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The 2010 South by Southwest music and technology conference (SXSW) in Austin, Texas, earlier this month could easily be mistaken for a twisted game of musical chairs: The jambalaya of independent artists, industry suits and iPhone-carrying fanboys in attendance hopped from flea bars to dance halls to bookstores, in search of live shows–never knowing when the music would stop. Some of the biggest acts–jazz team Sharon Jones and the Dap-Kings, British upstarts The xx, electro-stylists Major Lazer, and a revanchist Bone Thugs-n-Harmony–thrilled packed lawns and auditoriums throughout the week. But some bands labored in obscurity, playing their unique brand of acoustic rap, or Tejano ska, to a few tipsy watchers in empty restaurants.
This divide, between the haves (bands with fans) and have-nots in Austin undergirds a heated political conversation that will grow as the spring and summer concert season unfurls: What to do about Live Nation Entertainment, the Frankenstein-ish conglomerate formed when Ticketmaster and Live Nation merged in January 2010. When the two companies became one–after faint protest from independent promoters and the concert-going community–they planted the seeds of a significant intervention in the future of music.
The company's new mission statement is "to maximize the live concert experience." In practice, this means putting on upwards of 22,000 shows around the world, selling 140 million tickets and reeling in nearly $6 billion in revenue. But this success comes at the expense of consumers, and a recording industry going through major adjustment pains. As digital music (20 percent of Rihanna's revenue comes from ring tones) and live shows (ticket sales were up 4 percent in 2009, despite the recession) replace album sales as the primary source of revenue in the music industry, the mega-company could reach further into the wallets of eager fans. And its potential monopoly could throw independent, grassroots musicians off the biggest stages permanently.
The Biggest Loser
Ticketmaster was founded in 1976 by graduate students in Arizona who developed software to sell many tickets, at the same time, from many places. Before that, seeing a big band on tour meant standing in line outside your favorite theater (romantic perhaps, but frustrating). Today, Ticketmaster charges for the "convenience" of eliminating that wait time–collecting $1.1 billion dollars annually on these fees alone. Live Nation, which began to snowball in 1996, took care of getting bodies in the door come show time. Backed by capital from SFX radio stations (themselves the subject of antitrust accusations), Live Nation grew from a handful of regional promoters into a well-oiled confederation of professional promoters and dedicated venues (such as the House of Blues franchise) that, by 2000, ran 80 percent of the concert market. Its new artist management division offers "360" promotion deals that ensures megastars like Jay-Z, U2, Lady Gaga or Dave Matthews' Band can simply wave a hand and have 100 sellout shows lined up around the world.
Music fans probably know each entity as its own company. But Live Nation Entertainment–a hydra-headed promotions, ticket-selling or re-selling, merchandising and management company–is about to become a household name. The new corporation, whose $889 billion merger required a controversial waiver from the U.S. Justice Department, will own about 80 percent of a $4.4 billion annual concert production marketplace.
It's no surprise the new company has removed all traces of "Ticketmaster" from the new name. Over 30 years, the brand has come under fire from big names in the music business, from Pearl Jam in 1995 to Bruce Springsteen in 2009. Fans have also endured their price-gouging methods and instant sellouts. Under Ticketmaster's reign, ticket prices rose 160 percent since 1999 (well over the pace of inflation)–not to mention the cost of the shirts, beers and hot dogs Live Nation sells at a premium to smitten fans.
This attempt to merge and rebrand unpopular practices displeased many musicians I spoke with. "It's so hard to make money on the promotions side," says Eddie Sumlin, an independent R&B musician in Austin. "Friends of mine are fighting tooth and nail for all of the top-line shows. They take big risks to have the big names," he adds–with no guarantee that bands will choose them over the bigger fish. Indie darlings Vampire Weekend, for example, skipped SXSW this year–all of their North American appearances are being managed by the new conglomerate. Even before the merger, Live Nation could hassle and squeeze out anyone who tried to pierce the bubble of management, sales, and promotion they had placed around "their" artists. Joel Flynn, a musician and professor at the University of Vancouver, recalled some film work he tried to do with New York City band The National. "Every year they'd come back [to Vancouver] a little bit bigger, and by the third year they were at the Commodore. We set up a recording session as we'd done in previous years. And two days before the show, I get a call from Live Nation, which owns the Commodore, saying: 'If you're going to film here, you're going to have to pay what's called an 'origination fee' of $8,500.'" Needless to say this was an effective deterrent.

subset: commoncrawl


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We are hoping to fly via Dublin to Boston & wondered if anyone had experience of doing a connecting flight. We arrive Dublin at 11.40am, flight to Boston departs 2.15pm is 1hr 25mins enough time to clear immigration? Have contacted Aer Lingus who say as our luggage will be going straight through to Boston, we should be ok providing we don't linger.
Have checked flight times for other departure points & nearest flight to ours leaves about 1 hr before so our flight should be the only one clearing immigration after 1pm.
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US Immigration in Dublin
We are hoping to fly via Dublin to Boston & wondered if anyone had experience of doing a connecting flight. We arrive Dublin at 11.40am, flight to Boston departs 2.15pm is 1hr 25mins enough time to clear immigration? Have contacted Aer Lingus who say as our luggage will be going straight through to Boston, we should be ok providing we don't linger.
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As I understand it, the Irish government has allowed the US to set up a pre clearance system at Dublin airport. Therefore when you arrive in the USA, you will have already cleared immigration and customs...therefore it will be no different than any other connecting flight within the USA...you get off the plane, find the location of the gate. You may or may not have to clear security again depending on the lay out of your arrival airport. Therefore should be enough time.
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The OP already recognizes preclearance in Dublin and the question is whether there is enough time in Dublin to clear US Immigration.
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"is 1hr 25mins enough time to clear immigration? "
I'm not quote getting your question -- 11:40 to 14:15 is 2 hr 35mins . . .
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I was confused with the mention the op's bagge is going straight through to Boston, perhaps the EI personnel were too. What difference does it make where the baggage is coming when being pre cleared in Dublin? In any event, I am sure Aer Lingus has minimum check in times based on this listed on their web site or other information they provide.
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oops - meant >>I'm not quite getting your question<<
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US Immigration--passport control--is in Dublin, but customs is not. So the bags will be checked through to the US, where the passenger will bypass immigration and go straight to baggage claim, then through Customs.
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Didn't know that...my only experience with pre clearance was in Canada where I believe you go through immigration and customs in Canada....defeats part of the purpose of pre clearance as usually at least in my experience, the immigration lines are pretty much thinned out before the baggage comes down the chute and you carry it through the customs inspection.....important part of the connecting flight procedure on international flights i.e. waiting for luggage, clearing customs and returns the bag to the airline. Also means yu have to go through security again when if you are making an intra line change on a domestic flight, often times you simply walk form one gate to another.
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Yes, Ireland (and a few Caribbean islands I think) is different from the situation with the big Canadian airports. Having both customs and immigration in Toronto, Vancouver, etc., allows flights between Canada and US destinations that lack international arrivals facilities, such as Washington National DCA. From Dublin and Shannon, flights go only to large US international airports.
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US government pre-clearance locations.
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Sale! Robin's Nest 100g Handpainted Skein, Greatest of Ease, ready to ship
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Luxury handpainted variegated yarn, hand-dyed just for you! Gorgeous, saturated denim colors change quickly from one to the next in this handpainted skein. Coordinates perfectly with the Pigeon Chromatic Gradient yarn.
Greatest of Ease - fingering (80% superwash Merino/20% nylon) - 400 yards/100g. Great stitch definition, soft and springy. Our most popular base.
*Robin's Nest Handpaint* features shades of twig brown, turquoise, and light robin's-egg blue.
Care for all of our yarns: Hand or machine wash cold (delicate cycle), dry flat. Our yarns are colored using professional-grade acid dyes.
We've made every effort to photograph the color accurately, but appearance may vary with your monitor settings.


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Wairgo 50 N Buoyancy Vest - Grey
Ref :
Key feature
50 N instantly inflatable and deflatable buoyancy vest using gas refill or mouth.
Users reviews
5 / 5 1 rating
User benefits
50N inflatable/deflatable buoyancy vest certified with Standard EN ISO 12402-5
Freedom of movement
Patented ergonomic shape which leaves arms free.
Easy dressing
Adjustable waistband with adhesive band. Zip fastening.
Versatile shape designed for kayaking, Stand Up Paddling, surfing, kitesurfing
660 g with bottle size M
Outside Shell - Main fabric : 94.0% Polyamide (PA), 6.0% Rubber - Chloroprene (CR) - Neoprene Inner fabric : 100.0% Polyamide (PA)
Tested with a stand up paddle (SUP), dinghy, kayak, when surfing, touring with fins, kitesurfing, windsurfing.
made for
occasional to regular participants of watersports.
2 years
Care instructions
Check the product has been correctly prepared before venturing on outings. Rinse in fresh water. Ensure any water which has entered the cover has been drained using the valve subsequent to deflation.
Storage Tips
Dry well before storing for a long period of time. After storing for a long period of time, blow strongly into the pipette or apply pressure on the spacer to unblock it.
2 inflation systems: 1/ manual trigger: pull on the red handle on the left side of the chest, inflation will begin immediately using the gas tablet. 2/ inflation using the mouth: blow into the pipette to the right, after 3 blows, the vest will be fully inflated to 50 N.
Pull on the red strap on the right shoulder to open the valve. Deflate the vest by pulling it back using the hand. This valve also serves as an excessive pressure valve to protect the product from excessive pressure.
Changing the gas refill.
Single use gas refill. To replace: 1/ access the actuator (left side of chest) 2/ unscrew the used refill 3/ fully lower the metal lever (IMPORTANT so as to avoid piercing the new refill) 4/ replace the green plastic indicator 5/ screw a new refill by threading it through the red strap.
Users reviews
5 / 5 1 rating1 users recommended this product
JonathanMan30-39 years old10 April 2016Use since 2 to 8 weeksI recommendThat review has been deposited on this product versionpurchase confirmedtriboard life vestno restriction in movement only comes with one gas bottle
Really good vest. Had it out on the Atlantic ocean off Donegal on my sit on kayak. Really lite weight not as bluky as a bouancy aid. Your movement is not restricted at all. Reall good product.
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Papa John's Pizza Locations, Interactive Maps, Phone, Website and More
All Brands » Papa John's Pizza
From Company Website
As a high school student working at a local pizza pub in Jeffersonville, Indiana, Papa John's founder John Schnatter realized that there was something missing from national pizza chains: a superior-quality traditional pizza delivered to the customer's door. His dream was to one day open a pizza restaurant that would fill that void.
In 1984, "Papa" John Schnatter knocked out a broom closet located in the back of his father's tavern (Mick's Lounge), sold his prized 1972 Z28 Camaro, purchased $1,600 worth of used restaurant equipment, and began selling his pizzas to the tavern's customers. The customers loved the pizza so much that John was able to expand by moving into adjoining space, eventually leading to the opening of the first Papa John's... more
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*From the Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN.
Correspondence to: Ping Yang, MD, PhD, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: firstname.lastname@example.com
While outcome research in lung cancer has focused mainly on short-term survival and quality of life (QoL), information on long-term (ie, > 5 years postdiagnosis) lung cancer survivorship remains limited. This review addresses the epidemiologic significance of long-term lung cancer (LTLC) survivors, summarizes the current knowledge on their health and QoL, and suggests areas for further research in LTLC survivorship. Based on a small body of literature, lung cancer survivors do not experience the same quantity and QoL as their age-matched peers or as survivors of other cancers. Survival among 5-year survivors of lung cancer relative to the general US population with the same demographic characteristics is approximately 60%, and lung cancer survivors score lowest in health utility among long-term survivors of other cancers. Approximately one-quarter of long-term lung cancer (LTLC) survivors were significantly restricted in physical ability or reported significant depressive symptoms. There is a need to identify and intervene with subgroups of survivors who are at an elevated risk of premature death and diminished QoL. Lung cancer-specific survival alone does not reflect the overall illness burden in LTLC survivors. Patient care in lung cancer survivors should be continuous and comprehensive in considering multiple causes of health deterioration. Multidisciplinary research in epidemiologic, clinical, and basic science approaches is warranted to further our knowledge base for optimal long-term management and to develop the necessary intervention strategies among LTLC survivors.
Cancer survivorship research is pursued to identify, examine, prevent, and control adverse outcomes related to cancer diagnoses and treatment; to provide a knowledge base regarding optimal follow-up care and surveillance of recurrent or new disease; and to optimize the health of patients after cancer treatment.1Prior studies2have focused mainly on the survivors of childhood cancer, and long-term survivorship in patients with adult-onset cancer has only gained attention during the past decade and is a developing field in cancer outcome research. The progressive improvement of survival in several common adult-onset cancers3and the wide recognition of quality of life (QoL) as an important end point have necessitated the pursuit of this field of research. Long-term survivors of lung cancer are underrepresented in this field of research.4 The pursuit of survival remains the exceedingly important priority in lung cancer research, and the high mortality rate has been a barrier to the development of QoL research in the relatively few long-term survivors.
An estimated 170,000 persons were diagnosed with primary lung cancer in the United States in the year 2005;5although overall survival remains low,6approximately 26,000 individuals will become long-term lung cancer (LTLC) survivors every year in the US population. More than 140,000 LTLC survivors were present in the United States as of January 1, 2001,7 and this number is expected to increase. The practice of low-dose CT scanning as an early detection tool could also increase the number of 5-year survivors of lung cancer.
Changes in patient management and survival in patients with early-stage non-small cell lung cancer (NSCLC) may have brought about the majority of the LTLC survivors. After years of research evaluating the benefit of adding systemic therapy to surgery, two phase III trials8–9 have shown an absolute survival benefit of 12 to 15% with the use of adjuvant chemotherapy in patients with stage I and II NSCLC. The survival benefit seen in these trials provides resounding approval for adjuvant chemotherapy being the new standard of care for patients with surgically resected early-stage NSCLC.10 However, it is probably too early to see a big change in survivorship due to adjuvant therapy. This type of treatment is only now becoming more common and will never be appropriate in all patients.
Advancements in treatment have also potentially improved long-term survival in patients with limited-stage small cell lung cancer (SCLC). In 2002, the change in survival among the control arms of 30 phase III clinical trials involving patients with limited-stage SCLC conducted during 1972 to 1992 in North America was compared with the survival rate of limited-stage SCLC patients seen in the Surveillance, Epidemiology, and End Results (SEER) database during the same timeframe.11 While a concordant improvement in the median survival rate was observed, the 5-year survival rate in the SEER database doubled from 5.2 to 12.1%.11
Population growth and aging will also likely impact the number of long-term cancer survivors including lung cancer in the future. When the cancer incidence rates from the past few years are applied to the US Census Bureau population projection between 2000 and 2050, the total number of cancer patients is expected to double, and the number of cancers occurring in persons aged ≥ 65 years may double within 30 years.12 The "Annual Report to the Nation on the Status of Cancer"12 concluded that, despite the decrease in cancer death rates and the stabilization of cancer incidence rates, the overall growth and aging of the population could significantly increase the burden of cancer in the United States.
In 1994, Schag et al13 reported that lung cancer survivors experience more physical and psychosocial problems than survivors of colon or prostate cancer. In their analysis, the length of survival was not associated with QoL ratings in lung cancer patients; however, only five LTLC survivors were included in the study.13Some analyses of large population-based cancer survivor cohorts14–16 have suggested that lung cancer survivors experience a heavy burden of illness that may persist for a prolonged period of time.
QoL was evaluated in a patient cohort that was identified from the 1998 National Health Information Survey (NHIS)14 including 54 lung cancer survivors, 92 melanoma survivors, 377 breast cancer survivors, and 169 colon cancer survivors. Health utility as measured by the Health and Activities Limitation Index was assessed according to the time from diagnosis, that is, in acute periods (ie, < 1 year), short-term periods (ie, 1 to 5 years), and long-term periods (ie, > 5 years). The mean health utility score in lung cancer survivors was lowest (indicating the worst QoL) among all cancer sites, and for both acute and long-term periods.,14 In this study, 20 individuals were LTLC survivors.
Hewitt et al15 reported the health and disability status among 4,878 cancer survivors based on the NHIS conducted from 1998 to 2000. Relative to female breast cancer survivors, survivors of lung and respiratory (larynx and pharynx) cancer reported significantly poorer general health status and were bothered by more psychological problems.15
Yabroff et al16 compared the general health status, limitations in activity, and health utility among 1,823 cancer survivors and 5,469 matched control subjects who were also identified from the NHIS. Cancer survivors had poorer health outcomes when compared to control subjects, and the measures of illness burden in cancer survivors remained similar regardless of the interval since diagnosis. Lung cancer survivors, when combined with survivors of esophagus, liver, pancreas, and stomach cancer, reported greater illness burden than the survivors of cancers in all other sites.16
Recognizing an increasing number of lung cancer survivors and the paucity of information in all perspectives of their health and QoL, the demand for research has mounted. Figure 1
, a variant derived from a general conceptual model proposed by Wilson and Cleary,17illustrates a five-dimension working model that captures the health and QoL; emphasizing the quality and the quantity of a LTLC survivor's life. The biological submodels (ie, primary disease-related or host-related) have a primary focus on the biology, physiology, and clinical presentation; and the psychosocial models have a primary focus on mood, support systems, and coping strategies. Specifically, noted are molecular alterations in lung tumors that have been extensively studied in hopes of identifying additional parameters to explain variability in survival.22 The most commonly examined or promising potential protein markers that represent expressed genes in key pathways of cancer development and progression should also be evaluated among LTLC survivors. The corresponding antibodies to proteins are commercially available, and their prognostic value, if identified, could be readily usable.
The functional status or drug metabolism systems of the host also play a role in the fate of a lung cancer patient. Genomic variations of genes responsible for the immune response to the tumor, drug metabolism, or DNA repair systems may be part of the underlying mechanisms affecting long-term adverse clinical outcomes, as has been determined in their role in lung cancer development and progression, and short-term survival.23–27 Issues of the significance of genetic susceptibility to a variety of environmental exposures, treatment-related toxicity, and vulnerability to poorer health and worse QoL need to be further investigated simultaneously.
The evaluation of QoL with particular focus on LTLC survivors has been limited to that of two cross-sectional cohorts14,28–31 (Table 1
). Sarna and colleagues,28–30 evaluated the demographic and clinical characteristics and QoL among 142 NSCLC patients who had survived for a minimum of 5 years (range, 5 to 22 years; mean, 10 years). The investigators utilized the Quality of Life-Cancer Survivors tool (QOL-CS) and the Medical Outcomes Study 36-item short form (SF-36) to measure QoL outcomes, and the Center for Epidemiologic Studies depression scale (CES-D) to assess distressed mood as a risk factor for poor QoL. While the majority of survivors self-reported that they were in "good" general health, QoL varied widely. When compared to published aggregate norm scores of the SF-36 physical component (PC) and mental component (MC) for a sample of older adults (age, 65 to 74 years),28 lung cancer survivors scored similarly in both measures. Seventy percent of survivors reported their general health status as "good to excellent," despite 70% having comorbid medical conditions, 52% having impaired pulmonary function (ie, FEV1, < 70% predicted), and 66% having existing respiratory symptoms.,28–29 Greater than 70% of the participants described themselves as hopeful, and 50% of participants viewed their cancer experience as contributing to their positive life changes (as determined by QOL-CS).28However, 21% of the survivors were restricted largely to bed rest and 11% could not leave the house due to severe respiratory symptoms.29 Approximately 25% of patients felt fatigue and/or were bothered by aches or pain. Twenty-two percent scored ≥ 16 on the CES-D,28 indicating significant depressive symptoms or distressed mood.
In a multivariable assessment, distressed mood was found to be a significant and major predictor of a worse score for all three QoL measures (ie, QOL-CS global score, SF-36 PC, and SF-36 MC). For the SF-36 PC, older age and having more comorbid conditions were significantly associated with a diminished QoL.28In a separate multivariable assessment of QoL including respiratory symptoms, the presence of dyspnea had a significant impact on QoL subscales as measured by the SF-36 MC and PC. The authors reported that comorbid unstable angina was positively associated with severe distress due to dyspnea. Other factors significantly influencing QoL were the total number of comorbidities, the total number of respiratory symptoms, and marital status.29
Evangelista et al30 evaluated health risk behaviors including smoking, exposure to second-hand smoke, alcohol consumption, and weight control (overweight) in the same cohort. Eighteen percent of patients were currently smoking, 58% consumed alcohol, and 51% were overweight at the time of the survey. All four risk behaviors were associated with a perceived poor health status, and the authors addressed the need to promote lifestyle changes to improve QoL.30
A subsample of 29 participants31 from the parent cohort of Sarna and colleagues28–30 was interviewed, and issues resulting in changed conception of life, awareness of health and self-care, changes in physical ability, adjustment to changes, and appreciation and willingness to give back for received support were recognized as important to their QoL. Survivors expressed themselves differentially (ie, positive vs negative) on these issues when grouped into those with distressed mood (CES-D score, ≥ 16) and those without distressed mood (CES-D score, < 16). Demographic and clinical factors, such as age, gender, cancer histology, treatment, and time since diagnosis, between the two groups were similar; whereas, mean scores for the SF-36 PC and MC were both lower, and comorbidity was more common among those in the distressed-mood group.31
Twenty LTLC survivors were included in a separate cross-sectional evaluation of QoL within a larger cancer survivor cohort.14 When the mean health utility score among LTLC survivors was compared to that of lung cancer survivors within the first year of diagnosis, LTLC survivors scored substantially higher (by 47%); however, this was not a longitudinal evaluation of the same patients over time, and the results may be biased. In a multiple regression model evaluating predictors of health utility in LTLC survivors, the presence of pain or a history of angina had significant negative impact on the measured outcomes.14
The long-term adverse consequence of cancer treatment has received limited attention among patients with adult-onset cancers.32Especially in lung cancer patients, the high mortality rate has made it difficult to adequately assess treatment-related late toxicity.33The association between treatment modalities and QoL has not been assessed in LTLC survivors, and no studies have evaluated longitudinal changes of QoL in patients following treatment for their lung cancer over a period of > 2 years.34–39
Several studies have shown that physical domains of QoL deteriorate early after lung cancer surgery but improve to baseline by 6 months after surgery.34–36 To the contrary, Mangione et al37 reported a persistently declining perception of general health, vitality, physical function, and bodily pain at 12 months after surgery. Impaired cardiopulmonary function following pulmonary resection is an important predictor of immediate postoperative morbidity; meanwhile, an objective assessment of pulmonary function did not significantly contribute to QoL in LTLC survivors.29 Instead, the survivors' perception of symptoms was important to QoL, implying the need for monitoring respiratory symptoms after a thoracotomy.29 Chronic pain is the most common complication after lung cancer surgery and, indeed, was one of the most commonly reported problems among LTLC survivors.28 A usually mild but chronic pain after lung cancer surgery is known as the postthoracotomy pain syndrome and is seen in up to 80% of patients following a thoracotomy, with severe and disabling pain occurring in 5%.,40Pain could last for > 4 years in approximately 30% of the patients.41 The exact etiology and risk factors for chronic postthoracotomy pain are not well-understood.
The occurrence of clinical pneumonitis and changes in pulmonary function are well-known adverse effects of radiation therapy. Radiation pneumonitis, defined as grade 2 or higher according to the South-West Oncology Group toxicity criteria,42–43 was reported in 15 to 20% of lung cancer patients receiving external-beam radiotherapy. The results suggested older age, low performance status, low pulmonary function, high radiotherapy dose, and chemotherapy exposure as possible risk factors.42–44 To evaluate the relative influence of the late toxicity of radiotherapy on long-term survival, Machtay et al45 calculated the risk of death from intercurrent disease following postoperative radiotherapy in NSCLC patients. Age and radiotherapy dose were marginally associated with a higher risk of death from intercurrent disease; however, the actuarial survival rate at 4 years was only minimally decreased when compared to a matched population.45
Many chemotherapy agents cause cardiopulmonary or other toxicities, and several studies46–48 have suggested a higher risk of perioperative complications when chemotherapy is administered before pulmonary resection. Information is scarce regarding the long-term adverse effects of chemotherapy in lung cancer patients.
In general, cancer survivors with other comorbid conditions (comorbidity) possess a 5-to-10 times higher likelihood of poor health and disability when compared to individuals without a history of cancer or other chronic diseases.15 In older cancer survivors, the presence of comorbidity was significantly correlated with impaired functional status regardless of the period of time from their cancer diagnosis.49The prevalence and severity of comorbidity has been reported to be especially high in lung cancer patients when compared to survivors of other cancer sites.50–51 However, the relative impact of comorbidity on 1-year survival was among the lowest and was disproportionate to the survival rates.52Although most studies report a detrimental effect, the reported relative impact of comorbidity on lung cancer survival is not consistent among studies53–55 and may be influenced by the different methods of data collection or by the use of different assessment tools.55 Although the relative impact of comorbidity on survival in LTLC survivors is largely unknown, the frequency of comorbid conditions was significantly related to both the physical and mental health domains of QoL.28 Comorbid angina was a cause of adverse influence on QoL among LTLC survivors in two studies.14,29
Cancer recurrence and the occurrence of new primary cancers are life-threatening clinical events that plague the course of lung cancer survivors. While noting the difficulty in differential diagnosis, many studies56–76 have evaluated the occurrence of these events, as summarized below.
Although late recurrence has been reported > 10 years after an initial diagnosis of NSCLC,68the majority of recurrences are detected within 2 years after the patient undergoes surgical resection.69 Several studies68–71 have reported a 4 to 5% prevalence of recurrent disease in 5-year survivors following surgical resection. Two cohorts69,72 of disease-free 5-year survivors of stage I NSCLC have reported an incidence rate of 2 to 3% per patient-year.
Lung cancer survivors are at an increased risk of the development of subsequent primary cancers, including those of the lung. Johnson et al73 summarized that the risk of developing second lung cancers and other aerodigestive tumors in treated lung cancer patients is approximately 10-fold higher than that of adult smokers. The occurrence of subsequent primary lung cancer (SPLC) in patients undergoing surgical resection for NSCLC has been estimated to be 1 to 2% per patient-year.73 The incidence of SPLC was reported to increase two-fold after 5 years of surgery when compared to 5 years after surgery.69 The cumulative risk of SPLC or other smoking-related cancers reaches 13 to 20% at 6 to 8 years after the patient undergoes resection of NSCLC.73
An especially high risk of the development of SPLC has been reported in patients with treated SCLC.73 The risk per patient-year has been reported to increase from 2 to 13% after the passage of ≥ 10 years. The cumulative risk of the development of SPLC results in a striking 30% at 10 to 12 years after the initial treatment.71 Chest radiotherapy and continued smoking were found to significantly increase this risk.74
Limited information is available regarding long-term survival rates among lung cancer patients at the population level. Wingo et al77 reported survival rates at 5, 10, and 15 years among patients with breast, prostate, colon and rectum, and lung malignancies who received diagnoses from 1974 to 1991, based on data collected by the SEER program (Table 2
). The relative survival rates were calculated by dividing the observed survival rates for each cancer diagnosis by the survival rates of the general US population with the same gender, race, and age characteristics. Unique to lung cancer survivors was an apparent trend in relative survival in which a higher age at diagnosis was positively associated with a worse survival rate, regardless of race, gender, stage, or length of follow-up. When conditional relative survival rates (ie, the 5-year survival rate among LTLC survivors relative to matched subjects) were calculated in 5-year and 10-year survivors of lung cancer, they were approximately 10 to 30% lower than the same measures observed in other cancer survivors (Table 3).,77 The results indicate that even after LTLC long-term survival, lung cancer patients are still substantially vulnerable to the risks of death from all causes and that elderly survivors have a more pronounced risk.
Favorable disease-specific survival in NSCLC patients has been described in two large cohorts of 5-year survivors following surgical resection.71,78 Martini et al71 followed 686 5-year disease-free survivors of NSCLC in resected stage I-IIIA. The estimated 10-year survival rate, when accounting only for lung cancer-related deaths, was 92.4%.71 Okada et al78 reported a similar 10-year survival rate of 91% in 421 5-year survivors. Martini et al71 reported that among the 369 5-year survivors, 76 had died before 10 years; 18 (24% of all causes of death) from lung malignancy and 58 (76%) due to other causes. Other studies68,79–80 have reported lung malignancy to account for 29 to 49% of all deaths noted among 5-year survivors of NSCLC following surgical resection; however, follow-up time varied among these studies.
The survival characteristics beyond 5 years in patients receiving nonsurgical treatment for NSCLC have been documented in limited reports. In a follow-up study81 of 49 5-year survivors after undergoing radical radiation therapy for NSCLC, the overall actuarial 10-year survival rate was 65%. Among patients who were free from disease progression at 5 years, 81% remained free from disease progression at between 5 and 10 years.81Long-term follow-up data from clinical trials that evaluated the role of combined chemotherapy/radiation in the treatment of unresectable NSCLC were reported by the Cancer and Leukemia Group B,82and the Japan Clinical Oncology Group.83 The estimated survival rates for the study arm receiving combined-modality treatment was 19% at 5 years and 13% at 7 years in the Cancer and Leukemia Group B 8433 trial,82and was 14% at 5 years and 12% at 7 years in the six Japan Clinical Oncology Group trials.83 In the latter study,83 the authors noted no deaths after 7 years following treatment.
Lung cancer survivors do not experience the same length of life and QoL as their age-matched peers or other cancer survivors. Lung cancer patients fare less well than survivors of other cancers because the nature of the cancer (ie, cancer affecting a vital organ) as well as the predominant smoking history of most of the patients. There is clearly a need to identify and intervene with subgroups of patients who are at an elevated risk of premature death and diminished QoL.
Defining a conceptual model as a guide, such as that in Figure 1, analyses should focus on disease-specific survival as well as survival from competing causes of death in order to thoroughly evaluate the illness burden in lung cancer survivors. As the aging of the population is inevitable, survivors of lung cancer, especially those who are elderly, should receive continuous attention regarding their health and QoL beyond the expected cure of their primary cancer. Advanced age is associated with other chronic health problems; thus, the assessment of comorbid conditions is extremely important and should be carefully conducted.84–85 Methodologies in comorbidity assessment among lung cancer survivors call for further development.55,85 Little information is available on the assessment of the late effects of cancer treatment in lung cancer survivors. A change in standard patient management, including the wider application of multimodality treatment options may or may not influence the significance of the issue of the possible late side effects of treatment. The occurrence of secondary cancers is an important health matter among LTLC survivors. These events should be further evaluated for risk factors, including the genetic and molecular effects of smoking and lung cancer treatment and the susceptibility possessed by the host and primary tumor.
The impact of multiple factors that influence medical complications and QoL in LTLC survivors needs to be better characterized individually and in combination. The significance of the interaction between aging-related comorbidities and frailty, and the adverse effects of lung cancer therapy, smoking, and their relationship with the vulnerability for subsequent death or other causes of health deterioration are largely unknown.32 An understanding of these factors will allow precise risk estimation for efficient disease prevention strategies. One of the most important, and also challenging, steps is to establish a representative patient population to allow multidimensional research,32 which will enable the assessment of a longitudinal change in QoL and allows for an estimation of significant predictors of QoL in their relationship to different time points in survivorship. Finally, intervention research on behavioral changes should be promoted to generate accurate knowledge as well as to develop long-term management and intervention strategies.
A PubMed search was performed to identify articles published in the English language up to March 2005 using the key words "(lung) neoplasms," "quality of life," and "(long-term) survivors." The references of relevant articles were also consulted. The literature was reviewed for pertinent information with emphasis placed on studies reporting clinical outcomes, especially in LTLC survivors. Clinical factors that were considered to be relevant to these outcomes, including lung cancer treatment, comorbidity, and the occurrence of secondary cancers, were additionally reviewed with a focus on their long-term influence.
Abbreviations: CES-D = Center for Epidemiologic Studies depression scale; LTLC = long-term lung cancer; MC = mental component; NHIS = National Health Interview Survey; NSCLC = non-small cell lung cancer; PC = physical component; QoL = quality of life; QOL-CS = Quality of Life-Cancer Survivors tool; SCLC = small cell lung cancer; SEER = Surveillance, Epidemiology, and End Results; SF-36 = Medical Outcomes Study 36-item short form; SPLC = subsequent primary lung cancer
This work has been supported by the US National Institutes of Health through research grants awarded to Ping Yang (CA 77118, CA80127, and CA 84354).
HALex = Health and Activities Limitation Index.
This study was conducted as a subgroup analysis within participants of the parent study by Sarna et al.28
Partially adapted from several tables within the article by Wingo et al.77
Observed survival divided by survival rates for gender-matched, age-matched, and race-matched subgroups for the general US population.
Relative survival rates restricted to 5-yr survivors.
Relative survival rates restricted to 10-yr survivors.
The authors acknowledge Susan Ernst for her technical assistance with the manuscript.
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text:
Chemically Castrate the TSA
Promoting commonsense ideas to make us all safer from terrorism
An open letter to the TSA and the flying public:
Recently there has been
over the new screening methods being employed by the
Transportation Security Agency (TSA)
. These new screening methods include
"enhanced pat-downs"
, which may include genital and breast contact, and
"advanced imaging technologies"
, which employ machines that can let TSA agents see through traveler's clothes, producing "
" images.
Critics contend that these techniques go to far and seem to be particularly bothered by the potentially sexual nature and overtones, while the TSA says that they are necessary to guarantee traveler's safety.
We would like to offer a modest proposal
to allow TSA to continue to conduct these scans while addressing traveller's fears of real or perceived sexual overtones to the pat-downs and "naked" scanners.
We suggest that all TSA employees
who may be involved in performing pat-downs or traveller body imaging, or who select travelers for these screening,
undergo a procedure commonly known as "
Chemical Castration
a simple, non-surgical procedure wherein the employee would be given medicines and/or hormones that suppress sex drive and urges.
By ensuring that screeners can have no sexual motives
for performing these more thorough screenings or selecting particular passengers for examination, travelers can feel comfortable undergoing these screening techniques. Many people who would otherwise object on grounds of religious or personal beliefs will be able to participate, and reduced disagreements over screenings will allow TSA to focus on catching terrorists,
making us all safer.
Thus, knowing that the TSA employee can receive no gratification from genital nor breast contact nor from seeing naked images of traveller's body will go a long way to making these screenings more acceptable, and thus
chemical castration of TSA screeners is an important step in assuring the safety of our airways from terrorism.
We know that some people may feel this is going to far and places too much of a burden on screeners, or perhaps unfairly even treats TSA employees as criminals, but as TSA director Pistole and many others have said,
we must all make sacrifices for security
This is a reversible procedure, and
like AIT scanners, chemical castration has been deemed safe by the government
Finally, we know that some TSA employees may object anyway. While we regret that, we understand, and remind those employees that
like flying, working for TSA is a privilege, not a right
We wish all travelers understood the need for enhanced screenings, and all TSA employees understood the need for chemical castration. Fortunately, while not everyone will, travelers do have other options besides air travel, and TSA employees who do not feel comfortable with chemical castration can find other employment. We hope the majority of TSA employees understand that this small sacrifice is necessary for the safety of all of us, and will comply.
The Committee to Castrate the TSA
Chemically Castrate the TSA
© 2010 The Comittee to Castrate the TSA


text:
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three or all four slots.


text:
Irish gay rights group says civil partnerships "a matter of immediate urgency"
Post your comment
Comments on this article are now closed.
Reader comments
The Irish government has gone completely silent on this issue since publishing the Heads of Bill. Some of us feel they are hoping we'll forget all about it. Meanwhile the media don't regard it as a sexy subject. While you have covered this story today, none of the major Irish newspapers have. The Irish Times instead features an article on rights for (presumably heterosexual) cohabiting couples: http://www.irishtimes.com/newspaper/ireland/2008/1023/1224625123846.html
All the while, some of us are not getting any younger, and I would like to make good on my 'civil partnership' proposal to my partner of 14 years as soon as possible!
Frieda, Dublin
I hope the Irish government drops this bill. If civil partnerships become law in Ireland the struggle for gay equality will die in Ireland as it seems to have died in the UK> I would rather wait 5 or 10 years and finally get equality like they have in Spain; Holland; Belgium & Canada than accept this 2nd class relatioship status. Civil partnerships are not equality. But once they become law it makes it almost impossible ever to achieve equality. I am also disgusted that GLEN in Dublin are meekly accepted this 2nd class citizenship on behalf of the gay community in Ireland.
Both of yous above have valid points.
Frieda – I object to the fact that I will be "single" until the day I die, even if, I am in a long term stable relationship as I am in now.
However, I am in agreement with Simon. This needs to go back to the drawing board. LGBT groups need to consulted.
I would hate to see this Bill offered as "Irish solution to an Irish problem" – citing C. Haughey on the introduction of contraception. Look at the fiasco over 20 years that turned out to be.
No half measures this time, unfortunately, Irish governments are very fond of doing this.
To my brothers and sisters back home take heart! If civil partnerships become law in Ireland…consider it a step in the right direction!!! :)
Back here in the states…we had the same dilemma and worried…In most cases…what was a civil union…became a marriage because eventually each state simply moved forward and made marriage legal.
In the mean time…if you guys are feeling left out…come here to beautiful Mystic, CT, where plenty of your fellow countrymen live and I'll marry you and you'll have the time of your life!!! :)
Peace & :)
Marie Tyler Wiley
These comments are un-moderated and do not necessarily represent the views of PinkNews. If you believe that a comment is inappropriate or libellous, please contact us.
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text:
Latina March and Vigil to Stop Violence Against Women
Latino Agencies United to Stop Violence Against Women hold their the annual Vigil and March in the Greater Washington DC Metro area for the Latina community. Come support and help us make noise to educate and create awareness about domestic violence in our Latina immigrant community. The march begins at Lamont Park in Mt. Pleasant ends in front of the Suntrust Bank on 18th & Columbia Rd. NW.


text:
Cedars Open Studios Exposed the Day-to-day of Local Artists
All photos by Alex Scott
On Saturday, as a part of the 9th annual Cedars Open Studios, more than 60 artists provided the opportunity to share a little insight into their own creativity by opening up their studios to the public. Complete with food, music, and of course, wine, most studios were at capacity with the steady flow of patrons and the curious passersby alike.
The studios were independently as unique as the individual artwork created within, whether it was glass blowing, photography, or expressive hula-hoop dancing.
All photos by Alex Scott
I started my tour at the Art Hotel Gallery, where the artists - 15 in the Art Hotel alone - rented the space as a co-op, effectively lowering the sale prices for the lack of commission. Just two doors down was Groovy Monkee tattoo, where owner Matt Beasley proudly displayed his and his tattoo artist' work; but not in tattoo form.
"It can be skin or any other medium," said Beasley, "everyone here is an artist full time."
Upcoming Events
An Evening With Kim Fields
TicketsFri., Nov. 4, 8:15pm
24-HOUR FILMFEAST Featuring the Films of Thomas Allen Harris
TicketsSat., Nov. 5, 12:00pm
Casa Manana Presents Million Dollar Quartet
TicketsSat., Nov. 5, 2:00pm
Scott Joplin Chamber Orchestra Of Houston
TicketsSat., Nov. 5, 5:00pm
TicketsSat., Nov. 5, 8:00pm
Right down Akard a few blocks sits the Re Gallery + Studio, conveniently located next to Lee Harvey's, (which wasn't just the favorite pit stop of the day, but showcased artwork itself). Inside the Re gallery were spectacular pieces solely from recycled, repurposed and reclaimed material.
The mood of the day was uncommonly communal and warm, especially for late November. It was no better felt than in South Side on Lamar where the artists opened up their studios, which also happen to be their homes. Most know that the South Side flats used to be an old Sears warehouse, but right where the loading docks used to be now, the multi-purpose place has store-front style studios specifically for artists, with their apartments located behind.
One occupant named Sam Fuller, but better known as the man behind "Old Black Man Art", came to own one of these studio/flats by means that echoed the themes of the day. Inside, his jazz inspired paintings and drawings, provided a strange backdrop in where he told me that just a year or two prior, he was homeless on the street. But he kept true to his art, and by a stroke of luck was actually contacted by the MTV show The Buried Life.
The premise of the show is where four young men are completing their "bucket lists" but not without helping someone down and out along on the way. MTV producers got in contact with Sam and not only found his estranged son, which he hadn't seen in 17 years, but put his art on display as well, starting in the South Side coffee shop, Opening Bell.
Fast forward to last Saturday, and Sam was happily working on a new piece as hundreds came in to look at the artists in the South Side Studios. Even though it is in its 9th year, the Cedar Open Studio event is invaluable to the community, and judging by the overall response, will be a continued tradition throughout Dallas.
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text:
Shaking Up Statistical Physics in Interacting Quantum Systems
Physics Colloquium, Thursday, February 18th, 2016
Speaker: Anushya Chandran, Perimeter Institute
Statistical mechanics is a central pillar of modern science with applications ranging from sociology to economics. At its core is the idea of thermal equilibrium, which allows for a simple description of an interacting quantum system in terms of a few properties like temperature, without keeping track of the entire wavefunction. But what if a quantum system fails to equilibrate?
In this talk, I will discuss how we are discovering the answer to this question theoretically and experimentally. I'll focus on two settings: disordered systems and periodically driven systems. In the former, many-body localization can prevent thermalization even at very high energy densities. The transition between the localized and the thermal phase is a fascinating dynamical quantum transition about which little is known. I will derive a rigorous constraint on this transition and apply it to current numerical studies and cold atomic experiments. Clean periodically driven systems, on the other hand, generically absorb heat indefinitely. I will present one physical setting of interacting bosons in which this expectation fails.
Time: 4:00-5:00pm
Location: 100 Willamette Hall
Host: Dietrich Belitz
Physics of Information Processing in Living Systems
Physics Colloquium, Thursday, February 11th, 2016
Speaker: Yuhai Tu, IBM T.J. Watson Research Center
Living organisms need to obtain and process information that are crucial for their survival. These information processes, ranging from signal transduction in a single cell to image processing in the human brain, are performed by biological circuits (networks). However, these biochemical or neural circuits are inherently noisy. Yet, certain accuracy is required to carry out proper biological functions. How do biological networks process information accurately and efficiently? What is the energy cost of biological computing? Is there a fundamental limit for its performance? In this talk, we will describe our recent work in trying to address these questions in the context of two basic cellular computing tasks: sensory adaptation for memory encoding [1,2]; biochemical oscillation for accurate timekeeping [3].
[1] "The energy-speed-accuracy trade-off in sensory adaptation", G. Lan, P. Sartori, S. Neumann, V. Sourjik, and Yuhai Tu, Nature Physics 8, 422-428, 2012.
[2] "Free energy cost of reducing noise while maintaining a high sensitivity", Pablo Sartori and Yuhai Tu, Phys. Rev. Lett. 2015. 115: 118102.
[3] "The free-energy cost of accurate biochemical oscillations", Y. Cao, H. Wang, Q. Ouyang, and Yuhai Tu, Nature Physics 11, 772, 2015.
Time: 4:00-5:00pm
Location: 100 Willamette Hall
Host: Dietrich Belitz
Do two-dimensional metals exist?
Physics Colloquium, Thursday, February 4th, 2016
Speaker: Michael Mulligan, Stanford University
Conventional wisdom teaches us that electrons confined to a two-dimensional quantum well will do one of three things as the temperature is lowered to zero: superconduct, insulate, or exhibit the so-called quantum Hall effect. (Here, I am concentrating on the types of order as revealed in electrical charge transport; finer distinctions can be made, e.g., magnetic ordering.) Nature, however, is stubborn and doesn't always listen. In this talk, I will describe two experimental systems that surprisingly appear to violate the conventional wisdom and instead exhibit a metallic phase at zero temperature. I will argue that there is a deep analogy between the two systems that relates their behaviors and discuss how such novel metallic phases can explain other unconventional low-temperature quantum orders.
Host: Dietrich Belitz
LSST: a color movie of the Universe coming near you!
Physics Colloquium, Thursday, January 28th, 2016
Speaker: Željko Ivezić,, University of Washington
The Large Synoptic Survey Telescope (LSST) will carry out an imaging survey covering the sky that is visible from Cerro Pachon in Northern Chile, with first light in 2019. With close to 1000 observations in ugrizy bands over a 10-year period, this data will enable deep coadded maps across half the sky reaching hundred times fainter flux level than the Sloan Digital Sky Survey (SDSS). About 20 billion galaxies and a similar number of stars will be detected in these maps — for the first time in history, the number of cataloged celestial objects will exceed the number of living people. The time-resolved observations will open a movie-like window on objects that change brightness, or move, on timescales ranging from 10 seconds to 10 years. With a raw data rate of about 15 TB per night (about the same as one SDSS per night), LSST will collect over 100 PB of data over its lifetime, resulting in an incredibly rich and extensive public archive that will be a treasure trove for breakthroughs in many areas of astronomy and physics, ranging from the properties of near-Earth asteroids to characterizations of dark energy and dark matter. I will provide an overview of the main science drivers and a status report for the federally-funded construction project that started in 2014.
Host: Spencer Chang
Emerging Phases and Phase Transitions in Quantum Matter
Physics Colloquium, Thursday, January 21st, 2016
Speaker: Thomas Vojta
Missouri University of Science and Technology
Condensed matter physics deals with the complex behavior of
many-particle systems. Novel phases of matter can emerge as a
result of strong interactions between the constituent
particles. A natural place to look for these phenomena are
quantum phase transitions, the boundaries between different
quantum ground states of matter.
This talk first gives an introduction into quantum phase
transitions and then discusses several novel phases of matter
that have been discovered in their vicinity in solids and in
ultracold atomic gases. These include exotic superconductors
and magnets as well as Griffiths phases that are dominated
by strong disorder.
Host: Dietrich Belitz
Non-perturbative Results for Itinerant Ferromagnetism in Multi-orbital Systems
January 14th, 2016
Speaker: Yi Li
Princeton Center for Theoretical Science, Princeton University
Title: Non-perturbative Results for Itinerant Ferromagnetism in Multi-orbital Systems
Itinerant ferromagnetism (FM) is intrinsically a strongly correlated phenomenon, which remains a major challenge of condensed matter physics. Most FM materials are orbital-active with prominent Hund's coupling. However, the local physics of Hund's rule usually does not lead to the FM long-range order. Furthermore, the magnetic phase transitions of itinerant electrons are also long-standing problems difficult to handle by using perturbative methods. In this talk, I will present non-perturbative studies on itinerant FM. Exact theorems are established for a stable itinerant FM phase in a large region of electron densities in multi-orbital systems, which provide sufficient conditions for Hund's rule to build up global FM coherence. In addition, thermodynamic properties and magnetic phase transitions of itinerant electrons are studied via sign-problem-free quantum Monte Carlo simulations at generic fillings. Without introducing local moments as a priori, the Curie-Weiss metal behavior is identified in a wide range of temperatures. These results will provide important guidance to the current experimental search for novel itinerant FM states in a large class of systems ranging from the transition-metal-oxide heterostructures (e.g. LaAlO3/SrTiO3) to the p-orbital bands in optical lattices filled with ultra-cold fermions.
Is there a Dark Sector or was Einstein Wrong?
Physics Colloquium, Thursday, December 3rd, 2015
Speaker: Scott Dodelson, Fermilab
Observations over the past decade suggest that most of the energy in the Universe is in the form of Dark Energy and Dark Matter. The hunt is on for the identity of these new substances as we strive to understand how they fit in to the rest of physics. Recently, attention has turned to another possibility: there is no dark sector but Einstein's theory of gravity needs to be modified. We are now faced (again!) with a contest between two competing ideas: Change the fundamental laws of Nature OR Introduce new substances. Which will win and how will we find out?
Host: Graham Kribs
Click here to view Fall 2015 schedule:
Title: Advanced Particle Accelerator R&D
Physics Colloquium, Thursday, November 19th, 2015
Speaker: Mark Hogan, SLAC National Accelerator Laboratory
Particle accelerators are the ultimate microscopes. They produce high-energy beams of particles – or, in some cases, generate X-ray laser pulses – to probe the fundamental particles and forces that make up the universe and explore the building blocks of life. But it takes huge accelerators, like the 2-mile-long SLAC linac, to generate beams with enough energy and resolving power. If we could achieve the same thing with accelerators just a few feet long, accelerators and particle colliders could be much smaller and cheaper. Eighteen years ago, SLAC began an exciting series of experiments aimed at accelerating electrons and positrons to high energies in a much shorter distance by having them "surf" on waves of hot, ionized gas like that found in fluorescent light tubes. These "plasma wakefield acceleration" experiments have been mounted by a diverse group of accelerator, laser and plasma researchers from national laboratories and universities at FACET, the Facility for Advanced Accelerator Experimental Tests, which uses the first two kilometers of the SLAC linac. Mark Hogan reviews the history of these experiments, the current program at FACET and plans for the future at FACET-II.
Host: Jim Brau
Click here to view Fall 2015 schedule:
Title: The Black Hole Information Paradox, Alive and Kicking
Physics Colloquium, Thursday, November 12th, 2015
Speaker: Joe Polchinski, UC Santa Barbara
Thought experiments have played an important role in figuring out the laws of physics. For the unification of quantum mechanics and gravity, where the phenomena take place in extreme regimes, they are even more crucial.
Hawking's 1976 paper "Breakdown of Predictability in Gravitational Collapse" presented one of the great thought experiments in the history of physics, arguing that black holes destroy information in a way that requires a modification of the laws of quantum mechanics. Skeptics for years failed to poke holes in Hawking's argument, but concluded that if quantum mechanics is to be saved then our understanding of spacetime must break down in a radical way. For a time it seemed that Maldacena's discovery of gauge/gravity duality had resolved the issue, but the recent firewall argument has opened many new questions.
Host: G. Kribs
Click here to view Fall 2015 schedule:
Birds, magnets, soap, and sandblasting: surprising connections in the theory of incompressible flocks
Speaker: John Toner, University of Oregon
In this talk I'll describe the hydrodynamic theory of the motion of incompressible flocks: that is, collections of self-propelled entities ("birds") that are packed so tightly together that their density cannot change as they move. In two dimensions, this problem can be mapped onto an equilibrium magnet with a peculiar constraint. This problem, in turn, can be shown to be equivalent to a 2d smectic ("soap"), with the flow lines of the flock playing the role of the smectic layers. Finally, this smectic problem can be mapped onto the 1+1 dimensional KPZ equation, which describes the growth or corrosion ("sandblasting") of a one dimensional interface. The scaling properties of this last system, which have been known exactly for a long time, can thereby be used to determine those of incompressible 2d flocks. One important implication of the resulting scaling laws is that such flocks can exhibit long-ranged order in two dimensions, unlike their equilibrium counterparts.
Click here to view Fall 2015 schedule:


text:
Docket light for court term
Circuit Court in Tunica County started the March-April 2012 term last Monday, with 67 cases on the calendar, some dating as far back as 2005-2006. Judges Webster, Walls and Smith will hear cases during this term.
The schedule is as follows:
March 26, Judge Webster - 11-0036 J. Stevenson, auto theft: 11-0068 K. Smith, aggravated assault/shooting into motor vehicle; 12-0003 K. Powell, fondling; 10-0076 K. Dorsey/M.Terry, burglary of dwelling; 10-0024 D. Grant, felony malicious mischief; 10-0034 M. Stafford, embezzlement; 12-0032 C. Davis, shoplifting; 10-0095 S. Perdue, uttering forgery; 10-0097 C. Wilkins, uttering forgery.
Relay for Life 2012
Inaugural run helps son, soldier live on
The memory of one of Tunica's fallen sons will be honored next month during a community run that will assist other military-minded individuals pursuing their educations.
The first-ever Enduring Freedom Run is an event established by the family of slain Army PFC Brandon Dawson and the Tunica County Chamber of Commerce. The event is scheduled for Saturday, April 7, and will take place along a roadway in eastern Tunica County that was dedicated to the memory of the serviceman, who died in Afghanistan on September 24, 2010.
Navigating internet highway requires parental supervision
Parental monitoring is critical to the health and well-being of adolescents, whether the issue is Internet use or behavior in general.
Tommy Phillips, assistant professor in Mississippi State University's School of Human Sciences, said although parents do not want to look over their teen's shoulders constantly, a reasonable level of supervision is essential.
More Articles...
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text:
YouTube's Pogo, a.k.a. Nick Bertke, is back with yet another Disney-inspired earworm.
The Australian electronic music artist sampled music and dialogue from classic Disney films like "Pocahontas," "Cinderella" and "The Little Mermaid" to create a remix fit for a rave.
Pogo is known for using samples from classic movies and TV shows to create trippy dance tunes. Previously, he's created remixes using snippets from The Muppets, Scooby-Doo, Harry Potter, "Mary Poppins" and even "Pulp Fiction."
Listen to his latest creation above.
Also on HuffPost:
Celebrities Who Look Like Disney Characters
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text:
An asinine adventure through the world of high fantasy.4.46 / 5.00 2,473 Views
Nothing To Fear
Super villainy at its worst ...4.17 / 5.00 3,444 Views
The Ascent of Alfred
Make Alfred Great Again4.11 / 5.00 16,216 Views
Not to be mean though it does sound rude.. sry>.<_
not to sound mean but when you say march, do you mean march of this year or something like march of next year?... cus false hope gets annoying, i dont mind you taking forever cus its good and the more time u spend on it then obviously it will be better, but thinking it comes out only to be let down and disippointed gets annoying...
are you sure it will be on march? or are you just saying that?
I 'm at the very end of the episode now, so i need to finish the last scene, add the sound fx and menus, bells and whistles and it's all set.
man can you create episode 5???please!!!
I'm sorry, i will finally finish the last episode. Look for it in March.
Great following supposed story line
Protoman has to die cuz he wasn't going to live long anyway.
http://megaman.wikia.com/wiki/Mega_Ma n_Wiki
read the megaman wiki, a must bookmark for all megaman fans.
Great movie. Please continue making series unles you don't have time or your flash licence has ran out of time.
haha dont worry i did purchase my copy of Adobe Flash. Will try to finish it soon.
this story plot actualy makes sence


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Hotels in Villadepera, Spain
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Hotels in Villadepera
- Most bookedPosada Real La Mula de los Arribes
7 people looked at this hotel in the last hour
Hotels within 10 miles of Villadepera
11 people looked at this hotel in the last hour
8 people looked at this hotel in the last hour
Most recent review
"A very well priced hotel ideal for transit purposes. Very warm welcome and service, clean, basic but comfortable. We would use again."
A Traveller, May 2015, US
8 people looked at this hotel in the last hour
8 people looked at this hotel in the last hour
6 people looked at this hotel in the last hour
Most recent review
"Returning here after 15-20 years, when it was a state-operated pousada. Present owners have done their best to maintain the luxury, but it's a losing battle with few clients. The dinner is excellent and very reasonably priced; the breakfast just average at best. The view is as it always was, SPEC..."
A Traveller, Sep 2015, US
Hotels within 15 miles of Villadepera
- Posada Real El Molino de LosacioNo Guest Reviews yet
4 people looked at this hotel in the last hour
Hotels within 25 miles of Villadepera
37 people looked at this hotel in the last hour
Most recent review
"One night only, but it was a great location. Super clean. Friendly staff. Opted for the breakfast - lots of options."
A Traveller, Jul 2016, US
21 people looked at this hotel in the last hour
Most recent review
"We stayed on our way to Portugal and on our way back. Staff was helpful and nice. We esecially enjoyed live music outside on the grass area during dinner on Friday night."
A Traveller, Aug 2016, US
13 people looked at this hotel in the last hour
Most recent review
"Looked a little disappointing drone the outside but once inside WOW! It was a lovely building and the service and food was excellent. The Old city was close by and very interesting. Couldn't fault the place."
A Traveller, Jun 2015, GB
Best hotels in Villadepera
If you are looking for Villadepera hotels in a particular area, you can use the search feature at the top of the page to search by neighborhood, landmark, address or zip code, or you can search by using the built-in map feature. You can also browse hotels in Villadepera by type, amenities, and star-rating so that you can find the best hotel. Currently, top rated hotels in Villadepera are:
- Hotel de Alba
- Parador de Zamora
- Centro de Turismo Rural Lajafriz
- Posada Real La Mula de los Arribes
- Estalagem Santa Catarina
The location of your Villadepera hotel is important. If you are traveling to Villadepera, &StateorCountry for business, you may want to consider getting a hotel close to the airport or near your meeting venue. By doing so, you can really cut down on transportation costs and time. You may also want to book a hotel that offers free wifi just in case you need to get some work done.
If you are traveling for vacation, figure out which attractions or landmarks you want to see and book a hotel that is within close proximity. Although hotels near attractions might cost a little more, you may find that spending those extra few dollars is worth the convenience. You can even find hotels that align with your interests. For example, if you are looking for a relaxing vacation, a spa hotel may be the perfect choice for you.
You'll also want to determine which type of accommodations will suit your needs before booking a hotel in Villadepera. If you're traveling with the kiddos, a family friendly hotel will offer larger rooms and more sleeping arrangements. For those traveling for an extended period of time, booking a hotel suite with a kitchenette is a smart move and will feel a little more like home. If you are budget conscience and just need a place to rest your head, a hostel or motel may be all you need.
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Before you book, check out user reviews. Hotels.com has 0 reviews in Villadepera. We show reviews from Expedia and TripAdvisor so you know that you are reading genuine, reliable reviews. Be sure to download the Hotels.com app so you can book your reservations on the go, view amenities, and save the hotels you want to view and compare later.


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Doctor insights on:
Guinea Pig Pain When Defecating
Did it ever occurred to anyone taking experimental drugs that you may be a human guinea pig?
That's true: Yes, there are risks with experimentation.Get a more detailed answer ›
I fell 2 weeks ago.I fell into a metal Guinea pig cage.The metal bar broke-through my cotton pants & broke my skin.Tetnusshot4-5yrs ago.do i neednew1?
No.: Tetanus vaccine good for 10 yearsGet a more detailed answer ›
My grandson has guinea pig and has the cage in his bedroom where he sleeps. Is there any health risks involved by having the cage in the room?
Pets and Disease: Nope. As long as he is healthy there is nothing to worry about. ...Read more
Sudden guinea pig allergies or is their chow?
Probably GP: A furred animals can cause allergies. Given the choice between the animal and the chow, the best guess would be the animal. ...Read more
Should I be tested for having guinea pig allergies?
If you ask, then yes: People may be allergic either to their dander (not hair) and/or urine (which is common), or to their bedding itself, or something else. If the history does not make clear which this is, an allergist can do skin testing, and also advise you whether there are ways in which you can keep a beloved companion animal despite an allergy. Good luck. ...Read more
Can you tell me how I could help my allergies to my guinea pig?
Guinea pig: Allergies to pets are common, see an allergist and get tested and ask about allergen immunotherapy ...Read more
Are rodent allergies the same as guinea pig allergies?
Yes: Guinea pigs are part of the rodent family and they can all produce similar symptoms. ...Read more
Does guinea pig allergies mean I cannot eat rabbit?
I'm not sure but is: Your diet that exotic? Wow.Get a more detailed answer ›
Is there any way that I can get rid of my guinea pig allergies without giving it away?
Possibly: If it is truly the guinea pig that you are allergic to, you can consider doing allergy injections to decrease your symptoms. I usually don't do this in my practice, since it would be much simpler to consider another pet. Remember that you may also have symptoms with the wood shavings in the cage or other allergens. Talk with an allergist to find out more. ...Read more
If a young child had a guinea pig who had mycoplasma, could that be passed on to the child?
Mycoplasma: Mycoplasma is usually spread by droplet infection if your child is playing with an infected guinea pig, and does not wash his hands well after the play, he could develop a mycoplasma infection. Tell him not to bring his hands to his mouth without washing well. ...Read more
- Talk to a doctor live online for free
- Pain under right shoulder blade when taking a deep breath
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- Ask a doctor a question free online
- Pain in throat when yawning
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- Belly button pain when urinating
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|Kids & Family
Fun videos to inspire, intrigue and stir your imagination from some of the world's leading thinkers and doers onstage at the TED conference, TEDx events and partner events around the world. You can also download these and many other videos free on TED.com, with an interactive English transcript and subtitles in up to 80 languages. TED is a nonprofit devoted to Ideas Worth Spreading.
October 31st, 2012
Episode 22 of 136 episodes
In Western society, bats are often characterized as creepy, even evil. Zoologist Emma Teeling encourages us to rethink our attitude toward bats, whose unique and fascinating biology gives us insight into our own genetic makeup. (Filmed at TEDxDublin.)
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Have you trembled 'round the campfire as the ghost stories are told? Do tales of horrors wrought by nature and beyond strike fear in your soul? Is it best when you are afraid to turn out the light? Thrill to stories that strike at your deepest fears, as host Stephen Kilpatrick brings the best of horror fiction to your ears and your mind, read to you by the most chilling narrators that podcasting has to offer.

 Podcasting the finest in genre fiction, Tales to Terrify is where the depths of horror reveal the truths of good, evil, and the human spirit in the District of Wonders podcast network. Like all shows in the District of Wonders, Tales to Terrify is supported by a welcoming community of dedicated fans and contributors. Subscribe today, and begin your journey through the spine-tingling depths of storytelling.

 Everyone has a story in the District of Wonders. Come and find yours.


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Cell Phone Store
Computer Repair Service
Electronics Repair Shop
I have to admit, I would not expect this level of service from a cell phone repair shop, but these guys are awesome. They definitely exceeded my expectations.Yazmin
- Internal and External Wireless Repair for mobile phones and tablets of all models, including Apple iPhone & iPad, Samsung Galaxy, LG, and others.
- Certified, On Site Technician can work within any operating system, such as Apple iOS or Google Android.
- Screen Replacement
- Water Damage Repair
- LCD & Digitizer Replacement
- Data Transfer & Recovery for contacts, photos, SMS, video/audio files, ringtones, and more!


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We work closely with the best local tour operators across Latin America, each of whom specialises in providing a range of services in one country or area. Our longstanding relationships with these carefully selected local partners, many of whom we've worked with for decades, allow us to have complete trust in the services they provide on the ground. If you're travelling on one of our Tailor-made Holidays or Private Journeys, they will be there to meet you at the airport, provide your transportation, take you on the excursions that you've booked with us and check you in at your hotels.
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It was a big night for senior D'Angelo Hansbro, as his team-high 32 points led Romulus (11-4) to a 64-45 victory over Detroit Country Day in a non-conference boys basketball game Tuesday night.
Hansbro's game also was one for the record books. He set a school record with 10 3-pointers, including six in the first half alone.
"It felt great being able to make most of my shots, and once I got into a rhythm early on, almost everything was going in," Hansbro said.
Romulus coach Jerret Smith said Hansbro was the difference.
"He helped out a lot tonight. As the game went on whenever he had the ball he was dangerous," Smith said. "If he had the chance to shoot, he took it."
Country Day Coach Mark Bray said Hansbro seemed unstoppable.
"There wasn't a lot we could do to stop him,'' Bray said. "He made shots when it mattered, and he definitely made it tough for us.
"He was fantastic, and I give him a lot of credit."
Romulus took command of the game in the second quarter after a 17-11 lead after the first. Big shots and great defending helped increase the lead and pushed the final score to almost a 20-point margin.
Sophomore Rahsaan Pope added nine points for Romulus.
"On both sides of the ball, we played really well," Smith said. "It was a great all-around effort by the boys."
Detroit Country Day (4-11) stayed close to Romulus in the first half, trailing by only six at one point, before Romulus put the game away in the second half.
"Shooting was just something that we couldn't do as well as our opponents," Bray said. "We also were having a hard time containing their passing game, which led to a lot of their outside shooting."
Sophomores Kolin Demens and Ashton Franklin were in double figures with 19 and 10, respectively, to lead Country Day, while junior Paul Mocur also chipped in with eight.
"This is a game that we'll have to look at as a learning curve for the boys," Bray said. "Just need to learn from our mistakes and not have them happen as much in our next game."
Romulus will look to continue to keep the momentum going on the road at Indianapolis Cathedral on Saturday night. Detroit Country Day will look to bounce back as it travels to Grand Rapids Northpointe Christian also on Saturday night.
"We know our next game is pretty far from here, so we might have some weary players once we get there," Oats said. "But we'll get going straight away with our gameplan and hope to come back home with a win."


text:
The three entrants into the SN Hall of Fame for 2011 were all pioneers in their own way — Robert Aders as the first president and chief executive officer of Food Marketing Institute, Joseph Albertson as the founder of the Albertsons chain and Ralph Ketner as one of the founders of Food Lion. A former Kroger executive, Aders already had a long history of industry, government and association experience when he was tapped to be the first leader of FMI. His low-key management style and ...
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MRP: Rs. 69.50 for 1 strip(s) (10 tablets each)
Report Error
Composition for TIGATELTiagabine(4 mg)
food interaction for TIGATEL
alcohol interaction for TIGATEL
pregnancy interaction for TIGATEL
lactation interaction for TIGATEL
It is better to take Tigatel 4mg tablet with food.
Tigatel 4mg tablet may cause excessive drowsiness and calmness with alcohol.
Tigatel 4mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.
SALT INFORMATION for TIGATELTiagabine(4 mg)
Tigatel 4mg tablet is used in combination with other medicines to control partial epileptic seizures (fits) (electrical signal abnormality affecting a part of brain).
How it works
Tigatel 4mg tablet belongs to class of medications called as antiepileptics. It works by increasing the levels of Gamma amino butyric acid (GABA), a natural inhibitory brain chemical that control transmission of signals and thus prevent transmission of abnormal signals causing seizures.
Common side effects
Nervousness, Abdominal pain, Aggression, Walking difficulties, Altered speech, Balance disorder (loss of balance), Blurred vision, Depression, Diarrhoea, Dizziness, Hostility, Impaired concentration, Insomnia, Nausea, Tremor, Vomiting, Fatigue
SUBSTITUTES for TIGATELNo substitutes found
Expert advice for TIGATEL
- Inform your doctor before taking tiagabine if you have mild to moderate liver disorders or intolerance to some sugars.
- Consult your doctor if you notice increase in the number and severity of seizures, appearance of skin rashes, pimples or blisters, anxiety, depression or visual disorders.
- Do not drive a vehicle or operate heavy machinery after taking this drug as it may cause dizziness, sleepiness or tiredness.
- Do not stop the treatment with tiagabine without consulting your doctor as it may lead to recurrence of seizures.
- Inform your doctor before taking the drug if you are pregnant, planning to become pregnant or breastfeeding.


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Ticket to Jerome Brown BBQ Cook-Off & Music Festival
Metropolitan Park • Jacksonville, FL
Saturday, August 30
What you get
- $18 ($25 Value) for One General Admission Ticket
- Sample BBQ from More than 20 Amazing Teams! (3 to 5 P.M.)
- Live Music Headlined by Grammy Nominee Najee & Many More
For more than 25 years, Jerome Browne Barbecue has been serving up mouthwatering dishes, sauces, and more. Now, get ready to have your taste buds dazzled at The Inaugural Jerome Brown BBQ Cook-Off and Music Festival. Held on Saturday, August 30 at Metropolitan Park, this flavorful, family-friendly festival features live music from a host of talented artists including Grammy-nominee Najee, Kurtis Blow, J. Collins, Katz Downstairs, B. DeVine, Stephen Carey, Mondo Mike, and more.
In between checking out all the great music, step right up and watch as local and regional barbecue teams battle against one another in the BBQ Cook-Off Competition. They've traveled from far and wide with their signature recipes; now, it's time to see who will be crowned champion. Even better, you'll be able to sample barbecue from the 20-plus competitors from 3 to 5 p.m. -- and vote for your favorites to take home the People's Choice Award. Plus, the popular, local Gun 'N Hoses organization will be on hand as firefighters and police offers square off in their own cook-off challenge.
Jerome Brown BBQ Cook-Off and Music Festival's Website
Fine printREFUND POLICY: This event is nonrefundable. No full or partial refunds are given to customers who miss an event. In the event of a cancellation, your voucher will be fully refunded • Limit 5 vouchers per purchaser, up to 5 additional as gifts • Each voucher is good for 1 person • The deal is valid only for tickets on the date[s] of the event as listed and may not be exchanged or redeemed for any other dates • Entire value must be used in a single visit
Other conditions apply
Except where noted in the fine print:
• Cannot be combined with any other offer or promotion
• Tax and gratuity are not included
• Merchant is responsible for the quality of the products or services provided to you at redemption
• LivingSocial Terms and Conditions - https://m.livingsocial.com/terms
Ticket to Jerome Brown BBQ Cook-Off & Music Festival
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i'm only sixteen and i have a lump (that keeps growing larger) on my testes...its a little swollen and the viens around it are darker then usual...it also hurts sometimes....it looks like it could be a build up of puss or something...or even worst i'm afraid its cancer...i'm afraid to tell my mom cuz that would be EMBARRASSING...could someone please tell me what it is and how i could get rid of it.....????Reply Follow This Thread Stop Following This Thread Flag this Discussion
Know the five types of psoriasis and how to spot flares.
Newer diabetes treatments can suppress appetite and aid weight loss.
Try these tips to get your salivary glands back into action.
Constipation is a common side effect of opioid and narcotic pain medicines.
Is it sensitive skin or something else?