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Eye Movement Desensitization and Reprocessing (EMDR) Scripted Protocols: Special Populationsby Marilyn Luber
View All Available Formats & Editions
Pub. Date: 08/17/2009
Publisher: Springer Publishing Company
"This excellent book contains many different scripts, applicable to a number of special populations. It takes a practical approach and walks therapists step-by-step through the EMDR therapeutic process. [Readers] will not be disappointed." Score:93, 4 stars
Praise from a practicing EMDR therapist and user of Eye Movement/i>/b>
"This excellent book contains many different scripts, applicable to a number of special populations. It takes a practical approach and walks therapists step-by-step through the EMDR therapeutic process. [Readers] will not be disappointed." Score:93, 4 stars
Praise from a practicing EMDR therapist and user of Eye Movement Desensitization and Reprocessing (EMDR) Scripted Protocols:
Kudos to...everyone who contributed to this important volume....[It] is an indispensable resource. Thank you, thank you, thank you!"
--Andrea B. Goldberg, LCSW
EMDRIA Certified EMDR Therapist
EMDRIA Consultant-in-training
This book outlines some of the basic elements of the 11-Step Standard Procedure of EMDR and the Standard Three-Pronged EMDR Protocol. Unlike other EMDR books, however, this book focuses on applying EMDR scripted protocols to special populations.
Special populations discussed include children, adolescents, couples, and clients suffering from complex posttraumatic stress disorder, dissociative disorders, anxiety, addictive behaviors, and severe pain. This is a volume rich in wisdom and insight that every EMDR clinician working with special populations will need in his or her collection.
Key topics include:
- EMDR preparation, assessment, and desensitization phases for children
- Integrating EMDR into couples therapy
- EMDR protocol for treating sexual dysfunction
- EMDR-informed treatment approaches for dissociative disorders
- Clearing the pain of unrequited love with EMDR
- An EMDR approach to treating substance abuse and addiction
- EMDR for pain patients
- Self-care for EMDR practitioners
Product Details
- 9780826122391
- Publisher:
- Springer Publishing Company
- Publication date:
- 08/17/2009
- Edition description:
- New Edition
- Pages:
- 720
- Sales rank:
- 517,803
- Product dimensions:
- 8.50(w) x 10.90(h) x 1.60(d)
Table of Contents
Part I: EMDR with Children and Adolescents
Chapter 1 The Butterfly Hug
Chapter 2 Using Olfactory Stimulation with Children to Cue the Safe or Happy Place
.Chapter 3 Using Olfactory Stimulation with Children to Cue Resource Development and Installation (RDI)
Chapter 4 Resource Connection for Children
Chapter 5 The Absorption Technique for Children
Chapter 6 The Method of Constant Installation of Present Orientation and Safety (CIPOS) for Children
Chapter 7 Footsteps Through the Maze
Chapter 8 EMDR Assessment and Desensitization Phases with Children: Step-by- Step Session Directions
Part II: EMDR and Couples
Chapter 9 Integrating EMDR into Couples Therapy
Chapter 10 From Relational Problems to Psychological Solutions: EMDR in Couples Therapy
Chapter 11 EMDR Protocol for Treating Sexual Dysfunction
Chapter 12 Infertility Protocol with EMDR
Part III: EMDR, Dissociative Disorders and Complex Posttraumatic Stress Disorder
Chapter 13 Stabilization Phase of Trauma Treatment: Introducing and Accessing the Ego State System
Chapter 14 Home Base
Chapter 15 Workplace or Conference Room
Chapter 16 Orienting the Ego State System to Present Reality (OPR)
Chapter 17 Back of the Head Scale (BHS)
Chapter 18 The Method of Constant Installation of Present Orientation and Safety (CIPOS)
Chapter 19 Installation and Transmission of Current Time and Life Orientation
Chapter 20 Height Orientation
Chapter 21 Safe Space Imagery (SSI)
Chapter 22 Installing Therapist and Therapist's Office,
and Maintaining Duality
Chapter 23 The Absorption Technique
Chapter 24 Modified Resource Development and
Installation (RDI) Procedures with Dissociative Clients
Chapter 25 Constructive Avoidance of Present Day Situations: Techniques for Managing Critical Life Issues
Chapter 26 Initial Targeting of Traumatic Material: Steps
Chapter 27 The Inverted EMDR Standard Protocol for Unstable Complex Posttraumatic Stress Disorder
Chapter 28 The Wreathing Protocol: The Imbrication of Hypnosis and EMDR in the Treatment of Dissociative Identity Disorder, Dissociative Disorder NOS and Posttraumatic Stress Disorder
Chapter 29 The "Bottom.-.Up Processing" Protocol
Chapter 30 ACT-AS-IF and ARCHITECTS Approaches to EMDR Treatment of DID
Chapter 31 An EMDR Protocol for Dissociative Identity Disorder (DID)
Chapter 32 Protocol for Releasing Stuck Negative Cognitions in Childhood Onset - Complex PTSD
Part IV: EMDR and Clients with Addictive Behaviors
Chapter 33 Dysfunctional Positive Affect: To Assist Clients with Unwanted Avoidance Defenses
Chapter 34 Dysfunctional Positive Affect: Procrastination
Chapter 35 Dysfunctional Positive Affect: To Clear the Pain of Unrequited Love
Chapter 36 Dysfunctional Positive Affect: Codependence/Obsession with Self-Defeating Behavior
Chapter 37 CravEx: An EMDR Approach to Treat
Substance Abuse and Addiction
Chapter 38 The Desensitization of Triggers and Urge Reprocessing (DeTUR) Protocol
Part V: EMDR and Clients with Pain
Chapter 39 Pain Control with EMDR
Chapter 40 EMDR Pain Protocol for Current Pain
Chapter 41 EMDR and Phantom Pain Research Protocol
Part VI: EMDR and Specific Fears
Chapter 42 EMDR and Specific Fears: The Phobia Protocol Single Traumatic Event
Part VII: EMDR and Clinician Self-Care
Chapter 43 Self-Care for EMDR Practitioners
Chapter 44 The Clinician Self - Awareness Questionnaire in EMDR
Appendix A: Worksheets
Past Memory Worksheet Scripts (Shapiro, 2001, 2006)
Present Trigger Worksheet Script
Future Template Worksheet (Shapiro, 2006)
Appendix B: Expanding the 11-step Procedure
Unconsolidated Sensory Triggers and Desensitization: Running the Tape
Script for Running the Tape to Identify and Process Unconsolidated Sensory -Triggers
Appendix C: Resources
Further Readings and Presentations
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Tuesday, January 26, 2010
Complete details, covers for After Dark Horrorfest 4 DVDs
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Electrical problem
1999 Other Dodge Models V8 Two Wheel Drive Automatic 181, 00 miles
I have1500 van with a 318 motor that I tuned up my self. I thank I got my spark plug wires mixed up.I do not understand my chilton firing order. Please help. THANKS JACKIE
Sunday, June 1st, 2008 AT 12:17 AM


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The FCC and Obscenity
This week, both the FCC and Congress are taking a new look at obscenity over the airwaves, after decades of court cases and regulation have yet to arrive at a comfortable standard of decency. Join NPR's Neal Conan and his guests for a discussion of words we can't actually say on the radio.
Frank Ahrens
*Washington Post reporter
Rep. Lamar Smith
*Republican Congressman from Texas
*Co-sponsor of bill to ban eight words/phrases from broadcast, and signer of bill to increase FCC fines
Jeremy Lipschultz
*Professor of Communications, University of Nebraska at Omaha
*Author of Free Expression in the Age of the Internet
Ted Cordes
*Former vice president in charge of broadcast standards for NBC
You must be signed in to leave a comment. Sign In / Register
Please keep your community civil. All comments must follow the NPR.org Community rules and terms of use, and will be moderated prior to posting. NPR reserves the right to use the comments we receive, in whole or in part, and to use the commenter's name and location, in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.


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Stones That Touch Your Soul!
Thank you for taking your precious time to visit my blog. What is Touch Stone Artwork? Touch Stone Artwork is my new line of rock art. I use stones of differing size and shape in a variety of artistic ways. When I look at rocks I see images in the stone. I outline what I see in each stone using the colors and textures on each rock. Touch Stone Artwork includes drawn rocks in paintings, jewelry, stone collages, and sculptures. I also do individual stones in a variety of sizes. My rock artwork uses stones from all over the world that have been lovingly collected by dear friends and myself. They come from a wide variety of interesting places. I can even take stones you have collected on your travels and turn them into artwork. Most people find that holding a stone is comforting. I have discovered that the stones themselves like to be touched and handled, hence the name; Touch Stone Artwork.
The stone on this page is a good example of how I find images in a rock. The lighter areas are natural parts of the rock's coloration. All the outlines; nose, mouth eyes , etc. were already on the stone. I simply saw the images within all the cracks and holes and made sense of them with my pen. Sometimes what I see is not a perfect picture. The dog face on top of the man's head sort of looks like a dog, but it doesn't look exactly like a dog. Sometimes I outline those shapes anyway. Often, I see multiple possible images in an area and I have to pick the image that seems to want to be drawn the most. The little girl on the top right was only a partial picture but she wanted to be outlined. I look at the rock from all angles until the rock is totally covered with pictures. The drawings seem to blend naturally into the stone. Once the rock is fully drawn it is difficult to see that I actually saw the outlines first. I never know what I will see in a rock so each rock is a one-of-a-kind piece of art. They are always a surprise to me.
I hope you enjoy what you see here at Touch Stone Artwork and , of course, I welcome your comments.
Karen Williams Smith


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Tales of ghosts and great happenings, of courage, adventure and everyday deeds. Each has its origin in a place which can still be visited, each involves people whos descendants walk the hills of Cape Breton to this day.
About the Author
A resident of Mull River, Inverness County, Cape Breton, Jim St. Clair lives on the farm established by his great-great grandparents in 1820 when they arrived from the Island of Mull. His voice is frequently heard on Then and Now, on CBCs Cape Breton Information Morning. He serves his community with love.
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Compressive sensing (CS) has been recently and enthusiastically promoted as a joint sampling and compression approach. The advantages of CS over conventional signal compression techniques are architectural: the CS encoder is made signal independent and computationally inexpensive by shifting the bulk of system complexity to the decoder. While these properties of CS allow signal acquisition and communication in some severely resource-deprived conditions that render conventional sampling and coding impossible, they are accompanied by rather disappointing rate-distortion performance. In this paper, we propose a novel coding technique that rectifies, to a certain extent, the problem of poor compression performance of CS and, at the same time, maintains the simplicity and universality of the current CS encoder design. The main innovation is a scheme of progressive fixed-rate scalar quantization with binning that enables the CS decoder to exploit hidden correlations between CS measurements, which was overlooked in the existing literature. Experimental results are presented to demonstrate the efficacy of the new CS coding technique. Encouragingly, on some test images, the new CS technique matches or even slightly outperforms JPEG.
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Company of Heroes: Tales of Valor Cheats
The trainer instance ability is buggd
jetli1269 posted on Apr 15, 2011 7:58:45 PM - Report post
Hi i notice when you use many times the same ability or use the britich 25 pounder gun howizer the recharge ability goes up and you cant use it anymore?
Edit: please fix it thanx u
Edit: please fix it thanx u
[Edited by jetli1269, 4/17/2011 3:32:41 PM]
Xex posted on Apr 26, 2011 11:14:00 AM - Report post
Hi.I got the same problem,plz can you guys fix it.Thx
CrazyBoy225 posted on Jun 10, 2011 2:09:30 PM - Report post
Hey, i also have the same problem and i'm happy that they may find out about it at last, well done guys for posting about it!
jongloek1269 posted on Nov 05, 2011 11:21:26 AM - Report post
Hi can you please fix the speciaal ability bug (example for the hoiwitzers artelery and other things like squad fire up ability if you use it a lot it will charge up now down so you cant use the ability anymore
Neo7 posted on Nov 05, 2011 11:47:29 AM - Report post
Please address problems in the main trainer topic (the red sticky topic)
Your bitterness, I will dispel
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Kim Kardashian Wore a Bedazzled Bra Through Airport Security
Also, got to keep her Balmain boots on.By Erica Schwiegershausen
Also, got to keep her Balmain boots on.By Erica Schwiegershausen
Notably, Jack O'Connell.By Véronique Hyland
Living doll.By Véronique Hyland
"Ho ho ho! Merry Christmas, grog, eggnog!"By Véronique Hyland
Bibs, sheer jumpsuits over hot pants, and so much more.By The Fug Girls
Plus: a drug-dealing grandma.By Sara Porro
Granny socks blanket the runways.By Rebecca Ramsey
Corrado Calza cooks for everyone from Giorgio Armani to Miuccia Prada.By J.J. Martin
Backpacks, buckets, and everything in between.By Veronica Misako Gledhill
Prints galore!By Rebecca Ramsey
An Italian take on post-disaster DIY.By Véronique Hyland
And some people damaged their lace espadrilles.By Véronique Hyland
Shall we call this a comeback?By Stephanie Eckardt
Enjoy!By The Cut
Pro tip: go early to Prada.By Ondine Cohane
A new exhibition examines centuries' worth of stilettos.By Erica Schwiegershausen
By Prada, naturally.By Diana Tsui
Surefire street-style bait.By Diana Tsui
Banana prints for the fellas.By Véronique Hyland
He has built the machine behind the brand.By Gaby Wood


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138 Parramatta Road, Camperdown Camperdown, NSW 205002 9557 1615
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There's been a change of the guard at The Camperdown and now generous, fresh and well-cooked fare is the order of the day. One hundred-day grain-fed beef with roast pumpkin salad; roasted salmon fillet; beer-battered flathead and char-grilled pork ribs sit alongside all the burgers, pastas and share plates you'd expect. Chicken schnitzels are huge and deliciously moist, though a parmigiana was let down by too much stringy cheese. The pastas are vegetarian with optional chicken and the same goes for the fresh and appealing caesar salad. There are $10 Sunday roasts and two-for-one meals on Thursday nights.


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Marion County courts aim to streamline jury duty system
INDIANAPOLIS - The Marion County court system is trying a new approach to improve its dismal compliance record for jury duty summons.
Of the 73 people summoned for jury duty Monday, slightly more than half reported to court. Rhonda Donahue was one of them, RTV6's Jack Rinehart reported.
"I know it's a lot of inconvenience for people. It is our duty for us to come down. I didn't want to come down but I did," Donahue said.
According to the Indianapolis Jury Pool Coordinators, more people are ignoring their jury duty summons.
During a two-year period in 2012 and 2013, jury pool records show that more than 27,000 Indianapolis residents failed to appear for jury duty, compared to the 22,600. So far in 2014, more people have ignored a jury summons over those who responded.
Hoosier Mike Meredith reported to duty as instructed Monday.
"I just think it's your duty as a citizen. And actually, this is the first time I've ever been called. But I was glad to do it," Meredith said.
By mid-October, the jury pool will begin using a California-based Interactive Voice Recording system that will allow prospective jurors to determine by phone if they're qualified for jury duty. The recording system can even be programmed for a reminder call the night before the prospective juror is required to report, Judge Gerald Zore said.
"They won't have to fill out the form and mail it back in. All they have to do is use the telephone to call in. So, I think it will be a lot more convenient for people," Zore said.
While jury duty may prove inconvenient for some, potential juror Deborah Strickland said it's a fundamental necessity for the administration of justice.
"I think it's a really important part of our democracy. And I know that if I ever was in a legal situation, I would want the opportunity to have a jury of my peers. So, I was glad to come in and do it for that reason," Strickland said.
As of now, prospective jurors will receive a summons by mail. Once they've registered by phone, the courts will have a record that they received a summons.
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It's such a common sense feature and yet so few manufacturers actually use it-- it seriously limits options when shopping.
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Khana Khazana
Visitor Information
- Opening Times
Forest Gate residents who know their curries also know that nowhere locally beats the food and ambience of Khana Khazana on Green Street, close to the Upton Park Stadium and tube station. Khana Khazana's team of chefs use authentic ingredients in their wide ranging Indian dishes to ensure full flavour, perfect taste and complete dedication to the traditions of regional Indian cookery while maintaining affordable prices. As well as all those well-known favourites, this creative kitchen offers the opportunity to try out the less usual with numerous choices that simply haven't made it to the everyday Indian menu. Equally unexpected are the Khana Khazana desserts, proof that the sweet dishes of the Subcontinent are as delicious as the savoury. Despite the traditionalism of its menu, the dining room is extremely modern, creating a relaxed and stylish look through the use of neon mood lighting, monochrome fixtures and furnishings and neutral d?cor.
LondonTown.com - Khana Khazana Location Map
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Further articles featuring Khana Khazana on LondonTown.com
Find out the best London 2016 events with our comprehensive guide to the top entertainment in the city throughout the year. From January through to December, 2016 is packed with unmissable events - so read on to get the best out of London town.
Hotels near Khana Khazana
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London > Hotels > Mid-Range Chain Hotel from £67 25% off
335 - 337 High Street, E15 | 30 minutes from Khana Khazana
The Westbridge Hotel, Stratford is a unique boutique hotel that adds a sense of style to east London. Guests can choose from standard double and twin ... More
London > Hotels > Mid-Range Chain Hotel from £63 40% off
10A Chestnut Plaza, E20 | 31 minutes from Khana Khazana
Feel at home as soon as you enter the contemporary lobby of the Holiday Inn London Stratford City. This new generation Holiday Inn is located in ... More
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196 High Street, E15 | 34 minutes from Khana Khazana
The traditional East End and the vibrant new business culture of twenty-first century London meet in Stratford. Great connections to the Docklands business parks and the ... More
Alternative Indian/South Asian restaurants nearest Khana Khazana
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268 Green Street, E7 | 2 minutes from Khana Khazana
South Indian cuisine. Vegan dishes. ... More
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London > Shopping > Specialists
30-34 Marlborough Road, E7 | 2 minutes from Khana Khazana
Fetish ... More
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278 Green Street, E7 | 2 minutes from Khana Khazana
Specialises in Gujarati and Punjabi sweets and savouries in bulk ... More
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384 Green Street, Upton Park, E13 | 5 minutes from Khana Khazana
Britain's largest pharmacy chain. Stocks prescription and over-the-counter drugs as well as a comprehensive range of health and beauty products. It also develops photographs at in-store ... More
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London > Nightlife > Pubs
47 Stratford Broadway, E15 | 25 minutes from Khana Khazana
A gastropub East End style - and that doesn't mean organic, corn-fed jellied eels and a gang of smoke ventilation engineers. The team behind King Eddie's ... More
London > Nightlife > Pubs
52-54 Celebration Avenue, E20 | 35 minutes from Khana Khazana
A 'beer shop' with all-day dining , neighbourhood in East Village is the kind of place all neighbourhoods should ... More
London > Nightlife > Pubs
116 High Road, E15 | 37 minutes from Khana Khazana
A pub with a golden palm tree and eight private heated cabanas in the garden, The Leyton Star is the revitalised ... More
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London > Business > Venue Hire
Claude Road, Plaistow, E13 | 7 minutes from Khana Khazana
... More
Also in Green Street
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Rich Helfant, executive director of the Save Lucy Committee, has one of the more unique jobs in the region: operating the world's largest artificial elephant. But the Margate native's roots in the tourism and entertainment industries date to the beginning of legal gambling in Atlantic City in 1978, and several years ago he co-founded the Greater Atlantic City GLBT Alliance to promote gay tourism.
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Liver injury is associated with inflammation, which is generally believed to accelerate the progression of liver diseases; however, clinical data show that inflammation does not always correlate with hepatocelluar damage in some patients. Investigating the cellular mechanisms underlying these events using an experimental animal model, we show that inflammation may attenuate liver necrosis induced by carbon tetrachloride (CCl4) in myeloid-specific signal transducer and activator of transcription 3 (STAT3) knockout mice. As an important anti-inflammatory signal, conditional deletion of STAT3 in myeloid cells results in markedly enhanced liver inflammation after CCl4 injection. However, these effects are also accompanied by reduced liver necrosis, correlating with elevated serum IL-6 and hepatic STAT3 activation. An additional deletion of STAT3 in hepatocytes in myeloid-specific STAT3 knockout mice restored hepatic necrosis, but decreased liver inflammation. Conclusions: Inflammation-mediated STAT3 activation attenuates hepatocellular injury induced by CCl4 in myeloid-specific STAT3 knockout mice, suggesting that inflammation associated with a predominance of hepatoprotective cytokines that activate hepatic STAT3 may reduce rather than accelerate hepatocellular damage in patients with chronic liver diseases.
Inflammation is associated with various types of acute and chronic liver diseases, and is considered a key contributor of hepatocellular damage and progression to liver fibrosis and hepatocellular carcinoma.1–7 However, clinical data show that hepatic inflammation does not always correlate with hepatocellular damage (serum ALT elevations).8–13 In order to understand the cellular mechanism of this phenomena, a well-established experimental animal model14 to study hepatotoxin-induced liver inflammation and injury induced by CCl4 was utilized in our investigation. Once CCl4 is injected, the p450 CYP2E1 in hepatocytes metabolizes it into trichloromethyl radicals (CCl3*), which then causes lipid peroxidation and membrane damage.14 These damaged hepatocytes generate free radicals, thereby activating Kupffer cells/macrophages to produce pro-inflammatory and anti-inflammatory cytokines that control the progression of liver inflammation and injury.14 Among the cytokines produced, interleukin-6 (IL-6) has been shown to be a hepatoprotective cytokine in this model15 as well as in several other liver injury models, including ischemia/reperfusion, partial hepatectomy, alcoholic and nonalcoholic fatty liver, Con A-induced T cell hepatitis.16–20 Additionally, the anti-inflammatory cytokine, IL-10, has also been shown to play an important role in controlling inflammation in CCl4-induced chronic liver injury and fibrosis, and may therefore participate in protecting the liver from disease progression.21, 22
The hepatoprotective effects of IL-6 are mediated mainly via activation of signal transducer and activator of transcription 3 (STAT3) in hepatocytes.16 In contrast, the anti-inflammatory effects of IL-10 in the liver are likely mediated via activation of STAT3 in Kupffer cells/macrophages. In general, IL-6 binds to its corresponding gp80 receptor located on hepatocytes, and induces dimerization of the gp130 signal chain. Consequently, the Janus kinases (JAKs) associated with the gp130 chains also dimerize and autophosphorylate. Once activated, the JAKs then phosphorylate gp130 to activate STAT3 monomers. Phosphorylated STAT3 then forms dimers and translocates into the nuclei to induce expression of a wide array of genes, including anti-apoptotic and anti-oxidative genes that protect against hepatocyte damage. The protective role of hepatic STAT3 has been well documented in studies with hepatocyte-specific gp130 or STAT3 knockout mice; these mice have shown to be more susceptible to hepatocellular damage induced by various toxins.23–25 Moreover, a conditional ablation of the STAT3 gene in myeloid linage cells (eg, macrophages) have shown markedly enhanced systemic and liver inflammation,26–28 which clearly suggests the anti-inflammatory functions of STAT3 in myeloid cells. In this investigation, we found that myeloid-specific STAT3 knockout (STAT3Mye−/−) mice are more susceptible to CCl4-induced liver inflammation, but are surprisingly resistant to CCl4-induced necrosis. Further study revealed that the enhanced inflammation observed is associated with elevated hepatic STAT3 activation, which may explain the reduced necrosis observed in these mice.
Eight- to 10-week old male mice were used in all experiments. Hepatocyte-specific STAT3 knockout (KO) mice (STAT3Hep−/−) and myeloid-specific STAT3 KO mice (STAT3Mye−/−)were generated as described previously.27 The STAT3Mye−/− mice were described previously as M/N-STAT3KO mice.27 The corresponding littermates of the wild-type mice were used as controls. For deletion of STAT3 in both hepatocytes and myeloid cells, STAT3Hep−/− and STAT3Mye−/− were bred to generate 4 lines of mice, including double KO (STAT3Mye−/−Hep−/−), STAT3Hep−/−, STAT3Mye−/−, and littermate wild-type controls. All mice were fed regular chow unless specified. All animal experiments were conducted in accordance with NIH guidelines and approved by the Institutional Animal Care and Use Committee of the National Institute on Alcohol Abuse and Alcoholism.
Liver injury was induced by intraperitoneal (i.p.) injection with 2 mL/kg body weight of 10% CCl4 (Sigma) dissolved in olive oil (Sigma).
Data are expressed as mean±SD. To compare values obtained from 2 groups, the Student's t test was performed. To compare values obtained from three or more groups, 1-factor analysis of variance (ANOVA) was used, followed by Tukey's post hoc test. Statistical significance was taken at the P <0.05 level.
all other methods are described in the supporting documents.
As shown in Figs. 1A–C, treatment of wild-type littermate control mice with CCl4 induced serum ALT elevation, liver necrosis, and inflammation with peak effect occurring 24 hours post injection. Compared with wild-type mice, STAT3Mye−/− mice had greater inflammatory cell infiltration around the hepatic central vein, but surprisingly, these mice had lower serum ALT levels and less liver necrosis (Figs. 1A–C). TUNEL assay results revealed that the number of apoptotic hepatocytes was significantly lower in STAT3Mye−/− mice than in wild-type mice 24 hours post CCl4 injection (Fig. 1D).
Immunohistochemical analyses with anti-MPO staining showed that the majority of cells infiltrating the liver after CCl4 injection were neutrophils (Fig. 2A). These neutrophils are either located within sinusoids or infiltrated into liver parenchyma (Fig. 2A and Fig. S1a). The number of MPO+ neutrophils was much higher in STAT3Mye−/− mice compared with wild-type mice post CCl4 injection. Flow cytometry analyses of liver inflammatory cells showed that the percentage and total number of neutrophils (CD11b+Gr-1bright cells) in the liver were significantly higher in STAT3Mye−/− mice than in wild-type mice before or 24 hours post CCl4 injection (Figs. 2B–D). Lee et al previously demonstrated that STAT3-deficient neutrophils matured normally and were functional.29 Here we also confirmed that nutrophils from wild-type and STAT3Mye−/− mice had similar respiratory burst (Fig. S1c).
Fig. 3A shows that basal levels of various hepatic inflammatory cytokines and chemokines were higher in STAT3Mye−/− mice compared with wild-type mice. In wild-type mice, treatment with CCl4 increased the expression of these cytokines and chemokines; however, this increase was much more profound in STAT3Mye−/− mice. Serum levels of several inflammatory cytokines were also found to be elevated after CCl4 injection, and again, these serum elevations were higher in STAT3Mye−/− mice compared with wild-type mice (Fig. 3B). Serum IL-12p70 and IL-10 were below detection levels in both groups (data not shown).
Since p450 CYP2E1-mediated CCl4 metabolism is essential for CCl4-induced liver injury,14 we examined whether alterations in CCl4 metabolism are responsible for reduced liver injury in STAT3Mye−/− mice. As shown in Fig. 4A and Fig. S1b, the basal levels of CYP2E1 expression were comparable in livers from wild-type and STAT3Mye−/− mice. After CCl4 administration, CYP2E1 expression was downregulated in both groups of STAT3Mye−/− and wild-type mice. The downregulation seemed to be more profound in the former group compared to the later group, suggesting that CCl4 metabolism is not reduced in STAT3Mye−/− mice compared to wild-type mice since the downregulation of CYP2E1 is caused by CCl4 metabolism.
Injection of CCl4 induced increased oxidative stress, which was higher in STAT3Mye−/− mice than in wild-type mice as determined by measuring HNE-His adduct (Fig. 4B). Although STAT3Mye−/− mice had higher levels of oxidative stress, CCl4 treatment-induced GSH depletion, which was observed in wild-type mice, was not observed in STAT3Mye−/− mice (Fig. 4B). At the present, it is not clear why STAT3Mye−/− mice had higher levels of oxidative stress without GSH depletion after CCl4 treatment compared to wild-type mice. It is possible that elevated inflammation may trigger some compensatory effects to prevent GSH depletion in STAT3Mye−/− mice, which should be explored in the future studies.
To understand the mechanism by which STAT3Mye−/− mice are resistant to CCl4-induced liver injury, we measured activation of hepatic STAT3, a signaling molecule that has been shown to promote hepatocyte survival in the liver.23–25 Shown in Fig. 4A, basal STAT3 activation (pSTAT3) was higher in STAT3Mye−/− mice than in wild-type mice. Injection with CCl4 induced much higher and prolonged STAT3 activation in STAT3Mye−/− mice compared with wild-type mice. Expression of STAT3 protein was also slightly higher in STAT3Mye−/− mice than in wild-type mice, while expression of STAT1 protein was comparable between these groups. Fig. 4A shows that the basal levels (0 h time point) of hepatic pSTAT3 are higher in STAT3Mye−/− mice than wild-type mice. Our previous study showed that STAT3Mye−/− mice had similar basal levels of hepatic pSTAT3 compared to wild-type mice (Fig. 2C in Reference 28). The discrepancy between our current and previous studies was likely due to the mice fed regular chow in the current study and a medicated diet in our previous study. Fig. S2a confirmed that feeding with a medicated diet abolished the basal levels of hepatic pSTAT3 in STAT3Mye−/− mice. Despite the diminished basal levels of hepatic pSTAT3 activation after feeding with a medicated diet, STAT3Mye−/− mice were still resistant to CCl4-induced liver injury (elevation of serum ALT/AST) (Fig. S2b). In addition, the basal levels of p38 MAPK were higher in the liver of STAT3Mye−/− mice compared to wild-type mice, while activation of ERK in the liver was lower in STAT3Mye−/− mice than in wild-type mice (Fig. S3). Activation of phospho-NF-κB p65 was higher in the liver of STAT3Mye−/− mice compared to wild-type mice after CCl4 injection (Fig. S3).
To understand the mechanisms underlying elevated hepatic STAT3 activation in STAT3Mye−/− mice, the production and expression of several cytokines (IL-6, IL-22, and oncostatin M [OSM]) and growth factors (HGF, EGF), which stimulate STAT3 activation in hepatocytes, were examined in Kupffer cells. As shown in Figs. 4C and D, the production and expression of IL-6 were markedly higher in Kupffer cells from STAT3Mye−/− mice than from wild-type mice with or without LPS stimulation. Expression of OSM was also higher, to a lesser extent, in STAT3Mye−/− Kupffer cells than in wild-type cells. Expressions of IL-22 and HGF were comparable between these two types of cells (Fig. 4D) while expression of EGF was undetectable in Kupffer cells (data not shown). In addition, STAT3Mye−/− Kupffer cells produced higher levels of IL-10, TNF-α, and IFN-γ compared to wild-type Kupffer cells with or without LPS stimulation. Finally, IL-6 neutralizing antibody significantly diminished pSTAT3 levels in the liver of STAT3Mye−/− mice (Fig. 4E).
Since STAT3 has been shown to play an important role in hepatoprotection in several murine models of liver injury,23–25 we hypothesized that increased STAT3 activation in the liver of STAT3Mye−/− mice may contribute to the reduced necrosis found in these mice after CCl4 injection. To test this hypothesis, we used hepatocyte-specific STAT3 knockout (STAT3Hep−/−) mice to first examine whether STAT3 in hepatocytes protects against CCl4-induced liver injury. As illustrated in Fig. 5A–C, CCl4 injection induced greater liver damage in STAT3Hep−/− mice than in wild-type mice, as evidenced by increased serum ALT levels, and more severe necrosis and apoptosis. Additionally, injection of CCl4 induced more profound GSH depletion in STAT3Hep−/− mice compared with wild-type mice (Fig. 5D). Although STAT3Hep−/− mice had more liver necrosis, the expression of inflammatory cell markers (eg, CCR2 and F4/80) and pro-inflammatory cytokines (eg, TNF-α, IL-6, MIP-2, and ICAM-1) were lower in these mice compared with wild-type mice (Fig. 5E–F, Fig. 6A). Serum TNF-α and IL-6 levels were slightly higher in STAT3Hep−/− mice than in wild-type mice 24 hours post CCl4 injection (Fig. 6B).
To test the hypothesis that the resistance of STAT3Mye−/− mice to CCl4-induced liver injury is caused by enhanced STAT3 activation in hepatocytes, we deleted STAT3 from the hepatocytes of STAT3Mye−/− mice by generating hepatocyte and macrophage/neutrophil specific double KO (STAT3Mye−/−Hep−/− double KO). Double KO mice showed greater ALT elevation and more necrosis at 24 hours than STAT3Mye−/− mice (Figs. 7A–C). Regarding liver inflammation, double KO mice showed significantly lower expression of MPO and CCR2 at, respectively, 24 and 12 hours post CCl4 injection, compared with STAT3Mye−/− mice, (Figs. 7D and 7E). Expression of F4/80 was comparable between STAT3Mye−/− mice and double KO mice.
Hepatic expression of several cytokines (TNF-α, IL-1β, IFN-γ) and chemokines (MIP2, MCP-1, ICAM1) and serum levels of pro-inflammatory cytokines (TNF-α and IL-6) were lower in double KO than in STAT3Mye−/− mice 12 hours post CCl4 injection (Fig. 8).
In this paper, we reported a model of STAT3Mye−/− mice in which inflammation does not correlate with hepatocellular injury induced by CCl4 and whereby inflammation-associated hepatic STAT3 activation reduces liver necrosis (see summarized Fig. 8C). This may help explain a lack of correlation between inflammation and hepatocellular damage (serum ALT levels) observed in some patients with chronic liver diseases.8–13
In our study, injection with CCl4 induced much higher levels of systemic and hepatic inflammation in STAT3Mye−/− mice than in wild-type mice, suggesting that STAT3 in myeloid cells plays an important role in inhibiting inflammation in a model of CCl4-induced liver injury. This is consistent with previously well-documented studies showing that the anti-inflammatory effects of STAT3 in myeloid cells using various models of organ injury.26–28 Surprisingly, despite higher levels of inflammation in STAT3Mye−/− mice, they had much lower serum ALT levels and less liver necrosis than wild-type mice after CCl4 administration. The resistance of STAT3Mye−/− mice to CCl4-induced liver necrosis may be due to either the impaired ability of STAT3-deficient neutrophils/macrophages to induce hepatocellular damage or to the resistance of hepatocytes to CCl4-induced hepatocellular damage in STAT3Mye−/− mice. Several lines of evidence suggest that it is the second mechanism that contributes to reducing liver necrosis in STAT3Mye−/− mice due to enhanced STAT3 activation in the liver (see discussion below).
The hepatotoxicity of CCl4 is mediated by the direct induction of hepatocyte damage and indirect activation of Kupffer cells/macrophages and neutrophils.14 Activated Kupffer cells/macrophages produce free radicals and pro-inflammatory cytokines such as TNF-α that further trigger hepatocellular damage and induce neutrophil accumulation and activation.2, 5 Activated neutrophils can cause hepatocyte damage via releasing oxygen species and proteases.2, 5 We have previously shown that Kupffer cells from STAT3Mye−/− mice produce much higher levels of reactive oxygen species and TNF-α compared with those from wild-type mice.27 By using four different assays, Lee et al previously demonstrated that STAT3-deficient neutrophils mature normally and are functional.29 In the present study we also confirmed that STAT3-deficient neutrophils from STAT3Mye−/− mice are functional in vitro because they produced similar respiratory burst after PMA stimulation compared to PMA-stimulated wild-type mouse neutrophils (Fig. S1c). Moreover, an additional deletion of STAT3 in hepatocytes restored liver necrosis in STAT3Mye−/− mice after CCl4 administration, suggesting that neutrophils from STAT3Mye−/− mice are functional in vivo. Collectively, these findings suggest that STAT3-deficient macrophages and neutrophils in STAT3Mye−/− mice have normal ability to induce inflammatory responses and hepatocellular damage; and that the reduced liver necrosis observed in STAT3Mye−/− mice is not due to a defect in STAT3-deficient macrophages and neutrophils to induce hepatocellular damage.
The hepatoprotective effect of hepatic STAT3 has been well documented in various models of liver injury,23–25 which is further confirmed in our study using an experimental model of CCl4-induced liver damage (Fig. 5). This suggests that elevated liver STAT3 activation in STAT3Mye−/− mice likely contributes to the resistance of these mice to CCl4-induced liver necrosis and oxidative stress. This concept is further supported by conclusive evidence showing that deletion of STAT3 in hepatocytes restores liver necrosis in STAT3Mye−/− mice after CCl4administration (Fig. 7). Interestingly, STAT3Mye−/− mice are resistant to CCl4-induced liver necrosis as demonstrated in the current study but more susceptible to Con A-induced T cell hepatitis despite of enhanced STAT3 activation in the liver (Fig. 2 in Reference 28). This discrepancy could be due to the deletion of STAT3 in myeloid cells preferentially enhancing the Th1 cytokine (IFN-γ) response during Con A-induced T cell hepatitis, dominating over the hepatoprotective effect of STAT3 and resulting in accelerated liver injury in this model.28 Such preferential induction of IFN-γ was not observed in STAT3Mye−/−mice in the CCl4-induced liver injury model (2500 pg/ml serum IFN-γ in Con A model28 vs. 25 pg/ml IFN-γ in CCl4 model in STAT3Mye−/− mice in the current study). In addition, STAT3Mye−/− mice are also more susceptible to chronic ethanol feeding-induced liver inflammation and injury.27 It has been well documented that chronic ethanol consumption inhibits STAT3 activation in the liver.30 Therefore, it is probable that chronic ethanol feeding diminishes hepatic STAT3 activation and abolishes the hepatoprotective effect of STAT3 in STAT3Mye−/− mice, resulting in enhanced liver injury in this alcohol-induced liver injury model.27
We have previously shown that STAT3 activation in hepatocytes promotes liver inflammation in alcohol-induced liver injury.27 Our findings in present studies showed that STAT3 activation in hepatocytes also play a pro-inflammatory role in CCl4-induced liver injury because deletion of STAT3 reduced systemic and hepatic inflammation although enhanced CCl4-induced liver damage (Fig. 5). In addition, an additional deletion of STAT3 in hepatocytes enhanced CCl4-induced liver necrosis but partially counteracted the strong inflammation in STAT3Mye−/− mice after CCl4 administration (Fig. 8). This is probably because deletion of STAT3 in hepatocytes reduced the hepatic expression of several STAT3-controlled inflammatory mediators (such as complement 3/5, IL-1, MIP-2, MCP-1, and ICAM-1) in STAT3Mye−/− mice (Fig. 7). Taken together, these findings suggest that enhanced hepatocellular STAT3 activation in STAT3Mye−/− mice may contribute to not only the reduced liver necrosis but also the enhanced inflammation after CCl4 administration in these mice. In addition, elevated NF-κB activation (Fig. S3) may also contribute to the reduced necrosis in STAT3Mye−/− mice because of the hepatoprotective functions of NFκB.
With respect to what factors are responsible for enhanced STAT3 activation in the liver of STAT3Mye−/− mice (Fig. 4A), many cytokines and growth factors including IL-6, IL-6 family cytokines (such as OSM, IL-11, cardiotrophin-1, CNTF-1, LIF), IL-22, EGF, and HGF have been shown to stimulate STAT3 in the liver.16, 31–33 Here, we provided several lines of evidence suggesting that IL-6 is an important factor responsible for the higher levels of pSTAT3 in the liver of STAT3Mye−/− mice compared to wild-type mice. First, the basal levels of serum and hepatic IL-6 were higher in STAT3Mye−/− mice than in wild-type mice, which is consistent with previous reports.27 Second, Kupffer cells from STAT3Mye−/− mice produced much higher levels of IL-6 than wild-type Kupffer cells (200–500 pg/ml from STAT3Mye−/− vs.10 pg/ml from wild-type mice) (Fig. 4C). Finally, blockage of IL-6 with a neutralizing antibody diminished the basal levels of pSTAT3 in the liver of STAT3Mye−/− mice (Fig. 4E). In addition, OSM may also contribute, to a lesser extent, to the enhanced pSTAT3 in the liver of STAT3Mye−/− mice because Kupffer cells from these mice expressed higher levels of OSM compared to wild-type cells (Fig. 4D).
In general, it is believed that inflammation plays a key role in contributing to the progression of liver diseases;1–6 however, many studies have reported that inflammation does not always correlate with hepatocellular damage in patients with chronic liver diseases.8–13 Based on the findings from this and other previous studies, we speculate that inflammation associated with a predominance of hepatoprotective cytokines such as IL-6, IL-6-related cytokines, and IL-22 may not correlate with hepatocellular damage, while inflammation with a predominant expression of Th1 cytokines (such as IFN-γ) may be closely associated with liver injury. Indeed, the downstream targets of IFN-γ, such as STAT1 and IP-10, have been shown to correlate with hepatocellular damage in patients with viral hepatitis C infection.34 Thus, understanding the effects of different types of liver inflammation on hepatocellular damage may help us design better strategies to treat patients with chronic liver diseases.
This work was supported by the intramural program of National Institute on Alcohol Abuse and Alcoholism, NIH. Dr. Norio Horiguchi was supported partially by the Japan Society for the Promotion of Science (JSPS) award at NIH.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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4-Year-Old Channels Michael Jackson on Ellen
Earlier this afternoon, four-year-old hip-hop dancer Miles Brown appeared on Ellen, where he explained that he doesn't like that his dancing makes people happy. That's too bad, because his adorable performance certainly put smiles on our faces. Clip at left.
Man Baby Vs. Machine
Loose Lips
Noted guyliner enthusiast Pete Wentz has gone up in our estimation. He says that the members of Fall Out Boy are "liberal Democrats from the suburbs of Chicago," and that his parents met when they were working on a Joe Biden campaign!!! Cute. • Oh good God, not sure if this is awesome or awful: a virtual Heidi Montag…


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Donald L. Monahan RitesMay 21,2013Donald L. Monahan Rites
A graveside service for Donald L. Monahan, 69, who died May 16, 2013, at his home in Rutland was held Monday, May 20, in East Clarendon Cemetery.
Officiating was the Rev. Thomas Houle, pastor of St. Peters Church.
Speakers were Tyler Ross, Savannah Ross, Austin Ross and Kassidy Ross.
Military honors were provided by Rutland American Legion Post 31. Flag folders were John Manney, Sam Coburn and Ron Fairbanks. Jim Burke presented the flag to the family. Taps was sounded by Jim Mills.
Arrangements were under the direction of the Clifford Funeral Home.MORE IN ObituariesCynthia M. Full StoryMarion Turner
Marion Turner, 93, of Rutland, died Sunday, July 24, 2016, at Mountain... Full StoryThelma Alex
SPRINGFIELD Thelma Alex, 95, passed away Thursday, July 21, 2016, in... Full Story
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Sea ducks in rough water…
By BirdLife Europe, 13 Jul 2012
- Pelican hotline
- BirdLife cries the loss of conservation giant Luc Hoffmann
- Winning hearts and minds in Cape Verde
- Traditional wisdom and conservation science in Lake Victoria
- School's out(side) for Spring!
- Shea butter nourishes more than dry skin
- Croatian national powerlines operator to collaborate with BirdLife Partner to protect migratory birds
- Malta's first marine Special Protection Areas announced
- Spix's Macaw reappears in Brazil
- New initiative aims to make self-assessment easier for conservation
The 2012 IUCN Red List for birds released by BirdLife International gave a strong warning message that the risk of extinction has increased substantially for nearly 100 species of Amazonian birds. What are the results for Europe?
Detailed surveys in the Baltic Sea for the period 2007-2009 revealed that almost 3 million Long-tailed Ducks Clangula hyemalis have disappeared from the Baltic Sea since the previous survey in 1992-1993. This sharp decline in numbers resulted in the species being uplisted to Vulnerable. The Steller's Eider Polysticta stelleri was already listed as Vulnerable but has decreased by 66% in the Baltic Sea, while the fortunes of another sea duck, the Velvet Scoter Melanitta fusca are even worse, with the species now being listed as Endangered. Overall, the numbers of sea duck species wintering in the Baltic Sea have declined by about 60%.
As these sea ducks feed on bivalves (like mussels, clams and oysters, whose populations are also declining and changing in size and distribution), ecosystem changes and global warming are plausible causes. Factors such as predation, diseases and nutritional deficiencies are also present. But the direct threats identified are caused by human activities, eg degradation of the seafloor life caused by fishing as well as oil pollution, bycatch in fisheries, hunting and pollution by hazardous chemicals. Not all of these factors are the ultimate reason for the decline but their cumulative effect and the fact that they can be contained by targeted management and legislation makes them important for consideration. Read more on http://seaducks.hgo.se/
Unfortunately this was not the only bad news about our European breeding birds. The Saker Falcon Falco cherrug was uplisted to Endangered because a revised population trend analysis indicates that it may be undergoing a very rapid decline. This negative trend is a result of unsustainable capture for the falconry trade, as well as habitat degradation and the impacts of agrochemicals, and the rate of decline appears to be particularly severe in Central Asian breeding grounds. The status revision is based on careful review of the latest available evidence from across the range but the situation is dynamic with still large gaps in the information to be filled.
Surveys are urgently needed to produce more robust and less uncertain population estimates, in particular for China, Russia and Mongolia. Yelkouan Shearwater Puffinus yelkouan , which breeds only in the central and western Mediterranean, was uplisted to Vulnerable as it is estimated to be undergoing a rapid population decline, caused by extremely low breeding success and adult survival owing to fisheries bycatch and predation by introduced mammals. Another European endemic, Rock Partridge Alectoris graeca was uplisted to Near Threatened since the species is likely to be undergoing a moderately rapid population reduction owing to habitat degradation and hybridization in some areas of its range, which is limited to Sicily, Italy, the Alps and Balkans. The involvement of BirdLife Europe doesn't stop at collecting the scientific data for the Red List. We are now promoting the further development and implementation of the species action plans and a better protection for the biodiversity of the Baltic Sea. For more information please contact Willem Van Den Bossche, EU Conservation Officer at BirdLife Europe


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The Media show - why aren't there more female experts on media shows?(7 Posts)
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Yacon Syrup: The Facts Behind The Latest "Weight Loss" Fad
Photo: Courtesy Of Whole Foods.
Every year around this time, a new so-called "miracle" superfood or supplement makes the rounds, promising a bangin' bikini bod in mere seconds — or something. And, guys, this year's no different. With an endorsement from the inescapable Dr. Oz, the Internet's hottest weight-loss supplement is undoubtedly yacon syrup, a mysterious sweet concoction from the Andes.
Actually, to be fair, while "miracle" is definitely a stretch, there might be a lot to like about yacon (or yacón, as it's known in Peru). Using a method similar to that used to make maple syrup, the thick, molasses-like substance is extracted from the roots of the yacón plant; both the roots and the leaves of the plant are used in countries like Brazil and Bolivia for their purported healing properties.
But, the buzzy part comes courtesy of a compound called fructooligosaccharides, or FOSs, which supposedly helps people feel full while being naturally low in calories (since they're not fully digested before they get through your bowels). It's also full of fiber, which helps regulate your blood-glucose levels. And, thanks to a small study from back in 2009, these FOSs have a reputation for contributing to significant weight loss.
Of course, as with any product that claims rapid weight loss just by ingesting a seemingly magical ingredient, a serious dose of skepticism is required here. Very little research exists on the effectiveness of yacón syrup, even as a healthy supplement to your diet; even the lead author in the study above urged caution, pointing out that those who lost weight with yacón syrup also cut their regular caloric intake — and quickly gained the weight back. And, as Shira Lenchewski, a registered nutritionist based in New York and L.A., points out, "because yacón passes through the intestines largely undigested, it can be harsh on the GI tract, especially in people with inflammatory bowel conditions, and may cause gas."
Still, we think there might be some redeeming qualities about yacón that outweigh the hype. As Lenchewski points out, "FOSs are considered prebiotics, non-digestible carbohydrates that act as food for healthy gut bacteria. And, since gut health translates to overall health, a robust flora ecosystem is essential for preventing inflammation and boosting intestinal immunity." And, depending on how the economics work out, yacón could prove to be an effective, affordable substitute for artificial low-calorie sweeteners like aspartame and Splenda. Just don't expect any "miracles," yeah? You guys know better than that.
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- Wellness | Yacon Syrup Facts - Weight Loss, Low-Calorie Sweetener
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The combination of cloud computing and big data is a match made in heaven. Big data requires a flexible compute environment, which can scale quickly and automatically to support massive amounts of data. Infrastructure clouds provide exactly that. But whenever cloud computing is discussed, the question comes up:
What about cloud security for big data?
When it comes to cloud security in a big data use case, the expectation is that any security solution will provide the same flexibility as the cloud without compromising the overall security of the implementation. When taking your big data to the cloud, the following four tips will enable you to achieve cloud flexibility paired with strict cloud security.
1. Encrypt sensitive data (seriously)
Data encryption creates the "virtual walls" for your cloud infrastructure. Deploying cloud encryption is considered a fundamental first step, but there is no solution with a "one size fits all" approach. Some encryption solutions require on premise gateway encryption, which does not work well in cloud big-data scenarios. Other approaches (for example, data encryption powered by the cloud provider itself) force the end user to trust someone else with the encryption keys, which is both risky and a compliance deal-breaker.
Recent encryption technologies, like split-key encryption, are tailored specifically to the cloud and leverage the best of both worlds by providing an infrastructure cloud solution while keeping the encryption keys safe and in the hands of the customer.
To achieve the best possible encryption for your big data scenario, use split-key encryption.
2. Look for cloud security solutions that can architecturally scale
In big data, each component of the architecture should scale, and the cloud security solution is no different. When selecting a cloud security solution, make sure it is available across all relevant cloud geo-locations. Furthermore, it must scale effectively with your big data infrastructure.
On the surface level, this means, of course, that hardware cannot be involved. Hardware Security Modules (HSMs) do not fit the big data use case because of the inability to scale and flex to fit the cloud model.
To achieve the necessary scalability, use a cloud security solution that is designed for the cloud, but achieves security that is comparable to (or better than) hardware-based solutions.
3. Automate as much as possible
Big data cloud computers are frustrated from the fact that their cloud security architecture does not easily scale (see tip #2). Traditional encryption solutions require an HSM (hardware) element. Needless to say, hardware implementation cannot be automated.
To be able to automate as much of your cloud security as possible, strive for a virtual appliance approach, not a hardware approach. Also, make sure that a usable API (ideally a RESTful API) is available as part of the cloud security offering.
A virtual appliance plus RESTful API will enable the required flexibility and automation needed in a cloud big data use case.
4. Do not compromise on data security
Because cloud security is often complicated, we see "security shortcuts" in big data implementations. Security shortcuts are usually taken to avoid complexity and maintain the big data architecture "unharmed."
Some customers use freeware encryption tools and keep the encryption key on disk (which is highly insecure and may expose the encrypted data to anyone with access to the virtual disk), while others simply do not encrypt. These shortcuts are certainly not complicated, but, obviously, they are also not secure.
When it comes to big data security, map your data according to its sensitivity and protect it accordingly. In some cases, the consequences are dramatic. Not all big data infrastructure is secure, and one might need to find an alternative, if the data at stake is regulated or sensitive.
Cloud security for big data is available
Big data can continue to enjoy the scalability, flexibility, and automation offered by cloud computing while maintaining the strictest security standards for the data. Encryption is considered a fundamental first step in protecting cloud (big) data, and new technologies such as split-key encryption and homomorphic key management should be leveraged to protect sensitive data and comply with regulations like HIPAA, PCI, and many others.
The post 4 Great Tips: Cloud Security for Big Data appeared first on Porticor Cloud Security.
Read the original blog entry...
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with the 19th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world and ThingsExpo Silicon Valley Call for Papers is now open.
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The IoT is changing the way enterprises conduct business. In his session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, discussed how businesses can gain an edge over competitors by empowering consumers to take control through IoT. He cited examples such as a Washington, D.C.-based sports club that leveraged IoT and the cloud to develop a comprehensive booking system. He also highlighted how IoT can revitalize and restore outdated business models, making them profitable ...
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Big Data engines are powering a lot of service businesses right now. Data is collected from users from wearable technologies, web behaviors, purchase behavior as well as several arbitrary data points we'd never think of. The demand for faster and bigger engines to crunch and serve up the data to services is growing exponentially. You see a LOT of correlation between "Cloud" and "Big Data" but on Big Data and "Hybrid," where hybrid hosting is the sanest approach to the Big Data Infrastructure pro...
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Jul. 25, 2016 07:15 PM EDT Reads: 1,794
We all know the latest numbers: Gartner, Inc. forecasts that 6.4 billion connected things will be in use worldwide in 2016, up 30 percent from last year, and will reach 20.8 billion by 2020. We're rapidly approaching a data production of 40 zettabytes a day – more than we can every physically store, and exabytes and yottabytes are just around the corner. For many that's a good sign, as data has been proven to equal money – IF it's ingested, integrated, and analyzed fast enough. Without real-ti...
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I wanted to gather all of my Internet of Things (IOT) blogs into a single blog (that I could later use with my University of San Francisco (USF) Big Data "MBA" course). However as I started to pull these blogs together, I realized that my IOT discussion lacked a vision; it lacked an end point towards which an organization could drive their IOT envisioning, proof of value, app dev, data engineering and data science efforts. And I think that the IOT end point is really quite simple…
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A critical component of any IoT project is what to do with all the data being generated. This data needs to be captured, processed, structured, and stored in a way to facilitate different kinds of queries. Traditional data warehouse and analytical systems are mature technologies that can be used to handle certain kinds of queries, but they are not always well suited to many problems, particularly when there is a need for real-time insights.
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We're entering the post-smartphone era, where wearable gadgets from watches and fitness bands to glasses and health aids will power the next technological revolution. With mass adoption of wearable devices comes a new data ecosystem that must be protected. Wearables open new pathways that facilitate the tracking, sharing and storing of consumers' personal health, location and daily activity data. Consumers have some idea of the data these devices capture, but most don't realize how revealing and...
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WebRTC is bringing significant change to the communications landscape that will bridge the worlds of web and telephony, making the Internet the new standard for communications. Cloud9 took the road less traveled and used WebRTC to create a downloadable enterprise-grade communications platform that is changing the communication dynamic in the financial sector. In his session at @ThingsExpo, Leo Papadopoulos, CTO of Cloud9, discussed the importance of WebRTC and how it enables companies to focus...
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Is your aging software platform suffering from technical debt while the market changes and demands new solutions at a faster clip? It's a bold move, but you might consider walking away from your core platform and starting fresh. ReadyTalk did exactly that. In his General Session at 19th Cloud Expo, Michael Chambliss, Head of Engineering at ReadyTalk, will discuss why and how ReadyTalk diverted from healthy revenue and over a decade of audio conferencing product development to start an innovati...
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Early adopters of IoT viewed it mainly as a different term for machine-to-machine connectivity or M2M. This is understandable since a prerequisite for any IoT solution is the ability to collect and aggregate device data, which is most often presented in a dashboard. The problem is that viewing data in a dashboard requires a human to interpret the results and take manual action, which doesn't scale to the needs of IoT.
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IoT generates lots of temporal data. But how do you unlock its value? You need to discover patterns that are repeatable in vast quantities of data, understand their meaning, and implement scalable monitoring across multiple data streams in order to monetize the discoveries and insights. Motif discovery and deep learning platforms are emerging to visualize sensor data, to search for patterns and to build application that can monitor real time streams efficiently. In his session at @ThingsExpo, ...
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Verizon Communications Inc. (NYSE, Nasdaq: VZ) and Yahoo! Inc. (Nasdaq: YHOO) have entered into a definitive agreement under which Verizon will acquire Yahoo's operating business for approximately $4.83 billion in cash, subject to customary closing adjustments. Yahoo informs, connects and entertains a global audience of more than 1 billion monthly active users** -- including 600 million monthly active mobile users*** through its search, communications and digital content products. Yahoo also co...
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Kendal MRT Members' Epic Roundby Dan Bailey - UKHillwalking.com Nov/2012
This news story has been read 935 times
Over Friday 16th and Saturday 17th November two members of Kendal Mountain Rescue Team took on a massive 180km route through the Howgills and eastern Lakeland to raise funds for the team.
Deputy Team Leaders Dave Howarth and Kath Jackson travelled around the perimeter of the team's operational boundary - a total distance of 90km (56 miles) cycling, 80km (50 miles) mountain walking/running and 10km (6 miles) of kayaking.
'The challenge started at 8:30pm Friday evening at the Endurance session at the Kendal Mountain Festival, where the sell out crowd cheered us on our way' Kath told us.
'Onto road bikes for a 50km ride taking us to the coast at Silverdale and across to Kirkby Lonsdale and Barbon. Here we went on foot over the Howgills, seeing in Calf Top before dropping to Sedbergh and climbing back out over Arant Haw and The Calf. At Carlingill we took to mountain bikes for a quick whizz up to Low Borrowdale farm before we were back on foot with a climb onto Wintercleugh and Whinash. A grey dawn saw us on the summit of the A6 eating bacon sandwiches from "Big Nige" (our friend Dave's campervan!).'
'Sore by now but cheered by a day getting clearer and brighter all the time we took in Yarlside and Harrop Pike, Gatesgarth pass and Harter Fell. Dave took in our optional out-and-back to Kentmere Pike whilst I dropped straight to Nan Bield before climbing back to our high point: High Street summit. Thornthwaite Beacon, Ill Bell, Froswick and Yoke took their toll physically but we were rewarded with magnificent views of the whole route and beyond. A painful trudge down the Garburn pass saw us at Dubbs reservoir where getting on the mountain bikes again for the short ride to Windermere was a huge relief.'
'At Windermere Canoe and Kayak's boathouse we took to the lake in sea kayaks and paddled south as the light faded. We were blessed with a clear, still night and a beautiful moonlight paddle to Newby Bridge. All that remained was 40 kilometres of road biking back to Kendal, although it did have a sting in the tail with the hillclimb over Scout Scar right at the end!'
'We got an overwhelming reception from the team back in Kendal and were welcomed on stage at the Mountain Festival's bike night to say a few words and receive champagne before they let us go to bed! Total time was 24 hours and 7 minutes.'
Check out their frankly rather impressive route on Viewranger here.
And to make a donation visit the dedicated fundraising page here.
To mark Finland's centenary next year, moves are afoot in Norway to donate a remote summit to its less... Read more
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A tourism campaign was launched yesterday with the (temporary) installation of giant mirrored letters spelling the word EPIC at... Read more
Despite challenging weather - with marquees blowing across Crow Park - landscape charity Friends of the Lake District's Keswick... Read more
Edit: 09/05/16 - He has been found safe and well Police have appealed for leads on the whereabouts of a... Read more
A brand new walking route has been completed in the north Lakes. The Ullswater Way, which makes a 20-mile... Read more


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Miranda Kerr
Miranda Kerr in Nobody Denim Cult Skinny Jeans in Addict
When I saw these photos, my first thought was 'wow, how amazing does Miranda Kerr look?' and I don't even mean the whole outfit, just the way her Nobody Denim Cult Skinny jeans in Addict fit her is perfect!
Miranda was dropping off her friend in Beverly Hills, California after attending a photo shoot earlier in the day in these photos. I honestly think she can do no wrong when it comes to fashion. She could go out wearing a trash bag and make it look incredible. Her legs are the perfect shape and length for jeans as well. I have yet to see a badly fitting pair on her! Do you love Miranda's denim style too?
Images courtesy of JP/JFXimages/WENN.com.
Miranda Kerr in Frame Le Skinny Jeans
How cute are Miranda Kerr and Orlando Bloom? Orlando was seen picking up Miranda from a spa appointment and even got out and opened the car door for her!
Miranda wore her Frame Le Skinny jeans with a blazer and loafers. Frame seems to be Miranda's go to brand lately, as we've seen her in a couple of different pairs over the past few weeks. Although the brand is still really new, I do think it'll gain a strong celebrity following since they are really flattering and have some great washes. You can buy these jeans online from Net-A-Porter for $189.
Miranda Kerr in Frame Denim Le Skinny Jeans in Redchurch Street
Miranda Kerr wore a pair of Frame Denim Le Skinny jeans in Redchurch Street while visiting a friend's house for a Christmas party with her family.
While this is a more casual outfit for Miranda's, I think the light wash of the jeans looks really nice with the yellow sweater and her leopard shoes add a nice touch. You can view all of Miranda's outfits from the year and vote for your favorite outfit of her's here and you can buy these jeans online here.
Images from INFDaily.com
Favorite Celeb Outfit: Miranda Kerr
Miranda Kerr has rocked everything from bleached styles to the classic blues this year and styling them perfect each time. She is constantly one of the top voted for our weekly outfit posts and now you can vote for which of hers was your favorite from this year.
Please vote for your favorite Miranda outfit in the poll below. When we say favorite, we mean her whole head to toe outfit, not just the jeans she's wearing. If you hover your mouse over each gallery image, you can see the number assigned to cast your vote. You can also vote in the other celebrity polls here.


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