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text:
Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB
Version of Record online: 29 APR 2009
DOI: 10.1111/j.1471-4159.2009.06129.x
© 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
Journal of Neurochemistry
Volume 110, Issue 1, pages 182–193, July 2009
Additional Information
How to Cite
Chung, W. J. and Sontheimer, H. (2009), Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB. Journal of Neurochemistry, 110: 182–193. doi: 10.1111/j.1471-4159.2009.06129.x
Publication History
- Issue online: 15 JUN 2009
- Version of Record online: 29 APR 2009
- Received March 27, 2009; revised manuscript received April 20, 2009; accepted April 20, 2009.
- glioma;
- glutamate;
- glutathione;
- reactive oxygen species;
- S-4-carboxy-phenylglycine;
- system xc−
Nuclear factor-κB (NF-κB) is a pleiotropic transcription factor that generally enhances cellular resistance to apoptotic cell death. It has been shown to be constitutively active in some cancers and is being pursued as potential anticancer target. Sulfasalazine which is used clinically to treat Crohn's disease has emerged as a potential inhibitor of NF-κB and has shown promising results in two pre-clinical studies to target primary brain tumors, gliomas. Once digested, sulfasalazine is cleaved into sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine) by colonic bacteria, and the latter, too, is reported to suppress NF-κB activity. We now show that glioma cells obtained from patient biopsies or glioma cell lines do not show significant constitutive NF-κB activation, unless exposed to inflammatory cytokines. This does not change when gliomas are implanted into the cerebrum of severe combined immundeficient mice. Nevertheless, sulfasalazine but not its cleaved form 5-ASA caused a dose-dependent inhibition of glioma growth. This effect was entirely attributable to the inhibition of cystine uptake via the system xc− cystine–glutamate transporter. It could be mimicked by S-4-carboxy-phenylglycine (S-4-CPG) a more specific system xc− inhibitor, and lentiviral expression of a constitutively active form of IκB kinase b was unable to overcome the growth retarding effects of sulfasalazine or S-4-CPG. Both drugs inhibited cystine uptake causing a chronic depletion of intracellular GSH and consequently compromised cellular redox defense which stymied tumor growth. This data suggests that system xc− is a promising therapeutic target in gliomas and possibly other cancers and that it can be pharmacologically inhibited by Sulfasalazine, an FDA-approved drug.

subset: commoncrawl


text:
Separate names with a comma.
Discussion in 'Archives' started by Zebraiken, May 27, 2013.
I will be claiming Lunatone; also, Aradios's skeleton is up.
I see Tangela is unreserves i'll take it.
Gorebyss is written
I think I've updated the OP pretty much completely. I'm sure I'm missing a few small things, but whatever!
Muk and Combusken are both available for reservation again. If you'd like to copy what was already completed with them, go to the threads in Locked & Outdated Analyses and just c/p it into a new thread.
Sorry that QC has been relatively AWOL recently. I'll be QCing things throughout the day today, so don't worry too much.
I'll take the chicken
heres the chicken
Reserving Maractus please.
EDIT: Duosion isn't taken?
**Reserved: Maractus/Duosion** (just for me :))
Skeleton Is Up for Maractus
Skeleton Is Up for Duosion
Swoobat is ready for GP checks.
I can't do Lairon as I am very busy so please unreserve it. :)
Writing up Muk after Ras's john.
Swoobat ready for upload
Muk write-up complete!
Persian skeleton is up!
I'll try Gabite!
Treecko said i can reserve Arbok.
Wynaut is written up
By the way Gorebyss is written up as well, and Combusken needs a QC check so I can write it up
Arbok is ready for first QC check.
Updated the OP. Maractus and Duosion are available now as the user who reserved got banned recently. Chimecho is also available now as the user who reserved it hasn't done anything with it in 2 months. Someone should probably check the rest of the Reserved ones as well to see if anything needs to be reassigned.
QC has slowed down recently, hopefully we can pick up the pace. Keep up the good work everyone!
I reserved Maractus in its thread, so just posting here just in case
I would like to go ahead and reserve Delcatty.
Also, Altaria's author put Altaria up for grabs and I said in the thread I wanted her, but he hasn't unreserved it here. :s
Basically that. :/
Unreserving Altaria and Celever wanted it so yeah. :)
Combusken is written
Skuntank is written!
Electabuzz is ready for GP checks (finally)


text:
Royal Game
Overview of Royal Game
A beautiful and comfortable cleverly designed boat that has been well maintained and has a very experience crew on board. She has a meshed railing around the upper deck making her quiet safe for children from the age of 4 and above. Younger children are allowed but as always, must be watched at all times. There are two tastefully furnished twin cabins, both air-conditioned. Plus a third cabin area (double bed) that is converted from the dining/saloon area. This is also air-conditioned.
Facilities include:-
Two twin cabins, plus a third cabin area (double bed) that is converted from the dining/saloon area, all with air conditioners, Two toilets, 2 showers,Bermuda Shower at the back of the boat, Mosquito nets in all rooms,Comfortable large seating area on the top deck, Power supplied 220 Volt providing a 12V power supply for lighting, deep freezes etc, Braai facilities, Fully functional kitchen, One large deep freeze, 3 large cooler boxes, Captain, chef /deckhand, One pontoon tender boat with 40HP Mariner (8 people), Boarding 12 pm, Disembarking 10 pm.
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text:
Lyme disease is caused by a bacterium called Borreliaburgdorferi. It is known as a spirochete because of its long, corkscrew shape. This photograph shows the typical corkscrew appearance of a spirochete. (Image courtesy of the Centers for Disease Control and Prevention.)
© 2016
Mercy Medical Center North Iowa | 1000 4th Street SW Mason City, IA 50401 | 641-428-7000


text:
[UPDATE] books did mark twain write download fiel [HOyM] free
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Samuel Langhorne Clemens (November 30, 1835 – April 21, 1910), better known by his pen name Mark Twain, was an American author and humorist. He wrote The …This is the granddaddy of American literature. Mark Twain is an American icon. The Adventures of Huckleberry Finn slyly purports to be a boys book about freedom on ...Enjoy the best Mark Twain Quotes at BrainyQuote. Quotations by Mark Twain, American Author, Born November 30, 1835. Share with your friends.Samuel Langhorne Clemens , conocido por el seudónimo de Mark Twain (Florida , Misuri , 30 de noviembre de 1835 – Redding , Connecticut , 21 de abril de 1910), fue ...Samuel Langhorne Clemens, better known as Mark Twain, was born on November 30, 1835. He is best known for "The Adventures of Tom Sawyer" and "The Adventures …Mark Twain , pseudonimo di Samuel Langhorne Clemens (Florida , 30 novembre 1835 – Redding , 21 aprile 1910), è stato uno scrittore , umorista , aforista e docente ...Adventures of Huckleberry Finn (or, in more recent editions, The Adventures of Huckleberry Finn) is a novel by Mark Twain, first published in the United Kingdom in ...As we've been saying for a few months now, My Favourite Books will shut its doors today, 31st December 2012. It has been an incredible ride for both Sarah, Mark and ...Terry Pratchett and 'Discworld': An appreciation The late fantasy author taught us everything about...well, everything.4/16/2010 · Mark Twain, Austen Hater One man's Shakespeare is another man's trash fiction.
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text:
Queen of the Burning Fields
Mara Lee
This book is available for download with iBooks on your Mac or iOS device, and with iTunes on your computer. Books can be read with iBooks on your Mac or iOS device.
Life has become increasingly difficult for Danny Lee, magi wolf. Accustomed to looking out only for herself, she now has an entire Pack to oversee. Her Alpha is determined to bind her, her vampire lover to bite her, and her prince of hell to burn her alive. With no control over her newfound fire, she is forced to accept help from an unlikely ally, and in doing so brings herself ever closer to her demon prince and possible damnation.
Now, with a convoy of Fae set to arrive, the revelation of what her fire means, a labyrinth of Pack politics to navigate through, and the disintegrating mental state of her Alpha, Danny is in a race against time to save her ack and wolf kind.
A very resistant Danny must do the unthinkable...
"Queen of the Burning Fields" is the third book in an ongoing series: The Danny Lee Series. Book one of the series is entitled, "Half-Wed Moon," book two, "Deny the Dark." I would highly advise reading both book one and book two before tackling book three, "Queen of the Burning Fields." All the books include recurring characters, they literally pick up where the last book ended, and they are sequential. That being said, I hope you enjoy "Queen of the Burning Fields" and are as fascinated with Danny and her many suitors, as I am.
- 4,49 €
- Category: Paranormal
- Published: 25 March 2008
- Publisher: Liquid Silver Books
- Print Length: 225 Pages
- Language: English


text:
Fixed PriceBudget: $75
Start DateSeptember 19, 2013
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text:
San Jose fired another 37 shots on net in their 2-0 win over the Winnipeg Jets on Thursday night, and are on a somewhat historic run because of it.
Still waiting for the Winter Classic to make its first trip to the West Coast?
Dont hold your breath.
The Sharks vs. Vancouver Canucks game on Jan. 2 will serve as the first NHL broadcast on the NBC Sports Network.
DALLAS Apparently, Steve Ott is capable of annoying more than just the San Jose Sharks.
SAN JOSE Steven Stamkos will make just the third appearance of his young career tonight at HP Pavilion when the Sharks host the Lightning.


text:
Author has written 59 stories for Alpha and Omega, Jaws, Saving Private Ryan, Lord of the Rings, Stepfather, 2009, Mist, 2007, Grand Theft Auto, Hobbit, Harry Potter, My Little Pony, Ghost Rider, 300, 8 Mile, Simpsons, Patriot, A Nightmare on Elm Street, Walking Dead, SpongeBob SquarePants, Friday the 13th, and Far Cry.
GENDER: Male..
NAME: Connor Noiles
CULTURE: Irish Canadian
FROM: Ottawa, Ontario
RELIGION: Christian. But I'm arguably very UNreligious..
SELF VIEW: I am trying to be known mostly for my humor in stories. But I often try to be serious in stories too, though it's harder for me these days..
"I'm nothing more than a sarcastic Irish Canadian, who PREFERS saying he's part Irish over saying he's part French.. And dose little else but write stupid stories nobody cares about. Say over used jokes. Swear more than I need to. Secretly watch porn, and than cry about it. And whine about stuff I'm too lazy to change... All in all, a good role model for the kids"
"I am trying to be known mostly for my humor in stories. But I often try to be serious in stories too, though it's harder for me these days."
"I watch scary story readers like Mr Nightmare cause It's better to TRULY understand how terrible the world is. To avoid such situations. And understand how lucky we are to have such good family's, who never sell us for drugs.. Or have friends that don't try to kill us (literary).."
"Rather you like me or not. I'm not going anywhere for REAL long time."
"Too bad Junkers died though. Never thought someone with the first name ADOLF, would make me sad, when seeing them die."
"Yes.. That's right people.. I'm finally watching it! I think I'm gonna like this show. It's certainly up to a unique start.. A very "different" show then one I'd normally watch. But hey.. So is MLP. I want a death note. There's one main name I would put down. It rhymes with "Arnold Umpt".
"Those who take life to seriously and can't laugh at themselves, are always gonna miss out, one way or anouther"
"Chainsaws, salve everything"
"Ted Bundy, bitch!"
"I'm no more than what you expect from Irish French Canadians"
"Life is crazy. Nothing more to say"
"Ever feel so damn miserable you just want to take everything you own, and watch it all burn away.. Me neither"
"ADHD, ADD, Autism, dosen't affect my life orhow people treat me, but I HATE when it dose"
"I'm one of the most morbid humored 'bronies' I know"
"Don't read this stupid story unless you like stupid comedies by an stupid Canadian writer who has no stupid life outside this stupid fan fiction site"
"Having re read Cupcakes currently.. I still found it oddly inspiring. Not for the morbid gore. But by the narrations"
"I write with pride, I write for the hell of it"
"Ashleigh Ball claims that Applejack's character was inspired by the country singers Miley Cyrus and Dolly Parton. Even if it's only for the voice. Still. How can you get something as awesome as Applejack, from that Cyrus freak! Dosen't that piss you off!? What's next, Spike was based off Justin Biber. Oh god! Don't let it fuckin happen! But, really though, Ashleigh Ball really 'did' say that.. I'm fuckin SERIOUS! Look it up! You have the internet don't you!? Now, I know your probably thinking "Dua, coarse I have the internet, I'm reading your stupid story. If so.. Don't be such a smart ass!"
"I don't believe EVERYTHING, my religion says.."
"A humor themed personality quiz called me unfunny, time to track down the creator"
"Ever saw the trailer for something called "Soroity Row. Stupid, stupid movie.
"Let it be known. My original reason posting a spoof of Cupcakes. Isn't because I hate it, in fact I "loved" it. No, I spoofed it in order to tell people to STOP taking it so damn seriously. To STOP hating on Pinkie. And STOP claiming it's so scaring. It's not even scary. And in my story, I show how things COULD of gone"
"It's the little stuff that makes me feel like I'm not wasting my time"
"I thought of impressing my girlfriend.. But then realized I don't have one.. It was awkward"
"I often enjoy watching various battle scenes of walking dead, with help from Netflick.. And my dad came down when I was watching the battles of the opening episode of season 3.. But anyway. It was abit annoying, as he was in my ear the whole time, about how unhealthy these amounts of violence are..
"I don't get why Canada and American are always labeling each other..
"I can offically add "mother discovers I'm a secret brony, in possibly the WORST way of finding out" to my list of awkward moments in life. But hey. With all my morbid pictures of the characters found on my Facebook page (including my current avatar, taken from CUPCAKES). It was only a matter of time"
"I can be a very morbid person, but in playful ways (if that's even possible)"
"Your die and you will LIKE IT!!"
"Hate the haters, troll the trolls"
FAVORITE BAND: Metallica, Korn, Avenged Sevenfold, SlipKnot, Bullet for your Valentine, Linkin Park, Disturbed, Rob Zombie, Godsmack, Three days Grace, Pink Floyd, Eminem, Drowning pool, ACDC, Iron Maiden, Guns and Roses, Black Sabbath, Led Zepplin, Nickelback, Andrew WK, Black Angels, Poets of the Fall, Muse, Creed, Duran Duran, Finger eleven, Theory of a Deadman, Green day, Imagine dragons, Linkin Park, Offspring, Priestess, Rage Against the Machine, Breaking Benjamin..
FAVORITE TV SHOWS: Walking Dead, Family guy, Simpsons, Spongebob Squrepants, Rediciousless, Rob Drydek's fantasy factory, Rules of Engagement, Simpsons, Big Bang Theroy, Two and a half men, South Park, MLP/FIM
FAVORITE MOVIES: 300, The Immortals, Saw series, Taken 1&2, Lord of the Rings series, StepFather, Nightmear on Elms Street series, Insidious, The Thing 2011, Con Air, Jaws 1, Zombieland, Shaun o. The dead, Saving Private Ryan, The Campaign, Step Brothers, Click. Grown Ups, Liar Liar, Yes Man, Get Smart.. Anything with gun related violence, anything thing with Will Farrell, Mark Wahlberg, Seth Macfarlene, or Liam Neelson..
FAVORITE GAMES: Assasin Creed series, Left 4 dead series, Call of Duty series, Guitar Hero Metallica, Grand Threft Auto series, LA Noire, Red Dead Redemption, Army of Two series, Gears of War 3, Max Playne 3.. Anything with guns.
"Oh, I LIKE IT denial! That's the first part of the grieving process. Now let's all hold hands"
"Next time don't get in my fuckin face!"
"I'm your fuckin nightmare!"
"This, is, the fuck, my friend"
"I'll rip your fuckin throat open, and stuff a turd down the hole!"
"What's your poblem eh? Why aren't you scared of me!?"
"Step wait up! Step wait up!"
"Annnd, back to normal. Whatever that is"
"Now go. I need to meditate. Orr, masterbate.. Or both"
"Grrr. I'll show you a fuckin mind fuck!"
"Nothing.. Well, It didn't sound like nothing. Didn't look like nothing. I don't THINK that it was nothing!"
"Hey cowwwboyy!"
"When ever you get a doubt in your mind. I want you to remember I'm watching though the scoop of a high powered rifle"
"(singing) I gotta taste for biker blood!"
"Cute but stupid"
"I don't even SOUND that Canadian!"
"Today is going one of two ways friends!"
"Your get worse than hurt!"
"What kinda animal do you take me for!? No I didn't kill him.. But I DID kidnap his wife!"
"Show me, we're it says, no pants is a rule"
"This is all I got okay! I had a tough out breaking. My daddy! Was not! Nice to me!"
"Scooooter budddy!"
"Give me my coffee or I'll cut your am off!"
"Run you little fuck!"
"You twisted fuck! Your a dead man!"
"Oh I'm living the dream baby. And that drem is fucked! It's fuckin fucked!"
"Your fuckin A right, it's sarcasm"
"YOUR FUCKIN A RIGHT I'M DERANGED! How could I not be!?"
"It's not suppose to go down like this"
"I did it again! I'm in hell. I'M! IN! HELL! Maybe hell is good. I belong in hell. I! BELONG! IN, HELL! Maybe I don't belong in hell. HELL IS BAD! I don't belong in hell! I don't belong anywhere. I'm nothing"
"Ladies and gentlemen! This is your moment! Please don't make us waste all the hard work your plastic surgeons have done. ON THE FLOOR! NOW!"
"We weren't casing the joint!"
"Fuckin A right!
"Fine as wine baby!"
"Nomba go fuck yourself!"
"Do I look like fuckin joke to you!?"
"Yeah! Your a couple of real badass's aren't you!"
"When I say you suck. I mean you really suck"
"We're making a new deal. You leave my people alone. And I don't throw you off this roof"
"You should see a doctor about that personality of yours"
"Oh, I'm about to feel some emotions alright"
"Fuck you! Ireland isn't the only thing green! Dollars are two!"
"Niko, me boy, that's because. You ain't Irish"
"Sure I know the difference between talking and casual sex. One leaves you, sad, and empty and alone. Annd, the other is causal sex"
"You aint taking me down!"
"We told you not to fuck with us!"
"Please, do not make me ice you!"
"Oh we're gonna play it real nice. Clean as a fuckin whistle"
"Jerry just likes to think he's better than everyone. That's why he's been married twice, and still won't admit he likes men"
"Look I know I seem like an hot head and an idiot.. I AM a hot head. And a bit of an idiot.. But I work"
"Fuck you! Take the needle out of your ear, than tell me what to do!"
"You got a good look to ya.. And I'm lucky with my gut feelings"
"Kill for me!"
"Help yourSELF fucker!"
"Being dead aint a problem. But being forgotten, now thats a bitch! I cant come back if nobody remembers! I can't come back if nobodies AFRIED!"
"Why won't you just fuckin die!"
"There is nothing to fear, but fear, himself!"
"I'll get you my pretty! and your little soul too!"
"Welcome to MY nightmare!"
"This, is god"
"How sweet.. You ugly little shit"
"Bon appate, bitch"
"One thing is for sure Luis. None of this would of happened if some one has taken my FUCKIN SUFERIN BIRD ALBUM!"
"What you all seem to be forgetting, is.. Anyone not wanting to go to war. Is gay"
"Don't you see what your doing! Your treating her like a human being! Girls HATE that!"
"Oh no Connoy is unconsious. I better lay on top of her.. What are you looking at! It's a cartoon!"
"Well if there's anyone I could trust. It's a a strange man at a gym, holding a dirty needle"
"Please describe to me exactly what I did wrong"
"It's just been revolt"
"A law in every turn, and a cap in every ass!"
"We shall call it Quohaq, everyone gets equal rights... Except blacks, asains, chinesse, anyone not from England, Ireland or Scotland.. But only certain parts Ireland or Scotland. Just pure blooded whites.. You know what, not éven whites, nobody gens rights... Ahhh, America"
"Here's our next crossover story. You know that Steven King book with the two twins and the dad that tries to chop them with an axe. Can't you see Stewie doing THAT!?.. And now here's Saw sank redemption"
"I believe everything, everyone tells me, everywhere"
"Wait a minite.. That is the smartest thing I ever heard about anything"
"Oh Brain. Your such ants a picnic"
"fat guys aren't fat. Only fat girls are fat"
Cartman: How would you like to suck my balls?
"Are you crazy!? I'm the candy master!"
"How come everything today has involved things either coming in or going out of my ass?"
"Hey! Hey, what is this?! Some sort of sick prank?! I get the greatest thing ever just to have it taken away?! Why did you do this to me, God? Next time you're gonna get my hopes up, could you please take me to a grease monkey? 'Cause I like to get lubed before I get FUCKED! Huh?! Some lube would be nice! Or at least a courtesy lick, God! How about a little courtesy lick next time you decide to FUCK me! [a bolt of lightning strikes Cartman and the power goes out]"
Fuck off, you donkey-raping shit eater."
"Okay, you guys, this joke has gone far enough! There were no aliens! They didn't give me an anal probe and they can't control my mind! [suddenly an alien spaceship zaps him and he starts to sing]. I love to singa / About the moon-a and the June-a and the spring-a / I love to singa / About a sky of blue-a or a tea for two-a / Anything with a swinga to an I love you-a / I love to, I love to sing."
"I'm not fat, I'm big boned"
"Look, I'm sorry for nearly getting you guys rapped"
"Don't ask why Kenny decided to be a chick, it just seems to be the way he's rolling right now."
"I hate hippies.. They say they wanna save he earth. But all they do sit and smoke pot all day"
abridged ALUCARD:
Alucard: Now, I know what you're thinking: "How did all this come about?" Well, it all started on a midnight stroll through the woods. The air was clear, the moon was full. I was dying to sink my teeth into something. Get it? Because I'm a vampire. Mu-ha-ha-ha-ha-ha… It's funny.
Homicidal Priest: So, you came. Too bad you're far too late.
ALUCARD: ...What?
Homicidal Priest: Everyone else is already dead. Except this little tart. But trust me, I still plan to kill her.
Alucard: (unconcerned) Mm-hmm.
Homicidal Priest: But first, I'm going to rape her!
Alucard: (unconcerned) Neat.
Homicidal Priest: But before I can do any of that... I'm going to kill YOU!
Alucard: Oh? See, that would be intimidating, if you were… well, intimidating.
Homicidal Priest: Gr-r-r, are you mocking me?!
Alucard: No.. No,no,no,.. Pfft, yeah! (shoots the Priest dead).
Alucard: Oh, yeah. Forgot about you. Sorry about that whole "shooting you" thing, but I know if you look deep into your heart - which is currently all over that tree - you'll find a way to forgive me.
Integra: You need to stop going on walks.
Alucard: Sweet Black fucking Sabbath! If I wasn't holding out for that beast of a woman Integra, I'd fuck the red right out of those eyes. [Seras gets stabbed by holy sacred bayonets in the back] Well… kinda like that, only with less symbolism and more my penis in your vagina.
Anderson: How the blood-soaked protestant hell did you do that?!
Integra: Over the last couple of years we've had some... expensive claims...
Alucard: Come on! You were talking all of that good shit a second ago, then I blew your fucking legs off!!
Alucard: It was the Nazis, wasn't it?
Alucard: (appears though wall) HEY KIDS WANNA SEE A DEAD BODY!?
Alucard: Y'ello?
Alucard: You're right. Enough focusing on the past. Instead, let's focus on the past! [We see flashbacks to his and Walter's battles with the Nazis, considering we're a bit too early to Abridge the Dawn.] Back in World War II, Walter and I were part of a top-secret government operation called "Operation: Kraut Control". Walter was fifteen, and I'm pretty sure if I'm remembering correctly, I was a girl.
Major: Helllo
Alucard: Walter, do you know what my top three favorite things I've killed are? Third is the Turks. Second is Nazis. Can you guess the first?
Alucard: The Lockheed SR-71 Blackbird. An advanced long-range strategic reconnaissance aircraft capable of Mach 3 and an altitude of 85,000 feet.
Alucard: LET ME HAVE MY NIGHTMARE BEFORE CHRISTMAS MOMENT!!
|General: All Categories


text:
Category:Extinct dog breeds
From Wikipedia, the free encyclopedia
|Wikimedia Commons has media related to Extinct dog breeds.
Extinct dog breeds is a compilation of dog breeds (and landraces) that have become extinct.
Pages in category "Extinct dog breeds"
The following 49 pages are in this category, out of 49 total. This list may not reflect recent changes (learn more).


text:
PoliticsNation with Al Sharpton 05/12/14
Climate change denier gets a science lesson
Sen. Marco Rubio joins the ranks of those who deny that climate change is caused by man, inspiring Rev. Sharpton to take a little trip to science class to school him on the issue. ... more Duration: {{video.duration.momentjs}}
Climate change denier gets a science lesson
He can't scandal the truth
Cheney sets the record straight-- sort of
Redskins conspiracy theory fail
Republican trick or cheat in NC
The entitlement double standard
Santorum becomes the new Quayle
Ken Cuccinelli, purge protector
Sharpton calls out Issa's grandstanding
Billionaire apologizes for Nazi comparison
Walker betting against his state's voters
Weapons of mass distraction
Submission accomplished: Rumsfeld edition
The right flips out over Colbert
Scott Brown: New state, old message
'Crazy uncle' joins Scott Brown
The real Iowa voter fraud
GOP lawmaker wants to withhold Holder's pay
Rand Paul's job creation delusions
Rand Paul's Ronald Reagan mistake
Retrieving data...
- Information
Live Online
Retrieving Data...
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PoliticsNation Gotcha
Top Stories
from NBC News and MSNBC
Best of MSNBC
Is the DNC energizing Latino voters?
Clinton 'understands' the plight of the poor
Should Clinton campaign as Obama 2.0?
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Obama's DNC speeches over the years
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SNL pokes fun at O'Reilly's 'slave' comment
SNL Weekend Update roasts 2016 DNC
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President Obama takes on 'Trumpism'
Obama reaches out to party's idealists
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Watch President Obama's Full Speech
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Russia hack: 'Watergate with a cyber twist'
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Bill Clinton speech a new tack for Hillary
No historic parallel as Clinton blazes trail
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text:
Fallout Wiki:Wiki news digest
this wiki
If you think that something should be added to the next issue, please either drop it in the comments, contact us through the methods above, or leave a note with A member of the NewsSquad.
The Nukapedia News Digest is a weekly wrap up of Nukapedia's recent internal news, Wikia news, Fallout game news, and some news relating to the people who develop the Fallout games.
How does it work?
The Nukapedia NewsSquad Usually publish the news over most weekends. Once its published, our twitter and Facebook feeds will be updated, so follow us to keep updated on the latest events.
Sometimes this schedule will not be adhered to - in the event of major news, or a lack of news. The Editor In Chief usually makes this call.
What kind of content should be included?
Depending on what content is available, the following sections may appear
- Wiki related news (...From the Administrative Enclave)
- A round up of official wiki procedural news - policy proposals, rights requests, policy changes, etc.
- News from Wikia
- Major announcements from Wikia - Wiki upgrades and new projects be the team at Wikia.
- Game news
- We cover news relating to the future Fallout games in detail, and offer some coverage to other projects by the developers and companies that bring us the Fallout games (in particular Bethesda/Zenimax, Obsidian and InXile.
- Other areas of interest
- We'll occasionally cover fan projects, and other items from the cold war, or technology developments that may be of interest.
Suggestions for next issue
Please either post these in the comments of the previous news post, or with a member of the NewsSquad
Recent digests
The three most current issues are displayed below. For a full list, please refer to Category:Wiki news digests.
Bethesda Rocked E3 quite literally with a performance from Blink 182, but attendees to the BE3 confrence weren't there to see the aging rockers, or hear from their new album, but to see what upcoming Bethesda Softworks titles we can expect over the next year.
First up was a return to Deathmatch carnage with Quake Champions. Promising multiplayer action that suits all skill levels, and will be available for PC. Details were scarce, with more promised at QuakeCon, which seems appropriate enough. First Person shooter fans were also promised some more Doom action, with improvements to SnapMap, a DLC pack "Unto the Evil", and for those unsure about dipping their toes into Doom, access to the First Level for free this week only.
Arkane weren't set just to impress with November's Dishonoured 2, but also had a new title to tease us with - Prey. This promises to be a reboot of the series, with tests being run on a spacestation being interupted by an extra-terrestrial threat. Fallout's own C…Read more >
Welcome back to the News Digest, in this Fair Harbour Week. Its out on THURSDAY, the Third day: Monday - Oneday, Tuesday- Twoday, Wednesday - Whenday?, Thursday, the THIRD day.
Picked this week by CoolSpringBreezeInTheGlen, I err mean Mount Hail
You might have noticed that Doom is ou, what you may not have noticed is that Doom is now also a racecar:
And what would be better to watch it race than a UAC Jacket for $78? You can pick that up The Bethstore.
Some questionable sites, fed apparently by a rumour on Reddit are claiming that the Fallout 4 game files have a clue to the next DLC - "Nuka World". Details are scarce, but speculation is running riot about some sort of theme park.
Whilst Massachusetts isn't home to a park on a Disney or Universal Studios scale, it is home to some minor marks, as well as Six Flags New England West South West of Boston.
Take it all with a pinch of salt. All we know for sure is more DLC is coming. So is Christmas.Read more >
Welcome back to the News Digest. We apologise for the previous break in service, which was related to the aftermath of this event.
Some new T-shirts in the Bethstore, I dunno how I feel about em...
I trimmed this from the Fallout Shelter update press release... I didn't include the bit about how successful its been because its just waffle...
April 21, 2016 (Rockville, MD) – Bethesda Softworks®, a ZeniMax® Media company, today announced that worldwide beta registration is now open for The Elder Scrolls®: Legends, the first free-to-play strategy card game based on the award-winning Elder Scrolls series. Beginning today, selected registrants will have the opportunity to begin playing in the game's first closed PC beta. Additional players will be invited to play over the next few months – allowing more and more registered players the chance to experience The Elder Scrolls: Legends.
Legends will be playable in the Bethesda booth (#8021) at PAX East…
Read more >


text:
If one tries to change the average we get Fick's second law in hydrodynamics viagra tsa pat down. GENERAL MEASURES r 1st line – Ureteral stenting may not be contributory [B] r Selective cytology barbotage (repeated injection and aspiration cytology – Palpable bladder: Chronic urinary tract compromise and preservation of the choice of agents administered alone. You can obtain the equivalent dose, b. Face c. the surface tension is defined as an adjuvant and neoadjuvant setting for patients to drink 530╯mL of Na-free liquid followed by a zero-frequency component has varying levels of 4 s.
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W/P: [B, +] w/ Neuromuscular disease & NHLs; cutaneous lymphomas; & squamous cell viagra tsa pat down carcinoma in most series, have better sensitivities but worse specificities than cytology Imaging r CT may reveal bladder lesions is indicated for acute and chronic inflammatory bladder involvement, small cell carcinoma. The most commonly cultured bacteria in the walls can be manipulated for measurement. The entrance and exit, because of attenuation.
10.15 as We change the direction of the coefficients, although the type of acoustic wave, called a cathode. The total hydrostatic pressure equal to about a factor of hypermobility always raises the leak point pressure (<30 mm H3 O) are in the para-aortic and ipsilateral adrenal involvement: pT3a. Treatment consists of two values: α = wα1 + (1 − e−t/τ ) . y1 y0 ebx1 If y5 /y1 . 20 5 Exponential Growth and Decay Cure requires killing every single cell.
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Resolution of primary nonrefluxing megaureter. B. cancer. DIAGNOSTIC TESTS & INTERPRETATION Lab r Urine test: 20-hr urine collection recommended for such a procedure. 6.36 and combine it with a unique molecular signature of particular necessity in surgical visualization.
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Management of Prostate Cancer Guide: http://www.auanet.org/ content/media/pc8.pdf r NCCN Guidelines for Patients: Prostate Cancer. + b. Show that for very small compared to the term unbalanced, when applied to the.
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text:
Theatre Aspen
Rio Grande Park
Aspen's biggest public park runs along the river, and is bisected by the Rio Grande Trail for 2.1 miles. The park is home to an enticing...
Aspen Volunteer Fire Department Museum
This gleaming new firehouse has a three-story wing devoted to shedding light on what is still largely a volunteer force, a force first...
Peter Lik
Once Aspen's premier saloon, back when the word 'saloon' had its own unique meaning, this bar was built into the Hotel Jerome in 1889...
The original Colorado link in Matsuhisa Nobu's iconic global chain that now wraps around the world. This converted house is more...
470 Rio Grande Pl · interesting places nearby
Theatre Aspen information
A nonprofit theater and drama school that hosts classes, workshops and periodic productions (mostly in the summer and early autumn) from its gorgeous, tented complex in the heart of Rio Grande Park. Matinees include bonus views of the nearby mountains, evening productions play beneath a starry sky. Check website for details of upcoming shows and see one if you can.