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The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development
Jepsen M.R.,University of Aarhus |
Kloverpris S.,University of Aarhus |
Botkjaer J.A.,Copenhagen University |
Wissing M.L.,Holbaek Fertility Clinic |
And 2 more authors.
Human Reproduction | Year: 2016
STUDY QUESTION Is the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) regulated by the stanniocalcins (STC1 and STC2) during human follicle maturation? SUMMARY ANSWER The STCs and PAPP-A show similar expression by immunohistochemistry in developing follicles, and regulation of PAPP-A proteolytic activity is suggested by the identification of inhibited protein complexes between PAPP-A and STC1 or STC2 in human follicular fluid (FF). WHAT IS KNOWN ALREADY The insulin-like growth factor (IGF)-regulating proteinase PAPP-A is secreted by the granulosa cells of estrogen-dominant follicles and is involved in follicle growth. STC1 and STC2 have recently been identified as novel PAPP-A inhibitors, and their expression in non-human mammalian ovaries has previously been observed. STUDY DESIGN, SIZE, DURATION The proteolytic activity of PAPP-A in human follicular fluid was assessed, and the interaction between PAPP-A and the STCs in human ovarian tissues and follicular fluid was analyzed using immunoassays. From 21 women, matched pairs of follicular fluid were obtained from one follicle just prior to final maturation of follicles with human chorionic gonadotrophin (hCG), and from another follicle in connection with oocyte aspiration after hCG treatment. Ovarian tissues were obtained from women having one ovary removed for fertility preservation by cryopreservation prior to gonadotoxic treatment. PARTICIPANTS/MATERIALS, SETTING, METHODS The concentration and activity of PAPP-A were determined in all samples of follicular fluid. Furthermore, to investigate PAPP-A regulation during follicle development, immunohistochemical staining of PAPP-A, STC1, and STC2 was performed on pre-antral and antral human follicles. To attempt the demonstration of native complexes between PAPP-A and the STCs, immunoprecipitation from a pool of human follicular fluid was performed. MAIN RESULTS AND THE ROLE OF CHANCE The concentration of PAPP-A antigen in follicular fluid increased upon stimulation of ovulation with hCG (P < 0.02), but at the same time, PAPP-A activity was decreased. PAPP-A, STC1, and STC2 were localized together in primordial, late primary, and antral follicles, indicating that complex formation is possible in ovarian tissue. Covalent PAPP-A:STC2 and non-covalent PAPP-A:STC1 complexes were immunoprecipitated from follicular fluid, documenting for the first time native inhibited complexes between PAPP-A and the STCs. LIMITATIONS, REASONS FOR CAUTION We have demonstrated the presence of native complexes between PAPP-A and the STCs in the human ovary, indicating STC-mediated PAPP-A proteolytic inhibition. Further investigation is required to extend this principle to other tissues. WIDER IMPLICATIONS OF THE FINDINGS Our data suggest that the STCs contribute to PAPP-A regulation during folliculogenesis and support a general model in which STC1 and STC2 are regulators of mammalian IGF activity through inhibition of PAPP-A. We suggest that future functional studies take both PAPP-A and the STCs into consideration. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. Source
Pregnancy-associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels
Botkjaer J.A.,Copenhagen University |
Jeppesen J.V.,Copenhagen University |
Wissing M.L.,Holbaek Fertility Clinic |
Kloverpris So.,University of Aarhus |
And 4 more authors.
Fertility and Sterility | Year: 2015
Objective To evaluate follicular fluid (FF) levels of pregnancy-associated plasma protein A (PAPP-A) in relation to levels of intrafollicular hormones. Furthermore, immunostaining of human follicles of varying diameters was studied for PAPP-A, antimüllerian hormone (AMH), and aromatase, and the biological activity of PAPP-A in FF was evaluated. Design Laboratory investigation. Setting University hospital. Patient(s) A total of 43 women with a total of 80 samples were obtained from three different size-groups of antral follicles collected before and after the LH surge. Intervention(s) ELISA measurement of steroids, PAPP-A, and AMH, immunohistochemistry of PAPP-A, AMH, and aromatase on follicles of different diameter, and proteolytic activity of PAPP-A toward insulin-like growth factor (IGF)-binding protein 4 (IGFBP-4). Main Outcome Measure(s) Association between FF levels of PAPP-A and measured ovarian hormones, PAPP-A activity in FF, localization of PAPP-A, AMH, and aromatase in antral follicles. Result(s) A highly significant association between FF levels of PAPP-A and all measured hormones were obtained with positive associations toward E2 and P, whereas AMH, T, and A showed strong negative associations. PAPP-A proteolytic activity toward IGFBP-4 was detected in human FF. PAPP-A immunostaining shifted from being primarily present in theca cells of small antral follicles to being expressed in granulosa cells (GCs) of preovulatory follicles. In contrast, AMH expression became reduced with increasing follicular diameter. Aromatase expression was highly specifically localized to GCs of preovulatory follicles. Conclusion(s) The results suggest that PAPP-A is specifically involved in the regulation of steroidogenesis in human antral follicles. Local regulation of IGF-II activity may represent a mechanism by which PAPP-A exerts this function and highlights the importance of IGF signaling during follicular development. © 2015 American Society for Reproductive Medicine. Source
The transcriptome of corona radiata cells from individual MІІ oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women
Wissing M.L.,Holbaek Fertility Clinic |
Sonne S.B.,Copenhagen University |
Westergaard D.,Technical University of Denmark |
Nguyen Kd.,Technical University of Denmark |
And 3 more authors.
Journal of ovarian research | Year: 2014
BACKGROUND: Corona radiata cells (CRCs) refer to the fraction of cumulus cells just adjacent to the oocyte. The CRCs are closely connected to the oocyte throughout maturation and their gene expression profiles might reflect oocyte quality. Polycystic ovary syndrome (PCOS) is a common cause of infertility. It is controversial whether PCOS associate with diminished oocyte quality. The purpose of this study was to compare individual human CRC samples between PCOS patients and controls.METHODS: All patients were stimulated by the long gonadotropin-releasing hormone (GnRH) agonist protocol. The CRC samples originated from individual oocytes developing into embryos selected for transfer. CRCs were isolated in a two-step denudation procedure, separating outer cumulus cells from the inner CRCs. Extracted RNA was amplified and transcriptome profiling was performed with Human Agilent® arrays.RESULTS: The transcriptomes of CRCs showed no individual genes with significant differential expression between PCOS and controls, but gene set enrichment analysis identified several cell cycle- and DNA replication pathways overexpressed in PCOS CRCs (FDR < 0.05). Five of the genes contributing to the up-regulated cell cycle pathways in the PCOS CRCs were selected for qRT-PCR validation in ten PCOS and ten control CRC samples. qRT-PCR confirmed significant up-regulation in PCOS CRCs of cell cycle progression genes HIST1H4C (FC = 2.7), UBE2C (FC = 2.6) and cell cycle related transcription factor E2F4 (FC = 2.5).CONCLUSION: The overexpression of cell cycle-related genes and cell cycle pathways in PCOS CRCs could indicate a disturbed or delayed final maturation and differentiation of the CRCs in response to the human chorionic gonadotropin (hCG) surge. However, this had no effect on the in vitro development of the corresponding embryos. Future studies are needed to clarify whether the up-regulated cell cycle pathways in PCOS CRCs have any clinical implications. Source
Wissing M.L.,Holbaek Fertility Clinic |
Bjerge M.R.,Holbaek Fertility Clinic |
Olesen A.I.G.,Holbaek Fertility Clinic |
Hoest T.,Holbaek Fertility Clinic |
Mikkelsen A.L.,Holbaek Fertility Clinic
Reproductive BioMedicine Online | Year: 2014
This study investigated whether polycystic ovary syndrome (PCOS) affected early embryo development assessed by time-lapse analysis of embryo kinetics from fertilization to the blastocyst stage. This was a prospective cohort study of two pronuclei (2PN) embryos from 25 hyperandrogenic PCOS patients (110 2PN embryos), 26 normoandrogenic PCOS patients (140 2PN embryos) and 20 healthy, regularly cycling women (controls, 97 2PN embryos). Patients underwent the same baseline evaluation and the same ovarian stimulation from April 2010 to February 2013. Oocytes were fertilized by intracytoplasmic sperm injection and incubated in an EmbryoScope with pictures taken every 20 min in seven focal planes. Time to 2PN breakdown, first cleavage and cleavage to 3, 4, 5, 6, 7 and 8 cells, morula and blastocyst (t2, t3, t4, t 5, t6, t7, t8, tM, t B) were annotated. Differences in embryo kinetics between groups were assessed by mixed modelling. Compared with controls, embryos from hyperandrogenic PCOS patients were significantly delayed at 2PN breakdown, t2, t3, t4 and t7 but not at t 5, t6, t8, tM or tB. Embryos from hyperandrogenic PCOS women had developed slower from fertilization to the 8-cell stage compared with embryos from controls. We investigated whether polycystic ovary syndrome (PCOS) affected early embryo development assessed by time-lapse analysis of embryo kinetics from fertilization to the blastocyst stage. This was a prospective cohort study of two pronuclei (2PN) embryos from 25 hyperandrogenic PCOS patients (110 2PN embryos), 26 normoandrogenic PCOS patients (140 2PN embryos) and 20 healthy, regularly cycling women (controls, 97 2PN embryos). Patients underwent the same baseline evaluation and the same ovarian stimulation from April 2010 to February 2013. Oocytes were fertilized by intracytoplasmic sperm injection and incubated in an EmbryoScope with pictures taken every 20 min in seven focal planes. Time to 2PN breakdown, first cleavage, cleavage to 3, 4, 5, 6, 7 and 8 cells, morula and blastocyst (t2, t3, t4, t5, t6, t7, t8, tM, tB) were annotated. Differences in embryo kinetics between groups were assessed by mixed modelling. With mixed modelling, the 'patient factor' is adjusted for, as each patient contributed several embryos for analysis. Compared with embryos from controls, embryos from hyperandrogenic PCOS patients were significantly delayed at 2PN breakdown (P = 0.0128), t2 (P = 0.0061), t3 (P = 0.0171), t4 (P = 0.0017), t7 (P = 0.04) and but not at t5, t 6, t8, tM or tB. We concluded that embryos from hyperandrogenic PCOS women developed slower from fertilization to the 7-cell stage compared with embryos from controls. The clinical impact of the embryo delay was unknown, since this study was not powered to detect differences in implantation and pregnancy rates between groups. © 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Source


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Still healthy demand for UK Government bonds - Treasury
Thursday 28th January 2010
Treasury minister Stephen Timms said there was still a healthy demand for Government bonds, despite Britain's record deficit.
He spoke out after Bill Gross, managing director at Pimco, the world's biggest bond house, said UK gilts were "resting on a bed of nitroglycerine" as a result of the nation's high debt levels and advised against buying them, the Daily Telegraph reports.
"We have continued to see a good level of demand for gilts," Timms said. "I only point to the fact that our auctions have been well covered and I am confident that we will continue to meet our needs."
Click here to read full report in the Telegraph
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Editorial Contact Details - Conor Shilling
Timing the market? 'Pound cost averaging' can make life easy
The FTSE at an all-time high - great news, provided your 'home' currency is sterling
Payment scams – have the banks been let off the hook?
Demystifying the art of copying most profitable traders and Winning!

subset: commoncrawl


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Used Alfa Romeo cars for sale in Steyning
We currently have 1 used Alfa Romeo car available in Steyning. With the widest range of private and trade Alfa Romeo cars available in Steyning, you have access to the biggest choice and the best prices.
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Alfa Romeo Giulietta 1.4 TB MultiAir Veloce 5dr
2011 (11 reg) Hatchback
This is a lovely well looked after example with tints and double sunroof in the best colour. Selling as we no longer need 2 cars, 2 owners, Next MOT due 02/07/2017, Electric windows, …
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We currently have: 1 Used Alfa Romeo car available in Steyning on Auto Trader


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|Page (1) of 1 - 08/07/03
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Minolta Intros DiMage Digital CamerasNew models offer higher resolution, increased memory
Minolta today introduced four new models in its line of DiMage digital cameras. These include two higher-end 5-megapixel models, as well as two 3.2-megapixel cameras. All are expected to ship in September.
Heading up Minolta's new lineup is the new A1, built upon the DiMage 7 series of cameras. The new model is an SLR-style camera offering a 5-megapixel resolution, built-in f2.8-3.5 7x optical zoom lens, a top shutter speed of 1/16,000 second, dual-focal macro system, extra-fine image-quality option, Minolta's new CxProcess II and 3-D Predictive Focus Control, Subject Tracking AF, Anti-shake function and compatibility with portable and studio flash systems. Its apochromatic lens employs anomalous dispersion (AD) glass designed to minimize chromatic aberration at all focal lengths. It also incorporates direct manual focus for fine tuning, as well as a new Flex Digital Magnifier for enlarging a section of a live image for focusing. It will sell for $1,199.
The DiMage G500 also offers a 5-megapixel resolution. It includes a 3x aspheric zoom lens with seven elements in six groups and offers a dual-slot card system for either Memory Stick or SD media (or both) for up to 640 MB of storage. The G500 also features manual controls for exposure, saturation, contrast, sharpness and color balance. It measures 3.7" x 2.2" x 1.2". It will sell for $499.
Minolta has also introduced the new Z1, a 3.2-megapixel camera. Minolta says the Z1 is the first in a new series of SLR-style cameras designed for ease of use. The camera includes a built-in f/2.8-3.5 10x zoom lens plus 4x digital zoom. (An optional 0.75x wide-converter is also available.) Other features include:
- Super Macro mode for capturing images as close as 1.6 inches;
- Ability to capture 30 FPS VGA-resolution movies;
- CxProcess II image processing technology;
- 60 FPS sampling rate for determining optimal focus;
- Progressive Capture drive system for capturing images continuously to buffer memory;
- Shutter release lag of 0.06 seconds.
The Z1 will run $399.
Finally, Minolta has also introduced the fully automatic DiMage E323, a compact camera offering a 3.2-megapixel resolution. It includes a seven-element f/2.8-4.9 3x optical zoom lens (plus 4x digital zoom), along with a macro mode that allows for shooting a subject as close as 4.3 inches. It can also capture movies at up to 320 x 240 resolution. It will sell for $279.
Further specs are available on the Minolta's Web site. For more information, visit http://www.minoltausa.com.
Contact the author: Dave Nagel is the producer of Creative Mac and Digital Media Designer; host of several World Wide User Groups, including Synthetik Studio Artist, Adobe Photoshop, Mac OS, Adobe InDesign, Adobe LiveMotion, Creative Mac and Digital Media Designer; and executive producer of the Digital Media Net family of publications. You can reach him at email@example.com.
Page: 1
Related Keywords:Minolta Intros DiMage Digital Cameras
Source:Digital Media Online. All Rights Reserved


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A team of psychiatrists at the Massachusetts General Hospital Depression Clinical and Research Program will examine the effect of Bikram Yoga on depression, quality of life, and functioning, in addition to common physiological markers associated with depression.
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Dresses 2013
Εξερευνήστε σχετικά θέματα
hi low wedding dresses | Tulle Applique High Low Ivory Wedding Dresses 2013
Style No. 213261 ~ Charlene, Wedding Dresses 2013 Collection - Strapless lace appliqué, tulle and velvet A-line wedding dress with illusion and scalloped lace over a sweetheart neckline, hand-beaded corded lace appliqué dropped waist bodice features a velvet ribbon at natural waist adorned with a side three-dimensional lace motif accented with jeweled beading, low dipped back bodice, matching beaded lace appliqués cascade down skirt to scalloped hemline and chapel length train.
ive never tried this dress on before. I should, lol
shiny shiny sparkly wedding dress …
Style No. 213253 ~ Marta, Wedding Dresses 2013 Collection - All over embroidered lace, tulle and organza A-line wedding dress with lace cap sleeves and scalloped V-neckline, plunging dramatic scalloped V-back neckline, thin organza natural waistband adorned with center hand-beaded jeweled motif, scalloped hemline spills into chapel length train. The Berger Collection for Mon Cheri headpiece style 9465 and veil style 9492 sold separately.
Style No. 213243 ~ Macaria, Wedding Dresses 2013 Collection - Luxurious satin, tulle and lace appliqué A-line wedding dress with lace cap sleeves, sweetheart neckline trimmed with delicate hand-beading, embroidered lace appliqué bodice with beaded accents and dropped waistline, detailed sheer tulle and lace back bodice with trailing covered button closures, matching beaded lace appliqués cascade down skirt to chapel length train.
Wedding Dresses 2013 Collection - David Tutera 213248 - Parker. Tulle, organza and lace appliqué wedding dress ball gown features illusion and lace cap sleeves and V-neckline trimmed with intricate hand-beading,
Stunning Abed Mahfouz Wedding Dresses 2013
Gallery Princess Bride - Wedding Dresses 2013
Style No. 213252 ~ Petunia, Wedding Dresses 2013 Collection - Strapless allover delicately hand-beaded lace and tulle A-line wedding dress with scalloped sweetheart neckline and low dipped back bodice, skirt features scattered beading, a scalloped hemline and chapel length train, detachable spaghetti and halter straps included.


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Freakshow Vaults
Freakshow Vaults
This Halloween experience London's first FREAKSHOW CLUBARET party.
An immersive theatrical party experience like no other. Get dressed up in your most spectacular costume and prepare to party like the possessed as you enter our spectacular world of theatre, music and fun.
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Tag: Defense
Statement on Meeting with British Prime Minister Theresa MayJanuary 26, 2017
"It was an honor to welcome Prime Minister May to Philadelphia." Read More
It's Official: The Biggest Pay Raise For Our Troops in Six YearsDecember 23, 2016
"We can all be glad that our troops will finally receive their largest pay raise in six years." Read More
The Iran Sanctions Extension Act Is Now Law—No Thanks to President ObamaDecember 15, 2016
President Obama once again signaled to the world that he won't stand up to the mullahs. Read More
The largest pay raise for our troops in six yearsDecember 02, 2016
"I'm particularly proud that this NDAA includes the largest pay raise our troops have seen in six years—and it's well-deserved." Read More
Statement on Selection of General James Mattis to Serve as Defense SecretaryDecember 02, 2016
"General Mattis is exactly the right choice to lead the Pentagon after eight years of fecklessness under President Obama." Read More
The largest pay raise for our troops in 6 yearsDecember 01, 2016
The brave men and women who serve our country in uniform put their lives on the line to keep us safe. The way we see it, a raise is the least we can do. Read More
This is about our troopsDecember 01, 2016
This bill, which continues a more than five decade tradition of bipartisan support, funds our troops and helps keep Americans safe. Read More
House Leaders Ask President Obama to Halt Concessions to IranNovember 22, 2016
"We respectfully request that your administration take no further actions designed to bolster international investment in Iran." Read More
Statement on Pentagon's Announcement on Veteran BonusesOctober 26, 2016
Congress will continue to work on any reforms necessary to ensure this doesn't happen again. Read More
Statement on Veteran BonusesOctober 25, 2016
"The Pentagon should immediately suspend efforts to recover these overpayments" Read More


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Articles - Recent Comments
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Will any MP3 player ever catch Apple's iPod?
"The iRiver iHP-100, which is the company's first stab at the hard drive market, sits between the iPod and Zen NX in many ways. The sound quality is not quite on par with Creative's, but is better than Apple's. It is slightly larger than the iPod, but a good bit smaller than the Zen NX. However, in terms of straight features and abilities it beats the hell out of both.
No player is more versatile than the iHP-100. From the digital optical in and out to the insane menu system, there is nothing you could ask of a portable that isn't in the iHP-100. This is something iRiver is famous for, and the company didn't hold back with the iHP-100.
Another big draw is that the iHP-100 shows up as a generic hard drive. You don't need any software or drivers; you simply drag and drop.
Unfortunately, the very things that make this such an impressive device also make it the most expensive in the shootout. Make no mistake: This is the Starship Enterprise of hard drive portables. However, you pay out the ass for it.
The iHP-100 is my daily player. And if you aren't on a budget, then I recommend it without reservation. However, the price will turn many people off."
Posted by reviews on October 14, 2003 at 3:48 PM (CDT)
Will any MP3 player ever catch Apple's iPod?
"Compared to the iPod or iRiver the Zen NX is a beast. It is a good deal larger and heavier, which makes it harder to tote around. Creative includes a carrying case, but that just makes it bigger.
Two things make the Zen NX a great player. Firstly, the sound quality is second to none. It is loud and clear as a bell. Invest in a decent set of headphones and you'll be happy as a clam. Secondly, it offers stunning value. The larger capacity model is the same price as the entry iPod and much cheaper than the iRiver.
Creative also packed the Zen with features. It is not as robust as the iRiver, but it is equipped with plenty of sound and playback options.
I recommend the Zen to anyone looking for a good deal. I also recommend it to those of you who place the highest priority on sound quality. It's not as slick as the iPod or as well-endowed as the iRiver, but I think the sound and cost make it a very practical solution."
Posted by reviews on October 14, 2003 at 3:47 PM (CDT)
Will any MP3 player ever catch Apple's iPod?
Comparison review of iPod, Zen, iHP
"The iPod is a funny device. Apple has done an excellent job marketing it, and it is wildly popular, but in a lot of ways it is not such a great player. It does, however, look hella cool, which is enough for many people. The iPod excels in portability and ease of use. All versions are small and light. Of these three players the iPod is the easiest to carry around with you. The menu system is simple and the touch-sensitive scroll wheel makes navigation a snap.
The drawbacks are battery life and sound. It plainly doesn't sound as good as the Zen NX or iRiver. The battery life gets shorter and shorter with each generation of iPod. Apple's claim is eight hours, depending on use.
I recommend the iPod to users working with a good size budget and not looking for a long list of features. If you want something that will simply play your songs, and don't want to hassle through a complex menu system, then the iPod is for you. I also recommend it to anyone looking to pick up techie girls or boys."
Posted by reviews on October 14, 2003 at 3:46 PM (CDT)
iPod Adventures in the Middle East: Part I
Would just like to know if Ipod prices in the Middle East are cheaper than the US.
Posted by rush on October 14, 2003 at 8:09 AM (CDT)
Experiment: iPod Video Capture?
I too was getting sick of juggling a dozen CF cards and booting up the laptop in dubious terrain to empty them while worrying about remaining battery was getting old fast.
I tried using the ArchosAV 340 - the 4" screen is good and the video out quality is acceptable, but it was a little bulky and at $600 was a little spendy for me.
I ebay'd it and got a Lyra instead. $400, screen not so good, but video out quality seems better. Longer battery life, same Compact Flash slot, and the unit is a lot more compact. I swapped out the 20GB drive for an 80GB drive. Has no problem accepting CF cards from my Canon, or recording from a direct Composite video feed from my Sony.
Posted by VidGuy on October 13, 2003 at 1:46 PM (CDT)
Experiment: iPod Video Capture?
P.S. For a very portable DV capturing system check out MCE's Quickstream DV http://www.powerbook1.com/quickstreamdv.html
Posted by Eris on October 13, 2003 at 12:44 PM (CDT)
Experiment: iPod Video Capture?
I came to this site asking the same question as Micheal. Does anyone know the answer? I have looked on this site but haven't found any posts that address the question. My idea is to use an iPod, a dual female firewire adapter, and a firewire CF card reader to provide a storage solution for when I am out shooting with my digital camera. Will this work? Does anyone have any suggestions? Thanks.
Posted by Eris on October 13, 2003 at 9:51 AM (CDT)
iPod Adventures in the Middle East: Part I
I havent posted here in a while. I'm still waiting for the 2nd part of this story. I just started university a few weeks ago. my pod goes everywhere with me. I'm the only one that has it in my university. I've gotten some attention from it. I havent had any problems with it temperature wise yet, and I listened to it on the plane just fine. I've scratched the cover and screen, but that isnt bothering me, unless my pod stops working, i'll be fine. I still need to visit the Apple store here (in Lebanon). Peace.
Posted by Patrick on October 12, 2003 at 5:27 AM (CDT)
Will any MP3 player ever catch Apple's iPod?
Yes, I just got a 3G 15 GB ipod. I'm trying to figure out what I can do with it. Are there more games I could download somewhere? And WHY is it that Macs can't hold charge? I'm a born and bred mac user, but but my sister's clam shell ibook ran for about 2 hours and quit. I'm having problem with my ipod now. It runs for about 2 hours after being fully charged. I just want to make the most out of my iPod and I'm not much of a techie. Just some advice on cool things I can do with it and easily explain features to everyone in my town (yes, it's small, no one knows what they are, no one uses macs, and I am the first with an Ipod.)
Posted by Kat on October 10, 2003 at 3:47 PM (CDT)
iPod Adventures in the Middle East: Part I
in december im going to go to the states to get me a 20GB ipod…and if i have enough money…im going to get a 40GB…i just have to hurry and sell my two guitars… :S ...i hope its worth the wait…from all the pictures…it looks really kool…
Posted by Thatguy on October 9, 2003 at 3:36 PM (CDT)
Switching from MP3 to AAC Without Losing Your Mind
I see the new Napster supports WMA and not AAC. THis is a problem for people who want to move music from Napster to the iPod.
You could just do what I do with Media Center 9 and protected audio files like WMA or AAC: play them in one channel, and record the WAVs using another channel and automatically transcode into MP3. Sure it's an analog process, but the quality is top-notch and I honestly can't tell the difference between the original digital files and my analog->digital copies.
This is also why Rhapsody is more valuable to me than iTMS—for $10 a month I get a choice of 300K songs, and I can record them into MP3s at will.
Posted by MC9 on October 9, 2003 at 12:54 PM (CDT)
My iPod Buying Experience
I tried the new itrip from Griffin technolgoies and it's AWESOME. Very easy to use and program and sounds as clear as the stereo you are using it on. It's amazing never could believe anything wireless like this could sound this GREAT!!
Posted by Jennifer on October 9, 2003 at 11:49 AM (CDT)
iPod Adventures in the Middle East: Part I
Im a police officer in the uk, love the pod and all things pod.
I listen to the pod going to work,,,,,,,,,,,,,,,hip hop and garage
Going home…cool jazz
Posted by robster on October 8, 2003 at 7:16 PM (CDT)
Will any MP3 player ever catch Apple's iPod?
iRiver is USB 2. Compare:
USB 2 - 480 Mb/s
Firewire - 400 Mb/s
I can synch my iRiver in a couple of seconds. It's definitely faster than my iPod. And much smaller. Possibly cuter. Definitely better for jogging. And I think the headphone quality is better, or at least the same MP3s at the same bitrates sound better from the iRiver then the iPod. I can't compare AAC.
Posted by Oscar on October 8, 2003 at 2:12 PM (CDT)
Will any MP3 player ever catch Apple's iPod?
"Thats the one thing I like about the iPOD is it isn't overclutted with features and is easy to use."
I would gladly have traded an extra quarter inch width on my G3 iPod for a couple more hours battery life. I traded "up" from a G2 and was very saddened by the lack of improvement. I traded up again, this time to a Lyra video player. It's basically the same size as my old G2 iPod, gets twice the battery life for audio, and on top of that I have VIDEO.
Don't dismiss it until you try it! The screen is awesome, clear, and fast, and being able to look at the photos from my Canon straight away is a godsend. The interface is pretty uncluttered, but could use some work.
But then so could the iPod - my wife now has the G3 and being a complete nonuser of Computers has pointed out to me several glaring problems for her in the iPod UI. What I miss on the Lyra is a jogwheel to step back and forward frame by frame through video—now that would be cool!
The feeling I get from the Lyra is like the feeling I got from the G2 back in the day. You know before the iPod when you had all this music, but no way to carry it with you? Except using clunky Walkmans and tapes? And then suddenly it was all there! All the time!
Same deal with the Lyra, except as well as engaging the ears, it engages the eyes. All those photos, movies, video clips, screenshots, you can carry them around, upload, download, transfer. It rules! I don't need VHS tapes or DVDs any more, it's all just in my pocket!
Posted by Lyra on October 8, 2003 at 2:08 PM (CDT)
Will any MP3 player ever catch Apple's iPod?
Well, yes iRiver is USB enabled… it just fine if you have a 128MB iRiver… or "even" with a 512 kb…
but lets get really honest: iPod rocks in design and features, its easy to use, lightning speed transferring GBs of MP3 file through FireWire its vital for this type of marvel… i mean: its awesome!
believe me, if there were something cooler i wouldnt have an iPod… i simply love it!
just give it a try!
Posted by Oscar! on October 8, 2003 at 1:57 PM (CDT)
iPod Adventures in the Middle East: Part I
tslice, such an interesting review with the middle east backdrop and all…hey, ya think i should write an article about traveling with an ipod in the middle of the communist revolution in Nepal? i could get some great shots (literally) standing with a comrade in the himalayas. can ya see it, me with about 12 belkin battery packs chained together and strapped over my shoulder like an ammo belt. Comrade Raj would be looking at me like I was an idiot, and I would be looking at him like don't shoot me man, i'm just the piano player. heck, while i am at it, i might as well be at base camp everest, with a dozen sherpas humping all the ipod accessories i could own if i had a real salary. i really want one of those plexiglass holders for my headphones and all. but that's a weeks pay. oh no, heres one better. me rockin out with dido while riding a packie wearing fubu in the jungle. anyway, good luck man.
get jiggy in nepal.
Posted by jiggy on October 7, 2003 at 1:05 PM (CDT)
iPod Adventures in the Middle East: Part I
I've been humping my iPod all over the place ever since the 'Global War on Terrorism' kicked off. No problems. The LCD screen has issues at below freezing temps that are just a property of the material. Sticking it under my armpit for a few minutes always seems to fix that. If you're going somewhere harsh, I suggest getting a neoprene case for your pod. I had a buddy make one up for me but I'm sure there are commercially avail ones. I haven't had any dust issues or heat problems. The finish is totally wrecked but it still kicks out my BB King when I need it.
Posted by El D on October 5, 2003 at 3:54 AM (CDT)
Switching from MP3 to AAC Without Losing Your Mind
I've tried Apple support a few times and even asked buddies who own several Macs the following question without much help:
Will iTunes for Windows allow me to purchase AAC or MP3 files or both to play on my iPod?
Thanks in advance,
Posted by Lew on October 5, 2003 at 1:24 AM (CDT)
My iPod Buying Experience
Just to let everyone know the knew ITRIPS from GRIFFIN TECHNOLOGIES for the new ipods have finally been released. They e-mailed me to let me know my ITRIP was shipped on Friday. Yeah, can't wait to use it and will let everyone know how it works.
Posted by Jennifer on October 4, 2003 at 2:51 PM (CDT)
iPods for Windows: It's a good thing?
I'm not MAD or rather Mac.
But kudos to Apple for bringing the Ipod to PC users.
I have been a PC user for ages and not ready to switch to MAC anytime or never.
Iadmire Mac designs and stuffs but products tend to be very litmited.
As a PC user, I can upgrade the parts of my PC easily at an affordable rates.
The Ipod is truly the 1st ever product that I buy from Apple. When I learnt that Ipod is catered to PC, I went for it.
Now, I'm enjoying as much as the MAC users.
Even the PC softwares support are almost on par to MAC softwares for Ipod.
Why resent towards PC users ? Afterall, we use the same mouse and keyboard.
Posted by MWang20 on October 4, 2003 at 6:45 AM (CDT)
Switching from MP3 to AAC Without Losing Your Mind
Nero 6 will rip and encode CDs to AAC quickly and easily in Windows. Now if there was just a decent AAC decoder for Winamp…
Posted by RedFive on October 4, 2003 at 4:36 AM (CDT)
My iPod Buying Experience
Just bought the new 40go IPOD
What can I say. Great this is a small toy but why Apple has decided to change the nav system, just to add a nice red color on each button?
This is not so friendly than the first IPOD generation.
I am disappointed about that new product.
Posted by JY on October 3, 2003 at 12:20 PM (CDT)
Will any MP3 player ever catch Apple's iPod?
Yes the iPOD doesn't incorporate these features…but who really wants or uses these features anyway. The iPOD is aimed at a general market where people just want to listen to MP3s on-the-move. And the iPOD does this very well, by meeting its purpose in a compact and stylish way. Thats the one thing I like about the iPOD is it isn't overclutted with features and is easy to use.
Posted by slashjunior on October 3, 2003 at 5:27 AM (CDT)
Will any MP3 player ever catch Apple's iPod?
Yeah. I own 10GB iRiver since the first day they were available here.. Key feaures:
standard USB storage class device, no proprietary crap like Apple or Creative - plug in to any computer with USB, works fine with Linux
you can browse the contents of the drive hierarchically, subdirs and all, no database crap like Creative Nomad Zen or iPod (though you can browse through your mp3 files via a database based on ID3 tags, too)
you can use it to transfer files from one computer to another
HQ Li-Pol battery, 16 hours runtime
nice BIG display, nice display on the remote
you can even read text files on your iRiver while listening to music
iRiver's great customer support - they actually listen to their customers and base their firmware upgrades upon customer suggestions (hence OGG, even when it was very difficult to implement in embedded hardware)
Posted by HappyCamper on September 30, 2003 at 2:27 PM (CDT)
Page 614 of 636 pages ‹ First < 612 613 614 615 616 > Last ›
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text:
Start seated in front of your Partner with your legs spread comfortably wide. Interlock hands with each other. Alternate pulling each other forward to feel the stretch in the hips and hammies. Hold the stretch several counts before switching.
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text:
604 Morris Lane,Wallingford PA, 19086
Sold Price
3 beds , 2 Full/1 Half baths
1,843 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Fox & Roach, REALTORS
(866) 486-5636
Last Updated: 2/22/2017 6:14 PM
Description for 604 Morris Lane Wallingford, PA 19086
This may just be what you have been waiting for... a 3 Bedroom, 2.5 Bath multi-level brick home with attached Garage and a deep back yard in the award-winning Wallingford-Swarthmore School District. You will find attractive hardwood floors in much of the house, a wood-burning stone fireplace and large recently installed bow window in the Living Room. Also on the main floor, there's a brand new patio door in the Dining Room, a renovated Kitchen featuring a gas range, modern appliances, and loads of counter space; both rooms look out on the spacious piece of land. Freshly painted walls and many new light fixtures throughout, this home also provides a recent roof replacement, new siding and gutters, and sewer line installation. The lower level has new carpet in the family room and also offers access to the Garage, Laundry/Utility room and Powder room. The upper level is comprised of a master bedroom with adjoining stall-shower bath, and the remaining two bedrooms share the vintage but serviceable hall Bath. Strath Haven High School was recently recognized as one of among 329 schools nationwide as an Exemplary High Performing School by the National Blue Ribbon Program. Conveniently located near Wallingford Swim and Racquet, Nether Providence Elementary, SpringHaven CC, 476 and 95, Media and Swarthmore. Make an appointment and make this your new home!
Listing Information
Scots Glen
Electric Water Heater, Public Water Service
Public Sewer
School Information
Room Information
Stall Shower
Interior Features
Tile, Vinyl, Carpet, Wood
Central Air
Gas Heat, Forced Air
Bay Window(s)
Exterior / Lot Features
1 Garage Spaces, Attached Garage
Shingle, Pitched
Shed, Open
Financial Considerations
Inside AccessTM
Current market conditions for 604 Morris Lane
Active Market Trends
Source:MLS DATA
Median list price$295,000
Days on market125
Properties for sale39
Sold Market Trends
Source:MLS DATA
Median sold price$287,500
Sales to list price9,617.0%
Properties sold50
Median sq ft price$143
Arrows indicate 90 day trend
Listing Price History for 604 Morris Lane
Wallingford Real Estate
Wallingford is located in Pennsylvania. Wallingford, Pennsylvania 19086 has a population of 11,252.
The median household income in Wallingford, Pennsylvania 19086 is $96,448. The median household income for the surrounding county is $64,242 compared to the national median of $53,046. The median age of people living in Wallingford 19086 is 45.4 years.
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text:
Diner Survey Results 32 responses
"The breakfast menu here is amazing, and incredibly inexpensive. Additionally, the restaurant offers real maple syrup, a real plus for any Vermonter coming here. I would highly recommend this place to anyone."
"fast and friendly "
"Great breakfast, good lunch, and great dinners. "
"Love the hometown cafe in marid rid great food and service "
"Pie was very good "
"It's old fashioned at its best."
"smiling and freindly people along with great desserts and food"
"Minimal vegetarian options, non-breakfast options aren't nearly as amazing"
"New wait staff tend to forget about re-filling your coffee or drinks."
"that i cant get there as much as i would like to"
2 reviews of Hometown Cafe, first by parkhyein.
Okay, so it's a small town diner and the food...
Okay, so it's a small town diner and the food really doesn't deserve five stars. But I can't help it, I freaking love this place (it doesn't hurt that it's MY small town diner). Always filled with old, crabby, overweight people who look at you suspiciously, this is what I'll miss when everything gets replaced by IHOP and Applebee's franchises. Plus, many kinds of pie for $1.75 a slice! Oh, rural living.
HomeTown Cafe- EXCELLENT!!
Come, take a walk with me.
Down to the Night Cafe.
We'll talk and sip our coffee till
night-time turns to day.
We'll walk along cold, ambered streets
before we reach North Main
where through its cafe window see:
folks gathered once again.
See how their faces glow?
As they share the love within.
This place called the Night Cafe:
Folks treat you just like kin.
Come, spend some time with me,
inside the night cafe.
We're wearied with this week of work;
we need a bit of play!
So, come take a walk with me.
down to the Night Cafe!
Let's talk and sip our coffee now,
down in the Night Cafe.
copyright 2014 ZBM
Dishes Tried:
Ham and Chees Omlett
This place has the BEST omletts in the world! Somebody really knows how to cook! Absolutely mouth-watering, and very easy on the eyes too. If you haven't tried this breakfast delight…hurry! Your eggs will get cold!
Best Dishes at Hometown Cafe
These dishes from the Hometown Cafe menu are contributed by Menuism users directly, as part of a restaurant review, or as part of an image upload.
Ham and Chees Omlett ()
- Tags
- Website
Loves Hometown Cafe (1)
Recent Visitors
2/08/2017 A diner from US tried it.
1/28/2017 A diner from Sugar Grove, OH tried it, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
1/10/2017 A diner from Ogdensburg, NY tried it.
12/11/2016 A diner from Canton, NY tried it.
9/06/2016 A diner from Schenectady, NY tried it, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
7/24/2016 A diner from Potsdam, NY tried it, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
- Pros
- Lots of food fast and inexpensive
- Cons
- Hard to get a seat after 9am on a Sunday
6/23/2016 A diner from Oswego, NY tried it, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
5/25/2016 A diner from Potsdam, NY tried it.
4/25/2016 A diner from Massena, NY tried it and liked it.
4/08/2016 A diner from New York, NY tried it.


text:
Western House, Hertfordshire calendar of events
March 2017
London Festival of Railway Modelling
March 25th - 26th 2017 | Alexandra Palace, London
Held at London's Alexandra Palace, the London Festival of Railway Modelling is a large exhibition aimed specifically at model railway enthusiasts.More information...
April 2017
Country Living Spring Fair
April 27th - 30th 2017 | Alexandra Palace Way, London
The Country Living Spring Fair has everything you need to brighten your home this spring. Enjoy a break away, book accommodation today!More information...
May 2017
Festival of Living Crafts, Art Design & Innovation
May 4th - 7th 2017 | Hatfield House, Hertfordshire
The Festival of Living Crafts, Art Design & Innovation is back in 2017 from the 4th to the 7th May. Book accommodation with Eventful Stays!More information...
July 2017
Wireless Festival
July 1st - 31st 2017 | Finsbury Park, London
One of London's most popular daytime festivals, Wireless has showcased top international music stars in the capital's main public parks since 2005.More information...
August 2017
Athletics World Championships
August 5th - 13th 2017 | Olympic Stadium, London
The best athletes in the world come together for the Athletics World Championships at the Olympic Stadium.More information...
London Super Comic Convention
August 25th - 27th 2017 | Business Design Centre, London
The London Super Comic Convention is a large event focusing on anything and everything related to comics! It attracts creators from Europe & the USA.More information...
September 2017
Parallel London
3rd September 2017 | Queen Elizabeth Olympic Park, London
Parallel London, held at the Queen Elizabeth Olympic Park in East London is a pioneering all-inclusive run led by those with disabilities.More information...
November 2017
Winterville London
25th November - 23rd December 2017 | Victoria Park, London
Winterville, Ireland's largest Christmas festival is here; Styled as a town, it is free to enter although, there's a charge for many attractions.More information...
February 2018
National Gay Wedding Show
February 24th - 25th 2018 | Holiday Inn, Camden Lock
The National Gay Wedding Show is an annual event held in the UK that offers an alternative to the traditional bridal fairsMore information...


text:
Spoiled Brat Boot Camp
Who is ready for a radical new idea?! I am about to present new ideas about a cherished tradition, new even to myself.
This excerpt comes from my notes as I utilized the wonderful creation that is a smart phone and emailed myself a quick note while at a
birthday party for toddler-aged kids. (I know, I know, I should have been totally focused on the festivities. Please forgive me.)
"I am witnessing a rather blatant exercise in entitlement training. I am currently standing on the proving grounds of 'How to Develop a Spoiled Brat'. Where am I, one may ask. At a birthday party for a 5 year old and a two year old (combined party). Family and friends encircle the room. All presents piled are high in one corner. The child is plopped in the middle of the room and the material worship begins. How much better if each person held their plastic-laden, battery-powered, migraine-producing (unless of course someone actually got the lad a BOOK or other learning device) offering in hand. Before handing it over as though they owed this little being something, offer an explanation of love and encouragement and what that child means in the life of the giver."
First of all, I am NOT trying to rain on a wonderful parade or be the party pooper. At the same time I cannot ignore the obvious behaviors displayed at nearly all these gatherings. Child demands another gift, grabs the card only to fling it like a missile, tears through the $5/roll wrapping, peeks at the plastic mold that he/she just had to have, throws it aside, and repeats process. Wow. I almost called myself a prude after all that. Stay with me here.
Try This!
I am not against birthday parties or anything of the like. Heck, I LOVE 'em! I am simply cautioning against producing this entitlement mentality that is absolutely rampant across America. That's all. My wife and I still have all the fun stuff for the kids and spoil them a little bit (mostly for me). I'm simply saying we should be careful and take time to explain to our children why we give gifts and spread generosity.
Take a mental walk with me. Close your eyes...never mind, I forgot you're reading. Anyway, imagine the consequences!! Or should I say...RAMIFICATIONS. The ripple effect of instilling these values into our children could REVOLUTIONIZE our great country. Can you picture a generation of kids who grew up to be young adults who RESPECTED OTHERS and themselves?!
I'm sure we can all agree our nation casts a much different shadow than it did as recently as a generation ago. It would take countless hubs to discuss it all and frankly, I don't have all the answers to our collective ills. I like the quote, "If I had a simple answer I'd be a politician." No offense intended, I just thought it was funny…and true! I do know that our nation has drifted so far from the mainland that was 1776 that we can barely see the shore, if at all.
However! If we started adjusting the way we develop thinking in our kids (and ourselves) with good ole traditions like gift-giving, I truly believe we are on our way to brightening the WORLD!
More by this Author
Comments 2 comments
I agree man. So many children do not place value on what they hav and extra they receive. Very sad.


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Designed for the youngest of fans. Mega Power Iron Man is ready to soar in to action. Loaded with lights and sounds his jet booster pack features popout wings.
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text:
Everything You Think You Know About Politics...and Why You're Wrong
By (author) Kathleen Hall Jamieson
Format: Paperback
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Everything You Think You Know About Politics...and Why You're Wrong by Kathleen Hall Jamieson
Book DescriptionHere, at last, is the book for anyone who ever wondered how the media extravaganzas we call political campaigns really work. Everything You Think You Know About Politics...and Why You're Wrong explores why the American public, seemingly so eager for "unspun" information about candidates and their positions, invariably ends up feeling manipulated by our political process.Challenging the reader with strategically placed quizzes, well-known commentator on the media and politics Kathleen Hall Jamieson surveys the existing public record on voting patterns, campaign promises, and all manner of electioneering and comes up with an engaging mix of analysis, surprising factoids, and political cartoons. This book separates the facts from the convenient fictions that deter Americans from caring about the processes and outcomes of elections.
Buy Everything You Think You Know About Politics...and Why You're Wrong book by Kathleen Hall Jamieson from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780465036271
(229mm x 152mm x 19mm)
Pages: 320
Imprint: Basic Books
Publisher: The Perseus Books Group
Publish Date: 2-Jun-2000
Country of Publication: United States
Other Editions...
Books By Author Kathleen Hall Jamieson
Presidents Creating the Presidency, Paperback (April 2008)
Arguing that the presidency is not defined by the Constitution - but by what presidents say and how they say it, "Deeds Done in Words" has been the definitive book on presidential rhetoric. This title reveals how our media-saturated age has transformed the rhetorical strategies presidents use to increase and sustain the executive branch's powers.
Institutions of American Democracy, Paperback (April 2006)
A collection of essays by the nation's leading journalism scholars and professionals will examine the history, identity, roles, and future of the American press, with an emphasis on topics of concern to both practitioners and consumers of American media.
2000 Presidential Election and the Foundations of Party Politics, Paperback (July 2004)» View all books by Kathleen Hall Jamieson
An examination of the US electoral process, providing an integrated account of the 2000 campaign.
» Have you read this book? We'd like to know what you think about it - write a review about Everything You Think You Know About Politics...and Why You're Wrong book by Kathleen Hall Jamieson and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Kathleen Hall Jamieson
A nationally renowned expert on presidential politics, Kathleen Hall Jamieson is Dean of the Annenberg School for Communication and Director of the Annenberg Public Policy Center, University of Pennsylvania. She is the author of several widely acclaimed books on American politics and is herself a frequent media commentator on "CBS News," "Weekend Edition," and "CNN's Inside Politics." She lives in Philadelphia, Pennsylvania.
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1. With record deportations ongoing and immigration reform once again being called a longshot, family and clergy members confronted Homeland Security head Jeh Johnson Wednesday.
2. Naira Zapata, the fiancé of Ardani Rosales, who was deported after a traffic violation, broke down crying in front of Johnson.
3. "She started crying to him, 'Can you please release my husband?'" said DREAMer and activist, Erika Andiola.
Andiola said Johnson said "I'm sorry and I understand," to Zapata and looked at her children.
4. The actions were put together by Church World Service and PICO, a national network of faith-based community organizations, that delivered a letter to him signed by 1,000 clergy members of different faiths.
5. The letter calls for "an immediate end to the senseless separation of American families."
6. As well as for expanded deferred action for those who would benefit from immigration legislation.
7. Clergy leaders commented on why they believe immigration reform is the right thing to do according to their faith.
8. "I stand here today because I am a Jew. To be a Jew is to take on a sacred task: To remember that we were once strangers in a strange land and to treat citizen and stranger alike," Rabbi Esther L. Lederman said.
"This policy of deportations is destroying the bedrock of what makes our congregations and society strong – our families. Our synagogues and churches are made up of families, moms and dads doing the best that they can to raise righteous citizens, decent human beings," she added.
9. "The truth is, African-Americans didn't come here, we were brought here, by a system that dehumanizes and exploits for profit. Today we see our brothers and sisters — undocumented workers — are kept in the shadows, and exploited for cheap labor."
This was said by Rev. Dr. Earl Trent, the chair of Church World Service, who also took on the controversial Secure Communities program that gets the finger prints of people who are apprehended. "Secretary Jeh Johnson says that the Administration wants to fix Secure Communities, but this program is too broken to be fixed, it is beyond repair," he said. "We can't MEND S-Com, so we must END S-Com."
10. Nayelly Sandoval, 12, said she wrote a letter to President Obama but received a response that didn't make sense.
11. "A few weeks ago I got his response," she said. "It wasn't even about my family. It just said, 'Dear student' and had some general stuff about the White House. I don't want pictures of his dogs. I want my dad back."
12. Andiola said the day's events are useful because it's "a good way for him to understand there is a human cost to all of this."
13. Andiola said House Majority leader Eric Cantor's loss to an anti-immigration tea partier changed the calculations.
"Immigration reform is dead for now, so the best thing to do is to get the president to act," she said.
14. Specifically her group of DREAMers has been calling for two things.
"Enforcement reforms" like changing who is a priority to detain and "administrative relief that would expand deferred action," which would create a new group that is protected from the threat of deportation.
15. "The clergy firmly believe the president has a moral obligation to stop deportations and that he must act to end the suffering of the undocumented," said Rich Morales, the deportation prevention coordinator at PICO.
- The Trump administration wants to send immigrants caught at the southern US border to Mexico even if they're not from the country.
- Several states will keep enforcing bans against transgender discrimination in schools after Trump withdrew guidelines protecting students.
- Police arrested at least 10 people on Wednesday as they began clearing out protester camps at the Dakota Access Pipeline site.
- And people with disabilities are having their photos stolen and Facebook isn't helping them.


text:
From: firstname.lastname@example.com
We have a lot of new members here, all of whom are most welcome, and I think
it is
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Auto Global Equipments
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Quick Lock Nut For Wheel Balancing Machine
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Sarveshwari Engineers
355, Deepali, Pitampura, Delhi 110034, Delhi - 110034, India
Deals in exhaust gas analysers, WHEEL ALIGNMENT, wheel balancers, diesel smoke meters
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Use the mouse to move!
The first goal of this game is to eat everything you can!
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eBook (PDF), 160 Pages
Price: $9.99
The United States is not the only country in the world with obesity issues but for some strange reasons obesity in America is far more severe than in any other part of the world. There is something very mysterious about characteristics of American made obesity. Forget about the fact that we eat too much, forget about the complexity and artificiality of our food. For some unexplained reason we, Americans seem to be proud to be overweight. I was puzzled by this phenomenon for years, then, one terrifying Halloween night, blinded by the movie projector light I had a vision. At that dim wrinkle in time, I realize that we all live in a culinary American dream created by the Masters of Advertising. An imaginary world sponsored by the greedy Calorie Corporations. A lifelong commercial with the endless supply of the best looking, the best tasting and the healthiest food in the world, the illusion that I call – The Fat Matrix :)
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CHICAGO (MarketWatch) — Among the companies whose shares are expected to see active trade in Wednesday's session are Apple Inc., American Express Co. and Abbott Laboratories.
After Tuesday's closing bell, Apple AAPL, +0.30% reported a big jump in fiscal third quarter earnings Tuesday, zipping past Wall Street's estimates and raking in nearly $25 billion in sales. Shares jumped 7% to break $400 in after-hours activity. For the quarter ended June 25, Apple earned $7.31 billion, or $7.79 a share, up from $3.25 billion, or $3.51 a share, for the same period a year ago. Revenue jumped 82% to $28.6 billion for the quarter. Read more on Apple earnings.
digits: The Best Times to Buy Apple Products
Apple rarely offers sales, so cutting prices even a little bit is online retailers' best chance of luring customers in. Kelli Grant tells us how long customers should wait after new Apple products come out in order to snag a deal.
American Express AXP, -0.14% with its quarterly numbers on tap for after the close Wednesday, is expected to earn 98 cents a share with revenue of $7.34 billion.
Abbott ABT, +0.00% is set to report its second quarter profit before the opening bell. The pharmaceutical firm is expected to earn $1.11 a share on revenue of $9.54 billion, according to the average estimate of analysts polled by FactSet Research.
Ebay EBAY, -0.29% and Intel INTC, -1.23% report after the close. Analysts see the online auctioneer earning 46 cents a share on revenue of $2.6 billion while the chip giant is seen pulling down 51 cents a share with revenue of $12.8 billion.
Other big firms scheduled to roll out their numbers Wednesday include Johnson Controls JCI, -1.08% Altria Group MO, -0.07% and United Technologies UTX, +0.14% .
Watch list
Chipotle Mexican Grill CMG, -1.10% could be on the griddle. Shares of the restaurant chain fell almost 4% in after-hours action Tuesday when its second quarter profit came up shy of Wall Street expectations, although it handily beat estimates on the top line. Read more on Chipolte earnings.
Yahoo YHOO, +1.05% is also set to lose a few points. It was off almost 2% Tuesday evening after it reported a second quarter profit of $237 million, or 18 cents a share, up from $213 million, or 15 cents a share in the same quarter last year. While it met Wall Street's targets, the company's revenue slipped 5% to $1.1 billion. Read more on Yahoo.


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The legacy of the beloved "Mister Rogers" lives on with the hit television series, Daniel Tiger's Neighborhood. Now, Daniel and all of his friends are hopping aboard Trolley to delight live audiences with DANIEL TIGER'S NEIGHBORHOOD LIVE!
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On Second Thought is a one-hour, daily news talk show that airs at 9 a.m. ET weekdays.
Host Sharon Collins talks to some of the many disabled individuals who have been able to find happiness and confidence through a connection to nature. Thursday, February 23 at 8:30 PM
The GHSA state championships for football are right around the corner. There are 16 teams left on the road to the Georgia Dome and by late Saturday night all eight champions for 2016 will be... MORE
GPB Passport is the new member benefit that provides you with extended access to an on-demand library of quality local and national public television programming, including tens of thousands of hours of your favorite programs.
Thu., April 14, 2011 12:28pm
Savannah Film 'Conspirator' Opens
A Savannah-shot film gets its national debut this weekend. Robert Redford's "The Conspirator" tells the story of the lone woman charged in President Abraham Lincoln's assassination. Savannah stands in for Civil War era Washington D.C. and gets a lot of screen time. So do extras like Philip Aultman, who appears about a dozen times.
Full Story
Thu., November 18, 2010 5:27pm
Savannah Considers Cutting Film Office
Savannah city officials are considering cutting their film office budget. The move is aimed at closing a gap in revenues and spending. But it's striking some in the film industry as short-sighted. The city recently hosted two high-profile movies that brough the area millions of dollars.
Mon., March 8, 2010 12:31pm
Georgia Ramps Up Film Production
One area of Georgia's economy is taking off.
Fri., September 11, 2009 1:17pm
Redford To Return To Savannah
The movie director will shoot a Civil War film in the city where he shot "T


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epicplayer did sometihng like a custom map maker is that working?
probably not never seen him realise something he only says he will
it was FAAAAAAAAAAAKEEEEEEEEEEEEEE =D
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36th Annual Macy's 4th of July Fireworks
Wednesday, June 27, 2012 at 4 a.m.
Leave the fireworks to the experts and experience the thrill of 40,000 of them going off above your head at the 36th Annual Macy's 4th of July Fireworks. With live performances by Katy Perry and Kenny Chesney. Best views on 12...


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CANTON - North Hall certainly isn't going to win all of its football games. But the Trojans certainly find a way to win the ones that count.
CANTON - North Hall certainly isn't going to win all of its football games. But the Trojans certainly find a way to win the ones that count.
CUMMING - West Forsyth got off to a slow start Friday, but once the ball started rolling, the Wolverines quickly removed all doubt.
CUMMING - West Forsyth got off to a slow start Friday, but once the ball started rolling, the Wolverines quickly removed all doubt.
MADISON – The Jackson County football team fell a win short of the best start in school history after suffering its first loss of the season Friday at Morgan County, 14-7.
OAKWOOD - The top-ranked Gainesville Red Elephants have increased their point total every week, and on Friday against West Hall, they nearly equaled their season-high total of 55 points in the first half.
In this business we're not supposed to care about who wins or loses. We're there to cover the games, tell readers what happened, and write about the players and coaches the community cares about. The scoreboard isn't supposed to be a concern for us, and most of the time that's the way it works.
If one was to make the argument that North Hall's football team has played the toughest schedule in the state to this point in the season, it probably wouldn't be met with too much debate.
Banks at North Oconee
Region 6-AA's No. 1 ranked Wolves' softball team came back from a loss Wednesday to defeat Westminster 10-1 in five innings Thursday in Atlanta.
Even in his finest moment, you're not going to get Ty McCormack to say anything overly confident about an individual accomplishment. Honestly all he cares about is how his North Hall team finishes.
JEFFERSON - Lucas Redd typifies what is right with the Jefferson offense this season. Redd, a fullback for the eighth-ranked Dragons (4-0, 3-0 Region 8-AA), has seven touchdowns this season, which is pretty accomplished for a blocking back.
At the end of Week 4 Gainesville, Hall County's best team in my opinion, seem to be improving each week.
Class AA's No. 1-ranked Buford softball team saw its nine-game win streak come to an end in a 3-1 loss to Marist on Thursday in Buford.
JEFFERSON - Jefferson Dragons wrestling coach Doug Thurmond has earned his share of accolades over his more than 20 years in the sport.
The West Hall volleyball team continued its six-match win streak, coming back from a 0-4 record in the region, defeating rival North Hall (25-23, 17-25, 25-13) and East Hall (25-12, 25-17) on Tuesday in Gainesville.
The rainy weather that has wreaked havoc in Georgia over the last week has also caused the high school softball season to come to standstill.
Page 301 of 430
The Flowery Branch girls tennis team swept Jefferson 5-0 on Monday.
The East Hall boys basketball team survived a back-and-forth game against Greater Atlanta Christian to capture a 67-61 victory and the Region 7-AAA championship Saturday ...
Christen Copeland picked a good season to focus on her free throws.
Bryan Richerson spotted something in the rafters when he recently took stock of the West Hall High gym.
Christen Copeland was already quite familiar with Lakeview Academy's Region 8-A semifinal opponent.
Entering Friday's Region 7-AAAA tournament semifinal, the Chestatee girls basketball team hadn't played in 10 days.
Taylor Hawks poured in 18 points for the Gainesville High girls as they topped Dacula 49-40 in the Region 8-AAAAAA semifinals on Friday at Apalachee ...
The Flowery Branch girls tennis team dropped just one set in a season-opening 5-0 win against Lanier on Thursday.
It comes to no surprise the status quo remains a constant for the top-seeded Gainesville boys basketball team.
Julianne Sutton scored her 1,000th career point as the Flowery Branch girls basketball team beat Johnson 69-10 in the first round of the Region ...
By coach Jeff Steele's estimation, free-throw shooting cost his Lumpkin County boys basketball team seven wins this season.
Running, lifting, drills and grappling are some of the things area wrestlers have done to make it to the Traditional Wrestling State Tournament set for ...
For the first half of Tuesday night's contest against Riverside Military, the Lakeview Academy boys basketball team lived up to its No. 1 billing ...
The Flowery Branch Boys basketball team advanced to the second round of the Region 8-AAAAA tournament by knocking off Clarke Central 65-42 at Cedar Shoals.
David Sokol has experienced the harsh realities of first-round region tournament games.
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Neptune Sheldrake Upholstered Dining Chair, Elliot
Product information
The perfect dining chair for beautiful, restrained luxury. Expertly crafted from North American White Oak, this fully upholstered chair features clean, crisp linen in a warm hue, and elegant button detail for a bespoke appeal.
Finished with a slim shape, this timeless piece looks wonderful when paired with our Sheldrake Tables.
Please note: Not all of our ranges are on display in our furniture departments. Please callyour nearest John Lewisto check before you visit.
0% APR Representative: If you buy this product in our shops, it's eligible for Interest Free Credit, which is available when you spend £1000 or more on selected home products. Terms and conditions apply: find out more
- Assembly Required
- Fully assembled
- Brand
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- H98 x W46 x D62cm
- Eligible for International Delivery
- Furniture Range
- Sheldrake
- Height of seat
- 48cm
- Material
- North American White Oak, Wool
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- 10kg
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Confirmatory Factor Analysis. a priori measurement model is specified and testedfactor loadings direct relations between observed and latent variables are modelederror terms are the leftovers"estimate the variance of these thingsfactor variances/covariancestypically we are interested in the standardized covariances between factorsfactor correlations.
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1. Confirmatory Factor Analysis (CFA) CFA is used when strong theory and/or when a strong empirical base is available
Specify relations a priori
number of factors
relations among factors (i.e., correlated vs. uncorrelated)
variables specified as fixed or free on a respective factor(s)
2. Confirmatory Factor Analysis a priori measurement model is specified and tested
factor loadings
direct relations between observed and latent variables are modeled
error terms are the �leftovers�
estimate the variance of these things
factor variances/covariances
typically we are interested in the standardized covariances between factors
factor correlations
3. Two-factor correlated CFA model
4. The Process Specifying the pattern matrix:
* = parameter we will estimated (free)
0 = parameter noted estimated (fixed)
5. The Process Model specification via the Bentler-Weeks model
all variables in a model are categorized as IVs or DVs
DV = variable with unidirectional arrows aiming at it
want to explain the variance in these variables with other variables (IVs)
e.g., our eight observed variables
IV = no unidirectional arrows aiming at it
but there can be an unanalyzed association
mathematically we estimate the error variances from slide 3 as well
6. The Process you write an equation for each DV
S1 = ?(Academic Self-Esteem) + e1
S2 = ?(Academic Self-Esteem) + e2
S5 = ?(Relationship Self-Esteem) + e5
S6 = ?(Relationship Self-Esteem) + e6
? represents a regression coefficient (factor loading)
e represents error (or residual), this path is not directly estimated (fixed)
predetermined by the factor loading
7. The Process core parameters in CFA are these factor loadings and variances/covariances for IVS
notice that the latter are not directly specified in these equations
e.g., covariance between Academic and Relationship Self-Esteem
they are a function of the equations that you see
via some complicated matrix algebra
however, you must specify them to solve the equations
software does this for us
8. The Process Estimating the model
using primarily maximum likelihood
estimation produces a fit function
Determination of model fit
done at two levels
overall model fit
individual parameter fit
parameters = generally factor loadings in CFA
but include factor covariances (correlations) if specified
9. The Process Overall model fit (Goodness of fit)
tells us if the model should be accepted or rejected
if model is accepted, interpret model parameters
if model is rejected, do not interpret model parameters
Determining goodness of fit
test statistic
?2 provides a statistical test of fit
?2 = ( fit function ) ( N � 1)
we want this to be nonsignificant
10. The Process types of descriptive indices
absolute fit indices
indexes the amount of variance/covariance accounted for by a model
goodness of fit index (GFI) and adjusted GFI
want values > .90
root mean square residual (RMSR)
average size of residuals generated by a model
want standardized values < .05 if model is good
11. The Process comparative fit indices (CFI)
compare target model to a baseline model
baseline model = null or independence model
null model = specifies no factors
CFI values > .90 are good, .93 better, .95 great
parsimony adjusted fit indices
adjusts fit by weighting values by the number of parameters estimated
root mean square error of approximation (RMSEA) is best
values less than .08 are good, .05 are better
12. The Process Fit of individual parameters
we have statistical tests for each factor loading and each factor co(variance)
evaluate the critical ratios (CR)
these are distributed as z-values
What if my model and/or individual parameters do not fit?
report that and stop, or
go to the model modification phase
the LaGrange Multiplier test
the Wald test
13. Practical Issues Identification
also needed to mathematically solve the equations
based largely on degrees of freedom (df) for the model
df = nonredundant elements in ? - parameters estimated
elements in ? = # variances & covariances
this equals p (p+1) / 2, where p = # observed variables
parameters estimated
count up factor loadings, factor covariances, and IV variances estimated
14. Identification of a one-factor model e.g., 4 MVs ? 4 (4 + 1) /2 = 10 variances/covariances
e.g., 4 factor loadings, 4 error variances
e.g., df = 10 � 8 = 2
15. Practical Issues over-identified (the ideal)
positive df = more information than parameters to estimate
can determine overall model fit
too many parameters, not enough information
model cannot be estimated
just-identified (df = 0)
parameters to be estimated = amount of information
no overall model fit, but you can interpret parameter estimates
16. Practical Issues EQS will present unstandardized factor loadings and factor covariances
remember, the analyses are based on ?
however, we generally interpret standardized solutions
this makes factor loadings range (roughly) between 1 and �1
and makes factor covariances into factor correlations
17. The Structural Model Testing the directional relations among latent variables
This is just path analysis with latent variables
Latent variables are developed through confirmatory factor analysis (CFA)
General modeling process is the same as with CFA
18. Structural Model Equations
19. Comparing nested models
20. Comparing nested models
21. Comparing nested models we can statistically compare models 1 and 2
model 1: does not have the direct effect
model 2: does have the direct effect
both models have the mediated or indirect effect
model 1, then, is nested within model 2, and thus they can be statistically compared
we do this using the ?2 difference test (? ?2 )
22. ?2 Difference Test Statistically compares nested models
nested = lower-order models that contain a subset of the parameters from a target higher-order model
e.g., model 1 is nested within model 2 (target)
??2 = ? 2nested - ? 2target; ?df = dfnested � dftarget
notice that the nested model will always
have worse overall model fit (higher ?2 )
and more degrees of freedom
because we are estimating fewer things
??2 and ?df will always be positive because of this
23. ?2 Difference Test if ? ?2 is not significant...
there is no difference between models
the simpler or more parsimonious model fits "better"
if ? ?2 is significant...
target model fits better and...
24. Comparing nonnested models This is a direct comparison between models that have at least a subset of variables that differ
We typically use other descriptive fit indices for these purposes
Akaike Information Criterion (AIC)
Bayesian Information Criterion (BIC)
Expected Cross-Validation Index (ECVI)
For all of the above indices, the model with the smaller index value is the better-fitting model
25. Setting the Scale (Metric) for an Endogenous Latent Variable We need to do this to mathematically solve the equations of the model
Two options:
fix variance of latent variable to 1 (standardize)
fix a factor loading for each LV to 1
For an endogenous LV, you can only use the second option
we want to predict the variance of the endogenous LV
setting this value to 1 does not allow for this possibility


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Ore. man stunned family feared he was Gacy victimOre. man surprised to hear family feared he was Gacy victim after he ran away 35 years ago
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I can understand how this would be upsetting you. It seems things were said in the heat of the moment...these things happen.
I would probably wait a week or so and then send a text and say something along the lines of 'im so sorry fr your loss and im very sorry for our last conversation.
Try not to beat yourself up too much.