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found this really awsome hack and need to scan it for viruses can anyone give me a link to muli virus scan sight plz.
what the hack? lol where'd u find it?
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Hennerleys5 Feedback reviews, 100% positive
Hennerley's is an established family run company based in Chorley, Lancashire and through time and two generations of experience have grown to become a specialists Block Paving, Patios, Driveways, tarmacadam and groundwork's company.
Latest Driveways feedback review:
By marxparo on 9th Dec, 2011
CPC Property Services9 Feedback reviews, 100% positive
A small family firm,who treat your property as if it was our own. With a full team of trusted skilled sub contractors working with us, for a complete job from start to finish , with the eye to detail that you require , large portfolio of work available.
Latest Extensions feedback review:
By rod_26 on 31st May, 2015
Darren Finney Builders6 Feedback reviews, 100% positive
Latest Bricklaying feedback review:
By reddfc on 17th Sep, 2015
RGC Builders & Son11 Feedback reviews, 100% positive
Established in 1980 RGC Builders and Son is a family run business offering a reliable service at a competitive price, with customers at the forefront of all we do. With our free quotation service and a wealth of experience, there are never any jobs too big or too small for...
Latest Extensions feedback review:
By marty56 on 24th Feb, 2012
Solid Brick LTD9 Feedback reviews, 78% positive
Bricklayer with over 25 years experience. We work on domestic and commercial properties from garden walls to house extensions and new house builds. Also house repointing. We also do flagging and block paving , patios and drive ways, Fencing and much more.
Latest Bricklaying feedback review:
By karen_mno on 24th Jan, 2017
M.S.R Construction7 Feedback reviews, 100% positive
M.S.R. Construction can provide a full range of building services specialising in stone conversions ,new builds and extensions. We are a partnership with 20 years experience in the construction industry comprising of a highly skilled stonemason/bricklayer a joiner and 2...
Latest Extensions feedback review:
By david_grant_35 on 29th Jul, 2015
LAJ Property services5 Feedback reviews, 100% positive
My company offers a great reliable services to the general public. We carry out a very high standard of work whilst understanding we have to be competitive with our quotations. We undertake many aspects of work from building extensions to bathroom and kitchen fitting and...
Latest Extensions feedback review:
By tommybouy on 27th Jun, 2016
O.Morris Construction2 Feedback reviews, 100% positive
Hi I'm Ollie, here at O. Morris Construction we make your ideas into reality. Offering a reliable, high quality service in all aspects of building work including: - Bricklaying - Pointing - Plastering - Tiling - Roofing - Fencing - Decorating Contact for a free,...
Latest Plastering feedback review:
By lsconce on 30th Mar, 2016
JD Building & Maintenance2 Feedback reviews, 100% positive
JD Building Maintenance is an established business with over 10 years experience. All aspects of building work can be undertaken. No job is too big or too small.
Latest Extensions client reference:
Reference taken by MyBuilder on 31st Jan, 2017
Darbyshire Brickwork & Patio Designs32 Feedback reviews, 94% positive
Darbyshire Brickwork & patios take full pride in all work and use fully qualified tradesmen only. Time served bricklayer. Built new builds on building sites and done 8 extension builds around the north west and have been operating for 12 years and built good reputation and...
Latest Extensions feedback review:
By ontopoftheworld on 2nd Jun, 2016
Robert Wilson Joinery Services3 Feedback reviews, 100% positive
we work hard to make your dreams a reality. Working closely With local Trades and supplyers who really have the customers best interests at heart,delivering a project that is second to none.All the the buisness we work with have years of experiance and are well respected in...
Latest Extensions client reference:
Reference taken by MyBuilder on 14th Jul, 2016
mather brickwork ltd46 Feedback reviews, 100% positive
Experience extension builder and time served bricklayer for over 20 years.Started Mather Brickwork ltd 10 years ago.I have a professional attitude towards work, i provide a full extension build with a friendly and honest service with a high standard of work. My prices are...
Latest Extensions feedback review:
By scbsofla on 16th Aug, 2016
Andy Kille Building and Property Maintenance34 Feedback reviews, 100% positive
Hi, my name is Andy and I have been in the building trade for 24 years, my trade is a bricklayer but all type of building work can be catered for. Thanks
Latest Roofing feedback review:
By davelynam on 23rd Mar, 2015
Hayden Pasquill12 Feedback reviews, 92% positive
I will offer a good reliable and honest service .
Latest Extensions feedback review:
By abizaman on 13th Oct, 2015
Absolute Building & Roofing2 Feedback reviews, 100% positive
I am a multi skilled builder and time served bricklayer. I have been in the business for 40 years, specialising in extensions but no job to small. All my work is done to an excellent standard and comes with a 20 year guarantee. Port folio on request.
Latest Bricklaying feedback review:
By jamescawthray on 27th Jan, 2017
Need a tradesman?
Post a job on MyBuilder to find a quality, local tradesperson.
How MyBuilder works
1. Post a job
First, create a job listing for your extensions project. It's quick, easy and free - the first step to finding recommended extension builders in PR6, Chorley.
2. Hire a tradesman
Having met our recommended extension builders in PR6, Chorley and read customer reviews, you're ready to decide which extension builders to hire.
3. Leave feedback
After your project is successfully completed, you can leave a review for your extension builders. This review helps you and future MyBuilder users.
What our customers say
- "I'm really pleased and have to say your web site is a simple but fantastic idea and have already recommended it to others. Thanks!"
- Ade and Jodi
Tradesmen in PR6, Chorley
- Architectural Designers
- Bathroom Fitters
- Bricklayers
- Carpenters & Joiners
- Carpet fitters
- Chimney & Fireplace Specialists
- Conservatory Installers
- Conversion Specialists
- Damp Proofing Specialists
- Demolition Contractors
- Driveway Pavers
- Electricians
- Extension Builders
- Fascias, Soffits and Guttering Specialists
- Fencers
- Flooring Fitters
- Gas Engineers
- Groundworkers
- Handymen
- Heating Engineers
- Insulation Installers
- Kitchen Fitters
- Landscape Gardeners
- Locksmiths
- Loft Conversion Specialists
- New Home Builders
- Painters & Decorators
- Plasterers
- Plumbers
- Restoration & Refurb Specialists
- Roofers
- Security System Installers
- Stonemasons
- Tilers
- Tree Surgeons
- Window Fitters
- All Tradesmen

subset: commoncrawl


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Walmart is offering a free Welcome Baby Box when you fill out this form. Walmart's Welcome Box delivers free stage-relevant product samples to help you get a head start with Baby's development. Boxes available while supplies last. Products will vary.
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Is Moments Wedding Videos incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Ireland provides information regarding Moments Wedding Videos in Blarney Cork. Moments Wedding Videos is located at Blarney Cork and provides Photography services. Contact them on (021) 438 1036.
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CCGetMAC (youngzsoft.ccgetmac.ccgetmac) is a Windows software application that has been discovered and submitted by users of Software.com. The latest version that our users have reported running on their systems is CCGetMAC 3.9.
Operating System: Windows
File name: CCGetMAC.exe
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Product Version: 3.9
Internal Name: CCGetMAC.exe
Copyright: (c) Youngzsoft. All rights reserved.


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As millions of people around
the world heard the news of Prince George's arrival,
The morning after the birth was officially announced, commuters opening UK's Metro newspaper were greeted with a topical and refreshing Coca-Cola ad dedicated to the royal mum and dad. The creative was shared on Facebook and Twitter almost immediately, and within 30 minutes the iconic Coca-Cola sign in central London's Piccadilly Circus displayed a short and sweet message: "Time for a Royal Celebration. Share a Coke with Wills. Share a Coke with Kate."


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Mexican federal prosecutors must apologize to three indigenous women who were maliciously prosecuted and jailed—in a case that charts a new route to accountability.
Sign up to receive updates from the Open Society Foundations.
Mexican federal prosecutors must apologize to three indigenous women who were maliciously prosecuted and jailed—in a case that charts a new route to accountability.
Economic surveys that don't take into account unpaid domestic work misrepresent a society's labor activity—and diminish work done by women.
The country continues to thrive despite multiple bomb attacks, including this week's at Istanbul's Atatürk Airport.
If the vision of equal access to justice for all is to become a reality, more countries around the world will need a sustainable nationwide system for legal services.
The president has made fighting corruption a top priority. Why is progress so slow?
The farcical process not only fails to achieve justice for Palestinians killed or harmed by Israeli soldiers—it lends a sheen of false legitimacy to the occupation itself.
To realize the European Union's original ambitions, those who are committed to open society principles must address the politics of fear.
The impact of the UK's decision to quit the European Union will go far beyond an immediate loss of economic confidence, and may challenge the country's historic faith in open society values.
We must mobilize to fight for true and lasting changes to immigration policy to allow all people, regardless of where we were born, to contribute fully to our communities.
A series of investigations and indictments have shed light on a campaign finance system that consistently operates outside the law.
When marginalized women are convicted of drug offenses in Indonesia, their best shot at avoiding the death penalty is early access to justice.


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Dewas to Nashik
Updated on : Feb 28, 2017 08:05 AM
Dewas to Nashik - Bus Fare & Timings
Dewas to Nashik Bus tickets with lowest fare of Rs. 550 Average Bus Rating: 4.5/5 based on 118 customer reviews.
- Bus-operator From To Cheapest Fare
Hans Travels
Just a moment
Bhopal Travels
Just a moment
Dewas to Nashik Bus Services
There are 2 bus operator(s) providing bus service from Dewas to Nashik. The top bus operator(s) for Dewas to Nashik route is Hans Travels Indore. The first bus from Dewas departs at 07:45 PM and is operated by Verma Travels and the last bus departs at 08:45 PM and is operated by Verma Travels. The minimum fare from Dewas to Nashik Bus is Rs. 1250.00/- departing at 08:00 PM. One can also avail of Volvo AC, Volvo AC Sleeper, AC Sleeper, AC Seater, Non AC Sleeper, Non AC Seater on this route. The bus(es) usually take a maximum of 10 hours to complete the journey. Some of the other famous operators plying on this route are Chartered Travels.


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Checkpoint inhibitors for NSCLC An update Solange Peters, MD-PhD Oncology Department CHUV Lausanne
"In any trial you get the odd patient who does very well, but this is an order of magnitude above that.", Mick Peake, Glenfield Hospital
High mutational rates may contribute to increased immunogenicity Mutations in Cancer Cells Make Them Appear Different to the Immune System Lawrence MS, et al. Nature
Vogelstein, Science 2013 Melanomas and lung tumors display many more mutations than average, with~200 nonsynonymous mutations per tumor. These larger numbers reflect the involvement of potent mutagens. Accordingly, lung cancers from smokers have 10 times as many somatic mutations as those from nonsmokers.
Lung cancer is the main cause of cancer death worldwide
Rationale for immune therapy in NSCLC Liu H et al. Cancer Immunol Immunother 2012 Presence of TILs associated with increased recurrence-free survival 1 Recurrence-Free Survival (%) Survival Time (Months) FoxP3 + cell <3 FoxP3 + cell ≥3 Recurrence-Free Survival (%) Survival Time (Months) TIL – TIL + P=0.011 Higher NSCLC-Infiltrating Tregs associated with worse recurrence-free survival 2 1.Shimizu K, et al. J Thorac Oncol Horne ZD, et al. J Surg Res. 2011
NSCLC: An immune driven tumor? Tumour type Prognostic a tumour infiltrating lymphocytes b Immune-related spontaneous tumour regression c NSCLC Yes 1 Yes 13 (rare) CRCYes 2 Yes 14 BreastYes 3,4 No MelanomaYes 5,6 Yes 15 RenalYes 7,8 Yes 16,17 ProstateYes 9 No OvarianYes 10 No Head and neckYes 11 No CervicalYes 12 Evidence for cervical intraepithelial neoplasia 2/3 18,19 a Covers correlation with improved overall or progression-free survival, disease stage, or therapy outcome b The type of lymphocyte dictates where there is a correlation with improved or worsened outcome c Based on PubMed search conducted in October 2013 using the terms 'spontaneous regression' and the tumour type 1. Hiraoka K, et al. Br J Cancer. 2006;94:275–280; 2. Galon J, et al. Science. 2006;29:1960–1964; 3. Mahmoud SM, et al. J Clin Oncol. 2011;29:1949–1955; 4. Loi S, et al. J Clin Oncol. 2013;31:860–867; 5. Piras F, et al. Cancer. 2005;104:1246–1254; 6. Azimi F, et al. J Clin Oncol. 2012;30:2678–2683; 7. Siddiqui SA, et al. Clin Cancer Res. 2007;13:2075– 2081; 8. Donskov F, et al. Br J Cancer. 2002;87:194–201; 9. Flammiger A, et al. APMIS. 2012;120:901–908; 10. Zhang L, et al. N Engl J Med. 2003;348:203–213; 11. Badoual C, et al. Clin Cancer Res. 2006;12:465–472; 12. Piersma SJ, et al. Cancer Res. 2007;67:354–361; 13. Nakamura Y, et al. Lung Cancer. 2009;65:119–122; 14. Bir AS, et al. Anticancer Res. 2009;29:465–468; 15. Kalialis LV, et al. Melanoma Res. 2009;19:275–282; 16. Kawai K, et al. Int J Urol. 2004;11:1130–1132; 17. Kumar T, et al. Respir Med. 2010;104:1543–1550; 18. Øvestad IT, et al. Mod Pathol. 2010;23:1231–1240; 19. Castle PE, et al. Obstet Gynecol. 2009;113:18–25.
-> AG-specific antibodies & cytotoxic T cells -> enhancement of immune system cytokines cytokines checkpoint inhibitors checkpoint inhibitors Cancer vaccination therapy Cancer immunotherapy: any interaction with the immune system to treat cancer Cancer immunomodulation therapy Lung cancer immunotherapy Landscape Active: priming of the immune system Passive: delivery of compounds that may use immune system Antigen- specific Non-antigen- specific cetuximab cetuximab trastuzumab trastuzumab Targeted antibodies immunotherapy Monoclonal antibodies T cells engineering T cells engineering CARs CARs Dendritic cells Dendritic cells Cellularimmunotherapy Adoptive cell transfer
Hanahan & Weinberg. Cell 2011 Evading growth suppressors Enabling replicative immortality Tumour- promoting inflammation Activating invasion & metastasis Genome instability mutation Resisting cell death Degrading cellular energetics Sustaining proliferative signalling Inducing angiogenesis PD-1 PDL-1 Avoiding immune destruction Therapeutic Intervention at Cancer Hallmarks CTLA-4
NSCLC PHASE II, COMBINATION WITH CHEMOTHERAPY Ipilimumab Lynxh et al, JCO 2012
Ipilimimab Phase 2 CA : Study Schema
Lung cancer immunomodulation Ipilimumab irPFSOS
Ipilimumab: NSCLC phase III trial Squamous Cell NSCLC, stage IV. Primary EP: OS N=920, accrual completed
Clinical Development of Inhibitors of PD-1 Immune Checkpoint PD-1Nivolumab- BMS Fully human IgG4 mAbBristol-Myers SquibbPhase III Pidilizumab CT-011 Humanized IgG1 mAbCureTechPhase II Pembrolizumab MK-3475 Humanized IgG4 mAbMerckPhase III AMP-224Recombinant PD-L2-Fc fusion protein GlaxoSmithKlinePhase I PD-L1BMS Fully human IgG4 mAbBristol-Myers SquibbPhase I MedI-4736Engineered human IgG1 mAb MedImmunePhase III MPDL-3280AEngineered human IgG1 mAb GenentechPhase III MSB CEngineered human IgG1 mAb EMD SeronoPhase II
Anti-PD1/Anti PDL1: What do we know at the end of 2014? 1)Monotherapy treatment with various drugs accross histologies and molecular subtypes 1)In >2 line of NSCLC treatment (incl. maintenance) 2)In first line NSCLC treatment 2) The challenge of the biomarker
>2 ND LINE, PHASE 1 DATA Nivolumab Gettinger et al, ASCO 2014 and CMSTO 2014
Pts at Risk GroupDied/TreatedMedian OS, mo (95% CI) 1-year2-year 3-year 9.2 (5.3, 11.1) 14.9 (7.3, 30.3) 9.2 (5.2, 12.4) Months Since Initiation of Treatment Censored 3-year OS = 27% 2-year OS = 42% Nivolumab 1 mg/kg Nivolumab 3 mg/kg Nivolumab 10 mg/kg OS (%) 33 (17, 49) 56 (38, 71) 38 (26, 50) 15 (5, 30) 42 (24, 58) 20 (11, 31) 15 (5, 30) 27 (12, 43) 14 (7, 25) 26/33 23/37 50/59 1 mg/kg 3 mg/kg 10 mg/kg OS rate, % (95% CI) OS by Dose (data lock ) Pts were heavily pretreated; 54% had 3–5 prior therapies 50% of responders (11/22) demonstrated response at first assessment (8 wks) Responses were ongoing in 41% of pts (9/22) at the time of analysis
Characteristics of Responses Time to and duration of response while on ttt Ongoing response Time to response Response duration following discontinuation of ttt Time (Months) NSCLC Responders % unconvientional "immune-related" responses, with persistent reduction in target lesions in the presence of new lesions or regression following initial progression Manageable safety profile with no new safety signals emerging with all pts having >1 year of follow-up
Best Change in Target Lesion Tumor Burden by Tumor PD-L1 Expression Pts Positive Negative PD-L1 Status (5% cut-off) %33% Change in Baseline Target Lesions (%) 20 There was no clear association between PD-L1 expression and RR, PFS or OS (archival samples)
Exploratory Analysis of Response by Smoking Exposure VariableORR, % (n/N) [95% CI] a Smoking exposure >5 pack-years30 (20/66) [20, 43] ≤5 pack-years b 0 (0/14) [0, 23] Time since quitting (NO CORRELATION) >15 yrs prior26 (6/23) [10, 48] 6–15 yrs prior17 (2/12) [2, 48] 1–5 yrs prior 46 (6/13) [19, 75] Current smoker27 (6/22) [11, 50] 0/never smoker0 (0/10) [0, 31]
Nivolumab in EGFR M+
1ST LINE, PHASE 1 DATA MONOTHERAPY & COMBINATIONS Nivolumab Rizvi et al; Antonia et al, CMSTO 2014
PFS and OS With Nivolumab Monotherapy frontline PFS PFS at rate Wks24 = 40% PFS rate at wks24= 31% Time Since First Dose (Weeks) B/L OS Time Since First Dose (Weeks) B/L Sq Non-sq All treated pts Sq Non-sq All treated pts Non-sq (mPFS 15.6 wks) Sq (mPFS 15.4 wks) All treated pts (mPFS 15.6 wks) Number of Pts at Risk Non-sq (mOS NR) Sq (mOS 73.1 wks) All treated pts (mOS 98.3 wks)
Percent Changes in Target Lesion Tumor Burden by PD-L1 in first line B. Best percent change in target lesion tumor burden from baseline Positive Negative Pts PD-L1 Status (5% cut-off) Change in Baseline Target Lesion (%)a A. Percent change in target lesions from baseline Time Since First Dose (Weeks) Negative Positive PD-L1 Status (5% cut-off) Change From Baseline (%) -100
PFS and OS in NSCLC pts Treated With Nivolumab Plus Ipilimumab
Safety : Nivo + Ipi in NSCLC Treatment-related AEs led to discontinuation of any study drug in 37%, and included pneumonitis, increased ALT or AST, colitis or diarrhea, and allergic nephritis, ulcerative colitis, impaired gastric emptying, Miller Fisher syndrome, and pulmonary hemorrhage Most treatment-related AEs leading to discontinuation occurred during induction (15 pts, 31%)
1 st line combination with chemotherapy Patients Change in Baseline Target Lesions (%) Nivolumab 10 mg/kg + Gem/Cis Nivoluma b 10 mg/kg + Pem/Cis Nivolumab 10 mg/kg +Pac/Carb Nivolumab 5 mg/kg + Pac/Carb ORR for nivolumab plus chemotherapy in 1 st -line treatment are similar to those previously reported for chemotherapy alone
20 refractory after TKI failure, 1 naïve EGFR M+ patients PFS Time Since First Dose (Weeks) B/L OS Time Since First Dose (Weeks) B/L Number of Pts at Risk Nivolumab + erlotinib Nivolumab + erlotinib Nivolumab 3 mg/kg + erlotinib (mPFS 29.4 wks) Nivolumab 3 mg/kg + erlotinib (mOS NR) 18-month OS rate = 64% PFS rate at 24 weeks = 50% PFS (%) OS (%) PFS and OS in EGFR + NSCLC Treated With Nivolumab Plus Erlotinib
SQUAMOUS >2 ND LINE, PHASE 2 MONOTHERAPY DATA Nivolumab
Response to Nivolumab in SQ NSCLC Brain Metastasis 73 year-old male, stage IIIB, former smoker Prior radiotherapy (mediastinal), 3 prior systemic regimens (cisplatin/gemcitabine, docetaxel, vinorelbine) No prior CNS-directed radiotherapy Pre-treatmentWeek 14Week 68
Overall Survival : All Treated Patients Median follow-up for survival: 8 months (range, 0–17 months) Nivolumab 3mg/kg Number of Patients at Risk 1-year OS = 41% Median OS = 8.2 months Overall Survival (Months) Overall Survival (%) Median OS, months (95% CI)8.2 (6, 11) 1-year OS rate, % (95% CI)41 (32, 50) Number of events72/117
NSCLC POOLED ANALYSIS 1ST AND SUSEQUENT LINES, MONOTHERAPY Pembrozilumab Garon et al, ESMO 2014
Pembrolizumab (MK-3475) In all evaluable patients, regardless of dose or PD-L1 status ORR (confirmed and unconfirmed): 20% by RECIST v1.1, 18% by irRC DCR (confirmed and unconfirmed): 40% by RECIST v1.1, 52% by irRC PDL1 +: RR 23%, PFS 11 wks PDL1 -: RR 9%, PFS 10 wks Herbst, ASCO 2014
Immunosuppressive properties of previous cytotoxic agents through lymphocytes depletion? Impact of steroids as antiemetic co-medication on the immune system? Progressive T cell exhaustion during tumor progression? Increase in expression of PD-L1 in the course of the disease?
Focus on pembrozilumab first line data 10 mg/kg Q3W 10 mg/kg Q2W 2 mg/kg Q3W * Still on treatment * * *** * * * * * * * * * ** * * * * * Interim median PFS c : 27.0 weeks (95% CI, ) by RECIST v1.1 per central review 37.0 weeks (95% CI, 27.0-NR) by irRC per investigator review
>2 ND LINE, PHASE 1 DATA MPLD3280A Soria et al, WCLC 2013 and Brahmer et al, 2014
Diagnostic Population a (n = 53) ORR b % (n/n) PD Rate % (n/n) IHC 383% (5/6) 17% (1/6) IHC 2 and 346% (6/13) 23% (3/13) IHC 1/2/331% (8/26) 38% (10/26) All Patients c 23% (12/53) 40% (21/53) OVERALL RESPONSE RATE: 21% (N=175) MPDL3280A Phase Ia: Best Response by PD-L1 IHC Status - NSCLC Soria, ESMO 2013
MPDL3290A: Specific predictors Horne et al., WLCC 2013 #MO18.1
Histology is not predictive through all available data Squamous Carcinoma Non- squamous Nivolumab (PD-1) 17% (9/54) 18% (13/74) MPDL3280A (PD- L1) 27% (3/11) 21% (9/42) Pembrolizumab (irRECIST) 25% (66/262) 23% (60/262)
THE CHALLENGE OF THE BIOMARKER PD-L1 as a predictive biomarker / inclusion criteria
Intricate role of PD-1 signalling with different cell types Image from J. Allison
AgentAssayAnalysisDefinition of positivityPD-L1 expression Nivolumab (anti-PD-1) 1 4 Dako automated IHC assay (28-8 rabbit Ab) Analytically validated Archival FFPE1% and 5% cut-off among >100 evaluable tumour cells 56%: 1% cut-off 49%: 5% cut-off Pembrolizumab (anti-PD-1) 5,6 Dako automated IHC assay (22C3 mouse Ab) Archival FFPETumour dependent: - Melanoma > 1% - NSCLC PD-L1 (+): Strong (≥50%) and weak staining (1–49%) PD-L1 (–): no staining ~25%: ≥50% staining ~45–70%: ≥1% staining MPDL3280A (anti-PD-L1) 7,8 Ventana automated clinical research IHC assay Archival FFPEPD-L1 (+): IHC 3 (≥10%), IHC 2,3 (≥5%), IHC 1,2,3 (≥1%) PD-L1 (–): IHC 1, 0 or unknown 11%: IHC 3 75%: IHC 1, 0 MEDI-4736 (anti-PD-L1) 9 First-generation or Ventana IHC Automated Assay (in dev.) Archival FFPENot reported PD-L1 analysis: differences in evaluation and interpretation
Drug/ Sponsor Nivolumab BMS Pembrolizumab MSD (Merck) MPDL3280A Genentech MEDI4736 MedImmune Assay28-822C3SP263 Cells scored Tumor cell membraneTumor cell (and stroma)Infiltrating immune cells TissueArchivalRecentArch./Recent Setting1 st line2L ++1 st line2L ++ Cut- point 5%1%5%1% 50%1%5%10% ORR in PD-L1 + 50% N=10 13% N=38 15% N= % N= % N=177 37% N=41 31% N=26 46% N=13 83% N=6 39% N=13 ORR in PD-L1 - 0% N=7 17% N=30 14% N=35 ??? 9-13% N=40 11% N=88 20% N=20 18% N=33 18% N=40 5% N=19 Hamid, ASCO 2013, #9010 Herbst, ASCO 2013, #3000 Powderly, ASCO 2013, #3001 Spigel, ASCO 2013, #8008 Topalian, NEJM 2012 Grosso, ASCO 2013, #3016 Brahmer, ASCO 2014, #8112 Gettinger, ASCO 2014, #8024 NIVOMPDL3280 A Daud, AACR 2014 Ghandi, AACR 2014 Rizvi, ASCO 2014, #8009 Garon, ASCO 2014, #8020 Pembro Segal, ASCO 2014, #3002 Brahmer, ASCO 2014, #8021 MEDI4736 PD-L1 as a biomarker in NSCLC
a Patient experiencing ongoing benefit per investigator. Patients first dosed at 1-20 mg/kg by Oct 1, 2012; data cutoff Apr 30, MPDL3280A Phase Ia: Duration of Treatment in Responders - NSCLC Duration of Treatment and Response Time (Weeks) Histology IHC Nonsquamous IHC 0 Squamous IHC 3 Nonsquamous IHC 0 Nonsquamous IHC 1 Nonsquamous IHC 0 Squamous IHC 2 Nonsquamous IHC 3 Squamous IHC 3 Nonsquamous IHC 3 Nonsquamous IHC 0 Nonsquamous IHC 3 Nonsquamous IHC 1 a 47 PD-L1 expression is dynamic PD-L1 is heterogeneous within tissue PD-L1 "threshold" is to be defined (tumour material, mAB, technique, sampling, criteria) Importance of co-localization with TILs
Stroma or tumour cells? HNSCC example
Tumor Infiltrating Lymphocytes as a biomarker? The HNSCC example Presented by: Tanguy Seiwert Diffuse infiltration with CD8+ TILs in HNSCC Absence of TILs in HNSCC
PD1/PDL1 summary Clear evidence of anti PD1/PD-L1 activity Optimal dose? Treatment sequence? Combination strategy Chemotherapy Other checkpoint inhibitor Targeted therapy (TKI) Pharmacodynamic biomarkers of activity? (circulating CD8+Ki-67+ T cells and/or plasma proteins (eg, IL-18))
PD1/PDL1 summary Predictors of activity: PD-L1 as the biomarker? Selection by PD-L1 expression likely enhances response rate Activity seen in PD-L1 neg How do we define PD-L1 positivity? How does PD-L1 evolve over time ? Is PD-L1 more strongly expressed in defined patients subgroups (smokers?) Randomized trials with PD-L1 stratification awaited!
PD1/PDL1 summary Phase III trials: -Ongoing in first line vs platinum-based chemotherapy in PD-L1+, with/out crossover -Completed in second line vs docetaxel in squamous and non-squamous subtypes -Ongoing in second line vs docetaxel in PD-L1+ -Starting in radically resected stage IB-III adjuvant setting (PDL1+ and all) -Starting in consolidation after radical chemoradiotherapy in stage III
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Berkshire Hathaway HomeServices First Realty
(515) 453-7200
Last Updated: 2/23/2017 6:17 PM
Description for Industrial Park Indianola, IA 50125
Great place to build your business! 12 Acres M/L with great access to Hwy 65/69 and approx 14 miles to the DSM Airport. Land lays south of the current building. Utilities are easy to access in the Indianola Industrial Park.
Listing Information
School Information
Room Information
Exterior / Lot Features
Concrete Road
Financial Considerations
Inside AccessTM
Current market conditions for Industrial Park
Active Market Trends
Source:MLS DATA
Median list price$243,900
Days on market109
Properties for sale67
Sold Market Trends
Source:MLS DATA
Median sold price$161,000
Sales to list price9,735.0%
Properties sold58
Median sq ft price$132
Arrows indicate 90 day trend
Listing Price History for Industrial Park
Indianola Real Estate
Indianola is located in Iowa. Indianola, Iowa 50125 has a population of 14,787.
The median household income in Indianola, Iowa 50125 is $52,872. The median household income for the surrounding county is $62,778 compared to the national median of $53,046. The median age of people living in Indianola 50125 is 32.7 years.
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Incredible Indian Tours
Best Exotic Marigold Hotel, Heritage Hotel Tour India, Rajasthan Group Tour,
Welcome to the India of The Best Exotic Marigold Hotel. Join us and experience some of the India and sights portrayed in the multi award nominated film… Ride auto & cycle rickshaws through Jaipur, visit Madge's exclusive 'Viceroy's Club' and see where Sonny woos Sunaina at the Stepwell. Have a gin & tonic on the terrace overlooking the lake in Udaipur and you'll even get to stay at the Marigold Hotel itself, which thankfully is not quite as run down as portrayed in the movie.
In addition there are amazing Moghul sights in Delhi, the truly incredible Taj Mahal in Agra, and the wonders of Rajasthan, the 'Land of Kings'. Included in this tour are the must do's and we have allowed plenty of free time for another of the wonders of India – Shopping.
Experience Incredible India and the Complete Rajasthan on this Small Group Tour, fully escorted within India by a western tour leader and local guides for various activities and sightseeing.
Dates: 6-16 October 2013
Prices: From $3490 per person
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Come with us on an Incredible Group Tour to India or Nepal.
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70 cents of residential land for sale at Piravom near to town. suitable for constructing house fully or partially with all amenities including road side and also lorry site .Price negotiable. Price: 4.75 lakhs per cent.
I advertised my property, 108 cents of Residential Land in Cherthala in helloaddress.com on October 2nd 2015, as a featured property for one month. Before my package got expired I got many enquires and found the right buyer for my property too. I am very much satisfied by the service. Thanks to helloaddress.com for the excellent service and for quick response I got.


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Rockler Curly Maple Pen Blank
Home > Rockler > Wood Turning > Pen Blanks > Natural Wood Pen Blanks
With its shimmering, wavy grain, Curly Maple could be called the Goldilocks of the wood world. These blanks are selected for the best curly figure and even color. With sharp tools, the wood turns well, and finish will really make the grain ´´pop.´´ If different colors are desired, using dyes will give stunning results. If a natural look is desired, but with maximum shimmer, we recommend oil finishes such as tung oil or boiled linseed oil.


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Ok so as an update to this I believe that my issue may be that I can't address my SD card. I am booting from it so it is connected but I noticed that in my version of u-boot that the mmcinit command is no longer available. I have been looking through the u-boot docs all morning and haven't found anything saying that. I have tried using "mmc info" and have found that it is aware of the card so I assume, yes I know that makes an ass out of me, that the mmc initilized at startup now so they dropped the command. I still am not clear on how this effects the syntax of "fatload"
Kendall York <email@example.com>
"firstname.lastname@example.com" <email@example.com>
Friday, August 19, 2011 9:17 AM
[Gumstix-users] Syntax
Hey guys. I am still stuck on trying to load the MLO file from my bootable SD card to NAND. I have the instruction page but am not having much luck with the syntax. I was hoping some out there would understand it. The command I am stuck on is fatload. Here is the syntax
fatload <interface> <dev[:part]> <addr> <filename> [bytes]
The example uses the command like this
Overo # fatload mmc 0 $loadaddr MLO
Based on what I know the way this is working is fatload pulls a file into memory from a FAT file system and holds it to be placed in NAND later. (mmc 0) refers to the location of the file. In this case it is on an SD card and is the first file on the card. Question there is does fatload always take the first file? Next is the <addr> argument. To me it looks like this is the temp file that will hold MLO until you write to NAND. So is this arbitrary? Last is the name of the file, MLO. Why does it need this if it knows where the file is held on the drive? Hope I am not to far off.
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Makes 5 cups
+ Add To Shopping List
2 (8-oz.) packages cream cheese, softened
1 cup unsalted butter, softened
1 teaspoon vanilla extract
2 cups powdered sugar, sifted
Total: 10 Minutes
1. Place first 3 ingredients in the bowl of a heavy-duty electric stand mixer, and beat at medium speed using the paddle attachment until smooth. Gradually add powdered sugar, beating at low speed until blended after each addition. Beat at medium-high speed 3 minutes or until light and fluffy.
Created date
October 2012


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text: Recently my thoughts have returned to the phenomena of repetition, duplication, and redundancy in the Bible. This occurs on several levels: entire passages running many verses of one book that are repeated word-for-word either in same book or different book (people are often surprised by this!); sometimes there are partial verses or lengthy phrases that reappear again and again; individual words are repeated (like "Holy, Holy, Holy"); and of course, more broadly there are similar pericopae & teachings that found in several places (thus the title we use for Deuteronomy). Some scholars have suggested that the redundancy in the scriptures was part of God's plan for the preservation of His words. Redundancy is not necessarily a bad thing (ask an IT person). I have personally explored the first two levels above in minor ways, and I began to keep a list virtually verbatim passages and verses. But I know there must be many more that I haven't noticed, so I am seeking assistance: if you are familar with what are essentially duplicate verses from the canonical books of the Protestant Bible would you please include the references in a post in this thread. Let's exclude the obvious: material shared among the synoptic gospels in the NT, and the parallels between Kings-Samuel-Chronicles in the OT. Thanks!


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Local Little Boy Celebrates Veterans Day [WATCH]
While hearing a military song on the radio, in honor of Veterans Day, this super cute little boy just had to dance!!!!
While hearing a military song on the radio, in honor of Veterans Day, this super cute little boy just had to dance!!!!
On this day, let us all take a moment to thank and acknowledge those men and women of the Tri-State who serve or have served our incredible county. #USA
In honor of Veterans Day, Mission BBQ in Evansville is offering free sandwiches to all veterans and active duty military personnel.
For the first time since its inception, the annual Four Freedoms Veteran's Parade will "march" its way down Franklin Street this Saturday at 2:30 p.m.
The University of Southern Indiana Dental Hygiene Clinic will once again offer free dental cleanings to the men and women of the armed forces as a way of saying, "thanks" for all they do to keep us safe at home and abroad.
On Wednesday, the Evansville Rescue Mission (ERM) took four residents, all military veterans, out for an afternoon of lunch and shopping for new clothes.
April 11th is the deadline for mail call, so get your letter or card in the mail now, and WWII veterans will receive them!
In honor of Veterans Day, we asked our Facebook fans to share photos of their veterans.
Across the country on Monday, Americans observed Veterans Day, commemorating the service of its military men and women, active and retired, or killed in action.
This veteran is ready to get his life back on track.
After being killed in the line of duty in Iraq seven years ago, Marine Sergeant Brock Babb will be honored for making the ultimate sacrifice with the dedication of a new American Legion Post in his name.
The organization's fourth annual "Totes for Hope" campaign is accepting donations through Monday, November 5th.


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ANAHEIM Undefeated Orange League champion last year, Katella might have had its confidence shaken recently with two league losses, one coming a week ago.
However, after a 47-0 beating of Savanna on Friday night at Glover Stadium, the Knights are once again at the doorstep of the postseason.
TJ Ashmeade rushed for 255 yards and four touchdowns and the Katella defense held Savanna to 4 yards in a game that was never in doubt.
"Honestly for us, it's confidence," Katella coach Fred DiPalma said. "We got knocked down a few times. I'm proud of how we responded."
The win gives the Knights (6-3, 2-2) sole possession of third place with a game against Anaheim on Thursday remaining.
Savanna (1-8, 0-4) finishes its season next Friday against Century.
Katella took the opening kickoff and called seven consecutive run plays, the last resulting in an Ashmeade 22-yard touchdown.
Ashmeade added scoring runs of 4 and 15 yards in first half, rushing for 153 yards on 18 carries.
The senior later tacked on a 52-yard touchdown run.
Defensively, Katella recorded five sacks, a safety and forced two turnovers while allowing Savanna only two first downs, one via penalty.
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At least 3 of them allegedly have interested parties vying for their services already. Their valuations won't go up much if they aren't playing first team football.
Sad but true.
Sent from my iPhone using Tapatalk Pro
..or he's just an inexperienced first team manager who is going with individuals he knows very well, trusts and ones that he knows will give 100% for the team.
Whatever he's doing it aint working.
Why the fuck have we got another interim manager at the helm?
Oh yeh.... Cuntwaz.
Brazil is doing he best he can, and I'm great full he's bringing through the youth.
Shame we rarely seem to capitolise on our glorious academy by getting a good few seasons before selling on.
Anyway, fuckwad out
Pork - Stuffing - Apple Sauce
£20 on McCormack @13-2 for first goal & his penalty was shit, I was fucking seething.
So pretty much everyone who actually went to the game thought we did OK a probably deserved a draw against a decent Wednesday team. Bearing in mind we've been shocking all season and we were starting with 5 acad graduates I'm really not too bothered. We also managed to play the impossible 4 4 2 without getting absolutely raped, i'm pretty sure this team is going to start stringing a run of wins together starting next week and feel very confident I everything GB is doing..
We didn't play 442 until Britt came on. Before that it was 4231.
"Outside the family life, there is nothing better than winning the European Cups." Brian Clough
Everything is laboured, we attack slowly and by the time we are up the pitch all opposition players and back. We are not creating any chances at all and that's the worrying thing. We were kept in the game by a piece of brilliance again by a 17 year old.
Time to start attack as a team and defending as a team, and not playing this square football that goes nowhere. HP, or somebody with pace and flair needs to be involved against Wigan or I can't see us winning that match. Our away form has been so far this season because we cannot counter attack.
We have lost more points from winning positions than any other team this year.
We also seem to take ages to get going in matches and when we do it's too late
Although we seem to of played well yesterday
Time to stop with it and play him in the first team. If his exclusion from the first team is due to his ability then you have to question the judgement of GB, as I would say it's pretty clear what we are missing.
Yes very baffling, yet Kasami gets game time... Clough only seen 5 mins of action in last two games, looked like he was about to be brought on but at 2-0 down but Forest pulled a goal back and then Brazil decided to bring Kasami on instead. Also anyone know why Teixeira hasn't even made the squad yet? Looks like another poor / wasted signing made this season... Think that count must be upto 15 this season which is ridiculous!
Oh by the way, Perquis has been training with the U23's and we are now looking for central defender free agents according to the Post. What an earth is that all about.


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I'm so greatful to Tripadvisor for helping me find this hotel. I didn't/couldn't spend a fortune on what was to be a short stop over on our way home. I did my homework and based on the reviews decided to stay at this hotel. Without a doubt we would stay here again. The rooms are nicely decorated, spacious and comfortable. Our bathroom was big enough for all of us to use simultaneously!! Anyone with young kids knows this often happens! Yes, the breakfast was a little pricey, but no more so than what other hotels charge. I also didn't find the front desk staff particularly friendly, but they weren't rude. The one person that stands out, and I can't remember his name, but he was the gentlemen that took our bags in & helped find us parking. He ran back & forth in the rain trying to find us a spot. Unfortuneately it rained most of the time we were there, so we couldn't/didn't have use for the pool, but it is a lovely spot to sit for breakfast or afternoon tea. The only caution I would give is to not asked for a room with a balcony. I don't know if they charge more for these, I know I would have been disappointed had I asked for a balcony only to have a view of the inner courtyard parking lot!!
- Official Description (provided by the hotel):
- The King Charles Inn is ideally located in the heart of Charleston's Historic District. Beautiful guest rooms feature hand-crafted furniture, flat screen HD TVs, Free Wifi and much more. The King Charles Inn is one of the only hotels in downtown that offers COMPLIMENTARY PARKING! Join us nightly in BREW Pub for complimentary snacks and Happy Hour. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Hotels.com, Booking.com, Expedia, Orbitz, Cheap Tickets, TravelClick, Travelocity and Jetsetter so you can book your King Charles Inn reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Best Western King Charles Hotel Charleston
- Best Western Charleston
- Charleston Best Western


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Thread #109502 / / Total number of messages: 1 / Thread View Count: 332 / Add thread to favorites:
Redpainter 109502 81 50's gleaner R or A either
50's gleaner R or A
Saw this Gleaner from the 1950's in Bird City (nw) Kansas at
a fairgrounds. This type of machine, introduced in the early
50's, with it's simple and inline design gave great
competition to Massey Harris after their introduction of the
first 500 self propelled combines into the Harvest Brigade
from Texas to Montana in the 1940's.
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text: In a Big Apple heatwave in late October (28C), very unsuitably dressed, we were hot and weary walking from Downtown to Mid-Town through the Tribeca neighbourhood early afternoon. A choice of restaurants was available - I don't know why we chose South's but we were very glad we did! Friendly service, freshly prepared food - a BLT with fries and... More


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Featured property
Featured property
Featured property
£675,000 Offers in Excess of
5 Bedrooms Manor House Character Property for sale
Baynes Street, Hoddlesden, Blackburn With Darwen, Lancashire,…
Springbok properties are delighted to bring to the market this stunning manor house set on one and a half acres of land. hoddlesden hall dates back to 1861. this impressive and vast…
£160,000 Offers Over
Carus Avenue, Hoddlesden, Darwen, BB3
**a rare find ** hoddlesden** no chain** a handsome and very well presented end terrace family home, situated in the heart of the ever popular village of hoddlesden. set well back…
3 Bedrooms Terraced House for sale
Carus Avenue, Hoddlesden, Darwen
Garden fronted home for sale in the popular village of hoddlesden * large garden front * two reception rooms * kitchen * sun room * three bedrooms * family bathroom * nice rear yard/garden…
2 Bedrooms Terraced House for sale
We are so excited to bring to the property market this lovely 2 bedroom home**** set in the idyllic village of hoddlesden*** the views are amazing*** there is also an outstanding primary…
Share with your friends
Marketed by:
Ainsworth Lord Estates Ltd, Darwen
49 Market Street
Tel: See phone number 01254 760660
Website: Go to Agent Website


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30 Green St
Biddeford, ME 04005
Your advisor is here to answer questions and guide you through the buying process.
Owners.com Agent
30 Green St Biddeford, ME 04005
A spacious cape with 3 bedrooms and 1 1/2 baths. Upstairs complete refurnished. Within walking distance to shopping. A yard, deck and parking are part of this property. Occupancy would be June 3rd.
My NotesiThis is a place for you to write your thoughts and notes about this home. Only you will be able to see the notes.
- Property type: Single Family Home
- Year built: 1977
- County: York
- Cooling: #NONE
- Heating: Oil, Forced Air, Hot Water
- Parking: Driveway - Common, Driveway - Pavers, 1-4 Spaces
# of Full Bathrooms: 1 # of Half Bathrooms: 1
Garage & Parking
Parking: Driveway - Common, Driveway - Pavers, 1-4 Spaces
Lot size: 0.1100 acres | Zoning: Residential
County: York | MLS #: 1283245
Appliances: Range - Electric, Water Heater - Off Heating System
Heating & Cooling
Air Conditioning: #NONE | Heating: Oil, Forced Air, Hot Water
Utilities & Security
Sewer Service: Public | Water Source: Public
School Information
Biddeford Regional Center Of Technology
Biddeford High School
Assigned787 students 14 student/teacher
John F. Kennedy Memorial School
Assigned204 students 15 student/teacher
Biddeford Primary School
Assigned533 students 12 student/teacher
Biddeford Middle School
Assigned577 students 11 student/teacher
Biddeford Intermediate School
Assigned363 students 11 student/teacher
St James School
201 students 15 student/teacher
Saco Island School
3 students 3 student/teacher
The Master's House
29 students 7 student/teacher
Property History & Valuation
Local Insights
Listing courtesy of: Better Homes & Gardens Real Estate/The Masiello Group
Information deemed reliable but not guaranteed. All properties are subject to prior sale, change or withdrawal. Listing(s) information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Listing data is derived in whole or in part from the Maine IDX and is for consumers' personal, non- commercial use only. Dimensions are approximate and not guaranteed. All data should be independently verified. © 2017 Maine Real Estate Information System, Inc. All Rights Reserved.
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Where The Stimulus Jobs Will Be, By Congressional District
The winners and losers of Barack Obama's stimulus plan can be figured out -- to a degree -- by a new study by the White House's Council of Economic Advisors.
It breaks down by congressional district how many jobs will be created or saved by the act; the big loophole there, of course, comes from the words "or saved." It's a lot harder to quantify whether a job would have been lost without the act than it is to find a job directly created from stimulus funds.
But, for what it's worth, Texas is down for 269,000 jobs created or saved (out of a nationaide 3.5 million).
And here are the local districts, and how they fare:
Upcoming Events
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Rice Owls Men's Baseball vs. Pepperdine Waves Men's Baseball
TicketsFri., Mar. 3, 6:30pm
The big winner, somehow, is among the least-industrialized areas: the 10th District, which begins in northwest Houston and stretches out to Brenham. It's down for 10,300 jobs; maybe Blue Bell is creating an Obama flavor.
The rest:
22nd District (Sugar Land and environs) -- 9,900
7th District (Northwest Houston, West U and Bellaire) -- 9,200
2nd District (Beaumont and Liberty) -- 8,700
14th District (Galveston and Victoria) -- 8,300
9th District (Southwest Houston) -- 8,000
18th District (Central, South and North Houston) -- 7,600
29th District (Baytown and Galena Park) -- 7,300
Live in Baytown and want a stimulus job? Move to Brenham.
-- Richard Connelly
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Bibliographic Details
Title: The Complete Guide to Antiques
Publisher: Carlton Books
Publication Date: 2004
Binding: Hard Cover
Book Condition: New
Dust Jacket Condition: New
550 pages including index. Jacket protected in acid-free clear plastic cover. Bookseller Inventory # 001508
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This bookseller accepts the following methods of payment:
AbeBooks Bookseller Since: May 9, 2006
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Returns are accepted according to the Abebooks Returns Policy. We respond to all inquiries within 2 to 3 business days. Thanks for your business!
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Probably the most awkward meeting ever is now over as President Obama says that he had an "excellent conversation" with President-Elect Trump.
Pres. Obama: "I just had the opportunity to have an excellent conversation with President-elect Trump." https://t.co/tglFdQLsv9
— ABC News (@ABC) November 10, 2016
The meeting which Trump had scheduled for 10 minutes, lasted an hour-and-a-half and concluded with Obama telling reporters that "if Trump succeeds, the country succeeds."
Obama's team at the White House pic.twitter.com/H2l387pgKT
— Noga Tarnopolsky (@NTarnopolsky) November 10, 2016
"He's a very good man," is @ realDonaldTrump's only reply to shouts of questions from @WhiteHouse pool in @POTUS meeting. pic.twitter.com/xQHVt934m4
— Steve Herman (@W7VOA) November 10, 2016
When you're on a tinder date and you know you're never going to see this person again: pic.twitter.com/8skvEqUzdN
— Raul Gonzales (@RaulieGonzo) November 10, 2016
It appears the anti-trump protests outside The White House are not buying Obama's words…
"Love Trumps Hate" protesters outside the White House as President Obama meets with Prez-elect Donald Trump@nbcWashington #NBC4DC pic.twitter.com/VzLPF6sfPo
— Chris Gordon (@ChrisGordonNews) November 10, 2016


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"I had messed up that game, and I thought coaches wouldn't have much faith in me. I was nervous. I was seeing the plays, but I wouldn't react to it."
Related quotes
"Have faith in your skills. negative thoughts kill. Self-doubt can destroy our dreams before others do."
"It's not the drugs that mess up your life, it's the reason you take the drugs that mess up your life."
"If you mess up defensively, even one possession, Coach might take you out of the game. He won't do that if you take a bad shot."


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Fun Gift Dozen Golf Balls
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The fun gift dozen of novelty golf balls. Makes a great christmas holiday present or stocking stuffer. They will get laughs and enjoyment from these all year long! Great for any golf course or golf outing as a gift or prize. Copyright © 2013 B-Zany, LLC. All Rights Reserved.
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text: Turn heads as you walk on in with this stylish top! Make a lasting impression and add it to your wardrobe! You will love it the moment you try it on! This must have top features stripe pattern, scoop neck, short sleeves, open sides, draw string tie, and fitted. 50% Cotton 30% Viscose 15% Silk. 5% Elastane. Style: clothing-top-mmm4-mc-320whpinkbluebeige


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95466 Real Estate & Homes For Sale
- Property Type
- Any
- Single Family Home
- Condo/Townhouse
- Land
- 28.68 acre lot
A lovely gentle undeveloped property. Nice Redwoods, small openings, several roads, very gentle north slope land very near the ridge top. Some clearing should provide a sunny homestead. Can clear up to 3 acres with a homestead exemption. Small distant views can be opened up. Zoned TP(Timber Pro ... See More
Listing provided by Rancheria Realty
- 80.00 acre lot
TWO parcels totaling 130 Acres! This is a beautiful secluded piece of property, located in the northern hills above Philo, with south east exposure. Views of the mountains and valleys are spectacular! This property is very private and has great potential.
Listing provided by Beverly Sanders Realty Co
- 143.00 acre lot
Get away from it all at your own private wildlife retreat. Incredible views await you at this end-of-road property. 143+/- acres of ridge top above Anderson Valley. Four legal parcels to be sold as a whole. Good well. Small travel trailer included in sale. Lots of wildlife, quiet, open, rol ... See More
Listing provided by North Country Boonville
- 5 beds
- 3.00 baths
- 4.60 acre lot
- built 1940
Property includes the main house, duplex, and a large detached bonus room with finished interior. There are other outbuildings for storage and ample room for animals and gardens. Property is in a beautiful setting of trees and meadows.
Listing provided by Realty World-Selzer Realty
- 3 beds
- 2.00 baths
- 2000 sqft
- 40.00 acre lot
Charming, Tudor home, among Redwoods, with great sun exposure, sits above the beautiful Anderson Valley. 3bd/2ba home is bright and airy with large windows and open-beam, cathedral ceilings throughout. The surrounding 40 acres include lovely gardens, expansive meadows, two small ponds, a workshop ... See More
Listing provided by Big River Realty
Copyright 2016, Bay Area Real Estate Information Services, Inc. All Right Reserved.


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If you're looking for a small and unique jeweler with over 20 years experience in the bridal business than I'm the one for you! In both my studio location and on my website offer a large selection of handcrafted and individually designed rings, both engagement and wedding. I also have a wide variety of stunning bridal jewelry and gifts. I use predominantly recycled gold and only conflict free diamonds (a certification can be issued upon request).
Assisting brides through this life changing time is one of the great pleasures of my job. One of my favorite aspects of which are custom designs, working with a bride (or groom) to help find the perfect ring(s) brings me an immense sense of joy. It inspires me to pour every ounce of passion I have into these designs.
I make all of my jewelry with the bride in mind. I make it with love and I make it for life.
Copyright © 2001-2017 OneWed Inc.
All Rights Reserved.
Copyright © 2001-2017 OneWed Inc. All Rights Reserved.


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25 Free Craft Projects for Every Crafter - The Ultimate Craft Guide
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Latest Comments
"The Hushabye Shell Afghan is a beautiful blanket that would be a great shower gift. The pattern is an easy shell stitch and the colts are great for a boy or girl. I am sure that it will keep baby nice and warm. It is made with a nice four ply yarn and should work up fast. This one to save for a later date."
"The wavy rainbow baby blanket is one of the cutest that I have seen. The colors are so bright that a baby will enjoy looking at it. The blanket could also be worked up in other colors that would be great for that special little one. this is not for a beginner, so if this is your first try at crocheting you may not want to try it. Looking forward to working on this."
"The Springtime Lace Afghan Pattern is so cute. It will make a great baby blanket for that special baby. This could be made in many different colors that will really be pretty. The pattern reads really easy and a beginner could do this.I am looking forward to to this project in the very near future."
"he Cape Cod Afghan is really a cute pattern. It would be a great one for beginners. The pattern only calls for two skeins of yarn. The pattern reads really easy. This could also be used as a baby blanket and would look great in one of those baby colors. This is one pattern that I will definitely save for a later project down the road."
Fiskars Fuse
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Fiskars Fuse
Gifted by: Fiskars
Reviewed by: Latrice Murphy
We all know and love Fiskars brand for their amazing scissors and cutting tools. They have been an icon in the crafting industry for 45 years now. Now, they have taken crafting to another level for scrapbookers and cardmakers with the Fuse Creativity system.
As a crafter who does cardmaking, altered projects and scrapbooking, I was over the moon excited to get a chance to try out the Fuse and review it. I'm a sucker for gorgeous letterpress, but when I heard that this machine will die-cut and letter press all in one I just had to see it in action.
When you get this system, it comes ready to go with a started set. You will receive the machine, a die and two letterpress plates, cutting plate with rubber mat, base plate, black ink pad and the owners manual. This will let you get to playing and creating immediately. I love that you can use your own ink pad choices and colors. It's all about finding what you like best for the kind of project your creating. I was lucky enough to also receive the Adapter kit, two design sets and two expansion packs. What is all that you might ask? The design sets come with one die and two letterpress plates per pack. They are priced very well and can be stored directly in the machine itself. The expansion packs include four interchangeable letterpress plates that coordinate with the design sets. These are also priced to buy.
With all that, you can create in five different ways:
- Die cut and letterpress
- Die cut and press (like embossing)
- Just die cut
- Just press
- Just letterpress
Awesome right? The machine folds up nicely to be stored away, but I don't see why you would want to do that. I tried all five techniques and found that it cuts like butter and works like a dream. No complaints from me at all. I love how quickly you can make fun tags, cards or layout embellishments with this in one step.
I hope that you give this machine a new home in your studio. It will change the way you create for sure.
Enter to win a Fuse Creativity System Prize Pack on AllFreeChristmasCrafts.
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Feb 10, 2017
Oh my this looks like an awesome craft addition to any craft room. I am just getting into scrap booking and not familiar with a lot of thing used yet but I got my grown daughter a cricut for Christmas and she did some sayings on shirts and that is all so far. I have seen die cast machines before but did not know wether it was worth it but I see you can do a lot with it.I use the Fiskars scissors and I love them so this probably will be a good choice. Anyone use it? Would love to hear about it. Alwaysto to favecrafts review to find new things.
lmoore 6828196
Feb 09, 2013
OMG! This is at the very top of my wish list!!!! I would love to get one.
Dec 24, 2012
Kan ik ook meedoen als ik in belgi woon
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text: The keyboardist/vocalist of Chicago-based arena rock band, Styx, Dennis DeYoung continues to cultivate a successful solo career. Recording on his own as early as 1984, DeYoung produced four impressive solo albums -- Desert Moon, Back to the World, and Boomchild before reuniting briefly with his former bandmates in 1990. The reunion proved to be brief, however, and Styx disbanded a second time shortly after releasing an album, Edge of the Century. DeYoung used the opportunity t... Read more


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Why is it that some hunter count eye guards on blacktails and mule deer as points and some hunters don't. The whitetail hunters count them. Anyone want to help me out on this one.
I believe that if you can hang a ring on it, count it.!!!
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Mens Fuse T-Shirt
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Mens Fuse T-Shirt
rrp £24.99
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Colour: Multi colour
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Savant mens Fuse T-Shirt in multi. Round neck t-shirt with "Fuse" sublimation print on body with solid black sleeves and back. Finished with Savant's signature triangle back pleather branding and inside buggy detail. Front: 100% Polyester. Back and sleeves: 100% Cotton. Machine washable.
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Monday, July 12, 2010
When the Potrero branch of John Campbell's Irish Bakery opened last week, it brought along the Belfast bap, premade, wrapped in paper, and loaded into the pastry case (ask to have it nuked). The English food writer Elizabeth David called the bap the breakfast roll of Scotland. No surprise that it jumped to Northern Ireland, though its presence in the sunny Potrero lowlands, amid the carb exclusion zone around World Gym and the Design Center, might be.


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Hotfrog INDIA provides information regarding Kryfs in Mumbai Maharashtra. Kryfs is located at 3rd Floor, AZA House, 24 Turner Road Bandra W, Mumbai Maharashtra 400 050 and provides Engineering services. Contact them on +91 22 6785 9999 or by visiting them on their website http://www.kryfs.in.
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[VIDEO PICK] Lionel Messi scored his 29th La Liga goal of the season with an amazing free kick.
Messi's free kick sailed over goalkeeper Thibaut Courtois into the far top corner of the Atletico Madrid goal to give Barcelona a 2-1 win on Sunday.
Recent Soccer America Daily
Sneak Peek: FC Dallas preps for tough, early start Feb. 21, 10 p.m.
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After opening its U-20 World Cup qualifying campaign with a 1-0 loss to Panama, the USA ... Video Pick: Chicharito among Top 5 Bundesliga Golazos Feb. 21, 6:42 p.m.
Javier "Chicharito" Hernandez's fifth goal in three games for Bayer Leverkusen rates among the Bundesliga's Top ... What They're Saying: Paul Doswell Feb. 21, 6:24 p.m.
"I'm devastated, the chairman is devastated. I have spoken to Wayne and the guy is in ... Cosmos acquire Italian striker Amauri Feb. 21, 3:03 p.m.
The NASL New York Cosmos have landed 36-year-old Brazilian-born Italian striker Amauri, who scored five goals ... What They're Saying: Wayne Shaw Feb. 20, 11:52 p.m.
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The Vancouver Whitecaps will be without their two big offseason acquisitions -- Yordy Reyna and Fredy ... MLS Moves: TFC goes with TAM to sign ex-Barca midfielder Feb. 20, 10:07 p.m.
In the wake of reaching its first MLS Cup final last December, Toronto FC hasn't done ... MLS Expansion: San Diego proposes to build 'Soccer City' Feb. 20, 10:05 p.m.
In what bills itself as "America's Finest City," backers of an MLS expansion franchise plan to ... >> Soccer America Daily Archives


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Wieden+Kennedy in New York is continuing its run of tongue-in-cheek spots for "SportsCenter," showing ESPN's John Anderson and Bram Weinstein trying to figure out what recent U.S. Open winner Rafael Nadal has that attracts so many ladies. The answer, viewers find out, is a giant stash of jelly beans that he keeps in a trophy.
Full Story:Adweek/AdFreak blog


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Hi Zach, apologies for my late reply and I hope you are still in time to apply these answers to your questions for help! 1) Mythology in itself is rich in ancient culture and helps in revealing how
Hello, Typically, important historical figures have published their papers. These often provide us with original source documents about events. For example, I am working on some projects related
I'm afraid there's not much I can tell you about Janus. He was a strictly Roman god and there aren't any genealogy or stories about him. I read once he was the son of Apollo, but I can't confirm that anywhere
Dear Johnnie, if you want to oversimplified the matter, you could say that Latin - which as a Vulgar Latin (sermo vulgaris, in Latin),i.e. the idiom of the illiterate, like soldiers, merchants
Hello, First of all the reason why Latin is so complicated is not because it is a language created by pure logic instead of daily practice, as you say. This is in fact an odd statement, since all
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Stygian Abyss : this is REALLY disappointing
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Hotels in Tushemisht
Hotel reservation
Hotel rooms in Tushemisht
There are not so many hotel rooms in Tushemisht, just 7, still everyone can find an offer to suit his choice. The most common offers in this city are 3 и 4 stars, they count 4 out of 7, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the south of Tushemisht, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Tushemisht. The most populated with hotels district of Tushemisht is the north, 57% of cheap hotel rooms are concentrated here. Tushemisht is a truly multifaceted city, here everyone can find a hotel of his choice: a business person, a young couple or a family with little children. The view to lake, mountain and garden from the hotel room can serve as a pleasant addition to the journey. Apart from all these, hotels in Tushemisht offer their customers laundry service, bar, restaurant/cafe and 24 hours front desk service. Take a look at our selection of the cheap hotel rooms in Tushemisht to make a well-informed choice for your reservation!
Tushemisht cheap hotels
Guest Houses
All cheap hotels in Tushemisht
Best hotels in Tushemisht
Hotels in Tushemisht are spread around the city within the distance of 4.7 kilometers, while 3 hotels are located directly in the city center. The most popular accommodations in Tushemisht is
Hotel Millennium
, 4 stars hotel located in a 0.3 kilometers from the city center.
The best hotels are here and now. Try them!
All cities in Albania


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Email this article from PlasticsNews.com
Plastic pallet makers Cabka and Innova Packaging merge
WEIRA, GERMANY (Nov. 20, 12:25 p.m. ET) — Two European plastic pallet manufacturers — Cabka GmbH and Innova Packaging System NV — have merged under the newly-founded Cabka Group. Along with injection molding operations, Cabka has mixed plastics recycling lines as its plants in Weira, Germany; Valencia, Spain; Toronto and St. Louis.
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Bypass the box office line at many theaters with guaranteed advance tickets. If something comes up, you can return or exchange them up until the posted showtime.
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Looking for movie tickets? Enter your location to see which movie theaters are playing Cavedweller near you.
Cavedweller is an adaptation of Dorothy Allison's novel of the same name. Anne Meredith, who also adapted Allison's Bastard Out of Carolina, wrote the script, and the film was directed by Lisa Cholodenko (Laurel Canyon). Kyra Sedgwick stars as Delia Byrd. As the film opens, Delia loses her wayward rock-star husband, Randall (Kevin Bacon in a bit part), to a car accident, and decides to take her angry, heartbroken young daughter, Cissy (Regan Arnold, who played the tormented little sister in Blue Car), from Los Angeles back to her hometown in rural Georgia, where Delia left her two daughters and her abusive husband, Clint (Aidan Quinn), many years ago, to join Randall on the road. "Those people are not gonna be happy to see you," warns Delia's friend, Rosemary (singer Jill Scott in her film debut), but Delia is determined to reclaim her daughters. Cissy irrationally blames Delia for Randall's death, making the drive to Georgia an unpleasant one. Upon arriving there, Delia finds that she is not remembered fondly. Her taciturn grandfather (Myron Natwick) reluctantly takes her and Cissy in, but Delia soon learns that Clint is dying, and that her daughters, Amanda (Vanessa Zima) and Dede (April Mullen), are living with Clint's fire-and-brimstone mother (Jackie Burroughs), who has no intention of letting the girls see her. Realizing he has wronged her, Clint agrees to help Delia get custody of the girls, in exchange for her caring for him until he dies. Cavedweller was shown at the 2004 Tribeca Film Festival before premiering on Showtime. ~ Josh Ralske, Rovi


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Decorate your home with this DIY deluxe love castle.The castle is very unique and it can bring you an elegance of beauty and nobleness.It will be an focus in your home decors.Also it is a unique Christmas or birthday gift for your lover.
DIY House
The same as picture
DIY material&Instruction
1.This Product Will Be Shipped Out In Disassembly Condition and You Need To DIY The Whole Castle And It is Very challenge but very interesting.
2.This Item Includes: All The Basic Components For The House + protecting glass + Sound Control Light + 6 Implements.(glue are not included)
3.The English instruction will be shipped within the package, you can install each items according to the instruction
Due to differences in monitor settings, there may be a slight variation in color on screen,versus the actual material.
No one has consulted this product.


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Phone Reviews LeEco Le X920
Description LeEco Le X920
LeEco Le X920 - the phablet "on steroids"
How quickly we become accustomed to the large size of modern smartphones. Just a couple of years ago, and five-inch models were considered huge "shovels", which hardly fit in a pants pocket. Today, on the move you will not confidently say, is the user holding in hands the tablet or a phone. The hero of this review refers specifically to the above case.
The appearance of the novelty will not surprise the company's loyal fans. Same colors of a stylish metal housing, the same smart and ergonomic fingerprint scanner on the back panel. However, not all is that easy to the design. Significantly improve the perception of the apparatus thedual camera and reduced in comparison with those of the predecessors display bezels. The6.3-inches screen boasts of a high-resolution in 2560x1400 pixels and a lush, detailed and simply flagship image.
Such aIPS-OGS-panel is deserving and appropriate performance. The powerful Snapdragon 820 processor, 4GB of RAM and the Adreno 530 graphics accelerator are just able to provide it. Even the most graphically complex games run without a hint of lags. TheMicroSD-card slot is not provided by the developer, but its necessity is minimal due to 64GB of ROM.
22.5 and 13-megapixel rear photomodules with no doubt push the device into the ranks of cameraphones. A "SLR camera" will now lie exactly at home doing nothing, because you can take quick and easy great photos using these units. The 8-megapixel front camera also rewards the buyer with hundreds of amazing selfie. The 3400mAh battery ensures stable operation of the mobile assistant with 4-5 hours of screen time activities. Actual heavily modified Android Marshmallow, a USB Type-C port, 4G and OTG support should also be attributed to the merits of the gadget, of which it is composed in a whole. The low price also enables it to rely on millions of sales.
Buy LeEco Le X920 on Aliexprss. With the help of our service you can get best price and discount on this phone. If you whant see all deals click click here.
Specifications LeEco Le X920
|Snapdragon 820
|Adreno 530
|Android 6.0
|External memory
|Without SD slot
|6.3 inch, resolution 2560x1400 pixels
|2G (GSM): 850 / 900 / 1800 / 1900 MHz 3G (WCDMA): 850 / 900 / 2100 MHz 4G (FDD-LTE): B1(2100) / B3(1800) / B7(2600)
|Sim cards
|1 slot: nanoSIM, 2 slot: nanoSIM
|WIFI (802.11 b/g/n), Bluetooth
|Navigation (Positioning)
|Front Camera 8Mp . Rear Camera 22,5Mp . Autofocus
|Speakers and microphone
|Battery capacity
|Fingerprint's scanner
|Event indicator
|Extra feauteres
|Dual camera
Photos / Pictures LeEco Le X920
Performance LeEco Le X920
Video review LeEco Le X920Will be later
Official site LeEco Le X920
Firmware LeEco Le X920
Now we do not have stock for this smartphone, but there are similar products which you can buy at a discount, for example:
BuyLeEcoLe Max 2$191 .99
Aliexpress / DealHome
Aliexpress / Geeks Planet Store
5.7" (2560x1440) Gorilla glass / Snapdragon 820 / 4GB /64GB /21Mp Sony IMX230 /3100mAh
Colors: gray gold
See all discounted products


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Featured Videos
A WrestleMania loss can gnaw away at a Superstar for the rest of their career. These are the six most heartbreaking losses in WrestleMania history.02/16/2017 - 16:15
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Even the Cenation leader himself isn't safe from harsh criticism by the biggest names in sports-entertainment. Count down the 10 biggest disses delivered directly by Superstars to the face of John Cena.01/05/2017 - 17:15
Double the number of Superstars performing the same move on a rival means double the pain being doled out. Here are the 10 most dominant moves being executed by Superstars in 2-on-1 fashion.01/05/2017 - 17:00
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From Hollywood Rock to Sami Zayn, check out some of WWE's most infectious, under-the-radar theme songs.11/23/2016 - 12:45
Dwayne "The Rock" Johnson
Superstar Stats
Dwayne "The Rock" Johnson
Miami, Fla.
Signature Move
Rock Bottom; People's Elbow
Career Highlights
WWE Champion; Intercontinental Champion; World Tag Team Champion; 2000 Royal Rumble Match winner; WCW Champion
Dwayne "The Rock" Johnson: Bio
He has been dubbed The Great One, The People's Champion and The Most Electrifying Man in All of Entertainment.Mere words fail to capture the essence of the most charismatic Superstar of all time, though the catchphrase "boots to asses" comes awfully close.
The first third-generation Superstar in WWE history, the man born Dwayne Johnson was destined for sports-entertainment immortality since birth, but his rise to the status of a pop culture icon was harder to predict. In the time since he made his debut as a grinning good guy at the 1996 Survivor Series, The Brahma Bull has won eight WWE Championships, headlined WrestleMania, hosted "Saturday Night Live," written a New York Times bestselling autobiography, top-billed the popular HBO series "Ballers," and starred in films like "Fast Five" and "The Game Plan," which have grossed literally billions of dollars.Tthe amazing thing is, he's just getting started.
Son of WWE Hall of Famer Rocky Johnson, the University of Miami football standout showed promise early when he won the Intercontinental Championship within months of first setting foot in the ring. From there, The Rock's momentum never slowed as he laid the smackdown on "Attitude Era" rivals like "Stone Cold" Steve Austin and Triple H while spouting off endless catchphrases that immediately became part of national conversation. With one eyebrow cocked, The People's Champion would warn jabronis to "Know your role and shut your mouth" or "Just bring it!" before delivering his devastating finishing maneuver, The Rock Bottom, on the way to victory.
The 6-foot-5 competitor was soon fielding offers to star in films like "The Scorpion King" and "Gridiron Gang" thanks to the endless charisma and appeal he exuded in the squared circle. Despite a record-setting Hollywood career that included roles in the "Fast & Furious" franchises as well as "Pain & Gain," "Hercules" and "San Andreas," The Rock still returned to the ring against John Cena in the main event of WrestleMania XXVIII, won the WWE Championship from CM Punk in 2013 and defended it against Cena once again at WrestleMania 29 — all while proving to WWE's newest generation of fans what their elders already knew: That he truly is The Most Electrifying Man in All of Entertainment. If ya smellllllll …


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A majority of parents, students and staff are satisfied with the Elmbrook School District, though some frustrations were expressed in a survey reviewed Tuesday, July 16, by the school board.
The survey was distributed throughout the district to parents, students and staff. Results showed that 95 percent of parents, 89 percent of students and 86 percent of the staff in the district reported being satisfied.
The 2014 survey is in its eighth year and this year garnered its best-ever response. More than 5,000 students, 750 staff and 1,500 parents returned responses, said Chris Thompson, chief information officer for the school district, at the board meeting.
"This year was the greatest participation we've had," Thompson said.
Elmbrook students gave their teachers and schools high marks almost across the board. More than 90 percent of students believe that teachers hold high expectations for student learning and reported feeling satisfied with the curriculum and activities offered.
Another key finding showed that 86 percent of parents feel informed about important school district issues, in part due to the launch of a new website and weekly e-newsletters that were distributed during the 2013-14 school year. In addition, 88 percent of parents said the board of education and superintendent were reflecting the district's mission.
Of the staff members who responded, 91 percent said their work gives them a feeling of accomplishment, while 90 percent said their job makes good use of their skills and abilities.
But there's also room for improvement.
Half of the district's teachers said pay and benefits aren't up to par. Only 50 percent of the staff said they're satisfied with their pay, 61 percent with benefits, and 56 percent with their role in decision making.
It's not wavering their commitment, though – 100 percent said they remain committed to the district's success.
Thomas Gehl, president of the Elmbrook Board of Education, pointed out that more than one-third of the staff doesn't feel as though the school board is willing to listen to their needs. Additionally, 43 percent said they don't trust that the board will make decisions in the best interest of the children.
"That was a sobering number to me," Gehl said. "I wanted to point it out because that's the lens to which they're viewing us. I think it's important for us to keep that in mind."
A number of average responses from some parties came in at 10 percent or more below the district mean, indicating lower rates of satisfaction.
For example, students expressed a modest rate of satisfaction, at 63 percent, when asked if they liked talking to their teachers about what they're learning in class. And only 45 percent of students think they're getting enough assistance from their teachers in learning about careers related to subject areas.The survey also focused on classroom cheating.
Just 64 percent of students responded that cheating rarely occurs in class. Additionally, 57 percent of students said they were able to manage their stress level.
Thompson said the district will use these responses, along with other input, and come up with a plan of action based on the survey.
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How to Record 4K Video on iPhone 6S and iPhone 6S Plus
You'll need a new iPhone with 4K video support to have this feature available, which is the 6S or better:
1. Open the Settings app and go to "Photos & Camera".
2. Scroll down to "Camera" and tap on "Record Video".
3. Select "4K at 30 fps" to enable 4K video recording with the iPhone camera.
4. Exit out of Settings.
Now that 4K video recording is enabled, you're ready to go.


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KeyboardMaster (net.beloded.keyboardmaster) is a Mac software application that has been discovered and submitted by users of Software.com. The latest version that our users have reported running on their systems is KeyboardMaster 1.
Operating System: Mac
Default Install Path: /Applications/KeyboardMaster.app
Minimum OS version: 10.7
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