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This is a fun conversation on my Grapplearts Radio Podcast about BJJ, Judo and MMA with Jeff Meszaros. Jeff is one of the guys that I first started training in BJJ with 23 years ago. The conversation goes off the rails a number of times, but here's some of what we covered... Self defense applications of BJJ Russian team MMA events Judo, BJJ and the early days of the Uncle Willy's … [Read more...]
The Training and Competition Strategies of Bernardo Faria
Bernardo Faria is a 5 x BJJ World Champion (and a good friend) so I was very excited to sit down with him and have an in-depth conversation about his competition, training and conditioning routine. The full transcript, audio and video are below on this page, but here's a quick preview of some of the things talked about: Exactly what a world champion's day to day training regimen … [Read more...]
Grapplearts Radio Podcast Episode 40: Stephan Kesting and Ritchie Yip
In the 40th episode of the Grapplearts Radio Podcast Ritchie and I start with a discussion of Darth Vader's lightsabre technique in Rogue One and then go deeply into the topic of paralysis by analysis in jiu-jitsu, teaching technique, the best way to train to get good fast, and many other fun topics. We finish up by talking about areas that we've focussed on in our own training this … [Read more...]
BJJ Q&A Podcast with Rob Biernacki
There's a new Grapplearts Radio podcast out!! I recently brought Rob Biernacki - a BJJ black belt and the creator of the highly reviewed BJJ Formula apps - back into the studio for his second appearance on the Grapplearts Radio Podcast... We mostly did a Q&A format in which we answered reader questions about everything from passing the guard to organising your training, but we also went … [Read more...]
Kurt Osiander Interview – the Barbarian of Brazilian Jiu-Jitsu
I've just released the latest podcast (episode 35), featuring an interview with Mr Kurt Osiander. Kurt is an old-school BJJ black belt under Ralph Gracie. He's known for his no BS communication style, his informative Youtube instructional videos, and his swearing (this interview is definitely not for the ears of little children or the overly sensitive). The topics we cover include... … [Read more...]
Podcast EP 34: Brazilian Jiu-Jitsu Principles with Rob Biernacki (plus Ninjas, Insane Martial Arts Instructors and Martial Arts Cults)
The latest episode of the Grapplearts Radio Podcast is out. In it I talk with Rob Biernacki, a friend, BJJ black belt, and contributor to Grapplearts (see the videos and articles he's been involved with here). Rob is known for his analytical style of teaching BJJ. He doesn't focus on being a 'technique collector, but rather specialises in sharing the underlying principles and concepts that … [Read more...]
Podcast EP33: Leglocks with Eddie 'Wolverine' Cummings
In this episode of Grapplearts Radio I quiz Eddie Cummings - one of the very best leglock artists active on the competition scene today - about every detail of his leglock game, including : Why the heel hook is one of the most efficient submissions for self defense How to train leglocks safely How a world class grappling competitor spends his days Dead ends and rabbit holes that … [Read more...]
Podcast EP32: BJJ and Self Defense, with Jeff Rockwell and Stephan Kesting
Direct from Isla Mujeres, Mexico, here's my latest podcast interview. In it BJJ black belt Jeff Rockwell and I discuss: How certain techniques are 'discovered' again and again What are 'the basics' and why you need one tool for every range Self defense vs competition jiu-jitsu When butt flopping in a self defense situation is the RIGHT thing to do Hair grab defenses for women The … [Read more...]
Podcast EP31: BJJ Sports Psychology with Gustavo Dantas
It's one thing to lose in BJJ competition if your opponent really is better than you. But it's quite another to be beaten by an opponent that you KNOW you're better than... to underperform... not to live up to your potential. It sucks! The most common reason for losing to someone with lesser jiu-jitsu skills is that you psyched yourself out and lost the match mentally. You can be in top … [Read more...]
The de la Riva Guard
By Don Whitefield and Stephan Kesting We asked BJJ legend Ricardo de la Riva to show us the Five Most Imporant Techniques from the 'de la Riva Guard! Here's what he showed us, and we'll go through each one of them! The Basic de la Riva Sweep The Reverse de la Riva Sweep The Entangled Leg Sweep The Back Trip Sweep The Cross Knee Guard Pass Counter Ricardo de la Riva is a slight … [Read more...]
Podcast EP29: Skepticism and the Martial Arts
Skepticism is your best defense against the lies, hoaxes and magical thinking that are so rampant in the traditional martial arts. Join us on this Grapplearts Radio interview where I talk with Jeff Westfall about chi, the evolution of kata, insane martial arts teachers, Indonesian Silat counters to BJJ submissions, the chimpanzee brain, the fight or flight reflex, signs that you might have … [Read more...]
Podcast EP28: How Bernardo Faria Won Double Gold at the BJJ Mundials
In this in-depth interview I talk with Bernardo Faria, the 99kg BJJ fighter who recently took gold in not only his own weight class but also in the absolute division of the 2015 BJJ Mundials. Some of the highlights of my talk with Bernardo Faria included... His mindset going into big tournaments How he developed and refined his highly individual BJJ gameplan What he's learned training … [Read more...]
Podcast EP27: Roxanne Modafferi about MMA Training, Continuing to Improve, Tryouts for The Ultimate Fighter, and More
In this podcast episode I talk with Roxanne Modafferi, MMA fighter and TUF standout, about The differences between MMA training in Japan and the USA, Continuing to improve after 12 years in the sport, Training tweaks that finally snapped a 6 fight losing streak, What tryouts forThe Ultimate Fighter were really like, And much more... You can read, listen to, or download the interview … [Read more...]
Podcast EP26: Perspectives on BJJ Drilling – An Interview with SBG's Steve Whittier
Steve Whittier from SBG East Coast is a cool guy. He manages to combine both thoughtful analyses and controversial opinions into one eloquent package. In this interview we talked about lots of different BJJ and MMA related topics, but the main emphasis and recurring theme was functional drilling and the efficacy of different types of BJJ training methods but we also covered self defense vs. … [Read more...]
Podcast EP25: BJJ Beginner Tips Interview and Podcast
In this Grapplearts interview I talk to BJJ Black Belt Ritchie Yip, focusing on tips that BJJ beginners need to know. But sometimes the conversation goes a little off track! You can follow/consume/download/watch this awesome and informative interview several different ways... You can watch the Youtube video below You can download the mp3 file by right clicking here and selecting 'Save … [Read more...]
Podcast EP23: Brandon 'Wolverine' Mullins on BJJ Training, Competition, Transitions and Evolution
I've got a super cool, super informative interview for you today! This is the first time in Grapplearts history that I've interviewed a person for a second time. But boy, did my friend, BJJ black belt, and fierce competitor Brandon 'Wolverine' Mullins ever deliver! (click here for the first interview). (Brandon and I originally worked together to create the highly acclaimed instructional … [Read more...]
Podcast EP22: Adam Singer on Modern MMA Training and Competition
Stephan: I'm here today with my friend, Adam Singer, who runs The HardCore Gym in Athens, Georgia. He is probably best known for being Forrest Griffin's MMA coach during the formative years of Forrest's career. He's also a jiu-jitsu black belt and has trained tons of fighters. I'm really looking forward to picking his brain about MMA and jiu-jitsu and the relationship between these things. … [Read more...]
Podcast EP21: The Evolution of BJJ (Plus Some Crazy Stories) with Scott Nelson
We've just released the latest episode of the Grapplearts Radio Podcast! This time I talk to Scott Nelson from On The Mat. Scott is a North American jiu-jitsu pioneer who was one of the very first guys to travel to Brazil to train in the motherland of the art. He was also one of the first guys to run a Brazilian Jiu-Jitsu website (I remember visiting it back in the dial-up modem … [Read more...]
Podcast EP20: The Art and Science of Teaching Martial Arts
I recently interviewed my friend, training partner, black belt, and school owner Ritchie Yip. The main theme of our discussion was the art and science of teaching martial arts, including how to teach students with different learning styles and experience levels. Not every student learns the same way, and a good teacher knows how to adapt his material and curriculum to help students of all learning … [Read more...]
Podcast EP19: Clark Gracie on Training, Competing, and Growing up Gracie
This is a great interview with 2013 Pan Am BJJ Champion Clark Gracie. He shares a ton of cool info. You can listen to, read, or download this interview in several different ways… Play the audio-only Youtube video at the bottom of this list, and/or Right click on this link and select 'save as' to download this mp3 file to your computer, and/or Subscribe to the Grapplearts Podcast in … [Read more...]


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Fishing Jigz with the Z Man
BatwingZ Trailers
are one of my absolute favorite baits to throw. I've paired my jigs up with
several types of trailers over the years, but they don't always last very long
or stay on the hook very well. From a durability standpoint, the Z Man BatwingZ
trailers look like they should have no problems withstanding a lot of abuse. I
grabbed some new jigs and a bag of these trailers and hit the water to find out
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If there's one little niche
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I mentioned this in conversation with St. Croix's president, Paul Schluter, and he asked me if I've seen their Legend Trek series. I had not.
Kistler's New Flagship ZBone LEXF Casting Rod
Once only available as a custom, made to order rod, the ZBone is now available in several stock builds. For our review, we're taking a closer look at their Search for One candidate in the LEXF-3MH-70, a seven foot (7'-0") stick built on a North Fork Composites HM Graphite blank.
Re-Energizing Their Drive : Denali's New Lithium Mag Crank Stick
With the emergence of the L.O.U.S. (lures of unusual size) syndrome, rod manufacturers are busy cranking out sticks (pun intended) that can launch these oversized plugs over the next breakline. Today, we take a look at one such product from a manufacturer ready to break out of the pack and distinguish themselves. Introducing Denali's Lithium L945XD...
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Whether you live in the city or the suburbs, your lifestyle isn't that different when it comes to choosing a professional waste control company to provide you with reliable garbage pickup in Corning. What matters is receiving reliable garbage pickup in Corning that's simple, effective and environmentally sound, with a variety of permanent and temporary solid waste and recycling services from Casella! You are only one call away to receive Casella's garbage pickup in Corning and help in the process of turning the everyday products we use into energy resources instead!
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This paper characterizes the aspects of exchangeability in the Shapley value. We show that, in the Shapley value, each player's prospects of joining a t-player game as the last member of the game is a moment sequence of the uniform distribution. We prove that, with finite exchangeability, the Shapley value is the only value in which the probability… (More)
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This video is an introduction to finding the radius, diameter, and circumference of a circle. It is also an introduction to pi.
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St Matthews Hospital, 21/23 St Matthews Parade, Northampton NN2 7HF
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100 Days of Climate: Week 6
Addressing climate change using sound science is crucial not just for the U.S., but for the world. Unfortunately, that appears unlikely over the next four years under the Trump administration, which has shown signs of being apathetic if not outright hostile to climate science and science-based policies to rein in carbon pollution. Trump has… Read More
The U.S. is Poised to Set a Record-Setting Record
California's biblical deluge has occupied many a meteorologists' mind this February. But another notable story is unfolding across the eastern U.S. Unseasonable warmth has kickstarted spring up to a month early in the Southeast, cut into already paltry Great Lakes ice cover and created skiing conditions more reminiscent of April in the Northeast … Read More
Scientists Got a New Look at the Growing Larsen C Crack
It's summer in Antarctica, which has scientists scurrying around the seventh continent carrying out various research experiments. That includes monitoring the massive crack that has spread across the Larsen C ice shelf, located on the Antarctic Peninsula. On Tuesday, researchers with the British Antarctic Survey released new aerial footage showing… Read More
Humans Are Changing Climate Faster Than Natural Forces
For the first time, researchers have developed a mathematical equation to describe the impact of human activity on the earth, finding people are causing the climate to change 170 times faster than natural forces. The equation was developed in conjunction with Professor Will Steffen, a climate change expert and researcher at the Australian National… Read More
California Farmers Use Floodwater to Replenish Aquifers
As dam managers were draining water from a Northern Californian reservoir this week to avert what could have been one of the worst flood disasters in the state's history, Southern California farmer Don Cameron was doing something different with the watery winter excess. Using a network of levees and irrigation gates, Cameron inundated the orchards… Read More
This January Was the Third Warmest on Record Globally
While a powerful El Niño has faded, the globe's heat continues to be an enduring phenomenon due largely to carbon pollution. This January was the third-warmest January on record, according to data released this week from both NASA and the National Oceanic and Atmospheric Administration. The agencies use different baselines and techniques to … Read More
Antarctica Just Shed a Manhattan-Sized Chunk of Ice
The growing crack in the Larsen C ice shelf is the most dramatic example of change in Antarctica right now. But it isn't the continent's only frozen feature changing in a warming world. Ice around the continent is disappearing as the air and water heat up and the less dramatic breakdowns are just as important to understanding the fate of the ice … Read More
Congress Protects Coasts From Climate Change With Mud
As California reels from record-breaking erosion following punishing waves last winter, the federal government is turning to mud and sand from dredging projects to slow land losses and ease flooding nationwide as seas rise and storms intensify. Pacific Ocean storms strengthened by a powerful El Niño and global warming caused yawning erosion from … Read More


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Introduce into your kitchen this simple yet effective Bajaj GX-7 Mixer Grinder for day to day activities that involve grinding, liquidising, and mixing of food ingredients. It comes with three jars that serve different uses such as the mixing and liquidising jar, the wet and dry grinding jar, and the chutney jar. These stainless steel jars of different capacities are useful for grinding raw spices and other vegetables. The grinder is equipped with a three speed controls where you can choose three different settings as per your requirements. The jars are fitted with multifunctional blades for whipping and mixing. The Bajaj mixer grinder is built with a motor overload protector to prevent any wastage. A spatula is included as well for mixing of batter or easy removal of the blades. The jars are well designed and their lids snap on tight enough to avoid any food spillage. It is a sturdy and durable device which can be used to grind, mix, and stir a number of ingredients. The Bajaj mixer grinder is built for sturdiness and maximum output with the help of high quality blades and stainless steel jars. Bajaj is also offering a warranty of 24 months on the life of the product and of 60 months on the motor. You can buy this appliance at a budget-friendly price at Snapdeal.
3 Stainless Steel Jars with PP Lids
The Bajaj GX-7 Mixer Grinder comes with three jars that let you take care of a number of tasks of different quantity. These jars are made of good quality stainless steel that ensures quality and durability of the product. The liquidising jar has a capacity of 1.5 litres and features an ergonomic handle. The chutney jar or the masala grinding jar has the capacity of 400 ml that allows you to mix or grind all sorts of spices. The dry and wet grinding jar has a capacity of 1 litre and it also comes with a handle. All the jars are provided with flat PP lids that get attached to the jars tightly and prevent spilling over of the contents.
Super Sharp Blades
This Bajaj GX-7 Mixer Grinder comes with razor sharp blades that can conveniently take care of a number of tasks like chopping, mincing, grinding, mixing and more without any hassle. The multi-function blade system works effortlessly and can mince and cut a variety of fruit and vegetable in very less time.
Power Consumption
This mixer grinder from the popular brand Bajaj has a power consumption of 500 watts and an operating voltage requirement of 220-240 V. In addition, it comes with the motor overload feature, which prevents the device from getting over-heated and also ensures safety.
Safety Features
The auto shut off feature of this Bajaj GX-7 Mixer Grinder automatically shuts down the device in case of any power fluctuation or any other fault. The safety lock allows the jars to get fixed to the device properly, preventing any accident that may occur when the device is working. The built-in motor protector prevents the motor from getting over-heated.
Anti-Skid Feet
The Bajaj GX-7 Mixer Grinder has rubber stoppers at the bottom which provide stability over a number of surfaces, thus preventing it from toppling over. This also prevents any sort of accident that might occur while the device is running.
Rust Proof Plastic Body
The Bajaj GX-7 Mixer Grinder has a compact design owing to which it can be conveniently stored on any kitchen shelf or a cabinet without any hassle. The main unit is made of fine quality ABS plastic that is rust-proof as well as shock-proof. This white coloured mixer has an ergonomic design and comes with easy to use knobs and buttons. In addition, the leak-proof design prevents leakage and ensures safety while using it.
Powerful Motor
The Bajaj GX-7 Mixer Grinder is built with a high powered motor with 18000 RPM. The three speed element comes with an incher facility which offers a pulse feature for whipping, and it can be used to make creamy beverages.


text: Jobs Opportunity in Federal Shariat Court of Pakistan 2016: Application are invited from Suitable Candidates for the Following 14 Vacant Posts. Librarian, Judicial Assistant, Accounts Assistant, Stenographer, Assistant, Stenotypist. Application Submission Deadline is 13th Nov 2016. For further information, please visit website Click Here or call 051-8444441. This advertisement published in daily Jang newspaper on 29th Oct 2016. Male/Female Jobs Available in Federal Shariat Court of Pakistan.


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myrtha35 wrote:Tried to pay this month's bill somehow payed it and next months and not knowing I made any type of payment I made another payment for this month like I intended to . So I have two payments ne wanted ,intentional payment(137) and one unwanted , unintentional payment(281) for this month and next and even despite their system that should allowsuch 2 payments to be made within a w24 hour period. I want my 281 back.
Look on the bright side, you won't have a cell phone bill for the next couple of months!
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The black haired beauty looks amazing in that pink lace dress so it's no wonder this guy wants to fuck her. However it's the first date and he doesn't really figure he has a chance if he uses conventional methods. She doesn't seem like a slut so he'll have to take her out at least three or four more times before he gets in her pants. This is the exact reason he bought the date rape drug. He gets up to get them each a glass of wine and he pours a little of it into her drink. They toast and she drinks about half of it before her head starts spinning and she passes out. He's excited when she's finally gone and he starts using her body like his personal playground. He licks her tits, fingers her pussy and then whips out his cock and forces it into her mouth. He gets a great blowjob and then lets her on her stomach and fucks her hot pussy from behind while she rests.
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some one who got a lot of pussy in one night
damn man i was the va j j killer last night
by mwhite bloodz October 04, 2007
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It has got to be better than Wayne Rooney scowling and spitting. After the predictable demise of England at the Euros, Heather Watson's ebullient smile briefly brightened up our damp, grey summer. The Guernsey girl, who became the first British woman in a decade to reach the third round at Wimbledon, is well on the way to supplanting the Jersey boy Bergerac as our favourite Channel Islander. Give that girl a cigar, Charlie Hungerford.
As John Inverdale wittered on Today at Wimbledon (BBC2, Wednesday): "In this Olympic year of all years, we keep talking about how sport is for inspiring young people and having fun and just getting out there on the big stage. Nobody seems to do that more than Heather Watson." A few more years on the circuit should wipe that smile off her face, though.
Contrast with Maria Sharapova, "six-foot two, super intense, ready to bear down," according to Sam Smith. When a point goes against her, she looks like a character in a BBC period drama who has suffered the most grievous insult from a prospective suitor. "If ever there was a look that turned water to ice, Sharapova just delivered it," said a wary Nick Mullins during her struggle with Tsvetana Pironkova.
The BBC's highlights package seemed to get its frilly knickers in a twist during the first week. Anne Keothavong was 5-2 up in the second set on Tuesday evening but the Beeb went straight to Inverdale instead. Nor did they show any highlights of Murray's first-round match because apparently we had all watched it already.
By the next day they seemed to have changed their tune. "The point of this programme is that people go to work," breathed Inverdale, whereupon instead of allowing us to catch up on the day's events they took us off to watch Sharapova live for half the show. But it's on the red button, we screeched, Maria-style.
Then we were treated to the resumption of a match between Coco Vanderweghe and Sara Errani which had been poised on match point overnight. After 15 minutes of warming up, the action lasted seven seconds – Vanderweghe served a double fault, and that was that. At least they didn't show the whole warm-up.
John McEnroe is invariably the best thing about Wimbledon coverage but he failed to show up for the highlights on Wednesday, and the previous evening Mac appeared in a Mac to take away the umbrellas of Inverdale, Tracy Austin and Boris Becker before disappearing again. He's been very generous with his time in the past, so perhaps he's finally had enough and decided there is something intrinsically wet about British tennis. Fair enough, you're bound to get soaked at some stage.
No wonder the players like to have a towel handy. Watson is one of the leading towel-users in the game, but unlike most Brits she just wants to wipe the sweat off rather than put it over her head and sulk.
There was, in fact, no escaping the football. Some overtired and emotional fans had set up on Court 14 to cheer on Jamie Ward in a most downbeat fashion. It was a five-setter, so perhaps they had been a little more animated earlier on. But it might be better to hire the Tartan Army to come down and help out. After all, they haven't been up to much this summer.Reuse content


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Yesterday, Stella Damasus shared her view about the controversial statement Pastor Adeboye made. Some of her fans still can't believe she claims to be a feminist and an activist especially when she is dating another woman's husband.
Check out a fan that made a comment on her post on Instagram and guess what, Stella won't stop amazing us by her reaction to such people. Read the conversation below:


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You watch as a blue eyed girl walked down the hallway, head down doing her best to go unnoticed when a certain black haired bully approached her. Zane walked up to the blond haired girl and pushed her down.
Stepping out in the middle of the hallway you exclaim, "Hey pick on someone your own size!"
Zane leaves the poor girl alone but not before sending you a nasty glare. Brat
You quickly ran over to the girl and spoke in your kindest voice. It's not that kind but it'll have to do
"Are you okay?"
" Y-yes." She manages to stutter out.
"It's okay I'm not here to hurt you." She gave you a surprised look as her blue eyes look like she'd just seen Irene herself. Irene, how lonely is this girl?
"R-really?" She asks still surprised.
"Yes." You reply without hesitation. Maybe I'll make a friend, for once...
"Well then I'm Emmalyn and I'm new." She says suddenly gaining a bit of confidence.
"I can tell." You say smiling. Why the fuck am I smiling?
"I'm y/n." And with that a new friendship was born.
I'm Going To Attempt To Edit And Complete This Story Like A good Person. ;~;
IceyThe2ndx3 Aug 01, 2016
Lol I would probably jump thru the screen and chase after u xD
LizzyRomeave Aug 27, 2016
It'd kind of weird for me...... I LOVE MY BROTHER HEHEHEHEHE
Heichous_Demon_Wife Sep 12, 2016
it's mr. Godzilla. plz don't stomp on me if I don't turn I my homework
ShadowYuki Aug 12, 2016
* Grabs writer and slaps him/her till they pass out and walks off *
hisnameissusan Oct 27, 2016
Forget this im going to another story MOST LIKELY A.....Maybe A Yaoi
PinkyDerperz Dec 04, 2016
First of all this character is exactly like me Second of all COME OVER HERE AUTHOR~CHAN IM GONNA MURDER YOUUU


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Spectators will be able to see high school athletes from all across the nation battle in his/her event(s), and perform to his/her fullest capability. Participating in the meet itself is gratifying because it takes great effort, talent, and dedication to compete on this level.
To be able to participate in the adidas Outdoor Championships you/your relay must be eligible. You have to be eligible by meeting the guidelines and qualifying standards. The qualifying standards are on the AOC website.
The meet starts Friday June 18 at 4 p.m. with the discus and track competition begins at 5 p.m. with the one mile racewalk. The first day of action concludes with the 4x200 meter relay. Saturday the meet will begin at 8:30 a.m. with the 4x1 mile relay. The field events start at 11 a.m. Saturday.
In this meet, there will be many athletes from South Carolina. These athletes include: Dominick Bailey, Richard Williams, Rodney Lipscomb, Michael Rhue, Dmitri Virnig, Toma Walker, Dex Badgett, Andre Gladness, Andrew Gladness, Jonathan Chu, David Huckaby, Whitney Charles, Jessica Young, Polly Hardy, Brittney James, Nyoka Norman, Erica Adams, Myra Hawkins, Tempest Vance, Latricia Jones, Angelina Blackmon and Kate Niehaus, as well as many others.
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June 19-July 14, 2017
Every summer, the Bay Area Center for Waldorf Teacher Training offers a number of professional development and renewal through the arts programs open to the greater Waldorf community and the public. Please check back soon for additional courses!
For more information, please contact email@example.com.
To register, please send a check to BACWTT (P.O. Box 21265, El Sobrante, CA 94820) and indicate the course(s) in which you would like to enroll. To pay with credit card, please click on the title of the course(s) below:
- Waldorf Teacher Rejuvenation (June 26-30, 2017)
- Teacher Training Taster (July 5-7, 2017)


text:
Ok so I just have a question. We are renting our house out, it's our first time doing this and I just have a question.
We are going through a realestate so hopefully it'll be painless, but they've just asked if we are willing for the lady to pay directly from her centrelink payment which then costs us $0.99 a week.
I'm just wondering if anyone knows why the landlords are charged that amount just doesn't seem fair to me, there is no benefit to us for her to pay this way so I see it as the tenant should be paying that not me.
Thanks for any replies


text:
Commercial Trusts in European Private Law (The Common Core
Format: Paperback
Language: English
Format: PDF / Kindle / ePub
Size: 10.58 MB
Downloadable formats: PDF
Pages: 632
Publisher: Cambridge University Press; 1 edition (July 23, 2009)
Engineering and Construction Law & Contracts
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Your chaplain recruiter may also request that a copy be submitted directly to them US Army AWOL Defense: A download epub http://havanarakatan.com/library/us-army-awol-defense-a-practice-guide-and-formbook. Goldline II works well wet or dry, hot or cold. Plied yarn construction substantially reduces the tendency of distortion, tangling or kinking when thrown, uncoiled, or payed out. It also has excellent knotting and splicing qualities. You make a fist; thrust your hand up high, and dozen a United States Marines snap to attention behind you Leadership, Ethics and Law of War http://www.croustiglam.com/lib/leadership-ethics-and-law-of-war. For chaplain candidates, the ecclesiastical approval is simply a certification* that: You are pursuing fulfillment of the requirements for chaplaincy. You are recognized as a member in good standing of the denomination or body. Without approval, you will not be commissioned or appointed to the chaplain candidate program. *Form DD2088 is for ecclesiastical endorsement Nazi Crimes and the Law download for free http://www.croustiglam.com/lib/nazi-crimes-and-the-law-publications-of-the-german-historical-institute. Still more opportunities are available stateside and abroad – onboard a surface ship, working closely with a nearby aircraft squadron, or even with the Fleet Marine Force. Serving part-time as a Reservist, your duties will be carried out during your scheduled drilling and training periods Power Check-Commo Check read for free www.croustiglam.com. Number of bids and bid amounts may be slightly out of date. See each listing for international shipping options and costs. This word doesn't usually appear in our free dictionary, but we've shared just a bit of the information that appears in our premium Unabridged Dictionary Capital Gains Tax Roll-over, download for free download for free. Exclusions: gift cards, delivery services, ag strength chemicals & fertilizers, pet grooming, pallet quantity pricing. Wilco's Military Discount Program is designed to support the men and women who are currently serving our country in the Armed Services(1) and to honor Retired Veterans and VA Recipients(2) , source: Army Techniques Publication download epub http://www.croustiglam.com/lib/army-techniques-publication-atp-5-0-1-army-design-methodology-july-2015.
A Social History of Ancient Ireland. Treating of The Government, Military System, and Law; Religion, Learning, and Art; Trades, Industries, and Commerce; Manners, Customs, and Domestic Life, of the Ancient Irish People (2 Voumes)
My Week at Guantánamo's War Court
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Irish Tax Reports 2008: 2008 Cases, Cumulative Tables and Index (1922-2008)
Global Forum on Transparency and Exchange of Information for Tax Purposes Peer Reviews: Spain 2011: Combined: Phase 1 + Phase 2
Taxation of Employments: Fifteenth Edition
Treatise on Naval Courts Martial (Cambridge Library Collection - Naval and Military History)
The Military Laws of the United States: Relating to the Army, Volunteers, Militia, and to Bounty Lands and Pensions, from the Foundation of the Govern
Law and Development Perspective on International Trade Law
An Immigrant American Hero
The Law of Blockade: As Contained in the Report of Eight Cases Argued and Determined in the High Court of Admiralty On the Blockade of the Coast of Courland, 1854
Dispute Settlement Decisions: Bernan's Annotated Reporter: Decisions Reported: 4 February 2009 - 24 April 2009
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by: Blemma Dreams • 28
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by: Blemma Dreams • 28
SIMEM 3D is three-dimensional version of the classic "Simon Says" game.
SIMEM 3D is easy to play, just follow the sequence rotating the figure and pressing the buttons in the right order.
Rotate the figure moving your finger around the edges of the screen.
* Classic (4 color) mode, plus 6,8,10,12 modes
* Follow Pi mode: always the same sequence, you know 3.1415..........
* Follow e mode: always the same sequence, you know 2.7182..........
* Train your brain while you play!
* Online scoring available thanks to Scoreloop
* Real 3D. Slow on old devices.
3d Engine: JPCT-AE (http://www.jpct.net/jpct-ae/)
Version 1.2
New Sounds.
Now Works on ICS an big screen devices
Some bug fixes.
NOTE: Runs slowly on old devices.
Keywords: simon says clone sequence memory
Tags: o , an3dbenchxl
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text:
Now you are back to products instead of profits. If the government, because it only provides services, is not a part of the GDP, than your owner and the plumber and the electrician aren't a part of the GDP either because all they provide is a service, right?<quoted text>
Maybe you don't. Our company doesn't produce products. An electrician doesn't produce products. Neither does a plumber. It's not production--it's service oriented. Government provides services--not products with perhaps very few exceptions such as NASA or a water plant.
Who do you support for Governor in Ohio in 2010?
Posted in the Cleveland Forum
13,741 - 13,760 of 35,554 Comments Last updated Monday Jan 30
#15047 Dec 8, 2012
#15048 Dec 8, 2012
Well if that ain't a case of the blind leading the stupid I don't know what is. You and Pops are a perfect pair. Dense beyond reclamation.
#15049 Dec 8, 2012
Since you and Pops have both conveniently forgotten Pops' post from last night, here it is,
#15050 Dec 8, 2012
How does "Right to Work" benefit an employer?
#15051 Dec 8, 2012
john,kasich for gov.
#15052 Dec 8, 2012
No threat of a total union takeover. Currently, if a business is unionized, every member must join the union. The only way out is if the union members vote to get rid of a union, and good luck with that one.
RTW gives hope to an industry that eventually, workers will opt to stay away from the union. That saves a lot of money and lessens the likelihood that the employer will have to move to another state to break up the union or out of the country altogether.
#15054 Dec 8, 2012
A much more honest answer than I expected.
#15055 Dec 8, 2012
I've read it several times. Let me give you an example of what he meant:
Bill Clinton signed welfare reform against his own wishes. He also lowered capital gains taxes to help keep the economy moving. Democrats are for welfare people and for higher taxes. He raised taxes in some areas while lowering them in others to get the market going. That's working for the better of our country and not your party alone.
George Bush believed that the wealthy were paying too much tax. He also realized that the economy needed improvements. So he lowered the taxes for everybody--not just the wealthy. He also created the second largest government entitlement in Medicare. Republicans are not for expanding entitlements.
Tell me, what has DumBama done for the better of the country and not his party with the exception of making trade-offs on a few items with Republicans? Nothing. DumBama is a party first-country second President.
#15056 Dec 8, 2012
Thank you.
#15057 Dec 8, 2012
Gross domestic product (GDP) is the market value of all officially recognized final goods and services produced within a country in a given period of time. GDP per capita is often considered an indicator of a country's standard of living;[2][3] GDP per capita is not a measure of personal income (See Standard of living and GDP). Under economic theory, GDP per capita exactly equals the gross domestic income (GDI) per capita (See Gross domestic income).
GDP is related to national accounts, a subject in macroeconomics. GDP is not to be confused with gross national product (GNP) which allocates production based on ownership.
#15058 Dec 8, 2012
That is a Rush Limbaugh retread and nothing more.
#15059 Dec 8, 2012
Fair enough. Answer Rush's question.
#15060 Dec 8, 2012
What has Obama done for the country? Other than reforming health insurance, saving the auto industry, stopping the economic free fall, regulating Wall Street, ending discrimination against homosexuals in the military, signing equal pay legislation, ending the war in Iraq, giving us an outdate from Afghanistan, killing Osama bin Laden, and repairing our standing with the rest of the World? Gee, I don't know.
United States
#15061 Dec 8, 2012
I am beginning to believe that YOU are not only the owner of a mind that is twisted but also entertaining yourself with twisted arguments that resorts to name calling when you have no logic to share.
Let me ask, are you a parent? IF so, your offspring have my sympathies. But that aside, as a parent, YOU represent YOUR family, as a provider, teacher & decision maker, or at least you should.
Does Every decision that you make satisfy or make happy, Everyone in your family? Yet you represent all of them. NOT just your spouse OR your 1st born or 2nd born etc or only the ones of the same gender as you.
Did one of your parents (bless them for putting up with you) represent only one or two of your siblings? OR Did they focus on making only certain family members 'happy' as you put it? Maybe they did & that is the embryo of your mental issues. But they likely 'represented' all of you in their decision making.Unlike Obama & his Minions do for the entire country.
#15062 Dec 8, 2012
So in other words, the POTUS has to exercise his own judgment to do what he believes in in the best interest of the entire nation?
#15064 Dec 8, 2012
Neither retail businesses nor restaurants nor communications providers produce anything either.
And? What the heck is your point?
#15065 Dec 8, 2012
Too bad its flawed.
#15066 Dec 8, 2012
Wrong. Health insurance is up because of Commie Care. That's not for the good of the country. Saving the auto companies (which is debatable) was for his union friends who support his party. Stopping the "free fall" is speculation at best. If anything, his policies have kept this economy stagnant for the last several years.
Gays in the military. Gee, that's not candy for Democrat voters. Definitely no advantage for the country in general. Equal pay legislation only forces companies to pay the same money to less productive workers. No advantage to the country there. If anything, it will only make it more likely for a company to leave the states if they are on the fence about it. Ending the war in Iraq making it a terrorist bed is not in the best interest of our country. It's pandering to his base instead. Giving the terrorists and outdate in Afghanistan only allows them to plan a little better.
Most everything you listed was for the good of himself or his party. I asked what he did to make this country better. You have no real answer. Bin Laden was nothing more than a continuation of Bush and his efforts to find him. Execution without a trial.
#15067 Dec 8, 2012
You better go back and finish your homework. You've left quite a bit out. Read closer next time under "services" and "government spending".
#15068 Dec 8, 2012
Enforced the VRA.
Kept the Country out of a depression, despite GOP obstruction.
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Aug 10, 1999
|Filing date
|Jan 10, 1997
|Priority date
|Jan 10, 1997
|Fee status
|Publication number
|James A. Hayward, David C. Watkins
|Original Assignee
|Collaborative Laboratories, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (38), Non-Patent Citations (2), Referenced by (13), Classifications (17), Legal Events (9)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to enzymes, and more particularly, to an enzymatic composition and system for delivering same whereby long term stability and efficacy of enzymes contained therein may be maintained.
Enzymes are proteins which catalyze specific reactions. The number of different types of reactions that enzymes catalyze is enormous. The extraordinary range and specificity of reactions catalyzed by enzymes has led to their uses in almost all areas of technology, such as agriculture, manufacture of raw materials for the clothing, pharmaceutical and cosmetics industries, for chemical synthesis, etc. Each enzyme shows specificity for a substrate that ranges from fairly general to absolutely specific. For example, trypsin is a generally non-specific enzyme which hydrolyzes the peptide bond between an arginine and another amino acid in almost any protein. An example of a highly specific enzyme is Eco RI, which will hydrolyze the phosphodiester bond between guanidine and adenosine residues in DNA only if they are present in the specific sequence GAATTC. The enzyme (Eco RI) will not work in any other sequence, nor will it work if any of the bases of the sequence have been modified with a methylene group.
Proteolytic enzymes, or proteases, are a class of enzymes which will generally hydrolyze the peptide bond in proteins and thus convert proteins into polypeptides. A large number of proteolytic enzymes is known, each with a different amino acid specificity, e.g., trypsin, papain, subtilisin, interleukin-converting enzyme, collegenase, etc. Many of these proteins have been put to use in various beneficial ways, such as in cosmetic and medicinal formulations, pharmaceuticals, food products, etc. Difficulties in using proteolytic enzymes in such products arise, however, because a good many proteins (e.g., other enzymes) within such cosmetic and medicinal formulations may be affected by the enzyme (e.g., hydrolized by the protease action). Again, all enzymes are proteins the peptide bonds of which are susceptible to hydrolysis by proteolytic enzymes. Accordingly, chemists and/or formulation personnel preparing simple admixtures containing proteolytic enzymes and other active proteins are confronted with the problems associated with hydrolysis of the proteins, and the task of assuring long-term efficacy of the formulations.
The following emphasizes the problem which the present invention addresses. If one wanted a composition of matter which contained both trypsin and scrum albumin, a two container system or separation system would be required to protect the albumin from hydrolysis by the trypsin in the composition. Conventional two-container or microencapsulation systems, however, are difficult to accurately and efficaciously use. That is, they merely reduce or slow the proteolytic activity, i.e., the hydrolytic action of the protease on the non-proteolytic enzyme. Stability, therefore, of compositions of matter containing a protease is possible with conventional encapsulation technology only for the short term.
For example, U.S. Pat. No. 4,668,630 to Louderbach discloses a composition containing at least one enzyme. Substantially all of the one enzyme is combined with a stabilizing amount of reversible inhibitor. The inhibitor forms an inhibitor-enzyme complex thereby stabilizing the enzyme. While such methods reduce proteolysis and result in improved protein or enzyme stability, the efficacy of the proteolytic enzyme is compromised.
Further, U.S. Pat. No. 5,281,356 discloses another example of a two-container encapsulation system provided to separate or minimize interaction between non-compatible enzymes. The system embodies a composition comprising a non-proteolytic enzyme, such as lipase or cellulase, and capsules containing a proteolytic enzyme and a composite emulsion polymer. Were the proteolytic enzyme not encapsulated, its action would degrade the other constituent proteins or non-proteolytic enzymes. The emulsion polymer comprises a hydrophilic portion attached to hydrophobic core particles as a network to entrap the enzymes between the hydrophobic particles and preferably crosslinked water soluble polymer to act like a gel or sieve. The proteolytic enzyme diffusion through the same is thereby slowed, which in turn slows the rate of degradation of the non-proteolytic enzyme thereby. Such a composition, however, does not maintain efficacious separation.
Accordingly, it would be desirable to those skilled in the art to realize a way of formulating and storing a composition containing a fully-active protease with another protein whereby the integrity of the other protein is maintained over time. In particular, a way of formulating and storing a composition of matter including a protease such that the protease is prevented from interacting with other proteins present in the composition. The other proteins, e.g., non-proteolytic enzymes, are therefore protected from proteolytic attack and are therefore present for delivery when necessary.
Further, such a composition of matter or delivery system would be further enhanced were it to include a property which more effectively delivered the active moieties to the surface or object for delivery.
It is therefore an object of the present invention to overcome the limitations of the prior art.
It is another object of the present invention to provide a delivery system or composition of matter which includes proteolytic and non-proteolytic enzymes, and provides for same to co-exist without degradation or hydrolysis of the non-proteolytic enzymes by the proteolytic enzymes.
It is another object of the present invention to prepare a delivery system or composition of matter which includes a combination of a proteolytic enzyme and a glycolitic enzyme in a form of a stable matrix such that the former is prevented form affecting the latter for time periods of a year or more.
It is another object of this invention to create a system or composition of matter in which papain may be maintained in the system with lysozyme such that the papain does not substantially effect the lysozyme unless signaled to do so by a separate mechanism.
It is a further object of the present invention to provide a system or composition of matter which provides for the efficacious maintenance of two non-compatible enzymes as well as an increased affinity of the enzymes for the surface with which they make contact.
FIG. 1 is a plot showing the activity of non-proteolytic enzymes over time in the first and second preparations which include papain as represented by the dashed and solid lines, respectively; and
FIG. 2 is a plot showing the activity of lysozyme over time in the third and fourth preparations which include papain as represented by the dashed and solid lines, respectively.
All enzymes are proteins and therefore susceptible to hydrolysis by proteolytic enzymes or proteases, e.g., papain. Accordingly, simple admixtures of proteolytic and non-proteolytic enzymes tend to have a very limited shelf life due to the natural hydrolytic action of the proteolytic enzyme upon the non-proteolytic enzyme when present.
To remedy this problem, the present invention provides for maintaining separation between proteolytic enzymes and proteins which are normally hydrolyzed by same within a composition or system to ensure extended shelf life of products formed thereby (i.e., sequestering without utilizing protease inhibitors). Separation is accomplished through the use of lipidic bilayer vesicles or liposomes, prepared by any method known to those skilled in the art. In a preferred embodiment, the separation is accomplished through the use of liposomes which display a slightly positive surface charge, or cationic liposomes. Cationic liposomes, referred to interchangeably herein as CATEZOMES™, arc disclosed in commonly owned U.S. patent application Ser. No. 08/594,175, filed Jan. 31, 1996, now U.S. Pat. No. 5,874,101, entitled LIPID VESICLES FORMED WITH ALKYLAMMONIUM FATTY ACID SALTS, and incorporated herein by reference.
The separation of the proteolytic and non-proteolytic enzymes by sequestering the non-proteolytic enzymes within liposomal vesicles for use in a composition of matter or formulation prevents the proteolytic enzymes from hydrolyzing the proteinaceous constituents of the sequestered enzymes. Alternatively, the proteolytic enzymes may be sequestered within liposomal cavities to sequester same from proteinaceous materials present in the extralamellar matrix in which the liposomes are contained.
Liposome sequestration of non-compatible enzymes may be utilized within any composition or formulation system which could benefit from separate storage (before use) of the non-proteolytic enzymes, e.g., sequestration of a non-proteolytic enzyme from a second substance such as a proteolytic enzyme. It should be noted that the final product of such an arrangement could be enhanced by the inherent slightly positive surface charge of the cationic liposomes mentioned above. To prevent enzymatic action by the proteolytic enzymes on the material of which the liposomes are comprised, and to maintain competitive pricing of the products formed thereby, the cationic liposomes, if utilized herein, are preferably prepared from behenylamidopropyl dimethylamine behenate.
A first embodiment of an enzyme separation system of the present invention provides a stable and efficacious formulation effective in the treatment of lice infestation in humans (i.e., pediculosides).
Conventional treatment of human lice infestation (pediculosis) requires a three-step process. The first step is to use a shampoo containing a pediculoside. For example, RID� is a pediculoside manufactured by Pfizer, Inc. RID� is applied to areas of the body containing hair in which lice tend to hide, e.g., the scalp. The shampoo treatment kills the adult lice. The shampoo treatment also kills some of the lice eggs (referred to interchangeably hereinafter as nits). However, some of the nits survive conventional methods of insecticide treatment, presenting a reinfestation possibility and hazard.
The second step in conventional human lice infestation treatment by pediculoside is to carefully comb each strand of human hair at the area of infestation with a fine-toothed comb to remove all of the nits, dead or alive. This is no easy task. Nits are composed of an outer shell comprising chitin (a complex polysaccharide) and a protein. The nits are affixed to the hair shafts with mucin (a complex glycoprotein). Accordingly, it is only by conscientious often painful combing that the nits are pulled free of the strands of hair to which they are attached.
This process is as effective as the "comber" is conscientious but it still does not guarantee complete removal of the nits. All nits, dead or alive, must be removed because even if 100% of the nits have been killed by application of the insecticide-containing shampoo, the presence of dead nits in one's scalp may have serious repercussions. For example, health care workers, e.g., teachers, nurses, etc., will consider the presence of the nits, live or dead, as indicia of infestation, which may very well result in a student, formerly infested, being removed from school with considerable social stigma attached.
A third step may be taken to render the complete nit removal more effective. This may be accomplished by applying several other human lice infestation products marketed as adjuncts to facilitate the second step in the process. That is, the third step is meant to ease the combing task and ensure complete removal of the nits from the hair. For example, CARE Technologies, Inc. markets a product Clear™, designed to aid in nit removal during the combing process called for by conventional pediculosis removal methods. According to the product's label, Clear™ contains: transferase, oxidoreductase, lyase, hydrolase, isomerase and ligase. The label clearly indicates that the product is intended for use in releasing nits from the hair strands to facilitate their removal by combing.
The enzyme separation system described herein realizes a capacity to combine enzymes which specifically destroy chitin and mucin. Hence, a composition of matter is disclosed which provides for the combination of glycolytic and proteolytic enzymes which, if properly delivered, will destroy both the carbohydrate and protein moieties of the mucin and the nit shell contents (the embryo). The chitin destruction by the glycolytic enzymes ensures that nits which have escaped death from the insecticide shampoo will be killed. The mucin destruction by the proteolytic enzymes ensures the release all of the nits from the hair shafts and/or clothing, dead or alive, thus permitting them to be washed away.
Preferably, papain is utilized as the proteolytic enzyme and chitinase or lysozyme as the glycolytic enzyme. The enzymes chitinase or lysozyme, or some combination of the two, will cleave chitin and other polysaccharides into disaccharides. The enzyme papain will cleave many proteins, including those of mucin, into smaller polypeptides.
Formulations and/or delivery systems for the delivery of a proteolytic and glycolytic enzyme, such as papain and lysozyme have proved elusive until the present invention. That is, formulations including papain typically include a papain inhibitor to prevent the degradation of chitinase by same. The resulting conventional products are only moderately effective in killing lice.
The present invention, by separating the two enzymes in formulation until their combined action is required, increases both the effectiveness and the shelf life of a pediculoside formed thereby. Further, by utilizing cationic liposomes to deliver the enzymes, upon an occurrence of a condition to precipitate liposomal delivery, good adhesion to hair follicles and or skin is realized.
Chitinase activity is determined by measuring the decrease in turbidity of a colloidal chitin suspension over time. Lysozyme activity is determined by measuring the decrease in turbidity of a suspension of Micrococcus Iysodeikticus over time. Papain activity is determined by measuring the hydrolysis of benzoyl-arginine ethyl ester. These assays have been used to assess the efficiency with which the enzymes are encapsulated within the cationic liposomes in the formulation and/or system of this invention, thereby determining the stability of the enzymes over time.
In order to test the efficacy of the present invention in protecting the susceptible enzyme from attack from the proteolytic enzyme, four preparations were prepared and observed over time. In the first preparation, a non-proteolytic enzyme and papain (i.e., the proteolytic enzyme) were both present in solution in the absence of any encapsulation system separating the non-proteolytic enzyme from the papain. In the second preparation, the microencapsulation system of this invention was used to encapsulate the non-proteolytic enzyme and therefore maintain it separately from the papain. The microencapsulation system utilized Catezomes™ to encapsulate the non-proteolytic enzymes. No attempt was made to remove the non-proteolytic enzymes from the external phase, i.e., unencapsulated. Papain was then added to the liposomal dispersion of the fourth preparation.
Both the first and second preparations were allowed to sit over time, observed and tested every several weeks to determine the activity levels of non-proteolytic enzyme. The results are shown by the dashed and solid lines of FIG. 1. As predicted and as evidenced by the dashed line of FIG. 1, the papain proteolysed the non-proteolytic enzyme such that the amount of same in solution decreased over time. Indeed there was no detectable non-proteolytic activity in the first preparation after three months.
In the second preparation, as in the simple enzyme mixture, the papain resulted in proteolysis of the non-proteolytic enzyme on the outside of the Catezomes™ and thus the non-proteolytic enzyme activity remaining in the solution decreased over time. However, the non-proteolytic enzyme of the second preparation that was present inside the Catezomes™ was protected from proteolytic attack. Thus, FIG. 1 shows that the non-proteolytic enzyme activity overall within the second preparation decreases only until all of the external non-proteolytic enzyme has been destroyed. The preparation as a whole retains non-proteolytic enzyme activity due to the fact that the encapsulated non-proteolytic enzyme is protected from the papain. Thus by preparing the system such that the required non-proteolytic enzyme is encapsulated, a stable preparation can be maintained over time.
Like the first and second preparations described above, third and fourth preparations were prepared with a specific non-proteolytic enzyme, lysozyme, and observed over time for enzyme activity. In the third preparation, lysozyme and papain (i.e., the proteolytic enzyme) were both present in solution in the absence of any encapsulation system separating the lysozyme from the papain. In the fourth preparation, the microencapsulation system of this invention was used to encapsulate the lysozyme and therefore maintain its separateness from the papain. The microencapsulation system utilized Catezomes™ to encapsulate the lysozyme. No attempt was made to remove the lysozyme from the external phase, i.e., the unencapsulated lysozyme in the fourth preparation. Papain was then added to the liposomal dispersion of the fourth preparation.
The resulting lysozyme activity of the third and fourth preparations is shown in FIG. 2 as a result of the measurement over time of the lysozyme activities of the third and fourth preparations. In the third preparation, as predicted, the papain resulted in proteolysis of the lysozyme and thus the lysozyme activity remaining in the solution decreased over time. Indeed there was no detectable non-proteolytic enzyme activity in this solution after three months as shown by the dashed line of FIG. 2. In the fourth preparation, Catezomes™ were found to protect the lysozyme over time. That is, while the papain resulted in proteolysis of the non-proteolytic enzyme on the outside of the Catezomes™, and thus the non-proteolytic enzyme activity remaining in the solution decreased over time, the lysozyme present inside the Catezomes™ was protected from proteolytic attack. Thus in FIG. 2, the solid line evidences that the lysozyme activity of the overall preparation decreases until all of the external lysozyme has been destroyed but the preparation as a whole retains lysozyme activity due to the encapsulated lysozyme. Thus by preparing the system such that the required lysozyme activity is encapsulated, a stable preparation is made.
Of course similar results are found when the proteolytic enzyme is encapsulated within the liposomal vesicles as taught herein, and the non-proteolytic enzymes remain outside of the vesicles. As long as the efficacy of the liposomal vesicles is maintained, the non-proteolytic enzymes are prevented from proteolysis by the encapsulated protease. For that matter, the foregoing description is meant for illustrative purposes only and those skilled in the art may find other materials and methods which accomplish the same results. Such other materials and/or methods are reflected in the scope of the following claims.
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|Wahl Arnold S
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|Hayward; James A.
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|Citing Patent
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|May 3, 2000
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|Jan 8, 1998
|Dec 16, 2003
|Stephen L. Tvedten
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|Removal of dye-labeled dideoxy terminators from DNA sequencing reactions
|Oct 16, 2003
|Jul 1, 2008
|Tvedten Stephen L
|Biological pesticide
|Oct 6, 2004
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|Enzyme-based device for environmental monitoring
|Oct 16, 2003
|May 13, 2004
|Tvedten Stephen L.
|Biological pesticide
|Oct 6, 2004
|Apr 6, 2006
|Lejeune Keith E
|Enzyme-based device for environmental monitoring
|Oct 31, 2007
|May 8, 2008
|Tvedten Stephen L
|Biological pesticide
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|U.S. Classification
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|International Classification
|Cooperative Classification
|European Classification
|Jan 10, 1997
Owner name: COLLABORATIVE LABORATORIES, INC., NEW YORK
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Year of fee payment: 12


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The overall scope of the UNDG Sustainable Development Working Group (SDWG) would be the acceleration of the progress towards achieving the MDGs and the implementation of the post-2015 development agenda with its main objective being to formulate policies and strategies which help support the implementation, monitoring, and reporting of the Post-2015 agenda to be agreed by the UNGA. Key on this regard will be to ground its work in cutting-edge analytics and strategies focused on the "dark spot" of inequalities (on gender and others), injustices, lack of rights and heightened vulnerability and risk.
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2925 G Avenue E,Kalamazoo MI, 49004
Sold Price
3 beds , 1 Full/1 Half baths
1,192 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Michigan Real Estate
(877) 808-7007
Last Updated: 2/25/2017 4:05 PM
Description for 2925 G Avenue E Kalamazoo, MI 49004
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Listing Information
Cooper Twp
Softener Own, Public Water Service
Public Sewer
Cable TV, Electric, Natural Gas, Telephone
School Information
Room Information
Eat-In Kitchen
Interior Features
Dishwasher, Dryer, Range, Refrigerator, Washer
Ceramic, Wood
Central Air, Ceiling Fan(s)
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Inside AccessTM
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Active Market Trends
Source:MLS DATA
Median list price$135,200
Days on market90
Properties for sale382
Sold Market Trends
Source:MLS DATA
Median sold price$131,700
Sales to list price9,793.0%
Properties sold474
Median sq ft price$80
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Listing Price History for 2925 G Avenue E
Kalamazoo Real Estate
Kalamazoo is located in Michigan. Kalamazoo, Michigan 49004 has a population of 74,494.
The median household income in Kalamazoo, Michigan 49004 is $31,189. The median household income for the surrounding county is $46,011 compared to the national median of $53,046. The median age of people living in Kalamazoo 49004 is 25.9 years.
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- 05-24-2013, 06:04 PM Thread Author #1
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Debug but for Android?
I love the debug podcast on iMore and it really helps me get inspired to be an iOS developer and showcases some really great developers that work as part of small teams. But I really want too see this from android side as its the platform I use more and want to develop more for.
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hello there! Im new to the forum but a android fan for a long time!!By bigstomachking in forum IntroductionsReplies: 4Last Post: 09-25-2012, 08:02 AM
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