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Questions for post-graduate surgical exams
This project was successfully completed by Muzammil196 for $495 USD in 30 days.Get free quotes for a project like this
Project Budget$30 - $250 USD
Completed In30 days
Total Bids4
Project Description
I am looking for qualified doctors to write practice questions for UK post graduate surgical exams. For this project, I am looking for sets of 150 questions at the level required for MRCS Part 1. A detailed syllabus will be provided to enable structured coverage of topics.
Questions must be in a 'best of five' format, where after the initial question of 20-100 words, 5 options are presented for the candidate to choose from. Only one of these options is correct, but all should be plausible to a candidate with a low level of knowledge. An explanation of 80-200 words must then follow and discuss correct and incorrect answers. 30 questions must be accompanied by an original image or table. Images sourced from the internet must be fully referenced and visually non-complex. Please do not include photos, radiology images or other patient orientated images. Further details on question style are available in the attached file and on request.
If you are interested in bidding for this project, please state the qualifications and experience that you feel make you suitable for this work. Also, please provide a sample question. Payment will be made on completion of the project, with a single milestone payment available on delivery of the first 75 questions.
All submissions will be analysed with plagiarism software that scans both online and traditional publications. Only original work will be accepted.
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- Forbes
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- Time
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- Times Online


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Information Builders' Tools Now Put More Analytics in Users' Hands
The business intelligence software maker is putting more analytics in the hands of end users with guided data discovery, a responsive portal for practically all device classes and Apple Watch support.ORLANDO, Fla.—Celebrating its 40th year, New York-based business intelligence specialist Information Builders announced today new updates and enhancements to its software platforms that the company expects will pave the way for another 40 years of helping knowledge workers glean business-boosting insights from their company data. One of the most enabling new capabilities is an Auto Linking feature in WebFocus, the company's BI and analytics platform, which bridges the gap between disparate analytical content for users and avoids a repeat of the "Excel hell" for enterprises seeking to move past spreadsheet-based BI, Jake Freivald, vice president of corporate marketing for Information Builders, said here. In a typical organization, developers are approaching business analytics independently of one another, with little thought to how users are expected to connect the dots. "Some are developing reports, some are developing a portal, and some are reporting some kind of visualization. No end user should know or care that there are different developers developing those things," Freivald told eWEEK. Users are then left to pull data and manage it themselves using self-service tools. Instead of leaving workers to their own devices, Auto Linking provides a guiding hand. Working off the WebFocus platform's inherent visibility into what developers are doing, Auto Linking surfaces relevant visualizations, reports and other analytical data related to their queries.
"WebFOCUS Auto Linking is the industry's first technology to automatically provide this capability for all enterprise data elements, and we're excited to bring the benefits to our global customer base," said Information Builders CEO Gerald Cohen, in a statement. "The technology underscores the power of having one unified platform, as it allows organizations to maximize data exploration without IT support or prior analytics knowledge."
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subset: commoncrawl


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A widget that pulls a Zazzle feed and displays products based on a query
This widget provides a nice, optionally thumbnailed list of Zazzle products based on query parameters you configure it with, including the store, search terms and sorting mechanism. Unlike other Zazzle widgets, this one only uses the referral identifier that you give it, or none at all if you do not specify one (you know who you are -- wink).
Additionally, this widget can be embedded into your posts and pages with a
shortcode. These shortcodes look something like
[pizazz query=asparagus rows=8
I use PCRE to parse the RSS feeds. If Pizazz does not work, make sure that PCRE is available in your PHP installation. It is available on most PHP servers.
Pizazz is multisite-compatible!
NOTICE: I don't have a testing staff, and my ability to think of every potential problem is limited. If you have problems make sure to report them to me or I won't know they exist for a long time!
Requires: 3.4.2 or higher
Compatible up to: 3.5.2
Last Updated: 4 years ago
Active Installs: 300+
Got something to say? Need help?


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More Videos...
Corvette C5 Z06 0-60 mph
Trying to beat the factory 0-60 time of 3.9 seconds in my 2002 Z06. Don't think I got it, maybe I'll try again without bogging the launch or being slow and early on the 1-2. Sorry for the shaky camera, people are right when they say how tricky it is to drive, shift, steer, and hold a camera without killing themselves.
ZR1 & Z06 - 150mph acceleration
Some random footage I had of a ZR1 and some Z06 Vettes with views of the speedometer. The ZR1 view shows how fast it can get to 150mph. Check out http://www.hightechcorvette.com Follow us on Facebook http://www.facebook.com/hightech.corvette
INSANE 150 MPH CRASH! 800 hp Corvette Crashes Street Racing
Intense in car video of a 150 mph wreck, thankfully everyone walked away with scratches and bruises. Forum - http://www.thirdhonk.com/community/index.php Facebook - https://www.facebook.com/thirdhonk/


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Strawberry Ice Cream
|Unflavored gelatin
|1 Tablespoon
|Cold water
|1⁄4 Cup (4 tbs)
|Egg yolks
|2 , well beaten
|1⁄4 Teaspoon
|1 1⁄2 Teaspoon
|Crushed strawberries
|2 Cup (32 tbs) (Fresh)
|Heavy cream
|2 Cup (32 tbs)
|Egg whites
|1⁄4 Cup (4 tbs)
Soften gelatin in cold water; dissolve over hot water.
Combine next 6 ingredients; add gelatin; mix well.
Pour into 2-quart refrigerator tray; freeze firm.
Beat egg whites till soft peaks form; gradually add 1/4 cup sugar, beating till stiff peaks form and sugar is dissolved.
Break frozen mixture in chunks; beat till fluffy with electric mixer (or partially freeze; beat with rotary beater).
Fold in egg whites.
Return quickly to cold tray; freeze firm.
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 216 Calories from Fat 164
% Daily Value*
Total Fat 19 g28.7%
Saturated Fat 11.3 g56.7%
Trans Fat 0 g
Cholesterol 102.8 mg34.3%
Sodium 81.4 mg3.4%
Total Carbohydrates 9 g3.1%
Dietary Fiber 0.7 g2.8%
Sugars 6.9 g
Protein 4 g7.2%
Vitamin A 15.1% Vitamin C 34.9%
Calcium 4.2% Iron 1.5%
*Based on a 2000 Calorie diet


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More Videos...
2001 TransAm with MS4 cammed, headers, exhaust w/ cutout, lifters, pushrods, springs
walk around of a nice 2001 TransAm with MS4 cammed, headers, Exhaust w/ cutout, lifters, pushrods, springs. This thing is loud and my DD, I love the big cam and wouldent go with anything smaller... thanks for watching.
MS3 Cam WS6
CAR IS FOR SALE: https://post.craigslist.org/manage/5050591734 2000 WS6 Trans Am M6 Dyno : 420 RWHP 390 RWTQ WARM START All the engine mods and tunes were done by Simple Quick Racing in Benbrook,TX Mods: MS3 Cam, PRC Double Valve Springs, Chromly Pushrods, FAST 92/92 intake manifold, LS7 Clutch, Hurst Comp/Plus Shifter, Lid, K&N, OBX LT's, 3in ORX True Duals, KYB AGX shocks, BMR springs, BMR Adj. PHR, LCA Relos, STB, 315 NT555R, DeepDish C5Z06s.
Regular Car Reviews: 2001 Pontiac Trans Am Firebird WS6
NNGH! HRRGH! *Snorts* UGGS. hut hut HIKE! Thank you to: Pypes Exgaust 2705 Clemens Road, Building 103B Hatfield, PA 19440 http://pypesExhaust.com/
2000 Pontiac Trans Am MS4 cam idle open cutout
2000 Silver Pontiac Trans Am ws6 6 speed: MS4 110lsa Cam only Ported Fast 90/90 Longtubes / Custom ORY / E cutout/ Flowmaster catback Monster clutch Moser 9" Detroit locker with 4.30 gears UMI Suspension Qa1 coil overs LPE 2-step Weld RT-S wheels


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Changing Power Steering Pump
How easy is it to buy a mopar power steering pump, and change it myself?
I took my Jeep down to the Jeep Service Center and as it happens the car didn't make the chewbacca sound, "thanks god"
So anyway, the service center couldn't fix it because the sound could not be replicated, they checked the fluid which was fine, but now my car needs to be taken in for x amount of days so it can "diagnosed" which will cost £72 per hour, and there is no certainty that it will make the sound during that time, which means i could be £200 poorer, and a without a car.
So I was hoping that I could do this myself, is it possible? can someone with relative little car mechanical experience change the pump? Are there any how to videos?
(should add its a 3.0 CRD UK SPEC)
Re: Changing Power Steering Pump
bump, I need to do mine also
Re: Changing Power Steering Pump
its not hard if you get the pump with the pulley on it. Its really easy to get to... i ordered mine from the dealership which came with the pulley, i think it was 125, not certain though. I think it was pretty easy to change. If you dont get the pulley already installed then you'll need a special tool to take off the old pulley, it may save a few bucks, but way more of a PITA.
Re: Changing Power Steering Pump
Comon guys help is needed, anyone fancy a trip to London UK?
Re: Changing Power Steering Pump
i just changed mine last month. my jeep has 40k miles on it. i have the 5.7L hemi and it uses a different pump than the 3.7L or 4.7L. it cost me around $140 at the dealer and it had the pulley on it. i tried advance auto parts, autozone, o'reillys, and napa and nobody could get me one for the 5.7L. the dealer was my only option. you have to disconnect the reservoir line, take the serpentinte belt off and take out the bolts. the pump is right on top and right in front. easy job. maybe 15 minutes. don't take the serpentine belt off of everything else. make sure you use the correct fluid. i ended up buying the fluid from the dealer. it takes just over 1 quart to fill it. $16/quart at the dealer.
Re: Changing Power Steering Pump
Re: Changing Power Steering Pump
Re: Changing Power Steering Pump
Whats MB?
OK figured it out M-Benz!
You had any issues with your power steering? 28k and a pump issue already! so ****ing annoyed man.
Re: Changing Power Steering Pump
May also be worth checking out
Re: Changing Power Steering Pump
Telly is crap so I am surfing
Found this which could be very relevant
And this lot are just south of the river (Thames)
Re: Changing Power Steering Pump
I'm on my fourth! the first time i bought one used and when i got under the jeep, i said.. HELL NO! took it in and saved myself the cursing and bloody knuckles.
Re: Changing Power Steering Pump
I am surprised at your problems, am on my second Grand Cherokee, the 1st one was a 55 plate and had done 88,000 miles when I got rid having had nothing wear or break. My second one (56 plate) I have had for 6 months and added 14000 miles (now 46000) and again, no problems
And Yes Mercedes Benz, I think the motor will have been shipped with all ancilleries including PAS pump and I would be very surprised if it has failed at the low mileage you mention
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Hotel search
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These prices aren't available to everyone.
Trending now in Miami
- Most bookedFontainebleau Miami Beach
1,137 people looked at this hotel in the last hour
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"My experience was fabulous the only point is that everything is very expensive and this hotel don'T give nothing free "
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"great service, great location and great rooms make this hotel a good choice"
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"Great location for anyone traveling to or from the airport, especially with the free airport shuttle. The hotel staff was incredibly nice and helpful. The room was very nice too except for the bathroom door (seemed warped and struggled to close all the way) and the toilet paper holder (awkward lo..."
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"Our family of 4 had an amazing stay at this resort. There were a lot of renovations going on while we were there, but we knew about this from reading recent reviews. Upon checking in we were told we could have a room immediately, 2:45pm, but it would be a balcony room where the balcony would be..."
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"The location is amazing, right on Lauderdale beach! Staff was great. Bed was fab. Lots of restaurants within 1/2 mile walking. Beachfront shopping scattered along the road that runs adjacent to the beach. Shopping mall less than a mile away. Pool is wonderful, but the beach is WOW! Your st..."
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"Our stay was very good. Our room had a confortble size, Great reception service, friendly staff. We arrived early and our room was ready for us. Nice surprise! The location is perfect! Negatives:The bathroom is small, doors are too loud."
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"We are from Michigan and often visit Miami.. this by far was the best hotel yet we have stayed in !!!"
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"The location is 100% great! The service and room size is also very good. Only one thing is the hotel is old it need new decoration done asap.But over all ,it is still 9 /10."
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"Very large hotel, nice rooms. We had 5 rooms and only wish we would have been closer together. We were spread all over the hotel."
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216 people looked at this hotel in the last hour
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"A flight cancellation forced us to stay overnight. Only used the room and restaurant. Shuttle pick-up was good, check in was easy. Check out was easy. Shuttle doesn't run early enough in the morning for flights before ~7:30 am (ours was at 5:20 am) so you may need a cab. Restaurant was expensi..."
A Traveller, Jan 2017, US
Map of Miami hotels
- Port of Miami
- Ocean Drive
- Lincoln Road Mall
- American Airlines Arena
- Miami Seaquarium
- Marlins Park
- Miami Beach Convention Center
- Dolphin Mall
- Bayfront Park
- University of Miami
- Seminole Hard Rock Casino Hollywood
- Las Olas Beach
- Fort Lauderdale Beach Park
- Bayside Marketplace
- Little Havana
- Aventura Mall
- Las Olas Riverfront
- Greater Fort Lauderdale-Broward County Convention Center
- Gulfstream Park Racing and Casino
- Dadeland Mall
What to do in Miami
Miami overviewMiami is a budget-friendly place distinct for its beaches and sports, and known for its port and shops. You're sure to find the coffee and bar options to your liking. Take in some local culture at popular places like Vizcaya Museum and Gardens and Patricia And Phillip Frost Museum Of Science. Popular attractions like Port of Miami and University of Miami are sure to leave an impression. A family- and business-friendly area, Miami also has something for everyone.
Where to stay in MiamiWith a wide assortment of lodging choices to choose from, Miami has options to suit everyone's style. There are 688 hotels in the Miami area and you can shop as many as 308 deals for rooms on Hotels.com, some with discounts of up to 30%.
- • 89 2-star hotels with an average price of $54 per night
- • 299 3-star hotels with an average price of $78 per night
- • 230 4-star hotels with an average price of $99 per night
- • 44 5-star hotels with an average price of $189 per night
Here are the top hotels based on 232489 user reviews of Miami hotels:
- • Four Seasons Residences (Downtown Miami)
- • Hotel Beaux Arts Miami (Downtown Miami)
- • JW Marriott Marquis Miami (Downtown Miami)
- • Mandarin Oriental Miami (Downtown Miami)
- • The Vagabond Hotel (MiMo)
How to get to MiamiFly in to Miami, FL (MPB-Public Seaplane Base), 1.1 mi (1.8 km) from downtown Miami. Miami, FL (MIA-Miami Intl.) is the next closest major airport, 5.7 mi (9.2 km) away.
Train stations include:
- • Miami Airport Station
- • Miami Station
- • Knight Center Metromover Station
- • Riverwalk Metromover Station
- • Bayfront Park Metromover Station
What to see around MiamiFun activities are on hand like exploring the port and sporting events, along with attractions such as:
- • Island Queen Cruises
- • Port of Miami
- • Crandon Marina
- • Miami Beach Marina
- • Haulover Park Marina
- • Arcade Odyssey
- • Zoo Miami
- • Zoological Wildlife Foundation
- • Monkey Jungle
- • Pinecrest Gardens
- • Lummus Park Beach
- • Surfside Beach
- • Dog Beach
- • Kendall Breeze Shopping Center
- • Pine Lake Shopping Center
- • Dolphin Mall
- • Miami International Mall
- • Dadeland Mall
- • University of Miami
- • Vizcaya Museum and Gardens
- • Frost Art Museum
- • Miracle Mile
- • Patricia And Phillip Frost Museum Of Science
When to visit MiamiCurious about when's the best time to visit? Here are the seasonal norms to help with your planning:
Seasonal temperature averages
- • January-March: 82°F day, 60°F night
- • April-June: 90°F day, 66°F night
- • July-September: 91°F day, 76°F night
- • October-December: 88°F day, 60°F night
- • January-March: 6.9 inches
- • April-June: 18.2 inches
- • July-September: 25.2 inches
- • October-December: 11.7 inches
Miami travel guides
Shopping in Miami - Style, Substance, and Smokes
Miami's reputation as the playground of the rich and famous makes it the ideal spot for upscale desi...
Miami - A Tour of the Best Neighborhood Attractions
It's such a cliché to say that a destination has "something for everyone," but it's a pretty forthri...
Miami Nightlife and Entertainment - Drink, Dance, and Live La Vida
You'd be hard-pressed to find a city with nightlife as dazzling and diverse as Miami's. A multitude ...


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Hi Guest, welcome to the TES Community!
Connect with like-minded professionals and have your say on the issues that matter to you.
Don't forget to look at the how to guide in the welcome lounge and help forum.
ICT jobs - where have they gone?
Discussion in 'Computing and ICT' started by mossonbrick, Feb 4, 2011.


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Accessibility tools
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On 30 April 2014, on the occasion of the 10th anniversary of the 2004 enlargement, Štefan Füle, Member of the EC in charge of Enlargement and European Neighbourhood Policy, made a press statement.
On 1 May 2004, the EU enlarged from 15 to 25 Member States (and with two subsequent enlargements to 28). It brought stability and reunited Europe after years of artificial division during the cold war; it made the EU the world's biggest single market and increased trade between Member States, thus contributing to economic growth and strengthening further Europe's weight in global affairs.


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Swans' 'big task' at Chelsea - Clement
Swansea City manager Paul Clement relishes Saturday's trip to former club Chelsea in the Premier League.BBC Sport » 1h
Swansea City manager Paul Clement relishes Saturday's trip to former club Chelsea in the Premier League.BBC Sport » 1h
We asked the Soccer Saturday pundits to predict who will face relegation from the Premier League this season.SkySports.com » 2h
Ahead of Sunday's EFL Cup final live on Sky Sports , we recall one of the most memorable meetings between Manchester United and Southampton - when Sir Alex Ferguson's side famously changed kits halfway through a 3-1 defeat at The Dell…SkySports.com » 2h
Sutton's players will "go down in history" despite missing out on a place in the FA Cup quarter-finals, says manager Paul Doswell.BBC Sport » 8h
• Arsenal manager pays tribute to 'astonishing' Sutton United • Wenger says bottle was thrown in his direction during 2-0 win Arsène Wenger departed here unscathed but also astonished by the quality that Sutton United showed in pushing Arsenal during their FA Cup tie in suburban Surrey. Although…Guardian » 8h
The latest transfer rumours making the back pages of Tuesday's papers, including a report linking Arsenal with a move for Lorenzo Insigne.SkySports.com » 8h
Club asked to explain actions of fans after homophobic banner displayed Unrepentant Red and Black Bloc label FFA 'dictatorial' In the face of widespread condemnation and with another show-cause notice issued to their club, Western Sydney Wanderers fan group, the Red and Black Bloc, are refusing to…Guardian » 8h
Manager has time to relax as Arsenal's much-changed team avoid major upset against non-league Sutton United to reach FA Cup quarter-finals For all the talk of Cup magic this was in the end an orderly out-ground experience for Arsenal, a 2-0 fifth-round victory that felt by the end like a gently…Guardian » 9h
Ore team results show all results by season and for international teams, the last 50 matches.
Click on any result to get the details of the match including stats at the time the game was played!
|UEFA Europa League 2011-2012
|AEK Larnaca
|AEK Larnaca


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Edit your search:(X) Kansas
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Residential Security Consultant
Protection 1 - Wichita, KSIf your experience is in presenting products and services to consumers, especially homeowners this role could be the right choice for you! You bring the drive and ambition for success and Protection 1 supplies industry leading technology, great products, sales support and training from Day 1! ...
Posted: 2012-05-01 | Industry: Security | Base Salary: 100% commission
Residential Sales Consultant
Protection 1 - Wichita, KSAs an outside sales consultant, grow the customer base by selling security systems to homeowners; cold calling and networking to find new business. To perform this job successfully the Residential Security Consultant may be expected to perform some or all of the duties listed and perform other ...
Posted: 2011-09-12 | Industry: Security | Base Salary: 100% commission
Residential Security Consultant
Protection 1 - Wichita, KSTraining: Protection 1 University provides you with paid training focused on helping you learn about the security industry and products. After training, we continue to communicate to keep you in the loop on product and process updates. We make the most of technology not just in our product lin ...
Posted: 2012-05-01 | Industry: Security | Base Salary: 100% commission
Commercial Sales Consultant
Protection 1 - Wichita, KSResponsible for the design and sale of Access Control, CCTV, Burglar, Intercom and Fire Systems to commercial businesses. Develops new business prospects and interacts with existing customers to increase sales of security systems and/or services. To perform this job successfully, the Commerci ...
Posted: 2017-02-12 | Industry: Security | Base Salary: Yes (amount not posted)
Aftermarket / Customer Service Sales Representative
Crown Equipment Corporation - Wichita, KSCOMPANY INFORMATION: Privately owned, Crown Equipment Corporation, designs, manufactures, distributes and supports material handling products that provide customers with superior value. Crown has a network of factory direct sales and service dealers (referred to as branches) doing business as Cr ...
Posted: 2017-01-27 | Industry: Industrial | Base Salary: Yes (amount not posted)
Experienced Sales Professional
Harvard Risk Management Corporation - Wichita, KSHRMC is a 20+ year old company in search of a sales consultant who is comfortable speaking in front of groups and looking to make a difference by educating consumers Qualified applicants should possess: * Self Management skills * Great organizational skills * Professional Acumen Accepted candi ...
Posted: 2017-01-19 | Industry: Professional Services | Base Salary: 100% commission
Inside Sales Supervisor
Protection 1 - Wichita, KSSUMMARY: Manages the daily activities of the Telesales staff in the attainment of departmental goals while ensuring the highest possible level of customer service. Provides leadership and coaching for Telesales representatives to assure that all employees succeed in meeting individual goals for p ...
Posted: 2017-02-11 | Industry: Professional Services | Base Salary: At least $20,000
Residential and Small Business Sales Rep
Protection 1 - Wichita, KSSUMMARY: As an outside sales consultant, grow the customer base by selling security systems to homeowners and small businesses; involves prospecting, cold calling and networking to find new business. ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. To perform this job successfully t ...
Posted: 2016-05-06 | Industry: 100% Commission | Base Salary: 100% commission
Inside Sales Qualifier
Protection 1 - Wichita, KSSUMMARY: Protection 1 has grown to be the second largest security company in the United States because weve created a positive, competitive, customer service-oriented environment that promotes growth. If youre looking to join a world-class company that expects and rewards success, lets talk. The ...
Posted: 2017-01-29 | Industry: Professional Services | Base Salary: At least $20,000
Sales Team Leaders Needed
The Carter-Brinley Group - Wichita, KS$150K+ We Believe COMPENSATION is the Best MOTIVATION Sales Professionals can earn a 6-figure sales income while learning how to be a successful real estate investor and help others do the same. Learn to Fix & Flip, Buy & Hold, Wholesale and develop commercial projects. The Carter-Brinley Grou ...
Posted: 2017-02-19 | Industry: Work from Home | Base Salary: Yes (amount not posted)
Jobs 1-10 of 54 (Next 10)


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Here it says Mitt energized the base especially the indies which I posted on another thread. I also posted that 47% of the undecides said
Mitt won.
Rush warned everyone that the polls were already in before the debate and would be skewed for OBY even if Mitt won the debate.


text:
Regional North America United States Rhode Island Localities P Pawtucket Business and Economy
Subcategories 2
Related categories 2
Sites 17
Adamsdale Concrete
Ready mix concrete and concrete products for commercial and residential projects. Provides product list and contact information.
Aid Maintenance Company, Inc.
Offers cleaning, maintenance and janitorial building services. Find company and contact information.
Berger and Company Recycling Inc
Offering the collection and purchase of recyclable materials, plus sensitive document destruction. Includes materials handled and location map.
Bowerman Associates, Inc.
Builder and general contractor providing design/build construction and construction management of conventional and pre-engineered metal buildings for commercial, industrial, and institutional purposes. Find contact information and see past projects.
Courtesy Hyundai
Sales of new or used vehicles, parts, servicing and body shop. Includes inventory, hours and location map.
Crown Cut Packaging Inc.
Manufactures clear and colored boxes for product displays. Find product and contact information.
Diamond Dry Cleaners
Find a list of services provided and directions on how to get to this dry cleaner.
Glad Works Inc
A full-service design and marketing agency. Includes staff profiles, portfolio and client list.
Gold Event Planner
Specializing in event planning and destination management throughout southern New England. Includes testimonials and photo gallery.
Hasbro Inc.
Toy manufacturer, designer, and distributor with corporate headquarters in Pawtucket.
New England Linen Supply
Linens and uniform rental services. Featuring medical and culinary products.
Pawtucket Mill Supply Company
Offers a large stock of new and used textile machinery, including looms, warpers, and braiders.
Providence Yarn Company Inc
Wholesale distribution business supplying industrial yarns to manufacturers. Includes an overview of the product range.
SAGE Environmental, LLC
Provides environmental consulting services and construction site development assistance.
Tejax Engineering Co.
Manufacturer of digital and analog position indicators and handwheels. Provides product information.
Travel Advisors International
Agent for personal and business travel. Includes information on products and services, and contact information.
Van and Company
Supplies custom wooden cases and wood boxes for product displays and instruments. Offers a view of products and contact information.
Last update:February 1, 2017 at 12:24:03 UTC
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FYI: Keep on guard for FUD - fear, uncertainty, doubt
Catholic News Service
Here is a commentary from the June issue of
The Northern Cross
, the monthly newspaper of the Diocese of Duluth, Minn. It was written by the editor, Kyle Eller, who has a column called "Mere Catholicism."
DULUTH, Minn. — Most of us these days know a host of Internet or texting acronyms like "LOL" or "IMHO" ("laughing out loud" and "in my humble opinion" for the uninitiated).
One of my favorites is more obscure: "FUD." The term comes from the technology industry, where companies are sometimes accused of marketing or whisper campaigns designed to fill customers with "fear, uncertainty and doubt" -- FUD -- about a competitor.
The same concept is used elsewhere: in the marketplace, in politics and beyond.
What's key about FUD is that it isn't real. A legitimate warning about something truly dangerous or dubious is not FUD. FUD is not about helping anyone, it's about destroying trust and confidence in something else in hopes of advancing your own agenda.
I think it taps a real part of our psyche. It is astonishing how the smallest unsubstantiated doubt can change the way we look at something as trivial as an app on our computer ("Did someone say this has a virus?") or as important as a friendship. This seems to be true even when we think we know better.
Isn't it a common experience? We hear a rumor that a friend said or did something, and we have no real reason to believe it's true and good reason to believe it's false. We resolve not to believe it. (Justice demands no less!) And yet, when we see that friend again, we find ourselves fighting a doubt or a guardedness in ourselves, or tempted to be a detective observing closely to be sure all is as it ought to be.
A tiny dose of fear, uncertainty and doubt can have a completely disproportionate effect on us, breaking trust, tempting us to withhold a bit of our heart that we once gave freely.
We can see how effective FUD is by how widespread it is. Whatever else we may say about advertisers and political campaigners, they are savvy about what works, even if it contradicts what we all say. For instance, we all say we want elections that are based on the issues, not FUD in the form of negative personal attack ads and "gotcha" quotes. Yet which dominates our politics? FUD works.
Nowhere is FUD more abundant than in attacking the Catholic faith. I would argue that the devil is the origin of FUD. It is the very tactic he has been using since the Garden of Eden, where he tempted Eve to doubt God's truth, goodness and love. "Did God really tell you not to eat from any of the trees in the garden? You certainly will not die. God knows well that the moment you eat of it your eyes will be opened and you will be like gods who know what is good and what is bad."
Once you start to notice it, you see FUD is everywhere in attacks on the Catholic Church. Catholics hate science and reason? FUD. Catholics hate women? FUD. Catholics hate gay people? FUD. Catholics want to impose theocracy on the world? FUD. Catholics worship Mary and hate the Bible? FUD. Catholics think you can work your way into heaven? FUD.
Even many instances where there are legitimate criticisms of things Catholics have done, for instance in the Crusades or the Spanish Inquisition, truth is mixed with FUD. This is a very effective tactic.
It is critical for us to recognize FUD and defeat it, both for ourselves, to guard against the wiles of the enemy, and for the sake of others whom we are attempting to reach with the new evangelization, our message of the love of Jesus Christ and his offer of communion with himself in the Catholic Church.
FUD is a deception, an illusion, an attempt to separate us from God, nothing more and nothing less.
No relationship depends more on our trust than our relationship with God, and no relationship is more important. Trust is really another way of describing faith: believing not just "in God" but believing God and what he says, what he proposes for our belief for our good. He asks our absolute trust and confidence.
Throughout the Bible we see examples of people who kept their faith despite being surrounded by fear, uncertainty and doubt. Think of the judges, the prophets, the Twelve Apostles after Pentecost who endured persecution, ridicule and death with unshakeable faith. I think of Daniel, holding fast to God even in the midst of exile and persecution, of Tobit doing the same. I think of Simeon, holding out hope in God's promise that he would see the Messiah even as he grew old. I think of the Blessed Mother, standing in faith at the foot of the cross.
We don't lack for witnesses in the 20 centuries of martyrs since, either.
God seems particularly to prize the trust of his chosen ones, especially when all hope appears lost, when it seems the world has forgotten him and that he is silent while his plans and promises come to nothing. It is through the cooperation and trust of these faithful ones that he acts, often dramatically, in his good time.
That is the trust to which we can aspire in these challenging times.
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How To Peel A Chestnut Step By Step
Since I have been buying fresh chestnuts by the bag full lately, I have been trying out every method I could find to peel them so I could use them in my recipes. One afternoon I actually took an hour or two and tried a few different methods I found on the internet to peel chestnuts to find the one that worked the best. Yes I know, perhaps my chestnut obsession is getting a little out of control, but just remember, my efforts are your gain! After trying the traditional method of cutting an X into the flat side of each chestnut and then boiling or roasting them, I did find a method that made peeling both the outer hard shell of the chestnut as well as the inner skin or pellicle much easier.
By cutting an X through the flat bottom of the chestnut where the inner skin is attached and toughest to remove I found both layers on the chestnut come off quite easily without much fuss. If you find the inner skin a bit sticky, simply drop that chestnut into the hot water for another minute or two. This method only requires boiling the chestnuts for 7 or 8 minutes, so once peeled they are not already half cooked. I have put a step by step guide together to help you understand exactly what I mean. Don't look at my nails please, after peeling too many chestnuts I am in dire need of an emergency manicure!
This is the area at the bottom of the chestnut that you need to cut.
Use a sharp knife and cut an X into the bottom of each chestnut while you get a pot of water boiling.
Warning – Do not cut the chestnut while holding it like this or you may cut yourself!
This is what the chestnut should look like after you have cut your X. Place the chestnuts in the boiling water for 7 to 8 minutes.
Remove just a few chestnuts at a time from the water and use your fingers to pull off first the outer shell, then the inner skin. If the skin is sticking, either use a sharp paring knife to help remove it, or simply drop it back in the water for a minute or two.
Pull off all of both the outer shell and inner skin.
This is a chestnut minus the outer shell with just the inner, fuzzy skin left on. I had the return this one to the hot water to remove the inner skin or pellicle.
Here are two perfectly cleaned chestnuts. Once cleaned, cut away any
darkened areas and discard any dark colored chestnuts.
Peeled and ready for using in my Roasted Brussel Sprout recipe!
Deborah Mele 2011
10 Responses to "How To Peel A Chestnut Step By Step"
Being of italian ethnicity, chestnuts were a staple in our home in the
Fall in New England. This Christmas my daughter and I will be in Italy. This is the first time I will be there at Christmastime, so I am looking forward to eating roasted chestnuts. Certainly they will be much fresher than what we get here in the states. By the time we get them, we are lucky with some, to even be able to peel them. I am anxious to try your method, and will shortly, as they are now appearing in our stores.. Buon Natale….
My family loves roasted chestnuts. I have tried everything under the sun to get them to peel easily after roasting but have not succeeded. Any ideas would be welcomed.
Thank you. I shall give this a go.
I saw chestnuts at the markets (here in Queensland, Australia) and bought them on a whim. I had lovely images of roast chestnuts beside a log wood fire. Of course I don't have a fire place, it's subtropical here so I decided I would have to cook them somehow. I will try the x method.
I am surprised that you would cut the chestnuts against such a beautifully grained wood though. Is that some kind of cutting board or a piece of furniture?
I just bought and roasted my first chesnuts ever. The package had directions for roasting which was to cut an X then place in a 400 degree oven for 20 minutes. I followed the directions then allowed the nuts to cool before peeling. None of the nuts came out easily and I did not get a single whole one. As I was peeling/ breaking them I noticed that the very center meat had a very light purplish brown hue. Are the nuts spoiled? I tried a piece of one and it tasted ok. It was slightly soft and to me maybe a little mealy (like an apple before ithe spoils). I have never eaten chesnuts before and do not know what they should taste like or what the texture should be like. Do you think my chesnuts are safe to eat? Thank you for yòui advice.
I want whole chestnuts to use in a traditional stuffing, and their appearance is pretty important. So if the skin won't peel cleanly off the chestnut (and this is mostly the case with 90% of the ones I buy, no matter what method I follow: roasting, boiling, steaming, combination, etc.) I use a microplane to grate off the skin.
These "grated" chestnuts look more like baby potatoes, but they're whole and attractive enough, and it saves me some aggravation. Also, micro planing wastes no more meat than peeling, which ends up cutting into the chestnut meat, anyway. This works well with whole chestnuts, but not halves, which I find cannot withstand the stresses of grating.


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Machine should have been "wiped clean BEFORE being sold for the safety of the previous owners info. Because it wasn't, I'm going to assume it could be also be loaded w/ viruses/trojans etc.Common cause of trashing/selling a computer.
The problem w/ wiping clean is : CLEAN!! No Operating System at all!
If you do this you will need to buy a new retail version of a suitable
OS ($$$)for machine. Depending on model, age & specs (which you don't give) MAY
be able to take XP (min.512RAM? HD of 80 Gigs?) or not. Most UNlikely it is Vista compatible.
I assume you don't have original install disk w/ key (I you can get it, that would be very good). KEY may be on sticker on bottom or back of machine. Possible that it didn't have OS disk to begin with. Instead, back-up of original OS may be installed ON MACHINE in a separate partition (example Drive D or ?). If so, you can "Burn" a copy of it
(export) that to several CD-R's(4 or 6?)or fewer DVD R's(1 or 2?)if it has a burner.
This would be ideal!
Additionally, depending on age & OS, you maybe able to do a reformat to original factory conditions by using a process internal to original install. Often under " Start>All Programs>Accessories>System Tools" or in on-machine "help files" or go on line and look into "support" at manufacturer's site for info re this (or possibly it's in owners manual viewable/down loadable online ).
This would dump all except what the factory installed originally.
Great patience would be a great character trait to exhibit at this time..but it is doable. You really need to get all system specs you
can to safe guard.
As a first computer, I must applaud your courage at attempting this.
Would be VERY helpful IF you know a "Nerd" friend who has done similar to help you with this.
You may post back with more questions BUT we need ALL current system Info possible to be able to give more specific suggestions. Sandy
I just bought a used computer from a yard sale. It has a bunch of stuff on it. Stuff I don't need or would use. How do I delete the whole hard drive & start from scratch? Can I do that or do I just have to keep all of this stuff? Also if I do delete the whole thing, do I need a certain disk to put windows back or will it come back?
The computer is an emachines. I don't really know what tell about it. This is my first computer. I've used friends, but never one of my own. So I'm new to all this stuff.
Thanks for all your help.


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Why Infiniti believes this Q60 could be your fantasy car
Neiman Marcus and Infiniti are promising a very special head- turner of a vehicle as this year's fantasy car. Only 50 are being produced, in a stunning gold paint called "Solar Mica".
Neiman Marcus and Infiniti are promising a very special head- turner of a vehicle as this year's fantasy car. Only 50 are being produced, in a stunning gold paint called "Solar Mica".
Infiniti says the all-new 2017 QX30 was created to make a bold visual statement.
According to the luxury brand of Nissan, the remodeled Infiniti QX60 has the interior flexibility and roominess, safety, and advanced hospitality features buyers are looking for. Did they succeed?
The newly-redesigned 2016 Q60 is lower and wider than it was before. Its new design language is in line with the updates made for the Q50 sedan with strong lines along the hood and body.
Coming as 2017 models, the new Infiniti QX30 line of premium active crossovers will enter the United States and Canadian markets in three forms.
This is the most advanced engine that Infiniti has ever offered. It includes technology derived from the company's Formula One racing heritage and its advanced engineering department.
The 2016 Infiniti Q50 sedan looks a great deal like the 2015 model, but there is a big difference under the hood.
Nissan's Infiniti racing team is splitting off from long-time partner Red Bull Racing.
A recent test of the 3-row premium QX60 crossover from Infiniti left us impressed. Like all the competitors in the segment, the Infiniti makes us wonder why anyone needs a full-size SUV anymore.
The Infiniti Q30 is the latest from Nissan's luxury brand.
It's no secret that sales for the Infiniti brand have been slow.
The 2015 Infiniti Performance Engineering Academy has selected five global winners from engineering students around the world competing for a spot in this year's internship program for Infiniti pro
We're seeing rumors, once again, that Infiniti is working on a four-door sedan that utilizes the Nissan GT-R's underpinnings.
For the 2016 model year, Infiniti is making several changes to their line of luxury automobiles.
How about this for a weekend getaway: VIP treatment for two in Dubai, the chance to see a Formula One race up close and personal, and the opportunity to get into a real Formula One car and hit the
The Infiniti QX80 sport utility vehicle is not new to award winning, but this latest award from J.D. Power may be the most fitting yet.


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Distances given are in a straight line from the centre of Bath but travel routes may be longer.
1.4 Miles
Weston Park, Lower Weston, Bath BA1 4AS
1.0 Mile
16 Park Lane, Bath BA1 2XH
Stratton House, in Bath, has been thoroughly refurbished in order to support professional carers in the pursuit of an effective residential care service, that empowers occupants and supports independence. Situated within well-kept grounds, Stratton… more
Group / Provider:
MHA (Methodist Homes)
2.1 Miles
Mill Lane, Bathampton, Bath BA2 6TS
Bathampton Manor is a Grade II Listed Country Manor House set in a beautiful countryside position. The residential home is located close to the Kennet and Avon Canal, St Nicholas Church and local hostelries. The home provides round-the-clock care… more
1.1 Miles
Ivybank Park, Entry Hill, Bath BA2 5NF
Ivybank House is a friendly and welcoming care home located above the city of Bath. The home offers residential and respite care. The home has an extension with a modern wing, while bedrooms are set across two floors. The ground floor of the home… more
Group / Provider:
0.3 Miles
Hayesfield Park, Bath BA2 4QE
Greystones is a large detached house offering a warm and friendly atmosphere. The home is located close to Bear Flat local shopping centre and provides round-the-clock, personal care for older people. The single bedrooms are fully furnished, with… more
3.6 Miles
34 Avonpark, Winsley Hill, Limpley Stoke, Bath BA2 7FF
Hillcrest House is one of several Bath care facilities owned by Retirement Villages and dedicated to providing effective care packages for the needs of elderly residents, in comfortable and pleasant surroundings. The accommodation has a thirty-four… more
1.1 Miles
Oakwood Gardens, Bathwick Hill, Bath BA2 6EJ
Smallcombe House was opened in March 1992 and is owned and run by The Salvation Army. Admission is open to anyone irrespective of personal belief but the ethos of the home is Christian. Not all staff are practising Christians but Smallcombe House is… more
Group / Provider:
The Salvation Army
Alexander Heights Residential Home
3.6 Miles
28 Avonpark, Winsley Hill, Limpley Stoke, Bath BA2 7FF
Alexander Heights Residential Home is a twenty-eight facility manned by an experienced care team who are fully dedicated to the needs of each individual service user. This comfortable and spacious accommodation is an excellent choice for people to… more
Bath Community Resource Centre, Cleeve Green, Twerton, Bath BA2 1RS
1.7 Miles
Oriel Gardens, Swainswick, Bath BA1 7AS
1.8 Miles
Bradford-on-Avon BA15 1SU
5.2 Miles
Action on Hearing Loss (RNID) Barron Winnicott
Poolmead Centre, Watery Lane, Bath BA2 1RN
1.6 Miles
10 Tanners Walk, off Newton Road, Twerton, Bath BA2 1RG
2.0 Miles
46 Dartmouth Avenue, Bath BA2 1AT
1.0 Mile
Innox Lane, Upper Swainswick, Bath BA1 8DD
2.3 Miles
Bath BA2 3HP
0.4 Miles
8 Chandag Road, Keynsham, Bristol BS31 1NR
5.9 Miles
Action on Hearing Loss (RNID) Newbridge Hill
51 Newbridge Hill, Bath BA1 3PR
1.3 Miles
21 Entry Hill Park, Bath BA2 5ND
1.2 Miles
Bradford-on-Avon BA15 1SU
5.2 Miles
40 Gladstone Road, Combe Down, Bath BA2 5HL
1.6 Miles
Newbridge Towers Residential Care Home
169 New Bridge Hill, Newbridge, Weston, Bath BA1 3PX
1.6 Miles
Action on Hearing Loss (RNID) Watery Lane Cottage
Poolemead Centre, Watery Lane, Twerton, Bath BA2 1RN
1.6 Miles
42-44 Barry Road, Oldland Common, Bristol BS30 6QY
6.2 Miles
Action on Hearing Loss (RNID) Dominion Road
29-30 Dominion Road, Twerton, Bath BA2 1DW
1.5 Miles
Action on Hearing Loss (RNID) Ashley Phoenix
Poolemead Centre, Watery Lane, Bath BA2 1RN
1.6 Miles
Englishcombe House Residential Home
Englishcombe House, 33 Englishcombe Lane, Bath BA2 2EE
1.0 Mile
Action on Hearing Loss (RNID) Gallaudet
Poolmead Centre, Watery Lane, Bath BA2 1RN
1.6 Miles


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Marinated Broccoli
|3 Bunch (300 gm)
|Cider vinegar
|1 1⁄2 Cup (24 tbs)
|Fresh dill/1 tablespoon dried dillweed
|2 Tablespoon
|Granulated sugar
|1 Tablespoon
|Corn oil/Safflower oil
|1 Tablespoon
|1 Teaspoon
|1 Teaspoon
|1 Clove (5 gm), finely chopped
Slice broccoli into long pieces.
Into a large bowl place broccoli.
In a small bowl combine vinegar, dill, sugar, oil, salt, pepper and garlic; mix well.
Pour over broccoli.
Refrigerate for 24 hours.
Baste broccoli with marinade; drain.
Into a serving bowl place broccoli.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 393 Calories from Fat 147
% Daily Value*
Total Fat 17 g25.6%
Saturated Fat 1.3 g6.7%
Trans Fat 0.1 g
Cholesterol 0 mg
Sodium 2117.9 mg88.2%
Total Carbohydrates 43 g14.2%
Dietary Fiber 8.7 g34.8%
Sugars 21.7 g
Protein 10 g20%
Vitamin A 83.7% Vitamin C 491.1%
Calcium 23.9% Iron 27.7%
*Based on a 2000 Calorie diet


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Dear World: Beliefs have consequences as the old conservative once said. It, however, is not just a conservative sentiment.
I made an observation earlier today: It appears that Social Democracy in France, the UK, and Germany is in the decline because greens, Euro-liberals, and the Center Right are in dominance.
Need to learn more about Jainism to finish a chapter.
` I am designing my brother's tattoo. This is kind of fun.


text:
created by Amuzenet and published by Amuzenet
Infinite runner with a twist - you play as a ninja being pursued by a mysterious man in a suit.
Oh, you're one of those awesome people who already has an account on Player.me? Cool, you can just log in below!
Discover a lot in Player.me and start growing your gaming network.
By signing up, you are agreeing to our terms and you have read our privacy policy.
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text:
Logan Balow's "Chipotle Cordon Bleu" and Daniel Olson's "Dangerous Dan's Taco Burger" recipes are putting Wisconsin on the gourmet burger map for kids.
The recipes from the 12-year-old cooks are featured in the 3rd annual "Red Robin Kids' Cook-Off" Cookbook available through the fall for free download at www.redrobin.coml. The online cookbook includes 48 other kid-invented gourmet burger recipes.
Balow, of Cudahy and Olson, of Lake Mills beat some 14,000 entries to be included in the cookbook. Kids ages six to 12 expressed their culinary creativity by submitting original gourmet burger recipes and 100-word statements on why their burgers deserved to be America's next gourmet burger. The cookbook recipes were chosen based on their inventive combination of ingredients and fun flavors, and the accompanying 100-word statement.
Balow's "Chipotle Cordon Bleu" is made with ground chicken, ground cumin, chili powder, an egg, pepper-jack cheese, chipotle raspberry sauce, paprika, breadcrumbs, Virginia ham, wheat buns and butter. Olson's "Dangerous Dan's Taco Burger" is made with ground beef, cheese taco seasoning, jalapeno peppers, shredded lettuce, tomatoes, a bun, Newman's Own All-Natural Bandito Chunky Salsa Pineapple, sour cream and nacho cheese.
Kids can enter gourmet burger recipes for Red Robin's 4th annual Kids' Cook-Off online and in all U.S. Red Robin® restaurants through Sept. 13. To download the "Red Robin Kids' Cook-Off" Cookbook and submit a recipe for the 4th annual Kids' Cook-Off, please visit www.redrobin.com
Read and share your thoughts on this story.


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These days everyone knows Dax Shepard as one of the stars of "Parenthood" and being half of Hollywood's most adorable couple, along with his wife Kristen Bell. What many might not remember is that he got his start in show business by working with Ashton Kutcher to prank celebrities on "Punk'd."
Shepard turns 38 on Thursday (Jan. 2) and to celebrate take a time warp back to the very first episode of "Punk'd" from 2003, which saw him pulling pranks Justin Timberlake and "Malcolm in the Middle" star Frankie Muniz. He actually makes Timberlake cry, which is pretty incredible.
Shepard has come a long way since appearing on the show, but you can never forget your roots. Happy birthday, Dax.


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Need You to Edit and Rearange WordPress Header and Put in Icons + Change Color
This project was successfully completed by rashidqureshi for $30 USD in a day.Get free quotes for a project like this
Project Budget$10 - $30 USD
Completed In1 day
Total Bids18
Project Description
My client's site is http://shreveportdentist.com. It's a wordpress site.
Here's what I need:
1. change the header to black just like http://patcrawforddds.com. Actually the client likes [url removed, login to view] so much that he wants pretty much the same thing - so keep that in mind as you read this. If you could scale the colors that would be great - notice how it's not a hard black, but it changes color slightly.
2. Move the menu tabs below the phone number and move the phone number up and to the right a little - just like patcrawforddds.com.
3. Move the logo to the left slightly and move the menu tabs to the right slightly so that the logo and tabs don't overlap
4. Make the menu tab and phone numbers have white font to stick out of the black background.
5. Make the "Request Appointment" Menu tab a different color to stick out. Perhaps.
6. Put the Facebook icon + like count to the right of the phone number. His Facebook page is [url removed, login to view] - make the icon size just like this: [url removed, login to view]
7. Add these 2 icons to the left of the phone number (see attachments). for a visual, these icons should go right where the "get in touch now" text is on patcrawforddds.com. And to the right of the phone number, there's a little space - that's where the FB icon would go so it will look perfect.
Keep the phone number as text though so people can click 2 call on mobile.
I would like to get this done for $30 or less - since it should only take 3 hours or less.
I will give you all the logins you need once I hire you.
Post the word "Mastermind" when you respond so I know you read this.
Looking to make some money?
- Set your budget and the timeframe
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- Get paid for your work
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Nice poster, your version has got to be better than the one starring Ryan Phillipe and Benecio Del.
As far as Rueben Patterson he did that in his own home, and possibly under the influence which "is/was an out" in some states for deviant behavior. To compare to Arenas I think he would have to have forced himself on a Wizard's trainer's assistant staying late after practice.
Stephen Jackson was more embarrasing, because of the time of day and location and was with three other pacers. Chances he had his gun for protection because he was going some where seedy.
Gilbert's actions were premeditated, scary, wrong kind of inciteful, in the work place putting others in danger within the organization.
I love a comeback story. Just not here.


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Cheap Avenue Q tickets in NY
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Bromoacetonitrile was used in the synthesis of 1-cyanomethyl-1,1-dimethylhydrazinium bromide. It is used as an alkalyting agent for the nitrogen phosphorus detector.
Carles Miró Sabaté; Henri Delalu; Erwann Jeanneau. Synthesis, characterization, and energetic properties of salts of the 1-cyanomethyl-1,1-dimethylhydrazinium cation. Chemistry An Asian Journal. 2012, 7 (5), 1085-1095 .
Ho-Sang. Shin; Seungki. Kim; Seung-Woon. Myung; Jong-Sei. Park. Iodoacetonitrile and Bromoacetonitrile as Alkylating Reagents for the Nitrogen-Phosphorus Detector. Anal. Chem. 1995, 67 (11), 1853-1859.
Phenols can be protected (K2CO3, acetone) as their cyanomethyl ethers which can be cleaved by hydrogenation of the nitrile: Tetrahedron Lett., 34, 7567 (1993).
The Reformatsky-type reaction with cyclohexanone is more successful in the presence of a Zn/Ag couple than with the conventional Zn-Cu couple: Synth. Commun., 19, 2355 (1989). Good yields of ß-hydroxy nitriles have also been achieved from aldehydes and ketones using Zn and TMS chloride: Tetrahedron Lett., 31, 2205 (1990). The condensation with aldehydes can also be mediated by active Ni: Tetrahedron Lett., 26, 155 (1985). The reaction with aldehydes in the presence of Zn and tri-n-butylphosphine gives ɑß-unsaturated nitriles directly: Synth. Commun., 20, 3277 (1990).
Gefahrenhinweise (EU): H301-H311-H331-H315-H319-H335-H227
Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.
Sicherheitshinweise: P210-P261-P280-P301+P310-P305+P351+P338-P361-P304+P340-P311-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


text:
How To Make Tie Dye Shirts, Decor & More: 18 Tie Dye Patterns
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Latest Comments
"The Hushabye Shell Afghan is a beautiful blanket that would be a great shower gift. The pattern is an easy shell stitch and the colts are great for a boy or girl. I am sure that it will keep baby nice and warm. It is made with a nice four ply yarn and should work up fast. This one to save for a later date."
"The wavy rainbow baby blanket is one of the cutest that I have seen. The colors are so bright that a baby will enjoy looking at it. The blanket could also be worked up in other colors that would be great for that special little one. this is not for a beginner, so if this is your first try at crocheting you may not want to try it. Looking forward to working on this."
"The Springtime Lace Afghan Pattern is so cute. It will make a great baby blanket for that special baby. This could be made in many different colors that will really be pretty. The pattern reads really easy and a beginner could do this.I am looking forward to to this project in the very near future."
"he Cape Cod Afghan is really a cute pattern. It would be a great one for beginners. The pattern only calls for two skeins of yarn. The pattern reads really easy. This could also be used as a baby blanket and would look great in one of those baby colors. This is one pattern that I will definitely save for a later project down the road."
Beginner's Guide to Acrylic Painting
By: Maria Nerius
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There are so many wonderful projects you can make as an acrylic painter and with a little practice you can master decorative strokes that will take your painting to new levels in no time at all. Acrylic paint is the easiest type of paint to do as its quick drying, but still allows you to easily shade, highlight, and basecoat. Shading is adding shadow to an element while highlighting allows you to add light; basecoating is simply the painting done to fill in areas on a project.
There are many brands of acrylic paint on the market so you may want to experiment with several brands until you find the one you like best. No matter what company makes your acrylic paint, colors will blend and work well together. The most basic colors of paint you'll need are white, black, burnt umber (the most often used shading color), yellow, red, and blue. You can mix just about any color with these basics and add colors you need for projects as you go along.
Painting projects will usually include a list of paint colors used, brushes used, and a pattern. You can use transfer paper to copy the pattern onto your surface or free draw lightly with pencil. Acrylic paint bonds well with most porous surfaces. If you are trying to paint on a non-porous surface you'll need to prep the surface using by a light sanding called "giving the surface teeth) or ability to bond with the surface. There are also special acrylic paints for painting on glass or metal. You'll also find outdoor quality acrylic paint for any surfaces you want to place outside.
There are two kinds of brushes used in acrylic painting; rounds and flats. The sizes vary and are denoted by numbers like 00, 6, or 24. The larger the brush number, the larger the brush head. Rounds are used for decorative work including lettering, line detail, and flourishes. Flats are used for basecoating, shading, and highlighting. You can find paint brush tips here. Another tool you'll find helpful is called a stylus, which is a tool with a metal head used for accenting and dotting.
As mentioned before, you can paint on just about any surface; some surfaces require little or no prep while others can require some sanding or medium to the surface. Click here to see how to prep for painting on metal. A medium is any kind of liquid or solution used in painting like gesso, fabric, candle, or antiquing mediums. Sealers and finishes are considered mediums too. Sealers and finished are used to protect the finished projects. You can brush on a sealer or spray on a finish. Sealers and finishes come clear or matte. Clear has a shine to it while matte is a protective coat that is dull without shine.
Here are some great beginner projects for acrylic painting:
Be Merry Frame from DecoArt: Just in time for the holidays this frame is great for a home decoration or to make as a gift. Creating this painted, holiday photo frame is child's play with a few paints.
Home For The Birds by DecoArt: Birdhouses are always a popular deco item inside or outside the home. This warm colored cottage for the birdies is easy, but fun.
Jolly Roger Treasure Box: Ahoy all ye pirates! This delightful box is fun to make and a perfect party favor or gift. Combine painting and transfers.
Butterfly Tray by Chris Thornton-Deason for Delta Creative: Using the lovely colors of spring and bold colors of summer, this butterfly tray is a quick and easy painting project. Add it to your spring kitchen decor or give it as a gift to a friend to celebrate the season.
Family Sign: Challenge yourself with this lovely hand painted "family" sign. Give it as a gift or use this as great way to keep track of keys and coats.
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Our Best Practices pre-processing documentation assumes a simple experimental design in which you have one set of input sequence files (forward/reverse or interleaved FASTQ, or unmapped uBAM) per sample, and you run each step of the pre-processing workflow separately for each sample, resulting in one BAM file per sample at the end of this phase.
However, if you are generating multiple libraries for each sample, and/or multiplexing samples within and/or across sequencing lanes, the data must be de-multiplexed before pre-processing, typically resulting in multiple sets of FASTQ files per sample all of which should have distinct read group IDs (RGID).
At that point there are several different valid strategies for implementing the pre-processing workflow. Here at the Broad Institute, we run the initial steps of the pre-processing workflow (mapping, sorting and marking duplicates) separately on each individual read group. Then we merge the data to produce a single BAM file for each sample (aggregation); this is done by re-running Mark Duplicates, this time on all read group BAM files for a sample at the same time. Then we run Indel Realignment and Base Recalibration on the aggregated per-sample BAM files. See the worked-out example below and this presentation for more details.
Note that there are many possible ways to achieve a similar result; here we present the way we think gives the best combination of efficiency and quality. This assumes that you are dealing with one or more samples, and each of them was sequenced on one or more lanes.
Let's say we have this example data (assuming interleaved FASTQs containing both forward and reverse reads) for two sample libraries, sampleA and sampleB, which were each sequenced on two lanes, lane1 and lane2:
These will each be identified as separate read groups A1, A2, B1 and B2. If we had multiple libraries per sample, we would further distinguish them (eg sampleA_lib1_lane1.fq leading to read group A11, sampleA_lib2_lane1.fq leading to read group A21 and so on).
Assuming that you received one FASTQ file per sample library, per lane of sequence data (which amounts to a read group), run each file through mapping and sorting. During the mapping step you assign read group information, which will be very important in the next steps so be sure to do it correctly. See the read groups dictionary entry for guidance.
The example data becomes:
At this point we mark duplicates in each read group BAM file (dedup), which allows us to estimate the complexity of the corresponding library of origin as a quality control step. This step is optional.
The example data becomes:
Technically this first run of marking duplicates is not necessary because we will run it again per-sample, and that per-sample marking would be enough to achieve the desired result. To reiterate, we only do this round of marking duplicates for QC purposes.
Once you have pre-processed each read group individually, you merge read groups belonging to the same sample into a single BAM file. You can do this as a standalone step, bur for the sake of efficiency we combine this with the per-readgroup duplicate marking step (it's simply a matter of passing the multiple inputs to MarkDuplicates in a single command).
The example data becomes:
To be clear, this is the round of marking duplicates that matters. It eliminates PCR duplicates (arising from library preparation) across all lanes in addition to optical duplicates (which are by definition only per-lane).
Then you run indel realignment (optional) and base recalibration (BQSR).
The example data becomes:
Realigning around indels per-sample leads to consistent alignments across all lanes within a sample. This step is only necessary if you will be using a locus-based variant caller like MuTect 1 or UnifiedGenotyper (for legacy reasons). If you will be using HaplotypeCaller or MuTect2, you do not need to perform indel realignment.
Base recalibration will be applied per-read group if you assigned appropriate read group information in your data. BaseRecalibrator distinguishes read groups by RGID, or RGPU if it is available (PU takes precedence over ID). This will identify separate read groups (distinguishing both lanes and libraries) as such even if they are in the same BAM file, and it will always process them separately -- as long as the read groups are identified correctly of course. There would be no sense in trying to recalibrate across lanes, since the purpose of this processing step is to compensate for the errors made by the machine during sequencing, and the lane is the base unit of the sequencing machine (assuming the equipment is Illumina HiSeq or similar technology).
People often ask also if it's worth the trouble to try realigning across all samples in a cohort. The answer is almost always no, unless you have very shallow coverage. The problem is that while it would be lovely to ensure consistent alignments around indels across all samples, the computational cost gets too ridiculous too fast. That being said, for contrastive calling projects -- such as cancer tumor/normals -- we do recommend realigning both the tumor and the normal together in general to avoid slight alignment differences between the two tissue types.
Geraldine Van der Auwera, PhD
Questions and comments up to August 2014 have been moved to an archival thread here:
Geraldine Van der Auwera, PhD
I have aligned paired end fast files using BOWTIE2, SAMTOOLS and BCFTOOLS.(SRR901606_1.fastq and SRR901606_2.fastq). Now I have eg606.sam, eg606.bam, eg606.sorted.bam, eg606.raw.bcf. Now which will be my starting point to improve the quality of my data. Is there any sample command line for GATK? " each pre-processing step individually: map & dedup -> realign -> recal." How can I do this?
I am trying to identify the best GATK pipeline to use with my multiplexed whole exome data.
In this topic, you say that it is better to run per-lane: map & dedup -> realign -> recal and then after merging lanes, a second pass of per-sample: dedup -> realign (but no 2nd pass of recal step, because "by definition there is no sense in trying to recalibrate across lanes").
Okay... it makes sense.
However, I found in the "1506" best practices slides (https://www.broadinstitute.org/gatk/events/slides/1506/GATKwr8-A-3-GATK_Best_Practices_and_Broad_pipelines.pdf):
Per-lane: map & dedup, merge lanes (aggregation), then per-sample: dedup (2nd pass) -> realign -> recal.
I feel confused now... I need your help please !
Hmm our docs may be slightly out of sync, apologies for the confusion. The two ways are essentially equivalent; in the past we recommended doing realignment twice but not anymore. We'll update this document to reflect that and be in sync with the slides.
Geraldine Van der Auwera, PhD
Edited the doc to reflect how pre-processing is implemented in production at Broad.
Geraldine Van der Auwera, PhD
Thank you for your quick response Geraldine !
Thank you for updating/editing this post. Thank you for emphasizing why Baserecalibration is being applied with in a lane, not across all lanes of a sample. Also, thanks for mentioning that PU takes precedence over ID in read groups for baserecalibration.
Previously you mentioned here , that it is better to re-align (RTC + IR) per lane. Doing per-lane clean up increases the probability of doing re-alignment in high depth regions, as the amount of data will be less when compared to the data in all-lanes-merged-sample bam file. If per-lane clean up is not done, then those high-depth regions will be skipped by GATK.
I see that the new guideline (Lane Level : Map + Sort +Dedup ; All-Lanes-Merged-Sample Level : Dedup + Realign + Recalibrate) is released/updated after the GATK v 3.5 release. Does that mean that, with previous GATK3.4 version it is better to Re-Align at lane level as it cannot re-align regions of high-depth in all-lanes-merged-sample bam file, where-as current GATK v3.5 has capability to re-align in high-depth regions in all-lanes-merged-sample bam file ?
My pipeline currently uses GATK v3.4, and it follows previous Best Practices guideline as follows (Lane Level : Map + Sort + Dedup + Realign + Recalibrate ; All-Lanes-Merged-Sample Level : Sort + Dedup + Realign).
I have 4 lanes of data per sample (from Nextseq500 instrument) and our exome fastq.gz files can be as large as ~20 million reads in both paired-end reads. Steps Realign + Recalibrate at lane level are time consuming, and skipping these 2 steps at lane level, and including the Baserecalibration step at merged sample level, as according to new recommendation, decreases my overall processing time.
If I switch to GATK v3.5, would indels will be properly realigned in high-depth regions, even though I skip lane-level-realignment ?
@mglclinical These recent edits don't reflect any significant change of operation in the tools, just a shift in pipeline implementation philosophy. While indel realignment used to be very important when we were calling variants with UnifiedGenotyper, the HaplotypeCaller's ability to perform its own realignment has reduced the importance of the pre-processing realignment. It is still performed because it can produce benefits for base recalibration, but now we're satisfied with a best-effort pass per-sample, as opposed to the more thorough pass that can be achieved per-lane.
So as long as you're calling variants with HaplotypeCaller, you can follow the new recommendations with either version without concern.
Geraldine Van der Auwera, PhD
@Geraldine_VdAuwera thanks for the quick clarification
Maybe I'm confused, but with the new shift in philosophy, there seems to be minimal value in aligning, sorting and de-duping the lane-specific fastq's now. Given the current philosophy, it does not appear that there would be much difference between any of the following approaches:
* GATK best practices: per-lane align, per-lane sort, per-lane de-dup, merged, re-sort, re-dedup, re-align, ....
* per-lane align, merge, sort, de-dup, re-align, ....
* concat fastq's, align, merge, sort, de-dup, re-align, ....
The article above states that the per-lane sorting reduces the complexity of the subsequent analysis, but unlike the previous suggested practice (which was aimed to reduce lane-specific artifacts and improve alignment accuracy), there seems to be little value in the additional computation).
Am I missing something? If not, would it make sense to modify the article to state that if you are using the UnifiedGenotyper, you should follow the old instructions; otherwise, if you are using the HaplotypeCaller, you can follow the updated instructions, or just follow one of the simpler pipelines that I just listed?
@Geraldine_VdAuwera said:
@mglclinical These recent edits don't reflect any significant change of operation in the tools, just a shift in pipeline implementation philosophy. While indel realignment used to be very important when we were calling variants with UnifiedGenotyper, the HaplotypeCaller's ability to perform its own realignment has reduced the importance of the pre-processing realignment. It is still performed because it can produce benefits for base recalibration, but now we're satisfied with a best-effort pass per-sample, as opposed to the more thorough pass that can be achieved per-lane.
So as long as you're calling variants with HaplotypeCaller, you can follow the new recommendations with either version without concern.
Hi @pwaltman, sorry for the late reply. You summarize our recommendations above as "per-lane align, per-lane sort, per-lane de-dup, merged, re-sort, re-dedup, re-align, ...." but to be clear in your terms it would be "per-lane align, per-lane sort, per-lane dedup, merge, (no re-sort), re-dedup (actually this step can be used to do the merge too), local realign (to be clear it's not a repeat of the original align), ...". This produces the same core advantages as the previous version but in a more compact and efficient workflow. You're correct that results should be largely equivalent to the two other workflows you propose if I'm reading them correctly (I assume you're not proposing to combine all the fastqs before genome-aligning, since you would lose the ability to distinguish read groups); the main difference is the double dedup, which we do for QC reasons (to get per-lane library complexity metrics).
Geraldine Van der Auwera, PhD
Thanks for this post, what shall I do for sample that have number of libraries and each library have number of lanes , should it be per-sample different library ending in one sample have number of bams file for each library?
Thanks for the detailed explanation. I wonder if it is okay to add RG information and consider different lanes after mark duplication for each sample please. Our samples are indeed multiplexed, but at the current stage I need to test multiple variant callers, I slightly prefer to just have one set of .dedup.bam for each sample. Thank you.
Sure, that's fine. All GATK tools that read BAM files can take multiple BAMs as input. As long as the RG info is correct the data will be handled appropriately internally.
Geraldine Van der Auwera, PhD
Hi Geraldine, thank you so much for the quick reply. Just to confirm, for each .dedup.bam file for each sample, if I can correctly label the @RG lines (one line per lane) at the start of the bam file, then this .dedup.bam should fit into GATK - is that correct please? Thanks a lot.
Yes, you are correct
Thanks for this post, it is very helpful. I am working with whole genome resequencing data with several sequencing lanes for each sample.
I have mapped the fastq files to the reference genome and now I have several bam files (one per lane) for each individual that I would like to process with GATK. I should have roughly 10x coverage per individual and will thus use ANGSD for SNP discovery.
If I understand properly I should get rid of the duplicates twice, before and after merging the bam files of one individual? And then run the indel-realignment and the base recalibration step on the merged bam file for an individual (the lane information should be kept by adding the read group info using picard tools before merging the files)?
I guess it is better to run the indel-realignment step as I'll use ANGSD for SNP calling and not an haplotype caller, right?
I am also wondering whether I should use GATK or samtools to remove the duplicates.
Thank you,
Hi @mariel,
I'm not familiar with ANGSD. What is your reason for using ANGSD rather than the GATK workflow?
Let me restrict my answer to the question of whether you should run MarkDuplicates twice. This post and thread already explains that running MarkDuplicates twice is only relevant if your sample was multiplexed and you care about duplicate metrics, i.e. a library complexity estimate that discounts optical duplicates.
This site has extensive documentation on GATK workflows that use GATK and Picard tools. Please let us know if you have questions pertaining to these tools.
Hi shlee,
Many thanks for your answer.
I was thinking using ANGSD for SNP discovery as I have low-coverage data (around 8-10x)
I would like to check if the read group information I'm going to include to the bam file with Picard tools are fine (I intend to use Mark Duplicates, base recalibration, indel realignment).
I have 1 library per sample, and all my 20 samples have been run on 6 sequencing lanes (all 20 samples are multiplexed on each lane).
Thus RGID would be: flow_cell/lane number
I am not sure whether the sample ID should be included here.
RGLB would be the library number, e.g. wHAXPI030603-63
RGPU would be flow_cell/lane number/sample_name
e.g. FCHVMHNCCXX_L0_IR23
RGSM would be the sample name, e.g IR23.
Do you think the above information are fine?
Thanks for the help,
Best wishes,
Hi Marie ( @mariel ),
Assuming each of your 120 files provides >100M bases in sequence, your RG fields designations look great. Given your data is low coverage, you should make sure each RGID group has enough reads for BaseRecalibrator to be effective. To quote from this document, you need "well in excess of 100M bases from a next-generation DNA sequencer per read group. 1B bases yields significantly better results."
For whoever else reads this thread, let's rehash the RG field designations.
flow_cell.lane_number and matching SM and LB fields. The resulting output single file has 6 RGIDs.
Make sure to run indel realignment before base recalibration. Also, in case you are unaware, we removed indel realignment recently from the Best Practice Workflows that use assembly-based variant calling, e.g. HaplotypeCaller & MuTect2. Workflows that use pileup-based callers, e.g. UnifiedGenotyper, still require indel realignment. So, depending on what type of caller ANGSD is, and the quality and type of data you have, keep this omission in mind.
I hope this answers your question.
Hi @shlee,
Thank you very much, this is very helpful!
I have around 6B bases per read group, so I should be able to run BaseRecalibrator.
Hi all,
I am reading all the articles and comments about pre-processing data from multiplexed sequencing.
They are very helpful and complete but I still have some doubts and I hope to not bother asking for help.
We have data sequenced with Illumina NextSeq, we loaded a single library that is a pool of 12 samples.
The flow cell has 4 lanes so at the end of de-multiplexing we have 4 paired fastq files per sample.
Reading the documentation I understand that the correct work flow is:
1) Per-lane alignment (I use BWA)
2) Per-lane sort (PICARD)
3) Per-lane AddOrReplaceReadGroup (PICARD)
4) MarkDuplicates (PICARD) specifying all the 4 bam files of single sample obtaining a single merged.dedup bam file
5) BaseQualityScoreRecalibrator (GATK) on merged.dedup file
6) HaplotypeCaller (GATK) on bam files
My doubt regards the point 3 specifically the values of RGID, RGLB, RGPU, RGSM that have to be specified in AddOrReplaceReadGroup tool.
As far as I understand I have to use a different RGID, RGSM and RGLB in the per-lane bams; the same RGPU for all the 4 bam files.
As RGID I am using samplename_lanenumber, the same value is assigned in RGSM field. The RGLB is the number of the lane while the RGPU is the flowcell number.
For example for the sampleA I will have:
1) Raw data
sampleA_L001_R1.fastq.gz sampleA_L001_R2.fastq.gz
sampleA_L002_R1.fastq.gz sampleA_L002_R2.fastq.gz
sampleA_L003_R1.fastq.gz sampleA_L003_R2.fastq.gz
sampleA_L004_R1.fastq.gz sampleA_L004_R2.fastq.gz
2) After alignment and AddOrReplaceReadGroup
sampleA_L001.bam with RGID=sampleA_L001 RGLB=L001 RGPU=HGH5YBGX2 RGSM=sampleA_L001
sampleA_L002.bam with RGID=sampleA_L002 RGLB=L002 RGPU=HGH5YBGX2 RGSM=sampleA_L002
sampleA_L003.bam with RGID=sampleA_L003 RGLB=L003 RGPU=HGH5YBGX2 RGSM=sampleA_L003
sampleA_L004.bam with RGID=sampleA_L004 RGLB=L004 RGPU=HGH5YBGX2 RGSM=sampleA_L004
3) After MarkDuplicates
4) After BQSR
Is that correct?
Do I have to redo a AddOrReplaceReadGroup after MarkDuplicates step?
Thank you so much for the help and the kind support.
Hi Stefania,
Have you looked at this article? I think that will clarify things.
hi @Sheila
Thanks for the suggestion, I read the article and I changed the RG of my bam files. The workflow used is:
1) Per-lane alignment (I use BWA)
2) Per-lane sort (PICARD)
3) Per-lane AddOrReplaceReadGroup (PICARD)
4) MarkDuplicates (PICARD) specifying all the 4 bam files of single sample obtaining a single merged.dedup bam file
5) BaseQualityScoreRecalibrator (GATK) on merged.dedup file
6) HaplotypeCaller (GATK) on bam files
And the RG assigned are:
sampleA_L001.bam with RGID=sampleA_L001 RGLB=sample_A RGPU=HGH5YBGX2 RGSM=sample_A
sampleA_L002.bam with RGID=sampleA_L002 RGLB=sample_A RGPU=HGH5YBGX2 RGSM=sample_A
sampleA_L003.bam with RGID=sampleA_L003 RGLB=sample_A RGPU=HGH5YBGX2 RGSM=sample_A
sampleA_L004.bam with RGID=sampleA_L004 RGLB=sample_A RGPU=HGH5YBGX2 RGSM=sample_A
It should be corrected.