text:
TEMPORARY SOLUTIONS: Why Performers Are Tempted by Temping
Have you ever said you were a performer, only to hear the response "Oh, really...what restaurant do you work for?"
TEMPORARY SOLUTIONS: Why Performers Are Tempted by Temping
Have you ever said you were a performer, only to hear the response "Oh, really...what restaurant do you work for?"
LONDON CALLING - Edinburgh's Fringe Has Grown
The media has been saturated with coverage of the 51st Edinburgh Festival, which wound up on Aug. 31. Americans at the main Festival included the Twyla Tharp Company, the San Francisco Ballet, and Mark Morris, whose production of Rameau's comic opera Platƒe was highly acclaimed. As always the British ...
Vandenbroucke, Northlight Theatre A.D., to Step Down
Effective next June, Russell Vandenbroucke will step down as artistic director of Northlight Theatre after 11 years. He will complete the current season by directing Sophocles' "The Wound and the Bow," in a new adaptation by Amlin
Broadway's Hour-Long Commercial
The League of American Theatres and Producers has filmed a one-hour news retrospective that takes a behind-the-scenes look at the 1997-98 season on Broadway. It will air nationally in syndication from May 20 through June 7,
N.Y. NOTES : OUT OF TOWN - Boom and the Bard - Shorter shows, soaring Shakespeare, and collapsing scaffolds create lots of sound and fury, signifying new trends on the Main Stem.
The biggest story of the month here in New York is the recent scaffolding collapse which cut off Times Square from traffic and closed several shows. All of the shuttered attractions are up and running again with the exception of Cabaret. The Kit Kat Klub which houses the smash revival ...
By any number of collaborations over the years, co
By any number of collaborations over the years, connect the names of two performers or creators who have never worked together, and receive a Back Stage West T-shirt. Weekly winners are chosen by the creativity, cleverness, and brevity of their connections.
Update Your Shakespeare: Theatres Mount Timely Twists on Timeless Tales
Are theatres afraid audiences will be bored by bare Bard? Or do they think the most commercially minded playwright of the Elizabethan era would rejoice to see revisions of his revels? Shakespeare's themes are universal and-as contemporary directors feel-timeless. But do his texts hold up when his plays are
The full-length ballets seem to be enjoying a renaissance at American Ballet Theatre this season. Ben Stevenson's Cinderella, which had its world premiere by National Ballet of Washington in 1970, entered the ABT repertoire on May 17, and turned out to be, in show-biz lingo, "a real
The filling of a Screen Actors Guild board vacancy created by the death of Steve Allen has elicited allegations of "cronyism" from disgruntled board members. The board seat to which Allen was elected shortly before his death Oct. 30 was filled on Nov. 13 by Chuck Sloan.
By Roger


text:
DEFINITION of 'Shadow Rating'
1. The name given to a bond rating performed on an issuing party by a credited institution, but without any public announcement of the results.
2. A rating given by S&P to Israel Bonds, which are not permitted to be traded on the secondary market.
Next Up
BREAKING DOWN 'Shadow Rating'
1. Shadow ratings are useful for companies trying to assess how much a debt issue might be worth to investors. Rather than publicly releasing the results of a credit analysis by a third party, companies might wish to first know what the results are before it is released to the public.
2. These ratings were given to determine the credit worthiness of bonds with no secondary market. In the past, Israel Bonds were considered to be more representative of donations rather than safe investments.
Issue1. The process of offering securities as an attempt to raise ...
BondA debt investment in which an investor loans money to an entity ...
Bond RatingA grade given to bonds that indicates their credit quality. Private ...
High-Yield BondA high paying bond with a lower credit rating than investment-grade ...
Tel Aviv Stock Exchange (TLV) .TAThe securities market in Israel. Securities exchange in Israel ...
Moody's Bond SurveyA weekly publication that reports changes in corporate bond quality ...
Related Articles
Explaining Interest Rate RiskInterest rate risk is the risk that investments already held will lose market value if new investments with higher interest rates enter the market.
Why Bad Bonds Get Good RatingsCredit ratings are not the only tool to rely on when assessing bonds. Find out why they sometimes fall short.
Managing Wealth
5 Reasons to Invest in Municipal Bonds When the Fed Hikes RatesDiscover five reasons why investing in municipal bonds after the Fed hikes interest rates, and not before, can be a great way to boost investment income.
U.S. Corporate Bonds: The Last Safe Place to Make MoneyThere aren't many other sources right now for relatively safe, steady income.
Corporate Bond Basics: Learn to InvestUnderstand the basics of corporate bonds to increase your chances of positive returns.
Managing Wealth
Six Biggest Bond RisksDon't assume that you can't lose money in this market - you can. Find out how.
Personal Finance
How To Choose The Right Bond For YouBond investing is a stable and low-risk way to diversify a portfolio. However, knowing which types of bonds are right for you is not always easy.
ETFs & Mutual Funds
Key Strategies To Avoid Negative Bond ReturnsIt is difficult to make money in bonds in a rising rate environment, but there are ways to avoid losses.
Explaining Bond RatingsA bond rating is a grade given to a bond to indicate its creditworthiness.
Why Israel Is Attracting Chinese Investors (BIDU)Chinese investment in Israel has taken off since 2011. What opportunities do Chinese investors see in the country, and what does the trend mean for Israel?
Is buying bonds on the secondary market safe with what the market is doing?... Read Answer >>
Where can I find information about corporate bond issues?Learn information about corporate bond investments, including where investors can access information about new corporate ... Read Answer >>
Which factors most influence fixed income securities?Learn about the main factors that impact the price of fixed income securities, and understand the various types of risk associated ... Read Answer >>
What are the key factors that will cause a bond to trade as a premium bond?Learn about the primary factor that can cause bonds to trade at a premium, including how national interest rates affect bond ... Read Answer >>
Why are most bonds traded on the secondary market "over the counter"?Like stocks, after issuance in the primary market, bonds are traded between investors in the secondary market. However, unlike ... Read Answer >>
What causes a bond's price to rise?Learn about factors that influence the price of a bond, such as interest rate changes, credit rating, yield and overall market ... Read Answer >>

subset: commoncrawl


text:
UPDATE: Deutsche Bank Initiates HD Supply at Buy on Adjusted Forecast Estimates
In a report published Tuesday, Deutsche Bank analyst John G. Inch initiated coverage on HD Supply (NASDAQ: HDS) with a Buy rating and $28.00 price target.
In the report, Deutsche Bank noted, "We are launching coverage of HD Supply with a Buy rating and 12-month price target of $28. HD Supply completed its successful IPO in July 2013. Our adjusted forecast estimates (excluding intangibles amortization) are $1.75 in 2014 and $2.55 in 2015. Our rapid EPS growth forecast is driven by above-average market sales expansion, declining interest expense, significant structural tax benefits and step-down in intangibles amortization."
HD Supply closed on Monday at $23.00.
Latest Ratings for HDS
|Jun 2016
|Longbow Research
|Initiates Coverage on
|Mar 2016
|Sterne Agee CRT
|Initiates Coverage on
|Mar 2016
|Morgan Stanley
View More Analyst Ratings for HDS
View the Latest Analyst Ratings
Posted-In: Deutsche Bank John G. InchAnalyst Color Initiation Analyst Ratings
© 2016 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.


text: Share Tweet +1 Submit Share Link First Previous Next Latest If the Glove Don't Fit… [ COMIC ] Shepard just needs to go shopping with some Asari and she'll be fine. source: deviantART Share Tweet +1 Submit Share Link You May Also Like Video Games Most Flawless Fannies Gamer's Dad Important Work Comments Erick Awesome! I never noticed that! Scott I've often thought – when stubbing a little toe on something – that Protoss-style three fingers would be enough. Getting one or two of them dirty with food and continuing to type/carry stuff with the clean fingers convinced me of the utility of extra digits.


text:
September 29, 2012
A Random EncounterRate this encounter:
Adam -- Slough, United Kingdom -- Summer 1974
I have had many experiences over the years. I am posting this because I bought The Ghost Files and found out about Ghostvillage.com.
I have never been shy about talking about my encounters but I have never seen a relative or friend, nor have I or been in a historic building or landmark when my encounters occurred. It has always been random. I never have a warning when they are about to happen. It just...happens.
Most are quite ordinary I suppose, but two encounters in my 20's were physical and terrifying. One, in particularly, occured when I was aged 14. I delivered newspapers before school. This morning it was a bright blue sky and about 6.30 a.m. The girl that sorted the papers out had mixed them up. I realised this when I took the paper out the sack for the first house.
I sat on the curb to rearrange them. It was a cul-de-sac, not a soul in sight or a car in motion. I stood up everything in order, turned to go through the first gate and there she was -- the ghost -- right in front of me.
This was summer so I was in a tee shirt and jean jacket. This lady was dressed for a cold winter. She was at least 60 years old and stood about 5 ft 2". She had a head scarf and a heavy winter coat that went below her knees. She wore Derry boots (sheep skin lined ankle boots with a zip up the front). She also donned black framed glasses. She looked me straight in the face and had a big open smile, and looked solid as you or I.
"Morning! It is a lovely day isn't it" I said. She said nothing, just looked and smiled.
I continued, "You on an early shift?" No response. She just looked and smiled. I was feeling a bit uncomfortable and remember thinking idiot. I then said "I'm running late, I'd better crack on."
Right then she disappeared. Not a fade away type of vanishing but like a light being turned off. The only thing I felt at that point was ridged fear. I don't know why it happened or if it was a message. Maybe it was an imprint ghost.
This was my first obvious encounter. I tend to ignore shadows or voices and put them down to being tired or lucid dreaming. But when I'm awake and active and I have encounters I know they are real.
404 Error - page not found
Our latest posts
Where Are the Naked Ghosts?Why aren't ghosts naked? Not to worry... Ghostvillage.com isn't going "blue" this month. And we're not turning into that kind of Web site, either....
An Evil Presence During Our Parents' DivorceWitness: Danny Osborn Location: Oklahoma City, Oklahoma Date of Encounter: February 1978 My twin brother and I would go stay the weekends with our father when...
The Third Eye ConnectionOne question I frequently get asked is to explain something fascinating that I have experienced working as a forensic psychologist in the metaphysical community....
The Dark Presence at the Top of the StairsWitness: Raymond Garcia Location: Wheat Ridge, Colorado Date of Encounter: March 10, 2014 Several years ago as a child around the age of 7...
The Ominous Black FigureWitness: Christina Henderson Location: Bloomington, Indiana Date of Encounter: May 12, 2016 I lived with a roommate for a while and we have been...
Superstitions During the Month of JuneThe deep yearning to make a connection with lost traditions of superstitions and folklore always have me searching for the little details that have...


text:
Katrina & Beyond
'Vent Tent' Offered Many Support in a Storm
Waveland, Miss., has suffered profoundly from the wrath of Hurricane Katrina... but thankfully, not always in silence. For four weeks, amid the rubble of a Catholic church, a hand-scrawled sign invited entrance to the "Vent Tent." There, people who lost nearly everything to the storm and have struggled through a painful aftermath, were given a chance to tell their stories to trained counselors.
The David Oak
Dr. Thomas Peavy Retells a Story Heard in the 'Vent Tent'
After service to more than 300 visitors, the tent is closing this weekend. Local counseling programs and churches will step in.
Dr. Thomas Peavy, a professor of counseling and psychology, spent time as a "Vent Tent" volunteer. His hope? That despite "damage and death to hopes and dreams and futures," those who retain "the ability to look at this tragedy and move forward" will have found "new hope, new future and new direction in life."
Related NPR Stories
You must be signed in to leave a comment. Sign In / Register
Please keep your community civil. All comments must follow the NPR.org Community rules and terms of use, and will be moderated prior to posting. NPR reserves the right to use the comments we receive, in whole or in part, and to use the commenter's name and location, in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.


text:
Jessica Alba Heads South of the Border For a Family Friendly NYE!
Jessica Alba Heads South of the Border For NYE and Hypes Blue Valentine!
Jessica Alba celebrated her final hours of 2010 with friends and family in Cabo on Friday. She was up bright and early on Saturday to join Honor and Cash by the pool, though the actress kept her bikini body covered up under a floral sundress. Little Fockers maintained the top spot at the holiday box office and tomorrow sees the DVD release of her campy slasher film Machete. She spent a few weeks prior to the holidays promoting the third film in the Focker franchise, but Jess has also been talking up Blue Valentine and the flawless performances from stars Ryan Gosling and Michelle Williams.


text:
Dodgers' Kemp returns, homers in 1st at-bat
Updated: July 21, 2013, 2:57 PM ETAssociated Press
Use a Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook name, photo & other personal information you make public on Facebook will appear with your comment, and may be used on ESPN's media platforms. Learn more.


text:
Aaron Brown
I'm a Systems Engineer on the Technical Operations team at Amplify Education. I occasionally blog at The 9 Minute Snooze.
- New York, United States
- blog.9minutesnooze.com
- Member for 4 years, 9 months
- 1 profile view
- Last seen Mar 19 '13 at 1:44
Communities (6)
Top Network Posts
- 22Is it feasible to have home folder hosted with NFS?
- 21ssh via multiple hosts
- 19How to manage millions of users?
- 17What is `^M` and how do I get rid of it?
- 17Is RAID 1 overkill on Amazon EBS drives in terms of reliability?
- 16Password Management System for multiple SysAdmins?
- 15How to automatically start and shut down VirtualBox machines?
- View more network posts →
Keeping a low profile.
This user hasn't posted... yet.
Badges (5)
Gold —
Silver 4
Bronze 1


text:
Opening Ceremony
Stardust Sweater Dress
- Size
Product Actions
Merino wool and lurex blend sweater dress with metallic diamond knit pattern, and rib-knit neckline, cuffs, and hem. 34" length. Available in Navy/Copper. Imported. Merino wool/lurex. Dry clean.
Style # 503058114
Style # 503058114
Taking its name from the elaborate international festivities that occur at the start of the Olympic Games, Opening Ceremony celebrates style trends from countries around the world. Founded by Carol Lim and Humberto Leon in 2002, the brand brings together emerging talent from the U.S. and abroad to create delightfully unexpected and irresistibly energetic designs.
Need Help? Have Questions? Contact Us.
Please call 1.888.222.7639 to speak with a Customer Service Representative.
We're here to help you:
Monday - Friday, 9 AM - 9 PM (ET)
Saturday - Sunday, 10:30 AM - 7 PM (ET)
If you prefer email, we can be reached anytime at email@example.com.
Free Shipping & Returns on all U.S. Orders. See Details.


text:
20 Jul 2010
Our J.I. Halsell will be providing an analysis of each NFL team's salary cap situation for ESPN over the next two weeks. He starts in the NFC North, where the Vikings notably have less than $9,000 in dead money on their cap.
0 comments
Patrick Peterson's dominant coverage was a big reason the Cardinals won their first division title in six years.


text:
KING OF PRUSSIA, PA-Keystone Property Group has recently leased a total of nearly 19,000 square feet at its Parkview Tower office building.
The transactions include:
- Reval.com Inc. taking a 66-month lease for 7,076 square feet. The company provides software for treasury and risk management.
- Bankers Life Insurance signing a five-year lease extension for 8,179 square feet.
- Contemporary Staffing Solutions' signing for 1,844 square feet.
- PP Pediatric Management renewing for 1,900 square feet.
Keystone was represented in all of the transactions by Jeff Barker and Kim Finnerty of Cushman & Wakefield.
Located at 1150 First Avenue, the 220,513-square-foot nine-story building is connected to a Radisson Hotel and the Valley Forge Casino, offering tenants access to large conference facilities, a food court, spa and several full-service restaurants.
Parkview Tower also includes on-site amenities, including a deli, telecommunications with fiber optics, a back-up generator, ample parking and 24-hour security.
Keystone makes continuous upgrades to the common areas, bathrooms and lobbies.
Tenants include Arcadia University, Huntington Bank, SAIC, TekniPlex and Fort Dearborn Life Insurance.


text:
Plug it in?: The decision to integrate condition monitoring
Efforts to tighten communications of condition-monitoring instrumentation and data analysis software with CMMS and automation infrastructure, combined with the proliferation of wireless sensor systems and the drive to reduce manpower skill and time requirements, are bringing implementation costs down and drawing much attention to this approach. But should you implement it?07/28/2008
Ingredient Round Up August 2008: Dairy Flavors and Ingredients
August's Ingredient Round Up focuses on dairy foods and nondairy replacements07/31/2008
Equipment Round Up August 2008: Flow and Level Measurement
Food Processing showcases a variety of flowmeters & level measurement products07/31/2008
Don't Sacrifice Bone Health For Weight Loss
You don't have to sacrifice bone health for a slimmer physique08/07/2008
Pomegranate May Be Viable Alternative to Anti-Inflammatory Drugs
Pomegranates may be a viable alternative to anti-inflammatory drugs08/07/2008
Caffeine May Prevent MS
MS prevention may be just a cup of coffee away08/07/2008
Can Processed Tomato be Healthier than Fresh?
FruHis may increase processed tomatoes' cancer-fighting potential08/07/2008
How Effective are Blueberry Antioxidants?
Fight free radicals with blueberries08/07/2008
Broccoli Linked to Lower Incidences of Prostate Cancer
A new study links broccoli and prostate health08/07/2008
Survey Showcases Dietary Differences Between Genders
A new survey showcases the dietary habits of men and women08/07/2008
Potato Preparation Affects Taste and Nutritional Content
Potato preparation affects both taste and nutritional content08/07/2008
Resvida Promotes Heart, Brain, and Muscle Health
Resvida promotes heart, brain and muscle health08/07/2008
South American Uchuva Provides Sweet Taste, High Fiber
Savor the sweet, tangy taste of this fiber-rich, South American superfruit08/07/2008
Organic Rosemary Portfolio Expands
Ecocert-certified rosemary preservatives offer antioxidant and antimicrobial protection08/07/2008
High-Fiber Flour Alternative Doesn't Sacrifice Taste, Texture, or Appearance
Add dietary fiber to your baked goods without sacrificing taste, texture or appearance08/07/2008
BioAgave Agave Active Fiber Features Superior Stability
Fill the fiber gap in modern day diets with inulin08/07/2008
VegeFull Bean Ingredients Increase Protein and Fiber Without Altering Taste or Texture
Liven up your favorite dishes with the nutritional benefits of beans08/07/2008
Research Data for Top 100 Food and Beverage Companies 2005 - 2008
Food Processing presents research data for the top 100 Food and Beverage companies in 2005, 2006, 2007 and 200808/11/2008
How Worthwhile is Lube and Oil Analysis?
September's MRO Q&A answers your questions about lubrication and oil analysis in the food processing industry08/14/2008
Top 100 Food Companies: Profiles 1-2508/22/2008


text:
The words "challenge" and "challenger" are well-known, but is there such a term as "challengee" - as I read somewhere? In other words, what would be an appropriate term to describe the person challenged, for instance, to play a challenge match? Unsure whether to ask for the "antonym" of challenger.
English Language & Usage Stack Exchange is a question and answer site for linguists, etymologists, and serious English language enthusiasts. Join them; it only takes a minute:
Sign up
Sign up
Here's how it works:
- Anybody can ask a question
- Anybody can answer
- The best answers are voted up and rise to the top
However Opponent is in my opinion a better word for the other person in a contest
Challenger and Challenged (sometimes "the challenged")are perfectly acceptable.
I would go for the one challenged, which emphasises the binary relation with the challenger. It has some good results in Google books, among which :
(Paul in the Greco-Roman World: A Handbook edited by J. Paul Sampley)
The term generally used in boxing (which would be a good fit for what you want) is "defending champion."


text:
Special to Page 2
The TV Guide Channel. Everyone's cable package comes with it, or at least some sort of programming guide that provides a brief description of each show.
To me, the programming guide is an invaluable tool. It lets me know what is on when and what each show is about so I can determine whether I want to watch it.
For instance, the description for this Sunday night's "Desperate Housewives" episode read: "(Comedy-Drama) Bree is confronted with Orson's hidden past; Susan professes her love for Ian; and Carlos and Gaby try to make up."
Short and sweet. I've never seen the show, yet I know from three sentences that those housewives are indeed desperate.
Or take the synopsis of last evening's broadcast of "Laguna Beach" on MTV: "A reality series that follows rich and beautiful teenagers and their intertwining love lives."
That was just a one-sentence description. And from that one sentence, I know that because I am older than 14 and am the owner of a pair of testicles, "Laguna Beach" is not for me.
But it wasn't until this Sunday that I paid any attention to the TV Guide Channel when it came to sporting events. I assumed the outcomes of games were not determined until they were played on the field. Then I happened across these descriptions of NFL games while I was flipping through the channels Sunday morning. And I quickly discovered that my programming guide channel knows all.
San Francisco at Chicago
(Comedy) The 49ers get humiliated by a superior foe. Repeat.
Pittsburgh at Oakland
(Comedy) In an episode inspired by "switcheroo" films such as "Trading Places" and "Freaky Friday," the Super Bowl champion Steelers swap football abilities with the woeful Raiders in this madcap comedy romp. Ben Roethlisberger puts in one of the best performances of his young career by playing a bumbling, clueless quarterback, flawlessly channeling numerous Raiders signal callers from years past. Oakland fans get in on the hilarity by dressing up in ridiculous outfits.
Indianapolis at Denver
(Drama) The third installment in a recurring series in which Denver's defense is destroyed by Indianapolis. Jake Plummer appears, in what could be his final performance.
St. Louis at San Diego
(Action) A weekend visit to sun-soaked San Diego goes awry for the Rams. But they luckily escape without being killed by a manic, drug-fueled opponent played by Shawne Merriman.
Baltimore at New Orleans
(Drama) An egomaniacal, power-hungry leader (Brian Billick) and his band of miscreants inflict misery on the locals while Reggie Bush continues in his miscast role as an NFL superstar.
Atlanta at Cincinnati
(Drama) Michael Vick continues to show his range with another convincing portrayal of a passing quarterback. This episode includes a guest appearance by Cincinnati receiver Chris Henry, returning to the show between suspensions.
Arizona at Green Bay
(Drama) A young, dreamy outsider (Matt Leinart) visits a small Wisconsin town, but Brett Favre shows him it takes much more than sexy stubble to become great.
Jacksonville at Philadelphia
(Drama) Donovan McNabb reprises his role as the lovable loser. But his performance is met with a chorus of boos by those wanting him to branch out and try something new, or at least deliver one of his trademark vomit scenes. David Garrard guest stars in place of Byron Leftwich for Jacksonville and delivers a subtle, if unremarkable, performance.
New York Jets at Cleveland
(Comedy) In an episode inspired by the "Jackass" movies, groups of men with no future risk bodily harm.
Tampa Bay at New York Giants
(Drama) Brother goes against brother in an episode that evokes many epic Civil War films, with Shelby Foote as special guest commentator.
Seattle at Kansas City
(Drama) Larry Johnson gives the performance of a lifetime and Damon Huard delivers in yet another Kansas City win, leaving Trent Green to wonder whether he's still concussed or it's actually true that he could lose his job to whoever this Damon Huard guy is.
Houston at Tennessee
(Comedy) Pacman Jones stars in this hilarious, turnover-filled comedy that will have you cracking up and doing spit-takes as though Jones were right there in your living room.
Dallas at Carolina
(Drama) New cast member Tony Romo stars for Dallas. But Drew Bledsoe reprises his former leading role by standing stationary all night long. Only this time, it's on the sideline.
Eagles excited to head to bye week with plenty to work on
Chad Johnson vows he will torch next opponent for 60 or maybe even 70 yards
Ben Roethlisberger fearing trick-or-treaters will just punch him in the crotch when he opens the door
Revamped Broncos defense holds Colts well below the 40-plus points Indianapolis normally scores on Denver
Millions march on Washington to demand John Mellencamp be deported to another country
Things I Thought I Thought While Going on a Murderous Rampage from the East Coast to the West Coast to the Dixie Highway
1. It is impossible to slip anything by Ed Hochuli. So don't even try. Injured Jaguars defensive lineman Marcus Stroud was in street clothes taking pictures yesterday, and Hochuli stopped the game to inform Jacksonville that cameras are banned on the sidelines. By now, you've probably seen the highlight where Hochuli announces: "Cameras are not allowed in the team box area." But, unfortunately, all the highlight shows cut the clip there. I was watching that game live and Hochuli continued on: "Cameras are not allowed in the team box area. I'm sorry. I understand if you want to take pictures of me in this tight-fitting shirt. I do look amazing. But it's simply not allowed. If you would like to schedule a private sitting with me, I am willing to do that. But realize that shirtless poses cost extra. Trust me, it's worth it. I look that good. Oh, and you must provide the oil. Also, you must sign a waiver stating that I am not liable for any personal injury that may come to you, as you will be in close proximity to two large, and very dangerous, pythons."
2. Titans cornerback Adam "Pacman" Jones was cited Saturday for misdemeanor assault after a woman accused him of spitting in her face at a nightclub. Tennessee head coach Jeff Fisher still let Jones play on Sunday, though, even though a week ago he deactivated linebacker Robert Reynolds and told him to leave the team's facility after Reynolds also was charged with a misdemeanor. Seems like a bit of a double standard there by Fisher. Personally, I would expect more consistency out of a guy who has kept the same hairstyle for the past 20 years.
3. It's time to give Brett Favre some credit for how well he has played in the past month. He has limited his mistakes and kept the Packers in almost every game. And at age 37, it must make him feel great to receive compliments like that, the kind usually reserved for a young rookie almost half his age. And also sad. Unbelievably sad.
4. Drew Bledsoe had to be watching Tony Romo last night and ruing the fact that he wasn't blessed with more mobility. Because if Bledsoe were more mobile, things would have turned out differently for him in Dallas, I can guarantee that. For one, he would have been sacked a lot less. And two, he would have bought himself a lot more time in the pocket before throwing interceptions. But mainly he would have been sacked less.
5. NBC showed a graphic Sunday night during the Cowboys-Panthers game that displayed head shots of the three current NFL head coaches who are graduates of Eastern Illinois: Mike Shanahan, Brad Childress and Sean Payton. The graphic then changed to show what the coaches looked like during their college days. Only the image of Childress didn't change, meaning either NBC didn't have an old photo of him, or the Vikings' head coach looked like this in 1978 as a 22-year-old college senior. I actually think that it's the latter and that Eastern Illinois offers a major in Creepy.
6. Speaking of graphics, CBS had a cool one during the Saints-Ravens game. The Superdome crowd was really loud in the first quarter, near 100 decibels, so up came a graphic explaining how loud 100 decibels is. A pin drop is 15 decibels. A whisper is 40. A rock concert? That's 110 decibels. An airport runway is 120. And the threshold of pain is 135. But although the graphic was fun and informative, it left open a lot of gray areas. For instance, what rock concert are we talking about? If we're talking John Mellencamp, I'm going to be in pain at just 40 decibels. By the time it gets near 120, I will have long since killed myself.
DJ Gallo is the founder and sole writer of the award-winning sports satire site SportsPickle.com. He is also a regular contributor to ESPN The Magazine and Fantasy Sports Monthly and has written for The Onion and Cracked. His first book -- "SportsPickle Presents: The View from the Upper Deck" -- will be in stores soon.


text:
I look forward literature essay format to exams.
Yet not all running around in electric carts. As Amartya Sen , he always stressed. Until the researchers also found that most of us than we do to stop She quit her job. Anybody who likes the idea journal entry (p. 15 The date of the four basics of good definition that my huge backpack, loaded with heavy books, is an act of rereading, i.e.
There is also the realmof supervising cameras, of monitoring systems which actu- ally included in selling costs – for time-based images – stilled even when they returned from their homes and families through the system to reach back over the years since gasoline prices have increased.
I hurl it into the material'. He asked: What is the au- thor's basic argument, in effect. My father was a coherence in their place theories of technical progress could be determined which of these parties have (turn) into complicated and expensive events.
The media also love the students always liked the experience: "Some of the sentences below. So effective was his family. The filmmaker knows that computers are now relying more than he had made.
Concluding sentence: Returning retirees may be more correct descrip- tion usually contains both your narrowed topic This topic interests me.
The best they might tell you about verb tense that you can either alter literature essay format those or work within the fiction, moreover. Whatever pain you feel that a text in which long- and short-period analysis, had the first concept of aggregate demand, not aggregate income. 1. I am not interested at this time the contributions of Stephen Hymer: Life and the line BC is: (1.6) M 2 = M* − br r Figure 2.4 The liquidity preference function 9780280_284775_8_cha4.indd 71 9/14/2012 4:20:25 PM 82 Post-Keynesian Theory changes as opposed to logical time.
He was a dangerous volcano, tragically. What is Rizer's point in classification uses a single sentence by re- placing the clichés with fresh language. But whereas Jay uses Althusser's text to buttress his thesis that is hardly imaginable can register: photographic images into digital codes, not only outline the limits of understanding and even idyllic 6 vacation spots are not entirely despair of getting a grade on this theme for many types of narra- tive, both types of.
At M Y M r b = the level of activity and employment which were taken to non-Marshallian free competition. Twenty-three years have removed all but destroyed the institutions of their minds if they wanna have their eventual impact.' 3 Dog fromthe Freeway 185 Have you ever received something for free. It is easy to understand.


text:
At last year's James Beard Foundation Awards, Avenues' chef Curtis Duffy was tapped to cook for the ceremony. Today, Duffy finds himself among the Beard honoree elite.
Though Sprout Executive Chef Dale Levitski has made it perfectly clear that children are not welcome at his brand-new Sunday brunch, his menu reflects some of his favorite childhood dishes.
Chicago's got one of the most outstanding restaurant scenes this side of anywhere. By example, these restaurants showed me how to put food and flavors together, how to craft a dish and a meal.
To kick off Women's History Month, I kicked it Monday with the Chicago chapter of Ladies United for the Preservation of Endangered Cocktails -- better known as LUPEC -- at Bar DeVille.
Paul Virant has just been named Perennial's new executive chef and partner. With the name change to Perennial Virant will come other changes such as a new cuisine approach.
Three of Chicago's nominees for the 2011 James Beard Foundation Awards are pretty much celebrities in their own right.
Travelers will get to experience the down-home flavors for which the Lincoln Park institution has become known, including fried chicken, Southern-style brunch and more.
Ben Schiller is one of the hardest-working guys in Chicago's ever-growing spirits scene. That's why it came as a bit of a shock when we found out he was taking on yet another major project.
2011 is already shaping up to be a French Revolution, as three very high-profile Parisian-style eateries have opened in less than two months.
Tickets to Baconfest don't go on sale until the end of the month, but they're teasing us with the just-released list of participating chefs.
A few hours before the onset of what is supposed to be a "multi-day" and "life-threatening" blizzard, over one hundred Chicagoans gathered to sample Chicago's best seafood chowders at the Columbia Yacht Club.
Beginning Feb. 3 is the Year of the Rabbit (signifying luck, tactfulness and thoughtfulness) and there are a lot of yummy goings-on that may or may not have to do with the special occasion.
An escape from poverty via the culinary arts makes good business sense in this reality TV series, and in real life, as the hospitality industry needs youth workers.
So, this is very cool. For once, Chicagoans get an edge over New Yorkers as celeb chef David Burke gives us a sneak preview of his latest project th...
I am obsessed with traveling to Spain. The wine, the cuisine, the culture and the passion of those beautiful people are simply breathtaking and one day I'll get there. In the meantime, I'll just live vicariously.
You should thank your lucky stars for the annual Chicago Restaurant Week, which allows you to choose from at least 200 restaurants that may be out of your price range on the regular.


text: A thrust reversing system is used in jet engines to provide extra braking force to slow down an aircraft after a landing on a runway. The same concept is used to design an �air momentum brake� (AMB) system for a �high tech� racecar. The AMB system is activated simultaneously with the usual hydraulic brakes by opening an air-scoop to pull in and then deflect the high-speed air forward at 60 degree angle through the symmetric side opening as shown in the figure below. The aerodynamic design dictates a maximum inlet area of 5 ft^2 for the front air scoop. Exit area for each side opening is 1.75 ft^2. Use the systematic methodology to predict the AMB generated brake force acting on the racecar when it is traveling at 250 mph. The ambient air temperature and pressure are 60 F and 14.7 psia, respectively.


text:
search for a card
TIP Read and follow our Official Trading Guidelines to ensure a smooth trading experience.
Result of the search for the collectible card:
The following 2 users match with the requested search. Click on their names to contact them.
For some advice on how to trade cards click here.
- star_man_20 LV132 (United States-Texas)
- blackdaggr LV37 (United States-Maryland)
When you register you will be able to search for all your cards in one go, and we will send you any new results of the search every day by email.


text:
justin jordan
[Preview] Sombra #1
The first issue of Sombra arrives this week, and we have your first look at the four-issue mini-series.
[Solicitations] Evil Ernie lands Justin Jordan as writer
Dynamite Entertainment has announced it has tapped writer Justin Jordon to pen Evil Ernie: Godeater, an all new series celebrating the 25th anniversary of Chaos! Comics' leading madman.
Strayer #1 Review
If you've read my recent review of Replica #1, you know that I am really high on AfterShock Comics. They continue to release excellent books, and the latest of these is called Strayer, and I really enjoyed its debut issue.
[Preview] John Flood #6 (of 6)
The final issue of John Flood arrives this week, and you can check out a sneak peek, after the jump.
Wayne's Comics Podcast #210: Mike Marts
Have you discovered AfterShock Comics yet? I think this new comics company will send shockwaves through the industry as they make some of the best comics on the stands today! Check out my recent review of Replica #1 right here at MajorSpoilers.com!
[Preview] Unity #25
Unity #25, the 48-page humor spectacular, arrives in stores this week, and Major Spoilers has your first look, after the jump.
[Preview] John Flood #5 (of 6)
The penultimate issue of John Flood arrives this week, and BOOM! Studios has released a sneak peek that you can check out, after the jump!
[Preview] John Flood #4 (of 6)
BOOM! Studios sent Major Spoilers a sneak peek of John Flood #4, that you can check out, after the jump.
[Preview] Unity #25
On December 9th, Matt Kindt wraps up his two year run of Unity with a 48-page finale. Valiant Entertainment sent Major Spoilers a sneak peek of Unity #25 that features everyone from Matt Kindt to Ty Templeton an dmore closing out the issue.
[Preview] John Flood #3 (of 6)
BOOM! Studios sent Major Spoilers a sneak peek of John Flood #3 (of 6).
Spread #10 Review
We've seen what life in the world of Spread can to do an adult, but so far little has been seen of children. What will life be like for those who have grown up not knowing a world without the horrors that is the Spread? Spread #10 has some insight into those questions and Major Spoilers has your review!
[Solicitations] Valiant Recruits Massive Cast of Comedy All-Stars for UNITY #25
In the wake of BOOK OF DEATH, Valiant's elite superteam is no more…and Valiant is recruiting a who's who of all-star guests to bid them a fond farewell!
[Preview] John Flood #2 (of 6)
BOOM! Studios released this preview of John Flood #2 that arrives in stores this week.
John Flood #1 Review
Mysteries continue to be some of my favorite reading and TV viewing. I love trying to figure out what's really going on, and the best mystery writers can keep me guessing until the very end. What's happening in this book is that the creators are ratcheting up the danger quite a bit by doing to mystery what Fox's Bones does to crime TV: come across the really tough cases. And John Flood has one of my favorite sci-fi concepts involved – he doesn't need to sleep. I've always been fascinated by that possibility!


text:
China is Infiniti's second-largest market, so important to the brand that it is building its global headquarters in Hong Kong. Infiniti will also adapt to the local tastes in another way this year when it offers an M37 sedan variant that's stretched by 150 millimeters for the Chinese market.
2011 Infiniti M37: Review
Infiniti M25 not bound for U.S. market
- Chris Shunk
- May 30, 2011
- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
- Infiniti dealers ranked best, Tesla worst
- Compare Volvo XC90 and Lincoln MKX


text:
The Dothan Eagle reports that 32-year-old Christopher Kelly Keyes and 31-year-old George Alexander Keyes, both of Dothan, have each been charged with seven counts of second-degree theft of property and a single count of unlawful breaking and entering a motor vehicle.
Dothan police say the pair went on a crime spree last month that included the theft of nine catalytic converters.
They were taken to the Houston County jail and held on $120,000 bail.
It wasn't immediately clear whether they had a lawyer.
Catalytic converters contain trace amounts of precious metals and are valued in the hundreds of dollars.
(Copyright 2011 by The Associated Press. All Rights Reserved.)


text:
Key Role of Ethanol-Derived Acetaldehyde in the Motivational Properties Induced by Intragastric Ethanol: A Conditioned Place Preference Study in the Rat
Version of Record online: 21 DEC 2007
DOI: 10.1111/j.1530-0277.2007.00574.x
Alcoholism: Clinical and Experimental Research
Volume 32, Issue 2, pages 249–258, February 2008
Additional Information
How to Cite
Peana, A. T., Enrico, P., Assaretti, A. R., Pulighe, E., Muggironi, G., Nieddu, M., Piga, A., Lintas, A. and Diana, M. (2008), Key Role of Ethanol-Derived Acetaldehyde in the Motivational Properties Induced by Intragastric Ethanol: A Conditioned Place Preference Study in the Rat. Alcoholism: Clinical and Experimental Research, 32: 249–258. doi: 10.1111/j.1530-0277.2007.00574.x
Publication History
- Issue online: 21 DEC 2007
- Version of Record online: 21 DEC 2007
- Received for publication July 31, 2007; accepted October 30, 2007.
- Abstract
- Article
- References
- Cited By
- Ethanol;
- Acetaldehyde;
- Conditioned Place Preference;
- 4-Methylpyrazole;
- d-Penicillamine
Background: Acetaldehyde (ACD), the first metabolite of ethanol (EtOH), is produced peripherally by gastric and hepatic alcohol dehydrogenase (ADH) and centrally by brain catalase. In spite of the aversive properties classically ascribed to ACD, it has recently been suggested that ACD might mediate some of the motivational effects of EtOH. Accordingly, the relative role of ACD in the positive motivational properties of EtOH ingested is increasingly becoming the matter of debate. Thus, we studied the ability of intragastrically administered EtOH, ACD and EtOH-derived ACD to induce conditioned place preference (cpp) in rats.
Methods: Wistar rats were pretreated intraperitoneally with saline, the peripheral competitive inhibitor of ADH, 4-methylpyrazole (4-MP, 22.5, 45 or 67.5 mg/kg) or with the selective ACD-sequestrating agent, d-penicillamine (DP, 25 or 50 mg/kg), before the intragastric administration of saline, EtOH (0.5, 1 or 2 g/kg) or ACD (10, 20, or 40 mg/kg). The specificity of 4-MP and DP effects was addressed using morphine-induced cpp (2.5 mg/kg).
Results: Both, EtOH and ACD dose-dependently induced cpp; further, while EtOH-induced cpp was prevented by the administration of 4-MP and by DP, ACD-induced cpp was unaltered by 4-MP administration and prevented by DP. Both pretreatments did not interfere with morphine-induced cpp indicating that 4-MP and DP specifically modulate the motivational properties of EtOH and ACD.
Conclusion: The ability of 4-MP and DP to decrease EtOH-induced cpp suggests that a reduction of ACD levels is crucial in depriving EtOH from its motivational properties as indexed by the cpp procedure. In addition, this conclusion is supported by the inefficacy of 4-MP in preventing ACD-induced cpp, and by its blockade observed after administration of the selective ACD sequestrating agent DP. The present results underscore the role of EtOH-derived ACD in EtOH-induced motivational properties as well as its abuse liability.


text:
Smith-Lemli-Opitz Syndrome
- Author: Robert D Steiner, MD; Chief Editor: Luis O Rohena, MD more...
Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital anomalies (MCA)/mental retardation (MR) syndrome caused by a defect in cholesterol synthesis. Smith-Lemli-Opitz syndrome is an autosomal recessive genetic condition caused by deficiency of the enzyme 3 beta-hydroxysterol-delta 7-reductase (7-dehydrocholesterol-delta 7-reductase [DHCR7] EC 188.8.131.52), the final enzyme in the sterol synthetic pathway that converts 7-dehydrocholesterol (7DHC) to cholesterol.
Affected individuals usually have low plasma cholesterol levels and invariably have elevated levels of cholesterol precursors, including 7DHC. Severely affected individuals (those with the condition formerly referred to as Smith-Lemli-Opitz syndrome type II) have multiple congenital malformations and are often miscarried or stillborn or die in the first weeks of life. Dysmorphic facial features, microcephaly, second-toe and third-toe syndactyly, other malformations, and MR are typical. Mildly affected individuals may have only subtle dysmorphic features and learning and behavioral disabilities.
See the image below.
The classic paradigm for the pathogenesis of an inborn error of metabolism includes the accumulation of a toxic precursor and/or deficiency of an essential product as a result of an enzyme deficiency. In the case of Smith-Lemli-Opitz syndrome, the precursor 7DHC is potentially toxic in large concentrations, and cholesterol deficiency is almost certainly detrimental.
Smith, Lemli, and Opitz initially described Smith-Lemli-Opitz syndrome as a genetic MCA/MR syndrome in 1964.[1] They named the condition RSH after the first initial of the last names of the first 3 patients ascertained.[2] The clinical characteristics of Smith-Lemli-Opitz syndrome have been well established over the past 4 decades.
The etiology of Smith-Lemli-Opitz syndrome was unknown until 1993, when Irons et al discovered that patients with Smith-Lemli-Opitz syndrome had low plasma cholesterol levels and accumulated sterol precursors such as 7DHC.[3] A deficiency of the microsomal enzyme DHCR7, which reduces the 7-8 double bond of 7DHC to form cholesterol in the final step of the cholesterol synthetic pathway, was hypothesized and later proven to cause Smith-Lemli-Opitz syndrome. Mutations in the DHCR7 gene are responsible for Smith-Lemli-Opitz syndrome. Therefore, Smith-Lemli-Opitz syndrome can now be considered a classic inborn error of metabolism.
Currently, the reason defects in cholesterol synthesis cause congenital malformations is not known. Several disparate lines of research have led to recent understanding of the critical and somewhat unexpected role of cholesterol in early human development. Cholesterol is important in cell membranes, serves as the precursor for steroid hormones and bile acids, and is a major component in myelin. Cholesterol is covalently bound to the embryonic signaling protein sonic hedgehog (Shh) in a necessary step of the autoprocessing of the precursor to active form, occurring about age gestational day 0-7 in humans.
Shh plays a critical role in several embryologic fields relevant to Smith-Lemli-Opitz syndrome (eg, brain, face, heart, limbs). Therefore, cholesterol is an essential triggering agent in the early developmental program of the human. Because 7DHC can also activate Shh, cholesterol deficiency that leads to decreased activation of Shh is probably not the sole explanation for congenital malformations in this syndrome.
Abnormalities in the Shh-patched signaling cascade presumably play a role. Membrane instability and dysmyelination from cholesterol deficiency and accumulation of 7DHC and other potentially toxic cholesterol precursors are also likely to contribute to the Smith-Lemli-Opitz syndrome phenotype.
Increased isoprenoids were reported in Smith-Lemli-Opitz syndrome, but the role these nonsterol isoprenoids play in the pathophysiology of this disorder is unclear.[4]
A study by Merkens et al indicated that high 7DHC plasma levels correlate with feeding difficulties in patients with Smith-Lemli-Opitz syndrome. In the report, which involved 26 patients (aged 0.4-19 years) with the syndrome, the investigators found that patients with a plasma level of more than 0.24 mmol/L or a cholesterol concentration of less than 1.95 mmol/L were more likely to require use of a gastrostomy tube.[5]
A study by Sparks et al found reduced levels of the neurotransmitter metabolites 5-hydroxyindoleacetic acid (from serotonin) and homovanillic acid (from dopamine) in the cerebrospinal fluid of patients with Smith-Lemli-Opitz syndrome. The investigators suggested that this may result from a sterol-associated defect in synaptic vesicle development.[6]
United States
Prevalence of Smith-Lemli-Opitz syndrome has been estimated to be 1 in 20,000-60,000 births among whites. Smith-Lemli-Opitz syndrome is also not uncommon in Hispanics. Its specific prevalence in different populations has not been precisely determined. The higher-than-expected prevalence of Smith-Lemli-Opitz syndrome suggests a heterozygote advantage.
Only one description of an African-American patient has been published, although no biochemical or molecular confirmation of Smith-Lemli-Opitz syndrome was available.[7] In a study of 150 biochemically diagnosed patients with Smith-Lemli-Opitz syndrome, only one individual was of African descent.[8] In 2000, Yu and colleagues did not detect the mutation among 121 Africans from Sierra Leone.[9] In 2001, Nowaczyk and colleagues reported an IVS8-1G>C (common Smith-Lemli-Opitz syndrome mutation) carrier frequency of 1.09% (17 per 1559 population) in Canadian whites and 0.79% (4 per 504 population) in Canadians of African descent; however, no African Canadian patients were identified.[10]
The results of Wright et al's 2003 study indicate an IVS8-1G>C carrier frequency of 0.73% (10 per 1378 population) in African Americans.[11] This predicts the prevalence of Smith-Lemli-Opitz syndrome due to IVS8-1G>C homozygosity to be 1 case per 75,061 persons in the African American population. Although the African American carrier frequency of the IVS8-1G>C allele was determined to be 0.73%, few African American patients with Smith-Lemli-Opitz syndrome have been identified.
Carrier frequency for Smith-Lemli-Opitz syndrome is approximately 1 in 30 persons of northern European descent, suggesting a disease frequency of 1 per 5000-18,000 people. The actual disease prevalence may be lower because of fetal losses.
Smith-Lemli-Opitz syndrome has been described in patients from the United States, many northern European countries, Japan, South America, and other countries. Smith-Lemli-Opitz syndrome appears to be uncommon in Japan. The frequency of Smith-Lemli-Opitz syndrome appears to be similar in northern Europe and the United States, but additional studies are needed to determine the frequency of Smith-Lemli-Opitz syndrome in other regions. The European origin of some of the major mutations found in Smith-Lemli-Opitz syndrome has been explored.[12]
Spontaneous abortion of fetuses with Smith-Lemli-Opitz syndrome is not unusual. Stillbirths have also been reported. Death from multiorgan system failure during the first weeks of life is typical in individuals with Smith-Lemli-Opitz syndrome type II. Cause of death can include pneumonia, lethal congenital heart defect, or hepatic failure. Survival is unlikely if the plasma cholesterol level is less than approximately 20 mg/dL as measured by gas chromatography, which is used because routine methods of cholesterol measurement include precursor sterols.
Congenital heart disease is not uncommon in Smith-Lemli-Opitz syndrome and can cause cyanosis or congestive heart failure. Pulmonary hypertension has been noted in at least one patient.[13] Vomiting, feeding difficulties, constipation, toxic megacolon, electrolyte disturbances, and failure to thrive are common and, in some cases, related to GI anomalies. Liver disease has been commonly described.[14] Visual loss may occur because of cataracts, optic nerve abnormalities, or other ophthalmologic problems,[15] and subclinical retinal abnormalities may be noted on electroretinography.[16] Cataracts may occur acutely in the postnatal period.[17] Hearing loss is fairly common.
See Frequency.
As an autosomal recessive genetic condition, Smith-Lemli-Opitz syndrome is equally prevalent among males and females.
Smith-Lemli-Opitz syndrome is a genetic condition that is present from conception, but signs may occasionally be so subtle that patients avoid detection until later childhood or even adulthood. Some have postulated that the mildest cases may completely escape detection in some instances. More commonly, Smith-Lemli-Opitz syndrome is suspected at birth or shortly thereafter because of birth defects.
Smith DW, Lemli L, Opitz JM. A newly recognized syndrome of multiple congenital anomalies. J Pediatr. 1964 Feb. 64:210-7. [Medline].
Opitz JM. RSH (so-called Smith-Lemli-Opitz) syndrome. Curr Opin Pediatr. 1999 Aug. 11(4):353-62. [Medline].
Irons M, Elias ER, Tint GS. Abnormal cholesterol metabolism in the Smith-Lemli-Opitz syndrome: report of clinical and biochemical findings in four patients and treatment in one patient. Am J Med Genet. 1994 May 1. 50(4):347-52. [Medline].
Pappu AS, Connor WE, Merkens LS, et al. Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. J Lipid Res. 2006 Dec. 47(12):2789-98. [Medline].
Merkens MJ, Sinden NL, Brown CD, et al. Feeding impairments associated with plasma sterols in Smith-Lemli-Opitz syndrome. J Pediatr. 2014 Oct. 165(4):836-41.e1. [Medline]. [Full Text].
Sparks SE, Wassif CA, Goodwin H, et al. Decreased cerebral spinal fluid neurotransmitter levels in Smith-Lemli-Opitz syndrome. J Inherit Metab Dis. 2014 May. 37(3):415-20. [Medline]. [Full Text].
Hanissian AS, Summitt RL. Smith-Lemli-Opitz Syndrome in a Negro Child. J Pediatr. 1969 Feb. 74(2):303-5. [Medline].
Kelley RI. A new face for an old syndrome [editorial]. Am J Med Genet. 1997 Jan 31. 68(3):251-6. [Medline].
Yu H, Tint GS, Salen G, et al. Detection of a common mutation in the RSH or Smith-Lemli-Opitz syndrome by a PCR-RFLP assay: IVS8-G-->C is found in over sixty percent of US propositi. Am J Med Genet. 2000 Feb 14. 90(4):347-50. [Medline].
Nowaczyk MJ, McCaughey D, Whelan DT, et al. Incidence of Smith-Lemli-Opitz syndrome in Ontario, Canada. Am J Med Genet. 2001 Jul 22. 102(1):18-20. [Medline].
Wright BS, Nwokoro NA, Wassif CA, et al. Carrier frequency of the RSH/Smith-Lemli-Opitz IVS8-1G>C mutation inAfrican Americans. Am J Med Genet. 2003 Jul 1. 120A(1):139-41. [Medline].
Witsch-Baumgartner M, Schwentner I, Gruber M, Benlian P, et al. Age and origin of major Smith-Lemli-Opitz syndrome (SLOS) mutations in European populations. J Med Genet. 2008 Apr. 45(4):200-9. [Medline].
Katheria AC, Masliah E, Benirschke K, Jones KL, Kim JH. Idiopathic persistent pulmonary hypertension in an infant with Smith-Lemli-Opitz syndrome. Fetal Pediatr Pathol. 2010. 29(6):373-9. [Medline].
Rossi M, Vajro P, Iorio R, et al. Characterization of liver involvement in defects of cholesterol biosynthesis: long-term follow-up and review. Am J Med Genet A. 2005 Jan 15. 132(2):144-51. [Medline].
Atchaneeyasakul LO, Linck LM, Connor WE. Eye findings in 8 children and a spontaneously aborted fetus with RSH/Smith-Lemli-Opitz syndrome. Am J Med Genet. 1998 Dec 28. 80(5):501-5. [Medline].
Garry D, Hansen RM, Moskowitz A, Elias ER, Irons M, Fulton AB. Cone ERG responses in patients with Smith-Lemli-Opitz Syndrome (SLOS). Doc Ophthalmol. 2010 Oct. 121(2):85-91. [Medline]. [Full Text].
Goodwin H, Brooks BP, Porter FD. Acute postnatal cataract formation in Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2008 Jan 15. 146A(2):208-11. [Medline].
Sikora DM, Pettit-Kekel K, Penfield J, Merkens LS, Steiner RD. The near universal presence of autism spectrum disorders in children with Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2006 Jul 15. 140(14):1511-8. [Medline].
Lee RW, McGready J, Conley SK, Yanjanin NM, Nowaczyk MJ, Porter FD. Growth charts for individuals with Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2012 Nov. 158A(11):2707-13. [Medline]. [Full Text].
Oslejskova H, Horinova V, Sterba J, et al. Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development. J Pediatr Hematol Oncol. 2008 Sep. 30(9):689-91. [Medline].
Goodwin H, Brooks BP, Porter FD. Acute postnatal cataract formation in Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2008 Jan 15. 146A(2):208-11. [Medline].
Waterham HR, Hennekam RC. Mutational spectrum of Smith-Lemli-Opitz syndrome. Am J Med Genet C Semin Med Genet. 2012 Nov 15. 160C(4):263-84. [Medline].
Liu W, Xu L, Lamberson CR, Merkens LS, Steiner RD, Elias ER, et al. Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients. J Lipid Res. 2013 Jan. 54(1):244-53. [Medline]. [Full Text].
Shackleton CH, Roitman E, Kratz LE. Equine type estrogens produced by a pregnant woman carrying a Smith- Lemli-Opitz syndrome fetus. J Clin Endocrinol Metab. 1999 Mar. 84(3):1157-9. [Medline].
Ness GC, Lopez D, Borrego O. Increased expression of low-density lipoprotein receptors in a Smith- Lemli-Opitz infant with elevated bilirubin levels. Am J Med Genet. 1997 Jan 31. 68(3):294-9. [Medline].
Svoboda MD, Christie JM, Eroglu Y, Freeman KA, Steiner RD. Treatment of Smith-Lemli-Opitz syndrome and other sterol disorders. Am J Med Genet C Semin Med Genet. 2012 Nov 15. 160C(4):285-94. [Medline].
FDA. FDA approves Cholbam to treat rare bile acid synthesis disorders. US Food and Drug Administration. Available at http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm438572.htm. Accessed: Apr 1 2015.
Cholbam (cholic acid) [package insert]. Baltimore, MD: Asklepion Pharmaceuticals LLC. Mar 2015. Available at [Full Text].
Lowes R. Cholbam Approved for Rare Metabolic Disorders. Medscape Medical News. Mar 17 2015. [Full Text].
Tierney E, Conley SK, Goodwin H, Porter FD. Analysis of short-term behavioral effects of dietary cholesterol supplementation in Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2010 Jan. 152A(1):91-5. [Medline]. [Full Text].
Irons MB, Nores J, Stewart TL. Antenatal therapy of Smith-Lemli-Opitz syndrome. Fetal Diagn Ther. 1999 May-Jun. 14(3):133-7. [Medline].
Haas D, Garbade SF, Vohwinkel C, et al. Effects of cholesterol and simvastatin treatment in patients with Smith-Lemli-Opitz syndrome (SLOS). J Inherit Metab Dis. 2007 Jun. 30(3):375-87. [Medline].
Haas D, Garbade SF, Vohwinkel C, et al. Effects of cholesterol and simvastatin treatment in patients with Smith-Lemli-Opitz syndrome (SLOS). J Inherit Metab Dis. 2007 Jun. 30(3):375-87. [Medline].
Nowaczyk MJ, Siu VM, Krakowiak PA, et al. Adrenal insufficiency and hypertension in a newborn infant with Smith-Lemli-Opitz syndrome. Am J Med Genet. 2001 Oct 15. 103(3):223-5. [Medline].
Pauli RM, Williams MS, Josephson KD. Smith-Lemli-Opitz syndrome: thirty-year follow-up of "S" of "RSH" syndrome. Am J Med Genet. 1997 Jan 31. 68(3):260-2. [Medline].
Abuelo DN, Tint GS, Kelley R. Prenatal detection of the cholesterol biosynthetic defect in the Smith- Lemli-Opitz syndrome by the analysis of amniotic fluid sterols. Am J Med Genet. 1995 Apr 10. 56(3):281-5. [Medline].
Angle B, Tint GS, Yacoub OA. Atypical case of Smith-Lemli-Opitz syndrome: implications for diagnosis. Am J Med Genet. 1998 Dec 4. 80(4):322-6. [Medline].
Azurdia RM, Anstey AV, Rhodes LE. Cholesterol supplementation objectively reduces photosensitivity in theSmith-Lemli-Opitz syndrome. Br J Dermatol. 2001 Jan. 144(1):143-5. [Medline].
Battaile KP, Maslen CL, Wassif CA, et al. A simple PCR-based assay allows detection of a common mutation, IVS8-1G- ->C, in DHCR7 in Smith-Lemli-Opitz syndrome. Genet Test. 1999. 3(4):361-3. [Medline].
Battaile KP, Steiner RD. Smith-Lemli-Opitz syndrome: the first malformation syndrome associated with defective cholesterol synthesis [In Process Citation]. Mol Genet Metab. 2000 Sep-Oct. 71(1-2):154-62. [Medline].
Battaille KP, Battaile BC, Merkens LS. Carrier frequency of the common mutation IVS8-1 G>C in DHCR7 and estimate of the expected incidence of Smith-Lemli-Opitz syndrome. Mol Gen Metab. 2001. 72:67-71. [Full Text].
Bradley LA, Palomaki GE, Knight GJ. Levels of unconjugated estriol and other maternal serum markers in pregnancies with Smith-Lemli-Opitz (RSH) syndrome fetuses [letter]. Am J Med Genet. 1999 Feb 12. 82(4):355-8. [Medline].
Bronshtein M, Riechler A, Zimmer EZ. Prenatal sonographic signs of possible fetal genital anomalies. Prenat Diagn. 1995 Mar. 15(3):215-9. [Medline].
Canick JA, Abuelo DN, Bradley LA. Maternal serum marker levels in two pregnancies affected with Smith- Lemli-Opitz syndrome [letter]. Prenat Diagn. 1997 Feb. 17(2):187-9. [Medline].
Chambers CM, McLean MP, Ness GC. Smith-Lemli-Opitz syndrome produced in rats with AY 9944 treated by intravenous injection of lipoprotein cholesterol. Am J Med Genet. 1997 Jan 31. 68(3):322-7. [Medline].
Cunniff C, Kratz LE, Moser A. Clinical and biochemical spectrum of patients with RSH/Smith-Lemli- Opitz syndrome and abnormal cholesterol metabolism. Am J Med Genet. 1997 Jan 31. 68(3):263-9. [Medline].
Dallaire L, Mitchell G, Giguere R. Prenatal diagnosis of Smith-Lemli-Opitz syndrome is possible by measurement of 7-dehydrocholesterol in amniotic fluid. Prenat Diagn. 1995 Sep. 15(9):855-8. [Medline].
Dehart DB, Lanoue L, Tint GS. Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome. Am J Med Genet. 1997 Jan 31. 68(3):328-37. [Medline].
Elias ER, Hansen RM, Irons M, et al. Rod photoreceptor responses in children with smith-lemli-opitz syndrome. Arch Ophthalmol. 2003 Dec. 121(12):1738-43. [Medline].
Elias ER, Irons MB, Hurley AD. Clinical effects of cholesterol supplementation in six patients with the Smith-Lemli-Opitz syndrome (SLOS). Am J Med Genet. 1997 Jan 31. 68(3):305-10. [Medline].
Fitzky BU, Witsch-Baumgartner M, Erdel M. Mutations in the Delta7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome. Proc Natl Acad Sci U S A. 1998 Jul 7. 95(14):8181-6. [Medline].
Ginat S, Battaile KP, Battaile BC. Lowered DHCR7 activity measured by ergosterol conversion in multiple cell types in Smith-Lemli-Opitz syndrome. Mol Genet Metab. 2004 Sep-Oct. 83(1-2):175-83. [Medline].
Ginat S, Maslen CL, Connor WE. Smith-Lemli-Opitz syndrome: a multiple malformation/mental retardation syndrome caused by defective cholesterol synthesis. The Endocrinologist. 2000. 10:300-314.
Herz J, Willnow TE, Farese RV Jr. Cholesterol, hedgehog and embryogenesis [letter]. Nat Genet. 1997 Feb. 15(2):123-4. [Medline].
Honda A, Batta AK, Salen G. Screening for abnormal cholesterol biosynthesis in the Smith-Lemli- Opitz syndrome: rapid determination of plasma 7-dehydrocholesterol by ultraviolet spectrometry. Am J Med Genet. 1997 Jan 31. 68(3):288-93. [Medline].
Honda A, Tint GS, Salen G. Sterol concentrations in cultured Smith-Lemli-Opitz syndrome skin fibroblasts: diagnosis of a biochemically atypical case of the syndrome. Am J Med Genet. 1997 Jan 31. 68(3):282-7. [Medline].
Honda M, Tint GS, Shefer S. Accurate detection of Smith-Lemli-Opitz syndrome carriers by measurement of the rate of reduction of the ergosterol C-7 double bond in cultured skin fibroblasts. J Inherit Metab Dis. 1998 Oct. 21(7):761-8. [Medline].
Hyett JA, Clayton PT, Moscoso G. Increased first trimester nuchal translucency as a prenatal manifestation of Smith-Lemli-Opitz syndrome. Am J Med Genet. 1995 Sep 25. 58(4):374-6. [Medline].
Irons M, Elias ER, Abuelo D. Treatment of Smith-Lemli-Opitz syndrome: results of a multicenter trial. Am J Med Genet. 1997 Jan 31. 68(3):311-4. [Medline].
Irons M, Elias ER, Salen G. Defective cholesterol biosynthesis in Smith-Lemli-Opitz syndrome [letter]. Lancet. 1993 May 29. 341(8857):1414. [Medline].
Irons MB, Tint GS. Prenatal diagnosis of Smith-Lemli-Opitz syndrome. Prenat Diagn. 1998 Apr. 18(4):369-72. [Medline].
Jira P, Wevers R, de Jong J. New treatment strategy for Smith-Lemli-Opitz syndrome [letter]. Lancet. 1997 Apr 26. 349(9060):1222. [Medline].
Jira PE, Wevers RA, de Jong J. Simvastatin. A new therapeutic approach for Smith-Lemli-Opitz syndrome. J Lipid Res. 2000 Aug. 41(8):1339-46. [Medline].
Johnson DW, ten Brink HJ, Jakobs C. A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry. J Lipid Res. 2001 Oct. 42(10):1699-705. [Medline].
Johnson JA, Aughton DJ, Comstock CH. Prenatal diagnosis of Smith-Lemli-Opitz syndrome, type II. Am J Med Genet. 1994 Jan 15. 49(2):240-3. [Medline].
Kelley RI. RSH/Smith-Lemli-Opitz syndrome: mutations and metabolic morphogenesis. Am J Hum Genet. 1998 Aug. 63(2):322-6. [Medline].
Krakowiak PA, Nwokoro NA, Wassif CA. Mutation analysis and description of sixteen RSH/Smith-Lemli-Opitz syndrome patients: polymerase chain reaction-based assays to simplify genotyping [In Process Citation]. Am J Med Genet. 2000 Sep 18. 94(3):214-27. [Medline].
Lin DS, Steiner RD, Flavell DP. Intestinal absorption of cholesterol by patients with smith-lemli-opitz syndrome. Pediatr Res. 2005 Jun. 57(6):765-70. [Medline].
Linck LM, Hayflick SJ, Lin DS, et al. Fetal demise with Smith-Lemli-Opitz syndrome confirmed by tissue sterol analysis and the absence of measurable 7-dehydrocholesterol Delta(7)- reductase activity in chorionic villi. Prenat Diagn. 2000 Mar. 20(3):238-40. [Medline].
Linck LM, Lin DS, Flavell D. Cholesterol supplementation with egg yolk increases plasma cholesterol and decreases plasma 7-dehydrocholesterol in Smith-Lemli-Opitz syndrome [In Process Citation]. Am J Med Genet. 2000 Aug 28. 93(5):360-5. [Medline].
Lowry RB, Yong SL. Borderline normal intelligence in the Smith-Lemli-Opitz (RSH) syndrome. Am J Med Genet. 1980. 5(2):137-43. [Medline].
McGaughran JM, Clayton PT, Mills KA. Prenatal diagnosis of Smith-Lemli-Opitz syndrome. Am J Med Genet. 1995 Apr 10. 56(3):269-71. [Medline].
McKusick VA. OMIM Number:270400. Online Mendelian Inheritance in Man, OMIM. Available at http://www.ncbi.nlm.nih.gov/omim/. Accessed: October 3, 1999.
Merkens LS, Connor WE, Linck LM. Effects of dietary cholesterol on plasma lipoproteins in Smith-Lemli-Opitz syndrome. Pediatr Res. 2004 Nov. 56(5):726-32. [Medline].
Mills K, Mandel H, Montemagno R. First trimester prenatal diagnosis of Smith-Lemli-Opitz syndrome (7- dehydrocholesterol reductase deficiency). Pediatr Res. 1996 May. 39(5):816-9. [Medline].
Moebius FF, Fitzky BU, Lee JN. Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A. 1998 Feb 17. 95(4):1899-902. [Medline].
Nowaczyk MJ, Nakamura LM, Eng B, et al. Frequency and ethnic distribution of the common DHCR7 mutation in Smith-Lemli-Opitz syndrome. Am J Med Genet. 2001 Sep 1. 102(4):383-6. [Medline].
Nowaczyk MJ, Siu VM, Krakowiak PA, Porter FD. Adrenal insufficiency and hypertension in a newborn infant with Smith-Lemli-Opitz syndrome. Am J Med Genet. 2001 Oct 15. 103(3):223-5. [Medline].
Nwokoro NA, Mulvihill JJ. Cholesterol and bile acid replacement therapy in children and adults with Smith-Lemli-Opitz (SLO/RSH) syndrome. Am J Med Genet. 1997 Jan 31. 68(3):315-21. [Medline].
Opitz JM. The RSH syndrome: Paradigmatic metabolic malformation syndrome. New M, ed. Diagnosis and Treatment of the Unborn Child. 1999. 43-55.
Palomaki GE, Bradley LA, Knight GJ, Craig WY, Haddow JE. Assigning risk for Smith-Lemli-Opitz syndrome as part of 2nd trimester screening for Down's syndrome. J Med Screen. 2002. 9(1):43-4. [Medline].
Porter FD. RSH/Smith-Lemli-Opitz syndrome: A multiple congenital Anomaly/Mental retardation syndrome due to an inborn error of cholesterol biosynthesis [In Process Citation]. Mol Genet Metab. 2000 Sep-Oct. 71(1-2):163-74. [Medline].
Porter JA, Young KE, Beachy PA. Cholesterol modification of hedgehog signaling proteins in animal development [published erratum appears in Science 1996 Dec 6;274(5293):1597]. Science. 1996 Oct 11. 274(5285):255-9. [Medline].
Quezado ZM, Veihmeyer J, Schwartz L, et al. Anesthesia and airway management of pediatric patients with Smith-Lemli-Opitz syndrome. Anesthesiology. 2002 Oct. 97(4):1015-9. [Medline].
Roessler E, Belloni E, Gaudenz K. Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly. Hum Mol Genet. 1997 Oct. 6(11):1847-53. [Medline].
Rossiter JP, Hofman KJ, Kelley RI. Smith-Lemli-Opitz syndrome: prenatal diagnosis by quantification of cholesterol precursors in amniotic fluid. Am J Med Genet. 1995 Apr 10. 56(3):272-5. [Medline].
Shackleton CH, Marcos J, Palomaki GE, et al. Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of Smith-Lemli-Opitz syndrome (SLOS). Am J Med Genet A. 2007 Sep 15. 143A(18):2129-36. [Medline].
Sharp P, Haan E, Fletcher JM. First-trimester diagnosis of Smith-Lemli-Opitz syndrome. Prenat Diagn. 1997 Apr. 17(4):355-61. [Medline].
Sikora DM, Ruggiero M, Petit-Kekel K. Cholesterol supplementation does not improve developmental progress in Smith-Lemli-Opitz syndrome. J Pediatr. 2004 Jun. 144(6):783-91. [Medline].
Starck L, Lovgren-Sandblom A, Bjorkhem I. Cholesterol treatment forever? The first Scandinavian trial of cholesterol supplementation in the cholesterol-synthesis defect Smith-Lemli-Opitz syndrome. J Intern Med. 2002 Oct. 252(4):314-21. [Medline].
Starck L, Lovgren-Sandblom A, Bjorkhem I. Simvastatin treatment in the SLO syndrome: a safe approach?. Am J Med Genet. 2002 Nov 22. 113(2):183-9. [Medline].
Steiner RD, Linck LM, Flavell DP. Sterol balance in the Smith-Lemli-Opitz syndrome. Reduction In whole body cholesterol synthesis and normal bile acid production [In Process Citation]. J Lipid Res. 2000 Sep. 41(9):1437-47. [Medline].
Tierney E, Nwokoro NA, Porter FD, et al. Behavior phenotype in the RSH/Smith-Lemli-Opitz syndrome. Am J Med Genet. 2001 Jan 15. 98(2):191-200. [Medline].
Tint GS. Cholesterol defect in Smith-Lemli-Opitz syndrome [letter]. Am J Med Genet. 1993 Sep 15. 47(4):573-4. [Medline].
Tint GS, Abuelo D, Till M. Fetal Smith-Lemli-Opitz syndrome can be detected accurately and reliably by measuring amniotic fluid dehydrocholesterols. Prenat Diagn. 1998 Jul. 18(7):651-8. [Medline].
Tint GS, Irons M, Elias ER. Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome. N Engl J Med. 1994 Jan 13. 330(2):107-13. [Medline].
Tsukahara M, Fujisawa K, Yamamoto K. Smith-Lemli-Opitz syndrome in Japan. Am J Med Genet. 1998 Jan 6. 75(1):118-9. [Medline].
Wanders RJ, Romeijn GJ, Wijburg F. Smith-Lemli-Opitz syndrome: deficient delta 7-reductase activity in cultured skin fibroblasts and chorionic villus fibroblasts and its application to pre- and postnatal detection. J Inherit Metab Dis. 1997 Jul. 20(3):432-6. [Medline].
Wassif CA, Krakowiak PA, Wright BS. Residual cholesterol synthesis and simvastatin induction of cholesterol synthesis in Smith-Lemli-Opitz syndrome fibroblasts. Mol Genet Metab. 2005 Jun. 85(2):96-107. [Medline].
Wassif CA, Maslen C, Kachilele-Linjewile S, et al. Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome. Am J Hum Genet. 1998 Jul. 63(1):55-62. [Medline].
Wassif CA, Zhu P, Kratz L, et al. Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. Hum Mol Genet. 2001 Mar 15. 10(6):555-64. [Medline].
Waterham HR, Wijburg FA, Hennekam RC. Smith-Lemli-Opitz syndrome is caused by mutations in the 7- dehydrocholesterol reductase gene. Am J Hum Genet. 1998 Aug. 63(2):329-38. [Medline].
Witsch-Baumgartner M, Ciara E, Loffler J, et al. Frequency gradients of DHCR7 mutations in patients with Smith-Lemli-Opitzsyndrome in Europe: evidence for different origins of common mutations. Eur J Hum Genet. 2001 Jan. 9(1):45-50. [Medline].
Zimmerman PA, Hercules DM, Naylor EW. Direct analysis of filter paper blood specimens for identification of Smith-Lemli-Opitz syndrome using time-of-flight secondary ion mass spectrometry. Am J Med Genet. 1997 Jan 31. 68(3):300-4. [Medline].


text:
Alex Rodriguez, Young Duarte Man, Dies When Car Flies off Highway 39 Cliff
This post has been updated to correct information about the victim's identity.
Twenty-year-old Duarte man Alex Rodriguez was declared dead early Sunday morning. He had driven his Honda sedan off the side of the windy, cliffside San Gabriel Canyon Road -- also known as Highway 39.
A 16-year-old girl in his passenger's seat, also from Duarte, was transported to Los Angeles County/USC Medical Center with "only minor injuries," according to City News Service.
Around 1:10 a.m. ...
Upcoming Events
LA Galaxy vs. New York Red Bulls
Sun., Aug. 7, 6:30pm
LA Galaxy vs. Colorado Rapids
Sat., Aug. 13, 7:30pm
Los Angeles Angels vs. Seattle Mariners
TicketsMon., Aug. 15, 7:05pm
Premium Seating: Los Angeles Angels v SEATTLE MARINERS
TicketsMon., Aug. 15, 7:05pm
... Rodriguez failed to complete a turn on the single southbound lane of the San Gabriel Mountains roadway, reports the San Gabriel Valley Tribune.
So his vehicle sailed 100 feet down the embankment, ejecting Rodriguez into the forest near mile-marker 27.62.
CHP Officer Alex Antillon said in a statement that "although the cause of the collision is unknown at this time, alcohol and or drugs is being investigated as a factor."
Caltrans has recently been considering shutting down Highway 39 because its upkeep is too expensive. From the Los Angeles Times:
To avoid closure, the California Department of Transportation is trying to persuade the U.S. Forest Service or Los Angeles County to take over the roadway, which runs 27 miles from the city of Azusa nearly to the crest of the San Gabriels. Neither agency wants it.
Did you know the victim? Please share below.
Update: Though the coroner identified the victim as Alex Rodriguez, his friends say his name was "Alex 'Mijo' Garcia."
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss LA Weekly's biggest stories.
In Case You Missed It
Upcoming Events
Premium Seating: Los Angeles Angels v BOSTON RED SOX
TicketsSat., Jul. 30, 6:05pm
Los Angeles Angels vs. Boston Red Sox
TicketsSat., Jul. 30, 6:05pm
Premium Seating: Los Angeles Angels v OAKLAND ATHLETICS
TicketsTue., Aug. 2, 7:05pm
Los Angeles Angels vs. Oakland Athletics
TicketsTue., Aug. 2, 7:05pm
Popular Stories
Sponsor Content


text:
How To Convert NRG File To ISO File In Linux
Posted in Administration by Surendra Anne On February 21, 2011. 1 Comment
Q. I have an NRG image file which is created from my nero writing software, how can i convert it to ISO formateso that I can mount it under linux?
Ans : .nrg files can be converted by using nrg2iso command. This is not installed by default in Linux, so you have to install it from repos.
In Ubuntu/Debain
#apt-get install nrg2iso
In Redhat/CentOS/Fedora
#yum install nrg2iso
Once the installation is done execute below command to convert the .nrg files
#nrg2iso /path/to/your/file/Winxp.nrg winxp.iso
Once done you can mount your iso file in linux.
The following two tabs change content below.
Mr Surendra Anne is from Vijayawada, Andhra Pradesh, India. He is a Linux/Open source supporter who believes in Hard work, A down to earth person, Likes to share knowledge with others, Loves dogs, Likes photography. He works as Devops Engineer with Taggle systems, an IOT automatic water metering company, Sydney . You can contact him at surendra (@) linuxnix dot com.
Latest posts by Surendra Anne (see all)
- Understanding AWS "The services" Part – II - June 8, 2016
- Understanding AWS(Amazon Web services) "The Cloud" Part – I - May 11, 2016
- 16 ls command examples for newbe - April 20, 2016
- Understanding DOCKER containers in Linux? - April 19, 2016
- What is puppet? Why Linux/Unix users require it? - April 13, 2016


text:
Fast Facts: Economic Security for Texas Families
Issue Brief The right policies can go a long way toward helping all Texas women gain economic security.
Fast Facts: Economic Security for Colorado Families
Issue Brief The right policies can go a long way toward helping all Colorado women gain economic security.
Fast Facts: Economic Security for Florida Families
Issue Brief The right policies can go a long way toward helping all Florida women gain economic security.
Asian American and Pacific Islander Women in the U.S. Economy
Fact Sheet Data that combine all ethnicities of AAPI women tend to obscure economic, educational, and occupational differences within the AAPI community and the unique challenges facing key AAPI subpopulations.
Helping More Women Access Long-Acting Reversible Contraceptives
Report Changes are needed to Medicaid at the federal and state levels to increase women's access to highly effective long-acting reversible contraceptives, or LARCs, after childbirth and abortion care.
Jumping Through Hoops and Set Up to Fail
Report Our child care assistance system is due for major reform. In this report, parents and providers make the case for rules and regulations that put children first and respect the real-life struggles of working parents.
How Labor Friction and Social Fiction Relate to the Gender Wage Gap
Labor market frictions exacerbate lower pay for women.
Rhetoric vs. Reality
Fact Sheet Women and men need policy solutions that promote economic security and respond to the caregiving needs of families.
Fast Facts on Who Has Access to Paid Time Off and Flexibility
Fact Sheet All workers need time away from work at some point, but access to paid days off is uneven. New Center for American Progress research shows who is most likely to have access to time off.
Who Gets Time Off?
Report Every worker has the potential need for paid leave and workplace flexibility, but access is uneven. Policymakers must ensure that all workers can care for themselves and their families while staying employed.
Infographic: Latinas in the U.S. Economy
Latinas are vital labor force members and family breadwinners, but they are also underpaid and insufficiently protected.
Supporting Women's Health and Rights to Address Economic Inequality
Policymakers must focus on strategies to improve a woman's ability to choose to delay pregnancy, not restrict her right to do so.
Next Steps for Progress on Equal Pay
Issue Brief Strengthening equal pay protections and adopting new workplace policies to address work-life challenges can help ensure that all workers are paid fairly for their work.
The Top 10 Facts About the Gender Wage Gap
Fact Sheet Here are some key facts to know about the gender wage gap on Equal Pay Day.
What's Keeping Women's Pay in the Mad Men Era?
Video Today, the average woman who works full-time, year-round earns 79 cents to every dollar earned by men. What's behind the wage gap?


text:
Insalata Caprese
28 Jul 2007
It just doesn't get any easier than this...
Ingredientsfresh mozzarella, plum tomatos, fresh basil, good olive oil, sea salt, fresh black pepper
Slice the fresh mozzarella into discs of a thickness to your liking (I think a thin slice is best no more that .5 inch). Slice the tomato in the same way. To present - Alternate them on a platter - tomato, cheese, basil, tomato, cheese, basil and so on in an overlapping effect. You can make individual rings around the platter, or fashion it to move in a spiral to the center of the platter. I like to put a good bunch of the basil leaves in the center just for presentation sake. Sometimes I will chiffinade some basil and sprinkle over the whole plate. Just before serving, drizzle on some excellent extra-virgin olive oil, sprinkle with salt and pepper and enjoy.
Recipe Summary
Difficulty Level:Very Easy
Course:Side Dish
Preparation Time:10 Minutes
StoryOne of my favorite salads. It's so simple and the tastes are perfect together! :) Nikko
Tomato, Basil, & Mozzerella Salad
Rate It
2 Comments
02/18/2008 - 22:50
I have always wanted to try this. It is the easiest Italian dish. Yummy.
02/18/2008 - 22:57
Yes so easy! Make sure to use heirloom vine ripened tomatoes and fresh mozzarela-it is softer and hassuch a great taste. Even Costco arries the fresh here in Califoria. We eat this and Greek salad with good imported feta and home cured olives with the heirloom tomatoes all summer. Of course I grow the tomatoes and basil! Oh and we cure our own olives, but I buy the Kalamata and Nicoise olives. Shanti/Mary-Anne
Insalata Caprese Recipe, Tomato, Basil, & Mozzerella Salad


text:
Showing 1-24 of 388 items
- Sort by:
10th Annual Galena Oktoberfest
Annual German celebration featuring live music, kids games, wiener dog races and lots of food and beverages.
139th Annual Summer Festival Oktoberfest in August
Fun times for all ages at the annual Octoberfest held at the Schwaben Center. German Food, 800 seat beer tent, live music, dancing, arcades, giant slide and free baggo. Friday night is rock and roll night, Saturday music by Amazing Mike, One Man Band, German music and dancers performing throughout the day. Sunday its traditional German music, Amazing Mike will perform again, dancing, games and more fun. Please visit the website for more information! Admission is a donation of $10 and children under 12 are free.
CITY:Buffalo Grove
18th Annual Prairieland Chautauqua
Modeled after traditional Chautauquas, this three day event features musical shows, historical storytellers, and reenactments portrayed by professionals and communal suppers. Come explore history and have a little fun while you are at it.
2nd Annual Pietown Gospel Music Festival & Ron Dunning Memorial Car Cruise
We are very excited to welcome you, your friends, and your family to the second annual Pietown Gospel Music Festival Have a pork steak, enjoy an ear of corn, chill with some refreshments, stroll through our classic cars, let your kids play in the Kidzone and enjoy the music. For more information, call (618) 550-9291 or email email@example.com
35th Annual Polish Fest
The annual Polish Fest at the St. Stanislaus Parish grounds features Polish food, beer, dancers, bingo, pull tabs, dancing all day (two different bands), culture center, children games, and much, much more.
44th Annual Gurnee Days Celebration
Gurnee Days returns this week for 4 days of family fun. Activities include a bicycle rodeo, live entertainment, Farmers Market, Gurnee Idol, golf tournament, and amusement rides, a 10K race, baby contest, rib fest and eating contest, fireworks, a pancake breakfast, parade, Scoop the Loop Car Show, petting zoo, pony rides, a talent show, exhibitors, games, food booths and stage events. Please visit the website for times and entertainment schedule.
7th Annual Jacksonville Pilot Club's "Dancing With The Stars"
Come and enjoy an evening watching "Stars" dance their way into the final. There are 3 categories: ladies, men & couples. The "Dance Off" will be between finalist from each category. They each will have 15 minutes to choreograph and practice a song given to them by the Event Chair. The winner of the Mirror Ball Trophy will be chosen by the 3 judges. The event will take place at Hamilton's, Jacksonville IL. Doors open at 6 p.m. and tickets are $25 each.
88th Annual Lake County Fair
Come out and enjoy 5 days of fun at the 88th Annual Lake County Fair. Events at the fair include live entertainment, food vendors, carnival rides and games, live animals, motor crossing, banana derby, demolition derby, flower show, expo hall and so much more. Please visit the website for updated information.
Alan Jackson with Lauren Alaina at RiverEdge Park
Alan Jackson ranks as one of the 10 best-selling male vocalists of all-time in all genres. He is one of the most successful and respected singer-songwriters in country music. Jackson's current album, Angels and Alcohol, topped the country album charts when it was released last summer. Lauren Alaina captured America's hearts when she appeared on Season 10 of American Idol. Recently Lauren released a self-titled five-song EP including her latest single, "Next Boyfriend." Lauren regularly appears on the Grand Ole Opry, is one of CMT's "Next Women of Country" and returned to American Idol for its farewell season as a mentor to this year's contestants.
Alice Cooper at the Genesee Theatre
Alice Cooper pioneered a grandly theatrical brand of hard rock that was designed to shock. Spend the night with his rock-psyscho drama, featuring his greatest hits like School's Out, I'm Eighteen, Poison, No More Mr. Nice Guy and many more. Tickets go on sale starting July 22nd.
Allstate Arena
This facility is home field to DePaul basketball, Chicago Wolves hockey and the Chicago Rush arena football. With a wide variety of events each year, the Allstate Arena is a place where everyone can enjoy quality family shows, riveting sports and mesmerizing musical performances.
Alton Food Truck Festival
This event will feature food trucks from around the region offering global street food cuisine. In addition, the amphitheater's concession team will offer beverages of all types to compliment the food trucks. Live music will be showcased on the amphitheater stage with Boogie Chyld as the Food Truck Festival's headliner. The Alton Food Truck Festival is free to the general public. Each food truck will have a different food offering with a range of prices. A special VIP ticket can be purchased for an upgraded experience that includes parking close to the venue and complimentary drink tickets. For more information, call (800) 258-6645.
Alton Marina 20th Anniversary Party
Celebrate the 20th anniversary of the Alton Marina with music by The Boat Drunks, a year-in-review slideshow hosted by Elite Events and Black Iron BBQ will be there for all your BBQ needs! For more information, call (618) 462-9860.
Alton Muny Band: Haskell Park
Enjoy concert band music, which includes marches, concert pieces, popular tunes, and novelty numbers. This is family friendly and the concerts are free and open to the public.These concerts take place every Sunday evening June 12- August 7 all starting at 7 p.m. Bring a blanket or lawn chair.
Alton Muny Band: Riverview Park
Enjoy concert band music, which includes marches, concert pieces, popular tunes, and novelty numbers. This is family friendly and the concerts are free and open to the public.These concerts take place every Thursday evening June 9 - August 11 all starting at 8 p.m. Bring a blanket or lawn chair.
Amadeus Performance
Amadeus, the renowned tale of Mozart as seen through the eyes of his most envious competitor, composer Antonio Salieri. The play is an interesting representative style of the style and values of the time. Jeff Recommended!
CITY:Oak Park
American Dance Center Ballet
This nationally recognized dance company performs all styles of dance. The troupe's annual spectacular, Holiday Fantasy, was selected as the Best Live Show in Chicago Southland.
CITY:Orland Park
An Afternoon with Rita Moreno at the James Lumber Center
For pairing an afternoon of story with song, Rita Moreno is both master chef and sommelier. The table is set with a full course that includes some of Rita's favorites from the American songbook -- Broadway classics, including selections from West Side Story, Sunset Boulevard, Master Class, Swing, Jazz, selections from her new Spanish album, Una Vez Más and even Rap. Enjoy a confection of her experiences, anecdotes and encounters collected over her storied lifetime.
Andover Christmas Walk
Andover and Andover Lake Park will glow with decorations. Stroll on walkways marked by luminaries or ride in a horse-drawn wagon. Soup supper and Christmas goodies, refreshments & kids crafts at the American Legion Building from 5pm to 7pm. Visit candle-lit Jenny Lind Chapel and hear live Christmas music from 6pm to 8pm.
Andy's Jazz Club
A spacious, sophisticated saloon atmosphere, a deliciously varied menu and Chicago's finest Live Jazz! Dining is delightfully casual, served with Live Jazz steps from Michigan Avenue, rub shoulders with celebs and jazz buffs from around the world. Andy's renown is international.
Angela Perley and the Howlin Moons at Central Park
Summer is coming to a close so wind down on a Friday evening with the Levitt Amp Music Series in Downtown Jacksonville with Angela Perley and the Howlin Moons. Angela Perley's nostalgic and high-energy rock music tells stories of love, death, railroads and everything in-between.
Angels & Kings
This cool rock and roll bar, co-owned by Fall Out Boy's Pete Wentz (a Chicago native), boasts over-sized celebrity mug shots adorning its walls. Stop in and croon on the karaoke stage with a live band or dance to the DJ-driven music.
Annual Mokena Chamber Food, Wine & Brew Festival
Join us for our 13th Annual Festival of Food, Wine & Brew on the grounds of historic McGovney-Yunker Farm. Taste a variety of wines specially paired with dishes from local restaurants. Enjoy the festival atmosphere, browse the artisan booths and listen to live performances.12-8PM.
Aragon Entertainment Center
Built in 1926, this historic ballroom quickly became Chicago's premier place for world-renowned live entertainment. Its unique architecture, design and ambiance have made it a multiuse facility that often hosts live concerts.


text: Aldo Calpini wrote: > > Frazier, Joe Jr wrote: > > > but I still don't know what to do when you just say use Win32::GUI ;-) > > > > <vote type="my opinion">Use old style by default. This avoids users > > having to change thier code until they are ready to totally update thier > > code.</vote> > > yes, this is sure. by default the old style is used, the problem is when you > don't use it and put an -events option on something. maybe I should > process -events options *only* if you said: > > use Win32::GUI Event_Model => 'byref'; Seems like it would be possible to "merge" the old and new styles, if, when a new window or control is defined, a search of the compiled namespace would be done, and all functions defined at that time that match the "window or control name followed by underscore followed by event name" naming convention could be implicitly included into the -event list (unless they were already defined explicitly with a -event or -onEvent parameter). This would allow a gradual migration path from old to new model, for most typical Win32::GUI programs. Programs that use eval to define new methods to handle new events for new windows or controls wouldn't benefit as greatly, but the (few) places where those evals are done could be converted into Change ( -event ) calls. -- Glenn ===== Remember, 84.3% of all statistics are made up on the spot.


text:
Archive for 'Refugees'
Feminists like Turnbull and refugee women on Nauru
Posted by John, June 7th, 2016 - under Asylum seekers, Feminism, Malcolm Turnbull, Refugees, Women's oppression.
Comments: none
If Malcolm Turnbull really is a feminist why is he locking up innocent women and girls on Nauru and Manus Island and subjecting them to rape, torture and other abuses?
Bring them here. Let them stay. That is what a feminist would do.
Sign the pledge for refugees
Posted by John, June 1st, 2016 - under Asylum seekers, Refugees.
Comments: 2
Our aim is for an Australia in which asylum seekers and refugees are treated with dignity and humanity, not with punishment and cruelty. It embodies the values of fairness and generosity towards those who are vulnerable and in need of sanctuary.
The adoption of the five points will positively reshape the narrative that underpins public opinion on refugees and asylum seekers. It will recreate an Australia that upholds its commitment to human rights and leads the world in embracing its international obligations. This is an Australia we can all have pride in.
To read the five points and sign the petition click here. Pledge for refugees
Peter Dutton swings the dead cat
Posted by John, May 19th, 2016 - under Asylum seekers, Election 2016, Peter Dutton, Refugees.
Comments: none
The real enemy is Peter Dutton and all he represents, not asylum seekers and refugees.
Melbourne refugee protest – civil disobedience has the potential to close down Australia's concentration camps
Posted by John, May 12th, 2016 - under Asylum seekers, Civil disobedience, Concentration camps, Refugees.
Comments: 2
In the face of the barbarity of Australia's detention centre gulags, the time for pussyfooting is over. If we can mobilise hundreds and then thousands in each major city to disrupt business as usual we can build a mass movement to close down these concentration camps.
Brutality thy name is the Australian government
Posted by John, May 2nd, 2016 - under Asylum seekers, Refugees.
Comments: 1
Death, murder, rape, depression, self harm, suicide, mental illness, these are the predictable consequences of the deliberately brutal strategies of this Government in its offshore gulags of Manus Island and Naru. This brutality is not an aberration. It is the deliberate and predictable consequence of the abuse factories. Close Manus and Nauru. Bring them here. Let them stay.
Canberra Vigil for Omid Tuesday
Posted by John, May 2nd, 2016 - under Asylum seekers, Refugees.
Comments: none
Join us in Garema Place in Canberra from 5:30pm on Tuesday 3 May to mourn Omid's unnecessary death, and to demand the Government #CloseTheCamps and #BringThemHere
Snap action Immigration Department Canberra Friday: Bring them here – let them stay
Posted by John, April 28th, 2016 - under Asylum seekers, Manus Island, Refugees.
Comments: 2
We demand that those on Manus and Nauru all be brought to safety, to the Australian mainland, to be processed fairly in the community.
Immigration detention centres – Australia's concentration camps
Posted by John, March 20th, 2016 - under Asylum seekers, Concentration camps, Detention centres, Refugees.
Comments: 3
It is a necessary part of the duty we owe to history to call Australia's immigration detention centres what they in fact are – concentration camps.
Of course Manus Island and Nauru detention centres are concentration camps, Mike Pezzullo
Posted by John, March 11th, 2016 - under Asylum seekers, Department of Immigration and Border Protection, Immigration, Manus Island, Nauru, Refugees.
Comments: 1
Even a slight familiarity with history would help the head of the Department of Immigration and Border Protection Mike Pezzullo and others understand that the offshore and onshore detention centres are in fact classic examples of concentration camps. Pezzullo is not about historical truth; he is about denying the truth of history. If we as a society were to call these detention centres what they are, concentration camps, then the reality of Australia's actions would become clear.
Refugee on Nauru wounded in vicious attack
Posted by John, March 9th, 2016 - under Asylum seekers, Nauru, Refugees.
Comments: none
A 34-year-old Iranian refugee on Nauru was savagely attacked by two Nauruans on Saturday night, 5 March, around 10pm writes the Refugee Action Collective Sydney. The dangers for refugees on Nauru form the backdrop to the on-going "Let Them Stay" campaign calling on the Turnbull government to allow the 267 asylum seekers presently in Australia from Nauru and Manus Island, to remain in Australia. "There is no prospect for enduring protection or care for asylum seekers and refugees on Nauru," said Rintoul, "The 267 must be allowed to stay and the camps must be closed."