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In the United States, Primary Open Angle Glaucoma (POAG) is the second leading cause of blindness due to death of retinal ganglion cells (RGC). Our long term goals are to identify disease genes and investigate their function in the pathogenesis of POAG. Many risk factors for POAG have been identified, including advanced age, thin cornea and elevated intraocular pressure (IOP). Elevated IOP is caused by increased resistance to outflow of aqueous humor (AH) through the trabecular meshwork. The mechanisms linking thin cornea to glaucoma are not fully known, but it may cause susceptibility to RGC death independent of IOP. Currently, the only modifiable risk factor is IOP, which can be lowered by drugs, laser or surgery. However, the relationship between IOP and RGC death is unclear since some patients with IOP in the normal range develop glaucomatous optic nerve damage while others with elevated IOP do not. Nonetheless, lowering IOP slows progression of the disease, even for patients with so-called normal tension glaucoma. During our previous funding period, we identified ADAMTS10 as the disease gene in a colony of dogs with inherited POAG. ADAMTS10 protein is involved in formation of microfibrils which are extracellular matrix structures primarily composed of fibrillin-1 polymers. In addition to providing stretchable support in tissues such as blood vessels and skin, microfibrils are the primary reservoir of transforming growth factor beta (TGFbeta). TGFbeta is elevated in plasma and TGFbeta signaling is hyper-activated in affected organs in diseases associated with microfibril defects, such as Marfan syndrome. Defective microfibrils could for the first time provide a mechanistic explanation for the well-established elevation of TGFbeta in the AH of human POAG patients, which is thought to contribute to glaucoma pathogenesis. Discovery of ADAMTS10 as a POAG gene led us to form the hypothesis to be tested in this proposal that microfibril defects cause glaucoma. Using two independent mouse lines with well-established microfibril deficiencies, we will: 1. Test the hypothesis that microfibril deficiencies affect AH dynamics, 2. Test the hypothesis that microfibri deficient mice are susceptible to RGC death at normal and elevated IOP and 3. Test efficacy in preventing or reversing glaucoma phenotypes of a drug that inhibits constitutive TGFbeta signaling and is effective in treating Marfan syndrome, a known microfibril deficiency. The anticipated significant accomplishments of this project are: 1. Test a fundamental hypothesis that microfibril deficiencies cause glaucoma. 2. Establish a new model of glaucoma independent of elevated IOP. 3. Investigate glaucomatous RGC pathology independent of elevated IOP. 4. Test therapeutic approach to treat glaucoma based on the microfibril hypothesis.
In this project, we will test the hypothesis that defects in microfibrillar structures in the eye cause glaucoma. We will also test the efficacy of a medication that is widely used and well tolerated by patients who suffer from other diseases in treating glaucoma. The success of this project will have direct and implementable impact on clinical treatment of glaucoma patients.
|Kuchtey, John; Kunkel, Jessica; Burgess, L Goodwin et al. (2014) Elevated transforming growth factor ?1 in plasma of primary open-angle glaucoma patients. Invest Ophthalmol Vis Sci 55:5291-7
|Kuchtey, John; Kuchtey, Rachel W (2014) The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure. J Ocul Pharmacol Ther 30:170-80
|Kuchtey, John; Chowdhury, Uttio Roy; Uptegraft, Colby C et al. (2013) A de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor. Eur J Med Genet 56:292-6
|Kuchtey, John; Kunkel, Jessica; Esson, Douglas et al. (2013) Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles. Invest Ophthalmol Vis Sci 54:1881-6
|Kuchtey, John; Olson, Lana M; Rinkoski, Tommy et al. (2011) Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet 7:e1001306

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Environmental Disasters, Natural Recovery and Human Responses
By (author) Roger del Moral Lawrence R. Walker
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Environmental Disasters, Natural Recovery and Human Responses by Roger del Moral
Book DescriptionNatural disasters destroy more property and kill more people with each passing year. Volcanic eruptions, earthquakes, hurricanes, tsunamis, floods, landslides, fires and other natural events are becoming more frequent and their consequences more devastating. Del Moral and Walker provide a comprehensive summary of the diverse ways in which natural disasters disrupt humanity and how humans cope. Burgeoning human numbers, shrinking resources and intensification of the consequences of natural disasters have produced a crisis of unparalleled proportions. Through this detailed study, the authors provide a template for improving restoration to show how relatively simple approaches can enhance both human well-being and that of the other species on the planet. This book will appeal to ecologists, land managers as well as anyone curious about the natural world and natural disasters.
Buy Environmental Disasters, Natural Recovery and Human Responses book by Roger del Moral from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780521677660
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Pages: 220
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Publish Date: 29-Mar-2007
Country of Publication: United Kingdom
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This 2003 book examines ecological recovery following natural and human-induced disturbances.
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Roger del Moral is Professor of Biology at the University of Washington. His research includes the mechanisms of vegetation response to disturbances caused by volcanoes, glaciers, grazing and urbanization. He has practised wetland restoration for over 20 years and has experience with dune and subalpine meadow restoration. He had studied volcanoes on four continents, including detailed studies of Mount St. Helens that started in 1980. Lawrence R. Walker is Professor of Biology at the University of Nevada Las Vegas. His research focuses on ecological plant succession and the theoretical and practical lessons for restoration. His research in succession and restoration has encompassed work on volcanoes, dunes, glacial moraines, floodplains, landslides, cliffs, hurricanes, reservoir drawdown zones, abandoned roads and mine tailings.
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SQL Server 2008: Deep Dive into Spatial Data
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Look at some interesting and unexpected aspects of spatial data, where intuitive expectations collide with the hard realities of geometry and computation. Explore problems such as the ambiguity in spatial constructs, the certainty and precision of spatial calculations, and how types interact with indexes. Beyond understanding, see a demonstration of techniques for dealing with these issues in SQL Server 2008 using both built-in spatial functionality and server extensions.
Isaac KunenIsaac Kunen is a senior program manager on the SQL Server engine programmability team. Isaac has recently been concentrating on spatial database support, in addition to working on the SQL Server type system, SQL CLR integration, and database extensibility. Prior to joining Microsoft in 2005, Isaac was a developer at BEA Systems.
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Syrians detained in St. Maarten, Honduras with fake passports
PHILIPSBURG, St. Maarten – Three Syrians traveling with fake Greek passports are being held in the Dutch Caribbean island of St. Maarten, authorities said, while officials in the Central American nation of Honduras reported detaining a Syrian and two Pakistanis traveling by bus Saturday.
The St. Maarten public prosecutor's office said that the three Syrians were detained Nov. 14 and that an investigation was still trying to determine their identities and how and where they obtained the fake documents. Officials said they did not believe the Syrians are tied to any terrorist groups and had not asked for asylum.
Honduran officials said a Syrian woman and two Pakistanis were detained after they crossed into the country by bus from Nicaragua.
Police spokesman Anibal Baca told The Associated Press that authorities were looking for any links between the trio and five Syrian men who were detained in Honduras' capital Tuesday for traveling with passports allegedly stolen in Greece. Four of those five apparently were students.
Immigration officials were investigating to determine the validity of the travel documents presented by the three people detained Saturday, and the prosecutor's office said Interpol had been asked for help in checking their identities.
Kathya Rodriguez, director of immigration in Costa Rica, said the five Syrians held in Honduras did not appear to have any terrorist links. She said they entered Honduras from Costa Rica, after stops in Lebanon, Turkey, Brazil and Argentina.
In St. Maarten, prosecutor spokesman Norman Serphos told the AP that the three men being held there had arrived on an Insel Air flight from Haiti. Officials said the Syrians had traveled from Europe to Brazil, then gone to the Dominican Republic and Haiti before entering St. Maarten. It was unclear where they were headed.
Prosecutors said they had shared the information with Interpol and other international law enforcement agencies, including U.S. authorities.
Also this week, officials in Costa Rica detained a Syrian woman for allegedly traveling with falsified papers.
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D-Mad – I love you so much
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This Track is just epic Trance on another level, the type of track that makes people cry at Armin's live sets and make them act like he's god (literally, have you seen his documentary?). Speaking of which, the track was just premiered live ASOT 604. I don't even feel like Armin would play this in the the USA, all the kids head's at ultra would explode because all they've ever listened to is Swedish House Mafia's "Don't You Worry Child" and decided to buy a ticket and fly down to Miami. It's almost unbelievable that a dude like D-Mad would have less than 3k facebook fans, he's got to be one of the best dance trance producers in the world
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Hotfrog Philippines provides information regarding Establishment in Taguig Metro Manila. Establishment is located at Unit A, The Fort Entertainment Complex, Bonificio Global City, Taguig Metro Manila 1634 and provides Food And Dining services. Contact them on (02) 844 6364 or by visiting them on their website http://www.establishment.com.ph/.
Opening hours
Mon 18:00-20:00; Tue 11:00-12:00, 19:00-22:00; Wed-Thu 18:00-23:59; Fri 00:00-1:00, 19:00-23:59; Sat 00:00-2:00, 19:00-23:59; Sun 00:00-2:00, 19:00-20:00
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so does anybody know what to do with this.
so when i shut my truck off the motor keeps running for about 2 seconds. its not like your typicall engine dieseling over, it runs fine revs fine with the key off in this short period of time, its more like the ignition switch is slow disconnecting or something, it doesn't seem to be timing so far, i'm hoping it might be a sticky switch, that would be nice, plan on putting in a tilt column. any help would be nice.
5 Answers
yea its a bad switch
i would defininately say its the switch
depending on what engine and carbeuretor are in it, some of the early to mid '80's chev trucks had an anti-dieseling solenoid in the factory quadrajet carb. i own an '85 chev 3/4 ton and have come across this problem.
like others have said it is the swich, but look at all wires going to the swich
that is what they call "run-on" u are having a vacuum problem within ur carbureator....start ur engine and spray carb cleaner all around it and u will find the leak...make sure all vacuum hoses and breather hoses are hooked up correctly
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text: Death in Canada Click to block a category:GamingPoliticsNewsComicsAnimeOther pontawesome next random Comment Top NextComment next Tags: eh maple syrup o f . . Resolved Question Show me another on niitl If you die in Canada do you die in real life? Reandom Dot T months no Fr Report Abuse Pars on Best Answer - Chosen by Voters It!! l " Their socialized medicine will have you sealed in a cocoon .?. . and stored away and guarded by rabid Moose until acme can be found foryour ailment. Danielle Source( s): Te arm Eh? T months ago F' Report Abuse 33% 2 Votes 9 people rated this as good ... +74 Views: 5801 Submitted: 08/13/2013 Facebook Twitter Google+ Tumblr Pinterest


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Is there a difference or are they the same thing?
Speculative loads may be employed on an architecture, like Itanium, which does not support out-of-order execution. Then, they often require special treatment, such as check loads to determine whether the data have changed. If you used the term with respect to loads occurring on a mis-predicted branch, there it is not a question of out-of-order, and there isn't so much difference between in-order and out-of-order architecture.
More in context of x86 hardware. Speculative implies thatthe program won't detect such activity. Out-of-ordercould be the reason for speculative loads or it maynot depending on what the x86 memory model actually it.Kind of a catch 22. You have to know what the x86memory model is in order to be able to know what thex86 programmer docs define the memory model as. So I'mtrying to figure out what the non-program detectablehardware implementation specifics are so I cansubtract them out. What's left will be the memorymodel.
So if speculative == out-of-order, then I can subtractthem out and what's left is a TSO memory model.
Found the documentation for the IA-32 memory model. It's inthe Itanium System Architecture manual.
2.1.2 Loads and StoresIn the Itanium architecture, a load instruction has either unordered or acquire semantics while astore instruction has either unordered or release semantics. By using acquire loads (ld.acq) andrelease stores (st.rel), the memory reference stream of an Itanium-based program can be made tooperate according to the IA-32 ordering model. The Itanium architecture uses this behavior toprovide IA-32 compatibility. That is, an Itanium acquire load is equivalent to an IA-32 load and anItanium release store is equivalent to an IA-32 store, from a memory ordering perspective.
So IA-32 loads are in order and any references in the IA-32 docsto "out-of-order" only applies non observable speculative loadswhich have nothing to do with the memory model for programmers.
Emulation of IA32 on Itanium is in-order, unlike running on a real IA32. In practice, we can't do IA32 emulation on IPF, except with the IA32EL application, so we don't have control over which instructions are used. I'm still not clear whether you are asking about emulation on IPF, or normal IA32 execution.
The problem is there is no clear definition of the IA-32memory model, and a lot of conflicting opinions of whatit really is, namely as to whether loads are in-order orare out-of-order (i.e. not in-order).
I guess since there is no way to know what the actualIA-32 memory model is, is to assume the weakest one,loads out-of-order, and use lots of LFENCE and MFENCEmemory barriers where needed by the weaker model.


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The Will Rogers Motion Picture Pioneers Foundation announced today that veteran Hollywood producer Kathleen Kennedy is the 2013 Pioneer of the Year honoree. The awards dinner will take place April 15-18 at CinemaCon in Las Vegas. Sally Field will be presenting the award to Kennedy and Joseph Gordon-Levitt, who will be receiving the Breakthrough Filmmaker of the Year award at CinemaCon, is hosting the ceremony. Others to be honored at CinemaCon are: Breakthrough Performer of the Year — Aubrey Plaza, Cinema Icon Award — Morgan Freeman, Male Star of Tomorrow — Armie Hammer, Female Star of Tomorrow — Hailee Steinfeld, Director of the Year — Justin Lin, Rising Star of 2013 — Asa Butterfield, Award of Excellence in Acting — Elizabeth Banks, Comedy Duo of the Year — Vince Vaughn and Owen Wilson, Lifetime Achievement Award — Harrison Ford, Male Star of the Year — Chris Pine, Female Star of the Year — Melissa McCarthy. An 8-time Academy Award nominee, Kennedy now leads Lucasfilm since 2012 and is currently VP of the Academy of Motion Pictures Arts and Sciences as well as on the Academy's Board of Governors. Prior to joining Lucasfilm, Kennedy headed The Kennedy/Marshall Company, which she founded in 1992 with director/producer Frank Marshall, and in 1982 Kennedy co-founded Amblin Entertainment with Marshall and Steven Spielberg. Kennedy has produced or executive produced over 60 films, which have received 132 Academy Award nominations and 25 Oscars.
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Dog Walkers in Hartland, WI
Book a dog walker to give your dog a 30-minute walk around your neighborhood.
dogs are my passion!
Pewaukee, WI, 53072
Dog Boarding, House Sitting, Drop-In Visits, Dog Walking
About: I have worked at a dog daycare for the last three and a half years. I am comfortable with every type of dog there could be from hyper to nervous to... (more)
Reliable pet sitter
hartland, WI, 53029
House Sitting, Drop-In Visits, Dog Walking
About: Hey there! I'm Mel, I have always been an animal lover. I've always had dogs, cats, rodents, birds, reptiles as well! I currently have a handfu... (more)
Peaceful village fence work at home
Elm Grove, WI, 53122
Dog Boarding, Doggy Day Care
"Pliny loved spending the day at Teena's house while I was at work! He is used to having me at home during the day, and likes humans more than animals, so I d... (more)"
Dog loving family!
Waukesha, WI, 53186
Dog Boarding, Drop-In Visits, Doggy Day Care, Dog Walking
About: I have been dog sitting with Rover since August of 2016. We are having so much fun so far! Our beloved family dog passed away about 4 years ago and... (more)
Loving, compassionate care
Mukwonago, WI, 53149
Dog Boarding, Doggy Day Care
"Suzanne was very attentive and caring. Eddie enjoyed his time there. She sent pictures and updates throughout the day. (more)"
I am compassionate and kind hearted
Waukesha, WI, 53186
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About: I have had dogs in my home since before I could remember and grew up loving, caring, walking and training them. I find a lot of happiness and joy w... (more)
Loving Care by Work-From-Homers
Brookfield, WI, 53005
Dog Boarding, Doggy Day Care
About: My husband and I work from home all day, and we'd love to have your dog join us for a visit either during your travels or simply during your long w... (more)
Lifetime dog lover
Wauwatosa, WI, 53222
House Sitting, Drop-In Visits, Doggy Day Care, Dog Walking
About: Thanks for taking a look at me for your dogsitting needs! I am an avid dog lover, finding time spent with dogs to be relaxing and fun. My family ow... (more)
A Stay-cation for your dog!
Sullivan, WI, 53178
Dog Boarding, Doggy Day Care
"Buddy had a good day at Anna's. She was flexible on drop off and pick up and easy to work with. Sent a few picture updates as well. Worked out well for a day... (more)"
Dogs want to stay with Dog Lovers!
Brookfield, WI, 53045
Doggy Day Care
About: I am a dog lover, but by being a true dog lover is like having kids, you love them, but know you cant give them everything they want. Your pups wil... (more)
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Rover also offers dog walking in:
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We know you can't always be there, and it's our goal is to connect you with sitters in your neighborhood who can help take care of your pet. With Rover, it's easy to find and book Hartland dog walkers who will give your dog the exercise they need. Book a 30-minute walk one day, once a week, or even every day. That way, you can take care of what you need to do and know your dog is getting the love they deserve. No matter how often you need a sitter or dog walker, we're here for you. We're proud to offer complimentary premium insurance with dog walking services booked through Rover. The next time you're looking for a dog walker in Hartland, WI, visit Rover to search for the perfect dog walker, set up a Meet & Greet, and book a walk anytime you need it. All you have to do after that is sit back and relax: your dog's in good hands.
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Blog, Blog post, Blogger, blogging, Honey, Honey bee, HOney medicinal values, Important of Honey, Last prophet of God, Medical treatment, Medicinal Plants, Medicine, Patient, Prophet, Prophet Muhammad (S), Prophetic medicine, The prophetic Medicine by Ibn Qay'em El-Jozeyah
Honey has tremendous medicinal value, because it washes away the harmful substances that might be collected in the veins and the intestines. In addition dissolves excess moisture, is beneficial as a drink and as an ointment, it is of great value for the elderly, and those suffering from phlegm and cold moods or condition (chills). Honey is nutritious, softens one's bowel movement and is a good preserving agent. In addition, honey reduces the bitter taste of other medicines, cleanses the liver and the chest, aids in producing urine, and dissolves the phlegm that is accompanied by coughing. When honey is consumed hot and mixed with rose oil, it cures animal bites and the effects of opium. Taking honey mixed with water helps against the bite of a rabid dog and the effects of eating poisonous mushrooms. If fresh meat is kept in honey, it preserves its freshness for three months. Likewise if aourds, cucumbers and eggplants are kept in honey, they too will be preserved.
Honey In addition whitens the teeth, preserves their health and the health of the gums, opens the orifice of the veins along with causing the flow of menstruation. Furthermore, licking honey on an empty stomach will hell 'the body get rid of mucus and phlegm. It cleanses the stomach and rids it of harmful substances or mixtures, heats the stomach mildly and opens up the pores. Honey has similar effects on the kidneys, the prostate and theliver. Furthermore,honey is the least harmful sweet substance for congesting the liver and kidneys.
Honey is In addition a food, a drink, a sweet, a remedy, a type of refreshment and an ointment, along with its numerous medicinal values. Therefore, there is no other substance that is more beneficial than honey or that even rivals its value. This is why the people of old relied on honey,for most of the books of old do not mention sugar, as this was discovered in modern times.
The prophetic Medicine by Ibn Qay'em El-Jozeyah explained well about various diseases and their medicines.


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Hotfrog NewZealand provides information regarding Bp in Wellington. Bp is located at Fanshawe Street, Wellington 1010 and provides Transportation services. Contact them on 03-338 6356 or by visiting them on their website http://www.ottawabuddhistsociety.com.
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122 Summerfield Drive,Waverly MN, 55390
4 beds , 2 Full baths
1,800 sq. ft
Status: Active
Berkshire Hathaway HomeServices Lovejoy Realty
(608) 781-1100
Last Updated: 2/26/2017 9:11 AM
Description for 122 Summerfield Drive Waverly, MN 55390
4 BR Split - 3 car garage - Bath Skylite - One and a half story entry with huge window - Jacuzzi Tub - Walk-in Closet - Large LL Family Room. 4th bedroom currently used as an office.
Listing Information
1,800 Sq. Ft. (approx)
City Water - Connected
City Sewer - Connected
School Information
Room Information
Lower Level
Informal Dining Room
Main Floor Full Bath, Full Basement
Interior Features
1,100 Sq. Ft. Above Ground ,700 Sq. Ft. Below Ground
Range, Microwave, Exhaust Fan/Hood, Dishwasher, Refrigerator, Washer, Dryer, Water Softener - Owned, Disposal
Central Air
Gas Heat, Forced Air
Full, Finished (Livable), Drain Tiled, Drainage System, Sump Pump, Daylight/Lookout Windows, Egress Windows, Concrete Block
Kitchen Window, Skylight, Washer/Dryer Hookup, Main Floor Bedroom
Exterior / Lot Features
3 Garage Spaces, Attached Garage, Driveway - Asphalt
Brick, Stone, Vinyl
Asphalt, Age 8 Years or Less
Storage Shed, Road Frontage- City. Irregular Lot
Financial Considerations
FHA, Conventional
Inside AccessTM
Current market conditions for 122 Summerfield Drive
Active Market Trends
Source:MLS DATA
Median list price$199,900
Days on market121
Properties for sale8
Sold Market Trends
Source:MLS DATA
Median sold price$183,950
Sales to list price10,006.0%
Properties sold12
Median sq ft price$142
Arrows indicate 90 day trend
Listing Price History for 122 Summerfield Drive
Waverly Real Estate
Waverly is located in Minnesota. Waverly, Minnesota 55390 has a population of 1,162.
The median household income in Waverly, Minnesota 55390 is $62,656. The median household income for the surrounding county is $70,930 compared to the national median of $53,046. The median age of people living in Waverly 55390 is 33.9 years.
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Swingline TOT Mini StaplerSpecialty Staplers
12 Sheet Capacity - Pink - View Complete Details
Product Number: SWI79174
In Stock - Hurry, only 261 left.
Estimated Delivery - 1 business day(s) - Tue 2/28 2 business days - Tue 2/28
Free Returns - Return this item free of charge. View Details.
Shipping - This item is eligible for Free Shipping on orders over $45
Note: Must buy in quantities of 36 starting at 36.
Estimated Delivery 10 business day(s) - Mon 3/13 - The products will be shipped directly from the Manufacturer and will require additional time for delivery. 10 business days - Mon 3/13 - The products will be shipped directly from the Manufacturer and will require additional time for delivery.
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Swingline TOT Mini Stapler - Big power in a miniature stapler—the Tot® delivers a respectable stapling capacity and uses standard-sized staples. Everything you need for stapling on the go, this mini stapler features a built-in staple remover and a staple-storage compartment. Pre-packed with 1,000 staples, this stapler's great for work, home, school and travel. Durable high-impact plastic construction can withstand plenty of wear and tear and still provide quality stapling performance.
- Mini stapler uses standard-size staples.
- 12-sheet stapling capacity.
- Durable high-impact plastic construction will not break easily.
- Staple remover and spare staple storage compartment are built in.
- Pre-packed with 1000 staples.
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I held out from poas the last two cycles and just waiting till the blood test (I'm with an FS and using letrozole to prompt myself to O) but this cycle I've been a demon trying waaaaaay too early, so making myself broke!
How cheap is cheap?
I paid $6 for ten preg tests and 20 ovulation tests. Free shipping!
I've had symptoms in my head lol. I will be 8dpo on Saturday so may start with the Internet cheapies then haha
I spent $15 for 50 opks + 10 hpts
I don't need OPKs, as AF only visits every 3-4 months and therefore tend to ovulate sporadically... if I do at all!
I'd love to get some HPTs that don't cost $10ea! I'm definitely jumping online next cycle! Thanks, ladies!
Well I've day slept for past three days and I never do that. And am totally lethargic. Symptom spotting like mad lol. Roll on starting to POAS from saturday
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Performance Management:
Aligning Employee Performance With Agency Goals at Six Results Act Pilots
GGD-98-162: Published: Sep 4, 1998. Publicly Released: Sep 4, 1998.
Additional Materials:
- Full Report:
(202) 512-2637
Office of Public Affairs
(202) 512-4800
Pursuant to a congressional request, GAO reviewed selected Government Performance and Results Act pilot projects, focusing on the: (1) primary approaches taken by selected pilot projects to align employee performance management with organizational missions and goals; and (2) issues or challenges, if any, that these pilot projects commonly confronted while developing and implementing these approaches.
GAO noted that: (1) although all six pilot projects GAO reviewed included specific efforts to align their employee performance management systems with organizational missions and goals, their approaches varied in significant ways; (2) one way was in the kinds or groups of employees on whom they focused; (3) four of the pilot projects focused on managers rather than on staff at other levels; (4) the projects also varied in the extent to which organizational goals were explicitly reflected in employees' performance plans, and in whether they emphasized creating accountability for results at the individual or team level; (5) the two other pilot projects focused their approaches on essentially all employees, relying on total quality management principles as a guide and organizing employees into self-directed work teams; (6) none of the six pilot projects GAO reviewed reported having formally evaluated its employee performance management approach, but all reported possible benefits; (7) the six pilot projects faced several common issues or challenges; (8) the first of these involved identifying the flexibilities available to them--including human resource management (HRM) waivers and demonstration project authority--to tailor their HRM systems to their organizational missions and goals and other organizational circumstances or needs; (9) the second issue or challenge GAO identified involved the six pilot projects' efforts to include in their performance management approaches appropriate and meaningful goals and performance measures; (10) third, as the pilot projects worked to become more performance-based, each was confronted with the need to redirect its organizational culture toward a new understanding of the organization's mission or way of doing business and to secure the buy-in of employees; (11) the fourth issue GAO identified involved unintended consequences that pilot project officials said they confronted in implementing their new approaches, some finding that employees might try to game the system--that is, manipulate the performance measures to make their performance look better than it might actually have been--or might perceive a lack of fairness in the approach's implementation; and (12) officials at the six pilot agencies were aware of their employees' concerns and reported steps they had taken to keep abreast of the views of the managers and other employees who were the focus of the agencies' performance management efforts.
Feb 15, 2017
High-Risk Series:Progress on Many High-Risk Areas, While Substantial Efforts Needed on OthersGAO-17-317: Published: Feb 15, 2017. Publicly Released: Feb 15, 2017.
High-Risk Series:Progress on Many High-Risk Areas, While Substantial Efforts Needed on OthersGAO-17-407T: Published: Feb 15, 2017. Publicly Released: Feb 15, 2017.
High-Risk Series:Progress on Many High-Risk Areas, While Substantial Efforts Needed on OthersGAO-17-375T: Published: Feb 15, 2017. Publicly Released: Feb 15, 2017.
Feb 14, 2017
Government Purchase Cards:Little Evidence of Potential Fraud Found in Small Purchases, but Documentation Issues ExistGAO-17-276: Published: Feb 14, 2017. Publicly Released: Feb 14, 2017.
Feb 7, 2017
U.S. Postal Service:Key Considerations for Restoring Fiscal SustainabilityGAO-17-404T: Published: Feb 7, 2017. Publicly Released: Feb 7, 2017.
Jan 30, 2017
Federal Real Property:GSA Should Inform Tenant Agencies When Leasing High-Security Space from Foreign OwnersGAO-17-195: Published: Jan 3, 2017. Publicly Released: Jan 30, 2017.
Jan 26, 2017
2020 CENSUS:Additional Actions Could Strengthen Field Data Collection EffortsGAO-17-191: Published: Jan 26, 2017. Publicly Released: Jan 26, 2017.
Jan 6, 2017
FDA Facilities:Planning Efforts for White Oak Campus Should Further Incorporate Leading Practices to Address Ongoing ChallengesGAO-17-87: Published: Dec 7, 2016. Publicly Released: Jan 6, 2017.
Dec 8, 2016
Federal Building Management:Building Disposal Authorities Provide Varying Degrees of Flexibility and Opportunities for UseGAO-17-123: Published: Dec 8, 2016. Publicly Released: Dec 8, 2016.
Dec 2, 2016
American Samoa:Alternatives for Raising Minimum Wages to Keep Pace with the Cost of Living and Reach the Federal LevelGAO-17-83: Published: Dec 2, 2016. Publicly Released: Dec 2, 2016.
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The company is a molecule drug discovery and development company. The focus is on emerging epigenetic cancer targets. They are focused on emerging targets where they can be first in class. The company has a strong team of experts in epigenetics biology.
Financials (USD)
Asking Price Available On Request
Sales Available On Request
Profit Available On Request
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BREAKING NEWS 27.October.2016
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Exit Spa: sauna, beauty treatments and cosmetic medicine
Just outside Milan, today the oasis of relax and wellness Exit Spa has a new special division dedicated to cosmetic medicine treatments
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Ray Davies
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Raymond Douglas Davies, 21 June 1944, Muswell Hill, London, England. The cornerstone of the Kinks, Ray Davies is one of his countrys great songwriters. A peculiarly English architect of lyrics, Davies, an introverted seventh child, once stated an intention to write for waitresses and divorced people. However, over four decades he has provided a feast for allcomers, regardless of social station, from the simple urgency of You Really Got Me to the detached melancholy of Come Dancing. Often branded Englands kitchen sink lyricist for his depictions of British morality and normality, he has conversely flirted with the fringes of gay and transvestite culture in songs ranging from See My Friend to Lola and David Watts. Another thematic pivot is his feel for isolation. This was most ambitiously realized with Arthur (Or The Decline And Fall Of The British Empire), a set of songs...
- MatchRay Davies
- 100%The Kinks
- 94%Dave Davies
- 85%Pete Townshend
- 74%Badfinger
- 57%Ian Hunter
- 48%Al Stewart
- 48%Brian Wilson
- 48%The Who
- 46%Paul & Linda McCartney
- 46%Paul McCartney


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During replication of a DNA molecule, replication of the leading strand proceeds toward the replication fork, while the lagging strand is made in fragments in the opposite direction.
This difference in the synthesis of the two strands is the result of which of the following?
Select ALL that apply.


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Dukakis Does A Little Better In 2 New Polls
By MICHAEL ORESKES
Published: October 20, 1988
Two surveys released yesterday paint a somewhat better view of the Presidential race for Gov. Michael S. Dukakis than was presented in a poll earlier this week, which showed an overwhelming lead for Vice President Bush.
Both of the new polls, by ABC News with The Washington Post and by Louis Harris & Associates, showed Mr. Dukakis trailing Mr. Bush, but not by the huge margin found in an NBC News/ Wall Street Journal poll Monday.
Despite the widespread view that Mr. Bush bested Mr. Dukakis in last Thursday's debate, the ABC/Post poll found essentially no drift to the Republican nominee after the debate. The Harris poll did find some strengthening of Bush support, compared with a poll earlier this month.
The ABC News/Washington Post poll, conducted Oct. 12 through Tuesday night, found Mr. Bush ahead by 52 percent to 45 percent among 1,196 likely voters. That was essentially unchanged from a poll released last week. The margin of sampling error was between three and four percentage points in either direction.
The Harris poll found Mr. Bush leading Mr. Dukakis by 53 percent to 44 percent among 1,356 likely voters who were surveyed after the debate, from Friday through Monday. In a Harris poll conducted Oct. 6-10, Mr.Bush led Mr. Dukakis by 50 to 48 percent. The margin of sampling error for both Harris polls was plus or minus three percentage points.
The NBC/Journal poll reported on Monday showed a 17-point lead for Mr. Bush, and Dukakis and aides clearly felt better about the surveys issued yesterday. ''The polls show what we've always said: the race is very competitive,'' said Leslie Dach, Mr. Dukakis's communcations director.
Poll comparing Dukakis & Bentsen, and Bush & Quayle


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text: Get on the Hydro Bus: Ford Introduces Hydrogen-Fueled V10Mike Spinelli7/18/06 9:30amFiled to: Alternative EnergyBusHydrogenE-450Ford3EditPromoteShare to KinjaToggle Conversation toolsGo to permalink This image was lost some time after publication. This image was lost some time after publication. Hide your copy of Led Zeppelin I: Ford's become the first automaker in the world (read: F-U, BMW) to put a hydrogen-fueled internal combustion engine into production. According to a release, the company's made good on its threats to build an airport shuttle that runs on hydrogen. The E-450 buses will be powered by the product of Ford's labors in this regard, a supercharged, intercooled 6.8-liter V10 engine that burns hydrogen in a manner similar to that of gasoline, only with near zero emissions of regulated pollutants and greenhouse gases. They've beaten the only other carmaker to say they'd bring a hydrogen-fueled ICE to market, BMW, which indicated earlier this year that their own hydrogen-fueled entry was two-years off. Their corporate buddy, Mazda has already started leasing dual-fuel (gasoline-hydrogen) RX-8s in Japan. Related: Mazda Starts Leasing Hydrogen Dual-Fuel RX-8s in Japan; Ford to Produce Hydrogen-Powered Airport Shuttle [internal] Reply3 repliesLeave a reply


text: Hey i just read the post where one person was talking about the DR leaf and lawn vac and was impressed. I was just wondering has anyone else had any experience with this machine? Is it commercial grade or would it be more suited to a home owner to use it a couple times a year? I am just optimistic about alot of machines that claim to have lots of power and be commercial grade if my dealer doesnt carry them and i cant look them over. Just looking for opinions


text: Hotel Mario 59,913pages on this wiki Add New Page Edit History Talk0 Share 1994 Retrieved from "http://logos.wikia.com/wiki/Hotel_Mario?oldid=803158" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Mario 1994 Nintendo Video games released in 1994


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As a manager or human resource administrator, it is your responsibility to deal with a rude employee. This is a challenging but necessary task. A rude employee can be detrimental to any business operation, causing decreased work production from co-workers and a loss of customers. It is imperative to address the situation and explain the behaviour that is expected from the employee within the workplace.
- Skill level:
- Moderately Challenging
Other People Are Reading
- 1
Document all instances of rudeness and unacceptable behaviour displayed by the employee. Documentation could include formal customer complaints, fellow employee complaints describing specific instances of rudeness and e-mails received from the employee containing rude language.
- 2
Speak with the employee in private. Remain professional during your meeting. Do not speak in an accusing or superior tone. Present the incidents of rudeness and how they are affecting your business operations. There is typically some underlying cause to the employee's behaviour. Determine if the employee is unsatisfied with a workplace situation, ill, dealing with personal problems or may have a drug or alcohol problem.
- 3
Offer help to find a resolution to the problem. Resolving the underlying problem may enable the employee to change their attitude in the workplace. The employee may need time off to deal with an ageing parent or an illness, rehabilitation for an addiction, anger management classes or counselling.
- 4
Enforce disciplinary action. If all other attempts to resolve the employee's rudeness to coworkers and customers have failed, disciplinary action may need to be implemented. Abide by your company's employee policies and procedures.
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Positioned in its own private plot, with a little garden at the front as well as a verandah with a view at the back, the Mountain View Courtyard is your perfect settlement. Wooden or stone-tiled floors, wood-beamed ceilings, large glass french windows, a large, luxuriously appointed bathing area - and the softest of beds to sink into after a trek in the jungles around.
The corner courtyards boast an extra living room along with a bedroom, a garden and a verandah. This living room attached to the bedroom, has floor to ceiling glass windows, and it is not uncommon to find deer on the other side, peering up at you.
A quaint log hut raised on stilts and fully wood-panelled inside, this is a memory to cherish a long time after your holiday is over. In addition to the usual amenities like a cosy bedroom and large bathing areas, the Mountain View Log Hut also has a well-stocked Mini Bar. Its very own back verandah is wood-beamed and perfect to sit out at and look at the blue hills beyond the dense forests and for the various birds that drop by.
Tastefully appointed and carefully designed, it is just the right mix of privacy and pleasure. The Residence has a vast living room cum bedroom, with separate bathing and dressing areas and an additional outdoor bathing area. You can find a quiet sit-out at the back and a flight of stairs at the front which leads you to a terrace with a sensational view of the forest and hills, and even a massive day-bed to sink into.


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Taken by the Cowboy : A Time Travel Romance
- $14.99
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New & Used Marketplace 11 copies from $8.99
More About Taken by the Cowboy by Julianne MacLean
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other than one of those mesh shoe holders which I have tried. And Im not a shoe box fan either living in an old 1940s home space is limited--open to ideas from anyone!
One of my friends uses one of the rolling rectangular plastic storage bins to store her shoes under the bed.
How many shoes do you have? I had redone my hubster and mine bedroom, and I use my old dresser to hold my shoes. We got rid of the dresser that was big and useless and started using plastic bins instead so I had my grandmother's dresser available. Have you thought of building like a tower of shelves in a corner to stack/place your shoes?
I met a girl who had hide away bed and instead of extra mattress she used for her shoes!


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11 Teacher-Approved Crafts for School
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"The Hushabye Shell Afghan is a beautiful blanket that would be a great shower gift. The pattern is an easy shell stitch and the colts are great for a boy or girl. I am sure that it will keep baby nice and warm. It is made with a nice four ply yarn and should work up fast. This one to save for a later date."
"The wavy rainbow baby blanket is one of the cutest that I have seen. The colors are so bright that a baby will enjoy looking at it. The blanket could also be worked up in other colors that would be great for that special little one. this is not for a beginner, so if this is your first try at crocheting you may not want to try it. Looking forward to working on this."
"The Springtime Lace Afghan Pattern is so cute. It will make a great baby blanket for that special baby. This could be made in many different colors that will really be pretty. The pattern reads really easy and a beginner could do this.I am looking forward to to this project in the very near future."
"he Cape Cod Afghan is really a cute pattern. It would be a great one for beginners. The pattern only calls for two skeins of yarn. The pattern reads really easy. This could also be used as a baby blanket and would look great in one of those baby colors. This is one pattern that I will definitely save for a later project down the road."
Denim Back-to-School Chalkboard
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This Denim Back-To-School Chalkboard from Amanda Formaro is a great way to use up those school clothes from last year that have gotten too small. Made with old jeans, this fun mosaic framed chalkboard is great for decorating lockers, classroom doors, or using as a drawing pad for math lessons.
You could make this fun back-to-school craft with your son or daughter to give to their favorite teacher during Teacher Appreciation Week. Teachers could also use these cute DIY projects to hang outside their classrooms and leave messages for their students when they're out of the room.
For more fun school projects, check out
these adorable 33 Back-to-School Crafts.
- Framed chalkboard
- Recycled denim jeans
- Scissors
- Hot glue gun
- Dye or acrylic paint (optional)
Note: The project pictures uses a few splashes of color by using recycled dyed jeans. You can dye some if you like or use acrylic paint to color some pieces. No fabric medium is needed as you won't be running these jeans through the washer!
- Cut denim into squares wide enough to cover and overlap the border of the chalkboard.
- Hot glue the squares all the way around the border, overlapping a little as you go and alternating different shades and types of denim for some contrast.
- Cut colored denim into smaller squares and glue then randomly around the frame.
If you enjoyed this denim project, check out our other ideas about
What To Do With Old Jeans: 29 Recycled Crafts With Denim.
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Jul 11, 2013
This is cute. I save jeans for rag rug backs, so I have plenty! As kids' SS teacher, I'm wondering if they can't put their scripture on it for the week. Thanks again.
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Comment Re:where.. (Score 1) 159
*Where has
*Where has
Or just use a USB-A to USB-C cable? Like I do with my Nexus 5x. Hilarious.
The majority of my downloading has been public trackers in the past 2 years. Got bored of the ratio upkeep on private trackers so switched to newsgroups. Just use torrents when the nzbs fail.
I checked mine, from my own IP that I do all my torrenting from. It came up blank.
Hairnett BBS, was all I used it for!
Anyone want to crowd fund a class action lawsuit?
chatting on my Amazon cell phone.
Never thought I'd encounter someone that actually bought one of them.
Isn't that precisely how malware has been spreading since day one?
Maybe it's an accent problem? I "OK Google" stuff all the time, including when I'm driving in my less than silent car, and have very little problem with it.
Am I on Digg?
But this one is on the internet.
I've tried Remix and yes, you can.
I suspected as much.
Is this an iOS thing? If I make in app purchases on any of my Android devices they are carried across to any of the devices I'm signed in to.
Purely anecdotal, but from what I've seen it's people aged 4 to 40+.
And a fuck load of them at that. Also it's good to see groups of kids out and about walking and riding places rather than just loitering around with "nothing to do".
There is no time like the present for postponing what you ought to be doing.