CI: 1.29- 11.80) and 1.90 (95 percent CI: 0.72-5.08), respectively).
In conclusion, our results reveal that genetic variation of serotonin transporter is involved in clinical remission of major depressive episodes in Iranian patients after citalopram treatment.
Major depressive disorder (MDD) is a familial disorder, and is mostly resulted from genetic factors with a high prevalence (16.2%) (1, 2), although the effect of environmental influences is etiologically significant, antidepressant response is highly influenced by genetic constitution, but the actual genes involved have yet to be determined (3).
Depressive disorders have a large impact on social health (4). As it has been predicted that MDD would be the second leading cause of death and disability by the year 2020 (5), it became an ideal target for pharmacogenetic approaches (6). Based on many treatments which are commonly used for these patients, it can be stated that although a considerable proportion of patients benefit from the treatment, more than half will fail to respond adequately to the first antidepressants they are prescribed (7, 8). Among all choices of MDD treatment, the selective serotonin reuptake inhibitor (SSRI) antidepressants are mentioned as the first-line treatment of depression (9), but an estimated 30%-40% of patients with depression do not sufficiently respond to treatment with SSRIs (10) and the period in which treatment efficacy can be assessed is relatively long (11).
The molecular mechanism of ADs action, in particular, selective serotonin reuptake inhibitors (SSRIs), involves the inhibition o f the serotonin transporter, and thus modulates the serotonergic activity (12). The human gene-encoding serotonin transporter (SLC6A4), is located on chromosome 17q11.1-q12 (13), which is the first candidate of approaching a genetic predictor of response to SSRIs (14). There are several functional polymorphisms in the SLC6A4 gene (The serotonin transporter gene-linked polymorphic region) (5-HTTLPR) (15). The common length polymorphism is constituted by a deletion or insertion of 44 base pairs in the regulatory region of the promoter and gives rise to short "S" and long "L" forms of the promoter region (16, 17).
The long allele is known to be associated with more efficient transcription (18), higher SLC6A4 expression, producing a gain-of-function phenotype, resilience to depressogenic effects of adversity (19), and better response to SSRI antidepressants (20).
Many studies have focused on the functional insertion-deletion promoter variant serotonin transporter-linked polymorphic region (5HTTLPR)) in the serotonin transporter gene (SLC6A4) (21). Meta-analysis suggests that s/s individuals are at a higher risk for unipolar depression but just a modest trend for bipolar depression, while other studies indicate that the s/s genotype increases the risk of bipolar depression but not unipolar depression (22). Some other meta-analysis studies showed that long-allele carriers have higher probability of response and remission than short-allele homozygotes, and on the other hand significant heterogeneity of 5-HTTLPR effect has been reported in non-European populations (23).
Whereas no effect of 5-HTTLPR on efficacy of citalopram was found in a large mixed-ethnicity sample (24), an ethnicity-sensitive re-analysis of the same sample found an effect in the expected direction among White non-Hispanic participants (25).
On the other hand, gender may be another important factor influencing the relationship between 5-HTTLPR genotype and antidepressant response. Ovarian steroids have a significantly strong influence on serotonin synthesis (26), expression of serotonergic receptors (27), and the transporter of serotonin (28). It seems that further studies and evidences on the potential association between 5-HTTLPR and depression or response to antidepressant drugs are needed. Our aim was to explore the association between the 5-HTTLPR polymorphism and response to an antidepressant drug (citalopram) in Iranian depressed patients.
At first we included 190 major depressant patients. Sample size was computed using this formula.
The subjects were selected by nonprobability method from Akhavan and Saba Treatment and Rehabilitation Clinic, Tehran, Iran. Written informed consents were taken and the study was approved by the Ethics Committee of Ethnics in the University of Social Welfare and Rehabilitation Sciences. Diagnoses were established according to the Diagnostic and Statistical Manual (DSM)-IV-TR criteria and only nonpsychotic major depressive disorder was included. An expert psychiatrist interviewed all of the patients. Diagnosis of bipolar disorder led to exclusion from the study. Patients were between 18 and 65 years of age and had to be free from psychiatric drugs at least four weeks before their entry into this study. Exclusion criteria were as follows: Lactation or pregnancy, Drug abuse (If a patient had a history of drug abuse at least four months prior to the study, he/she was excluded from the study), suicidal ideation, co-morbid severe disorders. The study consisted of one hundred and four research subjects suffering from major depressive disorder (male: 26; female: 78; 18-65 years old). Of the subjects, 25 came back to drug usage, 20 abundant their treatment, and 41 could not follow the therapeutic process systematically, and were excluded from the study.The treatment regime at level 1 aimed to evaluate outcome of treatment with the antidepressant drug citalopram (minimal dose: 20 mg/d). To reduce the risk of inadequate dosing, and to ensure that patients who progressed to the next level of the treatment were truly resistant to the level 1 treatment, the study was carried out with a desired end point after 14 weeks of treatment which is regarded as a long enough period for adjusting an optimal dosage and evaluating the corresponding effects. If deemed necessary, patients were, however, allowed to proceed into level 2 before 4 weeks of the treatment (40-60mg/d), and were included in this analysis if they had received at least 8 weeks of treatment with citalopram. Concomitant psychotropic drug that patients used was alprazolam up to 2 mg/d for sleep (Until 15 days and then tapered). In the next visit (3-4 weeks later), depression symptoms and the recovery rates were studied.
After examining the mental state of each patient, the severity of depression was assessed with Beck Depression inventory. Patients whose scores were above 16 were identified as having major depressive disorder. Adherence was monitored by weekly self-reports which corrected by a psychiatrist, and plasma levels of antidepressants were measured at weeks 4 and 8. Adverse effects of medication were measured using the UKU Side-Effect Rating Scale (29) and Self-Report Antidepressant Side-Effect Checklist (30). The same rater was used in the first and following ratings of each patient. Clinical response was defined as improving in clinical finding and beck scale.
To determine HTTLPR genotypes, genomic DNA was extracted from whole blood by salting out method (31) and polymerase chain reaction (PCR) amplification to generate the 487- or 523- base pair fragments corresponding to the S and L 5-HTTLPR alleles, respectively. Amplification of genomic DNA was performed using 50 ng DNA, 0.25 mM of each primer (forward: 5'-GGC GTT GCC GCT CTG AAT C-3' and reverse: 5'-GAG GGA CTG AGC TGG ACA ACC AC-3') (32)
Reaction conditions were 1X PCR buffer; 1X Q-solution (Qiagen), 0.2 mM dNTPs, 2 mM MgCl2 (total concentration including from buffer); 20 ng/μl of each primer and a total of 10 ng of DNA in a 10-μl reaction. To obtain the best sharp bands, 10% DMSO was added per each reaction.
Cycling conditions were 95°C for 3 min; 35 cycles at 94°C for 1 min, 58°C for 1 min, 72°C for 45 s, 72°C for 5 min, and hold on 4°C. The labeled PCR products were separated on 2% agarose gel to differentiate the L (523bp) and S (487bp) variants. Plasma levels of citalopram were quantified using HPLC. The analysis was performed on a Knaver HPLC system (Smart model), consisting a UV detector and an injector with 100µl loop. Chromatographic separation was achieved isocratically at room temperature on a Spherisorb ODS2 column (250 mm×4mm, 5µm particle size (LKB, Bromma, Sweden). THE plasma level of all the patient's citalopram were in the therapeutic range (30-130 ng/ml).
Researchers who were blind to the clinical scores of depression performed quantification of plasma levels and genotyping. The clinician-rated 21 items of Beck Depression inventory was used to measure the treatment response at each treatment visit and at the end of the treatment period of up to 12 weeks.
In the categorized outcome definition, remitters were defined as having a Beck score ≥10 at endpoint of the level 1 treatment, whereas non-remitters still had a score ≤10 at the last visit as long as they were not classified as intolerant of the medication. In a parallel analysis, response was defined as a 50% reduction of Beck score at the last treatment visit and non-response as less than a 40% reduction. In order to minimize the risk for misclassification, individuals who received scores between these ranges or had less than 6 weeks of treatment were excluded from the respective analysis. After such exclusions, a total of 104 individuals were eligible for the treatment-response study when response was the outcome.
Clinicians were blind to the plasma levels and genotype of each patient till the end of the study.
At first, we used chi-square to test the significance of association between sex, genotype and treatment. Then, we used logistic regression to model the relationship between the odds of treatment and sex and genotype. Two independent variables were entered into a logistic model simultaneously to assess the predictive ability of each variable while controlling for all other variables. The interaction term between sex and genotype was dropped from the model because it was not statistically significant. The results are presented as the odds ratios and the 95% CI's. The Hosmer and Lemeshow test was used in this model to evaluate the significance of improved port with introduction of additional variables. SPSS software Package, version 15, was used to analyze the data.
Of the one hundred and four participants, 36 (34.6%) were homozygous for the L allele (L/L genotype), 34 (32.7%) were heterozygous (L/S genotype), and 34 patients (32.7%) were homozygous for the S allele (S/S genotype).
According to our study, carriers of the L allele, either homozygous of L/L or heterozygous of L/S, had a better and faster response to the treatment with citalopram. On the other hand, gender should also be considered when examining the genetic effects of 5-HTTLPR on psychological outcomes (33). Significant main effects in participants treated with citalopram qualified the interaction effects especially in men. We found a statistically significant association between sex and treatment; citalopram response odds ratio was 4.22 (95 percent CI: 1.29-13.76) for men compared with women (Table 3).
An association was observed between L/S and treatment. Using S/S as the reference group, treatment odds ratios for L/S and L/L were 3.90 (95 percent CI: 1.29- 11.80) and 1.90 (95 percent CI: 0.72-5.08), respectively (Table 3).
Among patients treated with citalopram, those homozygous for the short allele had significantly worse outcome than long-allele carriers, and this effect of the 5-HTTLPR genotype was more considerable among males treated with citalopram but was absent among females treated with citalopram (Table 1). Odds ratio for males' genotype ((L/L or L/S) / SS) is equal to 0.074 with 95% confidence interval (0.006, 0.911), whereas odds ratio for females' genotype ((L/L or L/S) / SS) was equal to 0.516, with 95% confidence interval (0.201, 1.327).
Obviously, there is a huge difference between female's and male's genotype in response to antidepressant treatment.
As it is shown in Table 2, overall response of individuals with the L/L genotype and L/S genotype (70%), confirming a dominant effect of the L allele compared with the response of homozygotes of the S allele (47.1%). The statistical analyses proved the strong correlation between the presence of the L allele and better response to antidepressant drug citalopram, (P =0.023, and Pearson Chi-Square test statistic = 5.139).
There has been much recent interest in the use of genetic variants for the prediction of response to medication treatments (34), which is so important for the psychopharmacologic treatment of psychiatric disorders (20).
In this study of Iranian sample population for the SLC6A4 promoter polymorphism, we observed that specifically male carriers of the 5-HTTLPR long allele showed a better response to citalopram treatment than male short-allele homozygotes (P = 0.047), whereas such affect is absent among women (P= 0.167). Our study indicated a significant interaction between the 5-HTTLPR, drug and gender.
The finding of this study is consistent with that of previous reports of gender specific genetic influences on serotonergic function (35) that might indicate a biological interaction between the serotonergic system and ovarian hormones. Through the oestrogen alpha receptor, oestrogens stimulate the production of the 5-HT receptor that is involved in the regulation of serotonin release and is down regulated in response to serotonin reuptake inhibitors (27). Oestrogens also increase the expression of the serotonin transporter.
It is possible that the impact of the less functional short 5-HTTLPR allele is moderated by the oestrogen-induced stimulatory effect on serotonin transporter expression in hormonally active women. Although this evidence shows biological plausibility to the observed 5-HTTLPR-gender interaction, this finding requires replication in an independent sample.
Therefore, overall, the study revealed a significant correlation between carrying the L allele and better response to citalopram treatment that confirms the previous Western reports (36–39), and one meta-analysis (23), whereas it is in contrasts with a Korean study (40) and some other meta-analysis (24, 41).
We believe that there would be several possible explanations for this discrepancy. First, most of the previous studies were gender independent, so the number of female individuals who showed poorer response to treatment with the antidepressant drug, citalopram, might modulate the results. Second, the 5-HTTLPR polymorphism may be in linkage disequilibrium with a functional variant that affects SSRI response, and the extent of this linkage disequilibrium would be different in each of that ethnic populations. Thus, the association between 5HTTLPR genetic variants and SSRI treatment response may be ethnicity-dependent (42). Thirdly, this discrepancy may have resulted from differences in severity of MDD or subtypes for MDD populations enrolled in various studies, and as compared with the European American population, the L allele frequency in Chinese (42, 43) or Korean (40) populations was much lower.
On the other hand, we believe that therapeutic antidepressant effect may involve the interaction of many different genes. Therefore, a single gene may play only a relative role, and not be strongly associated with antidepressant response. Thus, analysis of the interactions of multiple genes implicated in the pharmacokinetics of SSRIs is suggested to be mentioned in future pharmacogenetic study of antidepressants, although It is unlikely that the 5-HTTLPR polymorphism alone will be clinically useful in predicting response to antidepressants in people with depression (44).
In summary, in this study it was revealed that for Iranian population, male patients bearing the 5HTTLPR L/L or L/S genotype have a superior response to SSRI treatment than S allele-carriers, supporting Western reports.
We would like to thank patients and their families for participating in this study. We also thank Khadijeh Jalalvand and Sanaz Arjangi from Genetics Research Centre and the directors of Akhavan and Saba Treatment and Rehabilitation Clinic for their cooperation in this research.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
Discuss the article on the Forums.
Amount of Canadian Government Funding for Chronic Fatigue Syndrome
Discussion in 'Action Alerts and Advocacy' started by boomer, Nov 2, 2010.

subset: commoncrawl


text:
When Barack Obama became the first African American to be elected President, not everyone was happy about it. FreeZone correspondents Anthony and Aaron discuss the complicated reaction to race and politics that happened after Election Night.
Enjoy discovering new music on 91.3? Donate now – it's music made possible by you!
67 Bedford Square Pittsburgh, PA 15203
Studio: 412.381.9900 Office: 412.381.9131
Contact Us »Sign Up for E-News »Privacy Policy »
RAD Works Here
Where the Music Matters
The First Green Station in the Nation


text:
Users Online Now:
Who's On?
Visitors Today:
Pageviews Today:
Threads Today:
Posts Today:
Join Our:
GLP Poker Rooms
Donate To GLP
Adv. Search
Back to Forum
Back to Thread
Message Subject
X Marks the Spot
Poster Handle
Anonymous Coward
Post Content
It's storming here too...Spirit...
Good day to clear the air...
I knew I started a shitstorm in hoping to find people like you guys who CAN talk about the information without all the personal bias's needing to be worked out still...
I miss the days where I could post my thoughts here without having to worry about crazy stalkers and their head games...
Any of my comments on that other thread about tolerating people it is directed more towards those kind of people...
So...if any of you thought it was directed to you personally and you're NOT someone who is posting crazy rants or insults then of course it wasn't directed at you.
And I want the air cleared becaues it's been too long I've been tippy toeing around those jerks afraid to say something that might set someone off.
They can cry and make fun of others as much as they want...free speech and all but they can do that in other threads... the abusive stalker trolling won't be just ignored by me anymore...I'm done with it.
Lesson learned...now it'd be nice to move on.
Please verify you're human:
Reason for reporting:
13 Important Elements To Look For In Every Staged Shooting Event
Gestapo In The USA: FCC Intimidates Press and Kills Free Speech at 5G Rollout
Democratic National Convention in Philly Is Not What We're Told About in the Media
Federal Judge Rules Hidden Microphones in Public Do Not Violate Constitution
Deutsche Bank's net income plummets
Sanders Supporters Walk Out Of Democratic Convention
Black Protesters at DNC SHOUTS: "Don't Vote For Hillary, She's Killing Black People"
Hillary Clinton will nominate justices to the Supreme Court who are prepared to overturn Citizens United."
Day After Clinton Cash Film's Go Worldwide, CEO Forced To Step Down
Ancient 'toilet paper' proves that Silk Road travelers spread parasites as they traveled
Sheriff David Clarke Says the DNC 'Seems to Be About Embracing Criminality'
Why News Junkies Are So Glum About Politics, Economics, and Everything Else
Here's What Happened When Democrats Recited 'The Pledge Of Allegiance' At The DNC
Superhuman Tech? Most Fear Worst..
Wikileaks Proves Primary Was Rigged: DNC Undermined Democracy
WIKILEAKS JULIAN ASSANGE Says He Has NEW Emails That Should Indict Hillary…And Why He's A Trump Fan
Undercover Video: Hillary Clinton Delegate Explains Her Deceptive Propaganda to Ban Guns
Is State Dept. Is Protecting Hillary Rotten Clinton's Presidential Bid?
Robots, drones fill police ranks
Companies around globe packing earth orbit with satellites to meet communications demands
Rise of black nationalist groups
Report: Mr. Robot's one-time only VR experience will return next week
'Kill More Cops' Graffiti Mural Appears on Freeway
DNC erects four-mile eight-foot tall fence around Philly convention site
Should the Postal Service Handle Your Loans as Well as Your Mail? Elizabeth Warren Thinks So.
Disclaimer / Copyright Info
Privacy Policy
Terms Of Use
with questions or comments about this site.
"Godlike Productions" & "GLP" are registered trademarks of Zero Point Ltd. Godlike™
Website Design Copyright © 1999 - 2015 Godlikeproductions.com
Page generated in 0.004s (1 queries)


text: home > digestion center > digestion a-z list > chorionic villus sampling index Chorionic Villus Sampling Chorionic Villus SamplingRelated Health News « Back to Chorionic Villus Sampling Index Sorted Alphabetically A-Z Sort by popularity Blood Test Detects Down Syndrome During Pregnancy Blood Test May Reveal Child's Sex Soon After Conception Blood Test May Spot Genetic Disease in Fetuses New Earlier, Noninvasive Paternity Test Developed Prenatal Test Presents Dilemmas to Expectant Mothers Sorted by Popularity (as on MedicineNet) Sort alphabetically Prenatal Test Presents Dilemmas to Expectant Mothers Blood Test May Spot Genetic Disease in Fetuses New Earlier, Noninvasive Paternity Test Developed Blood Test Detects Down Syndrome During Pregnancy Blood Test May Reveal Child's Sex Soon After Conception Suggested Reading on Chorionic Villus Sampling by Our Doctors Related Diseases & Conditions 14 articles Pregnancy (Week By Week, Trimesters) There are many symptoms involved in the 1st, 2nd and 3rd trimesters of pregnancy. The first early pregnancy symptom is typically a missed period, but others Miscarriage Miscarriage is the medical Sickle Cell Disease (Sickle Cell Anemia) Sickle cell anemia (sickle cell disease), a blood disease which shortens life expectancy, is cause by an inherited abnormal hemoglobin. Symptoms may include Early Pregnancy Symptoms Pregnancy symptoms can vary from woman to woman, and not all women experience the same symptoms. When women do experience Cystic Fibrosis Cystic fibrosis is a disease of the mucus and sweat glands. Cystic fibrosis is an inherited disease. The outcome of the disease leaves the body malnourished, Hemophilia Hemophilia is one of a group of inherited bleeding disorders. Hemophilia A and B are inherited in an X-linked recessive genetic pattern and is more common Pregnancy Planning Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes taking prenatal vitamins, Genetic Disease Genetic disease is a disorder or condition caused by abnormalities in a person's genome. Types of genetic inheritance include single inheritance (for example, Fragile X Syndrome Fragile X syndrome is the most common inherited form of mental retardation. It's caused by a mutation on the X chromosome. People with Fragile X syndrome Down Syndrome Down syndrome is a genetic disorder that is caused by an additional set of chromosomes in a developing fetus. Distinctive facial features, growth retardation, Achondroplasia A common form of short stature, Birth Defects Birth defects have many causes and currently, are the leading cause of death for infants in the first year of life. Some of the causes of birth defects Urine Blockage in Newborns There are many syndromes and defects that may cause urine blockage in newborns. Defects in the urinary tract that may cause urine blockage include vesicoureteral Sexually Transmitted Diseases and Pregnancy (STDs) When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital Medications 0 articles Procedures & Tests 3 articles Pictures, Images & Quizzes 1 articles Doctor's & Expert's Views 2 articles Health News 5 articles Health Features 1 articles Pregnancy & Newborns Newsletter Let MedicineNet deliver FREE to your inbox the latest updates and information on pregnancy and newborns. BONUS! Get a Free Health & Wellness PDF Guide when you sign up! *Privacy Policy From WebMD Pregnancy and Parenting Resources Having a C-Section? What to Expect How to Take Care of Your New Arrival How Pregnancy Affects Your Teeth Featured Centers Feeling Short of Breath? What to Eat When You Have Cancer Top 3 Anaphylaxis Triggers Health Solutions From Our Sponsors Frequent Constipation? Greater Food Accessibility Exclusives What Does Psoriasis Look Like? How to Prevent Muscle Cramps Blood Clot? Know the Signs and Symptoms Allergy Triggers: Do You Know Yours?


text:
Kitchen and bathroom faucets serve their purpose, but what about faucets for the other sinks in the house? Home bars, the laundry room, and the extra sink in the kitchen require faucets too! Accessorize these sinks with the simple yet stunning bar faucets from GROHE.
GROHE bar faucets have all of the beauty of kitchen faucets but are slimmed down to pour a steady stream of water. Meet all of your secondary sink needs with GROHE. And remember, all faucets over $100 ship for free.
Pro Pricing:
Start Saving


text:
Uploader: Anon | Time: 0:41
URL: http://www.videosexarchive.com/index.php?video=232816
Orgasm facial cumshotsSurprise!!!!! cum shot to your eyes!!!!!! pt.2
Amateur brunettes cumshotsMonster Cum Shot To the Face
Babes blowjob cowgirlTwo slutty nurses get naked to fuck a fat male patient
Anal bikini blondesMouthwatering blonde nympho likes to sit on face and on cock
Blowjob bra coupleMature chick Jane Doe is happy to ride this hard schlong
Blondes blowjob coupleExquisite model in fashionable stockings gets cum on boobs
Anal close up cum in mouthBitchy teen nympho gives a double blowjob to two black dudes
Blowjob fingering lickingPeter North Brings Out His Cum Gusher To Soak A Chick
Blowjob compilation facialCompilation Of Big Cum Shots To Sexy Faces
Amateur big blowjobMy part-time girlfriend cums over to please me!
Oldvsyoung teen stockingsOld man cumming thanks to young slut
Cumshots masturbation public nudityMy tribut to Brooke Skye
Babes blowjob braAdmirable Sunny Jay plays with two cocks gets cum on tits
Lingerie stockings fishnetBitch in red stockings spreads thighs to get lciked and pounded
Blondes outdoor hardcoreCum-thirsty slut sucks a few cocks swallows loads of cum
Deepthroat blowjob cum swallowGal In handsome undergarments Does Not Waste Any cum When She Blows
Erotic couple hardcoreSweet teen welcomes cock of her boyfriend to visit her pussy
Anal french pornstarsTribute to Chloe Des Lysses French classic pornstar
Hardcore threesome mmfBitchy hottie spreads legs to get double penetrated
Threesome blowjob lickingTeen slut gives her mouth and cunt to two dudes
CelebritiesTribute to Alessia Fabiani
Reality brunettes asianBubble-asses Asian Sharon Lee enjoys rear bang gets cum on tits
Anal babes pornstarsHailey Paige Tribute
MenAnother Tribute to Luvermarianne by Bronzenicguy
Blowjob cumshot facialCompilation Of Loves Of Cum Shots To The Face
Redhead milf cougarsMilf in fishnet stockings is ready to experience deep anal
Pornstar latina naturalTribute to sativa rose! compilation
Blondes blowjob cum in mouthGIrl with fair hair gets double penetrated enjoys cum in mouth
Anal blowjob coupleGuy fucks cunt and anal of a slut and delivers cum in mouth
Anal asshole blondesCandy ass Katy takes off her thong to get DP experience
Brunettes babes hardcoreSweetie in pink panties craves for sex and for loads of cum
Amateur brunettes hardcoreThe neighbor cums over
MenAnother tribute to Sarah
Blondes hardcore group sexElegant model Sylvia Laurent gives sexual services to two guys
Blonde blowjob facialSophie Sucks Major Cock And Takes Cum Shots To The Face
Blondes pigtails hardcoreBlonde cutie Jenny learns to give services to two guys
Big tits blowjob cum swallowJizm to Order
Ebony hardcore interracialEbony Jasmin welcomes two cocks to double penetrate her
Sclip teenylovers comHe splashes his cum on young lucie
Brunettes hardcore ffmFuckable brunette sluts with fat tits bounce on cock swallow cum
Ebony ffm threesomeGhetto Love Cums Down To One Cock
MenTribute to Sarah
Anal big tits blondesBlonde slut worships big black cocks and serves to two black dudes
Babes blowjob cum in mouthTwo wild sluts are going to get hammered extremely hard
Babes blowjob close upSkinny long-haired bitch welcomes hard cock to drill her shitless
Blowjob brunette cum swallowThis milf gulps All The shoots a explosion She Can Have To The Last droplet
Blowjob bondage rough sexCrissy Cums Likes To Fuck Hard And Rough.
Amateur blowjob pov (point of view)Goth Chick Swallows Huge Cum Shot To The Mouth
Anal blowjob hairySexy Angel Takes A Cum Shot To The Face
Homemade cumpilation facialMy tribute to the women of pornhub
Brunettes long hair natural titsSexy guy has to fuck this mischievous female agent
Uniform hardcore coupleSex appeal chick with fake tits rides cock swallows cum
Brunettes babes realityBusty angel turns to be a crazy slut fucking with three dudes
Blondes hardcore threesomeCum-thirsty bitch gets anal screwed swallows jizz
Foursome hardcore thongTwo milfs Flory and Cory gets banged swallow cum
MenCum Tribute to Lucy Pinder
MenTribute to luckylucylinda


text:
This page is about the movie star Nikki Cox. It contains the lattest information about she, filmography and thumb gallery of pictures of Nikki. We also recommend to you to visit sites of our partners for more info about Nikki.
Nikki Cox ProfileName: Nikki Cox
Photos and pictures of Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox & Kristanna Loken
Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox
Nikki Cox Topless Pictures!
Lattest Films featuring Nikki Cox
|50 Hottest Vegas Moments (2005) (TV) [Nikki - Host]
|Macy's Thanksgiving Day Parade (2004) (TV) [Herself - Interviewee]
|Intimate Portrait: Vanessa Marcil (2003) (TV) [Herself]
|Las Vegas (2003) (TV Series) [Mary Connell]
|Run Ronnie Run (2002) (film) [Nikki Cox - Kayla]
|Don's Plum (2001) (film) [Karen]
|Nutty Professor II: The Klumps (2000) (film) [Ms. Stamos]
|Nikki (2000) (TV Series) [Nikki White]
|Norm Show, The (1999) (TV Series) [Nikki - Taylor Clayton (1999-2000)]
|Sub Down (1997) (film) [Holliday's Girlfriend]
|She Cried No (1996) (TV) [Kellie]
|Glimmer Man, The (1996) (film) [Millie]
|Unhappily Ever After (1995) (TV Series) [Nikki - Tiffany Malloy (1995-1999)]
|Someone Like Me (1994) (TV Series) [Samantha "Sam" Stepjak (1994)]
|Bloodlines: Murder in the Family (1993) (TV) [Student #2]
|Danger Island (1992) (TV) [Ariel]
|Terminator 2: Judgment Day (1991) (film) [Nikki Cox - Girl]
|Family for Joe, A (1990) (TV) [Carrie Lewis]
|Ryan White Story, The (1989) (TV) [Andrea White]
|Paula Abdul: Straight Up (1989) (video) [Dancer]
Nikki Cox Profile | Filmography of Nikki | Photos & Pictures of Nikki Cox
Nia Peeples | Nancy Travis | Nicola Bryant | Natalie Desselle | Nicole Eggert | Norma Shearer | Nicole Kidman | Nona M. Gaye | Natasha Henstridge | Natalie Raitano | Nikki Reed | Nia Vardalos | Nikki Cox | Nora-Jane Noone | Natasha Richardson | Nastassja Kinski | Naomi Watts | Natashia Williams | Natalie Portman | Nancy Morgan | Nia Long | Natascha McElhone | Nicky Hilton | Nicoletta Braschi | Nell Campbell | Nicole Ari Parker | Nicola Warren | Nancy Kwan | Natalie Schafer | Nancy Carroll | Neve Campbell | Natja Brunckhorst |


text:
This hotel was a surprise! You never know what you are going to get with a Holiday Inn.... but this one is nice. The rooms are bright and clean. However, their pillows are all messed up. They have the soft / firm markers, but both rooms I had all the pillows were hard as rocks and overstuffed. Ouch. :( Everything else seemed OK for the room. The AC worked great in our room. The water pressure in the shower is not so great for rinsing long hair, but it worked.
The breakfast in the restaurant ends at 9:30, I think that is a bit early, glad we got there in time. However it is overpriced, and the food mediocre, I was not impressed.
The fitness center is well kept. Small, 2 treadmills and a stepper I think. Also an all in one weight machine. They will also take you to a Gold's Gym if you are a priority club member.
The pool looks nice, but I haven't had a chance to try it out. There is a volleyball net set up in the yard also!
- Official Description (provided by the hotel):
- The Holiday Inn Hotel Roanoke is nestled in the Blue Ridge Mountains and is centrally located to downtown Roanoke, 2 miles off I-81 and 1 mile from the Roanoke Regional Airport with complimentary airport shuttle. The hotel has 153 oversized guest rooms. All rooms have complimentary wireless and hardwired internet access. All public areas offer complimentary wireless internet access. Our event space and outstanding service makes Holiday Inn Roanoke the optimal meeting place in Roanoke. Our Catering Director coordinates every detail of your event, making us the favorite for weddings, conferences, banquets, military and family reunions and corporate meetings. Maintain your exercise regimen in our fitness center, swim year round in our indoor heated pool or relax in our hot tub. Catch up on work in our complimentary business center at this Roanoke Hotel. We are the only hotel in Roanoke that offers a private outdoor recreational area featuring two volleyball courts, outdoor heated pool, horseshoe pit and picnic area. Unwind in our full service restaurant Passports, for a sumptuous Dinner, cocktail or start your day with a hearty breakfast. Relax, it's Holiday Inn! Area attractions nearby: Blue Ridge Parkway, Virginia Tech, Valley View Mall, Taubman Museum of Art, Martinsville Speedway, Roanoke and Salem Civic Centers. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, IHG, Hotwire, Expedia, Hotels.com, Priceline, Odigeo and Travelocity so you can book your Holiday Inn Roanoke Valley View reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Roanoke Valley View Hotel Roanoke
- Roanoke Holiday Inn


text:
Nails by Sammijo Hutsell-Hall, Advanced Image, Lemoore, Calif.
Wash-ful Thinking8 photos
2016 Nail Tech Event of the Smokies23 photos
The Greek term "arthro" means joint, or a connection point. The meaning of "itis" is "inflamed.
Learn More
What are reasonable terms for a non-compete contract?
How do I announce to my clients that I will be moving to a new salon?
The new products I'm using are adding time to each appointment. How do I adjust my schedule?
Why isn't my Gelish application curing properly?
What's the cause of the pinkish-red oval area on the pad of my client's toes?
Get a free preview issue and a Free Gift
Subscribe Today!


text:
Foo Fighters Category Stumps 'Jeopardy!' Contestants On July 13, the popular game show 'Jeopardy' featured an entire category devoted to the Grammy-winning band.
Dave Grohl Jammed with Taylor Swift at Paul McCartney's HouseWhat happened next is worthy of a Charlie Murphy True Hollywood Story.
Dave Grohl is Now for SaleTo the tune of $35,000.
Dave Grohl Pens Letter Defending Loud Band Practice"For musicians that lack the resources to rehearse in professional facilities, a garage or basement is the only place they have to develop their talent and passion."
Dave Grohl Prank Calls Survivor Host Jeff ProbstApparently the two have been friends for quite some time and the prank is on-going.
Lady Gaga & Dave Grohl Celebrated the Oscars By Chugging BeersGood old fashioned red Solo cup fun.
Watch a Drummer Cover Nirvana's Drum Chronology in 5 MinutesKye Smith spans Nirvana's discography, segueing through each album's tracklist with impressive timing and accuracy.
David Bowie Declined to Collaborate with the Foo Fighters"I got to be honest, it's not my thing."
Dave Grohl on the 'Nirvana Aesthetic'"The sense of humor was just so bizarre and abstracted and off that it was f------ hilarious. It was fun to be in that band."
Rihanna, Dave Grohl, Chris Stapleton and More added to Lionel Richie GRAMMY TributeThe artists join an already star studded lineup.
Dave Grohl Leads Supergroup Performance of 'Ace of Spades' at Dimebag TributeKROQ's Nicole Alvarez gives her account of Dimebash, where Dave Grohl, Philip Anselmo and more paid tribute Dimebag and Lemmy.
Ethiopian Students Celebrate Dave Grohl's Birthday with 'Smells Like Teen Spirit' VideoFrom the same folks who brough you "Even Flow".


text:
"Nascent" Cu(0) nanoparticles-mediated single electron transfer living radical polymerization of acrylonitrile at ambient temperature
Zn(0)/ppm concentrations of CuBr2 from 10 to 50 ppm was firstly used to catalyze radical polymerization of acrylonitrile at ambient temperature. The polymerization displayed typical living radical polymerization (LRP) characteristics, as evidenced by pseudo first-order kinetics of polymerization, linear increase of number-average molecular weight, and low polydispersity index (PDI) value. Effects of solvent, copper concentration, and initiator concentration on the polymerization reaction and molecular weight as well as PDI were investigated in detail. EC excelled NMP, DMF, and DMSO in terms of rate of polymerization as well as control of molecular weight and PDI. The increase of the copper concentration from 2.5 to 50 ppm leads to a higher rate of polymerization and a better control over the polymerization reaction. 1H NMR and GPC analyses as well as chain extension reaction confirmed the very high chain-end functionality of the resultant polymer. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.


text:
Read our comment standards
StarTribune.com welcomes and encourages readers to comment and engage in substantive, mutually respectful exchanges over news topics. Commenters must follow our Terms of Use.
- Keep it civil and stay on topic.
- No profanity, vulgarity, racial slurs or personal attacks.
- Comments with web links are not permitted.
- Comments that violate the above will be removed. Repeat violators may lose their commenting privileges on StarTribune.com.
Comments will be reviewed before being published.
More from Star Tribune
- Clinton introduces running mate Tim Kaine at Florida rally
- How sympathetic whites are helping to fuel racial change
- Obama rejects Trump depiction of U.S. as a nation in crisis
- Golden Corral will open in 2 former Old Country Buffets in Twin Cities
- Longfellow residents push to make 45th Avenue car-free for one block
- Donald Trump: The Dark Knight
More from Video
Afternoon forecast: More severe storms on tap
Afternoon Star Tribune Local Twin Cities (Minneapolis/St. Paul) Weather Video Forecast
Morning forecast: Severe weather threats, high of 92, humid
Morning Star Tribune Local Twin Cities (Minneapolis/St. Paul) Weather Video Forecast
Vikings organization reacts to the death of Dennis Green
Members of the Minnesota Vikings organization reflect on the passing of former head coach Dennis Green.
Gibson excellent against Red Sox on Friday
Gibson pitched eight strong innings to help the Twins shake off a bad outing
C.J.: Gripping chat with masseuse Sister Rosalind
C.J.: Gripping chat with masseuse Sister Rosalind


text:
Leaders in Cambridge
Opening hours
|Monday - Friday
Find us
About Leaders in Cambridge
Leaders is proud to operate in Cambridge, where we have two prominent branches in great locations. This allows us to offer tenants and buyers the widest range of property possible, while landlords and sellers benefit from the very best local market exposure and access to an experienced and knowledgeable team.
Cambridge offers a variety of buy-to-let investment opportunities, whether you are becoming a landlord for the first time or adding to your existing portfolio. There is a vast array of properties available, ranging from studio flats to large family homes – many of which offer attractive rental yields of around five per cent.
In addition, if you are looking to sell a property in Cambridge, we have potential buyers waiting to view it. Our award-winning team can offer advice on getting your home on the market, provide valuations and advise on how to achieve maximum interest in your property.
If you are selling or letting a property in Cambridge through Leaders, you will benefit from our expert marketing. We advertise on all of the top property portals such as Rightmove and Zoopla, as well as in local press publications, all of which ensures your property will gain maximum exposure to as many potential buyers and tenants as possible.
For tenants, Cambridge is a desirable place to live – the historic city has everything one could want. There is also a variety of properties available to rent which suit all requirements. The Leaders team in Cambridge can assist you in finding a home to suit your needs.
Rest assured that your tenancy agreement will be drafted by experts, and your deposits will be registered and protected. You will also receive the very best advice, as Leaders is registered with the Association of Residential Letting Agents (ARLA).
Come and visit us in branch or drop us a line for a chat about your property requirements.
You can visit us at our other branch in Cambridge which can be found at:
81 Regents's Street, Cambridge, CB2 1AW
Top properties in Cambridge
St Matthews Gardens2 2 1Fees apply £1395 pcmA two Bedroom first floor apartment ideally located close to the Grafton Centre. The property comprises of entrance hall, open plan living room with Juliet balcony and fitted kitchen featuring dishwasher, washer/dryer, electric oven and hob, extractor hood and fridge/freezer. There is a master be...
Shelly Gardens1 1 1Fees apply £1100 pcmA very spacious 1 bedroom flat centrally located just off Castle Hill, just a short walk from the city center. The property comprises of an open plan living/dining room and a fitted kitchen with appliances. Large double bedroom with walk in wardrobe and a good size bathroom with a shower over th...
Room Elizabeth Way1 1 1Fees apply £595 pcmA ground floor en-suite room available in a mid terraced property in a central location with accommodation comprising of entrance hall, a kitchen/dining room with oven, washing machine, fridge freezer and a door to the garden. On the first floor there is an additional shower room. Outside is a pa...


text:
Share < br />this article:
Celeb Snaps! Hottest Star Sightings – Tuesday 03.05.13
Barbara DeFranco
| March 5, 2013 - 1:38 pm
Share < br />this article:
View Full Size
Return to Story
Sean Combs
Recommended for you
Diddy Is Opening a Free Public School in Harlem Come Fall of 2016
Zac Efron Gets Misted and 27 More of the Funniest Celebrity Paparazzi Pics of the Week
Documentary Claims Diddy Was Behind Tupac's Murder
Jennifer Lopez and Diddy Still Sweet for Each Other At AMA After-Party
Celebuzz Cocktail Hour: DeLeón Platinum Tequila Drink Recipies
Viola Davis' Historical Emmys Speech Met With Twitter Rant from Soap Opera Star, Praised by Oprah
Around The Web
Here's Why Rob Kardashian Deleted All His Blac Chyna Photos on Instagram
Miley Cyrus Flaunts New Diamond Band on Her Wedding Ring Finger During…
Breaking Hair News: Ariana Grande Flipped the Switch on Her Hairstyle…
Rob Kardashian Unfollows Blac Chyna on Instagram, Deletes All Their…
Kourtney Kardashian's $50 Million Airbnb Is Nicer Than Your House
Sign Up For The Latest Celebuzz News
Thank you for signing up for our newsletter. You will receive a confirmation shortly.
Sign Up
Top Photos
All »
Taylor Swift and Tom Hiddleston Have a Date Night While Calvin Harris Spends Bro Time with Cristiano Ronaldo
The Kardashian-Jenner Family Leads Today's Star Sightings
Mila Kunis Shows Off Baby Bump at 'Bad Moms' Premiere
Blac Chyna Attends Kardashian Family Function with Ring, Without Rob
Kylie Jenner Wearing a Ring on THAT Finger Leads Today's Star Sightings
Breaking Hair News: Dakota Johnson Went Bold and Blonde
You'll Love
Zayn Malik Talks Dating Gigi Hadid
Mila Kunis' Wedding Ring Is From Etsy
Kim Kardashian Shades Taylor Swift


text:
Welcome to our Website
Studio & Location Photography Based in Ibstock near Coalville, Leicestershire.
Newborn Photography
Spring is here, time to book your location shoot? Dogs, kids and families too.
We are booking in playgroups and nurseries for spring/Summer term. Places are going fast so if you would like us to photograph your children then please ring soon as we do get totally booked up later on.
See our playgroup/nursery page for more detailed information.
We Now Do Cake Smashes For Your Child's First Birthday !


text:
Read: H-W Magazine
Free: Contests & Raffles
Join: Washington for Wildlife
Listen: Northwestern Outdoors Radio
There's never been a more important time: Join the NRA
YOUTH HUNTERS: WIN A FREE 2016 Guided Youth Turkey Hunt
Pages: [1] Go Down
Topic: Feel free to hunt (Read 5062 times)
Pages: [1] Go Up
FS: CABELAS OUTBACK LODGE TENT by cbond3318
[Today at 12:11:14 PM]
Starting to get a little bummed - no hunting this year by jkthomps
[Today at 12:09:08 PM]
Anyone else see the trail cam theives caught? by Woodchuck
[Today at 12:09:06 PM]
Boot Shrunk by Campfire Help by cbond3318
[Today at 12:08:24 PM]
What do you guys do with used cooking oil? by NRA4LIFE
[Today at 12:05:45 PM]
Camping around Wenatchee by gilroym
[Today at 12:04:34 PM]
Offer: Film Your Mt Clemans Sheep Hunt by Rainier10
[Today at 12:04:09 PM]
Protecting cell phone while hunting by NRA4LIFE
[Today at 12:03:33 PM]
Trekking poles by hoof rot
[Today at 12:02:17 PM]
GIVEAWAY - The Fallen Outdoors, 2ea Banquet tickets by Rainier10
[Today at 12:01:34 PM]
Annual Garden Thread 2016 by Twispriver
[Today at 11:57:05 AM]
Randle. Mt St Helens Trout Lake by Old Man Yager
[Today at 11:55:59 AM]
Best new inline in the $500 range (need it now) by PA BEN
[Today at 11:52:56 AM]
Opening day woes by Rainier10
[Today at 11:52:18 AM]
Ever do anything people say is stupid? by Old Man Yager
[Today at 11:51:06 AM]
Best Archery Pro Shop In Washington by predatorG
[Today at 11:49:00 AM]
Coyote Madness 9 by Scopebit
[Today at 11:48:00 AM]
Current production White's Boots vs Nick's...Drews? by Doublelunger
[Today at 11:40:49 AM]
Area 9 kings by Fishstiq
[Today at 11:29:49 AM]
Model 70 .300Mag by Sakko300wsm
[Today at 10:53:44 AM]


text:
I have an array that are already sorted.
Now I would like to take all the arrays that have a sub array value 0 and put them at the start of the array.
This is what I tried to do:
foreach($dealStatsArray as $deal_id => $dealStats)
if($dealStats['revenueY'] == 0)
$tmpArray[$deal_id] = $dealStats; // Store the array
unset($dealStatsArray[$deal_id]); // Unset the current one, since it is not in right position
array_unshift($dealStatsArray, $tmpArray); // Prepend the tmp array, to have it at the beginning of the array
Now problem is that array_unshift() does:
"All numerical array keys will be modified to start counting from zero" -php net array_unshift()
Which mess up the rest of the code I got because I need to keep the indexes on $dealStatsArray, and the index for the new prepended array should be the $deal_id and not 0.
How can I do this? And I need a solution that can manage to prepend 2 or 3 times to the beginning of the array, just like it works fine with array_push (appending) I would like to do that, but just prepending
Update: Here is my currently uasort function, that are sorting the array after the revenueY value, so that the highest number are in the start of the array and then descending..
function cmp($a, $b)
if (($a["revenueY"]) == ($b["revenueY"])) {
return 0;
return (($a["revenueY"]) > ($b["revenueY"])) ? -1 : 1;
uasort($dealStatsArray, "cmp");
Now if I follow @thaJeztah's answer, which partly works, then I added this under:
function sortbyRevenueY($a, $b) {
if ($a['revenueY'] == $b['revenueY']) {
return 0;
return ($a['revenueY'] == 0) ? -1 : 1;
uasort($dealStatsArray, 'sortbyRevenueY');
But this does not work correct, It does take all the revenueY==0 arrays and prepend at the beginning of the array, but then the rest of the arrays gets unsorted (highest to lowest, the first uasort())
Here's my final goal: To have an array where all the revenueY==0 are at the beginning of the array, and after these the top revenue are coming after and then descending to lowest revenue at the end of the array.


text:
Long Island Serial Killer Victims, Plus Atlantic City Women, All on Facebook After Death
Eight murdered women -- four found on Long Island among ten total bodies and four found in Atlantic City years ago -- have all shown up recently in fake Facebook profiles, the Philadelphia Daily News reports today. The creepy and sparse page for Kim Raffo, for example, found in 2006, features no photograph and is only "friends" with the three other women with whom she was found dead. All four worked as prostitutes, linking them to the four identified women dumped around Long Island's Gilgo Beach and Jones Beach, strangled and tied in burlap sacks, thought to be the work of a serial killer, though likely not connected to the Atlantic City killings. In a classic newspaper move, the News fails to link to or even picture any of the profiles, but we have them after the jump; the paper, though, does provide plenty of detail.
The victims include Molly Jean Dilts, 20; Kim Raffo, 35; Barbara Breidor, 42; Tracy Ann Roberts, 23; Amber Lynn Costello, 27; Megan Waterman, 22; Maureen Brainard-Barnes, 25; Melissa Barthelemy, 24.
The Dilts profile can be seen here, though there's not much to see, except that she is indeed friends with Raffo, Roberts, Breidor and Costello. Costello is only friends with Dilts and "Jane Doee."
Someone, or a group of someones, is taking creepy role-playing to the next level, though, by using their fake profiles to comment on a memorial page for another local murder victim, Anne Marie Fahey, who was killed by her lawyer lover in 1996. The Atlantic City profiles blame Fahey's murderer, Thomas Capano, for "their own" deaths:
"We are all angels," the Tracy Roberts profile posted on Jan. 29. The Molly Jean Dilts profile then made the suggestion that "we were all killed by the Capano's."
"We are still waiting for justice. We were found in November 2006 in Mays Landing, NJ," the posting read.
Immediately beneath Dilts' comment, a blank Facebook profile with the name "Colleen Marie" said the following:
"They should also be looking at them in connection with 4 . . . girls found in Babylon NY. If something happens to me it is because I knew what they did back then and I know what did to you girls. I think I'm next."
Upcoming Events
Staten Island Yankees vs. Auburn Doubledays
TicketsSun., Jul. 31, 4:00pm
2016 ICC Open Training
TicketsTue., Aug. 2, 5:00pm
New York Yankees vs. New York Mets
TicketsWed., Aug. 3, 7:05pm
International Champions Cup North America vs. Bayern Munich
TicketsWed., Aug. 3, 7:30pm
And so despite investigators pointing to differences between the two sets of found bodies, indicating that there are two killers, not everyone is convinced.
"The similarities are glaring. I still can't conceive you have two serial killers committing the same murders in so close an area," said one anonymous source. "It has to be the same person. He's just getting better."
That said, everyone is pretty sure the murderer is not behind the Facebook profiles -- there's certainly no shortage of fascinated borderline sickos with too much time on their hands.
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss Village Voice's biggest stories.
In Case You Missed It
Upcoming Events
Staten Island Yankees vs. Hudson Valley Renegades
TicketsFri., Jul. 29, 7:00pm
2016 Ny Jets Training Camp
TicketsSat., Jul. 30, 1:00pm
New York City FC vs. Colorado Rapids
TicketsSat., Jul. 30, 3:00pm
Usa National Womens Basketball
TicketsSun., Jul. 31, 1:30pm
Popular Stories
Sponsor Content


text:
May 27, 2011
Canon 50D
Nature, models, waterfalls and landscapes
I am photo enthusiasts that enjoys a wide variety of subjects. I am proficient with Photoshop and Digital imaging and specialize in nature, scenic and model portfolio images.
It is a great method of letting photographers know what is going on.
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
Microsoft unloaded a potential conflict of interest today when it agreed to sell Razorfish to Publicis for $530 million.
Microsoft had picked up Razorfish (then known as Avenue A | Razorfish) as part of its 2007 acquisition of aQuantive. That put Microsoft in a position where it was selling ads to itself, and buying ads from its search engine competitors.
Publicis helped Google out of a similar situation last year when it bought Performics from Google. Performics came to Google with the acquisition of DoubleClick.
Razorfish will continue to operate under its brand name and will be part of VivaKi, a Publicis entity that includes Digitas, Starcom MediaVest Group, Denuo, and ZenithOptimedia. Razorfish's management team, including CEO Bob Lord, will remain in place, according to a joint statement issued by Microsoft and Publicis.
The deal includes a 5-year deal where Publicis will get preferred rates on Microsoft's advertising properties, including its Bing search engine, as long as it meets certain ad-buying quotas.
Related reading
Google launches imported call conversions
If the internet killed the phone call, the smartphone has revived it.
Will Pokémon GO become a marketing platform for local businesses?
Nintendo's Pokémon Go, a free augmented reality (AR) mobile game, is on fire.
Five most interesting search marketing news stories of the week
Welcome to our weekly round-up of all the latest news and research from around the world of search marketing and beyond.
Eight key improvements from an ecommerce site relaunch
Ecommerce site Simply Hammocks relaunched a few months ago, and has so far achieved some impressive results.


text:
Pat and Ron: Shafted
I understand why a national
I understand why a national publication ranked them so low. If you're a Cubs fan, they're great. (I love Pat & Ron). If you're not a Cubs fan, Ron is almost unlistenable. Or so I've been told by non-Cubs fans.
(I posted this a couple
(I posted this a couple months ago...)
But it IS an outrage, and deserves further attention.
Oops, sorry Trans, looks
Oops, sorry Trans, looks like you posted it when I was in the middle of my move.
Well, I'm just now getting outraged about it, so there you go!
MIKEJ- Great post. Ron
Great post. Ron nationally is not liked and he is unbearable to listen to. I am a Cubs fan and almost get a rash if I have to be in a car while the game is going on. Pat is really good, great voice smooth transitions, always on top of the game, but Ron is just out of it and brings nothing to the broadcast unless the game is a blowout and then his "style" can then bring something to "entertain" the broadcast.
I'm a Cubs fan, and I find
I'm a Cubs fan, and I find Ron Santo almost unlistenable. He talks when he shouldn't, yells at the players instead of telling me the game, etc... No doubt he's a great part of Cubs legacy, but that doesn't mean I have to like his broadcasting.
The key with Santo is that
The key with Santo is that you have to view him as a mascot, not an analyst or even as a color commentator. When I made that change in my own mind, he got a lot more tolerable.
Occasionally, he actually offers some insight and it's almost like when your small child learns to spell his name. "Wow! Look what came out of Ron!"
Pat Hughes is a saint.
Those rankings are a bunch
Those rankings are a bunch of crap. They are nothing more than a publicity grab -- a weak attempt to generate controversy and sell papers. USA Today just wants fans to go to internet bulletin boards and post their reactions, and I for one won't let that happen!
>>>The key with Santo is
>>>The key with Santo is that you have to view him as a mascot, not an analyst or even as a color commentator. When I made that change in my own mind, he got a lot more tolerable.
Occasionally, he actually offers some insight and it's almost like when your small child learns to spell his name. "Wow! Look what came out of Ron!"
Pat Hughes is the Master of
Pat Hughes is the Master of Inflection.
I said it last time - I'm
I said it last time - I'm surprised they aren't lower. I can't even bring myself to listen anymore. Ron rambles like a senile old man, takes two innings to read a fax, then makes fun of Pat for being cheap and having an ugly sweater. Then he says "Oh boy" and we're supposed to call that analysis.
Pat sounds like Ted Baxter and often commits the greatest sin, missing pitches, to indulge Ron. They're banter is often painful to listen to, the interviews worse.
I find the Sox radio duo to be dull, but competent.
Pat Hughes and Steve Stone
Pat Hughes and Steve Stone would be the ultimate broadcast duo. I'll bet if Stoney hung with Hughes for a few monthe, Stoney's inflection would improve. Everything else is already perfect with those two.
Are you serious, you think
Are you serious, you think they should be higher? I think the rating is generous. While I feel bad for Santo for his health, he is the worst announcer EVER!!! Pat Hughes is a great announcer, unfortunately he is brought down by Santo.
DejesusFreak: "The key with
"The key with Santo is that you have to view him as a mascot, not an analyst or even as a color commentator. When I made that change in my own mind, he got a lot more tolerable."
Might as well make Ronnie Woo Woo the color commentator then.
Wow. I love Ron Santo as a
Wow. I love Ron Santo as a broadcaster and I know many non Cub fans who love his enthusiasm. The problem with these ratings are they are based on quick hits and the way Pat and Ron work together can work on many levels if you listen long enough.
I love Ron Santo for all he
I love Ron Santo for all he has overcome and the great years he gave as a Cub player, but he should be no where near a microphone.
If Chicago wants to live up to the image of a hick town with skyscrapers, keep Ron in the booth.
Pat Hughes is the most entertaining and descriptive play by play guys in the business. He is awesome, I was suprised he was not offered the TV play by play, but I've grown to like Ken Lasper.
Ramirez to the DL, Cedeno
Ramirez to the DL, Cedeno recalled.
I just have to say that I
I just have to say that I love Ron and Pat. Ron can be very fun to listen to...it is like sitting next to an older friend who really shares my enthusiasm for the game and love of the Cubs. In that light...all the flaws really don't amount to much. Ron cares...and that trumps most everything else.
I would much rather have Ron than some generic, corporate sounding Guy Smiley figure who is just gaming for a network gig.
And Pat...Saint Pat...not only is he one of the best in the business...he treats Ron with exactly the right sense of respect and friendship every true Cub fan would want.
DeJesusFreak, I admire your
DeJesusFreak, I admire your open-mindedness regarding Santo. Several years ago, a buddy explained to me, "Dave Otto's not stupid, he's just drunk. Look at that perma-grin." I went from hating Otto to being completely amused by him.
I'll never, however, find a redeeming quality in Chip Caray.
If you look on the USA today
If you look on the USA today site, they already posted the feedback that people have given to those rankings.
I looked for it today and couldn't find it. I read it yesterday, because the author of the rankings (Steve Gardner) called me earlier this week to verify that it was OK to use my comments about how Pat and Ron are better than they ranked them.
Manny - Nothing would make
Manny - Nothing would make Ronnie Woo Woo even close to tolerable excect disappearing from this earth. He's a scumbag, sideshow act and I have no trouble in stating that I'd wish he'd just go away so I never have to hear his ridiculous chant (or any other dope mimicking him).
I'm weighing in on this. I
I'm weighing in on this.
I don't friggin' care what national people think or rank broadcasts. I'm sure if they rated TV broadcasts Joe Morgan would be their top pick and he sucks bigtime as an announcer.
I want someone who bleeds Cub blue, who is a fan, who dies every time they screw up and blow a game. Insight is fine but with all the sports talk options I get enough critical insight. I don't want corporate density/sterility like we got with Joe Carter either. At least Ron's density is more related to him just getting a bit senile. We've had that before with Harry and Vince & Lou (stumbles and mumbles).
We have a person who personifies his emotions worn on his sleeve. I don't think a broadcast could have ever said more about a single play the Brant Brown call Ronnie did. The play by play stuff is done so beautifully by Pat Hughes. So in a city like Chicago, that's an earthy broadcast. I'm listening to them over our current TV side for most games.
Steve Stone in the TV booth? We had it all with Harry/Steve to complement Pat & Ron. Those days are gone courtesy of Dusty/Hendry/McFail's lack of backing Stoney up when Dusty's players went out of control last year.
I can't believe people
I can't believe people actually like Steve Stone. Since Harry passed, he has been acting like he knows EVERYTHING about the game. He also thinks that we are all idiots that watch the game. I don't need him to tell me "the next pitch should be a slider, and if it is--we'll be out of the inning...."
I don't need a color commentator anymore. We all know what is going on. The main purpose Santo serves is to have the connection with the fan. He feels like we feel.
Speaking of shafted, did
Speaking of shafted, did anyone notice this Tom Verducci gem in the August 8th SI? "Sandberg's entry opens the door for Roberto Alomar, Jeff Kent and Craig Biggio, all of whom have more prolific credentials than Sandberg and reflect
the offensive emphasis at the position in the past 20 years."
Firstly, how can credentials be "prolific"? Verducci is a hack.
Secondly, I won't argue the merits of one versus another, but Alomar, Biggio, Kent, and Sandberg rank on roughly equal footing in terms of the all-time greats. None is Eddie Collins or (gag) Joe Morgan, but all are terrific. Yet Verducci can't resist a shot at Sandberg. My theory is that he's bitter over the two division titles Ryno cost his beloved Mets in the '80s.
Question: Do you think Verducci and Little Joe were hanging out together on induction weekend, perhaps sticking pins into Ryno's baseball cards?
The nice back story and
The nice back story and history on Ron makes for an emotional connection like in 2003 where you could tell it meant as much to him as it did to the players on the field.
BUT, I live in Los Angeles so only listen to his broadcasts a few days a season...I too would have trouble listening to him daily. Pat hughes is great, but the chemistry is just off because their personalities are so different.
Ron is a nice story, and certainly the people who grew up watching him play feel a connection that some of us younger folk may not feel....he is a nice story...but his marketability overshadows his deficiant broadcast talents
i agree with Cubster. Ron
i agree with Cubster. Ron is our fan representative in the booth. He's one of us, not one of them.
I'm from the camp that if I
I'm from the camp that if I wanted to listen to a fan, why not just put a mike on a drunk fan in the stands...I like commentary...while on occassion I may know what is going on, it's still nice to hear from an analyst and get their perspective.
You can say that Stone thinks he knows everything...but we fans tend to think we know everything too...despite strong evidence to the contrary.
I haven't been impressed with some of Stone's egotistical antics of this year and a little bit last year...but as a color commentator, I think he was excellent
Adam, Ron is hardly a drunk
Adam, Ron is hardly a drunk fan with a mike. I am not old enough to have ever watched Ron play, but I look at him as a grandfather-type. Sure, he isn't the best at describing plays, but when something good happens, I know I can celebrate along with him. I love listening to Ron, even when he mispronounces peoples names, forgets parts of stories, etc. I also love how sometimes Pat corrects/helps him, and sometimes you can tell Pat just lets it go. I enjoy what Ron brings to the game.
Dave Otto reminded me of the
Dave Otto reminded me of the big puppet band on stage at Chuck-E-Cheese's when I was a kid. Every time he would say something he thought was important, he'd close his eyes and turn his head back and forth, then continue on with what he was saying, just like those mechanical animals.
"Adam, Ron is hardly a drunk
"Adam, Ron is hardly a drunk fan with a mike. I am not old enough to have ever watched Ron play, but I look at him as a grandfather-type"
I was going off the statement that others wanted a "fan like us" and "one of us"...it was more of a rebutal against the general statement...I agree, Ron is not close to the same level as drunk fan with a mike.
>Pat . . . often commits the
>Pat . . . often commits the greatest sin, missing pitches, to indulge Ron.
Listening to WGN radio, I often suspected this was the case (you'd hear the bat make contact with the ball while Ron was meandering through one of his stories where he could never quite gets the facts straight or remember the names of all the principals--and many seconds later, Pat would interject something like, "A grounder foul").
Then, I started watching the games on TV while turning the TV sound down, and listening to the play-by-play on radio. Turns out, they often miss several pitches an inning while Pat's busy indulging Ron.
Unfortunately, what Ron doesn't seem to have a grasp of is the cadence, the tempo, the feel for broadcasting a game on radio. Unlike TV, where you can get a bit long-winded (because the audience SEES the action on the screen), you've got to deliver your commentary in short bursts on radio to allow the play-by-play guy to call just about every pitch. You need to be able to EDIT your thoughts and work around the normal pacing of the game. Ron doesn't do that.
Cubster- I believe who you
I believe who you are describing would be "Hawk" Harrelson.
Show a little emotion but the moans and grunts are not the reason I'm listening to the game, I will decide for myself if that a play sucked. At least let me here it descibed by Pat.
Did you hear Hawk yell "Damn!" yesterday, when Twins tied the game? What a tool.
A good analogy for Ron's
A good analogy for Ron's broadcasting is that he is like a laugh track for a sitcom. I will laugh is the joke is funny, I don't need to be cued.
I think Santo is great. I
I think Santo is great. I just don't see why people don't like him. The vast majority of color commentators don't add much insight to the game. We need Ron around for entertainment, a guy who shows some emotion and cracks a joke at Pat's expense. I love the Cubs radio announcers.
Here's what I sent to the
Here's what I sent to the feedback:
How can you rank Pat & Ron 26th? That's insulting!
To the 4 teams ranked lower.
I love listening to a critical moment only to have Ron read a fax, forget the number of outs, forget the score, and be unable to see the play.
Then, Pat recovers by making some pithy joke.
I'm sorry, but Ron is seldom
I'm sorry, but Ron is seldom coherent. I'll listen to Pat all day, but Ron really, really grates.
I'm mystified at Uecker being ranked only 3rd. He and Jim Powell never miss a pitch and are endlessly entertaining. You have to be to make people listen to a Brewers game.
As a fan of a team that is
As a fan of a team that is not the Cubs, and additionally as a person who lived in the suburbs of Chicago for 9 years -
Pat Hughes is pretty good. Well above average in fact, and I liked listening to him.
Ron Santo is, I'm sure, a nice guy, who I think deserves to be in the hall of fame as a player. As an announcer, he's hands down the worst I've ever heard in my entire life. Maybe you can take it as a Cubs fan, but hearing him yell "NO" during a bad play and "YES" during a good play drove me nuts - I wanted to know what happened beyond knowing which way it went for the Cubs.
Although, his Brant Brown dropped ball yelling was entertaining.....
Maybe this topic has been
Maybe this topic has been worked to death, but with the games unremarkable (or unwatchable) at this point I find myself thinking about little things like: anybody else have a problem with Hughes not saying the score enough, or sometimes saying it obliquely?
I notice that he often starts innings (or half-innings) by pointedly talking about something *other* than the score, the game, baseball, etc. Also, an example of obliqueness: I usually can only tune in here and there to day games while I'm at work. Yesterday I did so just after Hairston hit his 3-run double, and Hughes said: "...and now it's a 7-4 game!" As somebody who hadn't heard anything about the game until that point, it left me more confused than informed.
Wow, Maybe now I know why
Maybe now I know why Santo comes to Baker's defense when Santo realizes the current manager doesn't live up to his billing. He hears this stuff and he has something in common with Baker and maybe he thinks Baker is getting a raw deal too (which I don't think he is getting a raw deal...Baker does suck).
I look at Ron as being a Cub that brings together all generations....current and past. He isn't there to do what Steve Stone was there to do. He isn't there to explain baseball...he isn't there to explain strategy...he's there to reflect on his feelings and experiences of being a Cub..it's not a typical color-commentary job.
As for Steve Stone....the man does know it all. He has great foresight in calling a game...For those who say he doesn't know it all...he does.
I love Ron Santo, and if I
I love Ron Santo, and if I ever got to meet the guy, I'd give that old cub a big hug and thank him profusely for years of entertainment, but his broadcasting leaves much to be desired. He simply is not a functional analyst. It's not even fair to call him an analyst. He's ron santo. He is the ultimate homer.
I want to learn something about the game from the analysts.
Ron will make a few insightful points each game, but for the most part, he's one of the least insightful analysts I've ever heard.
Pat Hughes is a play by play stud in my opinion.I can't imagine anyone dealing with ron better. He's witty, sharp, enthusiastic, professional, and has a tremendous voice. If I ever meet him I want to ask him to record my outgoing voicemail message.
Recent comments
Some perspective (mostly for my own benefit): Dan Straily beat MadBum 2-1 today as the Reds took 2 of 3 in SF. Giants are 2-9 since the break and their lead over LA is down to 2.5 games. So, yeah...baseball. It'll drive ya nuts.
McNutt / Archer didn't work out well for us.
The floor is more valuable than the ceiling. It's the same reason we drafted Kris Bryant instead of Jon Gray.
Apparently the Yankees had the choice of either Gleyber Torres or Eloy Jimenez in the Chapman deal, and they chose Torres.
Chapman shouldn't be reserved anymore on 40 man.
Interesting split on Heyward according to ESPN. As a CF, his slash line .292/.363/.375/.738. At RF: .212/.204/.300/.604. 21/72 as a CF, 58/273 as a RF.
He's also been better when batting 2nd, but he had a nice start in the 6 hole, but has slumped ever since. He was heating up before the All Star break, but is only hitting .108 in the 2nd half.
When we played the Reds with Chapman, I always thought of it as an eight-inning game. So now other teams have eight innings to try to get a lead against the Cubs. Should be a challenge, assuming three or four Cubs ever start hitting again.
I don't really try to get to know and like these players personally. I'm rooting for laundry, for the most part. Exceptions might be when a player makes trouble in the clubhouse or in the dugout. (Zambrano and Bradley come to mind. Also Papelbon.) But I don't think Chapman is one of those jerks.
Unfortunately, a pretty good summary. It looks like next year Heyward will be getting yet another batting stance adjustment.
The recent good news has been Baez. I'm afraid about the next league adjustment on him, though, which is probably right around the corner.
Bryant I don't worry about too much. Just not seeing the ball well right now. He'll turn it around. Russell's been good with men in scoring position all year and he's 22ish. He'll be fine but next year is likely to be his breakout year.
If Travis' back-to-back-to-back walks cost Hendricks the ERA title, that would really suck.
Edit: "A lifeless loss to a lousy Sox team."
This place is a real downer after a loss to the Sox.
I expect they will go 5-9 games above .500 the rest of the year. 96-98 wins will win the Division.
They should have one more 2-3 week hot streak in them.
However, several players are just "average" for the last month: Zobrist, Ross, Russell, Ceasar. Montero is terrible, plus he cannot throw anyone out. -WAR. Heyward is abysmal at the plate, but a plus in the OF. Still with RISP he has been terrible. KB has not been driving in runs as of late. But Apparently the team is still above average with RISP according to S Sahadev.
I came to that realization tonight. I kept expecting them to play better, but now I realize they aren't going to. They are a .500 team now.
- They have one reliable starting pitcher. Jake's magic is gone, and it doesn't look like it's coming back. Lester has been lousy recently. Lackey's ERA goes up every time he pitches.
- Heyward has been dead weight all year. I can't remember a single series where he was a significant offensive contributor. Not one. Great defense, but but if he were hitting .270 with 10 HR and played average defense, the Cubs would be better off.
new rule...no one's allowed to throw k.bryant a changeup
Team is .500 since early May and is playing like a .500 team. Lack of offense seems to be putting a lot of pressure on the pitchers...and they aren't handling it terribly well.
.500 the rest of the way still may win the division though.
...i hate espn.
nothing like settling into a cubs game to get a few minutes cutaway for an ortiz AB in the 6th inning of the det/bos game.
oh, at least they're doing split screen now...i guess.


text:
iRobot Roomba 770 Vacuum Cleaning Robot pictures and hands-onPocket-lint
The iRobot Roomba 770 vacuum cleaning robot promises to clean your carpets without you having to lift a finger, but is it really that easy?
Well, Pocket-lint has spent some quality time with the automated machine and can confirm that it sure is.
Set it up in your office, lounge or house, press the button and that's all there is to it really. The large ice hockey puck-looking cleaner then gets going, cleaning your carpets, hardwood, tile and linoleum floors, whilst randomly working its way around the room as if it was a lost tourist.
According to iRobot, that chaotic approach is all part of one big master plan. At first glance, you might think that the robot has missed an all important bit of dirt, but it will soon come back around to scoop it up.
Of course, this isn't the first iRobot automated vaccum cleaner, but it has several improvements over previous iterations.
New features this time around include a dust bin indicator light to let you know it needs emptying, enhancements to the sensors (the 770 now uses optical and acoustic sensors to detect large and small particles to sweep up), and a better cleaning head that gets to the edge of your carpet, brushing dirt into the way of the motor. There's also a new flip-out carry handle that lets you pick up the Roomba 770 a lot easier than its predecessors.
Combine those with the ability to set a timer so it can clean while you are out, and a sensor in the box so you can stop it going into certain rooms or down flights of stairs, and it's a simple yet complete package.
The iRobot Roomba 770 vacuum cleaning robot costs around £420 and is available now.
Would you trust a robot vacuum cleaner to clean your floors? And, do you have any ideas for other robot appliances that could help with the household chores? Let us know in the comments below...
Edit photos like the pros with the Ultimate Adobe Photo Editing Bundle (94 per cent off)
Anonymous and unrestricted browsing for life: TigerVPN full lifetime subscription...
Here is Facebook's internet-beaming plane completing its first test flight
Watch NASA's year-long timelapse of Earth from a million miles away
- Edit photos like the pros with the Ultimate Adobe Photo Editing Bundle (94 per cent off)
- Anonymous and unrestricted browsing for life: TigerVPN full lifetime subscription (93 per cent off)
- Here is Facebook's internet-beaming plane completing its first test flight
- Watch NASA's year-long timelapse of Earth from a million miles away
- Get 6 IT certifications with the Essential CompTIA and Microsoft Windows Server Administrator Certification Bundle (96 per cent off)
- Join the tech revolution: a 10-year '.tech' domain subscription is now 80 per cent off
- Earn a six-figure IT security career with the Become an Ethical Hacker bonus bundle (92 per cent off)
- Here's how much tech Amazon sold on Prime Day - its 'biggest day ever'
- Best Amazon Prime Day deals 2016 UK: Kindles, Xbox One, Chromebooks, Microsoft Surface, and more
- Streamline your work and protect your PC with the ultimate PC bundle (91 per cent off)
- Pokemon Go Gym tips: How to battle, train and win
- Help! Pokemon Go isn't working: How to fix common Pokemon Go problems
- Pokemon Go: How to play and other tips and tricks
- Pokemon Go: How to get the most from PokeStops and items
- Next Nexus (2016): Release date, rumours and everything you need to know
- Pokemon Go server problems: Why does the game keep stopping?
- Pokemon Go: How to find and catch rare Pokemon like Charizard, Blastoise and Alakazam
- No surprise here: Pokemon Go breaks App Store record, Apple says
- Best TV catch-up on Freeview Play: Robot Wars, Kinky Britain and more
- Samsung fixes Galaxy S7 Active's waterproof flaw, will replace phones


text:
There were a number of notable developments and news items in the world of e-books during 2015, and here is a recap that highlights some of the more significant stories of the year.
Starting the Year with a Celebration
The year began with a digital publishing awards ceremony hosted at the glitzy Hilton Midtown Hotel in NYC, and winners included the books Chinese Whispers and The Truth is a Cave in the Black Mountains in the adult fiction category. Top honors in nonfiction went to titles including two fashion-related books, Women in Clothes and Penny Chic: How to


text:
The Staybridge Suites Oak Ridge is an all suite extended stay hotel, located Off of Highway 62 in Oak Ridge.
This Comfort Inn is located within walking distance of the Oak Ridge Mall and approximately 25 miles from McGhee Tyson Airport.
The DoubleTree by Hilton Oak Ridge, Tennessee, 11 miles west of Knoxville, is Oak Ridge's premiere, full service hotel.
The Hampton Inn® Oak Ridge is located in the heart of the business district, within walking distance of the American Museum of Science and Energy and
Located in the historic birthplace of WWII's Manhattan Project, the Quality Inn in Oak Ridge, TN offers easy access to historical tours related to the
Fabulous location for Pigeon Forge vacation. Hotel Pigeon Forge Inn & Suites is located on the main parkway in Pigeon Forge. We're next door to Country Tonite Theater across the street from Titanic Musuem and 1 mile to Dollywood and Dixie Stampede
This mountain hideaway covers about 70 acres next to the Great Smoky Mountain National Forest, in the quiet community of Gatlinburg, Tennessee.
If youre looking for a Smoky Mountain getaway, Bluegreen Vacations Mountain Loft Resort TM, Ascend Resort® Collection in Gatlinburg, TN is your place
This Quality Inn is located less than a mile from Dollywood and approximately 45 miles from McGhee Tyson International Airport.
The Park Vista - a DoubleTree by Hilton Gatlinburg is located approximately five miles from Pigeon Forge and 45 miles from Tyson/Mcgee Airport.
Browse thousands of listings for Oak Ridge Tennessee.


text:
Located 44 km from Førde, Holiday home Lavik Lavik offers accommodation in Lavik. It provides free private parking.
The kitchen comes with a dishwasher, a refrigerator and a stovetop and there is a private bathroom. A TV with satellite channels is offered. Other facilities at Holiday home Lavik Lavik include a sauna....


text:
Residency Showcase
Residency Showcase - Friday, Nov. 6, 2015
1:30 p.m. - 4:30 p.m.
Free for Students and Exhibitors/Recruiters
UH Campus, South Ballroom at Student Center South (formerly the University Center), 4455 University Dr., Houston, TX 77204
Parking: UH Welcome Center Garage or UH Hilton Garage (parking fees may apply)
The Annual UHCOP Residency Showcase offers an opportunity for students from every pharmacy college/school in Texas to meet and learn about post-graduate residency positions in Texas, surrounding states and elsewhere across the U.S. from residency program directors, current residents and preceptors.
One of the largest residency events in the state, the Showcase draws more than 200 students and more than 30 institutions representing 40-plus different residency programs each year.
The event is free for students and vendors; however, exhibition space is limited. Parking is available in the UH Welcome Center Garage.
This annual event is hosted by the UH Student Society of Health-System Pharmacists, and sponsored by UHCOP.Questions? Please contact Dr. Paige Pitman at 713-743-1239.


text:
will be very aggressively
marketed nationwide,
even globally, to developers
and investors.
(Save the date: RealShare New Jersey comes to the Hyatt Regency, New Brunswick, NJ, September 19.)
EATONTOWN, NJ–Cushman & Wakefield/Continental Realty has been named the primary broker for development of the former Fort Monmouth property – 1,100 acres that sprawl across three towns near the Jersey shore and are now being transferred to state ownership.
Cushman & Wakefield was hired to market, sell and lease the property for the Fort Monmouth Economic Revitalization Authority. The FMERA was established through the state Economic Development Authority to devise and execute a reuse plan for the 94-year-old base, closed last fall.
Gualberto "Gil" Medina, executive managing director for CW tells GlobeSt.com that his company's affiliate, Ohio-based Continental Realty, was included on the brokerage team because it has handled comparably sized mixed-use redevelopment projects in Pittsburgh and Columbus, OH.
James V. Gorman, the board chairman for the FMERA, called the selection of a broker "an essential step" in the push to regenerate jobs and economic activity in Monmouth County around Eatontown, Tinton Falls, and Oceanport.
The agency is already in negotiations with AcuteCare, a company that would create 200 new jobs and invest an estimated $15 million to renovate a facility on a 16-acre parcel of the base in Oceanport. Also, it has approved a purchase-sale agreement with CommVault, a data management company that plans to build a 650,000-square-foot, state-of- headquarters on a parcel in Tinton Falls.
With the brokerage firm in place, "we are now in a better position to advance FMERA's mission and create an atmosphere in which employers will employ and investors will invest, to maximize the jobs created and the value of the property," Gorman said. For decades, Fort Monmouth served as the center for development of communications, computers, intelligence and reconnaissance for the U.S. Army; radar, FM radio, night vision goggles, and satellite communication were developed at the site.
"This property boasts remarkable assets that we want companies across the United States and throughout the world to know about," said Bruce Steadman of FMERA.
Cushman & Wakefield is to work in line with "the shared goals and interests of FMERA and the US Army" in redevelopment of the property, according to the wording of its contract. Last month, the authority signed an agreement with the Army that divided the land into specific parcels, which will be transferred to state ownership in two phases.
"It is our understanding," says Medina, "that many unsolicited expressions of interest have already come in about development at Fort Monmouth. Our next step will be to meet with leadership of the municipalities to get a sense and feel for what is important to them, and then create a systematic way to process the proposals that are most viable."
Medina says the property will be "very aggressively" marketed nationwide, even globally, to developers and investors. At this point, the variety of possible uses includes residential and retail along with office, warehouse and distribution, and possibly high technology facilities.
At the same time as the hiring of CW was announced, Jones Lang LaSalle was named an alternative broker to be used in case of a conflict of interest, as is standard procedure in large public/private projects.


text:
Performance Appraisal Fundamentals: A Quick Guide to Fair, Consistent, and Useful Performance AppraisalsPerformance Appraisal Fundamentals: A Quick Guide to Fair, Consistent, and Useful Performance Appraisals discusses common challenges local government managers and human resource (HR) practitioners face when determining whether the traditional performance appraisal/evaluation process is right for their organizations. This e-book equips local government managers with the knowledge and insight to
Capital in the Twenty-First CenturyThe main driver of inequality--returns on capital that exceed the rate of economic growth--is again threatening to generate extreme discontent and undermine democratic values. Thomas Piketty's findings in this ambitious, original, rigorous work will transform debate and set the agenda for the next generation of thought about wealth and inequality.
The Bottom Billion : Why the Poorest Countries are Failing and What Can Be Done About It
Why the Poorest Countries are Failing and What Can Be Done About ItGlobal poverty Paul Collier points out is actually falling quite rapidly for about eighty percent of the world. The real crisis lies in a group of about 50 failing states the bottom billion whose problems defy traditional approaches to alleviating poverty. In The Bottom Billion Collier contends that these fifty failed states pose the central challenge of the developing world in the twenty-first
Learning by Linking: Establishing Sustainable Business Learning NetworksThe Sustainable Learning Networks in Ireland and Wales project was part-funded by the European Regional Development Fund (ERDF) through the INTERREG IVA Ireland Wales programme 2007-2013. The project was undertaken by the Centre for Enterprise Development and Regional Economy, School of Business, Waterford Institute of Technology, Ireland in partnership with the School of Management and Business,
The Rise and Fall of American Growth
The U.S. Standard of Living since the Civil War
The Princeton Economic History of the Western WorldA NEW YORK TIMES BESTSELLERIn the century after the Civil War, an economic revolution improved the American standard of living in ways previously unimaginable. Electric lighting, indoor plumbing, home appliances, motor vehicles, air travel, air conditioning, and television transformed households and workplaces. With medical advances, life expectancy between 1870 and 1970 grew from forty-five to
The Unsustainable Future Of Our Economy, Energy, And EnvironmentThe next twenty years will be completely unlike the last twenty years. The world is in economic crisis, and there are no easy fixes to our predicament. Unsustainable trends in the economy, energy, and the environment have finally caught up with us and are converging on a very narrow window of time—the "Twenty-Teens." The Crash Course presents our predicament and illuminates the path ahead, so you
Think and Grow Rich! The classic personal development and self-help book by Napoleon HillThis carefully crafted ebook: "Think and Grow Rich! The classic personal development and self-help book by Napoleon Hill" is formatted for your eReader with a functional and detailed table of contents. First published in 1937, Think and Grow Rich by Napoleon Hill, remains an instant classic. It is widely cited as being the most of popular and influential self-help books of all time. In the book,
The Future of Economic Growth in a Multispeed WorldA Washington Post Notable Nonfiction Book for 2011 With the British Industrial Revolution, part of the world's population started to experience extraordinary economic growth—leading to enormous gaps in wealth and living standards between the industrialized West and the rest of the world. This pattern of divergence reversed after World War II, and now we are midway through a century of high and
Globalization and Its DiscontentsThis powerful, unsettling book gives us a rare glimpse behind the closed doors of global financial institutions by the winner of the 2001 Nobel Prize in Economics.When it was first published, this national bestseller quickly became a touchstone in the globalization debate. Renowned economist and Nobel Prize winner Joseph E. Stiglitz had a ringside seat for most of the major economic events of the
Health, Wealth, and the Origins of InequalityThe world is a better place than it used to be. People are wealthier and healthier, and live longer lives. Yet the escapes from destitution by so many have left gaping inequalities between people and between nations. In The Great Escape, Angus Deaton--one of the foremost experts on economic development and on poverty--tells the remarkable story of how, starting 250 years ago, some parts of the
Getting Started: A Peformance Measurement HandbookGetting Started: A Performance Measurement Handbook serves as an introduction to the topic of performance measurement for local governments that have not yet started measuring their performance, or that have taken the first steps but found that reaping meaningful results can be a challenge. This e-book focuses on the areas of planning, development, implementation, and refinement with access to key
$11.99From the poisoned rivers, barren wells, and clear-cut forests, to the hundreds of thousands of farmers who have committed suicide to escape punishing debt, to the hundreds of millions of people who live on less than two dollars a day, there are ghosts nearly everywhere you look in India. India is a nation of 1.2 billion, but the country's 100 richest people own assets equivalent to one-fourth of


text:
Download our free Treatwell app.
Welcome to Light Therapy central: Learn, share your experiences, read reviews, find the best deals, places and light therapy practitioners anywhere and everywhere.
Feeling kept in the dark? In order for our bodies to function properly, it's vital for us to get...
Asked by sonia10 6 years ago
Asked by andys 6 years ago
Hang on a minute – where did the sun go? One moment the weather was so glorious...more >
We're huge fans of the Vitality Show - so naturally we're pretty excited to be...more >
Is light therapy your favourite treatment? Let everyone know and see your picture here.


text:
When The Cats Away – Using NPC back stories for filler
Posted by Guest Author | Jul 27, 2016
Mini Review Monday – Chariot and Claustrophobia!
Posted by John Arcadian | Jul 25, 2016
Mini Review: Shadow of The Demon Lord and Interview With Robert J. Schwalb
by John Arcadian | Jul 29, 2016 | General
Back at Origins 2016, I got a chance to sit down and play a game of Shadow of The Demon Lord with game creator Robert J. Schwalb. I sat down to play with a few other people and after our total party kill I convinced the other players to gang up on Robert Schawlb and tag-team interview him. So,...Read More
When The Cats Away – Using NPC back stories for filler
by Guest Author | Jul 27, 2016 | General
Today's guest article is by Nick M., who talks about what to do when you can't run a full game — turn to the NPCs and play out another angle of the story. Check it out and start brainstorming what background characters are about to get an upgrade. — A Face In The Crowd John Life being...Read More
Mini Review Monday – Chariot and Claustrophobia!
by John Arcadian | Jul 25, 2016 | General
Lately, we've been getting a lot of requests for reviews of products and supplements. Doing reviews takes a decent bit of time, so we've decided to give you a small taste of what some of the things coming across our gnome sized desks are like in a Mini-review Monday. For the first...Read More
The Group You Want
by Angela Murray | Jul 22, 2016 | Game Mastering
A recent meme I saw floating around Facebook contrasted the Avengers with the Mystery Men, suggesting that the Avengers are 'what the GM hopes for', while the Mystery Men are 'what the GM actually gets'. Well, I'm going with an unpopular opinion on this: There's...Read More
Idle RPGs And Tabletop Game Time
by Matthew J. Neagley | Jul 20, 2016 | Tools for GMs
I love me a good Idle RPG. For those of you not in the know, Idle games are games that more or less play themselves with minimal intervention from the player. Progress Quest, pictured above, is a silly fantasy RPG that, once you have made your character, plays more like an operating system...Read More
Tackling The Tarrasque With 15 Rounds And A Rabbit
by John Arcadian | Jul 19, 2016 | General
As I've been getting pulled farther and farther back into the D&D 5e fold, I've taken to running more interesting concept games alongside the longer form mini-series campaigns I like to do. I've also been running a lot of games for the group of teens at the Worthington...Read More
One PC Games
by J.T. Evans | Jul 18, 2016 | Game Mastering, GMing Advice
Most groups getting around a table consist of 4-6 players (sometimes more!) and a game master. The players sometimes cycle in and out of the group, creating a strange dynamic for the game master. Then are times when groups atrophy because of people moving away, work schedules changing, or other...Read More
by John Fredericks | Jul 15, 2016 | General
When playing pretend as a kid, we always played established media characters. We were Luke Skywalker and Han Solo, Batman and Robin. We were never "generic Rebel soldier" or "Superhero who's kinda like Superman." However, in my experience, playing established...Read More
Ghostbusters: The Next Generation
by Guest Author | Jul 14, 2016 | General
Gnome Stew guest author Keith Garrett is currently celebrating 31 Days of Ghostbusters at his blog adventuresofkeithgarrett.com. He's writing posts every day to celebrate the franchise's return to the big screen (tomorrow!). He graciously decided to share not one but two with us. Check out the...Read More
It's Not The Size That Counts
(It's How You Use It)
by Senda | Jul 13, 2016 | Game Mastering
Short form games are a newer type of RPG that I find fascinating. Rather than the standard convention slot of a one shot clocking in at four hours, slipping a short game in can happen practically anywhere in nearly any amount of time. Most recently my fascination led me to experiment with...Read More
What's Gnome Stew
Written by a team of veteran Gamers and Gamemasters, Gnome Stew is a widely read gaming blog with multiple awards and close to 3,000 articles. We're dedicated to helping gamers have more fun at the gaming table. Over 2 million visitors can't be wrong!
"I check Gnome Stew every day."
— Monte Cook —
"fantastic blog for game masters, dungeon masters, and rpg fans"
— Wil Wheaton —
"If you aren't reading Gnome Stew, you're missing out."
— Wolfgang Baur —
These Might Be The Pages You Are Looking For
Keep The Stew Fires Going
Eat The Stew
Get Gnome Stew articles delivered to you via email or RSS.Click here to get our RSS feed Get Gnomes in your email with Feedburner!
Our Books For GMs
Our Books for GMs
We've published six system-neutral books for GMs, with over 28,000 copies sold. Available in print and PDF.
The Complete Game Master's Guide to Running Extraordinary Sessions
Click To Find Out More Unframed
The Art of Improvisation for Game Masters
Click To Find Out More Odyssey
The Complete Game Master's Guide to Campaign Management
Click To Find Out More Never Unprepared
The Complete Game Master's Guide to Session Prep
Click To Find Out More Masks
1,000 Memorable NPCs for Any Roleplaying Game
Click To Find Out More Eureka
501 Adventure Plots to Inspire Game Masters
Click To Find Out More
Support The Stew
Click one of these links, shop normally, and we earn a small percentage (at no cost to you).