text:
Even as the Trump administration closes US borders to some refugees, Canada's decades-old private refugee sponsorship program is getting another look by nations struggling with their own influxes of migrants.
Russia, Iran, and Turkey agreed Tuesday to sketch the outlines of a wider political settlement to Syria's civil war, which would be taken to larger talks in Geneva that include the US, the EU, and other major players.
Their partnership on Syria marks a significant shift for Turkey's President Erdoğan. Still, analysts say, there are limits to Russia's new friendship with Turkey.
Erdoğan pledged that he would keep Turks safe in a tumultuous region. Amid public anger, his dream of creating an all-powerful presidential system may now hang in the balance.
Rebel groups have signed on to the deal, but commanders tell the Monitor that if their political goals are not met they'll return to war.
The conflict with ISIS and even older war in Syria will continue to radiate ferment across a region that will also witness an as-yet unknown Trump effect.
After several years of economic hardship and international pressure over its annexation of Crimea, Russia may see its lot improve next year. But most are skeptical of the possibility of lasting change.
Donald Trump's ascendance in Washington and Russian President Vladimir Putin's increasing influence promise to make next year a tumultuous one.
The war in Syria is far from over, and the anti-Assad rebels have vowed to fight on. Many are congregated in Idlib province. But before the Syrian president elects to go after them, he has other options to consider.
Assad's key allies say the victory over rebels in Syria's second city advances their standing globally and in the region. But with no quick end to the conflict, they are likely to push for a political solution, analysts say.
Russian experts know ExxonMobil CEO and Secretary of State nominee Rex Tillerson well, and see Trump's selection of him as a signal that genuine detente is a possibility.
When Iraqi forces moved on Mosul, IS moved enslaved Yazidis back to Syria, frustrating activists trying to free them. But their relocation might make it easier to find and rescue them.
By letting refugees from Syria, Afghanistan, and elsewhere into its work training programs, Germany can help its shorthanded enterprises – and enable the new workers to get on with their lives in a sustainable way.
There is little optimism in Russia that there could be a serious reconciliation between Washington and Moscow, even if Donald Trump is in the White House. But if it happened, this is what Russian analysts say it would have to entail.
Despite the president-elect's campaign-trail promise to 'knock out ISIS,' experts say that Trump's options in Syria are already limited.
The Turkey-Kurdish peace process that Erdoğan once championed hits a new low, felled by Syria's conflict and his own ambition.
While Russian and Syrian forces are set for a major offensive on Aleppo after the end of today's cease-fire, the potential military success is overshadowed by the Kremlin's inability to return to superpower-style dealing with the US.
In Italy's south, villages are aging quickly as youth move away for better jobs. But some are finding new life by hosting refugees from the Middle East and Africa.
Though Russia's economy has suffered in recent years, due in part to Western sanctions over Russian activities in Ukraine, the Kremlin – and the Russian public – have shown little sign of yielding.
Migrants, as they wait for their asylum applications to be processed, are increasingly ending up on the streets of the French capital, adding to the tens of thousands already there.
The war of words over Syria – including accusations of Russian war crimes in Aleppo – has relations between Moscow and Brussels at their worst in years. But both sides recognize that nothing can be done without the other.
Syria's second city of Aleppo is under siege, with Russian and Syrian airpower pounding myriad targets, including hospitals. Dr. Zaher Sahloul of ARCS, last in Aleppo in July, shared his experience with the Monitor.
The White Helmets, a Syrian civil defense group, have faced daunting challenges from intense airstrikes and artillery shelling over the past two weeks.
In their overwhelming attacks on eastern Aleppo, which spurred the US to suspend talks with Moscow, Russia and Syria are seeking a favorable political outcome through time-tested – if brutal – military means.
Hungarians who voted Sunday overwhelmingly favored Prime Minister Viktor Orbán's policy to reject the EU plan to distribute refugees fairly across the bloc. Not enough voted to validate the result, but that may not indicate a public change of heart on immigration.
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Published on 6th September 2013 by David Hing
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Important Update: Calorie Count will be shutting down on March 15th. Please click here to read the announcement. Data export is available.
Wolff's Nutrition
The Birkett Mills is the World?s largest manufacturer of Buckwheat products. Established ? and in continual operation ? since 1797, we have over 200 years of buckwheat, soft white wheat, and custom grain milling experience in the U.S. market, as well as many worldwide customers.
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Five Days in Paris
By (author) Danielle Steel
Format: Paperback
Normal Price: $16.34
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Five Days in Paris by Danielle Steel
Book DescriptionPeter Haskell, president of a major pharmaceutical company, has everything: power, position, and a family which mean everything to him. Olivia Thatcher is the wife of a famous senator. She has given to her husband's ambitions and career until her soul is bone-dry. She is trapped in a web of duty and obligation, married to a man she once loved and no longer even knows; when her son died, a piece of Olivia died too. On the night of a bomb threat, Olivia and Peter meet accidentally in Paris. Their lives converge for one magical moment in the Place Vendome, and in a cafe in Montmartre their hearts are laid bare. Peter, once so sure of his marriage and success, is faced with his professional career in jeopardy - Olivia, no longer sure of anything, knows that she cannot go on any more. When Olivia disappears, only Peter suspects that it may not be foul play, and he has to find her again. But where will they go from there? Five days in Paris is all they have. Home again, they must both pursue their lives, despite challenges, compromise and betrayal. Everything they believe is put on the line, until they both realise that they must face life's challenges head-on.
Buy Five Days in Paris book by Danielle Steel from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780552143783
(178mm x 106mm x 22mm)
Pages: 352
Imprint: Corgi Books
Publisher: Transworld Publishers Ltd
Publish Date: 7-Nov-1996
Country of Publication: United Kingdom
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Rushing Waters, Paperback (June 2017)
As Hurricane Ophelia bears down on New York City, millions are caught up in the horrific flooding it unleashes. Ellen Wharton flies into New York from London, heedless of the hurricane warnings. She is intent on seeing her mother, Grace. But when the storm hits, the women are forced to wade through freezing waters to the police boats outside.
Magic, Paperback (April 2017)View all books by Danielle Steel
It starts on a summer evening, with the kind of magic found only in Paris. Once a year in the City of Light, a lavish dinner takes place outside a spectacular landmark. Amid this wondrous White Dinner, a group of close friends stand at the cusp of change. A once-in-a-lifetime opportunity in China may lead to separation - and temptation.
US Kirkus Review » Steel (Lightning, p. 422, etc.), the Queen of Conjunctions (both human and grammatical) returns, this time with a page-turning, incantatory love story that's hard to beat and harder to put down. Two well-heeled lovers meet at the Ritz in Paris, "and a lifetime forever change[s] in a single moment." Successful and immaculately shirted Peter Haskell, pharmaceutical bigwig, has come to France to expedite the manufacturing of Vicotec, a drug that - if the lab tests are positive - will revolutionize cancer care. Peter, 44, and so well turned out that no one knows he was once a poor Wisconsin farmboy, married Katie, the boss's daughter, and compromised his ideals all the way to the tune of three sons and a large, splendid house on six acres in Greenwich, Connecticut. Now, forced to wait five days for Vicotec's test results, he spies Olivia Thatcher, 34, the big-eyed, waiflike, neglected wife of Senator Anderson Thatcher, and becomes instantly fascinated. The night of a bomb threat, Peter follows tragic Olivia (she's lost a son to cancer) down the Champs-Elysees. Later, after six hours at a Montmartre cafe, the two have bonded for life. When Olivia is too miserable to return to her empty life at the Ritz, Peter follows her again - this time to a quaint fishing village in the south of France, where, after salade nicoise, they become lovers. But each has obstacles keeping them apart. Peter returns to New York to battle with his family over Vicotec, as well as face the FDA; Olivia promises Andy, a presidential wannabe, that she'll stick it out through the election. But will the lovers be able to carry on as usual behind their old facades? In the end, with nothing but each other, and a few other little goodies, they face the future together. A bread-and-butter chanson d'amour that no one could write better - and many have tried. (Kirkus Reviews)
» Have you read this book? We'd like to know what you think about it - write a review about Five Days in Paris book by Danielle Steel and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Danielle Steel
Danielle Steel is one of the world's most popular and highly acclaimed authors, with over ninety international bestselling novels in print and more than 600 million copies of her novels sold. She is also the author of His Bright Light, the story of her son Nick Traina's life and death; A Gift of Hope, a memoir of her work with the homeless; and Pure Joy, about the dogs she and her family have loved. To discover more about Danielle Steel and her books visit her website at www.daniellesteel.com You can also connect with Danielle on Facebook at www.facebook.com/DanielleSteelOfficial or on Twitter: @daniellesteel
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A bachelor's degree is a hallmark of higher education. It is given to those who dedicate three to seven years studying a specific program. A bachelor's degree can be earned in a variety of disciplines in the arts and sciences.
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Former Clay County Bar President. Practicing law since 1967. Everyone has a right to vigorous and aggressive legal representation. The David Lee Wells Law Office strives to provide understanding to individuals in stressful times of their lives whe...
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Irwin Naturals, Dr. Linus Pauling, Super Multi Vitamin, with Herbs & Energizers, 120 Caplets
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Expiration Date:?Aug 2018Expiration Date
The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.
Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.
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Shipping Weight:?0.41 lbsSwitch to Metric units
- Product Code: IRW-25315
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2.5 x 2.5 x 4.5 in, 0.35 lbsSwitch to Metric units
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Along with friend Albert Einstein, Linus Pauling is considered by many to be a leading scientific figure of the 20th century. Here are only a few of his accomplishments:
- The only person to have received two unshared Nobel prizes (1954 and 1962)
- One of the founders of both modern chemistry and molecular biology
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In 1993 Dr. Pauling lent his name to support a ground breaking new line of vitamin products. Dr. Linus Pauling Premium Vitamins are formulated according to Dr. Pauling's scientific principles of nutrition.
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(Adult) Take 2-3 caplets with a full glass of water (preferably with a meal).
Other Ingredients
Cellulose, maltodextrin, stearic acid, silicon dioxide, croscarmellose sodium and magnesium stearate.
Do not use if safety seal is broken. Check with your doctor before using this product if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing. Do not exceed recommended daily intake. Not intended for use by persons under 18. Keep out of reach of children. Store in a cool, dry place.
(State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.
|Supplement Facts
|Serving Size: 3 Caplets
|Servings Per Container: 40
|Amount per Serving
|%Daily Value
|Vitamin A (as Vitamin A Acetate, 20% as Beta Carotene)
|Vitamin C (as Calcium Ascorbate)
|60 mg
|Vitamin D (as Ergocalciferol)
|Vitamin E (as d-Alpha Tocopheryl Acetate)
|Vitamin K (as Phytonadione)
|20 mcg
|Thiamin (as Thiamin Mononitrate)
|20 mg
|20 mg
|Niacin (as Niacinamide)
|20 mg
|Vitamin B6 (as Pyridoxine Hydrochloride)
|12 mg
|Folic Acid
|390 mcg
|Vitamin B12 (as Cyanocobalamin)
|100 mcg
|60 mcg
|Pantothenic Acid (as d-Calcium Pantothenate)
|10 mg
|Calcium (as Dicalcium Phosphate)
|120 mg
|Iron (as Ferrous Fumarate)
|8 mg
|Phosphorus (as Dicalcium Phosphate)
|116 mg
|Iodine (as Potassium Iodide)
|150 mcg
|Magnesium (as Magnesium Oxide)
|50 mg
|Zinc (as Zinc Oxide)
|15 mg
|Selenium (as Selenium Aspartate)
|40 mcg
|Copper (as Copper Oxide)
|4 mg
|Manganese (as Manganese Sulfate)
|3 mg
|Chromium (as Chromium Polynicotinate)
|14 mcg
|Molybdenum (as Sodium Molybdate)
|50 mcg
|Alfalfa powder (leaf)
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|25 mg
|Spirulina (Arthrospira platensis) powder
|25 mg
|Echinacea purpurea powder (root)
|20 mg
|Vanadium (as Sodium Metavanadate)
|20 mcg
|Nickel (as Nickelous Sulfate)
|2.5 mcg
|Phyto-Herbal Complex
Ginkgo powder (leaf), Garlic powder (bulb), Grape Seed extract, Apple powder (fruit), Broccoli powder (aerial), Carrot powder (root), Orange powder (fruit)
|38 mg
|†Daily Value not established
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The global pet care market is foretold to improve in the forthcoming years as matched to the preceding years and will showcase better sales in various market segments. It is estimated that the global pet care market will grow at a CAGR o…
Sales, means the sales volume of Ethyl Methanesulfonate
Revenue, means the sales value of Ethyl Methanesulfonate
This report studies sales (consumption) of Ethyl Methanesulfonate in Global market, especially in USA, China, Europe, Japan, India and Southeast Asia, focuses on top players in these regions/countries, with sales, price, revenue and market share for each player in these regions, covering
- Alpa Aesar
- Shanghai ACT chemical Limited
- Hangzhou J&H Chemical Co., Ltd.
- China Skyrun Industrial CO.,LTD
- SIGMA-ALDRICH Corporation
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- Gihi Chemicals Co., Limited
- Kinbester Co., Ltd.
- TCI America
- Chemical Reagent
- Triveni Interchem Pvt Ltd
- Shanghai Qianchen Biotechnology Company
- Shanghai Haoran Biological Technology CO.,LTD.
- Leap Labchem Co., Ltd
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- Santa Cruz Biotechnology, Inc.
- Beijing Zhongshuo Pharmaceutical Technology Develo
Market Segment by Regions, this report splits Global into several key Regions, with sales (consumption), revenue, market share and growth rate of Ethyl Methanesulfonate in these regions, from 2011 to 2021 (forecast), like
- China
- Europe
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Split by product Types, with sales, revenue, price and gross margin, market share and growth rate of each type, can be divided into
- Type I
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Split by applications, this report focuses on sales, market share and growth rate of Ethyl Methanesulfonate in each application, can be divided into
- Application 1
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text:
Bispecific Antibodies Close in on Cancer
Plotting Molecular Pincer Movements, Denying Cancer Room to Maneuver
Troubleshooting SPR
Resolving Nonspecific Binding, Regeneration and Other Problems
Data Deluge
Researchers Turn to Cloud Computing as Genomic Sequencing Data Threatens to Overwhelm Traditional IT Systems
Seeking Young Scientists for Research in Space
Sounds of Science Podcasts
ICON Acquires Aptiv Solutions for $143.5M
ICON said today it will acquire Aptiv Solutions for $143.5 million, in a deal that adds the acquired CRO's expertise in adaptive clinical trials to the buyer's array of outsourced development services for biopharma and medical device companies.
ICON will acquire Aptiv Solutions from its owners, The Halifax Group, SV Life Sciences, Comvest Partners and Management, in a transaction subject to unspecified closing conditions. In addition to designing and carrying out adaptive clinical trials for biopharma and medical device sponsors, Aptiv Solutions sells statistical software intended for use in those trials.
Aptiv Solutions expanded its adaptive clinical-trial services into cancer therapeutics and other trials with long-duration endpoints on March 18, when it released the latest version of its ADDPLAN® statistical software. The company says ADDPLAN 6.1 is the first statistical software enabling the use of surrogate endpoints to speed up interim analysis decisions in adaptive clinical trials. ADDPLAN counts among its customers more than 50 pharma and medical device makers, as well as key regulatory agencies that include the FDA, the European Medicines Agency, and Japan's Pharmaceuticals Medical Devices Agency.
Japan is where ICON will combine its operations in Tokyo and Osaka with one of Aptiv Solutions' companies—Niphix, a full-service, oncology-focused CRO serving both Japanese and international customers.
"Aptiv Solutions' adaptive trial capabilities will further differentiate and enhance our services to help our customers identify the most promising drug candidates earlier. Their presence in Japan will also broaden our existing capabilities in this market," Nuala Murphy, Ph.D., president of ICON Clinical Research Services, said in a statement.
ICON's programs to support clinical development range from compound selection to Phase I-IV clinical studies. Dublin-based ICON has about 10,300 employees operating from 77 locations in 38 countries.
Headquartered in Reston, VA, Aptiv Solutions has more than 850 professionals in 16 countries stretching across North America, Eastern and Western Europe, Israel, and Japan.
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Illinois river float trip
Explore related topics
Float trip down Illinois River in Tahlequah, Oklahoma I'm ready!!! My friends and I LIVED for the summer and these waters!
Oklahoma Illinois River Tahlequah Ok Float Trips Canoe, Rafts, Camping
Illinois River Float Trips and Camping: The Illinois River in Tahlequah offers a gentle, moderate current and plenty of canoe, kayak and raft outfitters along its scenic banks, making it a favorite float trip destination
Tahlequah, OK - The Illinois River. I grew up visiting this river at least 3 times a summer. My husband and I now take our children every chance we get. It is beautiful in Tahlequah, the water is clear and cool and the float trips are some of the most fun you can have in Oklahoma.
Illinois River Float Trips
Illinois River Float Trips and Camping | TravelOK.com - Oklahoma's Official Travel & Tourism Site
Illinois River Float Trips and Camping | TravelOK.com - Oklahoma's Official Travel & Tourism Site
Illinois River - float trip one more time
Float Trip Reports - Illinois River Tahlequah, OK
Tahlequah is located at the foothills of the Ozark Mountains in Green Country and boasts spectacular scenery. You won't be able to drive through town without stopping to check it out.


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State finals slip away from Summit High School's Hailey Wyatt
February 10, 2013
Summit High's Hailey Wyatt took 17th of 22 divers at Saturday's state swim and dive meet in Thornton.
Wyatt was the only Summit High representative at the competition, after qualifying for state at the Western Slope Conference Championships by .30 points.
"She didn't do as well as she wanted to, but I don't think she expected the level of competition that was there," dive coach Joe Baldwin said, explaining that she was among the top divers in the 4A division across the state.
He said she wanted to make finals. She missed making the cut of 16 divers by .25 points.
Wyatt thrived off the pressure, though, the coach said.
"She knew what she had to do, and she executed really well," Baldwin said, adding that because of Wyatt's dive rotation, she wasn't able to do her top three dives – the back somersault one-and-a-half twist, the inward one-and-a-half pike and the front double pike, which is arguably her best.
"It was really great for her to see the type of competition that's out there," Baldwin said. "They were doing some good dives, and doing them well."
Meet results weren't available as of press time.
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13 Triangle Park Dr., Concord, NH 03301Request info Add to list
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Donna R.
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Building Details:
13 Triangle Park Dr. is aland property for lease in Concord, NH. The property currently has 1 land for lease and is marketed by Premiere Properties.
Triangle Park Dr. intersects with Rt. 106 behind Target. Lot is 800' East of Rt. 106.
Flat, wooded lot, sandy soils. Neighbors are: Laconia Savings, D'Amante Law Firm, Goodale Bikes, Municipal Assoc.
Zoned office/retail. Survey available.
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White House Black Market Coral Pointy Toe Low Heel
$37 Sold out whitehouseblackmarket.com
Coral Pointy Toe Low Heel by White House Black Market. V-shaped vamp low heel in a coral tone for girlish charm. Golden touches and a pointed toe bring work-ready sophistication. Our obsessively great fit feels as beautiful as it looks. Breathable lining. Adjustable ankle strap. Super-comfortable memory foam footbed. Leather sole scored for traction. Leather and manmade materials. Imported. 2.75" heel. WHBM
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820ft - Heat Included, Dining Room, Large Closets S. Clinton and Elmwood Prices starting at: $910 per month; Total Sq. Ft. : 820; Prices starting at: $935 per month; Total Sq. Ft. : 910; Imperial South Apartments is located in Brighton, New York, one of Rochester's most delightful and desirable → Read More
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Fremantle Dockers
Mayne says he's got years to offer Magpies
At 28 and after nine years at Fremantle, Collingwood recruit believes he has up to six years of AFL football in him.
New Cockburn home for Fremantle Dockers bolsters spirits for 2017
Fremantle defender Lee Spurr hopes the club's recent move to their new home in Cockburn will help them banish the demons of 2016 and reach the finals this season.
$1.2 million price tag on Fyfe
Victorian clubs inquiring about the services of new Fremantle captain Nat Fyfe have been told they would have to pay more than $1.2 million per season to lure him away from Western Australia.
Clash of the titans in first Eagles, Dockers derby showdown
West Coast looks set to unveil boom recruit Sam Mitchell in a unique western derby showdown with arch enemy Fremantle on Saturday at Western Australia's mid-western coastal town Geraldton.
GWS, Freo fight out historic AFLW draw
By Adrian Warren
AFLW live: GWS v Fremantle
Follow the scores and statistics as the Giants host the Dockers in game one of the third round.
Five things Dockers and Eagles fans need to watch for in pre-season
The AFL's pre-season is a mix of phoney war and true blood where teams test their players and tactics to see what hits and what misses.
Leading lights: season of change at top for AFL clubs
There has been a rash of changes to the captaincy arrangements at AFL clubs.
Lyon gives Dockers fans a look at club's likely round one line-up
A preseason intra-club game could provide an major insight into Dockers coach Ross Lyon's starting line-up for round one of the AFL season.
Did the Dockers make the right choice appointing Fyfe captain?
WAtoday football writers Brendan Foster and Justin Rake give 'Fyfe reasons' why the Dockers new captain choice was the right call or not.
Nat Fyfe to captain Fremantle Dockers in 2017 AFL season
Brownlow medallist Nat Fyfe has been named captain for the Fremantle Dockers for the AFL season 2017 on Tuesday.
Nat Fyfe named Fremantle skipper
A year after being overlooked to replace veteran Matthew Pavlich as Fremantle's newest skipper, Brownlow medallist Nat Fyfe has been voted into the role for 2017.
Knee injury ends Mickle's season
Luckless Fremantle player Kim Mickle will miss the rest of the AFL Women's season after scans confirmed she ruptured an anterior cruciate ligament during her Dockers debut.
Dockers boss positive he can keep high-priced Fyfe
But the Dockers boss concedes that winning a signature from one of the game's biggest stars could be delayed until well into the 2017 premiership home-and-away series.
Live AFLW: Fremantle v Brisbane
The Dockers host the Lions to close out round two of the AFLW season.
Lessons from a lost year: Ross Lyon opens up
Ross Lyon realised watching Fremantle last year during the pre-season competition that something was not right with his team.
Speculation on Bennell injury has racist overtones: Lyon
Media speculation surrounding Harley Bennell's debilitating calf injury has racist overtones according to his coach Ross Lyon.
'Nothing is forever': Is Ross Lyon preparing for life after Nat Fyfe?
Dockers coach Ross Lyon may have dropped the biggest hint yet that the club is preparing for life after Nat Fyfe.
It's laughable to suggest the Dockers and Eagles won't play at Perth Stadium
"The siren is about to go. "The Eagles need a goal to win.


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You missed it This great deal for Ring O' Bells is over. But don't despair, we've got more great deals every day.
Can't remember the last time you enjoyed delicious, continental cuisine in a traditional, family-owned pub? Then today's deal from Ring O' Bells is sure to, ahem, ring a bell.
Want more? Check out Ring O' Bells on Facebook.
Enjoy By 12 March, 2014
*'lower price' discount may not apply to multiple purchases, select your options to see your final price. By purchasing, you agree to the deal fine print and the LivingSocial terms and conditions.
By clicking 'Buy Now!', I agree to the Terms and Conditions and the Privacy Policy.


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Lock-back Folding Knife
This stylish and rugged folder knife is equipped with the patented Klecker Lock Mechanism – a lock-back in which the spring, lock-bar and detent are all integral to the frame structure. The handle features a handsome combination of gun-metal gray stainless steel and layered brown and black G-10 inserts complimented with polished brass accents. The reversible pocket clip is designed for tip up or tip down carry in a pocket, on a belt or in a bag.
|Extended Length
|8.56" 217mm)
|Closed Length
|5.8 oz (164g)
|2Cr13 SS
|Edge Included Angle
|30-40 degrees
|Drop Point
|Rockwell Hardness
|3.63" (92mm)
|.111" (2.8mm
All Klecker Knives products are covered by a Lifetime Warranty. If you have any questions about the warranty or about your Klecker Knife product, please contact: email@example.com
Showing reviews 1-3 of 4 | Next
Posted by Carlos Gomez on 7th Apr 2016
This knife is made with a very high grade quality and I'm very satisfied with the purchase I made. I'll recommend purchasing a knife with this kind of quality it was made. Easy to open with 1 hand and stays razor sharp.
Posted by ru124t on 27th Sep 2015
This is now the crown jewel in my knife collection. From its beautiful color to the dual finish blade, everything in this knife screams quality! I would consider this an EDC or a gentleman's folder. Don't let this dissuade you. This knife can take everything you throw at it and comes back better every time ! If there is one thing I would change on this knife, I would use a slightly better quality blade steel. This is not a knock against the steel used, it is just that with a knife so beautiful, screams to have a better blade steel, though the stuff used is still not bad.
As I said, this is now my favorite knife and I am proud to own it. Buy this knife, you will not be disappointed!!!
Posted by Will Secrest on 17th Jan 2015
I had purchased one for my son from Think Geek and then later I decided the quality was great and decided to purchase my own. However, Think Geek was out so I came for the original :)
Showing reviews 1-3 of 4 | Next
All prices are in USD


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Today's Featured Artist: Michael Godard
Need your order in time for Christmas? Check out our Holiday Shipping Deadlines.
Transform your photos into one-of-a-kind, hand painted masterpieces!
Protect your iPhone 7 with a brand new iPhone 7 phone case!
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Fine Art America has expanded to 14 fulfillment centers in 5 countries!
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Our greeting cards are 5" x 7" in size and are produced on digital offset printers using 100 lb. paper stock. Each card is coated with a UV protectant on the outside surface which produces a semi-gloss finish. The inside of each card has a matte white finish and can be customized with your own message up to 500 characters in length. Each card comes with a white envelope for mailing or gift giving.
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1 - 2 business days
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Charlotte, NC
Front View
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Inside Message
Inside View
Exquisite still life, Timothy! The game of shadows and lights is fantastic...:) f&V!
I love the light, shadow and beautiful color! Nice work Tim!!!
Wonderful work, Timothy! Love the lighting!
These are fresh peaches from Vanzant Farms, a local orchard. Executed in a loose, yet realistic style, this image depicts a paper sack of peaches spilled out onto our porch into the dappled sunlight. I enjoyed the way the sunlight illuminates the paper sack. The peaches were DELICIOUS. The kind where the juice runs down to your elbow.
Timothy Jones spent his first 14 years in Alaska, where he developed a deep appreciation for the beauty of the Alaskan landscape and a love for making art. The family moved to Arkansas, where he earned bachelor's and master's degrees in fine art. Since 2004, after a number of years as a designer and illustrator, Tim has been building a portfolio primarily of classical realist still life painting. He is fortunate to have lived near and studied with a few well-known realist painters.His art has received local, regional and national recognition in shows and competitions such as those of the Art Renewal Center and Oil Painters of America. He now lives with his family in Minneapolis, Minnesota, where he paints and teaches a classical art...
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee. We take great pride in the fact that hundreds of thousands of artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
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All greeting cards ship from our production facility within 1 - 2 business days of your order.


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Cowboys & Aliens - Triple Play (Blu-ray + DVD +
Guide price: £14
Last updated on 7th Jan 2012
Cowboys & Aliens - Triple Play (Blu-ray + DVD +
The Old West... where a lone cowboy leads an uprising against a terror from beyond our world. 1873. Arizona Territory. A stranger with no memory of his past stumbles into the hard desert town of Absolution. The only hint to his history is a mysterious shackle that encircles one wrist. What he discovers is that the people of Absolution don't welcome strangers, and nobody makes a move on its streets unless ordered to do so by the iron-fisted Colonel Dolarhyde (Ford).
It's a town that lives in fear. But Absolution is about to experience fear it can scarcely comprehend as the desolate city is attacked by marauders from the sky. Screaming down with breathtaking velocity and blinding lights to abduct the helpless one by one, these monsters challenge everything the residents have ever known.
Now, the stranger they rejected is their only hope for salvation. As this gunslinger slowly starts to remember who he is and where he's been. Actors Olivia Wilde, Daniel Craig, Harrison Ford, Sam Rockwell, Paul Dano, Noah Ringer, Clancy Brown, Ana de la Reguera, Keith Carradine, David O'Hara, Walton Goggins, Abigail Spencer, Adam Beach, Toby Huss & Chris Browning Director Jon Favreau Year 2011 Screen Widescreen Languages English
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About this paper
Before starting any data quality or data governance initiative, an important first step is to set expectations. Specifying expectations provides a means for measuring and monitoring the conformance of data (and the associated processes) within an operational data governance framework. These expectations can be formalized under a data quality service level agreement (DQ SLA), which specifies the roles and responsibilities associated with managing data quality expectations and assuring that they will be met. This paper describes the techniques that can help support operational data governance through creation of DQ SLAs.
About SAS
SAS helps 80,000 organisations around the world take their data… And do amazing things… We help organisations turn large amounts of data into knowledge they can use, and we do it better than anyone. It's no wonder an overwhelming majority of customers continue to use SAS year after year. Find out more, Why SAS?
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text: Item is not available Find Another One Others Looked At... Sako TRG 42 .338 Lapua Desert Tan 20" 5r... SELLER: Ammo And Arms 1 $6,199.99 Sako TRG 22 .308 Winchester 20" 10Rds Bl... SELLER: Ammo And Arms 1 $3,199.99 ~!* BEAUTIFUL CLASSIC *!~ SAKO FORRESTER... SELLER: SBD Enterprises 1 $1,095.00 Sako Ultra Wildcat L461 (.223 Caliber) SELLER: Hunters Trading Post 1 $1,100.00 Sako Forester 243 DELUXE Pre-Garcia Bofe... SELLER: Shooting Investments 1 $1,199.00 Sako Forester L579 Finn Bear Deluxe, 308... SELLER: Southwest Shooter Supply 1 $1,400.00 Guns Rifles Sako Rifles Other Bolt Action L . Rem Pre Vixen Heavy Bbl | 1397 | 7 | Lc | 250.0179ms L-46 .222 Rem, Pre-Vixen Heavy Bbl For Sale from Perkiomen Gunworks | Positive feedback: 99% View | Verified Seller | 3185 Completed Sales View Sellers Items This item is no longer available. Description Shipping and Payment More Info Sako Riihimaki L-46 .222 Rem Heavy Bbl Varmint, BOFORS STEEL marked, 23.5 inch Heavy Bbl w/o sights, clip feed Pre-Vixen – 52xxx - in about 90-95% condition, raised cheek piece, checkered stock, white line spacers, leather sling, super all original Sako dating back to the early to mid 60's. Rate metal at about 96% with no marks or wear worth mention – bore is perfect. Rate wood at about 90% - no major marks but gloss finish is a little faded at cheek piece in spots – easily corrected if it concerns you – see photos. Sweetheart of an early Sako 222!!! +S&H to your local FFL dealer for transfer. To pay on line - go to - find item - put in your cart and check-out. All transactions will be charged a +2% maintenance fee. We will receive notice of your payment automatically. Then all we will need is for you to have your local transfer dealer fax, email or mail their FFL license copy to ship firearm. OR: To pay via mail with NO extra fees – email us and follow these directions: To commit to gun we need your full name, address and phone #. This will only be used to hold gun until your paperwork arrives. Will confirm back sale if you are the FIRST we hear from with this information. To commit to gun we need your full name, address and phone #. Will confirm back sale if you are the FIRST we hear from with this information. Most guns shipped lower 48 at $30.00 flat rate. Additional charges for special guns or heavier items will be stated in description or other text. Over night and hardcase shipping quoted. S&H is non-refundable for returns. Our listed price is for Check or Money order, all on line payments are subject to a +2% maintenance fee. Our web site: www.perkiomengunw Trades Accepted: Trade plus cash deals are considered - email us with details - photos would be a plus.We never do "Even" trades. All on line payments are subject to a +2% maintenance fee. Browning and Kimber Direct Dealer with access to ten major distributors for most firearms. Visit our web site: www.perkiomengunworks.com Located in central Tennessee – we are open BY APPOINTMENT ONLY. Our GunsAmerica sales count is well over 2640 guns with many repeat customers - we would be happy to have you as a customer too!! Email is the best way to contact us right off one of our ads. We must be first come first served to be fair.Email committing to buy with your full name, address and phone # will hold the gun for you if you are the first to commit. A confirmation reply will be back to you ASAP with instructions and our full address. Our phone # is listed for those wishing to call. Condition: Used, Minor Wear Caliber: .222 (all) Location: TN Share Item Item #: 992794104 Stock No.: 09235 This item is no longer available. Price: (Price reflects 3% cash discount.) This Seller Accepts Online Payment Shipping: $30.00 (or Arrange local transfer) Accepted Payment Methods: Returns: 3 Days Perkiomen Gunworks Seller Since: Feb. 2000 Seller Level: Trusted Seller This seller is an FFL City: Sparta State: TN Your Recently Viewed Items


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9 Ways You Drive Readers Away (And 9 Tips to Keep Them Reading)Webinar
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Preparing your newsroom to best serve the growing mobile audience.
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Work and play belong together, especially when building a new team or new products.
Defense Against the Digital Dark Arts: Online Protection for Women JournalistsWebinarSign up now for the
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Sharing is helping.
We offer you this space to share your knowledge about Magento and learn from our experienced customers.
I mean : ALL page, buttons : "account" and "log in"
when mouse hover on those buttons , you could see another highlight color
I would like only "account" button to be ALREADY highlighted, even if mouse not over
thanks a lot


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I haven't spent that much on repairing my favorite pair of $25 Uniqlo jeans, but at least twice over. Three of my jeans that I rotate are in need of repair again
I'm guessing you get them patched with old pieces of denim at the tailor like I do?
Anyone have experience having their jeans darned by guys like Self Edge? I always thought that $40 to get jeans repaired was too much, but it's worth it if it really lasts.
Another topic...
IMO, Raf has fallen off so much since his heyday. His last great collection for his namesake brand was FW 06. After that, he began to focus on his futuristic vision, which is not aesthetically pleasing to me.
There's no doubt that his current aesthetic has influenced a new generation of designers, like Siki Im and Peir Wu, but I guess his current direction is just not my thing.
I always got the feeling that he had a very good sense of proportions and designed to make a visual impact, but I never thought he had a good sense for textiles and fabrics.
From the stuff that I owned and seen, his fabrics were foremost chosen for color and texture and to make a visual impact, rather than for quality, comfort or durability.
Really, I just wish Helmut Lang came back in the picture.
If Raf is looking for an aesthetic for Calvin Klein, he could do much worse than follow the Helmut Lang playbook.


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- A walking tour of the district
- Access to the museum
- A local guide
Tour of Seattle Chinatown-International District
Weave your way through downtown Seattle's world-renowned Chinatown on an expertly guided tour that highlights history and local attractions.
What You Will Do
- Informative and interactive guided tour of Chinatown, led by a fun and friendly Wing Luke museum guide
- Insight into the history and culture of Seattle's Chinatown, including popular local attractions and little-known local favorites
- Complimentary all-day pass to explore current exhibitions at the Wing Luke Museum in the center of the Chinatown-International District
What's Included
Customer Reviews
Entertaining and educational
The tour guide was excellent. I learned some new things on the tour and our guests from Poland were impressed. Note to your Marketing staff: Some folks on the tour were in town for a food tour convention, and although they had searched for food tours, Wing Luke did not come up. I love your food tours and wish you had more of them. Also, be sure to publicize them. Thank you!
Tour of Chinatown very interesting and informative - our guide James was very knowledgeable, personable. The tour of the museum was equally interesting and added to the overall experience in understanding the immigrant experience.
The museum met our expectations, but our guide, Don, was wonderful.
Excellent guide (James). Good itinerary and was just the right length. We learned a lot!
Our tour guide was the best. He was very informative and knowledgeable. He made the experience a very memorable one.
The guide was very kind and frexble to make our tour fruitful.
Small group provided a more personal experience. Our guide was very informative and pleasant!
Very impressed with the content and quality of the exhibits. Excellent knowledgeable and welcoming guide.
My family loved the tour and learned so much from the experience. We loved the museum - it was enlightening
A very informative and well connected volunteer, Don, shared with us an abundance of interesting information about the International community and Seattle. Would definetly recommend this tour to others.
The museum is welcoming and wonderful: the exhibits, the spaces and even the scattering of seats when fatigue sets in. The tours and tour guides were dynamic, articulate and professional. There were six of us between the ages of 55 to 85, and all shared this opinion. The representative, Maya, who emailed with me ahead of time recommended the best dim sum in the area that met some physical criteria, as well as how to ensure our tour included some of the points from Bitter and Sweet because of our interest. Wing Luke is a gem.
I had the Touch of Chinatown tour with May, who was delightful and so informative! I learned a lot of history and appreciated the experience. Did not go into the rest of the museum due to time but was very pleased with the tour.
I was not at the event I am simply reporting what I heard. A couple of our members said the tour guild talked more about his own story than how the area was built and what role it has played in today's downtown tone and economy.
We had an excellent tour guide who customized the tour to our interests. We really enjoyed it. Learned a lot! I highly recommend the tour and the Wing Luke Museum!
The walking tour had a great pace, not overcrowded, and our guide was informed and interactive with the group. There was focus on the diverse immigrant's stories and their link to Seattle's early days. It was a historic tour of importance and stuck with the family in thoughtful ways that want to bring us back to Chinatown and The International Dist. We as a family are recommending it and on a side-note we walked the Underground the same day and preferred Chinatown's tour.
I was very impressed with the level of information provided by the tour guide and how well any questions were answered.
Great guide with lots of interesting information, open to questions. Very enjoyable tour of part of our city's culture and history.
Tour guide May was very knowledgeable and interesting, and I enjoyed seeing this part of Seattle and learning more about Seattle's history that not every tourist finds out.
Our guide was very knowledgable, and walked us around the Chinatown neighborhood and gave us a good feel for its history. She actually made the history of the area come alive for us. Also enjoyed the Wing Luke Museum before the tour; very well done and comprehensive.
We really like how she handle the visitors. More can be commented on the part of Chinatown as opposed to Japan town.
The guide John was amazing and very knowledgeable, friendly. He showed us parts of Chinatown which you would just not see by just walking around. If you have the time then this is a must do tour on a visit to Seattle!!
Our guide was personable and friendly! We learned a lot that we did not know. Thank you!
Our tour guide, Maya, was fantastic. The museum is beautiful and I really appreciate the way the institution works with communities to develop the exhibits. I learned a lot and will definitely return.
Our group received personal attention and a very candid professional tour of Chinatown. We learned history politics and economics of past and present day Chinatown along with an emphasis on locales mentioned in Hotel on the Corner of Bitter and Sweet.
Our young guide was very knowledgeable and wove in very interesting stories. My three friends and I all enjoyed it very much.
The tour was informative and interesting and the guide was knowledgeable.
Additional Information
- To Know:
Bring comfortable walking shoes and a raincoat or umbrella if its raining.
- Refund Policy:
- All sales are final
February, 2017
Please select a date from above
More Activities From This Operator
Learn Bruce Lee's full story through this exhibition that tells the story of his life in fascinating detail. Follow the legend as he grew from waiter at a local restaurant to global movie star.
Experience a new world when you step into Wing Luke Museum: a space designed to inform and delight with stories of the Asian-Pacific communities in Seattle.
Discover the man behind the legend with a tour of Bruce Lee's life and work at a museum exhibit all about the master. Get an insider's view into the world of his movies and personal life.
Top Destinations
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Featured Products
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This module displays a short excerpt from articles in a selected category or section, or from a specified list of articles, with link and optional thumbnail image.
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This plugin allows you to restrict selected pages on your site from view. Until the user enters a code or codes of your choice, they see the page covered by a modal backdrop.
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What can you give God today to make him smile? Simply offer him your heart—that means all of you, body, mind and spirit—perhaps for the first time or maybe for the fiftieth time. Nothing moves God like those he loves (see John 3:16) fully surrendering and gratefully responding to his love.
Read: Psalm 147 // Focus: Psalm 147:11
You and I have had the joy of being given something by another that just made our heart sing—a birthday present, a Christmas gift, a Valentine's Day card or some other expression of love, appreciation or gratitude. But what can you give to God to move his heart? How do you make the Lord happy? He has everything he wants and can create what he doesn't have.
God is all-powerful—after all, he created universe beyond universe beyond universe, and all the planets and stars within them, even calling all the stars by name: "He determines the number of the stars and calls them each by name." (Psalm 147:4)
God knows everything there is to know—there is no limit to either his power or his understanding: "Great is our Lord and mighty in power; his understanding has no limit." (Psalm 147:5)
God has fixed up this little globe called earth to run amazingly well, sustaining its ecological systems: "He sends his command to the earth; his word runs swiftly. He spreads the snow like wool and scatters the frost like ashes. He hurls down his hail like pebbles. Who can withstand his icy blast? He sends his word and melts them; he stirs up his breezes, and the waters flow. (Psalm 147:15-18)
God has even ordered provision for the daily needs of his earthly creatures: "He covers the sky with clouds; he supplies the earth with rain and makes grass grow on the hills. He provides food for the cattle and for the young ravens when they call." (Psalm 147:8-9)
So accurately, abundantly and consistently does God care for the earth's higher inhabitants that their utter and ceaseless gratitude is only fitting: "Sing to the Lord with thanksgiving; make music to our God on the harp" (Psalm 147:7)
What, then, can you give to a God who has it all and does it all? Only your fear and your hope, that's what! What satisfies God to the core of his being is the fear that arises not out of terror, but from the kind of reverence and respect that comes from knowing that he is the giver and sustainer of life itself, the rightful owner of Planet Earth and rightful ruler of your life.
What causes God pleasure is the hope that looks to him for protection, peace and provision: "For he strengthens the bars of your gates and blesses your people within you. He grants peace to your borders and satisfies you with the finest of wheat. (Psalm 147:13-14)
What causes God pleasure is the patience that waits for him to execute justice and fairness: "He heals the brokenhearted and binds up their wounds." (Psalm 147:3)
What causes God pleasure is the trust that expects him to fulfill his good purposes to all those who belong to him: "He has revealed his word to Jacob, his laws and decrees to Israel. He has done this for no other nation; they do not know his laws." (Psalm 147:19-20).
What gift can you offer to the one Being who truly has it all? Just your very life, that's all.
Do you want to bring a smile to God's face today? I think you know what to do!


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Owner Financing Homes in 65740, MO
|12 Listings Found
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352 Presbyterian St, Hollister, MO, 65672Details »
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Branson, MO, 65616Details »
mobiles upon final approval & accepted contract. If you are looking for a larger investment opportunity
331 Evergreen, Hollister, MO, 65672Details »
Owner Finance Home in HOLLISTER. Home has 1200 Sq Ft, with 4 beds, 3.0 baths.. Check out
1234 clark, Hollister, MO, 65672Details »
deck for only $30,000 extra (Boat slip directions in images). Owner financing available to qualified
Branson West, MO, 65737Details »
Financing, 3.5 % down with FHA Financing! Possible short term owner finance with $5,000 down and $1200/mo
11 Athens Ln, Galena, MO, 65656Details »
and turn around prior to their residence. thank you. Owner will consider owner financing with 10% down
4192 State Hwy Jj, Sparta, MO, 65753Details »
) at a discount at $58,000 for both. Owner financing possible email address above or call 417-725-XXXX
Ozark, MODetails »
OWNER FINANCED--2.36 Acres one mile from Bull Shoals Lake-Owner Financed! The land for sale
Diamond City, ARDetails »
on NW corner, & new private access road has been constructed for this property. Owner financing
321 Locust Dr, Lead Hill, AR, 72644Details »
/26 and that only owner occupant offers will be considered until 2/1. Loads of potential in this spacious 4 Beds
1263 West Butterfield Dr, Nixa, MO, 65714Details »
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White striping is a condition in broiler chickens characterized grossly by the occurrence of white striations, seen parallel to the direction of muscle fibers, on broiler breast fillets and thighs. Based on visual evaluation of the intensity of white striping, breast fillets can be categorized into normal (NORM), moderate (MOD), and severe (SEV) categories. This study was undertaken to evaluate the details of changes in histology as well as proximate composition occurring in the fillets with respect to the 3 degrees of white striping. In experiment 1, representative breast fillets for each degree of white striping (n = 20) were collected from 45-d-old broilers, approximately 2 h postmortem. From each fillet, 2 skeletal muscle samples were obtained and fixed in 10% neutral buffered formalin. To identify and differentiate the histological changes, slides were prepared and stained using hematoxylin and eosin, Masson's Trichrome, and Oil Red O stains. In experiment 2, samples with 3 degrees of white striping were collected from 57-d-old birds for conducting proximate analysis. Major histopathological changes observed in the MOD and SEV samples consisted of loss of cross striations, variability in fiber size, floccular/vacuolar degeneration and lysis of fibers, mild mineralization, occasional regeneration (nuclear rowing and multinucleated cells), mononuclear cell infiltration, lipidosis, and interstitial inflammation and fibrosis. Microscopic lesions were visually scored for degeneration and necrosis, fibrosis, and lipidosis. The scale used to score the samples ranged from 0 (normal) to 3 (severe). There was an increase (P < 0.05) in mean scores for degenerative or necrotic lesions, fibrosis, and lipidosis as the degree of white striping increased from NORM to SEV. The results from the histopathological study were supported by the findings from proximate analysis confirming that the fat and protein contents of muscle increased (P < 0.05) and decreased (P < 0.05), respectively, as the degree of white striping increased. In conclusion, the histopathological changes occurring in white striping indicate a degenerative myopathy that could be associated with increased growth rate in birds.
Visual appearance is the single meat quality that decides the purchase of a packed meat product in a grocery store. Any deviation from the normal appearance will result in the rejection of the product in meat market, irrespective of other superior qualities. Recently, Kuttappan et al. (2012c) reported that white striping is a condition that could reduce the consumer acceptance and purchase intent for boneless skinless broiler breast fillets. The condition is characterized by white striation seen parallel to the direction of muscle fibers in broiler breast fillets, and there can be varying severity (Figure 1). Based on that, fillets can be classified as normal (NORM), moderate (MOD), and severe (SEV; Kuttappan et al., 2012c). White striping is associated with heavier BW or enhanced growth rate in birds (Bauermeister et al., 2009; Kuttappan et al., 2012a). Kuttappan et al. (2012a) also reported that the occurrence of SEV degree of white striping is associated with higher fat content in broiler breast fillets of birds from the same strain fed with same diet formulation. Currently, producers are concerned about the influence of white striping on the poultry meat market. However, little is known about the tissue changes associated with the occurrence of the condition in broilers and the possible etiology.
Gross, microscopic, and subcellular properties of skeletal muscle may vary depending on the species, strains, anatomical location, stage of development, or even the different portions within the same muscle (Mahon et al., 1984; Mahon, 1999). Also, the appearance of white regions in meat will give a primary impression of marbling to the consumer, as in the case of beef or pork. This was reflected in cases of white striping evaluated by consumers (Kuttappan et al., 2012c). Alternatively, some of the earlier studies reported that the occurrence of white striations on broiler breast fillets was due to conditions like hereditary muscular dystrophy (Asmundson and Julian, 1956; Julian and Asmundson, 1963) and nutritional myopathy due to the deficiency of vitamin E and associated nutrients (Dam et al., 1952; Machlin and Shalkop, 1956; Klasing, 2008). In fact, the occurrence of pale streaks may be a manifestation of mineralization or infiltration of collagen or fat as a sequel to myofiber necrosis due to any cause (Valentine and McGavin, 2012). The details of tissue changes taking place in birds with white striping need to be explored to determine whether it is a variation within a normal physiological range or a muscle abnormality. According to Valentine and McGavin (2012), the cytoarchitectural characteristics of skeletal muscle are best evaluated by microscopic examination. We hypothesize that there may be differences in microscopic lesions between the NORM, MOD, and SEV degrees of white striping that could have resulted in a change in proximate composition reported by Kuttappan et al. (2012a). The purpose of this study was to identify, quantify, and compare the histological lesions seen in broiler breast fillets with NORM, MOD, and SEV degrees of white striping. Also, a comparison was made in lesions seen on different portions within the breast fillets as well as various other muscles. The proximate composition of breast fillets with NORM, MOD, and SEV degrees was also determined to support the histological findings. Furthermore, attempts were made to derive speculations about the etiology of the tissue changes associated with the occurrence of white striping.
Experiment 1
Muscle samples for the histologic study were collected from birds processed at 45 d of age. The samples used in the present study were collected from birds (market age) processed under the commercial-style inline processing system (Mehaffey et al., 2006) at University of Arkansas Poultry Processing Pilot Plant. All the birds were withdrawn from feed for 10 h before slaughter, but were given free access to water. During processing, the birds were electrically stunned, exsanguinated by severing the left carotid and jugular vein, soft scalded, defeathered, and manually eviscerated. The carcasses were hot deboned (without chilling) at 30 min postmortem. Because the condition is present at the time of processing, carcasses were hot deboned so that samples for the histology could be collected with minimal autolytic changes. The left breast fillet from each bird was screened to determine the degree of white striping (Kuttappan et al., 2012c). Briefly, the fillets were categorized as NORM, MOD, and SEV based on the size and distribution of the gross white striations on the surface. Fillets with apparently no white striations were considered to be NORM. Those fillets with white striations generally <1 mm thick, but readily observed on the fillet surface were considered to have a MOD degree of white striping. The SEV fillets had thick white striations (generally >1 mm thick) that covered a greater area of the fillet surface. After scoring for the degree of white striping, the muscle samples were collected from the cranial region on the ventral surface or from the skin side of the left-side breast fillets (pectoralis major) of 60 birds (n = 20/each degree of white striping). From another 18 birds (n = 6/each degree of white striping), samples were collected from the ventral and dorsal (bone-side) surfaces of the cranial region of breast fillets (pectoralis major), tenders (pectoralis minor), thighs (iliotibialis), and drumsticks (gastrocnemius) of each bird to compare the changes occurring in other muscles. Two muscle sections were collected from each muscle. Special attention was given to keep the sampling site consistent throughout the study. All the muscle sections were cut along the direction of muscle fibers and fixed in 10% buffered neutral formalin. Later, the tissues were embedded in paraffin, sectioned at 4 μm, and stained with hematoxylin and eosin (H & E) stain. Three tissue sections were prepared from each muscle sample collected. The H & E stained slides were mainly used to evaluate the myopathic lesions in the tissue. The muscle tissues were also stained with Oil Red O and Masson's Trichrome stains to confirm the presence of lipid and collagen, respectively. The Oil Red O staining is specific for fat, where fat is shown in red and the nuclei are blue (Jones, 2002a). Masson's Trichrome stains the muscle, collagen, and nuclei with red, blue, and blue-black, respectively (Jones, 2002b). The degree of myopathic lesions, fibrosis, and lipidosis were quantified by visually scoring the tissue slides under bright field microscopy. The histopathological score was based on a scale ranging from 0 to 3, with normal (0), mild (1), moderate (2), and severe (3; Figure 2). The histological lesions were evaluated separately by 4 veterinary pathologists, and the scoring of histopathological lesions was performed at California Animal Health and Food Safety Laboratory, Tulare.
Experiment 2
Muscle samples for proximate analysis were collected from 45 birds (n = 15 for each degree of white striping), of 57 d old. The birds were processed and the fillets were scored for the degree of white striping as explained in experiment 1. The left-side breast fillets were longitudinally split into equal halves of dorsal and ventral sections. About 50 g of meat was collected from the cranial end of the dorsal and ventral halves of each fillet. Proximate composition of the raw breast fillets was determined at the University of Arkansas Central Analytical Laboratory. Breast fillet samples were weighed in plastic containers and placed in a freeze-dryer (Virtis Genesis, Gardiner, NY) set at −10°C, and were allowed to freeze-dry for 8 d until the pressure reached 0 mm of mercury. Fat and protein contents of the freeze-dried samples were estimated using ether extraction (AOAC #920.39C) and combustion (AOAC #990.03) methods, respectively (AOAC, 1990), and were reported as percentages on a DM basis.
Statistical Analysis
The myopathic lesions, fibrosis, and lipidosis scores as well as the proximate composition (dorsal or ventral portions) of the muscle samples were analyzed to evaluate the differences between of NORM, MOD, and SEV degrees of white striping. The data were analyzed using ANOVA (SAS Institute Inc., Cary, NC), and means were separated with Tukey's honestly significant difference test with P < 0.05 considered as significant. Individual birds were considered as the experimental unit for the entire analysis.
In the present study, gross lesions on the dorsal and ventral surfaces of the fillets (pectoralis major), as well as various other muscles such as tenders (pectoralis minor), thighs (iliotibialis), and drumsticks (gastrocnemius) were compared. Within the same fillet, it was found that the severity of the condition was greater toward the cranial end where the fillet was thicker compared with the caudal portion (Figure 1). Even though the ventral (skin-side) surface of MOD and SEV fillets showed distinct lines, the gross lesions were comparatively less on the dorsal (bone-side) portion. However, white flecks of varying size were seen throughout the fillet. Furthermore, the occurrence of white striations was more distinct on fillets and thighs muscles, whereas it was less apparent on tenders and drumsticks. The histopathological analysis showed profound degenerative myopathic lesions along with replacement of chronically damaged muscle with adipocytes and fibrosis in the muscle tissue with a higher degree of white striping (Figure 2). The microscopic lesions included floccular/vacuolar degeneration, lysis, mild mineralization, occasional regeneration (nuclear rowing and multinucleated cells), and interstitial inflammation along with fibrosis. There were multiple rounded hypereosinophilic fibers with loss of cross striation and internalization of nuclei. The interstitium showed multifocal edema with infiltration by lymphocytes and macrophages. There were several muscle fibers that were fragmented and undergoing phagocytosis. The muscle cells seemed to have variability in fiber size even though it was difficult to confirm that in the face of degeneration and regeneration. Both acute and chronic (polyphasic) changes were observed in same tissue sections. Increased severity (MOD and SEV) of the white striping was related to increased chronicity of myopathic lesions although the NORM muscle occasionally showed hypereosinophilic fibers with loss of cross striations, internalization of nuclei, and few infiltrates of lymphocytes and macrophages. The analysis of the histopathological score revealed that as the degree of white striping increased, there was a significant (P < 0.05) increase in the occurrence of chronic myopathic lesions along with lipidosis and fibrosis (Figure 3). Furthermore, the histopathological score from different muscle samples showed that the fillets (dorsal and ventral surfaces) and thigh muscle had a significant (P < 0.05) increase in the myopathic lesions with respect to an increase in the degree of gross lesions (from NORM to MOD and SEV) of the breast fillets (Table 1). This histopathological observation was in accordance with the gross lesions observed in the respective muscle samples as well.
Comparison of the histopathological score (0/normal to 3/severe) for myopathic lesions (hematoxylin and eosin staining) associated with white striping in different muscles
|Histopathological score2
|NORM (n = 6)
|MOD (n = 6)
|SEV (n = 6)
|Pooled SE
|Histopathological score2
|NORM (n = 6)
|MOD (n = 6)
|SEV (n = 6)
|Pooled SE
a–cMeans within each column with different letters are significantly different (P < 0.05).
1NORM = normal (no white striping); MOD = moderate degree; SEV = severe degree.
2Scale used to assess myopathic lesions (hematoxylin and eosin staining): 0 = normal, 3 = severe.
The results from the proximate analysis of both the dorsal and ventral surface samples from the broiler breast fillets with different degrees of white striping were in concurrence with the histopathological observations. The samples collected from the ventral surface of the fillets showed an increase (P < 0.05) in the fat content (% of DM) as the degree of white striping increased (Figure 4). Interestingly, there was no (P > 0.05) difference in the fat content in the meat samples collected from ventral surface of MOD and SEV, although these 2 had a higher (P < 0.05) fat content compared with NORM. Furthermore, the ventral surfaces of the MOD and SEV fillets had a higher (P < 0.05) fat content than the corresponding dorsal surfaces, whereas there was no difference in fat content due to location within the NORM fillets. In addition, as the fat content increased associated with an increase in the degree of white striping, there was a corresponding decrease in protein content. The dorsal and ventral surfaces on the NORM fillet had higher (P < 0.05) protein content compared with that of the MOD and SEV fillets (Figure 5). Moreover, there was a difference (P < 0.05) in the protein content in the dorsal and ventral surfaces of SEV fillets, even though a similar difference was not seen in NORM and MOD fillets. The relationship between the mean (average of the dorsal and ventral portions) protein and fat content of the fillets can be appreciated from Figure 6. There was large variation in the protein and fat contents in both MOD and SEV fillets, which could have resulted in the significant negative correlation. The negative correlation implies that the protein in the muscle might be getting replaced by fat as suggested by the histopathological findings.
The present study indicates that the severe degrees of white striping are histopathologically characterized by chronic myopathic lesions. The polyphasic (both acute and chronic) changes in the same sections suggested continuous and ongoing exposure to the causative insult (Valentine and McGavin, 2012). According to Dubowitz (1985), myopathic lesions are nonspecific, which could be occurring due to several neuromuscular disorders (Valentine, 2008). Therefore, the precise etiology of white striping cannot be confirmed. However, the possible etiology of white striping can be speculated based on the information available so far. Previous studies on white striping suggest that it could be an emerging condition that is closely associated with the increased growth rate and heavier breast fillets in broilers (Bauermeister et al., 2009; Kuttappan et al., 2012a,b, 2013). Wilson et al. (1990) reported that the rapid growth rate in turkeys may have caused the muscle tissues to outgrow the limit of the supporting systems leading to a condition called focal myopathy, which is different from deep pectoral myopathy or inherited muscular dystrophy. There are reports of muscular damage in turkeys that may be due to ischemia associated with rapid growth rate (Sosnicki et al., 1989; Sosnicki et al., 1991). Furthermore, Mahon (1999) opined that intense selection for rapid growth rate in birds could have accidentally been accompanied by the selection for inadequate capillary/fascial growth or muscle fiber defects leading to myopathic changes referred to as growth-induced myopathy. Also, there is a chance of reduced oxygen supply to breast muscle as a result of lower capillary density in fast-growing chickens (Hoving-Bolink et al., 2000). Furthermore, the lack of sufficient blood supply could result in accumulation of metabolic waste products (MacRae et al., 2006), leading to oxidative stress and tissue damages. The increased levels of serum enzymes indicating muscle damage along with myopathic changes was observed in birds with higher BW (MacRae et al., 2006). The damage associated with higher growth rate can also lead to defective cation regulation resulting in increased level of sodium, potassium, magnesium, and calcium in muscle tissue (Sandercock et al., 2009). An increased level of calcium in muscle tissue can initiate several tissue changes including the activation of intracellular proteases or lipases resulting in myopathic changes (Jackson et al., 1984; Mahon, 1999; Sandercock and Mitchell, 2003; Mitchell and Sandercock, 2004; Millay et al., 2009). Furthermore, the inflammatory response during degeneration of myofibers will attract neutrophils, activated macrophages, and T-lymphocytes to the area, eventually resulting in phagocytosis of cell debris and release of factors such as cytokines, prostaglandins, and so on (Prisk and Huard, 2003; Smith et al., 2008). Also, the factors released from the inflammatory cells will activate of satellite cells initiating the regeneration of damaged myofibers (Kääriäinen et al., 2000). When the insult causing the muscle damage is "too great" or "too acute" or "too continuous," the regenerative process will be ineffective (Mahon, 1999), eventually leading to fatty degeneration (Natarajan et al., 2010). In that case, the pluripotent stem cells in the muscle tissue differentiate to fibroblasts or adipocytes (Asakura et al., 2001; Wada et al., 2002; Shefer et al., 2004; Brack et al., 2007), due to the influence of the degenerating muscle fiber (Hosoyama et al., 2009), which ultimately results in fibrosis and lipidosis in the tissue.
In case of white striping, the enhanced growth rate associated with severe degrees could have resulted in overstretching or ischemia in tissues, resulting in muscle damage and initiation of reparative responses. Later, these reparative or regenerative attempts failed and took a different phase leading to fatty degeneration. This could be why the MOD and SEV fillets have a higher lipidosis and fibrosis compared with the NORM. The presence of the acute and chronic myopathic lesions in the same tissue confirms the chronic ongoing insult that may have resulted in ineffective regenerative process. It should be noted that the gross lesions are more pronounced toward the cranial region of the ventral surface of the fillets where the fillets show maximum thickness. Furthermore, the myopathic lesions were higher in the ventral portion of the fillets where the convexity or stretching is greater compared with the dorsal portion. Interestingly, there were differences in the occurrence of white striping in different muscles (Table 1). This implies that the development of lesions may be related to differences in the distribution of muscle fiber types. For example, it has been reported that white muscle fibers are predominately seen in pectoralis major (Smith and Fletcher, 1988) and iliotibilais muscle (Brackenbury and Williamson, 1989), whereas the gastrocnemius is primary composed of red muscle fibers (Julian and Asmundson, 1963). The present study showed a major difference in the occurrence of gross and microscopic white striping lesions in iliotibialis and pectoralis major (mainly toward the ventral portion), suggesting that the white fibers may be more susceptible to the condition. The selection of enhanced growth rate could have adversely affected the capillary supply to musculature leading to an increased percentage of white or glycolytic fibers in various skeletal muscles (Soike and Bergmann, 1998a). Furthermore, these glycolytic muscle fibers in fast-growing birds may have reduced calcium transport abilities, which make them vulnerable to pathologic changes due to the increased energy demand and production of lactate (Soike and Bergmann, 1998b). In addition, the difference in the growth rate for various muscle fiber types (Ono et al., 1993) may also be contributing to differences in the myopathic changes in these muscles. Nonetheless, the tremendous growth rate in modern broilers could result in greater incidence of higher degrees of white striping in the industry, leading to economic loss due to the rejection of poultry meat by consumers (Kuttappan et al., 2012c). So, further studies, along with comparison of white striping to various known muscular abnormalities in poultry, are required to confirm the etiology and the possible ways to reduce the incidence of the condition in poultry meat.
To conclude, the occurrence of MOD and SEV degrees of white striping is histologically characterized by chronic myopathic lesions like loss of cross striations, variability in fiber size, floccular/vacuolar degeneration and lysis of fibers, mild mineralization, occasional regeneration (nuclear rowing and multinucleated cells), mononuclear cell infiltration, lipidosis, and interstitial inflammation and fibrosis. The presence of polyphasic lesions on the same muscle sample indicates the chronic and ongoing insult causing these lesions. The increased incidence of these lesions is associated with changes in the proximate composition of meat, especially a decrease in protein and an increase in fat percentages. The occurrence of tissue changes is more frequent toward the cranio-ventral surface of the fillet compared with the other regions. Furthermore, lesions are more apparent in pectoralis major (fillets) and iliotibilais muscle compared with the pectoralis minor (tenders) and gastrocnemius muscles. Based on the tissues changes and the observations from previous studies, white striping could be an emerging issue in poultry meat industry and appears to be associated with enhanced growth rate in birds.
The authors are appreciative for the support of Cobb-Vantress Inc. (Siloam Springs, AR) and the University of Arkansas Division of Agriculture (Fayetteville) throughout this project.


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Top Definition
A Brazilian slang term for a woman with nice body and ugly face.
Aquela menina é raimunda, feia de cara e boa de bunda!
That girl is raimunda, ugly face an nice ass.
That girl is raimunda, ugly face an nice ass.
by mikwat May 14, 2004
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Separate names with a comma.
Discussion in 'News / Current Events' started by Crabtownboy, May 1, 2010.
I wish the news were better here in the US.
The study only looked at adult mortality rates. While the US can do better in this area, this one figure doesn't say a whole lot about the health care system as a whole. I'd say it is more of a statement about violent crime, motor vehicle accidents and war than it is about managing chronic disease.
It is also easy for wealthy countries with small populations and small land masses to perform well on health metrics because the cost of delivery and socioeconomic contributors factors of health are significantly easier to manage.
Great, may I suggest a relocation of all political liberals from the USA to there? Should be win-win, as I see it.
Or you guys could just all move to South Carolina. Should be a good fit.
I prefer Texas- they know how to fight and win.:laugh: