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Quotes & Info
|CHTP > SEC Filings for CHTP > Form 10-Q on 7-Nov-2012
|All Recent SEC Filings
Quarterly Report
The statements contained in this Quarterly Report on Form 10-Q that are not historical are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding the expectations, beliefs, intentions or strategies regarding the future. We intend that all forward-looking statements be subject to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. In particular, this "Management's Discussion and Analysis of Financial Condition and Results of Operations" includes forward-looking statements that reflect our current views with respect to future events and financial performance. We use words such as we "expect," "anticipate," "believe," and "intend" and similar expressions to identify forward-looking statements. A number of important factors could, individually or in the aggregate, cause actual results to differ materially from those expressed or implied in any forward-looking statement, including those set forth under "Part 1. Item 1A. Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2011 and in our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2012 and June 30, 2012 under "Part II. Item 1A. Risk Factors".
We are a development stage pharmaceutical company that seeks to acquire, develop and commercialize innovative products for the treatment of a variety of human diseases. Our strategy is to develop technologies that address important unmet medical needs or offer improved alternatives to current methods of treatment. Specifically, we are developing Northera™ (droxidopa), a novel therapeutic agent, for the treatment of symptomatic neurogenic orthostatic hypotension, or Neurogenic OH, in patients with primary autonomic failure (Parkinson's disease, or PD, multiple systems atrophy, or MSA, and pure autonomic failure, or PAF), dopamine-?-hydroxylase, or DBH, deficiency and non-diabetic autonomic neuropathy. We are also evaluating the potential therapeutic applications of droxidopa in reducing the frequency of falls in patients with Neurogenic OH associated with PD as well as other potentially norepinephrine-related conditions and diseases including intradialytic hypotension, fibromyalgia and adult attention deficit hyperactivity disorder. In addition, we have a portfolio of metabolically inert antifolates that we have studied as a potential treatment of rheumatoid arthritis and that might also be suitable for the treatment of multiple other autoimmune disorders including psoriasis, Crohn's disease, uveitis, ankylosing spondylitis, inflammatory bowel disease, cancer and other immunological disorders.
Northera, our most advanced investigational product candidate, is an orally-active synthetic precursor of norepinephrine being developed for the treatment of symptomatic Neurogenic OH. In Japan, Northera has been approved since 1989 and is marketed by Dainippon Sumitomo Pharma Co., Ltd., or DSP, for the treatment of frozen gait and dizziness on standing in PD, orthostatic hypotension, syncope and dizziness on standing in MSA (Shy-Drager Syndrome) and familial amyloid polyneuropathy and symptoms of orthostatic hypotension in hemodialytic patients. During 2007, the U. S. Food and Drug Administration, or FDA, granted orphan drug status to Northera for the treatment of symptomatic Neurogenic OH and the European Medicines Agency, or EMA, granted orphan medicinal product designation for the treatment of patients with PAF and patients with MSA.
During late 2011 and early 2012, we were focused on preparations for the potential commercial launch of Northera™ (droxidopa) in the United States in anticipation of FDA approval. In November 2011, the FDA accepted for filing our New Drug Application, or NDA, seeking approval to market Northera for the treatment of Neurogenic OH in patients with primary autonomic failure (including PD, MSA and PAF), DBH deficiency and non-diabetic autonomic neuropathy that we had submitted in September 2011. The clinical portion of the NDA included combined safety and efficacy data from our two completed Phase III studies in Neurogenic OH, Study 301 and Study 302, two long-term open-label extension studies, Study 303 and Study 304, a dedicated thorough QTc study and a 24-hour ambulatory blood pressure monitoring study, Study 305.
In February 2012, a meeting of the Cardiovascular and Renal Drugs Advisory Committee, or CRDAC, was held, at the request of the FDA, to review and discuss the Northera NDA. The CRDAC recommended, in a 7 to 4 vote, that the FDA approve our NDA to market Northera in the United States.
However, on March 28, 2012, we announced that the FDA had issued a Complete Response Letter, or a CRL, regarding our Northera NDA that included a request by the FDA that we submit data from an additional positive study to support efficacy. It was recommended that such a study be designed to demonstrate durability of effect over a 2- to 3-month period. Notably, the CRL did not identify any outstanding safety concerns. In addition, the FDA provided comments on the draft labeling submitted for Northera, including a preliminary recommendation to include a black box warning due to the lack of available data on patients in a fully supine position. However, the letter indicated that such a boxed warning could be reconsidered if suitable data demonstrating a lack of severe hypertension in a fully supine position were provided.
In May 2012, we completed an End-of-Review Meeting, or EOR, with the FDA to review the CRL and more fully understand the FDA's concerns regarding the Northera NDA. In preparation for this meeting, we prepared an information package, including a proposal for utilizing data from our then ongoing Study 306B to support the Northera NDA that called for a change in the primary endpoint of Study 306B to the orthostatic hypotension symptom assessment, or OHSA, item #1 score (dizziness, lightheadedness, feeling faint or "feeling like you might black out") at visit 4 (one-week post titration) and a recommendation to increase the number of patients targeted for enrollment in the study to approximately 200. Based on feedback received during the EOR, we submitted a revised protocol for Study 306B, proposing a change in the primary endpoint of Study 306B to OHSA, item #1 at visit 5 (two-weeks post titration) and supporting blinding documentation regarding the study for FDA review.
Also, given the concerns raised by the FDA at the EOR regarding results from the highest enrolling site in Study 301, we have submitted all information pertaining to two independent site visits, neither of which found any significant errors in the conduct of the trial, which was consistent with the positive findings from the FDA pre-approval inspection conducted during the review of the Northera NDA. Further, we have agreed to submit and are currently in the process of reviewing all source documentation from all patients at the site. We have also initiated reviews and inquiries into the data and conduct of this center from independent, third-party quality experts to confirm the validity of data from the site. Should the FDA decide to disregard the results of this site, the results of Study 301 would not be statistically significant and the study may not be deemed positive.
In June 2012, we received the written response, or General Advice Letter, from the FDA to our proposal to modify and utilize data from our then ongoing Study 306B. In its response, the FDA advised that, based on the theoretical potential for un-blinding, Study 306B is unlikely to provide sufficient confirmatory evidence to support a Northera NDA. The FDA was not confident that this information did not influence the conduct of the study or the statistical analysis plan. The FDA further recommended that we "design and conduct an additional trial to demonstrate that droxidopa has a significant and persistent effect" on symptoms of Neurogenic OH.
Soon after receipt of the written response from the FDA, we stopped enrolling patients in our Study 306B. Total enrollment was completed with 174 patients randomized, representing the single largest placebo-controlled study ever conducted in Neurogenic OH. In addition, we modified the primary endpoint of Study 306B to the mean change in OHSA item #1 score (dizziness, lightheadedness, feeling faint or "feeling like you might black out") at visit 4 (one-week post titration). The rate of patient reported falls is a secondary efficacy endpoint of the study. We anticipate that results of Study 306B will provide valuable efficacy and safety data. Results from this study are expected by the end of 2012. At that time we plan to finalize and reach agreement with the FDA on an additional study design to fulfill the requirements for our planned resubmission of the Northera NDA.
In addition to droxidopa, we have devoted resources to the development of a portfolio of molecules for the treatment of various autoimmune/inflammatory diseases. The most advanced platform is a portfolio of metabolically-inert antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity to treat a range of immunological disorders, including two clinical stage product candidates designated as CH-1504 and CH-4051.
In May 2012, we announced the top-line results of our completed multinational, 12-week, double-blind Phase II trial of CH-4051 in patients with rheumatoid arthritis, designed to compare the efficacy and tolerability of CH-4051 against methotrexate, currently the leading antifolate treatment and standard of care for a broad range of abnormal cell proliferation diseases. This Phase II trial was conducted in 244 patients with rheumatoid arthritis who experience an inadequate response to methotrexate treatment. Results of this trial indicated that CH-4051 did not demonstrate superior efficacy to methotrexate in the dose range evaluated. CH-4051 was found to be safe and well-tolerated in the study, with no dose-limiting toxicities or clear differences in the overall adverse event rate between methotrexate and the CH-4051 treatment groups. While management believes that higher doses of CH-4051 might provide enhanced therapeutic benefit in rheumatoid arthritis and that CH-4051 could be developed for other anti-inflammatory and autoimmune indications, we determined that current resources would be better allocated toward the planned completion of the Northera development program in Neurogenic OH. As such, there are no immediate plans to continue the development of CH-4051 although we do continue to discuss potential out-licensing opportunities for this portfolio of molecules.
Complementing our autoimmune/inflammatory program is a second platform consisting of a portfolio of therapeutics targeting immune-mediated inflammatory disorders and transplantation, known as our I-3D portfolio. We currently have no work underway related to this portfolio.
In July 2012, the Board of Directors announced the implementation of a corporate restructuring pursuant to which certain Board of Directors, management and workforce changes were effected. We significantly reduced headcount and retained only those employees necessary to support efforts to obtain approval to market Northera in the U.S. for the treatment of symptomatic Neurogenic OH. Concurrent with the restructuring, the Board authorized a plan to explore and evaluate strategic options for the Company, with the goal of optimizing long-term stockholder value.
Since inception we have focused primarily on organizing and staffing our company, negotiating in-licensing agreements with our partners, acquiring, developing and securing our proprietary technology, participating in regulatory discussions with the FDA, the EMA and other regulatory agencies and undertaking preclinical and clinical trials of our product candidates. We are a development stage company and have generated no revenue since inception. We do not anticipate generating any product revenue until and unless we successfully obtain approval from the FDA or equivalent foreign regulatory bodies to begin selling our pharmaceutical candidates although we could potentially generate revenue by entering into strategic agreements including out-licensing, co-development or co-promotion of our drug candidates. Developing pharmaceutical products is a lengthy and expensive process and the process for obtaining approval to market a product in the United States or elsewhere is complex and subject to numerous regulatory hurdles. As we recently experienced, we might encounter unforeseen efficacy or safety issues with our clinical trials, experience delays in our estimated timeframes for obtaining marketing approval of our currently licensed product candidates or experience other delays. Based upon the receipt of the CRL in March 2012 and subsequent correspondence from the FDA, we would not currently anticipate being able to submit a revised NDA for Northera until, at the earliest, 2013 but it is more likely that a revised NDA would be submitted subsequent to that, depending on the design and duration of additional clinical trials. Currently, development expenses are being funded with proceeds from prior equity financings and, to a much lesser extent, through the prior issuance of our common stock pursuant to option or warrant exercises. We completed equity financings in December 2004, February 2006, March 2007, November 2007, July 2009, March 2010, October 2010, February 2011 and January 2012. In addition, we received additional proceeds under a controlled equity offering for sales made during September 2010. To the extent we move Northera into additional clinical trials, our need to finance operating costs will continue. Accordingly, our success will depend not only on the safety and efficacy of our product candidates, but also on our ability to finance the development of our products (see "Liquidity and Capital Resources").
Critical Accounting Policies
Our management's discussion and analysis of our financial condition and results of operations is based on our financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States of America. Our significant accounting policies are more fully described in Note 1 to the financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2011 that was filed on March 7, 2012. The following accounting policies are critical in fully understanding and evaluating our reported financial results.
Use of Estimates. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent liabilities at the date of the financial statements as well as the reported revenue and expenses during the reporting periods. On an ongoing basis, management evaluates its estimates and judgments. Management bases estimates on historical experience and on various other factors that it believes are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results might differ from these estimates under different assumptions or conditions.
Research and Development Expense. Research and development costs are expensed as incurred. We often contract with third parties to facilitate, coordinate and perform agreed upon research and development activities. To ensure that research and development costs are expensed as incurred, we measure expense based on work performed for the underlying contract, typically utilizing a percentage-of-completion approach, and record prepaid assets or accrue expenses on a monthly basis for such activities based on the measurement of liability from expense recognition and the receipt of invoices.
These contracts typically call for the payment of fees for services at the initiation of the contract and/or upon the achievement of certain milestones. In the event that we prepay fees for future milestones, we record the prepayment as a prepaid asset and amortize the asset into research and development expense over the period of time the contracted research and development services are performed. Most fees are incurred throughout the contract period and are expensed based on their percentage of completion at a particular date.
These contracts generally include pass-through fees. Pass-through fees include, but are not limited to, regulatory expenses, investigator fees, travel costs, and other miscellaneous costs including shipping and printing fees. Because these fees are incurred at various times during the contract term and they are used throughout the contract term, we record a monthly expense allocation to recognize the fees during the contract period. Fees incurred to set up the clinical trial are expensed during the setup period.
Costs related to the acquisition of technology rights and patents for which development work is still in process are expensed as incurred and considered a component of research and development costs. In addition, the purchase of active pharmaceutical ingredient and manufacturing supplies for potential commercial product is expensed as incurred and considered a component of research and development costs prior to obtaining approval from regulatory agencies to market the product.
Accounting for Stock-Based Compensation. We account for our stock options and warrants utilizing a fair value based method of accounting. In determining the fair value of the equity instrument, we consider, among other factors, (i) the risk-free interest rate, (ii) the expected life of the options granted, (iii) the anticipated dividend yield, (iv) the estimated future volatility of the underlying shares and (v) anticipated future forfeitures. To determine the risk-free interest rate, we utilize the U.S. Treasury yield curve in effect at the time of grant with a term consistent with the expected life of our awards. We estimate the expected life of the options granted based on anticipated exercises in future periods assuming the success of our business model as currently forecasted. The expected dividends reflect our current and expected future policy for dividends on our common stock. To determine the expected stock price volatility for our stock options, we analyze the historical volatility of our stock price to determine an appropriate volatility factor. We plan to continue to analyze the expected stock price volatility, as well as other assumptions utilized in the calculations, at each grant date as more historical data becomes available. Our results of operations include non-cash compensation expense as a result of the issuance of stock option grants that are valued using this method. We expect to record additional non-cash compensation expense in the future, which might be significant. Due to the limited amount of historical data available to us, particularly with respect to employee exercise patterns and forfeitures, actual results could differ from our assumptions.
Results of Operations
Three Months Ended September 30, 2012 and 2011
The table below sets forth, for the periods indicated, certain items in our condensed consolidated statements of operations and other pertinent financial and operating data.
(in thousands, except percentages)
For the three For the three months ended months ended $ September 30, September 30, Increase/ % 2012 2011 (Decrease) Change Research and development expense $ 2,479,471 $ 7,417,477 $ (4,938,006 ) -67 % Sales and marketing expense 221,399 2,203,898 (1,982,499 ) -90 % General and administrative expense 1,169,157 1,278,085 (108,928 ) -9 % Restructuring 2,218,347 - 2,218,347 100 % Interest income 12,076 45,222 (33,146 ) -73 %
Research and development expenses. During the third quarter of 2012, we continued to incur costs for Study 306B and our open-label extension study, Study 304. Specifically, expenses for the third quarter of 2012 included approximately $0.8 million of direct study costs for Study 306 and $0.4 million for extension studies. During 2011, primary expenditures were associated with the preparation and filing of our Northera NDA, our ongoing Phase II trial of CH-4051, Study 306 and our NOH extension studies. Additionally, we incurred costs during the third quarter of 2011 related to medical affairs activities, including hiring, on a contract basis, a team of medical science liaison employees, generating period costs of $1.1 million. This contract was terminated in conjunction with the restructuring in July 2012. Also contributing to our expenses in both periods were compensation and related costs. As a percentage of operating expenses, excluding the impact of the restructuring, research and development costs were 64% for the third quarter of 2012 and 68% for the same period of 2011.
From inception through September 30, 2012, cumulative research and development expenses related to our major research and development projects were approximately $161.6 million and are detailed as follows:
Inception through (in thousands) For the quarter ended September 30, September 30, 2012 September 30, 2011 2012 Antifolates $ 50 $ 1,300 $ 43,500 Droxidopa 2,450 6,100 115,600 I-3D - - 2,500 $ 2,500 $ 7,400 $ 161,600
Droxidopa. From inception through September 30, 2012, we had spent approximately $115.6 million in research and development expenses on droxidopa. Research and development costs for the Northera Neurogenic OH core program include our Phase III trial, Study 306B, our access and safety program, Study 304, continuing regulatory activity and drug manufacture. Droxidopa-related development costs in the fourth quarter of 2012 are expected to remain at similar levels, including approximately $1.2 million in direct program expenses for Study 306B plus our extension programs for Neurogenic OH patients. We expect to spend approximately $0.3 million to complete these programs in the first quarter of 2013. Currently, we can provide no guidance around the costs of required new trials, if any, which may be necessary for the advancement of our Northera NDA as the design of such a trial, or trials, has not been determined.
Antifolates. From inception through September 30, 2012, we had spent approximately $43.5 million in research and development expenses on our portfolio of antifolates. In May 2012, we announced the top-line results of our completed Phase II trial of CH-4051 in patients with rheumatoid arthritis. Results of this trial indicated that CH-4051 did not demonstrate superior efficacy to methotrexate in the dose range evaluated. While we believe that higher doses of CH-4051 might provide enhanced therapeutic benefit in rheumatoid arthritis and that CH-4051 could be developed for other anti-inflammatory and autoimmune indications, we determined that current resources would be better allocated toward the completion of our Northera development program in Neurogenic OH. Although we continue to evaluate potential partnering opportunities for these compounds we currently have no immediate plans to continue the development of CH-4051.
I-3D Portfolio. From inception through September 30, 2012, we had spent approximately $2.5 million in research and development expenses on the I-3D portfolio of compounds. We have conducted compound discovery work on the portfolio to try and identify one or more lead compounds. All of the work completed to date was performed before 2008 and we do not expect to incur significant additional expenses for these compounds until we select a partner or obtain additional financing.
Sales and marketing expenses. We had no formalized selling activities during the quarter ended September 30, 2012 and our sales and marketing expenses decreased significantly when compared to the quarter ended September 30, 2011. During the third quarter of 2011, we spent considerable resources on supporting the development and implementation of sales and marketing initiatives for Northera in anticipation of a planned 2012 commercial launch. During the third quarter of 2012, the majority of these activities had been brought to a close as related vendor contracts were cancelled and projects finalized during the second quarter of 2012. Such activities included market research, sales force strategy and planning, planning and development of advertising and promotional campaigns, website development, sales operations, sales support systems implementations, employee training programs, sales force recruiting and public relations. We did incur an increase in legal expenses related to our intellectual property during the third quarter of 2012.
General and administrative expenses. When compared to the third quarter of 2011, general and administrative expenses remained flat in the same period of 2012. Decreases in compensation and related costs were offset by increases in legal fees associated with shareholder suits, accounting fees for tax return preparation in multiple jurisdictions and investor relations costs to support communications on recent corporate activity.
Interest income and interest expense. At September 30, 2012, we had cash and cash equivalents of $33.0 million. The decrease in interest income is primarily related to our decreased cash position and continued softness in the interest rate market in the United States.
Nine Months Ended September 30, 2012 and 2011 The table below sets forth, for the periods indicated, certain items in our condensed consolidated statements of operations and other pertinent financial and operating data. (in thousands, except percentages) For the nine For the nine months ended months ended $ September 30, September 30, Increase/ % 2012 2011 (Decrease) Change Research and development expense $ 15,874,135 $ 29,557,451 $ (13,683,316 ) -46 % Sales and marketing expense 6,943,327 4,639,245 2,304,082 50 % General and administrative expense 4,530,435 3,928,255 602,180 15 % Restructuring 2,218,347 - 2,218,347 100 % Interest income 58,444 131,120 (72,676 ) -55 %
Research and development expenses. During the first nine months of 2012, we continued to incur costs for Study 306B and our open-label extension study, Study 304 and had expenses for our now completed Phase II trial of CH-4051 in rheumatoid arthritis. We also incurred costs of approximately $0.2 million to support the preparation for the FDA requested meeting of the CRDAC held in February 2012 and our EOR meeting with the FDA, held in May 2012. Specifically, expenses for the nine months of 2012 included approximately $2.5 million of direct study costs related to our recently completed Phase II trial of CH-4051 and $3.5 million for Study 306B and our extension studies for Northera. Additionally, we incurred costs during the first six months of 2012 related to medical affairs activities, including a team of medical science liaison professionals, hired on a contract basis, generating period costs of $0.8 million. We also incurred approximately $1.8 million of expenses for the . . .


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Have you been stigmatized at all? When you go into auditions, have you noticed people looking at you in a certain way, assuming things about what kind of actress you are?
There are some, yeah. It's always the older crowd, the people who have been around for a long time who may have heard about the film but don't really know anything about it. They have their preconceived ideas of what it's about, and those are the ones who don't really give you a chance. But I've honestly had really good luck with everyone that I've worked with since—most people think it's cool. Like, "Yeah, you're really brave. You're not afraid to get dirty, ugly, and do something that's scary." That being said, though, there are those people who think I'll do whatever now. [Laughs.] And that's not the case, either.
In The Human Centipede II, you're playing a fictionalized version of yourself, and in the scene when Martin picks you up for the "audition," you came across as a diva-in-the-making. How much of that was scripted? Or was that all your own idea?
That was all just me talking, actually. It was all improv. Tom didn't write any dialogue down; he gave me a couple things that he wanted me to say. This is pretty much what he said to me: "I want you to play this really bitchy version of yourself, like most Hollywood actresses who think they're so cool because they've done one film." So I took it as, "Oh, yeah… Quentin Tarantino is asking me to audition for him," which is such a load of shit. [Laughs.] That's not going to happen.
Tom wanted to poke fun at Hollywood actresses who think they're hot shit because they did one film. He just said, "Be totally self-obsessed the entire time, and don't even notice Martin." He just let me riff. And none of what I said, like how we all took showers everyday before shooting scenes for the first movie—none of that is true. It was just all made-up.
In real life, if you were going to audition like that all by yourself, would you ever get in the car if you saw that the driver looked like Martin?
No, absolutely not! And that's the thing—it's not real. One, you don't sit in the front seat, and, two, I would never just walk into a secluded warehouse. [Laughs.] I'm smarter than that. And three, you always have to call your agent and tell them you landed, or at least email them right away. You always have to have contact with these people. You're not just being picked up by a stranger/driver who doesn't even speak. So there are all these elements that went into it that I always say to Tom, "This is absolutely incorrect," and he's like, "I know! It's inaccurate—it's totally inaccurate! Every single part of the film is totally inaccurate!" And all I can say is, "Exactly!" [Laughs.]
You talked about how disgusting the warehouse set was, but what was the mood like while filming all of these gruesome scenes of torture, mutilation, and, yes, defecation?
Oh my god, it's so fun on set. Because we know what we're making, especially me. I'm a goofball, and I know that we're making Centipede movies—we're not making War & Peace. [Laughs.] We're just making these funny films, and you have to have to a good sense of humor, especially when you're on all fours, being covered in duct tape and there's a fake butt strapped to your own butt. You just have to keep thinking, "My mom is so proud of me right now! I'm living my dream! This is what I've always wanted to do! When I was 14, this is what I said I wanted to do!"
When the film opened in theaters, I spoke to Laurence R. Harvey, and I was caught off guard by how friendly and warm he was, considering that I'd just watch him remain silent while killing people and making a human centipede.
Yeah, he's so sweet. When I first met him, I came on set so we could do our car scene together, and he came up to me and had this tin of candy, and said, "I wanted to give you a present—it's from my hometown." It was this little tin of mints. I looked at him and said, "You are creepy! Because this is what rape artists do when they meet you." [Laughs.] And he started laughing. But, yeah, he's such a gem; he's this amazing, sweet guy. I wish everyone could meet him in person, because he has such a great sense of humor, and you'd never know it from watching the movie.
What are your thoughts on the Valentine's Day release for the DVD and Blu-ray?
I thought it was hilarious, actually. When they told me that it was coming out on Valentine's Day, I said, "Of course it is." [Laughs.] Why would it be any other day than Valentine's Day?
Say you weren't in the movies, and a guy followed up a nice, romantic Valentine's dinner by bringing you back to his house and putting The Human Centipede's DVD on?
[Laughs.] I have no idea. I don't know what I would do, honestly. I'm not really into horror films, so I'd probably be a little freaked out, especially if I didn't really know him yet. I'd probably run for the door and get the hell out of there.
So you don't like watching horror films, generally?
Well, I do watch them a little more now. But I'm a huge scaredy-cat—I get scared to death by the Scream movies. [Laughs.] I like comedies.
It's funny, I think anyone who's been in a horror film automatically gets sent a ton of horror scripts as a result. It's such a small community, so once you get in it they keep asking you to be in more and more of them. For me, I just worry about whether I like the script and the character, no matter if it's a horror film or something else. I actually just finished shooting a film in New Orleans, with Vinnie Jones called Schism, and it's not really a horror film—it's more of a suspenseful thriller. I think it will be out in October, and I'm the lead female in it. I'm really proud of it, and I play the nice girl in the film.
So there aren't any scenes where you're on all fours, then?
[Laughs.] No, and it was so great. I was upright the entire time!
Interview by Matt Barone (@MBarone)
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January Jones in Goldsign Sissi Flares in Focus
January Jones is one celebrity who I think prefers flares over skinny jeans. We spot her out in flares all the time! Most recently, she wore a pair of Goldsign Sissi flares in Focus with a black sheer tee shirt and leather jacket, while promoting her film at Sundance.
I really like the monochromatic element of this outfit, with the different textures like leather and her sheer tee. Although, I do think January could have had these hemmed or worn taller heels, they're a bit long on her. Buy these jeans from Shopbop.com for $249.
Anna Friel in Goldsign Misfit Skinny Jeans in Motif
Anna Friel was pictured arriving at Soho House with a friend carrying a bouquet of flowers in London, England last week. She seemed to be all smiles as the paparazzi snapped photos of her.
Anna wore a pair of Goldsign Misfit skinny jeans in Motif with a Topshop Ombre Fringe jacket and open toe heels. When I first saw this jacket online a while back, I wasn't sure what I thought of it as it's quite a statement piece, but Anna manages to make it look really good! What do you think of the outfit? Buy Goldsign online at Shopbop.com and this jacket online at Topshop.com.
Images courtesy of Will Alexander/WENN.com.
Naomi Watts in Goldsign Jenny in Debut
Naomi Watts was seen running a few errands in Santa Monica wearing her Goldsign Jenny high rise jeans in Debut with a pair of black and white oxfords and a sweater.
Naomi has worn these jeans quite a few times, so have a few different celebrities like Rachel Bilson and Amber Heard. I think they fit really nicely and have a great slouchy look without being too large and still having a straighter style leg. You can buy these jeans from J Crew for $288.00.
Emily Blunt in Goldsign Lure Skinny jeans in Focus
Emily Blunt and her husband John Krasinski were seen arriving together at JFK airport. The couple was in town to attend the National Board of Review awards before they headed back to LA for the Critic's Choice Awards. I guess awards show season is in full swing!
I've always loved Emily's style because she always looks so chic, but never too overdone. For her trip she wore a pair of Goldsign's Lure skinny jeans in focus with a white sweater and wedge sneakers. I like how she rolled them up slightly at the ankle, I think they look nice with the sneakers! You can buy these jeans from Shopbop.com for $218.00.
Images from Pacificcoastnews.com


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LIBERTY -- Cindy and Larry McCale of Liberty are announcing the coming marriage of their daughter, Sherry McCale, to Manuel Rodriguez of Spring Lake, N.C., son of Evelyn Lopez and Martin Rodriguez Sr., both of Palo Alto, Calif.
The couple will be married at 1 p.m. June 16 in the Pocono Mountains. Invitations will be extended.
Miss McCale is employed at Redlon & amp; Johnson in Sharon, Pa.
Her fiance is serving with the U.S. Air Force stationed in Fayetteville, N.C.
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Whenever I activate the plugin, my homepage breaks, checking console I am getting this error:
ReferenceError: Can't find variable: WPGroHo
I am using a theme which displays full background images, with thumbnails scrolling across the bottom. When I activate the plugin only 1 thumbnail shows up. deactivating the plugin returns normal functionality.
my site is located at: http://picturesfor.me
I appreciate any/all help. I've used (and come to rely on) this plugin on several other sites I've built and am sorely missing it here.


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Ultimate Ears Super.fi 3 Studio earphones launch
Ultimate Ears has launched the Super.fi 3 Studio earphones, what they claim are £84.99 earpieces that transform everything from an Apple iPod to a portable DVD player or even an at-home mixing board into a "full-bodied sound stage".
The new earphones use a proprietary, vented, single-speaker design that has been engineered to deliver full-spectrum sound apparently previously unavailable even at a much higher price point, plus a special form factor that securely seals the ear against external noise.
The shape and fit - based on Ultimate Ears' 10 years of experience in handcrafting earphones from silicone impressions of customers' ears - are said to yield maximum wearing comfort as well as 26dB of noise isolation to ensure that you can hear the music instead of background noise.
Each pair comes with a leather case, an earphone cleaning tool, and a five-piece fit kit to adapt the earphones to different ear shapes.
The future of sound: KOAR Bone Conduction Bluetooth headset delivers audio to your inner ear
Harman Kardon Go + Play review: Post-retro design, powerful audio
Plex now lets you play music on any Sonos device from the Sonos app
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text:
Skip to comments.U.S. Navy Is Removing Life Support For Shipbuilding Industry
Posted on 07/11/2005 10:19:47 AM PDT by mr_hammer
Manufacturing News July 8, 2005 Vol. 12, No. 13 812 Words Page 1
U.S. Navy Is Removing Life Support For Shipbuilding Industry
The United States shipbuilding industry is on the verge of losing most of its component suppliers due to severe cuts in naval shipbuilding budgets and Department of Defense procurement rules that encourage acquisition managers to buy products from the lowest-cost commercial suppliers overseas, claims the American Shipbuilding Association.
Next year's proposed budget for naval ships is $3.2 billion less than the amount appropriated in 2005, says Cynthia Brown, president of the American Shipbuilding Association. Since 2001, defense spending has increased by 28 percent, which does not include supplemental appropriations, yet the naval ship procurement budget has declined by 33 percent. If present budgetary trends continue, the U.S. naval fleet will drop from 288 ships today to fewer than 200 ships by 2015.
The situation is becoming increasingly difficult for the six major shipyards, but it is even worse for U.S. equipment suppliers. "The Department of Defense has been working to repeal and weaken laws that require ships and certain ship components to be manufactured in the United States," said Brown in prepared testimony to the U.S.-China Economic and Security Review Commission. "The reliance on U.S. manufactured equipment is dissipating in response to pressure from DOD to open competition to foreign sources and to lower military specifications in an effort to reduce costs. DOD has been urging defense contractors to rely more on commercial off-the-shelf systems rather than systems built to military specifications. This emphasis on contracting with the lowest-cost producer is forcing all member companies of the defense shipbuilding industry base to source more of its material, components and systems foreign."
In most naval ship subsystem and component categories there is only one U.S. manufacturer remaining, Brown notes. Eighty-percent of the components manufactured for the Virginia Class submarine come from sole sources. "Production rates are not high enough to sustain more than one company and the companies left are struggling to stay in business," says Brown, whose membership includes the six major shipyards and 70 suppliers.
The U.S. industry, which employs 350,000 people, is producing six ships per year. (Market leader, Hyundai Heavy Industries of South Korea, produced 60 ships last year.) U.S. production is set to decline to four next year, due in part to the high cost of steel, a result of booming demand in China. The Navy says nine or 10 ships need to be built each year in order to have a 300-ship armada.
While the direction of the U.S. naval shipbuilding industry remains on a downward slope, the situation is the opposite in China. China is aggressively investing in its shipbuilding capacity. It is expected to have a submarine fleet that is twice the size of the U.S. fleet of 33 subs by 2010. It has started building a new class of destroyer that is "believed to match the air defense capability of the DDG-51 class," says Brown. "In 1989, China had essentially no shipbuilding industry or market share. In a little over a decade, China has invested in its shipbuilding industry to become the third largest builder of commercial ships behind South Korea and Japan."
China now has the capacity to produce 16-million deadweight tons a year. Its China State Shipbuilding Corporation recently announced a $3.6-billion shipyard construction project on Changxing Island. "Once completed, the shipyard is expected to have the capacity to produce more than 4.5-million deadweight tons a year, making it the largest shipyard in the world," says Brown.
China is also investing heavily in its component suppliers. It has stated that it wants 100 percent of all systems, components and materials to be produced in China.
"More and more manufacturing of ship components and systems will migrate to China as DOD encourages foreign sourcing in its efforts to find the cheapest sources," says Brown. "This has already begun with regard to materials for naval components. The manufacture of entire components and systems will migrate to China in the next several years under current DOD policy with respect to outsourcing."
The United States needs to address China's naval security challenge, Brown asserts. "If the industry is reduced further, the U.S. will have to reconstitute the industry if it is to counter the threat from China," she says. "Reconstitution of facilities and the skilled workforce, if possible, will be extremely costly and will take a decade."
She recommends that DOD's shipbuilding budget be sustained at between $15 billion and $16 billion a year, and that 12 combatant and logistics support vessels be built each year. At current rates, China will surpass the U.S. in naval vessels in 2015, based on the conservative estimate of China adding 12 ships per year. By 2024, China is projected to have more than 300 naval vessels, to about 180 for the United States.
The U.S. Congress should also require that naval ships and their components be manufactured in the United States, says Brown. "This action will ensure America's independence in determining its own destiny."
Can't possibly see any good to this given China's recent Naval build up. Not good, not good at all!
You mean like we did to the Soviet oil pipeline industry?
This is great news! We'll be able to save a bundle by buying warships on the cheap from the Chi-Coms. Maybe if we offer a bonus package, they'll deliver our new ships before the war breaks out.
There is no US ship building industry.
There was even a lame effort to build two US built cruise ships but that fell flat due to corruption and union thugs.
In the end US ship building has gone the way of the US merchant marine.
It just costs too much to flag a ship with a US flag. The navy deals were just a way to keep the knowledge if not the capacity alive.
The union thugs and the Democratic legislators they got elected created what they thought was the "ideal" laws and regulations. Now their actions are coming back to bite them in the a**.
The unions, socialists all, are responsible for this decay.
I was thinking the exact same thing.
It's just plain murder!!! Someone ping the Terri activists!
Why don't we just outsource our entire military overseas?
I'm sure the Chinese would be willing to provide us an Army to fight themselves.
Why not ask the Clintons?
and oddly the american merchant marine union sits on a pension fund of several hundreds of millions.
Unions are never about workers or jobs, unions are about controling and profiting from the administration of pension monies.
Don't forget Bill Clinton crowing that America isn't "the big dog on the block" anymore.
The Navy League is a good organization to join if you want to do something to stop the decline of the maritime industries in the United States.
They are very concerned about the Merchant Marine,ship building capacity in the US and the shortage of American mariners and seafarers. They have a strong caucus and are working with Congress to correct some of these deficiencies.
But China is no threat to us! Just ask President Bush and all the senators who voted for normalizing trade relations with the Chicoms.
I am quite afraid you are right!
Good post.
Who needs a Navy anyway, certainly not the free traders that have destroyed US industries. Keep shooping at Wal-mart folks. Go Free Trade Go! And don't forget to keep voting GOP too.
"(The level of sarcasm contained in this comment would ordinarilly involve the use of language inappropriate to these forums)"
Sarcasm is the coolest thing ever.
Can you believe some people don't like it?
Reminds of me of the Soviet Union's waining days. We're falling apart.
How soon before someone suggests nuking China...?
We only have 33 submarines?
".....due to corruption and union thugs."
Anything to back this up?
Hey...lets nuke China...lol
It starts in 5 minutes.
I still don't understand why we're so afraid of China. So what if they build up their military ? So did the Soviet Union, and look what happened to them. Let them waste their money.
So long as China has a communist government, they will forever experience internal difficulties and never be able to focus totally on external issues. China will never attack us, because they could never sustain their supply lines. History tells us that.
Don't you think the threat of not being able to sell us stuff will shape their foreign policy ? We've lived a long time without Chinese goods. We can live without them in the future if we want. Without our trade they have major problems (as do we, but that's another discussion). Why should we build up our military to match them ? Does anyone here ever think we'd go to war with a nuclear China (thank you bill clinton) ?
I trust that Rumsfeld is just working to implement a sensible policy that uses off the shelf components where they can be used reliably and with a major cost reduction. I would bet that we're generally avoiding Chinese sources and buying overseas from suppliers in Japan, Singapore, Malaysia, Taiwan, etc. (Obvious reason is that the Chinese would cut off supplies in the event of a military conflict with them.)
Somebody find Milton Friedman and have him explain why this is a good idea. He did so well with the volunteer army...
You are correct. Off the shelf works fine for field rations and oil filters. The more technical/capability specific, the fewer suppliers. It will be interesting to see the cost that foriegners will be charging us to move military freight oversease once the vessels are getting attacked.
I've been a sarcastic SOB all my life. I even throw in a dollop of cynicism!
I also like to tell outlandish lies to gullible people.
I trust that his judgement has not improved much since he supported Ford over Reagan in 1976. He's done nothing to clean out the Clinton era bureaucrats that were installed in the Pentagon. Apparently, he is sold on send/sailing the gals into combat as well. The US will pay a price for this someday, but likely it will be nobody in his family paying the price.
We don't need a navy when we can fly 60 year old Buffalos out of Kansas. Right?
I think out sourcing out military to china is a thought, china could fight the war on terror, and we could have our troops here patrolling our borders...
Last American Flag Steamship Line
Purchases American Built Container Ships
Perhaps ships and the shipbuilding industry are going the way of horse-drawn carts and buggy-whip manufacturers.
This site hangs black crepe. Most articles are pessimistic, sky-is-falling stories.
Which may be true. But it's very depressing.
Thanks for the ping!
China has already begun to attack us. The attack is political, so far. China is not your friend.
U.S. Attitude Shifts as Chinas Military Improves
By WILLIAM MATTHEWS, Defense News, July 11th, 2005
In 1991, U.S. precision weapons, night vision, stealth and other technologies dazzled the world by obliterating the Iraqi Army in four days. Among those most profoundly impressed by the U.S. accomplishment was China.
Awed by the power of U.S. technology, the Chinese military launched a sustained effort to modernize and reorganize its military, said David Finkelstein, an Asia expert at the Center for Naval Analysis.
A decade and a half later, its Americans who are beginning to be awed by what China has achieved.
The Chinese military has acquired an assortment of new weapons: Russian submarines and jet fighters, destroyers with state-of-the-art phased-array radar, airborne early warning aircraft, cruise missiles and wake-homing torpedoes, among others.
Stressing quality over quantity, China has cut the size of its military, yet increased its capability, Finkelstein said. It has developed new command-and-control doctrines and new standards for training troops.
Chinese military leaders know whats broken and what has to be fixed to make themselves a more capable, professional institution, Finkelstein said July 7 during a discussion on the Chinese military at the Heritage Foundation, a Washington think tank.
Chinas Ultimate Goal?
The question for the U.S. military is: What does China plan to do with its improving military power?
For U.S. military planners, who are conducting the Defense Departments Quadrennial Defense Review (QDR), Finkelstein said,it would be prudent to assume that China will continue to improve its military.
But it would be a mistake to assume that China inevitably harbors hostile intent toward the United States, he said.
That seems to be the assumption President George W. Bush and his administration are making, another expert said.
As recently as December, former Secretary of State Colin Powell referred to the U.S. relationship with China as the best in 30 years. But since then, there has been a noticeable shift in the way top administration officials discuss China, said John Tkacik, a research fellow in China policy at the Heritage Foundation.
In June, for example, Defense Secretary Donald Rumsfeld questioned continued increases in Chinese military spending.
Since no nation threatens China, one must wonder: Why this growing investment? Rumsfeld said.
Finkelstein contends that China perceives that it has legitimate defense needs. China fears Japan, wants to protect the access of its burgeoning industries to shipping lanes, and has reasons to worry about the aspirations of Asian neighbors such as India.
Tkacik offers this answer: China is preparing for a major war over Taiwan.
The U.S. military should pay attention to Chinas military advances, said Daniel Gouré, vice president of the Lexington Institute, a defense research center in Arlington, Va. There arent many uses for these advanced weapons except against an equally large and capable foe, he said
Gouré cautioned against those who have advised that the QDR focus on the war against terrorism. China and its role as a rising world power are at least as important as the war on terrorism, he said.
The forces needed to check the military power that China may become are substantially different from those optimized for the global war on terrorism.
Among the U.S. capabilities that have a clear impression on China is the ability to go downtown, Gouré said. China is pursuing defenses against the capabilities that enabled the United States to strike with impunity in Belgrade and Baghdad, he said.
If the Chinese succeed, the United States will be unable to operate aircraft other than stealth planes anywhere near China, Gouré said.
For the U.S. military, that creates a clear role for planes like the F/A-22, the B-2 bomber and a B-2 follow-on, he said. It also could increase the requirement for electronic warfare capabilities and very high-speed or hypersonic strike aircraft, he said.
In response to the Chinese military buildup, Gouré said U.S. planners conducting the QDR should give consideration to:
Maintaining a strong nuclear attack submarine fleet. Talk of reducing the fleet raises questions about how the Navy would maintain an adequate undersea presence in Asia.
Equipping aircraft carriers with better early warning aircraft, long-range unmanned aerial vehicles and stealthy F-35 fighters.
Keeping ship-based ballistic missile defenses in the region.
And we need a ground force capable of taking the war to China if that becomes necessary, he said. It may not be necessary or possible to march the U.S. Armys 3rd Infantry Division into Beijing, Gouré said. But U.S. military planners should consider putting U.S. troops on Chinese soil in ways that are persuasive.
Theres another threat the United States has yet to address: cyber defense.
Theres a lot of talk these days about the terrorist cyber threat. That pales in comparison to the ability of countries like China to put 10,000 or 20,000 trained people on the hacking circuit if they want to do so, he said. That is something you simply cannot ignore.
If all that sounds daunting to the United States, it may be more daunting to the Chinese, according to Finkelstein.
Chinas military modernization is occurring amid extraordinary economic growth, modernization and change in its society. In recent weeks, for example, riots have erupted among farmers over land disputes, students over rising university fees and peasants over the growing gap between rich and poor.
For Chinese government officials, the biggest problems lie not beyond the waters edge, but right at their doorstep, Finkelstein said.
The big story is about whether the Chinese Communist Party will succeed or fail in managing the rise of China at home, he said.
BAE Chief: Lower U.S. Tech Transfer Rules
By WILLIAM MATTHEWS , Defense News, July 11, 2005
The chief of Europes largest defense company is urging the U.S. government to ease rules that restrict foreign access to defense U.S. technology.
Dick Olver, chairman of London-based BAE SYSTEMS, said export controls imposed by the State Department are hindering the development of high-tech weapons such as the Joint Strike Fighter and data fusion technology that promises to improve battlefield situational awareness.
In addition, buy American sentiment in the House of Representatives in recent years threatens to further limit the ability of foreign companies to sell to the U.S. military. Olver called it misguided.
If buy American legislation prevails, it would impair the United States defense capabilities because it would prevent the U.S. taking full advantage of the global market, Olver said in a July 12 address at the Woodrow Wilson Center, a public policy research institute.
BAE has a particular interest in lowering the barriers that inhibit technology transfers and buying from foreign defense suppliers. Since 1999, the company has bought about a dozen U.S. defense firms. In March, BAE paid $4.2 billion to buy United Defense Industries, the maker of Bradley fighting and Marine Corps amphibious vehicles, naval guns, missile launchers and precision munitions.
BAE employs 35,000 American workers and expects to keep expanding in the United States, Olver said.
But even a trans-Atlantic company like BAE must get State Department approval before an American branch of the company can share sensitive technology with a British branch.
One result, Olver said, is that the United States has a hard time getting access to expertise it needs on short take-off and vertical landing a key feature in one version of the JSF.
We have been asked to lead the testing of this technology and to carry out operational modeling of mixed short takeoff and conventional takeoff options. But we can only do this if we receive the right approvals, Olver said.
BAE has hit a similar roadblock with data fusion technology. The company has developed ways to combine data from multiple sources to create a detailed picture of a threat, he said. Combined with U.S. capability, we believe we would be cutting-edge. But we are waiting for approval to contribute what we know in order to develop more capable, interoperable solutions.
One of the big losers because of U.S. export controls is the United States, Olver said.
Controls deny the United States access to tens of thousands of skilled engineers, scientists, companies and technology, he said.
One aim of U.S. technology transfer restrictions is to deny militarily important technology to U.S. enemies and potential adversaries. But Olver said strict British prohibitions mean there is no possibility that critical U.S. technology would be re-exported to prohibited countries such as China.
Sigh. This is such GARBAGE. We have more, and better skilled aerospace and electronics engineers now selling real estate and insurance for lack of employment BY OUR OWN DEFENSE INDUSTRY!!!!!!
And the "Global Market" is most assuredly not a good reason for furthering this abomination any further. The plane is either built entirely so as to DEFEND AMERICA...or it shouldn't be built.
If it's solely a flying pig farm, for the benefit of our allies, or merely to stymie the french fighter (much as I like to embarass them that's not a good enough reason to spend $220 billion U.S.), then it badly needs termination.
Put the money into the F-22...which is mostly American at least. And a TRUE air superiority machine. It rocks. Restored funding would let Lockheed get the economies of scale needed to really optimize our investment in this plane. The numbers would be there...
True. Many have chosen to not apply leather to pavement over and over looking for the next engineering position and have settled for the job security and continuity of working in a coal mine or driving a cab.
This guy has no idea how gaping is his knowledge deficit. He doesn't know what he doesn't know.
Very disturbing. My conclusion: He must be a product of a very recent public education...
A factoid: The transcontinental and spur railroads of the mid to late 1800s were partially funded by European investment. There was a huge crash in railroads four years after the continent was spanned when business didn't go quite right and European investment dried up. It wasn't all bad, but it was dislocating for a few years while the American economy reoriented itself.
I think the number is 55 at the moment. The 33 is a 2010 projection.
Thanks for the ping!
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What Israel Can Do Now
There are still actions Israel might take to protect itself from attack by Iranian nuclear weapons, including a limited Israeli strike on Iran.
There are still actions Israel might take to protect itself from attack by Iranian nuclear weapons, including a limited Israeli strike on Iran.
There is a middle way between more of the same and retaking Gaza. The proposed middle way would be an IDF attack with limited, achievable military objectives.
The West is headed towards an agreement with Iran, who will not produce nuclear weapons but further enrich uranium and plutonium. However, it is possible that Iran will be able to produce several bombs, too quickly to be stopped.
Israeli advocates of the two-state solution should support the findings of the Levy Commission, which affirms Israel's right to settle in the West Bank. Israel will thus be viewed as giving up its own territory in any future agreement.
If Israel strikes Iranian nuclear weapons facilities, the US should signal to Iran that despite America's strong objections, it would support Israel.
A strong Israeli response to Hamas rocket attacks is necessary to ensure Israel's ability to stand against the rising tide of Islamist militancy.
The Palestinians refuse to accept Israel as a Jewish state and are reluctant to drop their armed and ideological opposition to Israel's existence. The global community can oppose Palestinian denial of Israel's connection to the land; support Israel's legitimacy; resettle Palestinian refugees outside of Israel; modify aid programs to reduce Palestinian use of foreign money to support terror; and encourage free speech in Palestinian society.
The most important ways to work towards peace are: resettling the Palestinian refugees outside of Israel; speaking the truth to the Palestinians regarding the Jews' ancient roots in the land; reducing the ability of Palestinian leaders to personally benefit from the conflict; and encouraging free debate in Palestinian society.
Israel has to respond to the attacks from Gaza with a large-scale military operation. If no such action is taken, the attacks against Israel will surely increase.
Three forces are competing for control of Egypt: the army, the Muslim Brotherhood, and various civilian opposition groups. The military and civilian opposition must understand that the Brotherhood is their common and most dangerous enemy.


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With about one month left in the year, Wichita is on track to have one of its lowest homicide totals in a decade. So far, 16 homicides have been reported in 2013. Only 2005, which had 15 homicides, recorded fewer homicides in the last 10 years. The highest number of homicides in the last decade was in 2007, with 43. The Wichita Eagle reports city police are reluctant to discuss the reasons for the lower number of violent deaths. Capt. Brent Allred notes last year there were only 17 homicides through November, but then 11 more occurred before the end of 2012. Of the 16 homicides this year, four remain unsolved.
Location, ST | website.com


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Average RN salaries for job postings in Joliet, IL are 25% higher than average RN salaries for job postings nationwide.
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The study of cancer has been approached from a number of directions, which, for the most part, have been determined by the previous experience of the persons engaged in cancer research. Pathologists have been responsible for the search for infective organisms; biologists have elaborated the investigation of specific types of cell proliferation in connection with neoplasms; physiologic chemists have sought for evidences of fundamental alterations in tissue metabolism. This competition among different lines of scientific endeavor has been wholesome and stimulating to the study of disease, as it has furnished various points of view which would probably never have become recognized had it not been for the highly practical considerations which called forth so much effort on the part of many workers.
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Type: Posts; User: danbradster
If you consider the world overpopulated already, it'd be unethical to save them.
She goes to the club when her husband is away...
After not lifiting for 1+ month (ankle injury), coming back I would get dizzy really easily (especially from leg press). Maybe my muscles had only lost a little strength, while my...
liveleak .com/view?i=e1f_1304160048#Of615HVfObdjxWI9.99
Skip to 8:30
They work in a volcano with no breathing equipment, while smashing, deadlifting, squating and carrying sulphur rocks. ...
He means landing on the heels.
I think landing on the heals is natural when running slowly, but when sprinting, landing on the toes is more natural.
Eden Lake - scary because it's realistic about murderous English teens.
that's a plan.
Find a course that's worth studying that would make you certified as a personal trainer. It's far better than simply '1 year of training myself'. You'll have a qualification, job...
1 year of lifting and no qualifications. You'd be bringing down the average standard of personal trainers everywhere.
Getting a qualification will help (to not look like an idiot or hurt a...
Tip the day before the final exam, more depending on how badly you're going so far.
I believe the thread title should be 'GAWDAMMIT, ISIS executes another Westerner'. They execute more 'people' every day.
Cut off the heads of 100 Iraqi military and these same people hardly give...
Is this guy quitting high school or university? I hope he at least passed maths before quitting...maths/accounting is pretty important in business...
Question to OP: What's the price?
Question to Misc: Would you buy it?
Creatine is more effective than Whey Protein according to this literature review:
Alien Physiology
User with this ability either is or can transform into an Extraterrestrial/alien
Given both the near infinite variety of possible extra-terrestials, even only the ones in fiction,...
Isn't that just like what he said? Lift with proper technique, then stretch the muscle (with proper technique) for 20-30 seconds while contracting the antagonist muscle for maximum stretch.
Fitness first treadmills can do 20+ kmph. That's a quick pace, getting towards sprinting.
You could do plyometrics, which are pretty similar for your muscles. E.g. 5-10 vertical jumps or broad...
Very nice. Today I got 2 reps at 240lb, my grip was failing on the second rep. Any tips for me?
Ok, StrongLifts.
I find OHP pretty hard to progress...my squats can go up most sessions, but OHP less often...
I deadlifted 100kg, squatted 72.5kg, benched 55kg, OHPed 42.5kg this week. Your OHP is actually very high compared to your squat and deadlift, maybe you have decent arms and tiny legs. ;)
And other than the gun control ammo, it also killed a guy. Great decision, that one.


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Occupied Japan Cottage Sugar & Creamer - Pottery
Item #
Pottery Cottage Sugar & Creamer - Occupied Japan
Here is an adorable Occupied Japan handpainted cottage sugar & creamer set. The scene is a thatched roof with little windows and door and shrubbery. Very cute! Shows light crazing and a hairline on bottom, (not serious).Will be a great addition to your collection.ADD $7.00 SHIPPING IN THE USA.Shipping discount on multiple purchases.
Condition: One very small flake under rim.
Size: 4 inches tall
Country of Origin: JP
Manufacturer: Occupied Japan
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This is a discussion on Encounter with a rabid Neighborhood Patrol within the Off Topic & Humor Discussion forums, part of the The Back Porch category; Id love to see a picture of that van if you can get one sir hahaha...
Id love to see a picture of that van if you can get one sir hahaha
On a serious note this is Texas and Yahoos like that are ARMED,gives me the feeling they couldn't pass the tests to be real LEO's so they get on a neighborhood watch feeling like it gives them a feeling of playing LEO's.I would find out who is "In Charge" and let them know they aren't LEO's and have no business confronting anybody unless they happen to see a burglary in progress.
"Outside of the killings, Washington has one of the lowest crime rates in the country,"
--Mayor Marion Barry, Washington , DC .
In quite a few different states you are not allowed to detain anybody even if they are on your property, that can be considered holding you against her will and kidnapping, I would have asked them are you holding me against my will, if they say no, just go on your way, but if they say yes I would call 911 immediately, telling them you are being detained held against your will illegally that you want to press charges. It sounds like these two guys want to play police officer, they need to be put in their place before somebody gets hurt
You did nothing wrong period but they broke the law & the LEO condoned it & admonished you for not submitting to their illegal acts & harassment.
When are people going to figure out what watch means?
Everyone has an opinion & this is just mine sorry if it offends anyone.
ALSO I don't HATE LEOs I just Hold them to a Higher Standard of the LAW & nothing anyone says will change my opinion on this
I suspect the LEO gets a lot of calls from the "neighborhood Watch" . He was most likely trying to minimize his headaches. The groups do need to know they can't detain you or are you required to answer any questions. Maybe file a complaint with the Dept about the Yahoo's and they may have chat with them
Sent via Mental Power
The CCW Sash won't cause that............
Last edited by Rock and Glock; September 3rd, 2012 at 10:30 PM.
Have Laptop, Will Travel
I would definitely have a talk with the chief of police. Neighborhood watch groups are sanctioned by the PD. If their behavior is illegal or just offensive it needs to be corrected. Also the officer whom you spoke with needs a little coaching too, concerning the rights of citizens. Keep us posted on any future developments.
As far as the LEO...he was not as bad as I guess it sounded. He had a report and he repsonded. I had to stop for him. He was just trying to soothe over the feelings of the patrol dudes. He didn't beleive their actions were correct and told them.
As far as the nipple situation...that is under control LOL.
Just tell them it's wonderful they are out there helping Neighborhood Watch, you are out for a run, and thanks... but got to get my running in ... and keep going.
I don't make jokes. I just watch the government and report the facts. --- Will Rogers ---
Chief Justice John Roberts : "I don't see how you can read Heller and not take away from it the notion that the Second Amendment...was extremely important to the framers in their view of what liberty meant."
Surely this was thoroughly explained during NW training - they just don't get it and need to sit at home watching Cops.


text:
Dense deposit disease
Other Names for this Disease
- Glomerulonephritis membranoproliferative type 2
- Mesangiocapillary glomerulonephritis type 2
- Membranoproliferative glomerulonephritis type II
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. About half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start. DDD can have genetic or non-genetic causes. It can be caused by mutations in the C3 and CFH genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. Most cases are sporadic (occurring by chance in people with no history of the disorder in their family).[1]Dense deposit disease (DDD) is a condition that primarily affects kidney function. Signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. The major features of DDD are due to kidney malfunction, and often include
Last updated: 12/15/2014
- Dense deposit disease. Genetics Home Reference. February 2011; http://ghr.nlm.nih.gov/condition/dense-deposit-disease. Accessed 12/12/2014.
GARD Video TutorialsLearn how to find information on treatment, research, specialists, and more.
Your Questions AnsweredView questions about this condition answered by GARD Information Specialists. You can also submit a new question.
On this page
Basic Information
- Genetics Home Reference (GHR) contains information on Dense deposit disease. This website is maintained by the National Library of Medicine.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch's tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Dense deposit disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
- Glomerulonephritis membranoproliferative type 2
- Mesangiocapillary glomerulonephritis type 2
- Membranoproliferative glomerulonephritis type II
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


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This study introduces a mixed H2/H∞ fuzzy output feedback control design method for nonlinear systems with guaranteed control performance. First, the Takagi-Sugeno fuzzy model is employed to approximate a nonlinear system. Next, based on the fuzzy model, a fuzzy observer-based mixed H2/H∞ controller is developed to achieve the suboptimal H2 control performance with a desired H∞ disturbance rejection constraint. A robust stabilization technique is also proposed to override the effect of approximation error in the fuzzy approximation procedure. By the proposed decoupling technique and two-stage procedure, the outcome of the fuzzy observer-based mixed H2/H∞ control problem is parametrized in terms of the two eigenvalue problems (EVPs): one for observer and the other for controller. The EVPs can be solved very efficiently using the linear matrix inequality (LMI) optimization techniques. A simulation example is given to illustrate the design procedures and performances of the proposed method
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Address: 404 South Burdick, Kalamazoo, MI 49007 : Click for Map and Directions
Box Office Telephone Number: (269) 345-6500 (No phone orders available through the State Theatre Ticket Office – we are an in person service only)
Box Office Hours:
Thursday & Friday 11AM – 6PM
*With exceptions for PreSales and OnSales when applicable.
Weekend Hours: Open 3-4hrs prior to an event. If there is no event then we are closed. Please call ahead if you have questions pertaining to a specific showtime.


text:
Hi. I added a gift category to my existing products to categorize those products into gifts, but they don't show up in my site.
However, if I add a new product and list it as a gift category it works.
So only existing products don't get listed as in a gift category but new products get listed.
Any idea? please help.
Thank you,


text:
: Silver hack:
Pokémon Dark Energy - Beta 4 Available
View Single Post
September 26th, 2012 (7:54 AM).
Dark Energy is back in action! ;)
Join Date:
Oct 2008
A small country in the North
Originally Posted by
Eeeep. I actually swing by this thread every now and again to see how things are going, and I'm actually pretty darn excited to play this. GSC were, hands down, my favourite Pokemon games, and you've managed to turn Silver into something very nice indeed, by the looks of it. Keep up the great work! I eagerly await more info, and hope to actually get around to playing this soon. :D
You know what? You got in me in good mood by saying this so... screenshot time!
Yeah, I felt like I should finally get stuff done which I somewhat promised to do so here you go. Post feedback on the screenshots while at it, I know you like 'em
What could have Ashlyn been thinking when she said that? There is simply no way you could travel back in time!
More of a joke here. Guess what game this is line is based on? I'll give you a hint, the name begins with "I ..."
Yay, a trading house! Nothing too special here really, you can trade with people, talk with them but what is surprising is that there is a gentleman here who'd like to trade your Super Onix for something special if you got one. What could this guy be up to?
And... we're trying to find gym leader Ichirou who is also described as a great ninja. It seems he got our Pidgeot somewhat unguard, maybe by throwing a weapon on it or something?
And between Areas 112 and 115, you'll run into a couple of trainers which seem to be looking for something precious. Perhaps a pokemon that someone saw hiding in these parts earlier?
Oh no! Grandma has lost her grandaughter Elena who has obviously come hiding in this cave (while they're playing hide and seek). If we find her and bring her back, maybe grandma will reward us for doing so... This is a little mini-game where the girl actually follows you and you get to walk yourself by the way.
And that's all for today! Some feedback on the images would be appreciated
My Rom Hack
Learn how to hack GB/C games:
Check my GameBoy/Color hacking videos in Youtube
-The video set uses Pokemon Silver (U) rom for demonstrations
Joined Oct 2008
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text:
Dental assistant resume sample
If updating your resume is like getting a root canal, check out our dental assistant resume sample for ideas on how you can give your resume a routine cleaning.
View and download the Dental Assistant resume template in Word.
Search for dental assistant jobs.
Learn more about healthcare careers.
Dental Assistant Resume Sample
Mindy Rogers, CDA
55 Lakeview Drive
Sometown, FL 32074
Certified Dental Assistant
Expanded Functions Dental Assistant (EFDA) offering excellent clinical and customer relations skills gained through seven years of experience within high-volume dental practices. Display a warm, friendly demeanor and gentle touch during all dental procedures, earning consistent praise from patients and employers. Efficient and precise in chairside dental assisting.
Credentials include:
Florida Department of Health Certified Dental Radiographer | CEREC Certified | CPR Certified
Clinical & Computer Skills
Teeth Cleaning | Dental Radiographs
Bleaching Tray & Temporary Crown Fabrications | Instrument Sterilization
Temporary Fillings | Periodontal Dressings | Operatory Preparation
Model Casting | Preliminary Oral Health Exams | Fluoride & Sealant Applications
Dexis | Dentrix | Eaglesoft
Professional Experience
ABC DENTAL ASSOCIATES, Sometown, FL
Dental Assistant, 2007 to Present
- Efficiently manage patient care, office and laboratory duties within a multispecialty dental group employing 15 dentists and 32 dental assistants.
- Expose and process dental X-rays; maintain patient records and lab equipment; sterilize instruments; assist office manager with patient scheduling, billing and insurance claims; and educate patients on postoperative and general oral health care.
- Maintain clean, sterile and positive environments optimizing patient comfort and safety.
- Built a loyal patient following; frequently requested by patients to serve as their dental assistant.
DEF DENTAL OFFICE, Sometown, FL
Dental Assistant, 2005 to 2007
- Worked chairside assisting family dentist with routine cleaning and specialized procedures, making patients feel as relaxed as possible and preparing them for treatment.
- Gained experience in exposing and processing X-rays; fabricating crowns, pouring impressions, trimming models and preparing orthodontic equipment; and assisting with extractions, impactions, fillings, implants, local anesthesia, suture placements/removals and biopsies.
Dental Assistant Training
ABC DENTAL TRAINING SCHOOL, Sometown, FL
Dental Assisting Diploma (CODA-accredited program), 2004
Certified Dental Assistant (CDA), 2004
GHI PROGRAM, Sometown, FL
Completed Florida Board of Dentistry-approved radiology course, 2005


text:
Wikipedia:Wikipedia Signpost/2009-06-01/Technology report
Bugs, Repairs, and Internal Operational News
This is a summary of recent technology and site configuration changes that affect the English Wikipedia. Please note that some bug fixes or new features described below have not yet gone live as of press time; the English Wikipedia is currently running version 1.28.0-wmf.12 (c4e65e8), and changes to the software with a version number higher than that will not yet be active. Configuration changes and changes to interface messages, however, become active immediately.
New MediaWiki skin developed by Usability project team
The Wikipedia Usability Initiative project team has developed a new skin (Vector) based on the default Monobook skin, with improvements influenced by usability testing and research. Changes include moving the search box to the upper-right corner of the page. Monobook will remain the default skin, however users will be able to try out the new Vector skin by selecting it in user preferences. The skin will be available once r51094 goes live on Wikimedia servers.
StringFunctions extension merged with Parser Functions
The StringFunctions extension has been merged with the ParserFunctions extension, per bug 6455. These functions will be available once r50997 is pushed live to the Wikimedia servers.
The new functions include:
- len (
{{#len:string}}) - provides the number of characters in a string.
- pos (
{{#pos: string | needle | offset}}) - Finds first occurrence of "needle" in "string" starting at "offset".
- rpos (
{{#rpos: string | needle}}) - Finds last occurrence of "needle" in "string".
- sub (
{{#sub: string | start | length }}) - Returns substring of "string" starting at "start" and having "length" characters.
- count (
{{#count: string | substr }}) - Returns number of occurrences of "substr" in "string".
- replace (
{{#replace:string | from | to | limit }}) - Replaces each occurrence of "from" in "string" with "to", and "limit" replacements at most are performed.
- explode (
{{#explode:string | delimiter | position}}) - Breaks "string" into chunks separated by "delimiter" and returns the chunk identified by "position".
The string parser functions will only work for strings up to a maximum length of 1000 characters.
Other new features
- More improvements have been made to the new search interface (development in progress), including adding select all/none toggle buttons for the advanced search page where users can pick any combination of namespaces to search, (r51228) an option to search all namespaces, (r51243) and the create article link will only be shown for content namespace and search everything searches. (r51246)
- Subpages have been enabled in several namespaces: Help, Help talk and Category talk effective immediately (bug 18437), and MediaWiki as of r51153
- ISO speed rating has been added to the default collapsed EXIF metadata displayed on file pages. (r51038, bug 11484)
Other news
- The toolserver was out of service for some time on Thursday, May 28 due to a broken switchport. [1]
- New servers have arrived at the Amsterdam hosting facility, to be used for the toolserver. The new servers will provide a place for user home directories, and be used for replacing zedler (s2 database), a second login server, and the map toolserver. [2]
It should be noted that the code for StringFunctions has not yet been reviewed, and that it is still possible (perhaps probable) that it will be reverted before the next code update. — Werdna • talk 09:10, 2 June 2009 (UTC)
- If that happens, we can say so in a future Signpost report. But, there are code changes going back to April that are still tagged as "new". Most are not reverted, but some are and can be mentioned here if it's significant. --Aude (talk) 11:44, 2 June 2009 (UTC)
- As you predicted, Tim Starling disabled StringFunctions by default in r51497. – Minh Nguyễn (talk, contribs) 03:34, 7 June 2009 (UTC)


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text:
Chantler, who can play at left-back or in midfield, has missed the last three games due to ankle ligament injury and Welsh has seized his chance after making his first start of the season in the recent home draw with Scunthorpe.
Welsh retained his place in last week's win at leaders Tranmere and with Matty Robson set to continue in defence, the 29-year-old should line up again in midfield.
Striker Rory Loy is hoping to retain his place up front after scoring his first goal in over a year last week following his year-long lay-off with a broken leg.
Experienced defenders Mike Edwards and Peter Murphy are pushing for recalls and teenagers Dave Symington and Mark Beck are set to resume on the substitutes' bench.
- Sports & Recreation
- Matty Robson


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