text:
|Your Futurama quote for the day
|attached to Up To 35,000 Gallons of Nuclear Waste Leak At Washington State Storage Site
|Sensitive information
|attached to Childbirth Charity Hack Leaks 15,000 Expectant Parents Data
|Keep Bruce Willis safe!
|attached to New Metal Foam Armor Obliterates Bullets To Dust On Impact
|attached to Moscow State University Releases 10th HEVC Video Codec Comparison
|Perpetual energy machine
|attached to Saturn's Moon Enceladus Has Global Subsurface Ocean
|Re: Can I jump ship yet?
|Can I jump ship yet?
|attached to OpenGL Library Mesa 11.0 Brings Open Source OpenGL 4
|Re:Sony Pictures == Columbia, a California company
|Explain it like I'm five
|attached to US Slaps Sanctions On North Korea After Sony Cyberattack
|Re:You need more nuclear and less renewables
|attached to Ask Slashdot: Why Is the Power Grid So Crummy In So Many Places?
|Re:Shyeah, right.
|attached to Is LTO Tape On Its Way Out?
|Re:Dear Sony, I am delighted!
|attached to Sony Pictures Computer Sytems Shut Down After Ransomware Hack
|Never useful info given with patches
|attached to Microsoft Releases Replacement Patch With Two Known Bugs
|Seeking open source alternative
|attached to Who's On WhatsApp, and Why?
|Sounds like a plan!
|attached to Researchers Develop "Narrative Authentication" System
|No credibility
|attached to US Intercepts Iranian Order For Attack On US Embassy In Iraq
|Simpsons did it!
|attached to Uncle Sam Finally Wants To Hear From Us On Digital Copyright Law?
|/tinfoilhat on
|attached to As AOL Prepares To Downsize Patch, CEO Fires Employee During Meeting
|Let's chant the mantra..
|attached to Other Agencies Clamor For Data NSA Compiles
|Re:Their loss
|Why do the heavy lifting yourself?
|attached to Several Western Govts. Ban Lenovo Equipment From Sensitive Networks
|Fool me once..
|attached to US Promises Not To Kill Or Torture Snowden
Consultants are mystical people who ask a company for a number and then give it back to them.


text: As you may recall I had problems with Norton Antivirus Suite 2006. After I installed & uninstalled it and installed it again and it still didn't work, I uninstalled it again and took it back. I tried downloading some Anti Virus Programs online, nothing worked. I was going to take Moses (my computer) to my ISP tomorrow and let them have a go at it. I prayed about it, as I thought I should take another shot at it today. God reminded me, last year I was having problem opening my junk mail. My ISP suggested I pick up a CD from them, that should take care of the problem. well I did and it didn't cure the problem. One of the techs suggested I switch to Firefox, that took care of the problem. They told me to just keep the CD. Anyway I loaded the CD and everything just came together. I downloaded AVG free and ran it, it ran for over an hour and found no viruses. However one of the Antivirus programs I uninstalled came back and started to run. I stopped it and clicked it off, went back to the Control Panel, install/uninstall and that program wasn't there, it hasn't come back. Does anyone have any ideas? Other than that, everything seems to be ok.

subset: commoncrawl


text:
With technology like this, backpacks will be obsolete one day.
The problem with kids these days is that they just want to spend all their time staring at things on screens. If you just hand your kid a boring old book, they're going to see immediately that it doesn't have any buttons or screens and they'll lose interest. But put that same boring old book on a screen, and suddenly it's their new favorite video game!
e-Go! Portable Children's AudioBooks http://kids.woot.com/offers/e-go-portable-childrens-audiobooks
$24.99 In Stock Electronics > Computers
$24.99 USD false 1 Retail EA
1 3
Woot! Kids.Woot http://kids.woot.com
4121 International Pkwy Carollton TX 75007 U.S.A.


text:
Machine tools three-roll rounding off
Found: 13 products← Back to category "Bending machines and equipment"
Obrezchik of corners for metal plates
Price:439.18 EUR
Wholesale price:418.33 EUR(from 2 pcs)
Obrezchik of corners for metal plates Read more
Allbiz trust company more than 6 years
Delivery fromUkraine
This company received an enquiry 2 day ago
Display phones
Site: tyrfan-trade.in.ua
3rd roll rollers of UZMA 3R HS
Price:36000 EUR
Functional features Rollers three-roll are intended for are flexible cylindrical and conic feedwells from a leaf of various thickness. Situation to Read more
Verified partner for over 4 years
Premium Business
Delivery fromUkraine
This company replies on the enquiry during 24 hours
Display phones
Site: metstan.com.ua
Rollers the hands of ST-m of 1500
Price:790.34 EUR
Gibstanki's company offers manual listogibochny rollers of ST-m of 1500 with a length of the working field of 1500 mm for a pr-v of pipes and air duct Read more
Verified partner for over 6 years
Premium Standard
Delivery fromRussia
Display phones
Site: gibstanki.ru
Didn't find required product?
Suppliers will contact you
For last 30 days 107913 leads received the offers from the companies
Trading platform Allbiz offers to see the catalog Machine tools three-roll rounding off which contains 13 products offers from 3 companies and enterprises. Don't know what Machine tools three-roll rounding off to buy? You can clarify the specifications, see photos Machine tools three-roll rounding off and choose the best seller and supplier. Buy Machine tools three-roll rounding off trough online ! On Allbiz — You can just place your order right on the site.


text:
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text:
This is the March 3, 2013 news archive. View today's Astros rumors and news.
Houston Astros
Houston Astros News and Rumors
Recap: Pirates 8, Astros 6
chron.com Updated Mar 3, 2013
BRADENTON, Fla. - The Astros fell 8-6 to the Pittsburgh Pirates on Sunday in a Grapefruit League game at McKechnie Field. Recap: A five-run second inning pushed the Pirates ahead to stay. Pittsburgh hit Astros starter John Ely hard, knocking the right-hShare Tweet


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Stream hundreds of free workout videos and track them in one click. Get fit at home, at work or wherever you are!
Today's Featured Video:
Yoga for Everyone: Cooldown and Savasana
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Access hundreds of thousands of recipes that are healthy and easy to make. Get full nutrition info for every recipe and track with one click!
Today's Featured Recipe:
Vanilla Flavoring
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HELEN_BRU's Blogs
Happy St. Paddy's Day!
Sunday, March 17, 2013 15 comments
Have a great day! ...
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Just Had To Tell You The News!
Saturday, March 16, 2013 26 comments
I'm on a 5% Challenge and my teammates are the Dawgs
and this morning was weigh-in and I LOST 2.8 l...
Read more
Friday, March 15, 2013 17 comments
Maybe not for all, though. But I'm 78 and finally there is something that works for me. For those who have read my past blogs, know that I am - or supposed to be - on a restricted diet. (I am following it faithfully with two exceptions ...
Read more
Day 6 - Do You Need Some Motivation or Advice? Ask for it!
Thursday, March 07, 2013 13 comments
Funny thing . . . I find no problem getting advice or motivation from my Spark Friends, without even asking! They are an alert bunch of great supporters! Yahoo! I think I'll keep them all. Thanks again for all your support this wee...
Read more
Day 5 - What Can I Improve Upon?
Wednesday, March 06, 2013 9 comments
Looks like I had two Day 4's.
I must get more exercise now that things are working better. Might ...
Read more
Day 4 - So How Am I Doing Day by Day
Wednesday, March 06, 2013 9 comments
Sometimes it takes a long time to get everything working right, and I feel that's been my case. With me, it was finding the "right" chiropractor (can't leave him out of the equation because without him, I'd still be "nowhere"), changing the...
Read more
Day 4 - So How Am I Doing?
Tuesday, March 05, 2013 19 comments
So far, am doing great! Dropped 4 plus some lbs. since I started about 4 days ago. I am eating right for me too - no problems so far. I do have an appt. with my chiro. this morning and I am sure he will get all defensive about the Omega 3...
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Excellent Results - Day 3 on Blog Challenge
Monday, March 04, 2013 16 comments
Just reporting that I've had excellent results - going back to a more healthy diet for me - find it is so easy to follow with no cravings that I used to get. The mystery is what was I doing wrong FOR ME before? Was it eating the night sh...
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How Will I Incorporate My New Habit?
Sunday, March 03, 2013 18 comments
Did I say I had a new habit? Maybe it's eating my Ancient Grains bread when I feel I really need it - otherwise sticking to my Perfect Health diet, which of course is a modified low carb diet for life! Get that last part? FOR LIFE! Now t...
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Room For Improvement!
Saturday, March 02, 2013 13 comments
I have lots of room for improvement here! Since I have to blog every day, maybe I should tackle this one first. How do I intend to improve? I've got the water down, so now I think I will watch my portions. I'm okay with everything bu...
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"Everything I Desire Is Within Me" - Centering Thought for the Day
Saturday, November 10, 2012 17 comments
That is Deepak Chopra's meditation for today. . . and here is the rest of what he has to say that I find so important because we have a tendency, or I do, to compare how we are doing weightwise with others on Spark. This will free you! ...
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Better Yet, WHO motivates YOU???
Sunday, September 23, 2012 19 comments
I just wrote a blog the other day asking What Motivates You. But, since we are all here on Spark, a better question might be. . . WHO motivates you??? And WHY??? I'm a self-starter myself. Oh someone might "light the fire" but in the...
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What Motivates YOU????
Thursday, September 20, 2012 9 comments
Here I am, with a clean slate - yup! I deleted all my old blogs, my accomplishments, etc. and am starting over. . . I'm no longer the "old" me - this is the brand new me and I'm ready for action. Joined the 5% Fall Challenge Team and ...
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Posted on August 11, 2010
Brand: Bear Paw Creek
Save with this Bean Bag & CD Bundle!
CD PLUS 1 Set of 12 Colorful Bean Bags!
Bean Bag Fun CD
By Laura Johnson & Diane Waldron
Fun-filled games and activities that develop coordination skills. Original music and sing-along lyrics are ideal for early elementary. Also includes tracks of music only. Activities list enclosed.
For primary grades, ages 3-8.
Bean Bag Kick Line (eye hand/ eye foot coordination), Tom Tom Bean Bag (left/ right discrimination), Bean Bag Carousel (individual toss & catch), On the March (balance, body identification), Beanie's Song (partner toss & catch), Musical Bean Bags (passing game - fast & slow).
No reviews available.
Posted on August 11, 2010
Posted on September 29, 2015
Posted on June 03, 2011


text:
Bulk Food
- Cereals
- Hot Cereal
- Malt-O-Meal Hot Cereals
- Malt-O-Meal Original Hot Wheat Cereal 28 Ounce
- Last products viewed
Malt-O-Meal Original Hot Wheat Cereal 28 Ounce Product ID: OT458297 Malt O Meal
- "My orders always go perfectly...and this one was very fast … thank you!
- "With all of my orders I was satisfied and happy I got them and there were good. See you in 2 months!
Malt-O-Meal Original Hot Wheat Cereal 28 Ounce
Product Id: OT458297
Sold as: Case of 18Weight: 35.4 lbs
List Price: $121.80Savings: $28.95
DescriptionSpecial Order Item No ReturnsFood Item No ReturnsMalt O MealMfg#: 105
Malt-O-Meal Hot Wheat Cereals give your family essential nutrients they need for growth, plus hearty goodness to get them through the morning. Its not just great taste - its more of what hot cereals for.
Malt-O-Meal Original Hot Wheat Cereal, 28 Ounce -- 18 per case.
Food items cannot be returned.
Hot products
Chef Pierre Chocolate Mint Layer Cream Pie product id: OTF433101 Baked Goods
Lipton Lemon Flavor Herbal Tea product id: OT215271 Coffee, Tea and Cocoa
Our commitment to you
FoodServiceDirect.com stocks 1,000's of items including Malt-O-Meal Original Hot Wheat Cereal 28 Ounce. Quality Customer Care is our first priority - try calling us at 757-245-7675. FoodServiceDirect.com has been supporting the foodservice industry since 1989 - when it comes to Malt-O-Meal Hot Cereals or any of our other thousands of foodservice items, count on us for dependable delivery and secure shopping!


text:
Is Sinag Tala Pharmacy incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
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Hotfrog Philippines provides information regarding Sinag Tala Pharmacy in Caloocan Metro Manila. Sinag Tala Pharmacy is located at Street Joseph Avenue, Caloocan Metro Manila and provides Churches services. Contact them on (02) 961 1524.
Is Sinag Tala Pharmacy in Street Joseph Avenue, Caloocan Metro Manila your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Churches services in Caloocan Metro Manila available on Hotfrog Philippines. You can update your search for Caloocan Churches by location, keyword or service options.
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English Meaning
That branch of mathematics which treats of the relations of the sides and angles of triangles, which the methods of deducing from certain given parts other required parts, and also of the general relations which exist between the trigonometrical functions of arcs or angles.
- The branch of mathematics that deals with the relationships between the sides and the angles of triangles and the calculations based on them, particularly the trigonometric functions.
Malayalam MeaningTransliteration ON/OFF | Not Correct/Proper?
ത്രിമാനഗണിതം - Thrimaanaganitham | Thrimanaganitham ;ത്രികോണമിതി - Thrikonamithi ;ത്രികോണമിതി. - Thrikonamithi. ; ;ത്രികോണമിതി - Thrikonamithi ;


text:
francois of Ottawa said: "Very courteous, relaible and professionnal.
Did a great job- highly recommended...Read more
Description: Roundbox Construction offers residential framing / carpentry services to the greater Ottawa area....more
Description: Miragetek construction is customer oriented who gives extra attention to details with one goal in mind. CUSTOMER SATISFACTION. We also believe that Qu...more
Have you hired Kirk Builders Ltd? Write a review and share your experience!
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Have you hired TOFCON Construction? Write a review and share your experience!
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Description: Victory Construction and Renovation is located in the Outaouais, and specializes in interior finishing and renovation projects where the client se...more
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If you can't find the company you hired and want to submit a review, add them to the TrustedPros directory.
Post your project and within hours you'll be comparing offers from top-rated and trusted
professionals. It's free to post and you're under no obligation to hire.
Post your project and compare offers from top-rated pros.


text:
Which Joe gave his name to 'sloppy joes'? We look at five interesting sandwiches and their lexical origins.
Definition of abranchiate in English:
obsolete, rare
Originally: †belonging to a former group Abranchiata or Abranchiatae of annelids (obsolete). In later use: (more generally) having no gills; not bearing gills.
Mid 19th century; earliest use found in Henry McMurtrie (1793–1865). From a- + ancient Greek βράγχια gills + -ate, after scientific Latin Abranchiata, Abranchiatae, group names, which are in turn after French Abranches, plural noun. Compare French abranche (adjective) belonging to a former group of annelids.
We take a look at several popular, though confusing, punctuation marks.
From Afghanistan to Zimbabwe, discover surprising and intriguing language facts from around the globe.
The definitions of 'buddy' and 'bro' in the OED have recently been revised. We explore their history and increase in popularity.


text:
The minimal price on the Steam market 0,69 q.
Sanguine Moon Belt
Dota 2
Common belt
Used By: Lycan
Armor of the Sanguine Moon
Sanguine Moon Armor
Sanguine Moon Belt
Sanguine Moon Shoulder
Sanguine Moon Weapons
Sanguine Moon Patch
Some have questioned the fashion sense of using a skull for a belt buckle. The last guy who questioned it became a second belt buckle.
The appearance of items in the list below may differ from the above. For example, items may have different names, descriptions, colors, stickers, gems. Before buying hover on the image of the item to view its full description.


text:
FREE SHIPPING on orders over $50.
Quantity Available:
For over a decade, New York based designer Sandy Chilewich has been creating original and innovative vinyl products for the home. Her woven, tufted, molded and spun textiles are available in a range of vibrant and neutral hues that have become synonymous with the Chilewich brand name.
The Solid Shag Runner is available with the following:
- Designed by Sandy Chilewich in 2012
- Material: Tufted vinyl
- Good in all weather
- Quick to dry
- Mold and mildew resistant
- Greenguard certified (protects human health and quality of life through reduced chemical exposure and improved air quality)
- UL Listed
- Made In USA
Color: Black, Mercury
- Item: Length 72", Width 24"
Ratings: Based on 1 reviews, this product is rated 5.0 out of 5.
Manufacturer IDs: view
200139-001, 200139-002
Need help with some of our terminology? Check out Lumens' Lighting & Design Glossary.
Related Searches and Products
The Chilewich Basketweave Table Runner is low maintenance, elegant and affordable, blending traditional weaves with contemporary shades; often imitated but never replicated. The Basketweave Table Runner features Woven Vinyl with heat-sealed edges in a variety of vibrant and neutral hues. ...
An elegant floor mat inspired by street art. The Chilewich Woven Imprint Floor Mat has a jacquard weave that mimics hand-applied brushstrokes of paint. The overall pattern is imperfect, energetic and subtly metallic; a lovely addition to modern decor. The ...
A fluid look for interior or exterior spaces. The stripes in the Chilewich Block Stripe Shag Door Mat gradate in color from a very deep shade to a pale, dusty hue. The white lines that separate the even stripes give ...


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Ladies fashion retail unit with 2
Long established ladies fashion wear outlet with a 2 bedroom apartment over currently used as a holiday let. Located in a semi-detached stone building adjoining the entrance to the harbour side with triple aspect sea views. Originally the...
Location: Porlock, Somerset, England
For sale under: Clothes Shops, Retail Space, Ladieswear Retailers
- L/H Price
- £150,000
Niche Clothing and Accessories
Long established business that started trading in 1969 and has operated from the same town centre location for over 45 years. This is an iconic local business that has a Bohemian assortment of merchandise and a very strong following. Over...
Location: Taunton, Somerset, England
For sale under: Clothes Shops, Fashion Accessory Shops, Other Retail businesses, Ladieswear Retailers
- Price on Application
- Annual T/O
- £125,000
This business offers an eclectic and alternative assortment of quality merchandise that encapsulates the ethos and culture of this unique Somerset town. The owners have taken great care to source quality and exclusive merchandise which...
Location: Glastonbury, Somerset, England
For sale under: Card Shops, Clothes Shops, Fashion Accessory Shops, Gift Shops, Ladieswear Retailers
- Price on Application
- Annual T/O
- £221,000
Zik Zak, established in York city centre since 2000, offers the following:- * Situated on a popular and vibrant street * Within close proximity to York's prime retail area * 300 sq ft sales area plus additional ancillary space *...
Location: York, North Yorkshire, England
For sale under: Clothes manufacturing companies, Clothes Shops, Gift Shops, Printers/Print Shop, Retail Space
- L/H Price
- £35,000
We are delighted to offer J Anderson & Son for sale. The business specialises in the sale of a wide range of sports equipment, clothing and accesories, together with being a gunsmiths. The business has been established since 1830 and is an...
Location: Malton, North Yorkshire, England
For sale under: Clothes Shops, Sports Shops, Retail Space, Ladieswear Retailers, Gun Shops
- Asking price
- £175,000
SINGLE FRONTED MEDIUM SIZED SALES SHOP with tiled floor. Counter, slats to walls, display stands. SMALL WORKSHOP at rear. 2 machines for printing on shirts, additional lazer printer Office Cloakroom with w.c. & wash hand basin... Please...
For sale under: Clothes Shops, Sports Shops, Printers/Print Shop
- L/H Price
- £15,000
- Weekly T/O
- £500
A well established online business operating via a full e-commerce website. Specialist wholesaler of children's clothing with ranges from baby and toddlers through to teenage children. Established and operated by the current owner for over 8...
Location: England
For sale under: Childrenswear retailers, Clothes Shops, Wholesalers, Wholesale / Distribution businesses, Babywear Shops
- Asking price
REDUCED from £275,000 for a quick sale due to health reasons.A long Established Bespoke High Quality Gentlemen's Outfitters started in 1989 by the present owners. The business is situated in the heart of a town retail centre which over the...
Location: Colwyn Bay, Clwyd, Wales
For sale under: Clothes Shops, Dress Hire, Menswear Retailers, Online Retailers, Mens Formal Hire
- L/H Price
- £95,000
- Price Reduced
- Annual T/O
- £180,000
The business being offered for sale specialises in the sale of dance and sportswear clothing. It has been established for more than thirty years so it benefits from a high volume of repeat business. The shop has a good town centre location...
For sale under: Childrenswear retailers, Clothes Shops, Sports Shops
- L/H Price
- £40,000
Superb Well Established Business Annual Takings £45,000 GP 98% Very Well Known with Little Opposition Excellent Range of Equipment Handover Arranged EPC Rating - C Moreton Alterations has been established since approximately 1999 and has...
Location: Greasby, Merseyside, England
For sale under: Clothes Shops, Dry Cleaners, Tailors, Dressmaking, Clothing Alterations
- L/H Price
- £32,950
- Price Reduced
Town Centre - High Footfall WT £3,000-£3,500 Established 27 years / Website Included In Sale Loyalty card database of 2000+ Award Winning Retail Outlet EPC Not Required Blacks Brokers are delighted to bring to the market this award winning...
Location: Oldham, Greater Manchester, England
For sale under: Clothes Shops, Lingerie Shops
- L/H Price
- £14,950
- Price Reduced
Sports shop retailing a range of clothing, footwear, equipment and accessories associated with a large range of sports, including shooting and fishing. Also offering schoolwear supply. operating from extensive and versatile premises...
Location: Herefordshire, England
For sale under: Childrenswear retailers, Clothes Shops, Fishing Tackle Shops, Sports Shops, Other Retail businesses
- L/H Price
- £50,000
- Annual T/O
- £200,000
SUPERB BRIDAL WEAR BUSINESS WITH IN-HOUSE ALTERATIONS FACILITY Located close to rochdale centre which is undergoing continuing re-development Advised annual turnover of £125,341 with good gross profits Scope to increase online sales &...
Location: Lancashire, England
For sale under: Clothes Shops, Wedding Services, Bridal Wear Shops
- L/H Price
- £10,000
- Price Reduced
LEASEHOLD LADIES CLOTHING & ACCESSORIES SHOP Situated in the beautiful market town of Pershore, Worcestershire Exceptionally well presented and well appointed throughout Advised turnover £153,000 PA with good GP returns Early interest and...
Location: Worcestershire, England
For sale under: Clothes Shops, Fashion Accessory Shops
- L/H Price
- £45,500
- Price Reduced
This old established Tailors has been in the same hands since 1987 and is now solely offered for sale due to the vendor's retirement. SINGLE FRONTED PREMISES approx. 400 sq. ft. with tiled floor. 3 sewing machines, 2 steam irons with...
For sale under: Clothes Shops, Tailors
- F/H Price
- £98,000
- Price Reduced
- Weekly T/O
- £1,500
This superbly presented business retails brand name men's and women's clothing and accessories catering for the upper end of the market. This quality fashion store is located in a large and spacious three storey retail unit, which forms part...
Location: Northern Ireland
For sale under: Clothes Shops
- L/H Price
- £125,000
- Annual T/O
- £280,000
The property is arranged on ground and two upper floors to provide a ground floor banking hall with self-contained office accommodation on the first and second floors. The upper floors are accessed from a separate entrance on North Station...
For sale under: Clothes Shops, Other Retail businesses, Investment & Financial services
- F/H Price
- £1,750,000
The property is arranged on the ground with upper parts sold separately. Shop is part of a busy parade with lots of passing trade and would be suitable for any retail trade. Property measures approx 840 square feet. Property is available on...
For sale under: Clothes Shops, Other Retail businesses, Investment & Financial services
- L/H Price
- £199,000
Spacious single fronted Sales Shop approx. 665 sq. ft. sales area, carpeted. Fully equipped including shelving, counter, electronic cash register, display stands, rails etc. Large basement in the region of 1,330 sq. ft. with racking used...
Location: West London, London, England
For sale under: Clothes Shops, Fancy Dress Shops, Party Shops
- F/H Price
- £725,000
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Buying a Clothes Shop: What To Look Out For
Owning a clothes shop and becoming a fashion retailer is a dream for many, but it's important to understand the intricacies of this competitive and fast-moving industry before you invest.
Look closely at historical trading figures: whenever you buy a business as a going concern, you should see the trading figures for previous months and years. If the UK had a warm winter or a cold summer, this often affects clothes sales in that quarter. When looking at the books of the clothes shop you're about to buy, trading figures might look too high or too low to believe in a certain quarter, but it could be the weather. Scroll through the archives of industry news websites and see if that period's trading figures tie in with industry patterns.
Personally inspect any stock included in the sale: you need to know that the stock you're buying can be sold on at a profit. If the storeroom isn't full of goods that are on-trend and in demand, you will struggle to sell it at a good price. If you can't see a way to make a good margin on clothes that are beginning to fall out of fashion, then there's no point in including it in the sale price. As with all retail businesses, space is at a premium. It costs money to rent every square inch in your shop, so you don't want to fill valuable storage space with items you're never going to sell.
Research the local market: It's especially important to have a thorough understanding of your market before you make any changes to the clothes shop you have just bought. Make time to watch the footfall on the street outside the clothes shop at different times during the week. What is the demographic of the shoppers in the area? What other shopping bags are they carrying? How much do you think they have to spend on clothes every month, and how much of this spend do you think your clothes shop can reasonably capture?


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James Rollo
Techniques of Successful Self-Directed Work Teams
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ISBN: 0964666804Издательство: James Rollo
This workbook emphasizes Do-It-Yourself examples and steps to take in implementing the techniques of highly effective teams. Chapters are structured for ease of organization, reference and access. Each chapter begins with explanations of a technique and why the technique is critical for team success. Following the explanations are real-time examples of each technique. These are not fictitious or edited examples. These examples have been drawn from the files of successful service, manufacturing and hospital teams. Step-by-step processes for implementing each technique with associated worksheets follow the examples.
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ARLINGTON, Texas -- Mike Trout was in the lineup for Tuesday's game against the Texas Rangers as the designated hitter, getting a day off from playing in center field.
Trout has been in the starting lineup for all 45 games this season. This is the second time he will be the Angels' DH, a role he took for a win over Kansas City last month. Last season, he started 159 of the Angels' 162 games, a career high.
Kole Calhoun, who had an off-day on Monday, was back in the lineup. C.J. Cron was not in the lineup with Trout as the DH and Albert Pujols at first base.
Tonight's lineups:
3B Yunel Escobar
RF Kole Calhoun
DH Mike Trout
1B Albert Pujols
2B Johnny Giavotella
C Carlos Perez
SS Gregorio Petit
LF Rafael Ortega
CF Shane Robinson
SP Jhoulys Chacin (0-0, 4.76 ERA)
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text: Episode Info: There's a generation after the Millennials that looks like it will be even harder to reach than Millennials. Meet Generation Z —people born after 1991. Academic, theologian and Pastor James Emery White talks about what your church needs to do to reach them. Welcome to Episode 121 of the podcast. And who wants to win…Read more »


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CEO Preferences and Acquisitions
Dirk Jenter
London School of Economics; National Bureau of Economic Research (NBER); CEPR
Katharina Lewellen
Tuck School of Business at Dartmouth
June 5, 2014
This paper explores the impact of target CEOs' retirement preferences on takeovers. Using retirement age as proxy for CEOs' private merger costs, we find strong evidence that target CEOs' preferences affect merger activity. The likelihood of receiving a successful takeover bid is sharply higher when target CEOs are close to age 65. Takeover premiums and target announcement returns are similar for retirement-age and younger CEOs, implying that retirement-age CEOs increase firm sales without sacrificing premiums. Better corporate governance is associated with more acquisitions of firms led by young CEOs, and with a smaller increase in deals at retirement age.
Number of Pages in PDF File: 48
Keywords: Mergers & Acquisitions, CEO preferences, Principal-Agent Problems
JEL Classification: G30, G34, D21, D23
Date posted: December 8, 2011 ; Last revised: June 6, 2014
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Watch Amanda Knox: Murder on Trial in Italy Movie Online
Published 03 18, 2015
Year : 2011
Release date : 21 February 2011
Country: USA
Genres: Crime, Drama,
Director : Robert Dornhelm,
Writers: Wendy Battles,
Stars: Hayden Panettiere, Vincent Riotta, Paolo Romio, Marcia Gay Harden, Amanda Fernando Stevens,
Time: 87 min.
Quality: DVDRip/BDRip
Keywords: Watch Amanda Knox: Murder on Trial in Italy Movie Online
Amanda Knox: Murder on Trial in Italy.Update: On Oct. 3, 2011, Amanda Knox and Raffaele Sollecito were acquitted of murder on appeal in Italy. DNA experts determined the DNA on the so-called murder weapon was actually from bread crumbs (as in victim Meredith Kercher handling the bread and some crumbs ending up on the knife). Knox's conviction for slandering Diya Lumumba was upheld, though evidence came out that Knox had implicated the bar owner after 50 hours of interrogation without a lawyer present. As of Oct. 3, 2011, Knox's parents still face trial for slander for accusing Italian police of brutality and intimidation.


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Making Empire
Colonial Encounters and the Creation of Imperial Rule in Nineteenth-Century Africa
By (author) Richard Price
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Making Empire by Richard Price
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Book DescriptionThis is the dramatic story of the colonial encounter and the construction of empire in Southern Africa in the nineteenth century. What did the British make of the Xhosa and how did they make sense of their politics and culture? How did the British establish and then explain their dominion, especially when it ran counter to the cultural values they believed themselves to represent? In this book, Richard Price answers these questions by looking at the ways in which individual missionaries, officials and politicians interacted with the Xhosa. He describes how those encounters changed and shaped the culture of imperial rule in Southern Africa. He charts how an imperial regime developed both in the minds of the colonizers and in the everyday practice of power and how the British imperial presence was entangled in and shaped by the encounter with the Xhosa from the very moment of their first meeting.
Buy Making Empire book by Richard Price from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780521718196
(228mm x 152mm x 21mm)
Pages: 412
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 16-Oct-2008
Country of Publication: United Kingdom
Other Editions...
Books By Author Richard Price
New York Times Book of Crime, Hardback (April 2017)
For 164 years, The New York Times has been a rich source of information about crime. This fascinating compilation captures the full sweep of the newspaper's coverage of the subject and also examines issues like incarceration, organised crime and vice. Chapters are organised by topic and include explanatory material by Flynn to provide context.
Moon for Sale, Paperback (January 2017)
These are sensual, shapeshifting poems by this award-winning and "compelling pleasurable poet" (The Guardian), which unfold like a series of haunting dreams.
Whites, Paperback / softback (February 2016)
Originally published in hardcover in 2015 by Henry Holt and Company.
Homicide, Paperback (July 2015)» View all books by Richard Price
The bestselling true crime classic from the creator of The Wire, is now a canon
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Author Biography - Richard Price
Richard Price is Professor and Chair at the Department of History, University of Maryland, College Park. His previous publications include Labour in British Society 1780-1980 (1986) and British Society 1680-1880: Dynamism, Containment and Change (1999).
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Extreme dry skin
Extreme dry skin on and around lip area since more than 7 months. I did see a specialist but no help from the treatment since 2 months now.
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Doctor Answers (1) on Extreme dry skin
Dr. Harsha
Bangalore | General Physician
Hello there...it looks like you could be suffering from cheillitus. Cheillitus could be due to manu causes like increased sun exposure, dryness, candidiasis. You will have to be examined once to determine the cause. Treatment will usually include emollient along with sunscreen lip balms (in mild cases). In severe cases you might require mild steroid. So kindly consult a dermatologist for further evaluation and treatment.
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JEFFREY A. CARMEN, PH.D. MANLIUS, NY ISNR Progress in Biofeedback in Application to Migraine August, 28, 2008 7:30pm
DVD HANDOUT Lots of useful information. Most important part is International Headache Society diagnostic system. Distributed with permission.
pIR HEG Efficacy. Very high. Similar to peripheral vascular training but much faster – fewer sessions – more rapid reductions 10 to 15 minutes in one session to "turn off" a migraine. This requires a re-evaluation of theoretical mechanisms of migraine. 6 sessions for a 90% prophylaxis rate for symptom reduction to where the migraine sufferer has a difficult time telling if the headache was a migraine or not. I have now accumulated over 200 "relatively clean" migraine cases. The original observation of 6 sessions for a cutoff still holds.
pIR HEG (continued) As the number of sessions increases, migraines progressively "soften". The migraine "events" probably never stop, but they become difficult to detect. This is "management" not "cure". There is no specific treatment stopping point. Sessions are spread out farther and farther based on symptom stability and patient comfort levels. It is expected that migraines will return under extreme stress such as college (drinking, variable sleep, exam stress, etc.). Refresher sessions bring control back quickly.
NEGATIVE ASPECTS TO MIGRAINES They usually hurt a lot. They disrupt daily life activities. They increase the risk for both occlusive and hemorrhagic stroke, and may be a risk factor for cardiovascular disease.
POSITIVE ASPECTS TO MIGRAINES This is my own speculation: 50,000 years ago, migraines may have worked as an efficient detection system for rapid reduction in barometric pressure (storm detection).
MORE GENERAL DIAGNOSTIC CRITERIA FOR CLINICAL WORK A headache that hits at the end of a hard day or hard week is probably migraine. (Tension-Type headaches tend to rise with stress and decrease as stress decreases.) A headache that hits just before a big storm moves in is probably migraine. A headache that hits just before the menstrual period begins is likely to be a migraine. With a migraine, pain is optional.
WHAT IS KNOWN WITH SOME CERTAINTY Migraines and Tension-Type headaches are probably different in terms of pathophysiology. Migraines represent a cluster of slightly different entities with different genes involved. Cortical Spreading Depression appears to be validated. Attacks originate from a mechanism that involves the trigeminal nerve, the brainstem, and to some extent the vascular system. They can be managed, but the essential condition or predisposition does not go away. Think "management" not "cure".
MORE Migraines are a brain event, similar to a seizure. Migraines have two major stages: –1. Silent with or without definable aura. The aura is usually visual but may be auditory, cognitive, emotional. –2. Headache.Note: not all migraines have the second stage. Some people only have the first stage. –Migraines without aura may (probably) still have a first stage, but it may be difficult to identify.
INTERESTING COGNITIVE ASPECTS 1 ST stage may last a long time, hours to days, possibly weeks. Symptom may be "floating" learning disabilities. This may be the case for a person who has a bad day or two in school, then gets a bad headache, then is fine.
EFFICACY MEASURES FOR MIGRAINE INTERVENTION FREQUENCY - unreliable INTENSITY – subject to "drift" DURATION – somewhat reliable but most people sleep migraines off so don't know when they quit These are potentially useful but also problematic
PAIN LEVEL CUTOFF For my work I use the criteria of the point at which the person has difficulty telling if the headache they just had was a migraine or not. Nice practical working measure.
BIOFEEDBACK INTERVENTIONS HISTORIC: Gold Standard – peripheral thermal training – temperature sensor on finger – effective training for increase but also works by training for a decrease of finger temperature. Based on vascular theory of migraine, which turned out to be an incorrect theory. Valid treatment based on invalid theory.
HISTORIC PERIPHERAL THERMAL TECHNOLOGY Physical analog meter. Needed log response to increase resolution. Good to.1 degree with electronic enhancements beyond. Very effective
BIOFEEDBACK INTERVENTIONS MORE RECENT EEG (electron based Electroencephalography feedback) – feeding back brain wave data. HEG (photon based Hemoencephalography feedback) – feeding back brain blood flow data. These methods are at least as effective as peripheral thermal training, but tend to produce stable effects much more quickly. It is possible that the effect is also stronger due to improved frontal inhibition.
EEG Covered by the other presenters in this symposium: Siegfried Othmer, Ph.D. Deb Stokes, Ph.D.
HEG (PIR format) Developed by me about 10 years ago, to apply infrared detection to peripheral and central vascular function. Measures the thermal waste product of brain metabolism. Originally applied to migraines to train a reduction in excessive cerebral blood flow. (Based on the old vascular theory of migraine.) Did not work! Applied to forehead train an increase did work. The probable reason it works has to do with chopping off the head of a chicken!
The function of a chicken's brain becomes evident when it is slaughtered the old fashioned way, by chopping the head off with an axe on a chopping block. The chicken jumps up, runs around, flaps its wings, makes noises, and jumps in the air. Then it drops motionless. The reason is that much of the function of the chicken brain is to inhibit automatic actions. Chickens are not noted for their intelligence. Most of their behavior is automatic based on genetic programming. Humans are somewhat similar. The human brain, while massively more intelligent than a chicken's brain has some similar inhibiting functions. In this case, the frontal lobes of the human brain relate to the rest of the human brain in a manner similar to the way the whole chicken brain relates to the rest of the chicken's body. Damage to the front of the human brain, or chronic disuse, results in a reduction of inhibition. Under conditions of stress, the inhibiting functions of the human brain are supposed to temporarily turn off to allow emergency "fight or flight" responses. Under conditions of chronic stress the frontal inhibiting functions remain inactive. This normal inhibition is useful and in fact necessary for the maintenance of brain stability. Reduced frontal inhibition allows the already irritable migraine brain to erupt into a full blown migraine headache.
pIR HEG HEADSET
TECHNICAL NOTES The headset is the core of the pIR HEG system. It picks up infrared radiation from the forehead in a uniform 1.5 by 1.9 inch rectangular field of view. This infrared output increases when the person concentrates intensely with simultaneously relaxed emotions. Exercising this mechanism has the effect of maintaining increased brain stability. This also has the effect of making the migraine mechanism "sloppy", producing headaches that are less intense or with no pain at all. The person still retains the genetic predisposition for migraines, and in fact will still have migraines but they are much less troublesome. Sometimes they are evidenced only by painless "events" that require careful self observation to detect.
TECHNICAL NOTES The software regulates the interaction between the hardware and the computer. It produces a situation in which the person's mental state must flip back and forth between a passive mental state and an active mental state. This helps encourage a flexibility of brain responses, based on situational demands. It also encourages a dominance of the frontal inhibition systems.
PIR HEG CHARACTERISTICS 1. Infrared (unlike a contact sensor, there is no alteration of the thermal characteristics of the source). 2. Fast response time (< 80ms) 3. Field of view. Flat field of view, 1.5 inches high by 1.9 inches wide. Picks up large area of brain activity.
The preceding infrared image is unusual in that typically the headaches don't throw off that much surface heat. Yellow color indicates excessive thermal activity and in this case correlates with the area of extreme pain. Frontal pIR HEG training quieted it down to the level seen in the next image. Pain levels approximated the intensity of the image. There was minimal response until session #6.
DETAILS On a 0 to 10 pain scale, his first image was rated at "10". The post session image reflects a pain level of "3 to 4" on the same scale. Pain scales are notoriously unreliable, although they do reflect perception of discomfort. Regardless, dropping from "10" to "3 to 4" represents a significant change. This particular manifestation of his headache activity eventually quieted down to a pain level of zero and his headaches stopped being chronic. However he persisted in producing periodic migraine headaches for several months by which time they were reduced to a non troublesome status.
CAVEAT People don't lose the ability to generate migraines. This young man stayed reasonably well controlled until he went off to college. College life is not consistent with easy migraine management. They did return, although as intermittent rather than status migraine. They were also relatively easy to pull back under control.
Left temporal migraine Intense, throbbing pain
Pain gone 25 minutes, pirheg at Fpz
What do all these methods have in common? There are three biofeedback methods that stand out over other methods as having a repeatable positive effect on migraine management. These are: –Peripheral thermal training –Passive Infrared training on the forehead –EEG feedback The likely commonality among these three methods is that they all help quiet excessive brain irritability. PIR HEG and EEG biofeedback appear to have the additional effect of improving frontal inhibition. Ultimately as the strength of inhibitory mechanisms increases, it becomes more difficult for the migraine mechanism to generate a "high quality migraine". It gets "clumsy".
MIGRAINE TREATMENT REALITY Migraines probably do not get fixed or go away. If questioned carefully, most people will still have "events" the under the same conditions they used to have "migraines".
THIS IS THE END Thanks very much for coming.
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Tirapazamine (TPZ) [3-amino-1,2,4-benzotriazine 1,4-dioxide, SR4233, WIN 59075, and Tirazone™] is a novel anticancer drug that is selectively activated by the low oxygen environment in solid tumors. By killing the radioresistant hypoxic cells, TPZ potentiates the antitumor efficacy of fractionated irradiation of transplanted tumors in mice. As this cell kill is closely correlated with TPZ-induced DNA damage, we investigated whether human head and neck cancers would show DNA damage similar to that seen in mouse tumors following TPZ administration. TPZ-induced DNA damage in both transplanted tumors in mice and in neck nodes of 13 patients with head and neck cancer was assessed using the alkaline comet assay on cells obtained from fine-needle aspirates. The oxygen levels of the patients' tumors were also measured using a polarographic oxygen electrode. Cells from the patients' tumors showed DNA damage immediately following TPZ administration that was comparable to, or greater than, that seen with transplanted mouse tumors. The heterogeneity of DNA damage in the patients' tumors was greater than that of individual mouse tumors and correlated with tumor hypoxia. The similarity of TPZ-induced DNA damage in human and rodent tumors suggests that tirapazamine should be effective when added to radiotherapy or to cisplatin-based chemotherapy in head and neck cancers.
Tirapazamine (TPZ) [3-amino-1,2,4-benzotriazine 1,4-dioxide, SR4233, WIN 59075, and Tirazone™ (Sanofi-Winthrop, GreatValley, PA)] is currently in Phase II and III clinical trials as an adjunct to radiotherapy and to cisplatin-based chemotherapy. The drug has a unique mechanism of action that depends on its metabolism to an active species that occurs only under low oxygenation [1]. Such low oxygenation, or hypoxia, does not occur in tissues under normal physiological conditions, but is common in mouse and human solid tumors [2,3]. The hypoxia-dependent metabolism of TPZ leads to two principal activities. First, it increases the activity of platinum-based chemotherapy both with experimental tumors transplanted into mice [4], and with hypoxic cells in vitro [5]. Though this potentiation of cisplatin cell kill depends on the TPZ exposure being under hypoxia, it can occur in the absence of any cytototoxicity by TPZ [5]. The clinical effectiveness of the drug in enhancing the efficacy of cisplatin has recently been demonstrated in a multicenter randomized Phase III study comparing cisplatin plus TPZ with cisplatin alone in advanced nonsmall cell lung cancer. In this trial, overall response rates were doubled and survival time was significantly longer when TPZ was added to cisplatin compared to cisplatin alone [6].
In addition to sensitizing tumors to cisplatin, TPZ is preferentially cytotoxic to hypoxic cells both in vitro [7] and in tumors in vivo [8,9]. Hypoxic cells are resistant to killing by ionizing radiation [10] and are associated with lower local control rates following radiotherapy [11–13], as well as with increased metastases [14,15]. Because of its selective toxicity to the radiation-resistant hypoxic cells in tumors, TPZ increases the efficacy of fractionated radiation to transplanted tumors in mice [16,17]. However, it has so far been tested with radiotherapy of human cancers only in a small Phase II study with head and neck cancer [18], from which it is not possible to conclude whether TPZ will be effective when combined with radiotherapy. Though this question can only be answered definitively with randomized clinical trials, the expense and time involved in such investigations make it attractive to ask whether a biologic endpoint could be used to indicate whether TPZ might be effective in human tumors.
The present study was undertaken to determine whether TPZ-induced DNA damage could be used as such an endpoint for the activity of TPZ in human head and neck tumors. The logic for using such an assay is based on two findings. First, that potentiation of cell kill by fractionated radiation of mouse tumors is the result of TPZ killing the radioresistant hypoxic cells in the tumors [16]. Second, it is based on the finding that DNA damage measured by the comet assay is an excellent predictor of cell killing produced by TPZ both with cells in vitro [19], with spheroids in vitro and with transplanted tumors in mice [20]. We have also shown that DNA damage produced by TPZ in mouse tumors correlates both with tumor oxygenation and with radiation potentiation by TPZ [21]. Based on their data in mice, Olive et al. have suggested that the comet assay could be used to predict the efficacy of TPZ in clinical trials [20]. It was therefore of interest to ask whether measurable DNA damage would be produced by TPZ in human tumors, whether it would be comparable to that seen in mouse tumors, and whether it would show any relationship to tumor hypoxia. To date there is no information on the effect of TPZ on patients' tumors. In fact some findings have suggested that the efficacy of the drug might be less than that in mouse tumors, first because some mouse cell lines are more sensitive to TPZ-induced cell kill than human tumor cells [7,19], and second because mouse tumors are on the whole more hypoxic than human tumors [22]. This study therefore provided a means of assessing whether the TPZ doses were adequate, whether the human tumors were sufficiently hypoxic, and whether the cells had sufficient of the relevant reductive enzymes to metabolize TPZ to its DNA-damaging species. If any one of these were inadequate we would expect little or no DNA damage in the human tumors. However, comparable DNA damage by TPZ in mouse and human tumors would suggest that TPZ would be as effective when combined with radiotherapy of human tumors as it is with transplanted tumors in mice.
As part of an NCI-sponsored Phase II clinical trial for locally advanced squamous cell head and neck cancer, previously untreated patients with stage IV tumors and pathologically proven positive lymph node(s) were randomized to treatment with or without TPZ in combination with cisplatin-based induction chemotherapy followed by concurrent chemo-radiotherapy (Trial NCI-T94-01190). Before patient randomization, tissue oxygenation in the largest palpable lymph node was measured using the commercially available "pO2 Histograph" (Eppendorf, Hamburg, Germany). For these measurements, a stepper-motor-driven steel probe containing a glass-insulated micro-cathode (12 µm diameter) was inserted into the node along three tracks as previously described [23,24]. Approximately 60 individual oxygen measurements in the tumor were taken for each patient, from which median pO2 values and other estimates of tumor oxygenation were calculated. Those patients randomized to TPZ treatment also had fine-needle aspirates of the involved node both before and immediately after the first TPZ infusion (300 to 330 mg/m2) which was performed before any other treatment. Single-strand DNA breaks in the tumor cells from the aspirates were quantified with the comet assay (see below). The levels of single-strand DNA damage before and after TPZ in the same patients were compared to assess the tumor response to this drug. The patients described in this report represent the first 13 patients randomized into the TPZ-treatment arm. The Stanford University Institutional Review Board approved all the studies, and informed consent was obtained according to the Helsinki Declaration II.
C3H/Km and immunodeficient (SCID) mice were bred and housed under specific pathogen-free conditions in the Stanford University Research Animal Facility. All experiments were conducted according to the guidelines and directives set forth by the Stanford University Administrative Panel on Laboratory Animal Care. The human tumor cell lines used were the human HT1080 fibrosarcoma, obtained from the American Type Culture Collection, and the colon adenocarcinoma HT29 cells, obtained from Dr. R. M. Sutherland (SRI International, Menlo Park, CA). The mouse tumor lines used were the RIF-1 fibrosarcoma and SCCVII squamous cell carcinoma, details of the derivation of which have been published [25,26]. Each tumor cell line was maintained in accordance with a strict in vitro/in vivo protocol to prevent any genetic drift over time [25]. From monolayer cultures, single-cell suspensions (human cells per injection: 1x106 and mouse cells per injection: 2x105) were inoculated intradermally in the lower back of each mouse approximately 2 cm from the tail. Experiments were conducted approximately 2 weeks later when the tumor volumes were 100 to 150 mm3.
TPZ was kindly supplied by Sanofi-Winthrop (Great Valley, PA). The drug was dissolved in physiological saline at a concentration of 1 mg/ml and injected intraperitoneally according to body weight. Fine-needle aspirates were taken from the tumors to assess TPZ-induced DNA damage by the alkaline comet assay. Preliminary dose-response and time-course studies with the comet assay were conducted using the RIF-1 tumor. Based on these data and on previous experiments with the SCCVII tumor [21], further studies were conducted at a TPZ dose of 0.08 mmol/kg (=14.4 mg/kg), with fine-needle aspirates taken 45 minutes after TPZ injection to compare the DNA damage induced by TPZ in the HT1080, HT29, SCCVII, and RIF-1 tumors.
Fine-needle aspirates from tumors in human patients and from mice were treated in the same manner. Single-cell suspensions were prepared by mixing the aspirates into calcium- and magnesium-free phosphate-buffered saline. A mixture of 0.5 ml cell suspension and 1.5 ml of a 1% solution of agarose containing 2% dimethyl sulfoxide was layered onto a microscope slide and allowed to cool on a cold block. For the comet assay [27], slides were placed in a lysis buffer consisting of 30 mM NaOH, 1 M NaCl and 0.1% N-lauroylsarcosine for 60 minutes. After three 20-minute washes in a buffer containing 30 mM NaOH and 2 mM EDTA, the slides were placed in a fresh solution of the same buffer for electrophoresis at 0.6 V/cm for 22 minutes. Thereafter, the slides were rinsed in distilled water for 15 minutes and then stained with propidium iodide (2.5 µg/ml) for 15 minutes. Slides were analyzed with a Nikon Optiphot microscope attached to an Ikegami 4612 CCD camera and fluorescence image analysis system. DNA single-strand breaks were measured using the tail moment parameter, the product of the percentage of DNA in the comet tail and the mean tail length, using specially designed software [28]. A total of 300 cells were scored per sample.
Because we wished to use the alkaline comet assay to compare DNA damage induced by TPZ in transplanted tumors in mice with that induced in tumors in patients, we first obtained preliminary data on the time and dose needed to obtain maximum response in the mouse studies. As can be seen from Figure 1, maximum DNA damage, as assessed by median tail moment, is obtained roughly 30 to 45 minutes after a single intraperitoneal dose of 0.08 mmol/kg TPZ (Figure 1A. We also show that in these RIF-1 tumors DNA damage tends to plateau at doses above 0.08 mmol/kg (Figure 1B), as we previously observed with the SCCVII tumor [21].
Based on these data we chose 45 minutes after a single intraperitoneal dose of 0.08 mmol/kg as the dose and time to measure DNA damage in the four different transplanted tumors chosen for this study. These tumors were selected because we have previously shown that TPZ (0.08 to 0.12 mmol/kg per injection), when combined with each dose of a fractionated irradiation regimen (8x2.5 Gy), produced significant potentiation in all tumors except the human colon carcinoma HT-1080 [16,21]. The extent of potentiation of the two mouse (SCCVII and RIF-1), and the human colon carcinoma HT-29, was by dose modification factors of 1.5 to 1.7 (i.e., equivalent to giving 50% to 70% more radiation dose to the tumors) [21]. However we found no potentiation of the antitumor efficacy of fractionated radiation in the HT-1080 tumors by TPZ [21].
Figure 2 shows the data obtained on tumor oxygenation and on TPZ-induced DNA damage from two patients to illustrate the type of data and the range of the values obtained. We calculated median pO2 for each tumor as well as the median tail moment and 20th and 80th percentile values from the fine-needle aspirates taken immediately before and after the TPZ infusion. We found extensive heterogeneity both in oxygenation within a single tumor as well as between tumors, with median pO2 values for individual tumors varying from 0.8 to 45.2 mm Hg in this series. This variation is much greater than that of transplanted mouse tumors, including those used in this study [22].
Figure 3 shows a summary of the median tail moments obtained from the four different transplanted tumors following a bolus injection of 0.08 mmol/kg TPZ and from the patients following an infusion of 300 to 330 mg/m2 TPZ. According to a recent analysis of total drug exposure in mice and humans [29] these clinical doses should give TPZ exposures approximately double those of the mice. In the case of the mice, a fine-needle aspirate from each of the tumors was taken immediately before and 45 minutes after the TPZ injection. For the patients, DNA damage was measured in aspirates taken immediately before and at the end of the infusion of TPZ given over a 1.5- to 2-hour period.
The data show three important points. First, they show that the one tumor, HT 1080, that shows no potentiation of antitumor efficacy of fractionated radiation by TPZ also has very low levels of TPZ-induced DNA damage. The other three tumors show extensive DNA damage produced by TPZ. Second, all the patients' tumors show TPZ-induced DNA damage that is either comparable to, or greater than, that seen in the mouse tumors. Third, there is much greater interpatient variation in DNA damage induced by TPZ than between individual mouse tumors.
Because oxygen levels of all of the tumors in the clinical trial were measured using the Eppendorf pO2 electrode before randomization (and infusion of TPZ), we were able to test whether the variation in TPZ-induced DNA damage related to tumor oxygenation as has been seen for mouse tumors [21]. We found this to be the case. Patients in the lower half of the range of median tail moments of TPZ damage (i.e., below a median tail moment of 32) had better oxygenated tumors than those with higher levels of damage (mean±SE of median pO2 values=22.5±5.6 mm Hg, n=7, and 5.6±2.3 mm Hg, n=6, for the low-and high-damage groups respectively). The difference between the oxygen levels in the two groups is significant (P=0.02, two-tailed Student's t-test). Figure 4 shows the median tail moment of each tumor following TPZ as a function of the fraction of pO2 values less than 5 mm Hg (the pO2 value below which TPZ cell kill is close to maximum [30]). Although there is considerable scatter in the data (r2=0.32), the trend of increasing DNA damage as a function of tumor hypoxia is significant (P=0.04). A similar level of significance is obtained if the DNA damage data are plotted against median tumor pO2. Because of the extensive heterogeneity in the DNA damage from individual tumors we also analyzed the comet data by percentage of values with a tail moment of >20 because this criterion has been shown by Olive et al. to correlate best with the extent of TPZ-induced cell kill in mouse tumors [20]. However, although this also showed a trend with tumor hypoxia, the correlation was not significant, possibly because this artificially truncates the data at values more than 85% to 90% of values >20.
In this study we show that DNA damage induced in human head and neck tumors by the new anticancer drug tirapazamine is similar to, or greater than, that produced in human and murine tumors transplanted in mice. We have previously shown with these transplanted tumor models that TPZ, at drug and radiation doses comparable to those given clinically, produces a significant tumor-specific enhancement of radiation damage [16,21,31]. This potentiation of radiation damage is the result of TPZ killing the hypoxic (and therefore radiation-resistant) cells in the tumor [16,32]. We and Olive et al. have also shown that TPZ-induced DNA damage measured by the comet assay is closely correlated with TPZ-induced cell kill [19,20], and is therefore a possible surrogate assay for its ability to enhance the efficacy of radiotherapy.
In order for TPZ to improve the outcome of radiotherapy three important criteria must be met. First, the dose of TPZ must be sufficient. Previous measurements of the total drug exposure (area under the curve) for TPZ obtained from Phase I studies have suggested that dose levels predicted to be active in potentiating radiation are reached in the clinic [29,33]. Second, levels of the intranuclear enzyme(s) that metabolize TPZ to produce the DNA damage leading to hypoxic cell kill [34] must be adequate. Up to the present study there have been comparisons of DNA damage and cytotoxicity of human and mouse tumors only with established cell lines in vitro [1,7,19,21]. These studies have suggested that human cells may not be as sensitive to killing by TPZ under hypoxia as are rodent cells [7,19]. Third, human tumors must be sufficiently hypoxic for TPZ activation. Although there is abundant evidence from oxygen electrode measurements that many human tumors have hypoxic regions [3,24,35], we have recently shown, using electrode measurements, that transplanted mouse tumors are significantly more hypoxic than human tumors [22]. Thus, until the present study there was reason to suspect that TPZ might not be as active in human tumors as in mouse tumors.
Assuming that DNA damage measured by the alkaline comet assay correlates with hypoxic cell kill, our data suggest that all three of the above criteria for killing of the hypoxic cells in the tumor are met in these human tumors from patients treated with 300 to 330 mg/m2 of TPZ. These data, therefore, provide support for the hypothesis that TPZ will potentiate radiation therapy in these human head and neck tumors.
The fact that nodes of human head and neck cancers show a wide range of tumor oxygenation [13,24,35,36] allowed us to make a further test of the hypothesis that hypoxia is important for the activation of TPZ. We would expect in our series that there would be a correlation between TPZ damage and tumor hypoxia. This was the case: we found a significant association of TPZ-induced DNA damage with levels of tumor hypoxia. This is expected from our earlier studies of mouse tumors in which we modified tumor oxygenation by the mice breathing different oxygen concentrations. We found that the level of TPZ-induced DNA damage assayed by the alkaline comet assay correlated closely with tumor hypoxia [21]. However, it should be noted that Olive et al. found that with mouse tumors there was too much heterogeneity of damage to distinguish between hypoxic and aerobic cells in tumors on the basis of TPZ-induced damage [20]. This is likely because there is a continuous gradient of oxygen levels in tumors [37] as well as the fact that cell killing by TPZ (and probably DNA damage) is a continuous function of oxygen concentration [30]. It is also apparent from the data of TPZ-induced DNA damage as a function of tumor hypoxia (Figure 4) that, despite the significant trend, there is considerable variability with only 32% of the variation in comet median tail moment being attributable to measured tumor oxygenation. There are multiple possible reasons for this, including the fact that the pO2 probe may overestimate cellular hypoxia by measuring necrotic areas, contamination of the fine-needle aspirates with leukocytes (see below), variable levels of TPZ metabolizing enzymes in the individual tumors, and the fact that DNA damage induced by TPZ could be low in transiently hypoxic cells, the numbers of which could vary between tumors.
Despite these caveats, the present data suggest that the alkaline comet assay has the potential of being a surrogate endpoint for cell kill by agents that produce DNA single strand breaks. The fact that such breaks can be measured both in mouse and human tumors provides a means of assessing whether a particular treatment, or a modifier of treatment, is likely to be effective in human tumors. We have previously demonstrated that stable translocations determined by fluorescence in situ hybridization could be used to predict the efficacy of a modifier of radiation treatment in human tumor xenografts in mice [38]. In the present study we show that DNA damage assessed by the comet assay from a fine-needle aspirate may be able to predict the efficacy of a cancer treatment that produces DNA strand breaks. The assay is extremely useful in this regard, first, because a fine-needle aspirate yields an adequate number of cells for the assay, and second, because by measuring DNA damage in individual cells, heterogeneity in response can be evaluated [28]. Nor is the comet assay limited to assessing anticancer agents that kill cells by forming DNA strand breaks such as radiation or topoisomerase inhibitors [39]. It could theoretically be used for measuring the efficacy of agents that kill cells by forming interstrand crosslinks such as bifunctional alkylating agents or cisplatin [27,40].
One potential problem with the assay, however, is that only in cases in which the DNA content of the tumor cells is markedly different from diploid can normal cells within the tumor be excluded from the analysis. This may not be a problem with normal cells resident in the tumors as Olive et al. have shown that tumor-associated macrophages have a similar distribution of oxygen levels as do tumor cells [28]. However, fine-needle aspirates such as performed here can be contaminated with circulating leukocytes that were not in the tumor during all the time of exposure to TPZ. These may be removed before analysis using magnetic immunobeads coated with antibodies against leukocyte surface antigens [41], but this was not done in the present investigation.
In summary, we show using the alkaline comet assay, which measures DNA single-strand breaks in individual tumor cells, that tirapazamine produces comparable damage in human tumors in patients given tolerated doses of drug as it does with tumors transplanted into mice. This provides encouragement that TPZ may be as effective in potentiating the efficacy of radiotherapy of human head and neck cancers as it is in potentiating fractionated radiation of the majority of transplanted tumors in mice.
1This work was supported by US Public Health Service grant P01 CA 67166.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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This used Vintage set of Callaway Bobby Jones Irons is a set for collectors and or players. With no offset and a small clubface these irons have a clean look at address. The narrow sole with low bounce increases playability from tight lies and reduces drag in long grass. To add stability and feel to these forged irons, they have a bore-through shaft to reduce twisting. Look great on your wall also.
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600w Peak 1200w Dc 12v Modified Wave Power Inverter With Charger Voltage Display - Chinaprice: contact company for price
600W offline UPS dc to ac inverter with battery charger
With Uninterruptible Power Source, Time of fully automatic converting 10ms.
1)600W continuous output power and 1200W surge power.
2)Suitable for mobile AC power used in car, household and industry.
3)High surge power to start difficult loads such as heavy-duty power tools, motor
4)Suitable for most AC-powered electronic equipment including computers, TV, icebox, and more.
5)Enjoy full and stable power with storage battery together.
6)It can save 1/3 charge time with pulse charge, good for saving charge time and high life for storage battery.
7)With Uninterruptible Power Source, Time of fully automatic converting 10ms
8) size: 26.5X15.2X5.5cm, Net weight:2kg
Invert part:
Rated power: 600w
output continuous power: 600w
output peak power: 1200w
DC input voltage: 12V/24V
Working voltage: 11-15V / 21-29V
Low voltage protection: 9V-10.5V / 18.5V-20.5V
Lack voltage alarm: 9.5V-11V/ 19.5V-21V
Over-voltage protection: ≥15V / ≥29V
DC input Fuse: 50A*7
Output wave form: modified sine wave
Output voltage: 110V/120V/220V/230V/240V
Output frequency: 50HZ/60HZ
Reserving efficency: ≥ 85%
Overload protection: 600W-720W
Short circuit protection: YES
Working temperature: -10°c- +50°c
Temperature protection: +60°c - +70°c
Green led indicator: Light(fully charge), flash(charging), extinguish(no AC supply or in AC input voltage protection station)
Charge Part:
Rate Power: 600W
AC output voltage: 110V/120V ; 220V/230V/240V
AC input frequency: 50HZ/60HZ
AC working voltage: 85V-130V / 170V-250V
AC input low voltage protection: ≤75V / ≤150V
AC input high voltage protection: ≥130V / ≥250V
AC input fuse: 10A or 5A
Charge style: intelligent positive and negative pulse charge
Charge process: prep charge. main charge.float charge. charge fully
Charge current: Maximal 10A
Charge voltage: 14.5V-16V / 29V-32V
Switching time from inverter to AC supply:
≤10ms(no need to restart computer when connected to computer
Switching time from AC supply to inverter:
≤10ms( no need to restart computer when connected to computer
Conditional from inverter to AC supply: In the normal AC input voltage
Conditional from AC supply to inverter: No AC input or AC input protection happen
Yellow led indicator:
Light(fully charge), flash(charging), extinguish(no AC supply or in AC input voltage protection station)
Rated power: 1000w
output continuous power: 1000w
output peak power: 2000w
DC input Fuse: 25A*7
Overload protection: 1000W-1200W
Rate Power: 1000W
AC input fuse: 15A or 10A
Charge current: Maximal 5A
Company Contact:
- Posted By: Sun Gold Power Co.,Ltd
- Phone: 8675566632091
- Address: 13F Wangxiangtiancheng Building, Shingping Industr, shenzhen, China
- Email:
- Website: http://www.suninverterups.com/
Published date: September 6, 2013 -
- Business Description: Sun Gold Power Company Established in Shenzhen in 1999, is a
professional manufacturer which produces and develops DC To AC Power
Inverter, grid tie inverter, Uninterrupted Power Supply (UPS ),generator
and other related products. For more than ten years , with a strong R&D
team, internal automation equipment design and manufacturing capability,
as well as continuous quality improvement, we has become the leading
supplier for power energy solution in the new world of information
Our company has a workshop covering more than 8000 square meters. We have more than 500 employees, including more than 20 experienced technicians. At the same time, we have introduced advanced technology from home and abroad positively, improved and refined our products continuously. Years of specialized production has made our products salable in the world market, like Russia, Southeast Asia, Europe, America, the Middle East and Africa.
"Science and technology promote business powerful, while brand make it flourishing" is our management idea, and "building good image for customers at home and abroad" is our responsibility. We'll dedicate ourselves to serving consumers, the society and workers so as to realize mutual benefits. We promise to help you at any time, because "honesty and service are our source of persistent existence and development".
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On Broadway, 'American Psycho' Is a Little Too Sane
Tuesday, April 26, 2016 at 9:30 a.m. by Miriam Felton-Dansky
It's a pretty apt moment for the resurrection of Patrick Bateman: avatar of Reagan-era American arrogance and Eighties Wall Street excess, avid Donald Trump fan, and (debatably) dabbler in serial killing. The antihero of Bret Easton...


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This card case from HUGO boasts distinctively grained leather. The wide smooth leather panel with tone-on-tone topstitching and a small embossed logo complements the design of this men's accessory. A special feature: the money clip on the back.
2 card slots
1 slot compartment
Dimensions: approx. 10 x 7 cm
1 slot compartment
Dimensions: approx. 10 x 7 cm
Material and Care
Material information: 100% Cow skin, Lining: 100% Polyester, Facing: 100% Brass, 100% Calfskin


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Fons Hickmann
Fons Hickmann: Touch Me There
Книгу можно купить в интернет-магазинах:
· OZON.ru 7539р. [Проверить наличие]
ISBN: 389955079XИздательство: Gestalten Verlag
Год издания: 2005
Страниц: 472
Book DescriptionThe Berlin-based studio Fons Hickmann m23 has been a frequent winner of international design awards for years. The company has a reputation among both clients and peers for producing intelligent graphic design that is simultaneously well structured and galvanising. Their work always seeks to transcend existing limits without seeming affected. Touch Me There is the first comprehensive presentation of Fons Hickmann m23?s body of work and demonstrates that sophisticated German graphic design can meld conceptual clarity with a grown-up pop culture sensibility. It features projects ? including those that were never implemented ? from the fields of poster, magazine, corporate and exhibition design as well as guest contributions from authors and artists. The book is bilingual, appearing in both English and German. Touch Me There is structured into eight sections that represent the subject areas relevant to Fons Hickmann and his work: music, philosophy,...
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Corowa, New South Wales, Australia 1902 – Melbourne, Victoria, Australia 1993
Disturbed fowls.
Place made:
Melbourne, Victoria, Australia
Materials & Technique: prints, ink; paper linocut, printed in colour inks, from multiple blocks Support: oriental paper
Manufacturer's Mark: no manufacturer's mark.
Edition State: published state
Impression: 5/80
Edition: edition of 80


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The nation's most commonly reported infections in 1995 were sexually transmitted, and a disease that often has no symptoms topped the list, the Government says.
Chlamydia, tracked for the first time last year, was the most reported infectious disease, with 477,638 cases. Gonorrhea and AIDS were second and third, according to an annual report released on Thursday by the Federal Centers for Disease Control and Prevention.
''It backs up our message about safe sex,'' said Dr. Denise Koo, an epidemiologist for the centers.
Gonorrhea, the most commonly reported disease in 1994, with 418,068 cases, fell to the No. 2 spot last year, with 392,848 cases.
AIDS, which had been No. 2, also dropped, with 71,547 cases reported in 1995, compared with 78,279 cases the year before, the report said.
Those two, plus chlamydia, syphilis and hepatitis B, accounted for 87 percent of the total number of cases caused by the top 10 maladies.
Chlamydia was more commonly reported among women, striking 383,956 last year, while gonorrhea and AIDS were reported more by men, with 203,563 and 58,007 cases.
Untreated chlamydia, an often symptomless infection, can cause infertility and pregnancy complications.
Salmonella poisoning and a painful bowel infection called shigellosis were the most common germs infecting children under 5. Tuberculosis led among people 65 and older.
The centers' annual report relies on numbers compiled by epidemiologists in each state. Every year, the doctors decide which diseases to track. This year they chose 52.
The flu, which the states track voluntarily, was not on the list.Continue reading the main story