text:
The final room was nice, cozy and the bed was very comfortable, and the bathroom as very nice.
First room was non-smoking and obviously had a smoker in it. Second room had a shower head that wouldn't stay put because the plastic had rubbed off where it was held, so had to turn the whole holder to have it shower straight down. Second room's AC wasn't working as it said the room was unoccupied till sometime in the middle of the night. We also didn't get our wakeup call because the staff forgot to change the room number when we got our new room. Luckily we set our own alarm. When told about the issues the staff suggested we needed to call and they'd fix it and otherwise didn't care much.
The beds are small
Clean and comfortable hotel with a bathtub (rarity in Scandinavia!). The included breakfast was extensive and delicious. Also, the airport shuttle was extremely convenient for our needs.
The advertised airport shuttle does NOT run all day. Luckily for us, it covered the times we needed it but I can easily imagine it inconveniencing other guests if their flights arrived/departed during off-times.
Very comfortable overnight stay. Appreciated the free shuttle service to the airport.
The staff were very friendly and most helpful and the hotel had a lovely homey feel to it.
The bed was old and noisy
One train stop from airport, close to good walking paths, moderate price in expensive city
Guest rooms very small, extra charge for breakfast
Nice location, frindly staff, close to train station, airport
Good and clean hotel with free parking.
Lack of elevator was surprising.
Very clean.
Friendly staff.
Great breakfast.
Room too hot. Window opens only slightly, and right next to noisy, brightly lit road. To cool the room I had to open the window, and suffered from noise and light.
Bed sags somewhat in middle.
Pillow was lumpy, and no extra pillow.
Duvet was too warm, but there was no alternative (no top sheet, no light blanket).
In short, this was the worst sleeping experience I've had at a hotel in years.
right across from train station
perfecly silent in the room; no noise from the train station (really impressed by that)
the bed was very comfortable
the lobby felt up-scale
there was a tiny bit of mold/mildew in the grout in the shower (not a big deal)
the outlets and switches were not in convenient locations (not a big deal)
The room was a nice size, with a door opening onto a green area. Nice bathroom. Free wifi. Was told it was an upgrade from my original booking. That makes me worried about what the intended room was like, since this is what I had expected.
Breakfast not included because I booked the room through kayak. Staff was not very friendly or helpful (because I was a "second class" guest?).
The staff were impeccable, I was treated extremely well. The selection of eatery's on the premises was fantastic - I didn't need to leave the hotel at all!
Only the view, really, although the window was a bit pocky. The lady at the front desk was very helpful.
The gym/swimming pool area was very disorganized. The attendant was on the phone and was not giving us the right information so we had to keep coming in and out of the changing rooms because he forgot to give us the right keycard, then the towels ...
The location eight next to the train station
When we arrived after an overnight flight, feeling very tired, the hotel computer was down and we had to wait for a coup[e of hours in the lobby for it to be fixed.
The hotel should have made some sort of small gesture to compensate us for this.
Also the breakfast included thawed frozen fruit which had turned rancid one day. The next hotel in Bergen had FRESH fruit. like melon, cantaloupe and kiwi. was was cut up and delicious.
Staff was awesome.
The towel I used in the AM looked like someone had previosly used it for toilet paper. Grossed me out. Not something you'd expect at a higher $ hotel.
good location with walking access to center and Vesterbro,
nice view over Copenhagen
bathroom cramped, wifi spotty
hotel staff kind, quick, precise
bathroom, small, old, unpleasant
Not really
Location is close to the central station
Located in the "cheap hotel district" this is exactly what we were hoping for from our stay! Terrific location (next door to the main train station), clean hotel, nice staff with easy check-in/check-out process, and a breakfast buffet that gives you a little taste of what the food will be like! Enjoyed our stay!
Rooms are small which we knew. Also, buffet does get crowded as others have mentioned but would recommend for a fine spread of bread, meat, eggs, and some fruit! Would also recommend bringing your own soap/shampoo.
Great location. Close to central station. Great service from the front desk. Good breakfast.
Some rooms require to take few steps of stairs with no ramp. Not good with big luggage (or elderly).
Great location. Easy reach of town center, sights and transport.
Good facilities. Room was comfortable, warm and well appointed.
Reception staff and room staff were all fantastic.
Close to a small supermarket and across from a great little Italian restaurant - Tio Mario, as well as the adjoining hotel restaurant Ottos which did a good breakfast.
Both very minor niggles....Toiletries provided were slightly haphazard - shampoo and conditioner only one day, shower gel and shampoo the next!
Jacuzzi could have been a bit warmer .....
The studio apartment room had lovely interiors. We rented bikes from the hotel which was really great. However the lack of free internet in the rooms was definitely a downfall. The free internet in the lobby was a little spotty. The location was a little far removed, but at least it was close to a train station.
The breakfast menu needs improvement.
I liked the high standard of the design, which was not luxurious but of a very good taste. My bedroom was clean and had very good proportions, not too small for one person. The breakfast was excellent. And I loved the view from the room with the balcon at 6th floor.
The bed was very comfortable, as was the room.
The parking was acceptable but using a local/pay parking system. Breakfast was not acceptable at all, runny eggs (and this was earlier in the breakfast cycle) and the sausage was cold.
Please write at least 15 words
No bathtub
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text:
Personal view: a potential novel treatment for fatigue complicating chronic liver disease – how should its efficacy be evaluated?
Version of Record online: 30 MAR 2006
DOI: 10.1111/j.1365-2036.2006.02862.x
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 8, pages 1113–1116, April 2006
Additional Information
How to Cite
JONES, E. A. (2006), Personal view: a potential novel treatment for fatigue complicating chronic liver disease – how should its efficacy be evaluated?. Alimentary Pharmacology & Therapeutics, 23: 1113–1116. doi: 10.1111/j.1365-2036.2006.02862.x
Publication History
- Issue online: 30 MAR 2006
- Version of Record online: 30 MAR 2006
- Publication data Submitted 27 December 2005 First decision 23 January 2006 Resubmitted 26 January 2006 Accepted 31 January 2006
- Abstract
- Article
- References
- Cited By
Profound fatigue is a clinically significant complication of chronic liver disease. A mechanism of fatigue in experimental animals and male athletes appears to be increased serotoninergic neurotransmission in the brain. Recently, attempts have been made to assess the efficacy of a serotonin antagonist, specifically the 5-HT3 receptor subtype antagonist, ondansetron, in ameliorating fatigue in patients with chronic liver disease.
However, the results of a randomized controlled trial of ondansetron for fatigue in patients with primary biliary cirrhosis did not indicate that ondansetron was either effective or ineffective. The reasons for the uncertain outcome of the randomized controlled trial are not clear. One contributing factor may have been the use of subjective indices of fatigue as primary efficacy endpoints. There is a need to develop objective quantitative primary efficacy endpoints for use in trials of therapy for fatigue.
Another contributing factor may relate to the conduct of a randomized controlled trial not invariably being the optimal approach to resolve a specific clinical issue, particularly when the application of statistical methods yields equivocal findings. When the results of a randomized controlled trial are indecisive, findings based on clinical judgement, medicine's most important asset, should be carefully evaluated.

subset: commoncrawl


text:
WhitePages: Ya Hsu in SC | WhitePages
View Ya Hsu's phone number, address and more on WhitePages. Find 2 listings for Ya Hsu in SC. WhitePages is the largest and most trusted directory, and has ...
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Hsu Hsu-Hui, Taiwan Express Co Ltd: Profile & Biography - Bloomberg
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View Kuang-Hui Hsu's (China) professional profile on LinkedIn. Financial Forecast Experience: Auditor, KPMG.
LinkedIn: YA HUI HSU | LinkedIn
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LinkedIn: Yueh-Ya Hsu | LinkedIn
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LinkedIn: Ya-hui Hsu | LinkedIn
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Tzu-Hui Hsu - Patents
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Chih-Hui Hsu's Inventor profile, New Taipei, TW, VIVOTEK INC.;, 3 patents/applications from Mar 31, 2010 to Jul 05, 2011, 13 forward patent citations,...
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Po-Ya HSU's Inventor profile, Fongshan, TW, YA THAI CHEMICAL CO., LTD.;, 4 patents/applications from May 02, 2003 to May 22, 2008, 2 forward patent citations,...
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Yen-Ya Hsu's Inventor profile, Taipei, TW, INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE;, 6 patents/applications from Dec 16, 2008 to Jun 05, 2012, 6 forward...
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View Yen-Ya Hsu's professional profile. Publications: 12 | Citations: 5 Field Rating: 1. Fields of study: Electrical & Electronic Engineering, Computer...
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text:
Definición de costing en inglés:
sustantivo(often costings)
1The proposed or estimated cost of producing or undertaking something: he obtained costings for manual keyboarding of the records
Más ejemplos en oraciones
- 'We have presented all our costings to the regulator and he will make a determination thereafter,' the spokesman said.
- Brochures and costings are to be obtained with the possibility of new equipment being provided on the play area.
- We will then be able to present some options with costings.
1.1 [mass noun] The process of calculating a costing: detailed costing can make the difference between an excellent idea and a ruinous one
Más ejemplos en oraciones
- Target costing is a process of determining a maximum allowable cost for a product by subtracting a desired profit from the product's market price.
- We take firms through a process called activity-based costing.
- Energy modeling and lifecycle costing can give facility executives a solid idea of the costs and benefits associated with their choices before a facility is built.
Palabras que riman con costingfrosting
For editors and proofreaders
Saltos de línea: cost|ing
Definición de costing en:
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Los comentarios que no respeten nuestras Normas comunitarias podrían ser moderados o eliminados.
Muy popular en Reino Unido
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= de moda


text:
"Very Good Listen"
It's been awhile, however, I enjoyed this story. Yes, I did get it on sale, thank you AUDIBLE. It took me awhile to come back to this series. Don't know what was happening then but I wasn't enjoying the series. However Kim Harrison and the Marguerite Gavin are back.
I loved all the twists and turns that happened in the story and I became familiar again with Rachel Morgan's friends, Ivy and Jenks. This is one of her best, I believe. I really enjoyed Book 9 and look forward to more Rachel, the half demon's adventures.
"Rachel Morgan and Trent"
Had to listen to this book twice because the nuances were such that I wanted to really under stand what was happening to Rachel &Trent and how the relationship between them would play out.
Rachel is not slow on the uptake but that kiss she and Trent had should have told her something.....I just didn't think she got it from the story's ending.
Rachel is a very passionate person. She gives her all for those she loves. Trent knows that. Ivy knows that, and yet. . . This ending was a bit flat....
All the books leading up to this one were entertaining but it gets tedious constantly waiting for Rachel to smarten up. In this book she finally realized that everything is not black and white but varying shades of grey. She realizes that others that she considered "evil" were merely doing what they believed they had to for what they cherished, very much the same way she did what she did to end up where she is.
I can't wait to see what decisions she makes in the next book (A Perfect Blood") now that she has cone to terms with who and what she is.
On another note I hope that they keep Marguerite Gavin as the narrator as she is truly the voice of the hollows, they tried to change it up once and I could hardly even make it through the book. She is amazing in the way she captures the essence of each character and I cannot imagine any other narrator doing these books justice.
"I Love Rachel Morgan"
I Love Rachel Morgan! Kim Harrison+ Marguerite Gavin = A perfect Rachel Morgan! Everyone of these books are so much fun to listen to (With the exception of "The Outlaw Demon Wails', which unfortunately had a different narrator. But was still an excellent story). Marguerite Gavin is one of my favorite narrators. She takes books to a different level. For me, the story teller can either ruin a good book, or can make "a not so good" book better. But when you have a great Author paired up with a fantastic Narrator, it makes the audio book experience superb! Pale Demon, is the most epic book in the Rachel Morgan series yet. Opening the doors for a different kind of adventure in the next book. As always, Kim Harrison writes one helluva story.
"Love the series, love this book!"
I love the characters, love the way they have developed, and this particular one is even better than I dared hope. Really. No kidding. Ms. Harrison has created a world that despite it's total improbability, I nonetheless find believable ... and very enjoyable. The relationship between characters and species is rich, complex and evolves from book to book. I sense that the author is beginning to head toward the end of the series. I hope I am wrong. I am a dedicated fan and look forward to each book, then read it multiple times in print and in audio. Great stuff folks.
I love listening to audio books because I have little time to read. Faves are paranormal/sci-fi, with romance & inspirational thrown in.
"Best of the Series"
I waited quite a while to listen to Pale Demon after buying it on sale. When I started listening, I wasn't sure if it would be as good as I had hoped. Well, it exceeded my expectations and I think it's the best book of the series. It has a little different feel than previous books but we got to explore more of Rachel and her men.
Even though the book wasn't exactly a cliff hanger, I found myself thinking that it couldn't end this way. I don't want to wait another year to find out what happens (and of course, we all know what path Rachel will choose) and possibly who Rachel's love interest will be.
I'm definitely on board for the next book in the series and I think Marguerite Gavin is an exceptional narrator.
I love to read, but I am time-limited. Audible allows me to keep up with all my favorite authors while on the hiking trail. Thanks, Audible!
"Is the childish bickering finally over?"
An alternative reality caused by a GM tomato-induced pandemic with transgenic witches, tycoon elves, and libertine demons? What???s not to love? Kim Harrison consistently writes tight and interesting stories, and Pale Demon is a solid addition to the Rachel Morgan series. In this book, some long-standing issues start to be resolved, but when did Rachel get so dumb? Al and Trent are back and still fantabulous. Pierce is back and still annoying. Unfortunately, Ivy???s character has lost some of its dimension, but Jinks is still full of Tinkerbell love. Of course, Marguerite Gavin is brilliant. Finally, a two-credit price for any book in this genre is ridiculous. Even ???A Game of Thrones??? by George R. R. Martin is only one credit and that is a long, award-winning book.
I was so in love with this series. I listened to books 1 - 7 one after the other. Couldn't wait for book 8. The same for book 9. I'm currently 3/4 through book 9, still slogging through, hoping it will get better. It's so different from the other books in the series. The setting, the way the characters relate to one another. I'll listen to book 10, but if it continues going the same way, I won't be listening to 11.
Love this series. Keep them coming and never lose Marguerite. She's as much a part of this series as any of the characters.
"love them all"
the hollow rock..I would love to move there, even get a pixie garden of my own


text: ASP.NET, Classic ASP and SQL Developer Hourly - Entry Level ($) - Est. Time: More than 6 months, Less than 10 hrs/week - Posted Looking for a experienced developer in technologies ASP.NET, C#, SQL Server, T-SQL, Classic ASP, VBScript for long term maintenance & enhancement work of websites on regular basis. Skills: SQL ASP.NET C# CSS


text:
On Second Thought is a one-hour, daily news talk show that airs at 9 a.m. ET weekdays.
Re-examine the shocking story of Leopold and Loeb, who murdered a 14-year-old boy in 1924. Tuesday, July 26 at 7 PM
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Make your secure online donation at GPB.org.
The Georgia Department of Labor and Gwinnett Career Center are hosting a "Veterans" Job Fair Wednesday April 3.
The event is being held from 9am to noon at the Aviation Institute of Maintenance, 2025...


text:
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Florida Keys Outreach Coalition, Inc
phil smedstad wrote:
Several members of my congregation and I just toured the FKOC facilities this past Sunday. We are all most impressed by the professionalism... more »
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text:
alcohol-soft.com CD and DVD Burning Software - Alcohol Soft copy and virtual drive software Alcohol 120 and 52% Free Edition
Alcohol is CD / DVD burning copying backup recording duplication emulation and creation software.
Keywords: dvd burning software, dvd duplication, cd recording, mp3 converter
uk-muscle.co.uk Bodybuilding Forum - UK Muscle Bodybuilding Forum
UK Bodybuilding Forum for weight training, workout routines, bodybuilding diet and anabolic steroid discussion.
Keywords: testosterone, tren, bodybuilding, Athletics, how does dianabol work
alcohol-120.en.softonic.com Alcohol 120% - Download
Alcohol 120%, free and safe download. Alcohol 120% 220.127.116.1112: CD and DVD recorder that can also create virtual drives. Alcohol 120% is a powerful...
lifestyleandstrength.com Lifestyle and Strength - The lifestyle site for those devoted to a strong body, a healthy mind and a well-fed soul.
The lifestyle site for those devoted to a strong body, a healthy mind and a well-fed soul.
Keywords: diet, weight-loss, training, healthy-living
collegedrinkingprevention.gov Research about Alcohol and College Drinking Prevention
Alcohol policies at College Drinking, Facts about alcohol, Research on alcohol abuse, Research on binge drinking, Binge drinking and college students, Alcohol abuse and college students, College alcohol policies, College presidents and alcohol, High...
Keywords: college drinking, College students drinking, Alcohol abuse and college students, drinking, journal of studies on alcohol and drugs
alcoholfree.co.uk Non-alcoholic wine and alcohol-free wines, alcohol-free beer and low-alcohol beer : The Alcohol-Free Shop
The Alcohol-Free Shop are suppliers of non-alcoholic wine, alcohol-free wines, non-alcoholic beer, alcohol-free beer, de-alcoholised wine and other products without alcohol
Keywords: non-alcoholic, alcohol free beer, alcohol free wine, Alcohol free, non alcoholic wine
about-alcoholism-info.com About Alcoholism Info | Effects of Alcoholism | Facts About Alcoholism
Facts About Alcoholism. Learn about alcoholism and depression, alcoholism facts, and how alcohol abuse effects can often trigger negative alcoholism signs.
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mywayout.org Treatment for Alcoholism | Help for Alcoholism | Medication for Alcoholism | Alcohol Treatment Program | How to Stop Drinking - My Way Out
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Vino sin alcohol, Alcohol Free - www.bebidasin.com es una tienda Internet, especialialistas en vino sin alcohol; vino desalcoholizado o con una gradación muy baja de alcohol. Bebidasin is an internet shop which specializes in the distribution and...
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text:
Best Bar in a Warehouse
If David Lynch were scouting for locations around Fort Lauderdale to film his next bizarre odyssey, chances are that Charlie's Rustic Bay Inn would be near the top of his list. But even if Lynch doesn't introduce dancing midgets, locals can say with some certainty that this is one of the weirdest watering holes around. Wedged between auto body shops in a forbidding industrial neighborhood, Charlie's looks like a place you'd bring your truck to have the engine valves adjusted. But inside the tiny, smoky, wood-paneled room is a small range of liquor and bottled beers peeking from an old cooler. The clientele is rough, gruff, and seedy -- just the type you'd expect at a clandestine joint such as this. But the real attractions are the tag-team servers behind the bar. These pneumatic women exude a certain scent of naughtiness that makes one wonder what might happen if the mood were to strike them. Imagine the possibilities.
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text:
If you have troubles since the update to WordPress 4.5 please read this post before opening a new thread.
Tagged: corona, navigation, nested, sidebar
Hi guys, i think the sidebar navigation for nested subpages its a good thing… but i need to get those ads to display first. So please let me know where in the code should i make changes for displaying the automatic sidebar navigation after the widgets… getting it in the midle would be more complicated, doesnt??
many thanks.
open up sidebar.php and move following code:
* Display a subnavigation for pages that is automatically generated, so the users doesnt need to work with widgets
if($subNav && isset($post) && is_object($post) && !empty($post->ID))
global $post;
$subNav = false;
$parent = $post->ID;
if (!empty($post->post_parent))
$ancestors = get_post_ancestors($post->ID);
$root = count($ancestors)-1;
$parent = $ancestors[$root];
$children = wp_list_pages("title_li=&child_of=". $parent ."&echo=0");
if ($children)
$default_sidebar = false;
echo "

";
echo $children;
echo "

";
– i.e. put it before:
//default dummy sidebar
The topic 'moving sidebar navigation' is closed to new replies.


text:
Hourly - Expert ($$$) - Est. Time: More than 6 months, 30+ hrs/week - PostedSkills: eBay Marketing eBay Listing/Writing eBay Web Services SEO Keyword Research
We are currently looking for Ebay experts who can: -Speak fluent English - Handle all aspects of an Ebay Store including listing products, filling orders, customer care and following policies - Create quality listings - Optimize listings using proper SEO - Provide consultation services and answer all Ebay questions. Why work with us? It's a blast to be a FreeeUp worker! You have opportunities to: - Earn your desired wage rate - Secure long term positions with reputable companies - Land a position within FreeeUp to help grow the company - Increase your skill sets through new positions


text:
We'd love to hear from you!
The Association for Early Childhood Educators (Singapore) – AECES is a professional body committed to promoting professional development and collaborating with the community for the well being of children and families.
Our vision is that the early childhood educator is recognised as a professional who makes a difference.
CLICK HERE to view our Programme Calendar for year 2016.
Click here to view e-newsletter.
Dear all, Please click here to view the E-Newsletter.
Please submit your CV to firstname.lastname@example.com. Shortlisted applicants will be informed by email in August 2016 to […]


text:
Tay Zonday explains the history of Minneapolis's transit system
Local history buff Nokohaha dug up this old gem: A YouTube clip of Tay Zonday standing in Loring Park talking about how the history of Minneapolis's transit system informs his decision to drive a car rather than walk. Tay holds a small audience captive with his oral history lesson -- that is until a man in the background has an inchworm fall on his shoulder, stealing the attention of the person filming.
Random and strange. Oh, internet!
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text:
- Capsules: 100, 300, and 400 mg.
- Tablets: 100, 300, 400, 600, and 800 mg.
- Solution: 250 mg/5 ml
The recommended dose for postherpetic neuralgia is 1800 mg daily in 3 divided doses (Neurontin) or 1800 mg once daily (Gralise). Gralise is not interchangeable with other gabapentin products. Seizures are treated with 900-1800 mg/daily in 3 divided doses (Neurontin). Withdrawal of treatment should occur slowly over a week.
DRUG INTERACTIONS: Antacids reduce the concentration of gabapentin in blood. Therefore, gabapentin should be administered 2 hours or more after taking antacids. Morphine significantly increases blood concentrations of gabapentin and may increase central nervous system-related adverse events associated with gabapentin.
PREGNANCY AND BREASTFEEDING SAFETY: Safety in pregnancy has not been established.
Gabapentin is secreted in human breast milk. Nursing mothers should only use gabapentin if the benefits outweigh the unknown risk to the fetus.
STORAGE: Tablets and capsules should be stored between 15 C to 30 C (59 F to 86 F). Gabapentin solution should be refrigerated between 2 C to 8 C (36 F to 46 F).
DOSING: Gabapentin may be taken with or without food.
DRUG CLASS AND MECHANISM: Gabapentin is an anti-sizure (anti-convulsant) drug that is used for preventing seizures and for treating post-herpetic neuralgia, the pain that follows an episode of shingles. The mechanism of action of gabapentin is not known. Gabapentin structurally resembles the neurotransmitter gamma aminobutyric acid (GABA). (Neurotransmitters are drugs that nerves use to communicate with one another.) It is possible that this similarity is related to gabapentin's mechanism of action. In animal models used for testing the anticonvulsant and analgesic (anti-pain) activities of drugs, gabapentin prevents seizures and reduces pain-related responses. The FDA approved gabapentin in December 1993.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information
Quick GuideEpilepsy: Symptoms, Causes and Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Original Article
Contrasting reproductive traits in two species of mangrove-dwelling littorinid snails in a seasonal tropical habitat
Version of Record online: 27 JUL 2012
DOI: 10.1111/j.1744-7410.2012.00269.x
© 2012, The American Microscopical Society, Inc.
Invertebrate Biology
Volume 131, Issue 3, pages 177–186, September 2012
Additional Information
How to Cite
Ng, T. P. T. and Williams, G. A. (2012), Contrasting reproductive traits in two species of mangrove-dwelling littorinid snails in a seasonal tropical habitat. Invertebrate Biology, 131: 177–186. doi: 10.1111/j.1744-7410.2012.00269.x
Publication History
- Issue online: 4 SEP 2012
- Version of Record online: 27 JUL 2012
Funded by
- Abstract
- Article
- References
- Cited By
- Littoraria ;
- reproduction;
- size-assortative mating;
- spawning
Previous studies on the reproductive biology of littorinid snails have focused on rocky shore species, investigating how these gastropods can achieve maximal reproductive success, as well as on processes of sexual selection. This study documented differences in the reproductive traits of two mangrove-dwelling littorinids, Littoraria ardouiniana and L. melanostoma, in Hong Kong. Reproductive activity of both species was most intense during the summer months. Mating pairs of the two species generally occurred in the tree canopies. Few false mating pairs (same sex or heterospecific pairs: <10%) were recorded, and members of both species showed size-assortative mating. Littoraria ardouiniana had a shorter reproductive season but a higher intensity of mating and higher seasonal fecundity, than did L. melanostoma. Members of both species showed bi-lunar periodicities of egg or larval release, synchronized with spring tides. Fecundity showed a strong positive relationship with body size in L. ardouiniana, but not in L. melanostoma. Females of L. ardouiniana released entire broods of larvae in a single brief event, whereas females of L. melanostoma released fewer eggs over 1–8 d. Release of larvae in L. ardouiniana involved a series of short bursts and was much faster than the trickle release of eggs in L. melanostoma. The contrasting reproductive traits in these two species represent different strategies to optimize reproductive success in mangrove habitats.


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Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis.
Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1g/L) or those with ACR in the macroalbuminuric range (≥30mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2mg/mmol for males and ≥2.8mg/mmol for females. Other measures included fasting glucose, haemoglobin A1c, triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences.
Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p=0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p=0.03], increasing systolic blood pressure [p=0.009], and increasing body mass index (BMI) [p=0.04].
The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD.
The incidence of end-stage renal disease (ESRD) among Canadian First Nations people is 2.5-4 times greater than among the non-First Nations population [1-3] and the most common cause is diabetic nephropathy. The earliest indicator of diabetic renal disease is microalbuminuria [4-10], which appears 5-10years prior to the onset of overt proteinuria. Proteinuria is a sign of more advanced renal disease and is a precursor to renal failure [11]. Importantly, albuminuria is a strong and independent predictor of cardiovascular and all cause mortality [12]. Additionally, the impact of renal disease on health care costs and quality of life for patients and their caregivers is substantial [13-16]. Blood pressure and glucose control among those with diabetes and/or chronic kidney disease, with either medication and/or lifestyle changes have shown to be effective in preventing progression to advanced renal disease [17-19]. Therefore screening for albuminuria in high risk populations may be one component of an effective community-based renal disease prevention strategy.
While the excess burden of diabetes among First Nations populations compared to the general Canadian population is well established [20], research on diabetes-related kidney disease among Canadian First Nations populations is more limited. A retrospective population-based study from Saskatchewan for the years 1981-90 revealed that among those with diabetes, the rate of ESRD in First Nation people was 7 times greater than among non-First Nation people [2]. The prevalence of microalbuminuria among a sample of 601 First Nation residents in northern Saskatchewan was 24% among those with diabetes, and 9% among those without [21]. Non-diabetic diseases, such as glomerulonephritis, that can lead to ESRD and which can present with albuminuria and hematuria are also significantly increased in First Nation people [3]. According to the Canadian Diabetes Association Clinical Practice Guidelines, First Nations adults with at least one risk factor should be screened for diabetes every 1-2years and those with type 2 diabetes should be screened for albuminuria at diagnosis and annually thereafter [22]. Despite these recommendations and the increased burden of diabetic and non-diabetic renal disease, few population-based screening studies for albuminuria among Canadian First Nation populations have been performed. The study community reported in this article has a high prevalence of ESRD (5%), diabetes (29%) and impaired fasting glucose (7%) [23]. Thus, the community is at high risk for diabetic renal complications. Therefore the purpose of this paper is to determine the prevalence and determinants of albuminuria in a Canadian First Nation population, and to begin planning for secondary prevention strategies.
The data for this paper are from a previously described larger screening study for diabetes and diabetes complications [23] conducted in 2003 among adult members of the Sandy Bay First Nation, located about 200km northwest of Winnipeg, Manitoba, Canada, with year round road access. Its population in December 2001 was 2,968, of which 52% were under the age of 18. Inclusion criteria were: non-pregnant, community member, and 18years and older. A total of 483 community members participated; 36% of all eligible adults (n=1356). That is, there were 1356 eligible adults in the community, according to the inclusion criteria, and 483 chose to participate. Estimates of albuminuria were obtained on the 468 participants who had completed all components of the study, which included anthropometrics (height, weight, and waist and hip circumferences); a demographic and health status questionnaire; fasting blood samples for glucose, A1c,and lipids; and random urine sample. Although albuminuria is not the best clinical tool to identify kidney disease, for an epidemiological screening study, albuminuria is an excellent predictor for ESRD, CVD, and all-cause mortality [12]. This study was approved by the Health Research Ethics Board at the University of Manitoba.
Urine albumin:creatinine ratio (ACR) was determined using the Bayer® DCA 2000™ Point-of-Care Analyzer, which is highly accurate and reproducible [24,25]. Each urine sample was first tested by a Multistix Reagent strips for presence of protein, and blood. Participants' whose samples tested "trace or more" for blood or≥1g/L protein were requested to return on another day. Samples negative for blood and protein were loaded into the DCA 2000™. Microalbuminuria was defined as no positive dipstick reading for protein and at least one test with ACR >2.8mg/mmol for women and >2.0mg/mmol for men. Individuals with dipstick positive proteinuria (>1g/L) or those with ACR in the macroalbuminuria of proteinuria range (≥30mg/mmol) on at least one sample were considered to have proteinuria. A maximum of three samples were obtained.
Venous samples for glucose, were drawn after an overnight 12-hour fast. Participants with fasting glucose values ≥5.8mmol/L were requested to return for a second sample; the average of the two samples was used in analysis. Diabetes was defined as a fasting blood glucose ≥7.0mmol/L. Impaired fasting glucose was defined as fasting blood glucose of 6.1-6.9mmol/L, as per the Canadian Diabetes Association [26]. Samples were analyzed at the Clinical Chemistry Lab at the Health Sciences Centre, Winnipeg, Manitoba.
Blood pressure was measured on site by a registered nurse or a trained research assistant, working under the supervision of the registered nurse. The average of two readings was used. Hypertension was defined as a blood pressure >140/90mm Hg for those without diabetes, ≥130/80mm Hg for those with diabetes and/or albuminuria, according to the American Diabetes Association [27,28], or a previous diagnosis treated with medication. Anthropometric measures including height, weight, and waist and hip circumferences were completed using standard techniques [29]. Current and past smoking status and number of cigarettes smoked per day were determined using a standardized questionnaire. Pack years was calculated as number of packs per day (1 pack=20 cigarettes) multiplied by number of years smoked. Standard demographic information and diabetes history were derived via questionnaire. Awareness of disease states by participant, such as diabetes, hypertension and kidney disease, was asked by a simple direct question in similar fashion to the NHANES III study cohort [30].
Data are presented as mean (standard deviation) for continuous variables, median (range) for continuous variables that do not follow a normal distribution, and as n (percent) for categorical variables. Demographic, anthropometric and health characteristics were compared using t-tests for normally distributed continuous variables, χ2 tests for categorical variables and Mann–Whitney U non-parametric tests for non-normally distributed continuous variables. Univariate and multiple logistic regression (backwards stepwise) were used to determine associations with albuminuria. Continuous variables were also explored as categorical variables to determine appropriateness of assumptions of linearity. Those variables that were found to be significant in univariate analysis, as well as independent of age, were included as potential variables in the backwards stepwise logistic regression model. Tests were two-tailed with p<0.05 considered significant. Statistical analyses were performed using SPSS (version 16).
The study sample was representative of the larger community for age, sex, education and employment status [23]. That is, the sample had similar proportions of the previously listed characteristics as the study population. Nine subjects were ineligible due to incomplete data and 6 were excluded from the albuminuria analysis due to persistent hematuria, leaving 468 subjects for albuminuria analysis. Participants with persistent hematuria were excluded due to the inability to obtain an ACR and we could not determine the cause of the hematuria. These individuals were referred for clinical evaluation. However, most individuals whose first test was positive for hematuria were found not to be hematuric on subsequent tests and were included in analysis. The majority of these participants were women who were tested close to their menstrual period.
Demographic and health risk characteristics of the study population are described in Table Table1.1. Both sexes were equally represented. The population was young and the mean age was similar for men and women (37 for men; 38 for women). Less than half the study sample had completed grade 9. The study population had high rates of cardiovascular risk factors; three-quarters of participants were current smokers, 43% had hypertension, 35% had diabetes or prediabetes and obesity was highly prevalent.
Twenty-five percent of the sample returned for at least a second random urine test (Table (Table2).2). However, of those who had abnormal samples (ie. hematuria or proteinuria) on their first test, 79% returned for a second or third test. Albuminuria was present in 95/468 or 20% of participants. Twenty-five participants (5%) had proteinuria and 70 (15%) had microalbuminuria. In univariate analysis [OR (95% CI) p-value], age [1.039 (1.008, 1.072) p=0.014], diabetes [11.474 (4.209, 31.279) p<0.001], systolic blood pressure [1.039 (1.019, 1.061) p<0.001], diastolic blood pressure [1.051 (1.018, 1.086) p=0.002], fasting glucose [1.257 (1.155, 1.367) p<0.001] and hypertension [4.390 (1.709, 11.277) p=0.002] were associated with proteinuria. There was a non-significant trend for lower odds of proteinuria among females [0.428 (0.181, 1.012) p=0.053]. BMI, ever smoker, and years diagnosed with diabetes were not associated with proteinuria. For all other analysis, those with proteinuria and microalbuminuria were combined for analysis due to small numbers and equivalence on the following characteristics: age, sex, smoking status and mean years smoked. However, the proportion of those with diabetes was greater among the proteinuria group compared to the microalbuminuria group. Eighty percent (20/25) of those with proteinuria had diabetes.
Participants with and without albuminuria are compared in Table Table3.3. Those with albuminuria were older (p<0.001) and albuminuria prevalence progressively increased with age (Figure (Figure1).1). Men were more likely to have albuminuria than women (p=0.01). Interestingly, those with albuminuria were less likely to report ever having smoked (p=0.007). However, neither years of smoking nor pack-years smoked were significantly different between groups. Participants with albuminuria were more likely to be hypertensive by any measure. Seventy percent (70%) of those with albuminuria had hypertension compared with 36% of those without albuminuria (p<0.0001). In this regard, mean blood pressures were significantly higher in the group with albuminuria compared to those without. Target blood pressure in those with albuminuria is generally recommended to be <130/80mm Hg, however, this was achieved in only 34% of those with albuminuria.
Participants with albuminuria were significantly heavier and had a higher BMI (Figure (Figure2).2). This increased weight and BMI may be related to the greater proportion of participants in the albuminuric group with diabetes and impaired fasting glucose. Fasting glucose was also higher among those with albuminuria compared to those without (p<0.001). While almost 60% of those with any degree of albuminuria had diabetes, 42% of those with diabetes were albuminuric.
Odds ratios and 95% CI are listed in Table Table44 for both univariate and multivariate logistic regression. Backwards stepwise multivariate logistic regression was performed. Univariate analysis indicated the odds of having microalbuminuria increased 4% for each year increase in age. However, age was not significant in the final multivariate model. When both fasting glucose and years of diabetes were removed from the model and age was included, age became significant suggesting high multicolinearity between the diabetes and age (model not shown). Females were less likely to have microalbuminuria than males, which remained significant in the multivariate model. Smokers were less likely to have albuminuria than non-smokers and while smoking appeared protective in univariate analysis, it did not achieve significance in the multivariate model.
Those with diabetes were seven times more likely to have albuminuria than those without diabetes. In addition, for each mmol/L increase in average fasting glucose, albuminuria increased by 27% in the univariate model, and 20% when controlling for sex, years diagnosed with diabetes, systolic blood pressure and BMI. Length of time with diabetes was also a significant predictor of albuminuria and confirms the natural history of diabetic nephropathy. Systolic blood pressure was independently associated with albuminuria in the multivariate model and risk of albuminuria increased by 2% for every mm Hg increase in systolic blood pressure. Lastly, weight and BMI were both significant alone, but BMI was an independent predictor of albuminuria in the multivariate analysis, after accounting for average fasting glucose, gender, years diagnosed with diabetes mellitus and systolic blood pressure [1.042 (1.001, 1.085), p=0.04].
In contrast to participants with diabetes and hypertension, very few with albuminuria were aware of their condition. Participant awareness of kidney disease increased with severity such that 17% of those with proteinuria were aware of kidney disease while awareness kidney disease in those with microalbuminuria was only 1% (Table (Table11).
High prevalence of diabetes and renal complications of diabetes (ESRD) have been previously described among Canadian First Nations people [1,2,31-33]. Significant rates of renal complications (ESRD) among non-diabetic First Nations people are also seen [3,34]. Microalbuminuria is well recognized as a significant precursor to either diabetic or non-diabetic renal disease, and has been described in both those with and without diabetes. In the current population-based study, albuminuria rates of 20% among the total population were as high as among other high-risk populations such as the Pima in the southwestern United States [4,7,35]. Among those with diabetes in our study, 42% had albuminuria, which is substantially greater than the prevalence among the general US population (28.8%) as described in the NHANES III study [36], and the 24% estimated in a Canadian First Nation population-based study in Saskatchewan [21]. The present study prevalence is comparable to the American Pima and Zuni populations in which 47% and 52% of the diabetic population, respectively, had albuminuria [7,15].
The current study found female gender protective for albuminuria, independent of fasting glucose, years with diabetes, systolic blood pressure or BMI. This association was also found in the Strong Heart Study [37]. This contrasts with the NHANES III and Pima Indian non-diabetic data, in which women had significantly more albuminuria than men [7,36]. The NHANES III study, however, did not use the lower cut-off for ACR in males, as did the current study. A different ACR cut-off due to higher excreted creatinine in males has been supported by many investigators and is supported by the Canadian Diabetes Association Clinical Practice Guidelines [26,38-40], and may account for the differences between the NHANES and Pima Indian non-diabetic data and the current study. Furthermore, in the Pima diabetic population and the Zuni Indian population studies, no sex differences were seen [4,7,35]. Mortality rates among men with albuminuria tend to be higher than in women [41], and therefore the increased albuminuria among men in our study is concerning.
BMI was also independently related to increased prevalence of albuminuria in the study sample. Although increased BMI has been described as a risk factor for albuminuria and proteinuria [42] and high BMI is an issue among those of First Nations ancestry [43-45], to our knowledge, BMI has not been previously described as an independent risk factor for microalbuminuria in the Canadian First Nations population.
While age has been found to be significantly associated with albuminuria [36], age was not included in our final multivariate model, likely due to high multicolinearity with duration of diabetes and diabetes itself. However, the average age of those with albuminuria increased by glycemic status (i.e., non-diabetes, IFG and diabetes). While by no means confirmatory, this suggests a possible difference in lead time. As albuminuria is a risk factor for diabetes [46], those younger individuals with dysglycemia and even without diabetes, may develop diabetes as they age.
Participant awareness of kidney disease in a First Nation community is reported here for the first time. Awareness of kidney disease within the study population was low compared to other disease states such as diabetes and hypertension. Awareness of kidney disease was also lower than that found among the general U.S. population where 24% of participants reported being aware of their kidney disease [29]. Disease awareness is related to many factors at both the individual and systems levels. At the individual level, reported awareness of disease can be limited by patient understanding and denial; that is, although care providers may inform patients of their illness, patients may not integrate that information. Another factor affecting awareness is lack of screening or diagnostic testing on the part of health care providers, thereby preventing detection. At the systems level, access to physicians on the part of patients and suitable practice environments for physicians (i.e., access to and remuneration for diagnostic testing) can either enable or act as barriers to preventive practice. Factors influencing poor disease awareness among our study population could not be determined. Thus, further research is required to address the lower than anticipated awareness in this high-risk population.
The study is subject to limitations. The sample size is limited and was not randomly selected from the eligible population. However, our sample was representative of the eligible study population on demographic factors (i.e., age, sex, employment, education) and, as previously reported [23], was not over-represented by the ill or infirmed. In fact, only 38% of those known to have diabetes at the start of the study were participants. In addition, only three out of 10 individuals with previous amputations participated in the study, and none of the 15 individuals with ESRD participated. Therefore, we are confident that our sample represents the larger community. However, the results may not be generalizable beyond the study population because we are not able to determine if the study population is representative of First Nations communities across Canada. Furthermore, the lack of availability of serum creatinine to further indicate severity of renal dysfunction is also a limitation. Lastly, those participants that had a normal ACR did not complete repeat testing.
Albuminuria is an important complication of diabetes and a risk factor for ESRD and cardiovascular disease. Identification of relevant risk factors is therefore an important activity that can assist in the development of targeted prevention efforts. Interestingly, we found the presence of significant numbers of people with microalbuminuria and hematuria without other risk factors, confirming the presence of non-diabetic renal disease. Further investigations should be focused on this group; first to help ascertain the cause of their hematuria or albuminuria, and second to intervene appropriately. Lack of awareness of early renal disease among study participants is a concern and efforts to understand the phenomenon and improve awareness will be undertaken in partnership with the community. Ongoing longitudinal follow-up of the individuals in this study would further our understanding of the significance of individual health determinants. In addition, further follow-up would give important information about the natural history of albuminuria in this population. The response to treatment and community intervention strategies could also be assessed.
ACE: Angiotensin-converting enzyme; ACR: Albumin-creatinine ratio; ARB: Angiotensin receptor blocker; BMI: Body mass index; ESRD: End-stage renal disease.
The authors declare that they have no competing interests.
JZ conducted data analysis, interpretation, and preparation of the manuscript. KY is the principal investigator and was involved in the conception and design of the study, analysis and has reviewed this manuscript for intellectual content. NDR assisted in data analysis and preparation of the manuscript for publication. JR is the Director of the health centre in the community and was involved in the conception and design of the study. SB contributed to the conception and design of the study as well as acquisition of the data, analysis and preparation of the manuscript. All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
We would like to thank the Canadian Institute for Health Research (CIHR -TKY) and the Manitoba Health Research Council (SGB) for their funding. NDR is funded by a CIHR Frederick Banting and Charles Best Canada Graduate Scholarship. Finally, we gratefully acknowledge the study community, staff and leadership for their participation and on-going commitment.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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1163 posts tagged with recipes.
Displaying 301 through 350 of 1163. Subscribe:
Cooking my way around India
I want is to be able to start generating a variety of curries with the ingredients I have to hand, and have them be slightly more authentic than the old apple-sultana-coconut-yoghurt-and-contents-of-spice-rack 1970s British curry knockoff. Is there an internet resource somewhere with the Westerner's Introductory Taxonomy of Regional Indian Cooking? [more inside]
Meat 101
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These peanut butter T-rexes are underwhelming.
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Jimmy Dean?
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Recipe & shopping list app for Android
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Delicatessen for Dilettantes & Greenhorn Cuisine
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Deep dish is to Chicago as ______ is to San Francisco?
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Pressure Cooker Recipes
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How to use up peanut butter?
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Fish dish
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Delicious "no-cook" dishes in under 30 min?
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Brunch: My Favorite Team Sport
I am having a New Year's Day brunch and I'd like to serve some fancy things that aren't typically homemade here in the US. [more inside]
Fingerfood dessert recipe using frozen strawberries?
I have been freezing strawberries from my garden and currently have about 6-8 cups of them. I need to take a dessert to a Christmas party this weekend. I would like to use the strawberries, but it needs to be something that can be eaten with fingers (probably no bowls or utensils will be available) and work well with berries that have been frozen. Any ideas?
Dishes similar to sautéd chanterelles?
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Please help me brainstorm around this flurry of snowflakey meal requirements
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Cookies that freeze?
I love to bake cookies for the holidays. I'd like to do most of my baking the second weekend of December (8 & 9), but that's earlier than I've done my baking in the past. Do you have recipes for cookies that freeze well? Preferably after baking? [more inside]
Simple recipes caught on video.
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Overthinking a plate of turkey
We decided to do turkey parts this year, instead of a whole bird, and could only find a boneless skinless turkey breast for the white meat portion of our Thanksgiving meal. How do we cook it? [more inside]
We need to have the best sweet potatoes for Thanksgiving.
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Delicious one-pot meals for busy people?
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Help me help her help him!
Tonsillectomyfilter: What are some soft foods that contain no fruit, corn syrup, or dairy and taste all right at room temperature? [more inside]
Switching it up with salmon filets
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Sauces/seasonings for rice and beans?
My lunchtime staple is a bowl of black/kidney/pinto beans or lentils and brown/white rice, couscous, or quinoa with some type of vegetable mixed in. However, I get bored with the same sauces and seasonings (usually barbecue sauce, peanut sauce, salsa, or just plain with some onion and garlic) and am looking for new ideas. Must be vegetarian (dairy and eggs okay) and bonus points for *cheap* store bought sauces/dressings or homemade from ingredients I might already have in the pantry. I'm not a picky eater and am not concerned with fat/calories.
tired of roast chicken
tired of roast chicken! Give me recipes and meal ideas are: elegant ( you would serve it at a fancy dinner party), winter seaonal foods, intensely flavorful, beautiful, whole food ingredient based (ie probably no tins of condensed soup), have that wow factor that impresses guests, and bonus (but not super important) are 'paleo'.
Will carbonnade a la flamande be good in the crockpot?
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Make Food Now Dot Com
Does such a recipe website exist? [more inside]
Help me find recipes that are interesting to eat with your eyes closed.
I want to treat my girlfriend to an unusual dinner. [more inside]
Help me recreate this dish!
At a restaurant I had an amazing dish with the following description, "vegetarian black bean chili, seasoned rice and steamed vegetables." It was spicy and I loved it, but couldn't describe it beyond being traditional American, perhaps a bit with a Mexican flavor. This seems like a really simple dish, any ideas of dishes like it or how to recreate it?
Insert recipe suggestions here!
Recipe suggestions for chaotic new family lifestyle with a number of dietary restrictions. [more inside]
Ideas for Vampire Dinner Party
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Help me find cold vegan foods.
I'm doing the Eat to Live diet, which is basically vegan, and am having trouble coming up with interesting ways to prepare green vegetables so they taste good cold. [more inside]
Salad ain't cutting it, I want protein!
I commute by bike, and ever since my commute tripled in distance, I've been coming home tired and hungry and and wanting to EAT ALL THE PROTEIN. Can you recommend some tasty, high protein vegetarian or pescetarian meals which I can either prepare in advance or throw together in the 20 or so minutes before severe post-workout hungry-crankiness sets in? [more inside]
Long shortcuts
Tell me your recipes that get much easier with a little bit of advance planning! I like cold-brew coffee and this recipe for hash browns, not just because they're tasty, but because they're less work than regular coffee or hash browns, as long as I remember to do a tiny bit of preparation the night before. What else is like that? (If you have some non-food tips that fit the theme, that's good too...)
Tamarinds and lemons say the bells of near south Minneapolis
Give me your recipes containing lime! Or lemon or tamarind! Certain restrictions may apply. [more inside]
I'd rather starve!
How can I make my healthy meals taste less, well...healthy? [more inside]
Recipes for rib eyes that aren't in steak format?
Recipes for rib eyes that aren't in steak format? [more inside]