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POPULATION PHARMACOKINETICS RAYMOND MILLER, D.Sc. Pfizer Global Research and Development RAYMOND MILLER, D.Sc. Pfizer Global Research and Development
Population Pharmacokinetics Definition Advantages/Disadvantages Objectives of Population Analyses Impact in Drug Development
Population pharmacokinetics describe The typical relationships between physiology (both normal and disease altered) and pharmacokinetics/pharmacodynamics, The interindividual variability in these relationships, and Their residual intraindividual variability. Sheiner-LB Drug-Metab-Rev. 1984; 15(1-2): Definition
E.g.: A simple Pk model Ri = infusion rate Cl = drug clearance k =elimination rate constant = measurement error, intra- individual error Drug Conc Time N(0, )
Definition Drug Conc Time
Cl = metabolic clearance + renal clearance Cl = CCr Drug Clearance Creatinine Clearance Drug Conc Time Definition
Cl = metabolic clearance + renal clearance Cl = CCr Drug Clearance Creatinine Clearance N(0, ) Definition
Graphical illustration of the statistical model used in NONMEM for the special case of a one compartment model with first order absorption. (Vozeh et al. Eur J Clin Pharmacol 1982;23: )
Objectives 1. Provide Estimates of Population PK Parameters (CL, V) - Fixed Effects 2. Provide Estimates of Variability - Random Effects Intersubject Variability Interoccasion Variability (Day to Day Variability) Residual Variability (Intrasubject Variability, Measurement Error, Model Misspecification)
Objectives 3. Identify Factors that are Important Determinants of Intersubject Variability Demographic: Age, Body Weight or Surface Area, gender, race Genetic: CYP2D6, CYP2C19 Environmental: Smoking, Diet Physiological/Pathophysiological: Renal (Creatinine Clearance) or Hepatic impairment, Disease State Concomitant Drugs Other Factors: Meals, Circadian Variation, Formulations
Advantages Sparse Sampling Strategy (2-3 concentrations/subject) –Routine Sampling in Phase II/III Studies –Special Populations (Pediatrics, Elderly) Large Number of Patients –Fewer restrictions on inclusion/exclusion criteria Unbalanced Design –Different number of samples/subject Target Patient Population –Representative of the Population to be Treated
Disadvantages Quality Control of Data –Dose and Sample Times/Sample Handling/ Inexperienced Clinical Staff Timing of Analytical Results/Data Analyses Complex Methodology –Optimal Study Design (Simulations) –Data Analysis Resource Allocation Unclear Cost/Benefit Ratio
Drug Conc Time Models are critical in sparse sampling situations:
Drug Conc Time Models are critical in sparse sampling situations:
Drug Conc Time Models are critical in sparse sampling situations:
Drug Conc Time Models are critical in sparse sampling situations:
Drug Conc Time Models are critical in sparse sampling situations:
Drug Conc Time Models are critical in sparse sampling situations:
Study Objectives To evaluate the efficacy of drug treatment or placebo as add on treatment in patients with partial seizures.
Data Structure
Count Model represents the expected number of events per unit time E(Yij)= i t ij The natural estimator of is the overall observed rate for the group.
Suppose there are typically 5 occurrences per month in a group of patients:- =5
The mean number of seizure episodes per month (λ) was modeled using NONMEM as a function of drug dose, placebo, baseline and subject specific random effects. Baseline = estimated number of seizures reported during baseline period Placebo = function describing placebo response Drug = function describing the drug effect = random effect
Sub-population analysis Some patients are refractory to any particular drug at any dose. Interest is in dose-response in patients that respond Useful in adjusting dose in patients who would benefit from treatment Investigate the possibility of at least two sub- populations.
Population A (p) Population B (1-p) Mixture Model A model that implicitly assumes that some fraction p of the population has one set of typical values of response, and that the remaining fraction 1-p has another set of typical values
Final Model
Expected percent reduction in seizure frequency Monte Carlo simulation using parameters and variance for Subgroup A 8852 individuals (51% female) % reduction from baseline seizure frequency calculated Percentiles calculated for % reduction in seizure frequency at each dose
Conclusions A comparison of the dose-response relationship for gabapentin and pregabalin reveals that pregabalin was 2.5 times more potent, as measured by the dose that reduced seizure frequency by 50% (ED50). Pregabalin was more effective than gabapentin based on the magnitude of the reduction in seizure frequency (Emax) Three hundred clinical trials for each drug were simulated conditioned on the original study designs. Each simulated trial was analyzed to estimate % median change in seizure frequency. The observed and model-predicted treatment effects of median reduction in seizure frequency for gabapentin and pregabalin are illustrated for all subjects and for responders. Data points represent median percentage change from baseline in seizure frequency for each treatment group (including placebo). The shaded area corresponds to predicted 10th and 90th percentiles for median change from baseline in seizure frequency.
Relationship Between %Change in Seizure Frequency (Relative to Baseline) and Daily Dosage of Gabapentin and Pregabalin Dose-response model in epilepsy using pooled analysis of 4 gabapentin studies + 3 pregabalin studies
Relationship Between %Change in Seizure Frequency (Relative to Baseline) and Daily Dosage of Gabapentin and Pregabalin in Responders to Treatment Dose-response model in epilepsy using pooled analysis of 4 gabapentin studies + 3 pregabalin studies
Clinical Trial Simulation Used to assess how different design and drug factors may affect trial performance. May be viewed as an extension of statistical design evaluation.
Planning Phase 2 POC for Alzheimer's Disease Drug Because the mechanism of action of CI-1017 was untested clinically, the principle objective of the clinical study was to ascertain whether CI-1017 improved cognitive performance at least as fast and as well as tacrine. This would be considered proof of concept (POC).
Typical Effectiveness Trials (AD) Parallel group design Two to four treatment groups + placebo Powered to detect 3 point improvement in ADAS-Cog Minimum 12 weeks of treatment Require about 80 subjects per dose group to have 90% power (2 sided 50% sig. Level)
Simulation Model
Drug effect models considered in simulations study. Parameters characterizing the model are displayed in the individual panels (Lockwood et al.)
TRIAL DESIGN Design numbe r Design descriptionNumber of sequences Subjects per sequence Number of treatments periods Period length (weeks)Measurements per period 16X6 Latin Square X3 Incomplete block Parallel group X4 Incomplete block X3 Incomplete block with 2 parallel groups 88Seq 1-6: 3 Seq 7-8: 1 Seq 1-6: 4 Seq 7-8: X4 Latin Square X4 Latin Square with 2 parallel groups 610Seq 1-4: 4 Seq 5-6: X4 Latin Square415442
DATA EVALUATION DOES THE DRUG WORK? AOV to test null hypothesis of no drug effect Rejection of null hypothesis judged correct Dose trend test IS THE SHAPE MONOTONIC OR U-SHAPED? Similar to the above two steps Non-positive trial pattern classified as flat Inference between monotonic and u-shaped based on highest dose having best mean outcome.
SIMULATION 100 Trial simulations Pharsight trial simulator (TS2) Data from each trial analyzed Conclusions scored
DRUG EFFECT Design number 876 Dose response shape Linear Emax Smax U-shape AVERAGE Design number 6: 4X4 Latin Square, 3 weeks per treatment. Design number 7: 4X4 Latin Square with 2 parallel groups, Design number 8, 4X4 Latin Square, 4 weeks per treatment Percent of 100 trials (power) that detected a drug effect for design number 6, 7 and 8.
SHAPE Percent of 100 trials (power) that correctly identified dose- response shape for design number 6, 7 and 8 Design number876 Dose response shape Linear Emax Smax U-shape AVERAGE806269
Simulation Conclusions Design 4x4 LS with 4-week periods using bi-weekly measurements Was best among alternatives considered for detecting activity and identifying DR shape Met minimum design criteria (80% average power)
Results 4x4 LS design was accepted, conducted, and analyzed more-or-less as recommended Unfortunately, drug didnt work But we were able to find this out more quickly and with less resources than with conventional design
Gabapentin – Neuropathic Pain NDA Two adequate and well controlled clinical trials submitted. Indication – post-herpetic neuralgia Trials used different dose levels 1800 mg/day and 2400 mg/day 3600 mg/day The clinical trial data was not replicated for each of the dose levels sought in the drug application
FDAMA 1997 FDA review staff decided to explore whether PK/PD analyses could provide the confirmatory evidence of efficacy. based on relevant science, that data from one adequate and well controlled clinical investigation and confirmatory evidence (obtained prior to or after such investigation) are sufficient to establish effectiveness.
SIMULATION 100 Trial simulations Pharsight trial simulator (TS2) Data from each trial analyzed Conclusions scored
Gabapentin Study Designs for PHN Used all daily pain scores (27,678 observations) Exposure-response analysis included titration data for within-subject dose response
Gabapentin Response in PHN Time Dependent Placebo Response, Emax Drug Response and Saturable Absorption,
Results Summary statistics showed pain relief for both studies at different doses concur. M & S showed pain scores for both studies can be predicted with confidence from the comparative pivotal study (cross confirming).
Conclusion The use of PK/PD modeling and simulation confirmed efficacy across the three studied doses, obviating the need for additional clinical trials. Gabapentin was subsequently approved by FDA for post-herpetic neuralgia The package insert states pharmacokinetic/pharmacodynamic modeling provided confirmatory evidence of efficacy across all doses
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The average in-state tuition for full time undergraduate students in math schools in Pasadena during the 2009 - 2010 school year was $20,368.00. The average tuition was $21,119.00 for non-residents studying in California.
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Black History Month -Recognizing Dr Maya Angelou
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India's loudest news anchor quits
India's many famous TV horde has resigned, promulgation amicable media into a frenzy and triggering conjecture he might be about to launch his possess channel or even join Fox News.
Arnab Goswami, 43, quit on Tuesday after 10 years hosting a nightly primary time uncover on Times Now, a channel where he also served as editor-in-chief.
Goswami, whose warlike character done him a domicile name, announced his depart in a staff assembly during a broadcaster's domicile in Mumbai, a Times Now worker who attended a assembly told CNNMoney.
Speaking on condition of anonymity since a information was confidential, a worker pronounced Goswami told about 50 reporters and editors that he wanted to do "something bigger."
Times Group, that owns Times Now and a Times of India newspaper, did not respond to a ask for comment. Times Now competes with CNNNews18, CNN's India affiliate.
Goswami's assertive proceed towards guest on The Newshour — customarily cheering them down or cheering over them — saw Times Now fire to a tip of Indian radio ratings.
It also warranted him countless detractors and lampooners (including, on mixed occasions, John Oliver on Last Week Tonight.)
India's star horde eschewed Twitter (TWTR, Tech30) and Facebook (FB, Tech30) though his name was a tip trending tenure on both amicable media platforms when reports of his abdication began to emerge.
His depart stirred a call of Twitter humor, even as many hailed a anger over his abdication as a covenant to his popularity.
"End of an epoch with Arnab quitting Times Now. we shall observe one notation sound to symbol a occasion," one user wrote.
"Impact will be in decibels," quipped another.
Times Now contingency now be desperately acid for panelists who know how to finish a sentence.
— Ramesh Srivats (@rameshsrivats) November 1, 2016
Arnab quit Times Now. 9 PM to 10 PM will be celebrated as Earth Hour.
— Trendulkar (@Trendulkar) November 1, 2016
Alongside a jokes and messages of indebtedness was copiousness of gibberish about what Goswami will do next.
He has formerly hinted during a enterprise to place India's media on a tellurian stage, saying final year during a discussion orderly by broadcaster Russia Today that a "hegemony of Western media has to end."
Indian journal Business Standard cited unknown sources within Times Now as observant their former trainer might start a new channel with an Indian politician and American media nobleman Rupert Murdoch, or join Fox News.
But for now, as Goswami's signature line goes: "The republic wants to know."
Article source: http://rss.cnn.com/~r/rss/edition_business/~3/TTD_HCKtW8U/index.html


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Unique renovated Kiviloo Manor! Manor's history goes back to 15th century, when it was built as a knight's manor. On the 17th to 18th century it belonged to many different owners, from 1842 it belonged to the Stackelberg family until its expropriation in 1919. The Manor has largely been renovated between 2010 - 2013. The manor is located 35 km from Tallinn, in Raasiku Rural Municipality, 30 minutes car ride by recently repaired asphalted road. Surrounding nature is spectacular, manor is located in a naturally stunning setting on the bank of the Jõelähtme River. The park surrounding the manor house is oriented towards the river, the park is exceptional and full of nature! MAIN MANOR: On the first floor, there is an exceptional hallway, huge dining room with the fireplace, living room, fully equipped professional kitchen and rooms for the personal. From the first floor you will have an access to the terrace, where you can enjoy unique views over the river and the park. There is also living area with 2 bedrooms with the separate entrance, that is not renovated. On the second floor, there are living premises for the manor lord - open living area with beautiful views to the park, kitchen, bedroom, sauna rooms and huge terrace with the river view. Also there are renovated guest rooms on the second floor, with its personal bathrooms. STABLE: On the plot, there is also 400 sq.m stable house, which is perfect for conferences, seminars, events. If wanted, it could be a place for exclusive spa or sauna complex. Kiviloo Manor is suitable for many purposes: it could be an exclusive private home/villa, boutique hotel/guesthouse, conference centre, spa-complex. Also it could be used for hunting tourism, also built as a private hospital/health club. For more information, please don't hesitate to contact me!
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Arco Vara AS and SIA Arco Real Estate (hereinafter "Company") management jointly announce management buyout (hereinafter "MBO") of the Company. On 31 October, ...
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On 14 October 2016, AS Harju Elekter signed a contract for the purchase of the real estate company Kiinteistö Oy Uutvallinkulma. Following the transaction, ...
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If you wish to let out or sell your apartment or find buyers for your private house, Baltic Sotheby`s International Realty will find appropriate tenants ...


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types of flow: laminar/turbulent
types of flow: laminar/turbulent. edexcel physics AS
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Types of flow...
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Laminar flow is a non turbulent
motion of a fluid in which
parallel layers have different
velocities relative to each other.
It occurs on stream lined
objects, low surface area.…read more
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Laminar flow:…read more
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Turbulent flow is where the
velocity at any point varies
erratically. It occurs mainly
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Can a vegetarian person get a good meal at this restaurant?
Can a gluten free person get a good meal at this restaurant?
Is this restaurant good for brunch?
Does this restaurant offer outdoor seating?
Does this restaurant offer highchairs for toddlers?
Is this restaurant good for dinner?
Is this restaurant good for lunch?
Does this restaurant offer takeout or food to go?
Is this restaurant good for breakfast?
Can a vegan person get a good meal at this restaurant?
Thanks for helping!
The menu offers traditional comfort food, burgers and a selection of beer. We shared a platter of "Blarney Chips" (nachos with wafer potatoes salsa and side of sour cream). Delicious - I loved them!
We went to this restaurant at around 3 PM on Saturday with my family and they were all disappointed with their meals. The hamburger meat was dry, the club sandwich had very little chicken (coming from my mom that doesn't eat a lot that says something). The extra gravy that was asked came cold and had to reorder. My uncles...
Get the bacon cheeseburger. I am dreaming about it. The lettuce is crunchy and their "max sauce" is to die for. They have crremore on tap,, nice. And our server was so nice!
Good atmosphere and table, but took 30-40 minutes for us to get our drinks and another 30-40 to get our food thereafter. When it did come, one order was missing and didn't follow for another 10-15 minutes--a long time for a side of fries. Also annoyed that I ordered a Steamwhistle, the advertised special, but instead of getting the advertised...
Want to feel like you are smack in the middle of this country? Then go have a beer at D'arcy McGee's!
First, it is not really in the Byward Market: not a huge walk from there, but it is on the Sparks Street Pedestrian Mall, not the market. But very close to the War Memorial and Parliament Hill.
Decent restaurant, part of the Fionn MacCool's chain,currently part of Cara foods. Nice atmosphere, friendly waiter, good beer and decent pub food for...
We went for an after noon snack with a beer.
Upon arrival we had to ask to sit because we were just standing with no one coming to see us. Afterward, the service was great and staff friendly though.
They have their beer of the day for only $4 which was great. We had the onion soup which was very...
Went early on a Saturday night and got sat in a uninspiring table where we couldn't see anything other than each other. The food was good but not incredible. Considering I had an Irish dinner I figured it would be better than it was. My friend said his burger was very good.
A standard chain restaurant. Our burgers were very good, the service was efficient but decidedly unfriendly. A little smile can make a difference.
We went early because we know they can get busy but we were still crammed downstairs at a high top table where we were bumped into all meal. The server was nice enough and quite helpful. The food was good but the coffee tasted like it had sat there for a while and the margaritas were made with some cheap...
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Town Square
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AROUND TOWNWednesday, March 7
[http://www.theatreworks.org/shows/1112-season/nowcircathen ==B Theater:== 'Now Circa Then'] TheatreWorks' new comedy play,...Original post made on Mar. 8, 2012
Last comment by randy albin, on Mar 8, 2012 at 12:41 pm | 1 comment | 2100 Views
AROUND TOWNFree tax help today at MV library
Free bilingual assistance with filing taxes is available today, March 7, from 2-7 p.m. at the Mountain View Library, 585...Original post made on Mar. 7, 2012
There are no comments yet. 2595 Views
AROUND TOWNArmed robbers take jewelry from shop
Two men robbed a Mountain View jewelry store at gunpoint in the morning, Feb. 28, police said. Read the full story here...Original post made on Mar. 1, 2012
Last comment by Spare the rod, spoil the child, on Mar 7, 2012 at 7:43 pm | 20 comments | 2757 Views
AROUND TOWNCouncil balks at $100,000 shuttle study
Would Mountain View residents really use a city-run shuttle service? On Tuesday evening, Mountain View City Council members...Original post made on Feb. 29, 2012
Last comment by gcoladon, on Mar 7, 2012 at 5:23 pm | 13 comments | 1284 Views
AROUND TOWNFeature story: A romance in black and white
Eighty-year-old Henry Ford sat in the dining room of his Palo Alto home and recalled the day he met Rochelle, his wife of...Original post made on Mar. 2, 2012
Last comment by allheritage, on Mar 7, 2012 at 2:11 pm | 10 comments | 2876 Views
OTHER ISSUESArrillaga plan could give TheatreWorks a permanent home
In its roughly four decades on the Peninsula, TheatreWorks has piled up raving reviews and theater awards, but one prize...Original post made on Mar. 6, 2012
Last comment by Liz, on Mar 6, 2012 at 3:41 pm | 2 comments | 3035 Views
AROUND TOWNOne household's eye-opening energy audit
A pair of detectives went to work in a Mountain View home this week, probing for the secrets behind its energy bill. The...Original post made on Mar. 1, 2012
Last comment by Dear Jack,, on Mar 6, 2012 at 1:22 pm | 7 comments | 24654 Views
OTHER ISSUESNew grocer seeks city's help
Anne Origel, co-owner of Ava's Downtown Market and Deli, asked the City Council on Tuesday for some financial help as the...Original post made on Feb. 24, 2012
Last comment by JUST THINK ABOUT IT, on Mar 6, 2012 at 12:54 pm | 44 comments | 7272 Views
BOOKSEarthquake, 4.0, rattles Bay Area Monday morning
A 4.0 magnitude earthquake centered in the East Bay shook the Bay Area early this morning, followed by a second magnitude...Original post made on Mar. 5, 2012
Last comment by Ross Finlayson, on Mar 6, 2012 at 1:41 am | 3 comments | 4778 Views
AROUND TOWNTaqueria La Bamba burglarized
Around $3,500 to $4,000 was stolen from Taqueria La Bamba in a burglary in the early hours of Feb. 28, police said. Read...Original post made on Mar. 1, 2012
Last comment by Observer, on Mar 5, 2012 at 2:52 pm | 19 comments | 4076 Views
OTHER ISSUESWhat will happen to N. Bayshore?
With the stroke of a pen, the City Council can create the opportunity to build a new downtown just north of Hwy. 101 to serve...Original post made on Mar. 5, 2012
Last comment by Chris Conroy, on Mar 5, 2012 at 8:47 am | 1 comment | 2587 Views
BOOKSClasses help parents help their kids
There are many ideas for ways to close the gap in achievement that exists between students from poor families and their better-off...Original post made on Mar. 5, 2012
Last comment by Aisha, on Mar 5, 2012 at 4:46 am | 1 comment | 4953 Views
SCHOOLS & KIDSDonate Used Musical Instruments
Is your child's old cello sitting in the corner, unused? Have your son outgrown your guitar? Is your daughter's recorder...Original post made by Ryan Young on Mar. 4, 2012
There are no comments yet. 2766 Views
AROUND TOWNMan killed on train tracks Feb. 23 is identified
A man who was fatally struck by a train in Palo Alto on Feb. 23 has been identified as Wentao He, 23, of Mountain View, the...Original post made on Mar. 4, 2012
Last comment by MeNewsman, on Mar 4, 2012 at 10:41 am | 1 comment | 2468 Views
OTHER ISSUESThe end of the drive-thru on El Camino?
Citing human health, climate change and neighbor concerns, the City Council took aim at the uniquely American creation known...Original post made on Feb. 22, 2012
Last comment by Ian, on Mar 4, 2012 at 7:12 am | 70 comments | 26412 Views
AROUND TOWNFire guts apartments on Dana Street
Firefighters battled a four-alarm structure fire in Mountain View Monday afternoon that damaged 26 apartments. Read...Original post made on Feb. 28, 2012
Last comment by NW Resident, on Mar 1, 2012 at 4:18 pm | 5 comments | 2923 Views
SPORTSNew exercise system 'hacks the brain'
Peter Wasowski wishes he was a kid again, but not for the reasons you might think. He doesn't yearn for the freedom of summer...Original post made on Mar. 1, 2012
Last comment by Member, on Mar 1, 2012 at 2:48 pm | 1 comment | 7543 Views
AROUND TOWNFire guts Dana Garden apartments
In only a couple of hours, about 50 people found themselves homeless following a four-alarm fire that engulfed the second...Original post made on Mar. 1, 2012
Last comment by margaret, on Mar 1, 2012 at 10:31 am | 1 comment | 2800 Views
OTHER ISSUESPolice ID man who died in car crash
Family and friends of Brian Drocco say that the Mountain View resident is the man who died in a fiery car crash in the early...Original post made on Feb. 24, 2012
Last comment by E, on Feb 29, 2012 at 11:39 pm | 14 comments | 5531 Views
SCHOOLS & KIDSAcademic Achievement
<B>AJ Tutoring, LLC Read the full story here http://www.mv-voice.com/story.php?story_id=7098 posted Friday, August 5, 2011,...Original post made on Feb. 29, 2012
Last comment by Observer, on Feb 29, 2012 at 9:21 pm | 2 comments | 2772 Views
Engagement Rings: Myths and Options
By Chandrama Anderson | 1 comment | 4,013 views
Opening alert: Go Fish Poke Bar in Redwood City
By Elena Kadvany | 2 comments | 3,076 views
It's President's Day. Why Not Butter Up the Boss?
By Laura Stec | 4 comments | 1,268 views


text: Lady Gaga's New Song Sounds Like It Should Only Be Played On HalloweenKate Dries8/12/13 3:45pmFiled to: lady gagaapplausesingleartpop1121EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Lady Gaga has leaked her new single "Applause" and though it is perhaps better than "Burqa", for a woman who has a notably fantastic voice, the faux-horror movie man voice she uses to sing most of the song is not particularly fun to listen to. "Applause" is basically Gaga's version of "My Prerogative", as she addresses how she likes attention in a sort of nonsensical I'm-famous manner. It makes those of us who loved "Just Dance" yearn for the days when she wasn't constantly putting out work that references her own celebrity. Gaga would like you to note that she is not singing "cunt", she is saying "Koons" as in Jeff Koons the pop art artist, an apparent tie to her album title ARTPOP. Image via TwitterReply112 repliesLeave a reply


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Hotfrog Philippines provides information regarding Kenny Rogers Roasters in Las Piñas Metro Manila. Kenny Rogers Roasters is located at SM Southmall, Las Piñas Metro Manila 1750 and provides Food And Dining services. Contact them by visiting them on their website http://www.kennys.com.ph/.
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Mon 11:00-14:00, 16:00-20:00; Tue 11:00-15:00, 17:00-20:00; Wed 11:00-12:00, 15:00-20:00; Thu 10:00-12:00; Fri 15:00-20:00; Sat 10:00-20:00; Sun 10:00-21:00
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Sant'Agata Bolognese, Italy
Posted 34 days ago
Electrical Design Responsible (Combat Spain)
Airbus Group
Getafe, Spain
Posted 34 days ago
Geotechnical Engineer
Deme Group
Breda, Netherlands
Posted 37 days ago
Mechanical Design Engineer
Da Vinci Engineering
Stuttgart, Germany
Posted 39 days ago
Structural Design Assistant
Warszaw, Poland
Posted 39 days ago. Deadline 31 March
Logistic Engineer
Automobili Lamborghini
Sant'Agata Bolognese, Italy
Posted 39 days ago
Electronic/Electrical Systems Design Engineer
Chess Dynamics
Plymouth, United Kingdom
Posted 40 days ago
Sales Representative - Nalco Water - North West
Cremona, Brescia or Milan, Italy
Posted 40 days ago
Cost Engineer
Århus, Denmark
Posted 41 days ago
Process Development Engineer
Lem, Denmark
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Warsaw, Poland
Posted 67 days ago. Deadline 30 March


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Summer skiing? Squaw Valley says it plans to stay open until...
Pfeiffer Canyon Bridge in Big Sur cracked beyond repair by...
Photos show the insane amounts of snow piled up in Tahoe
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Report: Man repeatedly disposing of body lice in UC Berkeley...
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Man kicked off flight to Houston after racist comments
Why Kellyanne Conway Hasn't Been on TV Lately
Anderson Reservoir spills over for first time in 11 years as...
100-foot tree falls on building in San Francisco
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Travel shows journey beyond the networks
Increasingly, fans of seeing other parts of the world through programs and short videos are looking for it online (especially as networks such as the Travel Channel have made nearly every show just 43 …
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Travel resolutions: Don't obsess over cost (No. 5)
(Editor's note: Just as we could all lose a little weight, spend less money or give up smoking, there are things that we as travelers could be doing better. Here's the sixth of our 10 Travel …
Travel resolutions: Write it down (No. 7)
(Editor's note: Just as we could all lose a little weight, spend less money or give up smoking, there are things that we as travelers could be doing better. Here's the fourth of our 10 Travel …
60-second tip: Don't be a toxic cloud
Sure, you don't want to stink while traveling in close quarters, but you don't want to be a toxic cloud either. Why are perfume and cologne a big issue for some travelers? (EDITOR'S NOTE: This weekly …
60-second tip: Help someone other than you
It's painfully easy to travel long distances like a zombie, without considering or helping anyone but yourself. Here's a challenge that we guarantee will make you a better traveler. (EDITOR'S NOTE: …
60-second tip: Travel with a "quest"
Sometimes there are so many ways to see a great place, you don't know where to start. Try searching for something other than the typical attractions. Give yourself a quest. (EDITOR'S NOTE: This weekly …
60-second tip: Prep phone for travel mishaps
You can print your itinerary or keep it on apps such as TripIt, but when seconds count (canceled flight, maybe?), prepping your phone before the trip can pay off. (Video shot track-side at the …
60-second tip: Check out room at check-in
It's easy to spread out and get comfortable when you first check in to a hotel room, but you'll want to first make sure the room is worth what you're paying — and if not, be prepared to ask for …
60-second tip: Avoiding battery meltdown
When you leave the batteries inside travel gadgets you only use a couple times a year, you run the risk of a battery meltdown. (EDITOR'S NOTE: As part of our ongoing attempts to ease the toils of …


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Track Listing: Caballero; Un Fingo Andalou; Libanera; Prelude To A Boy; Tamboura Rasa; Mmball; Osterled; Life So Far; Tribute; Mail Me Or Leave Me; Alle Bla De Er; Water Glass Rhapsody; A Surrender Triptych.
Personnel: Trygve Seim: tenor and soprano saxophones; �yvind Br�kke: trombone; Mats Eilertsen: double bass; Per Oddvar Johansen: drums.
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Scotty ATL x David Banner – Black Man (prod. by DJ Toomp) @ScottyATL
Posted in Uncategorized
Scotty ATL and David Banner team up for new collab, "Black Man", produced by DJ Toomp. This is like, a perfectly executed offering. First, we got Scotty, who's one of the most standout up and comers out of the south with a great message, then you have David Banner, who's always been a strong voice for our people. Lastly, they got legendary producer DJ Toomp to provide the beat, which is perfect. Isn't it always, though? Love this.


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This activity has GetYourGuide's stamp of approval! Exceptional customer service, knowledgeable staff, and a great time guaranteed.
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Cycle The Golden Gate Bridge and Alcatraz Ticket
Duration: 3 hours
From £94.15 per personBook now
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Product ID: 45451


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Library Branch
Call Number
Material Type
Home Location
|Bob Harkins Branch
|Adult General Collection
On Order
Scandinavians work less than we do, they have free childcare and healthcare, and they're just generally happier. We're told that we can't have what they have... but what if we can? In Viking Economics, George Lakey explains how the Nordic system works and shows us that if we put in the hard work Scandinavians did not that long ago, we, too, can have a fairer economic policy.
Author Notes
GEORGE LAKEY is Visiting Professor at Swarthmore College. He is the author of many books and articles and has written for Waging Nonviolence and Common Dreams, among other publications.
Reviews 1
Library Journal Review
Thinking of moving? Looking for a place with free education, health care, and job training? Forget Canada, try Norway! In this book, Lakey (Toward a Living Revolution) lays out the many benefits of the Nordic system. Although he is not actually trying to convince readers to move to Scandinavia, he does point out many advantages those countries have and the lessons that other nations can learn from their methods. Lakey relates policies in Norway, Sweden, Denmark, and Iceland to current events in the European Union (EU) and the United States. He points out that the Nordic reliance on co-ops, unionization, and social support programs has enabled those countries to bounce back faster from economic downturns. Throughout the text, nonviolent collective action is emphasized as the path to a better quality of life and high levels of equality and happiness. Norway and Iceland are not part of the EU (unlike Sweden and Denmark), but they are part of the European Economic Area. Norway has a particularly close relationship with Europe and admits many refugees and guest workers. Verdict Norway may serve as a model for the post-Brexit UK, and readers with an interest in how the Nordic model came about will be fascinated by this timely title.-Cate Hirschbiel, Emerson Coll. Lib., Boston © Copyright 2016. Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.
Table of Contents
|Introduction: Discovering Today's Vikings Beyond the Guidebooks
|p. vii
|Part I How They Got to the Top
|1 Vikings as Iconic Adventurers, Then and Now
|p. 3
|2 Making Their Way in a Globalized World
|p. 11
|3 Vikings Get Lost, Bankers Go Wild
|p. 27
|4 Iceland Creates the Biggest Crash, then Rebounds
|p. 35
|5 How Norwegians Empowered Themselves to Adopt the Nordic Model
|p. 53
|Part II Design for Living in the Nordic Countries
|6 More Start-ups than the United States: Support for Entrepreneurs, Workers, and the Equality of Women
|p. 75
|7 Family Farmers and Cooperatives: Key Players in the Nordic Model
|p. 95
|8 Preventing Poverty: Nordics Learn How an Advanced Economy Can Abolish Poverty
|p. 105
|9 Creating Work/Life Balance
|p. 131
|10 Breaking Barriers to Education and Lifelong Learning
|p. 143
|11 Paying for What You Get: The Viking Approach to Taxes
|p. 161
|Part III Today's Challenges, for Them and For Us
|12 Allowing Racial and Other Differences to Work for the Common Good
|p. 179
|13 Reaching for High Goals on Climate Change
|p. 205
|14 How Relevant Is the Nordic Model to the United States?
|p. 221
|p. 249
|p. 251


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- Reviews
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There is a lot of information out there regarding Tecademics mobile marketing. If you want to use it to your advantage, it is often difficult to weed through all the tips and advice available. This article will highlight some of the most important strategies to start with. From there, set up a plan, continue to do your research, and watch as you reap the rewards from your hard work.
Push messages can work to your advantage if you use chris record training properly. For example, once a customer has agreed to get updates from you, think about pushing them a deal or two in the form of a coupon code. This is a great way to utilizemobile marketing and it tends to make customers feel very positively about your Tecademics business.
Think about how many messages you want to send out to your customers. Be clear with them what they can expect to receive. Stick to your plan so that your customers know how your business operates. They may even look forward to your messages!
The mobile version of your chris record training website is likely not as clean or as functional as your desktop version. If you want customers to purchase from you, you should give them a direct link to anything of importance. For example, if there is a sale going on, provide that link. Customers can navigate right to the page in question. If you make it easy for them, they are more likely to spend time on your site.
You want to stay in contact with your customers in some way. It helps the mobile marketing process. Make sure they know how to get in touch with you. For example, provide your email. Set up a forum. Respond to Facebook inquiries. Multiple forms of communication is always a good idea.
Once you get your chris record training tecademics campaign rolling, have other people check out your website with their mobile phones. Ask them to click on links, watch videos and essentially act like a customer. They have the potential to provide great feedback to you regarding your campaign.
Think about when you want to send out messages. It is generally a good idea to avoid doing so at odd hours, like in the middle of the night or on Sundays. You may not know what time zone all your customers are in, so just use your own time as a guideline. It should be working hours when you send the messages, and if you do it around lunch, you should be okay.
Data is important. It lets you know how your mobile campaign is doing and helps you figure out what you need to tweak or keep the same going forward. To that end, the software that you use for data collection needs to be made for Tecademics mobile devices. A few that you can try are Mobilytics and Bango.
Your mobile marketing campaign will have its ups and downs. If you are going through a tricky period, simply try to get through it. Don't make huge changes, because you might regret them later. Continue to work hard and things should change for the better shortly.
As technology and the world change, so will your customers. Therefore, you have to be willing to adjust your mobile marketing strategy as necessary. Make sure you know what is happening currently and try to keep up so that you stay relevant.
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There is a lot to learn with respect to mobile marketing. Most of that information is available to you, if you take the time to look and to research. The information provided here is a great way to get started. Dive in headfirst to this exciting world and see what it can do for your business!


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London's Changing Riverscape: Panoramas from London Bridge to GreenwichBy: Mike Seaborne (author), Graham Diprose (author), Craig Charles (author)Hardback
More than 4 weeks availability
DescriptionThis remarkable book presents a modern photographic panorama of the River Thames by Charles Craig, Graham Diprose and Mike Seaborne, alongside one created by the Port of London Authority in 1937. Thames Panorama is a fascinating study of how the twentieth century has changed the face of the Thames. First published in 1988 and updated for the Millennium, this book is again being brought up to date, a sign of how rapid the pace of change has been for London's river. And yet amid the sparkling new developments and brash architectural statements that have sprung up, a sense of continuity is apparent when the two panoramas, albeit separated by more than seventy years, are shown side by side.
Create a review
About AuthorGraham Diprose is Lead Tutor in Photography in the School of Graphic Design, at the London College of Communication, the largest college in The University of the Arts, London. Having spent many years as an advertising photographer, he now works with undergraduate and postgraduate students developing skills in all areas of applied and experimental digital and craft photography. Always interested in digital photography, Graham's first capture was in eight black and white tones on a BBC Micro in 1984! A more recent picture at 248 million pixel of Gas Street Basin, Birmingham was until recently, the largest digital photograph in the world shot from a single lens position. Graham has been a Co-partner in Londons Found Riverscape since its inception and was involved in making the 1997 panorama, exhibitions at City Hall and Museum of London and the publication of London's Riverscape - Lost and Found . Over the past decade he has also worked with digital photographer, Jeff Robins to produce a series of over 60 past and present images of the River Thames for their project "...in the footsteps of Henry Taunt" The hardback book of the project "River Thames Revisited" was published in October 2007 by Frances Lincoln and has accompanied an national exhibition with English Heritage as a co-partner which was also launched in October 2004 at River & Rowing Museum, Henley and will tour for some years to come. Jeff Robins and Graham have also been invited to write a new text-book of photography for Thames and Hudson, to be published in the UK and USA in 2011. Born in London, Charles Craig trained as a commercial photographer at The London School of Printing and Graphic Arts. He entered the world of professional photography in the early 1960s, and the world of academia in the mid 1970s. Charles Craig died in 2011. Mike Seaborne is both a photographer and Senior Curator of Photographs at the Museum of London. He lectures and writes on photography and in 1995 he curated the landmark exhibition, 'Photographer's London, 1839-1994' and wrote the accompanying book. His own images have been widely exhibited and published. Mike's photography is primarily concerned with exploring the urban landscape. In the early 1980s he focused on London's Docklands because it was clear that this area was about to undergo a major transformation. The resulting pictures evoke a lost landscape which is in stark contrast to the thriving Docklands of today. From the 1990s Mike broadened his range of subject-matter but developed a particular interest in the landscapes created by the various social housing schemes in London from the late 19th century to the present day. Most recently he has been photographing in the Lower lea Valley, site of the London Olympics in 2012, and other areas in transition, especially in the inner-city, where rapid change is occuring as a result of social/cultural forces such as gentrification and ethnic concentration.
Product Details
- publication date: 02/03/2009
- Format: Hardback
- Number Of Pages: 240
- weight: 1406
Delivery Information
- Saver Delivery: Yes
- 1st Class Delivery: Yes
- Courier Delivery: Yes
- Store Delivery: Yes


text:
[ est. 4 21 1999 ]
Share this Site
Aftermath - 2000
One year later...
Robyn Anderson
told the House Judiciary Committee in January 2000 that a background check would've intimidated her sufficiently to keep her from buying the weapons. (
Read her
full statement
Beth Nimmo
, mother of victim
Rachel Scott
, complained to the press about the release for public sale of the Jefferson County Fire Deparment's footage of 4-20, a 'training video' that originally featured
music used without permission
January 12, 2000
-- Jefferson County Sheriff John Stone was issued a temporary restraining order against his releasing a videotape made by Eric Harris.
January 20, 2000
-- Jefferson County school board voted 4-1 to support a plan to demolish the old library at Columbine and build an atrium in its place. The vote included plans to build a new library. Philip Duran pleaded not guilty to the charges against him.
Lance Kirklin
continues to hunt with his dad despite the tragedy. He was shot four times by Harris and a fifth time at short range by Klebold, the shot that shattered his jaw.
Mark Taylor
attends a press conference with dad (Donnie) and mom.
January 21, 2000
-- Sharon Magness pledged $250,000 to build Columbine a new library.
January 27, 2000
-- 9 bills passed in the Colorado House Judiciary Committee, making for tougher gun-buying regulations in Colorado. Robyn Anderson, who legally bought three of the four guns used during the massacre of April 20th, spoke on behalf of the bills.
January 31, 2000
-- The family of
Isaiah Shoels
moved to Houston, Texas.
February 9, 2000
-- Michael Ian Campbell pleaded guilty to communicating a threat across state lines. Sentencing was set for April 28, 2000.
February 13, 2000
-- Nicholas Kunselman, 15, and Stephanie Hart, 16, - both students at Columbine - were killed late Sunday night at a Subway restaurant two blocks south of Columbine High School. Nicholas was supposed to lock up the store; Stephanie was there to give him a ride home.
February 14, 2000
-- The bodies of Nicholas Kunselman and Stephanie Hart were discovered at the Subway restaurant around 1:30 AM (Valentine's Day) by another Subway employee who noticed the lights were still on when she drove by. Victim
Rachel Scott
worked at the shop before she was killed at the school.
Later that same day, the ESPY Awards presented the family of
William "Dave" Sanders
the Arthur Ashe Courage and Humanitarian Award in Las Vegas, Nevada.
Tom Mauser gives an emotional speech at a rally protesting an NRA convention that was to be held soon
after the
Buell Elementary School shooting
, this time a fatality involving kindergartners.
February 19, 2000
-- A joint funeral service was held for Nicholas and Stephanie. The were buried alongside each other.
March 3, 2000
-- Jefferson County Assistant Attorney Bill Tuthill announced that the sheriff's office wouldn't make public any videotapes, diaries, or lists that were made by the gunmen until litigation concluded.
March 11, 2000
-- A new staircase was built outside Columbine High School by stonemasons.
March 12, 2000
-- Dawn Anna, mother of
Lauren Townsend
, was given the Sportswomen of Colorado's award for courage and inspiration.
March 27, 2000
-- Jefferson County Undersheriff John Dunaway announced that the official report from the sheriff's office would be released in May.
March 30, 2000
-- Bruce Springsteen donates 50 seats at his concert as a fundraiser for HOPE, the organization raising money to replace the library at Columbine High.
Open letter from the parents of Eric Harris:
We continue to be profoundly saddened by the suffering of so many that has resulted from the acts of our son. We loved our son dearly, and search our souls daily for some glimmer of a reason why he would have done such a horrible thing. What he did was unforgivable and beyond our capacity to understand. The passage of time has yet to lessen the pain.
We are thankful to those who have kept us in their thoughts and prayers.
Wayne and Kathy Harris -- 4-15-2000
April 9, 2000
-- In an effort to keep the media away from the school during the upcoming one year 'anniversary', Columbine High School was opened up for tours.
April 10, 2000
-- The families of
Kelly Fleming
Daniel Rohrbough
demanded release of the Jefferson County sheriff's department investigative report on the shootings to determine if they would sue. By Colorado state law, lawsuits must be filed by the one year anniversary of the event.
April 12, 2000
-- President Clinton returned to Denver for a SAFE Colorado gun-control rally and a town hall meeting with NBC-TV anchor Tom Brokaw.
Open letter from the parents of Dylan Klebold:
Nearly a year has passed since tragedy changed the Columbine
community forever. A day that began innocently ended catastrophically.
The healing process has moved slowly as we all attempt to cope, not
only with our own despair, but also with the distractions and intrusions
that result from world attention.
There are no words to convey how sorry we are for the pain that has
been brought upon the community as a result of our son's actions.
The pain of others compounds our own as we struggle to live a life
without the son we cherished. In the reality of the Columbine tragedy
and its aftermath, we look with the rest of the world to understand
how such a thing could happen.
We are convinced that the only way to truly honor all of the victims of
this and other related tragedies is to move clearly and methodically
toward an understanding of why they occur, so that we may try to
prevent this kind of madness from ever happening again. It is our
intention to work for this end, believing that answers are probably
within reach, but that they will not be simple. We envision a time
when circumstances will allow us to join with those who share our
desire to understand. In the meantime, we again express our
profound condolences to those whose lives have been so tragically
altered. We look forward to a day when all of our pain is replaced
by peace and acceptance.
Finally, we wish to thank those who have sent their kind thoughts,
prayers and expressions of support to our family. We are constantly
surprised and heartened by the gestures of understanding and
compassion that have been extended to us. The support has been
both humbling and inspiring, and we are truly indebted to those who
have offered it.
The Klebold family -- 4-15-2000
April 15, 2000
-- Parents of both shooters issued public letters of apology (see boxes).
April 17, 2000
-- Colorado District Judge Brooke Jackson ruled that the families of Kelly Fleming and Daniel Rohrbough could view portions of the sheriff's report and tapes. They were not allowed make copies or discuss anything they saw with the public.
April 18, 2000
-- Judge Jackson included all the families of those affected by the shootings in his ruling. Isaiah Shoels's family became the first to sue Sheriff John Stone.
April 19, 2000
-- 14 other families filed lawsuits against the sheriff and other authorities.
April 20, 2000
-- Many of the families of Columbine students decided to leave town instead of facing the media that flocked back to Littleton in droves for the one year 'anniversary'. Half of the students showed up at Columbine for a private memorial assembly in the gym, while the parents gathered in the auditorium to reflect on the year. Governor Bill Owens led a state-wide moment of silence at 11:21 AM to honor the victims, the dead and the survivors. Columbine High School opened the library to parents (though not the students) to help them cope with the 'anniversary'. At 12:30 PM a public remembrance ceremony was held at Clement Park. The Columbine Rebels girl's soccer team defeated Chatfield 2-0 that day. A candlelight memorial vigil at Clement Park's amphitheater was held that evening.
April 24, 2000
-- Judge Jackson ordered the Jefferson County sheriff's office to release the Columbine High investigative report by May 15, 2000.
April 26, 2000
-- Copies of the tape that the families were allowed to see before they brought lawsuits against the Sheriff's office was released to the public and sold by JeffCo for $25.00. The tape included a 20-minute walk-through of Columbine High School the day after the massacre, complete with footage from blood-stained furniture in the library, with close-ups on some of the evidence cards that indicated where dead students's bodies were found. This footage was set to
by Littleton firefighter Chuck Burdick, on his own time with his own money. The songs included
I Will Remember You
by Sarah McLachlan,
Columbine, Friend of Mine
by the Cohen brothers, and
If It Were Up to Me
by Cheryl Wheeler. The tape also included nearly two hours of aerial footage shot on April 20, 1999 by a KCNC-News4 helicopter.
April 27, 2000
-- Lawyers representing Sarah McLachlan and Cheryl Wheeler and their labels slapped Jefferson County with a Cease and Desist order, to stop them selling the video with the unauthorized recordings of their songs. Jefferson County officials defended the release and said they would not remove the songs.
April 28, 2000
-- After being threatened with lawsuits by the labels of Sarah McLachlan and Cheryl Wheeler with legal action, Jefferson County officials removed the songs from the tape.
Michael Ian Campbell, the Florida youth who threatened Columbine student Erin Walton via internet chat on December 15, 1999, was sentenced to four months in prison.
May 1, 2000
-- Sales of the tape still went well, even without the songs. eBay, after removing previous auctions of the tapes containing the music, allowed auctions of tapes without the music to be sold. (As a side note, they no longer allow ANY kind of Columbine videos to be sold through them.) Tom and Sue Klebold, parents of Dylan, together with Wayne and Kathy Harris, parents of Eric, filed a motion to keep items seized from their home immediately following the massacre out of the hands of the public.
May 2, 2000
-- ABC News reported that they had a draft of the investigative report and how it detailed the events of April 20, 1999 minute by minute.
HOPE reached its goal of $3.1 million needed to replace the old library with a
two-story atrium
and build the school a
new library
elsewhere on the campus.
May 3, 2000
Corey DePooter
was made an honorary Marine during a memorial ceremony at his gravesite.
May 4, 2000
-- Greg Barnes, a Columbine High student in his Junior year and a basketball player for the school team,
committed suicide
by hanging himself two weeks after the first 'anniversary' of the shootings. He was in the school on April 20, 1999 and escaped without injury, though he saw
Coach Dave Sanders
die and victim
Matthew Kechter
was a close friend of his. His father found Greg's body in the garage at 12:15 PM with a CD repeating one song over and over:
Adam's Song
by Blink 182. He left no note but it is believed the suicide was prompted by a recent break-up with his girlfriend. His death left
his family
and fellow students at Columbine stunned.
Rachel Scott's
father Darrel and sister
Bethanee read the hundreds of Christmas
cards that arrived for their family and Rachel.
Darrell Scott leads a memorial service
for the victims of the shootings.
Daniel Mauser's family spends a somber
moment at his memorial on Christmas.


text:
Amitava Banerjee, HT, 31 Jul 2016, DARJEELING: Gorkha Janmukti Morcha president Bimal Gurung's threat to resurrect the Gorkhaland agitation is being seen as an attempt by him to plug the steady erosion of his support base. Opposition parties have been making steady inroads in Hills politics.
Gurung recently had given the call for a final battle for Gorkhaland asking people to make the supreme sacrifice for statehood. The GJM president had stated that he is ready to face bullets for the Gorkha community and Gorkhaland.
Political observers feel that Gurung is trying to boost the already sagging morale of his party with the call for an agitation. It is very important for Gurung to rejuvenate the GJM and check the steady advance of the TMC, GNLF and JAP before the municipal polls.
In the Hills where the demand of Gorkhaland occupies centre stage, the call for another agitation is more of a political compulsion for Gurung in order to keep his support base intact, feel political pundits. Off late the GJM and the frontal organisations have been witnessing mutiny in the rank and files. 62 teachers of its frontal organisation Janmukti Insecure Secondary Teachers' Organisation (JISTO) had broken away and floated the Hill Secondary Temporary Teachers' Organisation (HSTTO) in mid July.
Though HSTTO claims that it is an apolitical organisation, observers feel they enjoy the tacit support of the TMC. Recently 20 members from JISTO broke away and joined HSTTO in the Kalimpong subdivision.
"Many more from the JISSTO from Kurseong and Darjeeling are scheduled to join the HSTTO soon. We have requested chief minister Mamata Banerjee's intervention requesting her to regularise the adhoc teachers working in the schools under the GTA. However, we will fight for our members alone and not for JISTO as they have their own organization," said Roshan Chettri, convenor, HSTTO.
Trouble started brewing with the GJM unilaterally declaring the sudden dissolution of JISTO Movement Committee on July 8. No reasons were stated for the sudden dissolution. More than 500 adhoc teachers have been agitating for the past one year demanding immediate regularisation under the aegis of JISTO.
Though the GISTO is a frontal organisation of the GJM, a section had been blaming the lackadaisical attitude of the GJM led GTA for not doing enough to resolve this impasse. The dissolution of the movement committee finally led to the floating of HSTTO by dissident leaders and supporters.
Closer home on July 26, 70 GJM supporters from Gurung's own Tukvar GTA constituency crossed over to the TMC. Tukvar is considered a GJM bastion and Gurung resides in the area. The people crossing over declared that they had full faith in Mamata Banerjee's development agenda hence they had preferred to cross over. The TMC was quick to dub it, "winds of change blowing in the Hills."


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Meaning of "anything's possible" in the English Dictionary
(Definition of "anything's possible" from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press)
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- anyroad
- anything
- anything but idiom
- anything like idiom
- anything's possible idiom
- anytime
- anyway
- anyways
- anywhere
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to touch with your lips, especially as a greeting, or to press your mouth onto another person's mouth in a sexual way


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Property DetailsInvestor Alert!! Renovations have begun. Now it is up to you to finish them. Semi-detached property zoned CN. Property has large fenced yard. Renovations that have been completed are new roof, raised roof in kitchen area, new Bathroom/laundry room, new hot water heater, new plumbing, new gas lines. Home was converted to natural gas. Washer & gas dryer included. Large attic can be used for extra living space. Great opportunity to make instant equity. All offers considered! This property is being sold as is. No repairs will be made. Offers made should be without contingencies. Any inspections are for informational purposes only.
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Additional Property InformationThis single family listing located at 2036 Duncan Rd, Wilmington, DE boasts two bedrooms and one bathroom. The property is currently selling for $73,000.
This property is listed by Michelle E. Anderson of Long & Foster Real Estate Inc. based in Virginia.