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A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac Death
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Background— Although a heritable basis for sudden cardiac death (SCD) is suggested by the impact of family history on SCD risk, common genetic determinants have been difficult to identify. We hypothesized that a common variant at chromosome 9p21 related to myocardial infarction would influence SCD risk.
Methods and Results— This was a prospective, nested, case-control analysis among individuals of European ancestry enrolled in 6 prospective cohort studies. Study subjects were followed up for development of SCD, and genotypes for rs10757274 were determined for 492 sudden and/or arrhythmic deaths and 1460 controls matched for age, sex, cohort, history of cardiovascular disease, and follow-up time. Conditional logistic regression with fixed-effects meta-analysis assuming an additive model was used to test for associations. When individual study results were combined in the meta-analysis, each increasing copy of the G allele at rs10757274 conferred a significantly elevated age-adjusted odds ratio for SCD of 1.21 (95% confidence interval, 1.04 to 1.40; P=0.01). Controlling for cardiovascular and lifestyle risk factors strengthened these relationships (odds ratio, 1.29 per G-allele copy; 95% confidence interval, 1.09 to 1.53; P=0.003). These results were not materially altered in sensitivity analyses limited to definite SCD, in models that further controlled for the development of interim cardiovascular disease, or when the highly correlated variant rs2383207 was tested.
Conclusions— The major allele of a single-nucleotide polymorphism previously associated with increased risk of coronary artery disease events is associated with increased risk of SCD in individuals of European ancestry. Study of the mechanism underlying this association may improve our understanding of lethal cardiovascular disease.
Received February 2, 2009; accepted September 16, 2009.
Sudden cardiac death (SCD) results in 250 000 to 400 000 deaths in the United States annually.1–3 Coronary heart disease (CHD), with or without myocardial infarction (MI), is the most common substrate underlying SCD in the Western world, being responsible for ≈75% of SCDs.4–7 However, the majority of individuals who die suddenly are not in recognized high-risk subsets,8 and more than half have no clinically recognized heart disease before death.9 Therefore, improved methods that more accurately identify individuals at risk for SCD within the general population are needed to significantly reduce the overall incidence of SCD. Because there is a heritable component to SCD risk,10–14 genetic factors may help us better identify those at risk.
Clinical Perspective on p 2068
To date, rare mendelian syndromes such as congenital long-QT syndrome or hypertrophic cardiomyopathy have been found to contribute to a minority of SCD cases in adults15 but are typically the result of rare variants, private to individual families.16 Although the majority of SCD cases occur in the general population rather than among high-risk subsets,8 the overall annual incidence in middle-aged to older adults is low (0.1% to 0.4%).17–19 Thus, few prospective studies have adequate power to examine the role of genetic variants in the primary prediction of SCD, and at present, the search for common variants relevant at the population level has met limited success.20,21
Common variants at a locus on chromosome 9p21 near the CDKN2A and CDKN2B genes have recently been associated with CHD and MI,22–26 as well as abdominal aortic and intracranial aneurysms.27,28 We hypothesized that alleles of these common variants, which have been associated with multiple manifestations of vascular disease, might also be associated with SCD within the general population. To increase the number of SCD cases without decreasing our specificity for arrhythmic death, we chose to pool cases from 6 National Institutes of Health–funded prospective cohorts within the Brigham and Women's Hospital and the Harvard School of Public Health to test for an association between a common polymorphism at the 9p21 locus and SCD among individuals of European ancestry.
Study Populations
The study design is a case-control investigation sampled from prospective cohorts and clinical trials, taking advantage of the time-to-event data by matching cases and controls on follow-up time. The prospective cohorts included in the present investigation include the Physicians' Health Study (PHS I and II), the Nurses' Health Study (NHS), the Health Professionals Follow-Up Study (HPFS), the Women's Health Study (WHS), and the Women's Antioxidant Cardiovascular Study (WACS). Together, these cohorts include a total of 38 975 men and 67 093 women with stored blood samples. Details of the cohorts, along with the blood sample collection, are outlined in Table I of the online-only Data Supplement. In brief, the NHS and HPFS are prospective, observational cohort investigations; the PHS I, WHS, and WACS were initially randomized trials of aspirin and/or vitamin supplements in which treatment has ended. Prospective follow-up is ongoing in the PHS I and WHS. The PHS II is an ongoing randomized trial of vitamin supplementation. Information about medical history, lifestyle choices, and incident disease is assessed either annually or biennially by self-administered questionnaires.
End-Point Confirmation
The study end points included incident cases of sudden and/or arrhythmic cardiac death that occurred after return of the blood sample and before April 1, 2007. All cohorts used similar methods to document the timing and mechanism of cardiovascular deaths.29 Next of kin or postal authorities reported most deaths, and at the completion of each mailing cycle, the National Death Index was searched for names of nonrespondents to the questionnaire. Death certificates were obtained from state vital statistics departments to confirm reported deaths; if death certificates indicated possible cardiovascular disease (CVD), permission to obtain further information from medical records was requested from family members. For deaths that occurred outside the hospital, descriptions of the circumstances surrounding these deaths were obtained from the next of kin. Medical records (hospital, emergency room, autopsy, and emergency medical services reports) and accounts of the death from next of kin for all possible cardiovascular deaths (excluding strokes) were then reviewed by 2 cardiologists, and deaths were classified according to timing (the length of symptoms preceding the terminal event) and mechanism (arrhythmic versus nonarrhythmic). Information from the death certificate was not used in the classification.
A cardiac death was considered a definite SCD if the death or cardiac arrest that precipitated death occurred within 1 hour of symptom onset as documented by medical records or next-of-kin reports (n=389, 72.6%) or had an autopsy consistent with SCD (ie, acute coronary thrombosis or severe coronary artery disease without myocardial necrosis or other pathological findings to explain death; n=23, 5.4%). Unwitnessed deaths or deaths that occurred during sleep in which the participant was documented to be symptom free when last observed within the preceding 24 hours and circumstances suggested that the death could have been sudden were considered probable SCDs (n=93, 17.4%).4,17,30
Deaths were also classified as arrhythmic or nonarrhythmic on the basis of the definition of Hinkle and Thaler.31 An arrhythmic death was defined as an abrupt spontaneous collapse of the circulation (pulse disappeared) without evidence of prior circulatory impairment (shock or congestive heart failure) or neurological dysfunction (change in mental status, loss of consciousness, or seizure). Deaths before which the pulse gradually disappeared and/or those preceded by circulatory or neurological impairment were considered nonarrhythmic deaths, and these deaths were excluded from the SCD end point even if the death occurred within 1 hour of symptom onset. Deaths that fulfilled the criteria for arrhythmic death but were preceded by >1 hour of symptoms (n=31, 5.8%) were also included in the combined end point of SCD and/or arrhythmic cardiac death.
A total of 540 sudden and/or arrhythmic deaths occurred among participants who donated blood samples at baseline (Table 1 of the online-only Data Supplement), and 536 of these cases had DNA samples that passed our quality-control standards. Because very few SCD cases occurred among other ethnicities (n=20) in these predominantly white cohorts and to reduce the risk of population stratification, analyses were limited to SCDs among whites (n=516).
Selection of Controls
Using risk-set sampling,32 we randomly selected up to 3 controls from the same cohort for each case. These controls were also matched on sex, age (±1 year), ethnicity, smoking status (current, never, past), time and date of blood sampling, fasting status, and presence or absence of CVD (MI, angina, coronary artery bypass graft surgery, or stroke) at the time of blood draw. For the 69 cases who developed CVD after the blood draw but before their SCD, we selected a second set of 3 controls who developed CVD after the blood draw to explore how much of the overall association with SCD might be explained by the development of nonfatal CVD before SCD.
Genotyping and Quality Control
Genomic DNA was extracted from the buffy coat fraction of centrifuged blood with Qiagen Autopure kits (Valencia, Calif) in the NHS, HPFS, and WACS and from whole blood in the PHS I. In the WHS and PHS I, DNA was extracted by use of the MagNA Pure LC instrument with the MagNA Pure LC DNA isolation kit (Roche Applied Science, Penzberg, Germany). All assays were conducted without knowledge of case status, and samples were labeled by study code only. Matched case-control pairs were handled identically, shipped in the same batch, and assayed in the same analytical run to avoid batch effects. A common variant at the chromosome 9p21 locus that has been associated with CVD (rs10757274)23 was genotyped on the Sequenom platform (San Diego, Calif), which resolves allele-specific single-base extension products using mass spectrometry (MALDI-TOF)33 As a backup, a second highly correlated variant (rs2383207) was also genotyped on the same platform. Samples with successful genotyping on <60% of quality-control single-nucleotide polymorphisms (SNPs) selected from HapMap (typically performing well on this platform) were excluded from analysis. Genotypes for both SNPs passed our quality-control thresholds (call rate ≥90%; Hardy-Weinberg equilibrium; P>0.01 in controls). Blinded replicate quality-control samples were included and genotyped with 100% concordance.
Statistical Analysis
Means or proportions for baseline cardiac risk factors were calculated for cases and controls. The significance of risk factor associations was tested with the χ2 statistic for categorical variables and the Student t test for continuous variables. For each cohort, we investigated deviation from Hardy-Weinberg equilibrium using a χ2 goodness-of-fit test. We analyzed the association between the SNP and the risk of SCD and/or arrhythmic cardiac death using conditional logistic regression analysis. With risk-set analysis, the odds ratio (OR) derived from the logistic regression directly estimates the hazard ratio and thus the rate ratio or relative risk.32 Based on the genetic model underlying associations with CHD in prior studies,22,23 ORs were estimated for each cohort separately under an additive model of inheritance. The primary test of association was a fixed-effect meta-analysis conducted on the basis of the summary conditional logistic regression results for each cohort34; PROC MIXED of SAS (SAS Institute Inc, Cary, NC) was used to pool effect estimates over study cohorts using inverse variance weights. Tests for heterogeneity of the genetic effect across sites were conducted with the Q statistic.35
To allow secondary analyses, we examined pooled conditional logistic regression models that directly combined the individual cohort data. Results were similar, so secondary analyses combined the individual data for simplicity. In these pooled analyses, we examined as a secondary analysis a 2-df test of the 3 genotypes that did not assume an additive mode of inheritance. We tested for deviation from additivity by placing an additive term and a term for the heterozygotes in the pooled model. In secondary analyses, we explored the relation between genotype and SCD across categories of age, sex, smoking, or the prevalence of known CVD at the time of the blood draw both through pooled stratified models and by adding cross-product terms between genotype and the exposure of interest into the full pooled multivariable model. These secondary analyses were exploratory; therefore, they must be considered in light of multiple testing and should be considered hypothesis generating.
For all combined analyses (meta-analyses and pooled), conditional logistic regression models adjusting for increasing levels of CHD risk factors were performed. Of the matching variables, age and smoking were not perfectly matched, so these variables were also entered into the conditional logistic regression models to avoid any potential for residual confounding. The first primary model adjusted for age only. The second further adjusted for standard cardiac risk factors, including body mass index and history of diabetes, hypertension, hyperlipidemia, and smoking (current, past, never). The third additionally adjusted for alcohol intake (less than weekly, weekly, daily, ≥2 drinks per day), physical activity (at least once per week), and aspirin use (≥15 d/mo). The fourth further controlled for a family history of MI. Statistical analysis was performed with SAS statistical software, version 9.1 (SAS Institute, Inc).
Study Sample Characteristics
A total of 516 cases (188 women and 328 men) of SCD and/or arrhythmic cardiac death occurred among whites in the 6 cohorts over an average follow-up of 13.0 years. The clinical characteristics recorded at the time of the blood draw for the 516 cases and the 1540 age-, sex-, smoking- and CVD-matched controls are displayed by study cohort in Table 1. The mean age of the cases was 64.2 years, and 132 (25.6%) reported a history of CVD at the time of the blood draw. In pooled analyses, cases were more likely to report a history of diabetes and hypertension, to have a higher body mass index (P<0.001 for all comparisons), and to report a family history of MI (P=0.05). Cases did not differ significantly from controls with respect to a history of hypercholesterolemia and/or aspirin use. Among the controls, cardiac risk factors at baseline were not associated with genotypes of the rs10757274 variant at the chromosome 9p21 locus, with the exception of a weak association with lower rates of diabetes with increasing copy of the G allele (P=0.02; Table II of the online-only Data Supplement).
The genotyping call rates were 99.4% for rs10757274 and 99.7% for the backup SNP rs2383207. There was no difference in the call rate between cases (99.2%) and controls (99.4%). Of the total study group, 492 cases and 1460 matched controls were successfully genotyped for rs10757274. No deviation from Hardy-Weinberg equilibrium was detected in controls in any of the cohorts. As has been demonstrated in prior studies, rs10757274 and rs2383207 are in strong linkage disequilibrium (r2=0.87).
Primary Association Meta-Analyses
Table 2 displays the individual age-adjusted cohort-specific associations for rs10757274 and sudden/arrhythmic death from conditional logistic regression models under an additive mode of inheritance. Allele frequencies in the control groups were relatively homogeneous (P=0.29), and the pooled frequency was similar to that previously reported in other population-based cohorts of European ancestry such as the Atherosclerosis Risk in Communities and the Copenhagen City Heart Study.22 The association between rs10757274 and sudden/arrhythmic death was relatively consistent across the 6 studies, although within-study probability values for the most part did not reach significance, likely because of the smaller sample size. In all of the cohorts except PHS II, increasing copies of the G allele were associated with a higher OR for sudden/arrhythmic death, and the test for heterogeneity of the ORs was nonsignificant (P=0.34). When these ORs were combined in the meta-analysis, rs10757274 was significantly associated with sudden/arrhythmic death (OR, 1.21 per G- allele copy; 95% confidence interval [CI], 1.04 to 1.40; P=0.01; Table 2). When we repeated the age-adjusted analysis for the correlated SNP rs2383207, the results were consistent (OR, 1.23 per G-allele copy; 95% CI, 1.06 to 1.43; P=0.005; Table III of the online-only Data Supplement).
Further controlling for other cardiovascular and lifestyle risk factors (Table 3) resulted in consistent associations for rs10757274, with slightly higher point estimates but overlapping CIs. In the full multivariable model, the OR was 1.29 per G-allele copy (95% CI, 1.09 to 1.53; P=0.003). Results were not materially altered in sensitivity analyses limited to definite SCDs (n=384). Results were also unchanged after further adjustment for the interim development of nonfatal CVD after the blood draw (which occurred in 69 cases) by repeating the primary analysis with all cases but substituting a second set of controls matched for the development of CVD for these 69 cases (Table 3).
Pooled Analyses
When the individual data from the cohort studies were pooled and analyses were repeated, the results were similar to those from the primary meta-analysis. Each increasing copy of the G allele of rs10757274 was associated with a significantly elevated OR for sudden/arrhythmic death of 1.21 (95% CI, 1.05 to 1.41) in the age-adjusted analysis. Further controlling for other cardiovascular and lifestyle risk factors had a similar impact on the risk estimate for rs10757274 (OR, 1.27; 95% CI, 1.09 to 1.50; P=0.003). When examined in a 2-df model, the results were consistent with an underlying additive model, and the test for deviation from additivity was nonsignificant (P=0.38). Compared with minor allele homozygotes, the OR for the heterozygotes in the full multivariable model was 1.12 (95% CI, 0.85 to 1.50) for rs10757274, and the major allele homozygotes had the highest risk (OR, 1.60; 95% CI, 1.16 to 2.20), consistent with an additive genetic model.
Stratified Analyses
In exploratory secondary analyses, we repeated the full pooled multivariable analysis after individually stratifying on each of the matching variables of age, sex, smoking, and history of prior CVD individually (Table 4). The ORs associated with the risk allele were somewhat higher among those above the mean age of 64.2 years and among those with a history of prior CVD at the time of the blood draw, but the CIs for the risk estimates overlapped widely, and the P values for interaction in the full multivariable model were not significant. However, our power to detect such interactions is limited. Secondary analyses of the correlated SNP rs2383207 were very similar (data not shown).
In this combined nested case-control analysis from 6 prospective cohorts, a common variant at the chromosome 9p21 locus, previously associated with MI and CHD, was significantly associated with sudden and/or arrhythmic death in individuals of European ancestry even after matching for prior CVD and controlling for cardiovascular risk factors. The risk allele is common, with ≈50% of the population carrying 1 copy and having an estimated 29% increased risk of sudden/arrhythmic death after other CHD risk factors are controlled for compared with noncarriers. For the ≈25% of the population who are homozygous for the risk allele, the OR of sudden/arrhythmic death was elevated by an estimated 60% compared with those homozygous for the minor allele.
These data have important pathophysiological implications. The risk estimate observed here for SCD is remarkably similar to those previously reported for MI and coronary artery disease22,23,25 and likely represents an association between this variant and a common underlying pathology (coronary atherosclerosis). However, the variant was associated with SCD even after matching for and further controlling for prior CVD. Therefore, the observed association is probably not entirely explained by the detection of underlying atherosclerosis. The present data, along with prior associations documented between this chromosomal region and aneurysmal diseases (abdominal aortic and intracranial aneurysms)27,28 and the progression of atherosclerosis,36 suggest that the genetic locus may be involved in abnormal vascular remodeling and/or repair, which could increase the propensity toward more aggressive atherosclerosis and more unstable, rupture-prone atherosclerotic plaques, which could result in SCD.
Currently, the casual variant and mechanism underlying the association with vascular disease are not known. The SNP is located in a region on chromosome 9p21 of high linkage disequilibrium,24,26 which is devoid of known genes. The region is adjacent (≈115 kb) to the coding sequences of 2 cyclin-dependent kinase inhibitor genes, CDKN2A and CDKN2B, which are known to have critical roles in cell proliferation, aging, senescence, and apoptosis37 and which could play a role in atherosclerosis through their role in transforming growth factor-β–induced growth inhibition.38,39 However, it is also possible that a previously unrecognized gene or regulatory element within or near the region could be the causal variant. Deep resequencing of this region is required to obtain the full spectrum of variation and to identify the causal variant(s).
These data may eventually have clinical implications as well. The modest risk elevation conferred by this variant is unlikely to have immediate implications for risk stratification in isolation.40 However, given the 2-fold elevations associated with a family history of SCD and/or ventricular fibrillation, the 9p21 variant likely explains only a small fraction of the familial clustering of SCD. Therefore, it is likely that other susceptibility variants for SCD will be found, which, combined with other established and novel risk factors, may eventually allow the identification of a population at higher risk. Further investigation into the underlying mechanism may also lead to important insights into the underlying biology and point to novel causal pathways that can be targeted for intervention.
The present study has several strengths and limitations that warrant consideration. Strengths include the nested prospective case-control design, the large well-characterized cohorts, and the combined large number of rigorously confirmed SCD and/or arrhythmic cardiac deaths, a difficult phenotype to classify in population studies. Ascertaining cases and controls prospectively from a defined cohort reduces selection bias, and the ability to match on time at risk reduces the risk of survival bias. Potential limitations of this population-based study include the possibility of some degree of misclassification, particularly among the probable SCDs. However, results were unchanged when these probable SCDs were excluded from analysis. In addition, not all participants provided a blood sample (Table I of the online-only Data Supplement); therefore, these cases and controls could have differed in some respects from their respective source populations. Given the low frequency at which SCD occurs in the general population, we needed to combine cases from independent cohorts to achieve adequate power without decreasing our specificity for arrhythmic death, and the small numbers within each cohort did not allow us to independently replicate the association. However, the association has previously been replicated repeatedly with respect to other CHD end points. Moreover, these cohorts were composed of health professionals and used similar methodology for end-point documentation and risk factor ascertainment.
Population stratification (differences in ancestry between cases and controls) is a concern in any genetic association study and, if present, can lead to false inference of association for variants that have differing frequencies in different ancestral groups. However, the 2 variants tested, rs10757274 and rs2383207, are highly correlated only in European ancestry samples, and the concordance of the association results for the 2 SNPs in our samples of self-described white individuals provides strong evidence against the possibility of a false-positive association resulting from population stratification. Finally, the results observed in these cohorts composed entirely of health professionals may not apply to individuals in other socioeconomic strata who may be at higher risk for CVD or nonwhite populations, particularly blacks in whom the association between these variants and CHD has not yet been replicated.22
In this combined population of white men and women, a common variant at the chromosome 9p21 locus was associated with significantly increased risks of SCD and/or arrhythmic cardiac death, and this relationship was independent of established risk factors for CHD and/or SCD. These findings emphasize the important role that atherosclerosis plays in SCD even among relatively healthy free-living populations and may carry implications for further efforts to screen and prevent SCD in the general population. Because the majority of SCDs do not occur in high-risk individuals,8,9,29 improved identification of those at risk is crucial to reducing SCD mortality.
We are indebted to the participants in the Harvard Cohort Studies and their families for their outstanding commitment and cooperation. We thank Julie Pester, Lisa Dunn, Barbara Egan, Helena Judge Ellis, JoAnn Smith, and Olga Veysman for their expert assistance.
Sources of Funding
This project was supported by a grant from the National Heart, Lung, and Blood Institute (HL-068070 to Dr Albert). Additional support for the DNA extraction in the Women's Health Study came from the Donald W. Reynolds Foundation. Dr Albert is also supported by an Established Investigator Award from the American Heart Association. Dr Newton-Cheh has been supported by an award from the National Institutes of Health (K23-HL-080025), a Doris Duke Charitable Foundation Clinical Scientist Development Award, and a Burroughs Wellcome Fund Career Award for Medical Scientists. The cohort studies were supported by grants HL-26490, HL-34595, HL-34594, HL-35464, HL-043851, HL-46959, and HL-080467 from the National Heart, Lung, and Blood Institute and CA-34944, CA-40360, CA-47988, CA-55075, CA-87969, and CA-97193 from the National Cancer Institute.
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Kalinina N, Agrotis A, Antropova Y, Ilyinskaya O, Smirnov V, Tararak E, Bobik A. Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions. Arterioscler Thromb Vasc Biol. 2004; 24: 1391–1396.
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Sudden cardiac death (SCD) results in 250 000 to 400 000 deaths in the United States annually. Although coronary heart disease is recognized to be a potent risk factor and an acute mechanism for SCD, risk in individuals is poorly estimated, and improved risk prediction is needed. Given the aggregation of SCD within families, we sought to identify genetic factors associated with SCD risk in cases and controls of European ancestry drawn from 6 National Institutes of Health–funded prospective cohorts. We tested for an association between SCD and a common polymorphism, rs10757274, at the 9p21 locus, which has been robustly associated with coronary artery disease. We found that the G allele associated in prior studies with coronary artery disease was associated with a 29% increased risk of SCD per allele copy after adjustment for cardiovascular and lifestyle risk factors (P=0.003). This finding suggests that genetic factors that contribute to coronary artery disease also contribute to SCD risk. It also raises the possibility that the development of a genetic risk profile made up of multiple SCD variants could ultimately improve risk prediction for a lethal and poorly predicted disease.
The online-only Data Supplement is available with this article at http://circ.ahajournals.org/cgi/content/full/CIRCULATIONAHA.109.879049/DC1.
Guest Editor for this article was Kari E. North, PhD.
Continuing medical education (CME) credit is available for this article. Go to http://cme.ahajournals.org to take the quiz.
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- A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac DeathChristopher Newton-Cheh, Nancy R. Cook, Martin VanDenburgh, Eric B. Rimm, Paul M. Ridker and Christine M. AlbertCirculation. 2009;120:2062-2068, originally published November 23, 2009http://dx.doi.org/10.1161/CIRCULATIONAHA.109.879049
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- A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac DeathChristopher Newton-Cheh, Nancy R. Cook, Martin VanDenburgh, Eric B. Rimm, Paul M. Ridker and Christine M. AlbertCirculation. 2009;120:2062-2068, originally published November 23, 2009http://dx.doi.org/10.1161/CIRCULATIONAHA.109.879049
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Today the Cleveland Browns named Brian Hoyer the starting quarterback for Thursday's Week 5 game against the Bills.
Brandon Weeden (thumb) was fully cleared today, but there's no way the Browns can turn back to him now.
In two starts, Hoyer has gone 55-of-92 (59.7 percent) for 590 yards with five touchdowns and three interceptions.
Most importantly, he's led the Browns to a rare two-game winning streak. Now Hoyer gets a home game against a Bills secondary who is banged up with injuries.
This game is going to be good this week.

subset: commoncrawl


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Vizzywig - Video Editor Movie Maker and Multi Camera Film Edit Effects Slideshow Music Editing Credits App
By i4software
Open iTunes to buy and download apps.
Vizzywig is the first all-in-one, movie-making application for iPhone, iPad, and iPod touch that lets you record, edit, and preview in real time! See what the press is raving about! Tested extensively on iOS 8 and the new iPhone 6 and 6 Plus. Everything works perfectly. Check out our new "Create Music Video" feature!
VISIT: Vizzywig.com/support/
(For YouTube Tutorials and our Quick Start Guide PDF)
Import clips, add transitions, overlay snapshots and titles, set in/out points, split clips and set background music while you capture the event. When the event is over, simply tap DONE and your finished movie is rendered in minutes complete with a studio intro, titles, transitions and even Hollywood-style scrolling credits.
Vizzywig also lets you record and live-switch from up to 16 iOS devices at the same time using our amazing remote camera feature or create multiple-angle music videos in minutes with a single camera using our new "Create Music Video" multi-clip feature.
** Watch the demo: Vizzywig.com/demo **
• Edit while filming. Add music, credits & more
• Multi-camera recording & seamless sharing
• WINNER: Macworld "Best of Show" Award
• Import up to 30 clips or photos in one step
• Seamlessly record, edit and share your videos in minutes.
• Add transitions, preview your shots, trim clips and rearrange sequences.
• Insert intros, titles, credits, photos and music.
PLUS! Connect up to 16 iOS devices over Wi-Fi so you can view, switch camera angles, record and edit… all on the fly!
Here's what the critics are saying:
"Easy and powerful." – Jackie Dove, Macworld.com
"A robust multi-camera video-editing suite." – Kelly Hodgkins, TUAW
"You'll be the next Steven Spielberg in no time!" – Zach Walton, WebProNews
• NEW: Improved facial detection lets you record alone using several cameras.
• NEW: Lock focus and exposure for better control.
• NEW: Create multi-camera clips with a single device.
• Switch between front and rear cameras while recording.
• Snap photos while recording.
• Add optional date & time stamps directly into the video.
• Control zoom, focus, and exposure functions manually or automatically.
• Supports 1920x1080, 1280x720 and 640x360 resolutions.
• NEW: Hardware Video Stabilization
• NEW: Audio Meter
• NEW: 24p, 25p, 30p, 60p, 120p on supported devices.
• NEW: Add multiple background music tracks
• NEW: Expanded library of looping background music tracks.
• NEW: Copy audio from any recorded clip or any clip in your camera roll.
• Connect and simultaneously record from up to 8 devices linked over Wi-Fi.
• Capture the action from up to 8 unique angles.
• Receive remote camera clips at full resolution.
• Send or receive pre-recorded clips between devices.
• NEW: Insert "News Broadcast" titles over the bottom of your videos.
• Preview, trim clips and process your final movie right on the spot.
• Add fully customizable titles and scrolling credits.
• Move, duplicate, delete or load clips without exiting the main camera view.
• Enter full-featured editing mode for advanced users.
• Access songs from your own music library.
• Add a Hollywood feel with one of six professional-quality studio intros.
• Import .MOV files or clips from many popular cameras.
• NEW: Upload sessions with all edit details to DropBox or via iTunes Sharing.
• IMPROVED: Email or upload directly to Facebook, YouTube, Vimeo or CNNiReport.
• Select from 3 sharing resolutions for faster upload speeds or higher quality.
Now you can connect to and record from remote iOS devices over 3G, 4G or LTE anywhere in the world. We are currently inviting select users to a free 30-day beta of the service. If you would like to be considered, please send us an email to (invite at vizzywig dot com).
What's New in Version 5.0
MAJOR RELEASE: Version 5.0
Incredible New Features:
1. NEW Video Stabilization Feature on Settings Screen.
2. NEW Audio Meter Display Feature on Settings Screen.
3. NEW 1280x720 Resolution Option for Remote Camera and Create Multi-Camera Music Video on Settings Screen.
4. Now you can PAUSE and RESUME recording when you "Add Clip" on Multi-Camera Edit Switching "Add Clip" View.
5. NEW Frame Rates 24p, 25p, 30p and more on certain devices.
6. NEW Dropbox Support for uploading 1920x1080 movies, entire session packages and EDL files for desktop NLE import.
***Please rate Vizzywig on the App Store and write an honest review after using version 5.0.
Fixed a memory bug on iPhone 4S that would cause Vizzywig to crash on the Edit View "Play All".
Customer Reviews
Short Learning curve to great results
I haven't explored all the features of this, obviously very powerful app, but I was able to create several videos using clips from my phone without viewing the tutorials. I found it very intuitive and have instigated several smiles and laughs sharing the end product. About that, I tried to send a short clip via email and it's still churning in the outbox, not sure what the issue is there. I digress, I was able to import several clips from my phone, get rid of the original sound and added music, from my tunes on my phone, and edited the length of a clip all just by playing around with it. The transitions between clips are very smooth and there are several options. One other quirk, you- allegedly- can add credits at the end, but so far I've only been able to get the labels to show up, not the text I entered. Maybe I'll break down and watch a tutorial 😉 I look forward to more fun with this!
This is an incredible little app!!! I've been creating professional videos for many years and the capacity of my little iPhone and iPad for capturing video and editing on the fly has just kicked into high gear. The panning zoom is very smooth, one touch and it smoothly zooms in or out. The image stabilization is pretty good too. Editing took a little getting used to but when I submitted a few questions, they were answered very quickly. I quickly bought an XLR adapter for audio and can't wait to use it for when I want to put something together quickly. It is all about the story telling and this a quick and easy way to do a lot with something that fits in your pocket. So cool. A lot of thought was put into this app, I would highly recommend it!!!
Not reliable
The app has lots of great features but does not seem stable/reliable at this point. I'd give it a 4-5 stars if I didn't run into problems, but the problems I ran into make me want to give it a 1-2 so I'll split the difference at 3 stars
I recently bought Vizzywig 5.0 with hopes of recording my daughters violin recital using multiple cameras. A few short pre-recital test recordings went well recording from 2 iPod touches (4th gen) and an iPhone 5S to a retina iPad mini (the stage) (recorded locally with wifi). During the actual performance, about 9 minutes in, the app suddenly quit on the iPad. This seemed to stop the recording from the three "players". The 5S (the main camera) lost all data from the previous 9 minutes I assume it was the active player. I was able to restart the app and restart recording missing a couple of minutes of her performance.
The creator of this app described this app as "bullet proof" in a walk thru video on the 4.0 version. Based on how many times it has crashed for me since try to edit the recital record, the 5.0 version must be a step backwards.
In addition the audio is about 6 seconds out of sync with the video which I hope to be able to fix in iMovie.
Overall, it looks like editing this is going to end up taking me much more time than planned.
- $29.99
- Category: Photo & Video
- Updated: Mar 05, 2014
- Version: 5.0
- Size: 60.0 MB
- Languages: English, French
- Seller: ESS International Corporation
- © i4software
Compatibility: Requires iOS 4.3 or later. Compatible with iPhone, iPad, and iPod touch.


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Elastic Buckling Database for Thin-Walled Metal Columns with Perforation Patterns
Smith, Frank H.
MetadataShow full item record
Presented is the data set used in the development and validation of approximate finite strip methods for use in predicting elastic buckling strength of cold-formed steel columns including perforation patterns. The influence of perforations is accounted by reduced thicknesses related to the plate buckling coefficient and transverse web rotational stiffness in the prediction of local and distortional buckling respectively. Global buckling prediction including the influence of perforations uses critical elastic loads of an unperforated section multiplied by the ratio of weighted to gross cross-sectional moment of inertia for flexural buckling and the ratios of weighted to gross cross-sectional warping torsion constant and weighted to gross St. Venant torsional constant for flexural-torsional buckling. Concern for end-user was given and methods are presented in a way for incorporation into governing design standards in Smith's Master's Thesis entitled "Finite strip elastic buckling solutions for thin-walled metal columns with perforation patterns" available at http://hdl.handle.net/10919/23680.
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Elastic buckling solutions for thin-walled metal columns with perforation patterns Smith, Frank Harrison (Virginia Tech, 2013-08-02)Presented are approximate finite strip methods for use in predicting elastic buckling strength of cold-formed steel columns. These methods were developed by examining elemental behavior of cross-sections in eigen-buckling ...
Consequences of Simultaneous Local and Overall Buckling in Stiffened Panels Ghosh, Biswarup (Virginia Tech, 2003-04-18)In this thesis improved expressions for elastic local plate buckling and overall panel buckling of uniaxially compressed T-stiffened panels are developed and validated with 55 ABAQUS eigenvalue buckling analyses of a wide ...
Use of Material Tailoring to Improve Axial Load Capacity of Elliptical Composite Cylinders Sun, Miao (Virginia Tech, 2006-11-16)This study focuses on the improvement of the axial buckling capacity of elliptical composite cylinders through the use of a circumferentially-varying lamination sequence. The concept of varying the lamination sequence ...


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5 Nanny Jobs Found
Need a Nanny for All day Monday's
Posted by Jeremy W. on 10/14/2016
- 8 miles away (Appleton, WI)
- $10–15/hr
- 3 children
Provide breakfast for children and transportation to school for the children. During the day watching a toddler. CPR and First Aid a HUGE plus.
Full Time Nanny needed for 2 kids
Posted by Bob D. on 10/10/2016
- 9 miles away (Neenah, WI)
- $8–12/hr
- 2 children
18 month old boy 4 year old girl (3K school Tuesday and Thursday morning) Only need Nanny for 6 months, but if things would work out awesome then that could change into very long term.
Full time child care provider
Posted by Sarah D. on 9/27/2016
- 19 miles away (Wrightstown, WI)
- $5–10/hr
- 2 children
I am looking for someone in the Wrightstown area that does in home daycare for my 16 month old son and occasional childcare for my 4 year old daughter. Must be trustworthy, reliable and have references. Thank you!!
Part Time Nanny Needed :)
Posted by Sarah P. on 9/25/2016
- 9 miles away (Neenah, WI)
- $10–12/hr
- 3 children
Hello! We are looking for a part time Nanny for our 3 children in Neenah. The hours would be roughly 16-20 hours a week. The hours of care needed would be during the day two-three days a week with afternoons and early evenings a must. (One full day of 8 hours and then two half days in the... More
A nanny to watch our daughter
Posted by Lauren P. on 9/23/2016
- 21 miles away (Omro, WI)
- $10–15/hr
- 1 child
Just someone to watch our daughter and take care of our house. While we are at work. That is all. So thanks


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City: Broken seawall water line caused $100K in damage
A broken water line on Seawall Boulevard caused as much as $100,000 damage to the street, Galveston city officials said.
A broken water line on Seawall Boulevard caused as much as $100,000 damage to the street, Galveston city officials said.
Clear Springs' Christian Waller had a solid season on the court last school year as a member of the varsity boys basketball team and is now an integral part of the secondary on the Chargers football team.
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"Some wags wondered if anyone would sue.......". Some wags evidently like to compare apples to oranges. Would these "wags" rather live next to a dorm full of marine biologists or next door to the projects?
I hope A&M Galveston expands to a 20K student university. That would be huge to the economic growth of this island.
A look at Oxford MS, home of Ole Miss (University of Mississippi). It is a town that has no industry, zero, nada, nothing. But it is booming because of the university. The town, in the 90's, had about 15K residents while the school had roughly the same amount of students. Now, both the number of students and residents has doubled. Friends say the economy is really sound and growing. Ole Miss has tons of dorms but still can't fit all the students so rental property is hot,hot,hot. My point is, we can do that here. We actually have industry, port and tourism, to help with the growth and draw of A&M Galveston. We have to overcome 2 problems, though.
1-Galveston is averse to change. 2-Galveston power brokers, power families, politicos, etc., can't stand someone else making money.
If we have the projects come back, nothing will change. Poverty pimps and their enablers will do what they have always done, and Galveston will get what it has always got. A big ole bag of squat!
If we can get the power players of Galveston, ( that's akin to being the worlds tallest midget), to get over their pubescent urinating contests and work together we can do something here! And get this, the power players can actually make money doing it as well! But they may have to swallow their pride, so I'm not too optimistic that it will happen.
I'm sorry, I'm rambling. Smell ya later
Rockstrongo's post literally made me laugh out loud. (The overused LOL doesn't really mean "laugh out loud," it just means polite laughter, a knowing smile, maybe a smirk, or maybe no reaction at all...)
Anyway, I would LOVE for A&M to expand! College kids are great for a community. A more upper attitude than most older more jaded folks, youthful drive and determination, a willingness to fill part-time or seasonal jobs, and possibly a desire to settle in the community after graduation.
Reading Heber's editorial, I couldn't help thinking that if Galveston absolutely must see a return of the projects, let's put them on Pelican Island...
It would be a dream to have a large-scale undergraduate college-aged 4 year component in Galveston, similar to Sam Houston, A&M or UT. However, I see one "negative" that would make it difficult, and that is the location of Galveston.
We are on the immediate coast. Not bad in itself, but to try to leave Galveston (to go home to spring/summer/Xmas breaks) requires the traumatic and disastrous "one road only" commute up 45/Gulf freeway and into Houston. Youngsters living in Houston have a shorter, yet still traumatic commute. The remainder of the students would have to go through Houston (even more traumatic) just to get to San Antonio, Austin, Dallas, or Beaumont.
The "draw" of having colleges/universities outside of Houston is having more of a "small town" feel. That's why it's a rite of passage to spend those golden years in Huntsville, San Marcos, et cetera. At least those kiddos are leaving a hell hole (Houston, Dallas) to a college-feel good place. Even Austin has become a trecherous Houston-type place. It's traffic is horrendous. I simply don't see college kids wanting to go through Houston to get down here from Dallas to go to classes, and try to drive out of here to visit back home.
Texas A&M in Galveston is a state Maritime Academy. It also be difficult to locate it somewhere other than the water's edge. All the other state maritime academies (Maine, Mass. NY, California, Michigan) and the US Merchant Marine Academy at Kingspoint, have bravely faced and surmounted the challenge of having a maritime school as close as possible to the sea.
It is not the result of poor planning for the future that the Colorado School of Mines is located quite near mountains...
8522 Teichman Road, Galveston, Texas 77554
7800 Emmett F. Lowry Expy., Texas City, Texas 77591
Main: 409-683-5200 | News: 409-683-5239
Circulation: 409-683-5260 | Classifieds: 409-683-5301
© Copyright 2016 Galveston Newspapers, Inc. Terms


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Compare Prenuptials attorneys near you. Read reviews, see Avvo Ratings, and contact them directly.
3.0 stars 5 reviews
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Rick was born and raised in Lakeland , Florida. He graduated from Lakeland High School and the University of Florida with a B.A. in English, and Stetson University College of Law with a J.D. degree in 1973. Upon graduation from Universtiy of F...
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When you marry, you enter a relationship contract with your spouse that entitles you as a couple to certain legal rights and responsibilities. Family lawyers specializing in marriage can write prenuptial agreements for a couple before marriage. A prenuptial agreement can be especially important if you have financial interests you've accrued earlier in life and wish to clarify how they will or won't be shared with your new spouse. A written prenuptial agreement sets out the financial expectations of your marriage and anticipates what will happen to your assets should you divorce. The process for creating an airtight prenuptial agreement can be complicated, and a lawyer with a marriage and prenuptial practice can make sure the agreement is properly written.


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Island Nights' Entertainments
Preisalarm einrichten
EUR€1.06New Kobo Germany
Auf Lager
Long stories/novellas including: The Beach at Falsea, The Bottle Imp, and The Isle of Voices According to Wikipedia: "Robert Louis (Balfour) Stevenson ( 1850 - 1894), was a Scottish novelist, poet, and travel writer, and a leading representative of Neo-romanticism in English literature. He was the man who "seemed to pick the right word up on the point of his pen, like a man playing spillikins", as G.K. Chesterton put it. He was also greatly admired by many authors, including Jorge Luis Borges, Ernest Hemingway, Rudyard Kipling, Vladimir Nabokov, and J.M. Barrie. Most modernist writers dismissed him, however, because he was popular and did not write within their definition of modernism. It is only recently that critics have begun to look beyond Stevenson's popularity and allow him a place in the canon.
|B & R Samizdat Express
|B & R Samizdat Express


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Click Image for Gallery
Show your casual instinct with this Chiffon Saree in Pink. Emblazed with Brocade and Satin Silk Lace. Comes along with an un- stitched, Pashmina blouse in Multicolour.
|Faux Chiffon
|Casual Wear
|Work Style
Shipping and handling
To India : 7 to 10 Business Days National Courier
International : 10 to 15 Business Days DHL
Return policy
Product must be returned within : 15 Days
Refund will be given as : Money Back
Shipping Cost for returns paid by : Buyer
Returns policy details : Click Here
Payment Details
Credit/Debit card and online bank transfer.


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Ali was one of my employees back in the opening days of EDL. Ali who came to us from the Resort Division through our internal CU/audition program. Ali's job was to bring to life the magic of Mary Poppins as what we called back then a "Face Character". Unfortunately, not long after the opening Ali was diagonosed with cancer and had to repatriate to her native England for treatement. This video was made by the EDL Entertainment Division, at the time under the direction of Jean-Luc Choplin, to wish Ali the best of recovery and to let her know that we, her colleagues and friends, were all thinking about her.
This last summer (2011) I had the opportunity to meet up with Ali, her husband Jeremy and their two boys as the visited Disneyland Paris for the first time (for the boys). Although confined to a wheel chair Ali was going strong and the proud mother of two beautiful children. Just wanted to share a real magical moment of memories.


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|10 Reviews
|Property type
|Minimum Stay
|0 - 7 nights
When you book through the HomeAway checkout, your booking is backed by our Book with Confidence Guarantee™ offering comprehensive payment protection.Learn more
Beachers Lodge 230 is a second floor one bedroom one bathroom oceanfront rental condo located on Crescent Beach, Florida. The home is pet friendly, and contains a wide variety of amenities to make it feel like home. There is an oven, stove, microwave, blender, small coffee maker, cookware, and more. The unit comes equipped with a telephone, a television, an ironing board, and air conditioning.
From your room, you're less than 100 steps to the ocean, with the pool in between. There are beach area showers, so you can spray off that excess sugar sand on your way back into your condo rental. There's a gated boardwalk out to the beach that you can use at any time of day or night.
Lookout to the ocean while swimming in the biggest oceanfront pool on Crescent Beach. This one bedroom condo has a fantastic view from the living room, kitchen, and private balcony. Coffee at sunrise, dolphins on the horizon, squadrons of pelicans swooping in to fish….this is why you come to the beach.
Popular local surf spot, great restaurants within walking distance, convenience store just across the street, surf station, beach police station. Boat ramp & bait shop also close by. Free Wi-Fi during your stay! Easy access to all local beaches.
Beachers Lodge 230 is a beautifully decorated, newly remodeled Beach Condo which features an ocean front heated swimming pool. Luxurious linens, tiled floors…great care and attention to detail – provides for a wonderful vacation! We pride ourselves in cleanliness and assure you an extremely clean and inviting home upon your arrival so that you may relax and enjoy your visit!
There is onsite laundry facilities, ice dispensers, soda and snack machines. Large safe parking lot. Elevators to assist in getting all that luggage up to your room.
Beachers Lodge 230
Ocean Front Vacation Rental Condo
6970 A1A South #230
Crescent Beach, Florida
Hello, I have owned and managed vacation properties for over 10 years. Previously I was a Banker for 15 years. I also owned a very successful St. Augustine home decor store!
I fell in love the awesome ocean views from the living room and balcony of the condo!
This beautifully decorated, newly remodeled Beach Condo features an Olympic sized oceanfront heated swimming pool. Luxurious linens, tiled floors...great care and attention to detail - provides for a wonderful vacation!
Thank you again Marty!! You were right: The condo was perfect! Will be back again, The Poors
We enjoyed the close beach access and had plenty of room to enjoy the day. The condo was far enough away from the tourist traps to make us feel like we had a private oasis. I would book here again!
Property is nicely decorated and ocean-front pool is terrific, however, Wifi connection was awful, (kicked us off constantly, cost us data charges!), sleeper sofa mattress is encased in noisy, thick plastic and not at all comfortable. Microwave oven door is broken. Rental office was not open on Saturday check-out, so we could not address issues in person.
We loved our stay in the St Augustine condo. The room was clean and just big enough for the two of us and our small dog. It was near two nice seafood
restaurants, one right on the beach. The beach was very dog friendly without being crowded. The description of the property was right on, and we recommend
this condo too friends and family. We loved the old town of St. Augustine and went on trolleys, carriage rides, and tours around the city. Shopping was also
fun with so many varieties of shops and restaurants. We hope to rent this condo next year if possible. The Taylor's.
This is a fantastic rental -We have stayed in this complex before in a different condo - which was a bit larger -- but didn't go back due to lack of cleanliness and the very outdated/mismatched furniture and fixtures. This condo has a beautiful beach/ocean view (I saw dolphins swimming by as I sat in the living area) with dunes right below (we had a sea turtle visitor for a few days!). This condo has lovely furniture and the decor is very fresh and up to date. The complex itself is quiet and the pool is well maintained. This is a small condo, so if you are more than 2 people and need your own space without others around - you probably won't find it here. We were there for one week. We had our 20 year old daughter visit for a few days - she was comfortable on the pull out couch and the tightness of the space didn't bother us too much. But my husband and I did decide that if we we wanted to go into a longer rental period (one or two months) we would need something a bit bigger.
We would definitely stay here again for a week. One suggestion to the owner: It would help if you could add more basic kitchen accessories -like eating and cooking utensils and large bowls for food storage (I had to store a fruit salad in a colander in the fridge).
Great little place perfect for 2 people. You couldn't get a better view in a condo of any price! Clean, with everything you need. Nice pool, and the beach was great!
This is a well kept little spot. We really enjoyed the location.. the beach was beautiful. The dog friendly beaches and location were perfect. Everyone makes you feel welcome. Everything was perfect except when it came to do laundry. There are only like 2 washers and dryers, more people than machines, we ended up going further down the road to a Laundromat which turned out to be a nice surprise, we found a great little Mexican restaurant on the way. so Win/Win for us.
The best part of Beacher���s Lodge is its location! This family friendly complex offers private access to the beach via a newly constructed wooden walkway, a nice area for grilling, and of course the sparkling Olympic sized swimming pool that is heated year round. It's a great place for all ages, with lots of convenient parking.
Beacher����s Lodge is convenient to several nice restaurants. A few within walking distance to Beacher's Lodge. Try South Beach Bar & Grill on the ocean, a local favorite! If you are in a hurry just use the walk up window at Paula's Beachside Grill for lunch or snacks.
Our condos at Beacher���s Lodge are pet friendly. Your dog is welcome on our beaches and will enjoy a stroll on the sand. When nature calls a pet walk area is provided at Beacher's Lodge.
You will enjoy Beacher's Lodge 230 for a clean and comfortable stay anytime of the year! Reserve your St. Augustine getaway today. You'll be comfortable, very pleased with the view, and enchanted with the surroundings.


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Uzicopter: 80s Inspiration by Signalnoise
Uzicopter is a Tumblr dedicated to personal and downright inspiration from badass visuals from the 80s. Curated by James White from Signalnoise, it is to us a real pleasure seeing such goodness hand-picked by James. That's inspiration! Here's some of them and follow his Tumblr for more to come. Find out more about Uzicopter by Signalnoise at Uzicopter.Tumblr.com


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Classic Telephone - Trimphone in White
£35.00 includes FREE UK Postage (other delivery options available)
Shipping Destinations for this item
UK - Shipping Included
United Kingdom
Europe Zone 1 - £3.49
Austria, Belgium, Denmark, France, Germany, Ireland, Luxembourg, Netherlands, Switzerland
Europe Zone 2 - £3.49
Andorra, Croatia, Czech Republic, Finland, Liechtenstein, Monaco, Norway, Poland, Sweden
Europe Zone 3 - £4.99
Bulgaria, Cyprus, Estonia, Faroe Islands, Gibraltar, Greece, Greenland, Hungary, Iceland, Italy, Latvia, Lithuania, Malta, Montenegro, Portugal, Romania, San Marino, Serbia, Slovakia, Slovenia, Spain, Vatican City
North America - £6.99
Canada, USA
Australia and Far East Asia - £12.99
Australia, Israel, New Zealand, Taiwan
Japan - £12.99
Others - £12.99
Falkland Islands
Sorry, this product is currently unavailable.
TRIM stands for Tone Ringer Illuminated Model: it was the first phone to ring using a modern electronic warbler rather than the traditional bell mechanism. This replica version has all the style and features of the 1970s original but with modern push button dialling.
- Authentic styling.
- Push Button Dialling.
- Redial Button.
- Ringer Off/Soft/Loud Switch.
- Simply plugs into a standard socket.
For more information and our Delivery Policy see here.
For more information and our Returns Policy see here.
Catalogue No: HAG-WAW-TP022


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Thank you for viewing the award winning artwork of California artist Shannon Celia. Click PAINTINGS button above to see work and make purchases, Click EVENTS for info including current art shows. Visit Seashop to see additional paintings & vintage nautical home goods. Easily purchase prints on Fine Art America and Image Kind links here.
SUNRISE FERRIS WHEEL 6x8" Oil framed in an espresso colored wood. $600.
KEEP OFF is a 5"x5" Oil on Wood Panel
VESSEL ASSIST 5"x7" Oil on Panel


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Let's Talk Investing
Video: How to get kids excited about managing their money Add to ...
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Oh no, the event has ended. Don't miss out again, get the latest sales via our newsletter, Facebook, Twitter or RSS feed!
|12 Jan 2011 (Wed)
|21 Jan 2011 (Fri)
Straaten International is having a warehouse sale with up to 70% off from now till 31st January 2011. Items include cookers, oves, hubs, washers, dryers, vacuum cleaners and more. Brands include Bertazzoni, La Germania, Maytag and Straaten. See ad for more details.
Click on thumbnail[s] to enlarge. Sales on until 31st January 2011
Get a FREE Samsonite Black Label Richmond Spinner 75cm Luggage worth S$950 (with min S$1,000 spend within a month from card issuance) when you sign up for a HSBC Visa Platinum credit card (w/ 2-year annual fees waiver) at www.hsbc.com.sg.


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ABUJA, Nigeria — Cardinal John Onaiyekan of Abuja has called for "concrete action" to save the hundreds of girls kidnapped by Boko Haram, saying his country is "ashamed" by the failure to find them.
"Up until now, we are hearing practically nothing concrete on the issue," Cardinal Onaiyekan told Vatican Radio May 6. "I think almost every Nigerian is taken aback. We cannot explain what is happening."
"It's still more baffling that our president seems to be impotent. We have to see concrete action."
Nearly 300 girls, most of them aged between 16 and 18, were kidnapped April 14 from their boarding school in Borno, Nigeria's northeastern-most state, by members of the radical Islamist group...READ MORE


text: Cookies from the Toaster Oven 7/11/2016 9:01:00 AM My little toaster oven does a great job baking eight or 10 cookies, uses very little electricity itself, doesn't heat up the kitchen, and saves the air conditioning. The variety is endless — see some flavor ideas below. Start with the basic dough and add to it, such as for these Toasted Almond Cookies. They're buttery, tender, melt-in-your-mouth cookies. 3 Artisan Sweet Breakfast Breads 3/30/2016 11:24:00 AM Bake some delicious rustic breads — Cranberry-Pecan, Apple, and White Chocolate Apricot — and stock the freezer for special breakfasts and "high tea." All the fruits in these breads give the loaves a craggy surface that's wonderfully crunchy. These all keep for months wrapped well in the freezer. If you get them out the night before, they'll be ready to slice for breakfast, toasted or not. Delicious Gourmet-Style Chocolate Bark 2/18/2016 10:38:00 AM Chocolate bark: Possibly the most effective way to eat chocolate, short of a bar of the pure stuff. Make the Best Oatmeal Cookies 12/16/2015 10:00:00 AM My favorite, best cookie recipe just happens to actually be pretty healthy and a good choice for after-school snacks. I used to keep a tin in my office, available to anyone who hadn't had time for lunch. They have enough protein, iron and whole grain to make them guilt-free. This recipe makes about 60 two-inch cookies that freeze well. Healthy Chocolate Silk Pie with Gluten Free Macadamia Crust 9/8/2015 10:26:00 AM This is a chocolate pie unlike any others I have made. It starts with a crumb crust consisting of granola and macadamia nuts ground together, and bound with melted butter, like an extravagant graham cracker crust, only better. The filling consists of silken or extra soft tofu with over half a pound of chocolate. Is Chocolate Good for You? 7 Reasons to Eat Dark Chocolate 2/19/2015 1:07:00 PM The list of reasons why chocolate is good for you is seemingly endless. Here are just a few of the impressive health benefits of dark chocolate. How to Make Chocolate-Toffee Crackers 12/5/2014 9:29:00 AM Use saltine crackers to make a sweet and salty candy. Coated with marshmallows, chocolate, and toffee, it is the perfect treat to give or enjoy this Christmas season. Nut Butter Cups Recipe 5/12/2014 10:38:00 AM Two-ingredient nut or seed butter cups are a satisfying alternative to the typical chocolate treat. Sustainable Peanut Butter Cups 5/12/2014 9:31:00 AM Chocolate peanut butter cups make a lovely Mother's Day present. They're all the better when you can make them organically, inexpensively, and sustainably. Ricotta and Kefir 11/23/2013 11:30:00 AM In this blog we explore making your own ricotta and kefir, with recipes! Bake Sale Ideas from McCormick Kitchens 9/11/2013 3:17:00 PM Try some delicious brownie and cookie recipes from McCormick Kitchens. Holiday Fudge 12/17/2012 12:07:20 PM Christmas is just about upon us, and here's a very easy, quick and simple fudge recipe. You can embellish it any way you want with several options for fruits, nuts, and liqueurs. Your taste buds will thank you (not to mention friends and family). Easy and Delectable Chocolate Holiday Cheesecake 12/7/2012 9:25:54 AM During the holidays it is nice to have a rich, creamy, yummy cheesecake as a sophisticated dessert to share. Chocolate Turkeys and Forest Garden Details 10/31/2012 1:13:03 PM Talking about the new Chocolate Turkeys we saw on Saturday and how to properly plant into a kill mulch without doing much damage to the killing. Fair Trade Chocolate Takes the Trick Out of Trick or Treat 10/26/2012 5:02:47 PM Chocolate is often picked by child labor, slaves and trafficked people. We must find a way to address this issue and change the system for the better. Is Chocolate Really Good for You? Research Points to Yes! 10/16/2012 2:51:00 PM Recent reviews of several scientific studies support the idea that chocolate is good for your heart. A University of California/Berkeley Wellness Letter breaks down the good news on healthy chocolate. Homemade Chocolate Eclairs Recipe 4/18/2012 12:31:02 PM Homemade chocolate eclairs require a few steps but are delicious and rewarding. Chocolates of Choice: Organic, Fair Trade, and Delicious! 12/22/2011 11:23:03 AM Know a chocolate-lover? Here's info on a few of the most delicious chocolate bars, from companies that make organic, fair trade, ethically produced chocolates. Green Your Halloween 10/17/2011 1:24:25 PM Before stocking up on chocolate treats this Halloween, learn where chocolate comes from, and at what cost to the environment and cocoa farming communities. Enjoy a spooky and sustainable holiday with Rainforest Alliance's tips for a green Halloween. Chocolate and Bacon: What's Not to Love? 6/16/2011 8:07:54 AM Everyone loves a chocolate-chip muffin ... just add bacon for a special treat! Green & Black's Takes Brand's Commitment to the Dominican Republic 4/27/2011 3:45:10 PM Green & Black's, an organic chocolate company, takes a two week trip to the Dominican Republic to dig an 11.5 km trench. The trench will supply water to their cocoa farmers, helping product the cocoa which makes Green & Black's chocolate bars. White Chocolate Raspberry Jam with Coffee Liqueur 10/21/2008 2:52:03 PM Take plain old raspberry jam to the next level with the complex flavors of white chocolate and coffee liqueur.


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2-Day Sedona and Grand Canyon Tour From Phoenix (Product Code: 14-64456)**With Grand Canyon Railway**
Summary of The Day: Departing from Phoenix, we'll travel through the Sonoran Desert and on to the magical Red Rocks of Sedona. After your first panoramic overlook, the rest of the afternoon will be yours to hike one of the many trails. Or join us for an optional jeep tour of the seductive backcountry (own expense).
Summary of The Day: Continue your Colorado Plateau ascent on the Grand Canyon Railway, taking you back in time to the days of the Wild West, weaving through the Ponderosa pine forests and alpine tundra, gradually climbing to an elevation 7,000 feet above sea level. You will be given ample time to walk to all the lookout points and browse the local gift shops.
*Price for single occupancy applies when one person stays in one standard hotel room.
*Price for double, triple, and quad occupancy applies when two, three, and four people stay in one standard hotel room, respectively.
*Triple and quad price does not guarantee a third or fourth bed in the room, but may be requested at check-in.
*Price for child applies when a 2-15 year-old stays in one standard room as a third or fourth person.
*Maximum room capacity: 4 people including adults and children/infants.
Ground transportation in brand new maxi-van
Ticket on Grand Canyon Railway from Williams, AZ, to Grand Canyon National Park
Entrance to Grand Canyon National Park
1-night hotel accommodations in Sedona
Professional tour guide
All personal expenses, additional hotel service, and meals
Optional Jeep Tour
Customary gratuities
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Yes, the ticket to Grand Canyon Railway is included in the tour pricing.
Thank you for your inquiry. Please reply to this email or call us at 1-866-933-7368 (US&Canada), 1-626-389-8668 (International) (24 hours a day, 7 days a week) if you have further questions.
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Use of this website constitutes acceptance of the Tours4fun Terms and Conditions. CST # 2096846-40


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social language learning
need a developer who can create an easy community platform. people who want to learn another language but have nobody to contact for practicing the language. on this website they can find others with whom they can speak.
Ingin menghasilkan uang?
- Atur anggaran dan kerangka waktu Anda
- Uraikan proposal Anda
- Dibayar untuk pekerjaan Anda
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narendragautamGwalior, India
About Me: Expert in Web, Android and Windows Application Development. more than 10+ year in software development. Service Description: I work by myself, I will be available during Monday to Saturday. I always keep in touch with my client every day. my response time for email is less than 1 hours. mostly i am on-line at Gmail on Android Smartphone for prompt response ( like a chat ). Programming Language and frameworks:, C#, MVC, PHP, Android JAVA, Advance JavaScript and Ajax, Eclipse, MySQL, MSSQL, SQLite, Ruby on Rails,, MVVM, Knockoutjs, Angularjs, nodejs, JIRA, Test complete 10, AWS , Github, SVN MSDN, Visual Studio 2015
concettolabsAhmedabad, India
PHP | Wordpress | Laravel | AngularJS Android | iOS | IONIC | REST API | Materialize CSS I hold a Bachelors in Computer Science, a Masters in software engineering and am PMP certified. We are a dedicated team of 20+ highly skilled IT professionals with a combined experience of more than 6 years. I am super experienced web programmer who has successfully launched various huge projects and has proven my skill in many opportunity. My Vision : High Quality, Speed, Satisfaction with each point ! - Area of Expertise > WordPress, Laravel, AngularJS, HTML5, CSS3, JQuery, > Android, REST API > eCommerce Platform - Magento, Shopify, Prestashop > Apache, Social Network APIs and much more. > Major PHP Frameworks - Laravel (Extensively Using) - Cake PHP - YII Database (MySQL, MongoDB, MsSQL, Oracle, PostgreSQL) - I provide well structured, high quality code with error free guarantee. Thanks a million.
usmanmirza9Karachi, Pakistan
We are a vastly experienced unit of assorted expertise, having a full house of extraordinarily skilled and incredibly amusing individuals. Every single person at Techventor is madly in love with not only the work we do but also with the place we work at. Over the years since we have marked our place in the market, it wasn't so easy to make a distinct name in the overly populated industry, but our vision of providing qualitative services and goal to keep customer satisfaction on top, allowed us to make a long run relationships with our valued clients and make them glad to do business with us persistently. Having a firm grip on our abilities, we are proficient in offering; Game Development & Illustration, UI/UX Designing & E-commerce Solutions, 2D & 3D Animation and Graphic Designing. Believing in the idea of spreading roots as much as possible Projects Completed: Web: 134 Games: 25 Animation: 67 Graphic Designing: More then 200 Logo design 150+ Portfolio www.techventor.com
satyaowlokindore, India
Thanks for viewing my profile. I will provide you the best and comfortable service, My objective is achievement of your goals and that's why on the final stage of project you will receive exactly what you need! I offer a range of Web Design, Web Development,Graphic Design, UI Design, Video Editing, 3D Animation work for my clients. I work hard to provide clients, like you, with the best quality projects. It doesn't matter if you hire me for a small graphic design job or a large e-commerce website I won't stop work until you're 100% happy with what I do for you. I maintain strong communication with clients at all times Web Design :- 1.Responsive Design & Development 2.Bootstrap Based Website Design 3.Parallax/One Page Web Design, 4.CMS Website & Development 5.Wordress, CI, Magento, Shopify, PHP, Joomla
dhariwal27meerut, India
The only way to represent for a developer is code. I can write best complexity code in Laravel for your web apps. I have good experience in laravel just because i had worked on large and medium scale laravel apps. Please don't hesitate to ping me and hire for laravel jobs. Thanks
arunsingla32Panchkula, India
Trius Infotech is a team of creative designers, professional developers and flawless QC and always ready to meet or exceed your expectations to drive your business success remotely. We have 4+ years of experience in Mobile app & website designing and development and our expertise encompasses below technologies: => Native Android and IOS app development,React app => PHP, MySQL,Javascript, jQuery, AJAX. => CMS: WordPress, Joomla, Ecommerce like Magento, Opencart, Prestashop, Woocommerce etc => PHP based frameworks i.e. codeigniter, cakephp, YII, Laravel, Zend etc. => Designing: HTML5, CSS3, Photoshop, Responsive Web/App Designs and Frameworks like Twitter Bootstrap, Less etc. => experience with XML, JSON, SOAP and 3rd party API integration Benefits of working with Trius Infotech: • 100% Quality work • Reliable for long term relationship • Fast turn around and delivery On Time • Round-the-clock support to handle queries and doubts • Affordable package for web designing & development
mituldKHAMBHALIA, India
srsinfosystemsNagpur, India
I am an experienced web developer and project manager with high goals and motivation. I have long running history of servicing clients through freelancing platforms. Since last 12 years I am providing end to end services which includes 1. Web site design 2. Web site development 3. Web site maintenance 4. Mobile application development and maintenance (Using ionic framework) Skills: Advance PHP, cakePHP, Laravel, Zend, Wordpress, Plugin development, Smarty, Jquery, Ionic, REST/SOAP API development, payment gateway integration, Social media development and plugin integrations.
afrasiyabkkkRawalpindi, Pakistan
I am a web developer and i am fond of learning new stuff in computer science. i work really hard and try my best to complete my work before time


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How Do I Know if My Dog's Toes Need to Be Trimmed?by Stephanie Mitchell
Whether dogs like it or not, they need their toenails cut regularly. Dog nails allowed to grow long may become ingrown or torn, and long dewclaws can pierce dogs' feet. Dogs with long toenails struggle to walk on slippery floors and easily damage fabric and other soft items. While you can choose to have a vet or groomer trim your dog's nails, your dog may not visit these professionals sufficiently frequently for healthy food care. A better option is to learn to recognize when it is time to do it yourself.
Look at your dog's paws while he or she is standing. If the toenails touch the floor, they need to be trimmed.
Listen as your dog walks across a hard surface. If you hear the nails clicking on the floor, they need to be cut.
Examine your dog's paws every few weeks. If the dog is very active, the nails may wear down on their own, but they also may split or tear. Trim or file damaged nails to ensure that the splits do not worsen.
Keep track of the time since your dog's last trim. A puppy needs toenails cut once a week, and older dogs need them cut once every two weeks.
Trim your dog's dewclaws at the same time as you trim the other toenails, if they were not removed when he or she was a puppy. The dewclaws are located just above the dog's paws on the inside of the legs, and they do not reach the floor, so you will never hear them clicking. Remember to cut them with the other nails.


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First Irish Corona is a 2011, 5 yr old gelding, he is as quiet and as gentle as they come! Youth suitable, Corona Cartel, First Down Dash, and Investor…SOLD
For Sale: For Sale: Gentle 17 yr old Registered AHR Haflinger mare suitable for Advanced beginner or Novice rider. Penny is a great stout little horse…SOLD
Flashy Black and White American Paint Gelding. I've had this guy for 6 years he's awesome We've covered hundreds of miles of trails with no problems. He…SOLD
This is a very cute, very stout colt. Both dam and sire are homozygous for tobiano and are 5 panel negative. This colt should mature in the 15 - 15…SOLD
Broke, broke, broke~Charlie is a gorgeous and sweet welsh/paint cross. He should be around 14 hands at maturity. Imprinted as a baby, round penned as…SOLD
Futurity winner (reined cow horse) and money earner Her sire is the world reknown Color Me Smart - APHA's first million dollar sire (and now producer…SOLD
Super safe for anyone grade 12 year old gelding. Rides out by himself or with a group. Big country walk, neck reins, just a doll to get along with. Stands…SOLD
Midnight is broke to RIDE and DRIVE! This mare is GORGEOUS! We have not had her all that long, but we've really liked her since we got her! The only reason…SOLD


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In Dilemmas (1954) Ryle analyzes propositions that appear irreconcilable, as when free will is set in opposition to the fatalistic view that future specific events are inevitable. He believed that the dilemmas posed by these seemingly contradictory propositions could be resolved only by viewing them as the result of conceptual confusion between the language of logic and the language of...


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