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Providence-based Cathedral Development is moving forward with plans to build a 40-unit apartment building on vacant land in Federal Hill. more
By Mary MacDonald
The overall vacancy rate for office space in downtown Providence increased last year, in large part due to consolidation of corporations and some defections to suburban office parks. In addition, the conversion of office buildings to … more
By MARY MACDONALD | email@example.com | 3/11/16
NORTH KINGSTOWN – Although the new multiuse athletic fields located within the Quonset Business Park will open next fall, much work has been completed over the past year, the Quonset Development Corp. announced Dec. 16. Construction of … more
FALL RIVER – The Planning Department will hold a public hearing on a proposed South End Housing Incentive Zone, which would offer state and local tax credits for the development of market-rate housing in old mill buildings in the southern part of … more
Conversion of farmland to residential subdivisions is giving way to a new development pressure, installation of sprawling solar grids. Requests to develop solar fields, or solar farms, have started to mount in Rhode Island, in towns and … more
By Mary MacDonald | email@example.com | 8/4/16 | 1 comment
Lawmakers in Massachusetts are drafting a bill that would jump-start the offshore wind industry in the U.S., helping trigger a $10 billion building spree off the Atlantic coast. more
By Joe Ryan
A newly formed nonprofit corporation, Building Bridges Providence, will host a celebration on Saturday at the site of the city's next downtown park. more
By Mary MacDonald
Ferguson Perforating Co. recently completed a $2 million expansion of its manufacturing facilities, adding nearly 19,000 square feet to the structure. more
By Mary MacDonald
Alexion Pharmaceuticals Inc. is planning a $200 million phased expansion of its manufacturing plant here, to facilitate production of its drug, Soliris, and other products. more
By Mary MacDonald
With a value of $698.1 million, Providence Place mall occupies a unique position in the capital city. It is at once its largest, most valuable commercial property. It also holds its most generous taxpayer subsidy, a 30-year deal that shields it from … more
By Mary MacDonald | email@example.com | 7/7/16 | 1 comment


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Since we last spoke, LELO has gone a bit insane with the new releases. They've now put out the Ina/Mona Wave, [edit: review here!] Siri 2 [edit: review here!], Pino, and PicoBong Transformer. Thoughts on the Mona Wave and Siri 2 are forthcoming. Thoughts on the Pino and Transformer: they're stupid. Je Joue has two new toys, the Nuo butt plug and Dua dual vibe, controlled by remotes that look like pens. OK, I'm down. Laid, a Norwegian company perhaps best known for their silicone cock rings and stone dildos, is trying to make a smart pelvic floor exerciser called Loop. OhMiBod just announced that their Cuddle vibe and Share cock ring will be added to the blueMotion line, making them adjustable . . . read more
Je Joue
Je Joue is a London-based rechargeable sex toy manufacturer. They made the first toy to ever simulate oral sex, the SaSi.
Epiphora's best and worst sex toys of 2011
[Check out my annual best/worst tag for older and newer lists!] It's almost 2012, so you (maybe) know what that means — it's time for me to list my top and bottom toys of 2011! Remember, like last year, this list includes toys that I acquired/reviewed in 2011, not necessarily toys that were released this year. Anyway, let's get to it! Best sex toys of 2011 Vixen Creations Mustang — For the second year in a row, a toy made of VixSkin tops the list. Is it any wonder? VixSkin is so good, anything made out of it is amazing. Even smallish dildos like the Mustang. My vag was definitely surprised. We-Vibe Touch — Finally, a rechargeable clit vibe in a perfectly pointed, scooped . . . read more
Review: MiMi
Everyone's coming out with a cute little rechargeable clitoral stimulator these days. Jimmyjane released the Form 2 and Form 3; LELO invented the Siri and Alia; and now Je Joue has submitted their contribution, the MiMi. None of these has been the perfect clitoral stimulator; they all have issues ranging from mildly irritating (not waterproof) to problematic (shape is weird) to rage-inducing (has a glitch that turns me into a mass murderer). MiMi (can we catch a break on the unnecessary capitalization, plz?) was, at first, on the mildly irritating end of the spectrum. But it slid into rage-inducing when it died on me. Long story short (I put the whole thing on my Tumblr): my first MiMi freaked the fuck . . . read more
Review: Ami
Je Joue, makers of the failtastic SaSi, attempt to make vag balls! In my head, that is the slogan for the Je Joue Ami. Which is really quite unfair to the Ami, because this set of vag balls (kegel exercise balls, if you prefer) is not bad at all. Divorced from the terrible mistake that is the SaSi, the Ami balls are an admirable contribution to the vag ball market. I say "admirable," though, and not "FREAKIN' AWESOME," for a reason. You will see. The Ami set is trying really hard, and I mean that in a loving way. It comes in a box within a box, and it's sealed with plastic (props, Je Joue, I appreciate that). The storage box . . . read more
Review: SaSi
The SaSi is no longer in production. The closest approximation is the LELO Ora. There's also the Womanizer. The Je Joue SaSi is a few years old now, but it's still often touted as one of the most innovative sex toys on the block. It's just like oral sex! It remembers what you like! Look at the rolly-ball go! It's a technological wonder! And yes, the SaSi does look exciting. It features a mechanical ball about the size of a small gumball that moves around underneath a thin layer of 100% silicone. It has a "customize" mode in which the user can skip certain settings and press the "don't stop" button on others. Over time, the toy remembers which settings were favored, . . . read more

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Hyperlite Team CT Wakeboard Bindings 2015
If you are an intermediate to advanced wakeboarder looking to step into a binding with more control and more power, or an accomplished rider looking for a great daily whip, the Hyperlite Team CT Wakeboard Bindings are your workhorse. A closed toe, lasted construction means these bindings will feel more like skate shoes or snowboard boots than wakeboard bindings, and the mid flex and dual density footbed give you just the right amount of support and impact absorption you want, for a performance boot with solid impact absorption and some forgiveness. Up your game in the Team CT Wakeboard Bindings from Hyperlite.
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Pet Setting & Drop Ins in North Domingo Baca, Albuquerque
Book a pet sitter to stop by your home a few times a day to feed and play with your dog.
I love and value all fur babies! :)
Academy Hills Park, Albuquerque, NM, 87111
Dog Boarding, House Sitting, Drop-In Visits, Doggy Day Care, Dog Walking
About: My entire life I have been around rescue dogs and I currently have two rescues of my own. I value the lives of dogs as much as I do humans. To me, ... (more)
Love caring for others in need!
Alta Monte, Albuquerque, NM, 87107
House Sitting, Drop-In Visits, Dog Walking
"Absolutely pleased!! My cats were calm, the litter box was clean, food bowls were full and the water was fresh. Darcel followed my written instructions. She ... (more)"
Reliable Honest Patient Smoochy
Heritage Hills, Albuquerque, NM, 87109
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"Will watched my dog Maggie for me for two weeks when I was traveling. There were not any problems which is amazing because Maggie can be a major pain in the... (more)"
Enthusiastic Animal Lover
Del Norte, Albuquerque, NM, 87109
House Sitting, Drop-In Visits
"Kathryn was great with Basil, my Scottie. Calm, friendly and completely followed what i had asked for. The pic during her visit was definitely the highlight ... (more)"
My dogs are my best friends!
Montgomery Park, Albuquerque, NM, 87110
Dog Boarding, Drop-In Visits, Doggy Day Care, Dog Walking
"Karen did a great job taking care my cat. It was my first time leaving him alone, but her daily texts to me after she checked in on him put me at ease. I fel... (more)"
Animal-lover wants to care for dogs!
Albuquerque, NM, 87110
House Sitting, Drop-In Visits, Dog Walking
"Michelle took care of everything we discussed and communicated with us very well. We loved seeing pictures of our dogs during our vacation. Thank you Miche... (more)"
Love animals as your own childern
Eisenhower, Albuquerque , NM, 87111
Dog Boarding, Drop-In Visits, Doggy Day Care, Dog Walking
"I highly recommend Jessica to anyone regarding their pet she is really good at taking care of my dog when I need her she's always available to give me a hand... (more)"
I will love your pet like my own <3
Bel-Air, Albuquerque, NM, 87110
House Sitting, Drop-In Visits, Dog Walking
"Jennifer's love for animals of any kind makes her the perfect pet sitter. I have 2 cats and 1 crazy black lab and they all adore her! Jennifer has pet sat fo... (more)"
Patient, responsible animal lover
Albuquerque, NM, 87110
Dog Boarding, House Sitting, Drop-In Visits, Dog Walking
"Samantha was a wonderful person to take care of my dog, I went with her because I know how much she loves animals and how much she cares about them. I would ... (more)"
Have Car, Will Pet
Albuquerque, NM, 87111
Drop-In Visits, Dog Walking
"Kate was wonderful, we received a couple of pictures during the visit, and an update on how it all went. We can't wait to use her again! (more)"
I've loved dogs my whole life
Heritage East, ALBUQUERQUE, NM, 87109
House Sitting, Drop-In Visits, Dog Walking
"Morgan has taken care of our dog many times. She is extremely responsible and capable. Her love of dogs is obvious in the way she plays with, talks to, and... (more)"
Playful and energetic!
Heritage Hills, Albuquerque, NM, 87109
House Sitting, Drop-In Visits, Dog Walking
"Francesca did a good job of taking care of my kitten Luna for me! She didn't follow all my instructions to the tee, but I'm happy with how she did. (more)"
Genuine Dog Lover / College Funds
Dog Boarding, House Sitting, Drop-In Visits, Doggy Day Care, Dog Walking
About: My names Daniel! I'm a twenty year-old God fearing, animal loving, and outdoorsy kind of college student, looking to pay for college and my first h... (more)
Fun-loving, friendly dog care!
San Antonio, Albuquerque, NM, 87109
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"She may have never gone through with her childhood dream of becoming a veterinarian, but the sentiment certainly has followed her! Heather cares for animals,... (more)"
Pet sitter/walker extraordinaire
Del Rey R, Albuquerque, NM, 87109
Drop-In Visits, Dog Walking
About: I grew up with dogs and am always so happy to have them as a part of my life. I've watched my parents and friends dogs for them countless times whi... (more)
Playing is mandatory
N Albuquerque Acres, Albuquerque , NM, 87122
Drop-In Visits, Dog Walking
About: I grew up with dogs (mostly German shepherds with the golden retriever or terrier thrown in there). My husband is not a dog person, but I love them... (more)
Experience exceptional service and a personalized match
From start to finish, we'll handle all the details for you.Learn About Premier
Rover also offers pet setting & drop ins in these other Albuquerque neighborhoods:
|Broadway Central
|Encanto Village
|Ladera West
|N Campus
|Netherwood Park
|North Four Hills
|Quail Ridge
|Rio Grande Blvd
|Sandia Ridge
The next time you head out of town and need someone to take care of your pets and check in on you home, turn to Rover. It's easy to find a loving North Domingo Baca pet sitter on Rover who'll give your pet one-on-one attention while you're away, and take care of your home. Search from hundreds of trusted pet sitters in North Domingo Baca, Albuquerque, read sitter profiles, and reach out to sitters who seem like a good fit for you and your pet(s). We know it can be tough to leave your pet, which is why we encourage every pet parent and sitter to have a Meet & Greet before booking the stay. Then, when you're ready, book and pay for your house and pet sitter all through Rover: it's easy, safe, and cashless. You'll have the peace of mind knowing that your sitter has free premium insurance, a team of safety experts available 24/7, and will send you cute photo updates throughout the stay. Rover is the easiest way to find trustworthy North Domingo Baca pet sitters and avoid the kennel.
A Daily Treat: A Blog by Rover
Rover's got you covered, even when you don't need a pet sitter or dog walker. Check out our blog for pictures of adorable dogs, help on your biggest dog-related questions, and more:
- Top 100 Dog Names and Unique Dog Names, depending on your preference
- Hot Weather Dogs: Tips for Keeping Your Canine Cool
- 5 Tips to Help Your Partner Fall in Love with Your Dog
Book a Stay, Donate to a Cause
Sit a Dog, Save a Life lets you raise money for local dogs-in-need by doing something you do already: asking your neighbors to watch your dog instead of leaving them in a kennel. Many Rover sitters in North Domingo Baca, Albuquerque donate a percentage of their earnings to nonprofits through Sit a Dog, Save a Life. When you book with a sitter who has the Rover Donation Badge on their profile, you're helping dogs in need, right here in Albuquerque.
We're proud to support over 200 organizations across the nation, including:


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US Swimmer and Beijing relay gold medalist Ricky Berens tore the back of his swimsuit in a qualifying heat of the 4x100m relay freestyle on Sunday during the World Swimming Championships in Rome. Shortly before stepping up to the starting block, the University of Texas senior leaned down to stretch and his suit tore.
"I kind of freaked out for just a second," Berens said. "I felt like [the hole] was almost down to my knees. I felt like I was putting on a pretty good show."
He did. And the US qualified for finals and won. Photos of Michael Phelps and the victory here.
HuffPost Entertainment is your one-stop shop for celebrity news, hilarious late-night bits, industry and awards coverage and more — sent right to your inbox six days a week. Learn more


text:
Review of Dirty Bomb powered by the Slant community.
Steam RatingMostly Positive
GenreHero-based FPS
Ranked in these QuestionsQuestion Ranking
Pro Objective focused FPS
Game is an objective focus FPS, much like Team Fortress 2. It requires team work to win the game.
Pro Free to play
The game is free to play
Much like other free to play games, this game has problems in paying to skip ahead of other players. Such as character unlocks and buying load out chests.


text:
The Song of Songs - Chapter 1
The Song of Songs Chapters
2 BELOVED: Let him kiss me with the kisses of his mouth, for your love-making is sweeter than wine;
3 delicate is the fragrance of your perfume, your name is an oil poured out, and that is why girls love you.
4 Draw me in your footsteps, let us run. The king has brought me into his rooms; you will be our joy and our gladness. We shall praise your love more than wine; how right it is to love you.
5 BELOVED: I am black but lovely, daughters of Jerusalem, like the tents of Kedar, like the pavilions of Salmah.
6 Take no notice of my dark colouring, it is the sun that has burnt me. My mother's sons turned their anger on me, they made me look after the vineyards. My own vineyard I had not looked after!
7 Tell me then, sweetheart, where will you lead your flock to graze, where will you rest it at noon? That I may no more wander like a vagabond beside the flocks of your companions.
8 CHORUS: If you do not know this, O loveliest of women, follow the tracks of the flock, and take your kids to graze close by the shepherds' tents.
9 LOVER: I compare you, my love, to my mare harnessed to Pharaoh's chariot.
10 Your cheeks show fair between their pendants and your neck within its necklaces.
11 We shall make you golden earrings and beads of silver.
12 DUO: -While the king rests in his own room my nard yields its perfume.
13 My love is a sachet of myrrh lying between my breasts.
14 My love is a cluster of henna flowers among the vines of En-Gedi.
15 -How beautiful you are, my beloved, how beautiful you are! Your eyes are doves.
16 -How beautiful you are, my love, and how you delight me! Our bed is the greensward.
17 -The beams of our house are cedar trees, its panelling the cypress.
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Reading 1, Sirach 6:5-17: 5 A kindly turn of speech attracts new friends, a courteous ... Responsorial Psalm, Psalms 119:12, 16, 18, 27, 34, 35: 12 Blessed are you, Yahweh, teach ... Gospel, Mark 10:1-12: 1 After leaving there, he came into the territory of Judaea and ... continue readingMore Daily Readings
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The New Jerusalem Bible (NJB) is a Catholic translation of the Bible published in 1985. The New Jerusalem Bible (NJB) has become the most widely used Roman Catholic Bible outside of the United States. It has the imprimatur of Cardinal George Basil Hume.
Like its predecessor, the Jerusalem Bible, the New Jerusalem Bible (NJB) version is translated "directly from the Hebrew, Greek or Aramaic." The 1973 French translation, the Bible de Jerusalem, is followed only "where the text admits to more than one interpretation." Introductions and notes, with some modifications, are taken from the Bible de Jerusalem.
Source: The Very Reverend Dom (Joseph) Henry Wansbrough, OSB, MA (Oxon), STL (Fribourg), LSS (Rome), a monk of Ampleforth Abbey and a biblical scholar. He was General Editor of the New Jerusalem Bible. "New Jerusalem Bible, Regular Edition", pg. v.
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You may be under the impression that fishing is an exclusive sport, requiring high-end equipment. But with only a couple of pounds spent on shop-bought items and a bit of knowledge, you can create an effective – if basic – rod and tackle.
A fishing pole is best made from a thin, standing-dead hazel sapling – lighter than green wood but less likely to be rotten than fallen branches. Snap or saw the tallest one you can find close to the base in order to maximize the overall length (ideally around three or four metres). The length allows you to lower bait in specific areas, and reach the best "swims". The odd kink here and there doesn't matter, but remove any twigs or burs.
Now find a large feather to make a float – goose or swan are best. Trim away the feathers so only the central quill remains and cut off the thinner top end so the whole thing measures 15cm. Hold this up to the light and you will see the air chamber at the bottom. This gives the float its buoyancy. In order to attach this to a line, you need to fold the solid top third of the quill over on itself. Do this by hollowing out a centimetre-wide groove at the fold point, being careful not to work all the way through. Bending the top third over should then form an "eyelet", which your fishing line can be fed through. If it does, tie the folded end down. If not, hollow out more until you see the hole.
Nylon fishing line, a hook and a couple of small weights can be bought cheaply in any tackle or outdoor sports shop. The length of line required depends on the depth of the river, but you want a metre between rod tip and float and then whatever will leave your hook about 7cm above the river bottom. Attach the weights so they are equally spaced between the hook and the float.
We tried our homemade rod on the river Teifi in Wales, which wound its way through the terrain like a ribbon, the bright morning gleaming across its polished surface. Wading through grass, comfrey and nettles, we negotiated a crumbling bank, our hazel rods handily doubling as walking sticks.
Our best bet lay on the margins where the water was still, beef-stock brown and ruffled only by a gentle eddy bobbling back upstream. We swung out our bait, a worm dug from the adjoining meadow, and settled down to wait.
Fishing requires total silence. Amid this calm, time starts to slip away downstream. Hours fly by as if minutes, our eyes drawn to the hypnotic movement of a float drifting at the whim of the river's time. Breathing becomes deeper, the muscles relax and the mind empties. Fishing is meditation, even if we don't realise it. The rod a conduit for the angler's skills and knowledge, an extension of ourselves that allows us to commune with the water and its banks. The more personal it is, the closer we get.
And what banks. On this wildlife-crammed stretch of river, blue-tailed damselflies appeared to dance where rays lit the water. Evening fell on a scene so entrancing that neither of us reacted when the rod tip moved. The hazel jumped again and this time we both dived for the pole. A flash of silver near the surface, a flapping jolt and the sapling flexed as we lifted our catch.
Just 10cm long, the young wild brown trout seemed as big as the white whale in our eyes, and we quickly removed the hook from the corner of its mouth. Under his russet flanks and gold spots, a slow heartbeat, surprisingly powerful in the palm. We looked into its unblinking eye before lowering it back into the river. With a splash, it was gone.
Time spent fashioning a rod and fishing brought an important connection. Below the surface, our rivers, lakes and ponds are fascinating places. From pike to rudd, grayling to minnow, dynasties exist in and around these hidden worlds, but ones we rarely get to see. Fishing draws us closer. Although some may feel it is an invasion, we found catching our fish to be a reminder of the importance of their preservation.
Places to test your tackle
Fishing in saltwater is free, but anglers need a rod licence for freshwater in England and Wales. Day (£3.75) and seasonal licences (under-12s free; 12 to 16 £5; adults £27) can be bought online at environment-agency.gov.uk; the money is reinvested in protecting our river ecosystems.
* The Maltsters Arms, Tuckenhay, Devon
Keith Floyd's old pub is a wonderful place to try out your homemade rod. Overlooking Bow Creek, a tributary of the Dart, the banks are rich with flora and fauna. Owner George Welsh is happy to point out the spots to catch red mullet and sea bass. Should you return empty handed, he will entertain you into the wee hours with conciliatory pints. B&B from £85. www.tuckenhay.com.
* Bullock Farm Campsite, Somerset
Close to the coastal, countryside village of Kingston Seymour near Bristol, this campsite lets you roll out a tent pretty much adjacent to its five freshwater lakes for just £5. Brimming with fish, this angler's idyll was recently voted in the top 50 fisheries in the UK by both the Angler's Mail and the Angling Times. bullockfarm.co.uk.
* Sleningford Watermill Caravan & Camping, Ripon, Yorkshire
Spend peaceful nights under canvas in the beautiful surroundings of this old watermill and wildlife hotspot and long days on the picturesque stretches of the River Ure, which weaves majestically nearby through verdant countryside (pitches from £17). sleningfordwatermill.co.uk
* Bartles Lodge B&B, Dereham, Norfolk
In the sleepy village of Elsing, Chris and Jane offer cosy bed and breakfast accommodation situated in 11 acres of beautiful grounds. Wander with your DIY rod to any of the three well-stocked fishing lakes. A little farther away, the river Wensum winds its way through villages and countryside where there are also day ticket stretches available. B&B from £62.Reuse content


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It improves the body's response to insulin, which promotes healthy blood sugar levels. Prevents inflammation, especially in the brain tissue and helps cope with pain in general. It cleans digestion related infections, improves metabolism and helps treat yeast infections. It can also aid weight loss by metabolizing sugars and suppressing your cravings.
Modern research indicates that cinnamon may have some very beneficial properties. According to the U.S. National Library of Medicine, Cinnamon is used to help treat muscle spasms, vomiting, diarrhea, infections, the common cold, loss of appetite, and erectile dysfunction (ED).The use of cinnamon for medicinal reasons is becoming an increasingly popular natural health practice for several reasons
Medicinal Benefits of Cinnamon:
Lowering Blood Sugar:
Individuals that have difficulty with their blood sugar levels, particularly diabetics, have used cinnamon because it helps the body respond to insulin more effectively, which encourages healthy blood sugar levels.
Reducing Inflammation:
Studies have found that the cinnamon actually helped prevent inflammation in brain tissue. This secures a longer and healthier life for your brain.
[Read: Benefits of Honey And Cinnamon]
Helping Digestion:
Cinnamon uses the antibacterial properties to help infected digestive tracts and promote the healthy breakdown of food. It also has been shown to ease symptoms of bloating, prevent nausea, help digest dairy, and treat diarrhoea.
Treating Yeast Infections:
Treating yeast infections is one of the most effective medical benefits that comes from cinnamon. Trials have shown that it had the ability to prevent the infection from developing even when it became resistant to medication.
Reducing Weight:
Cinnamon can also help you achieve your goals with weight loss (cinnamon is also one of the ingredients in my weight loss drink). It increases the circulation of blood, which leads to a faster metabolic rate. It also keeps hunger at bay by metabolizing sugars and suppressing cravings.
Reducing Pain:
Cinnamon can effectively keep away prostaglandins, which are receptors that make your neurons more sensitive to pain. The large amount of manganese also helps encourage bone health and prevent pain brought on by arthritis.
add with lemon?
pity you could't use a picture of cinnamon in this article. this is cassia!
Where can get some to buy in Ghana?
hai,, what can we do form headache?
I love cinnamon! & drink cinnamon tea every day with some cloves!!CHEERS!!
I use a lot of ceylon cinnamon daily.
Recently read a article about Cassia which looks like cinnamon & widely selling in India and other countries but can be very dangerous for health . Sharing a link below "how to recognize original cinnamon & why Cassia is not good for your health " http://www.thenewsminute.com/article/buying-cinnamon-store-watch-out-its-dangerous-lookalike-cassia-34781
Hw much n how to be used??
It is indeed useful and healthy :)
Yes it does :)
This is casiam ; fake cinnamon from China
This is a very good article,I didn't know cinnamon was so useful for keeping the body healthy .
Very good article. The usage for cinnamon is growing, and for an all positive effect on the human body. Sharing
Ayurveda does the commonly available Indian cinnamon also aid weight loss ?
Isko hindi me dalcheni boltei h kya?
I heard is was an afradesiac(not sure how to spell that) for men???
It is an article about the spice. Thank you for your suggestion, we could include it the next time
This isn't specific about the use of the oil.


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Eas Sensormatic Mk75i Hand Detacher For Gator Tag - Chinaprice: contact company for price
The MK75I Hand Detacher manually removes Gator type hard tags
(i.e. Ultra*Gator and MicroGator) from merchandise.
The detacher includes a lanyard to secure it to the
checkstand. The detacher contains a concealed label that will
set off Ultra•Max systems if someone attempts to remove it
from the store.
Eas Sensormatic Mk75i Hand Detacher For Gator Tag
Please see our contact information below
Company Contact:
- Posted By: Virginland Technology Co., Ltd
- Phone: 862061309993
- Address: Room 832, No.120, Yanling Road, Tianhe Dist., Guan, Guangzhou, China
- Email:
- Website: http://www.trusttag.com
Published date: September 12, 2013 -
- Business Description: Established in 1998, Guangzhou Virginland Technology Co., Limited is one
manufacturer in China, specialized in retail loss prevention industry
with a wide variety of accessories to Electronic Article Surveillance
(EAS ) systems, such as acousto magnetic or EM (magnetic) or radio
frequency hard tags, labels, lanyards, detachers, pins,etc.
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- This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"


text:
Molecular Mechanisms in Legionella Pathogenesis
ISBN/ASIN: 9783642405907,9783642405914 | 2013 | English | pdf | 295/297 pages | 3.68 Mb
Publisher: Springer-Verlag Berlin Heidelberg | Author: Pedro Escoll, Monica Rolando (auth.), Hubert Hilbi (eds.) | Edition: 1
Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.


text:
Constraints and Creativity
The Psychology of Breakthrough
By (author) Patricia Stokes
Format: Paperback
Normal Price: $113.00
Your Price: $101.70 AUD, inc. GST
Shipping: $7.95 per order
You Save: $11.30! (10% off normal price)
Plus...earn $5.09 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
Constraints and Creativity by Patricia Stokes
Book DescriptionIn this exciting new contribution to the study of creativity, psychologist, artist, and writer Dr. Patricia Stokes delves into the minds of famous creative artists and discovers the surprising source leading to their creative breakthroughs. From Picasso to Stravinsky, Kundera to Chanel, to Frank Lloyd Wright, it is not boundary-less creative freedom that inspires new ideas, but self-imposed, well-considered constraints. Monet forced himself to repeatedly paint the way light broke on, between, and around his subjects, contrasting color instead of light and dark, and softening edges in the process. His constraints catapulted the art world from representational to impressionist art. Whatever your creative field-be you an artist, educator, or psychologist who studies creativity and problem solving - Stokes shows you how to think clearly about your creative development and design the vital constraints that will take you to breakthrough.
Buy Constraints and Creativity book by Patricia Stokes from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780826178459
(230mm x 154mm x 10mm)
Pages: 168
Imprint: Springer Publishing Co Inc
Publisher: Springer Publishing Co Inc
Publish Date: 31-Aug-2005
Country of Publication: United States
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text:
Sports & Recreation, ProfessionalFollow
|Sports & Recreation
NBA Lockdown covers all of the latest news, rumors and opinions with ESPN's team of experts.
February 23rd, 2016
Episode 195 of 309 episodes
Jorge Sedano and Tom Haberstroh weigh in on the impact of the Grizzlies losing Marc Gasol for the season, debate if Draymond Green is the best center in the league and more.
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


text: I love this ministry. I'm a high school baseball coach and resource teacher, and I'm also the FCA sponsor. Many people are passionate about sports and FCA helps people become passionate about Jesus. FCA is the only Christian club in our school. Do any of you have any thoughts on the Fellowship of Christian Athletes?


text:
Eclipse™ Ella Beaded Blackout Window Panel & Valance - Sold Seperately- Online Only
Experience the darkness, silence and beauty of Eclipse curtains. Eclipse blackout panels have been laboratory-tested to block out over 99% of intrusive light, unwanted noise, and can help save on home heating and cooling costs.
Transform your media room into the ultimate home theater experience, or create ambiance in your dining area. National Sleep Foundation studies show that reduced light and noise are optimal for a better night's sleep. Eclipse Curtains are perfect for the bedroom, kid's room or nursery, providing the ideal sleep environment for the whole family.
The magic is in the Thermaweave construction. The innovative triple-weave design allows you to enjoy all of the light-blocking, noise-reducing and energy-saving benefits, while providing the same fashionable style and elegance of naturally flowing curtains. This soft, plush fabric has an elegant texture with a subtle sheen and is available several colors.
Window Panel: Hang two or more curtain panels on a standard or decorative rod for optimal coverage and desired effect. Sold as a single panel, measuring 52-in. wide in your choice of 63-in., 84-in., or 95-in. lengths. Panel can be hung as rod-pocket or back tab.
Valance: Sold as a single rod pocket valance measuring 52-in. wide by 18-in. long.
- Window panel: 52-in. W, your choice of 63-in. L, 84-in. L or 95-in. L
- Valance: 52-in. W x 18-in. L
- Rod sold separately
- Polyester
- Machine wash gentle cycle; tumble dry. Do not bleach.
- Imported
Scroll down to see all available products in this collection and to make your selections.
Shipping & Returns
Shipping your purchase is easy on belk.com. Depending on the destination of your package, you can expect it to arrive within 4-7 business days. Shipping Information
Returns are easy on belk.com. Easy returns


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Is Spn Management Consultants incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
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Hotfrog Singapore provides information regarding Spn Management Consultants in Singapore. Spn Management Consultants is located at 1 North Bridge Rd High St Centre #07-10 High Street Centre, Singapore and provides Business services. Contact them on 6338 9175 or by visiting them on their website http://www.spn.com.sg.
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Little country church
December 22, 2007
It's just a little country church. But for those few left who grew up in the mostly vanished community of Inez, memories of Christmas gatherings and summers with "dinner-on-the-grounds" linger.
The memories and the little church itself may...
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text:
[Nexxxt Generation] Dressed Up Teens 2 (2014) [WEBRip 720p]
Here you will find fresh porn videos, movies for every taste. You can download their by clicking on the link site file-sharing service Nitroflare, Uploaded, Gigapeta, Keep2Share.cc and many other.
Dressed Up Teens 2 begins with the lovely Angelline, giving her lover a blowjob, before getting her pussy fucked. Gabriella Gash has her pantyhose torn open, before swallowing a facial and the drop dead gorgeous Dona, will be showing you her tight asshole and bubble butt before you see Crystal Crown having her shaved pussy licked and finally, Dona and Evita Fine will both get facials!
Original Name: Dressed Up Teens 2
Year: 2014
Genre: One On One, Big Boobs, 18+ Teen, Facial Cumshot, Lingerie, Brunette, Blonde, Red Head
Studio: Nexxxt Generation
Starring: Gabriella, Monika, Mona, Michele, Angelline
Duration: 02:01:10
Quality: WEB-DL 720p
Format: MP4
Video: MPEG4 Video (H264) 1280x720 30fps 5489kbps [Video]
Audio: AAC 44100Hz stereo 127kbps [Audio]
Size: 4.96 GB
Users of Guests are not allowed to comment this publication.


text:
Buttery Pan Roasted Mushrooms and Asparagus
Total Time
Prep 10 mins
Cook 10 mins
The name says it all! My favorite way to serve mushrooms and asparagus. Quick, easy, and delicious.
Ingredients Nutrition
- 1⁄2 small onion, sliced thinly
- 1 1⁄2 cups fresh mushrooms, sliced
- 1 1⁄2 cups asparagus, 1 inch chopped tips and most tender parts
- 3 -4 tablespoons butter (no substitutions)
- salt and pepper
- In a heavy frying pan (I like cast iron)cook onion and butter on med-high to high heat until onion is tender.
- Add mushrooms and cook until they start to brown, stirring often.
- Add asparagus, salt, and pepper to taste and cook until crisp-tender. This dish is best when the asparagus is still a bit crisp and bright green. Serve hot.
Most Helpful
Excellent and simple, however I think adding shallots and garlic add quite a bit. I also think that using bouillon helps with the flavor, but all of those do add complexity. Great recipe either way.
It is really easy and tasty recepie. Thanks
I really liked this!! Made in my cast iron skillet and let it cook low and slow. Everything turned out the perfect tenderness and went well with my salmon and gratin potatoes. Will be making this again! Made for The Best of 2012 Cookbook Tag.


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Hotels in Pierrefeu-du-Var
Hotel reservation
Hotel rooms in Pierrefeu-du-Var
There are not so many hotel rooms in Pierrefeu-du-Var, just 3, still everyone can find an offer to suit his choice. The most common offers in this city are hotels, they count 1 out of 3, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the south of Pierrefeu-du-Var, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Pierrefeu-du-Var. The most populated with hotels district of Pierrefeu-du-Var is the center, 50% of cheap hotel rooms are concentrated here. However, even those who want to live in the north can choose from 1 variants of hotel rooms. Pierrefeu-du-Var is a truly multifaceted city, here everyone can find a hotel of his choice: a business person, a young couple or a family with little children. Take a look at our selection of the cheap hotel rooms in Pierrefeu-du-Var to make a well-informed choice for your reservation!
Pierrefeu-du-Var cheap hotels
Guest Houses
All cheap hotels in Pierrefeu-du-Var
Best hotels in Pierrefeu-du-Var
Hotels in Pierrefeu-du-Var are spread around the city within the distance of 2.2 kilometers, while 2 hotels are located directly in the city center. The most popular accommodations in Pierrefeu-du-Var is
Domaine de la Broquiere
located in a 2.1 kilometers from the city center.
The best hotels are here and now. Try them!
All cities in France


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|Download your favorite shows for free - Upload new shows to be added to this website
|Click the link on top of every tour page to go to the subfolder of the Stack cloud that contains all the bootlegs of that tour. Select your favorite bootleg by clicking the check mark on the left and download it for free.
|New shows can be uploaded here: https://yessongs3.stackstorage.com/index.php/s/drR9mFOkqn9X8Xz
To upload new material you open the first empty folder. Use the UPLOAD button or simply drag the files into that empty Stack folder. Note: your uploads or messages can be seen by others as well.
|Anderson Rabin Wakeman - An Evening Of Yes Music & More - 2016 - 2017 tours
|I got many questions from fans for a special page with ARW recordings. I decided to add this page indeed.
I didn't add a thumbnail link to the ARW page on top of every page, the only link is the picture on the left.
Why .....? I know ABWH is amongst those tours as well, but ABWH is generally seen as Yes in contrast to ARW which can't be seen as Yes because there is an active band Yes at the moment. However, it is so much like the ancient Yes that it really deserves to be part of this website and my collection.
|What's new this month?
Sorry, no updates this month due to a serious server crash.
Next month new shows and covers will be added as usual.
On the tour pages the new shows and covers from last month are still marked with
|About this website Launched: 2010 - 08 - 07 - Collection update: 2017 - 01 - 01
|- Owner of this website is: Remy (1958)
- This website is fully dedicated to the progressive rock band YES
- It contains only unofficially released material, mostly recordings of live shows they did in more than 45 years
- The links above will lead you through my collection of Yes bootlegs which will be updated every month
- The rating of every show is just my personal opinion!
- All tracks are listed (incl. length, played with WinAmp) so you can compare your shows with mine
- All shows can be downloaded from the Stack cloud by clicking on top of every tour page
- This website has been tested only for Internet Explorer 7, 8 and Google Chrome
- If you find any information on this site that is not correct, please tell me
|Buy, sell & trade Yes(-related) material
|Searching for 'original' Yes bootlegs, vinyl records, tourbooks or other Yes memorabilia? Or want to sell or trade some material? This could be the place to make your request or place your advertisement. Send your request or advertisement to me and I will place it on this website.
Click on the picture on the left to check the advertisements.
Of course there are some rules if you want to advertise:
|Links to other Yes sites


text:
Archive for December, 2010
Happy New Year!
Entirely unrelated to the new year, here's a fascinating video for any fans of comedy (especially those who grew up watching the golden age of SNL in the '90s).
Star Wars: Revenge of the Sith Movie Review (111 Minutes)
Part 1:
Part 2:
Part 3:
Got another 70 minutes to kill? See also:
Star Wars: The Phantom Menace Movie Review (70 Minutes Long)
MSNBC – Many Snickering Nonentities Berating Conservatives
In the clip below, an obnoxious MSNBC guest host harrasses the chairman of GOProud for being a gay man who identifies as a conservative Republican.
This is a particularly egregious example of the way MSNBC approaches broadcasting: a giggling liberal assured of his own moral superiority makes reductionist arguments about his opponent's position while completely avoiding gigantic frontiers of substantive debate.
The GOProud chairman takes the bait a few times but otherwise does an excellent job exposing the host as a condescending, closed-minded prick who did not bother to conduct even cursory research of his guest or the organization he represents. (Watch the exchange at about 2:10.)
Visit msnbc.com for breaking news, world news, and news about the economy
From The Right Scoop via Drew M. at Ace of Spades HQ.
Vampire Government – Police State Trial Balloons?
"No refusal" drunk driving checkpoints: the government will take a blood sample, for the crime of driving on New Year's Eve. Of course, that's only if you "opt out" of the breath test.
The latest trend in state run checkpoints — sure, you don't have to subject yourself to our illegal search, but if you don't we'll do something much worse.
An intelligent case against the criminalization of drunk driving. It's time to rethink where we're drawing the line concerning violations of our constitutional rights.
The right of the people to be secure in their persons, houses, papers, and effects, against unreasonable searches and seizures, shall not be violated, and no Warrants shall issue, but upon probable cause, supported by Oath or affirmation, and particularly describing the place to be searched, and the persons or things to be seized. (like your blood)
(If you can name the amendment, you probably are not a product of our public school system…or care enough to have educated yourself)
I Hate Celebrities…
And evidently so does British critic David Thomson, Editor of The Biographical Dictionary Of Film. The Daily Mail has excerpts and this one is my favorite:
MATT DAMON: What's most interesting about Damon is the very lack of good looks– and the feeling of a squashed and rebuilt face.
Matt Damon's strident, leftist politics are really annoying, too, but Thomson is correct– above all, Matt Damon has a weird face.
Taking camouflage to a new level
This is some of the most creative art I've seen in a long time.
Also, proof that we will someday have Predator-style invisibility suits…
More here, or look up Liu Bolin on Google (images).
A PC Dilemma
At Obama's press conference today, a reporter wished him "Feliz Navidad".
If you listened closely, you could hear the Harvard-forged synapses firing in his political correctness calculator:
PC points for responding with a perfectly inflected "Feliz Navidad":Â 120
PC point loss for referencing Christmas where your atheist comrades can hear: 50
Net PC gain/loss:Â +70
He went with a "Feliz Navidad", and a shout out to his illegal amigos…
An Inconvenient Solution in the "Fight" Against Unemployment
America is sometimes referred to as "the Saudi Arabia of coal", or "the Saudi Arabia of natural gas". It might be more accurate to refer to Saudi Arabia as "the America of oil". The coal industry has been an important part of our country for many generations. Coal mining can provide a very good living for people willing to work hard at a dirty, dangerous job. But right now, with politicians hunting around for jobs like they're a leprechaun's pot of gold at the end of the rainbow, the EPA is attempting to regulate coal burning power plants and the coal industry at large out of existence. And all without any input from Congress — the will of the people seems to keep getting in the way of "progress".
"We need more jobs, we need more exports to China to level the trade imbalance!" cry politicians. Meanwhile, an Australian company signed a $60 billion contract to export coal to China, and China is still suffering a coal shortage. Our government is sending a clear message that here in America, if your job in the energy industry doesn't involve tending a windmill farm or fixing broken solar panels, it's morally bankrupt and just not moving us forward into a brave new energy future.


text:
need writers 2 (Spanish, German, Japanese, Turkish)
This project was awarded to karenquintero for $3 USD / hour.Get free quotes for a project like this
Project Budget$2 - $8 USD / hour
Total Bids14
Project Description
Need some article writer for different language.......i need some Spanish, Japan, Russian, Turkish and German writer. Who have good knowledge on English...
I am willing to pay 4$ per 500 words....
Those who bid on this project please attach a sample any one on these(Spanish, Russian and German) languages.
i will create milestone for the winning Writer....
Looking for long term relationship....
Awarded to:
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
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Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
All Connectivity Development Articles
Designing with wired or wireless networks for M2M and other embedded designs and the protocols to use.
All Connectivity Development Articles
Taming erratic cellular latency with "extreme asynchronous" IoT firmware design
Incorporating a self-contained cellular module into an IoT device's design has many advantages,... Read More
Bluetooth low energy (BLE) fundamentals
Bluetooth low energy the intelligent, power-friendly version of Bluetooth wireless technology... Read More
RS-485 meets high-speed requirements in industrial systems
RS-485 is the chosen physical layer standard for numerous industrial communication systems. Here... Read More
10 Things NOT to do when embedding a web server
HTTP is the most common protocol but small devices can't simply handle all that we want them to... Read More
Simplifying universal serial bus connectivity with USB bridge devices
There's a no-hassle approach for adding USB to any embedded solution, with no need for USB... Read More
Embedded email
Here's an approach that enables some quite imaginative functionality to be added to devices with... Read More
Standards light the way in enterprise IoT
Open standard-based wireless lighting control systems are a catalyst ushering building controls... Read More
Top considerations before starting your IoT design project
Online suppliers offer myriad connectivity solutions, but developers are often hesitant to adopt... Read More
Using an embedded Web server
Optimized for embedded applications, an HTTP server is likely to be quite small in terms of code... Read More
IPv6 - a beginner's guide
One of the myths associated with IPv6 is that the only reason to adopt IPv6 is the impending... Read More
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text:
Optimum Freight Solutions Pty Ltd
Logistics, Transport logistics, Freight Forwarding
Whether you are importing or exporting by air or sea, we able to offer extensive services to assist you along the way. Some of our Clearing and Forwarding activities amongst others are detailed below:
Free comprehensive quotations for full logistics services covering in-bound and out -bound sea, road and airfreight consignments.
Registration service/assistance for first-time importers and exporters with SARS
Customs mediation and applications for Tariff Determinations and other customs related matters
Specialised documentary requirements undertaken for legalisation of shipping documentation
Comprehensive insurance options underwritten by Lloyds of London
Regular and accurate status reporting on the progress of your shipments up to final delivery.
Customs clearing and forwarding
Print this page
National & Cross Border Transport Services
Extensive sea freight import and export services
Warehousing Services in Bayhead Durban
Airfreight import and export rates worldwide
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text:
Patrons at a downtown Toronto pub may have done a double take on Friday night when pop star Justin Bieber sat down at the piano and played a few songs.
Fifth Pubhouse, located at Richmond Street West east of John Street, issued a news release Sunday saying Bieber wandered in alone, ordered a drink and watched the Toronto Raptors' game.
The pub says he spied a piano and asked staff if he could play it.
A few posted YouTube videos captured the impromptu performance.
According to the pub's news release, Bieber played a number of songs including the Beatles Let it Be and his own song Sorry. He also play a few bars of Beethoven's Fur Elise.
Pub owner Oliver Geddes says the Canadian pop star was gracious to both staff and customers at the entertainment district bar.


text:
Arts, Food, Games & Hobbies, HobbiesFollow
Basic Brewing Radio is a weekly show about the basics of brewing beer in your own home. We take the mystery and fear out of brewing the best beer in the world. Look for our podcast in the iTunes Music Store - it's free!
March 6th, 2008
Episode 135 of 554 episodes
Italian home brewer and beer podcaster Tony Manzi gives us a virtual tour of the beer and home brewing scene in his country.
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


text:
For those wanting to know more about Chesapeake Bay Retrievers in the UK
The Chesapeake Bay Retriever Club has been bringing British Chesapeake enthusiasts together since 1983. The Club holds two gundog working tests each year, as well as a championship show. Other events include obedience workshops, dog and gun days, training days and breed seminars. Members are kept informed of Club news via a magazine - the Chessie Chat - which is sent out three times a year.
The club show is usually held in the Midlands, while the working tests move around the UK. We have held tests in Hampshire, on the marshes of the Essex coastline, in South Wales and in the Angus Glens of Scotland - plus many locations in between! As members may be travelling a long way to take part in the working tests, we often make a weekend of it. It's good to get together with other brown dogs and their owners.
Most people who have lived with a Chesapeake will usually consider having no other breed. If you are reading this, maybe you are trying to work out whether a Chesapeake is right for you. This website will hopefully help you to decide. We will give you some basic information about the breed, and list some events where you can meet Chesapeakes and talk to their owners.
Optigen are now offering better than ever discounts off DNA tests. If you are thinking of having your dog DNA tested, you can get a discounted price at Val Tiller's postal Optigen 20/20 Clinic, shipping 22nd February. Chessies are invited to be DNA tested for prcd-PRA, DM, EIC and Curly. For full details, and test kits, contact Val now at firstname.lastname@example.com or telephone (01372) 273597.
Sunday 26 February 2017
Meeting begins at 10.30 am
(Tea/coffee available 10.00–10.30 am)
Long Lawford Memorial Hall, Long Lawford, nr Rugby CV23 9BA
Directions: From Rugby, take the A428 Rugby to Coventry road. About half a mile past Rugby Cement Works turn right at the Sheaf and Sickle pub crossroads into Back Lane. Follow it, and turn left almost immediately after the railway bridge. Straight on, and the hall is on your right in Railway Street.
According to club rules, half the committee retires annually. The committee members retiring in 2017 are as follows:
Dave Lowther is standing down. Chris, Jason and Dave are willing to stand for re-election. There are five vacancies on the committee. The Hon Secretary, Hon Treasurer and Chairman retire annually. All are willing to stand for re-election.
Items for the agenda and nominations (in writing) for Committee, Secretary, Treasurer and Chairman of the Club, signed by both proposer and seconder, must be with the Secretary by 29 January.
The 2016 AGM minutes will be printed in the forthcoming Chat issue. Copies of the agenda and minutes of the last AGM will be available at the meeting or by prior request to the Secretary.
The Club's perpetual trophies for various categories will be awarded at the AGM in February. Would those interested in putting their dogs or themselves forward, please fill in the appropriate forms, i.e. working, show or dual purpose, and then email or send to Chrissie Mayhew, Dumpford Manor Farm, Trotton, Petersfield, Hampshire GU31 5JR or email email@example.com BY 12TH FEBRUARY AT THE LATEST. Nominations are also needed for the best CHAT article for 2016. The forms for the points can be downloaded here:
Don't forget that all members' annual subscriptions are due on 1 January every year. See the membership page for more details.
The Club will be holding a breed seminar on Chesapeake Bay Retrievers in February. This is both for judges and for anyone wanting to learn more about the breed. For more information and a downloadable booking form, see the Events page. *Please note, the judging assessment in the afternoon is now FULLY BOOKED. You can still book a place on the breed seminar in the morning, but please do not try to book a place on the judging assessment in the afternoon.*
For the latest update on the Give a Dog a Genome Project, take a look on the Give a Dog a Genome project website pages.
This autumn's Chesapeake Bay Retriever Club Working Test was held on the marshes in Essex. It was a brilliant location for the test, and we are very grateful to the Dengie One Hundred Wildfowlers for letting us use the ground, as well as to the very generous hospitality of Richard Playle and Tilly Thomas for letting us invade their home for the whole weekend. Catharina and Kaj Lindstrom travelled over from Sweden to judge the test, and also helped with the training day on Saturday. We had several people travel over from Europe to run their Chesapeakes in the test. Full details will be in the next Chessie Chat issue.
Give a Dog a Genome is a new initiative launched by the Kennel Club Genetics Centre at the Animal Health Trust that will create the UK's largest canine genome bank to help generations of dogs. This genome bank will improve dog health by radically increasing our understanding of the canine genome. The project aims to sequence the entire genomes (all 2.4 billion letters of DNA) of 50 different dog breeds by the end of 2016. The KC Charitable Trust have donated £50,000 to the project. The cost of sequencing one genome is £2000. The AHT is appealing to dog breed communities to donate £1000 towards the cost of their breed being included in the project. In return, the breed will represent one of the 50 genomes sequenced and will help to make a significant contribution to the future of canine genetics research.
There is lots more information on the Give a Dog a Genome pages of the Animal Health Trust website.
Thanks to the generous donations of our Chesapeake lovers in the UK and abroad, we managed to raise the £1000 required in just a couple of days. THANK YOU! There will be updates posted here as the project progresses.
All members' subs are due on 1 January every year. Single membership £10. Joint membership £12. Overseas membership £15.
Please note that the old Bank of Scotland club account closed on 1 Feb 2016. If you have paid into the Bank of Scotland account until now, please ensure you have cancel this standing order, and replace it with a NatWest standing order. For more information, contact the Treasurer, Sandy Hastings on 01507 568028.
Here are the results of the Chesapeake health survey that many of you contributed to early in 2014. The aim of this first survey was to identify what problems exist in the breed, and determine how common the problems are. The results show that Chesapeakes are a generally healthy breed, with similar conditions to the general dog population, particularly other large, active breeds. Future surveys will look at the most serious and common conditions in more detail, and see how they relate to lifestyle, methods of rearing, vaccinations, etc. Thanks to everyone who took part in this survey.
Please note that the CBRC does not have a Facebook page. Any comments and opinions that appear on Facebook belong to individuals, and in no way represent the Chesapeake Bay Retriever Club.
There are a few team events each year where we are invited to run a team of Chesapeakes in inter-breed working tests. If you would like your dog to be considered for the team, please contact Jason Mayhew on 07808 518000.
We also get asked to have Chesapeakes available in the Discover Dogs section of Crufts, KC events and at various game fairs each year. If you have a friendly dog that enjoys being patted by the public all day long, and you would like to play your part in representing the breed, please get in touch with Molly Barker (01427 890578 or email@example.com). She is always looking for volunteers!
Mark Greenhough, Wildfowling Officer for BASC, and his Chesapeake Echo star in a second BASC film, this time an introduction to wildfowling. An Introduction to Wildfowling appears on the BASC homepage: www.basc.org.uk.
Mark Greenhough's Echo is the star of BASC's latest online video. The Long Retrieve features Echo retrieving a mallard across the Dee Estuary. It appears on the BASC homepage: www.basc.org.uk.
Copies of test certificates issued by OFA are now sent directly to the KC, where the test result will be added to the dog's details on the registration database. This will trigger the publication of the test result in the next available Breed Records Supplement. The result will also appear on any new registration certificate issued for the dog and on the registration certificates of any future progeny of the dog. It will be available via the KC's health test result finder.


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text: A Couple Found an Abandoned Girl on the Street. What They Did after That Is Changing Many Lives. Shreya Pareek September 14, 2015 Andhra Pradesh, Children, Orphans "It's not an orphanage. It's a children's home and we are their parents. We are their family and we make sure we do the best we can for them," says Shobha Kumar about a very special place called Spandana.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Oct 15, 1985
|Filing date
|Dec 20, 1982
|Priority date
|Dec 18, 1981
|Fee status
|Also published as
|Publication number
|Heinrich Pfeiffer, Wolfgang Muetzel, Ulrich Speck
|Original Assignee
|Schering, Aktiengesellschaft
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (12), Non-Patent Citations (1), Referenced by (15), Classifications (21), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates to new X-ray contrast agents.
Iodine-containing, water-soluble X-ray contrast media are utilized for urography, angiography, myelography, gastrography, computerized tomography, and digital radiography. Additionally, there are other body cavities whose imaging is desired, such as, for example, the articular cavity, the bile duct, the bladder, and the pancreatic duct. It has been clearly apparent for some time that a single X-ray contrast medium cannot satisfy the requirements of such a large number of applications.
Use of the presently available X-ray contrast media is precluded for certain indications, or at least leaves much to be desired, for various reasons, e.g., due to inadequate compatibility in one or another respect, insufficient solubility, concentration, unsuitable pharmacokinetic properties, etc.
Substantial progress has been made with regard to the compatibility of these compounds by the development of nonionic X-ray contrast media in place of the heretofore known ionic contrast media. Special properties of these new media include low painfulness in angiography, small effects on the circulation, and small epileptogenic effect. The clinical experience gained in the meantime with nonionic and readily water-soluble X-ray contrast media (see, e.g., B. Hammer and W. Lackner: "Iopamidol, a New Non-Ionic Hydrosoluble Contrast Medium for Neuroradiology"; Neuroradiology 19:119-121, 1980) showed, on the other hand, that even the most recent opacifying compounds, among which are, for example, iopamidol, metrizamide, and iohexol, still are not devoid of side effects.
Therefore, it is an object of this invention to provide new non-ionic X-ray contrast media possessing, in addition to the required physicochemical characteristics, such as, above all, good water solubility and stability under sterilization conditions, a further improved neural compatibility, and, as well to overcome or ameliorate the mentioned disadvantages.
Upon further study of the specification and appended claims, further objects and advantages of this invention will become apparent to those skilled in the art.
These objects have been attained by this invention by providing novel N-hydroxyethylated 2,4,6-triiodoaminoisophthalic acid bistrihydroxybutylamides of Formula (I) ##STR2## wherein R is trihydroxybutyl.
Suitable trihydroxybutyl groups as R include all isomers and enantiomers of any butyl group, i.e., containing 4 carbon atoms, such as, for example, the 2,3,4-trihydroxybutyl groups, 1,1,1-trishydroxymethylmethyl, the erythro and threo forms of 1,3,4-trihydroxybutyl, etc.
By structural modification of conventional contrast medium compounds from DOS No. 2,726,196, (or U.S. Pat. No. 4,250,113), surprisingly, it has been possible to provide novel triiodinated 5-aminoisophthalic acid bisamides having superior neural compatibility, and which exhibit additional advantages with respect to numerous properties critical for utilization of X-ray contrast media. Especially important is the reduction in the undesirable lipophilic properties of the novel contrast media, obtained by voluminous, extremely hydrophilic substituents. Such a reduction in lipophilicity enables an extremely good general compatibility manifesting itself in a higher LD50 upon i.v. injection in animals, and in a diminished frequency of nausea and allergy-like reactions in clinical usage.
Further surprising and advantageous is the fact that the introduction of voluminous substituents in the triiodo aromatic of Formula (I) does not result in a rise in viscosity. This would have made the utilization of the compounds of this invention very problematic.
In Table I, the following compounds are compared with respect to neural and general compatibility:
A1 =5-[N-(2-Hydroxyethyl)acetylamino]-2,4,6-triiodoisophthalic acid bis(threo-1,3,4-trihydroxybut-2-yl)diamide
A2 =5-[N-(2-Hydroxyethyl)acetylamino]-2,4,6-triiodoisophthalic acid bis(erythro-1,3,4-trihydroxybut-2-yl)diamide
B=Metrizamide (DOS No. 2,031,724 or U.S. Pat. No. 3,701,771)
C=Iopamidol (DOS No. 2,547,789 or U.S. Pat. No. 4,001,323)
D=Iohexol (DOS No. 2,726,196 or U.S. Pat. No. 4,250,113)
TABLE I__________________________________________________________________________Compound A1 A2 B C D__________________________________________________________________________Neural compatibilityRat, pericerebral ED50 171 188 62 154 83mg I/kg (122-207) (142-265) (54-72) (123-216) (60-123)Rat, intracisternal ED50 130 130 48 116 67mg I/kg (39-61) (95-157) (58-88)General compatibility 17 22 14 15 15Mouse LD50 (g I/kg)Iodine content (%) 45 45 48 49 46Number of hydroxy groups/ 7 7 4 5 6moleculeViscosity (mPa � s) 37� C. 5.8 6.2 6.2 4.5 5.5300 mg I/ml__________________________________________________________________________
It can be seen from the data of Table I that compounds A1 and A2 are superior to the comparison compounds with respect to neural as well as general compatibility.
The compounds of this invention can be conventionally sterilized in a suitable preparation by heating to 120� C. The low viscosity of these solutions permits rapid injection.
Because of their good pharmacological properties, the novel compounds of Formula (I) are excellently suitable as opacifying compounds in all fields of application of water-soluble X-ray contrast media for intravenous administration, especially for angiography, urography, myelography, and computerized tomography. Since the novel X-ray contrast media are not absorbed, they are also suitable for oral administration, for example to visualize the gastrointestinal tract.
Consequently, the invention also relates to novel X-ray contrast media based on compounds of Formula (I).
The novel X-ray contrast media based on the compounds of this invention can be produced conventionally, for example by bringing the opacifying compound into a form suitable for intravenous administration together with the additives customary in galenic pharmacy, e.g., stabilizers, such as sodium edetate, calcium disodium edetate, physiologically acceptable buffers, and the like. The concentration of the novel X-ray contrast media in the aqueous medium is dependent on the conventional requirements of the method of X-ray diagnostics employed. The preferred concentrations of the novel compounds usually range from 50 to 400 mg I/ml and the preferred unit dosages are usually from 2 to 500 ml. Concentrations of 100 to 400 mg I/ml are especially preferred. Unless specified otherwise herein, the use and administration of the X-ray contrast media of this invention is fully conventional and analogous, e.g., to that of the conventional X-ray contrast agent, metrizamide , Iopamidol, Diatrizoate, Iohexol.
The present invention furthermore concerns a process for the preparation of compounds of Formula (I), comprising conventionally N-alkylating a compound of Formula (II) in the 5-position ##STR3## wherein R' is the same as R defined above, but free hydroxy groups present in the molecule can be in the blocked form, using a compound of Formula III ##STR4## wherein A and B combined represent the oxygen atom of an oxido ring, or
B is an hydroxy group and
A is a chlorine, sulfate or C1-2 -alkyl sulfate, phenyl or tosyl sulfate, and, optionally, subsequently liberating blocked hydroxy groups.
The N-alkylation of the 5-acylamino group according to this invention is conducted by means of methods known to those skilled in the art. Thus, the compounds of Formula (II) can be reacted, for example, in a suitable solvent, such as methanol, ethanol, or 1,2-propanediol in the presence of an alkali metal alcoholate or alkali metal amide with the compound of Formula (III), for example with chloroethanol or ethylene oxide, at a temperature of from room temperature to 80� C., preferably 20�-60� C.
The alkylation can also be conducted by using the compound II with intermediarily blocked hydroxy groups. In this case, the conventional blocking of the hydroxy groups in the form of a ketal, acetal, ortho ester, or triphenylmethyl ether either has taken place as early as during the production of the preliminary products, or is effected only prior to the reaction of this invention. This step takes place according to customary methods by the introduction of groups which can be readily split off, for example by etherification (e.g., introduction of the triphenylmethyl ether). The blocking of the hydroxy groups can also be achieved by ketalization or acetalization, for example with acetaldehyde, acetone, or dihydropyran.
The subsequent cleavage of the intermediarily introduced blocking groups, with liberation of the ultimately desired hydroxy groups, likewise takes place according to methods generally known to those skilled in the art. Thus, the cleavage of the blocking groups can be effected without a separate reaction stage together with the working up and isolation of the reaction products. However, such cleavage can also be accomplished in the usual way in a separate reaction step. Acyl blocking groups can be split off, for example, by alkaline hydrolysis, and acetal, ketal, or ether blocking groups by acidic hydrolysis.
The starting compounds of Formula (II) are, in part, known, such as, for example 5-acetylamino-2,4,6-triiodoisophthalic acid bis(threo-1,3,4-trihydroxybut-2-yl)diamide (European patent application No. 0,033,426), or they can be prepared pursuant to methods known to persons skilled in the art. The starting material is the conventional 5-acetylamino-2,4,6-triiodoisophthalic acid dichloride (see U.S. Pat. Nos. 3,701,771 and 4,021,481 (Compound No. 11 of Table 4 and 5) and European application No. 0,033,426, whose entire disclosure is incorporated by reference herein). Dissolved in a suitable aprotic solvent, such as dimethylacetamide for example, it can be reacted with the desired aminobutanetriol of Formula (IV)
R' has the same meaning as defined for R, but several of the hydroxy groups can be present in the blocked form.
The aminobutanetriols of Formula (IV) necessary for the above-described reaction are, in part, known, such as, for example, 1,1,1-trishydroxymethylmethylamine, D,L-erythro-2-amino-1,3,4-trihydroxybutane, cis-2,2-dimethyl-6-hydroxy-5-amino-1,3-dioxepane, or they can be prepared according to methods known to those skilled in the art, such as, for example, analogously to the preparation of 2-amino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol, which can be obtained as follows. (In this regard, see commonly assigned U.S. application Ser. No. 451,375 of Dec. 20, 1982 filed on even date, whose entire disclosure is incorporated by reference herein.)
Prepared according to the directions by W. Reppe et al., Liebigs Ann. Chem. 596 : 137 (1955).
Yield: 272 g (97% of theory)
C4 H9 ClO3 (140.568): Calculated: 34.18% C, 6.45% H, 25.22% Cl; Found: 34.07% C, 6.58% H, 25.07% Cl.
258 ml of 2,2-dimethoxypropane is added dropwise within 2 hours to an agitated and water-cooled solution of 272 g of 3-chloro-1,2,4-butanetriol and 0.5 ml of concen-trated sulfuric acid in one liter of acetone. The reaction is completed after another 4 hours. The solution is neutralized by adding 3.8 g of barium hydroxide. The mixture is stirred for another 30 minutes, filtered off from the solid matter, and evaporated to dryness under vacuum, producing 2-chloro-2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol as a yellow oil.
Yield: 340 g (94% of theory).
340 g of 2-chloro-2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol is dissolved in 1.5 1 of absolute ether. At 5� C., 130 g of pulverized potassium hydroxide in total is added within 30 minutes under intensive agitation, the temperature being maintained at between 5� and 15� C. by cooling. The refrigerating bath is then exchanged for a water bath (40� C.), and the suspension is heated for 2 hours under gentle refluxing. After heater and cooler have been turned off, the phases begin to separate. After standing overnight, the mixture is vacuum-filtered over kieselguhr/sand. The residue is extracted with ether. The combined ether solutions are concentrated over a 60 cm Vigreux column. The residue (260 g) is distilled under vacuum, thus obtaining 180 g of a colorless liquid, which is fractionated, yielding 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethylene oxide at 65� C./13 mm. Yield: 154.3 g (57% of theory).
As a by-product, 10.8 g (4% of theory) of 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane is obtained (bp13 :81� C.).
A solution of 73.4 g of 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethylene oxide in 400 ml of 25% strength ammonia is heated in an autoclave for 4 hours to 130� C. The slightly yellowish solution is concentrated to dryness under vacuum; during this step, the residue crystallizes. 2-Amino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol is re-crystallized from ethanol/ether, mp 94�-96� C.
Yield: 52.8 g (64.2% of theory).
The starting compounds of Formula (II) can be prepared according to the following general method:
Within 15 minutes, a solution of 51 g (80 mmol) of 5-acetylamino-2,4,6-triiodoisophthalic acid dichloride (DOS No. 2,031,724) in 100 ml of dimethylacetamide is added dropwise under slight cooling and agitation at room temperature to a solution or suspension of 180 mmol of free or blocked aminobutanetriol of general Formula IV in 100 ml of dimethyl-acetamide. Then 25.1 ml (180 mmol) of triethylamine is added dropwise. After agitation overnight, the suspension is heated for 4 hours to 50� C., thereafter cooled and acidified with 4.5 ml of aqueous concentrated hydrochloric acid. After several hours, the thus-precipitated triethylamine hydrochloride (about 22 g, 90% of theory) is vacuum filtered, and the filtrate is extensively concentrated under vacuum. The product is combined with 200 ml of water and 4 ml of aqueous concentrated sodium hydroxide solution (pH about 10) and stirred for several hours. During this aqueous-acidic and aqueous alkaline treatment, any blocking groups present in the amide residues are generally split off quantitatively. Otherwise, more vigorous conditions must be chosen, or other customary splitting-off methods must be employed. If the bisamide of general Formula II is not precipitated from the aqueous solution, the latter is treated with a cation ex-changer and optionally with an anion exchanger. For purposes of additional purification, the isolated product can also be boiled with ethanol.
The following compounds are obtained according to the foregoing general procedure:
Yield: 51.8 g (80.4% of theory); mp 258�-260� C. (decomposition). In accordance with EP 0,033,426: mp 246�-247� C. and yield 55% of theory.
Yield: 39 g (61% of theory); mp 275�-276� C. (decomposition), using 180 mmol of D,L-erythro-2-amino-1,3,4-trihydroxybutane [Kiss et al., Helv. Chim. Acta 37 : 1471 (1954)]or 180 mmol of cis-2,2-dimethyl-6-hydroxy-5-amino-1,3-dioxepane (R. Ranganathan, M. Sovak, Abstracts of Papers, 182nd ACS National Meeting 1981).
Yield: 47.8 g (74% of theory); mp 279�-283� C. (decomposition), using 180 mmol of 2-amino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol.
Yield: 23.5 g (36.4% of theory); mp 166�-170� C. (decomposition), using 180 mmol of trishydroxymethylmethyl-amine. In a deviation from the general directions, trishydroxymethylmethylamine is likewise used in place of triethylamine, and the reaction mixture is heated for 4 days to 50� C.
Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. In the following examples, all temperatures are set forth uncorrected in degrees Celsius; unless otherwise indicated, all parts and percentages are by weight.
A methylate solution from 100 ml of methanol and 2.48 g (108 mmol) of sodium is combined with 110 ml of 1,2-propylene glycol, 40.4 g (50 mmol) of 5-acetylamino-2,4,6-triiodoisophthalic acid bis(threo-1,3,4-trihydroxybut-2-yl)-diamide, and, for additional washing, with 50 ml of methanol. Under agitation and heating to 50� C., a solution is formed from which the methanol is distilled off under vacuum. The solution is then combined with 6.7 ml (100 mmol) of 2-chloroethanol and further stirred for 5 hours at 50� C. After cooling, the suspension is combined with one liter of acetone and filtered after one hour. The precipitate, which contains sodium chloride, is again extracted under agitation with acetone and vacuum-filtered. This mixture (about 47 g) is dissolved in 470 ml of water and passed over a column with 600 ml of action exchanger IR 120. The aqueous eluate is extensively concentrated under vacuum, the residue is taken up in 370 ml of water and treated analogously with the anion exchanger IRA 140 and worked up. Extraction of the residue by boiling with 165 ml of isopropanol yields 24.6 g (57.7% of theory) of the title compound, mp 250�-254� C. (decomposition).
Iodine, calculated 44.73%, found 44.1%.
100 ml of water dissolves more than 70 g.
Analogously to Example 1, 40.3 g (50 mmol) of 5-acetylamino-2,4,6-triiodoisophthalic acid bis(erythro-1,3,4-trihydroxybut-2-yl)diamide is hydroxyethylated and worked up.
Yield after refluxing with isopropanol: 22.6 g (53.2% of theory) of title compound, mp 292�-296� C. (decomposition).
Iodine, calculated 44.73%, found 44.3%.
100 ml of water dissolves more than 70 g.
Analogously to Example 1, 40.3 g (50 mmol) of 5-acetylamino-2,4,6-triiodoisophthalic acid bis(1,1,1-trishydroxymethylmethyl)diamide is hydroxyethylated and worked up.
Yield after refluxing with isopropanol: 23.7 g (56.9% of theory) of title compound, mp 212�-218� C. (decomposition).
Iodine, calculated 44.73%, found 44.2%.
100 ml of water dissolves more than 70 g.
Analogously to Example 1, 40.3 g (50 mmol) of 5-acetylamino-2,4,6-triiodoisophthalic acid bis(2,3,4-trihydroxybut-1-yl)diamide is hydroxyethylated and worked up.
Yield after refluxing with isopropanol: 27.6 g (64.7% of theory) of title compound, mp 283�-287� C. (decomposition).
Iodine, calculated 44.7%, found 44 2%.
100 ml of water dissolves more than 70 g.
______________________________________5-[N--(2-Hydroxyethyl)acetylamino]-2,4,6- 71.5 gtriiodoisophthalic acid bis(threo-1,3,4-trihydroxybut-2-yl)diamideCalcium disodium edetate 0.01 g2-Amino-2-(hydroxymethyl)-1,3- 0.12 gpropanediol2N Hydrochloric acid to adjust to pH 7.1Double-distilled water ad 100 ml______________________________________
The solution is filled into ampoules or multivials and sterilized at 120� C.
______________________________________5-[N--(2-Hydroxyethyl)acetylamino]-2,4,6- 85.1 gtriiodoisophthalic acid bis(erythro-1,3,4-trihydroxybut-2-yl)diamide2-Amino-2-(hydroxymethyl)-1,3-propanediol 0.12 gCalcium disodium edetate 0.01 g2N Hydrochloric acid to adjust to pH 7.1Double-distilled water ad 100 ml______________________________________
The solution is filled into ampoules or multivials and sterilized at 120� C.
______________________________________5-[N--(2-Hydroxyethyl)acetylamino]-2,4,6- 85.1 gtriiodoisophthalic acid bis(1,1,1-tris-hydroxymethylmethyl)diamideCalcium disodium edetate 0.01 gAnise oil 0.14 gPolyoxyethylene sorbitan oleate 0.75 gDouble-distilled water ad 100 ml______________________________________
The preceding examples can be repeated with similar success by substituting the generically or specifically described reactants and/or operating conditions of this invention for those used in the preceding examples.
From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.
|Cited Patent
|Filing date
|Publication date
|Jun 26, 1970
|Oct 31, 1972
|Nyegaard & Co As
|N-(2,4,6-triiodobenzoyl)-sugar amines
|Nov 24, 1975
|Jan 4, 1977
|Savac Ag
|Water-soluble, non-ionizing hydroxy-containing amide derivatives of 2,4,6-triiodo-isophthalic acid
|Dec 2, 1974
|May 3, 1977
|Nyegaard & Co. A/S
|Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
|Apr 12, 1976
|Jan 17, 1978
|Mallinckrodt, Inc.
|Substituted 2,4,6-triiodoisophthalamic acids
|Aug 24, 1979
|Feb 10, 1981
|Nyegaard & Co. A/S
|Chemical compounds
|Apr 17, 1980
|Jul 27, 1982
|The Regents Of The University Of California
|Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
|Jul 30, 1980
|Oct 5, 1982
|Bracco Industria Chimica S.P.A.
|Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these
|Mar 6, 1980
|Dec 21, 1982
|Schering, Aktiengesellschaft
|Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
|Feb 10, 1981
|Aug 2, 1983
|Nyegaard & Co. A/S
|Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer
|Jan 11, 1982
|Aug 2, 1983
|Mallinckrodt, Inc.
|Triiodoisophthalamide X-ray contrast agent
|Dec 30, 1980
|Aug 12, 1981
|The Regents Of The University Of California
|Triiodobenzoyl derivatives useful as non-ionic contrast media and amino-dioxepane intermediates for their synthesis
|Title not available
|Citing Patent
|Filing date
|Publication date
|Jul 1, 1988
|Sep 4, 1990
|Cook Imaging Corporation
|Non-ionic polyol contrast media from ionic contrast media
|Sep 14, 1990
|Jul 30, 1991
|Cook Imaging Corporation
|Non-ionic contrast media from ionic contrast media
|May 20, 1988
|Nov 19, 1991
|Bracco Industria Chemica S.P.A.
|Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives
|Jun 25, 1992
|Apr 20, 1993
|Nycomed Imaging As
|X-ray contrast agent
|Oct 22, 1993
|Nov 8, 1994
|Zambon Group S.P.A.
|Process for the preparation of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalic acid dichloride
|Mar 4, 1994
|Jan 31, 1995
|Mallinckrodt Medical, Inc.
|Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging
|Feb 22, 1993
|Mar 11, 1997
|Guerbet S A.
|Compounds which can be used in contrast products for radiography
|Jun 5, 1995
|Dec 16, 1997
|Schering Aktiengesellschaft
|Carboxamide non-ionic contrast media
|Mar 19, 1991
|Nov 9, 1999
|Schering Aktiengellsellschaft
|1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
|Jul 23, 1999
|Jun 4, 2002
|Schering Aktiengesellschaft
|1,4,7,10-Tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
|Apr 9, 2002
|Oct 4, 2005
|Schering Ag
|1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
|Apr 9, 2002
|Nov 28, 2002
|Johannes Platzek
|1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
|Sep 26, 2005
|Apr 13, 2006
|Johannes Platzek
|1,4,7,10-Tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
|Aug 1, 1986
|Feb 12, 1987
|Cook Imaging, Inc.
|Non-ionic polyol contrast media from ionic contrast media
|Apr 5, 2012
|Oct 11, 2012
|Universitetet I Oslo
|Agents for medical radar diagnosis
|U.S. Classification
|424/9.454, 564/153
|International Classification
|Cooperative Classification
|European Classification
|Dec 20, 1982
Owner name: SCHERING, AKTIENGESELLSCHAFT, BERLIN AND BERGKAMEN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:PFEIFFER, HEINRICH;MUETZEL, WOLFGANG;SPECK, ULRICH;REEL/FRAME:004078/0999
Effective date: 19821206
|Mar 16, 1989
|Fee payment
Year of fee payment: 4
|Mar 12, 1993
|Fee payment
Year of fee payment: 8
|Mar 17, 1997
|Fee payment
Year of fee payment: 12


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Disha Patani Makes Heads Turn As She Goes Topless for Daboo Ratnani's Calendar Shoot
Image courtesy: Disha's official Instagram account
Mumbai: Actress Disha Patani, who ventured into Bollywood with 2016 biopic M.S. Dhoni: The Untold Story, has posed topless for popular photographer Dabboo Ratnanis annual calendar.
Disha took to Twitter on Wednesday to share a photograph of herself from the photoshoot.
Makeup #jose
Hair #shanky ❤
🙏🏻 Photographer @DabbooRatnani 😊 pic.twitter.com/LGJaNBnHdX
— Disha Patani (@DishPatani) January 11, 2017
In the photograph, Disha can be seen sitting with her left leg upfront, while covering her modesty with her hands. In the image, she is only wearing black underwear and boots.
"Dabboo Ratnani calendar 2017, Makeup - Jose, Hair - Shanky, Photographer - Daboo Ratnani," she captioned the image.
In all, the calendar features 24 celebrities including Amitabh Bachchan, Shah Rukh Khan, Hrithik Roshan, Abhishek Bachchan, Aishwarya Rai Bachchan, Ranveer Singh, Akshay Kumar, Priyanka Chopra, Vidya Balan, Alia Bhatt, Farhan Akhtar, Arjun Rampal, Varun Dhawan, Siddharth Malhotra, Tiger Shroff, Parineeti Chopra, Sonakshi Sinha, Sunny Leone, Sanjay Dutt, Anushka Sharma, Jacqueline Fernandez, Shraddha Kapoor, Kriti Sanon.
On the film front, Disha is currently gearing up for the release of her forthcoming film "Kung Fu Yoga", which will also star legendary actor Jackie Chan. In the film, which is slated to release on January 28 next year, Disha will be seen playing an archaeologist.
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text:
Sound, sensible advice from a hero to frustrated investors everywhere
William Bernstein's The Four Pillars of Investing gives investors the tools they need to construct top-returning portfolios--without the help of a financial adviser. In a relaxed, nonthreatening style, Dr. Bernstein provides a distinctive blend of market history, investing theory, and behavioral finance, one designed to help every investor become more self-sufficient and make better-informed investment decisions. The 4 Pillars of Investing explains how any investor can build a solid foundation for investing by focusing on four essential lessons, each building upon the other. Containing all of the tools needed to achieve investing success, without the help of a financial advisor, it presents:
"synopsis" may belong to another edition of this title.
"A TRIUMPH! Bill Bernstein's new book offers sound principles, unvarnished history, and unmatched understanding of the process of successful investing. It is my candidate for the best investment book of 2002."--John C. Bogle, Founder and Former Chairman, The Vanguard Group, Author, John Bogle on Investing
William Bernstein has carved out a reputation as one of the most brutally honest, yet consistently accurate, voices in today's financial wilderness. In The Four Pillars of Investing, Dr. Bernstein explains how any independent investor can construct a superior investment portfolio by learning these four essentials:
From the essential soundness of classic portfolio theory through the inherent wisdom of investing in multiple asset classes, The Four Pillars of Investing focuses on the four fundamental topics that every investor must understand--and presents an easy-to-follow, step-by-step program for achieving long-term investing success.
"Bernstein is little known. But that's changing, and the sooner you get to know him, the better off your retirement portfolio is likely to be."--Robert Barker, Columnist, BusinessWeek
William Bernstein's first book--The Intelligent Asset Allocator--remains one of the most honored investment books of recent times. Hailed by national publications, including BusinessWeek, and by independent investment icons, including Vanguard founder John Bogle, it has become an instant classic for its well-researched analyses and rules for successful investing.
Now, in the commonsense investor's guide The Four Pillars of Investing, Bernstein returns with the knowledge and tools investors need to assemble low-risk, winning portfolios without professional advice. This down-to-earth book lays out in easy-to-understand prose the four essential topics that every investor must master--the relationship of risk and reward, the history of the market, the psychology of the investor and the market, and the folly of taking financial advice from investment salespeople. It pulls back the curtain to reveal what really goes on in today's financial industry as it outlines a simple program for building wealth while controlling risk.
Straightforward in its presentation and generous in its real-life examples, The Four Pillars of Investing presents a no-nonsense discussion of:
Investing is not a destination. It is a journey, lined with stockbrokers, journalists, and mutual fund companies whose interests are diametrically opposed to yours. The Four Pillars of Investing shows you how, with relatively little effort, you can determine your own financial direction and assemble an investment program with the sole goal of building long-term wealth for yourself and your family.About the Author:
William Bernstein, Ph.D., M.D., has become a grassroots hero to independent investors everywhere. He has made a name for himself by questioning the value of Wall Street wisdom, skewering the recommendations of self-serving stockbrokers, and showing legions of investors how to successfully manage their own investments with intelligence and long-term vision. Bernstein is the author of The Intelligent Asset Allocator, editor of the quarterly asset allocation journal Efficient Frontier, founder of the popular website EfficientFrontier.com, and a principal in Efficient Frontier Advisors. He is often quoted in national publications, including The Wall Street Journal, Barron's, Money, and Forbes.
"About this title" may belong to another edition of this title.
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Book Description McGraw-Hill, 2002. Hardcover. Book Condition: New. New item. Bookseller Inventory # QX-132-09-8996008
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