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InFocus Pro - Calendar, To Do, Notes & Projects All-in-One Organizer
By Elixir Software Group Inc.
Open iTunes to buy and download apps.
Five Productivity Tools in one, for easier and improved productivity. InFocus Pro comes with indispensable tools for staying organized so you can get things done quicker and have more free time to do the things you love.
Great for work, school, shopping, organizing events, planning a vacation and organizing your daily life. Highly flexible so you can choose the way you want to organize yourself, from a simple checklist, to a more complex project with to do's and notes. With InFocus Pro, you are in control!
Limited Time Offer at this price, so download InFocus Pro now!
5 Apps All-In-One:
• Calendar
• Checklist
• To Do
• Projects
• Notes
• Be unique & personalize your Calendar with your own background image
• List, Day, Week & Month View for greater flexibility on the style you like
• Set alerts so you don't forget an appointment again
• Set repeating events so you can easily create multiple events without any extra typing
• Add Notes to your Calendar so you can be better prepared for you appointments
• Use Apple, Google, Yahoo Calendars and have them sync to these accounts so your always connected
• Handwrite your calendar event for quicker entry
• You can listen to your events with text to voice so you can be hands free
• Share your events with your co-workers, colleagues, family members or friends
• A simple checklist which allows for quick entry
• Organize by project so you can be more efficient
• Set an alert to your checklist item so you don't miss important things to do
• Hold and drag your list items so you can re-order your list fast
• Listen to your checklist items with text to voice so you can be hands free
• Handwrite your Checklist item for quicker entry
• Share your checklist with your co-workers, colleagues, family members or friends
• Integrates with To Do & Projects module so no need to retype your entries
To Do
• A structured to do list for more precise organization
• Add a priority to your to do's so you know what's important
• Assign a project to your to do for enhanced organization
• View your to do's with a variety of organizational tabs for more efficient viewing
• Set an alert to your to do's so you don't miss anything important again
• Add a start and end date which helps you keep track of start and completion dates
• Listen to your to do's with text to voice so you can be hands free
• Handwrite your to do for quicker entry
• Share your to do's with your co-workers, colleagues, family members or friends
• Integrates with Checklist & Projects module so no need to retype your entries
• Color code your project folders so you can be more efficient and you can easily find folders
• Add a priority to your Projects so you know which projects are high priority
• Add subfolders to your projects so they are easier for you to view and for more advanced organization
• Add to do's and notes to your project which allows you to have more powerful and advanced project organization that can handle all your projects
• Share your projects with your co-workers, colleagues, family members or friends
• Integrates with Checklist & To Do modules so no need to retype your entries
• Add text, handwritten sticky notes, pictures and sketches to your notes which allows you greater note taking abilities
• Assign a project to your notes for advanced organization
• Handwrite your note title for quicker entry
• Share your note by email with multiple formats (JPG, PDF) so your note is accessible by almost anyone
• Save your note on your Photo Album for more flexibility in sharing
• Password protect your app so your important things stay secured
• Backup your data to iTunes for added security so don't need to worry about data loss
• All modules have search capabilities so you can easily find your what your working on fast
What's New in Version 3.2.0
- Added Touch ID
- Show "Fixed" Date & Time only for iCloud Calendars. Other Calendar do not support it.
- Fixed Month View from adding duplicate events in the tableView after entering foreground
- Fixed Calendar Event note so that multiple line notes show on event details.
- Add Version number to Setting
- Fixed Repeating Events
- Allow Music to keep playing in the background
iPhone Screenshots
Customer Reviews
One of the best apps out there.
This is a great organizational app and is worth a download. It has some very unique features different form other apps. Under a project, you can create sub-projects. Each project/sub-project can have tasks, notes, sticky notes, and photos. This was very helpful when I was planning a large home improvement job. I was able to break down what needed to be done into smaller projects (prep, actual work, clean-up), each with it's own set of tasks, notes, photos, etc. so that everything was organized. I think the imbedded photos for a project is a GREAT idea. I didn't use the sticky note too much, because my writing is terrible on-screen, but the function works very well.
The only thing this app doesn't have is context tagging (or at least I couldn't find it). I've been using another app where this is available and I find I use it a lot. The other thing I don't like about this app is how it looks. At first I thought I would like it since it has a very familiar folder-tab look to it. But after using it for my project, I found that when I expanded a project file, it was visually confusing for me. I'm not knocking any stars from this app as these are two minor quibbles that don't affect the quality of this app.
Review by a real user
I'm baffled by the glowing reviews. This is an app that has some future potential but still needs a lot of work. The 3 major failings are: 1) it is portrait mode only, many of us like to prop our iPads open in landscape while using business-type apps. 2) no cloud or other file sharing only the ability to send archaic emails, that's the kiss of death for any organizer app. 3) lack of consistency from function to function, the settings are all different and there are no global settings. This app right now is still in its early basic stages, I hope the developer keeps working on it and making it better.
Good so far
They a keep asking me for a rating and I want to just not right now. So far so good. Not many calendars can search or are as pretty and I use the iPhones icalanadar so much it won't let me edit at times but this one does (most do bc I have tried a lot of calendars but they don't search and this one does)
Would have been 5 stars if it would have given me more time to rate and I have a ton of apps and only a hand full of ratings so that should say a lot for this app.
Customers Also Bought
- $3.99
- Category: Productivity
- Updated: May 18, 2015
- Version: 3.2.0
- Size: 20.2 MB
- Language: English
- Seller: Elixir Software Group, Inc
- © 2015 Elixir Software Group Inc.
Compatibility: Requires iOS 7.0 or later. Compatible with iPhone, iPad, and iPod touch.


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3192 posts tagged with Health.
Displaying 451 through 500 of 3192. Subscribe:
It's experimental? Since when?
Questions around experimental procedures, health insurance, incommunicative doctors, and trying to advocate for someone who resists advocacy. I've broken down my big questions with some supporting info below. [more inside]
The air at the Dead Sea
It's my understanding that the atmosphere at the Dead Sea has a higher concentration of oxygen than the sea level norm because of the extremely low elevation (roughly a quarter mile below sea level). My question is: what does it feel like to breathe this air? Is it refreshing? Does it feel thicker than air at sea level? Are there any objective medical findings associated with long-term exposure to oxygen at this concentration? Many thanks in advance.
Where can I find up to date, quantitative studies on diet and exercise?
It's a new year and there have been a lot of articles about diet, nutrition and exercise around the internet lately. Most seem to be based on hearsay, personal anecdotes or scientific studies of extremely small samples - as do most Google results when I try to search for a current 'scientific consensus' on what a healthy diet and exercise program looks like. Can any one point me towards an evidence backed report that covers these topics and is accessible to a layman?
Registered nurse vs physician assistant
Hello. I need your opinion on going back to school. I currently work in healthcare in a hospital lab as a technician. I make good money don't get me wrong but I would like more responsability, more clinical diagnosis and treatment related job. I want to interact with patients and be a more important person than just a lab tech. I am thinking nursing school or physician assistant school. Please tell me the reality on the field, which one job gives you more satisfaction: pa or rn?i am 27, almost married,no kids, no house. I have a bachelor in biology/ medical technology. Do you think the rn to nurse practitioner is a better option than the physician assistant?
Help me find hope that things will get better
Things just keep getting worse and I don't know what to do. Please see extended explanation. [more inside]
Help me help my disorganized family member
I have a close family member who I am somewhat estranged from. But he has some needs that I have the skills to help with, and I want to help. Help me help him. [more inside]
Any tips on how to eat less?
I would like to start eating less. [more inside]
What to do to heal from a cough?
In week 4 of a cough they say I just have to wait out. What can I do to speed things along here? [more inside]
In sickness and in (better) health
My wedding is coming up in a few months and I want to find some small things I can do to reduce my spare tire before I walk down the aisle. [more inside]
When is it appropriate to ask about someone's health?
A friend of mine (let's call her "Sarah") came over for dinner at my flat last week. Some way through the meal (just after the first bottle of wine was finished) she told us that her partner had recently been tested for a very serious medical condition. She then said that she "hadn't intended to talk about it". She will have recently received the results of this test, and I'm wondering whether it's appropriate to ask her what the result of the test was. I care a lot about Sarah and her partner (who is an incredibly warm and wonderful person), but I don't want to intrude. On the other hand, I don't want to be unsupportive. A few details are below the fold. [more inside]
$3100 bill for "completely covered" procedure.
My doctor sent me for a colonoscopy due to family history. The clinic gave me some paperwork saying it would be completely covered unless they found something, and then it would be $250. They didn't find anything. I lost the paperwork. Now they're sending me bills for $3100. [more inside]
I need health insurance and MassHealthConnector is broken
Hello all, I was laid off from my job in July and went to Europe for a few months. Now that I am back in USA, I tried to sign up for affordable care act via www.mahealthconnector.org/ only to find out this site is the reincarnation of the devil. I cannot finish my application for this health insurance because I get stuck on a page that requires me to put in my employer info. Now since I am unemployed I obviously do not have an employer. This site literally will not let me complete the rest of the application without entering a whole bunch of information on my current employer which does not exist! How on earth do people without jobs apply for this?? Does anyone else run into this frustrating issue? Is there any other health insurance I can sign up for?
Is this acid reflux? Is this heartburn?
YANAD - but I went and saw a doctor and I'm still a little confused about things! The medication isn't helping and the symptoms aren't "standard", so is this reflux or something else? [more inside]
I'm stuck and not sure how to do life.
I am lost on how to proceed with my life/diet. Because #1 - There are many positives to eating strict #2 - There are many negatives to eating strict. [more inside]
Healing your inner child after childhood neglect. What helped you?
I have long-running case of depression and generalized anxiety disorder, with plenty of childhood triggers. I do see a therapist but due to the holiday schedule, I won't be seeing my therapist for a few weeks. I want to do some work by myself, because crying to sleep nearly every night is getting exhausting. I want my subconsciousness to chill out and be less triggered. I want tips, stories, and resources. Difficulty: I live with my parents, and I get triggered by them. [more inside]
I don't want to have to go to Dr. Oz or Andrew Weil for this one.
Which healthy grocery items/nutritional supplements/dietary interventions have you found to be worth the splurge, and how/why? [more inside]
Seeking a decent psychiatrist <1 mile of Farragut North or West
Can you recommend a decent psychiatrist in DC, within a 1-mile radius of either Farragut North or Farragut West (i.e., near K Street NW)? I have Cigna, however I am willing to go out of network. Thank you in advance. [more inside]
Suggestions on how to forget forgetting?
I have a tendency to automatically dissociate from/"forget" things that are stressful or anxiety-provoking. How can I better focus on these scary things so that I can better address and resolve them? [more inside]
Health insurance conundrum
I am totally paralyzed with indecision about the health insurance options I have at work this coming year. Halp! High deductible plan with an HSA vs tried-and-true HMO. [more inside]
I might finally come to be worth something to society! Maybe...?
Hi Mefites. I'll be starting an online medical coding and billing course in January ( given by the AAPC), after graduating from a relatively well respected state school with a psychology BA in May and finding out far too late in the game that it would leave me with nil in terms of job prospects. After building up quite a bit of credit card debt and deciding that man cannot live on Hulu and Facebook alone, as I've been doing for six months, I decided to look into opportunities that required relatively little training to get started with, and happened upon medical billing, something that seems to fit me quite well. I'm tempering my enthusiasm however, because no amount of Googling seems to give me a clear sense of my path once the course is over. Help? [more inside]
Daily Failures In Hydration
I am a grown-ass woman who fails utterly at hydrating herself. I would love any and all suggestions to help me drink more water regularly. [more inside]
I need a review or overview of nursing quality indicator systems.
I am on the hunt for a review, overview, listing of, or any other compilation of sorts that you may find explaining all the different American quality indicator systems in health care, specifically nursing if you're that good. AHRQ, ANA, NDNQI, .... but a more inclusive list and description of all their individual quality outcome management recommendations. I've been searching for days and haven't really found exactly what I need or want. Thanks!
Am I prediabetic?
Should I be concerned about my recent lab results? [more inside]
How do I get reimbursed for out of network health expenses
I have had quite a lot of medical expenses this year - much of it not covered by insurance. I will speak to my accountant about tax write offs. Is there anyway to get reimbursed for any of the following out of network: blood tests (expensive tests) phone consultations dr visits vitamins travel time Thank you in advance
flipped out!
How do I get better at not ignoring all the positive emotional work I've done when suddenly being triggered in a high-stress low-functioning situation? [more inside]
Please help me find a wellness escape where I can recover (East Coast)
One of my oldest friends just died and I'm feeling serious Crohn's pain starting to creep up again, threatening my remission. Everything in my life right now is stressful and exhausting, and I know that if I do nothing I will have a full-bore flair on my hands by thanksgiving. I need help finding a health resort/ wellness retreat on the East Coast - optimally between DC and Boston. My wealthy uncle says money is no object, so my only real stipulation is somewhere that isn't too scary/isolated for a young woman alone. [more inside]
Running Every Day... What do I need to watch?
Basically, complete the following sentence: "Now that you're exercising all the time, you should_______________________." [more inside]
What exercises can someone with cervical disc herniation (c3-c6) do?
After a nightmare MRI experience sometime in 2011 I found out that I have a cervical disc herniation on c3, c4, c5, c6. The pain was so severe that I was unable to move my neck to right side without feeling like I was going to pass out. Now that I've gotten my first coritsone shot and feel alive, I would love to work at gym on strentheting my cervical discs so I can beat this problem and avoid having to marry cortisone shots for the rest of my life. What are some excercise machines and workouts I can safely use to strengthen my neck without damaging it further? [more inside]
How can I best help my depressed friends & also take care of myself?
I watch many people who I care a lot about suffer from depression. I would sincerely do anything to help them, and do whatever I can think of: conversations, little notes and random texts, hanging out, offering help with thinking through options if they want it, etc. But, as someone who is lucky to not have 'been there', it's hard to know when I'm crossing a line and what's really needed. In fact, I think most of my efforts translate to "I know you mean well, but..." even though I'm also one of the few people these friends go to when things get bad. On top of worrying and trying to help, I also spend (probably too much) time thinking about what they're going through and what would be most helpful. It's exhausting for me and stressful, but it's personally not an option not to care. I end up internalizing this stuff and it affects my normal activities, even though at the end of the day, I'm not the one suffering. I want to be as good a friend and resource as possible to these people I truly care about and also want to avoid falling victim to anxiety or depression myself because of it. Any tips from either the 'been there' - depressed and knows what's helpful - perspective or the sincerly-caring-friend side of this equation would be much appreciated. Thanks.
Yeah, you're ill, but you're still being a nightmare...
I posted this question back in May, about my father's strange (and awful) behaviour that seems to be driven by some kind of illness. Things have not improved. Part of me says, "you should be there for him, it's your dad and he's obviously ill"; another part says "he's behaving like a monster, cut him out of your life." How do I determine which part to listen to? [more inside]
Recommendations for shoulder surgeon in NYC?
My son dislocated his shoulder and may require surgery. I am looking for an excellent surgeon in Manhattan. [more inside]
Convince me that kale can actually be tasty
We get a lot of kale from our CSA, and we pretty much know it's headed for the compost. Have tried many recipes that turn out nasty -- kale chips that won't dry, sauteed kale that's too bitter to choke down, etc. -- and have yet to find anything that gets us excited to use this vegetable, no matter how healthy. (Yes, I do make some green shakes, but one bunch in the freezer can fuel me for a year on that front! We have 3-4 bunches in the fridge right now.) I should say that the one exception was a recipe called "Carolina kale," which involves some stewed tomatoes and cumin, but our experience after making it a few times is that we love it on day 1 but then never want to touch the leftovers, so then that feels like a waste too. So, metafites, convince me that kale is fit for human consumption! wow me with your best, genuinely delicious, kale recipes, before it's compost time again!
Need help finding a doctor to talk about PrEP.
I'm a 35-year-old, gay male (in Silicon Valley) who is looking to jump back into the dating pool after a long absence. A bit after reading this post on Truvada for pre-exposure prophylaxis (PrEP) I thought I might be a candidate for it. I talked to my primary care doctor and although he though it as worth looking into, he didn't have any experience with Truvada and referred me to an infectious disease specialist. Unfortunately my experience with the specialist wasn't great; I felt like he dismissed the idea of PrEP almost out of hand and without really discussing my concerns or possible HIV risk factors. ... [more inside]
College student son depressed and unmotivated.
My 19 yr old son has decided to drop out of college after this semester to find himself. The problem is he is without a plan and I believe very depressed. He has been to a therapist in the past and has an appt to see the therapist next week. In the meantime he has called us sometimes crying and saying he doesn't understand why he is in college. snowflake inside [more inside]
Which health insurance plan makes the most sense for me?
For the first time, I have a choice of health insurance plans at a new job. I sort of understand the differences and benefits of each, but am feeling some serious choice paralysis. [more inside]
Constantly tired: like depression without the hopelessness. What gives?
I'm constantly tired to the point of not being able to get out of bed until early afternoon, napping frequently and generally feeling lethargic, apathetic and kind of nauseous. I finished a contract job 5 weeks ago & assumed my tiredness was a result of wrapping up the project. Then I went on a very chilled 3 week holiday and put the exhaustion on return down to jet lag. I've seen my doctor and my bloodwork is fine. My diet is decent, minimal alcohol, one coffee a day, so I'm fairly sure this is a psychological thing. I take an SSRI for anxiety but was actually talking to my doctor about tapering off as I've been really well for the past year. Physically, it feels like the bout of depression I had four years ago, but my mood isn't low (more flat) and I don't feel hopeless, just like everything's a massive effort, even helpful things like exercise and socialising. Obviously, YANMD, but has anyone else been there? What can I do to shake this?
How does a 20 yr old healthyish student get back in shape without dying?
The fact I never liked the "traditional" forms of exercise never bothered me before. That is, until it recently dawned on me activities like going to the gym or running might be the only options I have left. But, with sensitive knees and shins from growing quickly and the residual effects of childhood asthma still occasionally inhibiting my ability to do cardio, these activities seem more foreign than ever. What can I do? [more inside]
What could I do if I leave pre-med?
What other options are there besides pre-med? [more inside]
Alternative to coffee?
I am quitting coffee; too intense on my stomach. Is it the caffeine? Does caffeine in tea operate differently? Looking for some good alternatives, besides the usual Green Tea. But getting a health benefit is always good.
How does testosterone increase energy?
Testosterone helps my fatigue, but I have difficulty with the side effects. Explain to me the mechanism by which testosterone increases energy levels so that I can think sensibly about options and understand what this tells me about the cause of my problem. [more inside]
Health insurance while changing jobs?
Would I be penalized for not having health insurance in the US for three months while changing jobs? [more inside]
What kind of doctor for the whole body?
For the past few years I have been giving myself tendon injuries in quite a few of my joints... elbow's, knee's, and achilles mostly. I'm been slowly becoming more active for several years now, following an achilles injury that didn't quite heal up for 4 or 5 years. In my late 30's... I know, I'm shedding quite a bit of my invincibility at a steady rate now. As I said, I keep hurting myself. Mostly when I ramp-up the rigor, or try something slightly different at the gym. I have a pretty long and gentle warm-up and stretching routine, I don't think I really go for an increase too quickly, and only work out every other day or so... but various tendons disagree, at different times, and for different reasons. Based on the frequency and degree of pain/discomfort/etc, and how careful I am about not doing too much too quickly, I think frequency of injuries are out of the norm. Here's the nut of what I really want to know: What's the best kind of doctor (already tried my GP) to see about this? It's hampering some of my hobbies and reasonable ambitions quite a lot, so I want to start finding more aggressive help/tests/advise. Who can help from a whole body perspective? Yes to yoga, and learning all kinds of stretches. Looking for more than a PT at this point. Thanks all!
Some questions about adderall.
I recently started on adderall for ADD-type issues, and I've got some questions about the effects it's having. I intend to bring them up with my psychiatrist when I see him next, but that won't be for a few weeks and I think it would still be valuable to get some outside perspective, especially from people with first-hand experience. A lot of this has to do with sexuality. Questions and details within. A bit long-winded. [more inside]
The fan above my stove broke. Is inhaling cooking smoke dangerous?
The fan above my stove broke. I cook on the stovetop often, I've heard that the smoke from cooking could cause health problems down the road - but it's all anecdotal evidence. I've tried looking up some concrete information online, but what I can find is sparse. I'm opening the windows at the moment, but it's going to be too cold to do that soon. Is a fan necessary, or is cooking smoke not as bad as it's cracked up to be? Anyone else not using fans?
How do I get this infection to go away and stay away?
I have had a recurring bacterial vaginosis and yeast infection for over a year. I treat it, it goes away, and a few months later, it's back. To make matters more complicated, I don't have the typical symptoms. What originally lead me to think something was up is that I have to pee constantly, so I thought I had a UTI (which I have never had before). Turns out, I had a vaginal infection, and no UTI. It's been a year of this and I'm getting really frustrated. I'm seeing my ob/gyn next week about this, so I am not looking to metafilter as a substitute for medical advice. I want to know if there's anything I should be discussing with my doctor that I haven't already, or if I should be pushing for a referral to a specialist. More details and TMI below. [more inside]
Worth correcting ER documentation?
My friend took their child to the ER for a psych evaluation. There are mistakes in the report from the hospital. Should they bother to address them? [more inside]
Getting More MPG (Miles Per Glucose)
Is there a way to make my brain more "fuel" efficient? [more inside]
Your slogan here.
I run a program that directs people with HIV and at risk for HIV infection to research they might qualify for. We are co-sponsoring an event for providers in the HIV field. We would like to hand out swag mugs, but we have no idea what to say in such a small space. [more inside]
How much meat does a non-meat eater need?
I don't enjoy eating meat, but I am worried about getting enough b12. I eat b12 enriched nutritional yeast a few times a week, but I don't know if that's really enough. [more inside]
Lingering ankle pain weeks after overuse injury. What do I do?
Lingering ankle/foot pain after suspected overuse injury. What should I do? [more inside]

subset: commoncrawl


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IOWA CITY — When a decision to punt on fourth-and-one turned into fourth-and-forever Saturday for the Iowa football team, Kirk Ferentz understood the potential consequences.
After officials stopped the clock to review the spot of the ball after Keenan Davis gained seven yards on a third-and-eight play late in the Hawkeyes' game at Indiana, the Iowa coach scrapped his initial intention of having quarterback James Vandenberg attempt to gain the needed yard on a quick-snap sneak.
Instead, the Hawkeyes punted the ball away with 4 minutes, 43 seconds remaining, and the Hoosiers not only held on to the ball for nearly 41/2 minutes, they held on for a 24-21 victory.
"Like every decision you make, you do what you think is best for your team at that given moment based on the clock, timeouts left, all those types of things," Ferentz said Tuesday. "You could argue I made an irrational decision at Michigan State because we had gotten stuffed on some short-yardage stuff there."
Instead, Mark Weisman gained 5 yards on a fourth-and-one play from the MSU 20-yard line late in the third quarter. That decision helped set up a field goal that positioned Iowa to later tie a game it won in double overtime.
"We went for it, converted, and ended up scoring," Ferentz said. "Every situation is different. It's week to week. How is the team playing? How are they executing? Who is in the lineup? Those types of things are what you think about. At the end of the day, you're probably going to be right half the time."
Only three Big Ten teams have attempted more than the 13 fourth-down plays Iowa has run this season — Penn State, Purdue and Indiana. The Hawkeyes, however, share 10th in the league with Illinois with a 5-of-13 conversion rate on fourth down.
Iowa players say they understand the rationale behind the decision Saturday.
Davis said the stoppage of the clock changed the dynamics of the situation.
"To line up right away and go quick, it makes sense, but once the clock was stopped, that does change things, more than people think," Davis said. "There was still plenty of time for the defense to make a stop and give us time to get a score. It just didn't work out."
Offensive tackle Matt Tobin said by nature, linemen don't mind the challenge of trying to pick up a needed yard.
"That's kind of in our DNA. Fourth-and-three, no problem, you know," Tobin said. "Fourth-and-one, we'd go for it all the time because that gives us a chance to stay on the field."
Tobin and the Hawkeyes didn't get that chance, and Indiana denied Iowa virtually any opportunity in the final seconds.
Ferentz said once officials halted play to check the spot, the decision to punt was immediate and the choice to give the ball away was his.
"At that point, I had made up my mind," he said. "Just like I had told (offensive coordinator Greg Davis), let's go for it on the quick snap and it got stopped, it's my call. Don't be mad at Greg on that one. If anyone is mad at Greg, be mad at me."
Tobin said he respects the decision Ferentz ultimately made.
"We were geeked up, ready to go, ready to take off, and they called us back, it was a tough situation," Tobin said. "Coach said even if we got the play off they probably would have brought it back to check the spot. Coach made the call he felt was right in that situation. It's not an easy choice, but it was a call he felt was correct at the time he made it."
Iowa items
* The Hawkeyes expect to play without running back Mark Weisman and fullback Brad Rogers again this week. Neither made the trip to Indiana, Weisman because of what coach Kirk Ferentz labeled a strain and Rogers because of an undisclosed injury.
Ferentz said Weisman "is wearing the trainers out trying to get back, but he couldn't do anything Sunday, so I am not overly optimistic for this week."
* Ferentz said a lack of execution has been at the center of Iowa's offensive problems, not any issues with the scheme.
"It's execution more than anything else," he said. "We've been in the system long enough now that our guys know what they're supposed to be doing. We just haven't executed and it's been team thing. One thing affects another. We have to get more in sync."
* Micah Hyde will re-join James Vandenberg, James Ferentz and James Morris as co-captains this week, the first time the senior has been put in a position to be selected by his peers as a game captain since his arrest on Oct. 6 for public intoxication.
"That was one of the penalties he faced and that part has been paid, so he's eligible again," Ferentz said. "It's kind of a no-brainer. Micah is a tremendous young guy, a tremendous football player."
* Several hundred tickets remain for Saturday's game against Purdue.
Fourth-down flaws
Fourth-down conversion rates for Big Ten football teams:
Team Conv. Att. Pct.
Ohio State 7 9 77.8
Michigan State 6 9 66.7
Michigan 4 6 66.7
Nebraska 4 6 66.7
Indiana 8 14 57.1
Penn State 16 30 53.3
Purdue 10 20 50.0
Minnesota 6 13 46.2
Wisconsin 4 9 44.4
Illinois 5 13 38.5
Iowa 5 13 38.5
Northwestern 3 9 33.3


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Clairemont Coco's out, Chick-fil-A in
Some satisfied, some dismayed at approval of "another fast-food joint"
Julie Stalmer 6:30 p.m., July 23
Posted December 30, 2013
Walk, jog, or bike in this friendly community park that has a pond.
East Shepherd, or Greenbelt, trail is interesting in all seasons, with a combination of native coastal sage scrub and nonnative plants in the canyon. Walk north on Santo Road for about 160 feet, where the ...
Julie Stalmer 6:30 p.m., July 23
Various Authors 4:55 p.m., July 23
Mercy Baron 11:30 a.m., July 23
Charlie Morgenstern 11 a.m., July 23
Walter Mencken 10 a.m., July 23
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Various Authors 7:01 a.m., July 23
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text:
I looked closely at the photo. At first glance, it was just your typical drunk high school party group photo. However, on the far right of the picture was the head and shoulders of a man I had never seen before.
We've all been there. You've chosen the right filter, amped up the contrast, and captioned the hell out of an overhead photo of the most perfect latte foam heart you've ever seen.
Photographs are like time capsules that let you flit, for a second, between what was and what is.
Embarking a new relationship is similar to getting the keys to a new car.
Out of the thirty-two pictures in the album, we identified twenty of them. All of them infants, all of them dying within a few months of being born. We might have been able to identify more, I suspect, but some of the stones were so old that the inscriptions had been rubbed away and were unreadable.
As I went about that routine, I pondered the images. I started mentally searching my calendar for a good time to book a facial — a microdermabrasion facial, perhaps. Something to really erase whatever the hell happened to my skin.
People have always said controversial things, gotten out of control at parties, and done things they regret. What's changed is that today, no matter where you are, the world is always watching.
Sometimes, The Sims can be really scary.
Last week, we asked you to show off your school spirit by Tweeting or Instagramming your favorite "college" photos.
When a girl sends a man her naked picture, he gets excited (pun intended).


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For MIT students, it will be like taking Uber to class.
1Ford and MIT making LiDAR-equipped shuttle services that learn
- Joel Stocksdale
- 3 days ago
- 1
1Duckietown allows M.I.T. researchers to test self-driving cars | Autoblog Minute
- Autoblog Staff
- Apr 24, 2016
- 1
M.I.T's "Duckietown" allows researchers perfect the complex sciences behind autonomous driving. This video shows off their work. Eddie Sabatini reports on this edition of Autoblog Minute.
8How might autonomous cars shape our cities?
- John Beltz Snyder
- Mar 30, 2016
- 8
The way we change transport could change the way our cities look. It probably will, in fact.
11MIT plan may eliminate the need for traffic lights
- Jason Marker
- Mar 23, 2016
- 11
If the Massachusetts Institute of Technology has its way, the future of personal transportation might be smart intersections rather than self-driving cars.
17MIT students win Hyperloop pod design competition
AddToyota hires team of experts for billion-dollar AI lab
- Jonathon Ramsey
- Jan 5, 2016
- Add
The Toyota Research Institute announces the first hires for its technical team working on artificial intelligence and robotics.
5Toyota to invest $50M in AI research, will team with Stanford and MIT
- Brandon Turkus
- Sep 4, 2015
- 5
Toyota is dedicating itself to research into artificial intelligence, announcing a partnership with MIT and Stanford University.
3MIT puts V2V technology on its 2015 Top Ten list
- Jonathon Ramsey
- Mar 5, 2015
- 3
Ahead of autonomous vehicles, lightweighting, and hydrogen fuel cells, the MIT Technology Review puts vehicle-to-vehicle communications on its list of Ten Breakthrough Technologies of 2015. But with car hacking making more headlines more frequently, will V2V be just another way to for your car to be remotely commandeered?
6MIT figures out how to clean diesel trucks with RF signals [UPDATE]
- Danny King
- Jun 1, 2014
- 6
People rightfully dislike wireless signals being transmitted from the person behind the wheel when they text while drive, but there are times when a car's wireless signals can be good news. Researchers at the Massachusetts Institute of Technology (MIT) have found a way to use wireless signals under the hood to help cut pollution from heavy-duty vehicles such as diesel-powered trucks. That's something we can get behind.
1Audi, MIT, GE start cab ridesharing study in New York City
- Danny King
- Mar 18, 2014
- 1
Audi, Massachusetts Institute of Technology's (MIT) and General Electric are getting together to study something that won't likely be thrilling for New York City cab drivers. But there are bigger fish to fry and keeping cabbies happy.
15Ford partnering with MIT, Stanford on autonomous vehicle research
- Jonathon Ramsey
- Jan 24, 2014
- 15
Ask any car engineer what's the biggest variable in achieving fuel economy targets, and he'll tell you "the driver." If one human can't understand human driving behavior enough to be certain about an innocuous number like miles per gallon, how is an autonomous car supposed to figure out what hundreds of other drivers are going to do in the course of a day? Ford has enlisted the help of Stanford and the Massachusetts Institute of Technology to find out.
223MIT: vehicle emissions cause 53,000 extra deaths a year
- Danny King
- Aug 31, 2013
- 223
53,000 early deaths are attributed to exhaust from cars and trucks, annually.
42Berkeley study says drivers of roomier vehicles more likely to be unethical
- Brandon Turkus
- Aug 26, 2013
- 42
Researchers from MIT and Berkeley have conducted a rather interesting study on the correlation between posture and behavior. While this normally wouldn't be of much interest, the study analyzed more specifically how a car's seating position can affect the driver's behavior, which we find to be a rather interesting hypothesis.
3In Detail: CarKnow Car Hacking
- Adam Morath
- Aug 12, 2013
- 3
To hack, or not to hack? That is the thoroughly 21st-century question on the minds of many electronics consumers today.
196TRANSLOGIC 135: CarKnow Car Hacking
- Adam Morath
- Aug 5, 2013
- 196
#fivemin-widget-blogsmith-image-495338{display:none;} .cke_show_borders #fivemin-widget-blogsmith-image-495338, #postcontentcontainer #fivemin-widget-blogsmith-image-495338{width:612px;height:374px;display:block;}
4Hiriko, MIT's updated two-seat, all-electric foldable prototype, bound for carsharing
- Danny King
- Aug 7, 2012
- 4
Despite the name, it's not Japanese.
19Hiriko folding electric car headed for production
- Zach Bowman
- Jan 25, 2012
- 19
One very unusual electric car has debuted in Brussels. The Hiriko EV uses a hub-mounted electric motor at each wheel, though that's not the most interesting aspect of the vehicle. According to The Telegraph, the Hiriko uses an interesting rear suspension design that allows the vehicle to fold up, rotating the cabin vertically, to take up less space while parking. The partnership behind the vehicle say the car consumes approximately one third the parking space of a Smart ForTwo. Occupants enter f
86Hiriko folding electric car headed for production
- Zach Bowman
- Jan 25, 2012
- 86
One very unusual electric car has debuted in Brussels. The Hiriko EV uses a hub-mounted electric motor at each wheel, though that's not the most interesting aspect of the vehicle. According to The Telegraph, the Hiriko uses an interesting rear suspension design that allows the vehicle to fold up, rotating the cabin vertically, to take up less space while parking. The partnership behind the vehicle say the car consumes approximately one third the parking space of a Smart ForTwo. Occupants enter f
69MIT: U.S. could have much better MPG, but our cars got fat
- Mark Sumner
- Jan 5, 2012
- 69
Americans have gained weight over the last thirty years, and not just around the midsection. American garages and driveways have also put on pounds as cars have become larger and more powerful. A new study from MIT says that, if not for the increase in vehicle weight, we could already be exceeding vehicle mileage targets still years away.
28MIT: fundamental changes needed in energy policy
- Sebastian Blanco
- Dec 22, 2011
- 28
We "desperately need innovation in energy technologies." "Fundamental changes are needed in the U.S. energy-innovation system." "We face a very big innovation challenge over the next few decades, bigger than most people recognize."
56MIT working on algorithm to predict red light runners
- Chris Shunk
- Dec 5, 2011
- 56
Math geeks seem to think that complex algorithms can fix just about everything, and when it comes to red light runners, the geeks might be right. The Los Angeles Times reports that MIT researchers have developed an algorithm that can determine whether a driver will run a red light within milliseconds, which could one day save the lives of others.
- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
- Infiniti dealers ranked best, Tesla worst
- Compare Volvo XC90 and Lincoln MKX


text:
Aug 20, 2013
NICOSIA [MENL] -- The Arab minority has renewed attacks in Iran.
Jul 19, 2013
NICOSIA [MENL] -- Iran has again unveiled what it termed a vertical take-offand landing unmanned aerial vehicle.
Jul 12, 2013
WASHINGTON [MENL] -- Qatar has expanded its petrochemical infrastructure inan effort to diversify the energy sector.
May 22, 2013
ANKARA [MENL] -- Turkey has overseen a project to build an oil refinery.


text:
Crazy Substitute Teachers
Enjoy, NG4.02 / 5.00 2,476 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner4.01 / 5.00 2,765 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.97 / 5.00 6,691 Views
Great ending loved. treasure it always
the ending effin killed me LOL!!!!! great job as always.
Poor Patrick Sayze
This is great because it's just so funny with how ridiculous it is. I have no idea what's going on, but it's very entertaining. It's especially weird how these burgers and hot dogs actually have blood, or maybe that's supposed to be ketchup. I'm assuming the hot dog drowned, his bun would get soggy! No idea why he killed himself, but if he had, I would eat him too, even if I was a burger! The animation is nicely done too.
The best example of the quality is how you animate the rain continually going on. It even keeps it up for four minutes! The voices are nice and they seem to fit the characters and the scenarios they are in. If it wasn't a hamburger and hot dog, the fight scene might have been used in a serious movie. He shouldn't swim with shoes and socks on.
Fuckin crazy.
Wow you still got it
Still loving your toons man. Your the one that got me making these puppies.
Still I wonder...did the hotdog survive? May'be the world will never know...
I'd like to think that he survived :) Good luck to your future cartoons for 2011 and beyond!


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Hawthorn Hawks
Hawthorn's Bradley Hill may return to Perth
Hawthorn's triple premiership midfielder Bradley Hill may head home to Perth at the end of the AFL season.
10 things you did not know about Sam Mitchell
Sam Mitchell – aka Mitch, The Extractor, Diesel 2.0 – has received, and will receive many more, plaudits for reaching 300 games today.
Swans made right call on Talia
It is difficult to fault Sydney's handling of the Michael Talia arrest last weekend.
Hawks are singing, led by guitar-toting Clarko
Four-time premiership coach Alastair Clarkson likes to pull out a guitar and lead the Hawthorn players in group singalongs, Shaun Burgoyne says.
Six pointers: Your guide to round 18
The battle for eighth spot, the blockbuster at Simonds Stadium, Sam Mitchell's 300th game and Justin Leppitsch fighting for his job. Bit going on this round.
Mitchell: Hodge is Hutch to my Starsky
Sam Mitchell might not be a Hollywood movie star but if he ever landed the role of "Starsky", the Hawthorn champion nominated Luke Hodge to play "Hutch" alongside him.
Harvey, Tuck, Bradley: keeping a record of the records
Here's a hornet's nest for the poking. Brent Harvey this week equals Michael Tuck's VFL/AFL games record, and next week breaks it, God willing. But will that mean he has played the most games?
Hardwick challenges stars to bring best against Hawks
Richmond coach Damien Hardwick has thrown down the gauntlet to superstar midfielders Dustin Martin and Trent Cotchin ahead of the Tigers' daunting clash with Hawthorn at the MCG on Sunday.
AFL needs gay players to come out together: Greene
Gay AFL players have been urged to come out in unison to lessen the weight that's commonly thought to have inhibited a lone elite trailblazer from pronouncing his sexuality publicly to date.
Pay less? No stress for Burgoyne
Hawthorn superstar Shaun Burgoyne has confirmed that all four Hawk veterans are likely to play on in 2017 and says he'd be willing to play for less money to stay.
Hawks plan to keep Big Four vets
Hawthorn is planning for all of their veterans to play on next year and has commenced contract negotiations to keep them.
Longmire disappointed by Talia drugs incident
Sydney Swans coach John Longmire has expressed his disappointment at the behaviour of Michael Talia, saying he should not have got himself into the situation which led to him being arrested by police.
300-gamer Mitchell 'one of the footy's geniuses': Leigh Matthews
Hawk's milestone-collecting midfield maestro belongs in the same company as Williams, Voss, Hird and Buckley, says the AFL great..
Deledio could play against Hawks
Talismanic Richmond forward Brett Deledio has avoided major damage after suffering a calf strain in the Tigers' 19-point win over Essendon.
Recovery Session: Hawks remain side to beat
Football works on hyperbole. If it didn't, radio commentators would be out of work, TVs would turn to black and newspapers ... well let's not go into that, we have issues enough.
Sydney's Talia in drug bust
Sydney defender Michael Talia was with Hawthorn's Jono O'Rourke when he was arrested by police in possession of cocaine outside a Sydney nightclub on the early hours of Sunday morning.
What is the best way for Swans to use Franklin?
The Swans are undoubtedly a better side with Franklin in it, but how do they make the most of having the best forward in the game in their team?
AFL fines Port $20,000 over Hartlett head knock
League comes down hard for failure to follow the rules when assessing Hamish Hartlett after he received a head knock against Hawthorn.
Jack penalty a mistake: AFL lawmaker
A member of the AFL's laws of the game committee has conceded umpires made a mistake in handing a costly 50-metre penalty against Sydney captain Kieren Jack on Thursday night.


text:
Diabetes Health Center
Glycemic Index Directory
The glycemic index is a way of measuring effects of sugar in foods on your blood sugar. High-glycemic foods raise your blood sugar higher than low-glycemic foods. Some high-glycemic foods include white breads or pasta, rice, and baked goods. Some low-glycemic foods are vegetables, fruits, and whole grains. Follow the links below to find WebMD's comprehensive coverage about how the glycemic index works, how to follow a low-glycemic diet, and much more.
Medical Reference
Slideshows & Images
News Archive
Today on WebMD
Symptoms, diagnosis, treatment, and more.
10 strength training exercises.
12 practical tips.
Stars living with type 1 or type 2.
WebMD Special Sections
- Managing Diabetes, Insulin, and High Blood Sugar
- Your Child and Type 1 Diabetes
- Next-Level Fitness When You Have Diabetes
- Type 2 Diabetes: Learn How New Treatments Can Help You
- Live Better Daily With Diabetes
- 8 Snacks That Won't Spike Your Blood Sugar
- Living with Diabetes Assessment
- Diabetes: Keys to Better Daily Control
- Diabetes as You Age: Stay Active, Live Better
- Diabetes: Ready to Lower Your Blood Sugar?


text:
|October 16, 2014
Bob Woodward and Carl Bernstein
Pulitzer Prize-Winning Journalists, Authors and Political Analysts
Looking at the Presidency:
In the 1970s they set the standard for modern investigative reporting with a series of articles for The Washington Post that unraveled the Watergate scandal and led to the resignation of President Richard Nixon. Four decades later, the Pulitzer Prize-winning journalists and co-authors of All the President's Men and The Final Days are still leading the charge for informative, unbiased journalism.
Woodward, associate editor for The Washington Post, and Bernstein, Visiting Presidential Professor at Stony Brook University, are both
frequent contributors on MSNBC, CNN and all other major networks.
Free Film Screening of All the President's Men
Tuesday, October 14, 7:00 pm, Wang Center Theater


text: Tuesday, October 9, 2012 zara home!!! Can you tell I'm excited? As if fashion-forward apparel and hot-ass shoes wasn't enough, Zara went ahead and launch a home line that's melting my heart. Zara Home…so good! Photos via Zara Home Also on Style Me Grasiemaster bedroomholiday insta-giveaway week : day 2 parachuteliving roomdining room « pattern, shorts & a wedding?!style me bridal – the ring »SHARE TO: Taliah Soo funny! yes im excited too…i was on the site the other day and saw that tab but for some reason, didnt get to browse through. Looks AMAZING just like theyre uber fab clothes!


text:
Learn how to protect yourself from Internet scams. Read our online fraud prevention tips
Building Materials and Supplies ClassifiedsFor Sale Local NJ Classified Ads
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Can't find what you're looking for? Try our
Advanced Search
Capitol Fireproof Door Co. Mercury Lock & Door Service Inc. 529... more information
Web Id: NJC11188845
Published on NJ.com 11/3. Updated 7/15.
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Find A Local Business


text:
This page requires a MaxPreps membership account.
Don't stress... It's free and easy to setup.
The Palm Desert Aztecs baseball team won Tuesday's away conference game against Cathedral City by a score of 3-0.
(April 26, 2011: Cathedral City, CA 92234) Spectators at Tuesday's league battle between the Palm Desert Aztecs (Palm Desert, CA) and the host Cathedral City Lions (Cathedral City, CA), saw Palm Desert's baseball squad knock off Cathedral City by a count of 3-0.
Coming up next, the Aztecs play the Cathedral City Lions (Cathedral City, CA) in a Desert Valley battle, on Friday, April 29. Palm Desert will attempt to move on its 18-4 season record. The Lions enter the battle with a 11-14 record after their 3-0 league loss to Palm Desert (Palm Desert, CA).
The Lions now possess a 11-14 record. They take the field next when they travel to Palm Desert for a Desert Valley battle on Friday, April 29. Cathedral City will play a Aztecs squad coming off a 3-0 league win over Cathedral City (Cathedral City, CA). The Aztecs record now stands at 18-4.
Palm Desert's stats are presented by GameChanger: live mobile scorekeeping for baseballGameChanger Media, Inc (ai)


text:
Bypass the box office line at many theaters with guaranteed advance tickets. If something comes up, you can return or exchange them up until the posted showtime.
Earn rewards points from our partners, including AMC Stubs, Regal Crown Club and more.
Save your favorite theaters and movies to experience a customized Fandango just for you.
Get the VIP treatment, free screenings, digital downloads, discounts and more.
Looking for movie tickets? Enter your location to see which movie theaters are playing An American Werewolf in Paris near you.
This British-Dutch-Luxembourgian co-production is "based on characters created by John Landis" for his An American Werewolf in London (1981). In the opening, a man is seen under attack, almost managing an escape from the Parisian sewers before an unseen creature pulls him back. Meanwhile, tourist Andy (Tom Everett Scott) is seeing the sights of Paris with his pals Brad (Vince Vieluf) and Chris (Phil Buckman). When Serafine (Julie Delpy) leaps off the Eiffel Tower just before Andy is about to do a bungee-jump, he executes a mid-air rescue. She vanishes into the night, leaving Andy intrigued -- and also unaware that she is the offspring of the couple (Jenny Agutter, David Naughton) seen 16 years earlier in An American Werewolf in London. Andy tracks her down, asks for a date, attends a party, and winds up in her bed. When he awakens, he has toothmarks on his leg and is informed that he's making a transformation into a werewolf, confirmed by his sudden taste for rare steaks. Serafine explains that her stepfather (seen in the film's opening scene) had been working on a drug to control her werewolf transformations. Beneath a full moon, the lycanthropic love story continues. Filmed in Luxembourg, Amsterdam, Paris, and New York, with special effects mainly from California's Santa Barbara Studios. Werewolves were created by combining prosthetic devices and animatronics with computer-generated creatures. ~ Bhob Stewart, Rovi


text:
It useful to analyze the amount of words per article, top words, and so on. Very important for fluent writing and seo.
Again, I miss an update.
Thanks for the great plugin
Does what it says in the box, analyzes content for keywords, lets you track the amount of text you publish each month. Esthetically nice and usable. Good work!
You must log in to submit a review. You can also log in or register using the form near the top of this page.


text: Sorry if this has been discussed 1 million times, but I couldn't find much with the search feature. Can you all recommend a good quality gun belt that won't completely break the bank? Something that will last and has a wide range of adjustment? Thanks! Wanna kill these ads? We can help!


text: my son's family recently moved to Downers Grove, and I am visiting next week. I thought to spare my Daughter-in-law some stress by getting a taxi to and from the airport. There are several options to be found via Google but I thought I'd see if anyone has any specific recommendations or companies to avoid. I've not had much experience at this. Don't know whether to just grab one or get a reservation. For sure I would need a reservation for the return trip. Mainly I want to be safe and not wind up paying double the standard rate. I will have luggage; otherwise I might try public transportation.


text:
In This Section
Journal Forum
A Meta-Analysis of High Resolution Audio Perceptual Evaluation - June 2016
2 comments
Synthetic Reverberator - January 1960
3 comments
Sound Board: High-Resolution Audio - October 2015
4 comments
AES E-Library
Novel Sinusoidal Amplitude Coding Method for Paramtric Audio Codec
In this paper, new method for sinusoidal amplitude coding is presented. In MPEG-4 SSC (SinuSoidal Coding, Parametric coding for high quality audio), audio signal is decomposed into transients, sinusoids and noise component. Sinusoid component is decomposed further into frequency, amplitude and the phase. Each sinusoid of certain frame is linked to that of previous frame exploiting similarity of frequency, amplitude and phase to improve coding efficiency. Continuations are parts of a track with predecessor and successor. Births are parts of a track with successor alone. Continuations and births are quantized for bit-stream format and coded by Huffman entropy coding method. Applying this method to sinusoidal amplitude for births, bit-rate is reduced by 15.89% compared with MPEG-4 SSC.
Click to purchase paper as a non-member or login as an AES member. If your company or school subscribes to the E-Library then switch to the institutional version. If you are not an AES member and would like to subscribe to the E-Library then Join the AES!
This paper costs $33 for non-members and is temporarily free for AES members.
Learn more about the AES E-Library
Start a discussion about this paper!


text:
Wasting away: Skeletal Matthew McConaughey continues to suffer for his art on the set of The Dallas Buyers Club
A skeletal Matthew McConaughey reported for his first day on the New Orleans set of The Dallas Buyers Club Sunday.
The normally buff 42-year-old was spotted walking by his trailer in 1986 period garb - grey T-shirt, which hung loose, blue jeans, and glasses.
The incredibly shrinking star - sporting a Burt Reynolds moustache - also had a visibly large lesion on his forehead, an ominous sign of the AIDS affliction which took the life of his real-life character Ron Woodroof.
Getting in character: A skeletal Matthew McConaughey reported for his first day on the New Orleans set of The Dallas Buyers Club Sunday
You've changed Daddy: Matthew's pregnant wife Camila Alves brought their two children Levi and Vida to the set to pay him a visit
The Dazed & Confused actor, who
dropped 30 pounds, shocked onlookers Friday as he shuffled through the
security line at LAX.
Matthew certainly looked almost unrecognisable from the snake-hipped muscleman who lit up screens this year in stripper movie Magic Mike.
Both Brad Pitt and Ryan Gosling originally wanted to play Woodruff, the heterosexual, homophobic electrician who perished in 1992 after illegally smuggling HIV drugs not approved in the States.
Becoming Ron Woodroof: The normally buff 42-year-old was spotted walking by his trailer in 1986 period garb - grey T-shirt, which hung loose, blue jeans, and glasses
The Dallas Buyers Club, due out next April, reportedly focuses on the six months following his diagnosis.
Jennifer Garner, who starred with
McConaughey in Ghosts of Girlfriend's Past, recently replaced two-time
Oscar winner Hilary Swank as Dr. Eve Saks in the drama.
And Jared Leto just joined the cast as Woodroof's friend Rayon, a flamboyant HIV-positive cross-dressing hospital patient.
Awards fodder: The charismatic actor has never been nominated for an Oscar, Golden Globe, or Emmy, unlike Christian Bale who also lost a dramatic amount of weight for film The Machinist
The fact that the Paper Boy hunk is
so committed to altering his appearance for the role, might have
something to do with the fact that the charismatic leading man has yet
to secure an Oscar, Golden Globe, or Emmy nomination.
'I'm playing a guy who was sick and would have loved to have been healthier but wasn't,' Matthew told Us Weekly.
'For me, it's more of a mental thing than a physical thing. I'll get down to the weight I need to get to. I'm on my way, and it's what I need to do for the job.'
The actor is currently doing cardio, drinking a lot of tea, and eating five ounces of high-protein, low-carbohydrate foods a day.
Support: Matthew's wife Camila brought their two children Levi and Vida to see their father on set
However, the triathelete has already planned out his post-Buyer's Club celebratory meal - 'cheeseburger.'
The most famous thespian to have vigorously exercised the pounds off for a juicy role was Christian Bale, who lost 63 pounds for The Machinist thanks to a diet of coffee, water, a can of tuna, and an apple a day.
Rapper 50 Cent did a two-month liquid diet to lose 50 pounds for Things Fall Apart, while Matt Damon suffered adrenal gland damage from losing 50 pounds for his heroin addict character in Courage Under Fire.
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from 2016-09-27 to 2016-09-28
Teatro Argentina - Teatro di RomaDi S. Eyal, G. Behar, musiche di O. Lichtik, con G. Biran, R. Hytting, M. Kakizaki, L. Lerus, D. Devaney, K. Lurie Perdes, compagnia L-E-V Dance Company, presentato da REF Romaeuropa Festival 2016.
from 2016-09-21 to 2016-09-24
Teatro Argentina - Teatro di RomaRegia di H. Shechter, compagnia Hofesh Shechter Company, presentato da REF Romaeuropa Festival 2016.
from 2016-11-01 to 2016-11-06
from 2016-12-20 to 2016-12-26
from 2016-07-15 to 2016-09-24
In the nineteenth century, the ballrooms of the most important Italian Palaces were the privileged meeting place of the Italian and foreign nobility, where important relationships were established. The guests could listen to music and even find love, the artists performed in their beautiful bel canto and, above all, everybody danced!
The dance instructors created quadrilles, choral waltz, contredanses, and mazurkas, managing to involve everyone in the dances. These dances, presented in their original version but also reworked, will be the focus of this evening show so engaging, exciting, and romantic.
In the seventeenth century Palazzo Santa Chiara in the heart of Rome, you will experience something unique, immersed in the visual and sound suggestions of the nineteenth century. An invitation to dance and listen to the arias that will be sung and accompanied by renowned professionals of dance and bel canto, in the charming settings of the auditorium and the foyer. A tribute to Italy and Europe, an invitation to experience elegance and history.
from 2017-03-14 to 2017-03-26
from 2016-09-21 to 2016-09-22
from 2016-10-06 to 2016-10-16
from 2017-03-16 to 2017-03-19
Teatro Parioli Peppino De FilippoDi W. Shakespeare, regia di F. Veratti, musiche di P.I. Âżajkovskij, scene di M. Pesta, compagnia Balletto di Milano.
Museo Nazionale di Palazzo Venezia , Palazzo Venezia
Museo Nazionale di Palazzo Venezia , Palazzo Venezia
from 2016-09-27 to 2016-11-05
Albergo Roma | Home
Hotel Reviews


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Italy has a special place in the hearts of many Harlemites from Little Italy East Harlem to the food that is the cornerstone in so many of our neighborhoods. Continue Reading →
Category Archives: Italian Harlem
Ignazio Lupo, Head Of The Leading Mafia Family From Harlem
Ignazio Lupo (March 19, 1877 – January 13, 1947), also known as Ignazio Saietta and Lupo the Wolf, was a Sicilian-American Black Hand leader in Italian Harlem, New York City during the early 1900s. Continue Reading →
A Gangster Guns Down A Little Boy In Harlem, 1931
On the evening of July 28, 1931, five-year-old Michael Vengalli was playing with a group of friends on East 107th Street in Harlem's Little Italy. Continue Reading →
Italian Harlem, 1st Avenue And 114th Street, 1910
A slightly hand-colored photographs documents a very, very, very busy 1st Avenue and 114th Street, in the Italian part on East Harlem, New York, 1910.
Giosue "The King Of (Harlem's) Little Italy" Gallucci, 1865 – 1915
Giosue Gallucci (December 10, 1865 in Naples – May 21, 1915 in New York City), also known as Luccariello, was an old-style crime boss of Italian Harlem in New York City affiliated with the Camorra. Continue Reading →
East Harlem
East Harlem, also known as Spanish Harlem and El Barrio, is the eastern section of Harlem located in the northeastern extremity of the borough of Manhattan in New York City. Continue Reading →


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Anthera Pharmaceuticals Inc. (ANTH) is a company with a market cap below $100M and plenty of cash. It is ready to go into phase 3 trials with a B-cell molecule product [A-623]. Yet the company appears to be misunderstood by the market.
Anthera's B-cell molecule product, targeting lupus, appears to be an improvement over GlaxoSmithKline's (GSK) Benlysta [belimumab]. Anthera's phase 2 dose-ranging data was complicated and lacked statistical significance. However, the company found that the drug candidate is very active in sicker patients. Anthera has designed the clinical trials and obtained sign-off from both the FDA and the European regulatory authorities to start phase 3 late this year or early next year. We should get some additional data at the American College of Rheumatology [ACR] meeting in November.
The phase 3 trials, the ACR meeting and a good management team provide excellent catalysts in the coming months.
Sentiment: Strong Buy


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Source: Dream Spa at Gomersal Park Hotel
You can get a spa day including two treatments of your choice at the "fantastic, newly built leisure spa" (The AA) at the Gomersal Park Hotel for £59 -- that's up to 59% less than the regular cost.
10am-5pm Mon-Fri 22 Jul-22 Oct; +£20 Sat-Sun
Source: Village Spa Leeds North
You can get a spa day at Village Spa Leeds North, including 50 minutes' treatment time, for £39.
9am-8pm Mon-Fri until 30 Sep; +£15 9am-6pm Sat-Sun
Please go to your email and confirm your subscription.


text: My 83 yo mother and I met a friend of ours for lunch yesterday in Winkler. I thought it a bit strange to go to a restaurant claiming to serve Mexican food in a mennonite town but I was pleasantly surprised as the quality of food and the service was excellent! I had a combo plate that consisted of a... More


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Research 2009 - JC Pontoon Boats - NepTune 19 TT
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2009 - JC Pontoon Boats - NepTune 19 TT
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JC Pontoon Boats
NepTune 19 TT
19 ft. 0 in.
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JC knows that sometimes a small lake, small dock, small towing vehicle or small family calls for a smaller pontoon boat. But with a full 19' of deck and a generous 8 & ½' of beam; you will never think of this boat as 'small'! The NepToon 19 in either two-tube or TriToon (TT) version is the biggest 'small' boat you'll ever love!
Like all of our NepToon boats (except Ensign), it is available in either two-tube or TriToon (TT) versions.
The Neptoon 19 is available with the new Torqeedo electric cruise engine as well as traditional outboard power
8 ft. 6 in.
Fuel tank capacity:
Standard features:
·White powder-coated rails
·Aluminum side panels with vinyl heat-laminated to both sides
·Deck of ¾" 7-ply pressure-treated plywood with lifetime warranty
·Biminitop and boot made of acrylic fabric
·Roto-molded seat bases with vents and rain channels
·Stern gate and SS stern fold-up ladder
·L-group stern lounge with storage under seats
·Bow lounges with storage under seats
·30 oz. marine carpet
·Fiberglass helm with "flip-up" top
·Captain's chair with arms, slider, swivel & flip-up bolster
·Tachometer, volt, speedometer, fuel gauge, horn & 12V outlet
·Navigation lights and halogen docking lights
·25 gallon built-in fuel tank (twin tube models)
·55 gallon fuel tank in center tube (triple tube TT models)
·Helm & captains chair covers
·Aluminum bottom skin (standard on TT models only)
·Bass seats standard on fishing models
·Removable cocktail table with sea-rail
·Clarion CD/AM/FM with 4 speakers
·Tilt steering wheel
·Stainless steel cleats
·Lifting fins (strakes)
·Power assisted hydraulic steering
Optional features:
·Changing room with Sundeck available on most models (no charge option)
·Eliminate starboard gate to gain longer bow lounge (available on most models)
·Aluminum bottom skin (standard on TT models, recommended on twin tube models with 70 hp or more)
·Lounger arms with choice of removable cooler, flip-up table, trash container, sink, or storage
·Large upright cooler at end of lounge
·Removable bow gate seat
·Upholstery trim package
·Double-wide captains chair
·Adjustable height base for captain's chair
·Adjustable height base for cocktail table
·SS cup holders
·SS bow rails
·SS fender holder with 2 fenders
·Movable cup holders
·Deluxe instrument panel (adds trim, hour meter & water pressure)
·Digital depth gauge or Fish locator
·Compass, clock, hour meter
·Free-standing table with cooler inside
·Sirius satellite radio system
·Upgraded speakers by Clarion
·IPOD adaptor
·Porti Potti for changing room
·Hydraulic Steering (recommended on TT models)
·Ski Tow
·Mooring covers (available in Odyssey, Sunbrella or Aqualon)
·Sport Package (increases horepower rating)
·Torqeedo electric motor (19)
·Lifting fins (TT only)
·Wakeboard Tower
·IN-Tube ski storage
·12' power bimini
·Courtesy lights
·rear swim platform
·16.5' bimini
·SS bimini fittings
·Quick release bimini fittings
Not all options are available for the Ensign series. Check with your dealer for availability.
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Does anyone have any methods to remove what seems to be black rubber grease stains on new carpet. It has come from the black stoppers at the back of a portable piano.
Carolyn from Melbourne, Australia
Hi, try wiping the marks with orange oil or eucalyptus oil or tea tree oil, all will loosen tar and other marks,Try it on a piece of the carpet that can't be seen first to check for adverse effects. Use a clean white cloth for this. Hope this works for you.
How to remove rubber stains from my carpet.
I just registered with this site to thank all the people who helped me. I was removing an old shelf stereo system, and put it down on the carpet. When I picked it up there were two very black rubber marks. I found the answer (rubbing alcohol) at this site, and will be happy to participate here if I can in the future.
'Goof Off' works well. Test it on an inconspicuous place on your carpet first. Then use Cotton Balls and a clean rag to dab and wipe.
Add your voice! Click below to comment. ThriftyFun is powered by your wisdom!
I had rubber stains on a tablecloth from the rubber feet of a small appliance. I tried Stainstick, Shout, and laundry detergent to pre-treat it. Nothing worked. I read the advice to use rubbing alcohol on a cotton ball. I tried it and it immediately worked. I used about 3 cotton balls on each small stain, using a new one as the old one turned gray. Thanks to everyone for the much needed help. No elbow grease needed for this.
By Lynn
The WD40 method was excellent, worked like a charm. Try using on pen marks on wallpaper this also works (07/29/2007)
By Chris
WD 40 did the trick! I placed old electronic equipment on a white tabe. Took the black (little feet) marks right off! (10/21/2007)
By Al
|A friend of mine just purchased tan berber carpet about 6 months ago, he was vacuuming the carpet when the belt broke. Now he has rubber streaks on his brand new carpet. We've tried several things including oxy-clean, but the stain won't budge. Is there anyway to get the streaks off without hiring a professional?
Lynda in Cleveland
|Rubber Streaks on Carpet
|I would try club soda or rubbing alcohol. Or call Berber. If nothing else works, turn it into your insurance company.
|By AZLEADFOOT2
|Rubber Streaks on Carpet
|I have found that "Spot Shot" carpet cleaner is the best at getting out all kinds of stains. You can find it at grocery stores, Target, Sam's, etc.
|By AmyMasson
|Rubber Streaks on Carpet
|Because it is a new carpet (and Berber's I believe are made out of synthetic materials,) it might be best to hire or at least call a professional. A solvent that will take the stain out might also melt the carpet. Call around, some carpet cleaning services are better than others. Look for one that is bonded and certified. Call and ask questions about the rubber stain. It may cost a little to get the stain removed but replacing the carpeting is much more expensive. In any case if there are any scraps, test on the scrap or in a place that won't be seen.
|By Susan
|Rubber Streaks on Carpet
|Same thing happened to me but not on a berber carpet, but it was a closed loop large rug, I scrubbed it out with Simple Green.
|By dabirdie39
|Rubber Streaks on Carpet
|Same thing happened to us. Cotton balls and rubbing alcohol took it right out.
|By John & Vicki (Guest Post)
|Rubber Streaks on Carpet
|The alchohol worked like a charm!
Thanks for the idea.
|By Joyce. (Guest Post)


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Category:Revere Beach (MBTA station)
From Wikimedia Commons, the free media repository
This category has only the following subcategory.
- ► Crescent Beach (BRB&L station) (11 F)
Media in category "Revere Beach (MBTA station)"
The following 5 files are in this category, out of 5 total.
- Revere Beach MBTA.jpg 504 KB


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Book your room at Home-Towne Suites Kannapolis
Get an overview of this hotelHotel in Kannapolis with free parking
Located in the heart of Kannapolis, this hotel is within 6 mi (10 km) of Curb Motosports Museum, Old Courthouse Theatre, and North Carolina Music Hall of Fame. North Carolina Research Campus and Village Park are also within 6 mi (10 km).
Hotel Features
This hotel features WiFi in public areas, a business center, and meeting rooms. Self parking is free. Additionally, laundry facilities, barbecue grills, and a front-desk safe are onsite.
Room Amenities
All 80 rooms have flat-screen TVs with cable channels and feature kitchens with refrigerators, stovetops, and microwaves. Guests will also find sitting areas, WiFi, and DVD players.Would you like to give us feedback? Share it! Opens in a new window
Home-Towne Suites Kannapolis3200 Cloverleaf Pkwy Kannapolis NC 28083
Hotel Amenities
Hotel Amenities
Public areas are equipped with high-speed wireless Internet access (surcharge). Business-related amenities consist of a business center and meeting rooms. This Kannapolis hotel also offers barbecue grills, laundry facilities, and complimentary use of a nearby fitness facility. Complimentary self parking is available on site.
- Barbecue grill(s)
- Business center
- Elevator/lift
- Free self parking
- Front desk (limited hours)
- Laundry facilities
- Meeting rooms
- Number of buildings/towers - 1
- Number of floors - 4
- Safe-deposit box at front desk
- Total number of rooms - 80
- Free use of nearby fitness center
- WiFi (surcharge)
- Year Built 1999
Family Friendly Amenities
- DVD player
- Full-sized refrigerator/freezer
- Kitchen
- Laundry facilities
- Microwave
Available in all rooms: Wireless internet access ( USD .99 per night )
Available in some public areas: Wireless internet access ( USD .99 per night )
Free self parking
Room Amenities
- Air conditioning
- Cable TV service
- In-room climate control (air conditioning)
- Coffee/tea maker
- Free toiletries
- Cookware, dishware, and utensils
- DVD player
- Flat-panel TV
- Free local calls
- Full-sized refrigerator/freezer
- Hair dryer (on request)
- Iron/ironing board
- Kitchen
- Microwave
- Phone
- Private bathroom
- Separate sitting area
- Shower/tub combination
- Stovetop
- WiFi (surcharge)
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- In-room accessibility
Hotel Policies
Minimum check-in age is 21
Check-in time ends at 9 PM
Check-in time starts at 3 PM
Special check-in instructions:
Check-out time is 11 AM
Payment types
- Pets allowed for an extra charge
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
This property requires a deposit for any bookings where payment will be made in cash. Nightly guests paying cash require a USD25 total deposit daily. Weekly guests paying cash require a USD100 total deposit weekly. For more details, please contact the office using the information on the reservation confirmation received after booking.
Optional extras
- Fee for in-room wireless Internet: USD .99 per night (rates may vary)
- Fee for wireless Internet in public areas: USD .99 per night (rates may vary)
- A pet fee will be charged
Hotel Name
- Home-Towne Suites Hotel Kannapolis
- Home-Towne Suites Kannapolis
- Home-Towne Suites Kannapolis Hotel
We should mention
Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


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Reload the page and try again.
Off-Campus Dining:
There are so many options just walking distance from all the housing and its not just fast food they have great options from dinner to breakfast to dessert.
Off-Campus Dining:
There's a lot of variety, from mega-chain places like Burger King and Chickfille to family owned Vietnamese restaurants.
Off-Campus Dining:
There are a lot of different types of off-campus food options.
Off-Campus Dining:
Several fast food restaurants... Enough to eat differently each day of the week
Off-Campus Dining:
There are some places a short walk away, but walking at night in Azusa is scary and no one wants to do it alone.
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Pattern for the hat - "Berre meg"
CO 80 stitches on a sircular needle (50 cm).
Knit 8 rounds of *k1, p1* (or more, if you want to).
*k4, p1* throughout the round, and keep knitting the same for 18-20 cm (or more, if you want a baggy hat).
Decrease for top:
*k2, k2tog, p1* throughout the round.
Knit 4 rounds of *k3, p1*.
*k1, k2tog, p1* throughout the round.
Knit 3 rounds of * k2, p1*.
*k2tog* throughout the round.
Knit 2 rounds of *k1, p1*.
Knit k2tog throughout the round, pull the thread through all the stitches, and pull tight. Weave in both ends.


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NEW YORK -- San Francisco pitcher Dylan Brooks has been suspended for 50 games following an unspecified violation of baseball's minor league drug program.
Back in mid-November, the Giants agreed to terms on a minor league deal with
SAN FRANCISCO -- The Giants announced Tuesday that 21 players will be in camp as non-roster invitees, including several of the organization's top prospects.
Programming note: The "Coaching Corps Game Changer Awards" -- featuring Bay Area stars Stephen Vogt, Stephen Curry, Hunter Pence, Derek Carr, Torrey Smith an
NEW YORK -- Baseball's strike zone could be getting a slight lift.


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2005 Acura RSX Type-S 2dr Hatchback (2.0L 4cyl 6M)
This car is just a ton of fun. It's got pretty good torque off the line, but get the RPM's at about 6500 and feel 'er fly! The sport-tuned suspension (I have a Type-S) makes for great handling, yet the ride is still releatively quiet. The interior is very well designed, with the focus placed (as it should be) on the driver. While there is, technically, a rear seat for two, this is really only a two-seater for all intents and purposes. Small children and/or pets are the only things suited to being in the back. If you're looking for a passenger car, look elsewhere. If you want a fun car with nice pep and great extras (what a sound system!), get this car.
Engine (210hp from a 4-cyl!!), Handling, Sound system (Bose), Tons of standard equipment.
While the exterior looks sporty, I'd like to see a bit more of an aggressive design; the blind spot is massive in back, which makes for a difficult and nerve-wracking experience when backing out of the garage.
2005 Acura RSX 2dr Hatchback w/Leather (2.0L 4cyl 5A)
This car is amazing, especially on turns. The only area that I could criticize would be acceleration going up bridges, other than that...it's PERFECT! lots of room too.
Look, steering, size, reliability.
I love everything about this car. I was driving a 1987 Chrysler LeBaron because I never found anything new that would compare to its styling and handling until I found this.
Headlight Design
Power seat placement
This cars is my second honda purchase, my first being a civic dx in 99. I love veything about honda's reliability with my first car and now the RSX Type S has added great handling, incredible pick up, great high end speeds, and an appearance second to none. I would suggest this car to anyone who really enjoys driving a little too fast a little to often. As far as maintance i have had none which is right in line with honda's reputation. GO BUY IT TODAY!!
6 speed transmission, sport fitting leather seats, 17 inche rims and low profile tires from the factory.
Fuel efficiency which may be impossible when the car has so much output.
Im 51 and this is the 1st import I have ever owned. The car is amazing! The ride is smooth and the road feel is taught, but not "stiff". You can nail the gas pedal and hear it just come to life like a wild animal or take it out for a quite cruise at 70 while playing Motzart. The body style is unlike anything else on the road. And the quality and attention to detail is unsurpassed at this price. The Chevy Cobalt Supercharged version is in the same price range. But look closely... it doesnt hold a candle to the quality of the RSX Type-S.
The sunroof I love along with the "feel" of the leather. Dash vents spin a full 360. The sound of the motor and it power band is impressive too. Love the michilens and 17 inch wheels along with the phat stainless steel exaust tip. And believe it or not the glass is much clearer than US cars have.
The BOSE system is just ok and needs upgrading. Steering wheel radio controls would be nice. A power drivers seat would be great. Perhaps another 50 ponys under the hood would make this a Mustang killer !
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Free personalized radio that
plays the music you love
R-8 (Aube Remix)
Features of This Trackfour-on-the-floor beats
off beat style
light synth fx
an experimental musical style
a highly synthetic sonority
subtle use of noise effects
heavy use of white noise
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Ben Fordham – Greyhound Trainer Suspended
Rabbit carcass allegedly found on Harry Sarkis' property.
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Money News with Ross Greenwood
On air now 6:00pm to 8:00pm
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8:00pm to 12:00am
Rabbit carcass allegedly found on Harry Sarkis' property.
Andrew Joins Chris for his Weekly Chat
Kevin Rudd better not be counting on his support for the UN...
Alan talks to the Prime Minister for the first time since the election
Andrew Bolt joins Steve Price to discuss the latest in news...
Bet on sports & racing markets with an Australian owned bookmaker.
Are you a business owner? Do you want to reduce your current loan repayments up to 50%?
The Sydney International Boat Show, now in its 49th year, has been the hub of boating for many experienced recreational boaters; as well as those looking to learn more about the lifestyle.
The Sutherland Theatre Company proudly presents The Final Test, a hilarious play from acclaimed British novelist Chris Paling.
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With passion and integrity, TIGI Hair Reborn takes you on a journey of hair transformation and regrowth. Over time hair is restored, revived and awakened, metamorphosing into sublime, healthy looking shiny hair. TIGI Hair Reborn products introduce Hyper-Distillation™ Technology. For the first time available in hair care, this exclusive purification process has to date only been available in the highest grade pharmaceuticals. Hair is reborn once more.
Skin Dimensions Online is a dermatologist-owned skin care and beauty website where you'll find a wide variety of products to keep your complexion looking fresh and radiant. Whatever condition you experience, we have the products and insight to help you look and feel simply beautiful.
Fun in the sun can
come to a screeching halt when a skin care calamity appears …
While we will never stop recommending sunscreen, hats can
also be useful in …
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Elastic biodegradable starch/ethylene-co-vinyl alcohol fibre-mesh scaffolds for tissue engineering applications
The fabrication of a biomaterial scaffold, with adequate physical and structural properties for tissue engineering applications, is reported. A blend of starch with ethylene-vinyl alcohol (50/50 w/w, SEVA-C) is used to produce 3D fibre-mesh scaffolds by wet-spinning. The scaffolds are characterized in terms of morphology, porosity, interconnectivity, and pore size, using scanning electron microscopy (SEM) and microcomputed tomography (μCT). The degradation behavior, as well as the mechanical properties of the scaffolds, is investigated in presence of alpha-amylase enzyme at physiological concentration. Scaffolds with porosities ranging from 43 to 52%, interconnectivity of ∼70.5% and pore size between 118 and 159 μm, can be fabricated using the proposed methodology. The scaffolds exhibit an elastic behavior in the wet state with a compressive modulus of 7.96 ± 0.32 MPa. Degradation studies show that SEVA-C scaffolds are susceptible to enzymatic degradation by alpha-amylase, confirmed by the increase of weight loss (40% of weight loss after 12 weeks) and presence of degradation products (reducing sugars) in solution. The diameter of SEVA-C scaffolds decreases with degradation time, increasing the overall porosity, interconnectivity and pore size. In vitro cell studies with human osteosarcoma cell line (SaOs-2) showed a nontoxic and cytocompatible behavior of the developed fibre mesh scaffolds. The positive cellular response, together with structural and degradable properties, suggests that 3D SEVA-C fibre-meshes may be good candidates as tissue engineering scaffolds. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40504.
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Chemoenzymatic Synthesis of All Four Diastereomers of 2,6-Disubstituted Piperidines through Stereoselective Monoamination of 1,5-Diketones
The regioselectivity of various enantiocomplementary ω-transaminases was evaluated for the stereoselective monoamination of designated 1,5-diketones; excellent conversions, enantio- and regioselectivities were observed. The resulting amino-ketones underwent spontaneous intramolecular ring closure to afford Δ1-piperideines, which served as precursors for the cis- and anti-piperidine scaffold as demonstrated for the synthesis of the alkaloids dihydropinidine and epi-dihydropinidine. Key to the success of accessing the trans-piperidines was a Lewis acid mediated conformational change of the Δ1-piperideines in the reduction step. Thus, all four diastereomers of 2,6-disubstituted piperidines could successfully be prepared.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.