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Valoraciones de huéspedes
Valoración general
las habitaciones estaban limpias."
el personal le pareció muy amable."
las habitaciones estaban limpias."
Valoraciones recientes
- Todas las valoraciones
- Positivas
- Neutrales
- Negativas
5.0valoración de
The Staff were great and the complimentary breakfast was well done. The rooms were not as advertized. The whirlpool bath was the size of an ice chest and the water temperature was uncontrolable. It literally took 39 minutes to fill up a 10 gallon bath tub.
9.0valoración de
Excellent location, price and friendly staff. I needed my comforter replaced after our second night due to an accident my daughter had. I gave the soiled one to the maid and told her my room number. When we returned later that night the comforter was not replaced


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Mixed Parts Edition SMD5 (previous headsup) is currently available to order online here, with this timed release ending September 6th. And while no specific quantities been set for this vinyl, know that the "first batch" was reported as snapped up, but pre-orders are still open for now.
Priced t US$85 per, SMD5 stands approximately 23cm tall, and features 5 x points of articulation (SMD5 Reviewed) and includes header card and polybag designed by Jeff Lamm.
Unbox Industries as well states that they "cannot ship requested colour breaks" as "mixed parts will be randomly mixed."

subset: commoncrawl


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Ad network Halogen Media is merging with YouCast, a social media and ad technology firm, in hopes of adding a little earned-media firepower to its luxury-focused advertising business.
"There are many people trying to figure out how to 'do social' successfully, consistently, and at scale," said Greg Shove, CEO of Halogen, in a blog post. "Halogen has great paid media expertise. YouCast knows earned media, and has the technology solutions in place to prove it."
Terms of the deal were not disclosed. The two companies are referring to it as a merger, though YouCast, which is based in New York, will become a wholly owned subsidiary of Halogen.
Halogen, which is based in San Francisco but also has offices in New York and Los Angeles, delivers ads from high-end advertisers like BMW, Mercedes, Neiman Marcus, and American Express to "tastemaker" publishers like GuestofaGuest.com, Fashionista.com, and JamieOliver.com.
YouCast's "earned media" model is centered on pushing campaign messages through thousands of publishers that act as independent, though incentivized, advocates. Bringing the two approaches under one roof will provide scalability and better measurement for clients.
"John [Eaton] and I have always been passionate about bringing the quality and precision of paid media analytics – from search metrics, to CTRs, to reach and frequency – to the earned media channel," said Jonathan Cohen, YouCast's chairman and chief development officer, in the blog post, referring to YouCast's president. "We've already had some success at measuring the effectiveness of various social media efforts for clients, but this merger helps us (and Halogen) do it on a much higher level."
YouCast clients include Pepsi, Macy's, and Novartis. The companies claim there are no conflicts between the two client lists. YouCast co-founders Eaton and Cohen will remain in their current roles, and no layoffs or office closures are expected.
Related reading
President Trump is a savvy domain name buyer
President Trump's digital savvy isn't limited to social media. As it turns out, the Trump Organization owns thousands of domain names, possibly even more than 10,000.
How brands can use social media analytics in 2017
Social media has developed into an effective component of digital strategy, but measuring its performance is still a challenge. How will analytics affect social media in 2017?
Five ways President Trump takes advantage of social media
I didn't vote for him last November. There was no way this registered Democrat from the blue state of Massachusetts would check that box. But I have to give him props for his tweets.
Is Twitter slowly dying?
On Thursday, Twitter reported its earnings for Q4 2016, and the results have raised questions about the company's long-term future.


text:
Model: DC390K
Heavy-Duty 6-1/2'' 18V Cordless Circular Saw Kit
$335.99 $217.99
Free Shipping Over $49Details
*Free Ground Shipping on orders $49 or more!
Orders less than $49, we charge a flat fee of $6.95 to the Continental US only. All other locations outside of the Continental US will receive discounted rates.
Heavy-Duty 6-1/2'' 18V Cordless Circular Saw Kit
- Powered by the DEWALT 18V "system" of battery packs.
- 6-1/2'' blade cuts 2X materials (ex. 2x4) at 45 degrees in a single pass.
- Left side blade provides maximum visibility to the cut line.
- 50 degree bevel provides additional capacity for specialty applications.
- DEWALT-built high-performance motor with fan cooling delivers maximum power and durability.
- Spindle lock for easy blade changes.
- Replaceable brushes for longer motor life.
- Heavy - duty kit box provides protection and transport for the saw.
What's in The Box
- DW9116 one hour charger with Automatic Tune-Up™ Mode
- (1) 18V XRP™ battery pack.
- 16 tooth carbide saw blade
- Blade wrench
- Heavy-duty kit box
- Owner's Manual
- 30 Day Satisfaction Guarantee
|Model DC390K
|Brand DeWALT
|Adjustable 2.4 Ah
|Amperage (amps) 10 Amps
|Arbor Size 5/8 in.
|Battery Power Type Ni-Cad
|Bevel Capacity 0 - 50 Degrees
|Bits Blades & Abrasives Type Saw
|Blade Diameter 6 1/2 in.
|Certifications and Listings UL Listed, CSA Listed
|Chain tension adjustment Yes
|Charge time (hours) 1 hour
|Clutch Yes
|Cordless / Corded Cordless
|Depth Adjustment No
|Drive System Hypoid Geared
|Electrical brake Yes
|Length Of Stroke 1.65 in.
|Maximum Cut Depth @ 45 Deg. 2.25 in.
|Maximum Cutting Depth (in) 2-1/4 in.
|Maximum Speed (rpm) 3,700 rpm
|Motor Type Electric
|Orbital Action Yes
|Oscillations Per Minute (OPM) 1
|Pad Size Glass Filled Nylon (housing)
|Rotations Per Minute (Rpm) 3700
|Saw Blade Diameter (in) 6
|Side Handle Yes
|Voltage (volts) 18V
Heavy-Duty 6-1/2'' 18V Cordless Circular Saw Kit is rated out of 5 by 1.
Rated 5 out of 5 by Toolfan from 18 v saw very handy saw!!!
Date published: 2012-05-19


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I just got a good listen on these headphones at a friends and thought I'd share my quick thoughts just in case anyone is interested in a vintage pair of ortho headphones. I did this listening while going back and forth between the YH-1 and my HE-500s. I've heard of these going for $60, but I only found a couple in the $100-$150 range. As far as I could tell there was nothing wrong with the pair I was listening to, but becuase of the age I wouldn't be surprised if not all YH-1s sounded the exact same.
Source was iPod5.5g LOD to Fiio E11
Build + Comfort
Dang these things are light. They're lighter than many of the good headphones out there, but still have the orthodynamic technology. They pull this off by having almost a non-existent (weight wise) headband. The build quality doesn't feel super-sturdy, but they have survived over 30 years, so that's a good sign. They are on-ear, but there is so little clamp that I didn't find them at all uncomfortable. Because of the small amount of clamp, I wouldn't want to use them while moving around much as they would probably fall off my small head.
My first thought was, "these things sound great!" They had a nice smooth presentation with beautiful mids and plenty of bass. The quick is that this has a "\" shaped response, so above flat bass, and reduced highs. These cans have a good sound, but certainly are not flat.
As I listened on, I noticed a lack of treble. The treble is there, and I could still hear every instrument without issue, but the micro detail wasn't present. Since the treble is recessed a bit, certain instruments that have their detail or texture in the highs (snare drum, trumpets, etc.) sounded a bit off. This issue isn't a deal breaker at the price point, but if you like bright or sparkly or detailed headphones than these are not for you.
The mids are just wonderful and sort of lull you to sleep becuase they are smooth and keep the focus of the music in the place we naturally want to focus. While comparing these to the HE-500, I noticed that the texture of the instruments and voices were lacking (I think due to the recessed highs). I think this acts to make the music more relaxing and soothing. In short, good mids.
The YH-1 has a surprising amount of bass. If you're a bass head this is a can to consider. I found the sound similar to a "bass boost" feature on some amps. I actually had to double check that the bass boost wasn't activated on my fiio E11. And, just like the EQ effect, this sounds great on some music that is mastered without much bass, but is overkill on already bass heavy music.
YH-1 vs. HE-500
These are obviously in different pricing categories, with the HE-500s being 4-7 times more expensive, but the comparison will at least tie the YH-1 to a more well known pair of headphones. So, the YH-1 certainly doesn't match up well. The 500 has great bass, great mids, and great treble, while the YH-1 is about the bass and mids. The texture and timbre is much more lifelike on the 500 as well. The YH-1 does have more bass than the HE-500 and "smoother" mids, but the lack of detail is the cost.
I wouldn't consider these if you're looking for something balanced or as your only headphones, unless you are a serious bass head. However, if you want to get an extra pair of headphones to compliment some balanced or bright cans then I would seriously consider these, especially if you are interested in vintage or orthodynamic headphones. After writing this all down it seems like these aren't very good cans, but they did have a good sound. For me personally, the low treble and extra bass just doesn't work well (I prefer too much treble to too much bass).
Well, hopefully this helps someone.


text:
Licensed Mortgage Professional
(480) 206-6516
17015 N Scottsdale Road, Suite
Scottsdale, AZ 85255
Welcome to Cherry Creek Mortgage Scottsdale
Superior Service
"Over the past eight years, I have had the opportunity to work
with Alisa Glutz and both my clients and I have found her to be of
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successful real estate broker, it is necessary to be able to refer
a lender whose character and competence is beyond reproach. Thank
you Alisa for giving me this peace of mind! Alisa is the consummate
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ever known, and she's someone you want in your corner."
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- Sarah S, Homeowner


text:
I will help You Understand The Threat Of Hackers To You(3)
About This Gig
Think you could pick a Hacker out of a crowd? The nerdy looking 13 year old wearing a 4Chan t-shirt right? Think again 2016 brings with it a whole new genration of criminal orginasations focused on stealing the information and identitys of everyday unsuspecting people, and now your data is at risk of theft more then ever before, and not just from a bunch of keyboard warriors or trolls but from highly organised criminal syndicates across parts of asia, russia and eastern europe what these syndicates aim to do is expansive but commonly consist of turning your computer into a slave to act on their behalf and carry out more illegal acts to stealing your private information so they can blackmail you for cash or just simple pretend to be you and destroy your life. The point is your digital information is no longer safe, and it isn't all as digital as you think with attack's such as social engineering, and attack's like MITM or war driving you may be completely oblivious to any intrusions or theft of your credentials. To learn how to detect these intrusions and more importantly DEFEND against them please order this all inclusive standard consultancy pack.
Thank you and be safe
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text:
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1001 Raheja Chambers 213 Nariman Point
Mumbai, Maharashtra 400001
The Firm was established in 1938, by late Mr. G. M. Kapadia. Given the high rates of taxation prevailing in India in the second half of the last century, the Firms' area of specialization was tax planning. With the rationalization of tax rates over the la ... more
G. M. Kapadia & Co.
www.gmkco.com [cached]
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Daytona Beach Area Convention & Visitors Bureau


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It has been used in the studies on some heterocyclic ligands showing linked ionization effects. 4-(Hydroxymethyl)imidazole HCl has been used in the synthesis of imidazole-containing peptidomimetic inhibitors.
Roslyn Atkins, et al. Copper(II) and nickel(II) complexes of unsymmetrical tetradentate Schiff base ligands.Inorg. Chem.,1985,24(2), 127-134.
Jukka Mäki. Bi-imidazole nucleosides obtained by ring opening of etheno and substituted etheno derivatives of adenosine.J. Chem. Soc., Perkin Trans. 1,2000,(24), 4445-4450.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.


text:
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Lot 2646: Ancient Roman Republican Coins - L. Furius Cn. f. Brocchus - Curule Chair Denarius
Coins: Day 5
by TimeLine Auctions
December 10, 2016
London, United KingdomLive Auction
Looking for the realized and estimated price?
Description: 63 BC. Rome mint. Obv: III-VIR BROCCHI legend to left and right and beneath bust of Ceres right, between a wheat-ear on the left and a barley corn on the right. Rev: L FVRI C N F legend above curule chair between two fasces. Furia 23; Syd 902; Crawford 414/1; Sear 365. 3.87 grams. .
Condition Report: Extremely fine.
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In the United States, exempt and non-exempt are employee classifications provided for by the Fair Labor Standards Act. These classifications are individually determined and must be applied to each person working in a business or organization. During the classification process, elements such as an employee's occupations, duties and salary are considered. Exempt or non-exempt status determines whether an employee is eligible to receive overtime pay or not.
All employees who earn $100,000 or more each year are automatically classified as exempt. However, for lower-earning employees to be considered for exempt status, they must earn at least $455 each week or $23,600 each year. They must also be paid on a salary, not hourly, basis. On the other side of the spectrum, non-exempt employees typically earn less than $455 each week or $23,600 each year, and are paid on an hourly basis. However, an employee's duties are the most important determining factor for exempt or non-exempt status.
Generally speaking, exempt employees are executives, managers and other high-level employees, while non-exempt employees perform more routine positions with lesser amounts of responsibility. More concretely, exempt employees usually supervise other employees; have authority over hiring and firing employees, assigning work and determining how the work is to be performed; make independent decisions; set budgets; manage and monitor the whole business or just a specific department; and assume responsibility for implementing workplace safety and legal compliance issues.
Employees in some professional occupations are automatically considered exempt employees. This applies to doctors, lawyers, architects, engineers, teachers and other intellectual-type professions that automatically require advanced degrees or specialized education. In addition, some high-level administrative positions are also considered exempt occupations when the employee has significant authority to make decisions that impact the business.
Record Keeping
Businesses are required to keep accurate time sheets or records for their non-exempt employees; they are not required to do so for their exempt employees, but they may do so if they wish. Non-exempt employees are required to be paid for the actual hours they worked as well as any overtime. Businesses may mandate that employees ask permission before working overtime, but whether permission was requested and granted or not, the employees must still be paid for all overtime worked. No matter how many hours an exempt employee works, the business is only responsible for paying the base salary and any other obligations such as bonuses or commissions. Exempt employees cannot earn overtime pay.


text:
Fingers crossed for you @Dougy!!
@SRC glad to hear it's all going well and you're enjoying it! It seems (from this end) that this five months has flown.
Thanks for all the lucky wishes x
@Dougy, here's hoping your little eggs have all fertilised
@Dougy, here's hoping your little eggs have all fertilised
Dougy (22-08-2015)
4 eggs have fertilised... I'm trying really hard to remember that it only takes one but I am a little disappointed! Hopefully they all make it another day, heading for a day 3 transfer on Monday.
It's so hard seeing them dwindle away but fingers crossed that one of those if your big sticky BFP.
Dougy (23-08-2015)
Pregnant for the first-time?
Not sure where to start? We can help!
Our Insider Programs for pregnancy first-timers will lead you step-by-step through the 14 Pregnancy Must Dos!


text:
7 Rue Paul Albert Paris 75018 France
Location The hotel is perfectly situated just 550 metres from Anvers Métro station in Butte de Montmartre. The Sacré Coeur Basilica is just 180 metres away and both the Palais Garnier opera house and the Louvre are less than 5 km away. The Moulin Rouge and the Place du Tertre are within a convenient 10-minute walk. Facilities Guests are welcomed at the hotel, which has a total of 24 rooms. Services and facilities at the hotel include a safe, a restaurant, a breakfast room, a café, a bar, a newspaper stand and a laundry service. Wireless internet access in public areas allows travellers to stay connected. Rooms Rooms feature air conditioning, central heating and a bathroom. A double bed ensures a good night's sleep. A safe and a minibar are also available. Guests will also find a mini fridge included as standard. Internet access, a telephone, a TV, a radio and WiFi add to the comfort of the holiday. Amenities in the bathrooms include a shower. A hairdryer can also be found in each of the bathrooms. The accommodation offers non-smoking rooms. Payment The following credit cards are accepted at the establishment: American Express, VISA and MasterCard.


text: All my beautiful snow has turned to rain and yucky mud...LOTS of rain and even more yucky mud. Today we got nearly 3 inches of rain in about 12 hours, with much more expected in the next couple of days. What does this have to do with the game thread? Simple... All the rain we're getting up here is going to end up down there. I'm just glad Golden 1 Center isn't located in the middle of a flood plain. Now, there's every reason for the Kings to lose this game against the Warriors. And since there is every reason for them to lose, it's almost a certainty the Kings will win. It's been that kind of a year. Remember to vote DeMarcus Cousins #NBAVote. #GoKings #LoyaltyIsLove #KeepYourPowderDry #WhatsACubit?


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Tag Archives: Website Revamp
Is MobileGeddon upon us? Google cannot ignore the massive growth of mobile devices and browsing anymore and reflects their decision to change their search algorithm on 21 April 2015 to favour sites that work well on mobile phones.
Read morePosted by Irma Zimmermann on April 8, 2015No Comments
Tagged:Google AlgorithmMobile BrowsingMobile DeviceMobile FriendlyMobile Friendly SearchMobile GeddonMobile PhoneResponsiveWebsite Revamp
Is your website healthy? Before you start loads of planning and sweating blood it really is worth your while pondering deeply and asking some of these questions first.
Read morePosted by Irma Zimmermann on September 14, 20142 Comments


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Tar Heel Times
Your comprehensive source for Tar Heel sports news
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UNC Baseball
Complete coverage of North Carolina Baseball.
UNC baseball improvises at Fall World Series due to injuries
Pitchers in the outfield and coaches in the infield. What sounds like a community league softball game is rather the state of the injury-ravaged North Carolina baseball team. As the Blue and Navy squads resumed battle this weekend in the Fall World Series at Boshamer Stadium (with the Blue team claiming 6-2 and 7-3 victories) the two sides were fighting just to field a team. (
Daily Tar Heel
Monday, October 13, 2014 |
Andrew Miller finds true talent as reliever
It was the eighth inning last Sunday in Detroit, and Andrew Miller was lighting the radar gun -- 97, 96, 87 (a token slider), 95, 96, 96. With two outs in a tight game, he got the great Miguel Cabrera to ground weakly to second base, then walked off the mound, strong and powerful as ever, somehow looking even taller than usual. (
Boston Herald
Saturday, October 11, 2014 |
Andrew Miller key to Orioles' ALCS plans
Now it can be told. Andrew Miller tried to convince the Red Sox to let him pitch in the World Series last season. The lefthanded reliever had surgery on his left foot in July to repair a torn ligament and was ruled out for the season. But as the Sox advanced deeper into the playoffs, Miller started playing catch. (
Boston Globe
Friday, October 10, 2014 |
Colin Moran hitting stride at Astros instructional league
Now that Colin Moran is in the organization, the Astros player development staff has been able to work with its latest pupil, beginning with the final month of the regular season and now instructional league. Director of player development Quinton McCracken said Moran has lived up to the scouting reports. "He's an extraordinary hitter," McCracken said. "He has a beautiful left-handed stroke." (
Wednesday, October 08, 2014 |
Kyle Seager's Gold Glove resume gets boost from The Fielding Bible
The latest praise for Kyle Seager's improving defense at third base comes from the stat wizards at The Fielding Bible, who have devised a metric to measure the accuracy of an infielder's throwing arm. Seager led all American League third basemen with a 96.6-percent "good throw" rate for his 267 throws to first base. (
Tacoma News Tribune
Tuesday, October 07, 2014 |
Left-hander Andrew Miller fits well in back of the Orioles' dominating bullpen
As left-handed reliever Andrew Miller spoke to the media in the clubhouse hallway Sunday night after the Orioles' American League Division Series clincher in Detroit, he was interrupted by a bellow. "You did it, Andrew," said the excited voice. "You did it." (
Baltimore Sun
Tuesday, October 07, 2014 |
Orioles' Andrew Miller turns the tables on former team
One wonders how occupants of the Tigers' executive box felt when they saw Andrew Miller jog in from the bullpen Sunday to help extinguish their season. This same front office made Miller the Tigers' first-round pick in June 2006. Within a few months, the lanky, hard-throwing left-hander from the University of North Carolina had ascended to the majors. (
Detroit Free Press
Monday, October 06, 2014 |
Andrew Miller gives Orioles an edge
The 6-foot-7-inch lefthander, who was traded from the Red Sox to Baltimore on July 31 for pitching prospect Eduardo Rodriguez, will garner much interest as a free agent this offseason. And he showed exactly why the Red Sox are among many teams who want Miller in their bullpen in 2015. (
Boston Globe
Sunday, October 05, 2014 |
Peter Gammons: After years of adversity, Andrew Miller is a major weapon for O's in October
Andrew Miller had just finished his freshman year at the University of North Carolina in the summer of 2004. He was pitching on a cool night in Chatham against Falmouth. He hit the leadoff batter, Jacoby Ellsbury. Twelve batters later, he was through the fourth inning and had struck out every one of those batters. Miller threw like a grocery cart rolling out of control down a ramp. Arms, legs. He threw hard. (
Gammons Daily
Friday, October 03, 2014 |
Fall World Series Rosters Announced
Seniors Benton Moss, Trevor Kelley and Chris McCue selected their rosters for the 2014 UNC Fall World Series, which is set to begin Friday, Oct. 3, at 5 p.m. Moss will captain the Blue team, while Kelley and McCue will lead the Navy squad. The first six Fall World Series games will be held at Boshamer Stadium and are open to the public for no charge. (
Thursday, October 02, 2014 |
Q&A with Orioles player Andrew Miller
With the Baltimore Orioles starting their postseason run tonight, Assistant Sports Editor Pat James caught up with former North Carolina pitcher and current Orioles reliever Andrew Miller. Miller is UNC's all-time leader in strikeouts and was selected by the Detroit Tigers with the sixth pick overall of the 2006 First Year Player Draft. (
Daily Tar Heel
Thursday, October 02, 2014 |
Yankees' Adam Warren puts seal on season
Adam Warren toed the rubber for the final time this baseball season. The New York Yankees' relief pitcher, and New Bern native, pitched 1.1 innings in the season-finale on Sunday against the Boston Red Sox. It was also the final game for teammate Derek Jeter. Warren finished the season with a 2.97 ERA with three saves in 69 appearances. (
New Bern Sun Journal
Wednesday, October 01, 2014 |
UNC Baseball Powers Past Ontario In Exhibition
The North Carolina baseball team allowed just three hits in an exhibition victory over the Ontario Blue Jays on Tuesday at Boshamer Stadium. Wood Myers went 3 for 3 in the contest with an RBI, a stolen base and a run scored and Skye Bolt finished a triple shy of the cycle as he went 3 for 4 with two RBIs and three runs scored. (
Wednesday, October 01, 2014 |
Tar Heels Announce Full Fall World Series Schedule
The UNC baseball team has finalized its annual Fall World Series dates for 2014. In addition to the three games this weekend, the Tar Heels will play six other intrasquad exhibitions, including three at historic ballparks in the state. UNC will open play this weekend beginning at 5 p.m. on Friday, Oct. 3, 6 p.m. on Saturday, Oct. 4, and 1 p.m. on Sunday, Oct. 5. All three games are free to spectators. (
Monday, September 29, 2014 |
Mets' Matt Harvey spotted at Yankee Stadium for Derek Jeter's final home game
Mets rehabbing ace Matt Harvey is in the Bronx for Derek Jeter's final home game. He was spotted in the stands by YES network cameras. The Mets are currently playing against the Nationals in Washington. "Must not be a Rangers game tonight," Mets GM Sandy Alderson said. (
New York Daily News
Thursday, September 25, 2014 |
Baseball Recruiting News
Rockingham Pitcher Angel Zarate Signs with UNC Baseball
North Davidson's Austin Beck Signs with UNC Baseball
UNC Baseball Ranks No. 2 In Baseball America Recruiting Rankings
Asheville Infielder/Pitcher Josh Dotson Commits to UNC Baseball
Angel Zarate commits to play baseball at North Carolina
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Basketball Recruits
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text:
Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts
Motta M.,Oncology and Molecular Medicine |
Motta M.,University of Rome La Sapienza |
Di bartolomeo S.,University of Rome Tor Vergata |
And 5 more authors.
Human Molecular Genetics | Year: 2012
Saposin (Sap) C deficiency, a rare variant form of Gaucher disease, is due to mutations in the Sap C coding region of the prosaposin (PSAP) gene. Sap C is required as an activator of the lysosomal enzyme glucosylceramidase (GCase), which catalyzes glucosylceramide (GC) degradation. Deficit of either GCase or Sap C leads to the accumulation of undegraded GC and other lipids in lysosomes of monocyte/macrophage lineage. Recently, we reported that Sap C mutations affecting a cysteine residue result in increased autophagy. Here, we characterized the basis for the autophagic dysfunction. We analyzed Sap C-deficient and GCase-deficient fibroblasts and observed that autophagic disturbance was only associated with lack of Sap C. By a combined fluorescence microscopy and biochemical studies, we demonstrated that the accumulation of autophagosomes in Sap C-deficient fibroblasts is not due to enhanced autophagosome formation but to delayed degradation of autolysosomes caused, in part, to decreased amount and reduced enzymatic activity of cathepsins B and D. On the contrary, in GCase-deficient fibroblasts, the protein level and enzymatic activity of cathepsin D were comparable with control fibroblasts, whereas those of cathepsin B were almost doubled. Moreover, the enhanced expression of both these lysosomal proteases in Sap C-deficient fibroblasts resulted in close to functional autophagic degradation. Our data provide a novel example of altered autophagy as secondary event resulting from insufficient lysosomal function. © The Author 2012. Published by Oxford University Press. All rights reserved. Source
De Zio D.,University of Rome Tor Vergata |
Cianfanelli V.,University of Rome Tor Vergata |
Cecconi F.,University of Rome Tor Vergata |
Cecconi F.,Laboratory of Molecular Neuroembryology
Antioxidants and Redox Signaling | Year: 2013
Significance: When lesions are unrepaired or there are defects in the DNA repair system, DNA damage is often correlated to apoptosis. However, different kinds of lesions and different degrees of lesion severity can trigger numerous signaling responses. Recent Advances: DNA repair proteins involved in specific DNA repair pathways can modulate the function or activity of some apoptotic factors, further emphasizing the crosstalk between DNA damage and cell death. Critical Issues: Here, we discuss the signaling networks that link DNA damage to apoptosis, and we focus on post-translational modifications, leading to crucial changes in protein behavior, following various kinds of DNA damage. Moreover, we analyze the existence of apoptosis-related functions of typical repair proteins, leading to diverse, often-overlapping, DNA damage responses. Future Directions: The better understanding of the regulation and the functionality of key DNA repair proteins, also involved in apoptosis regulation, has the potential of modulating the cell outcomes on DNA damage, particularly in the context of cancer treatment. Antioxid. Redox Signal. 19, 559-571. © 2013, Mary Ann Liebert, Inc. Source
Cianfanelli V.,Danish Cancer Society |
D'Orazio M.,University of Rome Tor Vergata |
Cecconi1 F.,Danish Cancer Society |
Cecconi1 F.,University of Rome Tor Vergata |
Cecconi1 F.,Laboratory of Molecular Neuroembryology
Cell Cycle | Year: 2015
Autophagy-promoting proteins and stimuli are often associated with inhibition of cell proliferation; in this context, we recently described a key role for the pro-autophagic protein AMBRA 1. Indeed, AMBRA1, through its direct interaction with the protein phosphatase PP2A, tightly regulates the stability of the oncoprotein and promitotic factor c-Myc. Moreover, the AMBRA1-mediated regulation of c-Myc affects both cell proliferation rate and tumorigenesis. Interestingly, AMBRA1/ PP2A activity is under the control of the master regulator of autophagy and cell growth, the protein kinase mTOR. Besides the mechanistic details of this regulation pathway which we dissected previously, any possible interplay(s) between AMBRA1 and its interactor BECLIN 1 was not investigated in this scenario. Here we show that both AMBRA1 and BECLIN 1 affect c-Myc regulation, but through two different pathways. Nevertheless, these two proautophagic proteins are, together with PP2A, in the same macromolecular complex, whose functional significance of which will be addressed in future studies © 2015 Taylor & Francis Group, LLC Source
Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response
Pagliarini V.,National Institute For Infectious Diseases Irccs L Spallanzani |
Wirawan E.,Molecular Signalling and Cell Death Unit |
Wirawan E.,Ghent University |
Romagnoli A.,National Institute For Infectious Diseases Irccs L Spallanzani |
And 12 more authors.
Cell Death and Differentiation | Year: 2012
Under stress conditions, pro-survival and pro-death processes are concomitantly activated and the final outcome depends on the complex crosstalk between these pathways. In most cases, autophagy functions as an early-induced cytoprotective response, favoring stress adaptation by removing damaged subcellular constituents. Moreover, several lines of evidence suggest that autophagy inactivation by the apoptotic machinery is a crucial event for cell death execution. Here we show that apoptotic stimuli induce a rapid decrease in the level of the autophagic factor Activating Molecule in Beclin1-Regulated Autophagy (Ambra1). Ambra1 degradation is prevented by concomitant inhibition of caspases and calpains. By both in vitro and in vivo approaches, we demonstrate that caspases are responsible for Ambra1 cleavage at the D482 site, whereas calpains are involved in complete Ambra1 degradation. Finally, we show that Ambra1 levels are critical for the rate of apoptosis induction. RNA interference-mediated Ambra1 downregulation further sensitizes cells to apoptotic stimuli, while Ambra1 overexpression and, more efficiently, a caspase non-cleavable mutant counteract cell death by prolonging autophagy induction. We conclude that Ambra1 is an important target of apoptotic proteases resulting in the dismantling of the autophagic machinery and the accomplishment of the cell death program. © 2012 Macmillan Publishers Limited All rights reserved. Source
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
Cianfanelli V.,Danish Cancer Society |
Cianfanelli V.,Laboratory of Molecular Neuroembryology |
Fuoco C.,University of Rome Tor Vergata |
Lorente M.,Complutense University of Madrid |
And 29 more authors.
Nature Cell Biology | Year: 2015
Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the scaffold protein AMBRA1, a member of the autophagy signalling network and a downstream target of mTOR, regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc. We found that AMBRA1 favours the interaction between c-Myc and its phosphatase PP2A and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate. As expected, such a de-regulation of c-Myc correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene. © 2015 Macmillan Publishers Limited. All rights reserved. Source


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Jason Anderson - Late night with the Burton team, Part III
Download this episode
What happens when a passionate program manager, Jason Anderson, kidnaps a handful of customers and a Channel 9 camera guy? An interesting discussion about test driven development. In this segment Jason shows how to add a new test in the next version of Visual Studio.
For those who missed the first two parts:
Part I
Part II
The final part will be here tomorrow.
For those who missed the first two parts:
Part I
Part II
The final part will be here tomorrow.
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Kevin Schofield - Tour of Microsoft Research (Social Software, Hardware)
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Part 7 - Understanding the Navigation Model
Part 17 - Understanding Data Binding, Data Sources and Data Contexts
A Developer's Guide to Windows 10: (10) SQLite Local Database
Part 6 - Styling Apps using XAML
Part 28 - Working with Animations in XAML
Part 4 - Understanding XAML Layout and Events
Part 3: Introduction to XAML
Part 18 - Understanding MVVM: ObservableCollection and INotifyPropertyChanged
Part 2 - Exercise: Writing your First Windows Phone 8.1 App
Part 5 - Overview of the Common XAML Controls
The Discussion
thnaks a lot for these videos, because for people who didn't have the opportunity to try VS.NET 2005 beta some functions were quite abstract.
I think lots of developer should thank MS to really listen to their requests because now we can have a real advantage when using MS softwares.
The code will be more secure (event if it's up to the developer) and for important projects tests would not be that complicated to implement...
For those who have problems understanding the prog manager, listen to rap music and it will become an habit! lol
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Опубликовал: xxxhall | Размещено: 5-01-2017, 20:15 | Комментариев: 0
Пиры: 26 | Сиды: 4 | Размер: 1.86 Gb
Название: То, чего он не знает . . .
Жанр: Gonzo, Mature, MILF, Old & Young Females (18+), Threesomes, Affairs & Love Triangles
В ролях: Brandi Love, India Summer, Cherie Deville, Alexa Grace, Sarah Vandella, Mick Blue, Chad White, Xander Corvus, Jessy Jones, Tyler Nixon
Продолжительность: 02:14:14
Описание: This Pretty Dirty compilation features impetuous girls being sexually cavalier and getting away with it! Cheating wife Brandi Love juggles secret lover Mick Blue and husband Chad White in the same afternoon, making sure everyone gets fucked and no one gets caught. Stepson Xander Corvus hides under step mom Sarah Vandella's desk, eating her pussy while she finishes a call with his out of town dad. When MILF teacher India Summer catches her students Alexa Grace and Jessy Jones skipping class to have sex, she gives them a choice, to tell their parents, or let her join. When Cherie Deville discovers a new service that runs errands, delivery boy Tyler Nixon earns five stars fucking her pussy and drenching her in cum.


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The chunky knit and striped pattern are the hallmarks of this BOSS Orange beanie. The percentages of wool, alpaca, viscose and silk in the material guarantee its softness. A cool men's beanie that gives urban looks individual charm instantaneously.
Ribbed hem
Circumference: approx. 52 cm
Circumference: approx. 52 cm
Material and Care
Material information: 32% Polyamid, 22% Wool, 19% Polyacrylic, 15% Alpaca, 8% Viscose, 4% Silk


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- 20Hz-20KHz
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- 7 feet Cord Length
- $24.99 24.99
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not what's pictured here 09/10/2012
This review is from: Cyber Acoustics AC-401 3.5mm Connector Circumaural Speech Recognition Stereo Headset & Boom Mic
probably decent
probably mildly cheap but effective
Other Thoughts:
The picture does not match what I bought when I bought. Pictured is a black headset showing the pink and green 3.5mm connectors and flat speaker covers. What I got was a silver headset with the donut padding that is supposed to go around your ears. Will look into return/ exchange but probably not worth it.
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DENVER (AP) - Sure, Peyton Manning said, he'd like to have played more this summer - and better.
SAN FRANCISCO (AP) - Outside linebacker Ahmad Brooks will not practice this coming week with the San Francisco 49ers, who sent him away from the team after he was charged with misdemeanor sexual battery Wednesday.
EDISON, N.J. (AP) - The toughest challenge Jason Day faced Sunday at The Barclays was convincing his peers that golf really isn't this easy.
SAN FRANCISCO (AP) - Marlon Byrd said there was only one way he could have enjoyed his birthday more.
PHOENIX (AP) - Marcus Semien's two-run single with the bases loaded and two outs in the 11th inning sent the Oakland Athletics to a 7-4 victory over the Arizona Diamondbacks on Sunday.
OAKLAND (AP) - Even though Carson Palmer spent much of the first half on his back and running from the Oakland defense, Arizona coach Bruce Arians is not concerned about his offensive line.
By DALE BOSOWSKI
SONOMA (AP) - IndyCar drivers got back to work Friday, climbing into their cars as a distraction - albeit a temporary one - from their grief over Justin Wilson's death.
NEW YORK (AP) - NASCAR star Tony Stewart said he didn't see a driver walking on a dirt track in upstate New York last year before he struck and killed him, and noted the racer was impaired by marijuana and shouldn't have been outside his car, according to court papers filed Friday.
ALAMEDA (AP) - With a starting running back that hasn't had more than 100 carries in a season since entering the NFL, the Oakland Raiders know they will likely have to count on some of their backups to generate a consistent running game this season.
SAN FRANCISCO (AP) - Rookie Kelby Tomlinson lined a bases-loaded single up the middle with one out in the ninth against previously unbeaten Kevin Siegrist, and the San Francisco Giants topped the Cardinals 5-4 on Friday night to snap St. Louis' five-game winning streak.
SAN FRANCISCO (AP) - Giants right-hander Matt Cain was put on the 15-day disabled list Friday with irritation in his pitching elbow and received a cortisone injection to help it calm down.
PHOENIX (AP) - Pinch-hitter Aaron Hill's double produced the go-ahead run in the seventh inning off Oakland ace Sonny Gray, Paul Goldschmidt homered and the Arizona Diamondbacks rallied for a 6-4 victory over the Athletics on Friday night.
NEW YORK (AP) - Serena Williams could play an All-American U.S. Open.
EDISON, N.J. (AP) - The start of the FedEx Cup playoffs brought out the worst score from Jordan Spieth in three months.
Page 231 of 901
ALAMEDA (AP) - While Derek Carr underwent surgery to repair his broken right leg on Tuesday, the Oakland Raiders began preparing for a playoff run without ...
SANTA CLARA (AP) - If Colin Kaepernick is concerned about his future with the 49ers, the veteran quarterback certainly isn't showing it. At least not ...
CLEVELAND (AP) - LeBron James was jolted forward when the massive crowd swelled from the sidewalks and into Cleveland's streets, surrounding the convertible that he ...
MIAMI (AP) - Russell Westbrook got his 15th triple-double of the season by the midpoint of the third quarter, and the Oklahoma City Thunder beat the ...
Just when it seemed the NFL was losing its tight grip on America's fans, America's team came riding to the rescue.
Page 25 of 25
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Last weekend, here in Texas, was tax free weekend. Everyone was getting ready to send kids back to school and most clothing and shoe stores were packed. I made a trip to the mall, which I only go when I need something these days, to hunt down some shoes and a few items. Of course, every store was packed. I made my routine stops in book stores and Gamestop to browse and caught the saddest thing a gamer could see.
The arcade was empty. The sheer lack of people in it caught my attention. The exact place that I spent so many summers and Saturdays honing my fighting game skills, killing time watching kids play DDR, felt like a graveyard.
I walked around the corner to see two guys into a Tekken 5 machine, one playing Soul Calibur and a family watching dad embarrass himself on a Sega, horse-racing game. I don't care how empty a place is. Nobody should witness a guy in his 40s making that motion on ANY kind of horse. Disturbing.
I really shouldn't be surprised that with the current generation of games, the arcades don't have crowds or interest like they did even a decade ago. The only store more desolate was an air brush T-shirt place a few doors down. I think even they were playing mobile games to kill the boredom.
Empty arcades are a sign of the times sadly. It also reminds me that I'm getting older. I used to fight crowds just to catch a glimpse of a screen of Super Street Fighter. I got destroyed on Marvel vs Capcom by a Vietnamese guy named Dan, that could beat anyone without looking at them. He used to look away, waiting for someone who could entertain him. He beat me so many times one day, I said "I know I suck but at least acknowledge me, damn!"
That was the first time I saw Dan smile. I made him laugh, so he showed me how to not lose as much. Then kicked my ass to remind me he could.
I used to kill time in there with my buddies before hopping movies in the theater next door. Tekken Tag tournaments led me to buy the game on PS2 and practice so I could make my 50 cents last more than two rounds.
I have some great memories from arcade gaming. I love consoles but before we could shoot people online in COD, watching a good match between two guys in the arcade and hearing the crowds was a familiar sound. You even knew what characters certain guys were going to play with. We called one guy "Ogre Charles" due to his routine Tekken Tag selection. These were our social networks. It sucks to see them go but I'll keep investing my quarters in other games.
I'm sure in a generation or two, some 30 year old guy will see an Xbox and remember his epic games of Halo: Reach. His kid will be busy playing a Nintendo 4th Wall hand-held, or something with an equally silly name. And someone else will be training to be the next King of Kong. Good memories, unlike high scores, can never be replaced.
Readers, what are some of your favorite arcade memories? What games did you blow your allowances on? Was it 4-player games like Gauntlet and Ninja Turtles? Did you put your quarter up for "next" in Mortal Kombat? Did you shoot the hell out of Area 51? Let me know what you played the most and if you still have an active arcade in your area.


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Philosophy 220 The Moral Status of the Non-Human World: Cohen and Warren
Regan and Animal Rights Tom Regan makes clear his commitment to the animal rights movement in the article "Are Zoos Morally Defensible." As he articulates it, that movement has three central goals. 1. Abolition of the use of animals in science. 2. The dissolution of commercial agriculture. 3. The elimination of sport hunting and trapping. Only abolition is possible. "You don't change unjust institutions by tidying them up."
Some Key Assumptions Regan specifies three assumptions central to his effort to establish that NHAs have moral rights and thus that we are wrong when we treat them like resources. 1. Some creatures are possessed of inherent value. 2. Those that are, are possessed of it equally. 3. Inherent value necessitates respect, where respect is understood (following Kant) as requiring treating possessors of inherent value as ends in themselves rather than means.
Advantages of the Rights View According to Regan, there are a number of advantages to thinking about moral standing in terms of rights. 1. In principle this view finds all forms of racial, sexual and social discrimination immoral. 2. In principle it denies that it is ever acceptable to trample on rights in pursuit of good consequences (zoos are cool, and presumably add a lot of utility, but if animals are rights holders, zoos are morally dubious enterprises).
The Argument 1. No appropriately rational argument can limit the scope of this respect to human beings. Can't specify a non-question begging account of inherent value that doesn't also include NHAs. 2. The property that explains our inherent value is being "the experiencing subject of a life." In our other vernacular, this is the property that establishes DMS. 3. We do not know (can not?) how far this notion extends, but we do not need to. It is clear that NHAs exhibit this characteristic. 4. Therefore, they have inherent value and thus the same right to respect as human beings.
Cohen, "Do Animals Have Rights?" Cohen takes up Regan's argument, ultimately rejecting his claim on the grounds of a different account of DMS. From his account, talk of animal rights is mistaken, as is Regan's characterization of a Cohen-type position as morally equivalent to racism or sexism (speciesism). He also disputes Regan's analysis of the moral status of the use of non-human animals on basically consequentialist grounds.
Rights and Animals Cohen begins his discussion with a definition of rights. "A right (unlike an interest) is a valid claim, or potential claim, made by a moral agent, under principles that govern both the claimant and the target of the claim" (348c1). Important features: distinction of rights from interests (disputed by other accounts of rights); specification of the function of moral agency.
Moral Standing and Rights Acknowledging the complexity of rights talk, Cohen offers an account of DMS which rules out the claim that animals (or other natural kinds) have rights. "Rights arise, and can be intelligibly defended, only among beings who actually do, or can, make moral claims against one another" (486c1). He ultimately grounds the capacity here indicated in a Kantian notion of autonomy. There is, Cohen makes clear, no CI for non-human animals.
What about Speciesism? Here too, the question of DMS looms large. Without arguing directly against Singer's use of sentience as the defining quality of DMS, Cohen denies that, "…all sentient animals have equal moral standing" (487c1). While racism has, "no rational grounds," insists Cohen, preferring humans to other animals does. They have rights after all?
What are the Consequences? It's easy to guess how Cohen is going to address questions concerning possible consequentialist analyses addressing, for example, animal experimentation. Any such analysis is going to have to provide a weighing mechanism by which we can compare the various utilities and dis-utilities involved. Cohen insists that the only appropriate mechanism should privilege human value over that of non-human animals.
Warren, "Rights Compared" The common moral intuition about the rights of Non-Human Animals seems to be that if they have rights, these rights are limited relative to human rights. If you could only save one would it be your new born infant or a loyal family dog that you've had for a decade? Warren thinks that advocates of rights for NHAs need to account for this intuited difference and she aims to provide it.
Strength and Content Warren focuses our attention on two different features of rights where differences between rights of humans and rights of NHAs might be apparent. Content: what the right protects. Strength: how strong overriding reasons would have to be.
Human v. NHA: Content Given the differences between the forms of consciousness and activity of humans and NHAs, there are going to be many, specific distinctions in content between human and NHA rights. Ex. Freedom of Movement These distinctions should not mask a great deal of commonality in terms of content. Ex. Right to Life
Human v. NHA: Strength In those places of overlapping content, the distinguishing feature of human and NHA rights is strength. In general, human rights can only be overwhelmed by reasons stronger than those which would overwhelm the rights of NHAs. Even if this is not true, the lack of autonomy and reciprocity in the granting and respecting of rights is good reason to hierarchize rights holders.
Infanticide, Again? Does this argument strand the human infant or the severely retarded individual on the side of the limited rights holders? Warren thinks not, both because they are potentially or partially autonomous and have value for us
Curnutt, "Vegetarianism" Curnutt is convinced that moral arguments for vegetarianism coming from consequentialism and rights-based theories are incapable of addressing all of the issues that have been raised. He offers in replacement an argument grounded in something like the harm principle.
The Old Arguments As Regan highlighted, consequentialists like Matheny will find it difficult to argue that the moral value of the consequences of actions will always require vegetarianism. Rights talk is so complex and contentious that even Regan doesn't get the job done.
NEW Review the NEW argument for vegetarianism as it is presented on (364c1). Some Notes: Prima Facie: on its face, presumed to be (but can be overridden). Ultima Facie: on its face, (can't be overridden). Animal: vertebrate. Clearly, (3), (5) and (6) are the key moves in the argument.
Killing Animals is Prima Facie Morally Wrong. Harm: something that adversely affects an individual or entity's interests Severity of harm dependent on centrality of interests. Welfare interests are those that are (a) definitive of basic well-being, and (b) because their realization is the necessary precondition of having interests. Killing NHAs harms them, independent of any consequentialist or rights-based analyses. Therefore, assuming harm is prima facie morally wrong, it is prima facie wrong to kill NHAs.
Animal Eating is Prima Facie Morally Wrong On the basis of the conclusion that killing NHAs is prima facie wrong, the conclusion that eating animals is also prima facie morally wrong follows from the acknowledgment that eating them requires killing them. A possible response comes from the recognition that rarely do animal eaters actually kill the animals they eat. Curnutt rejects this response on the grounds of an analogy with other forms of transfer (holocaust lamp; stolen stereo). Benefitting from a "morally nefarious practice" makes one complicit in the immorality. In some cases, we may have no choice. However, animal eating is clearly not one of them.
From Prima Facie to Ultima Facie The last step of Curnutt's argument is demonstrating that the Prima Facie wrongness of animal eating is in fact Ultima Facie wrongness. Demonstrating this requires arguments to the effect that the wrongness of animal eating is not overridden by competing moral concerns. Curnutt identifies 4 different claims to overridingness 1. Traditional/Cultural: many obviously immoral practices have been so supported, but that doesn't change our evaluation. 2. Aesthetic: aesthetic appreciation is not generally regarded as sufficient to override moral concerns. 3. Convenience: again, the fact that something is convenient is insufficient to override its immorality. 4. Nutrition: NEW is not committed to veganism, just lacto-ovo vegetarianism. Absent any persuasive claim to overringness, the prima facie wrongness of animal eating is thus ultima facie.
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Ram searches for Priya in the jungle - Ram comes across few injured people who have survived plane crash and also searches for Priya in the Jungle. Will Ram be able to find Priya? Will Vikram and Neha succeed in getting touch with Ram and Priya?
""Bade Acche Laggte Hai" is the story of two strangers getting married ... and falling in love.
Ram Kapoor, the business tycoon and Priya Sharma get married unwillingly but discover love and respect for each other after marriage. Their love is tested time and again by scheming circumstances yet each time it is their boundless love that emerges victorious.
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Teams dig in mud, rain for dead in Mexico slide
LA PINTADA, Mexico – Fourteen hours per body.
That's how long search crews with shovels, hydraulic equipment – anything they can muster – are averaging to find the victims of a massive landslide that took half the remote coffee-growing village of La Pintada, leaving 68 people missing.
The Mexican army's emergency response and rescue team slogged in several feet of mud and incessant rain with rescue dogs, recovering a total of five bodies as of Sunday.
Lt. Carlos Alberto Mendoza, commander of the 16-soldier team, said it's the most daunting situation he's seen in 24 years with the army.
La Pintada was the scene of the single-greatest tragedy in destruction wreaked by the twin storms, Manuel and Ingrid, which simultaneously pounded both of Mexico's coasts a week ago, spawning huge floods and landslides across a third of the country. The official death toll grew to 115 on Sunday, Interior Secretary Miguel Osorio Chong said.
"As of today, there is little hope now that we will find anyone alive," President Enrique Pena Nieto said after touring the devastation at La Pintada, adding that the landslide covered at least 40 homes.
The storms affected 24 of Mexico's 31 states and 371 municipalities, which are the equivalent of counties. More than 58,000 people were evacuated, with 43,000 taken to shelters.
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text: Home > Global Filipino Fil-Am brothers nabbed for gun smuggling By Balitang America Staff Posted at Sep 07 2013 11:41 AM | Updated as of Sep 09 2013 06:46 PM Share Save Facebook Twitter GPlus LinkedIn Pinterest SANTA ANA, California - Federal authorities have arrested two Filipino American brothers for an alleged arms smuggling scheme that involves a third brother in the Philippines. Wilfredo Maralit, a US Customs and Border Patrol officer at the Los Angeles International Airport, and his brother Rex Maralit, a New York Police Department officer, illegally shipped high-powered, military grade weapons to their brother Ariel in the Philippines. The scheme involved Ariel, soliciting buyers, while the other two brothers, who both worked in law enforcement, would acquire the weapons from dealers in the US. Federal officials then claim that Wilfredo and Rex would dismantle the weapons and arrange for the shipments to the Philippines. Wilfredo appeared at a federal courthouse in Santa Ana, California on Friday afternoon and was granted a $300,000 bond by a federal judge. Rex had also appeared in a New York courthouse on Friday. Federal officials are currently making arrangements to extradite Ariel from the Philippines to the US. Wilfredo is expected to join Rex in a federal New York courthouse on September 23rd. The three brothers face unto 5 years in prison for the unlicensed export of weapons. Share Save Facebook Share on Twitter GPlus LinkedIn Pinterest Read More: California gun smuggling Wilfredo Maralit Rex Maralit Ariel Maralit /video/news/02/27/17/in-the-loop-jim-paredes-berates-duterte-youth-members/entertainment/02/27/17/oscars-auditors-apologize-for-best-picture-mix-up/life/02/27/17/new-eats-theres-more-to-paradise-dynasty-than-xiao-long-bao/life/02/27/17/pia-marlon-join-celebs-in-bottle-flip-challenge/sports/02/27/17/wangs-basketball-stuns-ama-to-spoil-jerons-return


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Special Features
- Maureen O'Hara interview
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- May Murphey upstages John Wayne
- Jack Heanue & John Daly on the horse race sequence
- The annual Quiet Man fan club celebration
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This documentary looks at John Ford's efforts to create an idealized version of his homeland as the setting for his classic film The Quiet Man, and explores how his personal attachment to his parents' native Ireland informed the themes of the beloved film. ~ Perry Seibert, Rovi
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- Martin Scorsese
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- Maureen O'Hara
- Jim Sheridan


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But rescheduling marijuana would not have allowed doctors to prescribe marijuana nationwide. Coca leaves, from which cocaine is derived, are listed in Schedule II, but physicians cannot prescribe coca leaves -- and pharmacies cannot sell these leaves -- because no one has moved coca leaves through the FDA approval process to make them available by prescription.
The mainstream debate on encryption is tainted by an exaggerated reaction to the Snowden leaks. Many of those who side with Apple do so merely out of anxious suspicion of government surveillance by the NSA. We, however, reject this line of reasoning. Weakening encryption will make life easier for cyber criminals and cyber spies. But, at the same time, we have to find solutions to keep ourselves secure.


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Is Triple Venture incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Philippines provides information regarding Triple Venture in Cebu City Cebu. Triple Venture is located at 187, Leon Kilat Street, Cebu City Cebu 6000 and provides Travel services. Contact them on (032) 255 0684.
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We have more Travel services in Cebu City Cebu available on Hotfrog Philippines. You can update your search for Cebu City Travel by location, keyword or service options.
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Dia Mirza Walks On The Ramp During Lakme Fashion Week 2012
Dia Mirza Walks On The Ramp During Lakme Fashion Week 2012.
Gorheous Dia Mirza displayed the collection of designer Khushali Kumar at the Lakme Fashion Week Summer/Resort 2012 at Hotel Grand Hyatt, Mumbai. Collection is titled as Angels and Princess. On the sidelined she told that Khushali's theme was wonderful. One should feel confident wearing her outfit as Khushali's outfit makes you stand out in a crowd. It has the potential to make all the women absolutely gorgeous. Checkout Dia Mirza Pictures.
This entry was posted in Bollywood, Latest Fashion, Photoshoots and tagged Bollywood Events, Bollywood Updates, Dia Mirza, Dia Mirza Hot, Dia Mirza Pictures, Fashion Week 2012, Indian Babes, Lakme Fashion Week, Latest Fashion Style, LFW 2012, Walks On The Ramp During Lakme. Bookmark the permalink.


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Is this restaurant good for brunch?
Is this restaurant good for large groups?
Does this restaurant have a full bar?
Does this restaurant have a TV?
Can a vegetarian person get a good meal at this restaurant?
Can a gluten free person get a good meal at this restaurant?
Can a vegan person get a good meal at this restaurant?
Does this restaurant offer free wifi?
Does this restaurant offer delivery?
Does this restaurant accept reservations?
Thanks for helping!
We went mid afternoon for lunch. The service was prompt and the food very tasty. We ordered the pozole soup and lunch combo. The soup hit the spot.
My husband and I were up visiting in the area and stopped in here for dinner one night. We had the combo fajitas which were super tasty! The house margaritas tasted more like mohito's in our opinion but were still decent. Friendly and attentive staff. Delicious churro dessert too!
Always delicous, always friendly, the Carne asada, is the same every time, Delicious, you know it's great when the flavors are point on every time, chili relleno is my favorite, carne asada my husbands favorite, enchiladas my son's, great tachitos another of my favorites. You won't be disappointed.
We went mid-week for lunch. Great menu selection. Service was friendly and quick. The food was very good. Location was easy to get in and out of, even with lots of snow.
Food was truly delicious. Hubby had the largest burrito I have ever seen - it would have feed 3 people!
Don't try to drink here unless you go with the homemade almond tequila shots. The bar drinks are god awful and I've tried it a dozen times! Unfortunately it is the only Mexican Restaurant in town. The food is pretty good and popular with the locals.
Our waiter repeatedly tried to give us alternative options after we told him exactly what we wanted. The food wasn't good at all; all six of us agreed on that. The drinks were flat.
We were the first group to arrive and we didn't get our food for about an hour, after other people who showed up after us had...
pretty good, more authentic than tex mex thank goodness. Friendly staff, food was pretty good, rice was kind of dry like its been there for some time but good and affordable.
We are locals and eat at Azteca frequently. The food is great (carne asada and tres amigos are favorites), full of flavor and lots and lots of food. The margaritas on the rocks are also very good (frozen margaritas can be watery). They can be busy so you may have to wait for a table some nights. The only negative...
Friendly Mexican staff. Quick service. Large ice cold glass of mountain water. Very large oval shaped plate filled with two large burritos, one shredded pork and the other ground beef, along with beans, lettuce and rice. Costs was $10.45 plus $0.83 tax.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.
I'm having trouble finding an email address or website. I was wondering if you do offsite catering? If so, are there menus and prices online? Or do you have an email address I can contact you at for further information? Thank you.
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Who is TVB? – Part III Island Life
Here's the third episode in the Tim Van Berkel video trilogy, coming to you…
It's all about the basics
I'm in Hawaii, and the countdown to Kona is getting down to hours now….
Who is Tim Van Berkel? Part II – Boulder Brick
Here it is – Part II of the video series which Korupt Vision genius,…
Nine more sleeps
It's 1st October here and the Road to Kona is getting shorter and shorter…
Fuelling up for success
It seems incredible, but I think that as I get older I'm actually getting…


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This Mont Blanc platform cycle carrier attaches to your tow ball and carries one to four bikes. It has built in rear lights and number plate holder so you don't need to fit a trailer board.
See all in Cycle Carriers
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Duty and Desire
A Novel of Fitzwilliam Darcy, Gentleman
By (author) Pamela Aidan
Format: Paperback
Normal Price: $30.45
Your Price: $27.40 AUD, inc. GST
Shipping: $7.95 per order
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Plus...earn $1.37 in Boomerang Bucks
Availability: Available, ships in 8-11 days
Duty and Desire by Pamela Aidan
Book DescriptionHe's the fascinating romantic lead in what is perhaps the most enduringly popular novel in the English language. Yet Jane Austen reveals tantalizingly little about him, nor does she ever give readers insight into his take on the action of the book. And so the question has long remained: who is Fitzwilliam Darcy? Pamela Aidan's trilogy answers this question, creating a rich parallel story that follows Darcy as he meets and falls in love with Elizabeth Bennet. In this second installment, which covers the "silent time" of Austen's novel, Darcy is struggling privately with his feelings for Elizabeth but still must fulfill his roles as landlord, master, brother, and friend. When Darcy pays a visit to an old classmate in Oxford in an attempt to shake Elizabeth from his mind, he is set upon by husbandhunting society ladies and friends from his university days, all with designs on him-some for good and some for ill. Like its prequel, An Assembly Such As This, Duty and Desire will dazzle even the most discriminating of Austen fans. Aidan remains true to the original's spirit and events, masterfully capturing the Regency backdrop and incorporating fascinating new characters of her own to create an irresistibly authentic an entertaining novel.
Buy Duty and Desire book by Pamela Aidan from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780743291361
(203mm x 133mm x 25mm)
Pages: 320
Imprint: Touchstone
Publisher: Simon & Schuster
Publish Date: 3-Oct-2006
Country of Publication: United States
Other Editions...
Books By Author Pamela Aidan
These Three Remain, Paperback (January 2007)
A self-publishing phenomenon, Duty and Desire is the final book in the Fitzwilliam Darcy, Gentleman trilogy.
Assembly Such as This, Paperback (August 2006)» View all books by Pamela Aidan
A self-publishing phenomenon, Duty and Desire is the first book in the Fitzwilliam Darcy, Gentleman trilogy.
US Kirkus Review » Second installment of Aidan's trilogy retelling Pride and Prejudice from Darcy's point of view.While An Assembly Such as This (2006) closely followed Jane Austen's original opening chapters, the plot here wanders a bit farther afield as Darcy carries on his fictional life away from the world of the Bennetts. When his friend Bingley decides to forgo his love for Elizabeth's sister Jane, Darcy is relieved but not exactly happy. He still pines for Elizabeth, but only secretly and from a long distance; she never actually appears in this rendition. Darcy socializes in London and spends Christmas with his beloved younger sister Georgiana, who has recovered from her infatuation with the evil Wickham and committed herself to charity. She challenges Darcy's innate snobbery when she does the unthinkable and actually visits the poor in their homes. The bulk of the story, however, revolves around a country-house party Darcy attends in hopes of forgetting Elizabeth by finding a wife within his own social caste. The host, Lord Sayre, is a former Cambridge classmate, as are most of the other male guests. But Darcy soon realizes that the gentlemen are all bad-tempered fools, the ladies all desperately conniving to find husbands or lovers. Their petty intrigues take an ominous turn when the one genuinely innocent houseguest discovers a bloody piglet dressed up as a murdered human infant. Darcy is powerfully attracted to the bewitching charms of Lord Sayre's Irish half-sister, but she and her old servant prove to have dark secrets of their own. This sort of revisionism definitely has a readership, but Aidan's authorial arrogance and excessive reliance on research are evident in that she requires multiple installments to cover events that her predecessor nailed so deftly in a single volume.More reminiscent of Wilkie Collins than Jane Austen. (Kirkus Reviews)
» Have you read this book? We'd like to know what you think about it - write a review about Duty and Desire book by Pamela Aidan and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Pamela Aidan
Pamela Aidan has been a librarian for thirty years. She lives in Coeur d'Alene, Idaho, with her husband.
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Greetings Guest!!Dismiss Notice
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Returning player in Need of a lil help
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Blue Berry Strong Eyesight Management Tablets
60 Tablets
Featured Products
Description & Features+
Highly concentrated blueberry tablets with high content of bio-active anthocyanins and natural lutein which helps maintain a healthy macula of the eye.
Take 2 tablets daily with a meal.
Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Do not use if you are allergic to plants of the Asteraceae (daisy) family
Product Label Contents:
Medicinal ingredients per tablet :
Bilberry (Vaccinium myrtillus L.) fruit 5:1, equivalent to 2000mg dried fruit ...400mg
Lutein (Tagetes erecta L. (flower)) ...5mg
- Lutein: Found in marigold flowers, spinach and other green leafy vegetables. According to clinical studies you should take at least 6 mg of Lutein per day. This is done most easily by taking a supplement.
- Blueberries: Known from the Second World War when the fighter pilots were eating blueberries before their raids to better their night sight. Blueberries are rich in flavonoids, which are good for the small blood vessels and will decrease the build up of toxins. Phyto-ingredients from blueberries are also said to have a beneficial influence on the enzymatic processes in the eye.
Assembled product dimensions: L 10.20 cm x W 11.70 cm x H 2.10 cm x W 87.00 grams
Store Availability+
From the Manufacturer +
Sponsored Products


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to the Leicestershire and Warwickshire Volkswagen owners' club, the long established club for all enthusiasts of VW vehicles in Leicestershire, Warwickshire and surrounding areas.
Whether you own a daily driver, or a show winning concours VW, we welcome you all.
We hold regular meetings, organise the annual Stanford Hall show and can usually advise on technical problems, spare parts and general help in keeping VWs on the road. We also organise local social events and convoys to Volkswagen shows and other motoring events.
After a record breaking 2016 Stanford Hall show we hope to see you at the next show the 42nd Stanford Hall VW Event which will be in April 2017.
Hope to see you soon
Hinckley Classic Car Show 2016
Club display at the annual classic car display in the Leicestershire town of Hinckley
Lavenham 2016
Club trip to Lavenham Classic VW Show, Suffolk.


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For the cake
250g (9oz) unsalted butter
275g (9 1/2oz) golden caster sugar
4 Brown Eggs
275g (9oz) self-raising flour
a pinch of salt
1tsp vanilla extract
2 lemons, finely grated zest and 3tbsp juice
250g (9oz) finest* Greek yogurt, plus extra to serve
2tsp icing sugar
For the lemon drizzle
2 lemons, zest and juice
150g (5oz) golden caster sugar
Butter and line the base and sides of a 23cm round, springform cake tin. Preheat the oven to Gas Mark 4, 180°C, fan 160°C. Beat the butter and sugar together with an electric whisk until fluffy and light. Add the eggs, one by one, beating well between each addition.
Fold in the flour and salt to make a smooth batter. Fold in the vanilla extract, lemon zest and juice and 100g of the Greek yogurt. Pour into the tin, smoothing the top and bake for 50 minutes to an hour, until golden and springy on top. Spike the cake all over with a skewer.
Combine the lemon zest, juice and sugar for the drizzle and pour over the warmed cake. Set aside to cool completely in the tin.
Stir the icing sugar into the remaining 150g (5oz) Greek yogurt. Serve slices of cooled cake with spoonfuls of the sweetened yogurt.
Freezing and defrosting guidelines
Bake according to the recipe but stop before adding decoration or icing if called for. Allow to cool completely. Wrap well in clingfilm and tin foil (to prevent freezer burn) and freeze for up to 3 months.
Loosen the tin foil and clingfilm but leave to defrost in packaging at room temperature for several hours before serving.
If you wish to add icing or decoration, add them after the baked goods have fully defrosted and are at room temperature.


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See Details on eBay
Seller: myblueeyedjay1 (195) 100%,
Location: New Durham, New Hampshire,
Ships to: Worldwide,
Item: 282110921911
Vintage Square Nails with a flat head that were never used. 2 1/4" Long. Nails do have a rustic patina. Lot of 50 nails.
See More
274 Views, 4 Watching, Super high amount of views. Good amount watching. Good amount sold, 2 Sold, 8 Available.
Over 195 items sold. 0% negative feedback. Top-Rated Seller! Ships on time with tracking, 0 problems with past sales.


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When I was scrolling through the draft picks by the Buffalo Bills in the last 20 years, seeing the name Nate Clements brought back a multitude of memories from his years in Buffalo. If I could describe Nate as a football player in one word, I would use 'Driven'.
To establish a little history here, for those of you who don't remember Nate Clements upon leaving the Buffalo Bills in 2007 Clements became the highest paid Defensive player in NFL history when he signed an eight-year $80 million dollar deal with the San Francisco 49ers. For the record, the NFL has since had 2 players who have received larger Defensive contracts. Albert Haynesworth (WSH $100 mil) and Mario Williams (BUF $96 mil)
In this highlight video, you will see that he makes some of these spectacular plays look like it's just another day at the office. You can teach football skills, but you can't teach athleticism. You can get stronger with proper coaching and training, but you can't teach a player to want something bad enough to not accept any other option. It is not very often that you see a NFL player standing 6'0", weighing 190 lbs and run a consistent 4.40 – 40 yard dash. Fellow Buckeye and Buffalo Bill Antoine Winfield ran his best 40 at 4.39 seconds. To me, it is obvious that Nate knows what he is going to do before doing it. The aggressiveness, the physicality and complete domination in one on one situations made him a true master of his craft.
The first thing that fails an athlete when fatigue begins to set in is the mental awareness. You will see in this video how consistently Nate is beating his opponent to their spot. He had a knack for knowing the shortest line to take when chasing down a RB/WR who has broken open for a big play. His anticipation of where the ball is going to be thrown or deflected made him even faster than he actually was physically. He recorded an astounding 36 interceptions throughout his 12 year career.
He thrived when he was trailing an offensive player. With the obscured vision due to the football helmet, Clements could rip or poke the ball out of the Offensive players hands before they realized what happened. He was viscous when tearing the ball off of a player trying to go to the ground and as a result he recorded 22 forced fumbles over the course of his career.
One of the highlights that I will always remember of Nate Clements is one that I think all Bills fans smile at. Take a look at the video below. If you consider yourself a Bills fan then I don't think you will be able to watch it just once.
you can follow Brad Reiss on Twitter at @ReissBrad and be sure to like our facebook page


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Consistency and relevance are your best allies when grabbing the attention of global customers and keep feeding them. You should also bear in mind some dependencies and factors that are tied to digital globalization as a whole. Here are some points that are even more crucial to consider when deploying and valuing bite-sized content internationally, wherever it must be understood, consumed, remembered and shared.
Nov 01, 2011
Appcelerator, Inc. -- a platform to create apps for mobile devices, tablets, and desktops -- garnered a $15 million endowment in a third round of funding. This latest deal gives the company a total $31.5 million investment.
The round was led by Mayfield Fund, Red Hat, and Translink Capital, and included existing investors eBay, Sierra Ventures, and Storm Ventures.
To date, there have been approximately 30,000 apps developed on Appcelerator's Titanium platform. Appcelerator offers several products in its Titanium suite through four freemium developer plans: Community, Indie, Professional, and Enterprise.


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We Do Roofs
Roof Repairs, Roof Repairs Melbourne, Roof Repairs Altona
As soon as you notice any rain drops, wet spots, water stains on the plaster, call We Do Roofs to organise a roof professional to come out to your property, whether it is Geelong, Melbourne or surrounding areas, Altona, Williamstown, Little River, Werribee, Hoppers Crossing, Wyndham Vale and repair the leak before it gets worse.
Print this page
We Do Roofs provide professional Roof Painting Services.
We Do Roofs use only the best roofing products to ensure the finished result is as high quality as their
We are experts in Roof Maintenance and Gutter Cleaning Services. With our expertise as well as extensive understanding of roof
Are you looking for a full roof restoration in Geelong? Our qualified Geelong based tradesman can restore your roof back
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Pvc Compounds For Food Packaging And Plastic Commodity - Chinaprice: contact company for price
corresponded with FDA by SGS. No Phthalates. According to the
dosage of auxiliaries, elastic pvc compounds or rigid pvc compounds
can be produced.
All the pvc compounds are eco-friendly and non-toxic. The pvc compounds can be widely used in:
Plastic cup
Package for food
plastic wrap
Other aspects
According to the requirements, PVC compounds with different properties can be customized.
How to keep the PVC compounds
Please keep the PVC compounds from moisture and keep the environment clean. For more information, please contact me.
About samples
We provide a few samples free on the basis of freight collect payment. The period of proofing is 3 to 6 days, except the special situation. Other questions can be discussed each other.
About package
We provide different packages for you to choose. Normally, we recommended the craft paper bag package or vacuum package.
For more information, please contact me.
Company Contact:
- Posted By: jiangyin YFY chemical&plastics co.,ltd
- Phone: 8651086515960
- Address: no.1 dongfang industrial zone, qingyang town, jiangyin, China
- Email:
- Website: http://cnyfy.en.alibaba.com/
Published date: September 28, 2013 -
- Business Description: Jiangyin YFY Chemical & Plastics CO.,LTD is a private enterprise
integrated with researching&developing, produing and trading
founded in 1995.
After striving for many years, now, we are experienced in this field. More than 1000 full fledged products and over 100 kinds of colors are in our product library for you to choose from. Whatever hardness(rigid, semi rigid and flexible, etc. )and process(extrusion or injection molding) you wants, you will be satisfied here.
With the YFY Technology R&D Center founded in 2011, the research of the new products opens up new prospects for the company.
YFY pvc compounds can be widely used in the following scopes:
Wire and Cable ( PVC insulated, PVC for sheath, PE elastomer, etc. )
Household appliances (refrigerator sealing strips, soft hard co extrusion material, air conditioner flexible curtain, tube, etc)
Automobile (sheath for quarter window, parking brake, gear lever, handle, etc. )
Medical Accessories (infusion tube, infusion vessel, etc. )
Other PVC applications (model, flexible material, furniture parts, etc. )
YFY has 5 production lines and the annual output has achieved 10000 tons. We will provide top quality products and best after sale service for every customers.
Related listings
Pvc Compounds For GabionsPlastic - Raw Materials - jiangyin YFY chemical&plastics co.,ltd - China - September 25, 2013 - contact company for price
This kind of PVC compounds is usually rigid, torsion resistant, erosion resistant and weatherproof. In can be used in the manufacturing of different protective fence. Protective fence also be called as gabion, double twisted hexagonal steel wire mesh...
Special Cold Resistant Pvc CompoundsPlastic - Raw Materials - jiangyin YFY chemical&plastics co.,ltd - China - September 25, 2013 - contact company for price
Features:Compared with the normal pvc compounds, this kind of pvc compounds is more suitable for cold weather. Its brittle temperature can below -30 centigrade, the specific temperature can be adjusted by different additives. Samples: normally it wil...
Special Oil Resistant Pvc CompoundsPlastic - Raw Materials - jiangyin YFY chemical&plastics co.,ltd - China - September 25, 2013 - contact company for price
This pvc compounds is for oil-resistant plastic products. the pvc compounds can keep the oil from extracting . generally, it can be used in the automobile parts, sealing strips or any other products which oil- reisitant is needed. this PVC compounds ...
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Lady Kat's Birthday Party, presented by [OPEN], Sunday 9th March, 4pm AEST
Discussion in 'UO Oceania' started by Cymoril, Mar 5, 2008.