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Amtrak is a convenient way of shuttling up and down the northeast corridor, with downtown to downtown service. While most trains offer a Business Class service, you should know that not all Amtrak business class services are the same.
Interestingly, Amtrak runs 3 types of Business Class services in the Northeast Corridor:
- Amtrak Acela Express Business Class
- Amtrak's Northeast Regional 2×2 Business Class
- Amtrak's Amfleet Dinette 2×1 Business Class
In this specific post, I'll be covering what's considered the best Amtrak seating layout: The Amfleet Dinette.
While the Acela Business Class and Northeast Regional Business class do have a bit of extra legroom, the Amulet Dinette is Amtrak's little secret – and offered a totally different type of seat.
The Amfleet Dinette is only found on certain train numbers, and the concept is simple: Half of the Cafe car is used as Cafe seating, the other half is 2×1 Business Class seating.
Here, you'll see the one half – Cafe car seating for use by the entire train.
On the other half, you'll find Business Class.
Notice that these seats are in a 2×1 layout, halve more legroom, and also have footrests. In addition, the seats recline way more than the average seat, and an included leg rest pops out, nearly mimicking a angled flat business class seat on a major airline.
Included with your ticket is complimentary non-alcoholic beverages (which are steps away thanks to this seating being in the Cafe car) and newspaper. Sure, it's not like an airline service, but for Amtrak, it's the best of what's there.
You won't find these on every Amtrak train, and certainly won't find them on the pricier Acela Express.
What trains offer this deluxe business class?
- 54/55-56/57 – the Vermonter, serving Washington DC to St. Albans, VT and intermediate stations
- 66/67 – the overnight Northeast Regional, serving Newport News, VA to Boston, MA and intermediate stations
- 42/43/44 – the Pennsylvanian, serving Pittsburgh, PA to New York, NY and intermediate stations
- 89/90 – the Palmetto, serving Savannah, GA to New York, NY and intermediate stations
Find those elusive Awards & Upgrades - Find Flight Availability, Flight Upgrades & Awards, Frequent Flyer Information and more with ExpertFlyer.com
Looking for the best way to earn miles and points quickly? Visit the "Credit Cards" drop down on the main menu bar above for the hottest deals! Want to learn more and stay up to date on the latest tips, tricks and deals? Join My Travel Tips Facebook Page! This site is part of an affiliate sales network and receives compensation for sending traffic to partner sites, such as CreditCards.com. This compensation may impact how and where links appear on this site. This site does not include all financial companies or all available financial offers. Opinions expressed here are author's alone, not those of any bank, credit card issuer, hotel, airline, or other entity. This content has not been reviewed, approved or otherwise endorsed by any of the entities included within the post.


text:
- Details
- Specs
- Reviews
DETAILSThe foundation of K2's binding progression, The 2011-2012 K2 Formula snowboard binding is loaded once again with canted footbeds, Pro-Fusion GF chassis lightness and Rocklock highback coring. Now with 4 colorway's, one's sure to fit your kit.
- Short Description
- Key Technologies: Profusion GF; Rocklock Highback; Canted Footbeds
- Construction Features:Chassis: Pro-Fusion GFHighBack: RockLockAnkle Strap: Custom CaddiStrap Features: Hinge Mount & NEW Cam-Lock CenteringToe Strap:EZ-SetRatchet NEW Mega RADchet, EZ-FeedDiscs: Mulit-Compatible & Offset discsFootbed: Canted Seamless EVA
- k2b-formula-bind-p
- Brand Name
- Style Name
- No

subset: commoncrawl


text:
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Hello everybody :)
It's my first post here and i want to have your opinion about a headphone i intend to purchase...
It's a wireless one, and here are the specifications:
Impedance: 32Ω.
Sensitivity: 108dB.
Frequency Response: 20Hz-20.000Hz.
Driver Unit: 40MM.
Supports: Bluetooth, Micro SD Cards.
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Compatible with all devices
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Wish you the best :)


text:
By Will Weissert, Associated Press Writer
HAVANA The Vatican's No. 2 official expressed the Roman Catholic Church's concern about prisoners in Cuba during a Tuesday meeting with President Raul Castro, but stopped short of asking the communist government to free inmates.
Raul Castro's meeting with Cardinal Tarcisio Bertone was the new Cuban president's first with a visiting dignitary since taking over from his 81-year-old brother Fidel two days ago. Bertone is Pope Benedict XVI's secretary of state.
Wrapping up a six-day visit to the communist-run island, the cardinal said the relationship between the Church and Cuba's government "will always be challenging, but also full of opportunities to promote the well-being of Cubans."
He said that during the closed-door meeting, with the "utmost respect for the sovereignty of the country and its citizens, I expressed to President Raul Castro the Church's worries for prisoners and their families."
Bertone's visit marked the 10th anniversary of Pope John Paul II's visit to Cuba and its timing, just after Fidel Castro announced his resignation, was a coincidence. Following the late pontiff's trip in 1998, Cuban authorities released a large number of inmates, including 99 held for political crimes.
Bertone touched on the theme of prisoners before the meeting with Cuba's prisoners.
Earlier, the cardional told the news agency of the Italian Bishops Conference, SIR, that in discussions with Cuban officials he had not asked "directly" for the release of political prisoners.
"It would look like interference," he was quoted as saying. "The Church does not impose, but proposes."
He also told the agency that the island's leaders had assured him they would allow some Roman Catholic broadcasts on state-controlled media.
"Authorities have promised me more openness in the print press and the radio -- and in some exceptional cases, in television as well," he said. "We do hope for some openness, because nothing is impossible."
Bertone has called for improving often-strained relations between Cuba's government and the Church, and reacted warmly to official invitations for Benedict to visit the island.
Besides requests that some Catholic services be aired on official media outlets, Church officials have long urged the government to ease bans on religious schools. But Bertone told SIR that he "did not ask for Catholic schools, but for greater space in formation and education."
During his visit, Bertone has also called the U.S. embargo against Cuba "ethically unacceptable."
Addressing reporters moments before he left Cuba, Bertone said that he assured Raul Castro of "the Holy See's promise to promote bringing the world closer to Cuba."
Cuba's single-party, communist government never outlawed religion, but expelled priests and closed religious schools upon Fidel Castro's takeover of Cuba in 1959. Tensions eased in the early 1990s when the government removed references to atheism in the constitution and let believers of all faiths join the Communist Party. They warmed more with John Paul's visit.
But in a message to Cuban bishops last week, Benedict said some Catholics on the island are frustrated by difficulties, mistrust and a lack of resources.
Since arriving in Cuba, Bertone has presided over large Mass services in Havana and Santiago, as well as in Guantanamo, which borders the U.S. naval base.
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Man flips Camry after driving up power pole in Orange
ORANGE – A 20-year-old Santa Ana man was arrested on suspicion of driving under the influence after the Toyota Camry he was driving flipped over Thursday morning.
The driver suffered minor injuries, but refused medical attention, police Lt. Fred Lopez said.
The man, who was not identified by police, was traveling northbound on Townley Street, turned eastbound on Garden Grove Boulevard, near The City Drive, his car mounted the curb and continued up a retention wire used to stabilize a power pole, Lopez said. That's when the vehicle flipped.
The incident occurred on the eastbound side of Garden Grove Boulevard near The City Drive around 8:40 a.m.
Contact the writer: 714-796-7802 or email@example.com
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text:
As we slog
into the last 10 days
of 2010
(schoolwise, anyway),
I'm put in mind
of Disney
and that
"wind up"
We're wound up,
strung out,
parsed over
and full, up to HERE
holiday cheer.
I'm going
on auto-pilot
until December 22.
It's a small world,
after all.
If you'd like to participate in Mrs. Scribe's Poetry Slam, there's no fuss, no muss. You won't see Mr. Linky, but we'd greatly appreciate if you linked up to this post. The more, the merrier, correctamundo?


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Jeff Locke (2-2, 5.28 ERA) and Jose Urena (0-0, 9.00 ERA) start in the second of a three-game series between the Pittsburgh Pirates (22-22) and the Miami Marlins (18-28) at PNC Park. The Pirates won the last game 4-2 and Pittsburgh leads the series 1-0. Action begins at 7:05 p.m. ET on Tuesday, May. 26 and can be seen on FSN-FL and ROOT-PIT.
Locke is 1-2 with a 3.62 ERA in his appearances against the Marlins, and goes up against a quality Miami offense which is batting .260 this season. Starling Marte (.284, 22 Rs, 9 HRs, 30 RBIs, 7 SBs) continued his strong play yesterday, going 2 for 4. Urena went 2.0 innings, surrendering three runs in a 5-4 defeat to the Mets in his last outing. Giancarlo Stanton (.234, 27 Rs, 13 HRs, 42 RBIs, 3 SBs) has been successful at the plate, going 2 for 4 yesterday with one run, one home run, and two RBIs.
Pittsburgh is a -150 favorite against Miami and the Over/Under (O/U) for this game is sitting at eight runs. The Pirates have an overall money line of -460 and a record as the favorite of 17-13. Pittsburgh's batters do not strike out very often at home, with only 6.5 per game. As for the pitchers, opposing offenses have been stifled by the Pirates, who have a team ERA of only 3.13. Opponents have consistently been struck out by the Pirates, who rank fifth in the NL in strikeouts per home game with 8.8.
In games where it is the underdog, Miami has a 8-11 record and an overall money line of -1,122. Offensively, the Marlins have really sputtered in the last 10 games. They have decreased their season average of 3.8 runs per game by averaging 2.8 during that stretch. When it comes to issuing walks, the Marlins have the fifth-fewest in the NL with an average of just 2.9 walks allowed per game.
The Pirates have the edge in the season series, 1-0. Locke (LHP) will be on the hill against the Marlins, who have a 5-2 record against left-handed starting pitchers.
Predictions: SU Winner - PIT, O/U - Over
Miami has won 37% (7-12) of its games when leading after 7 innings. However, Pittsburgh has won 41% (7-10) of its games when taking a late lead.
The Pirates are coming into this game after allowing zero walks during their last outing. The Marlins have a 2-4 record when opponents give up that many walks.
When they are outhit, the Marlins are 3-17. The Pirates have a 4-13 record when opponents outhit them.
Miami ranks near the bottom of the league at 27th when it comes to home runs, hitting 29 this season. Pittsburgh ranks in the bottom half at 20th with 38.
Ranking eighth, Pittsburgh is in the top 10 of the league in hits, notching 8.44 per game. Miami ranks in the top five at fifth with 8.87.
Pittsburgh and Miami both rank near the bottom of the league for their on-base plus slugging percentage. Pittsburgh sits at 24th with an OPS of .686 and Miami ranks 25th with an OPS of .678.
When the Marlins allow at least one home run, they are 8-15, well-matched with the Pirates who are 7-14 when allowing at least one homer.


text:
Everything you need to know for this chapter!!
- Created by: carrot1234
- Created on: 09-10-13 20:07
First 385 words of the document:
People in Business 4
When to recruit new workers:
When the business expands as it has more customers.
When an existing worker leaves or is dismissed and needs to be replaced.
Advantages of recruiting full time workers:
Fewer staff in total will be needed as they work more hours per week.
Lower recruitment and training costs.
Easier to manage and control fewer staff.
Workers may feel more secure and motivated having a full time job and earning more money
than if they worked part time.
If a worker has two separate part time jobs they may have divided loyalties this should not
be a problem for full time workers.
Advantages of part time workers:
The number of customers may not justify a full time worker so a part time worker saves on
Two workers may be more flexible than one full time worker e.g. may be able to cover for
Part time workers can be asked to work just at busy times of the day or week. This could
lead to better customer service and a competitive advantage.
Some workers may prefer part time employment for example if they have children to look
Recruitment stages:
1. Job description they need to decide on what kind of work they want the employer to do.
2. Person specification need to decide on what kind of person there looking for.
3. Advertise the job vacancy job adverts need to include- job title what the job involves
pay hours where the job is - company name how to apply.
Personal recommendation workers recommended by other employees, family or friends of the
business owner, business colleagues
Good because their skill are known, loyalty and trust. Their also well known by people.
4. Shortlist candidates the owner then chooses the best few people to interview. This can be
decided by:
The strength of the personal recommendations.
The details given on the application form.
Past experience, skills and qualifications of the applicants- All of these would have
been detailed on each applicants CV which is a summary of an applicant's education
and jobs to date.
Other pages in this set
Page 2
Here's a taster:
Interviews asking the worker questions.
Advantages of external recruitment:
New ideas and skills may be brought into the business which internal applicants may not have.
The selection process will have many more applicants than when using internal recruitment so
the standard of applicant would be high.
It does not create another vacancy in the business which then has to be filled.
Internal promotion can cause jealousy amongst current workers who may have wanted the
job but were not offered it.…read more
Page 3
Here's a taster:
All businesses must ensure that they have the right insurance against injuries to employees.
Employees also have the right to things such as sick pay, maternity, or paternity leave, holiday's and
so on.
1. Advertise in a way that encourages applicants from all sectors of society.
2. Pay at least the minimum wage for certain age groups.
3. Offer a written contact stating the workers' rights and responsibilities.
4. Select the best person for the job without discriminating anyone.
5.…read more
No comments have yet been made


text:
Don't miss
- New leadership at Adelsheim Vineyard in OregonPosted 2 days ago
- vinAmité Cellars finds its way in British Columbia wine industryPosted 3 days ago
- Myles Anderson sells his share of Walla Walla VintnersPosted 4 days ago
- Ashley Trout to pour Walla Walla wines at pre-Oscar party in L.A.Posted 5 days ago
- Merlot remains force in Northwest wine industryPosted 6 days ago
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- Tax relief bill for small Washington wineries moves alongPosted 1 week ago
- Red Mountain turns more red and greenPosted 2 weeks ago
- WAWGG is now Washington Winegrowers AssociationPosted 2 weeks ago
- Okanagan Valley orchardists transition to stellar wines at C.C. JentschPosted 3 weeks ago
11 Northwest Pinot Noirs to taste today
By Andy Perdue on September 29, 2013
Ponzi Vineyards 2011 Pinot Noir, Willamette Valley, $35
Here's a shining example of how prevalent the certified sustainable movement is within the Oregon wine industry. Luisa Ponzi harvested four LIVE (Low Input Viticulture and Enology) estate sites — Abetina, Aurora, Avellana and Madrona — as well as 12 other vineyards, each certified. Her largest production wine carries aromas of raspberry, spiced plum, cherry pipe tobacco, violet and lime peel. It's loaded with flavors of dark cherry juice, black currant and cola, while mild tannins make it quite smooth through to the lengthy finish of president plum, pomegranate and saddle leather.
Rating: Excellent
Production: 7,840 cases
Alcohol: 13.3%


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Corporate Governance and Firm Performance: Theory and Evidence from Literature
Pallab Kumar Biswas
University of Otago
Md. Hamid Ullah Bhuiyan
University of Dhaka - Department of Accounting and Information Systems
August 25, 2008
This paper is an attempt to give a short description of the theoretical literature focusing on different conceptual models of corporate governance and empirical studies relating to whether good corporate governance leads to better firm performance. Majority of the literature has been found to focus on the relationship between shareholders, directors, and management. The findings of these empirical studies are mixed and as a result, it is often difficult for users to draw any firm conclusion on the relationship. On the other hand, studies undertaken considering the overall corporate governance mostly provide evidence of significant relationship between corporate governance and firm performance. However, whether better corporate governance causes higher firm performance is still remains a valid research question for reasons like ambiguity regarding the direction of causality.
Number of Pages in PDF File: 29
Keywords: Agency Theory, Board Structure, Corporate Governance
Date posted: August 27, 2008 ; Last revised: September 28, 2008
Suggested Citation


text:
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text:
Spacious, year-round home with northwoods charm. Immaculate and like new condition. Knotty pine interior, fieldstone wood burning fireplace, loft all newer log furnishings included. Partially finished basement. Very level lot with private boat landing. A wonderful package on an excellent fishing lake.
Features Residential
|Style: Chalet
|Lake Chain: 0
|Garage: 1 Car, Drive-Under, Heated
|Lake Name: Stateline Lake
|Year Built: 1995
|River Name:
|Basement Type: Daylight, Exterior Entrance, Full Basement, Laundry Hookups, Partially Finished, Roughed-in Bathroom, Sump Pump
|Water Frontage (feet): 377
|Fin SqFt Total: 2,400
|Lake Size-Acres: 211
|Lot Size: 71438
|Shoreline: Sand
|High School:
|Site Influence: Faces South, Faces West, Lake Front, Level, No Thru Road, Quiet Area, Wooded Area
|School District:
|Construction: Frame/Stick


text:
Küller küllere
David Bowie Ashes to Ashes
David Bowie transcends time and Ashes to Ashes exemplifies this great artistry. Inspiration
Le costume de Bowie sur le tournage du clip « Ashes to Ashes », 1980. Ashes to ashes, fun to funky... 13 Janvier 2016.
DAVID BOWIE - Ashes To Ashes (2000) Farewell Ziggy. I hope we didn`t annoy you too much while you were here with us. Thank you for your music and everything else.
Ashes to Ashes: DCI Gene Hunt flanked by his faithful sidekicks, Ray Carling and Chris Skelton, and drawn by the action and intrigue of the London Met. Gene's turned his attentions to taking on the "southern nancy" criminal scum. However, Gene did not expect to be thrown together with a sexy, intelligent DI Alex Drake.
One of Bowie's boyfriends, an older interpretive artist was Bowie's inspiration for this and much of his art.
★ David Bowie pour le tournage du clip de Ashes to Ashes en 1980. Un costume de Natasha Korniloff. Photo de Brian Duffy
One of my all-time favorite songs: David Bowie - Ashes To Ashes (Live) love the chat with the fans
Bowie from Ashes to Ashes....His body of work will forever make me happy. Saddened by his passing. 1/11/16
Bowie's Pierrot costume designed by his longtime friend Natasha Korniloff. Photo by Brian Duffy


text:
Is Ammex Isupport incorrect or missing key business information? Update your Hotfrog listing today.
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Is Ammex Isupport in 7/F Pearlbank Center 146 Valero St, Makati City your business? Claim your listing and attract more leads by adding more content, photos and other business details.
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Is Stulz Singapore incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Singapore provides information regarding Stulz Singapore in Singapore. Stulz Singapore is located at 33 Ubi Avenue 3 #03-38 Vertex, Singapore 408868 and provides Engineering services. Contact them on 6749 2738 or by visiting them on their website http://www.stulz.com.
Is Stulz Singapore in 33 Ubi Avenue 3 #03-38 Vertex, Singapore 408868 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
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Is Brave Canadian Petroleum incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Canada provides information regarding Brave Canadian Petroleum in Scarborough ON. Brave Canadian Petroleum is located at 4919 Steeles Ave E, Scarborough ON M1V 4Z4 and provides Automotive services. Contact them on (647) 827-6453.
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Computing Unit B-5 2370 Midland Ave Unit B-52370 Midland Ave SCARBOROUGH ONTARIO M1S 5C6
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I think this is no fault of the theater or the actors, but I just wasn't that impressed with this show. The music wasn't very good or engaging. I would still go back to this theater; the actors and musicians are very talented! This just wasn't...continued
Great fun, excellent set
Great staging, strong cast. I felt the script was a little weak. Still a fun night of innovative theater. Studio always delivers.
A fun, creative show....walking up the stairs to the performance space the audience was made to feel they were going to the Factory for a party.
A fun first half that floundered a bit later on. Probably could have dropped a few of the songs (there were 20-something) and explored a couple more ideas. It was pretty thin in this regard. And not in a meta sense, either, like a play about...continued
Some great acting and wacky things happening in the Factory!


text:
Quick Look
Property brokered by
Get more listing details on brokerage site
Presented By:
David Crawford
(515) 453-5409
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David Crawford
(515) 453-5409
Email Agent
Property DetailsNew modern ranch plan by Tanzanite Homes. The Coral features 3 bedrooms and 2 baths. Main floor has an open concept, family room with floor to ceiling stone fireplace, great kitchen with granite or quartz countertops, large pantry, white cabinets, and stainless steel appliances. Drop zone with lockers off the garage. Master suite with 3/4 bath and walk in closet. Other features include 3 car attached garage, passive radon system, all Tanzanite homes are built to Energy Star 3.0 standards. Home backs to creek, trees, and walking path. No closing costs or origination fee through preferred lender.
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Additional Property InformationThis single family listing located at 800 Nw 8th Street, Grimes, IA boasts three bedrooms, one bathroom and one partial bathroom. A ranch style property, it is currently selling for $299,900.
Additional features include basement.
This property is listed by David Crawford of Iowa Realty located in Iowa.


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Hotfrog SouthAfrica provides information regarding Impro Plumbing & Electrical in Cape Town Western Cape. Impro Plumbing & Electrical is located at 64 Gladstone St, Cape Town Western Cape 7530 and provides Home Improvement services. Contact them on 021 948 3198.
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Los Angeles Lakers Kobe Bryant 2013 Christmas Day Swingman Jersey
Join in on the Christmas Day action as you watch Kobe and the Lakers dominate the court with the 2013 Christmas Day BIG LOGO Swingman jersey from Adidas. It features high-quality graphics including a large Los Angeles logo on the front, Kobe Bryant's #24 on the left sleeve and back, and his name proudly displayed across the back.
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Copenhagen, Hovedstaden, Denmark
Welcome to our home in Elsinore, a 45 minute train ride north of Copenhagen/airport. Our charming two stories town house/apartment is located 5 minutes from...
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Beautiful 1920'ies home, completely restored by us in 2005. Contemporary Danish design based on the principle of aesthetic simplicity. Modern, yet cosy and comfortable. Equipped with everything you need for a great vacation.
Situated in a safe and friendly neighborhood, 15 minutes from downtown Copenhagen, and only 10 minutes from the beach. Access to car and 4 bikes (Copenhagen is a great place to bike), as well as extensive public transportation.
The house contains a nice living room with fireplace and TV and direct access to the garden, a modern kitchen in open connection with the dining room, an office, a master bedroom with separate bathroom, and two additional rooms sharing a bathroom. Lots of stuff to do for the kids: basketball hoop, fully equipped music room with electronic drums, guitars and keyboard, Playstation and games, wifi, etc. With direct access from the dining room, we have a large deck with tables and chairs and a barbeque. From the deck, there is direct access to the garden.
Copenhagen is a historic city - with roots that go back to pre-Viking days - and it is a gloriously royal city, too. Yet Copenhagen is also a distinctly modern city, known for its creative, innovative design and architecture, and its world-class cuisine (in fact, it boasts the most Michelin-star restaurants of any city in Scandinavia). The cultural scene offers everything from the world-renowned Royal Danish Ballet to sizzling jazz clubs and countless museums and galleries.
On Copenhagen's cobblestone pedestrian streets, visitors are greeted by funky boutiques, myriad cafés, major department stores and antique shops. Copenhagen is a lively, charming and safe city, and the Danes are known to be hip and friendly. People will speak English everywhere you go.
While you are here, go for a day trip to Sweden, or jump on the plane and get to any other European capital within an hour or two.
Check out our Wonderful city here:
Welcome to our home in Elsinore, a 45 minute train ride north of Copenhagen/airport. Our charming two stories town house/apartment is located 5 minutes from...
Our house is a 350 m2 classic villa from 1893 that has been delicately renovated to preserve its charming and romantic turn-of-the-century style with paned...
Our luxury Victorian villa is located on one Denmark's most attractive roads, next to Hellerup beach and harbor and only 5 km from Copenhagen city center....


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Dr. Frederick Brown MD Patient Reviews
- Family Medicine Missouri City, TX
Overall Rating
71 Patient Reviews
- Easy Appointments
- Friendly Staff
- Fair and Accurate Diagnosis
- Spends Time With Patients
- Appropriate Followup
- Wait Time 38.7 minutes
- Promptness
- Bedside Manner
Showing 1 - 12 reviews
5.0 of 5
October 19th, 2016
very positive friendly greeting
very happy with my experience
5.0 of 5
October 18th, 2016
It was a great experience.
It is always a great experience with Dr. Brown and staff. Everyone is polite and knowledgeable.
5.0 of 5
October 18th, 2016
I love Dr. Brown and his staff
Dr. Brown is very accomodating, takes time to talk through the plan of care with you and is very knowledable.
5.0 of 5
September 26th, 2016
Dr. Brown is saving my LIFE!
Dr. Brown has been so attentive,concerned about my particular issues but also my overall wellness. His staff reflects his professionalism, care and e ...
5.0 of 5
September 26th, 2016
very knowledgable, kind, and respectful
5.0 of 5
August 30th, 2016
Best Doctor
I greatly appreciate the level of expertise and concern for making the correct diagnosis and treatment.
4.0 of 5
August 30th, 2016
happy with Dr. Brown he's a good Dr and very personble.
been good
5.0 of 5
August 26th, 2016
Awesome Doctor and Staff
Very Very awesome experience. I was seen in a prompt manner and was able to get all my questions answered.
5.0 of 5
August 25th, 2016
Good office!
Generally good.
5.0 of 5
August 25th, 2016
great day with dr brown.
very informative visit today
5.0 of 5
August 25th, 2016
Great Doctor
The office and staff are wonderful. i have refer friends to Dr Brown
5.0 of 5
August 25th, 2016
Frederick Brown's review
Everyone is really friendly!! I like that Dr. Brown thinks outside the box. The staff really cares for everyone,
Health Guides
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text: Seller: watts251 (1,257) 100%, Location: Brighton, East Sussex, Ships to: Free Local Pickup, Item: 302134423681 Beautiful tapestry chairs - highly decorative and would look superb in a hall or with a period dining table. I am unable to determine exactly what period they are from - there are small wooden pegs used in the construction of the stretchers and there are signs of age (including a little defunct woodworm - which does not detract from the beauty of the chairs and I'm my opinion adds!). The could be thirties revival? If they are, then they have been made extremely well - nothing kitsch or mass produced looking about these and indeed when I came to photograph them I notice that the back of one is a smudge taller - the difference is where the moss green velvet parts attach the seats to the backs) The chairs are sturdy and the tapestry work is to a very high standard - looks to have been done by hand and is certainly not a woven tapestry effect fabric. The colours are vibrant (I have always been careful to keep them out of direct sunlight as the previous owners must have done) - again I cannot date the tapestry but presume that it is far more recent than the actual age of the chairs as I can tell from looking underneath that there are tell tale signs of previous upholstery having been attached. As I cannot age them I have listed them at a price which reflects their aesthetic and decorative appeal and have also taken a look at how expensive good quality modern reproductions are (various websites have them at about £700 each! And that is not with such lovely tapestry!) These chairs would look at home in an Elizabethan or any period property but could also suit themselves well to a more contemporary surrounding. Great chairs and only selling due to a lack of room to house and show them off properly. I have posted a selection of pictures, however, if you need any more pictures, have questions or would like to view the chairs then please don't hesitate to ask. I have listed them as collection only, however, if you wish to use a courier we can help load at this end and ensure that they are properly loaded on to his van - after that we could could not take any responsibility for the chairs in transit. *****I will be away on a short break from the 31st October but be back for collection or courier despatch from the 6th November***** Product Type: Dining Chairs


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First Viknar'off Showroom in Brody is Ready to Serve Customers
On August 19, the day when Christians celebrate the Transfiguration of Jesus, our partners from Brody opened the first in town Viknar'off showroom.
Traditionally, the opening ceremony was attended by the representatives of the factory - Nataliia Mostsitska, Supervisor Manager, Rostyslav Vatah, Head of Sales development, and Andriy Zhuk, Regional Manager.
A lot of kind words and wishes were addressed to the store owners who closely cooperate with Viknar'off factory. The warm and sunny weather contributed to the joyful atmosphere of the event.
The showroom is decorated in the company corporate style. It showcases window and door profile samples, decorative glass, window films, lamination designs, window sills etc. A wide range of product samples and experienced consultant-managers will enable you to choose the very products that totally suit your needs. Our managers will provide constructive suggestions so that your purchase served you for many years.
Come and see everything with your own eyes at 29 Zaliznychna str., Brody, Lviv region
Phone: 066 793 23 34.


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Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Pfisterer and colleagues1 reported that 1 year after either invasive treatment
or optimized medical therapy, elderly patients with angina had similar symptoms,
quality of life, and risk of death or nonfatal myocardial infarction. In contrast
with their previous report of 6-month outcomes,2 the
authors now report that patients who underwent medical therapy had a higher
risk of later hospitalizations for uncontrolled symptoms. The end point of
hospitalization seems reasonable, even though other primary and secondary
prevention studies did not use it.3- 5 Although
this makes the trial less comparable with previous results, the authors did
not discuss these differences.
Nash DT. Outcomes of Medical vs Invasive Therapy for Elderly Patients With Angina—Reply. JAMA. 2003;289(21):2794. doi:10.1001/jama.289.21.2794-a
© 2017


text:
LondonJem hasn't come back to VirtualTourist in a while.Meet other members!
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Katie45 Oct 21, 2011 at 9:16 AM
I am writing a paper for a class about Cairo. I have some specific things that I need to write about. For exampl; communication barriers, customs and social beliefs. I would love to put a couple of quotes in the paper from someone who has actually visited Cairo. Can you help out with some ideas? Thanks! K-
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text: The Baptist Board When my day is done and my work is through. I go to my computer and this is what I do. I go to the Baptist Board to meet my Christian friends. Who talk about Jesus Christ, who is their constant friend. The first one you'll meet is Barnabus, a kind and gentle soul. You're not the first to ask, No you cannot take him home. Then there is Dr. Bob, the dean, of barbs and quips. I hope you have a thick hide, he's faster than a whip. Our resident expert of biblical versions is Thomas Cassidy. But speak softly around others, he prefers the KJV Then there is Robert Vaughn, yeah he's read a book or two. Got questions on Baptist History, he's got the answer for you. Then there is Jeff Weaver who will pop in from time to time. I hear he is an Old Time Baptist of the feet washing kind. There is Pastor Larry, Preach the word and Fly free 432. There is Don, Chris and James2 and these few will have to do. No Baptist forum would be complete without the ladies fair. They come in all shapes and sizes and various shades of hair. The resident punster is da Gina she known to keep you in stitches. Watch her and what she says guaranteed to bust your britches. Helen is the resident scientist and she will speak about evolution She is also a Creationist and God is the only solution. We have a Saggy Woman, Javalady, Joy and Joy2. All ladies are a Keeper of My Home and we have her too. We have places for news, places for views as everyone has their own. Forums for new believers and those with no belief at all. There are many opinions and doctrines, to many to try to mention. Conversations get heated and arguments fly and there is a lot of tension. Three thousand members on the Baptist board in case you want to know. Now I want to introduce you to the one who runs the show. Brother Clint is a Christian gentleman and he will treat you kind and nice. Watch your tongue and your manners here as this is a Christian site. Now Brother Clint would not be complete without Margie his loving wife. The stories they've told and we all can tell she is the joy of his life. Last of all there's little me an Old Baptist till the end. When you see my name drop by and say hi… And we will talk about Jesus my friend Brother Glen


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If You're Not Here, Please Raise Your Hand
Poems About School Reprinted edition
By (author) Kalli Dakos
Illustrated by G. Brian Karas
Format: Paperback
Normal Price: $11.40
Your Price: $10.26 AUD, inc. GST
Shipping: $7.95 per order
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Availability: Available, ships in 8-11 days
If You're Not Here, Please Raise Your Hand by Kalli Dakos
Book DescriptionFor every student who's ever worried about spending a lifetime in the third grade and for every teacher who's faced a class where nobody remembered to bring milk money, these thirty-eight poems capture the excitement, challenge, heartbreak, and wonder of life in elementary school. Through her fresh, lively word pictures, Dakos manages to find surprises in every corner of the school.
Buy If You're Not Here, Please Raise Your Hand book by Kalli Dakos from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780689801167
(197mm x 133mm x 5mm)
Pages: 60
Imprint: Simon & Schuster
Publisher: Simon & Schuster
Publish Date: 1-Oct-1995
Country of Publication: United States
Other Editions...
» View all editions of If You're Not Here, Please Raise Your Hand...
Books By Author Kalli Dakos
Our Principal Promised to Kiss a Pig, Paperback / softback (March 2017)
In September, when the school principal promises to kiss a pig if the students read 10,000 books, a girl volunteers Hamlet, her unwilling, Shakespeare-quoting pet pig. But poor Hamlet wants nothing to do with such foolishness.
Put Your Eyes Up Here, Paperback (July 2006)
Dakos's trademark humor is in full force in this collection of poems that capture school life and all its trials and triumphs. Full color.
Bug in Teacher's Coffee and Other School Poems, Hardback (July 2002)
This collection of poetry for beginning readers reveals what "really" goes on at school: a pencil is held hostage in a desk, the school gym has a headache, and the class goldfish wants to visit Mexico. Full-color illustrations.
Don't Read This Book Whatever You Do!, Paperback (November 1998)» View all books by Kalli Dakos
Poems celebrate the world of education and the situations that occur in the elementary classroom.
» Have you read this book? We'd like to know what you think about it - write a review about If You're Not Here, Please Raise Your Hand book by Kalli Dakos and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Kalli Dakos
Kalli Dakos is an elementary school reading specialist who has written many books,including Mrs. Cole on an Onion Roll, illustrated by JoAnn Adinolfi, and two illustrated by G. Brian Karas: Don't Read This Book, Whatever You Do! More Poems About School and the Children's Choice Award-winning book If You're Not Here, Please Raise Your Hand: Poems About School. Kalli visits schools all over the United States and Canada to talk to students. She also gives teacher workshops. She lives in Ottowa, Canada ,and Sterling, Virginia. You can learn more about Kalli at www.kallidakos.com. G. Brian Karas has illustrated many children's books, including Muncha! Muncha! Muncha! And Tippy-Tippy-Tippy, Hide! by Candace Fleming; Incredible Me by Kathi Appelt; the High-Rise Private Eyes series by Cynthia Rylant; and Ivan by Catherine Applegate, which was a New York Times bestseller. His books have been named ALA Notables, Booklist Editor Choices, SLJ Best Books, and Boston Globe Horn Book Honor books. He lives in upstate New York. Visit him online at GBrianKaras.com.
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This year, The Young Folks has compiled its first ever Top 50 Albums list. The albums and their positions were chosen through balloting of six TYF writers: editor-in-chief Gabrielle Bondi, music editor Ryan Gibbs, film editor Allyson Johnson and music writers Joey Daniewicz, Jennifer Baugh and Matt Rice.
Before we get into the list proper, we have a handful of honorable mentions with a handful of albums that either just missed our list or were favorites of other members of our music staff.
Bastille's Wild World held the alternative scene this year in anticipation as they hyped up their second album. With Dan Smith's vocals as strong as ever, the group shares our views on 2016 and the "wild world" we live in. Wild World among the new pop-rock albums for the year, and reminded us of why we fell in love with them in the first place. – Reagan Harrison
Jeffrey not only sculpts Thug's voice in new melodic directions, it also pushes the boundaries of trap farther than anyone thought it ever could. Thug will scream, sing, contort his voice in ways that sound barely human, and then surround himself with a dizzying array of rock guitars, glittering pianos, and punky snare beats. The fact that he finds a way to make this concoction catchy is a testament to his talents, and most importantly it sounds vitally new. – Sean Romano


text:
If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
Learn more about our returns policy
Description: Relations between the press and politicians in modern America have always been contentious. In The Press Gang, Mark Summers tells the story of the first skirmishes in this ongoing battle. Following the Civil War, independent newspapers began to More...
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All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
List price: $37.95Copyright year: 1994Publisher: University of North Carolina PressPublication date: 6/24/1994Binding: PaperbackPages: 424Size: 6.25" wide x 9.50" long x 1.25" tall Weight: 1.496Language: English
Relations between the press and politicians in modern America have always been contentious. In The Press Gang, Mark Summers tells the story of the first skirmishes in this ongoing battle. Following the Civil War, independent newspapers began to separate themselves from partisan control and assert direct political influence. The first investigative journalists uncovered genuine scandals such as those involving the Tweed Ring, but their standard practices were often sensational, as editors and reporters made their reputations by destroying political figures, not by carefully uncovering the facts. Objectivity as a professional standard scarcely existed. Considering more than ninety different papers, Summers analyzes not only what the press wrote but also what they chose not to write, and he details both how they got the stories and what mistakes they made in reporting them. He exposes the peculiarly ambivalent relationship of dependence and distaste among reporters and politicians. In exploring the shifting ground between writing the stories and making the news, Summers offers an important contribution to the history of journalism and mid-nineteenth-century politics and uncovers a story that has come to dominate our understanding of government and the media.
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5364 S Milford Road,Milford OH, 45150
Sold Price
4 beds , 3 Full baths
3,134 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Professional Realty
(800) 599-8936
Last Updated: 2/24/2017 11:19 AM
Description for 5364 S Milford Road Milford, OH 45150
Move-in cond updtd turn-of-the-century farmhouse w wrap-around frnt sitting porch w mod amenities, new white kit w granite cntrs & hi-end gourmet ts/s apps, 10x9' w.i. pantry, hi ceilings, lots of windows, newer mechanics, 2nd flr laundry, 14x9' w.i.c.in MBR, neutral dcor, outbldg 1,300 sf 5-bay garage/utility bldg. w separate dedicated power.
Listing Information
Public Water Service
Natural Gas, Cable TV, 220v Service
School Information
Room Information
Family Room
Floor - W/W Carpet, Walk-In Closet, Dressing Area, Sitting Room
Floor - Wood
Floor - Wood, Formal
Floor - Linoleum/Vinyl, Eat-In Kitchen, Gourmet Kitchen, Butler Pantry, Island, Walkout, Fireplace
Shower Only, Floor - Marble
Interior Features
Range-Oven, Dishwasher, Garbage Disposal, Refrigerator, Microwave, Humidifier
Carpet Wall to Wall, Wood
Central Air, Ceiling Fan(s)
Gas Heat, Forced Air
Partial, Unfinished Basement, Walkout, Concrete
Insulated, Vinyl Frame
1, Gas Burning, Fireplace
Alarm -Smoke/Fire
Window Treatment, Crown Molding
Exterior / Lot Features
5 Garage Spaces, Detached Garage, Rear Entrance, Driveway
Wood, Vinyl
Deck, Porch, Deck/Patio
GolfCourse, Park
153 X 163 IRR, .5 to .9 Acres
Wood, Privacy Fence
Extra Storage, Barn
Financial Considerations
Inside AccessTM
Current market conditions for 5364 S Milford Road
Active Market Trends
Source:MLS DATA
Median list price$275,000
Days on market65
Properties for sale3
Sold Market Trends
Source:MLS DATA
Median sold price$132,750
Sales to list price9,620.0%
Properties sold20
Median sq ft price$99
Arrows indicate 90 day trend
Listing Price History for 5364 S Milford Road
Milford Real Estate
Milford is located in Ohio. Milford, Ohio 45150 has a population of 6,709.
The median household income in Milford, Ohio 45150 is $36,885. The median household income for the surrounding county is $60,590 compared to the national median of $53,046. The median age of people living in Milford 45150 is 39.5 years.
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|Video Games
|Games & Hobbies
IGN editors discuss all things Nintendo. Now you're playing with power!
September 23rd, 2016
Episode 268 of 286 episodes
The Nintendo NX is a codename, so what willbe its final name? We share our best guesses! Also: When other companiestry to do Metroid, Mario, and Zelda, it can be pretty cool. Or a total mess! We discuss.
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


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Backer Art
Wall Decor, metal wall art, metal wall decor
Backer "Art Off the Wall" is a collection of whimsical metal wall art that POPS off the wall using the wall to create a 3D effect. Small "feet" hold the art slightly off the wall so that, when light hits it, it casts a shadow on the wall causing the 3D effect.
All art is original by the Backers and is copyrighted and patented. So, you can always be sure you are getting something very unique.
The art is cut from a single piece of steel with no bends of welds to break or collect dust. Then, it's powder-coated in black so it will look great forever.
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Is Viridis Engineering India incorrect or missing key business information? Update your Hotfrog listing today.
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Is Viridis Engineering India in 6, GK Sundaram Street KK Pudur Saibaba Colony, Coimbatore Tamil Nadu 641038 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Lighting services in Coimbatore Tamil Nadu available on Hotfrog INDIA. You can update your search for Coimbatore Lighting by location, keyword or service options.
295 VR ARCADE NANJAPPA ROAD/RACE COURCE Coimbatore Tamil Nadu 641018
7/43-A, AVINASHI ROA AERODROME POST Coimbatore Tamil Nadu 641014
SB ROAD NANJAPPA ROAD/RACE COURCE Coimbatore Tamil Nadu 641018
57-A AERODROME ROAD, NEELIKONAMPALAYAM Coimbatore Tamil Nadu 641033
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Question about Samsung SGH-G600 Cellular Phone
Posted by al_01john on
Hello there,
If you contact you netowork provider and then request a PUK code then all good.
This is what I found on a forum:
"The PUK code relates to your SIM card, not the phone. If you enter the wrong for your SIM 3 times in a row, your SIM is blocked and you then require the PUK for your SIM.
There are a few ways to get your PUK. Firstly you can use our automated service to get this when calling 191 from your mobile. The PUK will then be provided by the system as long as you've set up a PIN on your account or registration and confirm this with the automated system when you call.
You could also e-mail us using the online contact us form here in the help section of our Vodafone.co.uk website.
Finally you could visit your nearest Vodafone store who'd provide you with your PUK once confirming your account security information with you."
I hope this helped.
Posted on Dec 07, 2008
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
a 6ya expert can help you resolve that issue over the phone in a minute or two.
best thing about this new service is that you are never placed on hold and get to talk to real repairmen in the US.
the service is completely free and covers almost anything you can think of (from cars to computers, handyman, and even drones).
click here to download the app (for users in the US for now) and get all the help you need.
Posted on Jan 02, 2017
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Join the 'Dimetane' group to help and get support from people like you.
Dimetane Questions
We found 2 questions associated with the 'Dimetane' topic.
Is it safe to give my child the dimetane dx and also Tylenol for fever ?
Posted 11 Mar 2015 by Cbell7684 • 1 answer
Is Dimetane still in the market? I understand Bromfenex is no longer in the market?
Posted 25 Oct 2009 by jeannepuerta • 2 answers
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Further Information
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Allergic Reactions, Urticaria, Hives, Hay Fever, Allergic Rhinitis, Cold Symptoms
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Brovex, Lodrane 24, J-Tan, Dimetane, Bidhist, Rohist, Lodrane 12 Hour, J-Tan PD, Prop-A-Tane, view more... Veltane, Respa BR, Histaject, Codimal A, Bromaphen, Tanacof-XR, VaZol, Dimetane Extentab, Dimetapp Allergy, Bromax, Siltane, Nasahist B, Brovex CT, LoHist-12, P-Tex, Cophene B, Lo-Hist 12, ND-Stat, B-Vex, Lodrane XR


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From Seregno (MB) to Bergamo Airport (Italy)
Help! I need to go from Seregno to Bergamo Airport next week by public transportation (either bus or train) and I've been searching everywhere but can't seem to find a website that will tell me which bus line or which is the best route to take.
I'd appreciate any help anyone can give me. Thank you in advance!
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The Integrated Dell Remote Access Controller 7 (iDRAC7) with Lifecycle Controller technology allows administrators to monitor, manage, update, troubleshoot and remediate Dell servers from any location
Dell is a direct partner to businesses and consumers, which delivers innovative technology and services.
Dell is a direct partner to businesses and consumers that deliver innovative technology and services.
The Dell Keep Your Hard Drive service enables businesses to retain a defective hard drive.
The Integrated Dell Remote Access Controller 6 (iDRAC6) is designed to improve the overall availability of Dell servers and to help system administrators save time.


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- By zbloodgoodeCollection
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FOREVER 21+ PLUS SIZES Spotted Safari Peplum Dress
$20 Sold out forever21.com
Forever 21+ - A leopard print dress featuring peplum sides. Scoop neckline and back. Sleeveless. Unlined. Knit. Lightweight. DETAILS: 39" approx. length from high point shoulder to hem, 34" chest, 33" waist. Measured from 1X. 95% polyester, 5% spandex. Hand wash cold, line dry. Imported.
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January 17, 2017
Authorities: Trooper was shot by driver he sought to help
The man who shot and severely beat an Arizona state trooper last week was a former member of the Mexican federal police who ...
January 16, 2017
AP Interview: Lynch defends push for police accountability
As a younger lawyer, Loretta Lynch prosecuted New York police officers who sodomized a Haitian immigrant in a precinct ...
January 15, 2017
Chicago police officer fatally shoots fleeing gunman
A police officer confronted by a fleeing gunman suspected of shooting three people fatally shot the man early Sunday, Chicago ...
January 14, 2017
AP Interview: Lynch says US must hold police accountable
As a younger lawyer, Loretta Lynch prosecuted New York police officers who sodomized a Haitian immigrant in a precinct ...
January 14, 2017
Chicago pledges improvements after scathing police report
Chicago officials are pledging to revamp the city Police Department following a scathing federal report, but a change in ...
January 14, 2017
Report says Chicago police violated civil rights for years
The Justice Department on Friday laid bare years of civil rights violations by Chicago police, blasting the nation's ...
January 14, 2017
Latest: Activists don't trust Chicago mayor to reform police
The Latest on the U.S. Department of Justice's report from its yearlong investigation into the Chicago Police Department (all ...
January 14, 2017
Feds: Excessive force a big problem for Chicago police
The Justice Department released the findings of its yearlong investigation into civil rights abuses by the Chicago Police ...
January 13, 2017
Filings: Pipeline opponents allegedly threatened officials
Police allege in court filings that opponents of the Dakota Access oil pipeline made threats against officers and public ...
January 13, 2017
Suit: Play about police violence, race sparks surveillance
A suburban New York community group says in a lawsuit it was racially profiled for producing a play about police violence ...
January 12, 2017
Baltimore police commits to sweeping changes in deal with US
The Baltimore police department committed to a sweeping overhaul of its practices Thursday under a court-enforceable ...
January 11, 2017
Officer won't be charged in killing of unstable black man
A suburban San Diego police officer won't face criminal charges for fatally shooting a disturbed black man, a prosecutor ...
January 11, 2017
Ex-LA County sheriff Baca faces retrial in corruption case
Former Los Angeles County Sheriff Lee Baca will be retried on obstruction of justice and other charges related to an effort ...
January 10, 2017
Paralyzed New York detective who became voice for peace dies
New York Police Department Detective Steven McDonald, who was paralyzed by a teenage gunman's bullet in 1986 but publicly ...
January 10, 2017
The Latest: Deputy killed responding to manhunt identified
The Latest on the shooting of a police officer in Orlando, Florida (all times local): 5:15 p.m. Authorities have identified ...
January 08, 2017
Israel's Netanyahu dismisses new set of corruption charges
Israeli Prime Minister Benjamin Netanyahu says there is nothing to a second police investigation into corruption charges.
January 07, 2017
Saudi police kill 2 suspected extremists in capital, Riyadh
Authorities in Saudi Arabia say police have shot and killed two suspected Islamic State extremists in the capital, Riyadh.
January 07, 2017
Suspect killed in police shootout on Chicago-area train
Authorities say a suspect in a Chicago-area slaying was killed in a police shootout on a Metra commuter train while dozens ...
January 06, 2017
Judge: Michael Brown's parents must release documents
Michael Brown's parents must turn over his academic and certain medical records as part of their lawsuit over his 2014 ...
January 06, 2017
Hate-crime charges filed in attack on mentally disabled man
Four black people were charged with hate crimes Thursday in connection with a video broadcast live on Facebook that showed ...


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iPhone apps
Aerolite Free
Aerolite Free brings unlimited levels of classic asteroid destroying fun to your iPhone and iPod touch. " .. the ship's acceleration, deceleration, and overall control are spot-on." -- www.toucharcade.comIncluded Features- Customizable game….. Read more
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'Hanimals Block Match' is a challenging gem-breaker-type game where you try to match as much animals as you can, features hours of gameplay and unlimited replay value. ---------------------… [more..]
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Data Deluge
Researchers Turn to Cloud Computing as Genomic Sequencing Data Threatens to Overwhelm Traditional IT Systems
Seeking Young Scientists for Research in Space
Sounds of Science Podcasts
Infectious Fight
Tackling the Inevitability of Resistance One Genome at a Time
Long Noncoding RNAs: Clarity or Confusion?
Because They Are Such Elusive Prey, lncRNAs Have Yet to Emerge as Therapeutic Targets
Helicon to Exploit Sapient's Structural Biology Expertise to Expedite Lead Design
Helicon Therapeutics is tapping into Sapient Discovery's structural biology expertise to unravel the 3-D structures of specific drug targets. Through the collaboration, the firm will provide Helicon with a complete array of x-ray crystallography and modeling services including cloning, expression, protein purification, and co-crystal structure determination.
Helicon is focused on the discovery of therapeutics to treat disorders of cognition through an understanding of the genetic basis of long-term memory formation. The firm says that structural data obtained from Sapient will help expedite structure-based lead design and optimization.
Sapient Discovery is exploiting its structural design expertise, large-scale structural databases, and leading-edge computational methodologies to help its partners accelerate the drug discovery and drug optimization processes.
In addition to structure determination services the company has developed its Genes To Leads™ service for accelerating lead discovery and target validation as well as the Fragments to Leads™ platform for generating novel lead molecules with x-ray crystallography and fragment libraries. StructureBank™ is a database for the large-scale comparative analysis of protein targets and antitargets.
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CALIFORNIA is the spiritual home of muscle-building and drug-taking. For more than 50 years, the Sunshine State has been the place where weightlifters, body-builders and athletes of all sizes, mostly big, have congregated, many of them at such celebrated centres as Muscle Beach near Los Angeles.
This was where, just over 40 years ago, the taking of anabolic steroids became rife, and so it was almost inevitable that the latest tissue drug, tetrahydrogestrinone (THG), should have originated on the West Coast of the United States. Its birthplace was the Burlingame sports laboratory near San Francisco.
Designer drugs have a slightly


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Jan 18, 2017
Moving the goalposts
Sports writer Carrie Dunn's book The Roar of the Lionesses explores women's football in England after the 2015 Women's World Cup. Hazel Davis had a kick about with her.
Jan 17, 2017
Diary of a fat lass: Stepping away from the stilton
Feeling crappy in head and body prompted Janine Rudin to make some changes in her life – and make the kinds of promises to herself that are keepers. This week, she's retrieving her step counter from the cheese board.
Jan 16, 2017
Present and incorrect
The idea of school attendance rewards is leaving Dotty Winters less than 100 per cent enthralled.
Jan 12, 2017
Body of evidence
When Taryn Brumfitt posted controversial 'after and before' pics on Facebook, they went viral. Here's what she did next.
Jan 11, 2017
Interior motives
When Roo Green moved in with her now-husband she hadn't reckoned on having to compromise her style.
Jan 11, 2017
Life goals = score! Look after that money, honey
In her column on dealing with life's challenges, life coach Karen Campbell explains why it's best to befriend your bucks.
Jan 10, 2017
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Motherhood hasn't come naturally to Daisy Leverington. Five years in and she remains wide-eyed, terrified and in awe of the little person she's responsible for. This week, anyone suggesting #NewYearNewYou changes can shit right off.
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It's crispy in Rutland and Helen Walmsley-Johnson's hugging some trees.
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All fans of Dr.Dre must have been overwhelmed with the news! Dr.Dre has FINALLY announced he is releasing his first album in 15 years!
All fans of Dr.Dre must have been overwhelmed with the news! Dr.Dre has FINALLY announced he is releasing his first album in 15 years!
The rapper announced the upcoming and so much anticipated album this weekend on his own radio show Beats 1. Dr.Dre said the album Compton: A Soundtrack will be released on 7 August.
But what is curious that it is different project, not Detox as we all thought during that time.
While talking live on air the rapper said that Detox wasn't good enough.
I don't think I did a good enough job, and I couldn't do that to my fans, and I couldn't do that to myself.
– said the singer.
Dr.Dre also narrated that he took inspiration for the new album Compton from the biographical movie of rap legends NWA.
The rapper also surprised the publicity, revealing other famous singers, including Eminem, Ice Cube, Kendrick Lamar and Snoop Dogg, who will feature on Compton.
Compton: A Soundtrack will be the first rapper's album since 1999's 2001.
Actually he had planned to return to music earlier, but delayed it numerously because of his work on his Beats headphones project. However, after Dr.Dre sold the headphone maker and music-streaming service to Apple last year, earning on it up to £2 billion, he is ready to return, presenting his new album to the world.
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Increased risk of venous thromboembolic events with corticosteroid vs biologic therapy for inflammatory bowel disease
Higgins P.D.R.,University of Michigan |
Skup M.,Abbvie Inc. |
Mulani P.M.,Abbvie Inc. |
Lin J.,Novosys Health |
Chao J.,Abbvie Inc.
Clinical Gastroenterology and Hepatology | Year: 2015
Background and Aims: We investigated whether treatment of active inflammatory bowel disease with biologic agents is associated with a reduced risk of venous thromboembolic events (VTEs) compared with corticosteroid therapy. Methods: We performed a retrospective analysis of 15,100 adults with inflammatory bowel disease who were identified from the Truven Health MarketScan databases. We analyzed data from patients who received 6 months of continuous medical and prescription coverage before and 12 months after their first diagnosis and had no VTE during the 6 months before they first received biologic or corticosteroid therapy. The outcome assessed was any VTE that occurred during the 12-month follow-up period. A multivariate logistic regression model was used to evaluate the effects of biologic, corticosteroid, and combination therapies (biologics and corticosteroids) on VTE risk. Results: Three hundred twenty-five VTEs occurred during the study period (in 2.25% of patients receiving only corticosteroids, in 0.44% of patients receiving biologics, and in 2.49% of patients receiving combination therapy). Compared with patients receiving only corticosteroids, the odds ratio for VTE in patients receiving only biologics was 0.21 (95% confidence interval, 0.05-0.87) in the multivariate model, and the odds ratio for VTE in patients on combination therapy was 1.01. Conclusions: Compared with treatment with only a biologic agent, corticosteroid therapy is associated with a nearly 5-fold increase in risk for VTE. Combination therapy with corticosteroids and biologic agents was associated with the same risk for VTE as that of corticosteroids alone. Corticosteroids therefore appear to increase risk for VTE. © 2015 AGA Institute. Source
Incremental cost burden to US healthcare payers of atrial fibrillation/atrial flutter patients with additional risk factors
Amin A.N.,University of California at Irvine |
Jhaveri M.,Sanofi S.A. |
Lin J.,Novosys Health
Advances in Therapy | Year: 2011
Introduction: Atrial fibrillation (AF) and atrial flutter (AFL) patients often have cardiovascular (CV) comorbidities, and have an increased risk of hospitalization and death. Little is known about the real-world cost burden of AF/AFL patients with additional risk factors (ARF). We evaluated the medical resource use and cost burden of AF/AFL patients with >1 ARF (other than heart failure [HF]), in comparison with non-AF/AFL controls. Methods: This retrospective cohort study included patients from the MarketScan Medicare database who had >1 inpatient or >2 outpatient AF/AFL claims. Patients were (1) >75 years of age or (2) 70-74 years of age with >1 ARF (hypertension, diabetes, systemic embolism, or stroke/transient ischemic attack), but without HF. The AF/AFL patients were matched on age, gender, region, and enrollment status with non-AF/AFL patients. Hospital resource use and costs over the 12-month post-index period were compared across cohorts. The impacts of comorbidity were seen by subcategorizing hospitalization as all-cause, CV-related, and AF/AFL-related. Results: AF/AFL patients with >1 ARF had a higher prevalence of comorbidity than non-AF/AFL patients (n=58,555/cohort). Hospitalizations (all-causality) were more than three times more frequent and of longer duration in AF/AFL patients with >1 ARF than in non-AF/AFL controls (mean [SD]: 0.72 [0.87] vs. 0.21 [0.51] hospitalizations per patient per year and 3.85 [9.30] and 1.03 [4.53] days, respectively; both P<0.0001). Overall mean (SD) costs over the 12-month post-index period were higher in AF/AFL patients with >1 ARF versus the non-AF/AFL control patients for inpatient (9613 [25,407] vs. 2625 [11,597]; P<0.0001; incremental cost 6988), outpatient (9447 [15,062] vs. 4906 [11,715]; P<0.0001; incremental cost 4541), and prescription drug costs (3430 [3637] vs. 2618 [3374]; P<0.0001; incremental cost 812). Conclusion: AF/AFL patients with >1 ARF had significantly greater levels of comorbidity, hospitalizations, prescription, and outpatient claims than non-AF/AFL patients. The incremental costs of AF/AFL patients with >1 ARF are largely due to higher CV-related inpatient costs. © 2011 Springer Healthcare. Source
Amin A.N.,University of California at Irvine |
Jhaveri M.,Sanofi S.A. |
Lin J.,Novosys Health
American Journal of Therapeutics | Year: 2013
The aim of the study was to examine the temporal readmission pattern, proportion of readmissions attributed to cardiovascular (CV) causes, and the duration and costs associated with readmission in hospitalized patients with atrial fibrillation/flutter (AF/AFL). This retrospective cohort study used medical claims data from the PharMetrics Patient-Centric database (IMS Health, Watertown, MA) between January 2007 and March 2008. The patients hospitalized with a primary diagnosis of AF/AFL and with ≥12 months' continuous medical and prescription coverage before and after the initial AF/AFL hospitalization were identified from this database. The main outcome measures were rehospitalization patterns [all-cause, all CV-related (including AF/AFL), and AF/AFL-related only], which were assessed over the 12-month post-index period, and costs of initial and subsequent AF/AFL-related hospitalizations that were compared. The study included 8035 patients with AF/AFL (mean age 66.1 years; 57.6% males). Rehospitalization was common (37.9% of patients), with the most frequent causes being CV (34.1%) and, specifically, AF/AFL-related (26.8%). The highest proportion of rehospitalizations occurred within 30 days of the initial hospitalization (25%). Readmissions with a primary diagnosis of AF/AFL (n = 1238) were significantly longer (4.0 vs. 3.6 days; P = 0.0229) and more costly (US$8966 vs. US$7080; P < 0.0001) than the index hospitalization. Hospitalized AF/AFL patients experience high rates of CV- and AF/AFL-related readmissions, particularly within the first 30 days. Subsequent AF/AFL-related readmissions incur higher costs than the initial AF/AFL hospitalization. Treatments resulting in reduced readmissions would improve patient outcomes, quality of life and the cost burden associated with AF/AFL. © 2013 Lippincott Williams & Wilkins. Source
Incidence and predictors of venous thromboembolism (VTE) among ambulatory high-risk cancer patients undergoing chemotherapy in the United States
Khorana A.A.,University of Rochester |
Dalal M.,Sanofi S.A. |
Lin J.,Novosys Health |
Connolly G.C.,University of Rochester
Cancer | Year: 2013
Background: Recent studies suggest that thromboprophylaxis is beneficial in preventing venous thromboembolism (VTE) in cancer outpatients, but this is not widely adopted because of incomplete understanding of the contemporary incidence of VTE and concerns about bleeding. Therefore, the authors examined the incidence and predictors of VTE in ambulatory patients with bladder, colorectal, lung, ovary, pancreas, or gastric cancers. Methods: Data were extracted from a large health care claims database of commercially insured patients in the United States between 2004 and 2009. Demographic and clinical characteristics of the cancer cohort (N = 17,284) and an age/sex-matched, noncancer control cohort were evaluated. VTE incidence was recorded during a 3-month to 12-month follow-up period after the initiation of chemotherapy. Multivariate analyses were conducted to identify independent predictors of VTE and bleeding. Results: The mean age of the study population was 64 years, and 51% of patients were women. VTE occurred in 12.6% of the cancer cohort (n = 2170) over 12 months after the initiation of chemotherapy versus 1.4% of controls (n = 237; P <.0001); incidence ranged by cancer type from 19.2% (pancreatic cancer) to 8.2% (bladder cancer). Predictors of VTE included type of cancer, comorbidities (Charlson Comorbidity Index score or obesity), and commonly used specific antineoplastic or supportive care agents (cisplatin, bevacizumab, and erythropoietin). Conclusions: This large, contemporary, real-world analysis confirmed high rates of VTE in select patients with solid tumors and suggested that the incidence of VTE is high in the real-world setting. Awareness of the benefits of targeted thromboprophylaxis may result in a clinically significant reduction in the burden of VTE in this population. Cancer 2013. © 2012 American Cancer Society. Source
Temporal pattern and costs of rehospitalization in atrial fibrillation/atrial flutter patients with one or more additional risk factors
Amin A.N.,University of California at Irvine |
Jhaveri M.,Sanofi S.A. |
Lin J.,Novosys Health
Journal of Medical Economics | Year: 2012
Objectives: The ATHENA study showed that use of dronedarone reduced rates of first cardiovascular (CV) hospitalization in atrial fibrillation/flutter (AF/AFL) patients. AF is associated with high costs to payers, which are driven by high rates of hospitalization. This retrospective cohort study examined readmission patterns and costs to US payers in real-world AF/AFL patients with ≥1 additional risk factor (ARF). Methods: Patients hospitalized (January 2005March 2008) with AF/AFL as primary diagnosis and having ≥1 year of health coverage, before and after their first (index) admission, were identified in the PharMetrics Patient-Centric database. As in the ATHENA study, patients had to be ≥75 years of age or ≥70 years, with ≥1 ARF. Rehospitalization patterns (all-cause, all CV-related [including AF/AFL] and AF/AFL-related alone) were examined over 1 year post-index, and costs of index vs later AF/AFL admissions compared. Results: The study included 3498 patients (mean 80 [SD 7.6] years; 42.4% men). Over 1 year, 1389 patients (39.7%) were rehospitalized for any cause (mean 1.7 [SD 1.3] events/patient), with 1223 patients (35.0%) undergoing CV-related (mean 1.6 [SD 1.0] events/patient) and 935 (26.7%) undergoing AF-related rehospitalization (mean 1.4 [SD 0.8] events/patient). Common causes of CV-related readmissions (primary diagnosis) were AF/AFL (47.5%), congestive heart failure (CHF) (9.9%), coronary artery disease (7.4%), and stroke/transient ischemic attack (6.2%). Readmission rates at 3 months were 16.2% (all-cause), 14.3% (all CV-related including AF/AFL), and 10.5% (AF/AFL-related alone). AF/AFL readmissions (primary diagnosis) were longer than initial hospitalizations (mean total 6.9 [SD 12.9] vs 4.3 [SD 5.1] days, p<0.0001) and more costly (median $1819 [25th percentile $1066, 75th percentile $5623] vs $1707 [25th percentile $1102, 75th percentile $4749]). Limitations: This study excluded patients with pre-existing CHF, did not require electrocardiogram confirmation of AF/AFL diagnosis, and did not distinguish between paroxysmal, persistent, and permanent AF. Conclusions: AF/AFL patients with ≥1 ARF have high readmission rates. AF/AFL-related readmissions incur higher costs than the initial AF/AFL admissions. © 2012 Informa UK Ltd All rights reserved. Source