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Recent guest reviews
We stayed for one night in one of the suites which had not been upgraded. It was very run down and quite dirty. Lots of building work going on so don't expect to lie in. However on a plus side the staff were amazing. We arrived very early and they let us use the leisure club to change Would I return only if a refurbished room was available
We could not get accommodation at the venue of the wedding we attended so we decided to stay at Star City. It was a good choice. Staff are excellent and our free upgrade to a wonderful view of the harbour on a high floor was very much appreciated. Clean, spacious rooms and a large comfy bed. Although our upgrade was to a 'smokers' suite (I'm a non smoker) it did not smell of cigarettes and was clean and airy. Close to everything including transport and the casino is open 24/7. Well worth the stay and we will be back.
Although the location of the Star is not my favourite (I like being on the other side of the harbour closer to chinatown), the hotel itself is beautiful, service friendly and pool is perfect for my kids. It is a bit of a hassle getting to the main entrance if you have minors because you have to walk the long around as opposed to cutting through the casino, but there are plenty of Pokestops around which made it more entertaining (we could collect from 3 stops from inside our room). The food court attached the casino is quite good as well.
Stayed at Astral Tower hotel as it is on Darling Harbour where we went to see concert at ICC Theatre. Light rail is downstairs. A nice walk to the ICC, Chinese Garden, Powerhouse Museum. The room was lovely with exceptionally comfortable really big bed and good sized bathroom. Being in the casino complex there are plenty of restaurants.
Great place for entertainment, good location you can walk within minutes to Darling Harbour & all great restaurants! I have stayed here at least 3-4 times a year for a weekend get away! The apartments are spacious and modern! The pool, spa and sauna are great ( seperate sauna for men & women) great city view!
We stayed for 2 nights in a standard room but it was nowhere near standard! From the reception to the room service the staff have been very kind and helpful. The room that we stayed was just fantastic. Compared to the other 5 star hotels in Sydney this one now is in my top 3. I also didnt expect it to be family friendly as when our kids joined us the next day they had so much fun in the pool. Breakfast was also better than most of the continental buffets you can find. Highly and strongly recommended!!!
I'm going to preface this by saying that I hate the casino and all it stands for. It is a cesspit of human misery and literally makes my skin crawl. And the entire Star Casino complex is geared around getting people into that casino. No thanks. I had what I think was a standard King room and was super impressed. I'm pretty hard to impress when it comes to hotel rooms but this room was awesome. The rooms have been freshly renovated and as such, show almost no sign or wear and tear. The bathroom was quite small but really lovely and obviously very clean. The bed was amazingly comfortable and the giant TV right in front of it was excellent. As for the dining, unfortunately, most of the dining options are geared more towards the casino visitors which isn't ideal. Due to Sydney's nanny-state drinking laws, the casino (which seems to be largely exempt from these laws, funny that) attracts people I generally would prefer not to be around. Does this make me a snob? Probably but I've been called worse. Trying to get some dinner was a pain in the backside. I tried Century and was basically grunted at by the rude guy on the front door so I left there and tried Harvest which had a queue of at least 50 people. Yeah, nah. Then I found Fat Noodle which unfortunately was in the middle of the casino floor and the food wasn't good enough to make up for this and also, the service was terrible. After my b-grade dinner at Fat Noodle I wanted to get a drink. The casino was grossing me out so I googled my options and decided to try my luck at the bar at Sokyo at The Darling (part of The Star but separate enough that my casino heebie jeebies went away). This was a good plan, the drinks at Sokyo were yummy and the service was friendly and impeccable. So in short, my rating of 4/5 is strictly for Astral Tower only, The Star complex as a whole is gross. And the hotel lost a point for the undies (not mine) I had to step over in the hallway outside my room.
Excellent service. The staff is very friendly and service minded. This is our first time in Australia. We had been travelling for 30 hours and were exhausted. We were so lucky to be able to excess our rooms early as we could make a very early check in. Thank you! We very much recommend this lovely hotel.
I stayed in a one bedroom suite at The Star. The room itself was new and the view was great. But when I went into the bedroom I noticed there was no separation of the bathtub and toilet from the bed. This gave a whole new meaning to open plan living. I've stayed in a lot of hotels and apartments in my travels but I've never seen anything so badly designed. Maybe if you're staying there by yourself it would be fine but two people may find it a bit too cosy. Also, the rate on this same room varies day-to-day and I was quoted $957 on one booking enquiry and a few days late the room was available for $483.
We stayed in the Star suite and it was magnificant. From the doorbell to the marble bathroom, this room was on another level. Breakfast was served in the morning on time, fresh and delicious with the staff also excellent.
Located in Darling Harbour within 2 miles (3 km) of Circular Quay, Astral Tower and Residences at The Star is within a few miles (5 km) of other popular sights such as Sydney Harbour Bridge. This 480-room, 5-star hotel has a full-service spa, a casino, and 20 restaurants. Located in central Pyrmont, the hotel is also near Sydney Opera House and University of Sydney.
Relish the Japanese cuisine at Sokyo, one of 20 onsite restaurants. Savor a meal from the privacy of your room with 24-hour room service, or get a pick-me-up at the 2 coffee shops/cafés. Start each morning with buffet breakfast, available for a fee from 7 AM to 10:30 AM.
All 480 rooms feature minibars, coffee makers, and safes. Guests can enjoy free WiFi and satellite TV. Beds sport premium bedding and bathrooms offer hair dryers. Phones, ironing boards, and desks are also standard.
Property features
Guests of Astral Tower and Residences at The Star have access to a full-service spa, a casino, and a nightclub. Valet parking is offered for AUD 45-55 per day. A multilingual staff is on hand to assist with dry cleaning/laundry and concierge services. Other amenities at this luxury hotel include an outdoor pool, a fitness center, and a spa tub.
Reviews from Trip Advisor
73% of guests recommend this hotelTotal of 1016 reviews


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Town Square
Full bellies all summer long
Original post made on Jun 15, 2013
Read the full story here Web Link posted Friday, June 14, 2013, 12:00 AM
Comments (2)
a resident of another community
on Jun 15, 2013 at 12:11 pm
I thing the MVWSD should not to have to do this but they do. Keep up the good works, keep those kids fed and happy. They well thank you in the end.
a resident of Cuesta Park
on Jun 17, 2013 at 12:49 pm
We are ONE community, and this is wonderful. I'm proud of our district for doing this.
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Happy Valentines – Let's Be Friends
By Laura Stec | 2 comments | 16,012 views
Engagement Rings: Myths and Options
By Chandrama Anderson | 1 comment | 1,104 views


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See all those languages up there? We translate Global Voices stories to make the world's citizen media available to everyone.
One Minute MBA uploaded a video explaining the global economic impact of Sino-Japanese war over the Diaoyu Islands (or Senkaku Islands) if it really happened.
The economic fall out from such a war between China and Japan would be horirific
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Iranian(Iran) Translation
This project received 5 bids from talented freelancers with an average bid price of $12 USD / hour.Get free quotes for a project like this
Project Budget$2 - $8 USD / hour
Total Bids5
Project Description
We need a person, who is a native Iranian(Iran) language speaker, for doing a translation from English. We have a website, that needs to be translated.
1. Native Iran citizen
2. Excellent knowledge of English language + Iranian language
3. Fast working
We will NOT accept any automated translations for our project - ONLY HUMAN TRANSLATIONS!
Please, attach some copies of previously done translations in the PMB, when bidding.
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The Best Application Launcher for Linux
Linux users have a few good application launchers to choose from, but if we had to pick, the feature-filled favorite GNOME Do would have to win the title of best.
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Feb 23, 2016, 08.29 PM | Source: PTI
With international oil prices slumping to 12-year low, it is being said that the government may, in the Budget next week, look at re-imposing 5 percent customs duty on crude oil imports to shore up its revenue by around Rs 18,000 crore.
Like this story, share it with millions of investors on M3
Dont reimpose customs duty on crude: Oil firms
With international oil prices slumping to 12-year low, it is being said that the government may, in the Budget next week, look at re-imposing 5 percent customs duty on crude oil imports to shore up its revenue by around Rs 18,000 crore.
"The refining margins have been under pressure for some time and profitability of refineries largely remains uncertain under the current uncertain global oil prices scenario," it said.
The government had cut customs duty on crude oil imports to zero from 5 percent in June 2011 when rates zoomed to over USD 100 per barrel. But with oil prices hovering at USD 30 a barrel now, the duty may be brought back.
PetroFed said customs duty on crude oil is not a pass through in sales price of product as per present pricing formulae and therefore shall lead to an increase in the input cost of the refineries.
"This will further dent the already eroding financials of refineries due to failing oil prices," it said. India imports about 78 per cent of its crude oil needs and remaining 22 per cent is supplied by domestic crude oil producers.
"On the domestic crude oil purchases too, refineries have to bear sales tax/VAT, ranging from 2 to 5 per cent, which cannot be passed on in the product prices as the VAT set-off credit is not permitted on the same. These levies are already being absorbed by the refining companies," PetroFed said.
The government, it said, has been garnering additional revenues through successive increases in excise duty on petrol and diesel during the last one year.
"Petroleum sector is already contributing to the government exchequer in a big way in this regard and therefore it is urged that it may not be saddled with any additional burdens like cess on domestic crude oil or customs duty on imported crude oil," it added.
Oil companies, the association said, have slated large capex spend in the next few years to meet the growing demand of the economy as also to provide for stringent fuel quality specifications mandated by the government.
"Considering the investment plans of refining companies, the costs that are not pass through in prices (like VAT on crude oil) already being borne by them and the current burden of steep and continuous fall in oil prices, the refining companies shall not be able to absorb any additional costs such as imposition of customs duty on crude oil," it said.
(Disclosure: Reliance Industries operates Network18, which owns Moneycontrol.com and other digital, print and TV channels).
On the other side, the exchange will remove countr
The Cabinet Committee on Economic Affairs yesterda
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The company's head of refineries told Reuters in a
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Hi Guest, welcome to the TES Community!
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Help with Rising Stars Levels - Maths Year 3 Autumn Test A1 and B1
Discussion in 'Primary' started by abster1, Oct 13, 2013.


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Flight Schedules from Tacloban to Ozamis
Find cheap airfares for flights from Tacloban to Ozamis. Use Wego.com to search and compare low airfare airline tickets for Tacloban to Ozamis flights on various international airlines. FInd last minute flights and the latest low airfares for this route. Compare cheap Tacloban to Ozamis flights at a glance and get the best deal for your trip.
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I tried the stock ASG-2 cable ($40?), Moon Audio Silver Dragon ($175), Chris_Himself pure silver ($200), and the silvergold uber cable ($1300?).
I actually liked Chris_Himself's pure silver cable best. But the sulvergold cable I tried didn't look like the one that eke tried... so it might have been the older version which he didn't like (and I didn't like it either). It would be interesting to try the updated version, which eke seems to love.
Sorry my mistake. I think I got confused by kuuketsuki's earlier post about the silvergold uber cable which costs $1300? I did a quick check on Musica Acoustics website on the 1plus2 and there are supposedly 3 types of cables - SILVER, GOLD and UBER. The silver cable comes default with the IEM and the gold cable costs 200 USD more than the silver with the IEM. You can also buy the gold cable separately for 795 USD (ouch) and you need to contact them for the uber cable's price (1300 USD? uber ouch). If you are going to buy the IEM, get the gold cable. Definitely not worth buying the gold cable on its own. I also heard from somewhere that the uber cable is not very flexible (brittle) and is not really suited for mobile outdoor use? Is the gold cable pure OCC gold throughout or is it an OCC silver electroplated with gold (or like those silver with 1% amalgamated gold)? If it is not pure gold, I wonder if other aftermarket cables like the Whiplash TWag v2 gold gives a similar performance as the Tralucent gold cable.


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Today's Devotional
Not about FameHow has Jesus changed your life?
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South Africa has been called the adventure capital of the world, with its natural beauty and wildlife that leaves visitors awe-struck. The rich culture, the freedom stru...abroaderview2010-10-01T22:59:582,620 views00:03:28


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PHP / Mysql programmer needed for small project
This project received 23 bids from talented freelancers with an average bid price of $343 USD.Get free quotes for a project like this
Project BudgetN/A
Total Bids23
Project Description
Basic e-commerce site with Javascript functionalities. Web pages already designed and constructed with advanced CSS. PHP/MySQL Programmer needed to construct Database for small shopping cart with back-end and payment processor. There will be country i.p. detection for redirection to u.s. or canada pricing models.
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Hebrews 7:4-10New King James Version (NKJV)
4 Now consider how great this man was, to whom even the patriarch Abraham gave a tenth of the spoils. 5 And indeed those who are of the sons of Levi, who receive the priesthood, have a commandment to receive tithes from the people according to the law, that is, from their brethren, though they have come from the loins of Abraham; 6 but he whose genealogy is not derived from them received tithes from Abraham and blessed him who had the promises. 7 Now beyond all contradiction the lesser is blessed by the better. 8 Here mortal men receive tithes, but there he receives them, of whom it is witnessed that he lives. 9 Even Levi, who receives tithes, paid tithes through Abraham, so to speak, 10 for he was still in the loins of his father when Melchizedek met him.
New King James Version (NKJV)
Scripture taken from the New King James Version®. Copyright © 1982 by Thomas Nelson. Used by permission. All rights reserved.
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"What we've got here is failure to communicate."
On the chain gang, they'd seen every kind of man...but Luke became a legend.
Sometimes, "Nothing" can be a really Cool Hand.
No one can eat fifty eggs.
The man...and the motion picture that simply do not conform.
He was a cool customer. . .until the law made it hot for him!


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Life coaching
We are still dancing around the beginning of the month. September has just started, and yet the days seem to fly by faster and faster. Three months from now we will be smack in the middle of "holiday season", the end of the year so close we'll be able to taste the Christmas cookies or the New Year's champaign. What do you want your life to look like in three months? How will you set yourself up for success in the new year?
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Originally posted on Razzball Basketball | Last updated 11/22/12
The Pacers had an incredible night. Paul George scored 37 points, including 9 from downtown – yes, that's NINE – and threw in 4 rebounds and 4 assists. Roy Hibbert was unimpressed with George's performance, and decided to go with a very unusual triple double. In fact, it seems Hibbert was angry at field goals, shooting 3-12 but blocking 11 shots. And no, that's not a typo; he finished with 10 points, 11 rebounds and 11 blocks. Between George's 9 and Hibbert's 11, we will never forget. There are no games tonight (the NBA blew its load with 14 yesterday), and I will be busy eating food like any rational carbon based life form on Thanksgiving, so I won't be answering any questions today. However, since you're possibly Canadian and don't know why we are celebrating Thanksgiving a month too late, here are some highlights from last night: Greg Monroe – He played 30 1/2 min and produced 19 points, 8 rebounds, 3 assists, 2 steals. I don't really need to tout him, do I? Rodney Stuckey – Stuck
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Victoria Valentina & Maui Kane
This is Victoria Valentino fellas!! This girl has the most beautiful pair of natural juggs ever!!! We love her tits so we decided to give her the JF treatment. We fucked those tits hard and put a load on them. She loved it!!
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[PHOTO] Some PCI seedlings bloomed in Spring 2002 Australia | Sun, 30 Mar 2003 17:07:55" />
The 'names' are seedling numbers that locate their position in the garden.
E15C - not a great photo. Very weird blend of colours, and huge blooms.
E13C - Sorry if I have sent this before. I just love this one.
E1B - Again a bit difficult to see clearly, but this one has an all over
purple, with a very feint darker striping. Lovely form and substance, and
lots of bloom.
Cheers, Jan
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Berkley Tool Set with Pliers and Forceps
Berkley Tool Set with Pliers and Forceps From the brand that celebrates both tradition and innovation, Berkley's Classic Tools are designed to offer the angler a wide selection of high-performance products at a great value. The Berkley Tool Set with Pliers is a multi use tool that will help the angler complete tasks like change hooks, secure split shot and cut braided line quickly and easily. The perfect combo for a tool kit with the strong grip of the pliers combined with the precision that the locking foreceps provide.
* 8.5" and 6" precision pliers combo
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* Corrosion resistant
* Sheath and lanyard included
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Category Archives: jobs
Engineer Position in Bordeaux (Papyrii, Inscriptions, etc.) for the project PATRIMONIVM
The European funding scheme ERC Starting Grant rewards the most innovative research projects led by young researchers in all scientific areas. Among those selected for funding in the 2016 call, the project PATRIMONIVM, hosted by the University Bordeaux Montaigne, aims … Continue reading
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Post-Doctoral Fellowship in the Culture and Ideology of Writing in the Ancient Mediterranean, Brown University, Providence, Rhode Island (USA)
Post-Doctoral Fellowship in the Culture and Ideology of Writing in the Ancient Mediterranean, Brown University, Providence, Rhode Island (USA) BrownPostdoc
PhD studentship on Early Greek Alphabet, Cambridge
Posted for Philippa Steele: The Faculty of Classics, University of Cambridge, is pleased to announce a fixed term fully-funded PhD Studentship on the European Research Council funded Project Contexts of and Relations between Early Writing Systems (CREWS). Further information is … Continue reading
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Postdoctoral Research Fellow (Facilitating Access to Latin Inscriptions), Oxford
Postdoctoral Research Fellow (Facilitating Access to Latin Inscriptions) Faculty of Classics, Ioannou Centre for Classical and Byzantine Studies, 66 St Giles', Oxford, and Ashmolean Museum, Beaumont Street, Oxford Grade 7: £30,738 – £32,600 p.a. Applications are invited for a full-time … Continue reading
Posted in EpiDoc, jobs Tagged museums, public engagement Leave a comment
Post-doctoral Researcher in Greek and Roman epigraphy (one year)
Post-doc position in the project "Segregated or Integrated? – Living and Dying in the Harbour-city of Ostia, 300 BC and AD 700", directed by prof. Arja Karivieri (Stockholm university) The School of Language, Translation and Literary Studies at the University … Continue reading
Post-doc research position at the Austrian Academy of Sciences
The Institute for the Study of Ancient Culture of the Austrian Academy of Sciences (Vienna, Austria) is seeking applications for a full-time (40h/week) post-doctoral research position in the Division Documenta Antiqua, working group "History of Ancient Law and Papyrology" Application … Continue reading
Insegnamento di Epigrafia greca/Teaching position in Greek Epigraphy Scuola Normale Superiore, Pisa
Insegnamento di Epigrafia greca alla Scuola Normale Superiore di Pisa La Scuola Normale Superiore invita qualificati studiosi nel campo dell'Epigrafia greca a inviare espressioni di interesse in vista della possibile attivazione di una posizione a livello di professore associato presso la … Continue reading
Postdocoral Research Position at Vienna (Epigraphik / Documenta Antiqua)
Am Institut für Kulturgeschichte der Antike der Österreichischen Akademie der Wissenschaften ist die Stelle einer wissenschaftlichen Mitarbeiterin / eines wissenschaftlichen Mitarbeiters in der Arbeitsgruppe Epigraphik der Abteilung Documenta Antiqua (Beschäftigungsausmaß 40 Wochenstunden) zu besetzen. Weitere Informationen hier
Digital Archive of Greek Historical Inscriptions (job)
Università di Venezia has advertised a position for an experienced researcher to work for one year on Greek Epigraphy in the project "Axon: a digital Archive of the Greek Historical Inscriptions" further details on Euraxess and the University web site.
Funded PhD in Ancient History, Fribourg (Switzerland)
Posted for Fabienne Marchand Fully funded PhD position in Ancient History at the University of Fribourg (Switzerland) A doctoral studentship associated with Old and New Powers: Boiotian International Relations from Philip II to Augustus, a project funded by the Swiss National … Continue reading
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Job vacancy: Postdoctoral Research Assistant, University of Warwick/Centre for the Study of Ancient Documents, Oxford
A Postdoctoral Research Assistant post has arisen at the University of Warwick for the 'Facilitating Access to Latin inscriptions in Britain's Oldest Public Museum through Scholarship and Technology' project, which explores the place of Latin literacy in Britain, the role … Continue reading
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Postdoc position, Greek inscriptions of Ptolemaic Egypt (Oxford)
A position is about to be advertized in Greek epigraphy at Oxford, with a salary that would probably suit a newly qualified postdoc. This project looks like it will join the many other excellent EpiDoc corpora produced by the Oxford … Continue reading
Position: Postdoctoral Research Fellow: Facilitating Access to Latin Inscriptions, Oxford
Posted for Alison Cooley: Postdoctoral Research Fellow (Facilitating Access to Latin Inscriptions) Ioannou Centre, 66 St Giles', Oxford Grade 7: £31,331 p.a. The 'Facilitating Access to Latin Inscriptions in Britain's Oldest Public Museum through Scholarship and Technology' project is seeking … Continue reading
Advertisement: position in Information Studies (TVL 13) at Heidelberg University (EDH / Seminar für Alte Geschichte und Epigraphik)
In the Seminar für Alte Geschichte und Epigraphik of Heidelberg University, Research projekt Epigraphische Datenbank Heidelberg (EDH / HAW), there is a position to be filled in Information Studies (E 13 TV-L, from 01.04.2013 to 31.03. 2016). Application until 21.01.2013. … Continue reading
A post-doctoral fellowship in Bologna
This is a call for applications to a post-doctoral one year fellowship in Greek Epigraphy, starting from March 1, 2012. Applications must be submitted by Jan. 31, 2012, according to the "Bando" on University of Bologna website (Dipartimento di Storia … Continue reading
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LeeAnneModel Female Montreal, Quebec, Canada
My MM URL: http://www.modelmayhem.com/leeannfitz
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About MeHi, my name is Lee-Ann. I'm an aspiring model from Québec, in Canada. I have a little experience and have done a couple of shootings, but I'm on this site hoping I could do more to gain some more experience. :)
I am also an aspiring photographer. I will post my work soon.
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Pelvic Pain ManagementOxford University Press 2016; US$ 67.99
Pelvic Pain Management is an evidence-based guide to understanding the basics of pain mechanisms, pharmacology, invasive and noninvasive treatment modalities, and pain management protocols related to the complex problem of pelvic pain. more...
Multimodality Imaging Guidance in Interventional Pain ManagementOxford University Press 2016; US$ 249.99
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The Permanent Pain CureMcGraw-Hill Education 2008; US$ 18.00
Are you taking medication or considering surgery because of pain? Have you lived with low-level muscle or joint pain for years? Imagine your life today without pain. Imagine you hold the key to eliminating any future pain. Find it inside this book: a groundbreaking drug- and surgery-free healing plan from master pain therapist Ming Chew. The Ming... more...
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Living with Chronic Pain, Second EditionHatherleigh Press 2009; US$ 12.99
Chronic pain is a condition that afflicts over 50 million Americans. Chronic pain can be a symptom of a variety of illnesses, injuries, or chronic conditions. From back pain to migraine headaches to arthritis, from sports injuries to cancer, chronic pain can afflict anyone at any age. It is one of the most frequently under-treated conditions and,... more...
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Immer mehr Patienten vertrauen in der Schmerztherapie neben der Schulmedizin auch auf komplement�re Methoden. Beide Richtungen k�nnen zum Wohl des Patienten in vielen Therapieverfahren eingesetzt werden. Dieses von Experten aus Pflege und Medizin geschriebene Buch bietet einen guten �berblick zu den h�ufigsten Methoden. Neben den Grundlagen �ber... more...
Clinical Pain Management Second Edition: Chronic PainCRC Press 2008; US$ 115.95
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People who, like myself, had never heard of author Elizabeth Gaskell or Cranford have quite a treat waiting for them upon their first viewing of the new television mini-series based upon her work. People who were already fans of the Victorian-era writer will, I think, be immensely pleased at the cinematically "elegant economy" with which BBC has delineated the subtle strokes of Gaskell's pen.
To the citizens of Cranford, a fictional town based upon the real village of Knutsford in Cheshire, England, "elegant economy" is as much a way of life as how and when to pay a social call, and whether or not a cow is essential but a "gig" (dandified carriage) is vulgar.
The arbitress of propriety in this bucolic town is Miss Deborah Jenkyns (Dame Eileen Atkins of Cold Comfort Farm and Gosford Park). The elder sister of Miss Matilda (Matty) Jenkyns, Miss Deborah has never forgotten the lessons she learned as the daughter of the village rector. The ladies of a certain age whose social set dominates Cranford mores and customs all look to Miss Deborah for her superior wisdom. Whether to burn one candle or two and how many days before one returns a social call are serious questions, and their apt resolution is a solemn matter in Cranford.
Matty Jenkyns (Dame Judi Dench) is all too content to defer to her sister on every matter of import. And so it went without question that she had to dissuade her sole suitor and co-exists with Miss Deborah as spinsters in their autumn years. The women of Cranford assist townsfolk and each other in any way possible, however, so no one need feel at the mercy of life. The ladies of Cranford – genteel of lineage if lacking material wealth – have mercy stockpiled. We see several times in the story that in the direst of times they have kindness to spare.
Elizabeth Gaskell wrote her novels during the Victorian age. Women in those days were often seen as inferior creatures lacking a male's rational sensibility and also his superior physical strength. Class distinctions were severe in that time as well. One born into poverty had a very small chance of changing their fate in their lifetime. It was in this setting Gaskell, the daughter and later a wife of Unitarian ministers, set about threading her novels with the notion of social change and 'equality for all' the same way the ladies of Cranford might work at needlepoint quietly by candlelight. Or – perhaps – the way the silent order of nuns in France might work a piece of lace.
And so in this three-part BBC filmed series we see dollops here and there of social firebranding. It is to scriptwriter Heidi Thomas's credit that it very rarely stands out or feels heavy-handed. Only in one instance, actually, does one wonder if something has been modernised. The female clerk ranting at her male boss that one day women will work in any profession seems a bit anachronistic. Since I haven't read the novella (My Lady Ludlow) that subplot is taken from, I honestly can't say whether that was a creation of the screenwriter or of Gaskell herself. It's certainly possible it was Gaskell, who counted social reformers such as Harriet Beecher Stowe and Florence Nightingale among close friends. But to be frank, either way the scene feels a bit top-heavy and unrealistic in that moment.
Aside from that one tiny flaw – and a bit of a simpering romantic storyline between a young doctor and a blond, ringleted ingenue, which many viewers may find delightful and refreshing – the three parts comprising the Cranford mini-series are spectacular. In a quiet, tasteful manner, of course.
Dame Eileen Atkins is astonishing as Miss Deborah. Infinitely compassionate yet austere in her social judgments, Atkins shows us a woman who sees everything and is fooled by nothing. Dame Atkins must do most of this communicating with her eyes, and as all great actors are, she is a master of this. One sideways glance says more than a thousand-word monologue spouted by a lesser talent. Part one of this mini-series is dominated by Miss Deborah and I relished every single moment.
Dame Judi Dench (there's nothing like a Dame!) is also stellar as Miss Matty. I had read most of the novel Cranford before viewing the screener of the filmed version, and I had imagined Miss Matty as being very delicate, breathy and nearly ghostlike in her dependence and deference. When I realised Dame Dench would portray her I wondered how the Queen of England twice over could possibly suit as the wisp of a self-effacing maiden lady Miss Matty should be. Silly me.
Dame Atkins in all her wispy physicality and Dame Dench in her stolid and solid form, somehow transform themselves into the essence of natural strength and of faintly fragile frailty as if Pygmalion had switched their souls. The program is worth watching solely for this feat, but there is so much more to its merit.
The supporting cast is also incredible. I've run out of Dames (for the moment – I would not be surprised if that changed by press time), but the actors are of such uniform excellence the level of quality in this film builds upon itself until I was practically ready to shout from my window: "Watch Cranford; watch Cranford!" It took two complete viewings before I realised the slightly forlorn, emphatically loyal, highly moral Mr. Carter was played by none other than crass, brash Chief Detective Gene Hunt of the police drama, Life On Mars. The articulation – especially physically – between the two portrayals is starkly different. In Mr. Carter, chief assistant to aristocracy, actor Philip Glenister creates an astounding homage to a man so conscientious he willingly risks all for others' sakes. As with virtually all of the performances in the Cranford series, Glenister creates the supreme illusion — that his character actually lives.
Gaskell's writing was artful as well; she not only pulled the reader deftly into the world she created within her pages, she kept them there. Her hand was so light, she could satirise with love and scold with affection and one never feels preached to. It is a sincere distinction that the script, direction, and acting which comprise the filmic version of Gaskell's titular novel and assorted shorter works achieve the same. Simply put, one cares deeply about every citizen of Cranford-near-Manchester (that heaving metropolis), from the squatter family in the woods to the Lady of the Manor they feel forced to poach game from. And if one laughs along with any of them or even, sometimes, at them, it is with the highest simultaneous regard – as with people one actually knew and grew to cherish. So it may not be astonishing if at some point, the viewer actually finds oneself crying alongside them, as well.
The various ladies who make up the social whirl of this small town are written and acted with such subtle detail they spring to life off the screen. One feels one knows them and could write a letter to Cranford – or receive one, and read about a shocking risk of delicate lace (and its messy rescue), or perhaps be riveted by tales of the new spring muslins "direct from Paris". Imelda Staunton (Sense and Sensibility, Peter's Friends) is simultaneously hilarious and maddening as Miss Pole. Miss Pole's bonnet feather dances up and down the side streets of Cranford eavesdropping or racing to share the latest overheard emergent scandal. Whether her report is accurate or not is hardly of import.
Julie Sawalha ("Saffie" from TV's comedic Absolutely Fabulous) brings sentiment but not bathos to Jessie Brown, the eternally self-sacrificing daughter whose family has seen much tragedy. We pull for her to finally get some just return, for all the love she has shown others. Deborah Findlay and Selina Griffiths are Miss Jessie's polar opposites as the slightly self absorbed and scheming Tomkinson sisters. Lisa Dillon is sensible and steady as Mary Smith, a relative boarding with Miss Deborah and Miss Matty. Her character is a unifying thread throughout the three parts of this series and is likely based upon author Gaskell herself. Mary narrates the novel version of Cranford, and Elizabeth Gaskell's early life played parallel to much in the novel, including being shipped off to live with relatives due to her own mother's death.
Alex Jennings portrays the Reverend Hutton with a suitable combination of dignity and humility. It is to every actor's great credit here that none seeks to overshadow or chew scenery but plays their part as the standing of the character actually requires. Which brings us to Her Ladyship Ludlow and the peasant boy whose social climbing – for sheer drive to learn everything he can about the world – unravels her, perhaps to her betterment. Francesca Annis' portrayal of Lady Ludlow is such that her voice and movements seem slowed as if she cannot quite allow herself to wake. The costuming given Annis enhances the storytelling: Lady Ludlow appears caked in frost and dust, as if she sleeps in that underground ice cave she owns. Frozen in grief, Her Ladyship sends money to a profligate son for his extravagances abroad. He is her last surviving heir, who will likely never return until she is dead, and then only to collect his inheritance.
Alex Etel deserves special mention as Lady Ludlow's innocent foil, the little peasant boy Harry Gregson. Upon first viewing Cranford, I was so caught up in the Gregson-Carter-Ludlow plot line I felt what the characters must be feeling. Then at some point watching the second time, during which I was also watching the response of the person watching alongside me and so perhaps had a more objective placement in the relationship between a work of art and the viewer, it suddenly hit me like a ton of bricks: Not only is this child acting – he's a child. Somehow this actor in his short lifetime already knows how to breathe life into a character with subtlety, restraint and realism. Etel truly possesses an astonishing talent and is one to watch for in years to come.
The minor characters are also uniformly excellent: Hannah Stokely is stubborn, staunch, and smarter than given credit for, as the Jenkyns' young maid Bessie. Andrew Buchan is her handsome but somewhat hapless 'follower', Jem Hearne. Lesley Manville does a good turn as the bewildered housekeeper Mrs. Rose. Simon Woods and Kimberley Nixon are blond.
The lives, loves, and losses of Cranford are shown us in three parts airing on PBS' Masterpiece Theater Classics beginning Sunday May 4. Parts two and three air the consecutive Sunday evenings after that, May 11 and May 18. The creators of this mini-series (Sue Birstwistle and Susie Conklin) and all who took part in it have forged onto film a place so real and so delightful I wish I could vacation there. I wouldn't mind Miss Pole spreading gossip about me, or town snob Mrs. Jamieson (actress Barbara Flynn) looking down her nose at me. I will ration the candles, and practise elegant economies. I don't mind privation in place of material comforts. Just let me spend time in a place where everyone truly cares about everyone else. Let me go to a place where, when the tragic surprises in life occur, someone will happily give their best to help.
It isn't possible to buy a ticket to Gaskell's charming village, and anyway, the railway will be the death of its time-honored customs. So I will do the next best thing – and I urge you to join me. See Cranford, see Cranford, see Cranford.


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CD4+ helper T (TH) lymphocytes are essential organizers of adaptive immune responses and key mediators in immune-mediated inflammatory and allergic diseases. Upon activation by antigen-presenting cells (APC), naive TH cells undergo clonal expansion and functional differentiation into cytokine-secreting effector cells. Effector TH cells have been historically classified into TH1 and TH2 subsets. Recently, a novel TH subset, named TH17, that makes IL-17 has been identified by our and other groups. In the last funding cycle, we have investigated the molecular programs governing TH17 differentiation. We have identified key function of STAT3 in mediating cytokine-regulated TH17 differentiation. We further showed that STAT3 is required for upregulation of two TH17-specific orphan nuclear receptors RORa and RORg and that these two factors play synergistic and somewhat redundant function in TH17 differentiation. We also reported that RORa and RORg function in activating the transcription of IL-17 and IL-17F genes, two related cytokine genes but with differential in vivo function, and that the CNS2 element in IL-17-IL-17F gene locus enhances ROR-dependent transcription of IL-17 gene promoter in a reporter assay. Furthermore, we show that Foxp3+ Treg and TH17 cells exhibit antagonistic regulation yet with functional plasticity in vitro and in vivo. Smad2 and Smad3 molecules, both of which are activated by TGFb signaling, differentially regulate Treg and TH17 cell differentiation. Despite these achievements, there are still remaining questions about the transcriptional regulation in TH17 cells. First, are RORs important for maintaining cytokine transcription in mature TH17 cells? Second, how do RORs regulate the transcription of the IL-17 and IL-17F genes? Thirdly, considering RORs associate with various co-activators for their function, what co-activators are required for TH17 cell differentiation? We will pursue these questions in the proposed grant. First, we will determine the function of RORg and RORa in mature TH17 cells and in Treg cells. Secondly, we will examine how RORs regulate TH17 cytokine transcription. We will identify additional elements that may be also required for IL-17F transcription. Lastly, we will genetically analyze the functio of SRC molecules in TH17 differentiation. We will investigate their function and regulation during TH17 cell differentiation in vitro and in vivo. Overall, the proposed project will center on the transcription factors that were shown in the previous cycle to be crucial in TH17 differentiation. We will analyze the biological function of these factors as well as the mechanisms underlying their function. These studies will further substantiate our understanding on these important regulators and facilitate ongoing efforts in targeting these pathways in treatment of human diseases.
Recently, a novel TH subset, named TH17, has been identified to play critical roles in inflammatory diseases. Our proposal is to study the roles of TH17-specific transcription factors RORa and RORg in T cells and the underlying mechanisms. Our work will advance our understanding on these important factors and facilitate ongoing efforts in targeting these pathways in treatment of human diseases.
|Liu, Xindong; Chen, Xin; Zhong, Bo et al. (2014) Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature 507:513-8
|Liu, Xindong; Nurieva, Roza I; Dong, Chen (2013) Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev 252:139-45
|Wang, Aibo; Pan, Deng; Lee, Young-Hee et al. (2013) Cutting edge: Smad2 and Smad4 regulate TGF-*-mediated Il9 gene expression via EZH2 displacement. J Immunol 191:4908-12
|Liu, Xikui; Li, Hongxiu; Zhong, Bo et al. (2013) USP18 inhibits NF-*B and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med 210:1575-90
|Nurieva, Roza I; Podd, Andrew; Chen, Yuhong et al. (2012) STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem 287:11234-9
|Chung, Yeonseok; Tanaka, Shinya; Chu, Fuliang et al. (2011) Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17:983-8
|Chang, Seon Hee; Dong, Chen (2011) Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal 23:1069-75
|Angkasekwinai, Pornpimon; Chang, Seon Hee; Thapa, Manoj et al. (2010) Regulation of IL-9 expression by IL-25 signaling. Nat Immunol 11:250-6
|Peng, Juan; Yang, Xuexian O; Chang, Seon Hee et al. (2010) IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res 20:62-71
|Chang, Seon Hee; Chung, Yeonseok; Dong, Chen (2010) Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem 285:38751-5
Showing the most recent 10 out of 31 publications


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Community Foundation Awards $125,000 to Organizations Serving People with Disabilities
The Community Foundation for Southeast Michigan continues 25th anniversary celebration by awarding grants totaling $125,000 to 50 nonprofit organizations that serve people with disabilities throughout the region.
The Community Foundation for Southeast Michigan (www.cfsem.org)
The organizations, which serve individuals with hearing, vision, developmental and other physical disabilities, each received a grant of $2,500 for operating support.
"There are many organizations in our region that provide essential and critical services daily to people with disabilities,"
"The Community Foundation holds several endowment funds which are dedicated to improving the lives of persons with disabilities,"
The Community Foundation is marking its 25th anniversary by bringing visibility to the hundreds of organizations that are important to the quality of life of all residents in southeast Michigan. To date, during its anniversary year, the Community Foundation has made twenty-five $25,000 grants to provide needed operating support to a wide range of organizations and helped secure more than $5 million for 75 arts and cultural organizations through the Community Foundation Challenge – Arts & Culture. The 50 grants awarded today to the organizations serving individuals with disabilities highlight the importance of services to an under-recognized part of our community.
Following are comments from several of the organizations that received grants:
*Kurt Sebaly, Executive Director, Penrickton Center for Blind Children
"The children at Penrickton Center for Blind Children are challenged each and every day to develop and become as independent as possible. This unexpected, and much appreciated, gift provides encouragement and hope for our children and families."
*Karen Schrock, President and CEO, Adult Well-Being Services
"For the past 56 years, Adult Well-Being Services has focused on helping people live as independently as possible, regardless of their ability. We are proud to serve the growing number of people with developmental, mental and physical disabilities in southeastern Michigan."
*Mike Wooley, President and CEO, The Detroit Institute for Children
"In this current economic environment, this support will directly impact the lives of low income and underinsured children facing numerous special needs by providing much-needed therapeutic services. This grant means that each of our kids can reach their fullest potential, and, on their behalf, I could not be more grateful."
*Richard Loewenstein, Chief Executive Officer, JARC
"JARC is an integral part of the community. We provide a lifelong relationship for people with developmental disabilities. I think it is very important for the general public to get a better understanding of the disability community. I think that it adds to the lives of the people with disabilities, but more importantly it adds to our own lives when we reach out and include people with disabilities in our daily lives."
The Community Foundation recognized organizations from throughout its seven-county region that provide essential services to people who have disabilities. The organizations that received $2,500 grants include:
Organization – City – Web Site
• Adult Well-Being Services – Detroit – http://www.awbs.org
• Angels' Place – Southfield – http://www.angelsplace.com
• Birmingham Public Schools – Birmingham – http://www.birmingham.k12.mi.us/
• Cass Community Social Services – Detroit – http://casscommunity.org
• Children With Hair Loss, Inc. – South Rockwood – http://www.childrenwithhairloss.us
• Children'
• Children's Hospital of Michigan – Detroit – http://www.childrensdmc.org
• Deaf and Hearing Impaired Services – Farmington Hills – http://www.dhisonline.org
• Deaf Community Advocacy Network Inc. – Sylvan Lake – http://www.deafcan.org
• Deaf Options, Inc. – Redford – http://www.deafoptions.net
• Dearborn Public Schools – Dearborn – http://dearbornschools.org
• Detroit Institute for Children – Detroit – http://www.detroitchildren.org
• Detroit Public Schools – Detroit Day School for the Deaf-Detroit – http://www.detroitdayschoolforthedeaf.org
• Detroit Receiving Hospital – Detroit – http://www.drhuhc.org
• Garden City Public Schools – Burger School for Students with Autism-Garden City – http://www.gardencityschools.com
• Goodwill Industries of Greater Detroit – Detroit – http://www.goodwilldetroit.org
• Greater Detroit Agency for the Blind and Visually Impaired – Detroit – http://www.gdabvi.org
• Henry Ford Health System-Center for Vision Rehabilitation & Research – Detroit – http://www.henryfordhealth.org
• Huron Valley Schools – Highland – http://www.huronvalley.k12.mi.us
• JARC – Farmington Hills – http://www.jarc.org
• Judson Center – Royal Oak – http://www.judsoncenter.org
• Latino Family Services – Detroit – http://www.latinofamilyservices.org
• Lions Hearing Center of Southeast Michigan – Detroit – http://www.lhcmi.org
• Livonia Public Schools – Livonia – http://www.livoniapublicschools.org
• Macomb Intermediate School District – Clinton Township – http://www.misd.net
• Macomb-
• Michigan Association for Deaf and Hard of Hearing – Lansing – http://www.madhh.org
• Northville Public Schools – Northville – http://www.northville.k12.mi.us
• Oakland University-OU CARES – Rochester – http://www.oakland.edu/
• On My Own of Michigan – Troy – http://www.onmyownofmi.org
• Optometric Institute and Clinic of Metro Detroit – Detroit – http://optometricinstitute.org
• Penrickton Center for Blind Children – Taylor – http://www.penrickton.com
• Seedlings Braille Books for Children – Livonia – http://www.seedlings.org
• Services to Enhance Potential – Dearborn – http://www.stepcentral.org
• Special Olympics Michigan – Mount Pleasant – http://www.somi.org
• St. John Health-Holley Institute – Detroit – http://www.stjohn.org/
• StageCrafters – Royal Oak – http://www.stagecrafters.org
• The Arc of Dearborn/Dearborn Heights – Dearborn Heights – http://www.arcmi.org/
• The Arc of Detroit – Detroit – http://thearcdetroit.org
• The Arc of Livingston – Howell – http://www.arclivingston.org
• The Arc of Macomb – Clinton Township – http://www.arcservices.org
• The Arc of Downriver – Wyandotte – http://downriverarc.org
• The Arc of Northwest Wayne County – Redford – http://www.thearcnw.org
• The Arc of Western Wayne County – Westland – http://www.thearcww.org
• The Guidance Center – Southgate – http://www.guidance-
• United Cerebral Palsy Association of Metropolitan Detroit – Southfield – http://www.ucp.org/
• Wayne Center – Detroit – http://www.waynecenter.org
• Wayne State University-Detroit Radio Information Service – Detroit – http://www.wdetfm.org/
• Wild Swan Theater – Ann Arbor – http://www.wildswantheater.org
• Wyandotte Public Schools-The Lincoln Center – Wyandotte – http://lincoln.wyandotte.org
# # #
The Community Foundation for Southeast Michigan is a permanent community endowment built by gifts from thousands of individuals and organizations committed to the future of southeast Michigan. The Foundation works to improve the region's quality of life by connecting those who care with causes that matter. The Foundation supports a wide variety of activities benefiting education, arts and culture, health, human services, community development and civic affairs. Since its inception, the Foundation has distributed more than $390 million through more than 34,000 grants to nonprofit organizations throughout Wayne, Oakland, Macomb, Monroe, Washtenaw, St. Clair and Livingston counties. For more information, please visit www.cfsem.org.
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Zenefits Said to Be Worth $500 Million in Latest RoundSarah Frier
Zenefits, a year-old startup that makes human resources software, is valued at $500 million after its latest found of fundraising, according to people familiar with the matter.
The round, led by Andreessen Horowitz, generated $66.5 million to bring Zenefits' total funding to $84 million. The valuation jumped from $45 million four months ago, when Zenefits attracted its previous investments, the people said.
The company could be one of the fastest-growing business-services software providers, with plans for revenue to increase 1,300 percent this year, San Francisco-based Zenefits said in a statement today.
Zenefits doesn't need the money immediately but took the opportunity to raise it now, Chief Executive Officer Parker Conrad said in an interview.
"We had just a ton of interest from investors," Conrad said. "We knew we were going to have to raise again at some point this year to fund growth in 2015. We thought, maybe we could raise today and do it on really good terms."
Zenefits is one of several startups with expanding values. Pinterest Inc. recently raised $200 million in a financing that gave it a $5 billion valuation, up from $3.8 billion seven months earlier. Uber Technologies Inc. is in talks to raise funds that could value it at about $17 billion, compared with $3.5 billion last year. Others, including Dropbox Inc. and Airbnb Inc., have attracted investments boosting their values to $10 billion.
Boosting Sales
Zenefits automates human resources functions, from payroll to benefits, in a cloud-based application. The software is free, and Zenefits makes money when clients hire the company as their health insurance broker. It's working with more than 2,000 companies, it said in the statement.
With 130 employees, up from 15 in December, Zenefits is almost too big for the office space it moved into five weeks ago, Conrad said. While negotiating for more room, the company plans to boost its sales and customer support teams and have more than 200 employees by the end of the year, he said.
"They've completely outperformed the business case that they presented, which doesn't happen very often," said Lars Dalgaard, a partner at Menlo Park, California-based Andreessen. He said its clients include "everything from steel mills to charter schools and even a circus."
Among the round's investors were Institutional Venture Partners, SV Angel, Hydrazine Capital, Elad Gil and actor Jared Leto. Bloomberg LP, the parent of Bloomberg News, is an investor in Andreessen Horowitz.


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Each month you'll have the chance to send us your story on how you are being an innovative Family and Consumer Science teacher. We'll pick one winner and we'll write an article that will appear on the front page of the site describing who they are and what makes them an innovative Family and Consumer Science Teacher!
Some restrictions apply; you must be over 18, be a family and consumer science teacher, and be a US resident. Entries must be emailed to email@example.com and include a write up about yourself answering the questions below as well as a minimum of two pictures one of you and at least one of your student's projects. You may not submit pictures of students since the pictures would require students' consent to publish on the internet. Video entries are encouraged and can be submitted by first uploading them to You Tube then sending a link to your video in an email. Entries will be accepted until midnight, the last day of every month.
Please send us an email answering the following questions:
- Your Position (high school, middle school, post secondary)
- State you teach in
- How long you've been teaching & why you enjoy teaching FACS
- Give at least one example of the innovative teaching strategies or lessons that you have employed.
- Describe how you keep up with the latest trends in Family and Consumer Sciences.
- Any other stories or commentary about your teaching experience (optional)
- Include at least two pictures including one of you OR submit your answers via a short video uploaded to YouTube.
Email Your Entry To: firstname.lastname@example.com
FamilyConsumerSciences.com in its sole discretion will choose a winner based on having met the criterion stated above.


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post #1 of 6 Old 02-22-2007, 10:22 PM Thread Starter
red betta
red betta and a new digital camera :)
post #2 of 6 Old 02-22-2007, 10:35 PM
Sent from my desktop or phone or whatever else I am holding on to
I'm ready for the pressure.
The drama and the pleasure!
If there is one thing I want to see here, it's HUMOR.
I believe I can fly!
I believe I can touch the sky!
I think about it every night and day!
I stand in awe of my body.
post #3 of 6 Old 02-22-2007, 11:13 PM
Aww, that fish is the spittin' image of my betta--Rex. I seem to be getting more and more fond of bettas, great fish
post #4 of 6 Old 02-23-2007, 08:44 AM
ive had bettas alot throughout the years but am appreciating them more and more latley. this one looks exactly like one i have except mines crown tail. i saw a beautiful smoky blue one the other day that i really wanted but couldnt convince my husband. that betta pic is great! :D
post #5 of 6 Old 02-24-2007, 05:45 PM Thread Starter
the best one ive EVER seen was emerald green ive never seen a green one before or since
post #6 of 6 Old 02-24-2007, 06:33 PM
hes a cutie, i once saw an albino freeky one
About As Innocent As a Nun In a Cucumber
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What is Anemia?
What is Anemia and Why Am I Tired?
Reprinted with permission from DaVita, Inc.
Someone with chronic kidney disease (CKD) may also have anemia, a condition that results when red blood cell levels fall below normal ranges. A major factor in the development of anemia for those with CKD is the diseased kidneys' inability to produce erythropoietin (EPO), a hormone which stimulates the production of red blood cells in your bones. Anemia is a condition that can be diagnosed and treated.
To understand anemia, it's important to understand how your blood cells function. Your body contains two types of blood cells: white and red. White blood cells help fight infection, while red blood cells transport oxygen throughout the body. Red blood cells contain a protein called hemoglobin, which combines with the oxygen and releases it to your tissues. When your body is low in red blood cells and hemoglobin, you're said to be anemic. Because of the lack of oxygen in your bloodstream, you may find that you feel very tired.
How does kidney disease contribute to anemia?
There is a link between kidney disease and anemia. Red blood cells are made in your bone marrow. When your kidneys are functioning properly, they release the hormone erythropoietin (EPO), which in turn stimulates the bones to make red blood cells. However, when you have chronic kidney disease, your kidneys may not be able to produce a normal amount of EPO, and anemia results. As your kidney function declines, you may slowly develop anemia and not even be aware of it. This occurs at different times for different people, but once you reach Stage 3 of chronic kidney disease, you are likely to experience some degree of anemia.
The other contributing factor to developing anemia is a lack of iron.
Symptoms of Anemia
Some of the symptoms of anemia are as follows:
- Looking pale or "washed out"
- Tiring easily
- Heart palpitations (racing heart)
- Shortness of breath
- Hair loss
- A general sick feeling or sluggishness
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Recipe Shuffle
Minted Green Pea Soup Grilled Chicken Salad with Raspberry Vinaigrette Blueberry Lemon Fruit Topping Asparagus Salad with Vinaigrette Breakfast on a Stick Cauliflower With Cheese Sauce (Gluten Free) Mini Meatballs Linguine with White Clam Sauce Chili-Lime Corn on the Cob Fusilli with Tomatoes and Corn
As I mentioned in an earlier post, one of the benefits that made it cost-effective for me to go with the real healthcare (HSA) plan rather than the phony (HRA) plan is that my company is now covering "preventative" medicines at $0 copay. The formulary for these, as stated by CVS/Caremark (my pharmacy benefits provider), covers all test strips, lancets, and control solutions. I dutifully get my doctor to write up prescriptions for all of my testing needs, submit...


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This squeezable custom water bottle holds 28 oz. of your cool drink and is made of durable, impact-resistant, BPA-free plastic that does not retain odor or taste.
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Redoxon Double Action Effervescent Tablets 10s gives your body a first line defence to fight off and prevent troublesome infections such as colds, flu and fever. Clinically made with a dual-action formula, Redoxon tablets synthesise a powerful combination of vitamin c and zinc, which work to combat free radicals and support immune defence. Perfect for when you're not feeling your best, these tablets easily dissolve to give you a drink that's both beneficial to your health and deliciously tasty.
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Breakdown of the intestinal epithelial barrier represents an early and important manifestation of various gastrointestinal disorders including inflammatory bowel disease. The integrity of the epithelial barrier is regulated by cellular structures known as tight junctions (TJs) and adherens junctions (AJs). Disruption of TJs and AJs underlies increased permeability of inflamed intestinal epithelium, whereas junctional reassembly is crucial for recovery of the epithelial barrier during mucosal restitution. Understanding mechanisms of AJ and TJ remodeling during intestinal epithelial damage and restitution represents the major goal of the proposed study. TJs and AJs associate with the actin cytoskeleton which is a crucial regulator of junctional reorganizations and integrity. Actin filaments are highly dynamic polymers undergoing a constant turnover (depolymerization and polymerization). Such a turnover of filamentous (F) actin is critical for a variety of cellular functions, however its involvement in AJ/TJ regulation remains poorly investigated. A central innovative hypothesis of this proposal implies that F-actin turnover plays a key role in reorganizations of epithelial AJs and TJs during mucosal damage and restitution. Particularly, I propose that accelerated turnover of perijunctional actin filaments mediates both AJ/TJ disassembly and reformation of nascent AJ-like junctions, whereas decreased F-actin turnover is prerequisite for the establishment of TJs and barrier resealing. This hypothesis will be tested in the following Aims: (1) To examine the role of actin filament turnover in disassembly and reformation of epithelial AJs and TJs;(2) to investigate the involvement of actin-depolymerizing factor (ADF)/cofilin proteins in junctional remodeling during intestinal epithelial damage and restitution;3) to analyze the role of F-actin cross-linking proteins in disassembly and reestablishment of epithelial junctions.
These aims will be accomplished using in vitro intestinal epithelial cell monolayers exposed to inflammatory mediators as well as in vivo mouse model of colitis and tissue biopsies of human patients. Turnover of actin filaments and functions of actin- depolymerizing and cross-linking proteins will be analyzed by a combination of biochemical (actin- monomer sequestration, immunoblotting, detergent fractionation), immunocytochemical and genetic (siRNA-mediated knock-downs, expression of dominant-negative or constitutively active mutants, knockout mice) approaches. Significance: the proposed study will provide new insights into fundamental mechanisms of intestinal mucosal injury during inflammation. Understanding these mechanisms will provide new therapeutic targets to prevent breakdown and enhance reparation of the gut barrier in patients with digestive diseases.
The proposed research is aimed to understand mechanisms underlying disruption and restoration of the intestinal epithelial barrier. The barrier breakdown is a common manifestation of different gastroenterological disorders including ulcerative colitis, Crohn's disease, celiac diseases and infectious colitis. Furthermore, dysfunctions of the gut barrier contribute to the development of other diseases such as septic shock, alcoholic liver disease and type I diabetes. This project will provide new insights into understanding the pathogenesis of gastrointestinal disorders by exploring a novel epithelium-related mechanism involving in initiation and/or exaggeration of mucosal inflammation. Furthermore, it may provide novel targets for pharmacological prevention of the intestinal barrier breakdown and for accelerated healing of the injured gut mucosa. This may result in decreased morbidity and mortality of a large cohort of patients with inflammatory disorders.
|Ivanov, Andrei I (2014) Pharmacological inhibitors of exocytosis and endocytosis: novel bullets for old targets. Methods Mol Biol 1174:3-18
|Lechuga, Susana; Baranwal, Somesh; Li, Chao et al. (2014) Loss of ?-cytoplasmic actin triggers myofibroblast transition of human epithelial cells. Mol Biol Cell 25:3133-46
|Naydenov, Nayden G; Feygin, Alex; Wang, Lifu et al. (2014) N-ethylmaleimide-sensitive factor attachment protein * (*SNAP) regulates matrix adhesion and integrin processing in human epithelial cells. J Biol Chem 289:2424-39
|Rezaee, Fariba; DeSando, Samantha A; Ivanov, Andrei I et al. (2013) Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol 87:11088-95
|Kuo, I-Hsin; Carpenter-Mendini, Amanda; Yoshida, Takeshi et al. (2013) Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. J Invest Dermatol 133:988-98
|Ghatak, Sayak; Reveiller, Marie; Toia, Liana et al. (2013) Bile acid at low pH reduces squamous differentiation and activates EGFR signaling in esophageal squamous cells in 3-D culture. J Gastrointest Surg 17:1723-31
|Ivanov, Andrei I; Naydenov, Nayden G (2013) Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies. Int Rev Cell Mol Biol 303:27-99
|Naydenov, Nayden G; Harris, Gianni; Brown, Bryan et al. (2012) Loss of soluble N-ethylmaleimide-sensitive factor attachment protein ? (?SNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi. J Biol Chem 287:5928-41
|Naydenov, Nayden G; Brown, Bryan; Harris, Gianni et al. (2012) A membrane fusion protein ýýSNAP is a novel regulator of epithelial apical junctions. PLoS One 7:e34320
|Rezaee, Fariba; Meednu, Nida; Emo, Jason A et al. (2011) Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells. J Allergy Clin Immunol 128:1216-1224.e11
Showing the most recent 10 out of 11 publications


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Becky Luigart-Stayner; Cindy Manning Barr
This quick and easy soup recipe features shrimp and whole-kernel corn and gets is creaminess from half-and-half. Serve with sliced baguette for dipping.
4 servings (serving size: 1 cup shrimp mixture and 1 tablespoon onions)
Nutritional Information
Calories 279
Caloriesfromfat 26 %
Fat 8.1 g
Satfat 3.6 g
Monofat 1.9 g
Polyfat 1.1 g
Protein 37.3 g
Carbohydrate 12 g
Fiber 2 g
Cholesterol 281 mg
Iron 4.3 mg
Sodium 741 mg
Calcium 149 mg
Cooking spray
1 1/2 pounds large shrimp, peeled and deveined
3/4 cup chopped green onions, divided
1/4 cup water
3/4 teaspoon Old Bay seasoning
1 (11-ounce) can extrasweet whole-kernel corn, drained
3/4 cup half-and-half
1/4 teaspoon salt
Heat a large saucepan over medium-high heat. Coat pan with cooking spray. Add shrimp to pan; sauté 3 minutes. Add 1/2 cup onions, water, seasoning, and corn; bring to a boil. Cover, reduce heat, and simmer 5 minutes.
Remove from heat; stir in half-and-half and salt. Cover; let stand 3 minutes. Sprinkle with 1/4 cup onions.
May 2004


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6 Weather Morning Forecast for Aug. 19, 2008
We will see plenty of sunshine to start out the day with a 10 a.m. temperature around 71 degrees. Expect a few more clouds in the afternoon leaving the daytime high around 86 degrees. The clouds that we pick up during the day today will linger into the evening leaving the overnight low around 63 degrees.
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Gift Premium Subscription To dusty1025
Join Date:11-22-2010
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Posted in thread: Sanke keg spear on 09-24-2015 at 12:14 AM
Pm sent. Thank you.
Posted in thread: Sanke keg spear on 09-22-2015 at 01:26 PM
I'm east of Pittsburgh. Near Johnstown. Both of you guys are 4+ hours east. PM me with a price
if you'd be interested in mailing one.
Posted in thread: Sanke keg spear on 09-22-2015 at 01:04 AM
Most of the ones I've seen here have been given away for the cost of shipping, but I'd like to
have one and I can't find one so I do expect to pay for it. Let me know what you'd be willing
to sell it ...
Posted in thread: Sanke keg spear on 09-21-2015 at 12:48 PM
Anybody out there have a D coupler sanke keg spear left over from making a Keggle? I'm making a
pump to clean my draft system and I can't find one anywhere local. It doesn't need to be full
length. Th...
Posted in thread: tap system emergency on 02-13-2014 at 08:36 PM
Ok great thanks. How long do you think it'll take to carb up. Without shaking the kegs?
Posted in thread: tap system emergency on 02-13-2014 at 01:35 AM
I was away for about two weeks, went to pour a beer and my co2 tank is EMPTY. I mean dead
empty. Wouldn't pour more than a few drops. I have a 1/4 keg of Miller lite, 1/6 bbl of
sangria, and 1/6 bbl o...
Posted in thread: Easy Stove-Top Pasteurizing - With Pics on 12-29-2013 at 01:39 AM
Remember, there is no need to submerge the bottles. Steam works just as well. I steam
pasteurized 32oz cider bottles on a rack in a converted keg. Raise the chamber temp to 165
degrees and hold for 8 ...
Posted in thread: s-04 flocculation reversal??? on 12-28-2013 at 12:55 PM
I cold crashed a 5gal batch of hard cider IG 1.080 fermentation stopped at 1.030, I was
shooting for 1.020, but it was store bought juice and I didn't aerate it properly prior to
pitching.My question ...
Posted in thread: How to make super sweet cider/blending on 07-11-2011 at 09:20 AM
i pasteurize a around 1.020 in 32oz bottles after i back-sweeten with apple juice concentrate.
each can of concentrate adds about 0.004 gravity points. i add 2 cans to a 5 gallon batch for a
finished ...
Posted in thread: Skeeter Pee on 07-08-2011 at 09:18 PM
My regular pee is very pale.thats great. . . means you're well hydrated


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Mysterious HTC tablet leaked complete with iMac style design
Pictures of an unannounced HTC tablet have turned up in the internet, suggesting the company could be about to re-enter the tablet market with a new device based on the design ethos of its One series announced in February this year.
The images, which look to have been pulled from a promo video, have been posted on an unused Twitter account before being picked up by phone blog pocketnow.com.
There are no details or specs to accompany the images but, judging from the pictures, the device will run Android with a few tweaks.
What is different from your standard-looking tablet however is the design of the tablet itself.
If the pictures are real, the tablet has a lopsided design that reminds us of an Apple iMac, with a camera at the bottom of the tablet's display when held in landscape orientation. When in portrait the extra space seems to be for gripping the device without worrying about interfering with the screen.
From the pictures, the new tablet looks to be a 10-inch tablet rather than 7-inches as seen on HTC's first tablet, the HTC Flyer. Likewise, there is no reference in the images to the inclusion of a stylus as found in the Flyer.
As to when HTC could announce the device, or in fact if the images are real, is still anyone's guess.
We will keep you posted.
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