text:
Yersinia pestis is a Category A pathogen and the causative agent of pneumonic plague. A type III secretion system (T3SS) that is essential for virulence is used by Y. pestis to export a set of proteins known as Yops. Yop effectors (e.g. YopE) are delivered into host cells to disrupt intracellular signaling pathways. Yop effectors are delivered across the host cell plasma membrane by the translocators YopD and YopB. The LcrV protein, localized to the tip of the T3SS, is required to insert YopD and YopB into the plasma membrane and is a well-characterized protective antigen. Y. pestis also assembles protein fibers on its surface that are composed of the F1 protein. F1 is a protective antigen and is being developed together with LcrV as a subunit vaccine. Murine IgG MAbs specific for LcrV or F1 have been shown to confer passive protection against plague in mice. However, it is possible to genetically modify Y. pestis to make it resistant to LcrVand F1-based vaccines or immunotherapeutics, because F1- mutants remain fully virulent, and protective epitopes within LcrV can be altered. Therefore, additional protective antigens need to be identified and developed into targets for vaccines or immunotherapeutics to counteract the threat of genetically modified Y. pestis. This research will identify and characterize protective IgG MAbs specific for YopD and YopB that could be used to passively immunize humans against genetically modified plague.
In Aim 1, we will demonstrate passive protection of mice against F1- Y. pestis with MAbs specific for Yop translocator proteins. These experiments will establish a proof-of-principle that pneumonic plague caused by genetically modified Y. pestis can be prevented by MAb immunotherapy.
In Aim 2, we will identify epitopes in Yop translocators proteins recognized by protective MAbs. These studies will provide information on the nature of the protective epitopes, and allow for development of a MAb cocktail as an optimized immunotherapy.
In Aim 3, we will determine role of constant heavy (CH) regions in protective MAb function. F(ab')2 fragments of protective anti-YopB and anti-YopD MAbs will be generated and tested for protective activity. Chimeric (ch) MAbs containing variable regions of protective MAbs and human CH regions of different isotypes will be constructed, characterized for affinity and specificity, and assayed for protective function. Mice expressing human Fc receptor will be used to measure protective activity of murine-human ch MAbs. Results will increase the usefulness of these MAbs as immunotherapeutics in humans, as well as provide knowledge on the role of constant region in MAb function.
Plague is a highly virulent disease in humans and is considered a major threat as a biological weapon. Current strategies to prevent pneumonic plague, such as the use of vaccines or antibiotics, are non-effective or could be bypassed by intentional genetic manipulation of the pathogen. The studies proposed here will lead to the development of new immunotherapeutics to prevent or treat plague caused by genetically modified Y. pestis in the human population.
|Johnson, Joshua C; Martinez, Osvaldo; Honko, Anna N et al. (2014) Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells. Antiviral Res 107:102-9
|Gough, Daniel J; Marié, Isabelle J; Lobry, Camille et al. (2014) STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood 124:2252-61
|Kazakov, Teymur; Kuznedelov, Konstantin; Semenova, Ekaterina et al. (2014) The RimL transacetylase provides resistance to translation inhibitor microcin C. J Bacteriol 196:3377-85
|Rajsbaum, Ricardo; Garcia-Sastre, Adolfo; Versteeg, Gijs A (2014) TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol 426:1265-84
|Lo, Michael K; Bird, Brian H; Chattopadhyay, Anasuya et al. (2014) Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters. Antiviral Res 101:26-9
|Mackow, Erich R; Dalrymple, Nadine A; Cimica, Velasco et al. (2014) Hantavirus interferon regulation and virulence determinants. Virus Res 187:65-71
|Varshney, Avanish K; Wang, Xiaobo; Aguilar, Jorge L et al. (2014) Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice. MBio 5:e01007-14
|Chung, Lawton K; Philip, Naomi H; Schmidt, Valentina A et al. (2014) IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM. MBio 5:e01402-14
|DiLillo, David J; Tan, Gene S; Palese, Peter et al. (2014) Broadly neutralizing hemagglutinin stalk-specific antibodies require Fc?R interactions for protection against influenza virus in vivo. Nat Med 20:143-51
|Szaba, Frank M; Kummer, Lawrence W; Duso, Debra K et al. (2014) TNF? and IFN? but not perforin are critical for CD8 T cell-mediated protection against pulmonary Yersinia pestis infection. PLoS Pathog 10:e1004142
Showing the most recent 10 out of 549 publications


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Play Gateway
|Home »
|Escape Games »
Gateway Walkthrough
i got through 6 rooms so far i far if anyone can get through 7 let me know.
room 1:
hit buttons 4 then 1 go through other door
room 2:
walk over seperate sections in carpet to match design over door-tip start form the inside
room 3:
look through telescope right room, left room, right room, left room, right room
password is 739339 -peepers backwards
room 4:
knock over first board walk to end of platform. you'll notice the colors of the floor boards and the doors have changed. change both doors to purple, go back through left door and come out through right door. knock over board and change both doors/floor boards to original color
room 5:
pick up all pearls put them on "tables" in this order: large, medium, huge, tiny, big, small
room 6:
pick up screw driveruse to unscrew metal plate next to outlet. pick up extension cord drag ex. cord to t.v. cord to connect. then drag the connected cord to outlet. watch tv. click buttons to view cameras.
the number for keypad is found by tracking orange robot through the house. keypad number is 954271
yeahhh.. uh. i got to level 6 and i cant figure out how to get past it!
Room 7:
Pay attention to how many times each light blinks. It corresponds to the number of times you need to change the color for that spot.
Room 7:
Bottom Right - 1 Blink - red
Bottom Middle - 3 Blinks - Purple
Bottom Left - 5 Blinks - Light Blue
Top Left - 2 Blinks - Green
Top Middle - 6 Blinks - Pink
Top Right - 4 Blinks - Yellow
i cant pass the bit were there is to walkway i dont know how to pass that bit.
omg, I completed it, wow
KEVIN all u do is knock over the 1st plank walk to the end of the middle bit and the two bits on the floor change coulor, keep going over both planks till both are purple and wal through the door you first entered in. if done right u should end out of the other door (right one)walk over the coulored planks till they match the floor coulor vut first knock the plank down on your way obv then walk through the door :D:)XD the ending sucked a bit though i thought that it would be something good like aliens come down or something stupid like that lol
yay!! i completed the game!! thx ppl 4 ur help (:
I compleated the game thanks to all your help, by the way, when you knock over the plank and walk across, the colors only have to be the same color, not just purple, well thanks
I have no idea what telescope you're talking about...there is none! PLease help.
im really stuk on room 5!
weneva i try 2 put da pearls on to da table it keeps on saying dat i am nt close enough!!
plz can u help me anyhow??
This is a really short, and rather pointless game. Once you finish the bit with the lights and get on the elevator, it's finished. I like Gateway 2 better.
what's the story behind this game, anyway? i don't get what this has to do with the story in Gateway 2. and what's the story behind Gateway 2? anyone know?
what's the story behind Gateway 1 and 2 anyway? i don't really get it. anyone know?
when you have to put the pearls in order, which order do they go in
THe story in gateway 2 is that the orange bot that you meet everytime you get a tape is trying to sort the stuff in the tapes out in her mind. I might be letting a bit off for the people who haven't beaten the game, but people seem to be wondering!
whats the number for the telephone code. i´m frustrated and i tried everything. do i have to use the picked up lighter and mirror?
i couldn't pas room 1. I have 3 carpets tht change colors every time I walk above it, i put it in the same patter that shows the door (red inside, yellow dmiddle, green outside) but the door doesn't open. what am i doing wrong?
hey guys i like how mikezaun layed out how you get threw lvl7 but same as sebastion said im frustrated too but i cant get passed it so ty for the walkthrough guys for gate way i just figured out the code for gateway 1 and yes its 954271
hey um.... im goin to the walkthough for gateway 2 i like these kinda games:::)))_(((
seriously i dont get the story 2 gateway. the first one.
can someone explain it?
dugas13 i got in room 7
i just completed it
yay i past it i passed it i passed it!
hey players if u are on room 6 and already looked at the tv, go to the door and press the keypad and do these numbers 954271. then go through the doorway
hey players if u looked at the tv already go to the door and press the keypad and do these numbers 954271. then go through the doorway
Gateway walkthrough:
Stage 1 & 2: self-explanatory/guided by game developer.
Stage 3: combine the batteries with the remote and drag it over the red light on the door.
Stage 4: Press the furthest right button, then press the furthest left button.
Stage 5: There is a rectangle tile on the floor and two rectangular rings around it. Walk into the center. Then walk to the middle ring. Walk back into the center and notice the color change. Continue walking back and forth until the center is pink, then do the same for the middle and outermost ring until the middle is yellow and the outermost is green.
Stage 6: go to the telescope and look into it. you see a gray robot sleeping at the right bottom corner. click on anywhere to exit, then look into the telescope again. if you look at the same corner now, the robot will be standing behind the window staring at you (I recommend you to toggle off the sound, it actually scared me... -.-) move your mouse away and then look back at the corner again. the robot is gone, but he left the word 'PEEPER' on the window. Look at the words backwards and type in the numbers into the keypad.
Stage 7: Push the walkway. go all the way to the right edge of the middle floor and notice the change of color on two of the tiles on the floor. Walk back and forth until those tiles are the same color, go back to the right door and walk through it. You will come out from the left door. go back to the middle to remove the colors on the tiles and go through the left door.
Stage 8: Collect all the pearls. Use the huge pearl on the third box; the large pearl on the first; the big pearl on the fifth; the medium pearl on the second; the small pearl on the sixth and the tiny pearl on the fourth.
Stage 9: Go to the TV and pick up the screwdriver on it (might need to hover around a bit with your mouse). use the screwdriver on the service patch. open the service patch and get the extension cord. Pick up the power cord and use it on the extension cord. Go to the power outlet and use the plug on it. Go watch the TV. Press on 9 and you'll see the driveway of a house. Press on 5, you see an orange robot walking. follow her by testing out on the channels. write them down in the order she appears. (if you can't follow her, you can exit the TV and watch it again, it always starts over starting with channel 5) Go back to the keypad and type in 9 first, then the sequence the orange robot appears in the TV. (which is........... 954271)
Stage 10: if you walk over certain patch of the floor, it changes color the the light bulb above it flashes. Notice the different number of times each bulb flashes. (I recommend you to take a piece of paper and write out the number of flashes of each light bulb in a hexagon. mine: (starting with the northernmost light bulb, clockwise) 6, 4, 1, 3, 5, 2. Now walk over a random tile and record the color each step changes into. mine: 1)red 2)green 3)purple 4)yellow 5)blue 6)pink. Now walk around going back and forth to make the tiles on the floor the color it is supposed to be. ie: the northernmost light bulb flashes 6 times, which means that tile should be the sixth color, which is pink. Another example: the upper right light bulb flashes 4 times, which means the tile should be the fourth color, which is yellow. So complete all the tiles and an elevator will appear in the heart of the room. COMPLETE!
im at room 7
i put the colors on the floor the way theyre supposed to be
now wat????
Here is the walkthrough for level seven it will help you out a lot. For this level you will have to focus on the lightbulbs hanging above the coloured sectors, how ever many times it blinks, is how many time you have to step on the tile to get the desired colour to finish the level so if it blinked 3 times you have to step on the tile 3 times, ok? Anyway ill cut to the chase here is the correct clours and how many times u have to step on um. (Starting from th tile closest to the door, going clockwise. Blinks 1 - Red. Blinks 3 - Purple. Blinks 5 - Blue. Blinks 2 - Green. Blinks 6 - Pink. Blinks 4 - Yellow. And there you have it, now an elevator should appear in the centre of the room, click on it and the character will walk on it and dissapear. Hope you enjoyed the game! Now you should try Gateway II get to it from miniclip.com and type in the search box "Gateway II". you can also get to it by typing in Gateway and at the bottom of the game screen there will be 2 little boxes one advertising Gateway l and another advertising Gateway II, just click on the Gateway II advertisment box and away you go, have fun!
thanxxxx i completed it............
the game is pointless
gateway2 is better
oom 1:
hit buttons 4 then 1 go through other door
room 2:
walk over seperate sections in carpet to match design over door-tip start form the inside
room 3:
look through telescope right room, left room, right room, left room, right room
password is 739339 -peepers backwards
room 4:
knock over first board walk to end of platform. you'll notice the colors of the floor boards and the doors have changed. change both doors to purple, go back through left door and come out through right door. knock over board and change both doors/floor boards to original color
room 5:
pick up all pearls put them on "tables" in this order: large, medium, huge, tiny, big, small
room 6:
pick up screw driveruse to unscrew metal plate next to outlet. pick up extension cord drag ex. cord to t.v. cord to connect. then drag the connected cord to outlet. watch tv. click buttons to view cameras.
the number for keypad is found by tracking orange robot through the house. keypad number is 954271
Room 7:
Bottom Right - 1 Blink - red
Bottom Middle - 3 Blinks - Purple
Bottom Left - 5 Blinks - Light Blue
Top Left - 2 Blinks - Green
Top Middle - 6 Blinks - Pink
Top Right - 4 Blinks - Yellow
The very first room u just click button then head on to the "Room 1"
On room 1, click 4th button, then 1st button
On room 2, Look at the right door, make those colors on the mat
on room 3, click the telescope and look at both rooms left and right until u see "peepers" Enter the code
on room 4, knock over the 1st board and make both of the boards on the center floor purple, then walk into the left door and knock down the right board then make the purple boards back to normal then enter right door
on room 5, pick up each pearl in order ( it doesnt have to be like that but its easier ) large medium huge tiny big small
Then place each one on each of the tables from 1-the last one in order: large medium huge tiny big small
on room 6, pick up screwdriver and unscrew the plate then pick up the cord and attach to Tv cord then watch Tv from rooms 9 to 5 to 4 to 2 to 7 to 1 954271
on room 7, start from the lower right light and make each of the floors the colors( Look at the above comment )
Then go on the elevator thing and yeah ..
oh yeah theres a message at the end it says
gateway 2 is alot better!
this one is 2 ez
I finished! Just read through the instructions and follow wat they say. its easy trust me. :) for the room with the boardsthis is wat u do.
1:push the first board down
2:walk till reach edge.(colors are on ground)
3:keep walking on them till they are both purple.
4:walk through first door.(You will come out the door to the right.
5:push down second board.
6:walk across to colors.
7:change colors to normal color.
8:click the button to open the door all the way to the right and walk through.
TADDA YOU HAVE DONE IT!!! keep on trying till you get it!
Great game
i'm on gateway II.
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Eshe is a Kiwi brand of decks and skater clothing.
Four of these posters are from 2010.
The bottom four were just released this week.
I'm only posting the old ones because of the recent Muhammad kerfuffle.
Posters were done in-house.
They appear to be heavily influenced by the Garbage Pail Kids cards.
I, for one, am outraged at the weak, hackneyed creativity.
"Scientolo G" looks a tad like Tom Cruise (not the "Maverick" bling).
Gandhi getting a hummer. This image, in particular, has upset a couple of commenters on Ads of the World.
Check out more articles on BuzzFeed.com!
- Donald Trump has named H.R. McMaster as his new national security adviser, replacing Michael Flynn who resigned last week.
- Famine in South Sudan has left 100,000 people facing starvation and nearly 8 million in need of immediate assistance, UN agencies say.
- Milo Yiannopoulos's book has been canceled after he was accused of defending pedophilia.
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- //Home
- //Music
- //Reviews
- //All That Remains
It took some time, but at last, the oversaturated American metalcore scene is now starting to separate the wheat from the chaff, as the lesser-talented pretenders are quickly giving way to their more creative peers. So insane has the trend become over the last couple years, that young bands are starting to copy other metalcore bands while completely ignorant of the genre's melodic death metal origins, and with every debut release, the cheap imitations of At the Gates, In Flames, and Morbid Angel have become more and more diluted. While some bands like As I Lay Dying have tried hard to bring a little accessibility to their music by employing melodic (or "clean") vocals, it's been the acts who have been the most audacious in their approach that have been able to successfully transcend what has come to be known as "kiddiecore" and "mallcore". Avenged Sevenfold's gonzo approach to combining epic power metal and pop punk choruses connected big time with younger audiences. Trivium brings songwriting flair to the sound, and has left the hardcore screaming behind for good. Shadows Fall continue their ascent up the American metal ladder. And in what has to be the most pleasant surprise of 2006, All That Remains has made the kind of stylistic leap that most bands can only wish they could pull off.
A product of the astonishingly talent-rich New England metalcore scene (along with the likes of Shadows Fall, Killswitch Engage, and Unearth), All That Remains turned in a semi-respectable effort with their second album, 2004's This Darkened Heart, which was highlighted by guitar duo Mike Martin and Oli Herbert, who in between faux-Pantera riffs and Hatebreed-style breakdowns, brought in slick dual harmonies that sounded indebted to Scandinavian metal, but smartly managed to sound genuine. For all his onstage charisma, though, lead screamer Philip Labonte merely delivered the same kind of melody-free lead vocals as every other band. He did show promise on "Tattered on My Sleeve", but aside from a few glimpses of originality, the album was little more than a drop in an overflowing bucket.
All That Remains
The Fall of Ideals
US: 11 Jul 2006
UK: 17 Jul 2006
With The Fall of Ideals, however, that all changes, and Labonte deserves much of the credit. A student of noted vocal coach Melissa Cross (who is quickly becoming one of the most influential behind-the-scenes figures in modern metal), Labonte has made an astonishing adjustment, bringing a wide array of vocal styles, the most impressive of which being a clean singing voice that soars over much of his band's competition. We hear it instantly on "This Calling", as his melodic chorus grabs us instantly, finding a comfortable middle ground between old school bombast and emo whinging, his assertive, commanding style setting Labonte apart from the usual screamers out there. The band is obviously aware of their newfound asset, and they put it to good use, especially on the first half of the album, as Labonte dominates such memorable tracks as "Not Alone", "It Dwells in Me", "We Stand", and "Whispers (I Hear Your)". So good is the first 20 minutes, that all five tracks all have the potential to go over huge with the Hot Topic set.
Labonte does take a back seat to his other four mates on "The Weak Willed", a monstrous slice of death metal, providing guttural accompaniment to the sinewy licks and taut picking of Martin and Herbert and the furious blastbeats of drummer Shannon Lucas. "Six" starts off with a hair-raising, Gothenburg-inspired intro before giving way to a stately breakdown that drips with melodic solos and E-bow harmonies, while the swaggering "The Air That I Breathe" beats Shadows fall at its own game, blending an old school gallop, aggressive mid-tempo verses, and melodic choruses like a band of seasoned pros.
Produced by Killswitch Engage's Adam Dutkiewicz, arguably the most ubiquitous producer in American metal today, the 39-minute The Fall of Ideals knows exactly how much is too much, the band coming in, tearing our collective faces off (hyperbolically speaking, of course), and leaving us wanting more. It's invigorating from start to finish, and could very well be the metalcore album of the year.
- Multiple songs MySpace
- "This Calling" MP3
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Tonsillitis medicine
Some of the top Manuka honey uses are wound care, allergy relief, skin problems, fight MRSA and prevent gingivitis and tooth decay. Visit: http://healthyfocus.org/8-great-manuka-honey-health-benefits/
Tonsillitis is a contagious infection with symptoms like sore throat, fever, pain when swallowing, headache, runny nose, hoarseness, and ear pain. It's usually caused by a viral infection or, less commonly, a bacterial infection. Although health experts normally recommend tonsil removal as the best treatment, this is not always true. Natural medicine offers a number of home remedies that can be extremely beneficial for successful treatment of tonsillitis. Aside from various natural…
Foods That Fight Viral & Bacterial Throat Infections
INSIDE THE SKULL, housed are these areas: anterior fossa, middle fossa, and posterior fossa. The posterior fossa contains the brainstem, cerebellum, and cranial nerves IV-XII. The posterior fossa (orange color) is formed by the occipital bone, which has a large hole (foramen magnum) for passage of the spinal cord.
The Hard Facts About Tonsil Stones #Infographic #Health
Tonsils are lymph nodes on either side of the back of the mouth, and their function is to protect against upper respiratory tract infections, if they become infected, they get inflamed and swollen with fluids and white blood cells, making swallowing painful and eating difficult.
Tonsils and Throat Reflexology Point... I dare you! This one reduces your sore throat! Sore Throats: My personal pet peeve of the Cold/Flu Season
Mucus build-up plagues people during a post-nasal drip, cold or flu, sinusitis, tonsillitis, strep throat, catarrh, laryngitis, chicken pox, measles, mononucleosis, whooping cough or croup. Allergies to certain food products can contribute to mucus build-up as well. When your system is weak from illness and allergies, these membranes can go into overdrive, causing that familiar stuffy feeling. In such circumstances, many medical practitioners recommend you avoid foods that cause mucus…
Here are some of the remedy resonance for Tonsillitis. Each of these remedies must be taken only when the totality of the symptom is indicated.
Cayenne Pepper as a Healer! Great for blood purifier, head ache reliever, and cancer-fighter!


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|Property type
|Minimum Stay
Stylish, immaculately converted barn on eco-friendly, sheep and cattle farm, in a secluded, peaceful location. Relax, unwind and enjoy our beautiful moorland landscape with superb wildlife. Perfect for walking, cycling, birdwatching and exploring the many attractions of the Peak District including Bakewell, Buxton, Chatsworth House and Alton Towers. Children very welcome.
Fernyford Barn is a luxury, fully equipped self-catering accommodation set on a working farm and run by our family. We did our best to make sure that our holiday cottage is a perfect blend of modern facilities and good old country comfort and cosiness. Fernyford Barn is a delightful property with stone floor downstairs and solid oak flooring on the first floor, exposed oak and stone lintels giving warmth and character. There is under-floor heating downstairs and in the bathroom. Recently gaining Four Stars and a Gold Award from Quality in Tourism, it has an open plan Living room with fire place, fully-equipped kitchen, double bedroom with 5ft bed and second bedroom with two single beds. The property has its own patio area to sit out and enjoy the peaceful location.
Fernyford Barn is ideal for couples and families. A warm welcome for babies and children.
Our self-catering cottage is the ideal accommodation for a relaxing country holiday - set in the glorious Peak District countryside. It offers a perfect balance between being able to completely unwind, or, if you prefer, getting involved with the day to day life of a working farm! We will be happy to offer our guests the opportunity to experience seeing the livestock on the farm, the different farming operations throughout the year and to taste quality meat produced on the holding.
We had a lovely stay in this fabulous barn on Big Fernyford Farm. There are footpaths almost from the front door and Neil and Dorita were very friendly. A very nice few days.
|No additional mandatory fees


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Women's March on Washington secures post-inauguration permit
WASHINGTON (AP) — Police in Washington said Thursday that they have issued a permit for the Women's March on Washington, a demonstration planned for the day after the inauguration of President-elect Donald Trump.
Holistic security plan for women on cards
The ministry of skill development and entrepreneurship will create special programmes while the hea...
ET Women Ahead: Corporate India's fastest rising women leaders
The stars of ET Woman Ahead say believe in yourself, leverage your strengths, ...
If Punjab is secure, the nation is secure: Amit Shah
Amit Shah was addressing an election rally here in support of BJP candidates for the Punjab Assembly elections.
Sharad Yadav insults women, again
"Your god is dark like (Union minister) Ravi Shankar Prasad (present in the House), but your matrimonial ads insist on white-skinned brides," he said.
Objectification of women makes you aggressive!
Higher levels of objectification of women were significant predictors of aggression towards them, psychologists claim.
Amazon to 'nurture' women entrepreneurs in Nagaland
The programme also aims to encourage cottage industries in Nagaland by helping them grow through online commerce.
#LeanIn: Kalpana Morparia feels women can make offices friendlier for other women
The banker also thinks that it's time to go easy on men & their expectations.
Alpine Skiing-World Cup women's standings
ALPINE SKIING-WOMEN/STANDINGS:Alpine Skiing-World Cup women's standings
PM providing security to 'friend' Nita, nothing for women in Delhi: CM
Officials said Nita has recently been provided a 'Y' category cover. About ten armed men would be travelling with her.
Alpine Skiing-World Cup women's standings
ALPINE SKIING-WOMEN/STANDINGS:Alpine Skiing-World Cup women's standings
Women are swiping right for adventure junkies on Tinder!
The globetrotter bunch is the next popular lot with women on Tinder.
National Policy for Women focused on empowering women: Maneka Gandhi
Gender sensitisation and non-discrimination in the portrayal of women has been envisaged to ensure that women are not represented in a demeaning or stereotypical manner, Maneka Gandhi.
Figure Skating-Four Continents championships women's results
FIGURE SKATING-WOMEN/GANGNEUNG-RESULTS:Figure Skating-Four Continents championships women's results
Alpine Skiing-World championship women's slalom results
ALPINE SKIING-WOMEN/ST. MORITZ-RESULTS:Alpine Skiing-World championship women's slalom results


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Team gb women's swimming
Explore related topics
Adidas Official Team GB London Olympics 2012 womens swimming costume 40": Amazon.co.uk: Sports & Outdoors
Team GB Women's Swimming, Olympic Games, London 1908 On display at the British Library, Olympex 2012 exhibition. www.bl.uk/olympex2012
I NEED to have this to wear on days we have swim meets for my Special Olympics athletes who do the medley! This would help them out sooooo much!
Hannah Miley secured her second Team GB Olympic berth with victory in the women's 200m individual medley final at the British Swimming Championships.
#RIO2016 Jack Laugher and Chris Mears of Britain pose for a picture as the Team GB diving team is announced for the Rio 2016 Olympic Games at the John Charles...
Day thirteen: Keri-Anne Payne of Team GB competes in the Women's Marathon 10km Swimming at Hyde Park.
Diving: Team GB Women's Diving
The nine women who will make up the Team GB synchronised swimming squad and compete at the London Olympics were named in Aldershot by the British Olympic Association on Tuesday.
The Duchess of Cambridge and team GB ambassador Robin Cousins watch the Women's Teams Synchronised Swimming Technical Routine on Day 13 of the London 2012 Olympic Games © Adam Pretty/Getty Images
British #swimming team gb #speedo women's swimwear #costume size 30 new, View more on the LINK: http://www.zeppy.io/product/gb/2/182233246921/


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Creating Colorado
The Making of a Western American Landscape, 1860-1940
By (author) William Wyckoff
Format: Paperback
Normal Price: $78.00
Your Price: $70.20 AUD, inc. GST
Shipping: $7.95 per order
You Save: $7.80! (10% off normal price)
Plus...earn $3.51 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
Creating Colorado by William Wyckoff
Book DescriptionSprawling Piedmont cities, ghost towns on the plains, earth-toned placitas set against the Sangre de Cristo Mountains, mining camps transformed into ski resorts-these are some of the diverse regions in Colorado explored in this fascinating book. Historical geographer William Wyckoff traces the evolution of the state during its formative years from 1860 to 1940, chronicling its changing cultural landscapes, social communities, and connections to a larger America and showing that Colorado has exemplified the unfolding of a complex western environment. Wyckoff discusses how nature, capitalism, a growing federal political presence, and national cultural influences came together to produce a new human geography in Colorado. He explains the ways in which the state's distinctive settlement geographies each took on a special character that persists to the present. He leads the reader through the transformation of the state from wilderness to a distinct region capable of accommodating the diverse needs of ranchers, miners, merchants, farmers, and city dwellers. And he describes how a state created out of cartographic necessity has been given uniqueness and meaning by the people who live there.
Buy Creating Colorado book by William Wyckoff from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780300071184
(229mm x 152mm x 19mm)
Pages: 352
Imprint: Yale University Press
Publisher: Yale University Press
Publish Date: 8-Feb-1999
Country of Publication: United States
Books By Author William Wyckoff
How to Read the American West, Paperback (March 2014)» View all books by William Wyckoff
Offers a fresh perspective on the natural and human history of the American West and encourages readers to discover that history has shaped the places where people live, work, and visit. This book includes stories, photographs, maps, and diagrams on a hundred landscape features across the American West.
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pustulenoun [ C ]uk /ˈpʌs.tʃuːl/ us /ˈpʌs.tʃuːl/ specialized
Thesaurus: synonyms and related words
(Definition of "pustule" from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press)
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Word of the Day
to move along by putting one foot in front of the other, allowing each foot to touch the ground before lifting the next


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100% Cotton Imported Machine wash cold with like colors, dry low heat PricePlow Supplement / Fitness / Nutrition Brand T-Shirt Lightweight, Classic fit, Double-needle sleeve and bottom hem
Front: PricePlow Skull LogoBack: NEVER PAY RETAIL AGAINShirt type: 100% Cotton Anvil Relaxed Fit Machine wash cold with like colors, dry low heat Lightweight, Classic fit, Double-needle sleeve and ...
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PowerPoint 2007 is popular presentation software. You can use PowerPoint 2007 to combine text, graphics and backgrounds to create slideshows for display on a computer screen or for projection onto a wall screen for audience viewing. You can also print out PowerPoint slides as audience handouts. PowerPoint 2007 has built-in features you can use to modify how text appears in your presentation. You can use the font features to create numerical superscripts.
Open the PowerPoint 2007 document in which you want to type a number as a superscript. Position your cursor in the document in the place where the number should appear.
Display PowerPoint's "Font dialog Box" by clicking the small arrow in the lower-right corner of the "Font" section of the ribbon at the top of your screen.
Click the "Superscript" check box to type subsequent text in superscript format.
Uncheck the "Superscript" checkbox to return to regularly formatted text.
Alternatively, highlight text already typed and click the "Superscript" box to change the highlighted section to superscript format.
Tips & Warnings
- You can use features in the "Font Dialog Box" to adjust superscript parameters. For example, adjust the "Offset" to increase or decrease the amount to which the superscript is raised above the baseline.
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leave your review
Buckle BurnsvilleStore's name : Burnsville Center
Address & Contacts
Phone number
(952) 898-1495
(952) 898-1495
2309 W Burnsville Pkwy
Ste 1094
55337 Burnsville
2309 W Burnsville Pkwy
Ste 1094
55337 Burnsville
Opening Times
|10:00am - 9:00pm
|10:00am - 9:00pm
|10:00am - 9:00pm
|10:00am - 9:00pm
|10:00am - 9:00pm
|10:00am - 9:00pm
|11:00am - 6:00pm
Edit opening hours
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Buckle Burnsville is usually open Sunday.
These times do not include public holidays. To see if your store is open these days, contact them.
- Clothing
- Buckle in Minneapolis 203 E Broadway
- Buckle in Minneapolis 2655 Southdale Ctr
- Buckle in Eden Prairie 8251 Flying Cloud Dr Ste 2012
- Aéropostale in Burnsville (1.86 km)
- Zumiez in Minneapolis (2.15 km)
- Maurices in Burnsville (2.37 km)
GPS position
- Latitude : 44.7548
- Longitude : -93.30959
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I'm on 100mg this cycle and I can't say that my pimples have been any worse than normal. I have really sore one on the tip of my nose at the moment with no head though It hurts like nothing else.
I'm on 100mg this cycle and I can't say that my pimples have been any worse than normal. I have really sore one on the tip of my nose at the moment with no head though It hurts like nothing else.
FP I really hope that is a real positive OPK!
Now I am at CD1 I think I will start charting my temps. I'm so excited!!
Also, I know this is jumping ahead, but if I conceive this cycle (if I behave like a normal person this cycle!) then my due date will be within a week of my bday
When I was on 100mg, I got small, hard pimples all around my hairline but nowhere else. Weird, huh?
AFM, I'm on day three of my 37.5 iu injections, and last night was worse than the first night, but still pretty easy. My first blood test is on Thursday. Hoping for some movement with my numbers
woohoo sounds like lots of you have falling pregnant thats great news
well im on my last chance of clomid, if this fails im no longer beable to see my gyno i'll have to go to ivf ....
how are you all going???
i havent been on for a while...
Hi Zammy, would you consider FSH + IUI before IVF? (if Clomid is not working for you) it's a lot cheaper than IVF, less invasive and may be what u need (without knowing your history of course).
Clomid did nothing for me, and I've been told it just won't work for some people, I could not grow any follies at all on Clomid. But the FSH injections is definitely helping me grow follies, then the HCG trigger makes me ovulate, would never have happened without drugs!
Got my cross hairs on FF today and I am 3DPO. Yay!!!! My first ever 2WW. I've been trying for a year but I've never been in the 2WW.
Nice wok, FP!
AFM, I'm going in for a blood test tomorrow to see how the Puregon is working. Fingers crossed!
familyplanner961 (10-11-2011)
Congratulations FP! and welcome to the TWW, sending you heaps of positive vibes, babydust & patience
God I need some patience. I've already got imaginary symptoms like heightened sense of smell and tender breasts. I have to keep telling myself that they're not real cos I'm only 4DPO. The madness of the 2WW has already set in!!
My chart is looking nice and dandy though http://www.fertilityfriend.com/home/35e332
Haha, me too! I've had a persistent headache since yesterday, similar to what I got last time when I got my bfp, plus DH commented on my b00bs feeling strangely 'squishy', he said this last time too! FX!! can't test for another 7days though.
Your chart is looking great! Good luck!
familyplanner961 (11-11-2011)
Pregnant for the first-time?
Not sure where to start? We can help!
Our Insider Programs for pregnancy first-timers will lead you step-by-step through the 14 Pregnancy Must Dos!


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Sold out.
Shades of lime, lemon and orange were hand spun from a beautifu, soft art batt made by Butterfly Girl with merino, bamboo and angelina fibers. Then the yarn was crinkle plied with slightly sparkly mohair and silk thread creating this soft and etherial art yarn with lots of character!
Fiber Content: Merino, Bamboo, Angelina, Silk, Mohair
Yardage: 170 yards
Gauge: Averages 9wpi/Worsted but please keep in mind this yarn changes with the spun character
Spun by: Ronda Van Dyk
Note: Every effort has been made to portray fiber/yarn colors accurately.


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In a study conducted by researchers at Vanderbilt Center for Bone Biology, it has been found that stress can promote spread of breast cancer to the bone.
The study was published in PLoS Biology and demonstrated the "fight-or-flight" response to stress in mice. The way sympathetic nervous system responds to stress fuels bone structure for breast cancer cell metastasis. The researchers used propranolol, a cardiovascular medicine, to prevent lesions caused by breast cancer.
Florent Elefteriou, director of the Vanderbilt Center for Bone Biology, said that the main goal of the study is to prevent the metastasis of breast cancer, which kills more women than does a primary breast tumour.
Elefteriou and his co-researchers were aware from the findings of their previous studies that sympathetic nervous system triggers bone remodelling and uses similar signals that have been implicated in the spread of breast cancer to bone.
To find the possible link between sympathetic activation and increased risk of breast cancer metastasis to the bone, the researchers carried cancer cell metastasis in mice. Human breast cancer cells were injected into the mouse's heart to develop a model of the stage of metastasis when breast cancer cells shift from the primary site and move as per the direction.
Read more Health News
Understand Depression - Identifying your stress triggers is an important step to deal with stress.read more
Scientists have found the particular gene that was responsible for anchoring and triggering cancer cells to move from one organ to another, in this case, the lungs.read more


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The Mosaic Company (NYSE:MOS) [Trend Analysis] try to make new thrust in street and making different trends, stocks trading ended with -2.90% to $27.41. Finally to see some strong financial remarks by WSJ over MOS performance. Out of the pool of analysts 2 gave their BUY ratings on the stock in previous month as 4 analysts having BUY in current month. The stock was ranked as Underweight by 2 analysts while 5 analysts gave SELL rank. Majority ranked Hold from the pool of analysts.
The next year first quarter EPS estimates trend for current period shows $0.15 while one month ago this estimate trend was for $0.18. EPS indicator shows the robustness of the stock and its analysis opens up the clear picture of company's profitability. On annual basis of EPS, FY 2017 Estimate Trends at current were for $0.97 and for the one month was for $1.02 as compared to three months ago was for $1.09. Whereas, MOS received highest price target of 33 and low target of 19. The stock price target chart showed average price target of 24.85 as compared to current price of 27.41.
The share price of MOS attracts active investors, as stock price of week volatility recorded 5%. The stock is going forward to its 52-week low with 28.33% and lagging behind from its 52-week high price with -13.54%.
Parsley Energy, Inc. (NYSE:PE) [Trend Analysis] attempts to attain leading position in street, Shares price changes as it -4.10% to close at $33.72 with the total traded volume of 3.38 Million shares. Finally, analysts shed their light over the PE price targets; maintaining price high target of 51 while at average the price target was 42.61 in contrast with the current price of 33.72. The price targets are usually acts as the boosters or blasters in the performance of stock. A higher price target would definitely provide confidence to investors during the trading action, consideration given by Wall Street Journal.
So does the rankings given by analysts; let us highlight rankings table and we had 27 analysts recommending BUY ratings for current month and for previous month 29 stands on similar situation; while 4 for the current month as compared to 3 analysts recommending for HOLD from the pool for previous month. While 1 stands at overweight. For the overall, consensus ratings were for Buy.
The firm has institutional ownership of 88.80%, while insider ownership included 8.40%. Its price to sales ratio ended at 19.11. PE attains analyst recommendation of 1.80 with week performance of 1.66%.


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I will create a HD spokesmodel or product demo video(13)
About This Gig
Frequently Asked Questions
I have a custom project, can I order a video that is not a package?Yes! You can send us a note with some details about what you need and we can reply or talk and then we can provide you a custom quote. We often do custom work!
What information should I send to receive an accurate quote?Do you have a script and what is the word count? Do you have a product to demo? What background, wardrobe, model do you want? Extra images, graphics, text, b-roll or logo? How quickly you need the project completed?
Can you help me with a script and/or storyboard?Yes, we can help with both! We charge $60/hour with most basic scripts taking about 1 hour to understand key points then refine it. If you need a complex storyboard that can take usually 2-3 hours which includes graphics with a script. We ALWAYS get your approval prior to filming.


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Search Results for:
Brazel, Cabrera Bello tied for Rd 3 lead in Hong Kong
Sam Brazel and Rafa Cabrera Bello share the lead heading into the final round at the UBS Hong Kong Open.
Cabrera Bello nears career high in OWGR
A runner-up finish at the UBS Hong Kong Open propelled Rafael Cabrera Bello to nearly unprecedented heights in the latest world rankings.
Golfing World: Wood eyes Ryder Cup debut
BMW PGA Championship winner Chris Wood looks ahead to making his Ryder Cup debut at Hazeltine.
European Tour players do Mannequin Challenge in Dubai
Watch as European Tour players do the Mannequin Challenge at the DP World Tour Championship in Dubai.
Golfing World Slice: 'A Bug's Life' for Cabrera Bello and Scott
The latest GW Slice features a couple of big winners in Vegas from the Shriners Hospitals for Children Open, and Rafael Cabrera Bello and Adam Scott taking on an unenviable eating challenge.
On the Clock: Player to watch at Ryder Cup
Will Gray and Ryan Lavner debate who is the player to watch at the Ryder Cup this week.
Who could be the breakout star at Ryder Cup?
The Golf Central panel predicts what players could become stars at this year's Ryder Cup.
Golfing World: Cabrera-Bello's journey to better golf
Spanish European Tour star Rafael Cabrera-Bello, who has a good chance of qualifying to play in his first Ryder Cup in 2016, speaks to Golfing World about the improvements he's made across the board in his game that are starting to truly pay dividends.
Golfing World, Ace of Clubs: Rafa Cabrera-Bello
Spanish European Tour star Rafael Cabrera-Bello picks his driver as his Ace of Clubs, the club in his bag that holds a special place in his heart.
Cabrera-Bello: My career has been a steady progression
Rafael Cabrera-Bello reflects on the steady progression of his career ahead of the 2016 BMW PGA Championship.


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Which Joe gave his name to 'sloppy joes'? We look at five interesting sandwiches and their lexical origins.
Definition of spireme in English:
(also spirem)
The tangled strands of chromosomal material seen in the early stages of cell division, formerly believed to be a single continuous strand (or two in a diploid cell, etc.)
- 'The spiremes of the two nuclei become coarser and intermingle before any distinct chromosomes are visible.'
- 'Methanospirilla cells appear regular, curved and finally form spiremes.'
From German spirem, from Greek 'coil', 'convolution'.
Further reading
6 punctuation marks you might be using incorrectlyRead more
We take a look at several popular, though confusing, punctuation marks.
An A-Z of country name originsRead more
From Afghanistan to Zimbabwe, discover surprising and intriguing language facts from around the globe.
How brothers became buddies and brosRead more
The definitions of 'buddy' and 'bro' in the OED have recently been revised. We explore their history and increase in popularity.


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More information: http://www.myspace.com/thecongregationchicago
The Congregation plays a righteous combination of blues, soul and rock & roll. They do it the old-fashioned way, the way Otis Redding, Ike and Tina Turner, Howlin' Wolf, Aretha Franklin and Bo Diddley did it– real instruments, raw and powerful vocals, down and dirty soul. This female-fronted powerhouse will take you from "aw, shucks" to "Goddamn!", before you know what slapped you in the face. When it comes to the songwriting, you won't find any sugarcoated love songs here, you'll get a little bit of longing and a whole lot of wronging. The Congregation's recently released debut EP, 'Not for Sleepin', showcases their signature style of bluesy garage soul.
Artist descriptions on Last.fm are editable by everyone. Feel free to contribute!
All user-contributed text on this page is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply.


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A diverse whisky region, the proximity to the sea often proffers slightly salty, sometimes smoky whiskies. Balance is a recurring theme; sweetness and pungency in perfect harmony. A decidedly eclectic assortment of whiskies is to be found on the Islands. It is hard to categorise them, indeed the fact they are a category of their own is most probably for geographic ease rather than for discerning between styles. There is often, however, a marked salinity, particularly in whiskies from Isle of Jura, with their oily nature and gentle peat.
The Isle of Skye is beaten by the elements, the sole distillery, Talisker, uses a peated malt and the smoky, pungent drams it produces are quite similar in style to the punchy whiskies from Islay's southern coast.
Mull is slightly more unfamiliar, its sole distillery, Tobermory produces soft whisky with menthol freshness and plenty of sweetness. Orkney is a dark, weathered isle, there is often a salty character, but, certainly in Highland Park's case, there is sublime balance. Arran is a newcomer to the scene, and its sole distillery and namesake is producing whiskies that have recently come of age. There is plenty of barley sweetness, no peat and a good fruity character.
It's the Arran distillery's seventh batch of their Machrie Moor peated single malt Scotch whisky, named after a mystical peat bog on the west coast of Arran. Their seventh batch was released in the… More info
Elixirs are said to give life to those who need it, if fantasy fiction is to be believed. While we don't think this Isle of Jura 12 Year Old Elixir has any magical properties (in fact, we're sure of… More info
A superb 18 year old from the Highland Park distillery and a winner of a Gold Medal at the 2005 San Francisco World Spirits Competition. More info
We've bottled another deliciously smoky heavily peated single malt from the Isle of Mull's Tobermory distillery! This was distilled on the 17th September 1997 and left to age in a Sherry butt until… More info
Single malt from the Highland Park distillery, bottled by Gordon & MacPhail for their MacPhail's Collection. It was distilled back in 1989 and bottled in 2016 at 43% ABV. More info
The Isle Of Jura Turas-Mara was originally launched for the Travel Retail market, and is comprised of malts which have matured in a selection of different casks, including bourbon barrels, wine casks… More info
A 10 year old from the Tobermory distillery on Mull, a Gold Medal winner at the 2008 International Wine and Spirits Competition. More info
A gentle, affable 10 year old single malt from the Tobermory distillery on the Isle of Mull. Now at the higher strength of 46.3%... More info
Well-peated single malt from the Tobermory distillery, released under the Ledaig name and independently bottled by That Boutique-y Whisky Company. This was aged for 18 years before being bottled, and… More info
A cask strength bottling from the Talisker distillery, bearing no age statement. This was named for the Isle of Skye sits on the line of latitude 57 Degrees North. More info
19 year old single cask single malt from the Arran distillery, located on the eponymous Scottish island. This was distilled in September 1996 (the year after they started distilling) and aged in a… More info
Officially launched in 2006, this 10 year old lies at the heart of the Isle of Arran range and exudes all the honeyed richness we have come to associate with the island distillery. More info
American oak cask matured Scapa single malt Scotch whisky finished in casks that previously held smoky, peated whisky! Scapa describe Glansa as a gentle introduction to the world of peated whisky. More info
Ahh, Ledaig! A cracking single malt that proves Islay isn't the only place to get your hands on splendidly peaty whisky - the Tobermory distillers on the Isle of Mull also know their way around… More info
After spending 30 years maturing, this Highland Park single malt Scotch whisky has earned the right to be enjoy very slowly, to have every sip savoured. Bottled at a slightly lower abv than previous… More info
A classic Island dram from the Isle of Skye. Always highly rated, this was an Editor's Choice at Whisky Magazine. Lots of spice and fresh, tangy peat. More info
A single malt from the Isle of Arran distillery, celebrating the famed Scottish poet, Robert Burns. This tasty bottling is officially endorsed by the World Burns Federation, making it perfect for… More info
Oh hello there! This is the fifth batch of Arran single malt Scotch whisky bottled by That Boutique-y Whisky Company - originally for the fantastic whisky weekend which is Dramboree (hence some of… More info
Following on from Highland Park Ice Edition and their Valhalla Collection is the Highland Park Fire Edition! This 15 year old single malt was matured in refill Port casks before being bottled at… More info
An 42 year old single malt Scotch whisky from Tobermory! An extraordinarily well-aged whisky from the distillery on the Isle of Mull, which even contains some of the first spirit produced when the… More info
The Charity Auction has now ended.
This is a very special one-of-a-kind bottle of Scapa Jutland, a 16 year old single cask single malt, which has been named after HMS Indefatigable. The Scapa… More info
A rare Talisker single malt whisky bottled in 2011 for Diageo staff at natural cask strength.
This bottle was part of a private collection - if you'd like more detailed info and/or photos just get… More info
Duncan Taylor bottled this 14 year old Jura at a full 54% abv in October 2012. More info
A rare release from the Highland Park Vintage Collection. This 1978 vintage single malt Scotch whisky from the island of Orkney was originally launched as a travel retail exclusive. More info
This was launched in April 2010 for the Travel Retail market, and is a full litre bottling of 1998 vintage Highland Park. Lots of fruit and manuka honey, and aged for 12 years in American bourbon oak. More info


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After the patient's anemia was corrected with blood transfusions, he continued to have a slow drop in his hemoglobin level and there was concern of continued bleeding into this retroperitoneal space. Therefore, he was taken to the operating room to determine the origin of the mass and undergo resection. In the operating room, the mass was well encapsulated and noninvasive (Figure 2). It was circumferentially dissected and found to originate from the inferior pole of the kidney. A right radical nephrectomy was performed and pathology examination revealed the mass to be undifferentiated renal cell carcinoma with tubular and papillary features. In this particular case, the patient was bleeding into the tumor and the tumor was filled with a large hematoma.
During surgery, the large mass was found to be well encapsulated and noninvasive and originating from the inferior pole of the left kidney.
The differential diagnosis for a retroperitoneal mass can include sarcoma, lymphoma, adrenocortical tumors, neurogenic tumors, hematoma, or an abscess. Lipomas and their malignant counterpart, liposarcomas, are the most common primary retroperitoneal soft tissue masses.1
Renal cell carcinoma is increasing in incidence with almost 55 000 new cases and an estimated 13 000 deaths in 2008.2 The classic clinical presentation consists of flank pain, hematuria, and an abdominal mass. However, this triad occurs in only 5% to 10% of cases. Symptoms may be nonspecific and can commonly include anorexia, lethargy, weight loss, or fever. Rare but dangerous presentations include tumor thrombus into the renal vein or inferior vena cava, hepatic dysfunction (Stauffer syndrome), and paraneoplastic syndromes from tumors secreting erythropoietin, parathyroid-like hormone, renin, or cortisol.3 Recently, there was a report of renal cell carcinoma presenting as hemorrhagic shock due to retroperitoneal bleeding from the mass.4 In this case, there was constant bleeding at a slower rate, resulting in transfusion requirements and anemia but not shock.
Renal cell carcinomas are histologically categorized as clear cell, papillary, chromophobe, collecting duct, or not otherwise specified, with clear cell being the most common. Patients with papillary or chromophobe subtypes have a better prognosis than patients with the clear cell subtype.5 In the United States, the most widely used grading schema is the Fuhrman nuclear grade, which has been shown to correlate with tumor stage and long-term survival for clear cell renal cell carcinoma.6
The only potentially curative therapy for localized renal cell carcinomas is surgical resection. Percutaneous biopsy of the mass before resection is generally not necessary since it will not affect therapy. Select circumstances when a preoperative biopsy may be useful are when an abscess or another primary tumor, such as lymphoma, is suspected. Partial nephrectomy is equally efficacious as total nephrectomy and may be performed if the tumor is less than 4 cm and is peripherally located, or when there is renal insufficiency, a solitary kidney, or bilateral renal tumors. Surgical resection can still be done if there is contiguous organ invasion, which is usually to the liver, diaphragm, psoas muscles, pancreas, and bowel. Postoperative disease surveillance includes abdominal computed tomography and chest radiography. Chest computed tomography, bone scanning, and brain magnetic resonance imaging are reserved if there is clinical suspicion of metastatic disease.3 The 5-year survival rate for patients with renal cell carcinoma is more than 70% for those with organ-confined disease and approximately 55% and 17% for those with regional and metastatic disease, respectively.6 For metastatic disease, systemic therapy consists of immunotherapy, such as interleukin 2 or interferon alfa, or newer targeted agents such as sunitinib malate, sorafenib tosylate, temsirolimus, and bevacizumab.3,7
Return to Quiz Case.
Correspondence: Barish H. Edil, MD, Department of Surgery, Johns Hopkins University, 1550 Orleans St, Cancer Research Building II, Room 508, Baltimore, MD 21231 (firstname.lastname@example.com).
Accepted for Publication: June 18, 2010.
Author Contributions:Study concept and design: Edil. Acquisition of data: Edil. Analysis and interpretation of data: Nguyen and Edil. Drafting of the manuscript: Nguyen. Critical revision of the manuscript for important intellectual content: Nguyen and Edil. Administrative, technical, and material support: Nguyen and Edil. Study supervision: Edil.
Financial Disclosure: None reported.
Image of the Month—Diagnosis. Arch Surg. 2010;145(7):704. doi:10.1001/archsurg.2010.121-b
© 2017


text:
let's stand far apart.
- Posted Sept. 18, 2009 by Hailey. Viewed 1565 times
- This is a migrated legacy post. Image resolution is low. Info
i think they loved eachother that day.
3 There are 3 comments, add yours!
2009.09.21 Edited
ha ha, love it!
2009.09.21 Edited
haha cool pic ^^
2009.09.21 Edited
so serious...lol...people are so funny.


text:
All hotels in London, England, United Kingdom
1 room, 2 adults
153 Earlham Grove, Forest Gate, London, England, E7 9AP, United Kingdom, 020 3684 4822
Grove Guest House, London
Victorian B&B with restaurant, near Boleyn Ground Stadium
- Free breakfast, free WiFi and free parking
Main amenities
- 2 smoke-free guestrooms
- Restaurant
- 24-hour front desk
- Garden
- Self-serve laundry
- Luggage storage
- Tour/ticket assistance
- TV in a common area
Feel at home
- Garden
- Laundry facilities
- Iron/ironing board
- Hair dryer
- Coffee/tea maker
What's around
- In Newham
- Boleyn Ground Stadium (1.7 mi / 2.7 km)
- Olympic Stadium (2.2 mi / 3.6 km)
- Walkie Talkie (5.4 mi / 8.7 km)
- Tower of London (5.6 mi / 9.1 km)
- O2 Arena (5.7 mi / 9.1 km)
See all 51 Hotels.com reviews
Great room
Great location
Tasty breakfast
Fantastic service
TripAdvisor Traveller Rating: 5
From 121 reviews
Grove Guest House, London
Hotel Info: 020 3684 4824from £46
- Double Room, 1 Double Bed with Sofa bed, Shared Bathroom
- Double Room, 1 Double Bed with Sofa bed, Ensuite
More great choices
At a glance
Key facts
Hotel size
- This hotel has 2 rooms
- Check-in time starts at 2 PM
- Check-out time is 10 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
Other information
- Smoke-free property
Nearby Two Star London hotels
In the hotel
Food and drink
- Free breakfast
- Restaurant
- 24-hour front desk
- Tours/ticket assistance
- Laundry facilities
- Luggage storage
- Garden
- Television in common areas
In the room
Home comforts
- Coffee/tea maker
- Iron/ironing board
Freshen up
- Hair dryer
Be entertained
Stay connected
- Desk
- Free WiFi
Top London hotels
Recently reviewed hotels in London
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"Close to Earls Court Underground Clean rooms,a bit small.Staff very pleasant.Don't bother paying for breakfast."Feb 25, 2017
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"It was a very good hotel clean tidy staff were friendly room was excellent comfy bed i would recommend to family and friends "Feb 25, 2017
Also popular with travellers from the UK
Recent reviews
Outstanding 4.8 /5 from 51 reviews
Grove Guest House, London
Friendly, comfortable and handy guest house
This is a lovely guest house and an ideal place for a short break or to stay when working in London. The owner is really friendly and could not have been more helpful to me. The house itself is quite something, included many decorative features from the 1950s and 60s which you rarely see nowadays. The room I stayed in was clean, very comfortable and quiet. The breakfast was lovely as well and it was so refreshing to have a fried breakfast which wasn't swimming in oil!
Grove Guest House, London
Welcoming and comfortable hotel
Service was excellent. Very friendly owner who made me feel at home. Breakfast was cooked to order and hotel even sent a menu the night before to choose from. Very tasty. breakfast. Quiet room with a very comfortable bed. Will hopefully return
Grove Guest House, London
Home from home
I thoroughly enjoyed my stay at this guest house. It won't be for everyone, due to the informal and bohemian nature of the building and hospitality, but I found it a real home from home. The owner was very welcoming and couldn't do enough for me. The breakfast was superb and it was a nice change to have the company of the landlady at the breakfast table. It was more like staying over at a friends house and definitely a better ambience than staying in some of the more sterile chain hotels I usually frequent. There is a great pub across from the train station that serves good and reasonably priced food, as well as proper ales on draught. There are plenty of takeaways and mini supermarkets around too if you need them. I would definitely recommend this place and will be returning when I am next in the area.
Grove Guest House, London
Charming Victorian guest house
A lovely Victorian house full of nik naks and full of character. Very quite and safe at night with good pub and places to eat very close by.
Grove Guest House, London
Welcoming and homely guest house
A friendly and welcoming guest house with good facilities.
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text: CitiCar, The Most Produced Electric Car In U.S. HistoryMatt Hardigree1/07/08 4:30pmFiled to: RetroAlternative EnergyCitiCarCommutaCarGrounded For LifeSebring-VangaurdElectric Car18EditPromoteShare to KinjaToggle Conversation toolsGo to permalink With word of more alternative fuel cars coming out (like the possibly electric Cadillac Provoq), we thought it was time to visit the most successful electric car in our country's history. Approximately 2,200 Citicars (a.k.a. CommutaCars) were built by a company based out of Florida. The two-seaters were powered by a 3.5 horsepower motor connected to eight 6-volt golf-cart batteries. The result was a wedge-shapped oddity capable of approximately 30 mph and a range of 40 miles in optimal conditions. The car is somewhat famous for being the car that Uncle Eddie pilots on the sitcom Grounded For Life (including a scene where he tries to escape it in but his brother grabs the pillar and slows it down by hand). Versions of this car that didn't end up in a scrap pile are now very minor collectibles and can even be found on eBay. We'll take one in yellow, thank you very much. [Econogics]Reply18 repliesLeave a reply


text:
Data Deluge
Researchers Turn to Cloud Computing as Genomic Sequencing Data Threatens to Overwhelm Traditional IT Systems
Seeking Young Scientists for Research in Space
Sounds of Science Podcasts
Infectious Fight
Tackling the Inevitability of Resistance One Genome at a Time
Long Noncoding RNAs: Clarity or Confusion?
Because They Are Such Elusive Prey, lncRNAs Have Yet to Emerge as Therapeutic Targets
Regenerative Sciences Grants NeoStem Exclusive Asia License to Regenexx
NeoStem obtained an exclusive royalty-bearing license for Asia to use Regenerative Sciences process that rapidly grows a patient's own adult stem cells to treat a variety of musculoskeletal diseases. NeoStem will use the Regenexx technology to develop treatments for chronic orthopedic conditions.
NeoStem provides adult stem cell collection and banking to the general population and recently acquired licenses to use stem cells to treat chronic wounds and for cosmetic facial rejuvenation. "The minimally invasive Regenexx procedure complements NeoStem's established in-office stem cell collection procedures and expands our expertise into a new area," says Robin Smith, M.D. and CEO of NeoStem, "Restoring joints, bone, muscle, and cartilage and combating orthopedic diseases complements our growth in the anti-aging and regenerative medicine arena."
Regenerative's founder and CEO, Christopher Centeno, M.D., will serve as a consultant to NeoStem in the area of stem cell therapy in orthopedics and will train NeoStem personnel in mesenchymal stem cell isolation, preparation, and transplantation methods.
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Absolute Local Services
Pipe Inspection, Locating Services
Absolute Locating Services understands the importance of locating pipes and cables prior to undertaking construction activities, in order to prevent any risks to workers, the community and the environment. Our dedicated team of Utility Locators and advanced equipment will provide you with the locations of underground services to ensure the safety and integrity of your site.
We are experienced with locating pipes and lines such as gas, telecommunication, electrical, water, sewer and storm water, fuel and fibre optic lines.
Print this page
Absolute Locating Services provides fast, effective and reliable pipe freezing services to all water-based industry trades. This method provides minimum
Ground penetrating radar (GPR) is a geophysical method that uses radar pulses to develop an image of the subsurface stratigraphy.
Hydro excavation, Ground penetrating radar, Leak Detection, concrete survey, locating pipes and cables, pipe freezing services
Hydro excavation is a non-destructive digging method that uses high pressure water to loosen soil, which is then removed by
Using state-of-the-art equipment Absolute Locating Services is able to establish the precise location of where leakages are occurring. We do
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text:
This Is The Real Reason Why Huddah Monroe Wants To Get Pregnant As Soon As Possible
After denying she wasn't pregnant about a year ago, claiming she didn't say she was expectant and that the media misquoted her. Reason being, she didn't want to be called a 'socialite'. She told people to stop calling her that because she could be a mom. She actually got defensive about it and in the process implied that people are stupid, yes! That includes you and me. I know some of you are curious like me, so i can't help but ask, who is Huddah Monroe? That's if she still claims she is not a socialite.
But now it's 2015, and Huddah the scandalous Kenyan socialite or whoever she is, now agrees with herself that she likes the idea of having kids. Well, this comes after her message to Zari Hassan, her Tanzanian counterpart who is currently pregnant with Diamond Plutinumz kid. She was congratulating her on the latter. In the tweet, Huddah adds she wishes she was the one which seemed more direct that she wants to be pregnant. Oh! Huddah, the whole world can't wait.
As it stands, it seems she will never stop amazing her fans. But will she deny it this time round? I wish i had the answer to that but my guess is we will be surprised really soon.
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Every time a user or search engine spider visits a Web page, the server that page resides on returns a code. These codes show whether the page loaded correctly, was moved, or if there's a problem. Understanding these Web server responses to user and search engine requests is a critical aspect of SEO and Web site usability. Relay the wrong response, and you could create a world of hurt for your Web site in the search engines, or have some dissatisfied users on your hands.
Basic Server Response Codes
There are many different response codes, many that you will most likely never have to worry about. But there are a few that will keep coming up, which have the potential to make your life easier or more difficult. Here are the definitions of the basic server response codes.
200 — OK. The request has succeeded. The vast majority of all requests should generally end with this response. In layman's terms, this means the request was understood, accepted, and the page you requested will appear.
301 — Moved Permanently. The requested resource has been assigned a new permanent URL and any future references to this resource should use one of the returned URLs. Clients with link editing capabilities ought to change the existing URL to the new URL if it happens to rank for a given keyword. If the URL doesn't rank, and if the URL structure has many dynamic parameters, it may be wise to rewrite the URLs (using either ISAPI rewrite or Mod_Rewrite) to include keywords within the URL string.
When undertaking any rewrites of URLs, you should use 301 redirects to ensure that the SEO value of the existing URL is passed along to the new URL. In summation, this means the document has permanently moved to a new location, and search engines should reference the new location.
302 — Found. The requested resource resides temporarily under a different URL. Since the redirection might be altered on occasion, the client should continue to use the old URL for future requests. This way, the search engines cache the old URL and not the new one. This keeps any rankings the page may have until you decide where you might want to permanently redirect this page. This is commonly referred to as "temporarily redirected," which means the document has moved to this location for a while. Search engines don't forget about the old location.
404 — Not Found. The server has not found anything matching the request URL. No indication is given indicating whether the condition is temporary or permanent. The 410 (gone) status code should be used if the server knows that an old resource is permanently unavailable and has no forwarding address. This status code is commonly used when the server doesn't wish to reveal exactly why the request has been refused, or when no other response is applicable. See the common pitfalls below on how the misuse of these redirects can impact SEO efforts.
For more information and definitions on server response, check out the status code definitions on the W3.orgsite.
Common Pitfalls
Below are some of the common pitfalls in using server response codes, as this relates to search engine optimization:
- Using 302 temporary redirects when the change is permanent. When you've changed the URL of a document and have no plans to change it back, you should use a 301. Using a 301 redirect will help you pass along any value/rankings that the legacy URL had. That being said, some search engines do better than others in following the 301 redirect. If your experience is anything like ours, you will find that Google does a fine job of associating the two, though Yahoo will take a while to fully value change.
- Custom 404 pages resolving to a 200 OK server response. When a page can't be found on some content management systems, it should provide a custom 404 page letting the user know that the page no longer exists and pointing out main sections of the site. While this is great for the user experience, serving these pages incorrectly can cause a bunch of these "page not found" pages to be indexed in the search engines. By ensuring that these pages are properly referenced as 404s, you can properly redirect the visitor to a relevant page and ensure that there are not any issues of "duplicate content" (pages for which the only text on the site says "page not found").
- Sometimes, the search engines aren't as good as advertised in following redirects. MSN Live has indexed 301 redirects as blank pages, and examples of 302 hijacking seem to make a comeback every now and then. We have witnessed very quick responses to 301s from Google and are still hoping to fully recover from some 301 redirects with Yahoo after several months. MSN is hit or miss, depending on what they're doing in any given month. Bottom line: do 301 redirects when you have to and consult with an SEO professional if you believe there could be any chance that you could lose rankings as a result of any URL changes.
- Canonical issues. Your first response to this may be, what the heck is a canonical issue? Here's the thing. You should reference your site — in particular your home page — in one way. You'll notice that if you try www.searchenginewatch.com, it redirects to http://searchenginewatch.com/. You'll also notice that our site resolves to www.vizioninteractive.com even if you try http://vizioninteractive.com. Many sites link to their home page internally as, www.example.com/index.html. Each instance of a site resolving to a given URL is a different address, as far as search engines are concerned. To get the inside scoop on canonical issues, you should read Matt Cutt's blog.
Knowing the basics of server response codes and when to use them correctly is critical for any competitive Webmaster or search marketer. You can check your own server responses with many online resources including this status code checker. If you have any questions regarding redirects and content management system setup, contact a search marketing professional.
Mark Jackson is off this week. Today's column ran earlier on Search Engine Watch.
Related reading
Five most interesting search news stories of the week
This week, we've got the latest on a strange glitch appearing in Google's mobile search, a new beta search engine launched by Creative Commons, and the decline of brand hashtags in Super Bowl ads.
What's been going on with Google's mobile indexing?
Back in October, Google announced the impending rollout of a mobile-first search index which has had SEOs scrambling to prepare their businesses. Some strange behaviour over the past few days indicates that we may be approaching a launch.
What were Google's biggest search algorithm updates of 2016?
While we're still piecing together lessons from last year's wins and losses, here is a visual and entertaining summary of Google's moves in 2016 that might well help us in predicting where SEO will take us in 2017.
Six steps to a stronger online brand
When it comes to maintaining a brand, any good marketer will tell you that reputation management is key. But it's not just about monitoring what others say about your business; it's also making sure you know how to prevent reputation crisis by building a stronger brand.


text:
Interfaith Alliance urges publishers to ignore Texas teaching standards
- March 21, 2010
- By Bob Allen
Faith-based panel recommendations leave some issues unsolved
- March 9, 2010
- By Adelle M. Banks, Religion News Service
A White House advisory council March 9 submitted 164 pages of recommendations on ways the federal government can partner better with faith-based groups in tackling a host of social problems, from poverty to improving interfaith relations.
Obama, Clinton at prayer breakfast denounce Ugandan anti-gay proposal
- February 3, 2010
- By Robert Marus
Study finds abstinence-only programs effective in delaying sex
- February 2, 2010
- By Bob Allen
One American in eight needs food assistance, study shows
- February 1, 2010
- By Ken Camp, Managing Editor
Common ground on abortion not impossible, but tough to find
- January 26, 2010
- By Adelle M. Banks, Religion News Service
Faith âkeeps me calm,â Obama tells church
- January 17, 2010
- By Adelle M. Banks, Religion News Service
New statement âfirst-ever consensusâ on religious expression and the law
- January 11, 2010
- By Bob Allen and Robert Marus
Study says larger churches hit harder by economy
- January 10, 2010
- By Bob Allen
Scholar says faith-based initiative failed to increase churches' role
- January 7, 2010
- By Bob Allen
Report says use of death penalty on decline in United States
- January 6, 2010
- By Bob Allen
In 2010 predictions, Pat Robertson says America under God's wrath
- January 4, 2010
- By Bob Allen
Religious broadcaster Pat Robertson said God's wrath is looming over a nation headed for economic ruin in his annual predictions for the coming year Jan. 4 on "The 700 Club."
Evangelical leaders support abortion compromise in health-care plan
- December 17, 2009
- By Bob Allen
Supreme Court to deal with rights of religious groups at state schools
- December 6, 2009
- By Robert Marus
No more imprecatory prayers; now Drake wants treason trial for Obama
- November 19, 2009
- By Bob Allen
More Articles...


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text: If you purchased an MP3 player with the sole purpose of downloading sermons, or If you were shocked to just discover that some people download MP3 files that are not sermons, or If you have adjusted the default passage setting at www.biblegateway.org from "NIV" to "ESV" … you might be a Calvinist. If your preacher says to turn to Obadiah and you do not use the index, or If you think a 50-minute sermon is too short, or If you've ever heard a wave of groans sweep through Sunday School when you refer to Romans 9, …you just might be a Calvinist. See the whole list at..Tominthebox After reading the link....Please add you own to this thread.


text:
What To Expect From Ubiquitous Ultrabooks In 2012?
Striking Features:
So what is that grabs your attention to the core? These notebook computers are built to deliver best in class performance standards, built in security features with higher responsive rate, light in weight, and sleek designs. They offer better computing standards and define a new standard in the mode of delivery of services to the end users. The processors are faster and better. They are equipped with better RAM, larger screen size and better storage medium. The complete system is designed to be highly batter efficient which will utilize low voltage processors. It uses a technology called "Rapid Start" which will make use of the flash storage embedded in the motherboard of the system to speed up the booting process.
Why Should You Have One?
The sleek and swanky design will grab your attention and you will be a proud owner of an ultrabook computer.
The convenient design makes it very appealing. They can be transported very easily as they are light in weight.
It has a better computing process rate which sets new standards in the world of computing.
Though the features offered are so high class in terms of service, the laptops are still sold under the price tag of $1000. This proves to be an economical and viable solution for students and working professionals.
Additional Features And Super Specialty Functions:
They are powered by Windows operating system. They offer the extra functionalities of the tablets such as stay connected to Wi-Fi mediums, solid state drives, instant activation, longer battery life etc. The future ultrabooks are expected to be touch sensitive and people need not wait for a longer period of time to exercise these functionalities.
In-Built Security Systems:
The Ultrabook laptops come with firmware application that will employ the features of Intel's Anti-Theft Technology and Identity Protection Technology. These systems are run on the Intel's third generation core processors which are superior and are expected to deliver greater performance. The "Haswell" processors are designed to give better battery efficiency and faster graphics processing system.
Thin, light weight Ultrabooks are going to be the future of laptops. This will certainly revolutionalize and change the behavior pattern of a normal laptop user. Are you geared up to have your own Ultrabook computer now? If so, what are you waiting for?
This is an article by Rajkumar Jonnala who has been researching a lot about desk cable management and cable tidy & found the above portrayed information to be valuable. He believes that sharing knowledge in the internet domain will help in spreading information. If you wish to write for us, kindly check out the guidelines to write a guest post.