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RELEASE: A User's Guide to the Fiscal Year 2015 Defense Budget
Contact: Anne Shoup
Phone: 202.481.7146
Washington, D.C. — Today, just ahead of the National Defense Authorization Act markup next week, the Center for American Progress released a new report that clarifies and extrapolates on the decisions made within the 2015 fiscal year defense budget.
"The Pentagon should be commended for making a number of smart choices in its FY 2015 budget request, choices that will enhance our security while adhering to the Budget Control Act of 2011," said Lawrence J. Korb, Senior Fellow at the Center for American Progress. "However, its program for the FY 2016–2019 period will not meet the challenges of the current national security environment because it incorrectly assumes defense spending will return to the record high levels that characterized the decade after 9/11 and therefore risks triggering another sequester."
The report explains the U.S. Department of Defense's FY 2015 budget request and outlines a sound path to responsibly and efficiently meet the risks and challenges of the current national security environment. There are several smart, targeted reforms that will maintain U.S. military capabilities such as a $26 billion Opportunity, Growth and Security Initiative, as well as a base budget request of $496 billion.
The report offers the following recommendations for Congress and the U.S. Department of Defense:
- Reduce procurement of the littoral combat ship, or LCS, on the front end by nixing one of the variants—the current reduction from 52 to 32 hulls comes outside the Future Years Defense Program, or FYDP—which will free up funds to develop a new small surface combatant with more firepower in line with a frigate.
- Bring F-35 STOVL procurement down to two airframes per year until the hardware problems and software development are worked out; this echoes the decision made on the F-35C, which faces similar hurdles. The high level of concurrency makes no sense in the absence of an existential threat and the continuing viability of legacy platforms and will increase the need for expensive upgrades and alterations later.
- Authorize a Defense Base Closure and Realignment Commission, or BRAC; there's simply no excuse for letting parochial concerns block DOD attempts to rationalize its infrastructure to reflect the new force structure.
Read the analysis: A User's Guide to the Fiscal Year 2015 Defense Budget by Lawrence J. Korb, Max Hoffman, and Kate Blakeley
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The Shallows: What the Internet Is Doing to Our Brains
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The argument in question?
- Greater access to knowledge is not the same as greater knowledge.
- An ever-increasing plethora of facts & data is not the same as wisdom.
- Breadth of knowledge is not the same as depth of knowledge.
- Multitasking is not the same as complexity.
The studies that Carr presents are troubling, to say the least. From what has been gleaned to date, it's clear that the brain retains a certain amount of plasticity throughout life -- that is, it can be reshaped, and the way that we think can be reshaped, for good or for ill. Thus, if the brain is trained to respond to & take pleasure in the faster pace of the digital world, it is reshaped to favor that approach to experiencing the world as a whole. More, it comes to crave that experience, as the body increasingly craves more of anything it's trained to respond to pleasurably & positively. The more you use a drug, the more you need to sustain even the basic rush.
And where does that leave the mind shaped by deep reading? The mind that immerses itself in the universe of a book, rather than simply looking for a few key phrases & paragraphs? The mind that develops through slow, quiet contemplation, mulling over ideas in their entirety, and growing as a result?Read more ›
Carr argues that with the advent of reading humanity developed a different kind of neural structure. Reading which was an extension of story- telling enabled us to begin to speak to ourselves, to contemplate reality in deeper ways. The bookman mind is a deeper mind than the electronic - mind , despite MacLuhan's contrary take.
Still one might argue that we need not be the slaves of the predominant technology. It all depends upon the will, decision, determination of the individual. The horde may decide to operate in a certain way, but one has the power to shut the machine off.Read more ›
The Shallows is a thoroughly and broadly researched and beautifully written polemic which I found to represent two different things. First, it is a media analysis and culture critique. Second it is a pessimistic theory about the overall effect of web media on our thinking ability over time.
The first aspect will be a delight for those interested in the evolution of human cognition, those fascinated with media effects per se, the traditionally minded book scholars, and assorted geezers. It is a very satisfying cultural media critique very much in the spirit of Marshall Macluhan and Neil Postman even though it lacks Macluhan's showmanship or Postman's remarkable ever-present humor.Read more ›
Most Recent Customer Reviews
I have not stopped using the knowledge I gained from this book every since I read it 4years ago. It changed my life, that's for certain. Read morePublished 21 days ago by Shayen
An exhaustive and at times tedious look at the way our brains process information in the age of digital information overload. Read morePublished 22 days ago by BemisReviewsBooks
Really great book. I had to read it for my College Eng class. I will not be reselling it.Published 1 month ago by Shananagins
A lot more history than I wanted, but the main point was great.Published 1 month ago by Gatsby lover
Ever since becoming a Baha'i, I've encountered phrases and themes in Baha'u'llah's Writings such as "Reflect and Ponder", "....meditate deeply", ".... Read morePublished 1 month ago by Aaron_Zanzibari

subset: commoncrawl


text:
BERLIN (July 30, 2013)--German authorities have posted a public notice urging teen idol Justin Bieber to get in touch with them about an unpaid bill for the care of his former pet monkey Mally.
Bieber failed to produce the necessary vaccination and import papers for the monkey when he arrived for a European tour in March, and Mally became the property of the German government in May after the Canadian singer failed to claim his pet.
A spokesman for the Federal Agency for Nature Conservation says Bieber has one week to pay $1,500 for the monkey's care.
Franz Boehmer said Tuesday that if Bieber doesn't cough up the cash, officials "have ways of making him pay" the next time he enters Germany.
Bieber is already on the hook for a separate bill from Munich customs.


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OSI-Approved Open Source (41)
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CartoReso intends to facilitate enterprise computer network mapping.2 weekly downloads
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Ebound is a fun free online rpg. Come try it out today!
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Es un clon de ogame, estamos trabajando en el redesing, se buscan programadores y diseñadores.
Intermediate Payment Processor
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It is a project about open source bbs component. We apply to any environment, for example a project based struts or spring or hibernate. We are going to open this source.


text:
ODT Online
ODT /directory
About 200 people - many of them caregivers - turned out to
oppose the health board's decision to drop PSO and its
regional partner, Disabilities Resource Centre Southland.
A petition calling for the board to reconsider has gathered
more than 4000 signatures.
Starting at First Church, the marchers' procession to the
Octagon was heralded by a bagpiper.
Ms Curran told the rally she met health board managers on
Wednesday, and emerged with unanswered questions. The
decision appeared to lack transparency, she said.
Union representatives Ann Galloway (Service and Food Workers
Union) and Cee Payne (New Zealand Nurses Organisation) both
told the rally PSO was a better employer than many others
they had dealt with in the aged care sector. Workers'
advocate Mike Hanifin said PSO staff did not want to see
their organisation's work of more than 100 years disregarded
by the health board. More action was planned, he said.
PSO Family Works buddy co-ordinator Fiona Ross said her
programme faced cutbacks if her employer lost the $5.5
million annual home support contract. She believed the health
board should consider the wider effects of its decisions. The
buddy programme helped young people, which in turn made the
population healthier and less likely to need health services.
Contacted yesterday, health board chairman Joe Butterfield,
of Timaru, said he was confident the board followed the
correct process to pick its preferred providers.
Asked if he had received the PSO's letter asking to meet the
board, he said he had, but had not decided whether to grant
the request.
An Australian-owned organisation which has not provided
services outside Auckland is one of three chosen for the new
''restorative'' service, starting from March.
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Ashburton, The News - North Canterbury, Extra! schools
publication, Property
Times South Canterbury


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Hi there! I just installed Jetpack on our company site and activated the Mobile feature. Unfortunately, it's showing ALL of the pages in our site, even those that we opted not to include in our public navigation menus. (These would include pages with questionnaires for prospective clients, a client-only file upload page, etc.)
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text:
After an upgrade to
VS2010 from
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I tried
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If anyone has seen this before please give me a hint as how to fix this issue.
OS is
win7-64 SP1


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9 reviews | 3.2 out of 5
I wanted this product because it claimed to be an LED light. It was not LED. It is a regular c7 bulb for night lights. The description on the site claims that this night light uses an LED light and never needs to be changed. However, the product package does not state that the bulb is LED and gives directions on how to change the bulb. Therefore, I did not get the product that was ordered. So, be careful, the description for products on Walmart.com are not always accurate.
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Works exactly how I expected and is very handy in dealing with the infant during the night .
Quite pleased with design and quality...
Just purchased it and the sensor doesn't work.


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CNN cited the American Immigration Council's recent report ...
Get Involved
Whether you are an educator, librarian, museum curator, immigration attorney, community activist or just someone who is interested in the unique ways immigrants and immigration touch our lives, we believe you have something valuable to add to the immigration dialogue. Don't miss out on an opportunity to get involved in this pivotal topic. If you have an idea or would like to make a suggestion on how we can make immigration more accessible to your community, please email us at email@example.com
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The American Immigration Council is pleased to announce a call for submissions to the 2013 "Change in Motion" Multimedia Contest. The competition challenges today's young adults to explore the role that immigration plays in their lives and communities through video and other multimedia projects.
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WASHINGTON — The federal government may reimburse doctors for talking to Medicare patients and their families about "advance care planning," including living wills and end-of-life treatment options — potentially rekindling one of the fiercest storms in the Affordable Care Act debate.
A similar provision was in an early draft of the federal health care law, but in 2009, former Republican vice-presidential candidate Sarah Palin took to Facebook to accuse President Barack Obama of proposing "death panels" to determine who deserved life-sustaining medical care. Amid an outcry on the right, the provision was stripped from the legislation.
Now, quietly, the proposal is headed toward reconsideration — this time through a regulatory procedure rather than legislation.
The American Medical Association soon will issue recommendations on what doctors should be paid for advance care planning, or conferring with patients about the care they would want if they were incapacitated. Every year, the AMA makes reimbursement recommendations on a broad range of procedures and services to the Centers for Medicare and Medicaid Services, the federal agency that administers the Medicare program and works with state governments to administer Medicaid. CMS and private insurers don't have to follow AMA's recommendations, but they typically do.
Medicare is the country's largest health insurer. It has about 50 million beneficiaries, most of them over 65.
Geriatricians, oncologists and other medical specialists who see gravely ill patients say it's crucial to elicit a patient's wishes for treatment and other pastoral or psychological supports in a dire medical situation. Would a particular patient, for instance, want to pursue additional procedures that, while grueling, offer some slim possibility of success? Or would the patient want doctors to intervene only to alleviate pain?
If Medicare reimburses doctors for such discussions, as it pays them for examining patients and performing procedures, they are much more likely to happen.
Some private insurers, including Excellus Blue Cross Blue Shield of New York, already reimburse doctors who help patients with advance care planning. Under Medicaid, states largely determine what medical services are covered. At least two states, Oregon and Colorado, provide reimbursement for advance care planning. In Colorado, doctors can be compensated up to $80 for a 30-minute conversation to discuss advance care planning.
"We are doing this to incentivize providers to have these conversations with our clients," said Judy Zerzan, chief medical officer of the Colorado Department of Health Policy.
Phillip Rodgers, a professor at the University of Michigan Medical School and a member of the AMA group that makes compensation recommendations, said a decision by Medicare to approve reimbursement for advance care conversations would allow patients to control decision-making as their medical options narrow. Compensating doctors for such discussions would be an acknowledgement that "these conversations are a highly beneficial service that makes certain that the care we provide is the right care based on the patients' wishes," he said.
Studies show that when given a choice, patients often forgo invasive procedures at the end of life. Such procedures can be costly while doing little to extend or improve the quality of the patient's life.
But some people fear that end-of-life conversations could lead to rationing health care or withholding it entirely.
Burke Balch, director of the Powell Center for Medical Ethics at the National Right to Life Committee, said he wasn't aware of the AMA's proposal. But Balch expressed concern that the measure would result in the "denial of life-saving medical treatment."
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text:
updated 04/15/2014 AT 1:40 PM ET
•originally published 04/15/2014 AT 2:00 PM ET
He is the one who asks.
Bryan Cranston is currently on Broadway for a limited engagement as Lyndon B. Johnson in All the Way. And the Breaking Bad star certainly went "all the way" for one young fan, who requested he summon his Heisenberg-ian intensity for one very special mission: Getting him a prom date.
Stefan Montana was on hand for a performance of All the Way last week, and in the post-show fan scrum, he managed to corral Cranston long enough to request that the actor record a special message for him.
Cranston takes the smallest of moments to gather himself before looking into the camera and delivering what surely stands as the most intense, chilling prom invite ever.
The best part?
@BryanCranston she said yes!! http://t.co/inZ5h0s74S
Stefan Montana (@stefonmontana) April 11, 2014
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text:
Top Definition
The hole in the upper region of a girl's thighs when she is standing with her legs together. The T stands for thigh. Also known as the t-gap, although that term is only referred to big booty hoes.
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Zac: "Yeah, what a babe!"
dari JackDizzle&ZacBizzle Minggu, 28 Oktober 2012
Trending Now
a person who acts like a tasshole
as my friend told daily lies i said, gee, you're a real thole.
dari tasshole Senin, 10 Januari 2011


text:
User:ProveIt GT
ProveIt is a user script that makes it easy to find, edit, add, and cite references in Wikipedia articles.
You can check out our project website: http://proveit.wmflabs.org/, featuring a live working demo.
Contributors are welcome. Please post on the talk page or contact Superm401.
- 1 How to install
- 2 User guide, tutorial, help
- 3 Features and benefits
- 3.1 Easily create, edit, and find references
- 3.2 Easily install, update, and use ProveIt
- 4 Userbox
- 5 Team and credits
- 6 External links
How to install[edit]
English Wikipedia[edit]
Note: If you've already installed ProveIt the old way (editing your), delete any ProveIt-related code first.
- Log in to Wikipedia. If you don't have an account, you'll have to create one.
- Go to your Gadget preferences page.
- Find ProveIt under the "Editing" heading and check the box beside it.
- Click Save at the bottom of the page.
That's it! You may start using ProveIt immediately. You can practice by adding a reference to sample text at the Sandbox or go to any other Wikipedia article and click the Edit tab. Click "References" or "Add a Reference" to maximize ProveIt.
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text:
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Dior is pleased to offer complimentary shipping for orders of $50 or more. Simply create an account and click yes to become a Dior Diva and complimentary ground shipping will be automatically added to your order.
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A unique and contrasting signature, with a powerful enchanting trail. Fresh Sicilian Mandarin notes, and the surprising combination of masculine Wood and Leather with an unprecedented Violet accord.
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All Mediterranean countries grow mandarin trees, but the best mandarins are produced in Sicily. The different colors of mandarin, yellow, green and red, correspond to the different stages of ripeness. Essence of mandarin is a citrus note, offering fragrances a fresh and fruity accent. Mandarin is the exotic top note of Fahrenheit.
The leaves of the violet produce a unique and powerful fragrance with green, vegetable and ever so slightly flowery notes. The sensual violet is a surprising heart note in Fahrenheit.
The leather note was originally created to imitate the smell of the Russian leather used to make hussars' boots. Their soft leather was tanned using birch bark. Perfumers recreated these burnt, smoky, birch, styrax and cade notes delivering an exotic, enchanting effect. It features as a base note in Fahrenheit.


text:
I have a Windows 7 64-bit machine (Thinkpad). I updated Windows yesterday and after a restart, explorer crashes instantly. I've tried many of the hints given on forums like file system check etc. but it hasn't helped. Also tried removing the updates but unfortunately, it didn't help.
I've tried both sfc /scannow (system file check) & clean start up but it didn't help. What worked for me was this :
What specifically did you update? You ran Microsoft updates?
Boot into safe mode and see if it still happens. While there run
at a command prompt to make sure all your Windows files are not corrupt. You can also run msconfig>services>Hide all Microsoft services and disable all non-Microsoft services, then go to msconfig>startup and disable everything there. Boot back into normal mode with all those disabled. If it runs, reenable them all until the culprit exposes itself, and then repair or update that program.
If all this fails, and it did start happening after doing a Microsoft update, call Microsoft for free hot-fix support: (800) 936-4900.


text:
regarding a momentum stock BBEP 1 commentFeb 2, 2010 10:30 AM
Their current P/E is 4.19 but they do not have enough growth to even figure a PEG. P/S is a bit high to be a value sign at 1.21 (I look for <1) but their Quick Ratio is good at 1.80 (I look for >=1). When you look at the cash flow ratios - something wonderful shows up:
1)Price/Free Cash Flow = 7.31 (<=15 is great)
2)The Operational Cash Flow/Share = $4.16
3)so Price/CFO = 3.35 (<=5 is great)
The combination of both of these Ratios is rare and usually show a stock worth backing up the truck for. I have to agree with Joe Ponzio - this stock is an excellent choice. I would use it in my trading portfolio as their dividend record does not qualify them as a core stock - but it is a GREAT trade stock especially when you take the P/B being less than 0.66 into consideration. This means that a 50% minimum gain over the next 2 years is very possible according to Ben Graham's researchBack To Chris Uhlir's Instablog HomePage »
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.Comments (1)Track new commentsFull index of posts »
Moore's Law Applied To Solar Energy http://seekingalpha.com/p/23u0z Dec 9, 2014
http://bit.ly/13DprWs Oct 14, 2014
Latest Comments
- Chris Uhlir on Security is water, food, shelter.... From www.tallahassee.com/ar......In 2005, resid...
- Tom Au, CFA on Deflation vs. hyperinflation People like Obama want to give us the (socialis...
- Chris Uhlir on regarding a momentum stock BBEP This is a good set of ratios to use in stock pi...
Most Commented
- regarding a momentum stock BBEP ( Comments)
- Deflation vs. hyperinflation ( Comments)
- Security is water, food, shelter.... ( Comments)
- Moore's Law Applied To Solar Energy http://seekingalpha.com/p/23u0z


text:
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Success! Thanks for repurchasing.{{/if}} {{else}} {{#if Expired}}
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{{#if HasMultiPack}} You have {{MultiPackCount}} top spot(s) left. Now loading you into the search listings... {{else}} You have used all top spots. Now loading you into the search listings... {{/if}}{{else}}
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{{Current}} just saw you!{{/if}} {{#if LastTopSpotPurchaseIsMulti }} {{#if HasAnyTopSpot}}
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{{Current}} see you now!{{else}} {{/if}} {{/if}}
49 year old woman | Bothell, WA, United States | Seeking men 40-50 within 25 miles
Music, laughter and fun......
I love music! I like all kinds of music and I like finding new music -- or music that is new to me. Family and friends are the most important thing to me -- especially spending as much time as I can with my daughter. Other interests of mine include travel, being on or near the water, reading, cooking/entertaining, great restaurants and football in the fall (Huskies and Seahawks). My friends describe me as fun, social, smart and loyal. I consider myself to be spiritual, intelligent, affectionate and loyal. I appreciate spending time with someone who enjoys some of the same things that I do but who also has his own interests that he is willing to share them with me (teach me something new?). I enjoy people who are honest and respectful of others and someone who can enjoy life to the fullest. Life is too short -- so let's just enjoy and appreciate every minute of it!
Book club , Coffee and conversation , Business networking , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Walking / Hiking, Yoga
I exercise 3-4 times per week.
I have Cats
I like Dogs, Fish
My daughter named our cat -- his name is Ken. He acts more like a dog than a normal cat.
Some other viewpoint
I love the water so any beach is great! I loved traveling in Portugal and France, but I would really like to visit Scotland and Greece. Mexico is always a fun, quick trip to the sunshine!
University of Washington, Seattle, WA
I love music and I enjoy going to live shows at smaller venues. A few of my favorite TV shows right now.... Royal Pains, The Newsroom, SNL, Jimmy Fallon and anything on History or H2!
I enjoy music, reading, cooking, boating, traveling and spending time with my daughter as well as other family and friends.
My favorite genre is historical fiction but I am in a book club and we just read The Little Stranger... on to the next book now!
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|5'8" (172cms) to 6'6" (198cms)
|Body type:
|About average
|Slender, About average, Athletic and toned, A few extra pounds
|No preference
|Dark brown
|No preference
|No Way
|No Way, Cigar aficionado
|Social Drinker
|Social Drinker
|Sales / Marketing
|No preference
I work in the advertising industry in Seattle.
|I'll tell you later
|$75,001 to $100,000, $100,001 to $150,000, $150,001+
|No preference
|Have kids:
|Yes, and they live at home (1)
|No preference
|Wants kids:
|Not sure
|No, but it's OK if my partner has kids
|White / Caucasian
|No preference
I was born in Seattle and have lived in the greater Seattle area my entire life.
|Spiritual but not religious
|No preference
|No preference
|Bachelors degree
|No preference
I graduated from the University of WA, School of Communications/Advertising -- go Huskies!


text:
Washington University in St. Louis has embarked on several initiatives in India, working collaboratively with its primary partners through the McDonnell International Scholars Academy. The partner universities are Indian Institute of Technology Bombay; Tata Institute of Social Science; and Jawaharlal Nehru University. There are 150 faculty at Washington University connected to India or have projects underway.
The Gateway of India is a monument built during the British Raj in Mumbai (formerly Bombay), India.It is located on the waterfront in the Apollo Bunder area, South Mumbai and overlooks the Arabian Sea.
Washington University in St. Louis has embarked on several initiatives in India, working collaboratively with its primary partners through the McDonnell International Scholars Academy.
Pictured left to right: Director Devang Khakhar, Professor Pratim Biswas, Minister of Water, Uma Bharati, Chancellor Wrigton, and Professor Ravi Sinha
A group of 53 faculty got together to discuss India initatives underway at Washington University. There are about 157 faculty connected to India related activities
The Indian Ambassador to the U.S.A., Ms. Nirupama Rao after her presentation with
leaders at the Corporate Conclave held at Washington University in St. Louis.
The U.S. Department of Energy has selected a consortia led by NREL
with Washington University as a partner to create a $25 million Solar Energy
U.S.-India Joint Clean Energy Research and Development Center.
Highlights of Activities
More than 25 collaborative,
trans-disciplinary research
projects in Clean Energy and Environment.
Major funded initiatives in Energy,
Environment and Development.
Educational Programs (Short Courses, Joint Degree, Certificate Program, Student Exchanges).
Flagship program is joint EMBA degree
program with IIT Bombay
About 150 Washington University faculty
with India connections. Network of Faculty (more than 30 with
collaborative projects in India)
Network of PhD and UG Students
Mr. Ram Madhav is the National General Secretary of Bharatiya Janata
Party and Director of India Foundation, In his role as the National
General Secretary, he works closely with Prime Minister Narendra Modi. Click
here for more information


text:
I work with entrepreneurs—like you—that are building a business and life you're passionate about. You're looking for a kick-ass business coach who can help you expand your rockin' business empire.
The question is: HOW?
:: how do you double your business and reach?
:: which offerings are the best to convert them into clients?
:: And which systems should you implement to DO all of that?
Bottom line? I've got you.
Because over the past 10 years, I've helped thousands of entrepreneurs figure out everything they need to run a successful business using a killer combination of web, marketing, systems and sales strategies.
I'd love to help you do the same. You in?
Together, we'll create a roadmap for your business that'll help you STOP wasting time, do what you love, and make more money in the process.
Ready to go all in? I can help you do just that.
I only work one on one because this is how my clients get results they want.
Here's how we can work together. 3 Options.


text:
SDCC: "Batman: The Killing Joke" Cast & Crew Debuts Film at Comic-Con International
Conventions | Comic-Con International is seeking a new sponsor for Artists' Alley after DeviantArt, the sponsor of the area for the past two years, withdrew support. In a letter sent Wednesday to exhibitors, organizers said they are seeking a new sponsor and remain committed to Artists' Alley. Heidi MacDonald provides context, noting that the development comes amid ongoing fears about the future of Artists' Alley, which occupies valuable floor space in an exhibition hall starving for more. [The Beat]
Political cartoons | Michael Cavna has issued an open for cartoonists to draw cartoons in support of imprisoned Iranian artist Atena Farghadani, and tweet them with the hashtag #Draw4Atena. Robert Rusell, executive director of Cartoonist Rights Network International, has written an open letter to the leaders of Iran asking them to intervene. [Comic Riffs]
Over the past few weeks, thousands — probably tens of thousands — of graduates of received diplomas in a broad range of studies, but it's safe to say that none of them is as cool as the ones handed out by the Center for Cartoon Studies in White River Junction, Vermont.
Each year the school commissions a cartoonist to create the diploma for that graduating class. This year, it was Jason (I Killed Adolf Hitler, The Last Musketeer). You see those from previous years, from the likes of Ed Koren, Jim Rugg, R. Sikoryak, Eleanor Davis, Michael Kupperman and Ivan Brunetti, on the CCS Flickr page.
Publishing | Variety speaks with Madrigall President Antoine Gallimard about how the French publishing giant and its holdings (Gallimard, Casterman, Flammarion and Futuropolis, among them) handle the film rights to their many graphic novels, and the popularity of comics as source material: "I think that the French publishing and film industries feed on, complement, and ultimately do help each other. The number of films adapted from books that are produced every year in France is eloquent testimony to this." Noting that, "In recent years, there's a real feeding-frenzy for graphic novels, comic books," Gaillimard says, "Comedy, in all its variants, is the most popular of adapted materials." [Variety]
Legal | An Algerian judge has made a preliminary recommendation of 18 months' imprisonment for cartoonist Djamel Ghanem for drawing a cartoon, which was never published, that government officials deemed offensive. In an odd twist, Ghanem was sued by his own newspaper, La Voix de l'Oranie, which tends to favor the current administration, and as a result, he has been blackballed by the Algerian media. The cartoon is critical of President Abdelaziz Bouteflika's bid for a fourth term but doesn't even depict the president — it shows two people in conversation, comparing the fourth term to baby diapers — Ghanem said the point was that Algerians were treated like children. Pressed by the district attorney to admit the cartoon was insulting to the Bouteflika, Ghanem insisted that wasn't his intention. [Global Voices Online]
Edward Koren, well known for his cartoons, covers and illustrations for The New Yorker, will be honored Feb. 27 as Vermont's second cartoonist laureate. Burlington resident James Kochalka was the first.
A New York City native, Koren lives with his family in Brookfield, Vermont, where he has served as a volunteer firefighter for 24 years. Beyond his more than 1,000 cartoons for The New Yorker, he has contributed to such publications as The New York Times, Vanity Fair, GQ, The Nation and Esquire. Koren has also illustrated numerous books.
"The great imaginative artists, comic or seriocomic (what other kinds are there?), are great at least in part because they create a world: Baldwin's Harlem, Faulkner's hamlet, Chekhov's dachas," The New Yorker Editor David Remnick said in a statement. "Ed Koren not only created a world — the Koren worlds are both urban and Vermontian, but all Koren — he also created creatures, part human, part fantastical, to represent and give voice to all of our anxieties, joys, and craziness. Long live Ed Koren, his world and his creatures!"
Following his recognition Feb. 27 on the floor of the State House, Koren will begin his three-year term with a public lecture at The Center for Cartoon Studies in White River Junction. Vermont is the only state that appoints a cartoonist laureate.


text:
The aircraft carrier USS Lexington (CV-16) was launched in September 1942. The Essex Class carrier could carry up to 120 folded wing aircraft, sail up to 33 knots and carried a crew of 2,600.
Aboard the ship, known usually as "The Lady Lex," was Walter Trahan, who I interviewed during one of his frequent family visits to Hot Springs Village.
He grew up in Rhode Island, played tennis and baseball in school and still remembers Dec. 7, 1941.
"I was sitting in my living room with my brother, mother and father playing cards," Trahan recalls. They were all simply amazed at the news. He feels the United States had to have known an attack was coming somewhere. "We should have been prepared," said Trahan.
He decided to join the Navy, but first, in January 1942, went to radio school to have a skill under his belt. Thereafter he applied to the Navy which turned him down.
"They didn't like a 118-pound, 6-foot-2-inch boy," said Trahan of his stature at the time.
He later interviewed with a recruiter who asked why he wasn't in the service. Trahan explained what happened when he tried. Right then and there the recruiter said he'd sign him up.
In September 1942 in Providence, R.I. he formally enlisted and was sent to Newport for processing and shots. From there he was sent to radio school in Boston, Mass.
He finished the school in December after learning how to quickly copy Morse code. He then reported to the USS Lexington whose name was changed from USS Cabot because the Lexington CV-2 had been sunk on May 8 in the Battle of the Coral Sea.
Trahan joined the ship in dry-dock in Boston. Once aboard the huge vessel Trahan said he got lost below deck, ending up "in officers country" as he put it. He eventually made his way to the mess hall to eat.
The ship left Boston for a shakedown cruise and got caught in a rough storm. Trahan and many others got seasick. "It was tough. I was one sick puppy," he noted of his maiden voyage.
Next the Lex went to Trinidad to pick up F4F aircraft and train pilots for carrier landings. After resupply the ship sailed through the Panama Canal where he got a short liberty. From there they traveled to Pearl Harbor where Trahan saw still-remaining battle damage from the Dec. 7 Japanese attack.
After a short layover they joined the fleet and sailed to Kwajalein in December where they participated in attacks. Trahan's job put him in the radio shack in the ship's island tower.
He was there when the Lexington was torpedoed, killing nine crewmen. "All of a sudden the ship was shaking like mad," said Trahan of the attack that took out the ship's steering. Two destroyers stayed with them as they made their way back to Pearl for repairs. From there the Lex sailed on to Bremerton, Wash., arriving in late December for full repairs.
Trahan took a 21-day leave, but didn't call home to let family know he was coming. He got to his house and no one was there. So he went to the neighbor's house and learned his parents were at his grandparents' house.
His mother asked where he was calling from and he said "home." "I'll be right there," said his excited mom.
Following the leave Trahan returned to the ship and headed back to Hawaii, arriving in late February. She joined a Task Force and helped cover several Pacific island invasions including Truk on April 28, Ulithi in September and later Luzon in the Philippines. On Nov. 5 she was hit by a kamikaze at the back end of the ship's island, just 30 to 40 feet away from where Trahan was working.
Tokyo reported the Lexington sank, but they were in error, Lexington had made it back to Ulithi by Nov. 9. This was the third time Japanese sources had reported the ship sank, so the ship took on another nickname – The Blue Ghost.
In February 1945 the repaired ship hit a huge typhoon in which some destroyers tipped over and sank. The typhoon is written about in the book "Halsey's Typhoon," with some saying it was the only blight on Adm. Halsey's career when he sailed a large Task force into the storm.
The ship survived the ordeal and made many stops at Pacific islands, places like Mog Mog, for supplies and would then return to the fighting. "You got to a point where you say am I ever going to see something besides ocean. We were pretty much at sea almost all the time," said Trahan.
In August the United States dropped the atomic bombs. "We were not too far from Tokyo. We had entered that area to bomb the Tokyo area. We didn't do so well because the weather was so bad," Trahan remembered.
Then the word came – the Japanese would surrender, the war would soon be over. Of that moment Trahan said they had launched planes for an attack, but called them back to the ship. There was no sense of anyone dying unnecessarily.
Over the loudspeaker the Captain told his crew the fighting was over. The Blue Ghost then pulled into Tokyo Harbor, near the USS Missouri where the formal Japanese surrender would be signed on Sept. 2, 1945. From a distance Trahan observed.
He also spent time on shore, in Tokyo, and wondering when would he be able to get back home.
Still working on code, every morning Trahan put together information from the press. "I copied the stories from Associated Press," Trahan said.
All the men were anxious to return home, wondering how many points they had accumulated. It took 85, and Trahan was short of that amount so he remained for several more months. Finally on Dec. 15, 1946, he was back on American soil. From San Diego he went to Boston where he was discharged on Jan. 1, 1946.
As a civilian Trahan spent 50 years in radio and television in Rhode Island working in maintenance, editing, technical support and "a little bit of everything," he said. Trahan even helped build radio stations. He retired in September 1991.
Looking back on the war and his experiences, he reflected on the impact it had on him. "It set my lifestyle for the rest of my life. That's why I decided to get into radio and television," said Trahan. "I'm proud of my service and would do it again if I was asked."
Trahan has one child, Larry.


text:
Clarins Exfoliating Body Scrub
27 reviews
77% would repurchase
Package Quality: 4.0
Price: $$$
Package Quality: 4.0
Price: $$$
on 6/4/2015 12:28:00 AM
Age: 19-24
Skin: Oily, Fair, Not Sure
Hair: Red, Other, Other
Eyes: Green
I'm mega on the fence about this one, I sort of feel like it's just grit in a tube? I've had two tubes as a GWP from debenhams and I think I'd have been rather peed off if I had purchased it. The grit is nice and abrasive but it's a really thick cream so you have to use HUGE handfuls to get anywhere with it, and it doesn't seem to have any scent at all? I've given it 3 stars simply because it does what it says and leaves my skin smooth, but then again so would a handful of sugar for a fraction of the price?
on 1/7/2015 9:13:00 AM
Age: 19-24
Skin: Dry, Fair-Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Blue
I like this body scrub as you can feel it working (I hate really gentle exfoliators that do absolutely nothing!) and it leaves skin feeling lovely and smooth. The perfect consistency and a subtle, non-offending scent.
However I think it's way overpriced for just a 'nice' body scrub. You can get body scrub from Soap and Glory for much less which is equally as good. I definitely couldn't justify buying this regularly.
To Read all 27 Reviews, Login or Join
on 3/10/2012 3:36:00 PM
Age: 30-35
Skin: Acne-prone, Fair, Not Sure
Hair: Black, Other, Other
Eyes: Black
An extremely effective yet non-abrasive product, which gently renews skin's surface without any strong scent.
Notably, unlike some of its price-point rivals, will not (i) dry out skin or (ii) leave behind any unwelcome residue to block pores.
on 5/23/2009 11:31:00 PM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
Best body scrub I've used so far, but a bit more than what I'd spend for a body scrub normally.
on 9/7/2007 12:39:00 PM
Age: 30-35
Skin: Acne-prone, Fair, Cool
Hair: Brown, Straight, Fine
Eyes: Blue
I received this scrub in a swap and like it. It isn't as exfoliating as some scrubs, because the granules are fairly fine, but it feels good and isn't as messy as the scrubs that are large granules floating in oil. I found the smell to be kind of masculine, although I don't mind it. I don't think I would buy it because it is fairly expensive and I am coming to the conclusion that it is just as effective and so much cheaper to use body wash with synthetic scrubby gloves. If you love Clarins, go for it, but otherwise, I don't think it is anything really special.
on 4/2/2007 2:47:00 AM
Age: 36-43
Skin: Combination, Fair, Not Sure
Hair: Other, Other, Other
Eyes: Green
This is my favorite body scrub. I like it for several reasons. It comes in a tube instead of a tub, which is much easier to open and use in the shower. I also like that it doesn't leave an oily film on my skin or in my tub like many of the body scrubs on the market today. I don't have to worry about my kids getting into the tub and slipping after using this. The orange creamsicle smell isn't overpowering. And I like the results it gives me. It has really helped with those little bumps on the backs of my arms and thighs. This is a great product and exactly what I was looking for in a body scrub. Thank you to Clarins. I just wish it weren't so expensive. $33 at Sephora.
on 11/12/2006 11:25:00 PM
Age: 30-35
Skin: Combination, Other, Not Sure
Hair: Black, Other, Other
Eyes: Black
One of my favourite scrub, i like the small granules. The smell is ok, not fantastic. Price is kinda exp, i only buy it when robinson counter having 20% sale (Singapore).
on 8/19/2006 10:19:00 AM
Age: 19-24
Skin: Combination, Fair-Medium, Warm
Hair: Brown, Straight, Fine
Eyes: Blue
I really loved this scrub, left my skin silky soft and evened out my fake tan beautifully...I used to only use d/s body scrubs like st ives one but its only when ive used a high end one i can see the difference. Theres only 1 thing that puts me off re purchasing this its the smell- its really strong. but the quality is so superb that i think i will re purchase after all
on 7/31/2006 10:07:00 AM
Age: 30-35
Skin: Normal, Dark, Not Sure
Hair: Brown, Other, Other
Eyes: Black
Excellent scrub if you're after a gentle exfoliator. The scrub particles are quite smooth and all the same size which (according to Clarins at least) are better than natural particles like walnut shells which can scratch the skin surface.
If you find this too gentle, try using it with a loofah with it, especially for legs and rough patches. I had a body treatment Institute Clarins and this is what the therapist did, and it made my skin baby smooth. I don't mind the scent which I find pretty neutral. The only thing I don't like is that this leaves a moisturising film on skin, which can be sticky. continued >>
on 7/5/2006 4:17:00 PM
Age: 36-43
Skin: Oily, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I received a tube of this as a GWP, but would never buy it on its own considering the price. The scrub comes in a creamy base with smaller than usual granules. My complaint with it is that you have to use a LOT of product to get your whole body done because of the size of the grains and the way the product is dispersed in a cream. Seems like for the price I could get several cheaper scrubs that would last much longer. The scent is also rather odd as well (chemical smell). It didn't seem to exfoliate my skin as well as some other products I've tried.
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Supreme Court to decide on convict's right to test DNA
Published: Monday, March 2, 2009 at 8:28 a.m.
Last Modified: Monday, March 2, 2009 at 8:28 a.m.
WASHINGTON (AP) William Osborne, convicted in a brutal attack on a prostitute in Alaska 16 years ago, says a blue condom holds evidence of his innocence or confirmation of his guilt.
Either way, he says, the Constitution gives him the right to test the genetic evidence to find out.
The Supreme Court was to hear arguments Monday on Osborne's case and announcing whether it has accepted any new appeals.
More than 230 people have been exonerated based on DNA tests performed years after their convictions, according to the Innocence Project, a legal group that has sought genetic testing on behalf of hundreds of prison inmates and led the charge to free those who were wrongly convicted.
In many cases, eyewitnesses picked out the wrong man, often with the victim of one race incorrectly identifying someone of a different color. Among the exonerated were people who confessed to crimes, even though they were innocent.
The woman in Alaska was raped, beaten with an ax handle, shot in the head and left for dead in a snow bank near the Anchorage International Airport. The condom was found nearby.
The woman, who is white, identified Osborne, who is black, as one of her attackers. Another man also convicted in the attack has repeatedly incriminated him. Osborne himself admitted his guilt under oath to the parole board in 2004.
Osborne's lawyer passed up advanced DNA testing at the time of his trial, fearing it could conclusively link him to the crime.
The results of the case could be limited. Forty-four states and the federal government have laws that give convicts access to DNA testing. And more states are moving in that direction, the Innocence Project says.
Alaska has no DNA testing law, but its Court of Appeals has given people a path to follow to gain access to the evidence. It ruled Osborne did not meet the standards it set out.
The benefit to Osborne himself also is limited. He is awaiting sentencing for his role in a home invasion that occurred a few months after his parole in 2007.
If he wins his court case and the DNA in the condom is not his, he could have six years shaved off an expected 15-year prison term.
A decision is expected in spring.
The case is District Attorney's Office v. Osborne, 08-6.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
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I have a problem with twentyten (1.5) When I hover over the Home Page menu item I get an unnecessary (and unwanted) pop up appear which says 'Home'. See here:-
Can anyone tell me where to go and what to edit to get rid of this little annoyance?
I am learning css slowly! I am guessing that the problem lies in the twentyten style.css ?


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Five of our favorite DMX moments
If you're taking part in the Zombie Pub Crawl this weekend, get read to stop, drop, shut 'em down, and open up shop as DMX is rolling into town to get at you, dog!
X is gon' give it to ya at 9 p.m. Saturday at Midway Stadium, AKA Zombie Island. Unless you're slippin', you know the combination of zombies, ballparks and X's raw energy are not to be missed. In our excitement, we decided to take a look at five of our favorite recent DMX moments.
See Also:
Zombie Pub Crawl 2012 music lineup unveiled
5. DMX Learns Lil B's Album is Going to be Named I'm Gay
What's great about DMX's reaction here, is how you can read his entire thought process just by watching him. From shock, to disgust, to quizzical to ultimate acceptance, X lays it all out and gives us a look at how his Dark Mind X works.
4. When X Met Google
DMX's time on a major label ranks among the most prolific of any rap artist in the corporate realm. Along with two albums in his first year, his annual releases became an anticipated rap event. As a result, music's always kept him busy. Too busy, in fact, to learn how to Google himself. In this clip, X confronts his fears and enters the 21st century as only he can.
3. Dark Critic X
What made X's debut It's Dark and Hell is Hot stand out was its visceral rawness during hip-hop's shiny suit era. The uncut, unfiltered qualities of DMX have always been a big part of his charm, so when asked to give his thoughts on today's hottest hip-hop stars, honesty ensues.
2. Dark Mom X
We've always enjoyed X's acting endeavors on the big and small screens, but our favorite has to be this sketch from "Mad TV" where X (playing himself) confides to his mother (played by Aries Spears) about the pain in his heart. Spears' impressions of rap artists have always been uncanny, and this sketch plays to the pair's strengths perfectly.
1. Reading Rainbow Gets Ruff
While X himself had no involvement in its creation, we'd be remiss not to mention this wonderful clip. Bringing tears of laughter to our eyes, the geniuses at A Good Town, enhanced a cherished song from our childhoods by matching it up perfectly with some of X's greatest ad libs. It's further proof of the joys that public television and DMX can inspire.
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Comment Null Island, Pacific style (Score 1) 91
A long time ago I was working with GPS applications and their internal representation of longitude meant our Null Island was in the middle of the Pacific Ocean, 0 north, 180 west.
We figured out the conventions of the mapping application we were using (no Google Maps yet, and the documentation was vague) by trial and error. Our first attempts to plot GPS fixes from a drive along a local freeway showed a blank area with no freeway, nor much of anything else. We found that we were drawing a map centred on 49 degrees north (correct) but 123 degrees east, out in the middle of nowhere near the border between China, Mongolia and Russia. Nearest town Harbin, China...


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Reserve your spot in our After–School Program (ASP) by submitting your registration form and $39 fee to the main office. These forms are available in the main office or by clicking here. The program serves students in grades K-8 and offers academic support, structured physical activities, games, crafts, technology enrichment, and a Leadership Training Program for older students. ASP is available on every early release day except the last day of school. Part-time care is also available.
See forms below for further info:
15-16 ASP Tuition/Fee Schedule
Contact Information:
Vicky Wilson, After-School Program Director
(919) 644-6272, ext. 111


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Summerfest headliners Pretty Lights, Phil Vassar returning to Milwaukee
Pretty Lights was one of the core reasons Summerfest was so incredibly packed Saturday.
Clearly there's huge demand for the hip hop-influenced electronic music artist--and fulfilling that demand, Pretty Lights is coming back to Milwaukee, headlining the Rave Nov. 14, the venue has announced. »Read Full Article
'Billy Jack' star Tom Laughlin dies at 82
Tom Laughlin, the maverick actor and filmmaker best known for the "Billy Jack" films, has died, the Los Angeles Times reported Sunday. He was 82.
Laughlin, who played football at Milwaukee's Washington High School and attended Marquette University and the University of Wisconsin-Madison, died Thursday in Thousand Oaks, Calif., his family announced Sunday. »Read Full Article(7)
Rhode sisters bring Christmas memories to Sunset Playhouse
A cozy set, dressed in greens and reds as the sort of living room in which Christmas is celebrated throughout America.
Candid, often dorky photos of a 1980s childhood, with all the bad fashion choices this implies. »Read Full Article
Milwaukee Ballet balances playfulness, theatrics in 'The Nutcracker'
One would think that reviewing the same production of "The Nutcracker" several years in a row would start to get a bit tedious.
One would be wrong. »Read Full Article


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We have just purchased the pro pack for connections and we are wanting to import a csv file of all the staff contacts. There are some fields in the CSV file that are nothing like the ones you can select in connections to map to.
Please can you tell me if there is a way to change the field names in connections? I found a post by googling that said change the names in the class.options.php file. I did change one field name in this php file but nothing happened.
Please help - thanks


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FDA Approves Simponi to Treat Ulcerative Colitis »
"The U.S. Food and Drug Administration today approved a new use for Simponi (golimumab) injection to treat adults with moderate to severe ulcerative colitis.
Simponi works by blocking tumor necrosis factor (TNF), which plays an important"...
Read the FDA Approves Simponi to Treat Ulcerative Colitis article »
Mechanism Of Action
The mechanism of action of mesalamine is not fully understood, but appears to have a topical anti-inflammatory effect on the colonic epithelial cells. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
Mesalamine has the potential to inhibit the activation of nuclear factor kappa B (NFκB) and consequently the production of key pro-inflammatory cytokines. It has been proposed that reduced expression of PPAR≈ nuclear receptors (≈-form of peroxisome proliferator-activated receptors) may be implicated in ulcerative colitis. There is evidence that mesalamine produces pharmacodynamic effects through direct activation of PPAR≈ receptors in the colonic/rectal epithelium.
The pharmacodynamic actions of mesalamine occur in the colonic/rectal mucosae local to the delivery of drug from LIALDA into the lumen. There is information suggesting that severity of colonic inflammation in ulcerative colitis patients treated with mesalamine is inversely correlated with mucosal concentrations of mesalamine. Plasma concentrations representing systemically absorbed mesalamine are not believed to contribute extensively to efficacy.
The total absorption of mesalamine from LIALDA 2.4 g or 4.8 g given once daily for 14 days to healthy volunteers was found to be approximately 21-22% of the administered dose.
Gamma-scintigraphy studies have shown that a single dose of LIALDA 1.2 g (one tablet) passed intact through the upper gastrointestinal tract of fasted healthy volunteers. Scintigraphic images showed a trail of radio-labeled tracer in the colon, suggesting that mesalamine had distributed through this region of the gastrointestinal tract.
In a single dose study, LIALDA 1.2 g, 2.4 g and 4.8 g were administered in the fasted state to healthy subjects. Plasma concentrations of mesalamine were detectable after 2 hours and reached a maximum by 9-12 hours on average for the doses studied. The pharmacokinetic parameters are highly variable among subjects (Table 3). Mesalamine systemic exposure in terms of area under the plasma concentration-time curve (AUC) was slightly more than dose proportional between 1.2 g and 4.8 g LIALDA. Maximum plasma concentrations (Cmax) of mesalamine increased approximately dose proportionately between 1.2 g and 2.4 g and sub-proportionately between 2.4 g and 4.8 g LIALDA, with the dose normalized value at 4.8 g representing, on average, 74% of that at 2.4 g based on geometric means.
Table 3: Mean (SD) PK Parameters for Mesalamine
Following Single Dose Administration of LIALDA Under Fasting Conditions
|Parameter1 of Mesalamine
|LIALDA 1.2 g
|LIALDA 2.4 g
|LIALDA 4.8 g
|AUC0-t (ng•h/mL)
|20538 (12980)
|41434 (26640)
|AUCo-∞ (ng.h/mL)
|9578• (5214)
|21084 (13185)
|44775# (30302)
|Cmax (ng/mL)
|857 (638)
|1595 (1484)
|2154 (1140)
|Tmax* (h)
|9.0** (4.0-32.1)
|12.0 (4.0-34.1)
|12.0 (4.0-34.0)
|Tlag* (h)
|2.0** (0-8.0)
|2.0 (1.0-4.0)
|2.0 (1.0-4.0)
|T½(h) (Terminal Phase)
|8.56• (6.38)
|7.05§ (5.54)
|7.25# (8.32)
|1Arithmetic mean of parameter values are presented except
for Tmax and Tlag.
*Median (min, max); +N=43, •N=27, §N=33, #N=36, **N=46
Administration of a single dose of LIALDA 4.8 g with a high fat meal resulted in further delay in absorption, and plasma concentrations of mesalamine were detectable 4 hours following dosing. However, a high fat meal increased systemic exposure of mesalamine (mean Cmax: 91%; mean AUC: 16%) compared to results in the fasted state. LIALDA was administered with food in the controlled clinical trials that supported its approval.
In a single and multiple dose pharmacokinetic study of LIALDA, 2.4 g or 4.8 g was administered once daily with standard meals to 28 healthy volunteers per dose group. Plasma concentrations of mesalamine were detectable after 4 hours and were maximal by 8 hours after the single dose. Steady state was achieved generally by 2 days after dosing. Mean AUC at steady state was only modestly greater (1.1-to 1.4-fold) than predictable from single dose pharmacokinetics.
In a single dose pharmacokinetic study of LIALDA, 4.8 g was administered in the fasted state to 71 healthy male and female volunteers (28 young (18-35yrs); 28 elderly (65-75yrs); 15 elderly ( > 75yrs)). Increased age resulted in increased systemic exposure (approximately 2-fold in Cmax), to mesalamine and its metabolite N-acetyl-5-aminosalicylic acid. Increased age resulted in a slower apparent elimination of mesalamine, though there was high between-subject variability. Systemic exposures in individual subjects were inversely correlated with renal function as assessed by estimated creatinine clearance.
Table 4: Mean (SD) PK Parameters for Mesalamine Following
Single Dose Administration of LIALDA 4.8 g under Fasting Conditions to Young
and Elderly Subjects
|Parameter of 5-ASA
|Young Subjects (18-35 yrs)
|Elderly Subjects (65-75 yrs)
|Elderly Subjects ( > 75 yrs)
|AUC0-t (ng•h/mL)
|51570 (23870)
|73001 (42608)
|65820 (25283)
|AUCo-∞ (ng•h/mL)
|58057b (22429)
|89612c (40596)
|63067d (22531)
|Cmax (ng/mL)
|2243 (1410)
|4999 (4381)
|4832 (4383)
|tmaxa (h)
|22.0 (5.98 - 48.0)
|12.5 (4.00 - 36.0)
|16.0 (4.00 - 26.0)
|tlaga (h)
|2.00 (1.00 - 6.00)
|2.00 (1.00 - 4.00)
|2.00 (2.00 - 4.00)
|t½ (h), terminal phase
|5.68b (2.83)
|9.68c (7.47)
|8.67d (5.84)
|Renal clearance (L/h)
|2.05 (1.33)
|2.04 (1.16)
|2.13 (1.20)
|Arithmetic mean (SD) data are
presented, N = Number of subjects
aMedian (min -max),
Mesalamine is approximately 43% bound to plasma proteins at the concentration of 2.5 μg/mL.
The only major metabolite of mesalamine (5-aminosalicylic acid) is N-acetyl-5-aminosalicylic acid. Its formation is brought about by N-acetyltransferase (NAT) activity in the liver and intestinal mucosa cells, principally by NAT-1.
Elimination of mesalamine is mainly via the renal route following metabolism to N-acetyl-5aminosalicylic acid (acetylation). However, there is also limited excretion of the parent drug in urine. Of the approximately 21-22% of the dose absorbed, less than 8% of the dose was excreted unchanged in the urine after 24 hours, compared with greater than 13% for N-acetyl-5-aminosalicylic acid. The apparent terminal half-lives for mesalamine and its major metabolite after administration of LIALDA 2.4 g and 4.8 g were, on average, 7-9 hours and 8-12 hours, respectively.
Drug Interactions
The potential effect of Lialda (4.8 g given once daily) on the pharmacokinetics of four commonly used antibiotics were evaluated in healthy subjects. The four antibiotics studied and their dosing regimens were as follows: amoxicillin (single 500 mg dose), ciprofloxacin XR (single 500 mg dose), metronidazole (750 mg twice daily for 3.5 days), and sulfamethoxazole/trimethoprim (800 mg/160 mg twice daily for 3.5 days). Coadministration of Lialda did not result in clinically significant changes in the pharmacokinetics of any of the four antibiotics. The change in Cmax and AUC of amoxicillin, ciprofloxacin and metronidazole when they were co-administered with Lialda were all ≤ 3%. There was an increase of 12% in Cmax and an increase of 15% in AUC of sulfamethoxazole when sulfamethoxazole/trimethoprim was coadministered with Lialda [see DRUG INTERACTIONS].
Animal Toxicology And/Or Pharmacology
In animal studies with mesalamine, a 13-week oral toxicity study in mice and 13-week and 52-week oral toxicity studies in rats and cynomolgus monkeys have shown the kidney to be the major target organ of mesalamine toxicity. Oral daily doses of 2400 mg/kg in mice and 1150 mg/kg in rats produced renal lesions including granular and hyaline casts, tubular degeneration, tubular dilation, renal infarct, papillary necrosis, tubular necrosis, and interstitial nephritis. In cynomolgus monkeys, oral daily doses of 250 mg/kg or higher produced nephrosis, papillary edema, and interstitial fibrosis.
Clinical Studies
Active, Mild To Moderate Ulcerative Colitis
Two similarly designed, randomized, double blind, placebo-controlled trials were conducted in 517 adult patients with active, mild to moderate ulcerative colitis. The study population was primarily Caucasian (80%), had a mean age of 42 years (6% age 65 years or older), and was approximately 50% male. Both studies used LIALDA doses of 2.4 g/day and 4.8 g/day administered once daily for 8 weeks except for the 2.4 g/day group in Study 1, which was given in two divided doses (1.2 g twice daily). The primary efficacy end-point in both trials was to compare the percentage of patients in remission after 8 weeks of treatment for the LIALDA treatment groups versus placebo. Remission was defined as an Ulcerative Colitis Disease Activity Index (UC-DAI) of ≤ 1, with scores of zero for rectal bleeding and for stool frequency, and a sigmoidoscopy score reduction of 1 point or more from baseline.
In both studies, the LIALDA doses of 2.4 g/day and 4.8 g/day demonstrated superiority over placebo in the primary efficacy endpoint (Table 5). Both LIALDA doses also provided consistent benefit in secondary efficacy parameters, including clinical improvement, treatment failure, clinical remission, and sigmoidoscopic improvement. LIALDA 2.4 g/day and 4.8 g/day had similar efficacy profiles.
Table 5: Patients in Remission at Week 8
|Study 1
n/N (%)
|Study 2
n/N (%)
|LIALDA 2.4g/day
|30/88 (34.1)
|34/84 (40.5)
|LIALDA 4.8g/day
|26/89 (29.2)
|35/85 (41.2)
|11/85 (12.9)
|19/86 (22.1)
Maintenance Of Remission In Patients With Ulcerative Colitis
A multicenter, randomized, double-blind, active comparator study was conducted in a total of 826 adult patients in remission from ulcerative colitis. The study population had a mean age of 45 years (8% age 65 years or older), were 52% male, and were primarily Caucasian (64%).
Maintenance of remission was assessed using a modified Ulcerative Colitis Disease Activity Index (UCDAI). For this trial, maintenance of remission was based on maintaining endoscopic remission defined as a modified UC-DAI endoscopy subscore of ≤ 1. An endoscopy subscore of 0 represented normal mucosal appearance with intact vascular pattern and no friability or granulation. For this trial the endoscopy score definition of 1 (mild disease) was modified such that it could include erythema, decreased vascular pattern, and minimal granularity; however, it could not include friability.
Subjects were randomized in a 1:1 ratio to receive either LIALDA 2.4 g/day administered once daily or mesalamine delayed release 1.6 g/day administered as 0.8 g twice daily. The proportion of patients who maintained remission at Month 6 in this study using LIALDA 2.4 g once daily (83.7%) was similar to that seen using the comparator (mesalamine delayed release) 1.6 g/day (81.5%).
Last reviewed on RxList: 10/31/2014
This monograph has been modified to include the generic and brand name in many instances.
Lialda FDA Prescribing Information
Additional Lialda Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Separate names with a comma.
Well, try it and see if it makes any sense. Please post your times as well
On level 10 now and get: 10.945 as best (with start in 2nd gear)
I have upgraded the Aero TT within level 9 and tuned it a little
and manage to get 11.360 on the 1/2 track.
One could probably do better. Now...
How does the online racing system really work? Do they record the time of people and randomly lets you play against existing times?
I used to...
Cool, this helped me improve by .2 seconds and in effect win much more.
The best thing though: On the 1/4 track against the green car, I always...


text: home > heart center > heart a-z list > chest pain index Chest Pain Chest PainRelated Procedures & Tests « Back to Chest Pain Index Sorted Alphabetically A-Z Sort by popularity Angioplasty and Stents Cardiac Catheterization Chest X-ray Coronary Angiogram Coronary Artery Bypass Graft Coronary Heart Disease Screening Tests (CAD) CT Coronary Angiogram CT Scan (Computerized Tomography) Echocardiogram Electrocardiogram (ECG or EKG) Esophageal Manometry Exercise Stress Test Hemoglobin Parathyroidectomy Sorted by Popularity (as on MedicineNet) Sort alphabetically Hemoglobin CT Scan (Computerized Tomography) Angioplasty and Stents Coronary Angiogram Coronary Artery Bypass Graft Echocardiogram Parathyroidectomy Electrocardiogram (ECG or EKG) Exercise Stress Test Cardiac Catheterization Chest X-ray Esophageal Manometry CT Coronary Angiogram Coronary Heart Disease Screening Tests (CAD) Suggested Reading on Chest Pain by Our Doctors Related Diseases & Conditions 86 articles Rash The word "rash" means an outbreak of red bumps on the body. The way people use this term, "a rash" can refer to many different skin conditions. The most 12 Heart Attack Symptoms and Early Warning Signs Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms, including left arm pain and Low Blood Pressure (Hypotension) Low blood pressure, also referred to as hypotension, is blood pressure that is so low that it causes symptoms or signs due to the low flow of blood through Pleurisy (Pleuritis) Pleurisy, an inflammation of the lining around the lungs, is associated with sharp chest pain upon breathing in. Cough, chest tenderness, and shortness Abdominal Pain (Causes, Remedies, Treatment) Abdominal pain can have many causes. Some of the less serious causes include bloating, gas, colitis, endometriosis, food poisoning, GERD, IBS, and ovarian Lung Cancer Lung cancer kills more men and women than any other form of cancer. Eight out of 10 lung cancers are due to tobacco smoke. Lung cancers are classified Diabetes (Type 1 and Type 2) Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of Deep Vein Thrombosis (DVT) Deep vein thrombosis (DVT) is a blood clot in Dizziness Dizziness is a symptom that is often applies to a variety of sensations including lightheadedness and vertigo. Causes of dizziness include low blood pressure, High Blood Pressure (Hypertension) High blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and increased arterial stiffness Pulmonary Embolism (Blood Clot in the Lung) A pulmonary embolism (PE) occurs when a piece of a blood Peripheral Vascular Disease Peripheral vascular disease (PVD) Fatigue Fatigue can be described in various ways. Sometimes fatigue is described as feeling a lack of energy and motivation (both mental and physical). The causes Is Pneumonia Contagious? Pneumonia is inflammation of the lung usually GERD (Acid Reflux, Heartburn) GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the esophagus. The symptoms Cough (Chronic Cough) Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as Scoliosis Scoliosis causes an abnormal curvature of the spine. When the cause of scoliosis is unknown the disorder is described based on the age when the scoliosis COPD (Chronic Obstructive Pulmonary Disease) COPD or chronic obstructive pulmonary disease is a lung condition caused by Pneumonia Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Angina Angina is chest pain due to inadequate blood supply Pneumothorax A pneumothorax is free air in the chest outside the lung, that causes the lung to collapse (collapsed lung). There are two types of pneumothorax, spontaneous Fibromyalgia Fibromyalgia is a Psoriatic Arthritis Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Pulmonary Hypertension Pulmonary hypertension is an abnormal elevation of the pressure in the pulmonary circulation caused by the constriction of the blood vessels that supply Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma is Esophageal Cancer Esophageal cancer is a disease in which malignant Pericarditis Pericarditis is the inflammation of the Panic Attacks Panic attacks are sudden feelings of terror Cancer Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not See All Related Diseases & Conditions » Medications 18 articles Procedures & Tests 14 articles Pictures, Images & Quizzes 12 articles Doctor's & Expert's Views 12 articles Health News 116 articles Health Features 2 articles Heart Health Newsletter Sign up to stay informed with the latest heart-health related updates on MedicineNet delivered to your inbox FREE! BONUS! Get a Free Health & Wellness PDF Guide when you sign up! *Privacy Policy From WebMD Healthy Heart Resources Diabetes and Your Heart 22 Ways to Prep for Surgery Are We Close to a Cure for Cancer? Featured Centers Feeling Short of Breath? What to Eat When You Have Cancer Top 3 Anaphylaxis Triggers Health Solutions From Our Sponsors Frequent Constipation? Greater Food Accessibility Exclusives What Does Psoriasis Look Like? How to Prevent Muscle Cramps Blood Clot? Know the Signs and Symptoms Allergy Triggers: Do You Know Yours?