text:
The appeal of organic products may have survived the U.S. recession -- the category eked out modest sales growth in 2009, and mainstream retailers such as Wal-Mart
A recent study conducted by the Natural Marketing Institute, which polled more than 50,000 consumers in 20 countries, found that while roughly two-thirds of consumers are concerned about the environment, their purchasing decisions are motivated primarily by price. That finding is supported by a similar (but unrelated) survey, which revealed that the percentage of U.S. consumers who plan to increase their green-product spending has declined from 2009. Furthermore, within developed economies such as the U.S., U.K., France, and Germany, surveyed consumers cited higher prices as a key barrier to green purchases.
What all this means is that companies will have to maintain a laserlike focus on price, which may eventually come at the expense of margins. Whole Foods Market
Meanwhile, Clorox
Don't get me wrong, I'm not all doom and gloom on the profit outlook for organic and better-for-you products. Not long ago, I suggested that organics specialist Hain Celestial Group
Moreover, a retailing titan such as Wal-Mart likely will be able to pressure its vendors (i.e., manufacturers) to give ground on pricing, enabling Wal-Mart itself to preserve margins. As for organic and natural products that Wal-Mart sells under its Great Value brand, well, that might be a different story.
Ultimately, while the organic products market probably still has plenty of runway ahead, as an investor, I'd make sure that there's nothing synthetic about your sense of caution, nor your attention to company-specific developments.


text:
Reviewed By Robert S (SAINT LOUIS, MO) Reviewed for a 2008 Toyota Corolla —11/20/2016 5:13 PM
THE directions are a bit vague. But the plugs only fit one way so its pretty simple.
Reviewed By Brian D (Marietta, GA) Reviewed for a 2010 Toyota Corolla —11/5/2016 6:41 AM
Been wanting one for a while and decided to take the plunge when I saw it discounted. So worth it! It's heavy duty and easy to install. Comes with the anti wobble screw pin which was unexpectedly awesome. One star off for appearance cause it came in which some chip to the paint. But I just used a clear sealant to prevent possible further chipping/rust. Have only used it for a bike hitch so I cannot say for towing, but it looks like it can handle it very well.
Reviewed By Glen H (Leesburg, FL) Reviewed for a 2015 Toyota Corolla —5/4/2016 4:31 AM
Draw Tite has kept up their reputation of superior quality with this unit. Complete with all hardware, this has to be the EASIEST install ever! The welded hitch nuts were already in place from the factory. It was a simple matter of putting the receiver in place and installing 4 bolts with washers on them, torquing them down and driving away. 15 minutes including getting and putting away the wrench! The only negative was packing. My unit has a dime size chip in the powder coat. Esthetics only.
| Toyota Corolla Base Trailer Hitches
Toyota Corolla LE Trailer Hitches
| Toyota Corolla S Trailer Hitches
Toyota Corolla XLE Trailer Hitches
| Toyota Corolla XRS Trailer Hitches
Toyota Corolla CE Trailer Hitches

subset: commoncrawl


text:
KIMT News 3 – Below is a compilation of responses to Wednesday's shooting death of two Des Moines area police officers from those in the political spotlight:
"My heart goes out to the officers who were fatally shot, their families, and their fellow officers. This cowardly and senseless act of violence does not represent who we are as Iowans or Americans, and I am proud of our communities coming together to support our first responders. To have such a tragedy occur in our own backyard is a stark reminder of the sacrifices police officers, all first responders, and their families make to keep us safe. They are all in my thoughts and prayers every day." — U.S. Senate candidate Patty Judge
"My heart goes out to the families of the two police officers who were so tragically killed serving their communities in the line of duty. These acts are truly unconscionable. The brave men and women who serve and protect us need our full support and I urge anyone with information on these devastating events to please contact your local police department." — Monica Vernon, U.S. House of Representatives candidate for Iowa's first district
"Our hearts and prayers are with the families of our two Des Moines metro police officers who were tragically murdered early this morning. This is a sickening tragedy experienced by our state and Nation today, and this is a very important time for us to stand together in support of our men and women in Blue. Please join me in continued prayer for the affected families and for all of our law enforcement officers. They have lost two of their own and we have lost two of our heroes." — Iowa Rep. Steve King
"There are no words to adequately express my sorrow and heartache over the senseless murders of two police officers in the line of duty. I offer my deepest condolences to these officers' families, their law enforcement colleagues, and loved ones.
As Iowans, we are thankful for these two law enforcement heroes who tragically lost their lives. We are grateful for all the men and women in uniform who selflessly risk everything to protect us and keep our communities safe.
I hope law enforcement officers across our state, who are feeling a profoundly numbing loss, can take at least some solace and comfort from the gratitude and support they have from Iowans." — Iowa Attorney General Tom Miller


text:
Madrigalle W01 Nocturne Fonts
<link href="//db.onlinewebfonts.com/c/eee329c79492d61afc4ebfc925e4ae87?family=MadrigalleW01-Nocturne" rel="stylesheet" type="text/css"/>#2 Using @import CSS directive, put the following line in add to your css file.(http | https)
@import url(//db.onlinewebfonts.com/c/eee329c79492d61afc4ebfc925e4ae87?family=MadrigalleW01-Nocturne);#3 Use font-face declaration Fonts.(http | https)
@font-face {font-family: "MadrigalleW01-Nocturne"; src: url("//db.onlinewebfonts.com/t/eee329c79492d61afc4ebfc925e4ae87.eot"); src: url("//db.onlinewebfonts.com/t/eee329c79492d61afc4ebfc925e4ae87.eot?#iefix") format("embedded-opentype"), url("//db.onlinewebfonts.com/t/eee329c79492d61afc4ebfc925e4ae87.woff2") format("woff2"), url("//db.onlinewebfonts.com/t/eee329c79492d61afc4ebfc925e4ae87.woff") format("woff"), url("//db.onlinewebfonts.com/t/eee329c79492d61afc4ebfc925e4ae87.ttf") format("truetype"), url("//db.onlinewebfonts.com/t/eee329c79492d61afc4ebfc925e4ae87.svg#MadrigalleW01-Nocturne") format("svg"); }
1.0; 2002; initial releaseAuthor
Dieter Steffmann, KreuztalCopyright
Copyright (c) Typographer Mediengestaltung, 2002. All rights reserved. Digitized by Dieter Steffmann, Kreuztal.Description
Kinder-Vignetten. Copyright (c) Typographer Mediengestaltung, 2002. All rights reserved. Digitized by Dieter Steffmann, Kreuztal.License
Have fun and enjoy
4Point Deco W95 Regular
4Point Deco Trademark of Deniart Systems.Copyright
4Point Deco Deniart Systems. 2011. All Rights ReservedDescription
This font was created using FontCreator 6.2 from High-Logic.com
Dollar Bill V2
Dollar BillStyle
Twicolabs TypefoundryAuthor
Twicolabs TypefoundryTrademark
Dollar Bill is a trademark of Twicolabs Typefoundry.Copyright
Copyright (c) 2013 by Twicolabs Typefoundry. All rights reserved.Description
Copyright (c) 2013 by Twicolabs Typefoundry. All rights reserved.
Jillican Bold
Style : BoldPackages
2.01 2003Company
Ray LarabieTrademark
Jillican is a trademark of the Typodermic foundry.Copyright
Copyright (c) Typodermic, 2001. All rights reserved. Do not distribute. Report piracy to firstname.lastname@example.com
Copyright (c) Typodermic, 2001. All rights reserved. Do not distribute. Report piracy to firstname.lastname@example.com
ITC Regallia W01 Regular
Phill GrimshawTrademark
ITC is a trademark of International Typeface Corporation Registered in U.S. Patent and Trademark Office and may be registered in certain other jurisdictions;Regallia is a trademark of International Typeface Corporation and may be registeredCopyright
Copyright 1998 International Typeface Corporation. All rights reserved.Description
Please review the description of this font at http://www.itcfonts.com.
1.00 June 14, 2008, initial releaseCompany
Megami StudiosAuthor
Rob BarbaCopyright
Typeface Megami Studios. 2008. All Rights ReservedDescription
This font was created using FontCreator 5.6 from High-Logic.comLicense
Megami Studios Fonts License Agreement(Free Fonts)All fonts Megami Studios. All Rights Reserved. No Megami Studios Fonts (fonts) may be altered or redisributed without the express permission of Megami Studios. These fonts are meant as freeware for self-publishing and non-profit use only. This does not include usage by major publishers (e.g. Marvel, DC, Dark Horse, Oni, Image, SLG, Top Cow, Crossgen, Tokyopop, Del Rey, Viz Media, and their subsidiaries) or major websites (e.g. Penny Arcade, PVP, Megatokyo) (collectively, major publishers) without a license fee. Use by a major publisher (or an employee) and use for mainstream publishing will incur a license fee to be paid to Megami Studios. In short:*Anyone may use these fonts for non-profit projects.*If you are a self-publisher and/or creator, you may use these fonts for any independent published project, for profit or non-profit.*If you are an independent creator publishing through a major publisher (see above for some examples), there is a license fee.*If you are not an independent creator and you plan to use these fonts in a commercial project, there is a license fee.Please email Megami Studios for fees on free font usage, as well as an invoice for your records.
VegaAntikva W00 BoldItalic
Linotype GmbHTrademark
Vega is a trademark of Franco Luin.Copyright
Copyright (c) 1994, 2001, 2003, 2004 Linotype Library GmbH, www.linotype.com. All rights reserved. This software may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype Library GmbH.Vega is a trademark of Franco Luin. This typeface is original artwork of Franco Luin. The design may be protected in certain jurisdictions.License
NOTIFICATION OF LICENSE AGREEMENTYou have obtained this font software either directly from Linotype GmbH or together with software distributed by one of Linotype's licensees.This font software is a valuable asset of Linotype GmbH. Unless you have entered into a specific license agreement granting you additional rights, your use of this font software is limited to your workstation for your own use. You may not copy or distribute this font software. If you have any questions regarding your license terms, please review the license agreement you received with the software.General license terms and usage rights can be viewed at www.linotype.com/license.Generelle Lizenzbedingungen und Nutzungsrechte finden Sie unter www.linotype.com/license.Pour plus d'informations concernant le contrat d'utilisation du logiciel de polices, veuillez consulter notre site web www.linotype.com/license.Linotype GmbH can be contacted at:Tel.: +49(0)6172 484-418
Times New Roman W01 Bold It
Times New RomanStyle
The Monotype CorporationAuthor
Monotype Type Drawing Office - Stanley Morison, Victor Lardent 1932Trademark
Times New Roman is a trademark of The Monotype Corporation.Copyright
2014 The Monotype Corporation. All Rights Reserved. Hebrew OpenType Layout logic copyright 2003 & 2007, Ralph Hancock & John Hudson. This layout logic for Biblical Hebrew is open source software under the MIT License; see embedded license description for details.License
This font software is the property of Monotype Imaging Inc., one of its affiliated entities, or its licensors (collectively, Monotype) and its use by you is covered under the terms of a license agreement. You have obtained this font software either directly from Monotype or together with software distributed by one of the licensees of Monotype. This software is a valuable asset of Monotype. Unless you have entered into a specific license agreement granting you additional rights, your use of this software is limited by the terms of the actual license agreement you have entered into with Monotype. You may not copy or distribute this software. If you have any questions concerning your rights you should review the license agreement you received with the software. You can learn more about Monotype here: www.monotype.com
Gesta SemiCondensed W01 Lt It
Rui Abreu, PortugalAuthor
Rui AbreuTrademark
Gesta SemiCondensed Light Italic is a trademark of Rui Abreu, Portugal.Copyright
Copyright (c) 2012 by Rui Abreu, Portugal. All rights reserved.Description
Current license info at www.r-typography.com/RA_EULA.html


text:
Winning Forex High Quality Signals Features That Will Grow YOUR Account!
Quality Over Quantity of Signals. Disciplined Approach
Clear Entry, Exit and Take Profit, Stop Loss Level
Monitoring and Member Notification Till Trade Signals Close
NO Mari-triangle and No Averaging
Backed by Research and Analysis of Professional Traders
SignalsTrader Trade Copier* - No more missing signals (VPS Required for Best Results)
How Forex Signals are Beneficial for Traders?
Obviously to have 24 hour a day monitoring of the Forex Market is a great benefit. But there are other benefits as well, for example: A trader may have been experiencing a difficult week in the market, he sees a Buy opportunity but he is hesitant to pull the trigger. If the trader received an alert to buy on the same currency it may give him the confidence to proceed. Another side benefit is trade strategy. When you have confidence in the trade alerts you are receiving, you can focus more on your trading strategy than looking for trade opportunities. Every Forex signal sent to subscribers is considered for risk reward ratio, probable pip move and other factors. Many traders new to the Forex market find a whole new world of strategy by just following along with the signals.
Forex Signals Email Alerts
Our technical department updates you with email alerts frequently. This is to ensure of entry every trade. At the time of running a trade by our Forex signal sometime we need to adjust trade by modifying take profit, stop loss, trailing stop or need to close early. We instantly circulate this update through email to all members. We also notify by email after reaching TPs or SL. All Signal modifications are important to manage a running trade more effectively, Hence, You can set new email alert for our intraday profitable forex signals in your cell phone that you will easily be notified each and every email from us.
Reasons why Forex Traders & Investors Trust our FX Signals
- Consistently Profitable Signals - Our Forex Signals are timed and delivered in a manner that ensures a low rate of failure over-time.
- SmartRisk System for Trade Management - Our SmartRisk System ensures that if a trade starts to go negative, there is Stop Loss in place to minimise the risks. Trader's will not have to worry about their accounts being blown over night.
- Proven History - Our performance history speaks for itself.
Hurry Up and Subscribe To SignalsTrader.com Trading Signals!!
Check out our affordable Pricing Here!
Why SignalsTrader Signals?
Simply, because it is profitable for you as well as for us! Signalstrader.com, is a signal provider in global currency market. We are different and some more special than others because we have a large "Forex market" analytical expert team who make an effective analytical report. On the basis of analytical report signal is made. Have a monitoring team to observe the market and accuracy the given signal. As their observation report Forex pips signal is 95% accurate. Our highest interest is that Traders want to win as their optimum target. We will help you to control "Take Profit " and " Stop loss ". We are constantly monitoring the market, no matter your location in the world. If you try to deposit at any bank you get an annual income of a maximum of 12% and at the same time, you would not be able to touch to your deposits. It means if you deposit at the Bank within 1 year, $10,000, 1 year you will get $1200 profit. If we write this process in Forex terms, you deposit $10,000 in Forex and trade with 10% of the deposit and If you earn minimum 650pips within 1 month Also for convenience, we will provide live support you.


text:
- Mattel Indonesia PT
- 0 reviews
- 12 gaji
Job Description:
- Develop and analyze soft goods pattern
- Labor and yield to meet aesthetic and cost requirements
- Adaptable to manufacturing system and assure the achievement schedule
Job Requirement
- Education background: Diploma or Bachelor Degree in Textile/Garment
- Working experience in the same position for min 2 years in Textile
- Must have good knowledge on pattern making (turn sketch to 3D model)and posses good sewing skills
- Dynamic personality, proactive, analytical thinking and open minded with' a can do'attitude
- Strong communication and negotiation skills
- Work under pressure and diverse condition
- Team oriented with good personal skills
- Fluent in English-both written and oral
- Based in Cikarang – Bekasi
If you meet the requirement, please send your complete CV (attachment only in Word Format) & photograph to APPLY NOW (attachment is not more than 500KB)
Please put code "Pattern Engineer" on your subject email.
Only short listed candidate will be proceed.
Deskripsi Perusahaan
PT Mattel Indonesia is a worldwide company and a leader in toy business. We operate as the largest manufacturer of dolls and we employ about 5000 people in Indonesia. We produce Barbie, fashion dolls. It has two plants at Jababeka Industrial Estate Cikarang, Bekasi West Java
Currently we have several positions in our company requiring people with fresh ideas and insight to grow professionally with us. Our working environment offers opportunities for people to grow and develop, enabling you to thrive and achieve your maximum potential
We invite you to join our team as


text:
Vintage Military Blanket Pillows – Gray w/Red Stripe
Product: Vintage Military Blanket Pillows – Gray w/Red Stripe
Retailer: Red Barn Mercantile
Skout puts vintage military blankets to fabulous use with these super cool 19-inch pillows. Every product in the Skout collection has a reduce, reuse, recycle element. Due to the nature of using reclaimed, recycled or vintage fabrics, variation will occur. The design and quality will always be consistent making each piece individual. Also available in a larger 24-inch size.


text:
Teaching Moves Beyond the Classroom Somewhat surprisingly, and despite huge advances in technology and communications, very little has changed in the way we teach – either in formal educational settings or in the world of work. Whereas the ways we learn and access knowledge in our day-to-day lives are almost entirely informal, the vast majority of teaching is still done ...Read More »
Creativity versus Literacy
I came across this video of Sir Ken Robinson speaking about how schools kill creativity. He contends that more emphasis should be placed on teaching creativity in schools, and that teaching creativity should be as important as teaching literacy. Here are some of his other key thoughts and insights: The great thing about children is that if they don't know, ...Read More »
Twitter in the Classroom
During Clayton Christensen's talk at the World Innovation Forum about innovation in education and healthcare, Dr. Christensen made a point about how technology will move more of education out of the classroom and onto the Internet. He was mostly speaking about augmenting home schooling, but also about school leavers earning their equivalency online, and online advanced placement courses for kids ...Read More »
David Merrill Demonstrates Siftables – The Toy Blocks That Think
Here is an interesting video of MIT grad student David Merrill demonstrating Siftables — cookie-sized, computerized tiles you can stack and shuffle in your hands. These future-toys can do math, play music, and talk to their friends, too. Does this technology have any promise as an alternative human-computer interface? Check it out: What do you think? @innovateRead More »


text:
Hotel The Peninsula Tokyo
Locatie en stad
|Check-in vanaf
|Check-out tot
- Eigen parkeerplaats
- Aangegeven parkeerplaatsen voor gehandicapten
- Audio-visuele conferentie-accomodatie
- Executive floor / business etage
- Kluizen bij de receptie
- Ramen te openen
- Noodinformatie
- Overzicht vluchtwegen
Services in het hotel
- Express Checkout
- Kosteloos dagblad
- Business Center
- Wasservice
- Babysitter
Stijl en sfeer van het hotel
The Peninsula Tokyo is ideally located in the prestigious business district of Yurakucho, opposite the Imperial Palace and Hibiya Park. With its main entrance at the intersection of Hibiya-dori and Harumi-dori Avenues and directly adjacent to the Hibiya subway station, the Peninsula Tokyo is close to the Marunouchi and Otemachi financial districts, the theatre district and Hibiya Park. Also conveniently nearby is the shopping capital of Ginza. The railway station for the airport express and bullet trains is also located nearby the hotel. Facilities include four restaurants, several with private dining rooms, fitness center and the Peninsula spa by ESPA, nine meeting rooms, full range of business services, accessible guestrooms and facilities, indoor heated pool and onsite valet parking. Services include 24-hour room service and concierge. The Peninsula Tokyo offers 267 guestrooms and 47 suites, some of the most spacious in Tokyo. Most rooms have views of the Imperial Palace or Hibiya Park. All rooms and suites feature the latest luxurious amenities, including marble bathrooms with separate bath and shower, double wash basins, allergy-free and soundproofed rooms, 42-inch plasma cable television, minibar, black-out drapes, bedside controls, work desk with dataport, fax machine and printer, complimentary cabled and wireless high-speed Internet service, 2-line cordless speaker telephones that work city-wide, DVD/Video/CD players, stereo, iron and ironing board, daily newspaper and in-room safe. The property is located 0mi N of TYO-Tokyo -The property is located 50mi W of NRT-Narita International Airport -The property is located 13mi N of HND-Haneda Airport
Aantal etages 24, Meetinghotel / congreshotel
0:00 tot 0:00
Receptie in het weekend:
0:00 tot 0:00
Check-in vanaf:
Check-out tot:
Geaccepteerde betaalmiddelen
- Diners Club
- Visa
- Eurocard / Mastercard
- American Express
- Japan Credit Bureau (JCB Int'l)
Uramachi 1-8-1, 100-0006 Tokyo - Chiyoda
The property is located 0mi N of TYO-Tokyo -The property is located 50mi W of NRT-Narita International Airport -The property is located 13mi N of HND-Haneda Airport, TYO-Tokyo, YOK-Yokomaha, QCB-Chiba, Saitama, Tokorozawa, NRT-Narita International Airport, HND-Haneda Airport, Ginza Shopping District, Marunouchi Dori Shopping District, Imperial Palace, Kabuki Theatre, Theatre District, Big Sight Convention Center, Tokyo International Forum, Hibiya Park, Asakusa, Akihabara Electronics District, Tsukiji Fish Market, Roppongi, Barclays Bank, Boeing, Goldman Sachs, HSBC, JP Morgan, Lehman Brothers, Marubeni, Merrill Lynch, Mitsubishi, Mitsui and Company, Nomura Securities, Sumitomo Bank, Toyota Tokyo, UBS, United International Pictures, Recreational Facilities
- 1,63 km
- 13,74 km


text:
Blending classic craft techniques with contemporary designs, this pure katan silk saree which has been intricately hand-woven using zari weave process by Banaras handlooms tells its distinct textile story. Soft Sorbet colour with pure and tested golden zari motifs, gives ethereal feel.
Accompanied by a blouse piece of similar grace(As shown in the last pic)
525 g
Shipping Charges
Not applicable
Shipping Time
Care Instructions
Dry clean only
This is a handcrafted product, due to which slight variation in colors or design may occur. Slight irregularities are distinctive and will add to the beauty of this unique creation
Return Policy
Returns accepted within 7 days of delivery


text:
Bromine in Ahmedabad
Found: 3 products← Back to category "Pure chemical elements"
Acetyl Bromide
PRODUCT SPECIFICATION Product : Acetyl Bromide Synonyms & Read more
India, Ahmedabad
Zinc Bromide
We are way forward in formulating and trading a wide range of Zinc Bromide across the world. These products are formulated under the guidance of our skilledchemical experts. Zinc Bromide is a white powdery salt. The special feature of this chemical is free from alkalinity. This is widely used in the Read more
Liquid Bromine
With wide and rich industrial experience, we are able to offer Liquid Bromine 99.5 percentage Min: Br2 Cas No. : 39416-48-3 across the world. These products are formulated under the guidance of the chemical experts. This Dark reddish bromine liquid is used in chemical industries for various alkalizi Read more
Similar goods in India
Multivite Gold Calcium Medicines
MEDISELLERS, THE LEADING EXPORTER OF PHARMACEUTICAL PRODUCTS AND MEDICINES ACROSS THE WORLD. WE PROVIDE THE BEST QUALITY MEDICINES AND QUICK SERVICES FOR ALL CUSTOMERS AROUND THE GLOBE WITH ALL NECESSARY TRACKING INFORMATION OF THE PRODUCTS. WE DEAL IN ALL MAJOR BRANDS LIKE NATCO , CIPLA Read more
Prime Test
Delivery to Ahmedabad fromDelhi
Display phones
Cashew Nut Shell Liquid-(CNSL)
CASHEW NUT SHELL LIQUID (CNSL) is a versatile raw material for the production of number of commercially important products specially for Surface Coatings because of its special composition. Considerable amount of work has been done with great success in various Research Laboratories and Industries b Read more
Delivery to Ahmedabad fromHyderabad M.Corp
All 2
We are engaged in offering our clients with a comprehensive range of Silicon Softeners. These are processed in line with international quality standards. Our range is widely acclaimed for its accurate composition and longer shelf life. Specifications of our range are given below: ZYSIL 1010 - Sil Read more
Delivery to Ahmedabad fromKolkata
Imported Brand Chemicals
Tresure Of Imported Brand Chemicals From Ready Stock Adrenaline Bitartrate 27053 B.D.H. 5 gm Alcian Blue 8gx B.D.H. 25 gm Azomethine-H Monosodium Salt Hydrate 30022392 FLUKA 100 gm 1-Butane Sulphonic Acid Sodium Salt Read more
Delivery to Ahmedabad fromMumbai
Ultra Clean E
Ultra Clean E, is a heavy duty industrial cleaner which cleans heavy oil, dirt, grease and buty sweat from ornaments and glasses it. It is neutral cleaner compounded by polygenic glycol ether, fat dissolving amines, chelating agents and metal inhibitors. At the time of operation PH of the both retai Read more
Delivery to Ahmedabad fromNew Delhi
All 2
Linear Alkyl Benzene Sulphonic Acid
We offer linear alkyl benzene sulphonic acid which is widely used in formulation of complete range of synthetic detergent powders, liquids & cakes. The highly active matter, quick miscibility with water & low salt content, allows our range to be used in a variety of formulations. Applicatio Read more
Delivery to Ahmedabad fromChennai
All 2
Dolomite Lime
Our company is engaged in offering a wide range of superior quality Dolomite Lime, which is a highly reactive product. These are considered as an essential compound for various industrial processes. Hence we adhere to stick to strict quality parameters to satisfy varied customer requirements. Our ex Read more
Delivery to Ahmedabad fromNew Delhi
All 2
Supreme Pgr
Supreme PGR fertilizer is used as a foliar spray for stimulating the growth of Cotton, Tea, Coffee, Cereal, Pulses, Oil, Fruit, Flower,Cardamoms & all vegetable crops. It is also used to check the fruit flower drop and help in increasing the vigour of the flush with long sustenance for output of Read more
Delivery to Ahmedabad fromKolkata
Cross Carmolose Sodium
Our organization offers a comprehensive range of Cross Carmolose Sodium. This is an internally cross-linked sodium carboxymethylcellulose, which is used as a disintegrate in pharmaceutical formulations. These are formulated, first by soaking crude cellulose in sodium hydroxide. Later, these are reac Read more
Delivery to Ahmedabad fromMumbai
Sodium Citrate - Indian / Imported
Sodium citrate is the sodium salt of citric acid with the chemical formula of Na3C6H5O7. Sodium citrate possesses a saline, mildly tart, flavor. For this reason, citrates of certain Alkaline and Alkaline Earth metals (e.g. sodium and calcium citrates) are commonly known as sour salt (occasionally ci Read more
Delivery to Ahmedabad fromDelhi
All 2
Caustic Soda Lye, Flakes / Prills
We are engaged in providing our clients wide assortment of Caustic Soda Lye, Flakes / Prills that is extensively used in various industries. These are procured from trustworthy vendors who accurately compose these using finest ingredients. Besides, these are available in various specifications and o Read more
Delivery to Ahmedabad fromShahade
Iso Amyl Acetate
Commonly used to impart the flavor of bananas in food items, Iso Amyl Acetate is an ester of acetic acid and isoamyl alcohol. It is also known for its intense odour of bananas and pears, due to which it finds application in testing the efficiency of gas masks. Relevant chemical properties of this p Read more
Delivery to Ahmedabad fromVadodara
All 2
Whiting Agent - Brightning Agent
Formulating a wide range of whiting agent, we have been able to meet the varied requirements of textile industry which is a low forming surface active agent. Being a powerful wetting and re wetting agent, it finds varied use in textile processing operation such as dyeing, bleaching, etc. Read more
Delivery to Ahmedabad fromMumbai
All 2
Chemical Enzymes
Based in Pasadena, California, BioCatalytics is a leading provider of technology and services for the application of chemical enzymes. BioCatalytics offers an exceptionally broad product line of enzymes catalyzing a number of synthetically useful chemical reactions, including lipases and esterases f Read more
Delivery to Ahmedabad fromMumbai
Titanium Dioxide Rutile
We deal in offering a wide range of Titanium Dioxide Rutile which is also known as Titanium Dioxide 'Tipaque' Rutile including CR-50-2, CR-57 and CR-60. Further, we also offer these to our clients in a reliable packaging form of bags of 25 kg. Read more
Delivery to Ahmedabad fromBangalore
All 2
Agriculture grade Sodium Bromate
Detailed Product Description Agriculture grade Sodium Bromate 1) HIgh Quality 2) Resonable price 3) Ontime delivery We offer superior range of high efficient Sodium Bromide powder. These come in white crystalline powdery form. Some of the specifications of these chemical powder are: Read more
Delivery to Ahmedabad fromChennai
Methyl Magnesium Bromide 1.5M Solution in Tetrahydrofuran-Toluene. CAS NO 75-16-1
We specialize in processing, supplying and exporting excellent quality Methyl Magnesium Bromide 1.5M Solution in Tetrahydrofuran-Toluene that has been highly appreciated in the market. This solution is processed by us under hygienic conditions and with the use of advanced equipment. Moreover, we pro Read more
Delivery to Ahmedabad fromMumbai
Mercuric Oxide
A compound of mercury Mercuric Oxide (Red) manufactured by us in LR / AR / ACS grades. Red Mercuric Oxide also known as mercury oxide- red precipitate is insoluble in water and is used in pigments, ceramics and paints. We offer them in approved packaging thus assuring of transport and storage. Spec Read more
Delivery to Ahmedabad fromIndore
Flower Of Life Tulsi Water
Flower Of Life Basil hydrosol or herbal water is anti-bacterial. It can be used as an astringent, skin toner, & facial mist. Basil is considered to be a sacred plant in India and is used extensively in Ayurvedic medicine. Basil/Tulsi hydrosol or herbal water is anti-bacterial in nature and is g Read more
Delivery to Ahmedabad fromHyderabad M.Corp
Citric Acid
We are offering our clients, a wide range of Citric Acids that is known for its non-toxicity and accurate composition. Used in various industries like food & beverage as an accidulant, flavorant & preservative, our range of acids is available in colorless or white crystalline powder. Further Read more
Delivery to Ahmedabad fromSecunderabad
Crude Naphthalene
Ours is a renowned company manufacturing and specializing in a variety of chemicals like Crude Nephthalene used by graphite and refractory sectors of industrial units. This product is made with superior quality raw material and tested among all parameters. Our product range find application in vario Read more
Delivery to Ahmedabad fromDurgapur
All 2
Didn't find required product?
Suppliers will contact you
For last 30 days 107720 leads received the offers from the companies
Bromine in other regions
Whole position
Trading platform Allbiz offers to see the catalog Bromine which contains 3 products offers from 2 companies and enterprises. Don't know what Bromine to buy? You can clarify the specifications, see photos Bromine and choose the best seller and supplier. Buy Bromine trough online ! On Allbiz — You can just place your order right on the site.


text:
Download presentation
Presentation is loading. Please wait.
Published byDarren Symons Modified over 2 years ago
E. Yeşilada 1 ADVERSE EFFECTS AND DRUG INTERACTIONS WITH HERBAL MEDICINES AND SCIENTIFIC EVALUATION OF TOXICITY REPORTS ON HMPs
EACH PLANT IS A MIXTURE OF DOZENS OF COMPONENTS EACH MOLECULE MAY HAVE THERAPEUTICAL or TOXIC or POISONOUS effect Expressions like "HERBALS ARE SAFE ??? or THEY ARE NATURAL THEN NOT TOXIC??? " are illogical E. Yeşilada 2
Paracelsus (16.century) " Difference between the therapeutic and poisonous effects of a particular compound is dose " E. Yeşilada 3
( WHO ) Adverse effects of drugs: " Unwanted or toxic effect observed against a drug when administered in NORMAL DOSAGE for diagnostic purposes, prophylactic or treatment of diseases or to change a physiological response in human " 4 E. Yeşilada
Double-blind clinical studies revealed that; "even through placebo drug administration a wide-range of unwanted/adverse effects may be observed" In 1228 healthy volunteers, percentages of advers effects after placebo drug administration; Single dose administration; 19% Older ages single dose administration; 26% Repeated administration increased the rate to 28% Reported advers effects; headache (7%), lethargy (5%) ve anxiety (4%) etc. Rates may be subjected to change depending on the population and designation of the study 5 E. Yeşilada
Due to the ingredients with toxic effect, high concentration of plant ingredients with potent activity, Falcification/Adulteration: Addition of wrong plant materials Intended/Unintended, Undeclared addition of synthetic active chemicals to strenghten the activity, 7 E. Yeşilada
Contamination with toxic materials; Environmental wastes, Heavy metals, Agricultural agents; pesticides, fumigants, veterinary drugs etc., Microbiological contamination, 8 E. Yeşilada
Wrong pharmaceutical formulation design; Inappropriate excipients selection etc. Wrong procedures in the preparation of HMP: Insufficient denaturation of toxic ingredients, Extraction of toxic components 9 E. Yeşilada
10 Administration in high doses, Long-term administration, Due to a metabolic/physiological deficiency of the patient, Due to personal sensitivity or idiosyncratic reactions, i.e., allergy, irritation etc. II. Risks due to individual factors or sensibility
E. Yeşilada 11 Age-dependent increased risks, Interactions with concurrent therapy, Delayed risks; carcinogenity/mutagenity/teratogenity etc., II. Risks due to personal factors or sensibility
Commercial competition Slanderous claims 12 E. Yeşilada
Multivitamin researchers say "case is closed" after studies find no health benefits 13 E. Yeşilada
E. Yeşilada 15 Are Vitamins realy ineffective?
December 2013: CBS News: 16 E. Yeşilada
Hypothetical suggestions or warnings are postulated based on the composition of the HMP in some sources were quoted to other documents without notifying as hypothetical, and may be accepted as if it is real by others 17 E. Yeşilada
18 E. Yeşilada
Plants/ingredients with powerful physiological activity ; - May have a unique physiological/ therapeutical effect in very low doses, - In higher doses may be dangerous or fatal; -Atropine etc. alkaloids [Nightshade- Atropa sp., Henbane- Hyoscyamus sp.], -Cardioactive components, i.e. digitoxine [Foxglove- Digitalis sp. ] Plant/parts containing toxic components should not be used in phytotherapy: 19 E. Yeşilada
Care should be given in Excessive usages Long term applications High concentrations/doses E. Yeşilada 20
1. Pyrazolidine alkaloids: Hepatic veno-occlusive (HVO) disease Occlusion of the centrolobular veins of the liver, Clinical symptoms in human: abdominal pain, Water-arrest in abdomen, hepatomegaly, Increase in serum transaminases: AST, ALT 21 E. Yeşilada
22 Plants with Pyrazolidine derivatives are prohibited/restricted to be used in formulations Coltfoots; öksürükotu (Tussilago farfarae)
Senecio sp., kanarya otu, liferoot Senecio scandens (unsaturated pyrazolidine alkaloids) In Traditional Chinese Medicine (Qianbai Biyan Pian); prohibited by EMEA E. Yeşilada 23
2. Furanocoumarins : In: Apiaceae (Parsley, celery), Rutaceae (Bergamot, Orange family), Moraceae (mulberry and Fabaceae (beans) Powerful phototoxic activity ; psoralen, bergapten 24 E. Yeşilada
In volatile oils; Bergamot essence is used in perfumes as fixative for a long-lasting scent, Volatile oil contains bergapten, a furanocoumarin, Due to the phototoxic property, increase the sensitivity of skin to sunlight and induce dispersed stains on the skin, in fact burns, This essence was used in some sun-cosmetics for rapid tanning; may induce skin cancer 25 E. Yeşilada Furanocoumarins
Sweden; after large amount consumption of CELERY soup a woman sunbathed under UV-light in a Beauty Center suffered from severe burns. U.K.; after taken large amount of a soup containing celery, parsley and wild carrot the patient was subjected to oral photochemotherapy [PUVA; psoralen and UV-A] suffered from severe burns 26 E. Yeşilada
Large amount of kantaron (St.John's wort) consumption may yield photodermatitis only in calves; Not any report has been found in human E. Yeşilada 27 St.John's wort is used in phytotherapy as an effective antidepressant medicine
28 E. Yeşilada
29 E. Yeşilada Contact dermatitis; eugenol, L-carvone' (mint oil) are the ingredients of toothpaste may induce inflammatory lips in sensitive people, Volatile oil ingredients:
Respiratory irritation; We smell the nice fragrance in cosmetics/ lotions/perfumes/soaps etc. without any harmful effect In Aromatherapists and similar professions continuous /repeated inhalation/exposure may develop intolerence/allergic reactions 30 E. Yeşilada
Apiol : [in Parsley/maydonoz volatile oil] Abortifacient hepatocarcinogenity: in large amounts and long-term "It is very rare to see such toxicities with spices when it is consumed in rational quantities" E. Yeşilada 31 Volatile oil ingredients: in Spices
Camphre/kafur; internally; hepatotoxicity and CNS damage, on skin; neurotoxicity Ointments with camphre (Vicks, etc.) induced hepatotoxicity when applied to the skin of a 2- month old baby in order to reduce the symptoms of catarhh, however, the symptoms recovered as soon as stop application 32 E. Yeşilada Volatile oil ingredients
Ma Huang (ephedrine) from Ephedra sinica Bronchodilatator in asthma and similar symptoms (as doping in sports) OTC: Also is used in formulations to loose-weight or to increase energy in x60 times higher doses. December 2003: FDA ( Federal Drug Administration ) prohibited the use of Ephedrin formulations in USA due to the remarkable adrenergic activity; particularly the symptoms of acute hepatit, halucinations and paranoia. 33 E. Yeşilada Alkaloids
Anthrasen derivatives laxatives (i.e., aloe, senna/sinameki, cascara, rheum/ravent) Used as laxative/purgative in pharmacotherapy (Pursenid®, Bekunis®, Senecod®, Roha®) Long-term application (over 10 days) increase the risk developping colorectal cancer, 34 E. Yeşilada
Kernels/seeds of many edible fruits [ apricot/kayısı, bitter almond/acı badem, cherry/kiraz, sour cherry/vişne, peach/şeftali, pear/armut, prune/erik, apple/elma etc. ]contain cyanogenetic glycosides, 35 E. Yeşilada
Cyanogenetic glycosides: Cyanogentic glycosides are used in food as flavour, in therapy as sedative (2-4 gtt). Hydrolysed in the stomach to yield HCN (cyanhydric acid) and absorbed readily from the upper gastro- intestinal system and may induce sudden death due to respiratory collapse (suffocation), Average 50 mg oral HCN or equivalents; 50-60 apricot kernel in adults or 8-10 in children may induce death. In southeast Anatolia apricot kernels are used as snack after roasted on fire in a pan or in oven until dark color to cleave the toxic principles 36 E. Yeşilada
Licorice/Meyan; Licorice extract from roots has been used widespread as beverage "Meyan Şerbeti" in south Anatolia since centuries. Licorice extract/saponins are precious drug components with a wide range of therapeutic effects: antiulcer, antiviral, anti-inflammatory, antihepatotoxic, etc. Have also been added to formulations to increase bioavailability. Long-term application in high doses induced edema and hypertension in cardiac insufficient patients due to the enzyme inactivation in liver, Due to the inactivation of enzyme metabolizing the endogenous ACTH secreted from the upper- kidney glands, ACTH accumulated in the body and induced edema and then induced hypertension in-turn. 37 E. Yeşilada
38 E. Yeşilada
Botanic identitiy of the plant be problematic with self- controlled plants. Botanic identitiy of the plant may even be problematic in the prepackaged commercially available materials or formulations 39 E. Yeşilada
"Gordolobo" (Verbascum thapsus) case: Latin Americans use the yellow flowers against cough in children as a safe remedy, In USA, a Mexican-originated American bought "Gordolobo" from a local Mexican market The material was obtained from a wrong plant "Senecio longilobus" which is known to possess toxic pyrazolidine alkaloids, Death was reported due to HVO in the baby. 40 E. Yeşilada
Real Ginseng: roots of [Panax ginseng & P. notoginseng]; Effect: increase stamina, physical performance, boost immune system, regulates CNS, regulates metabolism (diabetes, etc.), adaptogen 41 E. Yeşilada
Falcification; - Mandrake (Mandragora officinarum) or Rauwolfia roots, contain alkaloids: toxic - Siberian Ginseng (Eleuterococcus senticosus), roots; Possess a completely different chemical composition,; lignans Used as adaptogenic, weaker activity then Ginseng, In longer administration reported to induce hypertension, and not suggested for hypertensives, 42 E. Yeşilada
1993: Brussel Patients from a "Chinese Slimming Clinic" applied to "Immergency Centers" in hospitals after using a Chinese slimming formulation with the complaints of; Gradually increasing nonspecific fibrosis, tubular atrophy And related kidney disturbances 43 E. Yeşilada
Among 2000 woman were administered the formulation 100> nephropathy 80> connected to dializing unit /or subjected to kidney transplantation 44 E. Yeşilada
In TCM drug plants having the same Chinese name were used ; "Ma Tong"; Clematis sp., Stephania tetrandra, Cocculus sp. Akebia sp.'stems and Aristolochia manshuriensis "Fang-ji"; Stephania tetrandra, Cocculus sp. and Aristolochia fangchi roots 45 E. Yeşilada
In the formulation instead of Stephania tetrandra; Aristolochia fangchi or Aristolochia manschuinsis were used. Aristolochia sp.; contains aristolochic acid Nephrotoxic, carcinogenic and mutagenic E. Yeşilada 46
(2001) France: 7 nephropathy reports U.K.: 2 severe renal insufficiency China: 17 cases and 12 death Japan: 10 renal failure 47 E. Yeşilada
Adverse/toxic effect may be shown; Due to the wrong extraction procedures excessive amount of toxic principle might be extracted, Due to insufficient denaturation of toxic ingredients. E. Yeşilada 48
"Burçak"(Vicia sp.) (müdürmük) seed: hypoglycaemic remedy is used frequently by the diabetics, Contains vasoconstructor proteins, Excess amounts/longer applications may induce symptoms of having the feeling of pins and needles in limbs, even may lead to gangrene, Seeds should be roasted for a while before use for denaturation the toxic proteins in a pan on fire. 49 E. Yeşilada Lack of information regarding the preparation of remedy
Soy beans, reddish-colored bean etc. contain toxic lectins, phytohemaglutinins, and tripsine inhibitors. To remove these components is advised to be boiled at least 30 min in water before cooking and discard the boiled water. 50 E. Yeşilada Toxic components in foods
Potato tubers With the effect of direct sunlight may be turned to green in color indicating that poisonous alkaloids ( solanin etc.) are synthetised. These alkaloids have vasocontructor activity, excess amounts may lead to gangreneous symptoms. Green potatoes should not be used as food Shoots and surrounding parts should be scraped off/removed before using as food 51 E. Yeşilada Toxic components in foods
52 E. Yeşilada
In Hong Kong in a market survey on 14 OTC Ginkgo biloba preparations the level of potential allergenic principle " ginkgolic acid" was investigated: In only 1 preparation was found within the limits suggested by WHO, In 13 prep. Limits were found 16-733 times higher then suggested by WHO. E. Yeşilada 53
These types of contaminations are observed in drugs uncontrolled by official authorities: Unintentional: environmental contamination, During the processing; i.e., extraction incopper caldrons, etc. Intentional: In order to increase acute physiological response undeclared prescription drugs with potent activity may be added, In Eastern Traditional Medicines, i.e., Ayurveda, TCM, heavy metals or certain toxins may be intentionaly added as a part of the treatment 54 E. Yeşilada
Ginseng Improves the physical capacity and other physiological effects only after 15 to 20 days of administration; To provide rapid acute response Caffeine containing extracts [Cola extr., Guarana, Green Tea extr.] or pure caffeine etc. stimulant drugs may be added without any notification on label. Caffeine intoxication may be observed In longer applications or higher doses In hypertensive and related CV patients: Hypertension Gastritic & complaints Nervousness: Agitations, Sleep disturbances, insomnia 55 E. Yeşilada
TCM or Ayurvedic formulations may contain as a part of treatment ; o Arsenic disulfas (realgar), o mercury chloride (calomel), o mercury sulfas (cinnabaris), o red mercury oxide (hydrargyri oxydum rubrum) etc. 56 E. Yeşilada
In at least (32%) were found to possess undeclared Active constituents; i.e., ephedrine, chlorpheniramine, phenacetine, methyltestosterone, etc.) or Heavy metals;i.e., lead, arsenic, mercury etc. 57 E. Yeşilada
In Singapour [1990-1997]; 42 TCM formulations contains high levels of heavy metals, 32 prep. 19 different synthetic active drug agents; berberine, antihistaminics (chlorpheniramine, promethacine, ciproheptadine), NSAIDs (diclofenac, indomethacin, ibuprofen), analgesics-antipyretics (paracetamol, dipyrone), corticosteroids (prednisolone, dexamethasone, fluocinonid), symphatomimetics (ephedrine), broncodilators (teophylline), diuretics (hydrochlorthiazides), antidiabetics (phenphormine) etc. 58 E. Yeşilada
In Turkey (2007 - ) Slimming formulations Contains "sibutramin" 3x higher than suggested dose. Not notified on the label. 59 E. Yeşilada
Microbiologic, Microbiologic, Insect, Insect, Pesticide, Pesticide, Fumigant, Fumigant, Environmental waste, Environmental waste, Heavy metals, Heavy metals, Radiation etc. lar. Radiation etc. lar. 60 E. Yeşilada
In Pharmacopeias plant materials may contain <10 2 -10 4 g/CFU aerobic bacteria/ fungi; Infection rate may increase depending upon the; Incorrect cultivation/growing conditions, Wrong harvesting, i.e., in rainy weathers Inconvenient processing Inconvenient storage conditions Composition of the material, i.e., starch, etc. CFU: colony forming unit 61 E. Yeşilada
62 Dangerous contaminants in HMPs: NOT ALLOWED Patogenic organisms; Enterobacter, Enterococcus, Clostridium, Pseudomonas, Shigella, Streptococcus vd.' Endotoxins and mycotoxins: Aspergillus flavus ; aflatoxins No limit in European Pharmacopeia x 10 times difference in Europe and USA
Pesticides: To protect crop from pests; * Cultivars or * Materials collected nearby to cultivation area; - Chlorinated hydrocarbons; DDT etc., - Organophosphates, - Carbamates, - Polychlorinated biphenyls, etc. 63 E. Yeşilada LIMITS SHOULD BE TESTED
Fumigants: To protect the processed plant material phosphin, 1,3-dichloropropene, chloropicrin, methyl isocyanate, hydrogen cyanide, sulfuryl fluoride, formaldehyde, iodoform etc. - Due to the suspected carcinogenic effect of ethylene oxide is forbidden in Europe, Methyl bromide is restricted due to ozon depleting effect by Montreal Convention. - Should be controlled for imported products, 64 E. Yeşilada LIMITS SHOULD BE TESTED
Contamination with Environmental Pollutants/wastes : Heavy metals : - lead, cadmium, mercury, tallium and arsenic etc. Radioactive wastes; 65 E. Yeşilada LIMITS SHOULD BE TESTED
DRUG INTERACTIONS 66 E. Yeşilada
1. Inhibitory effects on drug metabolizing enzymes May influence on the enzyme profile of the liver/intestines Potentiate the effects of drugs metabolized by those isoenzymes, Creating the potential for an increased risk of side effects; silymarin, licorice, etc. 67 E. Yeşilada
Grapefruit juice, furanocoumarins Inhibitory effect on Cytochrome p450 3A4 in the intestinal wall Leading to decreased first-pass metabolism and increased bioavailability. Metabolism of drugs metabolized through 3A4 enzyme is slowed down Due to the reduced metabolism rate, the rate of unmetabolised drug absorption increased May induce adverse effect/toxicity E.g. Statins 68 E. Yeşilada Inhibitory effects on drug metabolizing enzymes may potentiate the effect of pharmacotherapy
2. Upregulation of drug metabolizing enzymes: Accelerate the metabolism rate and speed of certain drugs, Plasma level of drug has rapidly reduced and may lead to therapeutic failure; MAY BE DANGEROUS IN PATIENTS NEED CONTINUOUS MEDICATION, i.e., St.John's wort Organ transplantation; In order to prevent organ rejection immunosupressants like cyclosporine must NOT be used in the rest of the patients' life, Reduced level of immunosupressants agent in plasma may lead to organ rejection 69 E. Yeşilada
Potentiazation in serotonergic effects may be observed concurrent use of Serotonin reuptake-inhibitors (SRI), [centralin, paroxetine etc.] Concurrent use of MAOI (phenelsine) may induce headache, tremor and mania 70 E. Yeşilada
Digoxin should be continuously provided in certain level in the plasma of cardiac patients, Due to P-glycoprotein induction effect of St.John's wort, plasma level of digoxin may not be ensured 71 E. Yeşilada
72 Drug name Effect Results of interaction Possible mechanism Cyclosporine Immuno- suppresant Decrease in plazma concentration of drug; organ rejection P-glycoprotein induction Ethynyl estradiol/ Desogestrel Oral contraseptive Bleeding Hepatic enzyme induction TeophyllineAntiasthmatic Decrease in plazma concentration of drug Hepatic enzyme induction Phenprocoumone Anticoagulant Decrease in plazma concentration of drug Decrease in anticoagulant activity Hepatic enzyme induction Warfarin AmitriptilineAntidepressant Decrease in plazma concentration of drug Hepatic enzyme induction Indinavir Antiviral (AIDS) Decrease in plazma concentration of drug Hepatic enzyme induction P-glycoprotein induction DigoxineCardiotonic Decrease in plazma concentration of drug P-glycoprotein induction NephazodonSertralineParoxetineAntidepressant Serotonin syndrome Synergistic SRI inhibition
Effect on GI absorption rate: Impairment of renal excretion, Displacement from plasma protein binding sites, Competition for receptor sites, resulting in interference with the pharmacological response. 73 E. Yeşilada
Synergistic effect: Prolonged blood coagulation time (Prothrombine time) In patients receiving oral anticoagulant therapy (OACT)/antiplatelet agents, due to the narrow therapeutic range interference may lead to a medical emercency 74 E. Yeşilada
Plants containing compounds with coumarin-like activity prolong the coagulation time in higher doses/long term administrations Concurrent use of agents of Anticoagulants; Warfarin/ NSAIDs/ with plants with antiplatelet activity, i.e., Ginseng, Ginkgo, Garlic, horse chestnut, etc. should be avoided 75 E. Yeşilada Synergistic effect
Hypoglycaemic shock Plants with Hypoglycaemic activity may potentiate the effect of hypoglycaemic agents; i.e., Ginseng or Garlic, with glibenclamide or insulin 76 E. Yeşilada Synergistic effect
Concurrent use of plants with known Hypertansive effect, i.e., Siberian Ginseng, or licorice would have a negative effect on the antihypertansive pharmacotherapy 77 E. Yeşilada
Long term or high dose administration of herbal diuretics ; May increase the diuretic pharmacotherapy and affect hypotansive/hypertansive treatment Due to loss of potassium, effect of cardioactive drugs (digoxin etc.) may be potentiated 78 E. Yeşilada Hypokalemia may potentiate the effect of Cardioactive drugs
Antracen derivatives of laxatives, in long term administration; May induce reduction in serum potassium level, Potentiate the effect of cardiotonic glycosides (Digoxine, Lanatoside etc.) and antiarythmic agents. 79 E. Yeşilada Hypokalemia may potentiate the effect of Cardioactive drugs
Pre-, Peri- and Post-operative interactions: May induce severe complications Even death 80 E. Yeşilada
Myocardial infarction, Stroke, Paralysis Increase bleeding risk, Insufficient coagulation, Increase in Anesthesia period, Insufficient anesthesia, Interactions with drugs administered during operation, Tissue rejection in Organ transportions, 81 E. Yeşilada
Due to interaction with cyclosporine and St.John's wort (kantaron); acute tissue rejection in 2 heart transplantation cases Concurrent administration of Valerian and kava-kava (CNS sedative), with drugs effective on CNS may increase the anesthesia period in surgical operations; SHOULD BE STOPPED AT LEAST ONE WEEK PRİOR TO SURGICAL OPERATIONS 82 E. Yeşilada
Physiologic discomfort/disease, Genetics, Metabolism rate, Sensitivity, Age, Nutrition, Durability. 83 E. Yeşilada
Immune insufficiency patients; AIDS, tuberculosis, lupus, MS, ALD, leucosis, collagen disease, etc.; Immune-stimulating HMP may induce deterioration in arhtritis etc. complications due to excessive stimulation of autoimmune system 84 E. Yeşilada
Since elimination rates of certain compounds may be affected may lead to severity in symptoms. 85 E. Yeşilada
Oral applications: Sudden Type I hypersensibility reactions; rhinitis, headache, dermatitis, anaphylactic shock, Topic applications; Type IV contact dermatitis, 86 E. Yeşilada
Asteraceae (Daisy family) plants frequent cause of allergic reactions due to sesquiterpene lactones in sensitive people; - Echinacea prep.: Popular and safe immunostimulants against COLD (Chronic Obtructive Lung Diseases) 2 anaphylaxis were reported in Australia, - Feverfew : Effective in migrain pain May stimulate pain in allergic individuals E. Yeşilada 87
Not allowed to use any Herbal remedy during pregnancy and/or nursing, due to low number of randomized studies and lack of scientific data E. Yeşilada 88
Possible interactions Teratogenic, Embryocidal, Carcinogenic, Abortifacient, and other possible adverse effects etc. 89 E. Yeşilada
90 Abortive etffect: Feverfew (Tanacetum parthenium) stimulate menstration, during pregnancy may induce abortion depending on dose
1. Since it is rare to have any information on the effects of an herbal agent on the fetus, their use during pregnancy should be avoided. 2. Little is known about the transfer of active principles in mother's milk for most herbs, so their use in nursing mothers should be avoided. 3. In the absence of specific knowledge of herbals interactions with prescription medications, concomitant use should be discouraged or monitored closely. 4. Except for agents with known estrogenic or androgenic properties, little is known about the effects of most herbs on fertility. 91 E. Yeşilada
5. Oral anticoagulant therapy has always been a corcern regarding drug- drug interactions and this is also true regarding herb-drug interactions. Concomitant use of most herbs should be avoided. 6. Generally there is little known about the effects of continued use over long periods of time. A periodic "resting period" is probably a good idea, but how frequently this should occur, and how long it should be, are a matter of pure speculation given the lack of pharmacokinetic data most cases. 7. There is some corcern about the possibility that herbal medicines may create undue risk in the peri-operative period. Withdrawal 7-10 days prior to surgery may be advisable for most herbs, but in some cases, for example Valerian, a gradual reduction in dosage may be necessary. 8. Children generally are not good candidates for herbal therapy. They may have greaer relative exposure, less well-developed biotransforming enzymes, a higher rate of cell division, making them more vulnerable to mutagenesis. 92 E. Yeşilada
Many of the adverse effect and toxicity reports are due to Insufficient standardization Scanty control Falcification High-dose applications Long term administration Individual factors; sensitivity, function disorders 93 E. Yeşilada
Similar presentations
© 2017 SlidePlayer.com Inc.
All rights reserved.


text:
Download presentation
Presentation is loading. Please wait.
Published byEvan Bevel Modified over 2 years ago
Attitudinal Segmentation – Survey Method
1.Whom to Interview. In a survey of finding segments of customers who are travelers / tourists to Europe, it is not appropriate to count only those who have been to Europe, because that accounts for a small percentage. You have to talk to potential travelers 2.Frame of reference for questioning When you are questioning customers on vacations do you take (a) overall experience of vacations (b) last vacation 3.Find different ways of segmentation For example : Vacation to Europe, segment on (a) Favourability towards Europe (b) Segmenting on Income brackets © segmenting customers based on desires sought on their last vacation In a study on 1750 interviews for vacationing the following segments were Uncovered – (1) visit friends and relatives segments (2) good for family sight- Seeing (3) outdoor vacationeer (4) resort vacationeer (5) foreign vacationeer
Shells Customer Segmentation study Methodology Surveyed 5000 respondents in 6 markets. Questions included * Behavior patterns * Desired Features * Frustrations * Brand Ratings * Psychographics * Demographics * Statistically identified 10 distinct Clusters of customers with different needs/ attitudes Studied Survey results from each cluster Developed name and personality for each cluster Source:Wharton School
Shell Customers Target Segments and Characteristics Premium speedsters 13% Struggling survivors 9% Value minded Planners 6% Safety firsters 6% Sentimentalist 13% Comfort Zoners 15% Relationship shoppers 13% Low octane communicators 7% Hands-on individualists 12% Simplicity seekers 11% Source:Wharton School
Segments selected Premium speedsters Simplicity Seekers Personality: Overburdened, Frustrated, Loyal to others, caring, sensitive. Hard to motivate. Gas Purchasing: Reactive. Want things that make buying gas easy. Major brand= product reassurance. In a Word…Overwhelmed Safety Firsters Personality: Confident, Self- assured, Responsible Control oriented, well prepared. Gas purchasing: want cleanliness, comfort, Efficiency, safety In a word….Safety Minded Source:Wharton School Personality : Internally driven, Competitive Mentality Gas Purchasing :Fast pumps, quick access In a word:Power minded
Brand Identities Considered One stop convenience (Value minded planners, struggling survivors) Friendliest Service (Relationship Shoppers, Comfort Zoners) Community support (Comfort Zoners) Lowest Price (Low octane commuters, Sentimentalists) Best Gasoline performance (Hands on individuals, premium speedsters) Quick & Easy ( Premium speedsters, simplicity seekers, safety firsters) Source:Wharton School
Market Targeting
Single Segment Concentration Zodiac concentrating on executive and professionals Selective Specialization – may be or may not be Synergy among the segments selected HLL in Soaps Product specialization - Specialized product to several segments – TVS makes scooters of all ranges to several socio-economic classes Market specialization – Serving many needs of a single customer group. Financial services to NRIs Full Market Coverage - General Motors,
What is Positioning
To some it means the segmentation decision (economy and premium segments). To others it is an image question (Casual, sporty wear – Benetton) To still others it means selecting which product features to emphasize – (flavor or foaminess of toothpastes) Positioning a brand is obtaining mind-space of the consumer for the brand with Respect to competition Positioning is the act of designing the companys offering and image to occupy a distinctive place in the mind of the target market so as to maximize the Potential benefit to the firm. The result of positioning is the successful creation Of a customer focused value proposition e.g. – Colgate Total – Multi-benefit toothpaste as a one product solution for people with tooth problems As against Colgate Dental Cream – Core Identity for strong, white teeth meaning a toothpaste to maintain healthy teeth.
Jack Trout issues on Positioning
1.Embrace the obvious position possible in the market or granted by the market. Positioning should be in line with the perception of consumers mind not against it Coke:The Real Thing is fine; it is the original cola Coke:Always Coca-Cola may not be fine as half the market is Pepsi 2.Many positioning ideas are founded on how company estimates the future Samsung – Challenging Limits – Looks alright Avis:We are No.2. We try harder 3.Be Simple:Volvo – Drive Safely 4. Positioning is long term. Do not be driven by the stock market
Kotler et.al on Positioning
Steps to a Positioning Strategy
1.Determine Target Market Laptop for the business professional 2.Determine category membership of the brand under consideration Hewlett Packard dv1000 is a sophisticated business laptop 3.Identify the competition Sony, Toshiba
4.Establish the Category Points of Parity to fulfill the necessary conditions of category membership there are three main ways to convey a brands category membership - announcing category benefits centrino mobile technology - comparing to exemplars on par with HPs excellence in instrumentation - relying on the product descriptor HP Pavillion dv1000 is an entry level business laptop
5.Establish the Competitive Points of Parity to establish the equivalence of Product benefits, attributes, values with respect to competition HPs manufacturing quality is no way behind Sony or Toshiba. It is backed by decades of manufacturing electronic systems
6. Establish the Points of Difference if any to take a differentiated position If no POD exists then the brand takes a head on position or a me-too position HP has an excellent service network in India as compared to Toshiba. HP is not as expensive as Sony 7. Write out the Positioning Statement To the young urban professional (target market) our product – HP Pavilion dv 1000 is a rugged system with all the necessary features of a state- Of-art business computer and is offered as a value for money laptop with Excellent service backup.
Important considerations in choosing Points of Difference (PODs) (1) PODs are desirable by the customer - Relevant and important to the customer – e.g. price of HP Laptop - Distinctiveness – Service backup is not a common feature of all foreign made laptops in India - Believable – HP has been in the electronic business for decades
(2) PODs are deliverable to the customer - Feasibility – HP has the required organization to make the service deliverable and the required technology to offer a value for money product - Communicability - HPs products are not known as very expensive - Sustainable - HP has the required R&D to continue making state-of –art upgrades In this case PODs are anchored at the benefit level, sometimes they could be Anchored at the attribute or value level
Handling Conflicting POPs and PODs Sometimes attributes and benefits are negatively correlated or move in the opposite Direction. Ideally consumers want to maximize their benefit package. Examples of such cases are (1) Low Price vs High Quality (2) Taste vs Low Calories (3) Nutritious vs Good Tasting.
Methods to overcome such situations - Go for straddle positioning – do both simultaneously. BMW designed its car for both luxury and performance - Present the communication messages for each attribute / benefit Separately - Leverage equity of another entity e.g. Intel Inside - Redefine the relationship – Teach customers that the relation between attributes is redefined and now stands positive e.g. Apple is user friendly and not regarded as powerful. Apple came up with an ad campaign that had the tag – Power to be your best, teaching customers that they used it because it was user friendly and having used it successfully it was powerful.
Differentiation It is the process of adding a set of meaningful and valued differences to Distinguish a companys offering from competitor offerings A difference will be stronger if it satisfies one or more of the following criteria 1.Important - Infrastructure investment of business school 2.Distinctive, but not necessarily superior - Bajaj scooter 3.Superior - Product superiority of Gillette 4.Preemptive - cannot be easily copied - Zilog Processor 5.Affordable - Personal Computer of Acer 6.Profitable - MTRs food products
Dimensions on which differentiation can be achieved by firms 1.Product / Services 2.Personnel 3.Channel 4.Image
Product / Services -Product / Service Quality performance based – BMW conformance quality – CMM in software physical signs and cues – Tata Indica - Form- Satchets -Features – Cameras -Durability – Volvo - Reliability – Maytag -Repairability – Maruti -Style – Benetton -Design – Designer wear Services -Ordering ease – home delivery pizzas -Installation – Mobile -Customer Training – GE Medical Systems - Customer Consulting -Saree selling - Maintenance and repair – Premium apartments in the city.
Personnel - Trained personnel should exhibit the following -Competence – Repair engineers of process plants - Courtesy - Front line staff in premium hotels -Credibility – Premium hospital doctors - Reliability – Parallel computers -Responsiveness and Communication – Beauty Consultants
Channel - Coverage – HLL - Expertise – Avon - Performance - Caterpillar Image - Differentiate Identity – Mysore Sandal Gold vs Dove - Differentiate Logo, colors, slogans, events and sponsorships – Coca-Cola
Products, New Product Development Process, Branding
a.Corporate product portfolio including mergers and acquisition decisions and changing portfolio b.SBU product portfolio including design of new product development process and product deletion decision c.Product line positioning, width and depth of product line, product modification d.Brand positioning Factors affecting product decisions - the consumer - the competitors - the environmental factors - firms own objectives and resources Illustrative Product decisions
Understanding Products
Product A product is anything (bundle of benefits) that can be offered to a market to satisfy a want or need. An offering consists of the product features / Quality, service mix/quality, value based price. Products include - physical goods (automobiles), services (musical concert), persons (electoral candidate), Experiences (air journey), events (cricket match), tourist places (Kashmir), Properties (Leela Penta Hotel), organizations(hospitals), information(trade Shows) and ideas(family planning)
Core benefit - Transport Analysing the Five Product Levels – Indica Automobile Basic Product - 4 wheel closed car Expected product - good performance - all specs in the ad in small letters Augmented product - wants beyond expectations - best after sales service even though not required Potential product - possible evolution for the car of tomorrow CUSTOMER VALUE HIERARCHY
Classification of products Fdurability, tangibility basis èdurables, nondurables/consumables, services Fuse basis èconsumer, industrial, military, government
Industrial goods è raw materials and parts natural and manufactured raw material, components, subassemblies/modules, semi-knocked down kits è capital items Installations - buildings and plant Equipment - portable factory equipment and office equipment turnkey projects è supplies / consumables and business services operating supplies (paper, lubricants); maintenance/repair items (paint) and maintenance / repair service(Copier repair), business advisory services (legal, management consulting, advertising)
Consumer Goods Classification Convenience goods - staples (soaps), impulse (gum) emergency (umbrellas) Shopping goods - homogenous (fans, food mixers - price significant), heterogenous (textiles, furniture - non price issues also signficant) Specialty goods - goods with unique characteristics or brand identification - cars, cameras Unsought goods - Special selling effort reqd - encyclopedias, life insurance.
Product Hierarchy Need Family:Personal Transport Product Family:Automobiles Product Class:4 wheelers Product Line:Passenger cars Product Type:Mid size car Brand:Maruti Item:Esteem AX
Product mix width - partial Deodorants Bar Soap Coffee Detergents Tooth paste Ivory Camay Lava Kirks Zest Safeguard Coast Oil of Olay Product Line length for Bar soaps Gleem Crest Product Line length for Toothpaste P&G Product-Mix vs Product line Crest comes in two formulations and three sizes and so has a depth of six P& Gs product lines are consistent (closely related to each other) in distribution PRODUCT SYSTEM – PC +PRINTER+ OPERATING SYSTEM + APPLICATION S/W + MOUSE
Major elements of managing products Product Life Cycle Product Portfolio Analysis Objectives of Product Portfolio Analysis Product Line Management
Product Life Cycle
Making the PLC Operational / Issues to Look at PLC 1.Unit of Analysis – Product Class, Product Form, Product Line….. 2. What is the relevant market to which the PLC applies Relevant Product Market + Relevant Geographic Market 3.What is likely lifecycle pattern to emerge - fad, fashion, style, cycle-recycle, staple 4.Identifying the products stage in the PLC Model 5. Unit of measurement of PLC – unit sales, rupee value 6. Develop PLC on weekly, monthly, quarterly or annual data
Empirical Generalization: Always (Almost) Looks Like a Bass Curve
Color TV Forecast 1966 Peak in 1968 Industry Built Capacity For 14 million units
An Empirical Generalization
Another Example 35 mm Projectors
Another Example: Overhead Projectors
Capture Law- DRAMS Norton and Bass: Management Science (1987) Sloan Management Review (1992)
Capture Law-Mainframes-Beautiful!
Generations of PCs
Effects of Different Prices
Product Portfolio Analysis
Objectives of Product Portfolio Analysis 1)Resource allocation among products and markets 2) portfolio analysis of competitors leads to a refined understanding of competitive strategy by action – reaction steps 3)Assess the marketing effort for each product to direct it in the product portfolio from one place to another
Boston Consulting Group- Growth share matrix. STARSPROBLEM CHILD CASH COW DOG MARKETGROWTHMARKETGROWTH RELATIVE MARKET SHARE High Low HighLow
Shell International directional policy matrix Prospects for sectors profitability UnattractiveAverageAttractive Companys Competitive Capabilities WeakDisinvestPhased withdrawal custodial Double or quit Companys Competitive Capabilities AveragePhased withdrawal Custodial Growth Try harder Companys Competitive Capabilities StrongCash generation Growth leader leader Competitive capabilities- Market position - Production Capability - Product R &D
Mc Kinsey/GE Business Array Industry attractiveness – Size, Market Growth, Pricing, Mkt. Diversity Competitive Structure, Industry Profitability Business strength - Size - Growth - Share - Position - Profitability - Margins - Tech. Position - Image - People HighMediumLow HighInvestment and growth (G) Investment and growth (G) Selectivity/ Earnings MediumInvestment and growth (G) Selectivity/ Earnings Harvest LowSelectivity/ Earnings Harvest
Product performance matrix Company salesDeclineStableGrowth Industry sales Profitability MKT share Below target TargetAbove Target Below target TargetAbove target Below target TargetAbove target GrowthDominant average Marginal StableDominant average marginal DeclineDominant average Marginal
Product Line Management Product Line analysis Product line length management
Product Line Analysis Study sales and profits of each item in line, to see Which to build, maintain, harvest, divest. Do ABC Analysis on sales / profits Core products – Basic Computers – low margins Staples – CPUs, Memory chips – higher margins Specialties – digital movie equipment – still higher margin Convenience items – monitors, printers –high volume high margin Manage each of the above four types of products differently Market Profile: Examine how the line is positioned against Competing lines. Understanding corresponding competing Products between your line and competitors line. Understand Gaps in product line and understand market segements
Product Line Length Management Product line objectives would be to induce both up selling and cross selling High Market share seeking firms will have longer product lines. High profitability seeking firms will have shorter lines of important / more profit product items.
Product line length Management Line stretching Upward – Maruti – 800, Omni, Esteem, Baleno, Toyota - Lexus Downward – Surf – Wheel Two way - Rural Transport Vehicle – Ambassador – Mitsubishi Lancer (Hindustan Motors) Texas Instruments in Hand Calculator Line Filling (each item should produce a just noticeable difference) TVS TVS Scooty --- TVS SUZUKI Mobike Line Featuring: (oft promoted brand in line) Lux in Soaps for HLL Line modernization – Intel in Microprocessors Line Pruning – First Ruf & Tuf ready to stitch kits. Later Ruf & Tuf Jeans
Developing New Products Firm end òNew Product Development Process Consumer end òConsumer Adoption Process
New Product Development Process Make or Buy Decision Issues to New Product Development Steps to New Product development Process Factors for success of new product launches New Product Strategies - Reactive and Proactive Some reasons for new product failures
Make or Buy Decision Considerations 1. Timing Considerations 2. Superiority of Buy technology 3. Cost considerations 4. Management, Legal and Market feasibility
Similar presentations
© 2017 SlidePlayer.com Inc.
All rights reserved.


text:
seek timeRefers to the time a program or device takes to locate a particular piece of data. For disk drives, the terms seek time and access time are often used interchangeably. Technically speaking, however, the access time is often longer the seek time because it includes a brief latency period.
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
Like everything in technology, AI touches on so many other trends, like self-driving cars and automation, and Big Data and the Internet of Things... Read More »DevOp's Role in Application Security
As organizations rush to release new applications, security appears to be getting short shrift. DevSecOps is a new approach that holds promise. Read More »Slideshow: Easy Editorial SEO Tips to Boost Traffic
This slideshow reviews five easy on-page editorial SEO tips to help drive organic search engine traffic, including the page title, heading,... Read More »
Java is a high-level programming language. This guide describes the basics of Java, providing an overview of syntax, variables, data types and... Read More »Java Basics, Part 2
This second Study Guide describes the basics of Java, providing an overview of operators, modifiers and control Structures. Read More »The 7 Layers of the OSI Model
The Open System Interconnection (OSI) model defines a networking framework to implement protocols in seven layers. Use this handy guide to compare... Read More »


text:
Comedy, Games & Hobbies, Video GamesFollow
|Video Games
|Games & Hobbies
What's going on, Internet!? Prepare for some of the most insane rambling about everything from life, to sex, to what passes for 21st-century Internet culture. Your aural canals are ours, and we're running a train on 'em -- courtesy of hosts Brian Altano, Scott Bromley, Anthony Gallegos, Ryan Scott, and Max Scoville. BRAAAP BRAAAP! New episode every Friday afternoon!
Parental Advisory
May 17th, 2013
Episode 83 of 278 episodes
In this episode, we read real raccoon facts, discover that tripping a person will give them a speech impediment, mess around at work, watch things fail, learn how awesome the Internet is, break down the top 25 horses in gaming, have some very bad accidents at a horse race, build cyborgs to fight each other, and wonder whether the real world is better than college. Starring Scott Bromley, Brian Altano, Anthony Gallegos, Ryan Scott, and Max Scoville.
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


text:
6 St. Louis Blues score goals in 6-1 rout of Maple Leafs (The Associated Press)
- Updated: March 8, 2015
All night it seemed the St. Louis Blues had an extra player on the ice. St. Louis swarmed, scored and out-classed Toronto at every turn, with six Blues scoring goals in a 6-1 rout on Saturday night. "There was no effort," interim coach Peter Horachek said as the Leafs lost for the 28th time in 35 games. "There's no real excuses for it, so I'm not going to make any." Jori Lehtera and Alexander Steen each had three assists for the Blues (41-19-5), who snapped a two-game skid and moved to within two points of the Central Division-leading Nashville Predators.
← Previous Story Flyers-Devils Preview (The Associated Press)


text:
Bring your camp to Camp LQ! Easy to plan. Exceptional fun!
Whether you're kicking off the season or having a wrap-up party. LQ is the best game in town!
Bring your camp to Camp LQ! Easy to plan. Exceptional fun!
Whether you're kicking off the season or having a wrap-up party. LQ is the best game in town!
Welcome to Laser Quest Wichita
(316) 652-9500
Get ready for some great family fun and entertainment! We are conveniently located at the corner of 21st Street and Woodlawn.
Reservations are recommended. Laser Quest Wichita is open for private events outside regular business hours. Frequently Asked Questions.
Tag as many people as you can without getting tagged yourself. You'll experience heart-pumping excitement that takes approximately 30 minutes from the time you get your codename, don your pack and pick up your scorecard. It's 15 minutes of playing time that combines the classic game of hide-and-seek and tag with a high tech twist.
Experience double the playing time in our multi-level arena for one great price! An Ironman Mission includes 30 minutes of heart-thumping playing time with swirling fog, energetic music and fun waiting around every corner. Expect to be at the Centre for approximately 45 minutes to one hour from the time the Ironman Mission begins to when it finishes, including the distribution of your scorecard. Will you be the next Ironman Champion?
Key Quest is an introductory live action escape room presented by Laser Quest. Our single room experience requires observation and critical thinking skills to find clues, solve a series of puzzles, and ultimately, discover the "key" to escape the room within 45 minutes.
Classic Package - $17 per player
Premium Package - $27 per player
Weeknight discounts available - Ask us how!
Classic Birthday Package
Premium Birthday Package
Sports Teams
School Field Trips $15.00 per person
View Youth Group Packages
View Sports Team Packages
View School Trip Packages
View Packages
View Packages
View Packages
Applicable taxes are extra.
Laser Quest combines hide-and-seek and tag with a high tech twist. Our multi-level arenas have swirling fog, energetic music and fun waiting around every corner! Looking for adventure, mystery
and an unforgettable experience?
Ask us about Key Quest, Laser Quest's Escape Room experience.
Connect with us!
|Connect with us on Facebook.
|Follow us on Twitter.
|Check us out on Instagram.
|Watch us on Youtube
|Snap with Us on Snapchat
Hover over a date to view promotions & hours
|Regular Hours
|Extended Hours
|Open for Private Group Events & Future Reservations
|Public Events and Regular Hours
We will open any time for your pre-booked private event!
Open extended hours during holiday periods.
Reservations are always recommended.
Key Quest, The Live Action Escape Room Experience
Enter a themed and mysterious room. Solve a series of puzzles using logic, knowledge, communication and teamwork.
March Madness & Mayham Overnighter - Fri. Mar. 17th
Midnight to 7am
$35 per person with a reservation or $40 per person on the day of the event. Reservations are recommended. All reservations must be made 24 hours in advance for discounted pricing. Enjoy speciality games all night long!
Spring Break Triple Play - Fri. Mar. 17th to Sun. Mar. 26th
Call (316) 652-9500 to reserve your spot today!
Play 3 action-packed games of Laser Quest for $19 plus tax per person. Reservations are recommended. All three games must be played by the same person on the same day.
Call Us Now - (316) 652-9500
2120 N. Woodlawn
Wichita, KS 67208
We would love to hear from you!
Please complete the form below:


text:
Please join the Arenac Conservation District on February 16, 2017 at the Deep River Township Hall in Sterling.
Dinner will be at 6:00 p.m. $5.00 per person. The Annual Meeting and the election of one board of director, Tim Hagley for a 4 year term, the meeting will start immediately after the meal along with partner updates, Conservationist of the year, Farmer of the Year, Youth Awards and Guest speaker. Residents are individuals of legal age who can demonstrate residency in the Conservation District via one (1) piece of identification.
Absentee ballots are available for voting in this election by writing to or calling the Conservation District Office located at 4490 W. M-61, Standish, MI, 48658 phone 989-846-4566 ext. 5 during the regular business hours of the District which are between the hours of 9 a.m. and 3 p.m.
Please RSVP no later than February 13, 2017 (to ensure we have enough food on hand for dinner) at (989) 846-4566 ext. 5. We hope to see you there.
Timothy Hagley, Chairman of the Board of Directors
Arenac Conservation District
Standish, MI, 48658
ext. 5
Tim Hagley Board Chairman
Dick Dell Vice Chairman
Steve Balicic Board Member
Earl Steinbauer Board Member
Tony Czymbor Board Member
Earth Team Volunteers
Earth Team Volunteers help with everything such as
Not sure what you want to do?Contact us today!
Dawn Hergott - Administrator
Amanda Brown - MAEAP
Anne Collins - Forester
We offer adult and youth education programs
Visit our programs-
we have for
land stewards of all kinds!
We have three technicians that work the programs
MAEAP, Forestry,
Farm Bill Biologist, CREP and Pheasant programs.
Arenac Conservation District
Arenac Conservation District Office
2nd Tuesday of each month
9:30 a.m. (unless otherwise stated)


text:
INVESTMENT OR OWNER OCCUPIED, CONVENIENCE & CHARM BLENDED INTO THIS DUPLEX. 2 Units, Each Bursting W/Amenities! First Floor Unit Has 2 Sizable BRS, Spacious Living Room & Charming Eat-In Kitchen. Upper Unit Has 2 Over Sized BRS, LR, Kitchen. This Duplex Includes 2 Stoves, 2 Refrigs, 2 Washers & 2 Dryers, 2 Secure Storage Areas, 2 Car Garage. Unlimited Possibilities Waiting For You.
Features Multi Family
|Total Number of Units: 2
|Estimated Age: 1906
|Total Lot Square Feet: 0
|Unit 1 Parking: 1 Car Garage
|Taxes: $1,837
|School District: Waupun
|Body of Water:
Estimate your monthly mortgage payment
How much can I borrow?
Apply online: www.shelter-mortgage.com
Speak with a mortgage consultant: 800-981-8139


text:
Ericdress Casual Plain Falbala Blouse
Ericdress Unique Print Long Sleeve Plus Size Men's T-Shirt
Here ericdress.com shows customers a fashion collection of current valentines day black leather flat boots for women.You can find many great items. They all have high quality and reasonable price. You can get big discount sometimes, because we always do promotions. If you need valentines day black leather flat boots for women,come here to choose. We give you good items and services.
OL Style Patent Leather Grid Handbag for Women
Black PU Leather Multilayer Necklace
Ericdress Long Black Leather Tassels Necklace
Ericdress Five Opal Butterfly Black Leather Necklace
Fashion Black Leather Stiletto Heels Knee High Boots
Ericdress Patent Leather Thread High Cut Men's Boots
Ericdress Patent Leather Point Toe Flats
Charming Rhinestone Genuine Leather Flat Sandals
Ericdress Fashion Leather Band Women's Quartz Watch
Ericdress Personality Wavy Artificial Leather Bracelet For Men
Ericdress Solid Color Nubuck Leather Shoulder Bag For Men
Ericdress Patent Leather Martin Ankle Boots
Ericdress Warm Patent Leather Men's Martin Boots
Ericdress Patent Leather Platform Thigh High Boots
Ericdress Patent Leather Lace up Martin Boots
Ericdress Patent Leather Knee High Boots
Ericdress Patent Leather Platform High Heel Boots
Vintage Patent Leather Croco Handbag
Ericdress Preppy Washable Leather Handbag
Ericdress Full Rhinestone Leather Bracelet
Ericdress Patchwork Waxy Leather Backpack
Ericdress Black Patent Leather Stiletto Sandals
Ericdress Personality Black Wide Leather Men's Bracelet
Leather Stiletto Heels Women Shoes


text:
The Status of Lipid Management in 1,836 Patients with Coronary Artery Disease : A multicenter survey to evaluate the percentage of Japanese coronary artery disease patients achieving the target low-density lipoprotein cholesterol level specified by the Japan Atherosclerosis Society
To determine the status of lipid management in patients with coronary artery disease (CAD) in Japan, we assessed CAD patients who had been receiving lipid-lowering therapy for six months in a cross-sectional survey conducted between June 2001 and December 2002. We defined the achievement rate as the percentage of patients who achieved the target LDL-C level (< 100 mg/dl) specified by the Japan Atherosclerosis Society (JAS). A total of 1,836 Japanese CAD patients were enrolled. In total, 549 (29.9%) achieved the target level. The achievement rate among those receiving statin therapy was 41.3%, which was significantly higher than that (23.4%) among the patients not receiving statin (P < 0.0001). The rate differed with the type of statin; being 54.7% for atorvastatin, 24.8% for pravastatin, 37.1% for simvastatin, and 27.8% for fluvastatin. A multiple regression analysis revealed that atorvastatin use (P < 0.001), and simvastatin use (P = 0.004) significantly contributed to the achievement of the target LDL-C level. In conclusion, large proportions of CAD patients are not achieving the JAS target and the success rates are not similar among different statin therapies, suggesting that cardiologists should consider a more aggressive lipid-lowering therapy with the appropriate choice of statins in Japanese CAD patients.
- Journal of atherosclerosis and thrombosis
Journal of atherosclerosis and thrombosis 12(6), 338-342, 2005-12-25
Japan Atherosclerosis Society


text:
Czech translator needed - Repost
This project has been awarded to committed for $250 USD.Get free quotes for a project like this
Project Budget$250 USD
Total Bids1
Project Description
Dear Sir or Madam,
To begin with, I would like to translate your text to Czech. Some details about me: my name is Paula, I´m native czech speaker, 20 years old and I have some experiences while studying English, I pass FCE Cambridge exam and now I´M prepairing for CAE and the other. Nevertheless, I study English and German at the university.
I´m looking forward to hearing from you.
Awarded to:
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
DEFINITION of 'Lehman Brothers Government/Corporate Bond Index'
An unmanaged market-weighted index, comprised of government and investment grade corporate debt instruments with maturities of one year or greater. The Lehman Brothers Government/Corporate Bond Index is a total return benchmark index for many bond funds.
BREAKING DOWN 'Lehman Brothers Government/Corporate Bond Index'
The Government/Corporate Bond Index is a subset of the Lehman Aggregate Bond Index. Lehman determines if a bond is investment grade by its listed credit rating by Moody's. Investment grade bonds have a rating of Baa or higher on the Moody's scale. If the bond is unrated by Moody's, an S&P rating of BBB or higher will suffice. The index's measures performance by total return, which includes the capital appreciation or depreciation of the bond, combined with its coupon income as a percentage of the original investment.
Lehman Aggregate Bond IndexAn index used by bond funds as a benchmark to measure their relative ...
Total Bond FundA mutual fund or exchange-traded fund that seeks to replicate ...
Bond RatingA grade given to bonds that indicates their credit quality. Private ...
Bond Buyer 20A representation of municipal bond trends based on a portfolio ...
Bond Buyer 11An average yield on a particular day of 11 selected general obligation ...
BondA debt investment in which an investor loans money to an entity ...
What does Investment Grade Mean?Investment grade is a term used to describe a favorable rating for corporate and municipal bonds.
Explaining Bond RatingsA bond rating is a grade given to a bond to indicate its creditworthiness.
Case Study: The Collapse of Lehman BrothersLehman Brothers survived many financial crises in its long history. Find out what finally drove it to bankruptcy.
The Basics Of BondsBonds play an important part in your portfolio as you age; learning about them makes good financial sense.
Small Business
Lehman Brothers: The Largest Bankruptcy Filing EverLehman Brothers survived several crises, but the collapse of the U.S. housing market brought the company to its knees.
Investment Grade Fixed Income in Your PortfolioIf you are worried about rising interest rates, consider these investment grade bond alternatives.
Corporate Bond Basics: Learn to InvestUnderstand the basics of corporate bonds to increase your chances of positive returns.
How To Choose The Right Bond For YouBond investing is a stable and low-risk way to diversify a portfolio. However, knowing which types of bonds are right for you is not always easy.
Financial Advisor
Advising FAs: Explaining Bonds to a ClientMost of us have borrowed money at some point in our lives, and just as people need money, so do companies and governments. Companies need funds to expand into new markets, while governments need ...
Financial Advisor
Top 5 Corporate Bond Mutual Funds (DEECX, FCBFX)Learn about the top five mutual funds that invest in corporate bonds that have investment grade quality and speculative credit ratings.
What are the highest-yielding investment grade bonds?Learn how Standard & Poor's and Moody's rate bonds. Understand what investment grade bonds offer the best yield. Read Answer >>
How are junk bonds rated differently by Standard & Poor's and Moody's?Learn how credit rating agencies rate bonds with junk bond status, and understand how downgrade risk can impact the price ... Read Answer >>
Where can I find information about corporate bond issues?Learn information about corporate bond investments, including where investors can access information about new corporate ... Read Answer >>
What forms of debt security are available for the average investor?Discover the various different types of debt securities, issued by government entities or corporations, that are available ... Read Answer >>
What bond indexes follow the supply and demand for junk bonds?Learn about indexes that track junk bonds, why junk bonds pay more interest than other types of bonds, and how these bond ... Read Answer >>


text:
Authentic Manhood Australia
Personal Development, Life Coaching, Counselling Service
Authentic Manhood Australia provides crisis counselling, personal development and life coaching services carefully tailored to the unique needs of men. Information and bookings can be obtained from our website.
We also offer marriage and family counselling sessions that cater effectively to all parties involved.
Print this page
Empowering men to reach their full potential!
Purchase from a range of carefully selected books that support personal growth in men.
For men wanting to check-in regularly and continue the journey of self discovery, AMA runs a fortnightly group for men.
If you are in crisis, a time of change or just want to be all you can be, our three day retreats, led by highly experienced facilitators, offer the opportunity to pause and examine your life in a relaxing and inspiring environment.
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
Lightwater Quarries
Mining And Quarrying, Heavy Building Materials, Sand Gravel
Lightwater quarries has re-opened its Gebdykes operation, after Michael Pye joined the team at Lightwater as Sales Director it was decided the time was right to begin production at our second quarry again. With a busy market and economic recovery in the construction industry Andy Parker our Operations Manager and the team have all got stuck in to operating the quarry effectively to ensure a great quality Limestone product.
Print this page
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
F3, a free all-male bootcamp, happens twice weekly in Audubon Park. Continue reading »
F3, a free all-male bootcamp, happens twice weekly in Audubon Park. Continue reading »
A pharmacy at Nashville Avenue and Magazine Street that was open in spite of the power outage following Monday's storms in New Orleans was robbed at gunpoint of cash and painkillers by three masked men on Tuesday afternoon, police and the victims said. Continue reading »
New Orleans College Prep will present its spring concert to honor New Orleans' musical legacy on Wednesday evening at Cohen High School. Continue reading »
The Preservation Resource Center of New Orleans will dedicate Professor Longhair's former home as a museum o Wednesday in a dedication ceremony complete, of course, with an array of local musicians. Continue reading »
Ben Franklin Elementary and Lusher High School still have no power following Monday's storms and will remain closed Tuesday, school officials said. Continue reading »
Three construction workers escaped from a home just off Wisner Park moments before it collapsed amid the high winds during Monday morning's storms in New Orleans, they said. Continue reading »
See below for live coverage via Twitter of the aftermath of Monday's storms around Uptown New Orleans from UptownMessenger.com.
Thousands of Uptown New Orleans residents lost power on Monday morning as strong storms brought a tornado watch to the city, according to Entergy maps. Continue reading »
In case of emergency, call 911. Then wait. And wait. And wait.
If you wait long enough, there's some chance the line will just disconnect. Then you can try again. Repeat as necessary.
This was certainly the lesson learned by onlookers to a shooting this past Wednesday in the Lower Garden District on Magazine Street. The pair, two workers toiling away in an nearby office, heard the sound of gunshots and then peered out the window to view the aftermath. There, they saw some men scrambling. Thankfully, nobody was hit.
Both of the witnesses dutifully called 911. The first waited for nearly three minutes for her call to be answered. The other waited the same amount of time… only to be disconnected. Continue reading »


text:
From Longman Dictionary of Contemporary Englishgraspinggrasp‧ing /ˈɡrɑːspɪŋ $ ˈɡræs-/ adjective GREEDYtoo eager to get money and unwilling to give any of it away or spend it Hanson was a hard, grasping man.
Examples from the Corpusgrasping• He seems like a good guy to me, not at all the usual grasping political type.• She had tried to be hard and grasping, tried to deal with this in a sophisticated, detached manner.
More resultsSee all results
Pictures of the day
Explore topicsSee all topics
Word of the day priceless extremely valuable


text:
Comedy, Games & Hobbies, Video GamesFollow
|Games & Hobbies
|Video Games
Every week, the creators of Two Best Friends Play discuss the best and worst of the videogame industry, pop culture and get excessively hyped about things for no reason.
Parental Advisory
September 21st, 2016
Episode 164 of 186 episodes
Austin Creed aka Xavier Woods of UpUpDownDown tries to makes sense of the giant mistake that is the Super Best Friendcast.
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


text:
Watch Suits Season 1 Episode 1 online
Suits Season 1 Episode 1 rainierland, In the premiere of this legal drama, successful lawyer Harvey Specter (Gabriel Macht) hires brilliant college dropout Mike Ross (Patrick J. Adams) as a new associate at a top law firm despite the fact that Mike doesn't have a degree. In order to work together, both parties have to keep up the ruse to convince their coworkers that Mike is a real lawyer....
Watch Suits Season 1 Episode 1 on Rainierland
Next Episode...
Season: 1 Episode: 2
Diffuse: 2011-06-30
Mike has an ethical dilemma when Louis forces him to make a decision that could hurt his relationship with Harvey. Elsewhere, Harvey's past comes back...Watch Next Episode


text: This Is What A Mercedes G-Wagen Should Really Be AboutAndrew P Collins8/15/14 9:37amFiled to: G-WagenMercedes-BenzHooningAwesome Picture3915EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Earlier this week I told you how disappointed I was with the 2014 Mercedes G63 AMG; an awkward product of a work truck peer-pressured into acting like a sports car. But make no mistake; the Mercedes G-Class is a star when the chrome handcuffs come off. Image: Mercedes-BenzReply39 repliesLeave a reply