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The Mythological God Test
Eternally scavenging for food, he represents the most basic instincts, but in other narratives, he is also the father of the Indian people and a potent conductor of spiritual forces in the form of sacred dreams. In the Myth of the Stars and the Moon he is shown as a wise counsellor even.
There are more stories about him than stars in the sky. For example, did you hear the one about the Spying Moon? It seems that someone had pinched the moon, and Coyote offered to stand in as replacement. Everyone agreed that he made a fine moon, but from his elevated position Coyote could see everything that was going on. Being of an irritating disposition, he couldn't resist blowing the whistle on friends and enemies alike. "Hey, look what Badger is doing behind his tepee!"
Pretty soon everyone was sick of his snooping and voted him out of the sky. But nothing can keep Coyote down for long. Being an old show-off, he loves to impress the girls by juggling his eyeballs. One day he threw one so high it got stuck in the sky and became the star Arcturus. So even now he's keeping an eye on us all.
The Fifteen Gods
These are the 15 categories of this test. If you score above average in
all or none of the four variables: Dagda. Erudite: Thoth. Sensual: Frey. Martial: Mars. Saturnine: Mictlantecuhtli. Erudite & Sensual: Amun. Erudite & Martial: Odin. Erudite & Saturnine: Anubis. Sensual & Martial: Zeus. Sensual & Saturnine: Cernunnos. Martial & Saturnine: Loki. Erudite, Sensual & Martial: Lug. Erudite, Sensual & Saturnine: Coyote. Erudite, Martial & Saturnine: Hades. Sensual, Martial & Saturnine: Pan.
All possible test results
More properly known as The Dagda, he was the Earth Deity-Father of both Gods and men. In this respect he was the Celtic equivalent to Cronus or Zeus of the ancient ... Read more
All right, I'll be honest. The Aztec God of the Dead had an awfully long name, not quite as intimidating as the names of his equivalents, Hades (Greek mythology) or Pluto (... Read more
Julius Caesar should have listened to that old soothsayer who warned him to "beware the Ides of March." About the most hazardous time of the year during the reign of the Roman Empire was... Read more
Loki, a Trickster God similar to Coyote of the North American mythology, was vitally important among the Norse Gods. He was the most colourful and interesting of them all. ... Read more
Frey was, just like his twin sister Freya, a member of the Vanir family and thus a God of fertility and love. Along with Odin and Thor he was one of the most popular Nor... Read more
Cernunnos was one of the most important of all the Celtic Gods. He was the horned God of fertility, sexual love, the wilderness and wild animals. He was known as the stag deity and as su... Read more
This supreme God of Gods was worshipped throughout the Greek world, and his influence spread to every culture of antiquity. Idealized as the very model of the practical ruler, Zeus was n... Read more
Some people have extremely sensitive nerves and tend to become startled very easily. For this we can thank the God Pan who, according to the Greeks, was responsible for the irrational te... Read more
Thoth, the Egyptian God of secret wisdom, intellect, geometry and other forms of higher mathematics, was also the God of books and learning, of writing and numbers. And above all, he was... Read more
Anubis was the Egyptian God of funerary rituals and the protector of the dead as well as the judge of souls and ruler of the underworld. Since it was his duty to weigh souls (along with ... Read more
King of the Gods and leader of the Aesir family, Odin was all wise, all seeing, and almighty. He was the very personification of authority, skilled in battle, and swift in administering justice... Read more
Simply put, Hades was a God of the Underworld, comparable to Midir of the Celts. After dying, a person entered the Underworld by first travelling through the groves of Persepho... Read more
Amun was a mysterious God indeed. His very name basically means "what is hidden", "what is not seen", "what cannot be seen", and though even his form was said to be unknown, he was depicted... Read more
Coyote was an important being to several Native American tribes. He was one of those tricksters that are found in several world mythologies, in fact very close in temperament and deed to... Read more
The God Lug certainly cut an impressive image. Lug was a mighty hero, often portrayed as a blond muscle-man, all decked out in magnificent armour complete with helmet and shield of gold. A... Read more
More properly known as The Dagda, he was the Earth Deity-Father of both Gods and men. In this respect he was the Celtic equivalent to Cronus or Zeus of the ancient ... Read more
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Copper interconnects are fast approaching their limitations, and developers are looking for new ways to transmit information without the electromagnetic interference that goes hand in hand with copper wire. Because Light Peak uses lasers rather than electrical signals, there is less interference and more opportunity for long distance transmission."
Business software left the office and moved into the home long ago. If you've ever lost the password to Word, ZIP or PDF file in misguided attempt to protect data from prying eyes, this guide to Decrypting Document and File Passwords is a life saver. PCSTATS Tips

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iHerb Customer Reviews
Savings of: $9.43 (36% off)
Sorry, this product is no longer in stock.
Immediate symptomatic relief from hayfever symptoms
Posted by mygreathealth on Oct 18, 2010
Within minutes of taking this capsule acts like an antihistamine and dries out my nose, reduces itchiness and reduces sneezing. I am finding it a wonder during the hayfever season.
Posted by Reviewer2934515 on Oct 19, 2010
I have suffered headaches for years, At least one to two a week. Since taking this product on a regular basis, they have stopped so far. Great product highly recommend.
Reduces migraines
Posted by Reviewer1406241 on Jan 12, 2011
I do believe that I notice a decrease in the severity and frequency of migraines due to the use of Now Butterbur with Feverfew. I take two to three capsules a day. It is important to be consistent with taking it. I wish iHerb would keep more in stock since it seems to sell out frequently. iHerb offers excellent service, otherwise.
Good as Gold So Far
Posted by Reviewer3087837 on Feb 18, 2011
I'm a migraine sufferer in Honolulu, which is a land plagued by "vog" (super-serious volcanic pollution that comes over from the big island). Usually, when the vog rolls around to stay, I am flattened by migraines, but for the past two very voggy weeks, though I've still had super-nasty headaches and my sinuses and ears are clogged, none of my headaches have turned into migraines. This is the first time in my 2.5 years of living here that this has been the case. The only thing I have done differently is to take 2-3 of these butterbur things every day. Clearly, this is some sort of migraine-blocking miracle herb, and I'm glad I bought it! Here's hoping this continues to be the case.
Good allergy relief
Posted by Reviewer2524520 on Apr 12, 2011
I take this in combination with quercetin and nettle extracts for effective seasonal allergy relief.
Posted by Reviewer2063486 on Apr 18, 2011
Works very well for my most difficult headaches
Posted by Reviewer1147981 on Sep 19, 2011
This is an incredible purchase. My daughter has had unbelievable migraines for 20 years. She's been to the doctor, chiropractor, etc with little to no help other than an adjustment or prescription for migraine medication which does not help that much nor does it last until the next day. I don't even know how I came across this product, but thought I would give it a try. It's now been two weeks and she hasn't had ONE migraine. WOW....unbelievable. Thank you so much!!!
Now Foods Butterbur
Posted by Reviewer3196397 on Oct 17, 2011
Works very well for my wife's allergies. Will buy again.
Works for spasms
Posted by Reviewer1556539 on Nov 08, 2011
Taking if or bronchial and bladder spasms and noticed relief for both without having to take it daily.
Posted by Blessed1 on Nov 27, 2011
I got tired of taking ibuprofin for my sinus headaches and aches because of the chemicals in it Your body does not need chemicals and this stuff works great immidietly pain is gone and stuffiness is gone. My son takes it also and it works great I will never go back to putting chemicals in my body !!!!! I will definately keep buying this product .


text: GAP conditions This topic contains 5 replies, has 5 voices, and was last updated by atown 3 yrs. Viewing 6 posts - 1 through 6 (of 6 total) ← Forums Home Author Posts Author Posts look out Private Message Jul 12 2013 at 4:44pm # I was wondering if anyone knows what condition the GAP trail is to past Boston. With the hard rains, are there washed out areas? Was planning on doing an overnighter this weekend. thanks! Drewbacca Private Message Jul 12 2013 at 4:58pm # Not too bad, I was out there a week ago (during the rain, more or less). There are some puddles around OhioPyle but crews have been good about filling them up with rocks (a little rough for a 28mm tire but fine for a wider tire with lower pressure). We mostly encountered fallen trees but there were crews out with saws within hours. I'd worry less about a build up of damage over a week and more about immediate damage from a previous night's storm. Flyfishing3 Private Message Jul 16 2013 at 7:24am # i'm assuming they are back on, but 2 weeks ago the lights in the savage tunnel were out. pinky Private Message Jul 16 2013 at 8:30am # I went out this weekend on my road bike. It was pretty much fine other than one washout about 3 miles past Boston. It was passable on foot (but had lots of goopy mud). I was just out for the day so I turned around there. Drewbacca Private Message Jul 16 2013 at 9:39am # @flyfishing3, savage tunnel lights are back… https://www.facebook.com/GAPTrail atown Private Message Jul 16 2013 at 10:41am # (edit: nevermind, wrong thread…ignore) Viewing 6 posts - 1 through 6 (of 6 total) ← Forums Home You must be logged in to reply to this topic.


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Injured Marine Semper Fi Fund
Rating: 4.78 stars 36 36 reviews
825 College Blvd Ste 102, PMB 609 Oceanside CA 92057 USA
Marines and Sailors, along with members of the other service branches, who are attached to Marine units, are deployed all over the world protecting and preserving our freedom. As a result, many are injured in combat operations and in training accidents, or face life threatening illness. Injury to a service member causes an immediate crisis for his or her entire family; not just emotionally, but also financially. Depending on the type of injury, recovery can take many months, and rehabilitative care can take years, often in hospitals far from loved ones. Airplane tickets, food, lodging, car rental, phone bills and lost wages are some of the things that can create an unexpected financial hardship during what is already a very stressful time.
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Reviews for Injured Marine Semper Fi Fund
7 people found this review helpful
I've been working as a volunteer with the IMSFF here in the Pacific Hawaii, since 2004. It gives me great pleasure assisting the Marines, Sailors and their immediate love ones in crisis and in need of great assistance, this is a great program who has gone the distance above and beyond to assist the Corps, Navy and all those services that is in direct support of the Marine Corps/Navy Team.
More Feedback
I've personally experienced the results of this organization in...
Several Cases that i've processed and I've experience the rapid turn around services provided to the applicants
What I've enjoyed the most about my experience with this nonprofit is...
The appreciation, our applicant demonstrate upon assistance from the program, and the satisfaction,relief and or happiness displayed by the service member and his spouse as the out-come of the request.
The kinds of staff and volunteers that I met were...
Very honest, professional and at times were consistent with above and beyond action to assist the applicant.
If this organization had 10 million bucks, it could...
Provide further assistance to needed service members dependents and or their spouses.
How frequently have you been involved with the organization?
About every week
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More htaccess questions.
Here's the htaccess I'm using to protect my members area:
AuthUserFile /usr/local/apache/www/chriss/chezchris.ca/data/.htpasswd
AuthName MEMBERS
AuthType Basic
<Limit GET POST>
require valid-user
I want to be able to offer a "tiered" membership option allowing access to more withing my membership area for more money. So I need to protect directories separately. With the file listed above does anyone know if I can add some lines in??? I'd try it on my server but I don't want to mess with my present customers and accidently block them out. I'd basically be adding separate data locations for the password files to different directories. So does anyong know if I can do this --
AuthUserFile /usr/local/apache/www/chriss/chezchris.ca/data/.htpasswd
AuthUserFile /usr/local/apache/www/chriss/chezchris.ca/vdata/.htpasswd
AuthUserFile /usr/local/apache/www/chriss/chezchris.ca/data1/.htpasswd
AuthUserFile /usr/local/apache/www/chriss/chezchris.ca/data2/.htpasswd
AuthUserFile /usr/local/apache/www/chriss/chezchris.ca/data#/.htpasswd
AuthName MEMBERS
AuthType Basic
<Limit GET POST>
require valid-user
-- in other words repeat the "AuthUserFile" line???
I don't want to have to duplicate my members area into different directories. I want to be able to specify who gets in.


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The presidential campaign is front and center, but voters in both Vermont and New Hampshire will also pick new governors this year.
Strong Dollar Pulls The Rug Out From Under Some Secondhand Shops
Clothes that don't sell in thrift shops are often gathered up and offered for sale to consumers around the world. But as that market falls apart, secondhand shops are taking an unexpected financial hit.
Vermont Receives Federal Grant To Combat Prescription Opioid Abuse
Between 2010 and 2014, the deaths of 188 people in Vermont were tied to opioids prescribed by doctors.
Vt. Man Bequeaths Millions To Brattleboro Library And Hospital
A quiet local man invested for years and left his profits to Brooks Memorial Library and Brattleboro Memorial Hospital.
For New England, A Mix Of Old And New Bosses
Governors in the six New England states will be sworn in this week.
Study: Maple Syrup Production Declines After A Big Seed Year
This coming season should be a good one for maple syrup producers in New England. That's the word from Joshua Rapp, who co-authored a Tufts […]
Vermont Governor's Race Still Contentious
Vermont Democratic Governor Peter Shumlin's narrow defeat last week of Republican Scott Milne means the state legislature will have the final say on the matter in January. The Vermont constitution requires lawmakers take a special vote — a secret ballot — if neither candidate gets more than 50 percent in the election.
Plenty Of New England Governors Races Tuesday; Updates From Connecticut And Vermont
We check-in with reporters from Connecticut and Vermont for the latest on those state's gubernatorial elections.
Vt. Primaries Unlikely To Bring Any Big Surprises
The state holds its primaries on Tuesday, with the Republican nomination for governor up for grabs.
Want To Feed That Bear? Grab Your Checkbook.
Vermont officials for the first time used a new law allowing them to fine people who intentionally feed bears.
Mass., Vermont Among Leaders in Prisoner Health Care Spending
The study examined how much money states spent on prisoner health care during a four-year period.
Vernon Vt. Police Department To Close, Sheriff Assumes Policing Duties
The town voted earlier this year to shut its police department over concerns that the closing of the Vermont Yankee nuclear power plant will significantly cut its tax base.
New England Dairy Farms On The Decline, Despite Positive Signs For Regional Agriculture
The number of dairy farms in Massachusetts dropped significantly between 2007 and 2012, according to US Census data out this month.
Massachusetts Officials Urge Caution To Keep Pig Virus Out Of State
A deadly pig virus has hit 27 states throughout the country, including Vermont. In Massachusetts agriculture officials are urging swine farmers to take precautions.
Official: 'Jury Duty' Phone Scam Spreading In Vermont
State officials are warning residents to be on the lookout for callers threatening consumers over jury duty.


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Of heroes, descendants and miracles
Natalie Blackman, who plays Sarah Franks in the film, thought that given the extreme circumstances, it was a miracle that more handcart pioneers didn't die on the trail.
Emily Wadley, who plays the single mother (Elizabeth Panting) of two children, said she liked two miracles. The first miracle was when Louisa Mellor found a pie on the side of the trail and shared it with her distraught mother. Another miracle was when the Cunningham family thought their teenage daughter, Betsy, died during the frigid night. The family left Betsy on the side of the trail but returned hours later when her mother remembered the family had been promised in a blessing that every member would arrive in Zion.
"They called the Lord on his promise and it came to pass," Wadley said.
Kenzie Stinger, a 15-year-old from Kaysville, Utah, played the role of Betsy Cunningham. Her mother, Kim, and five brothers also had roles in the film. Kim is a descendant of Nathan Tanner Porter, who traveled part of the way with the Willie company, then helped rescue them. Being Betsy opened Kenzie's eyes to a new perspective. She described her experience as "inspiring" and "spiritual."
"I only had to endure a little of laying in the snow. They had to do much more than that. I am thankful for what they did and all the things they went through," Kenzie said. "It hit me that it's a true story, it actually happened, and the Lord can really perform miracles for us."
For more on "17 Miracles," visit 17miracles.com.
Email: email@example.com
Twitter: tbtoone
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text:
(Sept. 16, 2011)-- The old UTSA adage, "Come here, go far" came to life this summer for five COLFA students as they and associate professor William McCrary (Department of Music) spent the first two weeks of August participating in the Yunnan Opera Festival in Kunming, China.
Department of Music Vocal Performance majors Kristin Degroot, Laura Estrada, Christina Taylor, Darius Thomas, and Jacob Valadez each performed major roles in Puccini's Gianni Schicci and Act II of Mozart's Die Zauberflöte. Both operas were presented in their original language and, according to local authorities, were the first productions of western opera to be performed in Kunming.
The three evenings of performances were the culmination of two weeks of voice lessons, diction classes, master classes, music rehearsals, and staging rehearsals in what the Chinese city referred to as the City of Eternal Spring (due to Kunming's yearly temperate climate).
When asked about the educational experience Darius Thomas stated, "The invaluable education and musical experience I received from China will be with me always. The quality of the students and professors were the best in the nation."
The program included students and professors from the United States, Taiwan, and China.
Kristin Degroot noted, "It was astounding to experience, not only the beautiful differences in our two cultures, but also the large number of similarities." Christina Taylor added, "Performing with people from all over the United States, China, and Taiwan was amazing. It was incredible to see the singers grow so and amazing to watch the Chinese students, on stage and in the audience, experience Western opera for the first time. It was absolutely a 'once in a lifetime' experience."
Each performance was attended by local adults as well as a hundred or so school children from a local visual and performing arts school. After each performance, the singers were presented with gifts from the children as a thank you for the performance and as a way of sharing the Chinese culture with the American students. When asked their reaction to the performance, several children stated, "It was awesome!"
The trip was partially funded by UTSA donors Charles and Charlotte Walker as well as by efforts of each student. Jacob Valadez, who begins graduate study at Baylor University this fall commented, "We were so thankful that Charles and Charlotte (Walker) helped us with the airfare. Several of us would not have been able to go without their generosity. As for me, China was a fun and an exciting experience! Being immersed in someone else's culture and getting acquainted with their customs was such a shock. I learned that one must not take for granted the things we are lucky to have here in America."
The UTSA Interactive Technology Experience Center camps are for curious youth who are interested in STEM and related topics. This week, campers will study environmental science, robotics and computer science.
UTSA Main Campus
In four sessions of this weeklong day camp for 9 to 13-year-olds, campers will participate in indoor and outdoor activities while exploring ancient technologies from around the world and the new technologies archaeologists are using to discover them.
UTSA Center for Archaeological Research, Main Campus
The exhibit "Girl's Eye View" was produced by students who documented life on San Antonio's East Side with photography, poetry and film.
UTSA Institute of Texan Cultures
This fast pace program is designed for students who took the math placement exam and scored just under the acceptable score for entrance into MAT 1093 or 1214.
UTSA Main Campus
Skilled youth players will get an intense camp experience with Roadrunners baseball coaches. Camp will be limited access, more individualized instruction, in-depth teaching in skills areas and lectures and drill work in the areas of team defense and offense.
UTSA Main Campus, Roadrunner Field
Experience a very different summer camp! The UTSA East Asia Institute is teaching kids Japanese through language, culture, art, crafts, music, cooking and more. For kids age 6-12. For more details, email firstname.lastname@example.com.
Main Building (MB 1.126), Main Campus
7 to 12 year-olds will explore Mayan Culture in a three-day sessions, concluding at the Witte museum, where campers will have the chance to see the new "Maya: Hidden Worlds Revealed" exhibit.
UTSA Center for Archaeological Research, Main Campus
Other Calendars
» UTSA Events | » Academic | » Institute of Texan Cultures
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.


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"Yes, our regulatory agencies are incompetent. But they are incompetent by design." --writer David Goldstein
HTS costs up to $300 a month to operate. We need your help!
I just join, besides that Basic Missions Basic Level 6 is not working. I am very familiar with ASCII (American Standard Code for Information Interchange) and in that level you have a code that reads Ob35958= and it's Oa125/15 when it's a decryption. When I enter it, it say error. Will you please check it or tell me if I did something wrong.


text:
Northwestern Mutual is honoring Stephen R. Voboril, a New Berlin-based financial representative, with membership into its 2012 Forum group, which recognizes an outstanding year of helping people achieve financial security. Only the top five percent of Northwestern Mutual's more than 6,000 financial representatives receive this annual honor.
Voboril, affiliated with the Holter Network Office in New Berlin, WI, joins this distinguished group along with representatives from across the country who have qualified for this honor.
"People are turning to trusted financial representatives like Stephen to help them plan for the long-term," said Todd M. Schoon, executive vice president at Northwestern Mutual.
Forum honorees were recognized at a conference held Nov. 11-14, in Scottsdale, Ariz. Honorees also learned new insights from prominent speakers and shared knowledge with colleagues during the conference.
About Northwestern Mutual
The Northwestern Mutual Life Insurance Company – Milwaukee, WI (Northwestern Mutual) – among the "World's Most Admired" life insurance companies in 2012 according to FORTUNE® magazine – has helped clients achieve financial security for more than 155 years. As a mutual company with $1.2 trillion of life insurance protection in force, Northwestern Mutual has no shareholders. The company focuses solely and directly on its clients and seeks to deliver consistent and dependable value to them over time. Northwestern Mutual and its subsidiaries offer a holistic approach to financial security solutions including: life insurance, long-term care insurance, disability insurance, annuities, investment products, and advisory products and services. Subsidiaries include Northwestern Mutual Investment Services, LLC, broker-dealer, registered investment adviser, member FINRA and SIPC; the Northwestern Mutual Wealth Management Company, limited purpose federal savings bank; and Northwestern Long Term Care Insurance Company; and Russell Investments.
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Viewing comments for katman« back to profile
5 of the best tries from week 3 of RWC 2015
The deranged screaming towards the end of the Scotland try deserves a special mention.
9 Months, 2 Weeks ago
South Africa crush USA as Habana equals Lomu's RWC tries record
Yes, that was more than a little confusing. Even my wife, who knows little about the rules, asked me why play went on with an advantage if a penalty try was coming.
Almost as confusing as the next game - Namibia vs Georgia - where the Georgians were totally dominant in the scrum, only two have two Namibian props carded right on their own line leading to uncontested scrums.
9 Months, 2 Weeks ago
Georgia edge Namibia to go third in pool and all but qualify for 2019 RWC
Strangest game of rugby. Georgia were totally dominant in the scrums, the tackles, the backline play... basically everywhere but the scoreboard. Credit to Namibia for hanging in there, but if it weren't for some real clangers by the Georgians with the tryline begging (and a few fortuitous calls by the ref), the score could have been much bigger.
9 Months, 2 Weeks ago
South Africa crush USA as Habana equals Lomu's RWC tries record
That's better. I bit of everything in this win - slick backline play, mauls, strong scrumming, opportunism. Not always pretty, but very effective. I reckon it will be SA vs Wales in the QF. That should be a cracker of a game.
9 Months, 2 Weeks ago
Alesana Tuilagi banned for 5 weeks for 'kneeing' Japanese tackler
Pretty soon running will be outlawed. Players will be required to walk briskly, like that idiotic athletics sport of racewalking. In fact, I'm going to suggest that someone do a send-up of this and film a rugby game where players racewalk and tackle politely.
9 Months, 2 Weeks ago
One week ban for Michael Hooper as he pleads guilty to Foul Play charge
So "entry point of two weeks" means nothing if you can cite a bunch of reasons to make it one week only?
Surely "entry point of two weeks" means, if he's been an angel in all other respects, then he gets the minimum of TWO WEEKS. If not, it slides up the scale.
9 Months, 3 Weeks ago
Michael Hooper cited for this dangerous cleanout on Mike Brown
If Hooper gets banned, who will replace him? Do they bring Ben McCalman on at 8 and move Pocock to 7? Or Palu perhaps? Either way, they don't lose an awful lot. What they sacrifice in Hooper's ball poaching they make up in a big, hefty ball carrier.
9 Months, 3 Weeks ago
Michael Hooper cited for this dangerous cleanout on Mike Brown
To be honest, Robshaw's complaining to the referee is just plain ineffectual. Whenever you see him, he's having some gesticulating moan at the ref, and then he always walks away sulking. If he did that less often and saved it for the incidents when he really has a leg to stand on, he would have a far better success rate.
I was watching Sergio Parisse in the Ireland game and the way he deals with the ref, and it's chalk and cheese. He never loses it or sulks. He immediately accepts when a situation is unsalvageable, and then he drags his insolent team mates away from the ref before they make him angry. I think a lot of captains can learn from his example.
On this clean-out - I think it's a clear case of dangerous play and Hooper will likely get a couple of games off. Harsh, perhaps. But fair.
9 Months, 3 Weeks ago
England knocked out of home World Cup by outstanding Wallabies
Which is clearly not a very good way to do it. Ask twitter to choose between Foley, Pocock and Launcbury while the whole of Australia is asleep. Okey dokey then.
9 Months, 3 Weeks ago
New Japanese Super Rugby team confirmed as being called The Sunwolves
Welcome Sunwolves. Pity you're going to lose your first game. But don't lose heart.
9 Months, 3 Weeks ago


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Hand-carved elephant ivory made in Hong Kong in the 60's (well before the ban in '89, therefore it is 'legal' to sell). The board is 10" folding type with ivory inlay between squares (?). King measures 2". Dark pieces are tea-stained to provide coloration. The set itself is in fantastic condition - display piece and even still has the tags on it!! Email me if you are interested to lean more. Thanks.
Beautiful set. Did they actually stain the ivory?
I have something similar -- pieces only, no board -- but only the bottoms are marked/painted black.
Have you had any offers on this? I'm wondering what it might be worth, re: insurance.
What is the price Rick lowman
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Can a Paladin have more than one Smite working at the same time against different foes?
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It's not stated that they can't in the core rules, so I would say that you can if your level is high enough to warrant multiple uses of Smite per day.
In my opinion it kind of goes against the intent of Smiting, but there seems to be no rules reason why you can't. Much the same way you can smite a target and then switch to attack another target to get an AC boost. If Paizo didn't want players to be able to do this they would have specified.


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RopeDirector: Alfred Hitchcock
Cast: Alfred Hitchcock, James Stewart, John Dall, Farley Granger
View All Available Formats & Editions
Rope, Alfred Hitchcock's first color film, was adapted from Patrick Hamilton's stage play Rope's End by no less than Hume Cronyn. Loosely inspired by the Leopold-Loeb case, the plot concerns two implicitly homosexual college chums, played by Farley Granger and John Dall. Their heads filled with Nietzschean philosophy by their kindly professor James Stewart, Granger and Dall kill a third friend just for the thrill of it. The boys hide the body in an antique chest in the middle of their posh apartment, then perversely arrange to hold a dinner party around the chest, inviting the victim's family, friends and fiancee (Joan Chandler), as well as their intellectual role-model Stewart. As the guests wander obliviously around the sealed chest, the killers make snippy, veiled comments about their deed--never going so far as to reveal the existence of the body nor their involvement in the murder. As all the guests file out, however, professor Stewart begins to suspect that something is amiss. In Rope, Hitchcock attempted the daunting technical challenge of filming the entire picture in one long, seemingly uninterrupted take. Actually, there are several edits in the movie: since a reel of film was divided into two ten-minute minireels back in 1948, the internal reel-breaks are "fudged" by having a dark object briefly obscure the camera lens, sustaining the illusion that no editing has taken place.
Editorial Reviews
Product Details
- Release Date:
- 08/03/1999
- 0096898480932
- Original Release:
- 1948
- Rating:
- Source:
- Universal Studios
Cast & Crew
|James Stewart
|Rupert Cadell
|John Dall
|Brandon Shaw
|Farley Granger
|Phillip Morgan
|Cedric Hardwicke
|Mr. Kentley
|Constance Collier
|Mrs. Atwater
|Joan Chandler
|Janet Walker
|Douglas Dick
|Kenneth Lawrence
|Edith Evanson
|Mrs. Wilson the Governess
|Dick Hogan
|David Kentley
Technical Credits
|Alfred Hitchcock
|Costumes/Costume Designer
|Dinsmore Alter
|Special Effects
|Ben Hecht
|Sidney Bernstein
|Howard Bristol
|Set Decoration/Design
|David Buttolph
|Score Composer
|Hume Cronyn
|Lowell J. Farrell
|Asst. Director
|Perry Ferguson
|Art Director
|Leo F. Forbstein
|Score Composer,Musical Direction/Supervision
|Emile Kuri
|Set Decoration/Design
|Arthur Laurents
|William Skall
|Joseph A. Valentine
|Perc Westmore
|William H. Ziegler
Customer Reviews
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I love Alfred Hitchcock and Jimmy Stewart solo and better together, but their first collaboration could have been better. Jimmy Stewart holds the picture together with his top notch performance as the curious boarding school head master to John Dall and Farley Granger. The storyline is a little grotesque, but enjoyable with Hitch's first crack at color films, and long, uncut takes in the scenes using thousands of feet of film at once. Good!
Great, but a bit grotesque especially when Brandon tied up some books for David's dad with the same rope that he had used to kill David with, and then stuffing the body under a coffin that they serve a dinner on (inviting all of David's friends and parents) but overall it was great cast. I kept thinking, 'when will he find out?' all during it.
This film was fantastic! I had seen it when I was much younger and remembered it being good, but having just re-watched it I was struck by how much it felt like a filmed play. The very long shots helped establish the real-time aspect of this thrilling story and Hitchcock's brilliant directing really shines. Great performances all around and with any Hitchcock picture, every moment feels like it was carefully thought out and executed for the greatest effect. Watching Jimmy Stewart (Rupert) piece together the evidence was as exciting as watching John Dall (Brandon) and Farley Granger (Phillip) try to keep it together. I've read that Hitchcock wasn't particularly fond of this film, and I'll grant that he certainly has created better films, but I'd take an evening of Rope over an evening of Final Destination 3 any day.
When two wealthy and bored young men decide to do away with an old prep-school friend, that's bad enough. These two are perverse enough to decide to have a party with his body lying in the trunk they are serving food from. And if that's not enough, the guest list includes the girlfriend, their friend's parents, the girlfriend's ex-boyfriend and the housemaster from their prepschool (James Stewart). Hithcock does an amazing job, once again, of having this whole film take place from this one apartment. You see the two young men start fighting each other as the evening wears on and people start asking questions. It is a night fraught with tension right up to the end.


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Major depressive disorder is a leading debilitating disease known to occur at a two-fold higher rate in women than in men. The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking.
Using the chronic unpredictable stress paradigm (CUS), we investigated whether male and female mice with inducible BDNF deletion in the forebrain were more susceptible to depression-related behavior.
We demonstrate that in certain behavioral measures the loss of BDNF lowers the threshold for females studied at random throughout estrus to display anxiogenic and anhedonic behaviors after chronic stress compared to wild type females. However, the loss of BDNF in forebrain does not increase the susceptibility to depression-like behavior in males.
These gender differences suggest a role for BDNF in mediating some aspects of depression-related behavior in females.
Major depressive disorder (MDD) is a leading debilitating disease in the U.S. and affects about 14.8 million Americans over 18 each year. The clinical presentation of MDD has a spectrum of symptoms including anxiety, anhedonia, loss of appetite, and sleep disturbances as set forth in the Diagnostic and Statistical Manual (1). Notably, MDD occurs twice as often in women than in men though the cause is currently unknown (2, 3).
Recent work suggests an important role for neurotrophins in psychiatric diseases including MDD (4, 5). Brain-derived neurotrophic factor (BDNF), the most prevalent growth factor in the brain, may underlie depression-related behavior and mediate the therapeutic action of antidepressants. The neurotrophic hypothesis of depression suggests that loss of BDNF from hippocampus contributes to neuroanatomical and functional alterations that underlie aspects of depression-related behavior, while antidepressants may mediate therapeutic effects in part by increasing levels of BDNF in this brain region (6). Recent studies demonstrate that BDNF heterozygous mice, and mice with inducible BDNF deletion in forebrain (inducible knockouts), and conditional BDNF knockouts, display attenuated responses to antidepressants in forced swim test (7–9), a paradigm that predicts antidepressant efficacy and by analogy 'depression-related' behavior (10, 11). Indeed, we have recently extended these findings to show that BDNF in dentate gyrus of hippocampus is required for antidepressant efficacy in this paradigm (12).
While these studies demonstrated that loss of BDNF produces alterations in antidepressant responses, BDNF heterozygous mice, inducible BDNF knockouts (KOs), and dentate gyrus specific BDNF KOs were indistinguishable from wild type littermate control mice in 'baseline' depression-related behavior; this suggests that loss of BDNF per se is not sufficient to mediate 'depression-like' behavior (8, 12, 13). However, it is possible that loss of BDNF may increase vulnerability to particular chronic perturbations.
To investigate this possibility, we exposed BDNF inducible KOs to a chronic unpredictable stress (CUS) paradigm that is known to induce alterations in depression-related behaviors in rodents. We examined BDNF inducible KOs, since this line has a regionally restricted forebrain specific deletion of BDNF compared to our conditional line, to gain a direct assessment of the neurotrophic hypothesis of depression. Since previous work demonstrated that loss of BDNF produces gender specific effects, we examined both male and female inducible KO mice in depression-related behavior following CUS.
The inducible BDNF knockout mice were generated from a trigenic cross of NSE-tTA, TetOp-Cre, and floxed BDNF mice as previously described (8). For all behavior testing, male and female mice were age (three to six months) and weight matched and groups were balanced by genotype. Eight experimental groups of 7–14 animals were tested; male and female BDNF knockouts (KOs) or wild type littermates (CTLs), nonstressed or stressed (Supplement 1 - Table S1). The order of behavior tests was performed from least to most stressful and blind to group and genotype (Supplement 2 -Figure S1A). For more information, refer to supplemental methods (Supplement 3 –Materials and Methods).
Our CUS model was adapted from Muscat et al. (14) and Monleon et al. (15). Mice were exposed to one or two stressors for a period of 4–12 hours during each 24 hour period over 52 days, though animals were not stressed within eight hours of behavioral testing. Stressors consisted of food or water deprivation, periods of overnight illumination, 45° cage tilt, single housing, and bedding soiled with water or rat feces (Table 1).
Mice were placed in cages and locomotor activity was recorded for 2 hours under red light by photocell beams linked to computer acquisition software (San Diego Instruments, San Diego, CA).
Mice were assessed for activity in a 72×72 cm open field (OF) arena at 40 lux for 5 minutes. Movement was tracked by video (Ethovision3.0 Noldus, Leesburg, Virginia) for time spent in center (14×14 cm) and peripheral zones (5 cm around perimeter).
Mouse fur state was rated on a 4-point scale with another point each for either hunched posture or redness around eyes (6 points total). The fur scoring scale (Supplement 3 – Materials and Methods) was adapted from Mineur et al. (16).
Sucrose consumption test (SCT) protocol was adapted from Gourley et al. (17). Mice were habituated to 1% sucrose solution and water deprivation periods followed by 1 hour of sucrose access. On test day, mice accessed sucrose solution for 1 hour and the following day accessed water. We measured percent sucrose intake compared to total volume consumed in both trials. For more information, refer to Supplement 3 – Materials and Methods.
The novelty suppressed feeding (NSF) task was performed as previously described (18). Detailed methods listed in Supplement 3.
The tail suspension test (TST) was performed as previously described (19) and detailed methods are listed in Supplement 3.
The forced swim test (FST) was performed as previously described (10) and detailed methods are available in supplemental methods (Supplement 3 – Materials and Methods).
Blood serum was isolated from trunk blood samples by centrifugation. A high sensitivity corticosterone (CORT) enzyme immunoassay (EIA) was performed according to manufacturer's instruction (Immunodiagnostic Systems Ltd., Fountain Hills, AZ).
Fresh frozen whole hippocampi were dissected and total RNA was extracted using Trizol reagent (Invitrogen) according to manufacturer's instruction. Conditions for cDNA synthesis, amplification, and primer sequences were described previously (20). Fold change in BDNF expression is normalized to GAPDH.
Weight and locomotor data were analyzed with repeated measures ANOVA using SAS software to determine statistical significance (p<0.05). The fur score data were analyzed by logistical regression analysis followed with a Mantel-Haenszel test for frequency comparison between groups. Anxiety data, SCT, NSF, FST, TST, CORT, and BDNF expression data were analyzed by a 2-way ANOVA followed with multiple comparisons using a Bonferroni t-test to assess the difference among groups. Data are presented as mean ± SEM.
Mouse weights were monitored at an early, mid, and late time point during the time period of CUS (days 5, 21 and 40)(Supplement 2 - Figure S1B). In females, there was a significant stress effect (p<0.0001, F1,11=36.42), while there was no significant knockout effect (p=0.2722,F1,11=1.34) or interaction effect (p=0.2075,F1,10=1.82). For males, there was a significant stress effect (p=0.0135, F1,8=9.96), while there was no significant knockout effect (p=0.3016, F1,7=1.24) or interaction effect (p=0.3256,F1,7=1.12). Inducible BDNF KO mice have normal weight compared to littermate CTLs, similar to data previously reported (9). Our CUS paradigm was found to significantly impact weight of the animals over the course of the experiment. However, loss of BDNF in either sex did not further contribute to a change in weight following CUS.
Previous studies showed that a reduction in locomotor activity after CUS correlates to depression-like behaviors (21). Examining two hour locomotor activity in females following CUS revealed a significant stress effect (p=0.0335,F1,42=4.83) and knockout effect (p=0.0461,F1,42=4.22) while there was no significant interaction effect (p=0.1104,F1,42=2.66). Multiple comparisons using a Bonferroni t-test indicated that stressed KOs were significantly hypoactive compared to the other groups (*p<0.05)(insert, Figure 1A). To gain a better understanding of this difference in females, data were analyzed in 5-minute epochs (Figure 1A); there was a significant main effect of stress (p<0.0001, F1,11 =62.00) and a significant main effect of genotype (p<0.0001, F1,9 =57.91) and the number of beam breaks significantly decreased over time (p<0.0001, F23,299 =52.56) with a significant interaction between stress and genotype (p<0.0001, F1,9 =50.76) while there were no other significant interaction effects (* p<0.05). Total locomotor activity in males during a two hour period following CUS revealed a significant stress effect (p=0.0092,F1,30=7.75), with no significant knockout effect (p=0.1796,F1,30=1.89) or interaction effect (p=0.9385,F1,30=0.01). Multiple comparisons using a Bonferroni t-test indicated that under nonstressed conditions BDNF KOs are significantly hyperactive compared with wild type mice and that following stress CTLs show a significant decrease in locomotor activity compared to nonstressed CTLs (*p<0.05)(insert, Figure 1B). For males, locomotor data were analyzed in 5-minute epochs (Figure 1B); there was a significant main effect of stress (p<0.0001,F1,8 =86.32), a significant main effect of genotype (p=0.0046,F1,7=16.73), and the number of beam breaks significantly decreased over time (p<0.0001,F23,208 =50.57) while there was no significant interaction effect (*p<0. 05).
To determine the effect of CUS on anxiety-like measures, we assessed open field behavior. In this paradigm a decrease in duration of time in the center or a decrease in the number of entries to center is suggestive of an increase in anxiety related behavior (22). For females, examining duration in the center of the open field revealed a significant stress effect (p=0.0499,F1,45=4.06) while there is no significant knockout effect (p=0.5305,F1,45=0.40) or interaction effect (p=0.1829,F1,45=1.83). Multiple comparisons using a Bonferroni t-test indicated that stressed KOs spend significantly less time in the center compared to nonstressed KOs suggestive of an increase in anxiety (* p<0.05)(Figure 3A). In females, we examined the number of entries to the center and found a significant stress effect (p=0.0155,F1,45=6.33) while there was no significant knockout effect (p=0.3545,F1,45=0.88) or interaction effect (p=0.3239,F1,45=0.99). Multiple comparisons using a Bonferroni t-test indicated that stressed KOs have a significant decrease in the number of entries in the center of the open field compared to nonstressed KOs (*p<0. 05)(Figure 2C). We examined total distance traveled and during this test, like the initial five minute data point for locomotor activity, we did not observe any significant effect of stress (p=0.0854,F1,44=3.10), knockout (p=0.4798,F1,44=0.51) or interaction (p=0.8529,F1,44=0.03) for female mice and no significant difference among groups (p>0.05)(Supplement 4 - Figure S2A).
Measures of duration in the center of the open field for males revealed no significant stress effect (p=0.7146,F1,31=0.14), knockout effect (p=0.0884,F1,31=3.09) or interaction effect (p=0.3666,F1,31=0.84)(Figure 2B). In males, we examined the number of entries in the center and found no significant stress effect (p=0.4262,F1,31=0.65), knockout effect (p=0.0873,F1,31=3.12) or interaction effect (p=0.6111,F1,31=0.26)(Figure 2D). For total distance traveled, we did not observe any significant effect of stress (p=0.8213,F1,29=0.05), knockout (p=0.8842,F1,29=0.02) or interaction (p=0.5427,F1,29=0.5427) for male mice and no significant difference among groups (*p>0.05)(Supplement 4 - Figure S2B).
To address the impact of CUS on depression-like measures, we examined fur state, sucrose intake, and feeding in a novel environment. In examining fur state we were interested whether CUS resulted in more of an 'unkept' appearance, as observed by an increase in fur score as a measure of depression-like behavior. There was no significant main stress and main genotype effect and interaction effect from Logistic regression analysis (*p>0.05). However, in females we noted significantly poorer fur state in stressed BDNF KO mice as assessed by a higher fur score with respect to the other groups of animals (*p<0.05)(Figure 3A). In contrast, in males we generally noted a poorer fur state than in females, however there was no significant difference between groups (p>0.05)(Figure 3B). SCT is a paradigm used to measure an animal's responsiveness to a natural reward (23). A loss of sensitivity to reward has been suggested as a measure of anhedonia, an important feature of major depression. In females, there was a significant genotype × stress interaction effect (p=0.0278,F1,45=5.17). Multiple comparisons using a Bonferroni t-test indicated that stressed KOs had a significant decrease in percent sucrose intake compared to nonstressed KOs or stressed CTLs (*p<0.05)(Figure 3C). Importantly, there was no significant stress effect (p=0.0546,F1,45=3.89), knockout effect (p=0.7688,F1,45=0.09) or interaction effect (p=0.8213,F1,45=0.05) on water intake (*p>0.05)(Supplement 5 - Figure S3A). For males, there was a significant stress effect (p=0.0199,F1,31=6.02), while there was no effect of knockout (p=0.8997,F1,31=0.02) nor an interaction effect (p=0.5528,F1,31=0.36). Multiple comparisons using a Bonferroni t-test indicated no significant differences between groups (*p>0.05)(Figure 3D). The amount of water consumed was not significantly affected by stress (p=0.3893,F1,31=0.76), knockout (p=0.6705,F1,31=0.18) or interaction (p=0.9741,F1,31=0.00)(*p>0. 05)(Supplement 5 - Figure S3B). In NSF testing, an increase in the latency to feed suggests an increase in anxiety (18). In females, there was a significant stress effect (p=0.0049,F1,43=8.79) while there was no significant knockout effect (p=0.6509,F1,43=0.21) or interaction effect (p=0.5913,F1,43=0.29). Multiple comparisons using a Bonferroni t-test indicated that stress significantly increased the latency to feed in the CTLs (*p<0.05), with a similar trend observed in KOs (Figure 3E). For males, there was a significant knockout effect (p=0.0052,F1,29=9.16), while there was no effect of stress (p= .0532,F1,29=4.06) nor an interaction effect (p=0.1754,F1,29=1.93). Multiple comparisons using a Bonferroni t-test indicated that stress significantly increased latency to feed in CTLs compared to nonstressed CTLs and stressed KOs (*p<0.05)(Figure 3F).
We performed FST and TST, paradigms that are commonly referred to as depression-like tests and which have been shown to increase immobility in mice after CUS in other studies (24). An increase in immobility time is suggestive of an increase in depression-like behavior. For females in FST, there was no significant stress effect (p=0.9963,F1,45=0.00), knockout effect (p=0.4718,F1,45=0.53) or interaction effect (p=0.0931,F1,45=2.94)(Supplement 6 - Figure S4A). For males in FST, there was no significant stress effect (p=0.5919,F1,29=0.29), knockout effect (p=0.2265,F1,29=1.53) or interaction effect (p=0.9603,F1,29=0.00)(*p>0.05)(Supplement 6 - Figure S4B). Examining females in TST, there was no significant stress effect (p=0.7447,F1,31=0.11), knockout effect (p=0.6301,F1,31=0.24) or interaction effect (p=0.8980, F1,31=0.02)(*p>0.05)(Supplement 6 - Figure S4C). Males tested in TST displayed no significant stress effect (p=0.2959,F1,30=1.13), knockout effect (p=0.4904,F1,30=0.49) or interaction effect (p=0.2051,F1,30=1.68)(*p>0.05)(Supplement 6 - Figure S4D).
To assess the effect of stress on CORT levels in CTL and BDNF KO mice, we collected trunk blood 10–15 minutes after FST, an acute swim stress. We analyzed sera from these samples for CORT concentration by EIA. For female CORT concentrations, there is a significant genotype × stress interaction effect (p=0.0013,F1,42=11.92). Multiple comparisons using a Bonferroni t-test indicated that nonstressed KOs had a significant decrease in CORT levels compared to nonstressed CTLs and that stress significantly increases CORT levels in BDNF KOs compared to either nonstressed KOs or stressed CTLs (*p<0.05)(Figure 4A). For male CORT concentration, there is a significant knockout effect (p=0.0001, F1,24=20.25) while there is no significant stress effect (p=0.2152, F1,24=1.62) or interaction effect (p=0.3988,F1,24=0.74). Multiple comparisons using a Bonferroni t-test indicated that nonstressed KOs had a significant decrease in CORT levels compared to nonstressed CTLs and that stressed KOs had a significant decrease in CORT levels compared to stressed CTLs (*p<0.05)(Figure 4B).
We quantified expression of BDNF in hippocampus, a region of interest in stress-response and a well-characterized site of BDNF knockdown in this mouse line (9), to determine the gender-specific impact of stress on BDNF mRNA levels. We collected whole hippocampi from all mice subjected to behavioral testing and used quantitative PCR to analyze BDNF mRNA levels. For female BDNF levels, there is a significant knockout effect (p=0.0040,F1,34=9.51) and stress effect (p=0.0185,F1,34=6.12) while there is no significant interaction effect (p=0.4947,F1,34=0.48). Multiple comparisons using a Bonferroni t-test indicated that nonstressed CTLs are significantly different from the other three groups (*p<0.05)(Figure 4C). For male BDNF levels, there is a significant knockout genotype interaction effect (p=0.0040,F1,25=10.04). Multiple comparisons using a Bonferroni t-test indicated that, similarly to females, nonstressed CTLs are significantly different from all other groups (*p<0.05)(Figure 4D).
Results of this study demonstrate that in several behavioral paradigms female mice are more vulnerable to CUS than males. We found that loss of BDNF makes female mice more sensitive to some measures of anxiety and particular features of depression-like behaviors following CUS compared to littermate CTLs. In contrast, loss of BDNF in males fails to increase most measures of anxiety, anhedonia and depression-like behavior following CUS compared to wild type CTLs. This is not to say that there were no genotype effects observed following CUS in males, but rather that the effects of stress and genotype were more extensive in females than males. Collectively, these data suggest that loss of BDNF does not result in greater susceptibility to depression-related behavior per se, but rather is linked to expression of these behaviors in a gender-specific manner in response to stress. CUS paradigms have produced alterations in locomotor activity, anxiety-like behavior, fur state, sucrose consumption, forced swim test, tail suspension tests, and corticosterone levels in rodents (25, 26). However, most robust CUS effects on these measures are in rats and effects in mice have been more difficult to ascertain suggesting that mice may be more resilient to chronic stress (25). Most CUS studies have relied solely on males and our data would largely support the resiliency of male mice to stress in many of these behavioral paradigms. However, our data with female mice suggests they may have an increased vulnerability in some behavioral measures following CUS.
In females, we found that stress produced a significant decrease in total locomotor activity of inducible KOs compared to nonstressed CTLs, nonstressed KOs, and stressed CTLs suggesting that loss of BDNF in females exacerbated locomotor deficits. In males, we found that nonstressed inducible KOs were significantly hyperactive compared to nonstressed CTLs in agreement with previous findings (9). Following CUS, male CTLs displayed significant hypoactivity compared to nonstressed CTLs while a similar trend, although not significant, was observed in BDNF KOs.
We assessed anxiety-related behavior using the OF test. In females, we found that CUS in BDNF KOs significantly reduced the time in the center of the arena and the number of entries to the center, indicative of an increase in anxiety-like behavior, compared to nonstressed KOs. In males, loss of BDNF did not alter anxiety related behavior following CUS. Our data is in contrast to previous findings of anxiolytic like effects of CUS in elevated plus maze (27), however other reports utilizing chronic variable stress report anxiogenic like effects in this test (28) and further studies suggest that these differences may be accounted for by the length of time between stress exposure and testing (29).
We examined the effects of CUS in inducible KOs in paradigms that provide measures of depression-like behavior. We examined the fur state of animals to assess grooming behavior, SCT as a measure of anhedonia, and latency to feed in the NSF test in CTL and BDNF KO animals following CUS. In females, we found that in nonstressed conditions loss of BDNF did not alter fur score, sucrose intake or latency to feed in the NSF test compared to CTLs. Following CUS, we found that female BDNF KOs had a significantly poorer fur score and were more anhedonic than nonstressed KOs or stressed CTLs and displaying a strong trend towards an increase in latency to feed compared to nonstressed KOs. In male KOs, CUS did not produce significant differences in fur score or sucrose consumption compared to other groups, and in the NSF test BDNF KOs appeared less anxious following CUS than CTLs. Collectively, this data suggests that loss of BDNF in CUS females may increase anxiety related behavior and some measures of depression related behavior, however these effects are gender specific since similar effects were not observed in males.
We examined mice in the FST and TST, tests that are commonly used to assess antidepressant efficacy and, by extension, depression (30). Surprisingly, we did not observe increased depression-like behavior as assessed by increased immobility in either FST or TST following CUS in either females or males independent of genotype. The FST and TST are often associated with depressive phenotypes in rodents following acute stress (24). Our lack of a change in immobility in these paradigms may be due to the adaptive aspect of stress responses to CUS over time (31). Recent interest has focused on uncovering the genetic mechanism behind the consistent observation that some animals display resilience to stress (32, 33). To this end, neither susceptible nor resilient mice display differences in the FST or TST after chronic social defeat stress (33), although this finding is not unequivocal(34). It is possible that the lack of a change in depression-like behavior as determined here could be due to the fact these tests are designed to predict antidepressant efficacy rather than as measures indicative of depression-like behavior (10, 35).
As a physiological measure of stress to support our behavioral findings, we assessed CORT concentration. Rather surprisingly, we found that under nonstressed conditions loss of BDNF is associated with decreased CORT levels in both males and females. Furthermore, we found that susceptibility for developing depression-related behaviors in female BDNF KO mice after CUS was correlated to a significant increase in CORT levels compared to nonstressed KOs and stressed CTLs. In contrast, in males we found that CUS did not significantly alter CORT levels compared to baseline levels of CORT in nonstressed CTLs and KOs. These findings suggest that under nonstressed conditions there is an interaction between BDNF and CORT in that loss of BDNF significantly reduced plasma CORT levels although this was not significantly correlated with decreased anxiety or depression like behavior. Following CUS, we found gender specific effects of the interaction between BDNF and CORT. Interestingly, a significant increase in CORT levels following CUS was observed in female BDNF KOs, the animals with the most pronounced anxiety and in some measures depression like behavior here.
We examined BDNF mRNA expression in all female and male groups. We found that under nonstressed conditions, both female and male KOs had a significant reduction in BDNF in hippocampus in agreement with previous data (9). Following CUS, we found that both male and female CTLs showed a significant reduction in the amount of BDNF in hippocampus. Rather surprisingly, CUS did not further reduce BDNF levels in KOs compared to nonstressed conditions. This data suggests that there is a floor effect in the amount of BDNF reduction in hippocampus. Thus while there were significant behavioral differences in KOs following CUS, this was not directly correlated with the amount of BDNF mRNA.
Interestingly, studies examining the effect of gender on stress responses have shown that BDNF levels in dentate gyrus are reduced in females but not males after restraint stress in rats (36), contrary to what we observed. Instead, our data suggests that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis stress response between males and females may account for the gender differences in agreement with previous literature (37, 38). Recent studies have suggested that depression based gender differences may be the result of alterations in hormonal levels (39–41) or in neuroanatomical differences between males and females (42). It is for this reason that many laboratories utilizing female mice control for estrus cycle. However, in this study, we did not control for the estrous stage of females. While there may be concern that female mice cycling at different stages could impact the behavioral data and result in inconclusive data, we were able to observe significant behavioral effects even in spite of this concern. Our very large number of females in each group, which likely represents a sampling across all stages of cycling, may well have contributed to our ability to observe significant behavioral effects.
Intriguingly, a recent study has shown that in conditional BDNF KO mice there is evidence of increased depression-like behavior in females BDNF KOs but not males (9), however it is difficult to make direct correlations with the data presented here and the previous study as the pattern of BDNF deletion in these various BDNF lines is quite different suggesting that regional pattern of BDNF deletion may influence depression based behavior. Future studies will be necessary to examine the mechanistic link between BDNF, gender differences, and the regional effect of BDNF in susceptibility to depression-related behavior.
Our findings suggest that loss of BDNF in forebrain contributes to some aspects of depression-like behavior in a complex manner with gender. The finding that BDNF deletion in males was not sufficient to produce alterations in many behaviors examined suggests that the neurotrophic hypothesis related to depression is more complicated than simply that loss of the gene triggers depression. The loss of forebrain BDNF increased vulnerability in aspects of depression-related behaviors in females after CUS suggesting a role for BDNF in mediating features of depression-related behavior in females.
We appreciate the excellent assistance of Nicole Buzin and Jennifer Winn. We thank Dr. Waseem Akhtar for helpful discussions. This work was supported by grant MH070727 (L.M.M) as well as the Division of Basic Sciences Training Program at UT Southwestern Medical Center T32 DA07290 (A.E.A).
Financial Disclosure
The authors report no biomedical financial interests or potential conflicts of interest.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Date: 1968
Description: "Shirley Borgman Widmer."
Date: 1953-06
Description: Carol Frings and Dick Ouellette wedding. Father Skalitzke presides over the ceremony.
Date: 1996-10
Description: Chelsey and Logan Wilz explore McArthur Road.
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Description: "Theresa water tower base."
Date: 1978-02-24
Description: "Sportsmen's Bar — Ed Lenz, Prop."
Date: 1979-09
Description: The Ziemer auction is being held at the Dog's farm on County P.
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Description: "Theresa Public School Library."
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Description: "For pumping out the milk at each farm, a small gas engine was used to power the truck's pump. Myron Weninger checks the pump on the Widmer Cheese bulk tru...
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Jim Widmer's "Spirit of Rural Wisconsin," Part I
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Definition of Scotticize in English:
(also Scotticise)
verb[with object] rare
Make Scottish in character: the Scandinavian name Sigurdsson was Scotticized as Stewartson
More example sentences
- Settling in Scotland, he changed his name from Gecevicius and 'Scotticised' his life, giving his children British names.
- That is one reason why he has not 'Scotticised' certain words.
For editors and proofreaders
Line breaks: Scot¦ti|cize
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= trending


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The UN said Tuesday the number of children impacted by Syria's war has doubled in the past year to 5.5 million, many of them trapped in besieged areas and beyond reach.
In a report entitled "Under Siege — the devastating impact on children of three years of conflict in Syria," the UN children's agency UNICEF warns that the situation was likely to get worse.
"Cut off from aid, living in rubble and struggling to find food, many Syrian children have been left without protection, medical care or psychological support, and have little or no access to education. In the very worst cases children and pregnant women have been deliberately wounded or killed by snipers," the report says.
It said a million children are now trapped in areas of Syria that are under siege or that are hard to reach with humanitarian assistance, while some two million children are in need of psychological support or treatment.
"For Syria's children, the past three years have been the longest of their lives. Must they endure another year of suffering?" UNICEF executive director Anthony Lake says.
More from GlobalPost: Syria's other 'weapons' of war: Starvation and sickness
The report focuses on the immense damage caused to children affected by the conflict, including "the accounts of children whose lives have been devastated by the three year old war, and highlights the profound traumas many have experienced."
It warns that "the future of 5.5 million children inside Syria and living as refugees in neighboring countries hangs in the balance as violence, the collapse of health and education services, severe psychological distress and the worsening economic impact on families combine to devastate a generation."
In host countries, 1.2 million Syrian children are now refugees living in camps and overwhelmed host communities, and have limited access to clean water, nutritious food or learning opportunities.
UNICEF estimates that one in 10 refugee child is now working and one in every five registered marriages of Syrian females in Jordan is a child under the age 18.
Jordan is home to more than 500,000 Syrian refugees.
"This war has to end so that children can return to their homes to rebuild their lives in safety with their family and friends. This third devastating year for Syrian children must be the last," said Lake.
Watch Dr. Nancy Snyderman reporting live from a Lebanese hospital that treats Syrian refugees from surrounding camps at noon (via NBC News):


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- Jul 20, 2016 | Black Enterprise Help That Can Make a Big Difference (If You Know About It) Microgrants help to retain students and get them to graduate CLASP cited in this article with a caution about ensuring that a microgrant isn't really a microloan.
- Jul 18, 2016 | Next City Building a Better Summer Jobs Program for America's Youth This article cites a 2007 report by CLASP about the value of the summer jobs program for youth.
- Jul 14, 2016 | Bridge Magazine Businesses gain from stable child care, but what are they doing about it? Nationwide, the program is underutilized as well, said Hannah Matthews, director of child care and early education for the CLASP, a Washington D.C.-based advocacy group concentrating on antipoverty policy for children and families.
- Jun 23, 2016 Statement: Split Supreme Court Leaves DAPA, Expanded DACA Hold in Place, Fails to Address Harm to Children Statement from CLASP on the case of U.S. v. Texas on DAPA/DACA
- Feb 17, 2016 New Analysis of Access to Child Care Subsidies, Head Start Finds Disparate Access by Race, Ethnicity, and State In a unique analysis released today, CLASP found that access to child care subsidies and Head Start is sharply limited for all eligible children, even more so for particular racial and ethnic groups and in particular states.
- Feb 11, 2016 CLASP Statement: President Obama's Budget Invests in 'Opportunity for All'
- Feb 08, 2016 Official Finding of Civil Rights Concerns in Mississippi Child Care Assistance Program Should Serve as a Call to Action in Mississippi and Nationally Statement from CLASP
CLASP's policy experts present at a wide variety of events, conferences, seminars and forums throughout the country. Following are upcoming CLASP staff presentations:


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The Secular Humanist Group of Alberta (Calgary) Message Board › LogiCon
|Timothy M.
user 22103681
Edmonton, AB
Just want to make sure everyone knows about LogiCON 2013. Sounds like a blast. Full disclosure: I'm talking there. I'll be in the family track. If you attend, say hi and let me know you're from this group.
Meetup members, Log in
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text:
Ben McLemore's AAU coach Darius Cobb talks with Linda Cohn and Danny Kanell about his relationship with McLemore, why he accepted payments for sports agents and his influence over McLemore.
Vote: Which Big Ten venue is the toughest place to play?
1hESPN.com staff
Vote: Which ACC venue is the toughest place to play?
22hESPN.com staff
Which lesser-known prospects got noticed in July?
1dJeff Borzello
Center Nick Richards hopes to raise his stock in Las Vegas
4dJeff Borzello
Five-star Collin Sexton names top 10
8dPaul Biancardi
Scout's Take: Washington lands top-five prospect Michael Porter Jr.
10dPaul Biancardi
Indiana under pressure to land in-state prospects in 2017
11dJeff Borzello
Miles Bridges hits his head on a rim during pro-am
13dMyron Medcalf
Post-Peach Jam recruiting updates for 2017's top 10 prospects
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Top performers from Nike Peach Jam
15dAdam Finkelstein and Reggie Rankin
Watch: Wrapping up the action at Peach Jam
16dESPN.com staff


text:
A huge meteorite exploded over Russia Friday morning in a burst of light and thundering boom that blew out windows and damaged some buildings. Many Russians captured the event on camera.
Related Stories
( T. Charles Erickson )
Review: 'Satchmo' goes behind Louis Armstrong's happy facade
The solo show 'Satchmo' by Terry Teachout depicts jazz legend Louis Armstrong reflecting on his bittersweet life and music; it plays at American Conservatory Theater through Feb. 7
(AP Photo/Lennox McLendon)
Ice Cube co-producing 'Hip Hop Squares'
Ice Cube bringing 'Hip Hop Squares' to VH1.


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Apr 5, 2013
Flush Profile
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Guest list released for Thatcher funeral
She should go out with an honor. She was not only a good politician, but a role model for many women today. It wouldn't be right if dignitaries the world over didn't show up! (Apr 11, 2013 | post #1)
Beyonce and Jay-Z's Trip to Cuba - Connecting the Dots
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White House celebrates the sounds of Memphis soul
I wonder who they were highlighting that type of music to? We all would like to go to concerts. We just can't afford the high cost of the tickets. (Apr 9, 2013 | post #5)
Pilot texting a factor in deadly copter crash
Pilots texting? I thought you were supposed to have your cell phone turned off while you were in the plane. Do you even get a good signal when you are way up in the air? (Apr 9, 2013 | post #1)
3-year-old fatally shoots deputy's wife with his gun at T...
I am sure there is more to this story. Of course, a deputy is allowed to legally possess a gun, so a gun law would not have helped in this situation. (Apr 9, 2013 | post #2)
Reagan, Thatcher forged a close, lasting bond
Why did I not realize that Margaret Thatcher was 87 years old? I think Germany's Angela Merkel is following in her footsteps. She is a woman of much power in Europe right now! (Apr 9, 2013 | post #3)
Maryland lawmakers pass medical marijuana bill
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What song are you listening to right now?
I am listening to Queens Of the Stone Age's, "A Song For the Deaf". They are coming out with a new album this year. I can't wait for it! (Apr 7, 2013 | post #99338)
I love Toyota vehicles. It is just hard to get a good job these days, though. At the plant, you probably have to prove yourself before they will hire you. That might be why they make you work as a temp for a while, before they hire you. (Apr 7, 2013 | post #355)
Hundreds of birds die in western Ky.
If the wildlife are dying, that might mean that there is pollution in the air. It might not be safe for humans, either, and should be tested. (Apr 7, 2013 | post #88347)
What Makes Someone Who They Are?
Sometimes a person can be remembered by the clothes that they wear, or the scent of their perfume. Right now, my style is similar to the T-shirts I have found on spncolors.com. I also use their natural olive oil soaps, so I hope that I will be remembered by my scent. (Apr 7, 2013 | post #5)
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Brent Richey
Revolving Door
Who's coming and who's going. Tell us about your job move! Receive the Revolving Door Newsletter with expert analysis by email twice a week.
May 7, 2013: Brent Richey has been named senior account executive, Southwest, at Tapad. He had been senior national account executive at AT&T AdWorks. (mb)
April 23, 2008: Brent Richey has been named media planner and supervisor at Moroch Partners. He had been media planner at T:M Advertising. (mb)


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I would have thought that this would have been covered before, but I searched for most strings that I could imagine that relate to the topic, and couldn't find anything.
I created a plugin that takes a Picasa exported gallery and displays it on a post, just by using the add_filter api hook. The gallery is constructed of thumbnails on the main page, and then each thumbnail links to the full size image.
I'd like to make this a little bit more sophisticated now and have the thumbnail link to another page that maintained the theme of the site, displayed the image in the correct location, based on the theme itself and also some previous and next buttons to link to the corresponding images.
I'd like to do it "within" WordPress. That is, have a custom template page, say image.php in the template directory, and just link to http://www.site.com/?image=file (or a corresponding URL that makes use of the rewrite rules) and have WordPress automagically know to use the image.php template file.
I've had a quick glance through the source, but I thought I'd find out if it's possible without hacking up WordPress. I'd like to do it without hacking, but if I had to, then I guess I can, but that makes it less useful for the general public, and I know of a few people that'd like to use it for their own site.
Any ideas?


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The upcoming
transition plan and progress of 5th and 6th graders
moving to Junior High next year will be discussed and school leaders will provide answers to questions you may have
regarding the transition. Parents with students in all grade levels are
welcome to attend. Childcare will not be provided.
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