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The mouse is an excellent model for investigations of stroke and neural injury. However, there is a paucity of long term functional outcome measurements for the mouse. We, therefore, developed a sensorimotor functional test (corner test) and applied this test to a model of focal cerebral ischemia in the mouse. Male C57/6J mice (n=20) were subjected to… (More)
- Guang Liang Ding, Michael Chopp, David J. Poulsen, Lian Li, Changsheng Qu, Qingjiang Li +5 others
- PloS one
- 2013
We assessed the effects of low dose methamphetamine treatment of traumatic brain injury (TBI) in rats by employing MRI, immunohistology, and neurological functional tests. Young male Wistar rats were subjected to TBI using the controlled cortical impact model. The treated rats (n = 10) received an intravenous (iv) bolus dose of 0.42 mg/kg of methamphetamine… (More)
- Zhenggang Zhang, Li Zhang, Manuel Yepes, Quan Jiang, Qingjiang Li, Polly Arniego +3 others
- Circulation
- 2002
BACKGROUND After stroke, the thrombolytic effect of tissue-type plasminogen activator (tPA) in the intravascular space is beneficial, whereas its extravascular effect on ischemic neurons is deleterious. We tested the hypothesis that neuroserpin, a natural inhibitor of tPA, reduces tPA-induced neuronal toxicity and increases its therapeutic window for… (More)
- Lian Li, Quan Jiang, Li Zhang, Guangliang Ding, Zheng Gang Zhang, Qingjiang Li +6 others
- Brain research
- 2007
To dynamically investigate the long-term response of an ischemic lesion in rat brain to the administration of sildenafil, male Wistar rats subjected to embolic stroke were treated with sildenafil (n=11) or saline (n=10) at a dose of 10 mg/kg administered subcutaneously 24-h after stroke and daily for an additional 6 days. Magnetic resonance images were… (More)
- Guangliang Ding, Quan Jiang, Lian Li, Li Zhang, Zheng Gang Zhang, Karyn A Ledbetter +3 others
- Brain research
- 2006
Thrombolytic therapy with rtPA increases the risk of hemorrhagic transformation (HT) after cerebral ischemia. We employed contrast enhancement MRI with Gd-DTPA to detect HT in a rat model of embolic stroke treated with rtPA and a glycoprotein IIb/IIIa receptor antagonist, 7E3 F(ab')2, at 4 h after embolic stroke. Male Wistar rats were subjected to embolic… (More)
Using magnetic resonance imaging (MRI) protocols of T(2)-, T(2)*-, diffusion- and susceptibility-weighted imaging (T2WI, T2*WI, DWI, and SWI, respectively) with a 7T system, we tested the hypothesis that treatment of embolic stroke with erythropoietin (EPO) initiated at 24 hr and administered daily for 7 days after stroke onset has benefit in repairing… (More)
We treated traumatic brain injury (TBI) with human bone marrow stromal cells (hMSCs) and evaluated the effect of treatment on white matter reorganization using MRI. We subjected male Wistar rats (n = 17) to controlled cortical impact and either withheld treatment (controls; n = 9) or inserted collagen scaffolds containing hMSCs (n = 8). Six weeks later, the… (More)
To increase the sensitivity of MRI parameters to detect tissue damage of ischemic stroke, an unsupervised analysis method, Iterative Self-Organizing Data Analysis Technique Algorithm (ISODATA), was applied to analyze the temporal evolution of ischemic damage in a focal embolic cerebral ischemia model in rat with and without recombinant tissue plasminogen… (More)
BACKGROUND Functional recovery after brain injury in animals is improved by marrow stromal cells (MSC) which stimulate neurite reorganization. However, MRI measurement of neurite density changes after injury has not been performed. In this study, we investigate the feasibility of MRI measurement of neurite density in an animal model of traumatic brain… (More)
- Philip D. Kiser, Jianye Zhang, Mohsen Badiee, Qingjiang Li, Wuxian Shi, Xuewu Sui +3 others
- Nature chemical biology
- 2015
Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for rod and cone opsins. The mechanism by which RPE65 catalyzes stereoselective retinoid isomerization has remained elusive because of uncertainty about how retinoids bind to its… (More)


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fire places
yellow tiled fireplace - lovely soft wall colour too. I love the idea of a brightly coloured fireplace and soft walls. Gorgeous floor too.
Love the idea of toughening up a soft Georgian fireplace with tiles
Love the tiles behind the cream log burner
Flush tiled hearth Woodburner installed
Google Image Result for http://housetohome.media.ipcdigital.co.uk/96%257C00000cfbb%257C45ff_orh550w550_aarrow.jpg
Using #herringbone tile around the #fireplace
Turquoise and yellow tiled/ B&W accent. This patten could tie the new black counters in with old yellow tile c. 1926 ...around stove alcove and above backsplash?
Simple greys are so on trend. Give them a lift by adding a dash of vibrant yellow. Why not make a eyecatching feature with these Toledo wall tiles. http://bq.co.uk/Q3TGlp #tiles #yellow #contemporary
Living room with wood burning stove | Living room decorating ideas | Woodburning Stoves | Image | Housetohome
Woodburner with tiles behind

subset: commoncrawl


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Nassim Nicholas Taleb coined the term "Antifragility" in his book of the same name. Antifragility…
From Glider to WII Fighter: Lessons Learned from Glider Design
After Germany and its allies lost WWI, motor flying became strictly prohibited under the Treaty of Versailles. Creativity often springs from constraints, and so, paradoxically, the ban imposed by the Allies encouraged precisely what they had actually wanted to thwart: the growth of the German aviation industry. As all military flying was prohibited under the Treaty, […]
The von Kármán Vortex Street and Tacoma Narrows Disaster
On November 8, 1940 newspapers across America opened with the headline "TACOMA NARROWS BRIDGE COLLAPSES". The headline caught the eye of a prominent engineering professor who, from reading the news story, intuitively realised that a specific aerodynamical phenomenon must have led to the collapse. He was correct, and became publicly famous for what is now known as […]
How Quickly Do Bubbles Rise in a Pint of Beer?
The material we covered in the last two posts (skin friction and pressure drag) allows us to consider a fun little problem:
How quickly do the small bubbles of gas rise in a pint of beer?
To answer this question we will use the concept of aerodynamic drag introduced in the last two posts […]
Boundary Layer Separation and Pressure Drag
At the start of the 19th century, after studying the highly cambered thin wings of many different birds, Sir George Cayley designed and built the first modern aerofoil, later used on a hand-launched glider. This biomimetic, highly cambered and thin-walled design remained the predominant aerofoil shape for almost 100 years, mainly due to the fact that […]
On Boundary Layers: Laminar, Turbulent and Skin Friction
In the early 20th century, a group of German scientists led by Ludwig Prandtl at the University of Göttingen began studying the fundamental nature of fluid flow and subsequently laid the foundations for modern aerodynamics. In 1904, just a year after the first flight by the Wright brothers, Prandtl published the first paper on a […]
Dimensional Analysis: From Atomic Bombs to Wind Tunnel Testing
Despite the growing computer power and increasing sophistication of computational models, any design meant operate in the real world requires some form of experimental validation. The idealist modeller, me included, wants to believe that computer simulation will replace all forms of experimental testing and thereby allow for much faster design cycles. The issue with this […]
Supersonic Aerodynamics: Designing Rocket Nozzles
(Caveat: There is a little bit more maths in this post than usual. I have tried to explain the equations as good as possible using diagrams. In any case, the real treat is at the end of the post where I go through the design of rocket nozzles. However, understanding this design methodology is naturally easier […]
Control and Stability of Aircraft
One of the key factors in the Wright brothers' achievement of building the first heavier-than-air aircraft was their insight that a functional airplane would require a mastery of three disciplines:
Lift Propulsion Control
Whereas the first two had been studied to some success by earlier pioneers such as Sir George Cayley, […]
What Creates Lift – How Do Wings Work?
How airplanes fly is one one of the most fundamental questions in aerospace engineering. Given its importance to flight, it is surprising how many different and oftentimes wrong explanations are being perpetuated online and in textbooks. Just throughout my time in school and university, I have been confronted with several different explanations of how wings create […]
The Navier-Stokes Equation
The name we use for our little blue planet "Earth" is rather misleading. Water makes up about 71% of Earth's surface while the other 29% consists of continents and islands. In fact, this patchwork of blue and brown, earth and water, makes our planet very unlike any other planet we know to be orbiting other stars. […]
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