text:
|Publication number
|Publication type
|Application number
|Publication date
|Oct 30, 2001
|Filing date
|Jan 27, 1999
|Priority date
|Jan 27, 1999
|Fee status
|Also published as
|Publication number
|Marian L. Larson, Eugene A. Larson
|Original Assignee
|Marian L. Larson, Eugene A. Larson
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (13), Referenced by (91), Classifications (13), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to the local delivery of drugs in vivo into the cardiovascular system and other body regions. In particular, the present invention is directed to the local delivery of drugs by applying a coating of a bioabsorbable/biodegradable or inert, in vivo biocompatible conformal film, to an implantable medical device.
Angioplasty is a procedure that involves placing and inflating a balloon catheter in the blood vessel in the area of blockage, which breaks up the accumulated plaque and opens the vessel. While this technique works well in the short term, current literature indicates that 30 to 50% of all angioplasty operations performed will need follow-up treatment within six months. This is due to incomplete plaque removal and the formation of scar tissue as a result of irritation of the blood vessel, known as restenosis. Restenosis results in significant morbidity and mortality and often necessitates further interventions such as repeat angioplasty , coronary bypass, laser surgery or local drug delivery. There has been a focused effort in the health-care industry over the last few years to combat restenosis because repeat angioplasty or surgery is expensive, inconvenient, and potentially life threatening.
Limitations of angioplasty long-term success include abrupt closure (4.4-8.3%) and restenosis (chronic reclosure 30-50%) of the vessel—both of which are associated with excessive vascular injury.
Intravascular stenting (the placement of a supporting structure within a blood vessel) has demonstrated moderate success in addressing these issues. These devices provide structural support to keep the vessel walls from closing and minimize the problem of arterial blockage caused by plaque falling in to the vessel after inflation.
Stents have been made using materials of varied composition. U.S. Pat. No. 4,886,062 to Wiktor describes a stent made from low memory metal such as a copper alloy, titanium, or gold. Current stent designs tend to be thrombogenic (causing clot formation) and immunologically stimulating (causing cell formation). Current metal stent designs will not eliminate the restenosis problem. If restenosis should recur, follow-up treatments such as laser surgery or localized drug delivery using other angioplasty devices may be required. A stent alone can not restrict hyperplasia of smooth muscle cells, nor can it prevent restenosis or thrombus. Local delivery of antithrombogenic drugs and those capable of restricting hyperplasia of smooth muscle cells is desirable.
Drugs have been incorporated on or in a catheter or stent during the manufacturing design to provide local delivery of drugs to address restenosis, thrombus, and coagulation. U.S. Pat. No. 4,994,033 to Shockey et al.; U.S. Pat. No. 5,674,192 to Sahatjian et al. and U.S. Pat. No. 5,545,208 to Wolff et al. disclose catheters comprising absorbable/biodegradable polymers or hydrogels containing the desired dosage of a drug . Stents incorporating drug delivery may be found, for example, in U.S. Pat. No. 5,766,710 to Tumiund et al.; U.S. Pat. No. 5,769,883 to Buscemi et al.; U.S. Pat. No. 5,605,696 to Eury et al.; U.S. Pat. No. 5,500,013 to Buscemi et al.; U.S. Pat. No. 5,551,954 to Buscemi et al. and U.S. Pat. No. 5,443,458 to Eury.
When drugs or biological modifiers are applied in conjunction with the manufacture of the device, there are several problems, for example:
1. sterilization: heat or ionizing radiation alters the composition of many drugs and biological modifiers;
2. the presence of a drug imposes a shorter shelf life independent of the implantable medical device, and could require special storage (i.e. refrigeration);
3. the drug dosage is not variable for specific patient needs; and,
4. a large inventory of devices is required to provide a range of drugs and therapies.
It is an object of the present invention to provide a drug delivery system that overcomes the deficiencies associated with the application of drugs in conjunction with the manufacture of the device.
It is a further object of the present invention to provide a procedure where the drug is applied to the device at the point of use of the device.
The present invention is directed to a method of producing an implantable drug-deliverable medical device. The method comprises providing an implantable medical device, coating the device with an in vivo biocompatible and biodegradable or bioabsorbable or bioerodable liquid or gel solution containing a polymer with the solution comprising a desired dosage amount of one or more predetermined drugs. The solution is converted to a film adhering to the medical device thereby forming the implantable drug-deliverable medical device.
The present invention is also directed to a drug delivery conformal film system adapted to be applied by medical personnel at the point of use, to an implantable medical device such as cardiovascular and urology stents, pacemakers, vascular grafts, suture rings of mechanical heart valves, implantable injection or infusion ports, implantable drug delivery pumps, orthopedic hardware and appliances, and, neurological stimulating devices. The drug delivery conformal film comprises one of three in vivo biocompatible; biodegradable, bio-erodable or bio-inert embodiments: (1) cross-linked sodium alginate, (2) UV photo-active polymer, or, (3) hydrogels. A stent or other implantable medical device such as the suture ring of a mechanical artificial heart valve is coated with this biodegradable, bio-erodable or bio-inert material containing a drug, cross-linked or cured, or otherwise treated to form a film, immediately prior to placement in the body. When the film-coated device is introduced into the body, the drug contained in the film coating is released in a local region. The invention provides a point of use in vivo drug delivery system whereby the drug and its concentration can be selected by medical personnel immediately prior to implantation of the medical device.
The present invention will now be discussed in detail with reference to the preferred embodiments. Unless otherwise stated, all percentages represent weight percent.
Drugs or other biologically active materials incorporated into the drug delivery conformal film system of the present invention are intended to perform a variety of functions, including, but not limited to: anti-clotting or anti-platelet formation, and the prevention of smooth muscle cell growth on the vessel wall. Drugs anticipated for delivery include antibiotics, anticoagulants, tissue generation factor, and angiogenesis drugs. Drugs also include, but are not limited to, anti-thrombogenic drugs (heparin, PPACK, enoxaprin, aspirin, coumadin, hirudin, TPA, urokinase, and streptokinase), anti-proliferative drugs (monoclonal antibodies, heparin, angiopeptin, enxoaprin, methotrexate, cisplatin, flourouracil, Adriamycin), antimetabolites, thromboxane inhibitors, non- steroidal and steroidal anti-inflammatory drugs, Beta and Calcium channel blockers, genetic materials (including DNA and RNA fragments), and bioactive materials (such as fibronectin, laminin, elastin, collagen, and intergrins).
As stated previously, the drug delivery conformal film of the present invention comprises one of three in vivo biocompatible; biodegradable, bio-erodable or bio-inert embodiments: (1) cross-linked sodium alginate, (2) UV photo-active polymer, or, (3) hydrogels, for example, thermal irreversible hydrogels. Of these embodiments, cross-linked sodium alginate is preferred.
Sodium alginate is preferred because of its biocompatibility and in vivo biodegradability, and cross-linking film forming properties. A sterile and low endotoxin form of sodium alginate has recently become available under product number K8P569 from Monsanto, 800 N. Lindbargh Blvd. St. Louis, Mo., or under product number UP MVG from Pro Nova, Strandveien 18, N-1324 Lysaker, Norway. Very low endotoxin levels can be obtained in alginates by use of a highly specialized purification process. Alginates in a water gel form have the unique ability to form elastic films by reaction with calcium salts and/or magnesium salts. Once cross-linked, these films retain their shape and resist stress.
The preferred embodiment of the present invention is a medical release drug delivery conformal film system comprised of sterile, low endotoxin sodium alginate and sterile low-pyrogen water which uses a solution of calcium chloride to achieve gelation through cross-linking. The sodium alginates selected for this invention have a Mannuronic acid content of approximately 58 to 62% and a Guluronic acid content of approximately 42 to 38%. The alginate films thus produced have known and acceptable long-term biocompatibility and biodegradability in vivo and are manufactured in such a manner and form that renders the film sterile and biocompatible with human tissue, organs and body fluids. Sodium alginate in purified form, such as Monsanto part number K8P569 and ProNova part number UP MVG as a solution in water containing acceptably low levels of pyrogens is the preferred composition that demonstrates the desired in vivo biocompatibility and known in vivo biodegradability.
Alginates, such as sodium alginate, form aqueous solutions in either liquid or gel form. The addition of increasing amounts of non-aqueous water-miscible solvents (i.e., glycols) to an alginate solution increases the solubility of non-water-soluble compounds. As the alginate solution in this invention is intended to serve as a drug delivery film, non-water soluble drugs can be added to an alginate solution prepared with up to 10% propylene glycol, or other biocompatible solvents, substituted for water. Alternatively, water and the particular glycol may be mixed prior to the addition of the alginate. Furthermore, the drug may be added to the water/glycol mixture prior to the addition of the alginate.
Sodium alginates gel by cross-linking between a pH range of 3 to 5. Calcium chloride has been selected for its low pH and in vivo biocompatible characteristics to cross-link the algin gel creating a strong film. Alginates, when cross-linked with calcium chloride form a biodegradable/bioabsorbable film that is lubricious and thus provides a lubricating coating. This lubricious coating can assist in the insertion of the medical device into the human body.
Sodium alginate used in the embodiments of this invention may also include Monsanto Keltone HVCR. A formulation was prepared from the HVCR grade that represents the mannuronic acid and guluronic acid content that will produce suitable solutions of algin and is similar in characterizations to Monsanto part number K8P569 and ProNova part number UP MVG which is the most preferred alginate polymer of the invention. This solution has an acceptable viscosity, film forming rheology and film mechanical properties, and produces an in vivo biocompatible solution and film.
The alginate solution can be used to coat an implantable medical device, at its point of use, whereby the high viscosity alginate solution, to which a drug has been added, is rendered into a film by dipping the coated device into calcium chloride. To restrict the film to the exterior and perforations of a device, the internal diameter of the device can be blocked off, for example with a balloon, during the coating process. Over an extended period of time, through its biodegradable characteristics, the film can deliver a controlled amount of a drug that was added to the alginate solution at the point of use, in known concentration over such extended period of time. The drug may be delivered either uniformly or nonuniformly depending on the uniformity of the coating thickness.
For the following examples, non-sterile Monsanto alginate part number HVCR was used whose properties are comparable to the purified form Monsanto part number K8P569 alginate and ProNova part number UP MVG.
In order to produce a biocompatible conformal film solution, application of Good Manufacturing Procedures (GMP) and use of sterile, low endotoxin sodium alginate and sterile, low endotoxin 10% calcium chloride solutions, are recommended to ensure raw material and finished product quality.
In the preferred embodiment of this invention, sodium alginate is mixed with sterile, low-pyrogen water, which is also known as "water for injection," to form a solution. Sodium alginate concentration amounts of about 1% to about 8% by weight and of various molecular weights, in the range of 12,000 to 190,000 with a preferred molecular weight of 120,000 to 190,000 can be used to form a pourable solution tailored to rheological properties desired for the application.
Proper blending techniques are necessary to dissolve the lyophilized sodium alginate in water. A high-shear mixer, which creates vortex, is recommended. The mixing blade is placed off center in the mixing container. The mixing blade is positioned near the bottom of the solution to avoid introducing excessive air. The lyophilized alginate is slowly sifted into the vortex. The application of heat aids in dissolving the alginate powder. While blending, slowly elevate the heat to 135 degrees Fahrenheit and mix for approximately 30 minutes.
The following examples illustrate preferred compositions and formulations that can be used to prepare solutions of alginate, suitable for use in medical implant procedures.
Using the manufacturing procedures outlined above, two solutions of alginate were prepared to determine its physical film properties. The following examples were prepared:
8% Grade HVCR sodium alginate
10% Calcium Chloride Solution
92% sterile low-pyrogen water
4% Grade HVCR sodium alginate
10% Calcium Chloride Solution
96% sterile low-pyrogen water
The most preferred formula for the embodiment of this inventive device of an in vivo biodegradable conformal film system is the formula used in Example 2 that utilizes 4% sodium alginate (Part A).
Once the alginate polymer solution (in either liquid or gel form) has been prepared by the addition of the polymer to the initial liquid (e.g. water or water and propylene glycol), a drug can be added at the point of use through mixing into the solution. Alternatively, a drug may be added to the liquid to which the polymer is then added to form the solution. A device is then dipped into the solution, coating the device with the drug impregnated solution. Alternatively, the solution may be painted or sprayed onto the device. As previously stated, to restrict the film to the exterior and perforations of a device, the internal diameter of the device can be blocked off, for example with a balloon, during the coating process. The device is then place into sterile, pyrogen-free 10% calcium chloride (Part B) for up to ten minutes, cross-linking the gel and forming a strong, elastic film.
In the above experiments, the elasticity of the film created exceeded 200%. This elasticity makes the film ideal for implantable devices that are expanded once placed at the desired location (i.e., vascular stent).
The invention can be achieved using polymer systems other than alginates such as polymer systems which are in vivo biocompatible and biodegradable and cured with light, such as ultraviolet, or simply dried to form a film. For example, biodegradable PEG polymer (polyethylene glycol) or its derivatives and copolymers that are cured by exposure to ultraviolet light at the point of use may be utilized. Polymers of this nature are commercially available, for example, from Shearwater Polymers of Huntsville, Ala. and are supplied as dry powders that are water soluble and can be mixed with sterile water, or other biocompatible solvents, at the point of use. Bonding of a PEG polymer drug bearing film to a device can be enhanced by the presence of an amino group on the surface which anchors the conformal film.
The invention can also be achieved using previously-mentioned hydrogels such as thermal irreversible hydrogels that are in vivo biocompatible and biodegradable. One example is a PEO/PEG polymer (e.g. Pluronic manufactured by BASF) combined with an alginate, such as sodium alginate, mixed with water to form a solution and cross-linked by interaction with calcium ions (e.g. immersion in 10% by weight calcium chloride). Hydrogel containing films may exhibit less elasticity than the cross-linked sodium alginate films discussed above. However, such hydrogel films are well suited as coatings for devices that are static or unexpanding, such as suture rings
Although the preferred cross-linking agent is calcium chloride, other soluble- substances may be utilized. For example, calcium compounds, such as CaSO4, magnesium compounds such as MgCl or MgSO4, or barium compounds are also contemplated by the present invention for use in cross-linking.
While the invention has been described with reference to preferred embodiments it is to be understood that the invention is not limited to the particulars thereof. The present invention is intended to include modifications which would be apparent to those skilled in the art to which the subject matter pertains without deviating from the spirit and scope of the appended claims.
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|International Classification
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|European Classification
|Oct 17, 2003
Owner name: DEPUY PRODUCTS, INC., INDIANA
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text:
Fruits of Victory; The Woman's Land Army of America in the Great War
WEISS, Elaine F.
Place Published: Washington
Publisher: Potomac Books
Date Published: 2008
Description: Illus. 8vo, brown boards, d.w. Washington: Potomac Books, (2008). Very good
Comments: Presentation copy.Signed: Y
Edition: First
Jacket: Y
Binding: hardcover
Condition: fine
Language: English
Type: Books
Book ID: 252640
By This Author: WEISS, Elaine F.
By This Publisher: Potomac Books

subset: commoncrawl


text:
Crystalline sea, pristine beaches and ancient rhythms: Virginia Galateri di Genola's tips to enjoy Varigotti
The pastel colour cottages face onto a strip of sand, the last solid outpost before the fluidity of the waves. We're in Varigotti, a village that's part of the comune of Finale Ligure on the Gulf of Genoa. It has just 500 inhabitants, guardians of this wonderful place, still little-touched by the mass tourism of the Riviera di Ponente.
Virginia Galateri di Genola is our guide among the beaches and hills of the village where she spent her summers as a girl. Now a mother, she's rediscovered it as an oasis of serenity that's perfect for spending a few hours under a sun umbrella with her little Bianca Maria: "May and June are the best months to be in Varigotti, and then September and October, when there's aren't the crowds you get in August," Virginia says.
Life in Varigotti, a place with crystalline sea and golden beaches, has remained the same for many years. People still do their shopping in Sebastiano's little supermarket – "a real institution" – the smell of focaccia from Il Forno still fills the streets, and the only cinema is an outdoor one. And in the evening? "You can go for a walk in the piazzetta in the village, or simply stay on the beach." With its quiet, relaxed atmosphere, Varigotti is becoming a retreat for many famous people, like Michelle Hunziker and Eva Herzigova, who have both bought houses here.
A place by the sea and with great food, Varigotti offers – of course – sea-food and Ligurian specialities like trofie, a kind of pasta with pesto. And, as Virginia says, "there are gorgeous jam-filled sfogliatelle that I always find here and nowhere else." You can eat on the beach, in the little restaurant La Giara, or at La Caravella or Muraglia Conchiglia d'Oro, "and after dinner you can enjoy the tranquillity by the waterside or have something to drink at the Bar Lilo in the village."
Alimentari Sebastiano
Via Aurelia, 245
Tel. +39 019 698037
Ristorante Muraglia Conchiglia d'Oro
Via Aurelia 133
Tel. +39 019 698015
La Caravella
Via Aurelia, 56
Tel. +39 019 698028
Bar Lilo
Via Del Capo 39
Tel. +39 019 698085
Bagni La Giara
Via Aurelia
Hotel Albatros Varigotti
Via Aurelia, 58
Tel. +39 019 698039
To create this guide, we followed the advice of Virginia Galateri di Genola. If you have other suggestions, you can post them below in the comments box.
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Education: B.S. in Chemistry from Kerala University, India.
B.S. in Chemical Engineering from Polytechnic University, NY
M.A. in Biblical Studies from Masters Divinity College, IN.
Doctor of Biblical Studies student in Masters Divinity College, IN.
Ed.D. (Hon) from Freedom Bible College and Seminary, AK
Comment to those looking at my sermons: Hello! I always preach from my heart. If it does not excite me, I do not expect my sermons to excite others. 'Comfort Ye, My people' is the mission I have received from the Lord. I am aspiring to be obedient. You can write to me and tell me if these messages are comforting or not. I would love to hear from you.
Sermon or series that made a difference: "Developing An Apostolic Church," a ground breaking series of messages that God gave me from the book of Acts. It helped me to come out a single culture focus give up denominational leadership positions and start Gateway where ten different nationalities come together to worship and we expect many more nationalities to join.
Family: Pastor Sunny Philip is married to his wife of 29 years, Mercy Philip and together they have two adult children and one teen going to college.
Best advice given to me about preaching: "Stick to the word," by an elderly preacher. Well, that is the only thing I do in my ministry now.
Hobbies: Reading, cycling, photography, video, cooking.
What I want on my tombstone: "Nobody's hero." (Like, the hero of nobodies.)
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This is our regular stopping place for Mexican food in the area. They have a great selection at reasonable prices. They are a carry-out or dine outside at picnic tables place. Right across from the ice cream shop for dessert.
We have been driving from Ormond Beach for many years to enjoy this gem! Cute, casual walk up place with 4-5 picnic tables outside but we usually get take out. Their staff is young, energetic and are always cheerful. I know some people don't care for cilantro, but for those of us that do, it's fresh! And you can always...
We love this place ! The food is fresh and always tasty.The staff is friendly and courteous . We have tried numerous menu items and have yet to find one that is not delicious
On a work project and have been here 3 times. Order the mexican ufo with your choice of filling. I have gotten the shrimp and it is packed with shrimp in every bite! Delicious and filling!
This place was ok all the locals seemed to rave about it but we
didn't find it anything special. Once was enough for us..
Hi 190cam,
Sorry to read we were not able to give you a better experience. I wish I knew more about what it was about your trip to the Store that you didn't enjoy! We work really hard to make sure every person who visits each and every Taco Shop has an outstanding visit! Please feel free to email me...
We stopped here for our first time, I had a Chicken Burrito and my husband had a shredded Beef burrito. Our girls had a Cheese Quesadilla. We liked our burritos, they were filling and we had just enough room for dessert. Directly across the street is an amazing ice cream shop, be sure to stop in! So glad we did!
This lil hole-in-a-wall walk up counter taco shop Surprised us on how good it was.Outside seating only. Shared the 3 shredded beef soft taco special. Full of shredded beef n toppings. They were "juice running down my hands" delicious!!
Every year our family has a reunion at the beach and we start Friday night off with a walk with the dogs to this Taco Shop. I love their Mahi-mahi fish tacos with the works. My husband likes them Baja style, but they're a bit too spicy for me. He also loves their UFOs. Fast service. Only drawback is that...
Great beach, good food, great service... it doesn't get more local than this taco shack on Flagler Beach. Try the UFO if your hungry and my personal recommendation...go for the Mahi Mahi or Shrimp Baja style. Sit and eat outside in the beautiful Florida sun or walk it to the beach and have the best meal ever.
This is such a cute place to grab a quick bite. There is nothing on the menu that you could go wrong with. Close to the beach and downtown.
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Finding the perfect wedding dress can be one of the most pleasurable parts of your big day preparations and there are plenty of bridal boutiques in Mid Wales ready to help you. Set aside plenty of time to enjoy choosing your entire outfit's including accessories, wedding jewellery, wedding shoes, lingerie, tiaras and veils to team with your dream dress.
Bridal boutique and accessories supplier, Christine Anderson Design, is located in MACHYNLLETH, Powys. More info
Bridal boutique and accessories supplier, Angelika Tiaras, is located in Welshpool, Powys. More info
something totally unique for your special day-tiaras/flowers/favours/jewellery More info
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Cost of a typical dress including in-house alterations.


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Home › Forums › Shifter Karts › CR80/85 Tech Talk › Reply To: CR80/85 Tech Talk
No the fluid should not be causing that. Not if its made for tranny. I believe I have like a standard 5/10w in mine. Also don't put too much in. Sounds like the clutch spring are weak.
Update: I have got all the bugs work out of my motor! has been running good until this week when I broke a piston ring on main start.
17 years of karting
2009 NTK Yamaha heavy champion
Tag St.
80cc shifter
February 24-26, 2017
Phoenix, Arizona
Challenge of the Americas
March 3-5, 2017
New Orleans, Louisiana
SKUSA Pro Tour WinterNationals
April 7-9, 2017
Sonoma, Califorina
Challenge of the Americas


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Allendale has 11,555 residents. It is located in Ottawa county.
Pediatric Nursing schools in Allendale charged students an average tuition of $8,630.00 if they were Michigan residents, and $12,944.00 if they were non-residents, during the 2009 - 2010 school year.
The average cost of books and supplies for pediatric nursing schools in Allendale is $1,000.00. The average cost for room and board for students living on campus at pediatric nursing schools in Allendale was $7,520.00. The average cost for students living at home was $4,830.00 for the 2009 - 2010 school year. There is one pediatric nursing college in Allendale for students to choose from. Pediatric Nursing programs in Allendale reportedly graduated 230 students in the 2008 - 2009 school year.
|Average Salary
|Number Employed in City
|Registered Nurses
|Not available
|Licensed Practical and Licensed Vocational Nurses


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"On the comforter. I can that it's solid black on one side and solid red on the other? Is it truly solid red? We want black and red solid."
I purchased this for my son's college room, and it was perfect fit for the xl twin bed. He really likes it, and the other extra stuff for sure came handy....
Black/ Red 10-piece Twin XL-size Dorm Room in a Box
ITEM#: 13763686Send them off to school in confidence with this Dorm Room in a Box. This bedding set features a reversible design.
- Set includes: One (1) Reversible comforter, one (1) flat sheet, one (1) fitted sheet, pillowcase, one (1) bath towel, one (1) hand towel, one (1) wash cloth, one (1) mattress pad, one (1) pillow, and one (1)reversible pillow sham
- Style: Solid
- Comforter pattern: Solid red/black
- Comforter reverse: Solid black
- Comforter detail: Woven fabric
- Sheet weave: Plain
- Fitted sheet pocket depth: 12 inches
- Fully elasticized fitted sheet: Yes
- Sheet thread count: 200
- Materials: Cotton rich
- Care instructions: Machine washable
- Comforter: 66 inches wide x 90 inches long
- Sham: 20 inches wide x 26 inches long with a 2-inch flange
- Flat sheet: 66 inches wide x 96 inches long
- Pillowcase: 20 inches wide x 30 inches long
- Bath towel: 27 inches wide x 54 inches long
- Hand towel: 15 inches wide x 28 inches long
- Wash cloth: 12 inches wide x 12 inches long
- Pillow: 20 inches wide x 30 inches long
- Mattress pad: 39 inches wide x 80 inches long
The digital images we display have the most accurate color possible. However, due to differences in computer monitors, we cannot be responsible for variations in color between the actual product and your screen.
|Thread Count Range
|Under 200 TC
|Fabric Care
|Machine Wash
|Twin XL
|See Details
|Model Number
|Country of Origin
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Customer Reviews
Most Helpful
Great value for single beds/ kids room.
Purchased 2- sets for my boys room - aged 15 & 20, aesthetically the bed sets are fine and are a good compliment to the room in general. The comforter however is not black but more of an off black/grey and the fitted sheet, is thin and of low thread count. The sheet color and pillow cases are very rich and true to color as described via the image. I would highly recommend adding a blanket to this bedding for the winter as both the sheet and comforter are very thin. Overall a very good value for money.Read More
Not as Pictured
We were hoping to receive the black comforter with black shams etc. Instead we received a black and red patterned comforter with red shams...quality is fine and my son said to keep it but I was very disappointed that is was not as pictured.Read More
Beg in a bag
I believe there are different versions of this set. Mine came with red & black striped sheets(as pictured) and red & black(almost zebra like) stiped pillow cases but my son loved it anyway. Quality was fine - nothing to brag about. Wish it had curtains instead of the towel set.Read More
Most Recent
College bedding
Great price for the amount of product, but a little stiff on the fabric. My son had me wash it tons to soften it up.Read More
I purchased this for my son's college room, and it was perfect fit for the xl twin bed. He really likes it, and the other extra stuff for sure came handy.Read More
Overall good set.
I do think this set is attractive and a decent set for a college student. I think the colors are sharp and attractive. I noticed in some previous reviews that people were missing items. I received everything but the pillow. Not too thrilled I didn't receive everything that was advertised. But the price was great for the things I did receive.Read More
Dorm Room in a Box
It was upsetting that a couple items were missing from the box and when called in, even though they said they would send it, they didn't. It took about 3 phone calls and a couple e-mails to finally get all items to be included in my purchase. Other then that, the items were as described and my son is making great use of it in college.Read More
Good buy for college student
My son is on his way to college in a few weeks so he really hasn't used the product yet. We did open the package just to see the quility and it seems to be fine. What I can say is that the colors are great. The comforter feels thick enough. Not sure about the matress pad as we have not opened it. The towels that come with the set are a nice red color and are a little better than average thickness of terrycloth. Not thin and flimsy, but not extremely thick either. Additionally, the pillow that comes with the set is black, but more importantly it is very flat. I know that it was shoved into the box, but it hasn't "plumped up" yet and it has been out of the box for a month. So, you will need to buy a real pillow instead and use this one for a spare. All in all, from what I have seen thus far, the set seems to be a good value for any college student. The true test will be when everything is washed. If it holds up after that, then it truly is a good deal.Read More
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Thank you for your question texastech2014. The digital images we display have the most accurate color possible. However, due to differences in computer monitors, we cannot be responsible for variations in color between the actual product and your screen. Have a great day.
"What is the thread count of the sheets?"
Hello kittyk2815, The sheets thread count is 200. Thank you for shopping Overstock.com; have a great day!
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Duvet Cover Buying Guide
A duvet cover is a protective fabric cover that slips over your down comforter or duvet insert, just like how a pillowcase works with a pillow. If you have any kind of duvet insert or comforter, a duvet cover is a worthwhile investment for a number of reasons. Read on for helpful information about the benefits of having a duvet cover, including things to consider before buying one and how to use it best once you have it.
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Hotels in Oviston
Hotel reservation
South Africa
Hotel rooms in Oviston
There are not so many hotel rooms in Oviston, just 13, still everyone can find an offer to suit his choice. The most common offers in this city are guest houses, they count 10 out of 13, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the east of Oviston, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Oviston. The most populated with hotels district of Oviston is the north, 76% of cheap hotel rooms are concentrated here. Oviston is an ideal place for couple and business, such travellers rate hotels there 7.5 out of 10 on average. In Oviston one can enjoy the beauty of Gariep Dam. Moreover, there is a choice of 2 hotels, located within a walking distance from these attractions, however they might not be the cheap ones. Apart from all these, hotels in Oviston offer their customers laundry service, pets allowed, restaurant/cafe and parking. The most appreciated amenities in Oviston hotels are value and room. According to the visitors reviews, hotels in Oviston has best value for money, fantastic service and great room. Take a look at our selection of the cheap hotel rooms in Oviston to make a well-informed choice for your reservation!
Oviston cheap hotels
Guest Houses
All cheap hotels in Oviston
Best hotels in Oviston
Hotels in Oviston are spread around the city within the distance of 30.3 kilometers, while 3 hotels are located directly in the city center. The most popular accommodations in Oviston is
Abancidou Lodge
located in a 28.2 kilometers from the city center.
The best hotels are here and now. Try them!
All cities in South Africa


text: Naming Specialist 3,377pages on this wiki Add New Page Edit History Talk0 Share Naming Specialist Location(s): N/A Naming Specialist is an NPC. Description No description yet Retrieved from "http://sealonline.wikia.com/wiki/Naming_Specialist?oldid=10043" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: NPC Zaid NPC


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The magic is real in 'Illusionist'
Bittersweet and melancholy are not words usually associated with animation, but they are the ones that best fit "The Illusionist," the new feature by French director Sylvain Chomet.
As those who know and love his last film – the sprightly "The Triplets of Belleville" – understand, Chomet is a completely idiosyncratic filmmaker, someone whose eccentric animation does not resemble anyone else's.
In "The Illusionist," Chomet has teamed with another singular talent, the late French comic master Jacques Tati.
Tati wrote the script for "The Illusionist" but never directed it. His daughter Sylvia passed the script on to Chomet, who felt such a kinship with the material that he brought it to life.
"The Illusionist" is set in 1959, and the story's protagonist, who bears a considerable resemblance to Tati, is a vagabond magician of grave and serious demeanor, a mildly talented relic of an earlier time.
He travels around Europe with an obstreperous rabbit and shares the stage with up-and-coming acts like the proto-rock group Billy Boy and the Britoons.
Somehow enticed to travel to Scotland, the illusionist ends up performing in a lively pub in a tiny village at the back of the beyond. There he entrances the young waif-like girl who cleans his room, a ragged urchin who is so unsophisticated that she believes the magic is real.
When the magician leaves town for a stay in Edinburgh, the young girl stows away with him, and he ends up becoming a kind of surrogate parent. It's an interlude for both of them, something that makes the difficulties of life more bearable than they sometimes are.
Turning a live-action script into an animated one has taken some doing. Tati's features often did without dialogue, and for this film Chomet has his characters speak a strange, polyglot tongue that makes the words sound familiar but not quite comprehensible.
As with "Triplets of Belleville," much of the pleasure in "The Illusionist" lies with the story's random incidents and detours. The wacky theatrical hotel the magician stays in in Edinburgh, complete with super-short managers and acrobatic neighbors; the car-washing apparatus he gets tangled up with; even the stubborn cattle he meets on a country road, hold our attention as much as anything else.
Best of all is "The Illusionist's" gorgeous, delicately colored visual palette. Views of London's Big Ben in the rain, the Scottish countryside and especially Edinburgh as it was half a century ago – Chomet lived in the city during production – delight us and remind us how many different ways animation can charm and captivate.
There is something magical about "The Illusionist's" world, and that's as it should be.
Click here to comment on this story »


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With over 22 years practising law in California, I have had the pleasure of representing clients when they needed a helping hand and sound legal advice. As a military veteran, I have also been there protecting our military from predatory lende...
Practice areas & skills: Tax, Chapter 7 Bankruptcy, Chapter 13 Bankruptcy, Bankruptcy & Debt, Chapter 11 Bankruptcy
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Joseph Adelizzi is an attorney and principal of Security Planning Group, Inc. He has been in practice since 1984 and has litigated cases for some of the nations largest insurance companies. He is admitted to the following: California Supreme Court...
Practice areas & skills: Tax, Estate Planning, Corporate & Incorporation
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Tax attorneys understand the interplay of different tax laws and regulations, and in planning strategies to minimize people's tax liabilities. Many tax laws are written by lawyers for lawyers, and as such are very difficult to understand. There are also many different types of taxes and tax laws–for example, income taxes, corporate and business taxes, death taxes, property taxes, estate and gift taxes, sales taxes, and international taxes. Sometimes taxes are based on an inflated or incorrect value the government has placed on an entity or activity. Tax attorneys will help you challenge the value or the tax itself, and help you reduce your taxes through careful planning.


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Redlands has a population of 63,591 and is located in San Bernardino county.
For California residents, the average tuition for all Redlands cosmetology schools for the 2009 - 2010 school year was $21,796.00. For non-residents, the average tuition for Redlands cosmetology schools was $21,796.00.
The average cost of books and supplies for cosmetology schools in Redlands is $1,319.00. Students who live on campus while attending a cosmetology school in Redlands, can expect to pay an average of $10,472.00 for room and board. Students who live at home can expect average costs to be $4,113.00. Students have a choice of one cosmetology college in Redlands to attend. Cosmetology programs in Redlands reportedly graduated 20 students in the 2008 - 2009 school year.
|Average Salary
|Number Employed in City
|Not available
|Hairdressers, Hairstylists, and Cosmetologists
|Skin Care Specialists


text:
(714) 895-1992(714) 895-1992
Landmark near this address
9211 Bolsa Ave, Westminster, CA 92683
Reviews: 13
i'm not going back there anytime soon. This place is suck and they don't even know how to cut hair. Besides, the services are not that good either. Totally bad..bad..
Posted: 10/01/2008 • Link to this review


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2nd Revised edition
By (author) James G. March Herbert A. Simon
Format: Paperback
Normal Price: $57.23
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Organizations by James G. March
Book DescriptionThis new edition places the material in its contemporary context, whilst still preserving the 1958 text. It examines such concepts as bounded rationality, satisficing, inducement/contribution balances, problem solving and uncertainty absorption. The text also explores organization theory, decision making, bureaucracy, conflict, cognitive limits on rationality, planning and innovation in organizations. Herbert Simon received the Nobel Prize in 1978.
Buy Organizations book by James G. March from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780631186311
(230mm x 153mm x 19mm)
Pages: 264
Imprint: Blackwell Publishers
Publisher: John Wiley and Sons Ltd
Publish Date: 26-Apr-1993
Country of Publication: United Kingdom
Other Editions...
Books By Author James G. March
Handbook of Organizations, Hardback (March 2013)
This text charts the state of organizational research and theory during the 1960s. A compendium of results, references, concepts ideas and theories, this handbook will be of interest to both academics in organizational theory and managers facing operating problems of organizations.
Ambiguities of Experience, Hardback (April 2010)
The first component of intelligence involves effective adaptation to an environment. In order to adapt effectively, organizations require resources, capabilities at using them, knowledge about the worlds in which they exist, good fortune, and good...
On Leadership, Paperback (August 2005)» View all books by James G. March
In this series of lectures, previously unpublished in English, and here translated from a French reconstruction and interpretation by noted scholar Thierry Weil, leading organizational scholar James March uses great works of literature to explore the problems of leadership.
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Amidst the whole Kiefer Sutherland wearing a dress on Letterman because of a football bet he lost last week, our man Paul decided to email me a request. That request was to find more examples of celebrities doing the whole cross dressing thing.
Now I'm not sure what kind of kinky stuff you're into Paul but I must admit your query was somewhat innovative. I decided to put on my detective hat to find some shining examples of this kind of behavior.
I managed to find 15 pictures that might just disturb the hell out of most of you.
Examples of celebrities cross dressing after the jump
Oscar De La Hoya
Dennis Rodman
Mariah Carey
The Hoff
John Travolta
Jude Law
Brad Pitt
Salma Hayek
Gael Garcia Bernal
Hilary Swank
Katy Perry
Philip Seymour Hoffman
Dustin Hoffman


text:
Proactive Security Services
cameras, cctv, manned guarding
OUT OF HOURS SECURITY PERSONNEL Crime prevention and detection through constant site observation. Any potential site breach will be dealt with quickly and concisely. Our security personnel will be in constant contact with our controlling supervisor ensuring full support and manageability. Responsibilities: Crime prevention and detection awareness. Produce incident reports. Respond to any out of hours calls. Respond and manage the emergency alarm protocols. Possess the attitude and willingness to be part of The Organisation Management environment and culture, "Go the extra mile". Provide a professional image. Communicate effectively and professionally with the Organisation Management
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Would this be a good cold day activity?
Is this an outdoor attraction or activity?
Does this attraction require above average amounts of physical activity (long walks, climbs, stairs or hikes)?
Does this attraction have good scenic or skyline views?
Does this attraction provide visitors with a taste of the local culture?
Is this attraction exciting, unusual, or risky to visit?
Is this attraction good for couples?
Is this attraction suitable for all ages?
Is this attraction pet friendly?
Would this be a good sunny day activity?
Thanks for helping!
The harbour is tidal - sometimes the tide will be out completely and the boats are resting on the mud - at other times it is far more attractive with the boats bobing around...
read more
This could be such a nice place. The last time I was here was over 30 years ago and to be honest it hasn't changed much. They are renovating the old rail link and swing bridge, but the rest of the area is still a waste and building site. There are some nice pubs along the harbour and some clean...
So many varied attractions that cater for all ages. Great free music and food for all tastes. Wonderful views across the sea.
Nice little harbour but a lot off work being carried out. Shame theres a big hotel opposite looks dirty and drab spoils the outlook to what could be a pretty place.
Nice to walk around, but only briefly, but it needs an overhaul.
THe station area was dangerous. The harbour was nice to look at. Gives an idea of the "good old days"
The harbour is tidal - sometimes the tide will be out completely and the boats are resting on the mud - at other times it is far more attractive with the boats bobing around.
It's a working fishing harbour, go and buy your fish here, far tastier than supermarket fare. Car parking available, fountain that children can run around in,...
The area offered some lovely, friendly local pubs. We were made to feel very welcome in every pub we had been in around the harbour and town.
The harbour is very picturesque at high tide but at low tide, the water recedes and any boats there are beached. The area houses cafes, wet fish shops, whelk stalls, The Smokehouse fish and chip shop and the Rocksalt restaurant. There's lots to do and a nice place to spend half a day in the summer.
Folkestone has always had a wonderful harbour and beach area, the work on the Harbour Arm has really brought life back to the area.
As an ex local who grew up here it's great to see life back in the area.
Folkestone harbour is a big area of land that could be made better with regeneration.
There is a paved area with water fountains coming up for children and there are good gift shops and decent restaurants, but otherwise there isn't really a great deal to do there which was a bit if a diss appointment, although there is a large...
Thanks to the reopening of the Folkestone Harbour Arm ( Summer only ) the whole Harbour area is becoming a great place to be with something for everyone from pop up bars and restaurants on the arm , to the more traditional pubs around the Harbour area; pour on some great weather and recipe for a good day out.
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text:
These times they are a changing!!!
This time last year I was running 5K in 31.20 PB and managing 10's in 1:06.30 then it all seemed to go to pot. I had a bout of sciatica but not too bad, then another leg injury which laid me off running for 4 weeks. Since then all I've managed to do is 5K's in about 36-38 minutes. Most of the running has been forest tracks which is always slower. So this morning I decided to do a 5K all tar/pavement run and see if I could speed up a bit. I did manage but can't say it was easy as it wasn't. Just don't know why I'm so much slower, will have to get stuck into some HIIT again perhaps, or recharge my batteries.
Garmin stats - connect.garmin.com/activity...
Does anyone else find drivers are not very considerate to runners in a morning, I had terrible trouble crossing two roads, will have to adjust this route I think.


text:
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It's a long haul to your honey hole... especially when you're lugging a 30-lb. auger, too. Better get this handy carrier to do the heavy lifting! The Stinger Ice Auger Locker attaches quickly and easily to your ATV's front rack without tools, providing secure transport for your heavy power auger. Rubber-coated pads prevent scratching or damage. Installs perpendicular to ATV wheels, or straight ahead when the trails or portages are narrow.
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text:
Originally written on Fox Sports | Last updated 9/1/14
The Auto Club 400 proved to be the most exciting NASCAR Sprint Cup race at the track in recent history and arguably was one of the season's best. The new cars used every inch of track throughout the race, and at the end, the two drivers who feuded the previous week battled one another once again for the victory. Kyle Busch looked like he had the strongest car most of the afternoon and led 125 of the 200 laps. Joey Logano came on strong toward the end and took over the lead, but Denny Hamlin reeled him in and the two collided racing into the final turn. The resulting carnage enabled Busch to scoot through and claim victory, which he deserved given him strength. Afterward there were plenty of insults being tossed between drivers, but Hamlin left in an ambulance after his hard hit. Tony Stewart couldn't resist getting in on the action, and confronted Logano for blocking on a late restart. It was an action-packed afternoon that could use a week off to calm down some tempers before hea...
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Horse Breeds of North America
By (author) Judith Dutson
Format: Paperback
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Horse Breeds of North America by Judith Dutson
Book DescriptionHorses of all breeds, colours, shapes, and sizes are perennially fascinating to equine enthusiasts of all ages. Collected in a perfect little pocket guide no horse lover will be able to resist, here are images of 96 breeds that call North America home - galloping, playing, grazing, working, or simply striking a pose. For each breed readers will find a full-page photograph accompanied by at-a-glance conformation and historical facts. A small map shows where the breed originated, and additional information includes the horse's special qualities and its most common uses. Home grown favourites such as the Morgan, Appaloosa, and the less- well-known Nakota and Florida Cracker horses are featured along with imported breeds that have influenced native equine bloodlines, such as the Thoroughbred, Arabian, and Percheron. From the very large (the mighty Shire) to the very small (the tiny Miniature), and everything in between, never has such a range of horse fact and photography been packed into such an appealingly small gift book. This 96-breed survey covers North America's remarkable diversity of horse breeds, from the popular and well- known to the rare and obscure.
Buy Horse Breeds of North America book by Judith Dutson from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9781580176507
(115mm x 152mm x 15mm)
Pages: 208
Imprint: Storey Books
Publisher: Storey Books
Publish Date: 6-Oct-2006
Country of Publication: United States
Books By Author Judith Dutson
96 Horse Breeds of North America, Paperback (October 2005)» View all books by Judith Dutson
Covers the special horses of North America. This is a comprehensive guide, featuring in-depth profiles and photographs, to 96 breeds that call North America home. Covering colour breeds, light horses, heavy horses, ponies, donkeys, and mules, the author offers insight into the purpose each was bred for, and where it is found in North America.
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text:
High power in spectacles
Current spectacles power is -8 and for the last 10-12 years has kept worsening. Is surgery a good option and what kind of surgery would you suggest?
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Doctor Answers (3) on High power in spectacles
Dr. Arjun Kumar Singh
38 yrs. of exp | Patna | Ophthalmologist/ Eye Surgeon
INR 200 for 24 hrsCHAT NOW
Refractive surgery can only be advised after pachymetry and retinal examination for -8 D. At the age of 30 years going for refractive surgery is not a wise decision because around 40 years everybody needs glass for reading and u will be reading without glass throughout your life if u don't undergo refractive surgery at present . these days due to side effect of hair dye most of the people are having early cataract. You will be having zero power after cataract surgery if u desire at that time. At present if you go fr refractive. Surgery , you will be without glass only for 10 years . After refractive surgery , cataract surgery is difficult. Now you can take your decision yourself.
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Dr. Vaibhev Mittal
8 yrs. of exp | Sangrur | Ophthalmologist/ Eye Surgeon
INR 150 for 24 hrsCHAT NOW
hello lasik is very good option to get rid of glasses Doctor will perform few tests (Schirmer test, Pentacam and Fundus examination) and if all tests are normal then you can go for lasik surgery without fear. Success rate of LASIK is over 96%.
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Dr. Shahnawaz Kazi
11 yrs. of exp | Mumbai | Ophthalmologist/ Eye Surgeon
The never sytems can treat higher numbers with laser also. if corneal thickness is good then advanced surface ablation can be done.or else phakic IOL is also a good option.
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text:
The internet can be a useful source of information, although not all websites are reliable. The websites listed below are good sources of reliable information. However, Cancer Council is not responsible for their content.
Government websites
- Cancer Australia
- Cancer Institute NSW
- Commonwealth Department of Health and Ageing
- NSW Health
- Childrens Cancer website
Aboriginal health websites
- Cancer Council Aboriginal Cancer website
- Australian Indigenous Health InfoNet
- Cancer Australia Indigenous resources
- National Indigenous Cancer Network
- Menzies School of Health Research
New South Wales resources
National websites
- Australian Cancer Survivorship Centre
- The Peter MacCallum Cancer Centre
- Clinical Oncological Society of Australia
- Cancer Council Australia
- National Breast Cancer Centre
- Ovarian Cancer Australia
Databases and directories
Depression and suicide prevention resources
International websites
- American Cancer Society
- Befrienders Worldwide
- Cancer Research UK
- CancerCare
- International Agency for Research on Cancer (IARC)
- Memorial Sloan Kettering Hospital
- National Comprehensive Cancer Network (NCCN)
- Cancer Help (UK)
- International Union Against Cancer (UICC)
- Macmillan Cancer Support
- National Cancer Institute (US)
- US National Cancer Institute


text:
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Fare AOC Mini Umbrella: Push button opening, 3 section frame and tightly packed as your individual rain protection."
From £10.95, Min Qty 25.
Stop lugging the huge golf umbrella around with you in fear of the British weather and take our branded FARE Knighton Foldable Golf Umbrella to brave the showers instead.
Comes with an automatic open/close golf mechanism. Large enough for two people with high-quality windproof system so it can withstand storms. Two-coloured soft touch handle with raised push button.
Prices as standard for a 1 colour print to 1 panel. Multiple branding positions and colours are available - POA.
Why choose personalised umbrellas? Custom printed umbrellas. All of our personalised umbrellas can be branded with your design, with your logo printed on as many panels as you wish. We have a wide range of standard panel colours and can even pantone match the canopy colour if required. You will find children's, boxed, telescopic and golf umbrellas amongst our range.


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Starter For Ten Gallery
Starter for Ten is a romantic comedy set in the mid-eighties about a working-class kid (James McAvoy) as he navigates through his turbulent first year at University. It's great fun and we have some pictures from the film to enjoy…
Roll your mouse over the left and right-hand sides of the image and then click to view more pictures.
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Read our review of Starter For Ten or our interview with James McAvoy or buy it
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