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2 Pharmaceutical Advisors –Core staff with average 20 years industry experience –Network of over 100 Advisors and growing –Covering every discipline for pharmaceutical development and commercialization –Founded in 2001, currently more than 75 clients Small and mid-sized companies Emerging pre-clinical and clinical stage companies Top 5 pharmaceutical companies Suppliers to the Life Sciences
3 The Issue We Address ClinicalADMEToxChemistry Process Development Quality Manufacturing Clinical Drug Substance Drug Product Drug Safety Formulation Project Management Everyone can pull in the various experts needed … Engineering Regulatory Marketing
4 The Issue We Address ClinicalADMEToxChemistry Process Development Quality Manufacturing Clinical Drug Substance Drug Product Drug Safety Formulation Project Management Engineering Regulatory …linking broad and deep perspective early is key to anticipating issues, accelerating progress, managing risk and… unlocking value! Marketing
5 Technology Platforms Transaction Valuation and Licensing Advisors Industry Focus Venture Capital Animal Health Suppliers to the Life Sciences Medical Devices Biotechnology Pharmaceuticals
6 Rapid, Interactive Expert Panels Rapid, Interactive Expert Panels Practical Quality Systems & Regulatory Practical Quality Systems & Regulatory Resolve Issues Build Skills Chemistry, Formulation Drug Delivery Safety & Efficacy ADME Resolve Issues Build Skills Chemistry, Formulation Drug Delivery Safety & Efficacy ADME Integrated Development View Linking CMC, Tox, Clinical Integrated Development View Linking CMC, Tox, Clinical Portfolio Decisions, Due Diligence & Valuation Portfolio Decisions, Due Diligence & Valuation Scale-up & Sourcing Decisions Scale-up & Sourcing Decisions Operational Input to Capital Plans Operational Input to Capital Plans Advisors Functional Focus Integrating Research, Development Engineering and Commercialization Expertise Click on Any Hexagon for Examples Supporting Development, Operations, Strategy and Portfolio Management
7 What Do We Do Best? Expert Content Efficient Process Professional Management What+ How= Delivery Assurance Delivery Assurance
8 Inverting the Consulting Model… Proven Delivery Insight-Driven Customized Resourcing Integrated, Experienced Functional Perspective Hands-On Problem-Solvers Cost-effective, Flexible, Independent Industry Experts ExperiencedConsultantManagers Unique Client Situation Situation
9 With Experienced Advisors… Associate Director, Venture Mgmt Asst Director for Technical Affairs Chief Executive Officer Chief Operating Officer Dept. Head of Pharmaceutical Engineering Director of Fermentation and Biocatalysis Development Director of Formulation Development Director of Pharmaceutics R&D Director of Quality Control Director of Sourcing & Planning of Chemical Development Director, Clinical Operations, Medical Affairs Director, Experimental Pathology Director, Global Medical Operations Director, Planning and Business Support, U.S. Medical and Regulatory Affairs Director, Production of Therapeutic and Diagnostic Proteins Exec Director of Manufacturing Executive Vice President, Global Drug Safety, Metabolism and Safety Pharmacology Group Director of Clinical Research Group Director of Process R&D Group Director, Preclinical Safety Assessment Manager of Organizational Effectiveness Mgr, Radiopharmaceutical Manufacturing President President of Technical Operations Senior Director Operations Planning - Worldwide Pharmaceutical Group Senior Director, North American Clinical Affairs Senior Manager, Clinical Research Senior Vice-President and Chief Scientific Officer Senior Director of Process Chemistry Senior VP of Pharmaceutical R&D Senior VP, Global Drug Development Vice President of Business Development Vice President Information Technology Vice President of Drug Development Vice President of Process Development
10 Whove Run Companies… AAI, Inc. American Cyanamid/Lederle Labs American Home Product Amylin Pharmaceuticals Applied Immune Services Arthur D. Little Astra Pharmaceuticals Aventis Axxima Pharmaceuticals AG Baxter Healthcare Corp. Benzon Pharmaceuticals BioReliance Corporation BMS Boehringer Ingelheim Boots Pharmaceuticals Bristol-Myers Squibb BSCI, Inc. Cambrian Associates Cambrex Cancer Research Center Cardinal Health Centocor Ciba-Geigy Corporation Corixa Coulter Pharmaceutical Dentsply Discovery Partners Millennium Monsanto Napp Researche Centre National Cancer Institute Neose Norcliff-Thayer Novartis Ortho Biotech PA Consulting Group Pfizer Pharmacia Response Biomedical Richardson-Vicks Salmedix Schering Corporation Schering-Plough Searle Sepracor Inc. Sigma-Aldrich Corporation SmithKline Beecham SUGEN Tektagen The Life Sciences Group Upjohn Ltd. US Environmental Protection Agency Wyeth-Ayerst Eli Lilly & Company Environmental Toxicological, Intl US FDA Center CBER & CDER FEI Technologies Fisons Fluor Daniel Genentech Genovo GSK GX BioSystems Hoechst Marion Roussel Hybridon ICI Pharmaceuticals IMBIC Immunex Immunogenetics Immunomedics IMRE Corporation Isolation Technologies J&J Knoll Pharmaceuticals, Nottingham Matthew Hall Engineering Merck Merck, Sharpe & Dohme Mettler Toledo MicroProbe Corporation
11 With Broad Functional Expertise Advisory Board s Analytical Development Analytical Methods Development/Validation Analytical Operations Biologic Manufacturing Bio-Pharmaceutical Development Bulk Active Ingredients Bulk Clinical Supply Planning Bulk Drug Substance Bulk Manufacturing Business Development Capital Raising Chemical Synthesis Chemotherapeutic Agents Clinical Pharmacology Clinical Research Clinical Supplies Mgmt & Release CMC of IND/NDAs Commercial Product Profiling Corporate Inventories Cost Evaluation/Budget Prep & Control CRO, Supplier Auditing & Mgmt Diabetes & Metabolic Diseases Documentation Drug Delivery Technology Manufacturing Materials Resource Planning New Bulk Substances Novel Formulations Oncology Clinical Research Operations Operations Research & Management Organizational Analysis Parenteral/Oral Dosage Forms Patents & Procedures Performance Audits & Validation Pharmaceutical Formulation Pharmaceutics Research Pharmacodynamics Pharmacokinetics Phase III/Commercial Needs Portfolio Management Strategies (Evaluation) Preformulation Studies Preparative Chromatography Process & Lab Automation Process and/or Equipment Validation Process Development Product Development Product Launches Product Licensing Drug Development Drug Interaction Drug Metabolism Drug Product Endocrinology & Metabolism Engineering Environmental Impact Analysis Expert Reports, Dossiers, DMFs Facility Design and/or Operation FDA Regulations & Inspections (Technical Data Pkgs.) Fermentation Filling & Packaging Operations Finance Formulation Development Good Clinical Practices Hematology & Internal Medicine Immunochemistry Research In Vitro Diagnostics In-Process Control Activities Intellectual Property Management Investments Just-In-Time Methodologies Laboratory Operations Life-Cycle Strategy Lipid Consultant Long-Term Supply Agreements Project Implementation Project Management (Multi-national) Purchasing Quality Assurance Quality Control QC Strategies & Assessment/QA Quality Systems R&D Radiolabeled Antibodies Regulatory Affairs Rx to OTC Opportunities Safety Evaluations Sales and/or Marketing Scale-Up from R&D to Manufacturing SOP Creation Start-Ups Supply Chain Synthetic & Semi-Synthetic Drug Candidates Target Identification Technology Profile Technology Transfer Toxicology-Pathology Transdermal Technology...That is Growing
12 Our Strengths to Help You HOW we support our clients –Speed & flexibility –Content expertise & general management perspective –Business decisions & technical expertise Use our approach to solve problems and address issues –The RIGHT expertise based on client needs –We efficiently identify and involve whats needed We effectively deploy and integrate the RIGHT resources –Insight about implications on other functions and processes –Multiple perspectives within a specialty where needed
13 Some Relevant Case Studies 1.Support of Critical Manufacturing Issues for a Complex Biologic 2.High Powered Expert Panel on a Deal- Breaker Issue 3.Package/ Shipping Validation to Launch Key Products
14 Recent Case Study (1) Support Critical Manufacturing Issues for a Complex Biologic The Issue Our client is a small molecule drug discovery and development company that acquired a commercially launched biologic pharmaceutical. Process variability in the fermentation of the drug was creating N-terminal variants, preventing the product from being manufactured reliably. What We Did Assembled a cross-functional team of Bio-Analytical, Fermentation, and Bio-Manufacturing experts. We supported the client through the investigation, experimentation, and implementation phases of the project by: –Assessing the process and existing data for root cause of process variability –Selecting and directing the outsourced supplier to identify weaknesses of the existing process and analytical methods supporting the process –Identifying the most likely sources of variability –Establishing vendors for new analytical methods and fermentation development –Designing and executing an experimental protocol to definitively assign root cause –Designing cost-effective scale-up plans to manufacture the revised process at scale Providing the client with: –The root cause of variability in the face of a complex web of confounding factors –A cost-effective solution to product variability, avoiding product withdrawal Protected a key source of revenue during a critical phase of growth for a young and growing Bio-Pharmaceutical Client
15 The Team John Apathy, Trained in Biochemistry and Immunology. 20 years experience developing strategies and leading pharmaceutical product development teams within a major pharmaceutical company and as senior managing consultant with a major pharmaceutical consultancy. David Dodds, PhD, Former Director of Fermentation and Bio-catalysis Development with BMS Kent Iverson, formerly with Immunex and Coulter Pharmaceuticals, has led the Process Development and Materials Management departments of all products from pre-clinical development through commercialization. John McEntire, PhD Former Corporate Vice President of BioReliance, with expertise in biopharmaceutical development analytical and formulation. Tim Noonan, PhD. Trained as a medicinal chemist, and a former VP of manufacturing, Tim has broad manufacturing, operations and quality systems experience, was instrumental in the formation of a successful contract oligonucleotide manufacturing firm. Dr. Noonan also worked as a consultant to venture capital firms performing technology due diligence.
16 Recent Case Study (2) High Powered Expert Panel on a Deal- Breaker Issue The Issue Our client identified a degredant as a known mutagen. The client needed to understand the implications for development and the value of the compound for a partner meeting. They also needed the right regulatory strategy, as well as an understanding of the trade-offs between salt forms to pursue appropriate development programs. What We Did In less than 2 weeks assembled a team that addressed their issues –2 Gentox experts that wrote the ICH guidelines –1 Gentox expert that convinced the FDA to act favorably with a similar situation –CMC expertise with polymorph expertise –Pharmacology –Tox expertise in early and late development strategies Providing the client with: –Answers to the right questions to show their partner that they had control and a plan –Awareness of questions they had not considered –Understanding of what was NOT an issue –Insight into the right development strategies to manage risk –Confidence that they had explored all the alternatives –One place to go for follow-up and coaching No one got on a plane, stayed overnight, or was wined and dined No one had to assemble and assimilate the input
17 The Team Jane S. Allen, Ph.D., D.A.B.T., former Director of Toxicology, GSK, RTP with expertise in genetic toxicology. Member of US PhRMA committee that established the ICH genetic toxicology guidelines. Michael Berman, PhD, is a former biotech CEO with broad experience in pre-clinical development for Phase I studies with a focus on biologicals and peptides as well as small molecules. Dr. Berman has taken a number of novel biologicals into Phase I. Robert L. Brent, MD, Ph.D. Distinguished Professor of Pediatrics, Radiology and Pathology and Louis and Bess Stein Professor of Pediatrics, Jefferson Medical College, Philadelphia. Former advisor to Aventis for ARAVATM, with expertise in clinical medicine related to genetic toxicology. Charles E. Piper, PhD, former Executive Director, Clinical Research Strategic Partnering, Clinical Development, and former Executive Director, Product Safety Assessment, Preclinical Development, Searle. Member of US PhRMA committee that established the ICH genetic toxicology guidelines. Thomas Crawford, PhD, former Group Director of Process R&D with Pfizer where he was responsible for the development of chemical technology and the manufacture of supplies for drug candidates from nomination to transfer to Pfizer's Global Manufacturing Group. William D. Kerns DVM, MS, DACVP former Executive Vice President, Global Drug Safety, Metabolism and Safety Pharmacology, Eisai and SmithKlineBeecham. Guy Paulus, PhD. Served most recently as Senior Vice President Drug Safety Evaluation Pfizer Central Research Groton U.S. Robert Ronfeld, Ph.D. who led Pfizers Clinical Pharmacokinetics and Pharmacodynamics group with particular expertise in Drug Metabolism and Development Strategy. Richard S. Woodward, Ph.D. Biotechnology and pharmaceutical executive with multidisciplinary international experience. Formerly with Pharmacia, Ajinomoto USA, Inc. and Quality Biotech, Inc. Tim Noonan, PhD. Trained as a medicinal chemist, and a former VP of manufacturing, Tim has broad manufacturing, operations and quality systems experience, was instrumental in the formation of a successful contract oligonucleotide manufacturing firm. Dr. Noonan also worked as a consultant to venture capital firms performing technology due diligence.
18 Recent Case Studies (3) Complex Package/ Shipping Validation to Launch Key Products The Issue Our client is extending its growth strategy requiring an enhanced capability in packaging / package design, logistics, shipping validation, quality, and management of vendors beyond current resources and internal capabilities. What We Did Assembled a cross-functional team of Logistics, Quality, Packaging and Manufacturing / Operations experts. We are supporting the client through the investigation, planning & experimentation, and implementation phases of the project by helping to determine: –when and how to utilize engineering resources from package design and testing firms vs. independent engineering resources, –the cumulative effect of expected Time /Temp excursions in the context of stability / shelf life and possible variations in packaging and logistics –where to utilize off-the-shelf secondary packaging solutions –where custom packaging solution are appropriate, trading off cost of manufacture and design with logistics and other costs. –efficiencies anywhere in the distribution chain, based on decisions in packaging or other areas –with complex, issues such as this, any key activities or decisions not assigned or staged. Providing the client with: –Roadmap for the packaging, shipping and shipping validation project, maintaining the timeline –Key program management Enabling progress in a critical area without the need to scale-up resources
19 The Team John Apathy, Trained in Biochemistry and Immunology. 20 years experience developing strategies and leading pharmaceutical product development teams within a major pharmaceutical company and as senior managing consultant with a major pharmaceutical consultancy. William Gierke, former manager of Package Development with Eli Lilly and a member of the Drug & Pharmaceutical Packaging Committee Kent Iverson, former Vice President of Manufacturing & Process Development at Corixa, Coulter and Immunex. Kent has broad operational expertise and has implemented practical solutions to complex controlled temperature shipping issues for injectables and has developed successful supply plans for numerous 2-8C products. John Pock, former head of Performance Engineering & Worldwide Quality as well as manager of International Distribution at Eli Lilly.
20 Other Recent Projects Rapid due diligence of compounds for critical decisions Manufacturing and Outsourcing strategy including determination of number of locations and in- source / outsource mix Integrated early and full drug development plans Quality Systems planning and implementation for developing company cGMP Quality System Gap Analysis for an established company Process development to address issues on a marketed product Site Audits with regulatory and practical operations perspective Manufacturing readiness assessment Sourcing - identification of sources and review / selection Candidate nomination process and portfolio review Formulation and drug delivery choices Market studies by simulating a pharma development group Deal valuation support cGMP Supplier Management
21 Why do clients look to us? Trust and confidence that we will get it done We apply world-class expertise that exactly meets the need Efficiency and effectiveness of our structured approach Avoid time consuming management and coordination of challenging resources and diverse inputs to complex issues Speed of results Accountability at a single, rather than multiple points We ensure a cross-functional and downstream view Fixed predictable budget vs. multiple experts with the meters running at different rates Delivery Assurance
22 What is keeping you up at night?
23 Practical Quality Systems & Regulatory Help What we do and how its different: Operations oriented Quality perspective, not just ex-FDA… Practical approaches to regulatory compliance Helps avoid costly reactive remedial consultants Cost-effective, proactive compliance Examples of recent projects: Establishment of appropriate cGMP systems for a research based company moving to commercial development GAP Analysis and Action Plans following FDA Warning Letter Vendor Audits that strengthen the vendor / client relationship CGMP Gap Analysis and Action Plan Pre-Approval Inspection Readiness Assessment Return / Next
24 Operational Input to Capital Plans What we do and how its different: Application of functional operations AND engineering expertise to complement client resources Helps client identify operational implications and issues with a "downstream perspective Avoids costly change orders and feature creep, and supports sound decisions, early in the process Examples of recent projects: Development of a URS ( User requirement Specification ) for $200M Small and Large Molecule development facility Future Proofing of current pharmaceutical process through process and equipment reviews Process Validation, Equipment Qualification and Operational Efficiency input to design of new vessels for aseptic processing Development of downstream processing technology requirements to meet future development needs. Return / Next
25 Resolve Issues and Build Skills What we do and how its different: Focused and efficient application of functional expertise Integrated development perspective Multi-company perspectives Access to the latest thinking Integration of inputs without costly coordination Examples of Recent Projects: Expert oversight of challenging outsourced cytotoxic fermentation Dosage form strategy and action plan to obtain IP protection Dosage form strategy to overcome half life deficiency Micro Lab productivity analysis and recommendations to improve efficiency and handle greater workload without adding staff Operational Cost Model for research stage company transitioning to a product stage company Informed Tox, CMC development and risk reduction plans to accelerate progress Return / Next
26 Rapid & Interactive Expert Panels What we do and how it s different: Expert teams, custom assembled to address critical issues Focused assignments for panel members ensure efficient process Individual and group discussions, across-functions and within functions Interactive panel discussions via telecon with the client Real, actionable answers, action plans Completed in 1-3 weeks Examples of recent projects: A rapid due diligence review of targets Implications and path forward for gen- tox issue to support out-license Review and selection of appropriate animal models Go / No-Go review of existing efficacy data Manufacturability & scalability of synthetic routes Return / Next
27 Scale-up and Sourcing Decisions What we do and how its different: Capitalize on multiple advisors experience in development, sourcing, and vendor management Rapid identification of technical requirements, identification of possible vendors, screening & qualification, support development of contracting, quality agreements etc. Drug Substance/API, Intermediates, Formulation, Drug Product, Fill-Finish Examples of Recent Projects: Identified and qualified sources for hard-to-locate emulsion capability in Europe Identified and qualified US sources of peptide manufacture for a European company API Development, Scale-Up and route filing strategy Scalability / Manufacturability review Vendor Management Strategy and Process for an emerging large Biotech Identification and Qualification of Controlled Release Drug Product manufacturers for an established Biotech Return / Next
28 Integrated Development View The Core of Advisors Approach Leverage understanding of the interrelationship between CMC, Clinical and Safety development to create and protect value Multi-company and cross-functional perspectives Insight-driven anticipation of Advisors Functional Focus issues for improved risk management Advisors who have been accountable for all aspects of development Application to specific issues and overall program management Return / Next
29 Portfolio Decisions, Due Diligence and Valuation What we do and how its different: Concurrent technical and business perspective Portfolio management decision experience across a wide range of technologies and therapeutic areas Rapid inclusion of focused subject matter expertise rather than generalist research Examples of recent projects: Due Diligence of compounds in various therapeutic areas Due Diligence of company business models Valuation of compounds in support of out-licensing decision Assembly of a Virtual Pharmaceutical Company team of users to help a supplier understand the value of their technologies resulting in successful new business strategy Return / Next
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Sorry, Thought I'd fixed that. Try again - http://s211.photobucket.com/user/Obelixx_be/library/1609%20Picton%20gardens?sort=2&page=1
New car for Xmas then Fidget. You did say the truck driver was insured?
Just back from walkies with two very excited doggies. Kittens are upstairs in splendid isolation till they get their jabs and running around chasing each other with unfairy-like paws so the doggies are still excited instead of dozing. Cosmos has bright yellow eyes at the mo cos of the drops. Bit scary. Last time I had kittens with flu they were in a dreadful state, found under a box in the street when I was a student, so I fed them Horlicks with a syringe and they survived. No need so far with Cosmos who is eating well.
I need to go and post some birthday cards and will see if the 2 for 1 offer is still going on the 70 litre bags of compost. Little reminder to OH to finish forking over the bed under the silk tree so I can get my bulbs in. Tempus fugit and all that.
T'bird - last time I looked Westminster Abbey is very expensive to visit. Seriously. What if you just need to pray?
Aster - they had some in strong purples and pinks with full flowers instead of the wishy washy half bald flowers I've seen so often. Have a look here - http://www.autumnasters.co.uk/ They also plant them in mixed borders with other plants like eupatorium and rudbeckias and have varying heights for interest. I took these pics in mid September when the display was just getting going - http://s211.photobucket.com/user/Obelixx_be/library/1609%20Picton%20gardens?sort=2&page=1
3C at midday today! Shock horror! OH was up early but says he saw no sign of frost but it must have been close. I had a lie in after a disturbed night - purry kitties and Minstrel swearing a lot at Cosmos but they're playing well this pm. Seriously unimpressed with the rescue organisation. The whole collection thing was shambolic and now it turns out Cosmos' weepy eye is cat flu so neither he nor she can have their jabs till he's better and we know she hasn't caught it. Brilliant!
Both are eating well though and full of beans so fingers crossed. I've dealt with cat flu before in street rescued kittens and they survived.
Bright and sunny so off out with the dogs after the news and a coffee.
DD stick to your guns. The agent won't get any commission at all if he doesn't sell to you and there are no other buyers in prospect.
Busy - no shop like that here and Cholet's over an hour away so I'll just have to wait till I can grow my own pak choi and greens and PSB. I have the seeds, just need the potager.
Dove - glad the neck's OK. You too Pat. Onwards and upwards.
Keep warm everyone.
It is light entertainment and was always intended to be so. What is great is that it shows people learning a skill and improving each week (mostly but not always) but, for me, the best bit is the proper dancing. OH and I love our dancing and gain much insight into choreography and technique that we can't get in our standard 30 hour season of group classes in which we learn a few new figures of all 10 dances.
These celebrities have access to 30 hours or more per week, depending on their commitment, for one dance with a personal professional teacher. Anyone who is fit and has a bit of intelligence should be able to produce a decent 90 second dance in such conditions. The differences then come from age, personality and whether or not they have a clever pro or a selfish one.
Love scallops here too but they've always had to be an Xmas treat. Still busy exploring lovely fresh fish here and haven't got to shellfish yet.
Busy - where do you find pak choi? Haven't seen any here yet and curly kale just the once in a market.
Whilst approaching Challans on the kitten run we saw whole rows of luscious fennel growing outside. Very impressive. I do like the way supermarkets here proudly display local grown veggies and fruits and cheeses and meats and misshapen or dirty but well brought up local or French fruit and veg. Still haven't found a farm shop except for pork and charcuterie but met a man from a local cheese co-operative yesterday ad some local fish smokers.
We now have gas so I have just resumed the cooking of cod with clementines for dinner.
It has been a beautiful, sunny day with clear skies and little wind. We've been treated to fabulous starry skies for the last two nights.
We have just got in from a marathon kitten fest. Drove to Machecoul to fetch 3 kittens and deposit 2 en route home at a flat in La Roche-S-Y except I hadn't banked on over an hour at the vet's waiting for each one to be prodded, poked, given its ID chip, weighed and checked for fleas. Ours is the little black and white 4 month old who we're calling Minstrel after a dianthus I lust after. She was found under a vehicle and covered in motor oil nearly 3 weeks ago and has had to be cleaned up and settled. She's very cuddly and is now upstairs getting to know Cosmos after a good feed.
T'other pair are a gorgeous tabby female of about 7 months and her brother who is the most beautiful taupe and cream subtly striped tabby with dark brown seal points and blue eyes. Stunning and also very cuddly but we must be sensible sometimes.
Vet tomorrow for jabs and an ID chip for Cosmos.
Busy - thanks for that link. We have two levels behind the house with a bank that separates them. We could probably excavate a bit further to put an above ground pool whose top would then be level with the upper layer with a bit of decking at the join. On the lower level, there are 3 concrete posts with wires stretched between for washing but which we don't use as I am planning to add extra levels of wire and grow clems and roses so they could hide a pool. Priorities are a proper potager, a new kitchen and another shower room. Then we can talk pools - as long as it's heated by solar panels. I do not do cold water and he's not having a private pool. There's a cold water ocean just down the road.
Hosta , being a devout atheist brought up by Plymouth Brethren style Methodists, I have a deep mistrust of anything decided on "faith". I much prefer a sound moral basis and logic plus an understanding of consequences to decide policy. Just imagine how much more peaceful the world would be with no religion and a respect for one another's differences instead of fear and hatred or contempt.
HI Frank. Nice to see you.
Samba is my least favourite dance to do cos of all that rotation in the hips and the leg technique to achieve it. Really difficult and, since I have my new feet, hard on the toes to get all the bounce. Oti's tribal take on it was very clever and more interesting than the usual party spin with tail feathers. It was fabulous and Danny danced it with aplomb.
Louise has come on leaps and bounds and I really like her. Used to think she was vapid on Sunday Brunch but Strictly has brought out her warmth and she's turned out to be a good dancer too.
I forgot forsythia and flowering currant, especially hen planted together.
Love roses but most do need to be planted with other stuff to hide their legs and I don't see the point of once flowering shrubs and those with no perfume.
I used to dislike Michaelmas daisies till we went to Picton Gardens in September and found some really lovely ones. Far too many have faded looking teeny starry flowers that look like a weed that proliferates here and then there's all that bovver with mildew.
Having seen a majestic gnnera at Keukenhof and also Beth CHatto's garden I will be planting one here - once the pond edges have been cleared of all the brambles and bullrush which brings me to iris pseudacorus - nasty thug with terraforming ambitions. Hate it for wrecking my pond in Belgium..
It would help to give it all a thoroughly good soaking before you start. Gallons of water and then let it soak overnight and it will be easier to prise up, working in from the edges.

subset: commoncrawl


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1986 mazda b2000 for sale on US's largest classifieds sites (45 results)
1986 Mazda B2000 manual
1986 Mazda B2000 manual, New Head Gasket, timing Belts, V-Belt, water pump, cap/rotor, pads, rear shoes, head lamp, wipers, oil change, thermostat, kemp sensor, flush radiator $ 2,200 obo
1986 Mazda B2000
Scammers don't bother, I've already heard enough of your stupid crapRuns and drives good and very reliable. Tag and title up to date. Carburetor, timing belt, water pump and radiator have all been replaced in the last two years.
1986 Mazda B2000 LX
1986 Mazda B2000 LX, 4 Cylinder, 5 Speed, Cold A/C & Hot Heater, Good Tires, Top of Engine Rebuilt including: New Head, Valves, Cam, Rocker Assembly etc. New Radiator, New Radiator Hoses, New Water Pump & Thermostat. Also New Timing Belt, Spark Plugs & Fresh Oil Change. Have Receipts for all. Toolbox ...
Mazda B2000 Pick Up, Long Bed 1986
Mazda B2000, 1986, Pick Up, Long bed with canopy. Runs well and mechanically maintained. 186,000 easy miles. 5 Speed, Manual. Very reliable, easy to service and simple to work on.
1986 mazda b2000
I have a 1986 mazda b2000 2wd 5speed. It\'s a good little pickup, it has a new clutch, new carb, new exhaust and has a nice stereo and decent interior. It gets great mpg. It has 112k miles. I also have another set of snow tires and rims for the pickup
1986 Mazda B2000
No motor just body asking $1100 or best offer body is in fair condition
1986 mazda b2000
need to get rid of it asap just asking for $1800 O.B.O it\'s a great truck no dents minor scratches runs great never broke down on me really reliable no oil leaks clean motor maintenance was always done it only has 154k Miles original motor
1986 Mazda B2000
1986 mazda b2000condition: faircylinders: 4 cylindersdrive: rwdfuel: gasodometer: 130123paint color: bluetitle status: cleantransmission: manualtype: pickupI have for sale a 1986 Mazda B-2000 2x4 8 ft bed pick up truck. It\'s a 2.0 liter 4 cylinder with
1986 Mazda b2000
Selling my 1986 Mazda b2000 pickup just put lots of new parts brand new head gasket and my mechanic did something wrong sometime it\'s start and sometime doesn\'t my buddy told my it could be carburetor but I don\'t have time to fix it work a lot and yes frim at 1500 have more then that in truck any q...
1986 Mazda b2000
Selling my 1986 Mazda b2000 pickup just put lots of new parts brand new head gasket and my mechanic did something wrong sometime it\'s start and sometime doesn\'t my buddy told my it could be carburetor but I don\'t have time to fix it work a lot and yes frim at 1500 have more then that in truck any q...
1986 Mazda B2000
If you seeing this ad, I still have the truck, no need to ask me if I do still have it. Here I have special rare custom truck 1986 Mazda B2000 diesel 2.0L RF-Turbo 4 CYL. Reg Cab, Long Bed, with inner plastic bed and lumber rack. The miles approx is 90K on engine and 2K on trans
mazda b2000 1986
Mazda Truck needs work!! Starts up and runs but bushing in gear shift went bad!! Minor work but decent truck!!434threesixthree0three5nine...open to trades for fourwheeler or dirtbikes!!
1986 Mazda B2000
1986 Mazda b2000 with 170k miles. Runs and drives. Gets 25-27 MPG. New radiator, hoses, thermostat, waterpump and head gasket. There is a few small dents in the rear but overall good body. Interior has a burn by the drivers seat in the carpet. Tires are weather cracked and need replaced. Comes with 5 ...
1986 Mazda B2000 PU - $1995 (Jacksonville)
Great little Truck R U looking for a gtreat Little Truck R U looking for a Truck that get great milege I have a 1986 Mazda`B2000 4 cyl-----5spd ------get over 27 MPG Excellent running older Truck Price is $1995 Give me a call at 904-554-9757 ...
Year: 1986, Make: Jac
1986 mazda b2000 $950 obo - $950 (san antonio)
it is a 1986 mazda b2000 ., not a 2006........... it runs good but shuts off on idle dont know what is wrong and i dont care if you do its your for 950 or best offer., call me if you need directions to pick it up otherwise dont call ., clean titile in hand , reg. and insp. 210-248-7027 jose ...
(sold!)1986 Mazda B2000 (reduced again) - $450 (wichita falls)
This truck began as my project truck, and after $1.000 in new parts ranging from ball joints and tie rod ends, to timing belt and water pump the carb now needs rebuilt or replaced. The brakes worked fine too as the pads rotors and brake master cylinder were new until an "auto" shop on "sheppard" towe...
1986 Mazda B2000 CLEAN!! - $3000 (Shelton)
1986 Mazda B2000, 5-speed with only 117,000 miles! Just did a tune up and i just recently replaced the starter. Truck has a cherry bomb (glass pack) for exhaust which is kicked out in front of the left rear tire. Truck is wired for subs and an amp, subs and 6x9`s are not included. I will include a son...
1986 mazda b2000 - $1150 (ravensdale)
Run drives very well 1150$ smokes a little needs valves seals put in have them. no emissions needed Hard to find gage`s w/tack. This is a good truck that could be real grate its strait & clean New timing belt water pump thermostat head gasket/ most all gaskets oil change air fi...
1986 Mazda B2000 - $1700 (Enumclaw)
I have for sale a 1986 Mazda b 2000. The truck is a base model comes with factory working am/fm cassette player. The truck has about 90k on motor. Has a 5 speed transmission. The truck runs great. It has some minor dents in the front drivers side fender, other than that the body is pretty good. the pa...
1986 mazda b2000 - $1200 (mountain home)
I am sellin my 86 mazda pickup,great condition runs great good on gas.. has 173ooo miles on it if interested give me a call at 208 969 0261 thanks. Location: mountain home it`s NOT ok to contact this poster with services or other commercial interests


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Blog Entry# 2054569
Posted: Nov 10 2016 (10:14)
No Responses Yet
Journey: Fri Nov 11, 2016 @ 23:2712296/Sanghamitra SF Express (PT)
Class: AC 3-tier - 3A | Tot Seats: Avbl 7
Travel: MGS/Mughal Sarai Junction to BZA/Vijayawada Junction | 1705 km / 2703 km
Entry# 2054569
PNR: 615-xxxxxxx | Similar PNRs
Posted Status as of: Nov 10 2016 (10:14)Passenger 1: Waitlist# 19 (Booking Status: W/L 36,CK)
Total Fare: 2195
Chart NOT Prepared
Please analyze this PNR, and predict the final Charting Status. Thanks.
Latest Status as of: Nov 11 2016 (23:25)Passenger 1: B3,4 [LB]/Coach Position:8 (Booking Status: W/L 36,CK)
Total Fare: 2195
Chart PREPARED
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CHARLOTTE, N.C. (AP) Carolina Panthers running back DeAngelo Williams (FSY) is doubtful for Sunday's game against the New York Giants after missing his third straight practice with a sprained left ankle.
Reserve running back Tyrell Sutton (FSY) is also doubtful after sitting out Friday with a calf injury.
OTHER INJURIES: Delhomme out for season
Williams was injured in the first quarter of last Sunday's win over Minnesota and didn't return. Jonathan Stewart (FSY) replaced him and rushed for 109 yards and a touchdown.
Stewart is questionable with a sore left Achilles' tendon, but practiced Friday.
Quarterback Matt Moore (FSY) (shoulder) and cornerback Richard Marshall (FSY) (ankle) are also questionable.
Both practiced Friday in a workout that took place on the Bank of America Stadium concourse because of heavy rain.
Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Like "For Dummies" books, you can read this in whatever order you choose and learn about mobility and BYOD; and how to put a competitive mobile infrastructure in place. Developed for SMBs and large enterprises alike, you will find helpful use cases, planning, and implementation.
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Our Dev teams are like yours. They're continually cranking out code for new features/bugs fixes, testing, deploying, testing some more, responding to production monitoring events and more. It's complex. So, we thought you'd like to see what's working for us.
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Miami-South Florida Culinary Events
February 22-26, 2017
Foodies, wine connoisseurs, world-famous chefs and celebrities convene for the South Beach Food & Wine Festival. Participate in wine seminars, grand tastings, book signings, demos, late-night parties, brunches and lunches hosted by Martha Stewart, Gabrielle Hamilton, Nobu Matsuhisa and many more. For more information, visit the official website
May 12
Taste of the Nation for No Kid Hungry will hold its South Florida fundraiser at Soho Studios (2136 NW 1st Ave., Miami). Enjoy food and drinks from more than 50 chefs and bartenders. The cost is $125 for general admission (7 p.m.-10 p.m.) and $200 for VIP plus after-party admission (6 p.m.-12 a.m.). For more information, visit the official website
Edge Steak & Bar offers happy hour from daily from 4 p.m.-7 p.m. Specials include two-for-one small bites from the bar menu, $1 oysters and half off draft beer, some wines and well and specialty cocktails. Edge Steak & Bar, Four Seasons Hotel Miami, 1435 Brickell Ave., 7th floor, Miami, FL 33131, 305-381-3190 .
The Mai Kai in Fort Lauderdale offers happy hour in the Molokai Bar from opening to 7 p.m. Tues.-Sun. Guests can enjoy half off appetizers and drinks (excluding bottles of wine, champagne, Sidewinder's Fang and the Mystery Drink). Mai Kai, 3599 N. Federal Hwy., Fort Lauderdale, FL 33308, 954-563-3272.
Weekdays from 5 p.m.-8 p.m., db bistro moderne offers happy hour featuring $1 oysters (5 p.m.-7 p.m.), $3 nibbles (stuffed dates, crispy pork belly, etc.) and specially priced beers, wine by the glass and cocktails. db bistro moderne, JW Marriott Marquis Miami, 255 Biscayne Blvd. Way, Miami, FL 33131, 305-421-8800.
Monday through Friday
Sugarcane Raw Bar Grill offers happy hour at the bar from 4 p.m.-7 p.m. Monday-Friday. Signature cocktails are $7, pitchers of beer or sangria cost $25 and bar bites (tapas, raw bar items, sushi rolls, etc.) run $3-12. Sugarcane Raw Bar Grill, Midtown Miami, 3252 NE First Ave., Miami, FL 33137, 786-369-0353.
Find out which restaurants and chefs top the list of GAYOT's 2016 Annual Restaurant Awards.


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Government told to delete DNA records of innocent people
The Ethics Group, a government advisory body, says DNA samples of those not convicted of a crime should be deleted from the police...
This Article Covers
Legislation & regulation
The Ethics Group, a government advisory body, says DNA samples of those not convicted of a crime should be deleted from the police National DNA Database.
Brexit and UK tech: Essential guide
Find your way in the post-Brexit world and establish priorities in the face of uncertainty
By submitting your personal information, you agree that TechTarget and its partners may contact you regarding relevant content, products and special offers.
You also agree that your personal information may be transferred and processed in the United States, and that you have read and agree to the Terms of Use and the Privacy Policy.
The current database contains 4.2m records, and these are never deleted, even if a person is never charged with an offence.
It is estimated up to 500,000 people who have profiles on the database have not been convicted or cautioned for a crime.
This number includes profiles of up to 100,000 children.
In its first annual report, The Ethics Group said there should be a straightforward system for innocent people to have their DNA records deleted.
It also rejected police demands for a national DNA database.
The government said it would respond to the report in the autumn, after consulting with the police.
NA database:
Police to reopen 4,000 cold cases with DNA database >>
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JOB SUMMARY: This position is accountable for providing competent nursing care for patients with common health problems, and is expected to deliver competent patient care to a full patient assignment. This position practices under the direction of the designated nurse executive, within the scope of the Nursing Practice Act, and in accordance with Children's polices.
REQUIREMENTS: This position requires: A) a graduate from an accredited nursing program. BSN strongly preferred; B) an active California Registered Nurse licensure (RN); C) Life Support Certifications (see specifics below); and D) experience to correlate with Clinical Ladder level. Bilingual skills desirable.
Life Support Certifications Required:1) HeartCode Basic Life Support (BLS) within 30 days; 2) Adv Neonatal Resuscitation Program (NRP) within 6 months: Merced MNN and NICU
POSITION DETAILS: Full time 69 hours per pay period with shift still being determined.


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St Louis would totally be that cool aunt everyone has! Although the city is older, it still has an edgy funk to it! You can never have a dull time in St. Louis.Discover More
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Chicago is such a big city that it easily caters to people with different tastes and interests. There is no shortage of various world-class restaurants and during the summers there are actually several festivals and events every single week.Discover More
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WILDEARTH'S Djuma Cam Discussion - Tuesday, August 21, 2007
145 posts / 0 new
Tue, 21/08/2007 - 12:49am#1
WILDEARTH'S Djuma Cam Discussion - Tuesday, August 21, 2007
Wed, 22/08/2007 - 12:40am#2
No...guess I missed those...I just turned my puter on a little while ago...I just started a new day
Wed, 22/08/2007 - 12:37am#3
I didn't see that Lana but I did see something small on this side a while ago...did you see the lions and rhino at NK?
Wed, 22/08/2007 - 12:28am#4
I think I just saw a lion walking on the backside of the wh
Tue, 21/08/2007 - 10:11pm#5
Helloooooo empty thread!
I feel like a proper amateur asking this, but:
As for the cackling sound... I am clueless.
Sad to read I missed the lion roaring!
Tue, 21/08/2007 - 8:22pm#6
I wish Mike had been on an listening. I missed the first call but later ones were quite confusing. Didn't help that my cam was buffering too. First I thought lion, then buff, then hippo, then... I don't know what I was hearing. LOL
Tue, 21/08/2007 - 7:55pm#7
that what i thought it sound like a lion to me also.
Tue, 21/08/2007 - 7:53pm#8
Hi AJ,
At first I thought it was a leopard because I heard the sawing noise. Now it's sounding more like a lion...
Tue, 21/08/2007 - 7:50pm#9
hello, is that a lion or a leopard that i am hearing?
Tue, 21/08/2007 - 7:33pm#10
Thanks Lea, lets just assume you will not become ill again!
Tue, 21/08/2007 - 6:55pm#11
Thanks Mike--You are full knowledge. Just in case I might become ill again I did not want to miss the chance to say I hope you have a great time in SA. You will be missed.


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Max & Cleo
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Full profile →'">
The author is a Forbes contributor. The opinions expressed are those of the writer.
In trading on Thursday, shares of Great Southern Bancorp, Inc. (NASD: GSBC) crossed below their 200 day moving average of $26.25, changing hands as low as $26.00 per share. Great Southern Bancorp, Inc. shares are currently trading down about 2.6% on the day. The chart below shows the one year performance of GSBC shares, versus its 200 day moving average:
Click here to find out which 9 other stocks recently crossed below their 200 day moving average »
Looking at the chart above, GSBC's low point in its 52 week range is $18.17 per share, with $31.81 as the 52 week high point — that compares with a last trade of $26.03.
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According to the ETF Finder at ETF Channel, GSBC makes up 2.44% of the Dynamic Banking Portfolio ETF (AMEX: PJB)which is trading lower by about 2.3% on the day Thursday.
See what other ETFs contain GSBC »


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Lashkar man shot dead in Mohmand
GHALLANAI: A pro–government peace committee member was killed and another was kidnapped in two different incidents in Mohmand Agency on Thursday, local sources said. The sources said that unidentified armed men opened fire on Kamil Shah, a member of the anti-militants peace committee in Chamar-kand area in Safi tehsil. The sources said Kamil Shah sustained several bullet injuries and died on the spot. Meanwhile, unidentified armed men kidnapped Ali Haider, a member of the peace committee in Dawezai area in Pindyali tehsil.
Sajjad Mohmand, spokes-person for the Tehrik-e-Taliban Pakistan, Mohmand Agency chapter, claimed responsibility for both incidents.
The sources said that four persons including two children were injured when a shell fired from an unknown location hit the house of one Sabz Ali in Qandaharo in Safi tehsil. Unconfirmed reports said that one person was killed in the incident and four others sustained injuries.
Also, suspected militants blew up a power pylon in Ghazi Kor in Halimzai tehsil. The political administration arrested 11 persons under the collective responsibility clause of the Frontier Crimes Regulations (FCR) as they had failed to prevent the incident in their area.
The complete article can be found at The News.


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Ronnie B.
Report | 5 years ago
Great course, very helpful staff! Keep doing what you do so well.
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Jump from one hole to another at Clinton's Timberlake Golf Club, NC, as you hone in your golfing skills. Make your next outing a hole in one when you bring your family or friends to Timberlake Golf Club for a relaxing game of golf.
Timberlake Golf Club in Clinton provides an array of golf course options for golfers of all skill levels, including pro and beginner. These classes feature a wide range of techniques to help you strengthen your body.
Easy parking is accessible for Timberlake Golf Club's customers. The golf course at Timberlake Golf Club in Clinton are calling your name so head on over today and enjoy a game of golf.


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About the Show
Actor Omar Miller and fashion designer Andres Izquieta of Five Four Clothing know that the best travel experiences don't come from following a schedule—they come from following advice. And a good Wifi connection. In each episode of WEEKEND FIX, Omar and Andres travel to a different city, using every social networking tool at their fingertips to seek out recommendations from friends, locals, and strangers alike for the go-to hotels, off-the-radar restaurants and can't-miss local experiences that the guidebooks just can't tell you about.
Weekend Fix: Time to Finish the Challah - Bonus ScenePosted on 12/4/2014
Omar and Andres return to Hof Kelsten to finish baking their challah bread with Jeffrey Finkelstein in this bonus scene from Montreal.
EPISODE 6 of 6
Season 1, Episode 6 OLDER EPISODE | NEWER EPISODE
MONTREALAirdate: 12/3/2014 | Production Credits Omar and Andres try urban beekeeping before playing street hockey with two NHL legends: former Montreal Canadiens Sergio Momesso and Stephane Richer.
Cast & Crew
Omar Benson Miller
Andres Izquieta
Omar Benson Miller
Andres Izquieta


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International Youth Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TravelPod Member ReviewsInternational Youth Hotel Salzburg
good location between train station and old town, perfectly adequate hostel with comfortable beds, beautiful hardwood floors, clean bathrooms, spacious 6-bed dorms, helpful front desk, meals can be purchased, excellent duvets. The only real complaint we have is with the kitchen. It's supposedly newly-renovated, but it's tiny, ill-equipped, and hiding downstairs (in the dungeon - no sunlight). It only has a tiny half-fridge for food storage... and there are about 180 beds at the hostel!
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews International Youth Hotel Salzburg
Travel Blogs from Salzburg
A boat trip on a beautiful lake
... water. The boats on the lake are all electric to preserve the cleanliness and peacefulness of the area. At one point on the trip the guide gets his trumpet out, and plays a tune next to the cliffside called the Echowand, and depending on the weather the notes echo one or two times - all very funky ...
Austrian Alps
... br>
A million fallen leaves, a cliff face and many rose prickles later Brendan found himself body surfing down towards the gorge legs first. An anxious couple of seconds followed as he struggled up the muddy mountain back to relative safety. Deciding we were not to leave empty handed ...
Oh Yeah, The Hills Were Alive
... down the mountain on out luge boards and Seana got a nice video of her trip down. I really can't even put into words how unbelievable Austria is once you get out of the towns and into the mountains. As we rode around in our bus with The Von Trapp Orchestra blaring over the speakers, you look to your left and right and all that you see is rolling green fields tucked between these enormous mountains with cows everywhere. Every angle you look at looks like it belongs on a ...
Bled - our home away from home.
... tickets, then met špela and Denis back at the hostel.
We said a sad farewell to špela, as she had to go and clean the rooms, then Denis drove us to the train station. After nearly missing our train, we then held it up so Denis could run after us for a big hug goodbye. Then we were on the train, headed to Austria, feeling very sad to leave.
We both loved Bled, made some great friends there, and cant wait to go back there one day... Maybe next ...
The City of Salt...
... complete with Trick Fountains, look at some classic cars, go in a cable car up the Untersberg Mountain, visit Burchestgaden, Eagle's Nest, Konigsee and take a cruise up the Konigsee river..... So if that looks like a long sentence it's because it is, and I'm exhausted. I will now attempt to descibe these experiences in a little more detail so for those of you who are just sick of reading about our trip and wish that those annoying littlle blog ...
Other places to stay in Salzburg
Wyndham Grand Salzburg Conference CenterFanny-von-Lehnert-Strasse 7, Salzburg | 4 star hotelfrom $119
- Ok location
- Nice Hotel-don't like the location
- Fantastic.... Great Reception Staff & Room Service
Crowne Plaza Hotel Salzburg - The PitterRainerstrasse 6, Salzburg | 3 star hotelfrom $129
- Perfect for us
- A restful place
- Good value for money - its got a gym and pool!
NH Salzburg CityFranz-Josef-Strasse 26, Salzburg | 4 star hotelfrom $110
- Great hotel & location
- Was very good for the price
- Good hotel, lousy service
Sheraton SalzburgAuerspergstrasse 4, Salzburg | 5 star hotelfrom $215
- Great Hotel
- Great Hotel, Great Service
- Beautiful friendly hotel
Castellani ParkhotelAlpenstrasse 6, Salzburg | 4 star hotelfrom $156
- Great hotel in a great city!
- Modern Classic
- Best Western Castellani Parkhotel
Austria Trend Hotel Europa SalzburgRainerstrasse 31, Salzburg | 4 star hotelfrom $113
- Air Conditioning
Ramada Hotel Salzburg City CentreSuedtiroler Platz 13, Salzburg | 4 star hotelfrom $119
Mercure Salzburg CityBayerhamerstrasse 14/A, Salzburg | 4 star hotelfrom $94
Mercure Salzburg CentralSterneckstrasse 20, Salzburg | 4 star hotelfrom $105
Hotel Sacher SalzburgSchwarzstrasse 5 - 7, Salzburg | 5 star hotelfrom $265
- Sacher tarte und Cognac
- This is what they mean by …
- Satisfied
Hotel NeutorNeutorstrasse 8, Salzburg | 3 star hotelfrom $95
Star Inn Hotel Salzburg AirportFranz-Broetzner-Strasse 15, Salzburg | 3 star hotelfrom $86
Austria Trend Hotel Salzburg MitteMuenchner Bundesstrasse 114a, Salzburg | 4 star hotelfrom $86
- Good clean stay
- Comfortable Stay
Parkhotel BrunauerElisabethstrasse 45A, Salzburg | 4 star hotelfrom $129
Ibis Salzburg NordCarl-Zuckmayer-Strasse 1, Salzburg | 3 star hotelfrom $68
Hotel Goldener Hirsch, a Luxury Collection Hotel, SalzburgGetreidegasse 37, Salzburg | 5 star hotelfrom $258
- The
- A wonderful haven after a …
- Goldener Hirsch
ACHAT Plaza Zum HirschenSaint-Julien-Strasse 21-23, Salzburg | 4 star hotelfrom $98
- Location by Train Station
- Loved this Hotel
- Great location, breakfast & staff
Star Inn Hotel Salzburg Zentrum, by ComfortHildmannplatz 5, Salzburg | 3 star hotelfrom $111
- Good Location, Friendly St…
- Cheap & Good Hotel
Hotel&Villa AuerspergAuerspergstrasse 61, Salzburg | 4 star hotelfrom $216
- Great Hotel
- Nice hotel, a little out of the way
- Luxury for reasonable price!
Hotel Hofwirt SalzburgSchallmooser Hauptstrasse 1, Salzburg | 3 star hotelfrom $120
- Good location for a good p…
- Clean hotel, friendly/help…
Hotel am MirabellplatzParis-Lodron-Strasse 1, Salzburg | 3 star hotelfrom $126
- Good Stay in Salzburg
- Excellent stay,good price
- Lovely Stay
Hotel SteinGiselakai 3-5, Salzburg | 4 star hotelfrom $170
- 8/10...could have been 10..
- The best Hotel in Salzburg!
- Wouldn't stay here again
Stadtkrug HotelLinzer Gasse 20, Salzburg | 4 star hotelfrom $161
- Wonderful Hotel Run by Won…
Hotel zur PostMaxglaner Hauptstrasse 45, Salzburg | 3 star hotelfrom $132
Amadeo HotelAlpenstrasse 115-117, Salzburg | 2 star hotelfrom $114
HartlwirtLieferinger Hauptstrasse 120, Salzburg | 3 star hotelfrom $120


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20th Century Italian Coffee Table In Louis XVI Style
c. 1940 Italy
Offered by Parino Mercato Antiquario
SoldRequest Information Call Dealer Favourite Item
Elegant Italian coffee table of the 20th century. Furniture made by ornately carved, painted and gilded wood of great quality and good taste. Living room coffee table in Louis XVI style with not original mirror top, replaced during the 20th century. Furniture of pleasant decor and excellent proportions, of good service. It has some small wooden decor deficiencies in the capitals and flowers garlands. Overall in fairly conservative state.
It has some small wooden decor deficiencies in the capitals and flowers garlands. Overall in fairly conservative state.
|62.00 cm
|(24.41 inches)
|95.00 cm
|(37.40 inches)
|56.00 cm
|(22.05 inches)
Stock Code6272
MediumWood, Mirror
Parino Mercato Antiquario
Parino Mercato Antiquario
Strada Statale 28
Regione Olle
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Perfect for weddings, birthdays, or other big events, Venue 929 has everything you need to plan a party and house hundreds of guests. There's even a pond outside that's perfect for taking beautiful photos, so consider this spot for your celebration:
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PAID VALUE EXPIRES ON February 27, 2022
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Liberal Opinion Week
One of the most important questions for analyzing a potential Supreme Court justice is how he or she understands economic and political power: Who should govern? How should power be distributed in a society? In the case of Neil Gorsuch, the federal appeals judge President Trump has nominated for the high court, the answers are troubling. Gorsuch's record on the bench reveals a man with a strong top-down streak, a preference for concentrated wealth and power. He has consistently been the friend of big business and monopolies at the expense of competition and open markets, and the friend of big donors at the expense of small donors. In disputes between the employee and employer, he sides with the boss.
How judges interpret antitrust law is especially important in understanding their approach to the relationship between economic and political power. It tells you a lot about what they think counts as fair and free competition between citizens. It also teaches us whether they understand markets as institutions -- formed through rules and subject to public governance -- or instead as some mythic set of natural forces, beyond our control.
Full text and e-editions are available to premium subscribers only. To subscribe to the digital edition, please visit subscription page. If you are already a subscriber, please login to the site.
We'd be happy to set up login information for a free week of the Liberal Opinion Week website for you. Please email email@example.com with your request. Thanks for your interest in the Liberal!
I was 7 when my family moved to Texas. I didn't have much say in the matter - my parents decided it would be the best place for me and my sisters to grow up, so we built our lives there.
I went to school, made friends, studied hard and earned admission to the University of Houston. I worked my way through college and began my career in Texas, a place that had long since become my home.
Those memories arise every time I meet students enrolled in the federal program called Deferred Action for Childhood Arrivals. These young people were brought to the United States as children, carried along through no decision of their own. They have grown up American - studying and learning in our public schools, celebrating our national holidays, becoming a part of our communities. They've made a lifetime of friends and memories here. This is the only home most of them can remember.
If you halved Donald Trump's age, changed his sexual orientation, gave him a British accent and fussed with his hair only a little, you'd end up with a creature much like Milo Yiannopoulos.
He could be Trump's lost gay child. In fact, Yiannopoulos, 33, has a habit of referring to Trump, 70, as "Daddy."
Trump the father and Yiannopoulos the son are both provocateurs who realize that in this day and age especially, the currency of celebrity isn't demeaned by the outrageousness and offensiveness through which a person achieves it.
Both are con men, wrapping themselves in higher causes, though their primary agendas are the advancement of themselves.
Both believe that audience size equals value — and that having people listen to you is the same as having something worthwhile to say.
I heard nothing worthwhile during Yiannopoulos' news conference Tuesday afternoon, though I heard a whole lot of Trump in him, and I wondered — no, shuddered — at a kind of worldview that may well be in ascendance, thanks to its validation by our president.
It should be clear by now that there are five different Trump administrations swirling before our eyes — Trump Entertainment, Trump Cleanup, Trump Crazy, Trump GOP and the Essential Trump — and no one can predict which will define this presidency, let alone make a success of it.
Trump Entertainment shows up every day now in the form of an outrageous "alternative fact," a pugnacious news conference, a tweet denouncing the news media as "the enemy of the American people" — or as a pep rally in Florida, unconnected to any particular legislative agenda and organized entirely for the purpose of giving the president an ego sugar high.
The country, though, is getting addicted to Trump Entertainment. It is hard to avert your gaze from a president who will say anything about anything. It's so unusual, like a flying elephant or a horse that can talk, that you can't help but stare. But it's such a waste of energy. I wonder if the Chinese are spending their days this way. I suspect they've added another high-speed rail line just since Trump's election.
Nearly 15 years ago, I informed my skeptical father that I was pursuing a job with the Central Intelligence Agency. Among his many concerns was that others would never believe I had resigned from the agency when I sought my next job. "Once CIA, always CIA," he said. But that didn't give me pause. This wouldn't be just my first real job, I thought then; it would be my career.
That changed when I formally resigned last week. Despite working proudly for Republican and Democratic presidents, I reluctantly concluded that I cannot in good faith serve this administration as an intelligence professional.
This was not a decision I made lightly. I sought out the CIA as a college student, convinced that it was the ideal place to serve my country and put an otherwise abstract international-relations degree to use. I wasn't disappointed.
With cries of "fake news" coming from all sides, schools are stepping up - teaching media literacy to help students distinguish rumor from fact, hoax from reality.
As President Donald Trump's bizarre suggestion of a recent terrorist attack in Sweden proved last weekend, he needs a crash course.
We're here to help.
The Sweden episode was a perfect circle of misinformation, beginning with a report on Fox News on Friday, since challenged, about the dangers of immigration in Sweden. Trump apparently saw that and brought it straight into his campaign-style speech the next day in Florida, in exaggerated form:
"We've got to keep our country safe. You look at what's happening in Germany, you look at what's happening last night in Sweden."
When the reference caused an international ruckus, he capped it off, not by setting the record straight, but by a blame-shifting tweet that, as usual, fingered the media.
America's longtime ally didn't take it well.
"Sweden? Terror attack? What has he been smoking?" fumed former prime minister Carl Bildt.
The gravity of the issues raised by the events that led to national security adviser Michael Flynn's resignation cannot be overstated or ignored. Revelations about Flynn's contact with the Russians and reports indicating that he may have lied to the FBI about that contact may be only the tip of the iceberg. There's an overwhelming view in our intelligence community that Russia tried to influence our election.
The American people, and indeed American democracy, require a thorough and independent investigation into what transpired and whether any criminal laws or constitutional precepts were violated. Such an investigation and any resulting prosecution would normally be carried out under the purview of the attorney general, as the nation's chief law-enforcement officer with oversight of the Federal Bureau of Investigation. But in this case, given his deep and long-standing ties to President Donald Trump and many of Trump's top advisers, Attorney General Jeff Sessions cannot lead such an investigation.
The Lord is my shepherd. OK? Totally. Big league. He is a tremendous shepherd. The best. No comparison. I know more than most people about herding sheep. And that's why I won the election in a landslide and it's why my company is doing very very well. Because He said, "I'm with you, Donald. You will never want."
So we were on this green pasture by the still waters and He said, "Lie down." I said, "Lie down?" He said, "Lie down." And He made me lie down. Right there in the pasture. So I lie down. People are so surprised that I lie down -- "Oh, he's lying down." But He's my shepherd. Great shepherd. Not just good. Great. It was right there that I thought, "This is going to be a tremendous golf course. Terrific greens. Plenty of water. And it is. Everybody who plays it comes away saying, "That is the greatest course in the entire world." Everybody.
The mystery at the core of the Trump-Russia story is motive.
President Donald Trump certainly seems to have a strange case of Russophilia. He has surrounded himself with aides who have Russian ties. Those aides were talking to Russian agents during the campaign, and some are now pushing a dubious peace deal in Ukraine. Trump recently went so far as to equate the United States and Vladimir Putin's murderous regime.
But why?
It's not a simple question. In their Russia-related inquiries, the FBI and the Senate Intelligence Committee will need to focus first on what happened — whether Trump's team broke any laws and whether the president has lied about it. Yet the investigators, as well as the journalists doing such good work reporting this story, should also keep in mind the why of the matter. It will help explain the rest of the story.
Questions to ask after one month of Trump:
-- Is Stephen Colbert our new Edward R. Murrow?
-- Is Stephen Miller a human or a hologram?
-- The same for Kellyanne Conway: real or Memorex?
-- If the media are, as Donald Trump says, enemies "of the American people," why are members of the press genuflecting at his knee? Why are they indulging him at all?
What would Ed Murrow say about Donald Trump? I promise you it would be curt.
In 1953, the CBS icon initiated Sen. Joseph McCarthy's fiery fall from eminence by assailing his "hysterical disregard for decency and human dignity."
Sixty-four years later, and on the same network, Stephen Colbert is taking on a president and his mouthpieces who show hysterical disregard for truth.
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5340 Werk Road UNIT 1,Green Twp OH, 45248
Sold Price
2 beds , 2 Full baths
1,007 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Professional Realty
(800) 599-8936
Last Updated: 2/27/2017 9:21 PM
Description for 5340 Werk Road UNIT 1 Green Twp, OH 45248
Great Location! 1st floor condo no steps. Walk or Roll in & out to car at DOOR! Walk to Western Hills Shopping Center, Post Office, Big Lots, Bed & Bath, Outback Steak House, Gold Star Chili, Dunkin Donuts, Kroger's, Sears Dollar Tree, Restaurants Planet Fitness. Minutes to I-75 & Downtown. Close to Mercy WEST! Inground POOL! Club House! CAR PORT!
Listing Information
Green Twp.
Public Water Service
Public Sewer
Natural Gas, Cable TV
School Information
Room Information
Floor - W/W Carpet, Walk-In Closet
Floor - W/W Carpet
Floor - W/W Carpet, Formal
Floor - Linoleum/Vinyl
Interior Features
Range-Oven, Dishwasher, Garbage Disposal, Refrigerator, Dryer, Washer
Carpet Wall to Wall
Central Air
Gas Heat, Heat Pump
Aluminum Frame
1, Wood-burning, Fireplace
Exterior / Lot Features
1 Garage Spaces, Carport, Off Street, 1 Car
Less than .5 Acre
Pool House, Close to Bus Line, City Road, Level
Community Features
Bus Line
Financial Considerations
Inside AccessTM
Current market conditions for 5340 Werk Road UNIT 1
Active Market Trends
Source:MLS DATA
Median list price$139,900
Days on market99
Properties for sale217
Sold Market Trends
Source:MLS DATA
Median sold price$125,000
Sales to list price9,667.0%
Properties sold229
Median sq ft price$80
Arrows indicate 90 day trend
Listing Price History for 5340 Werk Road UNIT 1
Green Twp Real Estate
Green Twp is located in Ohio.
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Avatar: The Last Airbender/The Beach
From The TV IV
|The Beach
|Season 3, Episode 5
|October 19, 2007
|Production Number
|← 3x04
Sokka's Master
|3x06 →
The Avatar and the Firelord
|Avatar: The Last Airbender — Season Three
| This article about an episode needs to be expanded with more information.
Please help out by editing it.
The Beach is the fifth episode of the third season of Avatar: The Last Airbender, and the forty-fifth episode overall.
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Horse Mountain (Trail 527) is a 2.8 mile out and back trail located near Belgrade, Montana. The trail is good for all skill levels and primarily used for mountain biking.
kid friendly
mountain biking
hiking4 years ago
Great hike! It's an old road so an easy hike however there is a steady climb on the way up. The little stream runs the entire trail, the dogs loved it! Beautiful rock formations all along the way.
I saw a couple of 4-wheelers while I was on the trail and it would be great for mountain biking also. I'm trying to post photos but the site is having issues with this so I will keep trying.


text: Workshops Share Share this page on Twitter Share this page on Facebook Share this page on LinkedIn Print this page Email this page Page ContentPlease note that advance registration is required for all workshops, and most have limits on the number of participants. Spouses may register on a space-available basis. Please pre-register for each workshop by calling (202) 466-7230. Sunday, January 5, 2:00–4:00 p.m. Considerations in Online Education: What to Do about MOOCs, Virtual Programs, and Regulatory Requirements (Sponsored by The Chronicle of Higher Education)Traditional independent colleges and universities are being peppered with different approaches to learning that confront, confuse, and confound leaders, rearrange priorities, and cloud mission. Moreover, the use of technology in teaching and learning is changing rapidly, further complicating planning and decision making. What do presidents need to know about these issues to evaluate, initiate, or further develop the institution's use of online education? How will presidents decide which (if any) approaches help the bottom line and contribute to institutional sustainability? Experienced presidents and knowledgeable consultants will lead informed discussions of these questions and the following topics: Current trends and practices in online learning at independent colleges, based on a new survey of CIC chief academic officers; Online course options: hybrid, blended, or completely online; Online development and delivery options: outsource, insource, or collaborate; MOOCs and their potential to supplement course offerings; Implications for marketing, recruiting, and serving students in online programs; and Navigation of regulatory requirements. David L. Clinefelter, Chief Academic Officer, The Learning House, Inc. Thomas R. Kennedy, Executive Director (retired), New Ventures of Regis University Kevin J. Manning, President, Stevenson University Frederick V. Moore, President, Buena Vista University Elizabeth J. Stroble, President, Webster UniversityChair: Diana O. Stano, OSU, President, Ursuline College Fee: $75 Sunday, January 5, 2:00–4:30 p.m. Strategies for Building More Effective Boards (Sponsored by Witt/Kieffer)The breadth of issues being discussed by college and university trustees constitutes a new kind of stress test of governing board competence. What strategies can presidents employ to develop more effective boards? How can presidents help reposition their boards to be constructive partners in making difficult decisions? In a highly participatory session, presenters will lead a series of discussions on the following issues: Board development methods; In-service trustee education programs; Approaches to strengthen president and board chair relationships; and Strategies to reposition the board for constructive engagement. Lori Bettison-Varga, President, Scripps College Richard T. (Tom) Ingram, Senior Advisor for President-Board Relations, CIC and Former President, Association of Governing Boards of Universities and Colleges Ronald R. Pressman, Executive Vice President and Chief Operating Officer, TIAA-CREF Jon C. Strauss, President, Manhattanville College Robert L. Wyatt, President, Coker CollegeChair: Denvy A. Bowman, President, Capital University (OH) Fee: $50 Monday, January 6, 2:00–4:00 p.m. Winning Enrollment Management Strategies: Aligning Institutional Mission and Net Revenue Goals (Thanks to the generous support of Miller/Cook & Associates, Inc., this workshop is being offered free of charge.)Too many college presidents are discovering that their traditional enrollment and financial aid leveraging models are strained and do not deliver needed enrollment and revenue outcomes. New strategic and tactical solutions are needed in today's environment as students and parents make enrollment decisions based upon perceived value. This hands-on workshop will examine five strategies that presidents can implement to align their enrollment management objectives with the institution's core mission and values while maximizing net tuition revenue. The issues addressed by these strategies are: How to build the case for value using media and messages most likely to influence core constituent groups; How to develop new search strategies that generate targeted, completed applications from students earlier in the application cycle; How to use the FAFSA (Free Application for Federal Student Aid) as a better predictor of enrollment than traditional approaches; How to realign an institution's financial aid strategies with core values and mission to maximize net tuition revenue and enrollment outcomes; and How to select assessment tools to judge the impact of enrollment management strategies. Catherine R. Cook, CEO, Miller/Cook & Associates, Inc. Robert E. Johnson, President, Becker College Philip T. Malinoski, Senior Vice President, Miller/Cook & Associates, Inc. William B. Miller, President, Miller/Cook & Associates, Inc. Rosalie M. Mirenda, President, Neumann UniversityChair: Jorge L. Diaz-Herrera, President, Keuka College


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8445 Island Pines Place,Deerfield Twp. OH, 45039
Sold Price
2 beds , 1 Full/2 Half baths
1,762 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Professional Realty
(800) 599-8936
Last Updated: 2/21/2017 3:21 AM
Description for 8445 Island Pines Place Deerfield Twp., OH 45039
Welcome to Island Pines in Landen. First floor is open floor plan design. Great new tiled bathroom with double vanities. Freshly painted. Finished lower level with a fireplace in the family room and also a finished study. New carpet throughout 9/2016. New bath 5/2016. Pool, trails- walk, bike.
Listing Information
Public Water Service
Public Sewer
Cable TV
School Information
Room Information
Family Room
Butler Pantry
Dual Sinks
Interior Features
Range-Oven, Dishwasher, Garbage Disposal, Refrigerator
Carpet Wall to Wall, Laminate
Central Air, Ceiling Fan(s)
Electric Heating, Heat Pump
Full, Finished
Insulated, Vinyl Frame
1, Wood-burning, Brick
Alarm -Smoke/Fire
Home Warranty Plan
Exterior / Lot Features
1 Garage Spaces, Attached Garage, Front Entrance, Driveway
Brick, Vinyl
Privacy Fence
Financial Considerations
Inside AccessTM
Current market conditions for 8445 Island Pines Place
Active Market Trends
Source:MLS DATA
Median list price$394,000
Days on market85
Properties for sale94
Sold Market Trends
Source:MLS DATA
Median sold price$221,005
Sales to list price9,791.0%
Properties sold117
Median sq ft price$106
Arrows indicate 90 day trend
Listing Price History for 8445 Island Pines Place
Deerfield Twp. Real Estate
Deerfield Twp. is located in Ohio.
Loading nearby sales and history ...
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Berkshire Hathaway HomeServices Professional Realty
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Performance and Scalability
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Read-only database in SAN Mounted by multiple reporting servers Applications access a consistent copy from any server
Data is partitioned horizontally across multiple servers Transact-SQL view retrieves all data with a UNION ALL clause Requests can be directed by using data dependent routing
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SQL is generated from standard querying language Based on classes mapped to the tables var query = from c in context.Customers where c.Country = "Luxembourg" select new { c.LastName, c.FirstName }; var query = from c in context.Customers where c.Country = "Luxembourg" select new { c.LastName, c.FirstName };
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Matrix Total Results Moisture Conditioner is a nourishing conditioner, ideal for dry hair.
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6 Brilliant Ways To Wear Metallics During The Day
We've never really been adamant followers of occasion-based dressing. In our book, a sequin skirt can be worn with sneakers to brunch, a bustier layered
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We've never really been adamant followers of occasion-based dressing. In our book, a sequin skirt can be worn with sneakers to brunch, a bustier layered
Even on a Saturday night, the appeal of a plush sofa, a pint of fro-yo, and your worn-in sweats is enough to make you choose hibernation over celebration.
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