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Promotional keyrings in Memphis
Found: 5 products← Back to category "Outdoor advertising"
Infinity - Solar keychain with three LED's.
Brand: Infinity. Description: Shine a light on your latest green initiatives with this solar powered key holder! This eco-friendly item features 3 LEDs, solar charge and key chain to hold keys and other items. With a high intensity light beam, you'll be able to easily illum Read more
USA, Memphis
Promotional Keyrings
Promotional keyrings make an inexpensive and functional corporate gift, and with our wide range of designs you're sure to find one that suits your business perfectly. Read more
USA, Memphis
Pill Dispenser Key Tag
Compact dispenser allows for convenient access to pills. Comfortably fits in pocket or purse. Includes 1" split ring. Read more
Rectangular Key Light
Push and hold button to light. Long life batteries included. Strong white light. Silver trim gives this flashlight a classy look. Read more
Promotional keychains
Promotional keychains let you put your brand in front of recipients every single day. The quality and favorable prices. Read more
USA, Memphis
Similar goods in USA
Custom Displays
We can create a variety of Point-of-Purchase and Promotional displays to meet any requirement you might have. Please contact us today to discuss how we can meet your needs. Read more
Delivery to Memphis fromHicksville
Nylon Key Ring
Strong, nylon attachment holds your logo. Metal security ring. Availabe in red, blue, and black. Your Logo is protected with our TOP Epoxy Dome - never rubs off lasting a lifetime! Read more
Delivery to Memphis fromPerry
Stack Digital Clock
Posable digital desk clock. Display includes time, date and alarm functions. Item Size: 2-3/8" H x 2-3/8" D. Read more
Delivery to Memphis fromCassopolis
Checks Cashed Neon Sign
Checks Cashed Neon Sign SKU#B7-0407 20"x37" Checks Cashed done with more street appeal than most signs like this. Put this in your window and watch the business pick up. Much more effective than vinyl in your windows or banners that can only be seen during the day. Usually ships in 3-4 business Read more
Delivery to Memphis fromAustin
Apollo Grocery Tote Bag
Two-tone tote features a large open main compartment with a supportive bottom board. Double 20" reinforced handles. Reusable and a great alternative to plastic bags. Read more
Delivery to Memphis fromTampa
11 oz Windstone Ceramic Mug
Features 11 Ounce C-Handle design High gloss ceramic construction 4 Colors available Timeless design Includes one color imprint. BPA Free Imprint Area: 2 Side (standard) 2-1/4" H x 2-1/2" W per side. Read more
Delivery to Memphis fromChattanooga
Easy Hang Drawstring Backpack
- Trendy drawstring backpack. - Made from sturdy 80gsm non-woven polypropylene. - Extra large imprint area. Read more
Delivery to Memphis fromWest Palm Beach
Cotton Tote Bag
- 100% Natural Cotton - 30" Handles. - Note: Other decorating methods available, please call. - Approximate Bag Size: 15" W x 15" H - Imprint Area: 8" W x 8" H. Read more
Delivery to Memphis fromHighland Park
Drawstring Grocery Tote Bag
This is not your typical shopping tote. The insulated Drawstring Grocery Tote comes with a drawstring closure so your items don't fall out. Read more
Delivery to Memphis fromShallotte
Classic Ironstone Mug
This favorite classic mug is a great place to display your ad! Classic design Large C-handle Glossy exterior/interior. Read more
Delivery to Memphis fromUrbandale
Cambridge Pen
The twist-action Cambridge pen comes with a Cross style cartridge and is available in 4 great colors. Mechanism: Twist-Action. Ink Color/Point Style: Black ink with Cross-style medium point. Read more
Delivery to Memphis fromGrand Rapids
Non-Woven Tote Bag
- Ideal Size - Non-Woven Polypropylene Material - Tear Resistant - Water Repellent - Side & Bottom Gussets - Hemmed Opening - 22" Straps - Up to 20% Reusable/Recyclable - Full Color Digital. Read more
Delivery to Memphis fromArnold
Bounty Ceramic Mug
Offering a classic design and budget friendly price, these 11 oz. Custom Ceramic Mugs are a best bet for brand exposure. The Bounty Mug features a C-shaped handle and your choice of colors. Additional charges apply for colored mugs. Read more
Delivery to Memphis fromAustin
Jumbo Shop-n-Carry-All Tote
Sturdy, super-sized bold color tote made from a combination of natural jute fiber and recycled PET material, Soft to touch, but strong and durable, Contrasting beige color accents, 2 Side catch pockets. Read more
Delivery to Memphis fromAlameda
Scripto Groovy White Ballpoint Pen
Groovy grip designed with fingers in mind. Spray rubber grip details for writing comfort, white barrel and vivid color accents. Retractable click action mechanism, black ballpoint ink cartridge with tungsten carbide tip. Read more
Delivery to Memphis fromSantee
Aspen Meeting Tote Bag
Zippered main compartment with double 29" handles. Open front pocket. Two pen/USB flash drive slots and D-ring. Read more
Delivery to Memphis fromOrange
Evolve Bamboo Pen
Evolve push-action ballpoint pen with bamboo barrel and plastic trim. Due to our high standards of quality control, we must advise that slight irregularities in the bamboo wood of these pens may result in imprint imperfections. Read more
Delivery to Memphis fromLawton
Hanging Toiletry Kit BG700 Bag
An essential for every traveler. Features toothbrush and makeup holders and see-through pockets to view toiletries and accessories. A hang-anywhere hook makes it easy to hang on a door or towel bar. 1,680 denier ballistic polyesterWeb top handleExterior zippered pocketsDimensions: 10"h x 9.5"w x 4" Read more
Delivery to Memphis fromMurphys
Delivery to Memphis fromDunmore
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Trading platform Allbiz offers to see the catalog Promotional keyrings which contains 5 products offers from 4 companies and enterprises. Don't know what Promotional keyrings to buy? You can clarify the specifications, see photos Promotional keyrings and choose the best seller and supplier. Buy Promotional keyrings trough online ! On Allbiz — You can just place your order right on the site.


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3S locker
Plastic Locker, pvc locker, pvc plastic locker,
Looking for lockers to match the luxury of your hotel or spa? Look no further with PVC lockers only by 3S a Locker & Lock brand. PVC locker is made up of grey rigid pvc (poly vinyl chloride) plastic material.
PVC Locker Features:
- Strong, durable and lightweight
- Rust proof
- Comes in many colours
- Size can be customized.
- Optional shelving available
- Smooth surface finishing
- Post-formed door design
- Applicable for commonly used cabinet/locker locking system (key lock, coin return, digital lock and padlocks)
For more info, visit our website at: www.3slockers.com
Visit our facebook at: www.facebook.com/lockernlock
Print this page
W900 is the biggest size among our ABS W-series. Abs lockers are suitable in humid and high moisture areas hence they are ideal for swimming pools, changing rooms, water parks and more.
With plastic properties characterized by high impact resistance and toughness, ABS is your tough locker system whether in high moisture or dry areas.
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subset: commoncrawl


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ReadyToFind Web DirectoryHealthDisabilitiesParent Category: Disabilities
|Value Hearing
Affordable Hearing Aids products in Australia, Sydney, Canberra, Gold Cost & Perth. Value Hearing supplies hearing aids from all the best brands. Hearing aids prices often significantly lower than the majority of our competitors. We don't cut corners in order to offer you the best value in hearing aids and related services in Australia.


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IECSC is the leading spa and wellness event in the southeast. With a stellar conference program and dynamic tradeshow floor, you will have the opportunity to purchase products, see the latest trends and learn the newest techniques emerging in the spa and wellness market.?It is focusing on Spa Business & Wellness, Makeup and Medical Spa Education, Additional business building classes. Spa and wellness professionals rely on IECSC for insightful guidance to grow their businesses and keep them at the forefront of their competitive industry.
Visitors Attending
Buchaiah UppuneetiHome Loan Counselor at Easyloanbyub.comHyderabad, India
Ninoska SmithEsthetician at Natural And Organic Spa Orlando, FlOrlando, United States Of America
Edmy PenaMedical Aesthetician at Www.epidedmy.careGreater Philadelphia
BradyEntrepreneur at CcSarasota, United States Of America
Deanna AndreescuMedical Aesthetician/marketing/sales at West Palm Beach, FloridaWest Palm Beach
Danielle HoweSenior Executive at MytimeSan Francisco
Sabine GuptonDelivery Driver at Hungry Howie's PizzaCape Coral
Map & Directions
Greater Ft. Lauderdale / Broward County Convention Center
1950 Eisenhower Blvd, Fort Lauderdale, FL 33316, USA
Fort Lauderdale, USA
Featured Hotels
|Riverside Hotel From USD 129
|Hampton Inn Ft. Lauderdale /Dow.. From USD 84.15
|Sabrina Village From USD 424
|Tropical Oasis Condos From USD 129
Exhibitor Profile
Profile for exhibit include Plastic surgery, Equipment and instruments for plastic surgery, Haircare and bodycare products, Decorative cosmetics, Perfumery, Cosmeticians, Professional equipment, instruments and accessories for beauty salons, Manicure and pedicure equipment and instruments, SPA industry, Solariums, Nutrition / Diets, Medical products, homeopathic remedies and vitamins, bioactive supplements, Baby care products, Hygiene appliances.
Exhibitors List
|Exhibitor Name
|Products & Services
|London Brush CompanyEl Segundo, USA
|Soft Fan Duster Brush,Piece Classic Pro Brush,Piece NouVeau Pro Brush,All Purpose Brushes,Arc Blender Brush,Flexible Favourite Brush
|Cirépil by Perron Rigot ParisMelbourne, USA
|Spring Water,Body Lotion,Bleaching Cream,Skin Moisturizer,Wax Heater,Cartridge Heater
|Kryolan Professional Make-upChennai, India
|Eye Shadow Trio-Set,Brilliant Color Medley,Cake Eye Liner,Cine Wax,Tv Paint Stick,Professional Eye Shadow Set
|Bon Vital Inc. / BiofreezeHartland, USA
|Bonvital Organica Massage Lotion,Massage Creams,Bon Vital Naturale Massage Creme,Bon Vital Foot Balm,Bonvital Organica Massage Creme,Naturale Massage Creme
Visitor's Reviews17 Ratings / 10 Reviews
Was phenomenal, I truly enjoyed the whole event! Thanks guys the amazing job the you put together. :)
Edition Attended : Oct, 2016
Everything was just perfect I got to see my mentor and buy awesome things will go back !
Edition Attended : Nov, 2015
Was very good, unfortunately I didn't had time to stay longer. Next time! ??
Edition Attended : Nov, 2015
Thought there would be more vendors and more classes
Edition Attended : Oct, 2016
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Cosmetics and Beauty Products
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|Apr 182017
|CLIA Cruise360Fort Lauderdale, USA


text: Been meaning to get down to recruitment centre for a long time now, i went when i was too young and they said come back when you're old enough. Thing is, since then i'v become more and more unfit, obviously making me even more unlikely to go down there and make a royal tit of myself. i viewed the 1.5 mile run time thread (what a treat by the way), and there was mention of a "mock" fitness test, probably just what i need, so what do i do? half arsed train for longer, or just man up and go down there and see what happens?


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What sets Madison Hospitality Services apart? Spacious floor plans with fully equipped kitchens and private bedrooms. Our luxury communities offer an array of services including full-size fitness centers, swimming pools and spas, business centers, in-room washers and dryers, and resident activities and programs. Whether you need accommodations for yourself or for an entire corporation, we can help you find the best in apartment home living anywhere in the nation. Work with our relocation team to select the best option for you from a variety of communities and floor plans. Whether you are looking to be in the hustle and bustle of the city center or need a more quiet location our communities are located in both suburban and urban residential areas to make living and commuting easier. Relocating to the area or need a long term housing solution? We can help you transition into one of our apartment communities and relocate to the area with ease.
* Optional amenities may be limited. Additional charges may apply.
We offer a variety of options in and around Washington DC and Arlington, VA. Exact location and directions will be provided upon booking
As you search for your perfect accommodations, keep in mind that rates (including specials or discounts) and availability are very fluid and sometimes negotiable based on community guidelines. Based on many factors, the rates, specials, discounts and availability can change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rates or availability you may find here now at CorporateHousing.com may not be the same as when you contact the communities.


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Comment Re:wars destroy wealth (Score 1) 429
Yes, start with insults, that's always a good way to prove that you have the intellectual high-ground
- I don't see the difference, how I start is irrelevant. The relevant factor here is your government provided education and it has done the job.
What happens to these goods after they have been produced and exchanged, if there is nobody to consume them.?
- the only way to consume something is to produce something of your own and to exchange for what you are interested in consuming. Thus the people who can actually consume something are those very people that produce. This should be obvious even to you with a simple example: a farmer produces and then consumes what he produced. Got it? A farmer can exchange with a tool maker if the tool maker provides farmer with the tools the farmer needs and the tool maker clearly needs to eat. Etc.
It's consumption of non-domestic products that cause a trade deficit, not consumption by itself.
- consumption by itself is irrelevant, you are correct however, it is consumption of goods that were *not paid for* that causes the trade deficit.
only a very small portion of what you pay for a Chinese-made product actually goes to the Chinese company
- really? Are you an accountant for one of the Chinese companies? I actually deal with Chinese manufacturers for GPS trackers and other electronics, you are incorrect.
I'm curious which school YOU went to, where you were taught that taxation is theft
- I deduced it from the first principles. If you are wondering though, I went to the most communist school of all, I was born in the USSR and attended the public education system there. I was happy to see the country collapse of-course since it only confirmed my understanding of economics.


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2 Bedrooms Terraced House for sale
Baker Street, Poolstock, WN3 5HG
Boasting a full scheme of redecoration throughout and available with the added benefit of no upward chain - this smart, modern 2 bedroom townhouse is the perfect starter home for any…
Thinking of selling or renting your property?
Get a instant valuation today!
Free Instant Valuation
Find out if you are charging enough rent or what your property would be worth if you were to sell now


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I'm looking for a: Woman
Me gustaria conocer una persona buena. Que le encante caminar de la mano e ir abrazados por cualquier lugar del mundo.
Purpose of Travel: Beach break
Finances: I would like someone to pay for me
An email was sent to with an activation link.
New email has been sent. Check your junk folder.
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or connect with


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Greetings Guest!!Dismiss Notice
In order to combat SPAM on the forums, all users are required to have a minimum of 2 posts before they can submit links in any post or thread.
Ea/Mystic Needs a heads up .... in my opinion one long over due.
Discussion in 'UHall' started by Lady Storm, May 28, 2009.


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text: When evaluating new vehicle designs, modeling and simulation offer techniques to predict parameters such as maximum speed, fuel efficiency, turning radius, and the like. However, the measure of greatest interest is the likelihood of mission success. One approach to assessing the likelihood of mission success in simulation is to build behavior models, operating at the human decision-making level, that can execute realistic missions in simulation. This approach makes it possible to not only measure changes in mission success rates, but also to analyze the causes of mission failures. Layering behavior modeling and simulation on underlying models of equipment and components enables measurement of more conventional parameters such as time, fuel efficiency under realistic conditions, distance traveled, equipment used, and survivability. To maximize these benefits, the behavior model must be designed in a way that is able to take advantage of a variety of vehicle capabilities, rather than being tailored to a particular vehicle design. The model needs to be driven more by "first principles," such that its behavior in any particular situation is dynamically determined by an assessment of its own vehicle capabilities compared to the needs of the situation. For example, the range of some sensor may determine whether or not the appropriate behavior when detecting a superior force is to advance, withdraw, or "circle the wagons" by assuming a defensive posture. Most ground vehicles serve a variety of missions, so to generate a projection of mission outcome requires generating a sufficiently broad range of mission conditions such that there can be confidence in the vehicle evaluation. Hand-coding specific mission scenarios in simulation is too labor intensive, while generating every aspect from scratch may result in scenarios that are unrealistic. A middle ground is hand-coding the scenario basics, but then varying specific aspects. For example, the particular kinds, locations and routes of hostile forces, the time constraints, and the weather could be varied while holding the terrain, starting location, and goal location constant. We discuss past and current examples of behavior models and scenario variation in simulation in support of model-based system engineering, training, and vehicle autonomy.


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Rusty Dude! Mens Long Sleeve T-Shirt
A classic 1950 Ford Coupe...1949 was the year that Ford really changed their design for Ford, Mercury and Lincoln. Basically, you can tell the fifty Ford from the forty nine by looking at the parking lights on the front-end. The 49 had tear dropped shapes lights.
We print all long sleeve T-Shirts using the latest DTG print technology and highest quality inks to ensure a superior print quality and a lasting finish. This long sleeve round neck shirt is made from the highest quality cotton material to give the best fitting and comfort feel. 100% cotton for all shirt colours, except: Ash Grey is 99%, Sport Grey is 90%, Dark Heather is 50%.
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If you don't absolutely love it, we'll take it back!
If you're not happy with your order, please contact us as soon as possible. In all cases we'll ask you to provide photographs of the item, including a close up of any tags/labels. To help us respond to you quickly, please include the order number in your message to us.
We have a money-back satisfaction guarantee, so whatever the problem, we're happy to work with you to fix it.


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This is FRESH AIR. I'm Terry Gross. People often think of the brain as being like a computer. But according to my guest, neuroscientist Dean Burnett, that's only true if you imagine a computer that decided some information in its memory was more important than other information for reasons that were never made clear or a computer that filed information in a manner that didn't make any logical sense or a computer that kept opening your more personal and embarrassing files without being asked.
Burnett is the author of the new book "Idiot Brain: What Your Head Is Really Up To." It focuses on some of the more illogical behaviors the brain produces. He lives in Wales, where he's based at Cardiff University's Center for Medical Education and teaches in the psychiatry department. He writes the science blog "Brain Flapping" for the British newspaper The Guardian. Dean Burnett, welcome to FRESH AIR.
DEAN BURNETT: Thank you for having me.
GROSS: So in that analogy that you make between the brain and a computer, you say your brain would be like a computer that decided it didn't really like the information you'd stored. So the computer altered it for you – to suit your purposes, to suit your preferences. And you say your memory is egotistical – that the brain tweaks and adjusts the information it stores to make you look better. What's an example of what you mean there?
BURNETT: Well, I think the classic example is like someone claiming they caught a fish this big, holding their arms out. And oh, the obvious joke is that they didn't really. That's actually just exaggeration. But all of you will think that's just someone lying to try and look better.
But a lot of research suggests that we actually – whenever we remember something, we will tend to embellish if we're telling someone about it. We'll embellish it slightly to make us look a bit better. Or we'll make it a bit more impressive as a story. But every time you do that, the memory itself – it's got a good chance of itself being edited. It's being adjusted.
So the actual underlying memory is replaced by this updated version that you have created to convey something which makes you look better. And that seems to be happening constantly – that we think back on things and we sort of interpret them in different ways to make us feel better about ourselves – make us feel more accomplished, more involved, more capable and more important than we actually were. Because our memory is the only record of it, that often goes unnoticed.
GROSS: In writing about memory, you write about the difference between short-term memory and long-term memory. And short-term memory really doesn't hold very much. I mean, from how you describe it, it holds less than I even thought.
BURNETT: Yeah. That's sort of one of those mainstream ideas of how memory is structured and works, which is not quite correct – in that short-term memory – you see a lot of films and, like, TV shows. They sort of portray short-term memory as something from an hour ago or, like, that same day. Where it's actually – short-term memory is 30 seconds to a minute. Anything longer than that tends to actually now be officially a long-term memory 'cause it takes the brain…
GROSS: Whoa whoa whoa. Anything longer than a minute is officially long-term memory?
BURNETT: Essentially, yes.
GROSS: That means my long-term memory is worse than I thought (laughter).
BURNETT: Yeah. It's a strange – 'cause short-term memory is essentially patterns of activity in places like the frontal cortex. It's like a firework display. Or, like, I liken it to writing – like writing a shopping list in the foam on your coffee. You can sort of do it. And it's something that'll stay legible for a minute.
But generally, quickly, it'll fade away, whereas a long-term memory actually is, like, the neurons and the brain cells connecting together to form a new memory. But that takes time. That takes like 30 seconds to a minute for that to actually be achieved and the stories to actually happen.
So in the interim, we have this short-term memory, which is sort of holding the pattern just in place, waiting for the memory to be formed or for the information to be replaced. And that you can – you obviously know that happens a lot because when you sort of get up to go to the kitchen to get something, and then when you get there, you think, why am I in here now? – and then you have no – you can't remember why you came in there in the first place.
All you know is that you're there now. And that's, like, an example of a short-term memory being sort of lost rather than – it's stored – despite the fact that you actually have acted on it already.
GROSS: So I found this very interesting. You say in your book that there's evidence to suggest that nearly everything we experience is stored in long-term memory in some form. And here's why I find that interesting. This is the kind of thing that happens to me a lot. Like, one of our producers will come up to me and say, do you know that blah, blah, blah, blah, blah, blah, blah? And then I'll say, in all honesty, that sounds familiar. I don't know if I know that.
BURNETT: Yeah.
GROSS: And as my producer starts explaining, I slowly start to remember that yeah, I did know that. And I realize that I once knew this thing. Then I'd forgotten it. But there's still some kind of vague imprint of that memory in my mind. And the more I hear about it, the more the memory starts to resurface. Is that what you're talking about?
BURNETT: Yeah, that's quite a lot of evidence to suggest that there is different types of memory – something called familiarity and the difference between that and recall – 'cause with familiarity, it's like you say you know you know something. But you don't have any more information than that. All you know is that this has been encountered previously.
GROSS: Yes (laughter).
BURNETT: Yeah. So again, like, using the computer analogy – if you do a Google search, and then some things pop up and some of them are, like, already purple, it's – oh, I've been to that site before. You don't know what that site has on it. You don't know what it was for. It could be something dodgy. Maybe you were drunk at the time. I don't know. But you just know that you've been there before.
But it's when you actually open, like, the file or open the store that you actually understand what's going on in there. So it's the same – like the name thing again – or, like, when you meet someone and they have a very familiar face. You think, I know this person. I know – why do I know them?
And then they'll tell you some details and then fill in, say a few more things. And they'll say something. And you go, oh, yes. That's why – because at that point, there's enough familiarities occurred to sort of reach the threshold – the recall threshold – where it's not just knowing you have the memory. Now the memory itself is actually activated. And it all comes flooding back.
It's a very strange sensation of, like – oh, yes. And I remember all that. And they all – the actual memory itself is triggered 'cause enough familiarity happened. So the activity leading to that memory has gone past a certain point. And the whole thing is set off. And we have, like, the vivid experiences coming back to you. Oh, yes. I met him here. And then we did that. And that was 10 years ago – and so on, so on, so on.
So there are lots of – the brain has a good sort of rule of thumb for new and old. Like, that's a new thing. That's an old thing. That's a new thing. That's an old thing – because when you actually need the detail information itself, that's when you need to trigger the recall threshold, for want of a better description.
GROSS: OK. So the downside for me is I have a lot of memories that I will only remember if somebody tells me that information again. And then it'll start to surface. So on the downside, I've forgotten that memory. But on the positive side, once I hear it the second time, I think I'm more likely to remember it and keep it as a more permanent memory. Am I deluding myself or is that neurologically probable?
BURNETT: No. That makes perfect sense because we remember certain things and not other things. And that's sort of a constant problem because we'd like to remember the things – like if you're revising for a test or an exam. That's the stuff you want to remember.
But abstract information, which is just like intangible data – that isn't something the brain has really evolved to process. It can do it. But it's not its preferred form of information. It's more about experiences and things with a strong emotional attachment – any emotionally vivid memories like your first bike, you know, your first date with your partner, your wedding day. These are all things which have strong emotional resonance.
So they have a lot more attachments in the brain. Like, every single memory has lots of different links to it. So there are lots of different ways to trigger it. So if you have, like, an old memory which you don't actually – haven't really thought about. That's fair enough. So it's got a limited amount of connections to make it accessible. But then when you – no – are reminded of it by talking to a person, you go, oh, yes. So then it all comes flooding back.
That's a new sensation. That's – now you associate that memory with this experience of not being able to remember something and then remembering the person, then being happy that you remembered them. So, you know, you're forming lots of new connections to it. So that actually does make perfect sense in that the act of having a sudden, vivid recollection would, in fact, increase the likelihood that the memory will be more a bit more resilient from then on.
GROSS: If you're just joining us, my guest is neurologist Dean Burnett. He's the author of the new book "Idiot Brain: What Your Head Is Really Up To." Let's take a short break. And then we'll talk some more. This is FRESH AIR.
GROSS: This is FRESH AIR. And if you're just joining us, my guest is neurologist Dean Burnett, author of the new book "Idiot Brain." He's based at the University of Cardiff Centre for Medical Education, and he's a lecturer in psychiatry and writes a blog for The Guardian called "Brain Flapping."
So it's summertime, which means a lot of people are going on vacation, and a lot of those vacationers are going to be driving, many of them with children in the car. And I think children are especially prone to motion sickness. You have a very interesting explanation for why we can get motion sickness in a moving vehicle.
BURNETT: Yes. It's one of those things which people – it's such a common thing, I think a lot of people don't give it much thought. But when you think about it, moving shouldn't make us sick. We move around all the time. We're a very mobile species. So why – you know, why would moving suddenly make us want to throw up? And one theory is – and that's the most salient theory at the moment – is that it's caused by a sensory confusion in the brain and that when you're walking – you know, like us humans tend to do a lot – there's a lot of distinct signals being relayed to the brain that can – like the thalamus, where all the sensory information is put together and sort of, you know, fed to the other parts of the brain. So when you're walking, you've got this, oh, the left, right, up, down sort of sensation.
You've got the muscular system doing its thing and relaying all the signals to the brain. And you've also got the balance sensors in your ears, like, little tiny little tubes full of fluid. And the motion of that fluid tells us where we're going. So, like, if we're upside down, we can tell. And if we're going fast, we can tell because this fluid just obeys the laws of physics. And also, you've got your eyes, and the world's going past at a certain rate. All these things are sensory information which is fed into the, like, the thalamus area, which integrates all the sensory information together to give us an opinion or give us a view of what's happening in the world around us. So we think, oh, well I moving. This is good. That's what I should be doing. Excellent, all is well.
When you're in a vehicle – and vehicles aren't something we've really evolved to deal with because, obviously, they're a very, very recent addition to the world, and evolution takes a long time to catch up with anything. So when we're in a vehicle like a car or a train or a ship especially, you're not actually physically moving. Your body is still. You're sat down. Like, say you've got no signals from the muscles saying we are moving right now. Your muscles are saying we are stationary. And also your eyes – if you are sitting in a ship, like, you're looking at a static environment, so there's no information for the eyes to say we are moving. It's just, oh, everything is still.
But the fluids in your ears, they obey the laws of physics. And they are sort of rocking and around and sloshing because you are actually moving. So what's happening there is the brain's getting mixed messages. It's getting signals from the muscles and the eyes saying we are still and signals from the balance sensors saying we're in motion. Both of these cannot be correct. There's a sensory mismatch there. And in evolutionary terms, the only thing that can cause a sensory mismatch like that is a neurotoxin or poison. So the brain thinks, essentially, it's been being poisoned. When it's been poisoned, the first thing it does is get rid of the poison, aka throwing up.
And as a result – so, like, as soon as the brain gets confused by anything like that, it says, oh, I don't know what to do, so just be sick, just in case. And as a result, we get motion sickness because of the brain's constantly worried about being poisoned.
GROSS: Oh, and it is so incredibly not helpful – not your explanation, but…
GROSS: …The sickness.
BURNETT: No, it's…
GROSS: So….
BURNETT: …Inconvenient to say the least.
GROSS: So I think it's true that you're more likely to get motion sickness if you're reading in a moving vehicle, not an airplane? This is what I found to be true, just that queasy feeling. I know – like, when I was growing up, I could not read in a car. I could not read in a bus. But I could read in a train, and I could read in a plane.
BURNETT: Is that a Dr. Seuss book?
GROSS: (Laughter) Yes, yes it is.
BURNETT: (Laughter) Could you, could you, on a plane? Could you, could you in a train?
GROSS: (Laughter) So is there any – I'm assuming that this is a common experience, and it's not just me. But perhaps it's just me.
BURNETT: Well, it makes – again, given the explanation I provide, that does make perfect sense because you are – it's not just you're in the vehicle now. When you're reading a book, you are staring at something right in front of you, so you're shutting out a lot of external visual information. Now when you're in a car – a lot of people don't get motion sickness because the brain can effectively intuit this, though some people just are prone to it. It's just a quirk of development.
But you – when you're in a car, you can look out the window. You can see things going by. You can see the passage and movement itself, so that sort of balances the system. The brain's going, oh, look, things moving – I must be moving – and then sort of calms down the sickness response.
But when you're reading, you're looking at sort of a small, static square. And, you know, the external information which would say you're moving, that's shut out even more than it would otherwise be. And you're focusing straight ahead, and your vision's directed elsewhere. So it sort of increases the sensory mismatch, which is causing the sickness in the first place because you are sort of dead – you're looking at a fixed point. And you've got no visual information to try and help, you know, allay the brain's concerns. So yeah, that would make perfect sense.
GROSS: So I think a lot of people outgrow motion sickness. And is that because your brain, over time, adjusts to the mixed message that it's getting when the vehicle is moving, but your body is staying still?
BURNETT: That's probably what's happening, yeah? It's – children are – generally tend to be more prone to things like – which are involve, technically, the brain getting things wrong, things like sleepwalking. Children are far more prone to sleepwalking and things like that and motion sickness. That's because their brains are still developing. They're still being shored up. They're still being refined. They're still forming all the connections they will need for the rest of their lives.
And – this means their systems aren't so efficient yet. So gradually and over time, they will sort of lose the excessive part. They'll refine the more useful components. And as a result, like, the more – the less helpful things the brain does will sort of be slowly fading away because the brain becomes a bit more focused and a bit more refined and efficient over time as we age.
GROSS: So how much is intelligence based on having a good memory? Like, if you have a hard time remembering things you've learned, then you can't build on those things. You can't use those things to synthesize, you know, an analysis of, you know, a text or politics or whatever. So are memory and intelligence intertwined and dependent on each other?
BURNETT: Yes, to a certain extent. A lot of psychologists differentiate between two types of intelligence. There's crystallized intelligence, which is like things you remember, things you've learned and the information you have access to. So someone on a quiz show, for example, would be – you know, someone who's a champion of a quiz show, they would have very high crystallized intelligence because they can just remember all this information, all these facts and recall them at a moment's notice as and when they need to. So that's a very high crystallized intelligence.
But that's not the only element of intelligence. There's also something we call fluid intelligence. And that's the ability to apply the information, the ability to work with it, the ability to process it. So let's say Sherlock Holmes – like, he's presented with three different things. And he can go ah – put these things together. They show that the killer was there at midnight, and he had a brown dog.
And that's more like fluid intelligence because taking abstract information and processing it and working with it and applying it to the situation in front of you – so crystallized intelligence is, like, the information you have. Fluid intelligence would be your ability to use that information and extrapolate from it and to apply it in real world situations.
So the two are quite different in many ways. Like, fluid intelligence, a lot of research suggests, that declines as we get older just because our brains just age and become slightly less efficient over time with just general wear and tear, whereas crystallized intelligence doesn't seem to have any ceiling on it. It just keeps expanding as we get older, assuming, of course, our brains still keep working as they should and no new degeneration occurs.
GROSS: I thought it was the other way around – that your ability to synthesize things does not decrease with age, but your ability to just kind of, like, memorize things and retrieve facts does.
BURNETT: Well, a lot of people sort of claim that, yes. But a lot of the research suggests that it's actually the other way around in that you can – I think it's more a case of you can't stop remembering things. Like, you don't reach the age 65 and suddenly don't remember anything from that point on because, obviously, that's not what happens, unless you have some sort of serious disorder, of course.
But, anyway, you can carry on building up information over time. When you're 80 years old, you remember what happened yesterday or the day before. And you remember way to go, and you remember your appointments. So you can still build on the crystallized intelligence. It's just that the parts which process information tend to get a bit rusty. So that – according to the science, that's one argument anyway. But as I say in the book a lot, with most neuroscience claims and studies, you'll find another one which says the opposite pretty easily because it's a very confusing organ.
GROSS: Do you think of yourself as having a good memory?
BURNETT: I think I would say that I do have a good memory, but not for everything because, like, the brain does seem to have a tendency to specialize or to have preferences for the things it likes to remember in its process. Some people are better at maths. Some people are better at music and things, whereas I, too, I guess, tend to have a good memory for episodes of "The Simpsons" or jokes I've heard or people I've met recently and, like, anecdotes. But things like household organization and bills to pay, I tend to have a rather poor memory for these things as my wife will constantly tell me. So yeah, I have good memory in some ways and not in others.
GROSS: So you write a blog for The Guardian called "Brain Flapping."
BURNETT: Yeah.
GROSS: What's the most commented on post that you've written?
BURNETT: This – it came as a surprise the first time, but it shouldn't have in hindsight. I've written about a lot of things like trying to deal with some controversial subjects like transgender issues – that was quite a hot-button one and immigration, whether it's good or bad; and same-sex marriage got a lot of responses. But the most controversial post I did in terms of the most angry comments I got was whether or not you should put milk in your tea before the water or after.
GROSS: (Laughter).
BURNETT: That is such – it was the most British thing you'll ever hear, I know. But that is like – that was the most – even my parents got involved in that one, which they never normally do.
GROSS: Wait. So what was your argument?
BURNETT: Well, there's a study which says you should put milk in first, but that actually only applies to if you use it from a teapot in a sort of bone china cup because, obviously, it takes the heat off the tea so the cup doesn't fracture. But if you use a mug, then it's a different process, and it went down into the chemistry of it. And it came down to the fact that you should put it first or last, depends on how you like it because it's all about taste perception and the ritual and the psychology behind it.
But that diplomatic copout wasn't enough for some people. They decided that I should hear, in no uncertain terms, how wrong I was.
GROSS: So which do you do?
BURNETT: Me, I put milk in second actually. But I might actually be kicked out of the country for this, but I can't tell either way. And that's not something a British person wants to hear. But yes, I'm not actually fussed either way. I can take it both ways.
GROSS: Nice to know that tea is click bait in England.
BURNETT: (Laughter) Very much so.
GROSS: Dean Burnett, thank you so much for talking with us.
BURNETT: No problem at all. Thank you very much for having me, Terry.
GROSS: Dean Burnett is the author of the book "Idiot Brain: What Your Head Is Really Up To." He writes the science blog "Brain Flapping" for the British newspaper The Guardian. After we take a short break, we'll hear from comic Ali Wong whose comedy special is frank and funny on subjects ranging from being Asian-American to her sex life and being pregnant. I'm Terry Gross, and this is FRESH AIR.
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Category:John T. Williams Memorial Totem Pole
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Note that under U.S. law, the totem pole itself is considered a sculpture, and there is no freedom of panorama for sculptures. Any image of the pole itself would require the explicit permission of John T. Williams's brother Rick Williams, designer and principal carver of the totem pole.
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Want to have your headlight retrofitted but don't want to do it yourself? We from Retrofitlab also offer Retrofit service! How does it work? First contact us and let us know the whishes for your retrofit. Then disassemble your headlights yourself or let your dealer do it for you, and send the headlights to us with parcel post. Or you can drop them at our office in Ermelo, Netherlands. Within 2 days your headlights are finished and they will be shipped back to you, or you can come and pick them up yourself.
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4 Juniper Court,Newtown PA, 18940
Sold Price
3 beds , 2 Full/1 Half baths
2,033 sq. ft
Status: Sold
Berkshire Hathaway HomeServices Fox & Roach, REALTORS
(866) 486-5636
Last Updated: 2/25/2017 12:25 PM
Description for 4 Juniper Court Newtown, PA 18940
Fantastic location! Rare end unit and quiet Cul-De-Sac location backing up to beautiful trees and peaceful open space. Large back, side and front yard with in-ground fence system and large EP Henry patio. This spacious Yardley Deluxe is designed with an open and sweeping floor plan with over 2,033 square feet of living space. Freshly painted inside, new carpet in Great Room and second bedroom. New range, newer replacement windows downstairs and newer shingled roof. First floor featuring Living Room, Dining Room, Eat-In Kitchen, Great Room with cathedral ceiling skylights, wood burning fireplace and sliding Anderson glass doors leading out to patio. Laundry Room with door to a one-car garage with overhead storage area and large closet. Second floor featuring spacious MBR suite, W/I closet, sitting area, master bath with new full-size stall shower and jetted tub. Plus two additional nice size bedrooms and full size bath in the hallway. Association allows you the use of all recreational facilities offered by Newtown Grant including swimming pool with clubhouse, tennis, basketball, volleyball and more! Award winning Council Rock schools. Close to historic Newtown Borough featuring shops, restaurants, malls and easy access to I-95 (NYC/PHIL)Police and Fire Departments right across the street. One-year Home Warranty. Come see!
Listing Information
Newtown Grant
Gas Water Heater, Public Water Service
Public Sewer
School Information
Room Information
First Floor Laundry
Interior Features
Central Air, Ceiling Fan(s)
Gas Heat, Forced Air
No Basement
Skylight, Cathedral/vaulted Ceiling
Exterior / Lot Features
1 Garage Spaces, 2 Parking Spaces, Attached Garage, Driveway
Shingle, Pitched
Street Lights, Front Yard, Back Yard, Side Yard, Cul-De-Sac, End Unit
Community Features
Community Pool, Community Tennis
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Current market conditions for 4 Juniper Court
Active Market Trends
Source:MLS DATA
Median list price$639,497
Days on market114
Properties for sale98
Sold Market Trends
Source:MLS DATA
Median sold price$380,000
Sales to list price9,674.0%
Properties sold92
Median sq ft price$179
Arrows indicate 90 day trend
Listing Price History for 4 Juniper Court
Newtown Real Estate
Newtown is located in Pennsylvania. Newtown, Pennsylvania 18940 has a population of 2,494.
The median household income in Newtown, Pennsylvania 18940 is $67,484. The median household income for the surrounding county is $76,859 compared to the national median of $53,046. The median age of people living in Newtown 18940 is 45.7 years.
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Envirocool North West
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For many years now, EnviroCool have been offering advanced expertise in the field of Air Conditioning. We have worked with many big brand names throughout Southport and the surrounding Merseyside areas, where we have had the pleasure of fitting our top quality air conditioning systems in homes and workplaces alike.
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Tampa is located in Hillsborough county and has a population of 303,447.
MSN schools in Tampa charged students an average tuition of $13,050.00 if they were Florida residents, and $14,666.00 if they were non-residents, during the 2009 - 2010 school year.
The average cost of books and supplies for msn schools in Tampa is $1,144.00. Students living on campus at msn schools in Tampa paid an average of $8,078.00 for room and board during the 2009 - 2010 school year. Students living at home incurred costs of $4,926.00. There are five msn colleges in Tampa for students to choose from. 797 students were reported to have graduated from msn programs in Tampa in the 2008 - 2009 school year.
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UK franchisee stories
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Sophie Harker had previously worked as a property manager before deciding to become her own boss with EweMove. Although you do not need any previous estate agency experience, Sophie still benefited from all the training and support she received so as to confidently launch, build and manage her franchise. To find out if this route into business-ownership might also suit you... Read more..
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Since starting his Student Letting Agency business in 1998, Nicholas Humphreys has since expanded into the Professional Lettings market and, thanks to his proven business formula, there are now 25 offices nationwide. Nicholas is kept busy supporting the Rainbow Children's Hospice, his own property investment company, as well as a family with three children. Find out what makes a successful, ethical franchisor…Read more..
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Business leaders including BP's Tony Hayward, Virgin's Sir Richard Branson, and Sir Martin Sorrell, founder of the advertising group WPP, will converge on Copenhagen today for the World Business Summit on Climate Change.
The event, which will also be graced by actress Cate Blanchett and former US vice-president Al Gore, is one of several being held in the lead-up to a key conference in November, also in Copenhagen. This week's two-day event will look to address ways to cut carbon output.
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Can a gluten free person get a good meal at this restaurant?
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We went during CNY, despite the crowd..the cendol taste not as good as last time. It might be due to the busy traffic orders. And the stalls are now moved inside instead of out.
I have been coming here for the past 10 over years and it WAS a great place to drop by for the Laksa n Cendol....Unfortunately....it became a little commercialized in recent years and now the food quality has dipped and the prices has risen. I dont think i will suggest this place for some time now
This place is overrated. The food is average, expensive, and service is terrible. You can get much better taste at other places with lower prices. No one manages the queue. Some people might just cut your queue, so beware. Staffs picking up dishes and manning the cashier are all rude. Overall, it was an unpleasant experience.
Best place, one and only if you want Cendol dessert. Don't waste time and money on other places. Nothing beats 88 Jonker.
Same goes for Assam Laksa. The best in Jonker.
Short para says it all - go try it for yourself! You will be glad on not wasting your tummy on the inferior stalls!
Love it.love it.love it.can't tell you how good the food+ dessert here. Should try the laksa kahwin and classic sagu gula melaka dessert.
I am sure other food also delicious or in Malay, SEDAP!
Located in the middle of jonker street.
Easy to find.
Crowded with people and cheap price.
Exotic atmosphere.
Try local food Nonya laksa and Baba laksa.
Many people but not sure nice or not . Hopefully is good. I think kacang durian is good.
See this ..........
For me... a trip to Malacca will never be accomplished without a meal here.. 😆
Get there earlier..before the lunch hour begins otherwise you'll be queuing in the heat 😄
Reasonably priced.. various kinds of local noodles..dishes.. mouth watering desserts.. just yummy !!
We ordered the rojak, durian chendol and laksa kahwin, which is a combo of both the assam and baba laksas. Laksa was delicious - good start, I thought. But I was wrong.
The rojak was not the rojak buah (mixed fruit/veg) we expected, but the savoury rojak sotong kangkung. Tasted a bit weird but was told this is how melaka...
packed eatery with lots of tourists and locals. Was a bit of a struggle getting a seat, but we got a table eventually after 10 mins. Had he laksa and chendol. Food was average and a little underwhelming
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is this place serving halal food?
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Hotfrog INDIA provides information regarding Aspra Industries in New Delhi. Aspra Industries is located at 210, Suneja Tower-II Janakpuri District Centre, New Delhi New Delhi 110058 and provides Pipes services. Contact them by visiting them on their website http://www.aspraindia.com.
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CIVIL LINES NEW DELHI New Delhi 110054
PATEL NAGAR (E) NEW DELHI New Delhi 110008
M G ROAD SULTANPUR NEW DELHI New Delhi 110030
KALKAJI NEW DELHI New Delhi 110019
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Watch Remember the Titans Online
|Remember the Titans (2000)
|Rating: 7.8/10 (160,547 votes)
Director: Boaz Yakin
Writer: Gregory Allen Howard
Stars: Denzel Washington, Will Patton, Wood Harris, Ryan Hurst
Runtime: 113 min
Rated: PG
Genre: Biography, Drama, Sport
Released: 29 Sep 2000
|Plot: The true story of a newly appointed African-American coach and his high school team on their first season as a racially integrated unit.
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Infections with Campylobacter spp. pose a significant health burden worldwide. The significance of Campylobacter jejuni/Campylobacter coli infection is well appreciated but the contribution of non-C. jejuni/C. coli spp. to human gastroenteritis is largely unknown. In this study, we employed a two-tiered molecular study on 7194 patient faecal samples received by the Microbiology Department in Cork University Hospital during 2009. The first step, using EntericBio® (Serosep), a multiplex PCR system, detected Campylobacter to the genus level. The second step, utilizing Campylobacter species-specific PCR identified to the species level. A total of 340 samples were confirmed as Campylobacter genus positive, 329 of which were identified to species level with 33 samples containing mixed Campylobacter infections. Campylobacter jejuni, present in 72.4% of samples, was the most common species detected, however, 27.4% of patient samples contained non-C. jejuni/C. coli spp.; Campylobacter fetus (2.4%), Campylobacter upsaliensis (1.2%), Campylobacter hyointestinalis (1.5%), Campylobacter lari (0.6%) and an emerging species, Campylobacter ureolyticus (24.4%). We report a prominent seasonal distribution for campylobacteriosis (Spring), with C. ureolyticus (March) preceeding slightly C. jejuni/C. coli (April/May).
Campylobacter-related gastroenteritis is one of the most common causes of acute bacterial diarrhoeal illness in both developed and developing countries (Coker et al., 2002). There is a persistently high incidence of campylobacteriosis in European countries, and the 2007; crude incidence rate in Ireland was a direct reflection of the European average of 45.2/100 000 (HSPC, 2007; EFSA, 2009). National surveillance programmes which have been employed by many industrialized countries have contributed to improved reporting of Campylobacter infections (HSPC, 2007). Yet despite the high reported incidence it is estimated that the true rate of infection may be between seven and thirty times higher (Crushell et al., 2004; Moore et al., 2005; Janssen et al., 2008).
Campylobacteriosis is primarily regarded as a zoonosis and the reservoirs for infection vary depending on the species, but encompass a wide range of birds, livestock and domestic animals (McClurg et al., 2002; Moore et al., 2005). To date, 26 species are assigned to the Campylobacter genus (Euzeby, 1997), however, only some of these have been linked with human gastroenteritis (Mandrell et al., 2005; Moore et al., 2005). Campylobacter jejuni and Campylobacter coli combined have been reported as accounting for at least 95% of Campylobacter isolations in humans with gastroenteritis (Kulkarni et al., 2002; Moore et al., 2005), when using traditional culture methods for diagnosis. Advances in molecular diagnostics facilitate detection of non-C. jejuni/C. coli spp. from clinical samples (Duffy et al., 2007; Bullman et al., 2011). However, to date, the true contribution of non-C. jejuni/C. coli species to human gastroenteritis remains unknown, and the aims of our study were to determine the proportion of non-C. jejuni/C. coli Campylobacter in faeces from patients with acute gastroenteritis, and to analyse the complete collection of results with regard to seasonality and age distribution.
In this study we employed a two-tiered molecular-based analysis to examine the distribution of Campylobacter spp. in patients presenting with diarrhoeal illness for the calendar year 2009. The first stage of the investigation was to detect a genus-specific marker for Campylobacter spp., and the second stage sought to determine identity to species level.
Materials and methods
Patient samples
A total of 7194 faecal samples collected over a 1-year period, from patients presenting with diarrhoea were screened for Campylobacter spp. using EntericBio® (Serosep Ltd, Limerick, Ireland). Of these, a total of 349 DNA samples were included in the study. These samples, stored at −20 °C, were extracted from anonymized faecal samples that tested positive for Campylobacter genus using the EntericBio® system. The samples were received by the Department of Medical Microbiology at Cork University Hospital, Ireland, between January 2009 and December 2009.
Control strains
The following control isolates were used in the study: Campylobacter jejuni ssp. jejuni DSM 4688, Campylobacter coli DSM 4689, Campylobacter lari ssp. lari DSM 11375, Campylobacter fetus ssp. fetus DSM 5361, Campylobacter upsaliensis DSM 5365, Campylobacter hyointestinalis ssp. hyointestinalis DSM 19053 and Campylobacter ureolyticus DSM 20703. All control strains were obtained from DSMZ, Braunschweig, Germany.
PCR template preparation
DNA was extracted from the faecal samples using the EntericBio® system in accordance with the manufacturer's instructions. The extracted DNA samples were either used immediately in the EntericBio® system or stored at −20 °C for subsequent use in Campylobacter species-specific and genus-specific PCR.
PCR assay
The 349 Campylobacter genus positive DNA samples were investigated using uniplex species-specific PCR assays for C. jejuni, C. coli, C. lari, C. fetus, C. hyointestinalis, C. upsaliensis and C. ureolyticus, respectively, according to the methods used by Bullman et al. (2011).
S rRNA gene sequencing
A Campylobacter genus-specific PCR targeting the 16S rRNA gene was conducted on DNA samples that were negative for species-specific PCR. Samples that produced a PCR amplicon were subject to 16S rRNA gene sequence analysis (Eurofins MWG Operon, Ebersberg, Germany). Returned sequences were subjected to blast analysis using the NCBI database and aligned by the clustalw method in Megalign from the Lasergene suite of programs (DNAstar). Clinical strains were considered to be identified when sequence similarities with GenBank entries exceeded 99% identity over the entire length of the sequence.
Data collection
On receipt of the samples in the Microbiology Laboratory, each patient sample was assigned a unique specimen record number and the samples were anonymized for the purposes of this study. Details of the patients' age and gender along with sample details and collection information were provided on patients who were confirmed Campylobacter-positive, from which age and gender profiles were constructed.
Confirmation of EntericBio® positive Campylobacter spp. results
Of 7194 patient faecal samples submitted to the Microbiology Laboratory from January to December of 2009, a total of 349 samples were determined to be Campylobacter genus-positive by the EntericBio® molecular method. Campylobacter species-specific PCR confirmed the presence of Campylobacter spp. in 329 (94.3%) of the 349 EntericBio®-positive samples. Of the 20 samples which were Campylobacter-positive by the EntericBio® but negative for the species-specific PCR, nine samples were positive for the Campylobacter genus-specific PCR (targeting the 16S rRNA gene); however, these samples failed to return results on sequencing. A further two samples were negative for the 16S rRNA gene PCR but were recorded as Campylobacter culture-positive by the clinical Microbiology Laboratory; thus, these 11 samples were reported as non-speciated Campylobacter positives. A total of nine samples were negative for both Campylobacter species-specific and genus-specific PCR and were reported as Campylobacter culture-negative by the clinical Microbiology Laboratory; thus, these nine samples were recorded as false positives. A total of 340 samples of the 349 patient samples which were positive by the EntericBio® molecular method were confirmed by alternative molecular methods (species-specific or genus-specific PCR) and/or routine culture to be true Campylobacter spp. positives.
Speciation of Campylobacter-positive samples
Campylobacter spp. were identified in 329 patient samples by species-specific PCR. There were 373 Campylobacter detections in all, as 33 samples contained mixed infections involving a total of 77 Campylobacter detections. Figure 1 shows the contribution of each species to the total number of organisms detected. The most common species, C. jejuni, was detected in 246 (72.4%) of patient samples and accounted for 66% of the total detections. Campylobacter ureolyticus was detected in 83 (24.4%) patient samples, accounting for 22.3% of the total detections. Campylobacter ureolyticus was the sole Campylobacter species detected in 55 (16.7%) patient samples (95% confidence interval: 12.8–21.2%). Campylobacter coli accounted for 6.7%; present in 25 (7.1%) of patient samples. Collectively C. fetus, C. hyointestinalis, C. upsaliensis and C. lari amounted to 5% of the total detections.
Age and gender distribution of Campylobacter- positive patients
Age and gender profiles were constructed (Fig. 2) for the 340 patients confirmed as Campylobacter positive; 52.4% were men. A bimodal age distribution was noted in both genders (Fig. 2); 51.8% of all Campylobacter detections were distributed between two age groups; children under 5 years (31.1%) and adults over 70 years (20.7%). In male patients, Campylobacter infection was commonest in those ≤ 5 years (37%), whereas in female patients, it was most frequent in those ≥ 70 years (29%) (Fig. 2). Infection remained at lower levels between late childhood and the 66–70 age group with the exception of a peak in male patients aged 41–45 (10.8%).
The age and gender profiles for C. ureolyticus exhibited a similar bimodal profile to those observed for the combined species, presenting peaks at extremes of age. This species was more commonly detected in female patients (62.7%) and more than 50% of detections in female patients were in the ≥ 70 age group (Fig. 2).
Seasonal prevalence of Campylobacter 2009
The hypotheses that the incidence of C. jejuni/C. coli and of C. ureolyticus is uniformly distributed across the 12 months were conclusively rejected by the chi-square goodness-of-fit test, showing P-values of 0.000, and 0.003, respectively).
As shown in Fig. 3, C. jejuni/C. coli infection peaked in April and May (12.9% and 12.6% of the total, respectively), declined from September onwards and remained low during the winter months.
An abrupt peak was observed for C. ureolyticus infections in early spring; 18.1% of the total number of detections occurred during March. The fewest detections of C. ureolyticus infections (2.4% of the total) were observed in December.
Campylobacter infections remain a significant public health issue, not only in terms of morbidity but also economic cost. In 2006, a total of 175 561 confirmed cases of campylobacteriosis were reported from 21 European countries (EFSA, 2009), a figure which is thought to be an underestimate (Moore et al., 2005; Janssen et al., 2008). Furthermore, the annual cost of Campylobacter infection in the US is estimated to be at least $8 billion; a large economic burden (Crushell et al., 2004). Based on routine culture detection in diagnostic laboratories, C. jejuni and C. coli have been reported as being the most prevalent Campylobacter spp. causing human disease and, as a result, the majority of Campylobacter research has focused on these two species. With recent advances in diagnostic methods, there has been an increasing realization of the limitations of routine culture for the detection of non-C. jejuni/C. coli spp. (Lastovica & le Roux, 2000; Maher et al., 2003; O'Leary et al., 2009; Bullman et al., 2011). Thus, traditional culture underestimates the true occurrence of both Campylobacter-related gastroenteritis and also the emerging campylobacteria that are detectable by molecular methods in cases of gastroenteritis (Lastovica & le Roux, 2000; Maher et al., 2003; Bullman et al., 2011). Herein, we employed a two-tiered molecular detection method, independent of culture, for the direct detection of Campylobacter spp. from the faeces of 7194 patients presenting with diarrhoeal illness.
Of 340 Campylobacter-positive samples, C. jejuni represented the largest proportion of PCR-positives, present in 72.4% of patients; although it has previously been reported that this species accounts for at least 80–90% of Campylobacter-related infections (Kovats et al., 2005; Moore et al., 2005). Campylobacter coli, traditionally ranked as the second most common Campylobacter species found in Campylobacter enteritis (Coker et al., 2002; Moore et al., 2005; Ivanova et al., 2010); was identified in 7.4% of samples. An emerging species, C. ureolyticus, was detected in 24.4% of cases, and was detected solely (without other bacteria or viruses) in the samples of 55 symptomatic patients. There are a number of reasons why C. ureolyticus fails to be identified by routine culture: it is incapable of growth under the microaerobic atmosphere conditions used (5% O2, 10% CO2 and 85% N2) unless hydrogen is supplied. In addition, certain strains appear to be sensitive to the antibiotic used in the Campylobacter selective agars. Finally, most clinical laboratories isolate Campylobacter from stools at incubation temperatures >40 °C; however, C. ureolyticus fails to grow above 37 °C (Vandamme et al., 2010). To our knowledge, this is the first report of C. ureolyticus replacing C. coli as the second most common Campylobacter species in patients presenting with diarrhoeal illness. Furthermore, as previously reported (Bullman et al., 2011), given that only 1.15% of the 7194 samples processed contained this organism, it is unlikely that C. ureolyticus exists as a common commensal in the gastrointestinal tract.
In support of the findings of Maher et al. (2003), we determined that non-C. jejuni/C. coli spp. accounted for 27.4% of the total Campylobacter organisms detected; a much greater percentage than the previously reported 1–5% (Galanis, 2007; Ivanova et al., 2010). The large proportion of non-C. jejuni/C. coli species in this study is primarily due to the novel identification of C. ureolyticus, which as mentioned previously, is not normally isolated by routine Campylobacter culturing techniques. This finding highlights the advantages of molecular diagnostics for the detection of such fastidious organisms. Recent observations by O'Leary et al. (2009), when comparing a multiplex PCR assay to routine culture indicated that approximately 30% of samples positive for Campylobacter by the molecular method failed to grow on culture. Similar results were reported by Bessède et al. (2011), who reported considerably lower sensitivity for culture-based techniques compared to molecular methods. The hypothesis that the true proportion of Campylobacter detections due to C. jejuni/C. coli is 95% or more in the current study is conclusively rejected by the appropriate statistical test (P-value = 0.000).
The reported incidence of the less commonly grown campylobacteria varies in different regions of the world (Moore et al., 2005), and interestingly, we have detected C. fetus in 2.4% of the Campylobacter-positive samples (0.11% of the 7194 samples analysed). Campylobacter fetus has been considered to be a very rare cause of gastroenteritis in humans and acts most often as an opportunistic pathogen in immunocompromised individuals (Umehara et al., 2009); our findings may suggest the need for further investigation of this species as a gastrointestinal pathogen.
Human Campylobacter infection in temperate countries has been acknowledged as having a seasonal occurrence. Reports demonstrate a trough during winter months followed by a two- to threefold higher peak in late spring or early summer (Kovats et al., 2005). Our findings reflect this for the combined Campylobacter spp. as well as for C. jejuni/C. coli and C. ureolyticus individually. Campylobacter jejuni/C. coli and C. ureolyticus infections peak in spring. Figure 3 suggests a slightly earlier peak (March) for C. ureolyticus in comparison to C. jejuni (April and May).
A second epidemiological feature of Campylobacter infection is that incidence shows associations with patient age and gender (Crushell et al., 2004). European studies report (HSPC, 2007, EFSA, 2009) that in developed countries Campylobacter infection is most common in children under 5 years; however, a second peak is noted in the young adult, the 15–24 year age group, which is not observed in developing countries. In our study, Campylobacter was most frequently detected in the extremes of age, with more than half of all detections in children ≤5 years and adults ≥70 years. Campylobacter ureolyticus was shown in this study to be more common in female patients. Previously, Campylobacter infections have been reported as more common in male patients (Moore et al., 2005; EFSA, 2009). In addition, the peak which we report in the elderly (particularly for C. ureolyticus) accords with a recent study in the UK (Gillespie et al., 2009), which found that the elderly are the population most at risk of Campylobacter infection.
In conclusion, the results of our investigation for the period of January–December inclusive, 2009, in Southern Ireland, suggest that non-C. jejuni/C. coli spp. contribute considerably to the proportion of Campylobacter-positive samples from patients presenting with diarrhoeal illness. This finding illustrates the power of molecular-based detection over less sensitive culture techniques (O'Leary et al., 2009; Bullman et al., 2011). The resulting positive impact of increased sensitivity of diagnostics on clinical care is likely to be significant. Although Campylobacter-related gastroenteritis is usually self-limiting in the immunocompetent host, it imposes a high economic burden primarily due to hospitalization and man hours lost to industry. As Campylobacter infections are notifiable in Ireland, increased sensitivity of detection might be expected to heighten infection control efforts, in particular for organisms such as C. ureolyticus, whose reservoir is currently unknown.
We acknowledge the assistance of Mr John Murphy, Department of Biological Sciences, Cork Institute of Technology. S.B. is supported by a scholarship from the Irish Research Council for Science, Engineering and Technology (RS/2009/1670). R.D.S. is an ESCMID Fellow. Funding was provided by Serosep Ltd, Ireland. The authors declare that they have no competing interests.


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Today's Featured Artist: Michael Godard
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Leonardo Digenio 28 Days Ago
Stunning piece, Stan! I am following you. Liked and Favorited.
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The 18x18 original has been sold but a duplicate 3D copy at other sizes can be ordered on commission. Contact me to order. This is one of five unique single floral 3D relief collages. The work is created first by scanning actual flowers. In Photoshop, the composition is organized on screen, multiple layers created, variations introduced, and then the final image is printed as giclees onto canvas twice. The first canvas print is stretched onto typical wood stretcher bars. With the second canvas print the flowers are cut out to extend beyond the frame edge, glued onto the first canvas layer and onto wood blocks which are cut out and attached to side edges to support the extended flowers. See the video on the web site to get more info. http://www.stanbowman.com/
DIGITAL ABSTRACTS. These are from iPhone pics which are then opened in other apps on an iPad to make multiple transformations and other changes . FLORAL PHOTOGRAPHS. These are from actual flowers scanned on a flatbed scanner. In Photoshop they are separated into layers and arranged over a specially created background. LANDSCAPES. These are scenes primarily�in the New York, Massachusetts, and eastern US areas, showing the grandeur of the natural landscape, its amazing colors and shapes. I have been an artist since the 1950's starting with photography, beginning with black and white photographs of interesting places like Point Lobos, CA and White Sands, NM. In the 1970s having learned to do color photography I moved on to...
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The removal of the parathyroid glands generally leads to early death preceded by very characteristic nervous and muscular disturbances described under the name of tetany. Various attempts have been made to bring this pathologic phenomenon into a causal relation to a deficiency in calcium in the circulating fluids. Removal of the glands has been alleged to be attended with a loss of calcium, on the one hand, and the injection of salts of this element has repeatedly been demonstrated to suppress the tetany symptoms in affected animals. It is quite conceivable, however, that such an effect of introduction of calcium is due to a sedative action instead of a restoration of an element which may be assumed to be available in abundance in an organism possessed of a bony skeleton.
Experimental investigations in the department of pathology at Columbia University, New York, have attacked the question of the relation of
CALCIUM AND PARATHYROID TETANY. JAMA. 1915;LXIV(5):441. doi:10.1001/jama.1915.02570310061026
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Blowfish Grants Ballet Flat
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Play at CSUF ties up some 'Loose Ends'
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Ara Agopian - Resume
To apply my creative expertise in the graphic arts; utilize my broad
knowledge of software and design techniques.
AA GRAPHICS - 7/05 to present
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GKDI - 12/04 to 7/06
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FORREST K HAAG, ASLA, INC. - 2/01 to 12/04
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Bachelor of Arts, Art - California State University Long Beach
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Academic Associate Degree, Graphic Design - Los Angeles Pierce College
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I start full time work next week and have to put my 2.5 year old and 4 month old into daycare. I am going back to work full time out of necessity rather than choice. I am a mess. Every time I think about not being with my baby I start to cry. I'm so upset that I won't be there for her and that she will spend more time with someone else than with me. I'm not as worried about my 2.5 year old because I think he will love daycare and it will be good for him. I am a kindergarten teacher so they will be at the same centre as me so I am a lot luckier than some other mothers but this is not making it any easier.
Is this crying normal? Did other mothers go through this? I am dreading my first day at work cause I know I will cry in front of my new workmates. I just want the crying to stop. I don't want to be upset in front of my kids either.