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More than 18 million Americans are served drinking water by providers that have violated federal laws concerning lead in water, with only a tiny proportion of offenses resulting in any penalty, a new report has found.
The toxic water crisis in Flint, Michigan, is "not anomalous", the Natural Resources Defense Council (NRDC) report states, with widespread violations of national rules designed to protect people from lead, a known neurotoxin that is harmful even in small doses.
Millions exposed to dangerous lead levels in US drinking water, report finds
More than 18 million Americans are served drinking water by providers that have violated federal laws concerning lead in water, with only a tiny proportion of offenses resulting in any penalty, a new report has found.
Chamber of Commerce rips Trump's trade speech in real time
The U.S. Chamber of Commerce answered Donald Trump's trade policy speech on Tuesday by attempting to pick apart the presumptive Republican nominee's policies point by point, engaging in a rapid-fire succession of social media posts hitting him for his opposition to international trade deals.
In a post published before Trump took to the stage at a raw aluminum producer in Monessen, Pennsylvania, the chamber laid out the stakes for trade in both Pennsylvania and in Ohio. (The Republican is set to hold a rally in St. Clairsville, Ohio later Tuesday evening.)
Supreme Court spurns abortion restrictions in two more states
Reverberations from the U.S. Supreme Court's major ruling backing abortion rights were felt on Tuesday as the justices rejected bids by Mississippi and Wisconsin to revive restrictions on abortion doctors matching those struck down in Texas on Monday.
The laws in Mississippi and Wisconsin required doctors to have "admitting privileges," a type of difficult-to-obtain formal affiliation, with a hospital within 30 miles (48 km) of the abortion clinic. Both were put on hold by lower courts.
NASA reveals solar system Internet for interplanetary communication
A new system deployed by NASA is expected to help the development of an interplanatery space communications system that functions much like the Internet does on Earth.
NASA installed software on the International Space Station to make communication faster and easier, and it is expected to lead to an Internet system that may cover the entire solar system in the future, the agency announced.
Benghazi report faults security; no new Clinton allegations
Republicans on the House Benghazi Committee harshly faulted the Obama administration Tuesday for lax security and a slow response to the deadly 2012 attacks at the U.S. diplomatic outpost in Libya. But they produced no new allegations about then-Secretary of State Hillary Clinton.
The attacks, which killed four Americans, including U.S. Ambassador Chris Stevens, have been repeatedly cited by Republicans as a serious failure by the administration and by Clinton, who now is the presumptive Democratic nominee for president.
Trump silent on landmark Supreme Court abortion ruling
At about 10 o'clock Monday morning, shortly after the Supreme Court issued its 5-3 ruling striking down a Texas law that would have closed half the abortion clinics in the state, Hillary Clinton sent out a couple of tweets.
"SCOTUS's decision is a victory for women in Texas and across America. Safe abortion should be a right — not just on paper, but in reality," the first one read.
Minutes after that, she followed up with, "This fight isn't over: The next president has to protect women's health. Women won't be "punished" for exercising their basic rights." Both were signed "-H," meaning she wrote them herself.
Dems release parallel Benghazi report ahead of GOP
Democrats on the House Select Committee on Benghazi released their rebuttal to the Republican-led committee's argument on Monday, before the GOP leaders published their own report.
The 339-page Democratic report aims to refute allegations expected to be made by Chairman Trey Gowdy (R-S.C.) in what they have long claimed is a partisan witch hunt.
Supreme Court strikes down Texas abortion clinic regulations
The Supreme Court has struck down Texas' widely replicated regulation of abortion clinics in the court's biggest abortion case in nearly a quarter century.
The justices voted 5-3 Monday in favor of Texas clinics that protested the regulations as a thinly veiled attempt to make it harder for women to get an abortion in the nation's second-most populous state.
U.S. Supreme Court Backs Gun Curbs in Domestic-Violence Cases
The Supreme Court ruled in a decision announced Monday that a reckless domestic assault qualifies as a misdemeanor crime of domestic violence, and therefore bars individuals from owning or buying guns under federal law.
"A person who assaults another recklessly 'use[s]' force, no less than one who carries out that same action knowingly or intentionally," wrote Justice Elena Kagan, who authored the majority opinion. She was joined by Chief Justice John Roberts, as well as Justices Anthony Kennedy, Ruth Bader Ginsburg, Stephen Breyer and Samuel Alito.
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Oliver is unbroke 9 year old tb when he came me he was under weight and his feet had not been done. His feet have now been done and his weight is good…$100
"Rolex" is a 3 year old, 16.1 hand branded Holsteiner. He was started under saddle last September, 2015. Had 30 days training, stands at mounting block…$12,000
Theo is a 4 year old registered welsh gelding. Son of Liseter Cadert. Very fancy, big stride. Would be a darling short stirrup, childrens, or small pony…$2,000
Friendly mare.... Goes English and Western. We Started her over fences. Full of potential! She really will do anything you ask of her. Very levelheaded…$6,000
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Nov 10, 2009
|Priority date
|Mar 23, 2000
|Fee status
|Also published as
|Publication number
|Clifton A. Alferness, Hugo X. Gonzalez
|Original Assignee
|Spiration, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (14), Referenced by (1), Classifications (9), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a continuation of U.S. application Ser. No. 10/287,188, filed on Nov. 4, 2002, now U.S. Pat. No. 6,790,172 which is a continuation of U.S. application Ser. No. 09/780,232, filed on Feb. 9, 2001, now U.S. Pat. No. 6,485,407, which is a continuation-in-part of U.S. application Ser. No. 09/534,244 filed Mar. 23, 2000, now U.S. Pat. No. 6,328,689, the entirety of which is incorporated herein by reference.
The present invention is generally directed to an apparatus and method for resectioning body tissue. The present invention is more particularly directed to such an apparatus and method which may be used on various types of body tissue and which greatly simplifies resection procedures.
Chronic Obstructive Pulmonary Disease (COPD) has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, through lung volume reduction surgery (LVRS), the force could be partially restored. Although the surgery was deemed promising, the procedure was abandoned.
Lung volume reduction surgery was later revived. In the early 1990's, hundreds of patients underwent the procedure. However, the procedure has fallen out of favor due to the fact that Medicare stopped remitting for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. However, what data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life.
Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricular filling.
The improvements in pulmonary function resulting from LVRS cannot be ignored. However, the surgery is very invasive and fraught with complications. Among the complications is the potential for lung air leaks. Lung tissue is very thin, and fragile hence difficult to suture together. After a lung portion is sectioned and removed, the remaining lung is most often restructured with suture staples. In about thirty percent (30w) of the cases, the difficulty with suturing lung tissue results in air leaks. Treatment for such air leaks depends upon their severity and often, in the most serious cases, requires further open chest surgery.
Air leaks in lungs can be caused by other causes. With increasing age, a patient may develop a weakened section of lung which may then rupture due to an extreme pressure differential, such as may result from simply a hard sneeze. Patients with AIDS and pulmonary complications can suffer from air leaks. Air leaks in lungs can further be produced by direct trauma such as a puncture from a broken rib or a stab wound.
The invention disclosed and claimed in copending U.S. Pat. No. 6,328,689 B1 provides an improved therapy for treating COPD. The improved therapy includes a lung constriction device and method for suppressing such air leaks in lung tissue which does not require any suturing of the effected lung tissue. Still further, by constricting a large enough portion of a lung, lung volume reduction with the concomitant improved pulmonary function may be obtained without the need for any suturing of lung tissue at all.
More specifically, the lung constriction device includes a jacket of flexible material configured to cover at least a portion of a lung. The jacket has a pair of opened ends to permit the lung portion to be drawn into the jacket. The jacket is dimensioned to constrict the lung portion after the lung portion is drawn therein. The lung constriction device is preferably formed of expandable material for receiving the lung portion when forced into an expanded enlarged condition by an expansion force, and then contractible about the lung portion upon release of the expansion force for constricting the lung portion.
An important aspect of the device and method disclosed in U.S. Pat. No. 6,328,689 B1 is the ability to sever the constricting device intermediate its ends. This allows a significant portion of the constricted lung tissue to be removed altogether while permitting a portion of the constricting device to remain in the body for continued suppression of air leaks and maintenance of the remaining lung tissue integrity.
Devices and methods similar to those disclosed in U.S. Pat. No. 6,328,689 B 1 may be employed to advantage in other and different procedures such as in general resection procedures and for body tissue. Resection procedures are commonly performed for such body tissue as, for example, atrial appendage tissue, ovarian tissue, gall bladder tissue, pancreatic tissue, appendix tissue and spleen tissue. Resection procedures may be required to treat cancer, organ damage, or organ disease, for example.
Common to all resection procedures is the need to isolate the body tissue to be removed, resection the body tissue to be removed, and then suture the incision. All the while, great care must be taken to avoid infection from external sources and from the diseased tissue being removed. Frequent aspiration of blood and other body fluids, some of which may be contaminated, is often essential. The present invention provides an improved method for use in body tissue resection.
The invention therefore provides a method of resectioning body tissue which may find many applications for encapsulation, isolation, and resection of body tissue. More particularly, among its many applications, the present invention may be employed for removal of diseased tissue, nodules and tumors, for example. The method includes the steps of providing a sheath formed of severable material having opposed opened ends, drawing the body tissue other than lung tissue to be resectioned into the sheath to confine and constrict the soft tissue within the sheath, and severing the sheath and the body tissue within the sheath intermediate the opposed opened ends of the sheath.
The invention further provides a device for use in resectioning body tissue. The device comprises a sheath of severable material, the sheath having a pair of opened ends for receiving the body tissue and the sheath being dimensioned for containing and constricting the body tissue.
The invention further provides a system for resectioning body tissue. The system includes a sheath of severable material, the sheath having a pair of opened ends for receiving the tissue and the sheath being dimensioned for containing and constricting the tissue, means for drawing the tissue into the sheath to constrict and isolate the tissue, and means for severing the sheath to resection the tissue.
The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify identical elements, and wherein:
Referring now to
The respiratory system 20 includes the trachea 28, the left mainstem bronchus 30, the right mainstem bronchus 32, and the bronchial branches 34, 36, 38, 40, and 42. The respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56, 58, and 60. Each bronchial branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof.
A healthy respiratory system has an arched or inwardly arcuate diaphragm 26. As the individual inhales, the diaphragm 26 straightens as illustrated in
In accordance with one embodiment of the present invention, the sheath is applied to the portion of the lung lobe having the leak or puncture while the jacket is in an expanded condition. This may be accomplished, as will be seen hereinafter, by expanding the jacket and then pulling the lung portion into the jacket. When the effected lung portion is thus disposed with respect to the sheath as illustrated in
In accordance with a further embodiment, if the flexible sheath is nonexpandable, the lung tissue may be collapsed as it is pulled into the jacket. Once disposed in the sheath, the lung tissue will remain constricted by the sheath.
When the lung portion is thus constricted, the air leakage will be suppressed. The lung lobe 58 thereafter, during successive breaths, will reinflate and become functional once again to support respiration.
The use of the device 70 need not be restricted to the suppression of air leakages in lungs. It may, for example, find use to advantage in constricting a lung portion suffering from COPD to simulate or achieve lung volume reduction. All of the beneficial effects of lung volume reduction surgery may be realized and, most importantly, without requiring suturing of lung tissue.
In accordance with this embodiment, the form 80 is hollow, has opened ends 82 and 84 and has a configuration similar to that of the device 70. In addition, the form has a longitudinal slit 86 rendering the form expandable in a transverse direction. The form further includes tabs 88 and 90 which, when pressed towards each other, cause the form to expand in the transverse direction.
The device 70 is applied to the form 80 until the end 74 of the device 70 is at the end 84 of the form 80 as illustrated in
The forceps 92 are then used to grab the lung tissue 58. Then, the tabs 88 and 90 of the form 80 are pressed toward each other to cause the form 80 to expand in a transverse direction. This may be noticed by the longitudinal slit 86 becoming noticeably wider. The expansion of the form 80 in the transverse direction imparts an expansion force on the device 70, causing it to similarly expand to an expanded condition. With the device 70 thus expanded, the forceps are then retracted as illustrated in
The process continues as illustrated in
As illustrated in
Alternatively, the form 80 need not be expandable if the device 70 is not expandable. Here, the process of pulling the lung tissue into the mandrel 80 and device 70 will cause the lung tissue to collapse. With the device 70 being dimensioned for constricting the lung tissue, once the mandrel is removed, the lung tissue will remain in and be constricted by the device 70 as illustrated in
The lung tissue within the device 70 is also now ready to be resectioned. This may be accomplished by severing the device 70 intermediate it's ends using an appropriated bladed instrument.
As will be noted in
The form 110 has a diameter dimension 126 which is substantially greater than the diameter dimension of the device 70 when the device is expandable and in a nonexpanded condition. As seen in
Referring now to
After the lung tissue 58 has been pulled into the form 110 and the device 70, the device may be held in position and the form 110 withdrawn from the device 70 and the lung tissue 58. When this is completed, as best seen in
Again, the device 70 need not be expandable. To that end, the form 110 may have the same or approximately the same dimensions as the device 70. When the vacuum suction pulls the lung tissue 58 into the mandrel or form 110, it will collapse. After the vacuum suction is terminated and the mandrel 110 removed, the lung tissue 58 will remain in the device 70 in a collapsed condition to be constricted by the device 70. The lung tissue within the device 70 is also ready to be resectioned. Again, this may be accomplished by severing the device 70 intermediate its ends by use of an appropriate bladed instrument.
As illustrated in
Now, when the lung tissue 58 is brought into engagement with the end 74 of the device 70 and the vacuum is pulled with the closure of valve 120, the lung tissue is pulled directly into the device 70 as illustrated in
After the lung tissue 58 has been pulled into the device 70, the end 74 of the device 70 may be released from the lip 130 of the form 110 to permit the form 110 to be withdrawn from the device 70. When this is completed, as best seen in
Once again, the device 70 need not be expandable. To that end, the form or mandrel 110 may be of the same dimension or slightly larger dimension than the device 70 to permit an effective seal between the lip 130 of mandrel or form 110 and the end 74 of the device 70. The vacuum suction will still be pulled through the form 110 and the device 70. As the vacuum suction pulls the lung tissue into the device 70, the lung tissue collapses. When the vacuum is released and the form 110 is removed, the collapsed lung tissue will remain constricted in the device 70 to provide, for example, lung leakage suppression or lung volume reduction.
Referring now to
In accordance with this embodiment, the device 70 is formed of severable material, such as, any of the materials previously described. This enables the device 70 to be severed or cut intermediate its ends with a suitable bladed instrument 61 as illustrated in
Referring now to
Once the device 70 is deployed as illustrated, the tissue 74 constricted within the device 70 and to be resectioned is resectioned as illustrated in
As can thus be seen, in accordance with the present invention, resectioning of the heart may be accomplished without suturing by use of the constriction and resection device 70. This will greatly assist in accelerating the healing process and reducing the potential for infection.
Referring now to
Once the device 70 is deployed as illustrated, the tissue 84 constricted within the device 70 and to be resectioned is resectioned as illustrated in
Referring now to
Once the device 70 is deployed as illustrated, the gall bladder tissue 94 constricted within the device 70 and to be resectioned is resectioned as illustrated in
Referring now to
Once the device 70 is deployed as illustrated, the tissue 104 constricted within the device 70 and to be resectioned is resectioned as illustrated in
Once the device 70 is deployed on the appendix as illustrated, the appendix tissue 140 constricted within the device 70 and to be resectioned is resectioned as illustrated in
Referring now to
Once the device 70 is deployed as illustrated, the tissue 154 constricted within the device 70 and to be resectioned is resectioned as illustrated in
As can thus be seen, in accordance with the present invention, the resectioning may be accomplished without suturing by use of the constricting and resection device 70. This significantly simplifies resectioning procedures. For example, since a vacuum may be utilized to pull the tissue to be resectioned into the device, the area is also aspirated at the same time. This assists in preventing contamination and infection. Also, there is no resulting opened wound by virtue of the resection. This again lends to assist in preventing infection. Resection is rendered substantially an automated procedure since the procedures for deploying the device may be automated. Hence, the present invention provides an improved device and method which may be used to advantage for resectioning body tissue.
While the invention has been described by means of specific embodiments and applications thereof, it is understood that numerous modifications and variations could be made thereto by those skilled in the art without departing from the spirit and scope of the invention. It is therefore to be understood that within the scope of the claims, the invention may be practiced otherwise than as specifically described herein.
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|Citing Patent
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|Mar 15, 2016
|Spiration, Inc.
|Tissue resection device, system, and method
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Oct 19, 2010
|Certificate of correction
|Jan 4, 2011
|Certificate of correction
|Nov 9, 2011
Owner name: SPIRATION, INC., WASHINGTON
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ALFERNESS, CLIFTON A.;GONZALEZ, HUGO X.;REEL/FRAME:027249/0284
Effective date: 20010209
|Jan 24, 2012
|Reissue application filed
Effective date: 20111109
|May 9, 2013
|Fee payment
Year of fee payment: 4


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Dear community members:
As of June 30, 2013 the Crookston Area Community Fund (CACF) will have run out of time to reach its first Crookston Area Community Fund endowment goal of $50,000. Will you be the one to take the fund over the top? Every one of the donations made before the first goal deadline of June 30th is reached will be fully matched by the Otto Bremer Foundation and also matched with an additional 10 percent by the Northwest Minnesota Foundation. Your gift at this time could be worth 210 percent to CACF.
With the encouragement of the Otto Bremer Foundation and the Northwest Minnesota Foundation, Crookston, along with four other communities, has been selected to host an endowed community fund. Over time, with the generosity of people like you, the endowment and available grant funds will continue to grow and become a permanent source of support for projects that are an enduring part of Crookston's future. Already CACF grant funds have been contributed towards six important community projects or services, and in the coming months CACF will announce another grant round opportunity.
Become a part of Crookston's future and help CACF to Create Crookston through your contribution to the Crookston Area Community Fund. Donations of any size will help us reach this goal and may come from individuals, organizations, or businesses.
Thank you to those that already made a contribution:
- Allan and Judy Dragseth
- American Federal Bank of Crookston
- Andrew Svec
- Bernie Lieder
- Bremer Bank of Crookston
- Bud and Judy Ellingson
- Colleen and Ian MacRae
- Crookston Development Authority
- Crookston Implement Company
- Crookston National Bank
- Dale Halos
- Dan and Laurie Wilson
- David and Linnea Genereux
- Dennis Koch
- Donald and Mary Beth Sargeant
- Dr. Chalres H. Casey and Barbara Muesing
- Erickson Family Dental PA
- Fred and Mary Wood
- Gayle and Bob Nelson
- Jan Charchenko
- Jan Cole
- Jason and Kerri Brantner
- Jerome Knutson
- Jim and Michelle Snyder
- John and Jan Vallager
- John and Lacy Bridgeford
- Kathleen Anderson
- Lisa and John Peterson
- Lois Bagley
- Mary and Don Cavalier
- Mary Ann and Dale Knotek
- Mid-Valley Grain Cooperative
- Noel and Mary Rusling
- Otter Tail Power Company Crookston
- Polk County DFL
- RiverView Healthcare Association
- Sandi and Jim Kent
- Tim and Marlene Dufault
- Titan Machinery
- Tom and Michal Jorgens
- Vance and June Schipper
- Vicki Melbye
- Wayne and Nancy Capistran
- Widman's Candy Shop
- William Anderson
Page 2 of 2 - Donations may be sent directly to CACF, PO Box 543, Crookston, MN 56716, or dropped off with any CACF Board Member. Thank you for your consideration of this request.
CACF Advisory Boardvmembers:
Dave Genereux, Jim Snyder, Andrew Svec, Bill Anderson, Dale Knotek, Tom Jorgens, Angel Hoeffner, Allan Dragseth, Dennis Koch, Betty Arvidson, Colleen MacRae, Craig Morgan, and Laurie Wilson
Location, ST | website.com


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July 24, 201611:57 AM ET
WASHINGTON (AP) — Hacked emails threatened to overshadow the Democratic Party's upcoming celebration in Philadelphia as progressives expressed disappointment Sunday over the presidential nomination process and Bernie Sanders stepped up demands that the party's chairwoman step down.
July 24, 201612:03 PM ET
LAUSANNE, Switzerland (AP) — Olympic leaders stopped short Sunday of imposing a complete ban on Russia from the Rio de Janeiro Games, leaving individual global sports federations to decide which athletes should be cleared to compete.
July 24, 20161:25 PM ET
LAUSANNE, Switzerland (AP) — The Latest from the IOC meeting on Russia's participation at the Rio Games (all times local):
July 24, 20169:05 AM ET
KABUL, Afghanistan (AP) — Afghanistan marked a national day of mourning on Sunday, a day after a suicide bomber killed at least 80 people who were taking part in a peaceful demonstration in Kabul. The attack was claimed by the Islamic State group.
July 24, 20166:06 AM ET
KABUL, Afghanistan (AP) — After two years of heavy casualties, the Afghan military is trying to retake the initiative in the war against militants with a new offensive against Islamic State group loyalists, an assault that will see American troops back on the battlefield working more closely with Afghan soldiers.
July 24, 20161:17 PM ET
CHICAGO (AP) — The Chicago White Sox have suspended ace Chris Sale five days without pay for destroying collared throwback uniforms the team was scheduled to wear.
July 24, 20161:08 PM ET
July 24, 20161:25 AM ET
CHICAGO (AP) — Chicago White Sox ace Chris Sale was scratched from his start against the Detroit Tigers on Saturday night and sent home after he destroyed collared throwback uniforms that the team was scheduled to wear.
July 24, 201612:54 AM ET
NEW YORK (AP) — Mac Williamson had crossed paths with Ivan Nova before.


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Thirty-two teams, 32 burning fantasy questions. Throughout the preseason, we put one of these questions to an ESPN.com analyst for an in-depth look at the most interesting, perplexing or dumbfounding fantasy facet of each NFL team. Be sure to check out all 32 questions.
Larry Johnson is finally signed, sealed and delivered, but is he capable of repeating his 2006 season?
From all the negative talk about Johnson this spring in fantasy circles, you'd think he was some 30-year-old back teetering on the edge of retirement. This is an incredibly big, fast and talented guy who's never been injured, and since he started getting the ball in the middle of 2005 he's done nothing other than rush for over 1,700 yards and 18 scores a season. There's no question LJ totes more risk with him this year than some of the other top fantasy backs. But when the dust settles, he'll exceed 1,600 yards rushing again, and score upwards of 15 touchdowns.
I'll be the first to admit the deck looks a bit stacked against Johnson. First off, there's the offensive line, which lost All-Pro guard Will Shields to retirement this year and Hall of Fame tackle Willie Roaf to retirement last year. The key guy in '07 is Damion McIntosh, who signed a big-money deal to be Roaf Jr. in this offense, but then hurt his knee in camp and will miss the entire preseason. If he doesn't get right, the Chiefs have a whole lot of nothing to replace him. However, if you make the assumption McIntosh will be OK, this line will still be above average, and rather peeved at the lack of respect it's received this offseason. Brian Waters (30), Casey Wiegmann (34) and John Welbourn (31) are grizzled by NFL standards, but they comprise what should be an intimidating interior line. Welbourn is a natural guard who was forced to play tackle last season (after he returned from a drug suspension), Wiegmann hasn't missed a game at center in six years, and Waters is a three-time Pro Bowler who had a 79 consecutive games-played streak halted by a knee injury late last season (he's healed). Get McIntosh back (and it's expected the Chiefs will), and this team's line problems are vastly overstated.
Next, there's LJ's workload, and it's been prodigious. He set a single-season record for carries last season, with 416, and there's good statistical evidence that backs who undergo that kind of punishment in a season are often never the same thereafter. Then again, LaDainian Tomlinson was second in carries last year (albeit at 348), and he has 1,158 more career carries than Johnson. Plus, unlike LJ, LT actually has gotten hurt before, and LJ basically has three years' less wear on him. No, I'm not arguing Johnson should be ahead of Tomlinson (in fact, I'm the guy who argued for LT last year), but I'm saying you can make statistics say an awful lot of things, and not all of 'em are true. LJ's going to take punishment this year, and he's going to get hit a lot in the backfield, and he's going to slow down eventually as a result. I just don't think it's a fait accompli that the slowdown happens this season. In fact, Johnson's massive-carry season came so early in his career, I believe the slowdown won't happen in '07. Heck, I'll agree that this huge contract Johnson just signed will probably come back and bite Kansas City. But not this season.
Next on the concern list come the quarterback situation in Kansas City and the contract holdout. Hey, there's not much I can say to defend the QB situation except to say that Curtis Martin had a couple pretty darned good seasons playing for Herm Edwards when teams pretty much knew all Herm wanted to do was run, and all Chad Pennington could do was hoist softies. Brodie Croyle should be a traffic wreck of a quarterback, and it would certainly be better for LJ if Damon Huard won the job. Either way, though, Herm's going to run, Johnson's going to get stuffed a bunch, but then he's also going to break out a few times a game. And as for the holdout? Please. Ask Emmitt Smith circa 1993 how badly holdouts affect a running back; in 14 games, he rushed for 1,486 yards (for a 5.3 yards-per-carry average). If anything, LJ's rested. By the way, I don't think there's a need to take the Priest Holmes comeback seriously.
I admit it: This column reads like an apologia, and I suppose that's what it is. There are a quite a few things that can go wrong with Larry Johnson in 2007. But what gets lost in all the quibbling about circumstance and surrounding cast is that this guy is a supremely talented back with startlingly few miles on his odometer. He's come a long way from Dick Vermeil's diapers. I believe talent will win out, and there's still nothing scarier than playing against LJ's fantasy team and seeing him get near the corner on the opponent's 15-yard line. He's going in. So, will he exactly match last season's 1,789 rushing yards and 17 scores? Maybe not. But it's going to be darned close.
Christopher Harris is a fantasy baseball, football and racing analyst for ESPN.com.
You can e-mail him here.


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EDDMapS Distribution - This map is incomplete and is based only on current site and county level reports made by experts, herbaria, and literature. For more information, visit www.eddmaps.org
|Kingdom: Plantae
|Phylum: Magnoliophyta
|Class: Magnoliopsida
|Subclass: Rosidae
|Order: Rosales
|Family: Pittosporaceae
|Genus: Pittosporum
|Subject: Pittosporum undulatum Vent.
Other Common Names:
mock orange, sweet pittosporum, Victorian box, Victorian laurel


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Il Borgo dell'Orso, Molise
- Free parking
Main amenities
- 8 guestrooms
- Tour/ticket assistance
For families
- Rollaway/extra beds available
- Private bathroom
- Hair dryer
- Bathtub or shower
- Free self parking
What's around
- Altilia Archaeological Site (22.1 mi / 35.5 km)
- Museo Provinciale Sannitico (22.9 mi / 36.9 km)
- Marinelli Bell Foundry Museum (23.3 mi / 37.4 km)
- Agnone Piazza Vittoria Monumento Ai Caduti (23.3 mi / 37.6 km)
- Castello Monforte (23.4 mi / 37.6 km)
Il Borgo dell'Orso, Molise
Hotel Info: 866-539-8117
- Double Room
- Single Room
- Standard Room, 2 Single Beds
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 8 rooms
- Check-in time starts at 4 PM
- Check-out time is 10 AM
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
Extra people
- Roll-away beds available, charges may apply*
- Free self parking
In the hotel
- Tours/ticket assistance
In the room
- Private bathroom
- Bathtub or shower
- Hair dryer
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Il Borgo dell'Orso, Molise's small print
Also known as
- Il Borgo dell'Orso
- Il Borgo dell'Orso Frosolone
- Il Borgo dell'Orso House
- Il Borgo dell'Orso House Frosolone
Cash transactions at this property cannot exceed EUR 2999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation.
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Rollaway beds are available for EUR 10 per night
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Local News
Kyle Braddy of South College will be sentenced on June 21st following a pre-sentence investigation. Judge Michael McHaney revoked Braddy's bond following the guilty verdict and sent him to jail. The jury deliberated about an hour and a half before announcing their verdict.
Braddy faces four to 15 years in prison on the criminal sexual assault charge and three to seven years on each of the aggravated criminal sexual abuse charges.
Marion County State's Attorney Matt Wilzbach says Braddy was charged with both criminal sexual assault and aggravated criminal sexual abuse to a girl who was then 14 years old and aggravated criminal sexual abuse to a girl who was 13 years old.
The charges state the sex acts were committed against the girls in the second half of 2011. He said they were family members. Both testified in the trial to the acts against them.
Marion County Sheriff's Department Detective Anthony Decker testified how the investigation by the Department of Children and Family Services began after a family member called the Department's hotline.
Another family member also testified she had been the victim of sexual acts by Braddy.
Braddy and his girlfriend both took the stand and denied the acts could have occurred because of the timeline.
Wilzbach said Braddy had no prior criminal record. He has not decided on what type of sentence to seek.
Braddy's attorney, Mark Tungate, had no comment on the verdict when leaving the courtroom Wednesday following the three day trial.
See other LocalNews news:Purple People Eater Balloon Returning to Balloon Fest
Water and Sewer Rates Going Up in Odin
South Central School Board Appoints New Board Member
Two Injured in Salem Accident
Four Injured in Wayne County Crash


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InvenSense Falls on SanDisk Sales Forecast: San Francisco Mover
InvenSense Inc., which makes motion tracking devices for consumer electronics, fell after SanDisk Corp. cut its sales forecast.
InvenSense slipped 4.8 percent to $17.05 at the close in New York. The shares earlier fell as much as 10.2 percent, the most since last week. They have gained 71 percent this year.
SanDisk, the biggest maker of flash memory cards, said yesterday that it faced weaker than expected pricing and demand for components that store data in mobile phones. InvenSense, which started publicly trading in November, makes products for a similar set of customers, said Auguste Richard, an analyst with Piper Jaffray in Sacramento, California.
"They're in the same neighborhood, and people think it must be bad," said Richard, who has an overweight rating on the stock, meaning investors should buy the shares.
InvenSense's top competitor in making motion-sensing devices is Geneva-based STMicroelectronics NV. That company makes a wider range of products and is able to produce them more cheaply, said Srinivasan Sundararajan, an analyst with Oppenheimer & Co Inc. in New York.
InvenSense's largest customers include Nintendo Co., HTC Corp. and Samsung Electronics Co. HTC and Samsung are competing with Apple Inc. for market share and investors are still waiting for Nintendo's next-generation platform, he said.
"The customers have got problems of their own," said Sundararajan, who downgraded InvenSense to perform, the equivalent of hold, from outperform last week.


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LAUREL, MD-Hampshire Properties has bought the Laurel Square Apartments in Laurel for $102 million. The New York-based company purchased the 982-unit apartment complex at 13301 Arden Way from Fannie Mae and the Bozzuto Group.
The multifamily property was constructed in 1970. It is currently 88% occupied. Andrew Boyer, Bill Roohan, Martha Hastings, Michael Muldowney and Michael Rudolph from CBRE Group Inc. negotiated the deal on behalf of Bozzuto. For the full story, go to Baltimore Business Journal .
GlobeSt.com News Hub is your link to relevant real estate and business stories from other local, regional and national publications.


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All Rise...
Judge David Johnson will stay away from abandoned wells. And creepy dark-haired little girls with monster teeth.
The Charge
Terror goes viral.
Opening Statement
The disc case is eager to notify us that Sadako comes from the writer of The Ring. Yeah, that's obvious within twelve seconds.
Facts of the Case
A disturbing scourge of suicides is plaguing local schools. An online video purportedly of a man killing himself live on the Internet is making the rounds, and anyone who views it, ends his or her own life immediately after. Who is this mysterious man? Apparently he's an infamous airbrush artist. So there's that.
A female high school student eventually finds herself trapped in the cycle of viewing and suicide, as her friends get sucked into the vortex. But who's doing the killing? A freakish girl with dirt black hair who moves all jittery and weird, of course.
The Evidence
Sadako proudly boasts its 3D credentials and if you have the proper equipment you will be able to enjoy multiple exciting scenes like "That hand is reaching out to grab me!" and "That hair is reaching out to grab me!" and "I think that's her kneecap reaching out to grab me!" The 3D gags are pretty obvious and rendered with little verve. The CGI used to pull these gimmicks off leaves much on the table, and will likely distract you more with its amateurishness than any legit ability to frighten.
As far as the frights themselves go, there are a handful of cheap jump scares only two genuinely off-putting moments.
• Our heroine spins around to look for her friend and sees him hung by the neck. This isn't necessarily terrifying except for the weird prop the filmmakers use—an elongated rubber mannequin with an almost comical face. I don't know, somehow it works.
• The first full-on emergence of Sadako from the deadly well. I guess all maniac spirits of dead girls live in wells. She's got the clammy skin, the monster face, and the grimy coiffure going, but bonus points for the hugely oversized legs, turning her into a nightmarish combination of homeless lady and grasshopper.
The final 30 minutes is dedicated to an extensive chase sequence between Sadako and our protagonists. Here, the film transitions from psychological terror to a flat-out creature feature. There are some clever beats, some more jump scares, and a lot of hair. But when it was over, I was just bored.
Well Go USA's Blu-ray is okay, scoring a 1.78:1/1080p transfer with moments of solid clarity, yet often betrays the economical visual effects found within. The darker sequences—essentially the entire finale—have their share of thick grain. Lots of screeching audio cues from the DTS-HD 5.1 Master Audio mix, English subtitles, the 2D version, and no extras.
Closing Statement
Sound and fury and attempts at creepiness, but ultimately Sadako left me disinterested.
The Verdict
Guilty. Here's a Supercuts coupon. Go for it.
Give us your feedback!
Did we give Sadako 3D (Blu-ray) a fair trial? yes / no
What's "fair"? Whether positive or negative, our reviews should be unbiased, informative, and critique the material on its own merits.
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Review content copyright © 2013 David Johnson; Site design and review layout copyright © 2016 Verdict Partners LLC. All rights reserved.


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In 2013, when Catharine Clark moved her eponymous gallery from 49 Geary to the Potrero Hill area, she gave herself more room to work with, including a dedicated media space that has shown indelible work by such artists as Shalo P ("The Bedroom Suite"), Nina Katchadourian ("In a Room Full of Strangers"), and Andy Diaz Hope and Jon Bernson ("Beautification Machines").
The Tenderloin was set to lose another irreplaceable when the Ha-Ra Club — a low-ceilinged dive of the slummiest reputation, long fallen into neglect, but nevertheless beloved for strong pours, idiosyncratic bartenders, and a long history — was taken over by the crew who run Ace's and Dobbs Ferry.
April 02, 2008
Slideshows » Music


text:
Shape Sorting Bath Time Bug
product code: 119793
see more in this range by ELC
Includes a waterwheel and 3 shaped water cups to keep your baby happy in the tub.
Push the shapes into the slots for your baby to catch as they splash into the bath. Show your baby how to fish the pieces out and how to scoop and pour water into the bowls to make the waterwheels turn.
Pour faster and faster to keep the wheels turning.Battery requirements: Not Required
How does this help my child ?
Problem solvingProblem solving
These toys teach your child to work things out for themselves.
ImaginationStimulates Senses
This toy encourages your child to enjoy using their SENSES.
- Weight: 0.3 kg
This product is available for:
Standard Delivery
Normally delivered within 3-5 working days (exclusions apply including postcode restrictions and extended timescales). Exceptional delivery circumstances beyond our control such as bad weather or courier delays may cause your order to take longer to deliver.
FREE for orders over £40, otherwise £3.95
Express Delivery
Order before 4pm for delivery on the next working day to UK mainland addresses. Regrettably this service is unavailable for deliveries to Northern Ireland.
£4.95 on all orders
UK returns
ELC are happy to refund or exchange any unused merchandise returned within 30 days of purchase upon production of your receipt, as long as they are returned in an unused condition and in their original packaging. Please see Terms and Conditions for details. This does not affect your rights if the product is faulty or mis-described.


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The Cooperation Team is looking for 3 members to join our team. This is a volunteer staff position responsible for seeking out fansites attractive to partnership/affiliation with ggFTW, opening dialogue with owners of those fansites, and referring the relationship to management for approval.
Position Requirements:
- Able to commit enough to hit dynamic weekly quotas. (~5 hours/week)
- Be available for staff meetings.
- Being available and active on Skype is a plus.
If you are interested, please fill up the application form and contact Shikisaurus:
- What is your name, and how old are you?
- Tell us something about yourself.
- Why do you want to join this division?
- How long have you been a member of ggFTW, and how have you contributed to the site and the community?
- What is your timezone and usual online times?
You may be required to interview for this position; interviews will be conducted over an instant messaging platform of your choice.
Deadline of Submission: 12 March 2011


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You have searched for: Kagad Kach Patra Kashtakari Panchayat
- Akshaya Patra comes up with new app
The Akshaya Patra Foundation has come up with a new app, named after the organization, which will enable users to identify all schools benefitting under the foundation's midday meal scheme.
- Akshaya Patra Foundation comes up with Akshaya Patra app to help volunteers reach needy children
Bengaluru: The Akshaya Patra Foundation which runs the world's largest mid-day meal program has come up with Akshaya Patra app which will give the power of staying connected with the foundation to all, tracking all its important news and events. The volunteers can now use this app for making donations from mobile phones and create their personalised virtual fund raising campaigns to reach out to the less privileged children in government schools. The application, which already has about 500 users at its initial stage, is a virtual compendium that provides insight about the foundation's efforts to reach out to undeserved children in India with the promise of a wholesome meal, every school day. It allows the users to search all kitchen locations across India, exhibiting the total number of beneficiary schools that are being catered to by these kitchens in a particular area. Since 2000, the organisation has worked towards reaching more children with a day's complete meal in school and is continuously leveraging technology to cater to millions of children. Its state-of-the-art kitchens have become a subject of study and attract curious visitors from around the world. The app was launched in the city by Sudha Murthy, chairperson of Infosys Foundation and TV Mohandas Pai, chairman of Manipal Global Education at Vivanta by Taj on Friday.
- Akshaya Patra conferred with Nikkei Asia Prize
Bengaluru: The Akshaya Patra Foundation has been conferred with the Nikkei Asia Prize for its contributions to the fields of economic and business innovation. Madhu Pandit Dasa, Chairman, Akshaya Patra Foundation received the award on Sunday along with three million JYN and a certificate by Naotoshi Okada, President, CEO, Nikkei Inc. in Tokyo. "I accept this honour with a profound sense of gratitude to Nikkei Inc and with humility on behalf of our movement and for the benefit of those 1.5 million children whose lives have changed because of a wholesome meal day after day," said Dasa. He added, "I would like to share this award with all my mentors, advisors, trustees, donors and friends and over 6000 staff members of the foundation who have given Akshaya Patra their valuable time, wisdom and support." Stressing that by instilling compassion in the hearts of the rich, the basic needs of the deprived can be met, Dasa said, "It is only by promoting and awakening this virtue of compassion, and turning into action in human society, that we can make this world more inclusive, equitable and sustainable." Recognizing achievements that contribute to sustainable development and for a better future of Asia, the Nikkei Asia Prize has been honouring change makers since 1996. One of the largest media corporation in Japan, the award is presented to those who have made significant contributions in one of three areas: Economic and Business Innovation, Science, Technology and Environment and also Culture and Community.
- Akshaya Patra conferred Nikkei Asia Prize 2016
Bengaluru, May 30 () The Akshaya Patra Foundation has been honoured with the Nikkei Asia Prize in Japan for its contributions in the field of "Economic and Business Innovation.
- Bangalore: Understanding Hakku Patra
Bangalore: Understanding Hakku Patra
- Akshaya Patra Foundation wins honour from Japan
The Akshaya Patra Foundation which feeds 1.5 million children every day has been honoured with the Nikkei Asia prize for 2016. The foundation led by former IITian Madhu Pandit Dasa is the winner in the Economic and Business Innovation category.
- Akshaya Patra bags Nikkei Asia prize
BENGALURU: The Akshaya Patra Foundation has been honoured with the Nikkei Asia prizes, to add to its credits. The foundation has emerged as the winner of Economic and Business Innovation. The award was announced on Saturday. The Nikkei Asia Prizes, which are awarded each year, are designed to recognize outstanding achievements that contribute to the region's sustainable development and to the creation of a better future for Asia. Akshaya Patra reaches out to 1,436,596 children in 24 locations across 10 states of India, providing them with freshly cooked meal on all school days. Currently, we implement the mid-day meal programme in 10,872 schools of the country. Nikkei Inc established these awards in 1996 in commemoration of the company's 120th anniversary. The Nikkei Asia Prizes are awarded annually in three areas of achievements. To acknowledge the works of winners (recipients) in today's fast-changing Asia, the titles of the three categories have been changed from this year to: "Economic and Business Innovation," "Science, Technology and Environment" and "Culture and Community." The Nikkei Asia prizes will be awarded on Sunday, May 29 in Tokyo. Winners of the Nikkei Asia Prizes will each be awarded three million yen as well as an award certificate by Naotoshi Okada, president, CEO of Nikkei Inc. Akshaya Patra, as an implementing partner of the Mid-Day Meal Schemeworks with the support of Government of India, the various State Governments and associated organisations. This has enabled the programme to grow from feeding 1,500 children in the year 2000 to 1.4 million children in 2014.
- Akshaya Patra Foundation to feed 35,000 schoolkids in Telangana
BENGALURU: Around 35,000 children of the Ranga Reddy district near Hyderabad, Telangana will soon receive midday meals from the Bengaluru-based Akshaya Patra Foundation. On Wednesday, the Bank of Tokyo-Mitsubishi UFJ, Ltd. (BTMU), an entity of the Mitsubishi UFJ Financial Group (MUFG) agreed to pledge Rs 105.1 million to fund the construction of a new kitchen. Operating towards ensuring midday meals to over 1.5 million children across schools in the country, the foundation has now come a step closer towards its aim of feeding 5 million children by 2020. The bank, an entity of the Mitsubishi UFJ Financial Group (MUFG) has been partnering with community efforts across the country in cities where it is located like Delhi, Mumbai, Bengaluru, Chennai etc. The kitchen that will be able to cater meals to all children of the district is set to be completed by the next academic year (2017-18). The kitchen will be instrumental in providing the meals to all government aided schools, Anganwadis across the district. Not just this, BTMU has also decided to help in delivering and distributing the meals to the schools. "We are pleased to partner with MUFG in constructing this kitchen in Telangana. Such partnerships enable us to continue our work through our initiative to end classroom hunger", said Satya Gaura Chandra Dasa, President, Akshaya Patra, Telangana. The foundation had recently been awarded the Nikkei Asia Prize on May 29 for its contributions made towards development in Asia under the Economic and Business innovation category. With an aim to support the government's initiative to achieve a 100% literacy among school children, Ryoichi Shinke, Regional Executive of BTMU India said, "This is part of our commitment to the community to nurture the next generation. With proper nutrition, we hope the children will be able to enjoy a more conducive learning environment and not having to cope with hunger during school time."
- House in splits over Rout-Patra spat
Cooperation minister Damodar Rout and senior BJD leader Surya Narayan Patro on Wednesday got into a verbal duel in the assembly, exposing the internal infighting within the party.
- Seven more UP districts to be covered for midday meals by Akshay Patra Foundation
AGRA: Akshay Patra Foundation (APF), which feeds nearly 15 lakh government school children (Class I-VIII) daily under the mid-day meal programme at 24 locations across 10 states in the country, including two cities of Uttar Pradesh is all set to extend their kitchen services, in seven other districts of the stare including Prime Minister, Narendra Modi's constituency, Varanasi. According to officials, the services would be functional before November this year in districts of Agra, Allahabad, Jaunpur, Etawa, Kanpur and Kannauj. Confirming this, Anant Veer Das of AFP said they would start in Varanasi and Jaunpur before November this year and remaining districts would be covered subsequently. He said, "our mission is to provide nutritious and quality food to all school children". Anant said the government provides 100 gm of raw material (wheat and rice) per primary student and 150 gm for upper primary students, besides Rs 3.67 and Rs 5 as cooking charges respectively. He said this covers only 50 per cent of their cost and the Foundation depends on donations from corporate houses and individual donors for funds to meet their total expenses. He said their kitchen in Lucknow prepares 60,000 rotis, 10,000 litres milk and 7 tonnes of cooked rice in two hours and serves 74,000 school children in 758 schools. The foundation plans to increase its capacity to cover 1 lakh children in the near future, he said.
- LeEco extends support to Akshaya Patra Foundation for midday meal
LeEco took its first philanthropic step by making a significant contribution towards the nutritional support of children by providing mid-day meals as a basic necessity that helps them in their schooling.
- Japanese firm pledges 105.1 m for Akshaya Patra's midday meal scheme
The Bank of Tokyo-Mitsubishi UFJ (BTMU) on Wednesday pledged Rs 105.1 million to fund the construction of Akshaya Patra's new kitchen that will feed 35,000 children in Ranga Reddy district, Telangana.
- Athiyannur declared ODF panchayat
Athiyannur panchayat has become the first grama panchayat in the district to be declared open defecation-free (ODF).The panchayat accomplished the task by ensuring toilets for all the families.
- Missing 1984 SIT file leaves me shocked and disgusted: Sambit Patra
BJP leader Sambit Patra accused Delhi chief minister Arvind Kejriwal of playing politics on the issue of the 1984 anti-Sikh riots. He added that it was absolutely shocking to hear that a file related to the formation of a Special Investigation Team has gone missing for the last ten months.
- MTR partners with Akshaya Patra to launch midday meals
Bengaluru-based MTR Foods Pvt Ltd has partnered with Akshaya Patra Foundation to provide midday meals to more than 2,000 children from 20 schools in Surathkal for one year.


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Innovative technologies and designs make bizjets more comfortable and functional than ever before.
Business Jet Traveler
May 4, 2015
April 27, 2015
A spectacular world's fair will begin a six-month run in Milan, Italy on May 1.
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Palermo's Hippest Restaurant
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Feeling cramped in your large-cabin bizjet? Maybe you need one of these.
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Governmental agencies demand that aircraft owners maintain voluminous, detailed records. Specialized software can help.
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The task of buying a yacht is much like assembling a jigsaw puzzle: all the pieces must fit together perfectly. Here's help.
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Most of the time, it's smart to get a job done sooner rather than later. When it comes to paying taxes, though, the opposite is often true: putting the taxman off as long as the law allows can be a powerful tool in building wealth, assuming the cost of deferring isn't too steep.
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It's no wonder that Embraer has delivered more than 300 of its Phenom 100 entry-level jets since 2009. Fast and spacious for its class–with a top speed of 390 knots and now room for up to eight occupants–the aircraft resonates with smaller companies charter companies and individual owners.
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Manufacturers are offering to help you sell your old airplane when you purchase a new one. Should you let them?
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Elvis Presley's airplanes, the Lisa Marie and Hound Dog II, are for sale and are expected to go for $10 to $15 million.
""My model for business is the Beatles. They were four guys who kept each other's kind of negative tendencies in check. They balanced each other, and the total was greater than the sum of the parts. That's how I see business: great things in business are never done by one person, they're done by a team." "
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In This Section
Journal Forum
A Meta-Analysis of High Resolution Audio Perceptual Evaluation - June 2016
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Sound Board: High-Resolution Audio - October 2015
4 comments
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Realizing the Optimum Peformance from a Class D Amplifier Controller IC with Feedback and Feed-Forward Techniques
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assistant professor jobs
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Clinical Assistant or Clinical Associate Professor Undergraduate Psych and
University of South Carolina College of Nursing - Columbia, SC
The College of Nursing, University of South Carolina, is seeking a qualified candidate eligible for the rank of Clinical Assistant or Clinical Associate...
Several Assistant, Associate, and/or Full Professor positions
University of Pennsylvania - Philadelphia, PA
We are seeking candidates for several Assistant, Associate, and/or Full Professor position in the tenure track....
Assistant Professor - Visiting
Cleveland State University - Cleveland, OH
CSU is searching for active, culturally and academically diverse faculty of the highest caliber for a non-tenure track instructor position in the Department
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University of Maryland Medical Center Department of Medicine - Baltimore, MD
The faculty appointment will be at the rank of Assistant or Associate Professor, non-tenure track, commensurate with experience and based on guidelines for...
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University of Illinois at Chicago - Chicago, IL
Research Assistant Professor will be responsible for. The University of Illinois at Chicago Department of Surgery is seeking a full time Research Assistant...
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University of Maryland School of Medicine - Baltimore, MD
The Endocrinology, Diabetes & Nutrition Division at the University of Maryland School of Medicine are recruiting for a full time faculty member to work in the
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HonorHealth - Scottsdale, AZ
An academic clinical appointment at the level of Assistant, Associate or Professor is available through the College of Medicine, Phoenix campus, University of...
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Texas Scottish Rite Hospital for Children - Dallas, TX
Seeking assistant professor level scientist with expertise in bone biology or mesenchymal stem cell biology. The candidate will work with an orthopedic team on...
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Professor of Nursing for the School's online Nursing programs:. FACULTY VACANCY ANNOUNCEMENT....
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Assistant, Associate or Full Clinical Professor - Pediatric Dermatologists. Appointment will be at the Assistant, Associate or Full Professor level in the HS...


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Reader Contributions Are Encouraged So We...
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Domainex will receive more than £1.5 million ($2.5 million) in fees over two years to perform lead optimization in an asthma program being undertaken by St George's University of London. The focus is on developing a new treatment based on the inhibition of Der p1, an enzyme involved in triggering asthma attacks.
The research will be spearheaded by St George's University of London and the University of Manchester, which have received a £4 million ($6.6 million) grant from the Wellcome Trust's Seeding Drug Discovery Initiative.
Collaborating scientists at St George's, the University of Manchester, and Domainex have already discovered drug-like compounds that inhibit Der p1. Domainex will now use its virtual screening technology, LeadBuilder, to select suitable leads, and provide St George's with medicinal chemistry support to develop a clinical candidate.
¨¨¨Related NewsAradigm and CyDex Combine Expertise to Tackle Asthma and COPD (Sep. 6, 2007)Novartis Inks Pact with Adenosine Therapeutics to Develop Drugs for Diabetes and Asthma (June 18, 2007)Idera Extends Asthma and Allergy Collaboration with Novartis (Mar. 6, 2007)JHU Selects Illumina Technology to Study Asthma in African-America Population (Nov. 15, 2006)
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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Cash crunch affects match-making programme and mass weddings in Kano, Nigeria
'The matchmaking programme began in 2012 to help divorcées remarry in Kano state, which has the highest divorce rate in Nigeria.'
'The matchmaking programme began in 2012 to help divorcées remarry in Kano state, which has the highest divorce rate in Nigeria.'
Children of well-placed families are landing plum posts amid Muhammadu Buhari's war on corruption.
The Avengers are not superheroes, but rather militants left in the cold by Nigeria's amnesty programme.
Economic woes and new calls for Biafran independence may signal the start of trouble in the country.
'Sixty-one critically malnourished people were among 478 children, 196 women and 23 men brought to the state capital Maiduguri from Bama on Monday'
The West is riding on the hope that the Nigerian leader will defeat Boko Haram and end corruption.
President Buhari's initial announcement to wind down an earlier amnesty deal by 2018 is said to have contributed to the re-emergence of militancy.
The ties that bind Africans to their land need markets, credit and exposure to new practices so that young people can stay on their farms.
President Buhari's anti-corruption plans have gone down a treat, but is there too much on his plate?
The residents of a Nigerian village had no health services, save for traditional methods, to treat those with a fever and a rash.
Local doctor Obiagwu Hillary will never forget the 19-year-old who died after an abortion performed with the spoke of a bicycle wheel.
People in rural Nigeria are afraid of being isolated due to their HIV status and don't access treatment.
Children labelled as witches in Nigeria are often abandoned, shunned by society and turfed out into the streets.
Joshua Olufemi, Emmanuel Mayah
The Panama Papers have blown open evidence that Nigerian tycoon Aliko Dangote is tied to mysterious firms in tax havens around the globe.
Two years after the abduction of the 276 Chibok girls, Human Rights Watch looks at Boko Haram's devastating impact on education in northeast Nigeria.
Lagos start-up Comic Republic is creating African characters with a moral spine - and has made its comic books available for free download.
Financial risk-protection mechanisms could alleviate the high food and transport costs incurred by rural people seeking to access treatment for HIV.
President Jacob Zuma aims to repair rifts in SA's relationship with the West African giant during his visit with counterpart Muhammadu Buhari.
The African terror group has been weakened, but it's now wreaking a new kind of havoc.


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Allergy Shots Topic Guide
Allergy Shots: Allergy shots, or immunotherapy, is recommended for severe allergy sufferers. Typically, immunotherapy consists of a three- to five-year course of allergy shots with the goal of reducing the allergy sufferers reaction to allergens and to reduce or eliminate the person's need for other allergy medications.
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Ambiguity Models and the Machina Paradoxes
Machina (2009) introduced two examples that falsify Choquet expected utility, presently one of the most popular models of ambiguity. This article shows that Machina's examples falsify not only the model mentioned, but also four other popular models for ambiguity of the literature, namely maxmin expected utility, variational preferences, α-maxmin, and the smooth model of ambiguity aversion. Thus, Machina's examples pose a challenge to most of the present field of ambiguity. Finally, the paper discusses how an alternative representation of ambiguity-averse preferences works to accommodate the Machina paradoxes and what drives the results. (JEL D81)
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Volume (Year): 101 (2011)
Issue (Month): 4 (June)
Pages: 1547-60
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- Peter Wakker & Daniel Deneffe, 1996. "Eliciting von Neumann-Morgenstern Utilities When Probabilities Are Distorted or Unknown," Management Science, INFORMS, vol. 42(8), pages 1131-1150, August.
- Fabio Maccheroni & Massimo Marinacci & Aldo Rustichini, 2004.
"Ambiguity Aversion, Robustness, and the Variational Representation of Preferences,"
Carlo Alberto Notebooks
12, Collegio Carlo Alberto, revised 2006.
- Fabio Maccheroni & Massimo Marinacci & Aldo Rustichini, 2006. "Ambiguity Aversion, Robustness, and the Variational Representation of Preferences," Econometrica, Econometric Society, vol. 74(6), pages 1447-1498, November.
- L'Haridon, Olivier & Placido, Lætitia, 2008.
"Betting on Machina's reflection example: an experiment on ambiguity,"
Les Cahiers de Recherche
909, HEC Paris.
- Olivier L'Haridon & Lætitia Placido, 2010. "Betting on Machina's reflection example: an experiment on ambiguity," Theory and Decision, Springer, vol. 69(3), pages 375-393, September.
- Schmeidler, David, 1989.
"Subjective Probability and Expected Utility without Additivity,"
Econometric Society, vol. 57(3), pages 571-87, May.
- David Schmeidler, 1989. "Subjective Probability and Expected Utility without Additivity," Levine's Working Paper Archive 7662, David K. Levine.
- Nicolas Treich, 2008.
"The Value of a Statistical Life under Ambiguity Aversion,"
CESifo Working Paper Series
2291, CESifo Group Munich.
- Treich, Nicolas, 2010. "The value of a statistical life under ambiguity aversion," Journal of Environmental Economics and Management, Elsevier, vol. 59(1), pages 15-26, January.
- TREICH Nicolas, 2008. "The value of a Statistical Life under Ambiguity Aversion," LERNA Working Papers 08.05.249, LERNA, University of Toulouse.
- Daniel Ellsberg, 1961. "Risk, Ambiguity, and the Savage Axioms," The Quarterly Journal of Economics, Oxford University Press, vol. 75(4), pages 643-669.
- Rothschild, Michael & Stiglitz, Joseph E., 1970. "Increasing risk: I. A definition," Journal of Economic Theory, Elsevier, vol. 2(3), pages 225-243, September.
- Itzhak Gilboa & David Schmeidler, 1989.
"Maxmin Expected Utility with Non-Unique Prior,"
hal-00753237, HAL.
- Gilboa, Itzhak & Schmeidler, David, 1989. "Maxmin expected utility with non-unique prior," Journal of Mathematical Economics, Elsevier, vol. 18(2), pages 141-153, April.
- Lars Peter Hansen, 2007. "Beliefs, Doubts and Learning: Valuing Economic Risk," NBER Working Papers 12948, National Bureau of Economic Research, Inc.
- Alain Chateauneuf & Rose Anne Dana & Jean-Marc Tallon, 2002.
"Diversification, convex preferences and non-empty core in the Choquet expected utility model,"
Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers)
halshs-00174770, HAL.
- Jean-Marc Tallon & Alain Chateauneuf, 2002. "Diversification, convex preferences and non-empty core in the Choquet expected utility model," Economic Theory, Springer;Society for the Advancement of Economic Theory (SAET), vol. 19(3), pages 509-523.
- Lars Peter Hansen, 2007. "Beliefs, Doubts and Learning: Valuing Macroeconomic Risk," American Economic Review, American Economic Association, vol. 97(2), pages 1-30, May.
- Marciano Siniscalchi, 2009.
"Vector Expected Utility and Attitudes Toward Variation,"
Econometric Society, vol. 77(3), pages 801-855, 05.
- Marciano Siniscalchi, 2007. "Vector Expected Utility and Attitudes toward Variation," Discussion Papers 1455, Northwestern University, Center for Mathematical Studies in Economics and Management Science.
- Epstein, Larry G & Wang, Tan, 1994. "Intertemporal Asset Pricing Under Knightian Uncertainty," Econometrica, Econometric Society, vol. 62(2), pages 283-322, March.
- Peter Klibanoff, 2001. "Stochastically independent randomization and uncertainty aversion," Economic Theory, Springer;Society for the Advancement of Economic Theory (SAET), vol. 18(3), pages 605-620.
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Pelo, your daily cries that Metabolix is falling flat look a bit desperate. I hope that you didn't short too much when the price dropped below $1.30 last year; it appears as if you are now desperately trying to break even. Metabolix is a company that already fell and is trying to get backup. While you're spending every day here trying to talk investors into running; employees at Metabolix trying to generate value for shareholders. The reason investors aren't fleeing like you is because they see potential, potential in the products, the patents, the licenses and the technology.
An investment right now in Metabolix is very similar to a venture capitalist's investment in any start-up. There is plenty of potential indicating the possibility of a 10x to 30x return but there is also the risk that the company won't succeed. The shareholders who are sticking around are here because they know the story well and they believe that Metabolix will succeed. They may be right!
Regarding "the story"… You like to make out that the whole ADM relationship was a complete flop and ADM gave the finger to Metabolix. Actually the split was a very friendly split. ADM received full ownership of the $400Mil factory that ADM built then they quickly turned it around and started leasing it. Metabolix received a bundle of cash from ADM; which they are using to start anew. It's not as ugly as you make it out to be. The big ugly there was that ADM built a much bigger factory than they needed for Mirel and couldn't fully utilize it without finding a different product.
Sentiment: Strong Buy
Is there going to be a 30,000 automatic sale tomorrow by Muller Edward M, same as Jun 7-8 last year? Any other insiders have automatic insider planned sales coming up?
Any insiders ready to buy down here?
Show us da money!
There was a 10k block dumped at the bid. Large bidders being dumped on during the specialty chem pop today. Gobble Gobble, head choppers lie in wait.
shortareee has some deficiencies but that okay...
The more shorts we have the bigger the squeeze once this company has some real news to announce.
How may days to cover right now?
Is it still over 50 ?
This could hit $3 and beyond overnight if / when the right new is announced.
Sentiment: Strong Buy
I am hoping no further accounting deficiencies are exposed. They manage to burn through $3M/month like clockwork, but claim to have enough cash for continued operations though the end of the fiscal year. They really need a name and ticker change at this point.
The shorts want to trivialize everything you said but you are right
Sentiment: Strong Buy
Why would FMR LLC, their largest institutional investor, .... also located in Boston. Dump 15% of their total holdings. The Period of Report 2013-03-31 - Filing Date 2013-05-15 !!! I would like to know why ..... Investors have a right to know why?
Some institutions have to sell when the price falls below a certain point.
ipelosi, you may not consider insiders bright but they do know a lot more than you about the direction this company is headed.
Considering the fact that several purchased shares, and none are selling, IMHO it appears that they have a strong belief that the share price is destined to go much higher. Only time will tell if they are right.
BTW, I suspect that the insiders have one big advantage over you and your negative perspective; they probably know the value of their portfolio of patents and licenses. I'd venture to guess that its worth pretty close to the current market cap. They have enough cash to give-it-a-go for twelve more months but if that fails then you can bet that they'll look into selling their company for its IP... The sum of the parts may be worth much more than the sum of the whole.
Only one reason for insiders to buy shares, and many reasons to hold
Wow. I never looked at it from the perspective. I'm all in again. THANK YOU for opening my eyes. Up, up and away. Here we go all the way to $100.
Sentiment: Strong Buy
Smart Money has been pulling out, or insiders have been dumping.
It sounds real good and I am also sold but we are a small sliver of the pie
and we might as well be playing roulette in Vegas if were planning on returns
with stock investments. This is a long bet and a long wait to come...


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5 Reviews
Pat, your recipe is an authentic delish! It's sooo easy and so beautiful.
I did not have canned apples and I used fresh ones. I simply prepared the recipe as described prior placing the filling I baked the apples about 15 minutes until slightly soft.
I used frozen fillo which was a little dehydrated. I had to brush the sheets with water and then shape them to roses. In any case this was not a big problem and the roses came out very cute and impressive.
Thanks a lot for this recipe, it's a real winner and I will do it again!
O.k..... I was not too sure about this recipe I must admit, it looked easy and great but would the family like it ....another thing???? So her is the verdict...... This is one fantastic apple pie, so easy with such a fantastic flavour and the texture from the pastry just made this a superb dessert! I made nearly as per recipe........ only one thing different I used fresh apples and cooked them a few minutes in the microwave other than that..... everything was the same as the recipe. I did have a problem with my pastry........... It was frozen pastry I bought and when I defrosted and unfolded it it was all torn in the packet. So with improvised rosettes I didn't do too bad........... if I do say so myself! Gorgeous recipe, easy peasy and wonderful flavours, I should never have doubted one of Pat's recipes in the first place! Pat, the family loved this pie..... served with cream it was demolished with ewww's amd ahhh's in an instant! I have left over pastry & even with it being torn...... I will be making again soon.
What a great idea!!!And so little work involved.Mine actually took a little longer,because I used apples rather than the canned variety,which is not available,but it was still fast and so easy to put together. I added a little lemon rind and even though I'm a big fan of apple pie I prefer this one to it.I don't like getting dough on my hands. Thanks for sharing another great recipe.
Wow Pat, what a ripper of a recipe. I made this for lunch today for a dear friend whose tummy can't cope with regular pastry anymore. I added some wild blackberries we had in the freezer and we ate it with custard. I had a 800g can of apples and managed to use all the filo.
What a great idea for a quick and easy dessert! Simple to make, impressive to look at, and delicious. I'm sure any flavor of pie filling would be great with this. Served warm with vanilla ice cream and really enjoyed - thanks for posting the recipe!


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