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Creamy Maple Fudge Frosting / Icing for Cupcakes
Total Time
Prep 5 mins
Cook 10 mins
The flavor reminds me of the Seaside fudge from my childhood! A nice creamy frosting that's great for cakes and cupcakes, but also would do nice for soft cookies.
Ingredients Nutrition
12 12 cupcakes US
- 8 ounces cream cheese, softened to room temperature
- 1⁄4 cup 1% low-fat milk
- 1⁄4 cup maple syrup
- 1 teaspoon vanilla extract
- 4 cups confectioners' sugar (approx)
- Cream the cream cheese, maple syrup, vanilla, and milk together first with an electric mixer.
- Gradually beat in the confectioners sugar until thick and spreadable, approx 3-4 cups. You might have to whisk by hand really hard at the end to beat out any lumps.
- If the frosting is too thick to be spreadable, thin it out with some milk.
- Makes enough to ice about 12-15 cupcakes.


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- Accessories (13)
Dritz® Iron-Off™ Hot Iron Cleaner
Price: $5.95
Removes the residue from iron-on interfacings, patches and fusible webs, fabric deposits, melted synthetics, and starch buildup - while the iron is hot! Safe for all metal and nonstick surfaces. Nontoxic, nonabrasive, nonflammable. 1-oz. tube.
Product Number: WA11632H
Iron Clean Sheets
Price: $3.95
Remove fusibles and sticky residues. Just wipe your hot iron over the cleaning cloth with a paper towel or rag underneath. Fast, easy, no unpleasant smell. Each of the 10 included cleaning cloths is reusable several times. Made in the U.S.A.
Product Number: WA29922H
Dritz® Vue-Thru Pressing Cloths
Price: $6.95
Dritz® Vue-Thru Pressing Cloths are see-through, allowing you see as you press for more effective results. Pkg. of two 100% cotton cloths (13" x 30" each). Fabric U.S.A.
Product Number: W05384H
Dritz® Sleeve Roll
Price: $7.95
Use the sleeve roll to press small curved areas, seams, sleeve darts, zipper closing, etc. The sleeve roll is covered in wool and cotton, and will not lump, or go limp or flat. 10-1/2" x 3" x 2-3/4". Fabric imported.
Product Number: W03483H
Dritz® Pressing Ham
Price: $9.95
Use to press and shape all curved areas including darts and tucks, sleeve caps, hip lines, etc. Covered in wool and cotton, so steam can penetrate fabric. 11" L x 8" W x 4" H. Fabric imported.
Product Number: W03484H
Non-Stick Pressing Sheet - 12" x 18"
Price: $12.95
PTFE-coated fiberglass sheets allow you to iron over embellishments like iron-on transfers, glitter paints, and delicate fabrics. Fusibles, paints, varnishes, and glues just peel off; starch and sizing wash off. Transparent enough for applique p..
Product Number: WA29923H
Non-Stick Pressing Sheet - 18" x 24"
Price: $19.95
PTFE-coated fiberglass sheets allow you to iron over embellishments like iron-on transfers, glitter paints, and delicate fabrics. Fusibles, paints, varnishes, and glues just peel off; starch and sizing wash off. Transparent enough for applique p..
Product Number: WA29924H
Hot Hemmer
Price: $11.95
Measure, mark, and press in one simple step. Great for hems, binding, rounded corners, purse handles, and miter corners. The thin, accurate, heat-resistant ruler can be pressed with dry or steam irons and features a nonslip surface that stays in pla..
Product Number: WA33562H
Iron Safe
Price: $17.95
Protect your iron and fabric by preventing scorch, burn, and shine marks. Fits snugly over the soleplate of an iron; the nonstick surface protects fabrics while adhesives wipe right off. Eliminates the need for a pressing cloth. One size fits most house..
Product Number: WA33563H
Ironing Mat
Price: $13.95
Perfect for ironing over delicate fabrics, prints, or craft projects that require an iron. Allows all the steam to pass through the holes and works as a pressing cloth without leaving shine behind. Reusable with 100% safe heat transfer. One year war..
Product Number: WA32374H
Machine Embroidery Adhesive Spray
Price: $10.15
Bonds fabrics temporarily or permanently for machine and hand quilting. Great for temporarily bonding fabric, patterns appliqués, and templates. Has a nonpermanent bond (when applied to one surface) and is repositionable. Once sprayed, fabr..
Product Number: WA32642H
Fabric Stabilizer
Price: $10.25
Use this spray to hold fabric firm while working. Ideal for machine embroidery, lace making, Battenberg, heirloom sewing, and appliqué. Will prevent fabric from fraying until washed out. Firms tricot to apply lace, etc. Holds voile chiffon, and sof..
Product Number: WA32643H
Quilt Basting Spray
Price: $10.25
Save hours of frustration by eliminating tedious hand basting and pinning. Can be used for both machine and hand quilting. This spray temporarily bonds fabric to batting (poly or cotton), patterns, templates, or appliqués to fabric, etc. Th..
Product Number: WA32644H
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subset: commoncrawl


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The Schaumburg Dining Out Meetup Group Message Board › Attn SDO: 6 spots remain for the Mardi Gras Party tomorrow at Pappadeaux in
River Grove, IL
Hello SDO,
I added 10 spots to this party.
Right now, 6 spots remain for our annual Mardi Gras Dinner Party at Pappadeaux! 54 people already paid and confirmed!
Enjoy a full seafood buffet dinner with our famous "musical chairs" format where you will move from table to table during different stages of the dinner.
We will have a live band for about an hour playing just for us!
All of this in our own private private party room decorated like the New Orleans (who dat?) French Quarter with our own separate bar area where we can mingle.
Plenty of masks and beads on hand. Feel free to dress up for the party. A prize will go to the person with the best costume!
Info and RSVP at:
See you there!
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
Label: Lost In Da Ghetto Life
Manager: The Godfather
Bio: Alkoori aka Alcapino Da Don Is Born in Africa - Tanzania In Dar Al Salam, 1987 October 10. Hes Father was A Soldier For the P.L.O Army and hes mother left the family when he was 3years old. he begin rhymes and lyrics sense he was little young boy 11-12years. He fall in criminal with hes homeboys ...See Full Bio


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by Carl Scott ~ Paperback
A guide to preparing food using a process which has its origins in the days when preservation of food was not as simple as just throwing it in the fridge. Smoking ensured that foods would last until the next hunting season. By using salt to draw out moisture over a period of days, or even weeks, the...
Usually ships within 3-5 days
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Add some variety to your fitness routine with these upper and lower leg exercises from The American Council on Exercise. We have a large selection of leg exercises that will will help you strengthen and build muscle throughout your legs including your hamstrings, thighs, shin and calf muscles. Start taking advantage of this free information today! If you are looking for full workout routines that incorporate these leg exercises, check out our Workouts section.
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Maintaining a healthy weight can be challenging and, for some people, even more difficult than losing weight. The good news is that achieving lasting weight maintenance is possible. Use these 13 tips to help you succeed at maintaining your weight-loss goals.
Chances are you've heard of a familiar-sounding game that took the social media world by storm recently. Pokémon has returned—new and improved with a little twist.
Over the past decade, the number of people biking to work has increased by 60%. More cities across America are embracing bike-friendly policies and programs, making it safer for people to integrate cycling into their modes of transportation. Biking to work can be...


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Modernizing antique radios Antique radios are nearly as common as antique malls. The key is to familiarize yourself with items to look for. Naturally, some units are more ornate than others, but it...
Vintage radios are fun, classy, and add a touch of nostalgia to any decor. Whether purchased for the sound or look, they definitely add a unique element to both. Many are very inexpensive, working or not,...
When people talk about vintage radios,, they tend to have in mind one of several rather different kinds of radio equipment. They may be thinking about the cathedral - style home radios that provided a...


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A Scrap of Beethoven Better Left Unheard?
By ANTHONY TOMMASINI
Published: September 16, 2001
One dismaying sign that the classical-music field remains stuck in place is the hoopla stirred up every time some musicology sleuth claims to have recovered some work by a past master. Apparently, any scrap of music, however sketchy, by a great dead composer is bigger news than a new work by a worthy living composer.
The latest instance concerns an overture by Beethoven for an opera project based on Shakespeare's "Macbeth." The supposed Beethoven piece is not a piece at all but an eight- minute realization of some Beethoven sketches by Albert Willem Holsbergen, a composer and computer programmer from the Netherlands.
This realization is about to get a fancy send-off. Last month, in a hyperbolic press release, the public relations department of the National Symphony Orchestra announced that Leonard Slatkin, the orchestra's music director, would conduct the "world premiere of Beethoven's Overture to `Macbeth' " in the orchestra's season-opening concert on Thursday at the Kennedy Center in Washington.
A full reading of the release revealed some qualification of the big news. The performance was referred to more precisely as "the world premiere of a new performing version of Beethoven's sketches for `Macbeth.' " But such quibbling did not deter the excitable Mr. Slatkin, who was quoted as saying that "the opportunity to give the world premiere of a Beethoven composition — even a small portion of it — is astonishing." He added, "All of us at the National Symphony Orchestra are honored to participate in this event."
The same went for the folks at the Ira F. Brilliant Center for Beethoven Studies in San Jose, Calif. "This is the first premiere of a Beethoven orchestral work to take place in this hemisphere," James F. Green, a trustee at the center, was quoted as saying. "The Beethoven Center is overwhelmed to be part of this occasion."
So what exactly is this reconstruction job? How did it, and this well-hyped premiere, come to be?
That Beethoven sketched some ideas for an opera on "Macbeth" to be written with the librettist Heinrich Joachim von Collin is not in dispute. It was one of several subjects for operas that Beethoven considered and abandoned, including "The Return of Ulysses," "The Ruins of Babylon," "Romulus and Remus" and "Bacchus." After Beethoven's death in 1827, the sketches for "Macbeth," which apparently don't amount to much, wound up in three separate locations in Bonn, Berlin and London.
In the spring of 1997, Mr. Holsbergen and Mark Zimmer, an attorney and Beethoven enthusiast in Madison, Wis., met on the Internet through a Beethoven chat room. They began exchanging tapes of rare recordings of little-known Beethoven works, including computer- synthesized performances of unperformed works, and eventually created a new Web site, Unheard Beethoven (www.unheardbeethoven.org).
Mr. Holsbergen posted the "Macbeth" sketches on the site. They amounted to just under a minute of music. Things really got cooking, however, when a visitor to the site urged Mr. Holsbergen to examine the sketches for the Largo movement of Beethoven's Piano Trio in D (Op. 70, No. 1), the "Ghost," asserting that some scholars have noted a similarity between the sketches for it and the overture.
It is very possible that Beethoven recycled music from the abandoned overture in the later chamber work. This is all speculative at best. But emboldened by the suggestion, and fortified by some scanty notes Beethoven wrote, in which he apparently described the scope and character of the intended overture, Mr. Holsbergen conflated the one minute of "Macbeth" sketches and the sketches for the Largo, padded, no doubt, with his own filler, into the eight-minute work that Mr. Slatkin will conduct.
Mr. Green, from the Beethoven center, which obviously wants to keep Beethoven newsworthy, embraced the project. Looking for someone to conduct the work, he went to the right guy, for Mr. Slatkin has made novelty in programming his calling card.
But this performance raises larger questions than whether the work has any authenticity. Even if the sketches were more extensive than they are, should they be pumped up into a concert work? Perhaps more than any other composer, Beethoven would be disconcerted to have his sketches taken in any way as finished works, because he struggled so hard, and so ingeniously, with the matter of musical structure.
If you were making a case for Beethoven as the greatest composer in history, you would base your argument on his uncanny ability to bring organic cohesion and structure to music. Beethoven took little motivic ideas, often just odd, blunt rhythmic and melodic gestures, or cells of pitches, and from these materials built entire movements, whole sonatas and symphonies, in which every passage, every episode, was derived from the initial materials. Haydn, Beethoven's teacher and mentor, was also a master of this process, sometimes called thematic development. Haydn was better at this than Mozart, who was ideally suited to opera. Whenever Mozart confessed to working really hard at a particular composition, it was always a piece that involved thematic development. "Le Nozze di Figaro" just flowed out of him. But he really sweated over the six string quartets he dedicated to Haydn.


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Anna's Magnificent Meatballs
Total Time
Prep 15 mins
Cook 25 mins
These meatballs always turn out to be delicious! The oatmeal is a trick that helps them to stay moist and not become dry, and they have a really nice flavor. You can always use fresh onion instead of the onion powder. Don't want to make meatballs? You can also use this meat mixture to make meat loaf- just form it into a loaf shape instead.
Ingredients Nutrition
8-12 3 doz. meatballs US
- 2 lbs ground beef
- 1 -2 egg
- 1⁄4 cup breadcrumbs (optional)
- 1⁄2 cup quick oats
- 1 1⁄2 tablespoons adobo seasoning
- 1 1⁄2 tablespoons garlic powder
- 1 1⁄2 tablespoons mccormick Montreal chicken seasoning (optional)
- salt (to taste)
- pepper (to taste)
- 1 1⁄2 tablespoons onion powder
- 1 1⁄2 tablespoons italian seasoning (optional)
- 1⁄4 cup parmesan cheese (optional)
- Preheat oven to 400°F.
- Combine meat with seasonings, eggs, oats, bread crumbs, and cheese. Roll meat mixture into the sized meat balls you desire. Place on a foil lined cookie sheet and bake for about 20-25 min., or until meatballs are browned and cooked through.


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A rainbow of brilliantly colored gems makes this tiara magical. Stained glass tiara is imported.
A long, flowing wig of deep red makes poison ivy look extra dangerous! Imported.
A soft, shiny pair of leggings for your wee glitterbird. Cotton-rayon. Machine wash. Made in USA.
A delicate accessory for a graceful little lady. Made of paper and wood. Imported.
Take your black cat out for Halloween. You'll find out who's superstitious and who isn't! The plush cat is 7" and the bendable leash is 28". Polyester. Pet cat on a leash is imported.
Turquoise and white feathers on this magnificent headdress stand tall and drape down your back. Imported.
Your princess wears an elaborate headpiece covered with plumeria and raffia. You can almost smell the scent! Imported.
Faceted crystals create a glistening tiara. It nestles in your hair with the help of two attached bobby pins, making a magical finish to your costume. Imported.
What's Rapunzel without her beautiful long tresses? The size 2/6 wig is 40" long, size 8/12 is 54" long. Imported.
Rapunzel tops her long tresses with this beautiful hennin to match her dress. It's fashioned of blue brocade and flowing tulle. Polyester-nylon. Imported.
Cora always looks stylish when out and about, which means a hat is a must. This beauty is topped with feathers, a bow and flower. Imported. Downton™ and Downton Abbey®. ©2014 Carnival Film & Television Limited. All Rights Reserved
Cover your daisy "stems" with cute capri-length leggings that match your costume. Polyester, polyester-spandex. Imported.


text: News Claremont park receives 'green' accolades April 05, 2013 9:10 AM Claremont parks and recreation staff and their years of work into the restoration of Sycamore Canyon Park are not going unnoticed. The California Parks and Recreation Society District 13 recently acknowledged the city of Claremont with a Going Green Award for its endeavors with the restoration project. The prize honors excellence in planning and design when it comes to facilities and parks that promote recreation and protect environmental resources. The journey to rebuilding Sycamore Canyon has been years in the making, a daunting task after the 2003 Grand Prix Fire left much of the area ravaged and overrun with debris. Entire Story Documentary film shows hard realities of slave trade April 05, 2013 8:43 AM The first step in making a difference is making some noise, and Fair Trade Claremont and Traffick Free Pomona don't plan on keeping quiet. The 2 social justice groups are joining forces once again on Tuesday, April 9 to host a free screening of Not My Life, a documentary focused on the global reach of today's continued slave trade. Filling up the seats of the Laemmle Theatre is the initial step in their battle towards a slave-free world. "Raising awareness is the first step to eradicating human trafficking," said Tamiko Chacon, pastor of social justice at Pomona First Baptist. Entire Story Claremont's Earth Day is on the way April 04, 2013 10:34 AM Preparations are underway for the city of Claremont's annual Earth Day celebration, to be held this year on Saturday, April 20 from 10 a.m. to 3 p.m. The event will include live entertainment, workshops, art displays, kids' activities, a bike rodeo and green building tours, including the Uncommon Good Whole Earth Building and buildings at the Claremont Colleges. Entire Story Collaboration on preparedness drill April 03, 2013 4:48 PM Preparedness was the order of the day on Tuesday when members of the local Community Emergency Response Team (CERT) conducted a training exercise at the site of the old La Puerta Junior High School. CERT trainer Dennis Smith said he picked the spot, which was closed as a middle school in 1978 and continued to be used for a number of subsequent years for adult school classes, because he "knew it would be kind of in a shambles." Here was the scenario being enacted: A large earthquake has rattled the Los Angeles area. See our story and special photo gallery. COURIER photo/Steven Felschundneff Entire Story | Photo Gallery Claremont set to 'Rock the Fourth' April 03, 2013 8:30 AM Elaine Ulmer, a second grade student at Chaparral Elementary School, was selected as the winner of this year's Fourth of July Celebration Theme Contest. According to Elaine's wishes, "Claremont Rocks the Fourth" this star-studded Independence Day. Entire Story New York Times Bestseller comes to Claremont April 02, 2013 10:58 AM Award-winning author Rebecca Skloot will speak at Claremont McKenna College's Athenaeum tomorrow, Wednesday April 3, at 6:45 p.m. The talk is free and seats are open to the public on a first-come, first-serve basis. Ms. Skloot is known for her New York Times Bestseller The Immortal Life of Henrietta Lacks (2010), which the Friends of the Claremont Library's chose as the selection for last year's On The Same Page book series. Entire Story Outdoors after hours? Get a ticket April 02, 2013 10:27 AM Claremont Police Corporal Hector Tamayo and Officer Jeff Ting cite a cyclist for being in the Claremont Hills Wilderness Park after hours on Friday. Police are stepping up enforcement of the hours as part of the park's overall changes, including the new parking lot and no parking zones. Over the last couple of weeks, police have issued close to 150 tickets, which are $50 each, to park visitors who stay past the posted hours. Check out our complete story. COURIER photo/Steven Felschundneff Entire Story Resident cooks up trouble in Claremont home April 01, 2013 1:26 PM The Claremont Police Department continues to investigate a lab experiment gone wrong in north Claremont Friday evening. Claremont dispatchers received an emergency call around 6:30 p.m. A witness claimed to have heard an explosion and scream for help in the 1900 block of Judson Court. Officers arrived on scene to find a man suffering from burns to his body after a chemical experiment blew up in his face, according to Claremont Lieutenant Mike Ciszek. The man was allegedly in the process of turning marijuana into hash oil, Lt. Ciszek confirmed. Entire Story And they're off... March 30, 2013 12:01 PM As the announcer counts down to one, children ages 3 to 5, with several parents in tow, scramble to find as many goodies as they can on Saturday during the annual Spring Celebration in Claremont's Memorial Park. It took the youngsters about 30 seconds to grab up all of the eggs but there was plenty of fun to be had at the other festival attractions. COURIER photo/Steven Felschundneff Entire Story | Photo Gallery Community gathers to christen new CHS theater March 29, 2013 10:57 AM School officials and theater supporters cheer after former teacher Don Fruechte cut the red ribbon on the newly renovated Don F. Fruechte Theatre for the Performing Arts on Thursday at Claremont High School. Following months of construction the upgraded performance complex will hold its inaugural show this Saturday with the Alumni Gala Performance at 7:30 p.m. Additionally there will be an open house at 4:00 p.m. so the community can have a look inside the theatre. More in our next edition. COURIER photo/Steven Felschundneff Entire Story Police investigate attempted break-in at local liquor store March 29, 2013 9:55 AM Police are requesting information regarding an attempted early morning break-in at Rocky Liquor, located at 1045 W. Foothill Blvd. in Claremont, on Friday. Officers say the liquor store's burglar alarm was activated around 1:40 a.m. when an unidentified person attempted to open the store's rear door. The subject fled before officers arrived. Police ask anyone with information on this incident to call 399-5411. Entire Story Claremont ready to move money to 'West' March 28, 2013 9:18 PM The council's handling of the tree policy was one of several council decisions appreciated by Claremont residents present at Tuesday's meeting. In addition, the council approved a 5-year contract with Bank of the West. Occupy Claremont members were pleased with the decision after having pushed the city to move its money from Bank of America to a local credit union since early 2012. The city expects to save up to $14,000 annually beginning with the 2013-2014 fiscal year. "How's that for a win-win situation?" said Karl Hilgert. Entire Story Will new lot finally solve Wilderness parking issues? March 28, 2013 9:31 AM The Claremont Hills Wilderness Parl parking lot is now open, but according to weekend visitors, the verdict is still out. The city debuted the newly expanded parking lot last weekend to mixed reviews. For the most part, feedback has been positive from locals and park regulars concerned with overcrowding, according to Eric Flores and Kay Dorn-Giarmoleo, city recreation leaders on hand at the park's entrance to answer the questions of curious hikers last weekend. "Residents around here have been really happy, because there has been such an influx of traffic," Ms. Dorn-Giarmoleo said. Entire Story Council votes to allow arborist to decide on Club pine tree removal March 27, 2013 9:40 AM The Claremont City Council Tuesday night reached an agreement palatable to both sides of a longstanding debate over the Claremont Club neighborhood's pine trees and the city's tree replacement policy. While 44 trees have the potential to go, should a certified arborist deem it necessary, the city will not move forward in changing its tree replacement policies as they stand. For years the city has combated structural damage caused by a series of mature pines in the neighborhood-—including those found on Shenandoah Drive, Davenport, Elmhurst, Gettysburg and Stanislaus Circles. This summer, the city will move forward with a $167,060 project to more extensively repair damaged hardscape. Entire Story ‹ First « Previous106107108109110111112113114115116117118119120121122123124125126Next » Last ›


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A charter fishing boat trolls Tuesday for king salmon in Fritz Cover near the North Douglas boat ramp. Many anglers are targeting the terminal fishing area in Fritz Cove.
Sound off on the important issues at
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"Viva La Comida! puts the spotlight on the ethnic food of the city's most diverse borough – Queens"
"A culinary and entertainment extravaganza!"
"A celebration of amazing food, beautiful culture, and Jackson Heights, a wonderful, vibrant community in Queens."
Viva la Comida! is a festival highlighting the cultural diversity Queens, combining food with music, art, dancing, entertainment and more on a street known for its outpouring of vibrancy.
With local food trucks, an art exhibition, an open market atmosphere, and dancing amid live music from a collection of latin, jazz, and roots bands, this is a pure celebration of what makes 82nd Street the heart of the city.
Have you contributed to the Viva la Comida! fundraiser yet? Please donate! www.gofundme.com/vivalacomida
Invite your friends on Facebook
Follow us on Twitter @82ndStQueens #VivaLaComida2016
LOS ALIENS come from a place where their star radiates perpendicular into their atmosphere creating an environment where hot grooves reproduce like viruses becoming part of their daily sonic landscape. They infiltrated here and are using technology and their infectious rhythms to advance a tolerant planetary culture. They are known to be spontaneous creators on their sound machines to take the minds of their listeners to the vast unknown while they experiment with the power of their beats to make bodies move unconsciously and unceasingly.
Sofia Ribeiro is one of the greatest voices from the country of fado, a magnificent singer who has the ability to immediately attract the listener to her unique musical universe. Well-known for her strong and emotional performances, the multi-awarded singer has captivated audiences all over the world with her charming and powerful sound. Her most recent work blends elements of jazz, Brazilian and Portuguese music.
Martin Vejarano's (Chia's Dance Party, La Cumbiamba NY) new project draws from a festive repertoire of Colombian Cumbia standards. These all-time favorite Cumbia hits will take you back to the golden years of the genre as well as inspire you to dance and contemplate the joy and energy that this Cumbia River brings along. Featuring tuba, accordion, clarinet, percussion and voice, the band delivers a captivating fresh sound.
Gilberto Colón Jr., affectionately known as "PULPO", the esteemed pianist initially received this nickname from his brother and conguero Eddie Montalvo during a live recording session. Soon after, superstar vocalist Héctor Lavoe made the same reference during a show at the legendary Corso Nightclub for his dynamic ability to move up and down the keyboard telling a story through his solo. From then on, the name stuck and he continues to live up to his melodic and spontaneous reputation on the piano.
Dj Funkenstein, Willy Gonzalez, sound craftsman and the soul of the party, brings to us the most danceable rhythms of the whole world. After other multiple appearances at Bembe in Brooklyn, The Colombian Film Festival, The Havana Film Festival in New York and Nublu in the Lower East Side, he comes to Viva la Comida! for the second year to get groovy, hot and tropical! Willy likes to ride on a wave of wide genres, taking the dancers to a variety of places and cultures.
Payaso Carlitos
Bring all the family for a day of fun! Clown show, face painting and a surprise picture character!
Led by local artist Adrian Bermeo. Born and raised in Queens, Adrian Bermeo is known as an abstract artist. Proud of his Latin American heritage, as well as being a native New Yorker, his organic works display his influences in nature, music, graffiti and hip hop culture.
Welcome to #82ndStreet #MamaEmpanada! Grand opening this Friday, 7/29 #Elmhurst #Queens #NYC #Colombian #Food https://t.co/BRdRnrCjkf2 days ago
New light pole banners went up today on #82ndStreet #queens colorful design by local artist John Cebollero! https://t.co/ie7S9t8xnT5 days ago
Grand Opening celebration all weekend @SKECHERSUSA new store 37-12 82nd St #jacksonHeights #queens #sales #giveaways https://t.co/iG23Ey7A875 days ago
The 82nd Street Partnership is an award-winning neighborhood development group founded in 1990 that serves nearly 200 businesses in Jackson Heights and Elmhurst, Queens. Its mission is to improve neighborhood quality of life and support small business growth by creating a more inviting and vibrant commercial corridor.
Funding for the event is provided by private and public sponsors.


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The Town of Nantwich
Nantwich is a small town in England UK, in the county of Cheshire. This area is located in the north western parts of England and are south of the well-known cities of Liverpool and Manchester. Even though the population of the town comes to only about 17 000 people it is a popular parish holding a


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Researchers noted there were about 1.5 cases of intussusception for every 100,000 infants who were given the RotaTeq rotavirus vaccine. In another study, researchers found no increased likelihood of the bowel obstruction with RotaTeq, but did find 5.3 cases of the complication per 100,000 babies who received two doses of the Rotarix vaccine. Both studies were published in the New England Journal of Medicine.
Full Story:WebMD, DailyRx.com


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Hotels near Palazzo Davanzati Museum
Search hotels near Palazzo Davanzati Museum in Florence
Last minute Florence deals
- Villa Il Mosaicofrom $124$87
- Cimatorifrom $99$94
- Hotel Californiafrom $95$47
- Granduomo Charming Accomodationfrom $195$166
- NH Collection Firenze Porta Rossafrom $200$189
Trending now in Florence
- Most bookedHotel Pierre
572 people looked at this hotel in the last hour
Most recent review
"Stayed with my family of four at this hotel which is continently located in the heart of Florence. Although the room was comfortable to fit us all, the actual room was run down and very sparse compared to the elaborate and ornate room in the photos for that specific room type that we booked. I ..."
A Traveller, Jun 2016, CA
469 people looked at this hotel in the last hour
Most recent review
"It was a great hotel I would definitely stay again and recommend to anyone"
A Traveller, Jun 2016, GB
331 people looked at this hotel in the last hour
Most recent review
"Porta Rossa is a beautiful, stately hotel. It has lots of history. Staff was extremely helpful will all questions. Breakfasts were delicious and there was a lot of variety. We were upgraded during our stay which was delightful. Rooms were clean and bathrooms well appointed. They provide terry..."
A Traveller, Jun 2016, US
66 people looked at this hotel in the last hour
Most recent review
"Nice hotel- free breakfast & happy hour; great dinner reservations, very helpful staff; large room; many steps to climb to get into hotel"
A Traveller, Jun 2016, US
62 people looked at this hotel in the last hour
44 people looked at this hotel in the last hour
Most recent review
"It is located on a quiet street just below the Plaza Republica. The rooms are decent and the staff very helpful. The breakfast was more than adequate and real fresh-brewed coffee vs the Nescafé machine. Everything on the Firenze card was within easy walking distance as was the train station. The ..."
A Traveller, May 2016, US
27 people looked at this hotel in the last hour
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Dec 12, 1995
|Filing date
|Nov 15, 1994
|Priority date
|Jul 14, 1987
|Fee status
|Also published as
|Publication number
|Michio Naka
|Original Assignee
|Kabushiki Kaisha Kyoto Daiichi Kagaku
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (13), Non-Patent Citations (2), Referenced by (15), Classifications (11), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a continuation, of application Ser. No. 08/080,395, filed Jun. 21, 1993, now abandoned, which is a continuation of application Ser. No. 07/751,625, filed Aug. 23, 1991, abandoned, which is a continuation of Ser. No. 07/218,742, filed Jul. 13, 1988 abandoned.
The present invention relates to an improved automatic measurement method of glycohemoglobin based on the principle of high pressure liquid chromatography and to an improved sample injection valve used for a high pressure liquid chromatograph.
Glycohemoglobin (HbA1) attaching glucose to hemoglobin is often found in diabetes patients, and particularly HbA1c has been an important measurement item as an index for a health screening such as a medical checkup or for a long-term control of diabetes. Because, HbA1c exists most abundantly in glycohemoglobin (HbA1) and the increase by diabetes is much more than in the other component, and moreover the value of HbA1c shows a significant correlation with an average blood sugar level in hunger for past 1˜3 months.
Glycohemoglobin includes HbA1a and HbA1b besides HbA1c, and these fractions are measured by colorimetry, electrophoresis, minicolumn method, or high pressure liquid chromatography. Among them, in the area of clinical tests, recently high pressure liquid chromatography (HPLC) has been prevalent in view of required time and separation.
A so-called stable type in HbA1c shows a significant correlation with a past blood sugar level and besides a labile type does not so. The rate of the latter is said to be 10˜15% in all HbA1c in hunger on healthy human. In this labile HbA1c, the N end of β-chain of hemoglobin and the reductive end of glucose form a reversible Shiff-base combination, which generates and degrades in a relatively short time depending on blood sugar levels. Therefore, it exists in diabetes patients more than in healthy, sometimes being 10˜20% to all HbA1c. After meal it exists more than in hunger, being effected largely by the condition in collecting blood.
Stable HbA1c is generated from labile HbA1c gradually, continually, and irreversibly, reflecting the past long-term blood sugar levels. Thus, the separate measurement of the stable type only is desirable. However, both of the stable and labile types closely resemble structurally, being considerably difficult to separate by liquid chromatography.
As a method against this, the elevation of separation has been conducted by using a long high-separation column. Though this method has a merit that the denaturalization of glycohemoglobin by chemical treatment may not occur, the analyzing time of ten and several min or more is necessary to gain a good separation, insufficiently dealing with the increase of samples or urgent measurement. Moreover, this type of column is long leading to the apparatus of large type and high cost.
As another method for separately measuring the stable HbA1c, there is a method wherein the labile HbA1c is removed by degrading chemically in pretreatment. This is based on that the temporary combination (Shiff base) of labile HbA1c and glucose is easy to degrade. For instance, washed red cells are incubated in isotonic phosphoric acid buffer solution (37� C., 4 hrs) or in physiological saline solution (room temperature, 14 hrs) to release glucose from labile HbA1c.
Or, there is also a method wherein whole blood added a hemolyzing reagent is incubated at 35� C. for ten and several hrs. It reduces the level of labile HbA1c by hemolyzing and diluting a sample, particularly having a large effect in the acidic area below pH 6, a fast reaction speed, and a large effect at an elevated temperature. Further, the addition of the reagent for removing labile HbA1c containing boric acid on the market which has been used for minicolumn method enlarges the effect.
However, the pretreatment requires time, and together with the degradation of labile HbA1c, the degradation and change of other glycohemoglobin and pure hemoglobin (HbAo) proceed also at the same time.
The hemolyzing type has had a defect that the quantity of stable HbA1c varies with the time elapsed after hemolyzing and the temperature experienced till measurement. Particularly, in the case of the automatic measurement of a number of samples, there has been a disadvantage that the dilution of blood sample by the hemolyzing liquid containing a degrading reagent changes the sample measured later in samples on standby by excessive proceeding of reaction because of longer time elapsed.
The object of the present invention is to provide a method for measuring stable HbA1c with good reproducibility and high accuracy with preventing the degradation and change of glycohemoglobin other than labile HbA1c together with the analysis of glycohemoglobin using the labile HbA1c removing reagent (degradation reagent) by high pressure liquid chromatography. In addition, the object of the invention is to provide a method for analyzing glycohemoglobin wherein the structure of the apparatus is relatively simple and the treatment and preparation of sample are easy.
Further, the object of the invention is to provide a optimum sample injection valve to control the temperature of mixing solution of sample (not limited to blood sample) and reagent in a high pressure liquid chromatograph.
FIG. 1 is a flow diagram showing an example of glycohemoglobin automatic measurement apparatus embodied the invention method. FIG. 2 is a flow diagram showing the sampling part. FIG. 3 is a rough oblique showing the sample injection valve. FIG. 4 is a plan showing the state of the sample injection valve when injecting sample into column.
The object mentioned above is attained by allowing a number of blood samples as whole blood or blood cell layer to stand by, sampling a sample at the time of its measurement order, mixing the sample by quickly diluting with hemolyzing liquid containing a labile HbA1c removing reagent, and by injecting the mixing liquid into a high pressure liquid chromatograph column at a specified time after mixing start. Hereafter, "sample" refers to whole blood sample (or blood cell layer), and "specimen" refers to mixing liquid diluted the sample by hemolyzing liquid.
Further, the reaction is accelerated by warming till the mixing liquid (specimen) is injected into column, enabling the speedier measurement. When this warming is made at the loop part of sample injection valve, preparation of other warming zone or useless warming of specimen is unnecessary, enabling space and energy saving.
Further, the invention saves time of mixing reagent manually, and prevents errors by manual mixing and the change of sample till measurement after mixing.
The procedure of the invention and the structure of the measurement apparatus will be described in the following.
First, blood samples collected from each patient or subject are put into sample vessels such as blood tubes or sampling cups, and allowed to stand by at the sample holding part as whole blood or blood cell layer. Since whole blood or blood cell layer centrifuged whole blood is used, pretreatment is unnecessary and simple. Blood cell layer may be uased by making use of remaining plasma after the other tests, but whole blood also deposits blood cell components at the bottom after standing for long time. Accordingly, sampling is preferably made from the vicinity of the bottom. Though there is a variation in the rate of red cells in blood sample, the rate of HbA1c to HbAo or the other HbA1 is constant in each sample, being no problem. An anticoagulant is usually added to blood sample. As anticoagulants, ones on the market such as heparin or EDTA-2Na may be used.
Each sample vessel is held in a holding device such as rack, snake-chain, or turn-table in a large number, and sent into the sampling position in order.
At the sampling part, a specified quantity 1 to few μl) of sample is suctioned from a sampling nozzle by the suction action of pump, and diluted by hemolyzing liquid containing a labile HbA1c removing reagent separately supplied, and mixed. The dilution is tens˜hundreds-fold, preferably 10˜400-fold.
As the procedure of sampling and dilution, various structures and changes are considered depending on the structures and combinations of various types of pumps. In short, preferable is the structure wherein blood samples sampled within few tens sec˜few min just before measurement are diluted with hemolyzing-washing liquid and injected into column through sample injection valve at a specified time after mixing start. It is necessary that these actions are made automatically and continously and a means is devised to prevent contamination.
As labile HbA1c removing reagents, boric acid, phosphoric compunds, or reagents on the market containing them are used. Ones having acidic pH are preferable. As hemolyzing agents, general ones on the market are used.
As a column, one for high pressure liquid chromatography such as filled with spherical ion-exchange gel (anion, cation) is used, and the treatment time of specimen is confined by the separation.
The state of reaction proceeding after hemolyzing depends upon the property of the labile HbA1c removing reagent, and is associated with the time and temperature after reaction start. The time for measurement is the sum of the operation time for sampling, diluting, mixing, feeding, and washing and the warming time. The short measurement time is preferable to treat a number of samples. If the ability of degrading labile HbA1c of the reagent is low, the shortening of the reaction time is made by warming the specimen (mixed liquid) pass in the temperature range without trouble such as the change of sample. In this case, the temperature of whole or part of the pass including the sample injection valve part is so controlled that the time till measurement is constant in view of the analyzing time and the degradation ability of the reagent. In view of the degradation ability and the warming time, the warming temperature is 30�˜65� C., preferably 40�˜55� C. The temperature above 65� C. causes the change of protein undesirably. That below 30� C. may require cooling in summer.
In the following, the washing liquid will be described. The washing liquid washes the sampling nozzle and each pass to prevent contamination after measuring the late specimen. The structure of the invention, wherein the sample is mixed after dilution by hemolyzing liquid, requires naturally 2 feeding systems of washing and hemolyzing liquid. As a matter of course, this structure may be used, but combining the both as the hemolyzing-washing liquid lessens one of the feeding pumps, simplifying the piping and feeding sequence.
In the invention, the mixing liquid (specimen) is injected into column at a specified time after the mixing start of blood sample and hemolyzing liquid. In case of the mistimed mixing start in calculating back from the next injection timing for some reason such as smoothless shift of rack or mistimed wedging measurement, blank measurement action is preferably made without mixing and injection in this time. This mistimed mixing has no problem in the case of the use of only one type of eluting solution, but in the case of 2 types or more of eluting solution of different concentration or pH, the mistimed injection loses the balance in the column.
The present invention method will be described in detail by showing the following example of the measuring apparatus of glycohemoglobin embodied the invention method. In the example, hemolyzing liquid which also serves as washing liquid is used and a specimen is warmed in the sample-loop at the sample injection valve.
FIG. 1 is a flow-diagram showing an example of glycohemoglobin automatic measuring apparatus embodied the invention method. FIG. 2 is a flow-diagram showing the sampling part. FIG. 3 is a rough oblique showing the sample injection valve.
The apparatus is composed of a sample holding part(1) for holding and pooling plural sample vessels containing whole blood sample or blood cell layer, a sampling part(2) for sampling and diluting-mixing with hemolyzing liquid, a bottle-unit part(3) for receiving vessels for eluting solution, hemolyzing-washing liquid, and waste solution, an analyzing part(4) including a sample injection valve, column, and photometric means, a memory-control part for controlling the whole apparatus function, memorizing and calculating measurement values, and outputting the results on indication apparatus such as printer together with patient number and measuring date, and a keyboard for inputting working command. As the memory-control part, a microcomputer(5) is, for instance, used. For the indication apparatus, a digital indicator may be used besides.
The structure and function of each part will be described in the following. In the sample holding part(1), a number of racks(7) holding plural sample vessels(6) are set. Each rack(7) is so driven towards the arrow direction that the sample vessel(6) is placed at the sampling position in order. A wedged measuring port(8) for urgent measurement may be prepared.
The sampling part(2) has a sampling nozzle mechanism(11) with two nozzles(9, 10), a hemolyzing-washing liquid pump(P1), a sample suction pump(P2), a specimen injection pump(P3), and a dilution pouring vessel(12). The capacity of the sample suction pump(P2) is 1˜few μl, and that of the washing liquid pump(P1) and the specimen injection pump(P3) is hundreds μl. The sampling nozzle mechanism(11) moves up and down with rotation. The hemolyzing-washing liquid(13) is prepared by dissolving the above-mentioned labile HbA1c degrading reagent and hemolyzing agent in the dilution liquid of sample. In the example, this liquid is also used for washing pumps, nozzles, and other flow-lines. In the invention, a sample(14) refers to a whole blood sample or blood cell layer, and a specimen(15) refers to a solution prepared by diluting the sample(14) with the washing liquid(13) to tens-hundreds-fold.
At the sampling part(2), first a specified quantity of sample(14) is suctioned from the first nozzle(9) by driving the sample suction pump(P2). Next, the sampling nozzle mechanism(11) is moved to over the dilution pouring vessel(12), and the washing liquid(13) is discharged from the second nozzle(10) to wash the outside of the first nozzle(9). For this object, the second nozzle(10) has the tip bent towards the first nozzle(9). The waste liquid is led to a drain bottle(17) at the bottle-unit part(3) through a waste liquid valve(16). Next, the sample(14) and a specified quantity of hemolyzing-washing liquid(13) are discharged into the dilution pouring vessel(12) by driving the pumps(P1, P2). The both(13, 14) are stirred by this discharge. Further, the both may be sufficiently stirred and mixed by repeating suction and discharge by the first nozzle(9). Thus mixed specimen(15) is suctioned from the first nozzle(9) by suctioning action of the specimen injection pump(P3) and fed into the sample injection valve(18) at the analyzing part(4). (the state in FIG. 1 and FIG. 2) Next, the dilution pouring vessel(12), piping, and the first nozzle(9) outside are washed by the hemolyzing-washing liquid(13), and the waste liquid is discarded and preparations for the next sample suction are made.
On the other hand, the specimen(15) fed into the sample-loop(18a) at the sample injection valve(18) is warmed by being held in the warmed sample-loop(18a). The sample-loop(18a) is, as showed in FIG. 3, surrounded by a loop warmer(18b), and further the loop warmer(18b) and the main part of the sample injection valve(18) are covered by a temperature keeping cover(18c). In the figure, symbol(18d) is pipe for specimen, (18e) pipe for eluting solution, (18f) motor,(18g) geer box, and (18h) block for keeping temperature. The temperature keeping cover(18c) is screwed to the block(18h).
In warming by this method, there is no useless energy and no injection of unwarmed specimen part into column(19) because of sure warming of specimen only in the sample-loop(18a).
Next, the motor(18f) of sample injection valve(18) is rotated to the state showed as FIG. 4 and the specimen(15) in the sample-loop(18a) is injected into column(19) by being pushed out by the eluting solution sent from the bottle-unit part(3). Each component of specimen(15), HbA1a, HbA1b, HbA1c, and HbAo, is separated in column(19), and subjected to photometry by photometer(20) in order and discarded in drain vessel(21). The photometric results are sent to microcomputer(5) and each fraction pattern, elution time of peak, and content % of each component are calculated to be printed out at printer(22). When filter(24) is set before column(19) to remove impurities and the whole is kept in a thermostat(25), stable measurements are performed.
Table-1 shows the summary of operations mentioned above based on FIG. 2 concerning the action of pumps(P1, P2, and P3) and the flow state of flow-exchange valve(38, 39) for the hemolyzing-washing liquid(13). In each pump, ↓ shows suction ↑ discharge, and blank stop.
TABLE 1______________________________________pump.valvestep P1 P2 P3 38 39 operation______________________________________1 ↓ ↓ sample is suctioned, hemolyzing-washing liquid is suctioned2 ↑ hemolyzing-washing liquid is discharged to wash nozzle- outside3 ↓ hemolyzing-washing liquid is suctioned4 ↑ ↑ blood sample and hemolyzing- washing liquid are discharged to mix5 ↓ specimen is suctioned and the part is fed to sample-loop to be warmed6 ↑ specimen is injected into coloumn by exchanging sample injection valve and remaining specimen is discharged7 ↓ hemolyzing-washing liquid is suctioned8 ↑ sample-loop and other flow lines are washed______________________________________
In operation mentioned above, hemolyzing-washing liquid(13) of 450 μl for dilution of 1.5 μl of sample(14) is 300-fold in dilution. The optimum conditions of the warming time and temperature of specimen(15) are 2 min 40 sec. at 48� C., though depending on the degradation ability of a labile HbA1c removing reagent, under the above-mentioned dilution in the case of the use of hemolyzing liquid containing a labile HbA1c removing reagent of phosphoric acid compound which is on sale with the name of "21H" by the present applicants. The degradation of labile HbA1c is almost completely made with 2 min at 60� C., 3 min. at 40� C., and 4 min at 33� C.
In the example, 3 types of eluting solution are used. Each eluting solution, (A), (B), and (C), based on the flow sequence, is sent to a manifold(34) in order by each exchange valve(31, 32 and 33) through heating coil(26), cooling coil(27), and debubbler (28, 29, and 30). Each eluting solution which entered one flow line at manifold(34) is sent to sample injection valve(18) by feed pump(35), injected into column(19), and flows into drain vessel(21) through photometer(20) with carrying specimen(15). In the figure, symbol(36) is a pressure detector, and(37) a damper.
In FIG. 1 and FIG. 2, symbol (38, 39) is a exchange valve for hemolyzing-washing liquid(13), (40) a out of liquid sensor for hemolyzing-washing liquid(13), (41) a suction air pump for drain bottle(17), (42) a indicator, and (43) a operation keyboard.
The above-mentioned description is for the case of measuring samples continously arranged, in which case the working in a constant sequence results in a constant time from dilution to injection. However, in case sample vessels are placed on rack(7) uncontinuously because of variation in the time in collecting blood, an excessive irregular time is required to find the next sample. Also in case a sample vessel is set on a wedging port for urgent measurement, the mistimed suction of blood sample may occur. Thus, in finishing injection of specimen(15) into column(19) the next sample is found and, by calculating back from the next injection time, dilution is preferably started timely.
On dilution start, when the missing of the next injection already became clear, the continous operation of one sequence without the mixing and injection of specimen into column enables the stable measurement to continue without harming the column balancing condition even if in the case of the use of 3 types of eluting solution of different concentration or pH.
The blood cell washing method by isotonic phosphoric acid buffer solution, which has been practiced as a standard method for removing labile HbA1c (pretreatment), was compared with the method of the present invention. Table-2 shows the results.
As the results, the method of the invention produced the similar effects with the conventional method in removal of labile HbA1c fraction. Further, compared to the combination of the blood cell washing method and 21H, the
TABLE 2______________________________________ Measurement value (%)faction A 1 a L-A 1 ccondition + A 1 b F + S-A 1 c A 1______________________________________21L 1.5 0.2 5.9 7.421H 1.4 0.2 5.2 6.6"S" + 1.4 0.2 5.2 6.621L"S" + 1.4 0.2 5.2 6.621H______________________________________ F: Glycohemoglobin HbF LA 1 c: Labile HbA 1 c SA 1 c: Stable HbA 1 c "S": Blood cell washing method by isotonic phosphoric acid buffer solutio more lowering of labile HbA1c fraction and the increase of A1a+b by change were not observed.
In the case of no pretreatment and no use of labile HbA1c removing reagent(21L), all values are high. The difference between 21L and other treatments in L-A1c +S-A1c is assumed to be labile HbA1c. In the example, labile HbA1c is ca 0.7% of whole hemoglobin. Measurements were practiced under the following conditions.
21: Hemolyzing-Washing Liquid Without Labile HbA1c Removing Reagent
nonionic surface-action agent 1 g/l
potassium di-hydrogen phosphate 0.1 g/l
potassium mono-hydrogen phosphate 0.3 g/l
pH 7.5
21H: Hemolyzing-Washing Liquid Containing Labile HbA1c Removing Reagent
nonionic surface-active agent 1 g/l
phosphoric acid compound 0.1 g/l
KOH 0.3 g/l
pH 6
"S"+21L: Conventional Blood Cell Washing Method is Used
Washed blood cells are added to isotonic phosphoric acid buffer solution, and labile HbA1c is removed by incubation for 6 hrs at 37� C. with continuous rotary mixing.
Then, the blood cell layer is collected and diluted with 21L to 300˜fold to measure.
"S"+21H:21H was Combined to Blood Cell Washing Method
Similarly, with "S"+21L, the blood cell layer treated with isotonic phosphoric acid buffer solution is collected and diluted with 21H to 300˜fold to measure.
Subject: healthy normal human, test just after collecting blood. Measurement conditions: according to the example method, warming temperature 48� C., warming time 2 min 40 sec, measurement time 4 min, and n=5.
As mentioned above in detail, the present invention relates to the improved method of automatic measurement of glycohemoglobin based on the principle of high pressure liquid chromatography which comprises allowing a number of blood samples collected from each patient as whole blood or blood cell layer to stand by at a sample holding part, sampling just before measurement (before tens sec˜few min), mixing with dilution by hemolyzing-washing liquid containing labile HbA1c removing reagent, and injecting into column of high pressure liquid chromatograph at a specified time after mixing start. As necessary, warming may be made from dilution to injection into column.
Therefore, the invention has the following many excellent effects. 1 Compared to conventional method wherein a long column of high quality is used, more rapid measurement can be practiced and the same degree of accuracy can be obtained. 2 Labor of mixing reagent manually is saved, enabling accurate measurement without error due to manual dilution. 3 Pretreatment is unnecessary because of the use of whole blood or blood cell layer centrifuged it. 4 Since the sample is not diluted by hemolyzing reagent in advance, the change of sample is not occur till measurement and stable HbA1c can accurately be measured by preventing the degradation or change of glycohemoglobin other than labile HbA1c. 5 Since the measurement value is not effected by labile HbA1c, there is no restriction by time of blood-collecting and it is not a burden on patients. 6 Further, since a sample is hemolyzed just before measurement and injected into column always at constant timing, stable measurements can be made. Particularly, since the balancing condition is not harmed even if samples are set uncontinuously, the chromatogram's patterns are stable.
The sample injection valve warms the sample liquid and reagent at specified temperature for specified time. Since only specimen is warmed surely, there is no useless energy and no risk of injection of unwarmed part into column, leading to accurate control. The valve of the invention can be prepared by improving a conventional sample injection valve simply. Since the other warming device is not required, there is a merit of space-saving.
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|U.S. Classification
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|International Classification
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|Fee payment
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Year of fee payment: 12


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Stayed in on New Years eve. The hotel itself is very average, the rooms are small and a bit dated. The staff, however, made up for some of the hotel's lack of charm. The staff was very helpful and nice. The hotel also contains a decent eatery/bar - the Cherry Lounge or something like that. When I first arrived, I was a little concerned about the area but it turned out to be completely fine and much more centrally located than I had expected. Good for people looking to explore Philadelphia's tourist attractions. Also, very close to Reading Terminal Market and Market Street Station.
- Official Description (provided by the hotel):
- No matter how you choose to travel around the city of Philadelphia, you'll love the location of the newest Four Points by Sheraton Philadelphia City Center Hotel. ... more less
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- TripAdvisor is proud to partner with Hotels.com, Expedia, Booking.com, TripOnline SA, Starwood, Hotwire, Priceline, Odigeo and Travelocity so you can book your Four Points by Sheraton Philadelphia City Center reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- 4 Points By Sheraton Philadelphia City Center
- Four Points By Sheraton Philadelphia City Hotel Philadelphia
- Four Points Philadelphia
- Philadelphia Four Points


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Originally posted on BlackSportsOnline | Last updated 2/2/13
Wes Welker has been one of Tom Brady's favorite targets for years now. However, he is scheduled to be a free agent this season. One season after the Patriots decided not to give him a long-term deal and to place the franchise tag on Welker. Could the Patriots franchise Welker again? It's a possibility. As of now, both sides look to want to stay together long-term. But Patriots owner Robert Kraft let it be known that he has a concern about negotiations. Per Tom Curran of CSN New England: "I'd love him to be around, he's a great guy," Kraft said of Walker. "Like I said all along, it takes two sides to make a transaction and then we have to manage the lawyers and the agents that they don't mess it up. I think Wes wants to be with us and we want him here so it's just a matter of whether both sides can be intelligent." We'll have to see if the two sides can come to an agreement. I'm sure Welker loves New England, but he might have to be willing to take a hometown discount to stay there for the long haul.
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text: Tim Gunn Is Feeling SmurfyRichard Lawson5/06/10 1:56pmFiled to: Castingtim gunnSmurfsDefamerStrange thingsProject Runway40EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalink The fashion maven and Project Runway mentor has been cast as "an exec assistant at a major cosmetic company" in the upcoming live-action/animation Smurfs movie. So, yay. But, uh, why is there a cosmetic company in a Smurfs movie? [Variety]Reply40 repliesLeave a reply


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0 of 1 people found the following review helpful
Everyone Must Read,
This review is from: Millionaire Teacher: The Nine Rules of Wealth You Should Have Learned in School (Paperback)
I was reading Money Sense magazine while half asleep and turned the page and read "When I lived on Vancouver Island in 1999, I started a investment club with a number of fellow school teachers" and looked up to see a drawing of my grade 7 teacher staring back at me. I was shocked. The guy who I remember racing on a tandem bike with his wife and jumping on desks and telling stories that would keep the sufferer of the highest case of A.D.D glued in anticipation is also a very accomplished writer and investor. I immediately ordered the book from Amazon and hammered through the book in a couple of days. This book is the investors version of the Wealthy Barber, knowledgeable yet straightforward and easy to read. I loved how it compiled the best of many books while using concrete facts rather then stipulation like most investing books. Also, having the game plan laid right out of what index funds to buy depending on what market you are in. Makes everything sound so easy.
My money sense isn't that great. Though I am self-employed and like reading about the world, economies, industries and finance I have a hard time pulling the trigger on investments that I have no control over. I watch the stocks on my phone but have never bought any, just relying on my financial adviser, which now I know loves to sell items that won't help me like GIC's and mutual funds. In reading this book I now know that I have a lot of better options and will put his advice to good use.
This book is a must read for anyone,
Garth O'Neill
Review Details
Top Reviewer Ranking: 36,458,911


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I want to start today by thanking our chamber for organizing another successful Business Matters Breakfast. I want to thank my colleague, Jim Watson, for his initiative in securing my attendance. I also want to take this opportunity to speak to you, the representatives of the business community, to say something to you on behalf of Ontarians 12 million strong. Thank you. Thank you for the work that you do. Thank you for the risks that you take. Thank you for the jobs that you create. Thank you for the families that you support and thank you for the invaluable contribution that you make to our shared quality of life. As Premier and as a leader one of the things you have impressed upon you, is that you only really have access to the macro level levers when it comes to job creation. Governments don't create jobs. We can lend shape to the environment in which you create those jobs. This economy has generated about 177, 000 jobs since we earned the privilege of serving Ontarians as their government and I didn't create those jobs. You created those jobs and we are very grateful. Thank you very much. I also want to recognize members of our eastern Ontario team who are here this morning. They're sitting down for breakfast right now. But you can usually find them standing up and speaking up for Ottawa and eastern Ontario at Queen's Park. Whether it's Madeleine Meilleur fighting to keep the Montfort open. Or Richard Patten's passionate battle for a new Royal Ottawa Hospital. Or Jim Brownell ensuring we follow through on our commitment to the sexual abuse inquiry in Cornwall. Or Phil McNeely's dedication to transportation issues in the east end. Or Jim Watson's lobbying for Algonquin College's fair share of the $6.2 billion we're investing in postsecondary education in the province. Or Jean Marc Lalonde's work to ensure fair treatment for area construction workers in Quebec. These hardworking men and women are making a difference for our community. And I'm proud to call them not just colleagues, but friends as well. I'm not sure if it's ever been more fashionable than today in the 21 st century to be cynical. Cynical about politics, cynical about politicians and our political institutions. You should know that for me and my colleagues; politics remains very much a high calling. It remains the single most important method by which we can come together and overcome those challenges that are too great for us to overcome on our own. We cannot build schools and staff them with teachers on our own. We cannot build hospitals and staff them with doctors and nurses and the necessary technology on our own. We cannot build roads or grow this economy on our own. I have this powerful ideal that says that when we come together, when we aspire to something beyond ourselves, we can actually do great things. 136065 101 Air Jordan 1 Retro White Silver Navy ,656503 010 Air Jordan Future Black Black White Air Jordan 3 Retro 88 White Cement Women Size Air Yeezy 2 Red October 2014 Kanye West Shoes 656503 010 Air Jordan Future Black Black White Nike Kobe 9 Low EM Premium Laser Crimson 543390 127 Women Size Air Jordan 6 GS Grape Air Jordan 11 Low IE Black Varsity Red Air Jordan 3Lab5 Black Metallic Silver 136066 041 Air Jordan 1 Retro Black Blue Famous as the Japan ASICS running shoes, the American top four running shoes are also enjoyed the world popular fame: BROOKS, SAUCONY, and NEW BALANCE. And around the world, they are the most recognized best running shoes. Established in the year of 1914, Brooks was a company specializing in the production of professional sports goods. Its unique range of footwear technology including: Hydro Flow liquid buffer power systems, high tech twill weaving techniques ensured the shoes upper in line with the actual foot shape, vinyl resin midsole reinforced technology. Podular Technology, by using 257 materials and according to the ergonomic design, ensured the most comfortable feet feeling to the user. The five layer precise structure provided Brooks an excellent cushioning performance and the perfect quality insurance. According to the general foot type, flat feet, high arches and other foot type consumers, Brooks designed different professional technologies to meet the various shoes demand. In shock absorber technology, Brooks adopted the Hydro flow (liquid flow) technology, which consist of room temperature viscous material bags, convenient liquid flow and a number of shock absorber channels. The cushion bags in the heel portion are not only functioned as a buffer but also can do positive and stable effect. SAUCONY enjoy the reputation of "the Rolls Royce of sports shoes brand" in the United States, the company is headquartered in the United States, with 100 years of history, and the products are divided into two broad categories, one is the professional sports series, and the other is the recreational sports series. It is the world's top four running shoes brands. Half a century ago, America's first spacewalk astronaut White was wearing SAUCONY to walk in the moon. The most characteristic of SAUCONY sports shoes is that it can meet each individual's foot type and gait to achieve their best protection and motion effect. The GRID system is the world recognized technology which can provide cushioning and stability features in its midsole part, and it is recognized as the core technology of the SAUCONY sports shoes. Runners who wear SAUCONY running shoes are ensured with the best protection and movement efficiency. With the continuous development of business, New Balance began to make professional sports shoes for local runners in the 1950s and entered the sports shoes industry in the 1960s. The current chairman and chief executive James S Davis open the new prologue of New Balance as he bought New Balance in the 1970s Boston Marathon day. made imports shoes. The exclusive research and development of high shock absorbing technology "multi functional" shoes was enjoyed the fame of the "President's jogging shoes", and was favored by multi country state heads and elites, because of its 99% perfect ground reaction force absorbing skills. 136065 101 Air Jordan 1 Retro White Silver Navy,jump to contentmy subredditsMODERATOR OFwhat's this?TROPHY CASE I been losing workout gear everywhere. First I lost my wrist straps. No big deal, right? I only spent $15 on them so they can easily be replaced. Next I lost my belt. My fucking Sheik belt! I left it at the gym by mistake and somebody must have taken it because it didn make it way to the lost and found. Since then I lost my favorite lifting sweater and just last night I lost my ab roller. I brought it to a local park to use between sets with my gymnastic rings and it rolled away in the darkness. I tried looking for it and couldn find it. I went back this morning and it nowhere to be seen. I did this in the beginning. I rode my mountain bike and I felt that was enough. Eventually I got into running and I ran so much each week that I wouldn even consider a leg day in the gym. Then one day I ran past a set of stairs on my route, and decided to run stairs for fun. The challenge and instensity of stairs was far better than distance running. Soon I found myself doing plyometrics and even practicing my squats. Within a year I moved into the gym and worked on my plyo even more, got decent at hi bar squatting and continued to play on stairs. Now, 3 years later, I can squat nearly 3x my BW and I can still run 15km. I can run distance as fast as I could before, but my legs are far healthier. I stronger, faster, more powerful, and I still retain the ability to run long distance alberit a bit slower than before. In short, skipping legs in the gym isn necessarily a bad thing if you aren concerned with physique/size or strength. Just remember that you can have you cake and eat it too if you want to be a recreational runner. In your case, since you training for a marathon, it not all bad to skip leg day. Just the same, squatting builds up your hip flexors which runners are notorious for being weak in that department.
You Will Have a Good Time While Buying Discount 136065 101 Air Jordan 1 Retro White Silver Navy,Air Jordan 11 Ultimate Gift of Flight People taking statins to reduce cholesterol may feel a false sense of security and overindulge in unhealthy foods, according to a new study. Statins are prescribed to reduce cholesterol and as a preventive measure for heart diseases. Millions of Americans are prescribed statins each year, either after a stroke or a heart attack. Statin users' caloric intake increased by 9.6 % in 2009 2010 compared with those on statins in 1999 2000, according to a UCLA led study published on the JAMA Internal Medicine site. Researchers compared the intake of calories and fat and measured body weights among statin users and non users over a 10 year period, using data from the National Health and Nutrition Examination Survey. In 1999 2000 the intake of fat and calories was lower in statin users than in non users. The difference of caloric intake became smaller over time, and by 2005 2006 there was no difference between the groups. By 2009 2010, fat intake was up by 14.4%, and the body weights of statin users had also increased, while non users saw no significant increase. Under new guidelines by the American Heart Association implemented in November, more people may be recommended statins as a preventive measure. The change in the last few years could be driven by several factors, according to Takehiro Sugiyama, a clinical fellow at the National Center for Global Health and Medicine in Tokyo, who led the research while a visiting scholar at UCLA. "Statin users check their cholesterol levels regularly, so they may learn they do not need to restrict their diet to achieve (cholesterol) level goals," says Sugiyama. As Americans' waistlines increase, physicians may be prescribing statins to people who also eat more, says Sugiyama. Cardiologists usually recommend statin users change their diets. The worry is that people on statins may feel like the pill allows them to continue eating as they choose. Robert Eckel, an endocrinologist, and professor at the University of Colorado Denver School of Medicine, says that while he would like to see the study validated in another population, the study highlights that statins shouldn't be thought of as a free pass. "It's pretty clear people who eat heart healthy have less strokes and heart disease," Eckel says. "This doesn't mean you can't have birthday cake at your son or daughter's birthday, but the overall diet is what counts." While there isn't currently a link between dietary modification and statin effectiveness, Sugiyama says when doctors prescribe statins they want to decrease cardiovascular risks and obesity. He says the message is that doctors should continue to stress nutrition with patients on statins. Sugiyama says another long term study will be needed to identify the different dietary intake trends of the users, including whether the group began eating more because they started taking statins or if the users were more likely to eat and weigh more prior to treatment. "Extrapolating from our study result, we can predict that statin users in the future will eat and weigh more than current statin users do," Sugiyama says. "This change will offset cholesterol lowering effect of statins to some extent." 136065 101 Air Jordan 1 Retro White Silver Navy jump to contentmy subreddits limit my search to /r/malefashionadviceuse the following search parameters to narrow your results:see the search faq for details. Any kind of or toe is usually frowned upon, but whatever floats your boat. Regarding longevity, a shoe with a leather sole fully stitched (not glued) on will last a lot longer as it can be resoled by a competent cobbler. Alden and Allen Edmonds are very well respected brands, but are quite pricey. Some people enjoy badmouthing florsheim, but I think their shoes are quite reasonable for the price. I heard good things about the veblen, but it may still be a bit expensive and stock is running low. Also, shoes are one of those things that you really want to try on before buying. They fucking hideous. Did you do any research whatsoever before making this post? It a rhetorical question because I can tell you didn I know this because literally the first piece of advice anyone gives anyone looking for shoes is you never get a fucking square toe. I not sure how the "square toe looks great!!" meme got started, maybe it some particularly nasty strain of H1N1 virus, no clue. Don get me started about the "detailed stitching," fucking Christ on a cracker. Get one of these, all available on Zappos, just do a search: Allen Edmond Lombard or McAllister even a damn Rockport Ellingwood or MarginThe second half of your post is useful to the OP. Thanks for taking the time. Your first half shows that you a complete ass hat. Did you do any research whatsoever before making this post? It a rhetorical question because I can tell you didn Is that how you communicate with people face to face or do you just grow balls when you online?
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Co-Sourcing Improves Pharmaceutical Laboratory Productivity
Capitol Hill Critics Second-Guess Agencies Using...
Keep the Opportunities, Lose the Opportunists
Clinical-Style Validation, Regulation, and Quality Control...
After several years of calls for a mandatory genetic tests registry from Genetic Alliance, the Genetics and Public Policy Center, the Coalition for 21st Century Medicine, and others, the National Institutes of Health (NIH) has finally taken the first step toward creating a single public resource that provides detailed information about genetic testing providers and the more than 1,600 genetic tests they offer.
The new Genetic Testing Registry (GTR), to be housed at NIH, will be distinguished by its comprehensive nature, requiring evidence of test done, protocols, reagents, and enough parameters to discriminate between the same tests done in different labs. According to the NIH, the GTR will:
Until now, there has been no comprehensive information available about tests for providers, payers, patients, and consumers to make comparisons and evaluations. The GTR will build on a foundation of openness to create such a resource.
NIH will complete a broad consultation with potential users and submitters while the GTR is being established, which will be integral to its usability and success. All prospective stakeholders, including genetic-test developers, test kit manufacturers, healthcare providers, patients, and researchers, as well as other agencies, such as the Food and Drug Administration and the Centers for Medicare and Medicaid Services, will provide input.
In addition to the valuable feedback each stakeholder group will provide, this demonstration of transparency and collaboration in and of itself is an important indicator of future success for the GTR. Novel partnerships among all stakeholders are crucial for the development of innovative, forward-thinking solutions. Initiatives are only truly collaborative while an environment of openness is maintained.
Sharon F. Terry ([email protected]) is president and CEO of Genetic Alliance. Click here for more information on the Genetic Testing Registry.
Sharon F. Terry ([email protected]) is president and CEO of Genetic Alliance. Click here for more information on the Genetic Testing Registry.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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I've also got a comp with navy blue in the background, and the type knocked out. Tough choice.
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ORLANDO, Fla. (AP) - Orlando International Airport may be one of
the busiest in the country, but federal officials say too many of
it's air traffic controllers have too little experience.
U.S. Department of Transportation Inspector General Calvin
Scovel cited Orlando as having the nation's highest percentage of
controllers in training to become certified. Forty-seven percent
lack certification -- about double the percentage of uncertified
controllers nationwide.
Orlando has the 11th largest passenger volume in the U.S. Payroll records from an employees union show about half of the 32 controllers there have five years or less experience.
Federal Aviation Administration officials say safety is paramount, adding that the controllers are watched by experienced supervisors.


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U'Netaneh Tokef -- Will We Live?
Ariel Gros-Werter | Posted 11.04.2013 | Religion
Read More: Rosh Hashanah, Unetane Tokef, Religion News
Our attachments can be obstacles: the stuff we keep that clutters our physical and mental worlds, the slight we can't ignore that distracts, a grudge against an acquaintance that keeps us from enjoying companionship, rude comments that make us angry. All these stand in the way of engaging in our lives and realizing possibilities.


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Glucose Essentials® (90 capsules, 1-month supply)
Item## GES
…weeks2. And in a 12-week, double-blind, placebo-controlled trial, participants taking Portusana also saw blood sugar improvements. Silbinol® 450 mg Silbinol is extracted from the heartwood and bark of the Indian Kino tree, a tree native to India, Nepal, and Sri Lanka. It's exceptionally…


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Just when you figure Asian kids growing up in States would catch on to our great sports heroes, Kevin comes along on Jeopardy's Teen Week and destroys that myth. Watch as Kevin acts like a smartass and buzzes in on this "Super Bowl MVP" photo clue. (Hint: It's Eli Manning).
If there's one thing goofy white kids can still kick an Asian's ass, it's in stupid sports trivia.
Posted: April 9, 2012
Premise of Video: Jeopardy. Asian bro. He's going up against Rose; she's obviously book smart but couldn't tell you how to run drugs from Northern Michigan to Miami, Florida. Then there is some bro with a weird name. He seems to be overwhelmed.
Climax of Video: It's not Aaron Rodgers, you worthless idiot. Go solve cancer, or something.
Conclusion: -900 his name isn't Kevin. Best bet of the week.
Filed under: Video
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Property Management
Remstone offers a full range of commercial property management services. For more information click the link below.
We like to think of ourselves as more than building contractors. Our contemporary outlook coupled with our traditional skills, sets us ahead of the usual run of the mill builders.
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Remstone has a wide range of residential or student properties available to rent. For more information click the link below.
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