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|Highs & Lows
|In the News
|Insulin & Pumps
|Men's Issues
|Real Life
|Type 1
|Type 2
|Women's Issues
|Oral Meds
Keeping Track of... Us?
Categories: Highs & Lows In the News Insulin & Pumps Real Life Type 1 Type 2
Tags: food choices logging cgms accountability compliance insulin pumps glucometers keeping track of supplies
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I've recently received an invitation to join the working group for developing the IEEE P1451.1 and P1451.1.4 standards "for a Smart Transducer Interface for Sensors, Actuators, and Devices".
This is "interesting" in a number of ways not least of which is my lack of education in electrical and electronic engineering, and my very limited knowledge of radio communication. The standard, which will use eXtensible Messaging and Presence Protocol (XMPP), is supposed to be used for keeping track of, and controlling, things like inventoried office equipment, cargo containers, and smartphones; providing geographical and geospacial information to the military; and "remote health sensoring and monitoring".
It's this last bit that has me intrigued or rather, the indication that working group membership would be of interest to users and manufacturers of medical devices. Let's face it: almost every American uses at least one medical device (the bathroom scale) on a regular basis, and those of us who are members of dLife regularly use at least one additional device (glucometer), if not more (insulin pump, CGM, blood pressure monitor, etc.) Connected bathroom scales have been available to healthcare providers for a while, even if their availability to consumers has been limited to the fancy, expensive models with extensive (and largely inaccurate or superfluous) feature sets. Many of us also have upload cables for our diabetes devices, and some of us can also upload our blood pressure readings.
In a perfect world, we should be able to keep track of, upload from, and (if needed) control all of our devices from a single interface, and integrate their readings into a multiparametric data set. While manufacturer "exclusivity" plays against this, the "insulin pump hacking proof-of-concept" shows that there are security concerns that this standard must address.
Other issues I might perceive in using this standard for "outpatient" or "home" medical devices include both dose management and geolocation. Consider a centrally-controlled insulin pump with geolocation, a hypervigilant Accountable Care Organization, and the neighborhood ice cream shop. I can just see the software automatically bousing the pump for several units while emitting a loud siren warning, "Diabetic! Diabetic! Do not feed!!!" while the CGM is reading 60 with a double-down arrow...
Everything said, while I find the concept and foreseeable intended applications fascinating, I feel I don't have the expertise to contribute to the working group. I expect that like the Force, this technology will have both a dark and a light side.
I just hope it doesn't turn out to be our version of Orwell's Big Brother.
Email this
Megan was diagnosed in 2009 with Type I. As an RN, she was familiar with the medical side of her diagnosis; learning to be a good patient on the other hand, was and continues to be the challenge of her day to day life. (Read More)
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Stephen Anderson, Miller Tabak analyst explains why he maintains a "Buy" rating and $335 price target on the stock; while Jeffrey Bernstein, Barclays analyst, weighs in on his "Neutral" rating and $290 price target.
Herman Leung, Susquehanna Financial Group analyst explains why he lowered his price target on Google to $800 from $880, but still maintains a "Buy" rating on the stock.
McDonald's shares are falling after Q3 earnings missed estimates, with Matt DiFrisco, analyst at Lazard Capital Markets.
Google's earnings blunder cost the company over $20 billion in market cap. Ken Sena, Evercore Partners analyst, discusses the earnings miss, and why he maintains a "Buy" rating on the stock, and $860 price target.
Geoff Lewis, Global Market Strategist, J.P. Morgan Asset Management says that fixed investment is on the uptrend in Southeast Asia, and discusses what this means for investors.
How to trade Google post earnings, with Colin Gillis, BGC Financial Partners. Gillis has a "hold" rating on the tech giant, with a $690 price target.
The company said it plans to lay off 15 percent of its staff as part of a broader restructuring plan after reporting a worse-than-expected net loss.
Google's Q3 2012 earnings conference call, with CEO Larry Page, CFO and Senior Vice President Patrick Pichette, Senior Vice President and Chief Business Officer Nikesh Arora; and Investor Relations director Jane Penner.
Colin Gillis, BGC Partners analyst, weighs in on the decline of Google shares.
Ken Sena, Evercore analyst, explains why he has an "equal Wweight" rating on the stock and a $54 price target.
David Hilder, Drexel Hamilton banking analyst, breaks down the company's third quarter numbers of $0.28 EPS on $7.6 billion in revenues, and discusses whether to invest in financials now.
Benjamin Schachter, Macquarie Securities analyst, provides a preview of the tech giant's third quarter numbers, and explains why he maintains a $725 price target on the stock.
Larry Fink, chairman & CEO of BlackRock, shares his view on Vikram Pandit's resignation, the fiscal cliff and the economy.
Where the markets are headed next, with Eric Mintz, Eagle Asset Management, and Paul Hickey, Bespoke Investment Group.
The FMHR traders reveal their final trades.
The FMHR traders reveal their top three trades. Meanwhile Jim O'Neill, Goldman Sachs Asset Management, says there are plenty of ways to get returns going forward.
Shaw Wu, Sterne Agee analyst, discusses the worries that are weighing on "Big Blue", and explains why he has a "buy" rating on the stock and $230 price target.
Gene Munster, Piper Jaffray analyst, discusses just how big an impact the smaller iPad will have on Apple.
Doug Freedman, RBC Capital Markets analyst, breaks down the tech giants third quarter results, and explains why he downgraded the company to "market perform" and has a $24 price target on the stock.
Joseph Foresi, Janney Montgomery Scott analyst, explains why he has a "neutral" rating on "Big Blue" and a $211 price target.
E. Paul Rowady, Jr., TABB Group senior analyst, discusses the buzz over a new high frequency trading tactic called "banging the beehive," which could be impacting the way natural gas futures are traded.
Institutional Investor unveiled its All-America Research Team this morning, ranking Deutsche Bank's Charles Grom among the nation's top analysts. Grom joins the Fast Money traders to discuss the market's top retail performers over the past year.
The retail names that have performed well look to do well through year-end, says Charles Grom of Deutsche Bank.
Jim Iuorio, TJM Institutional Services, takes a look at the latest analyst calls.
The FMHR traders reveal their top three trades. And Wilbur Ross, WL Ross & Co., weighs in on Vikram Pandit's exit from Citigroup.
"Changes at the top always involve risk," said David Trone, JMP Securities, weighing in on the impact of Pandit's departure on the company's stock.
Jeffery Harte, Sandler O'Neill principal, discuss the quick departure of Citi's CEO, and why he believe Michael Corbat is a good fit to replace Vikram Pandit.
Douglas Sipkin, Susquehanna Financial senior analyst, breaks down the big bank's third quarter earnings of $2.85 versus $2.12 estimates, on revenues of $8.35 billion.
David Silver, Wall Street Strategies analyst, breaks down the quarterly results of Dow component, Coca-Cola.
Sanjay Sakhrani, Keefe, Bruyette, & Woods senior analyst, offers his top stock picks, and discusses where he sees solid trends in the market.

subset: commoncrawl


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ALDERLANE COTTAGE, family friendly, character holiday cottage, with a garden in Wexford Town, County Wexford, Ref 4410
From $257 / week
Description from the manager
Description from the manager
Bedrooms: 3/
Bathrooms: 1/
Sleeps: 4/
Type: House
Book this 3 bedroom, 1 bathroom house in Wexford today! A total of 4 people can sleep here comfortably.
No travelers have shared a review of this property yet.
Costs vary, with the average weekly rate as low as $210.00 to as high as $470.00, depending on travel dates.
The owner responds to 100% of inquiries and last updated the property's calendar today.
About the manager
About the manager
Sykes Cottages
Sykes Cottages
- Response rate: 100%
- Response time: A few hours
- Calendar updated: today
Overall rating:
4.7 / 5.0
Proximity to TripAdvisor's Top Wexford Attractions
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Live Prices Not Available
To show you the most accurate prices, TTPM only displays our pricing tool on products which we've reviewed in the past three years.
MVP Sky Igniters are durable foam planes with cool graphics and a flashing LED light. The MVP stands for "maximum velocity planes" because these planes can fly up to 20 feet. The Sky Igniters are easy to launch. Press the button to turn on the LED light. Then attach the flight stick to the bottom of the plane. Pull your arm back and then fling the stick forward to launch the Sky Igniter. The Sky Igniters come in three styles. Each is sold separately.
The MVP Sky Igniters offer great basic play that kids will want to do again and again. With the LED lights, the Sky Igniters are fun to fly in the day or at night.
The MVP Sky Igniters are for ages 5 and up.
Two button cell batteries are included.
2 Cell batteries required
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Is it just us, or do all the Face 4 Music models have one thing in common? A hot mum!
First we noticed how hot Maya Jama's mum is (we actually thought she was her elder sister), and now fellow model Nakiya Milan has shown the world where she gets her good looks from by tweeting a photo of her mother.
Woah there!
The model tweeted the photo wishing her mother a happy birthday, and get this – she's apparently 41!
Someone's clearing been guzzling from the fountain of youth.


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Legia Warsaw fans are not happy with UEFA and they have a fiery way of showing it.
UEFA fined the Polish club and ordered the team to close off the...
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Tall Boots
Steve Madden Pull-On Tall Boots | South Moon Under
All The Way Up Taupe Suede Tall Boot More
Nordstrom Anniversary Sale outfit - white tee + olive cardigan + tall boots + dark wash jeans, perfect fall outfit!
#fall #fashion / monochrome
Pinterest: taylor_kagel
Love the style but only buy faux suede or leather...do not support the abuse and slaughter of animals for our pleasure.
#anthrofave: October New Arrival Shoes & Boots
6 Ways To Get Ready To Start Working For Yourself In 2016 More
Sweater tunic & tall boots
Ankle boots were a popular fashion item last fall but now it's over-the-knee boots that will be on top of your shopping list. Wear them with jeans, black tights, or a dress. You will turn heads everywhere you go, guaranteed. - See more at: http://www.quinceanera.com/look-your-best/fall-fashion-trends-to-wear-now/#sthash.r0SGIdIZ.dpuf


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New Member Promotion >>> Save $15 and get a SHRM tote!
Giving applicants with criminal backgrounds a fair chance at employment can be good for business.
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Apply for the SHRM Certification Exam and begin advancing your career.
Learn how to make the business case for diversity, October 25-27.
U.S. employers announced 18 percent fewer layoffs in February 2016 after January's six-month high, according to the monthly job cuts report by global outplacement consultancy Challenger, Gray & Christmas.
The Chicago-based firm reported that employers downsized 61,599 jobs during the month, down from 75,114 in January.
The February 2016 total was up 22 percent from a year ago, however, and layoffs have totaled 136,713 through the first two months of 2016, up 32 percent from the same period in 2015, when employers announced layoffs totaling 103,620 in January and February.
The energy sector continues to feel the brunt of low oil prices. Energy firms announced another 25,051 job cuts in February 2016, bringing the year-to-date total to 45,154, a 24 percent increase from 2015.
"Since January of 2015, [the energy and industrial goods sectors] alone have seen workforce reductions in excess of 200,000, the majority of which were attributed to oil prices," said John A. Challenger, chief executive officer of Challenger, Gray & Christmas. "Shockingly, we have not seen a precipitous rise in unemployment in the many cities that were benefitting from the recent oil boom, suggesting that the job losses are contained to the energy sector, for the moment."
Unemployment rates have increased in energy-centric metropolitan areas, but most are still below the national average of 4.9 percent, Challenger said. For example, Houston's jobless rate increased from 4.0 percent in December 2014 to 4.6 percent in December 2015, according to the U.S. Bureau of Labor Statistics. The unemployment rate for Midland, Texas is 3.3 percent and Bismarck, N.D., is still enjoying an unemployment rate of 2.7 percent.
The technology sector is also experiencing a wave of job cuts. Tech companies have announced 16,006 layoffs so far in 2016, a 143 percent increase from the 6,582 job cuts recorded in the first two months of 2015.
"There will always be heavy churn in the tech sector," Challenger said. "It is an area that embodies change, trial and error, and constant reinvention. Even among the more established firms in the industry, we see workforce volatility, as they branch into new products or services, some of which may or may not succeed."
Year-to-date, the retail (23,342), industrial goods (7,069) and chemical (6,790) industries round out the top five for planned layoffs. Texas leads in layoffs year-to-date (52,205), followed by Arkansas (16,100), California (10,100), Ohio (6,672) and Iowa (6,560).
Roy Maurer is an online editor/manager for SHRM.
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Our Trainers
Adriana Medina, Owner Fuerte Fitness
Education: B.A. in Business Administration (International Business) from Boise State University. Certified by the International Sports and Science Association (ISSA) and the National Academy of Sports Medicine (NASM).
Personal Training Experience: In the fitness industry for 15 years. Trained individuals during most stages of life; from rehabbing an injury, fitness competitions, to motherhood and many others. Extensive experience working in areas of fat loss, muscle gain, and functional health. Enjoys working in pre- and post-natal training, sports-specific athletic training, core strength, and flexibility.
Activities:IFBB North American Figure Competitions, PA. 2013, Relays in Pacific Northwest/Zion. Most recently: New mom.


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LipoCell® contains concentrated high potency fish oil derived from sardines and anchovies, flavoured with natural fruit oils and extracts. LipoCell® is a liquid preparation containing high levels of DHA and EPA. The recommended intake is two teaspoons (approx 10ml) taken daily with food, or as professionally directed. For children between 2-5 years, half a teaspoon, and for children 5 years and over, one teaspoon daily or as professionally directed. Can be mixed into water or juice, or taken directly from the spoon. This intake provides 2.95g of Fish Oil, 50mg of Vitamin C and 25mg of Natural Mixed Tocopherols.
LipoCell Supplement ingredients: Concentrated Pineapple Juice, Fish Oil Concentrate1, Modified Corn Starch, Water, Fructose,, Concentrated Orange Juice, Mango Purée, Banana Purée, Alginate, Vitamin C (as Ascorbic Acid),, Pineapple Flavour, Prebiotic Acacia Gum, Vanilla Flavour, Antioxidant (Ascorbic Acid & Natural Mixed, Tocopherols2), Sunflower Oil, Preservative (Potassium Sorbate), Citric Acid.
We save your basket until you place an order for your convenience.
If you have any feedback about how we could improve our website or service please click here and let us know.


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Ume.net Viral Video: Living With Lag
Ume.net – a Swedish broadband provider – has arranged an experiment, which has gone viral.
The most annoying thing that can happen to an internet user is a lag. Why would anyone tolerate that? Imagine that your senses would lag in a real life. The creatives have made Oculus Rift, which demonstrate exactly that. See how people fail to perform the easiest daily tasks with only a 3 seconds delay. That is hysterical!
Watch the video and have a good laugh.
Client: Ume.net


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Hey, I'm Jenn, and I write dead bodies for ages 13 to six-feet under.
While you're here, take a look around and don't forget to sign up for my newsletter so you won't miss out on all the wonderful books, giveaways, and other news!
Happy Reading!
August 29, 2016
Gianna Mancini mystery #3 is available for preorder now!
CUPCAKES, BUTTERFLIES & DEAD GUYS will released on November 8, 2016. Aunt Stella (from CHRISTMAS, SPIES & DEAD GUYS) is back, along with Freezer Dude, and Gianna's favorite movie star, Raina Stone. Possible murder, a wedding shower, and a new job await Gianna on her latest adventure.


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All Entries Tagged With: "coaster"
Kickstand envy? Get a Smartphone Coaster from NewPCgadgets
Posted by Press Releases | Dec 27, 2010 | 0
Having an easy way to hold the phone so it can be viewed is simply great, and is one of those things you wonder how you ever got along without. Fear not, non-kickstand enabled smartphones, the latest product from newPCgadgets called "Smartphone Coasters" has you covered. iPhone Coasters are designed to hold your iPhones or iPod touch at a comfortable 60 degree viewing angle. The sleek and attractive stainless steel Coasters have already become newPCgadgets biggest seller.
Be Trendy – Offer guests a Smartphone Coaster
Posted by Press Releases | Oct 11, 2010 | 0
newPCgadgets has just introduced a new stainless steel coaster that provides the ultimate convenience stand for Smartphones. Smartphone Coasters are stainless steel stands that are space-saving and stackable. Perfect for home or business, Smartphone Coasters provide friends, guests or customers fast access to their Smartphones. Professionals attending a business lunch or dinner will love the ability to view text messages and incoming calls faster.


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Free personalized radio that
plays the music you love
Cuando Volveras
Features of This Trackmajor key tonality
simple harmonic progressions
heartbreak lyrics
Latin pop roots
afro-latin influences
electric piano playing
ambient synthesizers
hand drums
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
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Considered by most to be the Cardinals' top prospect, Reyes will be making his major league debut. He has made 19 starts for Triple-A Memphis this season, going 7-4 with a 3.44 ERA, allowing 88 hits, striking out 106 and walking 28 in 104-2/3 innings. Opponents are batting only .219 against him and he was recently tabbed in Baseball America's Best Tools survey as having the best control in the Pacific Coast League.
The 23-year-old right-hander was placed on the disabled list on June 14 and missed 19 days with a sprained AC (acromioclavicular) joint in his right shoulder, but is said to be fully recovered now. Baseball America recently said that "Reyes has been throwing his fastball in the low 90s again since coming back from his injury, and his curveball and changeup have been solid. All that's missing is a bit of sharpness, as he knocks off a little more rust with each start."
Reyes will have to be added to the 40-man roster to be called up, but he will likely be sent back down after his start. The Cardinals just need someone to make a spot-start so they can give the starting rotation an extra day of rest since the Cardinals have only one scheduled off-day during the entire month of August.
"We're thinking about how we're going to deal with these 30 games in 31 days" this month, manager Tony La Russa told the St. Louis Post-Dispatch for Monday's edition. "That (schedule) goes against what we're been trying to do - to periodically get our pitchers an extra day. We've been rolling over our rotation all year long, so whenever there's an off day, guys can pitch on their sixth day so that when we get into this part of August, we've got a lot of guys feeling good.
"But, with our schedule in August, we can only do that one time. So, we've been thinking of ways we can create that, and all we can do is add a starter."
Last season was Reyes' first as a pro. Reyes pitched with Chicago Cubs' ace Mark Prior in college at Southern California and remains good friends with him. Nagging elbow injuries caused him to fall in both the 2002 and 2003 drafts. He was drafted in the 13th round by Detroit in 2002, but did not sign. He did, however, sign with the Cardinals in 2003 after they took him in the 15th round, but he would not begin his professional career until 2004.
Reyes made the opening day start for high Class A Palm Beach last season, but he would make only one more start after that before going on the disabled list for two months with shoulder tendonitis. He made five more starts after coming off the disabled list before being promoted to Double-A Tennessee on July 1. From that point on, Reyes was dominant. In 12 starts for the Smokies, he went 6-2 with a 2.91 ERA, striking out 102 and walking only 13 in 74-1/3 innings while opponents hit only .230 against him.
Jason Scott can be reached at firstname.lastname@example.com


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Product Description
Event Schedule
Tuesday May 23rd - 10:00am-5:00pm
Wednesday May 24th - 10:00am-5:00pm
Thursday May 25th - 10:00am-4:00pm
Building on the drawings and works created in the 3 Day Find Your Artistic Voice workshop, participants will use their initial pieces to create a visually unified mini series of encaustic works pushing their central idea or concept through further additions of marks and lines, colour, textural and metallic effects, incising, attaching 3D objects and other encaustic and mixed media techniques and processes. Once again this class will teach you technical and conceptual strategies that will take your image making and overall artistic practice to a deeper and more meaningful level.
To see some of Nancy's encaustic work visit her at www.nancycrawfordartist.com
Workshops Policies : Half-day, full-day, multi-day workshops, and special events are scheduled throughout the year. Once you purchase a workshop you will be enrolled.
Due to limited class size, purchased spots for all workshops are transferable but payment is non-refundable. What this means: If you buy a class spot and are unable to attend, and if there is a waiting list of students that has formed, we will put you in contact with the first person on the list to whom you can offer your class spot. If the person on the list accepts, then that person will need to pay you for your spot and once that transaction is complete and both parties are satisfied, we will transfer your spot to the other person. If you are unable to attend and there is no waiting list, we will unfortunately be unable to provide refunds.
Emergency Cancelations : In the very rare event of an emergency or unavoidable natural disaster or act of God, the class may be cancelled. In this situation, all fees will be reimbursed to students in full.If you would like to enroll in a workshop that has been sold out, please send an email to email@example.com and you will be put on a waiting list.
Questions? Contact email@example.com
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From the Department of Medicine (Drs Kropski, Polosukhin, Lawson, Blackwell, and Loyd and Mss Mitchell and Markin), Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine; Department of Veterans Affairs Medical Center (Drs Lawson and Blackwell); and the Division of Medical Genetics and Genomic Medicine (Drs Phillips and Cogan), Department of Pediatrics, Department of Pathology, Microbiology and Immunology (Drs Johnson and Phillips), Department of Cancer Biology (Dr Blackwell), Department of Cell and Developmental Biology (Dr Blackwell), and Department of Biostatistics (Dr Choi), Vanderbilt University School of Medicine, Nashville, TN.
Correspondence to: Jonathan A. Kropski, MD, 1161 21st Ave S, T-1218 Medical Center N, Vanderbilt University Medical Center, Nashville, TN 37232; e-mail: email@example.com
Some of these results have been presented previously in abstract form (Kropski JA, Mitchell DB, Markin C, et al. Am J Crit Care Med. 2013;187:A1081).
Funding/Support: The study was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute [Grants HL92870, HL085317, and HL094296 to Dr Blackwell and Grant HL105479 to Dr Lawson] and the Department of Veterans Affairs (grants to Drs Lawson and Blackwell).
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.
Short telomeres are frequently identified in patients with idiopathic pulmonary fibrosis (IPF) and its inherited form, familial interstitial pneumonia (FIP). We identified a kindred with FIP with short telomeres who did not carry a mutation in known FIP genes TERT or hTR. We performed targeted sequencing of other telomere-related genes to identify the genetic basis of FIP in this kindred. The proband was a 69 year-old man with dyspnea, restrictive pulmonary function test results, and reticular changes on high-resolution CT scan. An older male sibling had died from IPF. The proband had markedly shortened telomeres in peripheral blood and undetectably short telomeres in alveolar epithelial cells. Polymerase chain reaction-based sequencing of NOP10, TINF2, NHP2, and DKC1 revealed that both affected siblings shared a novel A to G 1213 transition in DKC1 near the hTR binding domain that is predicted to encode a Thr405Ala amino acid substitution. hTR levels were decreased out of proportion to DKC1 expression in the T405A DKC1 proband, suggesting this mutation destabilizes hTR and impairs telomerase function. This DKC1 variant represents the third telomere-related gene identified as a genetic cause of FIP. Further investigation into the mechanism by which dyskerin contributes to the development of lung fibrosis is warranted.
Idiopathic pulmonary fibrosis (IPF) is a progressive and frequently fatal lung disease with no known effective treatment. While early reports suggested inherited forms of IPF were rare, several more recent studies suggest ≥ 20% of IPF is heritable1-3; this syndrome has been termed familial interstitial pneumonia (FIP).4 To date, four genes have been linked to FIP: two components of the telomerase complex, TERT and hTR5,6; the RNA component of telomerase; and two surfactant proteins (surfactant protein C7-9 and surfactant protein-A2).10TERT mutations are the most common identified genetic cause of FIP, representing 10% to 15% of FIP families; nonetheless, in > 80% of FIP kindreds, the gene responsible remains unknown.11 Interestingly, up to one-third of patients with IPF have short telomeres in peripheral blood mononuclear cells (PBMCs) in the absence of a known mutation in TERT or hTR,12,13 suggesting other mechanisms may link telomerase function to the pathogenesis of IPF.
Mutations in TERT, hTR, and other components of the telomerase complex were first identified in families with dyskeratosis congenita (DC), a syndrome characterized by skin hyperpigmentation, nail dystrophy, oral leukoplakia, and asplastic anemia.14 Lung disease, cirrhosis, and other bone marrow dyscrasias (including macrocytic anemias, myelodysplastic syndrome, and acute myeloid leukemia) also occur in some kindreds with DC.15 We and others have recognized kindreds with FIP who share some features of DC but do not carry mutations in TERT or hTR. In this study, we screened affected family members from one such kindred with FIP for mutations in other telomere-related genes and identified a novel missense mutation in dyskerin (DKC1).
The Vanderbilt University institutional review board approved this investigation (#020343), and subjects or their surrogates provided written informed consent prior to enrollment in the study. The proband was identified from the Vanderbilt Familial Interstitial Pneumonia Registry and underwent a clinical evaluation including high-resolution CT (HRCT) scan, pulmonary function tests (PFTs), and bronchoscopy with transbronchial biopsies. A pedigree was constructed using Progeny (Progengy Software LLC). Clinical records of affected members were obtained and reviewed for research purposes. Hematoxylin and eosin-stained slides from paraffin-embedded lung tissue from biopsy specimens were reviewed by an expert lung pathologist.
DNA was isolated from blood and paraffin-embedded lung tissue using a PureGene Kit (Gentra Systems Inc). Control DNA was obtained from married-in subjects from other kindreds in the FIP registry. Lymphoblastoid cell lines were generated by Epstein-Barr virus transformation of lymphocytes from the proband, other members of the kindred, and healthy control subjects (n = 5), as previously described.16 RNA was isolated from lymphoblastoids using a Qiagen RNAEasy Mini Kit (Qiagen NV).
Modified Sanger sequencing of DNA from the proband was performed for NOP10, TINF2, NHP2, and DKC1 by a Clinical Laboratory Improvements Amendment-approved laboratory. Confirmatory sequencing of DNA samples for the DKC1 Thr405Ala mutation was performed by polymerase chain reaction (PCR) amplification of the specific region of exon 12. The primer sequences used were forward 5′-TTCTGGACAAGCATGGGAAG-3′ and reverse 5′-CAGCAAGTGTGCCGTCTCTA-3′. The PCR used Platinum TAQ polymerase (Thermo Fisher Scientific Inc) with cycling conditions of 94°C for 3 min for denaturation, followed by 60 cycles of 94°C for 30 s, 62°C for 30 s, and 68°C for 30 s, and a final extension of 68°C for 3 min. This yielded a 122 base pair product, which was visualized on a 2% agarose, ethidium bromide gel. Each amplification product was treated with ExoSAP-IT (USB Corp) prior to sequencing. Sequencing reactions were performed using the reverse primer listed and BigDye Terminator Version 3.1 Sequencing Kit (Thermo Fisher Scientific Inc) according to manufacturer's protocol. Products were analyzed by capillary electrophoresis using an ABI Prism 3100 Genetic Analyzer (Thermo Fisher Scientific Inc).
Telomere restriction fragment (TRF) analysis was performed using the Southern blotting technique. Peripheral blood-derived genomic DNA (1 μg) was processed according to the instructions found in the TeloTAGGG Telomere Length Assay Kit (Roche Diagnostics Corp). Blots were exposed to radiographic film and imaged using the AlphaImager FC (Cell Biosciences Inc) and quantified with AlphaVIEW SA software (Cell Biosciences Inc). TRF length was calculated as described in the TeloTAGGG kit protocol.
Telomere length in type 2 alveolar epithelial cells (AECs) was measured by fluoroscence in situ hydridization using Cy3 tag as previously described.12,17 Sporadic IPF lung tissue was obtained from our tissue repository of well-phenotyped patients with IPF (n = 7). Normal control lung tissue was obtained from donor lungs rejected for transplant (n = 8). Identification of type 2 AECs was performed by costaining with rabbit antihuman prosurfactant protein C primary antibody (Merck KGaA) and fluorescein isothiocyanate antirabbit secondary antibody (Jackson ImmunoResearch Laboratories Inc). Ten images were performed for each slide with fixed digital camera settings using × 630 magnification, and all fluorescein isothiocyanate-positive type 2 AECs were analyzed. Specifically, each nucleus was marked, and fluorescent intensities were measured for both Cy3 (telomere-specific signal) and 4′,6-diamidino-2-phenylindole (general DNA content) separately using Image-ProPlus 7.0 software (Media Cybernetics Inc). Then, telomere length was calculated as a ratio of red fluorescent intensity to the blue fluorescent intensity.
Sorting intolerant from tolerant (SIFT) analysis,18 which uses changes in amino acid sequence to determine whether a mutation is likely to be deleterious, was performed. A SIFT score < 0.05 is considered likely to deleteriously affect function.
DKC1 and hTR expression were measured by quantitative PCR (qPCR) using RNA isolated from lymphoblastoids. Data are expressed as copies relative to β-actin expression. The following primer sequences were used: DKC1: (F) 5′-CTCGGAAGTGGGGTTTAGGT-3′ (R) 5′-TCTTCTTTTCCTTCTTGATCAACTG-3′19; hTR: (F) 5′-GGAAGCTTGCTAGCGCACCGGGTTGCGGAGG-3′ (R) 5′-GTTTGCTCTAGAATGAACGGTGGAAG-3′; β-actin: (F) 5′-GAAGCATTTGCGGTGGACGAT-3′ (R) 5′-CGAGGTCATCACCATTGGCAA-3′.
A linear regression analysis of TRF on age was performed using data from normal control subjects, and prediction lines for new data with several significant levels were obtained from the regression. The TRF for affected proband, carrier daughters, and unaffected maternal aunt were plotted against their age on top of the prediction lines to present their percentiles in the prediction. Differences among groups were assessed using one-way analysis of variance and between groups using a two-sample t test. Results are presented as mean ± SD. The programming language R version 2.15.220 (R Project for Statistical Computing) and GraphPad Prism, version 5.0 (GraphPad Software Inc) were used to make plots and to perform the statistical analyses.
A 69-year-old man with diabetes, hypertension, hyperlipidemia, and prior tobacco use presented with 2 years of progressive dyspnea and cough. He had worked as an electrician and had no notable exposure history. His brother had recently died of IPF. His physical examination was notable for an oxygen saturation of 91% on room air, bibasilar crackles, and a hyperpigmented rash on the trunk with an erythematous, dyskeratotic rash on the palmar and dorsal surfaces of both hands (Fig 1A). Laboratory studies were notable for a macrocytic anemia. Connective tissue disease serologies, including anti-Jo1 antibodies, were negative. PFTs revealed moderate restriction with a severely reduced diffusing capacity. A HRCT scan of the chest showed bilateral reticular changes with mild bronchiectasis and rare ground-glass opacities consistent with idiopathic interstitial lung disease (ILD) (Fig 1B). Transbronchial biopsy specimens demonstrated interstitial fibrosis (Fig 1C). Review of a surgical lung biopsy specimen of the affected brother confirmed changes consistent with usual interstitial pneumonia (Fig 1D). A pedigree for this kindred was constructed, which was consistent with an autosomal dominant or X-linked inheritance pattern (Fig 2).
In this kindred, two brothers presented with ILD accompanied by skin rash, macrocytosis, and nail changes. Since some features of DC, including bone marrow abnormalities and skin changes, have been identified in individuals from FIP families possessing telomere-related mutations, we evaluated telomere length in PBMCs from this kindred. Using PBMCs from the proband and multiple first-degree relatives, we measured telomere length and found that the proband had markedly shortened telomeres (below first percentile for age) (Figs 3A, 3B); two of three offspring of the proband also had short telomeres (below 10th percentile for age).
With the confirmation of FIP and short telomeres, we began to search for mutations in telomere-related genes. We first sequenced the proband for mutations in TERT and hTR but did not detect a mutation. We then performed targeted sequencing of additional telomerase related genes TINF2, NHP2, NOP10, and DKC1. No mutations were detected in TINF2, NHP2, or NOP10; however, a previously undescribed A-to-G 1213 transition that is predicted to encode a Thr405Ala amino acid substitution was identified in DKC1 (Fig 4). SIFT analysis, which uses an algorithm using the amino acid sequence to predict whether a mutation is likely to significantly affect function, predicted this to be a deleterious mutation (SIFT score, 0.02). Confirmatory sequencing of the affected sibling's DNA identified the same Thr405Ala mutation. As DKC1 lies on the X chromosome, each of the female offspring is an obligate carrier of the variant. To prove transmission of this variant, we sequenced DKC1 in each daughter and confirmed heterozygosity for the same Thr405Ala mutation; a maternal aunt with normal length telomeres did not carry this variant.
Having identified this novel Thr405Ala substitution in DKC1 in the affected subjects, we next sought to characterize its functional consequences. Since the proband had markedly shortened telomeres in peripheral blood, we sought to determine if short telomeres were also found within the lung. We measured relative telomere length in type 2 AECs from lung biopsy specimens from the proband, affected sibling, normal control lungs, and sporadic IPF cases, using a dual-fluorescence approach with fluorescence in situ hydridization (for telomere length) and fluorescence immunostaining for prosurfactant protein C (to identify type 2 AECs). Sporadic IPF lungs had shorter AEC telomeres than control lungs; however, both the affected subjects had telomeres that were below the detection threshold in this assay (Figs 3C-E).
Next, we used an in vitro approach to analyze the effect of this Thr405Ala DKC1 substitution on mRNA expression and DKC1 function. We isolated RNA from lymphoblastoid cell lines generated from the proband and healthy control subjects. The DKC1 transcript level was similar between the proband and control subjects (Fig 5A), suggesting this variant does not significantly alter DKC1 expression or transcript stability. Notably, Thr405Ala lies in the RNA-binding domain of DKC1, where DKC1 binds hTR, which acts as the template for TERT in the active telomerase complex. Mutations in this region have been reported to decrease hTR stabilization in children with DC.21 We found that hTR level was markedly decreased in lymphoblastoid cells from the proband compared with control lymphoblastoid cells (Fig 5B). Additionally, whereas DKC1 and hTR levels were strongly correlated among control subjects, hTR level was decreased out of proportion to DKC1 in the proband (Fig 5C), suggesting impaired hTR stabilization caused by the Thr405Ala DKC1 variant.
In this report, we describe a kindred with FIP caused by a previously unreported Thr405Ala substitution in DKC1, a component of the telomerase complex. This mutation was associated with profound telomere shortening in peripheral blood and lung tissue from two affected brothers (Fig 2). Lymphoblastoid cells from the proband showed very low hTR levels, suggesting that the Ala405 mutation leads to impaired hTR stabilization, like previously reported DCK1 RNA binding-motif mutations. These data suggest that Thr405Ala DKC1 is a functionally deleterious mutation and, along with the observed X-linked mode of inheritance, short telomeres, and clinical findings, represents the likely genetic basis of FIP in this kindred. Identification of this mutation in a third telomere-related gene underscores the importance of better understanding the mechanisms linking telomere dysfunction to IPF/FIP. Given the frequency of telomere shortening in FIP, we expect that mutations in other telomere-related genes will be identified in FIP families in the future.
Mutations in DKC1 have been recognized as a cause of X-linked DC22; however, these mutations typically present with aplastic anemia early in childhood and those affected rarely survive to adulthood.23 Most disease-causing DKC1 mutations cluster near the N-terminus or near the hTR binding/pseudourine synthase domain; the Thr405Ala substitution that we describe maps to the latter. While pulmonary disease occurs in about 20% of childhood DC cases,15 we are not aware of studies reporting the prevalence of ILD specifically in adults carrying DKC1 mutations. This is likely because severe mutations often lead to other life-limiting complications early in life. Safa et al24 reported a pair of brothers aged 35 and 40 years who presented with mucocutaneous disease and who had restrictive PFTs and HRCT scan abnormalities, and Alder et al25 reported a kindred in whom an individual had pulmonary fibrosis at age 46 years. This group has previously reported another FIP with short telomeres and reduced DKC1 expression, but no coding mutations in TERT, hTR, or DKC1 were detected.26 We are not aware of other reports of a DKC1 mutation presenting late in adulthood as IPF/FIP.
The extreme telomere shortening in the type 2 AECs we observed in DKC1 mutation carriers was particularly striking; however, another important finding we observed was that all patients with IPF had short telomeres in AECs. This observation is similar to what was seen in one other report,12 suggesting that telomere shortening specifically in AECs may play a mechanistic role in the pathogenesis of IPF/FIP; further study will be needed to better clarify the mechanisms and effects of AEC telomere shortening.
The principal limitation of this study is the relatively small size of this kindred and limited number of affected individuals. Given the small numbers of affected individuals, linkage analysis is significantly underpowered to confirm "causation" with this variant. However, this variant was not present in multiple single-nucleotide polymorphism databases (dbSNP [National Center for Biotechnology Information]27 or 1000 Genomes [1000 Genomes Project]28) nor in the Exome Sequencing Project database29; thus, we are confident this represents a rare variant. Coupled with marked telomere shortening and evidence of hTR destabilization, we believe there is compelling evidence to suggest this is a deleterious mutation that represents the genetic basis of FIP in this family. The clinical phenotype in this kindred is very different from that described in other DKC1 mutations, namely that the age of presentation of any abnormalities was much later in life and with lung disease as the predominant feature. We suspect that while this variant impairs DKC1 function, the degree of impairment is less than that seen in other mutations, resulting in more severe phenotypes such as seen in classic X-linked DC30 and Hoyeraal-Hreidarsson syndrome.31
The mechanism through which DKC1 and other telomere-related genes contribute to lung fibrosis remains incompletely understood and, for a variety of reasons, animal modeling of telomere deficiency has been challenging and is of uncertain relevance to human disease.11,32,33 As a group, mutations in telomere-related genes tend to decrease telomerase activity, lead to short telomeres, and affect DNA damage responses. These changes can result in cell-cycle arrest, senescence, and apoptosis.34 How these events lead to lung fibrosis and whether other mechanisms may be involved remain areas of active investigation. Further study is required to clarify the mechanistic links between telomeres, telomerase function, and lung fibrosis.
Mutations in the telomerase pathway are the most frequently identified genetic cause of FIP. In this study, we describe a novel mutation in DKC1 that represents the likely genetic basis of FIP in a kindred with short telomeres in PBMCs and type 2 AECs in the lungs. With the identification of a third telomere-related gene associated with FIP, further study into the mechanisms linking short telomeres, telomerase function, and lung fibrosis is warranted.
Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Role of sponsors: The sponsors had no role in the design of the study, the collection of and analysis of the data, or in the preparation of the manuscript.
Other contributions:CHEST worked with the authors to ensure that the Journal policies on patient consent to report information were met.
alveolar epithelial cell
dyskeratosis congenita
familial interstitial pneumonia
high-resolution CT
interstitial lung disease
idiopathic pulmonary fibrosis
peripheral blood mononuclear cell
polymerase chain reaction
pulmonary function test
sorting intolerant from tolerant
telomere restriction fragment
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Welcome to the Katia's home page. Thank you for visit. Here you will see the beautiful model. She is ... - read more
Login or register to personalize your Models.com account and ... Model, Photographer, Stylist, Casting director, Fan. Register here » × Katia Kokoreva. Agencies ... - read more
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Home > Sunglasses > Gucci > GG 2245/S (6LB/HZ)
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West Brodway Youth Outreach is a program, in West Brodway, for children between the ages of 4-12. It is a program that helps the children with life skills and recreation. We allow the children to come year round, after school & in the summer. We have positive role models, that make sure that the local children, have all their needs met and get all the oppourtunities they deserve, in order to excel in life.
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Home > Reunions > 1966 50th Reunion > Hotels
Commencement will attract a large crowd, including many alumni, parents, and families from out of town. Rooms fill up quickly, so reserve yours today! To receive the special rates listed at each hotel, please mention the group name indicated below at the time of reservation.
Haven't been to Stockton in awhile? View an interactive map to see where each hotel is located in relation to campus.
This year the Hilton is the central hotel for the 50th reunion.
2323 Grand Canal Blvd.
Stockton, CA 95207
Hotel main: 209.957.9090
Release Date: April 21, 2016*
Group Name: Pacific 50th Reunion
Single: $129/night
Double Beds: $129/night
University Plaza Waterfront Hotel - SOLD OUT
110 W. Fremont St.
Stockton, CA 95202
Hotel Main: 877-957-2378
Release Date: April 21, 2016*
Group Name: UOP 50th Reunion
Signature King: $99/night
Waterfront Signature Double: $99/night
* NOTE: Release date means that these rooms will be released to the public at this date and no longer protected for this
group at the discounted rate.
For more Hotels in Stockton CLICK HERE
As of May 5th, the following hotels have confirmed rooms available for the weekend:
Econo Lodge Stockton
Address: 2654 W March Ln, Stockton, CA 95207
Phone:(209) 478-4300
La Quinta Inn Stockton
Address: 2710 W March Ln, Stockton, CA 95219
Phone:(209) 952-7800
Extended Stay America - Stockton - March Lane
*must stay 3 nights
Address: 2844 W March Ln, Stockton, CA 95219
Phone:(209) 472-7588


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2D animiaton work with Idea and Designs For Kids
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Buying guide: The truth about thread count
Is there anything better than sliding into a bed laden with good quality sheets? At the end of the day, I can't wait to stretch out under my fresh, soft covers and nestle my face into a good cotton-covered pillow. We spend a third of our lives in bed so quality sheets are key, but how do you get quality for your money? There's no doubt that most consumers believe the higher the thread count, the better the quality, but this isn't entirely true. With the help and expertise of Joanna Goodman, owner of Au Lit Fine Linens, we expose the truth about thread count and what it takes to find quality bed sheets.
What is thread count, really?
Simply put, thread count is the number of threads woven into one square inch of fabric. This number is based on the threads woven horizontally ("weft") and vertically ("warp"). Extra threads can also be woven into the weft threads to increase the thread count. These added threads are called "picks" and are added in the overall count, which is how some sheets end up having thread counts in the thousands. This is why the idea that high counts equal better quality isn't really accurate. Consider this: Joanna says most weavers will say the maximum number of threads that can be woven into one square inch of fabric is 500 to 600. Though the number is arguable and, according to Joanna, "depends on the mill you deal with," it gives you an idea of where the line is between single-ply, unpicked weaves and ones that add threads here and there to bump up the count.
What to look for when buying sheets
Joanna lists three things to look for on the label: if it's Egyptian cotton, where it's woven and, lastly, the thread count. While thread count is a bit misunderstood, the buzz around Egyptian cotton is true. "The very best cotton in the world is grown in Egypt. So Egyptian cotton will be of a better quality," Joanna says. She also recommends pima cotton, which is grown in America, "though not quite as exceptional as Egyptian." When it comes to weaving, however, she swears by the Italians as being the "master weavers of the world" due to their "long tradition of weaving" and use of the best Egyptian cotton. Be sure the label says 100% or pure Egyptian cotton though, otherwise it may only contain a small percentage of the good stuff. As for the thread count, look for a minimum of 200. From there, it's all about preference!
What to avoid when buying sheets
Joanna's one key piece of advice is to watch out for extremely low priced, high thread count sheet sets. A complete sheet set with a high thread count for $100 or less is probably not the dream bargain you think it is. As Joanna believes, "you always get what you pay for." The price tag for bed linens will vary depending on the sheet size and what items you're buying, such as a duvet cover, sheet sets, or pillowcases. "A superior quality 200 thread count queen set (including flat, fitted, two pillowcases), made of Egyptian cotton and woven in Europe, could retail reasonably for about $150-$250," says Joanna.
What do you prefer?
After going through the quality checklist, go with what feels best for you. If you're looking for a durable linen, Joanna recommends any percale from thread count 200 to 800. Percale is any cotton woven with a 200 thread count or higher and will be more durable than a cotton satin of the same thread count. It's also less likely to pill than cotton satin because it has a denser weave. Love the feel of a cotton button down shirt? Joanna advises a crisp, dense 200 thread count percale. Prefer a silkier sheet? Go for a 300 to 600 cotton satin. If you want lighter sheets, Joanna says, a 400 thread count sheet can be soft and light, while an 800 percale would be soft and dense. The higher the thread count, the more likely multiple-ply thread is used or picks are added, making the fabric denser and heavier.
Now you know that quality is not just about the number, so don't let numbers rule your bed! Remember what to look for on the label and be wary of too-low prices for supposedly high quality items. Beyond that, go with what you prefer. Get a good feel of the sheets before buying. Whether you're unzipping the packaging or lying down on a display bed, make sure the fabric feels good against your skin and soon you'll be having sweet dreams!
Find out how to keep your new linens crisp and clean with our tips to whiter-than-white sheets.
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1. The « Style at Home Thermador Bosch Contest » contest is held by (Groupe TVA) Style at Home . Groupe TVA Style at home is collectively hereinafter named: the "contest organizers". The contest runs on Styleathome.com, from August 22, 2016 to November 24, 2016 at 23h59 ET (hereinafter: the "contest period").
2. This contest is open to all persons residing in Canada of at least 18 years old of age. The following persons are excluded; employees, agents and representatives of Québecor Média inc., of Groupe TVA inc., of Style at Home, and Thermador of their parent and affiliated companies, their advertising and promotional agencies, partners, suppliers of prizes, materials and services related to this contest, or any other party directly linked to the holding of this contest, or their brother, sister, children, mother, father, their legal or common-law spouse and individuals with whom such employees, agents and representatives are domiciled.
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i) Once you have accessed the electronic entry form make sure to indicate your exact personal information as follows: first name, last name, complete address with postal code and country. It is every participant's responsibility to indicate a valid phone number where he can be reached between 9AM to 5PM during weekdays. Send your electronic entry form no later than November 24, 2016 at 23h59 ET. Upon reception of your registration's confirmation message, you will be automatically entered in the contest. Cookies must be accepted in order to participate to the contest.
Entrants must respect the following limits, otherwise the contest organizers reserve the right to cancel one or several of their entries :
• One participation per person per day during the contest period;
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One (1) prize will be given: Thermador – Sapphire Dishwasher
The total prize value is : 3,079.00 $ CAN
The following conditions apply:
• The prize is not exchangeable and non-transferable; and
• The prize has to be accepted as it is; and
• The contest organizers will determine with the winner the date; and
• If the prize or a portion of it is not used, no compensation will be given.
6. On November 25, 2016 at 10:00 am, in Toronto, at the office of Groupe TVA inc., a random selection of entry form will be held among all eligible entry forms registered in conformity with section 3, in order to attribute the prize described above.
7. The odds of a participant's entry form being randomly selected depend upon the number of eligible entry forms registered in conformity with the regulations and rules.
8. In order to be declared a winner, each selected entrant must :
a) Have answered correctly the mathematical skill-testing question that appears on the release form; and
b) Be contacted by phone and/or email by the contest organizers within three (3) days following the random selection; and
c) Sign the declaration and exemption form that will be given to him and return to the contest organizers within 5 days; and
d) Abide to all conditions related to the Prize;
After the declaration and exemption form is correctly filled out and signed, the contest organizers will contact the winner to determine how the Prize will be remitted (by mail or on hand delivery)
9. Failing to comply with one of the conditions stated in the section above or any of the conditions provided in these Contest Rules, the entry of the selected entrant will be cancelled without any liability to the contest organizers whatsoever, and a new draw for that prize will be held according to these Contest Rules until an entrant is selected and declared a winner.
10. Verification. Entry forms are subject to verification by the contest organizers, and contest entrants agree to cooperate fully with contest organizers in such respect. Any entry form which is, as the case may be, incomplete, fraudulent, sent late, that does not bear the correct answer to the mathematical skill-testing question will automatically be rejected and will not give right to a prize, and contest organizers shall have no liability in such respect, or in respect of lost, misdirected of garbled communication, printing, prizing or distributor errors.
11. Non-conforming entries. The contest organizers reserve the right to disqualify any person or cancel one or many entries of any person participating in this contest or trying to participate by means contrary to these Contest Rules or in a manner which is unfair to the other entrants (e.g.: entries exceeding the permitted limit, computer hacking, etc.). Such person may be referred to the appropriate judicial authorities.
12. Acceptance of prize. Any prize must be accepted as described in the present Contest Rules and cannot be transferred to another person, substituted for another prize nor exchanged in part or in whole for a sum of money, subject to what is stated in the following section. Prize is accepted "as is" without any warranty whatsoever.
13. Substitution of prize. In the event where, for reasons not related to the winners, the contest organizers cannot award a prize (or part of a prize) as described in these Contest Rules, they reserve the right to award a prize (or part of a prize) of the same nature and of equivalent value or, at their sole discretion, the cash value of the prize (or part of the prize) as mentioned in these Contest Rules.
14. Refusal to accept a prize. The refusal of a randomly selected person to accept a prize according to the terms and conditions of these Contest Rules releases the contest organizers of any obligation related to that prize towards that person.
15. Liability – prize's supplier. Each participant who is selected for a prize recognizes that upon reception of the confirmation of his status as the winner of the prize, the execution of the services in respect to the prize is the sole responsibility of the supplier of the prize, in this case, (Groupe TVA inc.) Style at Home. A declaration to this effect may be included in the declaration and exemption form.
16. Liability limit – use of prize. Any selected person releases Québecor Média inc., (Groupe TVA inc.), Style at Home, Thermador and their parent and affiliated companies, their advertising and promotional agencies, their employees, agents and representatives from any and all liability for any and all damages he/she may suffer from the acceptance or use of his/her prize. In order to be declared a winner, any selected person agrees, if required, prior to obtaining his/her prize, to sign a Declaration Form to such effect.Erreur ! Signet non défini.
17. Liability limit – running of the contest. Québecor Média inc., Groupe TVA inc., and (Groupe TVA inc.), Style at Home, Thermador and their parent and affiliated companies, their advertising and promotional agencies, their employees, agents and representatives are not liable for faulty computer components, software, or communication lines, relating to any transmission that is faulty, incomplete, incomprehensible or erased by any computer or network that could limit the possibility or prevent any person from participating in this contest. Québecor Média inc., (Groupe TVA inc.), Style at Home, Thermador and their parent and affiliated companies, their advertising and promotional agencies, their employees, agents and representatives also will not be held liable for any damages or loss that could arise, directly or indirectly, in whole or in part, from downloading any Internet page, any software or any form and by the transmission of any data regarding the participation in this contest.
18. Modification. The contest organizers reserve the right, at their sole discretion, to cancel, terminate, modify or suspend this contest, in whole or in part, in the case of the occurrence of an event, an error or any human intervention that could corrupt or affect the administration, safety, impartiality or the running of the contest as foreseen in these Contest Rules, subject to the approval of the Régie des alcools, des courses et des jeux du Québec, if required. In any case, the contest organizers, their parent and affiliated companies, their advertising and promotional agencies, the suppliers of products or services related to this contest as well as their employees, agents and representatives cannot be held liable to award more prizes than those indicated in these Contest Rules or to award prizes otherwise than in compliance with these Contest Rules.
19. Impossibility to act – including labour dispute Québecor Média inc., (Groupe TVA inc.), Style at Home, Thermador and their parent and affiliated companies, their advertising and promotional agencies, their employees, agents and representatives will not assume any liability whatsoever in any case where their incapacity to act would result from a fact or a situation beyond their control or a strike, lock-out or any other labour dispute in their establishment or in establishments of organizations or enterprises which services are used for holding this contest.
20. Liability limit– participation. Any person who participates or tries to participate in this contest releases the contest organizers, their parent and affiliated companies, their advertising and/or promotional agencies, their employees, agents and representatives, from any and all liability for damages which he/she could suffer from participating or trying to participate in this contest.
21. Authorization. By entering this contest, any winner authorizes the contest organizers, their partners and their representatives to use, if required, his/her name, photograph, likeness, declaration related to the prize, place of residence and/or voice without remuneration whatsoever and that, at their discretion and without limit as for the period of use, in any media and on a worldwide scale, for publicity purposes or for any purpose that will or may be pertinent.
22. Communication with entrants. No communication or correspondence will be exchanged with entrants in the context of this contest except with those selected for a prize.
23. Decisions of the contest organizers. All decisions of the contest organizers or those of their representatives regarding this contest are final and binding, subject to any decision by the Régie des alcools, des courses et des jeux du Québec in relation to matters under its jurisdiction.
24. Litigation. Any litigation respecting the conduct or organisation of a publicity contest may be submitted to the Régie des alcools, des courses et des jeux for a ruling. Any litigation respecting the awarding of a prize may be submitted to the Régie for the purpose of helping the parties reach a settlement.
25. Identification of the entrant. For the purposes of these Contest Rules, the entrant is the person whose name appears on the entry form and it is to this person to whom the prize will be awarded if he/she is selected and declared a winner.
26. Precedence: If an article in this regulation were to be declared or deemed illegal, unenforceable or invalid by a competent authority, then this article would be considered null and non-written, but all other items would not be affected and would find application in limits and authorized by law
27. Rules contest. This is the official regulations and rules for the contest « Style at Home Thermador Bosch Contest ».
28. Personal information. The personal information collected on the participants of this contest are used only for the administration of the contest. No commercial communication or other, not linked to the contest, will be sent to the participants by the contest organizers except if the participants have authorized the contest organizers, and in the case of Style at Home, Thermador it's affiliates, to send such communication by checking the opt-in on the electronic entry form.
Budget-friendly home makeover ideas on any schedule
Liven up your living space with these easy decor updates that will take anywhere from a day to a week.
When it comes to remodelling a home, we often can't help but dream big – because who doesn't want a walk-in glass shower, marble backsplash and ample storage space? But before you let your design vision overwhelm you, allow it to inspire you to make tiny tweaks that still have a big impact.
Whether you're tight on time or worried about stretching your budget too thin, we've compiled a list of affordable home makeover ideas that can be done on any schedule – from a day, to a weekend, to one week. It's time to set your decor hesitations to the curb along with that outdated side table, and read on.
For an instant refresh, switch up a space's furniture placement. Think seasonally: Make your fireplace the focal point in winter and reposition pieces in summer depending on how the light streams in. Don't be afraid to think beyond a room itself either – that armchair in your living room might look even better in your home office.
Lend a bright new look to your home by displaying eye-catching accessories. Uplift your sofa with playfully patterned toss cushions or scope out a stylish area rug to add comfort and texture to your space.
Think of bookshelves as fanciful art displays that should be carefully curated. Spend a quiet Sunday afternoon arranging your paperbacks by colour or wrapping unsightly book covers in pretty paper. Showcase decorative objets and prints for extra visual appeal. See here for more shelf-styling tips and tricks.
Don't have time to paint an entire room? Create an accent wall instead to achieve the same decorative punch. Paint the wall a vivid hue or select a graphic wallpaper pattern that demands to be seen. Learn how to design a show-stopping feature wall here.
Wake up tired furniture with a fresh coat of paint. Whether you want to refresh dated cabinets or revamp a dull dresser, new-and-improved furniture pieces will cheer up a room without breaking the bank. Find out how to make this DIY dresser makeover here.
While creating an accent wall can be completed in a day, devoting a weekend to the task affords you the opportunity to be more creative, and you'll have time to update a few walls. Try your hand at colour blocking or brighten a bedroom with intricate stencils and wall decals like these ones. Urban Walls, $71.66, etsy.com.
You don't have to rely on marble or glass mosaic backsplash tiles to achieve a timeless look in your kitchen (cue the sighs of relief). Instead, try self-adhesive wall tiles like Smart Tiles. The budget-friendly alternative is simple to install and will still give your space an effortlessly elegant feel. Mosaic Decorative Wall Tile Peel and Stick in Subway White, The Home Depot, $8.97.
Sometimes purging your pad can have just as dramatic an impact as redecorating it. Release yourself from constant clutter by editing every area in your home. Toss tattered items, corral products in stylish baskets and bins and opt for multi-functional furniture. Find 99 more easy organizing tips here.
First impressions are lasting, so spend a few days improving your home's porch area. Start by painting the front door an energizing hue that suits the exterior (here's how to choose a front door colour). To enhance the look further, dress up your porch with planters and replace your mailbox, doormat and number signs with more modern styles.
Bedeck your living room with a DIY gallery wall comprised of well-loved prints. Hang art pieces that range in size and shape for added dimension, and choose stylish frames (whether vintage or modern) that complement each other. Once all is said and done, you'll earn some serious bragging rights. Follow our steps for creating a DIY gallery wall here.
Making a few slight changes to your kitchen and bath will have big payoff. Begin by trading in timeworn hardware for sleek knobs and pulls, and paint your kitchen cabinets if they're looking a little worse for wear (here's how). Give yourself time to update other fixtures too, such as the faucets and vanity mirror.
Enhance the look of your dining or family room by adding decorative moulding. It's an architectural accent that will instantly uplift your space and lend it more character. Now is also the time to consider reupholstering old furniture (get inspired here) and revamping your floors, whether that means refinishing your hardwood (read: sand and stain) or installing new tiles.
Take your bedroom from boring to beautiful with a few creative upgrades. Get crafty by upholstering your own headboard, which creates an eye-catching focal point. For an even easier hack, use a bedsheet as the fabric like we did here. Boost your room's comfort factor further by adding an area rug, buying new bedding and installing drapery.
Once the weather warms up, our attention quickly shifts to the outdoors. Make your yard more inviting this year with a gorgeous garden path or walkway (materials like natural stone, brick and concrete all work well). Don't stop there. Take the time to paint your home's exterior – or at least the trim! – as well as the fence. Other easy tasks include washing the windows, staining the deck and painting outdoor furniture.


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Meze 11 Neo
" -Introduction- I review a lot of budget earphones in the $30–$60 range. It's not uncommon for me to review an earphone in this price range that's lauded as a giant-killer, only to be severely disappointed in it's lackluster performance. The 11 Neo challenges the notion that budget earphones need to be compromised in order to deliver both a dynamic listening experience and a solid..." --Cinder
Meze 12 Classics
The latest in the Classics series, the Meze 12 doesn't reveal itself immediately. The walnut wood housing changes, slightly, over time in tone and contrast. Its mystery isn't quick to vanish. The signature sound of a Meze, on the other hand, is and will be unchanged.
Meze Deco 11
Furthering our pursuit for pure expression through design we are proudly introducing the Meze 11 Deco earphones as a stylish yet practical device. It's more than an electronic gadget. It's your next favorite accessory. Elegant handcrafted beech wood enclosure reproducing crisp but warm, natural sound and a microphone on the flexible, non-tangle cord make this not only a performant...
JVC HA-FX101VR Inner-Ear Headphones (Red)
Ear-Clip Headphones for Light Sports With Bass Enhancement. JVC Xtreme Xplosives Inner Ear Headphones. Cordless: No. Headset Type: Headphones. Extreme deep bass ports and 8.5mm Neodymium driver units. Rubber protectors for durability. Superior sound isolation. Ergonomic contoured comfortable form. Cord length: 1.2m with gold plated slim plug. Includes 3 sizes silicone earpieces


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Teaching the Past to Form our Future.
Broadly trained and enlightened students have the basic skills for success in almost any imaginable vocation. In particular, students develop skills in research, critical thinking and writing. These skills are marketable in many career tracks.
History can be used as a double major, supplementing any other major by providing a historical perspective and research skills.
With regard to graduate education, students have many options. The most obvious is graduate education in history. Yet students often successfully pursue graduate studies in theology, law, humanities and other fields. This opens doors to many careers: One can work in ministry, law, politics, education and business, to name a few. Even students who do not pursue a graduate education find myriad opportunities.
Recent graduates are working in business, law offices and web management companies. The three skills noted above are in demand and are often not developed in more vocationally focused programs. In effect, they translate well into many fields, and thus equip history students to explore many options and plot their course in life. Students taking History with the Secondary Education Program track are qualified once they pass the certification tests to teach History at the middle and high school level.
- School: Traditional Undergrad Academics
- Division: Teacher Education
- Degree Type: Bachelor of Arts
- Format: Residential
- Location: Grand Rapids
Quick Facts
- Major Credit Hours: 30 (requires minor)
- Minor Credit Hours: 21
- Application Deadline: Rolling admission
- Fall semester—August 15
- Spring semester—January 1
Degree Completion
Download a sample degree plan for a major in History for Secondary Education.
Internship Opportunities
- Museums (ex: Gerald R. Ford Presidential Museum; Coopersville Farm Museum)
- Archives (ex: Grand Rapids City Archives; H. Henry Meeter Center for Calvin Studies)
- Libraries (ex: Lincoln Township Library in Indiana)
- Non-profit organizations (ex: St. Cecelia's)
- International service organizations (ex: Women at Risk International)
- Archeological projects
- Law Offices
Graduate Outcomes
Major Courses and Catalog
In addition to completing the university's core curriculum and professional education courses, the Bachelor of Arts in History for Secondary Education degree requires the following classes:
- HIS-113 World Civilization I (3 credit hours)
- HIS-114 World Civilization II (3 credit hours)
- HIS-211 Michigan History (3 credit hours)
- HIS-221 United States History I (3 credit hours)
- HIS-222 United States History II (3 credit hours)
- HIS-451 Historiography I (2 credit hours)
- HIS-452 Historiography II (1 credit hour)
- Program electives (12 credit hours)
For course descriptions and graduation requirements, view the 2016-17 Cornerstone University Undergraduate Academic Catalog.
Begin Your Admission Application
Take the next step toward joining Cornerstone University's thriving, student-focused community in Grand Rapids, Mich. Submit a free application for admission today.


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Other Artists:
Diana Coidan
Cecilia Guitarte
Patricia Pittman
Kelly Frost
Artist for special exhibits and other events.
Rick McClure
John Poon
Jean Grunewald
Bert Sult
We are currently NOT taking any new artists, but you are welcome to submit your website for future special exhibits or other projects.
Wyn Easton
Dan Nelson
Kimberlee Maselli
David Oakley
Lyudmila Tomova
Renee Crawford is a native North Carolinian, born in Durham and raised in Winston-Salem. After living in Massachusetts and Philadelphia for college, and then in Oregon for graduate school, she came home and settled in Raleigh in 1986 to stay for good. Renee received her Master of Fine Arts from the University of Oregon in 1986 and her Law Degree from Duke University in 1996.
Renee paints in oil, focusing on portraits, figurative studies, still lifes and landscapes. She has studied with international Master Impressionist Jerry Fresia as well as nationally-known artists Albert Handell, John Poon, Dan Beck, Michelle Dunaway and Daniel Gerhartz, as well as Raleigh's own Nicole White Kennedy and Dan Nelson.
Her major influences are Joaquin Sorolla, Richard Schmid and Claude Monet. Renee is a juried member of Oil Painters of America and Women Painters of the Southeast, as well as a member of the American Impressionists Society, the Portrait Society of America and Raleigh's Visual Art Exchange.
Visit Renee's website for more info
on the artist, artwork, pricing, availability:
Renee Crawford
A Woman's Peace
22 x 28 oil
Samples of Eileen's recent work-
please contact the artist or visit her website
for details and availability
Eileen Hendren
Chinatown Shoppers
30 x 40 oil on canvas
Eileen Hendren
Bargain Hunters
24 x 18 oil on canvas
Nicole's Studio Artist in Residence
Eileen embraces her artistic journey with an eye toward everyday lifestyles and forms in nature. She applies an expressionistic and passionate painting style as she eagerly explores new ideas, as seen recently in her NYC fashion window series - a fresh perspective on the figure imbued with a nostalgic flair.
Eileen loves working in oils and is passionate about the history of oil painting. The way it fills your senses The richness of art history worldwide and its evolution over time. And the passion and sense of self which artists invest in their work, with the knowledge that one never reaches the end of their artistic journey.
Eileen loves to travel, and has painted scenes from across the world, "where stories happen." She is thrilled to be a part of the Raleigh art community, it's energy and the sense that something special is emerging and growing. Eileen is a graduate of Duke University and has a Masters of Architecture from NCSU. She continues her artistic master studies in the Triangle, Colorado and
in New York City.
Visit Eileen Hendren's website for more info
on the artist, artwork, pricing, availability:
• EileenHendrenArt.com
• Follow Eileen on Facebook
Eileen Hendren
Nude 3
18 x 18 oil oil on canvas
Eileen Hendren
Bucket of Love
22 x 28 oil on canvas
Eileen Hendren
Breakfast Meeting
40 x 30 oil on canvas
Click Here for Nicole's Scenic Landscapes
Architect, Bert Sult started painting cityscape watercolors a few years ago and in a short period his works have garnered a wide following.
Known predominantly for European, New York and iconic steet & landmark scenes, his loose, lively, masterful use of watercolor and expressive method of wet in wet lost edges juxtaposed with lines and figures imbue a distinctly sophisticated, nostalgic yet ethereal tone.
Combining controlled washes with soft edges against areas of line and detail creating intentional light, shadow and shape patterns livened up with people moving the viewer around the scene is a lifetime goal many watercolorists pursue and Sult's work rises to this challenge consistently.
Bert Sult has been in numerous group & solo exhibits throughout NC.
John Poon
La Luce del Pommeriggio
The light in the Afternoon
12 x 9 acrylic - custom framed
John Poon
Country Homestead
24 x 30 - custom framed
Rick McClure
Deep in the Woods
18 x 24 oil on canvas
Cecilia Guitarte
White Pots
11 x 14 oil on canvas - gallery wrapped
Oil paintings by Cecilia Guitarte have a clean graphic style with a keen eye for lighting nuances and a focus on everyday subjects elevated to high art. From sliced fruit and vegetables to mist-shrouded trees, serene skies and whimsical still lifes, Cecilia's distinct detailed imagery stands apart "My paintings are based on photos taken around my home and on my travels. I see lines and shapes, darks and lights and try to accent what has caught my attention. I have a very logical mind, so I like to simplify the objects and the colors that I use; I liked clean lines and a smooth surface" It's no wonder Cecilia gets juried into numerous prestigious shows, including being juried into the National Oil & Acrylic Painterz Society in 2015 and 2016. In the Raleigh Fine Arts show judged by NC Museum Director Larry Wheeler and the N.E.W Show juried exhibit at VAE. She won 1st place in the 2012 Small Treasures exhibit at the Cary Gallery and in 2011 won Honorable Mentions in the Fine Arts League of Cary annual exhibit and the NC State Fair Juried Exhibit. She is in numerous private and corporate art collections both local and in her home country, Argentina.
Read More About Cecilia
Diana Coidan
Anchored for the Catch
27 x 33 pastel - matted with custom frame
Diana Coidan
On the Edge Again
27 x 33 pastel - matted with custom frame
Diana Coidan
Golden Moment
13 x 11 pastel - matted with custom frame
Please contact the gallery to
view these works before coming in
David Oakley
Sailboats on the Potomac
30 x 40 oil on canvas - custom framed
Please contact the gallery to
view these works before coming in
Jean Kolb Grunewald
Distant Views
24 x 30 oil on canvas - custom framed
Dan Nelson
Wake Forest Art Walk
24 x 30 oil on canvas
Kimberlee Maselli
Delightful Interlude
30 x 40 acrylic on canvas
Kim Maselli's artwork explores a wide range of subject matter, with a strong focus on landscapes, coastal and woodland scenes. Her bold brushstrokes, palette knife texture and vibrant use of color leads the eye into her paintings and the viewer is invited to explore the subtle complexities and unfolding narrative.Kim is a rising star on the regional "en plein air" art scene. In 2011, three of her pieces were juried into the national Jack Richeson miniature exhibit and 4 into the Landscape International Juried exhibit. Kim was included in the International Charvin Plein Air competition in '09 and received national recognition in American Artist's NC Plein Air competition. She also authored TWO beautiful Coffee Table Book: Painting North Carolina, "En Plein Air.. Kim's works are in numerous Corporate Collections throughout the Triangle.
Kim is one of the Art Instructors at Nicole's Studio
Read More about Kim Maselli


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Bill Hader Movies
Stefon's 10 Best Moments From SNL. Bill hader. Hilarious. Laugh. Funny. Buzzfeed.
"Authentic. Loving. Celebratory. Time-specific." That's how Fred Armisen describes Documentary Now!, an IFC comedy (debuting Aug. 20) that spoofs and pays tribute to the genre with a six-episode showcase of mockumentaries about fictitious historical subjects (often rooted in real life), each unspooled in a different filmmaking style.
Funny Mans,Funny Guys,Funny People,Snl Funnies,Funnies Random,Bill Hader Stefon,Comedians Snl,Snl Tho,Snl Sorrows
Bill Hader SNL40 interview
We're all either Bill Hader or Andy Samberg.
GQ - Bill Hader
Almost filed this under "yum," which would have been equally true tbh.
Bill Hader (Photo by Victoria Will/Invision/AP) Great Lighting and expression on Bill Hader.
bill hader is so funny i laugh thinking about him. (Plus he writes for South Park, way to win me over) #KnockedUp #Superbad #ForgettingSarahMarshall #PineappleExpress #Adventureland #CloudyWithAChanceOfMeatballs #MenInBlack3 #TheMindyProject #SNL
So sad about Bill Hader leaving SNL but this was the perfect weekend update send off.


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Types Of Dresses
Right. Here is it everything you ever wanted to know about fashion cuts, trends, style, all in one post. Every example of a trend that existed is list in the above post. So get to know your styles, perfect your image and enjoy mixing trends and different eras together
Modcloth Dress Ed- helpful for knowing what type of dress your looking at.
Types of Skirts fashion vocabulary. A-line, tube, circle, pencil, accordion, mini, knife pleated, wrap, draped, asymmetrical, gypsy, bubbled, layered, godet, mermaid, tulip, ruffled, paneled. https://enerie.wordpress.com/2014/05/28/the-ultimate-skirt-vocabulary/
Gli Arcani Supremi (Vox clamantis in deserto - Gothian): I nomi dei diversi tipi di gonna
The ultimate dress shape vocabulary More Visual Glossaries (for Her): Backpacks / Bags / Bra Types / Hats / Belt knots / Coats / Collars / Darts / Dress Silhouettes / Eyeglass frames / Eyeliner Strokes / Hangers / Harem Pants / Heels / Nail shapes / Necklaces / Necklines / Puffy Sleeves / Shoes / Shorts / Silhouettes / Skirts / Tartans / Vintage Hats / Waistlines / Wool Source: Enerie Fashion
Terms for the fit of a dress http://sussle.org/t/Dress
different types of dresses
Everyone knows that deep décolletage adds a flavour of the sexiness and catches the eye. Other types of necklines also have its' advantages. Refresh your wardrobe and do not forget about this detai...
Forum | Learn English | Sleeves Fashion Vocabulary | Fluent Land
Visual Show Dictionary is very handy! I've never known the names for all of these!


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Copenhagen Free Walking Tours
Want to know more about princes and princesses, vikings and power struggles? Copenhagen Free Walking Tours invites you on a memorable trip through the city.
Copenhagen Free Walkings Tours offers a free tour of the city, every day of the year. The tours run in all kinds of weather, however with a minimum of five guests.
The classic Copenhagen Free Walking Tours starts at Copenhagen City Hall at 11:00 and takes you to the major attractions in Copenhagen, such as Strøget, Tivoli (from the outside), Nyhavn and Amalienborg Palace.
The Christianshavn Free Walking Tours starts at 16:00 from Bishop Absalon's Equestrian Statue on Højbro Plads square in inner city and takes you on a tour of the Christianshavn area. It finishes in Freetown Christiania.
All tours are in English. The tours are free, but if you enjoy it, you are welcome to leave a tip for the guide.
|Opening hours
|01/01/2015 - 31/12/2020
|Saturday, Sunday
|12:00 - 13:30
|01/01/2015 - 31/12/2020
|Monday - Sunday
|15:00 - 16:30
|01/05/2015 - 31/12/2020
|Monday - Sunday
|11:00 - 14:00
Last updated byWonderful Copenhagen firstname.lastname@example.com
- Guided tours
CoordinatesLongitude : 12.5688222
Latitude : 55.6760633


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All Entries Tagged With: "collaborative"
Kidimedia: First Collaborative Educational iPad App For 3-7 Year Olds
Posted by Press Releases | Jan 05, 2011 | 0
Designed to entertain, stimulate and challenge young children, Kidimedia brings collaborative education of 3-7 year olds to the iPad. Kidimedia features a variety of educational games like jigsaw puzzles, counting and reading games, logical brainteasers and more. Parents and teachers can create and share these games using user-friendly wizards. What sets Kidimedia apart, is its ability to automatically download extra games from the Kidimedia website, so there's always something new to play.
OpenStreetMap Viewer 1.1 – Universal Collaborative Maps
Posted by Press Releases | Dec 01, 2010 | 0
First Flamingo Enterprise B.V. today released OpenStreetMap Viewer 1.1 for iPhone, iPod touch and iPad. The app offers an easy view method of the collaborative, world wide OpenStreetMap project. Users can enjoy full screen imagery, seamless zooming tools, a scale bar and optional location awareness to take advantage of the detailed mappings. OpenStreetMap is a free, editable world map, created and maintained by thousands of knowledgeable volunteers from around the globe.