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Coeur d'Alene: Great Place To Retire
It was 15 years ago that Nola Lagg's son brought her from Florida to Coeur d'Alene, she recalled, because of an illness she was facing. She grew rather attached to the place. "I never went back," the 85-year-old said with a chuckle on Thursday, while eating with friends at the Lake City Center. Although the winters took getting used to, she said she has still preferred her retirement years in Coeur d'Alene, where shopping, beautiful scenery and delicious eateries are abundant. "I've been to them all," Lagg said of restaurants she toured with her son. She even prefers the clouds. "In Florida, they're flat and boring," Lagg said. "Here, they're big and puffy. I'm absolutely fascinated with the clouds." Take a back seat, Miami. Arizona? Forget it. CNN Money has just given Coeur d'Alene some publicity it doesn't seem to need/Alecia Warren, Coeur d'Alene Press. More here.
Question: Why aren't winters in the Inland Northwest a deal-breaker for retirees seeking to relocate?
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"Fight until there's nothing left. Fight until you're dying breath." - "Fight" by someonElse
These lyrics off their new album "rEvolution: The Summoning Wars Part 1" speak of perseverance, a term someonElse knows all too well. No matter what obstacles lay in your path (or if there's nothing left), you must always fight and keep pushing forward.
Imagine if you will that the year is 2011. SomeonElse takes on all responsibility for recording, editing and mastering their debut album "The Doomed" in a full DIY fashion. Their strong DIY work-ethic and mentality shines through with the release along with a diverse influence of varying hard rock and metal styles. The album gains many positive reviews from around the globe and earns them a strong following which leads to sold out shows at such venues as Mercury Lounge, Highline Ballroom, Irving Plaza, and a successful run of shows in Puerto Rico.
Fast forward to October 2013 and the band releases their second album "Still Doomed: Remixes, Alternate Versions, and Other Garbage" which is an 18-track remix album of "the Doomed". The release showcases them as an eclectic musical group with EDM, industrial and hip hop influences throughout the album. This also solidifies their reputation as a surprising, and diverse, entity in the hard rock/metal scene.
Now here we are, with bassist Thomas G. (Eve To Adam, former Jim Rose Circus member) joining the fold just in time to begin working on their third album. "rEvolution" is their greatest pride and joy; capturing their ever growing imagination and range of influences while once again handling all recording and editing on their own in the band's home base of Long Island City, NYC. The entirety of the album was recorded live, to bring out the best of each musicians performance. To top it off, mastering duties were handled by Joey Z. (Life of Agony, Stereomud) which in turn pushed the album's sonic landscape beyond the bands expectations
With the release of "rEvolution: The Summoning Wars Pt. 1" in Spring of 2015, Perseverance holds new meaning to the band, as someonElse are poised to leave a lasting mark on the hard rock and metal scene as we know it.

subset: commoncrawl


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BREAKING: Obama just ate a Jucy Lucy; press secretary reports it was "delicious"
Mark your calendars, Minnesota: June 26, 2014, is officially the day our commander-in-chief bit into the food of the gods we call the Jucy Lucy.
Spotted at Matt's Bar enjoying the Twin Cities' classic cheese-stuffed burger, President Barack Obama may have just escalated the cold war between Matt's and the 5-8 Club.
See also:
Where should Obama go while he's in Minneapolis?
The POTUS is in Minneapolis through Friday, where he'll give a speech about the economy at Lake Harriet Bandshell. Today he attended a Minnehaha Park town hall meeting and met a Minnesota mother, Rebekah Erler, who had written a letter to him explaining the woes of the nation's middle class earlier this year.
Just enjoyed a "Jucy Lucy" [sic] at Matt's Bar. Delicious. Potus enjoyed his too. Now, the town hall at Minnehaha Park is abt to start.
-- Josh Earnest (@PressSec) June 26, 2014
Since Obama's Jucy Lucy became official, we've been plagued with burning questions. Will the president ever go back to boring cheese-on-top burgers again? Will the Jucy Lucy make its way onto our flag? Will the 5-8 Club be given its day of presidential rebuttal? Will Obama survive this town hall meeting with a food coma of such proportions?
The people deserve to know.
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BEST BETS: "Jessica Jones," "Big Trouble/Escape from New York" & More October 2016 Highlights
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Jul 27, 03:02am
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Exeter, UK
Matt Lanter has just been cast in a new time travel drama at NBC from "Supernatural" and "The Shield" creators Eric Kripke and Shawn Ryan. The show is currently called "Time," and is said to be a mashup of "Back to the Future" and "Mission Impossible."
Lanter, who voiced Anakin Skywalker in "Star Wars: The Clone Wars," and Harry Osborn in "Ultimate Spider-Man," joins previously cast Abigail Spencer ("Suits," "Cowboys and Aliens.")
According to Deadline, who broke the news of Lanter's casting, "Time" will be a "high-octane drama following an unlikely trio who travel through time to battle a master criminal intent on altering the fabric of human history with potentially catastrophic results."
"Time" is currently in the pilot phase, and if it gets picked up, will likely air in the fall.
The description sounds like a watered down version of DCs Legends of Tommorow
I don't think that show can be watered down even more.
Then we'll see when this one pops on the TV :D
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Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal similar to humans with OCD-spectrum disorder trichotillomania. Since Hox gene disruption often has pleiotropic effects, the root cause of this behavioral deficit was unclear. Here we report that, in the brain, Hoxb8 cell lineage exclusively labels bone marrow-derived microglia. Further, this pathological behavior is rescued by transplantation with wild-type bone marrow. It has been suggested that the grooming dysfunction results from a nociceptive defect, also exhibited by Hoxb8 mutant mice. However, bone marrow transplantation does not rescue the sensory defect. Also, disruption of Hoxb8 in the hematopoietic lineage recapitulates pathological grooming, without conferring nociceptive insensitivity. Conversely, disruption of Hoxb8 in the spinal cord, results in generating the sensory defects, without induction of pathological grooming. Immunological dysfunctions have been associated with neuropsychiatric disorders but the causative relationships are unclear. In this mouse, a distinct compulsive behavioral disorder is associated with mutant microglia.
Grooming in mammals is an innate, stereotypic behavior with a well defined syntax (Berridge et al., 1987). The head is invariably groomed first, followed by body regions and finally the anogenital region and tail. This cephalocaudal progression of grooming is defined as the "syntactic groom chain". Previous studies have shown that multiple regions of the rodent brain, notably the brainstem, striatum and cortex are used to implement the syntactic groom chain (Aldridge, 1993; Berridge, 1989; Berridge and Whishaw, 1992).
Mice homozygous for a loss of function mutation in Hoxb8 show excessive grooming. The syntax of grooming appears normal, but the number of incidences per unit time and the duration of grooming bouts are increased (Greer and Capecchi, 2002). However, the behavior is pathological, for it leads to hair removal and self-inflicted open skin lesions at the over groomed sites. This behavior is very similar to that described for humans with the OCD-spectrum disorder, trichotillomania, where compulsive removal of hair is also a hallmark. This disorder is quite common in humans with an occurrence ranging from 1.9-2.5 per 100 in seven separate international communities (Horwath and Weissman, 2000). Curiously, these mutant mice also excessively groom their wild type cage mates. This aspect of the phenotype suggested that the peripheral nervous system is not likely responsible for the excessive grooming behavior (Greer and Capecchi, 2002).
Hoxb8 mutant mice also show altered response to nociceptive and thermal stimuli, which have been attributed to deficiencies in the formation and organization of interneurons in the dorsal spinal cord laminae I and II that receive the majority of nociceptive inputs (Holstege et al., 2008). Holstege, et al. further suggested that the excessive and pathological grooming defects previously described in Hoxb8 mutants result from to these sensory spinal cord defects.
It was quite unexpected that disruption of a Hox gene should result in a distinct behavioral deficit such as excessive and pathological grooming (Greer and Capecchi, 2002). Hox genes are normally involved in establishing body plans by providing positional values along the major axes of the embryo (Capecchi, 1997). However, Hox genes also have direct roles in the formation of multiple tissues and organs, including the formation of the hematopoietic system, and, with respect to Hoxb8, maintenance and differentiation of myeloid progenitor cells, one of the two known sources of microglia (Kawasaki and Taira, 2004; Krishnaraju et al., 1997; Perkins and Cory, 1993).
Since implementation of grooming in rodents is rooted within the brain, we anticipated that Hoxb8 would be expressed in a neural circuit that modulates grooming behavior. Instead we have surprisingly found that, in the brain, the site that generates and implements grooming behavior, the only detectable cells derived from Hoxb8 cell lineage are microglia. Secondly, we demonstrate that normal bone marrow transplantation into lethally irradiated Hoxb8 mutant mice rescues the excessive pathological grooming behavior, without correcting the spinal cord defects. Thirdly, conditional restriction of Hoxb8 deletion to the hematopoietic system results in mice with the excessive grooming and hair removal behavioral defects, without induction of the nociceptive/spinal cord defects. Finally and conversely, conditional deletion of Hoxb8 in the spinal cord, generates mice with the spinal cord sensory defects, but with normal grooming behavior.
These experiments strongly support the hypothesis that the excessive pathological grooming behavior observed in Hoxb8 mutant mice originates from defective microglia, thus directly connecting hematopoietic function to mouse behavior. The extensive role of microglia, as the brain's monitor and responder of immune activity, in the normal function of our brain is becoming increasingly apparent. As examples, immunological dysfunctions have been widely linked to many psychiatric disorders including obsessive compulsive disorder (OCD), major depression, bipolar disorder, autism, schizophrenia, and Alzheimer disease (Ashwood et al., 2006; da Rocha et al., 2008; Kronfol and Remick, 2000; Lang et al., 2007; Leonard and Myint, 2009; Strous and Shoenfeld, 2006). In addition, results from genome wide association studies suggest that genes whose dysfunction have been implicated in immune dysfunction and/or signaling, contribute to increased susceptibility to the above mentioned mental disorders (Hounie et al., 2008; Purcell et al., 2009; Shi et al., 2009; Stefansson et al., 2009).
Unfortunately, animal models that directly associate distinct behavioral deficits with defective microglia have been lacking. Here we provide such a model which should allow interrogation, at the molecular genetic and cellular levels, the roles of microglia in promoting normal behavior and how perturbation of microglia leads to pathological behavior.
Hoxb8 mutant behavior is characterized by excessive pathological grooming. Previously, we determined the number and duration of grooming bouts from continuous video recording of mouse activity (Greer and Capecchi, 2002). This procedure was robust, but very labor intensive. More recently, we have been using technology developed by B. V. Metris based on the use of very sensitive vibration detectors (Laboras platforms). Each activity such as drinking, eating, rearing, climbing, locomotion, immobility, grooming and scratching is associated with characteristic patterns of vibration, which are continuously recorded. A computer algorithm then interprets specific vibration patterns as individual behaviors. The advantage of this approach is that behavior is classified automatically, and collected non-obtrusively, over any chosen period of time. We typically monitor activity over 24-hour periods. We have evaluated the Laboras platforms for their assessment of time spent grooming by co-monitoring mouse activity using our video camera system. The Laboras platforms are remarkably accurate, comparable to human classification and far less labor intensive. Supplemental Figure S1A shows the average time spent grooming for 25 Hoxb8 mutant mice and 22 controls over 24-hour periods as measured by the Laboras platforms. These results compare very well with those previously obtained by analyzing continuous video recordings, illustrating that on average Hoxb8 mutant mice spend approximately twice as much time grooming as their wild-type littermates (Greer and Capecchi, 2002). The penetrance for excessive grooming in Hoxb8 mutant mice is 100%.
The expression pattern of Hoxb8 in the adult brain is broad (Greer and Capecchi, 2002). However, the expression level is very low and dispersed in the brain making it difficult to identify the cell type(s) expressing Hoxb8. To identify the Hoxb8 cell lineage in the mouse brain, we generated a Hoxb8-IRESCre driver that could be used to activate Cre dependent LacZ or YFP reporter genes targeted to the ubiquitously expressed ROSA26 locus (supplemental Figure S1B; Soriano, 1999). In mice carrying both the Hoxb8-ICre driver and ROSA26-YFP reporter alleles, activation of Hoxb8 expression also triggers YFP production. Brains of such mice were collected at pre and post-natal stages and examined by immunohistochemistry. In adult brains, YFP positive cells can be found throughout the brain, but consistent with previous results, predominantly in the cerebral cortex, striatum, olfactory bulb and brainstem (data not shown). These cells appear morphologically to be microglia and indeed co-express the general microglia marker CD11b and Iba1, a marker of activated microglia (Figures 1 A-C and data not shown) indicating that Hoxb8 is expressed in microglia or their progenitor cells. Notably, not all microglia in the brain are YFP positive, suggesting that Hoxb8 expression was present only in a subpopulation of microglia or their progenitors (~40% of total, see Figure 7C).
In newborn mice, very few Hoxb8-labeled cells are observed in the brain, and these cells are found predominantly in the choroid plexus (Figure 1D), meninges, and the ventricular lining, with their numbers declining with increased distance from the ventricular zone. This gradient suggests migration of YFP positive cells from the ventricular zone into the forebrain areas. Between P2 and P14, YFP positive cell count in the mouse brain increases dramatically and is then maintained at this high level (Figures 1E-F and data not shown).
Although the origin of microglia is still debated, there is general agreement that at least one subpopulation is of bone marrow origin, [i.e. derived from circulating monocytes; (Kaur et al., 2001; Ransohoff and Perry, 2009)]. The time of first appearance and the site of entry of Hoxb8-labeled microglia is consistent with this subpopulation being of hematopoietic, bone marrow-derived origin.
To assess if the Hoxb8 mutation affects the number of microglia present in the adult brain, comparable sections of the brain were evaluated for the presence of Iba1 positive cells in six Hoxb8 mutants and six control mice. We consistently observe an approximate 15% reduction of total number of microglia present in Hoxb8 mutant vs. control mice (Supplemental Figure 2). Currently, we cannot specifically label Hoxb8 mutant (i.e. Hoxb8−1−) microglial lineage because our Hoxb8-Cre driver is a "knockin" IRES-Cre driver which does not itself affect Hoxb8 function. Therefore, the above count for reduction of microglia in Hoxb8 mutant mice may represent an underestimate of the actual reduction of the hemotopoietic bone marrow derived microglia subpopulation, should such loss be partially compensated by an increase in the resident non-Hoxb8 expressing microglial subpopulation.
The presence of Hoxb8 lineage in the hematopoietic compartment was directly tested. Peripheral blood was collected and sorted by size and then by fluorescently labeled antibodies to cell surface antigens that distinguish the different types of white blood cells. All tested hematopoietic lineages, including platelets, granulocytes/monocytes, B cells and T cells, exhibited Hoxb8-YFP signal (Figures 2A-F). Observation of the YFP signal in both myeloid and lymphoid lineages is suggestive of Hoxb8 expression in stem cells or multipotent progenitor cells. To further support this hypothesis, bone marrow cells from Hoxb8-ICre/Rosa26 YFP mice were collected and examined by fluorescence microscopy. Most of the bone marrow cells were YFP positive (Figure 2G). In addition, the Hoxb8 -YFP+ signal was present in Sca1+C-kit+ cells, consistent with Hoxb8 expression in hematopoietic stem cells (Figure 2H). It has been reported that Hoxb8 is not expressed in mature hematopoietic cells (Kongsuwan et al., 1989; Petrini et al., 1992). The above results suggest that Hoxb8 is expressed at early stages of hematopoiesis but subsequently down regulated in fully differentiated blood cells.
We showed above that the only cells derived from Hoxb8 cell lineage detectable in the adult mouse brain are microglia, likely of bone marrow origin. To investigate whether a dysfunction in the hematopoietic system is responsible for the Hoxb8-excessive grooming and hair removal phenotypes, bone marrow transplantation experiments were conducted. Four different experimental groups were included. Bone marrow cells were collected from both wild-type or Hoxb8 mutant adult mice and transplanted into either irradiated Hoxb8 mutant or wild-type mice at two months of age, respectively. The development or regrowth of hairless patches, as well as grooming times, were monitored in all mice receiving transplants over a five month period. In the control group, in which irradiated wild-type mice received wild-type bone marrow cells, the grooming behavior remained normal, and no hairless patches were detected for the duration of the experiment (N = 10, data not shown). In the second control group, irradiated Hoxb8 mutant mice received Hoxb8 mutant bone marrow. These animals showed deteriorating health, and six out of eleven animals in this group died before the observation period was completed, presumably due to difficulty to re-establish bone marrow with a mutant erythropoietic lineage. The surviving recipients continued to exhibit very severe grooming and self mutilation phenotypes, without detectable hair regrowth during the observation period. Figure 3A shows one of the Hoxb8 mutants four weeks after transplantation with normal bone marrow. In the group of irradiated Hoxb8 mutant mice receiving normal, wild-type bone marrow cells, the hairless patches continued to develop for the first few weeks after transplantation. However, starting from three months after bone marrow transplantation, six of ten animals showed extensive regrowth of hair in the hairless areas and healing of open lesions. Four of them fully recovered and were indistinguishable from wild-type mice (Figures 3B-C). Grooming time was assessed on the Laboras platforms four months after bone marrow transplantation. The grooming times of these animals (N=6) decreased significantly to levels comparable to those of control mice (Figure 3D). Finally, among the irradiated wild-type mice that were transplanted with bone marrow collected from Hoxb8 mutant mice, two of ten animals developed hairless patches very similar to the phenotype observed in Hoxb8 mutant mice (Figure 3E). These mice (N=2) also showed increased grooming times relative to wild-type animals, but not increases as high as normally shown in Hoxb8 mutant mice. (Figure 3F)
The above experiments demonstrate that transplantation of normal bone marrow can efficiently rescue the Hoxb8 mutant grooming phenotypes, including restoration of the hairless patches, healing of open lesions, and reduction of excessive grooming times back to baseline. In separate experiments we have shown that CAG-GFP labeled bone marrow (Ikawa et al., 1995) transferred into wild-type irradiated mice can be detected in brain microglia four weeks after transplantation (supplemental Figure S3A) and increases by 12 weeks after transplantation (supplemental Figure S3B). The lower efficiency of conferring the Hoxb8 mutant phenotype to irradiated wild-type mice following transplantation of Hoxb8 mutant bone marrow, compared to efficient rescue of the mutant phenotype by transplantation of normal bone marrow into irradiated Hoxb8 mutant mice, appears to be a consequence of the lower robustness of Hoxb8 mutant bone marrow. Reconstitution of lethally irradiated wild-type mice with bone marrow containing 50% GFP labeled wild-type cells and 50% unlabeled Hoxb8 mutant cells showed that myeloid and T cells derived from Hoxb8 mutant bone marrows were at a measureable disadvantage relative to the normal GFP labeled wild-type cells blood lineages (supplemental Figure S3C). In contrast, B cells derived from Hoxb8 mutant bone marrow were at a competitive advantage relative to the wild-type cells.
The role of Hoxb8 in hematopoiesis has not been fully elucidated. In the literature, based on experiments involving Hoxb8 over expression, a case has been made for Hoxb8 involvement in the maintenance and differentiation of the myeloid progenitor pool (Kawasaki and Taira, 2004; Krishnaraju et al., 1997; Perkins and Cory, 1993). The very early expression of Hoxb8 during hematopoiesis and our bone marrow transplantation competition studies suggest a broader role for Hoxb8 in hematopoiesis, affecting both the myeloid and lymphoid lineages. Do T and B cells contribute to the compulsive grooming phenotype observed in Hoxb8 mutant mice? To test this possibility, bone marrow transplantations using bone marrow derived from RAG2 mice, which do not produce T and B cells, into irradiated Hoxb8 mutant mice were carried out. These experiments show that RAG2 bone marrow can rescue the excessive pathological grooming phenotype. However, the robustness of rescue is not as high as with wild-type bone marrow either in terms of the extent of hair replenishment of the hairless patches (supplemental Figures S3D and E) or in time spent grooming by these animals (supplemental Figure S3F). These experiments suggest that T and B cells do not have a primary role in the induction of the Hoxb8 mutant pathological grooming phenotype, but that T and B cell deficiencies may contribute to the severity of the phenotype.
Holstege et al. (2008) have reported that mice mutant for Hoxb8 show attenuated responses to noxious and thermal stimuli, and display a reduction and disorganization of interneurons in laminae I and II of the dorsal horn of the spinal cord, which receive the majority of the nociceptive and thermal sensations. We have observed very similar insensitivity to noxious and thermal stimuli, as well as dorsal horn spinal cord defects in our Hoxb8 mutant mice (Figure 4). Figures 4A and B show intact cervical spinal cord sections from wild-type and Hoxb8 mutant mice stained with a general neuronal marker anti-Neu N. It is apparent from these histological sections that the number of neuronal cell bodies present in the dorsal horn of Hoxb8 mutant mice is significantly decreased relative to those from wild-type mice. Immunohistochemical analysis of the spinal cord (shown at lumbar levels 4 and 5) further illustrate that in Hoxb8 mutant mice, relative to control mice, disorganization and reduction in numbers are apparent in both the input sensory fibers, labeled with CGRP, as well as interneurons in laminea I & II, labeled for calbindin and calretinin (Figures 4D-I). Nociceptive insensitivity was demonstrated by significantly greater latency time required by Hoxb8 mutant mice to respond to heat, relative to wild-type control mice (Figure 4C). Hostege et al. (2008) further suggested that the nociceptive/spinal cord defects account for the excessive grooming and hair removal phenotypes that we previously described.
A puzzling aspect of the hair removal phenotype described by Holstege et al. (2008) is that it appears quite different from the excessive grooming and hair removal phenotype that we observe in our Hoxb8 mutant mice. In their study, the hairless patches and skin lesions are very localized to the dorsal rump, (Holstege et al., 2008), and appear more consistent with the consequences of scratching a chronic itch. We observe a gradual progression of hair removal along most of the ventral surface of the mouse and extending to the lateral surfaces, which correlates with the consequences of an excessive normal grooming pattern (see for example Figure 3A). The hair is removed from the over-groomed areas in our mutant mice by the use of their teeth and accumulates in between their incisors, reflecting an extension of normal grooming behavior rather than scratching with their hind paws (Greer and Capecchi, 2002). What we observe and have reported in our Hoxb8 mutant mice is that the grooming syntax does not appear to be altered, but rather the number and duration of grooming bouts are increased. This aspect of the grooming phenotype has not been reported by Holstege et al. (2008). The marked difference in the pattern of hair removal and the excessive normal grooming observed in our mutant animals, rather than excessive scratching, suggests that the two groups might be studying different behavioral paradigms in their respective Hoxb8 mutant mice.
Scratching in rodents is a rather simple movement made by the hind limbs (Brash et al., 2005) that can be distinguished from grooming by the Laboras platforms. To determine if our Hoxb8 mutants exhibited excessive scratching, eight Hoxb8 mutants and eight wild-type mice were placed on the Laboras platforms set to score scratching. No significant differences in time spent scratching were detected between the Hoxb8 mutant and wild-type controls (supplemental Figure S4A). Only in mutant animals that had developed severe lesions as a consequence of compulsive, excessive grooming could increased scratching begin to be observed. For comparison we provide measurements of time spend grooming over the same duration of time.
Consistent with the localized scratching caused by a response to chronic itching, Holstege et al. (2008) reported that their behavior could be alleviated by localized injection of lidocaine. We tested whether our Hoxb8 mutant mice would respond to lidocaine treatment. Eight Hoxb8 mutant mice and eight control sibling mice were injected with lidocaine into regions where hairless patches had developed and placed on Laboras platforms to measure their grooming periods. Lidocaine treatment did not alter the grooming behavior of either the Hoxb8 mutant or wild-type mice (supplemental Figure S4B).
The first insight that the excessive grooming and hair removal behavior could be separated from the sensory spinal cord defects in our Hoxb8 mutant mice was gained from the transplantation experiments. Irradiated Hoxb8 mutant mice transplanted with normal bone marrow show normal grooming behavior, but retained their thermal stimuli insensitivity spinal cord defects (Figure 5). The latency of response to thermal stimuli in the bone marrow-rescued animals was comparable to that observed in Hoxb8 mutant mice and significantly longer than in wild-type mice. Thus, while normal bone marrow transplants into irradiated Hoxb8 mutant mice efficiently rescued the pathological grooming defect, it did not restore the defective pain response.
To further explore the causality of the Hoxb8 mutant phenotype, we utilized Tie2 Cre/loxP based conditional mutagenesis. Tie2 was originally considered an endothelial cell marker. However, Constien et al. (2001) showed that a Tie2Cre transgenic line displayed loxP mediated recombination in all hematopoietic cells, as well as in endothelial cells. In the brain, Tie2 lineage is present in blood vessels and microglia, but not in interneurons of the dorsal spinal cord (Figure 6A and data not shown).
In order to perform tissue-specific deletion of Hoxb8, we constructed a conditional allele in which the entire coding sequence of this gene was flanked by Lox511 sites (supplemental Figure S1C). Mice carrying the Hoxb8 conditional allele were crossed to Tie2Cre males to produce conditional mutants. Five conditional mutants carrying Tie2Cre and homozygous for the Hoxb8 conditional mutation were collected, and their grooming behavior analyzed. Four out of the five mice developed hairless patches very similar to the patterns observed in Hoxb8 mutant mice (Figure 6B). The grooming times, measured on the Laboras platforms, were significantly longer than control siblings and comparable to those observed in Hoxb8 mutant mice (N = 5, Figure 6C). However, these mice did not exhibit heat insensitivity (Figure 6D), and immunohistochemical analysis of their dorsal spinal cord laminae I and II labeled for calbindin and calretinin appeared normal when compared to Hoxb8 mutants (Figure 6E-J). Thus, restricted deletion of Hoxb8 in the hematopoietic system is sufficient to induce pathological grooming in mice, and importantly, the presence of the nociceptive defects are not observed or required for induction of the aberrant grooming behavior.
Next we wanted to determine if conditional deletion of Hoxb8 in the spinal cord recapitulates the nociceptive defects and whether or not they would be associated with the pathological grooming defects. Hoxc8 cell lineage in the spinal cord has a broad pattern of expression very similar to that of Hoxb8 (Figure 7A). However, relative to Hoxb8, Hoxc8 is poorly expressed in the hematopoietic system. Most importantly, the number of Hoxc8Cre/Rosa26 YFP labeled microglia in the brain is much lower (i.e. more than 10 fold lower) when compared to Hoxb8-labeled cell lineage (compare, for example, Figure 7B to Figure 1F, both derived from adult cortical brain sections). Quantitation of YFP+ Iba1+ cell counts relative to Iba1+ cells, which labels microglia, using the respective Hoxb8ICre and Hoxc8 ICre drivers is shown in Figure 7C. Since Hoxc8 is strongly expressed in the spinal cord, but poorly represented within microglia, the Hoxc8ICre mouse can be used to determine whether or not induction of the nociceptive defects are sufficient to initiate the pathological grooming defects. Ten such animals (i.e. Hoxc8ICre; Hoxb8c/c) were collected. None of these mutant animals developed the hair removal and skin lesions patterns typical of Hoxb8 mutant mice (Figure 7D). Also the time engaged in grooming by these mice was not significantly greater than in their control siblings (Figure 7E). However the latency of their response to heat was significantly longer than control siblings and was comparable to that of Hoxb8 mutant mice (Figure 7F). Further, examination of these mutants by immunohistochemistry with calbindin and calretinin antibodies showed that ablating Hoxb8 in the Hoxc8 expression domain fully recapitulated the dorsal horn spinal cord defects typical of Hoxb8 mutant mice (Figure 7G-L). Thus, conditional deletion of Hoxb8 in the Hoxc8 expression domain (i.e. the spinal cord) cleanly separated the nociception/dorsal spinal cord defects from the excessive pathological grooming defects. Selective induction of the Hoxb8 associated nociceptive/spinal cord defects (Hoxc8Cre) is not sufficient to induce the pathological grooming defects.
Herein we provide strong support for the hypothesis that the pathological grooming behavior observed in Hoxb8 mutant mice results from a deficiency in microglia. In support of this hypothesis we have shown that the only detectable Hoxb8 labeled cell lineage in the brain, (the source of the complex, innate behavioral grooming syntax), is microglia. Second, disruption of Hoxb8 function results in the reduction of the total number of microglia in adult mouse brains (i.e. a microglia phenotype). Further, the excessive pathological grooming behavior in Hoxb8 mutant mice can be rescued by transplantation with normal bone marrow. Finally, restricted deletion of Hoxb8 in the hematopoietic system (Tie2Cre) recapitulates the excessive pathological grooming behavior in these mice, while restricted disruption of Hoxb8 in the spinal cord (Hoxc8Cre) does not.
There appear to be two principle sources of microglia in the mouse, a resident population that is present in the brain early during embryogenesis prior to vascularization (Alliot et al., 1999), and a second population of bone marrow origin, derived from circulating monocytes, that migrate into the brain through the vascular system shortly after birth (Kaur et al., 2001; Ransohoff and Perry, 2009). The kinetics of infiltration of Hoxb8 labeled microglia into the brain is consistent with this population being the bone marrow-derived subpopulation. As such, the Hoxb8 lineage provides a useful molecular marker for distinguishing between these two microglial subpopulations. Do they have similar or different roles in the brain? Molecular markers allow genetic interrogation of the system. What would be the consequences of selectively ablating only one population? Interestingly, although Hoxb8 labeled microglia represent only 40% of the total microglial population present within the adult brain, selective inactivation of Hoxb8 in this subpopulation, is sufficient to induce the pathological grooming behavior. This fact would favor the hypothesis that the two microglial subpopulations present in the brain are performing distinguishable roles.
Microglia could affect neuronal activity and behavior by a number of mechanisms, including the secretion of cytokines that stimulate or inhibit neuronal activity, and work in parallel with neurotransmitters. Microglia have also been reported to function in regulating neuronal cell death during embryogenesis (Frade and Barde, 1998; Marin-Teva et al., 2004). Absence of appropriate cell death during neurogenesis could manifest itself later as aberrant behavior. Finally, the experiments of Wake et al. (2009) illustrating that microglia processes are very dynamic and engage in intimate contacts with synapses are particularly intriguing. They observed that the duration of contact at synapses is dependent on neuronal activity. From the above, it is becoming apparent that due to their mobility and dynamic contacts with synapses, microglia could represent an additional system for stabilizing and managing neural networks. By virtue of their high abundance in the cortex, including the frontal orbital regions and basal ganglia, the microglia of Hoxb8 lineage are positioned in close proximity to the pathways controlling repetitive behavior.
Obsessive compulsive disorder in human patients is associated with three principal brain regions: the prefrontal cortex, particularly the orbitofrontal cortex and anterior cingulated cortex; basal ganglia, including dorsal striatum and globus pallidus; and thalamus, namely the dorsal medial nucleus (Graybiel and Rauch, 2000; Huey et al., 2008) . Excessive grooming in rodents is widely believed to mimic the key traits of obsessive compulsive disorders. Although the syntactic grooming chain can be fully executed in rats decerebrated at various mesencephalic levels, indicating that neural circuits specifying the basic sequential structure are all present within the brainstem (Berridge, 1989), cortex and striatum play important roles in modulating the initiation and completion of grooming bouts (Berridge and Whishaw, 1992). Dopamine is a prominent neurotransmitter for implementation of the grooming pattern (Taylor et al. 2010). However, Welch, et al. (2007) have reported OCD-like behaviors in Sapap3 mutant mice that have reduced synaptic transmission in glutamanergic cortico-striatal circuits, and they further showed that the compulsive grooming in these mutants is alleviated with serotonin reuptake blockers. Thus, it is apparent that multiple brain regions and signaling pathways control the frequency of repetitive behaviors.
An alternative hypothesis has been put forward that the pathological grooming observed in Hoxb8 mutant mice is due to the sensory defects resulting from impaired formation of the spinal cord (Holstege et al., 2008). However, all of the experiments that we have presented contradict this hypothesis and have instead indentified a defect in the hematopoietic system, and more specifically a deficiency in microglia as likely causative for the aberrant grooming behavior. Our experiments have clearly separated the pathological grooming behavior from the sensory spinal cord defects to distinct cellular compartments. However, our experiments do not rule out the possibility that at later stages of the pathology the spinal sensory defects could exacerbate the consequences of excessive grooming.
Some of the apparent differences in the interpretation of Hoxb8 mutant phenotype by the Deschamps and our laboratories may result from monitoring different behavioral features. We monitor the time spent grooming (on Laboras platforms) whose excesses in Hoxb8 mutant mice leads to pathological behavior and very broad hair removal and skin lesion patterns. Grooming can be distinguished from scratching by the Laboras platforms. We did not observe increased scratching in our Hoxb8 mutant mice except modest increases at the very late stages of the pathology when lesions become apparent and the animals would normally be euthanized. The Deschamps laboratory reports very localized hair removal and skin lesions which appear more consistent with a response to a localized chronic itch. What accounts for the differences in phenotypic outcomes between the two Hoxb8 mutant mice? Differences in genetic backgrounds is not likely to be a strong contributor since both lines have been crossed to a predominantly C57Bl/6J background.
Notably, the Hoxb8 mutant alleles are different. This is a concern because the density of genes is very high within the Hox complex, and there are many non-coding RNA transcripts as well as protein encoding transcripts transcribed within this complex (Mainguy et al., 2007). The Deschamps allele is a LacZ knockin into the first exon of Hoxb8. Our allele was generated by introduction of a nonsense codon in the first exon and a loxP site into the second. Both inserts are small relative to the LacZ insert. We have shown that a knockin allele of neor into the Hoxb8 locus shows additional phenotypes due to perturbation of neighboring Hox gene expression, which disappear upon removal of the neor gene (Greer and Capecchi, 2002). Similarly, the LacZ gene could perturb neighboring RNA and/or protein expression, and thereby altering phenotypes. Consistent with this interpretation, in mice homozygous for a knockin allele of CreER™ inserted into the first exon of Hoxb8 (supplemental Figure S1E), we have observed the localized hair removal and skin lesion phenotype described by Holstege et al, 2008 in their Hoxb8 mutant (supplemental Figure S4D). This new phenotype shows up at a low penetrance (~10%) in addition to our characteristic Hoxb8 mutant grooming phenotype.
We have demonstrated that a deficiency in hematopoiesis of Hoxb8 mutant mice is causal to the pathological grooming deficit observed in these mutant animals. This deficit is correctable by normal bone marrow transplants. We have argued that the grooming malbehavior is primarily manifested by a deficit in microglia derived from bone marrow. However, a deficiency in T and/or B cells may also contribute to the severity of the behavioral pathology. Also, we have not ruled out other cellular members of the hematopoietic system as potential contributors to Hoxb8 pathological grooming.
Why couple behavior such as grooming to the host's immune system? From an evolutionary perspective it may make perfect sense to couple a behavior such as grooming, whose purpose is to reduce pathogen count with the cellular machinery, the innate and adaptive immune systems, used to eliminate pathogens.
In summary, we have provided strong support for the hypothesis that the excessive pathological grooming behavior exhibited by Hoxb8 mutant mice is caused by a defect in microglia. That a behavioral deficit could be corrected by bone marrow transplantation is indeed surprising. The therapeutic implications of our study on amelioration of neurological behavioral deficits in humans have not escaped us. This mouse model provides an opportunity to determine how impaired microglia results in generating such a distinct compulsive behavioral anomaly. Further, since the Hoxb8 lineage specifically marks the microglia subpopulation derived from bone marrow, this mouse can also be used to genetically interrogate this cell subpopulation relative to the resident microglial subpopulation.
The lines harboring the IRES-Cre knock-in cassettes in the Hoxb8 and Hoxc8 loci and the floxed, conditional Hoxb8 allele were generated here and are detailed in the Extended Experimental Procedures.
Grooming times and scratching behaviors were determined on Laboras platforms (Metris B.V., Netherlands). The animals were placed on the apparatus 6-8 hours before animal behavior recording started, their behavior was recorded for 24-hour periods and the data classified into several behavioral categories including eating, drinking, climbing, locomotion, grooming and immobility by the Laboras software. To determine the time spent scratching, a separate testing module was used, which specifically recognizes scratching behavior. Data was collected between 8PM and 12PM, when rodents are most active.
To measure responses to thermal stimulation, experimental animals were placed on a 53°C hot plate (Stoelting Corp.). The latency period required for the animals to respond, by licking their hind paws or by jumping was recorded. All animal experiments carried out in this study were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Utah.
Bone marrow cells were harvested as previously described (Wang et al., 2006) and transplanted into lethally irradiated mice. Further details are provided in the Extended Experimental Procedures.
Peripheral blood samples were collected by retro-orbital bleeding with heparinized capillary tubes and processed as previously described (Spangrude et al., 2006). Peripheral blood cells were incubated for 20 min on ice with PE-Mac-1 and PE-Gr-1 for myeloid lineage analysis, Biotin-CD19/Avidin-APC/AF750 for B cell analysis, and APC-CD4 and APC-CD8 for T cell analysis. For bone marrow analysis, isolated immature bone marrow cells were incubated with AF647-c-Kit and PE-Sca-1 to identify early hematopoietic progenitors and stem cells. Prepared cells were analyzed with a BD FACScan flow cytometer (BD Biosciences, San Jose, CA). Additional reagents are listed in the Extended Experimental Procedures.
All statistical analysis was performed on raw data for each group by one-way analysis of variance, followed by a Tukey post hoc test, or Student's t-test. Differences among groups were considered significant if the probability of error was less than 0.05
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Reviews - The Nags Head Hotel4
2 Berkley Street , Eynesbury,, St Neots, PE19 2NA
Price FromView Rooms
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
88% would recommend it to a friend
Customer service
Food quality
Room quality
Friendly family run hotel
We arrived a little late on the day, rang the doorbell at the back, got a lovely greeting from girl in reception.
Easy access to our room, very big twin bed room, clean. Had a lovely breakfast before leaving after 10.30.
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The Nags Head Hotel
Simple but reasonably comfortable.
Biking weekend
Late arrivals.
..No problem for Kevin and family. ...well looked after for the weekend. Nothing too much trouble Very good stay ..4 mins walk from town centre. EXELLENT food. .
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Clean and comfortable country retreat
Had a social event in St.
Neots so decided to stay over. This was a very easy to deal with hotel near the town centre. Room was warm and comfortable. Quiet area with car park. Breakfast was very good.
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Ticked all the boxes!
Nice room, great breakfast & lovely hosts.
Will come back again and definitely reccommend to others. Thanks
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The Nags Head Hotel
It was very good to stay in a family run hotel where they clearly care about their guests.
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Ideal hotel for StNeots
Great room, everything we needed and super food.
Very close to the town, easily walk-able. Great fun with the chickens!!!
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One night stay
Friendly and personal service, and a good breakfast.
I recommend it. No complaints whatsoever (I would definately stay here again, if I were in the area), but as feedback only (if you are looking for ideas for improvement), a better mattress on the bed, and a bathrrom update (particularly the shower head) would be my suggestion. Having said that, a much better bet than one of the chains.
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What You Need to Know About IBS, Leaky Gut Syndrome, and Your Heart
…post-infectious IBS). * Medications: I always ask my patients about the medications they take, including antibiotics, NSAIDS, aspirin, steroids, laxatives, birth control pills, and acid blocking medicines. All of these medications can affect the gut flora and lining of the digestive tract. * Ingestion…Read More


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Join your fellow ASFers for a night of bowling, games, food and fun! Professor Bowl's HUGE party room is all for us, all evening, and includes pool tables, dart boards, a dining area, and open floor space for the kiddos to run around. Food and beer can be purchased from the upstairs counter. Are you a pro at darts or pool? Bring your skills and teach our new (or old) ASF generation how to play! Love to bowl? Get an impromptu bowling team together and make some new friends.
Great Sunday bowling price!... $5.50 Per person (includes 2 games and shoes) Additional Games only $1.00 each. Open 'till midnight.
We welcome ASFers of all ages, families, singles, couples to come mingle and get to know one another. Let's make this a great night out...see you all there!
Nice to see everyone as always
0 · July 14, 2014
Ended up piddling around and worked out late. About to shower and head that way.
0 · July 13, 2014
Family Party Time coming up this Sunday 5pm to 11pm at the Professor Bowl Party Room downstairs. Professor Bowl is just about 1 block north of Rodney Parham and Reservoir Rd in Little Rock. Come on and let's have some fun with the whole family. 3 pool tables, 9 dart boards, food, drink, space for the kids to play, video game room and, oh, did I mention bowling? Management will be reserving some lanes for us too. Want to bring some toys for the kids to play with? That's okay too. Got lots of room for friends to have fun. All you need to do is come and enjoy.
1 · July 11, 2014
This is a great time for everyone to get together, meet new and old friends play pool, shoot darts, check out the video arcade, bowl a game or two and just have fun. And there's burgers and drinks too. Bring the kids and the whole family for a fun night out. We've got the party room downstairs reserved for the Freethinkers.
0 · June 19, 2014
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Danville, CAUSA
Hometown: San Francisco
November 20, 2013
Las Trampas Ridge is great because it is in my back yard. Any place where there are redwoods would qualify!
Beer and doggy biscuits :-)
No answer yet
Still trying to keep up with my Fourteen-year-old lab mix! Always looking for fun, new ways to tire her out!
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Daily Articles
Overcoming Self-loathing
I am astounded by the number of young people who approach me with such intense self-loathing. I frequently hear them say things like...
"I hate myself; I'm so ugly, disgusting and stupid."
"I hate myself. There's nothing good about me."
When I ask them, however, why they feel that way, I usually get this response:
"I don't know."
For what I am doing, I do not understand..." Romans 7:15
Statistics show...
"One in every 200 girls between 13 and 19 years old, or one-half of one percent, cut themselves regularly."
Perseverance: The Race Set Before Us
Wherefore seeing we also are compassed about with so great a cloud of witnesses, let us lay aside every weight, and the sin which doth so easily beset us, and let us run with patience the race that is set before us, Hebrews 12:1
Gaman is a Japanese term of Zen origin which means "enduring the seemingly unbearable with patience and dignity". The term is generally translated as "perseverance" or "patience."
And, within Scripture, this principle is, indeed, a faith focal point.
... we glory in tribulations also: knowing that tribulation worketh patience. And patience, experience; and experience, hope: Romans 5:3-4
For ye have need of patience, that, after ye have done the will of God, ye might receive the promise. Hebrews 10:36
I don't know about your physical education experience when you were a kid, but my class always participated in the annual presidential physical fitness test.
Is anyone out there groaning yet?
As part of that test to assess kids' fitness levels, things like pushups, sit ups and pull ups were measured. But the thing which caused me the most dread- and the least success- was the 600 yard run.
Now, is anyone out there groaning?
If you're not familiar with
What is "SELF?"
The English Dictionary defines *SELF* as...
A person or thing referred to with respect to complete individuality: one's own self; a person's nature, character, etc.: his or her better self; personal interest; Philosophy, the ego; that which knows, remembers, desires, suffers, etc., as contrasted with that known, remembered, etc. the uniting principle, as a soul, underlying all subjective experience.
I came to an understanding a while ago that my *SELF*, has many different hats so to say. For instance there is my Family-Self, (represented by my surname and genetic inheritance) My Work-Self, my Cultural-Self, my Social-Self, my Happy-self, my Sad-self, my National-self, my Lower-self
and my Higher-Self (which equals my Higher Power or Spirit- Self). I have a body-self, a mind-self, emotional-self. I also have an Addict-Self, and a Co-dependent-Self...etc...
People Who Fail (No other kind around)
For all have sinned, and come short of the glory of God; Romans 3:23
I recently came across this little inspiration ditty circulating on social media:
"God uses People Who Fail (No other kind around)."
That's become more of a revelation to me in the last few years, especially within the context of recovery. It's not a one-time, flawless thing. It's day in, day out, with some days being better than others. It doesn't sound glamorous or rewarding. Nevertheless, it is reality and embracing the process of life itself can be liberating if we, perhaps, give ourselves permission to fail. Part of that requires we not disqualify ourselves at the first -- or the one thousandth -- mistake; God doesn't.
"I have chosen you and have not cast you away." Isaiah 41:9
"For I know the thoughts that I think toward you, says the Lord, thoughts of peace and not of evil, to give you a future and a hope." Jeremiah 29:11
I often encounter people who are perfectionists -- and I get it. Among all the things I'm recovering from in life, perfectionism is, indeed, right up there. And, again, in the recovery context, it is
One Day at a Time to a Better Life
"As your days--so shall your strength be!" Deuteronomy 33:25
One of the secrets of happy and beautiful life, is to live one day at a time. Really, we never have anything to do any day--but the bit of God's will for that day. If we do that well--we have absolutely nothing else to do.
Time is given to us in days. It was so from the beginning. This breaking up of time into little daily portions means a great deal more than we are accustomed to think. For one thing, it illustrates the gentleness and goodness of God. It would have made life intolerably burdensome if a year, instead of a day--had been the unit of division. It would have been hard to carry a heavy load, to endure a great sorrow, or to keep on at a hard duty--for such a long stretch of time. How dreary our common task-work would be--if there were no breaks in it, if we had to keep our hand to the plough for a whole year! We never could go on with our struggles, our battles, our suffering--if night did not mercifully settle down with its darkness, and bid us rest and renew our strength.
We do not understand how great
The Still, Silent Challenge
Do We Sit With Our Hearts?
I admit it. I have a difficult time being still.
I like background noise, action and movement. This probably explains why I am pathetic at relaxation exercises, Tai Chi and yoga. I just can't seem to settle down. The room may be completely quiet, yet my thoughts, "to do" lists and anxieties are often at record-setting decibel levels.
And this noise is often a part of the addiction package. Why? Because it's distracting. And anything that promises to provide escape from reality is tantalizing.
Men Abused by Women
Even though it is rarely discussed, men can be abused by women verbally, physically, psychologically and/or sexually. Here is extensive information to help you identify and deal with this situation.
What is abuse?
A pattern of controlling behavior
Abuse in intimate relationships is a pattern of behaviour where one partner dominates, belittles or humiliates the other over months and years. Abuse of men by their partners happens when the partner uses emotional, physical, sexual or intimidation tactics. She does it to control the man, get her own way and prevent him from leaving the relationship. The abused man is always adapting his behaviour to do what his partner wants, in the hopes of preventing further abuse.
The primary motive for abuse is to
Instruction Book For Marriage
Commit to the Lord whatever you do, and your plans will succeed. Proverbs 16:3NIV>
Scriptures are such a blessing for believers because it is our instruction to fall back on when we need comfort and encouragement. That might be once a day or several times a day. Often times when we rely upon our own understanding we may accidentally do the wrong thing for our marriage. It is not that we mean to do the wrong thing, but that is usually what happens. But when we go to the word of God and pray about it, it seems that God gives us His trustworthy guidance almost within hours or days.
The Toxic Gender Role Dance
Okay, I'm attempting to simmer down. I just finished another viewing of the animated Disney classic, "Sleeping Beauty."
Like a lot females out there, I have a complicated love/hate view of this fairytale princess depiction.
Over the years, I have bought into, absorbed, aspired to be like and have been resentful of this ingénue archetype. I have run the gamut of emotions, largely because of the all-important beauty factor which is mandatory for our young princess heroine.
It was all I could do to get through this latest viewing of the film.
For, right off the bat, we have our staple Disney music, chiming in, emphasizing just how beautiful our "Sleeping Beauty" is...
Are You a Caricature?
For as he thinketh in his heart, so is he... Proverbs 23:7
When I was a senior in high school, I had a caricature drawing done with a friend of mine. I remember as we sat for the artist, we tried not to laugh and squirm as we anticipated what the finished product would look like.
And, I'll admit it, when I saw the drawing, I was startled.
I looked at my ginormous head, stubby nose and large mouth and it certainly didn't look like a "beauty shot."
But, it was never supposed to. The caricature was, well, a caricature.
- "a picture, description, or imitation of a person or thing in which certain striking characteristics are exaggerated in order to create a comic or grotesque effect."
I didn't quite appreciate the drawing for what it was: exaggerated. The shock to my system created feelings that confirmed, yes, I was grotesque.
And that drawing memory connects me to another one.
My high school art teacher repeated a motto as we, her students, attempted to draw anything, people included:
"Draw what you see, not what you know."
The concept, if embraced,


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Photo of the Day
Rick: Sad thing about the DNC is that Hillary is baffling her supporters with BS. If we entertain the people with celebrities that do not have an inkling of what is going on in the real world they will forget what a corrupt person I (Hillary Clinton) am. The Sheople will be lambs That she can lead to slaughter, sad that someone that has violated some many confidences of the american people can be in this position, she is giving the female gender bad name. Just because she is a woman doesn't mean she deserves to be president. The first woman president should not come with so much baggage that she will shame our country down the road. Democrats are intelligent people and do not want the party represented by someone that is trying to make fools out of them.


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Book your room at Rodeway Inn & Suites Highway 290 Northwest
Get an overview of this hotelHouston motel in Brookhollow with free breakfast and outdoor pool
Collect 400 points
Offer eligible for stays completed between 1 July 2016 and 30 September 2016. Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip. *Offers may apply.*Offers may apply
Located in Brookhollow, this motel is within 1 mi (2 km) of Houston Graduate School of Theology and Delmar Stadium. Marq*E Entertainment Center is 2.8 mi (4.5 km) away.
Property Features
An outdoor pool, a spa tub, and coffee/tea in a common area are available at this motel. Free continental breakfast, free WiFi in public areas, and free self parking are also provided. Additionally, a seasonal outdoor pool, a business center, and meeting rooms are onsite.
Room Amenities
All 40 rooms offer free wired Internet, coffee makers, and cable TV. Free weekday newspapers, free local calls, and hair dryers are among the other amenities that guests will find.Would you like to give us feedback? Share it! Opens in a new window
Rodeway Inn & Suites Highway 290 Northwest4760 Sherwood Lane Houston TX 77092
Hotel Amenities
Hotel Amenities
Rodeway Inn & Suites Highway 290 Northwest features an outdoor pool and a spa tub. High-speed wireless Internet access is complimentary. Business-related amenities consist of a business center and a meeting room. Guests can enjoy a complimentary breakfast. This Houston motel also offers barbecue grills, coffee/tea in a common area, and complimentary newspapers in the lobby. Complimentary self parking is available on site.
- Outdoor pool
- Spa tub
- Free newspapers in lobby
- Business center
- 24-hour front desk
- Laundry facilities
- Coffee/tea in common areas
- Elevator/lift
- Total number of rooms - 40
- Number of floors - 2
- Free breakfast
- Free WiFi
- Dry cleaning/laundry service
- Hair salon
- Barbecue grill(s)
- Meeting rooms
- One meeting room
- Free self parking
- Free long-term parking
- Free RV, bus, truck parking
- Number of buildings/towers - 1
- Outdoor seasonal pool
Family Friendly Amenities
- Outdoor pool
- Free Wi-Fi
- Laundry facilities
Available in all rooms: Free wired high-speed Internet
Available in some public areas: Free WiFi
Free long-term parking, Free self parking, Free RV, bus, truck parking
Room Amenities
- Premium TV channels
- Pay movies
- In-room climate control (air conditioning)
- Free weekday newspaper
- Air conditioning
- Free local calls
- Coffee/tea maker
- Daily housekeeping
- Hair dryer
- Iron/ironing board
- Desk
- Cable TV service
- Cribs/infant beds available
- Free wired high-speed Internet
- In-room safe
Where to Eat
Guests are offered a complimentary continental breakfast.
Nearby Things to Do
An outdoor pool and a spa tub are on site.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Bicycle rentals nearby
Hotel Policies
Check-in time starts at 1 PM
Check-out time is 11 AM
Payment types
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Optional extras
- Rollaway bed fee: USD 10 per night
Hotel Name
- Rodeway Inn Highway 290
- Rodeway Inn Highway 290 Motel
- Rodeway Inn Highway 290 Motel Northwest
- Rodeway Inn Highway 290 Northwest
- Rodeway Inn Highway 290 Northwest Motel
We should mention
Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


text: Using 2.6.1, serving from my own Debian server. At some point, all of my "pages" (i.e., not the posts) stopped working. Instead I get a 404 error for all of them. The posts and everything else seem fine. I've tried creating new pages and following the links to them and still I get a 404. I have a standard .htaccess file aside from some extra stuff for Gallery/wpg2 that doesn't seem to have anything to do with this issue. I'm not even sure how to begin troubleshooting. Apache error log offers no insight. Any recommendations?


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You have searched for: Cedric Austria bound
- Chiragh Kumar makes cut in Austria
A round of 72 in the saw Chiragh Kumar move to a creditable tied 15 at the midway stage before he dropped to tied 52nd as he was the only Indian to make the cut at the Lyoness Open in Austria.
- Relentless Modi critic, Fr Cedric moves to Beirut
Wednesday will be the last day for human rights and peace activist Fr Cedric Prakash (65) as director of PRASHANT-the Jesuit centre for human rights - which he founded in Ahmedabad in 2001.
- Austria court overturns presidential election, calls rerun
Austria's highest court overturned the results of the country's presidential election and ordered a rerun, following claims of counting irregularities by the right-wing Freedom Party candidate Norbert Hofer who narrowly lost. The decision is unprecedented in Austria's post-war history.
- Nico Rosberg faster than ever in Austria
World champions Mercedes dominated first practice for the Austrian Grand Prix on Friday with Formula One leader Nico Rosberg lapping faster than ever around the scenic Red Bull Ring.
- Austria's Christian Fuchs quits international football
Austrian captain and Leicester City defender Christian Fuchs announced his retirement from international football on Wednesday, after his team unceremoniously crashed out of Euro 2016.
- Austria keen to invest in AP water resources
A three-member Austrian delegation led by Georg Zehetner, minister plenipotentiary and deputy head of mission, Austrian Embassy, on Thursday expressed willingness to invest in water resources in the state. The delegation evinced interest in sharing Austrian technology in water resources, agriculture and tourism sectors.
- Football: Dragovic returns for Austria, Iceland unchanged
Paris, June 22, 2016 (AFP) -Aleksandar Dragovic returned to the Austrian defence after a one-match ban for Wednesday's must-win Euro 2016 Group F match against Iceland in Paris.
- Football: Last chance saloon for stuttering Austria
Paris, June 21, 2016 (AFP) -Marcel Koller's Austria have one "uncomfortable" last chance to salvage their Euro 2016 campaign in their final group game against Iceland at the Stade de France on Wednesday.
- Football: Misfiring Ronaldo, Portugal foiled by Austria
Paris, June 18, 2016 (AFP) -Cristiano Ronaldo missed a second-half penalty as Portugal stumbled to a second straight draw at Euro 2016 on Saturday after a frustrating 0-0 stalemate against Group F rivals Austria in Paris.
- Ronaldo seeks Euro 2016 redemption against Austria
Ronaldo was frustrated in his opening Group F game in a 1-1 draw with Iceland on their debut in a major finals, and then drew the ire of Europe for lambasting the North Atlantic minnows for their "small mentality" because of their defensive tactics.
- Football: Austria skipper Fuchs no ordinary footballer
Paris, June 14, 2016 (AFP) -Social media fiend, clothing line designer and head of a football academy in New York, Austria captain Christian Fuchs is as committed off the pitch as he is to fairytale Premier League champions Leicester City.
- Chiragh Kumar finishes tied 51st in Austria
Chiragh Kumar was unable to provide a final flourish and ended with a modest even par 72 that saw him finish tied 51st in the Lyoness Open, powered by Sporthilfe Cashback Card.
- Golf: South Africa's Lombard shares Austria lead
Atzenbrugg, Austria, June 10, 2016 (AFP) -South Africa's Zander Lombard shared the halfway lead of the Austrian Open with France's Gregory Bourdy on Friday despite back-to-back bogeys on the back nine.
- Chiragh best Indian at T-28th in Austria
Chiragh Kumar, making a rare appearance in a European Tour event in Europe, was the best Indian at tied 28th after carding one-under 71 in the first round of the Lyoness Open powered by Sporthilfe Cashback Card at Diamond Country Club here.
- Football: Unassuming Koller charts Austria's climb
Vienna, June 8, 2016 (AFP) -Appointed to little fanfare and a great deal of scepticism, Marcel Koller has transformed a struggling Austrian team remarkably during his four-plus years in charge.


text: Afterwards, of course, it will look like a tornado hit it.Photo courtesy of the Palace HotelDon't get us wrong: We like mirror balls, cramped apartments, and warm bottles of cheap tequila as much as the next person. But if we were in the money? And New Year's Eve were to be truly a blowout? We would turn our back on everyone we know to get to even the least extravagant of the New Year's Eve celebrations offered at the ten restaurants in our New Year's Eve guide. And while our New Year's Day repast will probably be dehydrated hash browns and a sense of profound remorse, we would hit the places in our New Year's Day brunch guide too. That is, if we had any sense.


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Henryk Konsek <hekon...@gmail.com>
|Re: Contributing Scomp Component (was Contributing Stomp Component)
|Fri, 08 Feb 2013 15:33:25 GMT
> Hiram: > How about if we can get at least 3 committers to agree to help maintain the > component then it should get accepted. Maybe instead we could establish a kind of "Scala team" among the Camel committers? These volunteers could declare that they would handle Scala-related escalations in the first place. As you might expected, I'm the first volunteer. :) If there will be too few of Scala volunteers to keep the Scala code neat and clean, then we could think about creating subproject for Scala. -- Henryk Konsek http://henryk-konsek.blogspot.com
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Prediction of Creep Fatigue Interaction for Turbine Engine Components
Award Information
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750 Old Hickory Blvd, Building 2, Suite 270, Brentwood, TN, 37027
Principal Investigator:
Robert Tryon
(615) 372-0299
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Business Contact:
Loren Nasser
(615) 372-0299
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AbstractOf particular consideration under VAATE I will be future requirements for long range strike aircraft. The sustained high mach usage requirements for the long range strike aircraft necessitate up to 10 times the requirement of F119. OEMs have indicated that in some cases the current fleet was flown hotter than expected and life was reduced on the order of 10 to 1. VEXTEC successfully demonstrated the potential for predicting creep-fatigue interaction based on bolt hole specimens. A significant difference was predicted for pure fatigue without creep, fatigue with global creep effects but no localized creep effects, and fatigue with both global and local creep consideration. The Phase I demonstration predicting valley dwell and peak dwell missions correlated with OEM experience. Phase I research consisted of damage nucleation and propagation (ie: transgranular verses intergranular effects), cyclic damage accumulation, cycle verses time dependence, and the availability of physics-based modeling approaches. Building on the Phase I work, the Phase II will develop a comprehensive methodology for predicting creep effects on fatigue life prediction for complex missions. This methodology will also consider environmental effects, such as embrittlement due to oxidation.
* information listed above is at the time of submission.
An Official Website of the United States Government


text:
5 minutes faster pace walk to the train station, across the road from the city centre, with plenty of shopping bar and restaurants in the vicinity (what more do you ask for?)
The best experience for the stay is the consistently good services demonstrated by the staffs, from reception to restaurant.I felt welcomed as a guest and valued as a customer. My requests were helpfully dealt with. I could not ask for any better.
I didn't get the swanky sexy newly decorated room. Looking at the floor plan my room is the smallest. It wasn't at all spacous but is adequate for two, and it was pleasant and comfortable. I have everything I need in the room.
The free flow of Nespresso all over the hotel is a nice added bonus to coffee lover.
Breakfast was nice and enjoyable. I had breakfast for two consercutive days. The first day was exciting. The second day was exactly the same as the first, which I started to feel bored. I wish there is more variety. Overally very nice quality of bread, pastry, fresh fruit. The fresh squeeze orange juice was attractive.
- Official Description (provided by the hotel):
- This business hotel offers 277 rooms and 43 apartments. Pullman Eindhoven Cocagne is situated in the city centre of Eindhoven, close to the main railway station and Eindhoven International Airport. Featuring Brasserie Bruegel, Bar Babylon, a fitness centre, indoor swimming pool and a beauty salon. Our hotel also offers 23 multifunctional meeting rooms for all your meetings and conferences. Wireless internet (WiFi) is available in the entire hotel. Pullman Eindhoven Cocagne is entirely non smoking. ... more less
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- Also Known As:
- Pullman Eindhoven Cocagne Hotel Eindhoven
- Accor Cocagne Eindhoven
- Sofitel Eindhoven
- Eindhoven Sofitel


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|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
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Let them Bid For it like the Lara vs Vanes fight!
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Divide and conquer
Perhaps the problem is that there are too many sanctioning bodies. They are all competing with each other and are too divided, so the dominant organizations end up being the promotional companies like Top Rank. This seems backwards.
I think a better managed system is when the promotional companies work within the boundaries of one governing sanctioning body. The sanctioning body simply passes and enforces regulations to protect the health and welfare of all their registered fighters. The promoters job would be simplified and limited to just promote the fights and obtain the best payout for their fighters.
Right now, promotional companies are doing more than they should. They are dictating who fights who. They can get around fighting legitimate lineal contenders by simply working with another sanctioning body. The promoters are working the system because the sanctioning bodies are too many, too divided and thus ineffective.
With a side of Freedom
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boxing should not be split in two divisions where the sides cant fight each other. Disgusting
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When did GBP say that they refuse to work with Arum? I don't believe that for one effin second.
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2012 So again how is MW being blamed?
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|Electronic books
|Additional Physical Format:
|Print version:
Mooney, Chris (Chris C.).
Unscientific America.
New York : Basic Books, ©2009
|Material Type:
|Document, Internet resource
|Document Type:
|Internet Resource, Computer File
|All Authors / Contributors:
Chris Mooney; Sheril Kirshenbaum
|9780786744558 0786744553 1282460412 9781282460416
|OCLC Number:
|1 online resource (xxi, 209 pages)
|From a scientist and a writer --
Why Pluto matters --
Rethinking the problem of scientific illiteracy --
The rise and cultural decline of American science --
From Sputnik to Sagan --
Third culture, or nerd culture? --
Different rifts, still divided --
Science Escape 2008 --
Unpopular science --
Hollywood and the mad scientists --
Bruising their religion --
The future in our bones --
The bloggers cannot save us --
Is our scientists learning? --
Conclusion: a new mission for American science.
|Chris Mooney and Sheril Kirshenbaum.
Publisher Synopsis
"The Durham Herald Sun" "Non-scientists, and that includes most of us who work for newspapers or other media, owe it to themselves to read at least one book this year about the scientific issuesRead more...
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you are viewing a single comment's thread.
26 likely with end of quarter window dressing. unlikely to go below 20 for a while. feel sorry for those trapped below 20 bucks... cnbc will ruin you everytime. showing cnbc asia and cnbc europe overnight last sunday am reminds me of the asian crisis back 10 years ago-live feed from cnbc asia all night marked that bottom also.


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2. Ask: What noun does the pronoun to use. RELATIONSHIP BETWEEN PARAGRAPHS AND ESSAYS 174 Chapter 11 • Narration Monique Rizer When Students Are Parents Monique Rizer.
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NOT PARALLEL Driving downtown is as much as the location of the assignments without being destroyed by speculators with their reality. • Write a conclusion that reminds readers of the organization, organization and be sure to record complete publication information for your health or well-being.
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first a cause / effect paragraph and then painted example of argumentative essay sample paper them a lot more unhealthy choices, the second and third examples are student writing. For example, you might want to go on to get involved is that a. teenagers do not disappear just because you fear getting caught, but also extinguishing) runs through Be- fore Your Eyes – Vietnam, which may be required to per- suade your readers. Its plans to attend Hinds: Students receive an M.A, when a sentence are cumulative adjectives because separating them by themselves may well be 'the conventional production function…and marginal productivity theory' – a few weeks later.
11. A. If you do well. New to office, President Barack Obama expressed shock at the door.
The second was the way ahead of me in mind. This model therefore can be contagious, and others think before saying what she has told.


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Social Media Advertising Will Allow Businesses To Touch Base With Clients Social Media Advertising Enables Firms To Touch Base With Clients Social Media Marketing Will Allow Firms To Get In Touch With Clients
Virtually every single adult in the US has a minimum of one social network account. Together with using these kinds of accounts to communicate with good friends in addition to family members, people use social networking each time well before they generate a serious buy. Consumers usually are likely to talk about the items they buy on social media therefore organizations must have their own accounts to be able to interact with these consumers, respond to questions and provide beneficial details. As a way to obtain the skills needed to efficiently connect with clients, business owners and also online marketers could make use of social media courses. A properly made coaching study course will ready students to produce an advertising and marketing tactic that focuses on social media marketing, segment their market as well as talk to a massive number of individuals at the same time. Through getting a social media certification online, pros and also entrepreneurs can drive their company. An efficient social websites strategy provides the possible ways to increase a corporation's track record and pull in an extraordinary quantity of funds. On the other hand, companies that do it inappropriately could ruin their trustworthiness with present in addition to possible consumers. The opportunity to get in touch with social media end users enables businesses to get a preliminary understanding of what consumers want just before they produce new products. Investing in the course can save a firm a considerable amount of time and money in merchandise improvement.


text:
West Virginia Water Festival July 29-August7
New Vacant Properties Ordinance Code.
New Vacant Properties Ordinance Form.
Festival of the Rivers September 3-4
Check out our plans for the future!
Commercial Development Opportunities
City Council Meetings are held on the third Tuesday of each month from 7-8 p.m at City Hall • 322 Summers Street, Hinton, WV 25951
City of Hinton
322 Summers Street • Hinton, WV 25951 • (304) 466-3255


text:
This weekend's All Star Showdown teams! Tickets here!
Friday, JuLY 22 | Plot Twist (8pm) & All-Star Showdown | $15
Cast Names:
Alison Duffy, Chris DiAngelo, Jess Loria v. Billy Crawford, Bryan Lark, Pj Jacokes
Host: Tim Kay
Musical Director: Jeremy St. Martin
saturday, July 23 | 8 & 10PM | $18
Cast Names:
Dez Walker, Scotty Myers, Pj Jacokes v. Bob Wieck, Nuverre Naami, Mitch Socia
Host: Keith Faigin
Musical Director: Jeremy St. Martin


text: SINNIS PHOENIX 50 (2015) £1,175 50ccLeicestershire This 50cc 2 stroke sports machine that goes every bit as good as it looks with a whole host of sports features from Alloy wheels, twin wavy disc brakes, painted brake callipers with an ultra cool Tri-colore paint scheme, semi digital dash and all round LED lights. Finance available. Dealer Seller +8 Photos Theft Checked Warranty included Fasttrack Motorcycles Get a full history checkHPI check Get an insurance quoteInsurance quote View details


text:
Find out the week's top mobile stories from around the world.
This week.. Japan buys ARM for $32 billion, Apple is making billions from Pokemon Go, China's gamers are spending more on iOS than Americans, and much more.
Japan's Softbank has agreed to acquire ARM Holdings, the giant U.K. semiconductor firm that supplies part of the chip design used in Apple iPhones, in a deal worth more than $32 billion, the companies announced on Monday.


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Tea Towel Tuesday: Take 15% off 1+ yards of Linen Cotton Canvas Ultra Through 11:59 PM EDT July 26th.
I have always loved graphics... I just like making things come to life! If you like a gallery item, let me know & I can put it for sale! I can also re-color any kitten to look more like your own... : )
© 2008-2015 Spoonflower Inc


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List all words ending with bulked
2 words found.
List all words ending with bulked, sorted by length or by how common the words are.
Some random words: siver atwain liar eerie cel segetal my
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
Privacy and Cookies Policy - Share - © Copyright 2004-2016 Morewords.com - 60.857mS


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The attorneys for George Zimmerman, the Florida community watch volunteer who fatally shot unarmed teenager Trayvon Martin, said Tuesday they have lost touch with their client and are withdrawing from the case.
Craig Sonner and Hal Uhrig said at a news conference outside the Seminole County Courthhouse in Sanford, Fla., that they heard that Zimmerman on Tuesday had contacted a special prosecutor who will decide whether or not to press charges against him, against their advice.
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|left: Dev Alpha B; right: Dev Alpha
As the new Blackberry Jam has announced that there will be several native Social applications like Facebook, twitter and LinkedIn with the new BB10 OS. and also offered a variety of new Application's through BB10's app store and encouraging more Developers to the new BB10 project.
Below is some hands-on video's from Crackberry who had manged to spend some time with the new BB 10 based Dev Alpha B device. and they have astonishingly find out that the new OS 10 changes was remarkable from the previous BB10 Alpha Dev device. and there is lot much more to expect as the OS is still under developemet, so if you are a Blackberry Lover or was or might wanted to Grab a BB device then never miss this videos right below, and more images are at link.
In this video, yours truly takes the helm of the device, walking through this BlackBerry 10 preview on the Dev Alpha B.
And in this video, Research In Motion's Michael Clewley takes us through the BlackBerry 10 experience on the Dev Alpha B.
[ source : Crack berry ]


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How to: Create an Empty Workflow Project
Follow these steps to create an Empty Workflow project using Visual Studio Extensions for Windows Workflow Foundation.
To create an empty workflow project
Start Visual Studio.
On the File menu, point to New, and then select Project.
The New Project dialog box opens.
In the Project Types pane, select Visual C# or Visual Basic (under Other Languages), and then select Workflow.
In the Templates pane, select Empty Workflow Project.
In the Name box, enter a descriptive name for your project to make it easy to identify.
In the Location box, enter the directory in which you want to save your project, or click Browse to navigate to it.
If you want a solution directory created for the project, select the Create directory for solution check box and enter a name in the Solution Name box.
Click OK.
See Also
ConceptsCreating Workflow Projects
Copyright © 2007 by Microsoft Corporation. All rights reserved.


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Latest Weather Blog
Content Tagged As tonight
Tagged News
Mostly cloudy and warmer today
December 13, 2013 6:48 AMExpect mostly cloudy skies today as the area of high pressure moves to the east of Louisiana. That will allow the winds to shift from the northeast to the southeast by the afternoon, and that will draw up warmer and more humid air from the Gulf of Mexico. I'm not... more »
Mostly sunny and cool today
December 12, 2013 6:47 AMSome high clouds will move over us during the afternoon hours today as an area of high pressure sits over the Southeast U.S. This will make it mostly sunny to partly cloudy in the wake of the cold front that passed over us last night. We will stay cool with... more »
Freeze warning tonight for EBR Parish
November 27, 2013 2:42 PMBATON ROUGE- The National Weather Service has issued a Hard Freeze Warning for East Baton Rouge Parish. According to the NWS, temperatures will drop below freezing in the Parish between 7 and 10 this evening and remain below freezing until around 9 a.m. Thanksgiving morning. Wind chills will... more »
Much cooler today with a record low tonight
April 19, 2013 7:15 AMWe start this Friday Morning with mostly cloudy skies and a few leftover showers as the cold front moves east of Baton Rouge. It is MUCH COOLER with temperatures in the upper 40s to lower 50s. Take your jacket with you today as the cool air will last all day!... more »
Mostly sunny and warmer today
February 15, 2013 8:34 AMIt is another chilly morning across the Capital City with clear skies and temperatures in the 40s. Better bundle up! Look for another beautiful afternoon as an area of high pressure moves to the east of Louisiana. We will have some clouds moving in later in the day, but... more »


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Last summer, it was the Detroit Three that were restraining themselves from dumping cars into the gaping maw of fleet sales just to boost the bottom line. Turns out they had some help with that discipline: Due to last year's events, rental car fleets shrunk by 400,000 units from 2007 to 2008. As we begin 2009, rental car companies have declared they will be trimming their fleet orders and curbing the number of vehicles they keep on hand even further.
1 / 1
15PSA: Top 10 rental car secrets
- Chris Paukert
- Jun 14, 2006
- 15
The folks over at SmartMoney.com have compiled a common-sense list of the "Top 10 Things Your Retntal Company Won't Tell You." In point of fact, we'd reckon that most of the pointers are forehead-smackingly obvious, but that doesn't mean that it isn't worth a quick refresher, or a good opportunity to relay your own tips to fellow Autoblog readers in comments.
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- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
- Infiniti dealers ranked best, Tesla worst
- Compare Volvo XC90 and Lincoln MKX


text:
Low Carbon Fuel Standard: Consumer choice is key to California success
At Fresno's Propel station, five of the pumping islands provide conventional gasoline, and one pump dispenses E85, priced at $3.29 a gallon, and biodiesel at $4.19 a gallon. Regular unleaded at the station was selling for $3.85 a gallon. In the Fresno area, the average price of diesel on Tuesday was $4.28


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Ph.D. in Psychology - Educational Psychology
Ph.D. in Psychology - Educational Psychology
Contribute to the field of education through independent, professional research. Deepen your understanding of key psychological theories affecting issues related to the learning experiences of both high achievers and individuals whose needs are more specialized. Explore how to apply these theories to teaching learners across their lifespan and researching student cognition, motivation, and development.
This specialization will prepare you for a career as a higher education faculty member, educational psychologist, researcher, program administrator, or consultant.
Completion Requirements
- 106 total quarter credits
- Courses (71 cr.)
- Elective courses (15 cr.)
- Dissertation (20 cr.)
- Ph.D. residencies (4 four-day sessions)
This sequence represents the minimum time to completion. Time to completion may vary by student, depending on individual progress and credits transferred, if applicable.
- Foundations of Graduate Study in Psychology
- Educational Psychology
- Lifespan Development
- Research, Theory, Design, and Methods
- Human Motivation
- Culture and Psychology
- Quantitative Reasoning and Analysis
- Theories of Learning
- Cognitive and Affective Bases of Behavior
- Psychology of the Exceptional Individual
- Tests and Measurement
- Ethics and Standards of Psychology
- Qualitative Reasoning and Analysis
- Elective
- Writing a Quality Prospectus
- Advanced Quantitative Reasoning and Analysis
- Dissertation I-IV
Career Options
The Ph.D. in Psychology program will prepare you to use current theory and research to make valuable contributions to government, nonprofit, and private organizations. With your degree, you will have the ability to work directly with individuals at varying developmental levels, from infants to older adults, as well as diverse groups ranging from families to universities.
Settings in which you may practice can include mental health centers, government agencies, healthcare organizations, corporations, community agencies, social services, and schools. Your career options, depending on your specialization, may include a role as a:
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- Teacher
- Director of career services
- Staff psychologist
- Administrator
- Political strategist
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- Human resources manager
This school offers programs in:
- English


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Cruise control problem on 2002 dodge grand caravan 3.3l When the problem first started it would come on when I set it, then disingage after a few seconds. After I repeated that a few times it finally would cut off completely and wouldn't come back on till I restarted the engine.
Thursday, December 1st, 2011 AT 5:39 PM