text:
Adrienne Bailon[Photo Credit: Splash News]
Dwyane Wade[Photo Credit: Splash News]
Jenna Malone[Photo Credit: Getty Images]
Julianne Moore[Photo Credit: Getty Images]
Regina King[Photo Credit: Getty Images]
Adrien Brody[Photo Credit: Getty Images]
Alfre Woodard[Photo Credit: Getty Images]
John Waters[Photo Credit: Splash News]
Saorise Ronan[Photo Credit: Getty Images]
Rita Ora[Photo Credit: Splash News]
With only a few days left before this year's Academy Awards, we're hoping that what we saw on red carpets this week actually isn't a harbinger of things to come. There were definitely some questionable looks in the celebrity world as of late, and we'd like to think that folks are either testing the waters or just saving their best looks for Oscar night. Whatever the case may be, let's make sure we start bringing our A-game, shall we?
Julianne Moore and Alfre Woodard, two of the best actresses the world has ever known, disappointed us by cobbling together random pieces of fabric to create unappealing ensembles. Adrien Brody and Jenna Malone tried daring looks, but fell quite a few notches short of chic. We also caught candid shots of stars like Dwyane Wade just sporting their bad choices in front of the masses.
So who do you think got a citation from the fashion police this week? Vote for your favorite fashion fail below?
Who Was The Week's Worst Dressed Celebrity?
[Photo Credit: Getty Images/Splash News]


text:
This review is from: SYBA CL-ADA31019 Mini-DVI to VGA Adapter
I can not list any pros for this adapter as it did not function with my computer.
This adapter did not work with my Macbook.
My Macbook
Mac OS X version 10.5.8
Model identifier MacBook 3.1
Newegg readily accepted the return. Great service.
Other Thoughts:
It would be helpful if more detailed information was available as to what MacBooks this cable is intended for.
Did you find this review helpful? Yes / No Thanks for the valuable feedback you provided!

subset: commoncrawl


text:
For those who don't need higher education with their beverages, move over Dr Pepper… it's time to spend the day with Mr. Cola!
This is another vintage brand revived by the folks at Orca Beverage Soda Works of Mukilteo, WA. Originally created in 1949, Orca snapped up the trademark in November 2011. They are offering this product in a 12 oz clear longneck bottle, complete with a vintage-styled label design, which curiously places the phrase "Mr." in quotes. What's that about?
This product was originally created to compete with other colas at the time, being given the name, the "Aristocrat of Colas." With cane sugar and caffeine, I guess that works quite well!
Popping the bottlecap off, you are greeted with a cola scent, more on par with RC or Coca-Cola than Pepsi. It's less sweet. The flavor is a solid cola experience with a very clean aftertaste. It reminded me a bit of other non-mainstream colas, such as Jarritos Mexican Cola , Trader Joe's Vintage Cola, or Jones Pure Cane Cola Soda. While the scent doesn't hint at the sweetness, the flavor is definitely sweet. It's a standard cola and not distinctively memorable, however.
Mr. Cola has a nice vintage package and presentation. The cola flavor is of good quality and provides a nice change of pace from established brands. Still, it's not a unique experience that you'd want to revisit repeatedly.
Mr. Cola
Carbonated water, cane sugar, caramel color, phosphoric acid, natural flavors, caffeine
A 12 oz bottle contains 150 calories, 85 mg sodium, and 39 g carbs (39 g sugars)


text:
You came into my desperate life,
I made you my own, made you my wife.
Now you leave me out in the cold,
What, did our love get too old?
Didn't I hold you in my arms when you needed me?
Didn't I love you without restraints blindly?
It wasn't enought to sacrifice myself for you,
Now you show this side of you I never knew.
But life goes on and so will I,
Sure there are times when I get a tear or two in my eye,
But in the end I can do nothing but continue to fly.
Yet, I get the feeling that these tears will never dry.
© Copyright 2017 Mezquiteno. All rights reserved.
Status: Finished
Genre: Poetry
Book / Poetry
Short Story / Other
Short Story / Other
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text:
Above and beyond… Stuart, Debbie and the team really take service and commitment to the next level.
- Diane Stanbra, Picnic Box
Magnum Custom Trailers stated what they could achieve and stuck by it, exceeding the expected.
- S.G. (Steve) Day, Managing Director at Pace Engineering Ltd
Thanks Debbie and Stu, great people providing great products and excellent service.
- Craig Barnes, Crazy Mixed Up Ice Cream
The standard of workmanship, the attention to detail, the sourcing of competitively priced components and the sheer professionalism of the entire process have been brilliant.
- Nonie and George Connor, Waiheke Island


text:
Skip to comments.The Zero Hour Scenario (Default On Precious Metals)
Posted on 03/10/2013 9:40:58 AM PDT by blam
click here to read article
No economist am I but previously in investing these types of articles are published just as a major broker is getting a huge sell order and needs to place it.
"Every year, major banks and brokerage houses provide their four-year forecasts for the gold price. The following chart documents the average price projection of 25 top analysts over the past seven years, many of whom specialize in the resource industry. I might suggest pushing away from your desk so that when your jaw drops it doesnt hit the keyboard.
If I were a buyer of Gold, I'd insist on NOTHING but physical possession of it. Buying the so called 'paper' would be unthinkable to me. If security of my physical possession is a concern, that's what safes are for. One can always rent a 'deposit box' at the bank as well, but I'd prefer a nice big(at least 1,000lbs) fire-rated safe, bolted to my basement floor to store things in.
That's why you want to own mining stocks. You can get dividends now, and will be leveraged when TSHTF.
Don't go crazy on them, no more than 3% of your portfolio in any one stock or 10 to 15 % in the sector depending on your risk tolerance. The sector ETF is GDX, which pays about a 1.24% dividend, and it's currently a falling knife, so this not for the faint of heart. Use stop losses or options so you don't get sliced up too badly.
Investing is about patience and judgment, because the market will always be one step ahead of you.
(It has nothing to do with the Italian automobile manufacturer, FIAT, which many say due to its poor workmanship is an acronym for, Fix It Again, Tony .)
and when the government then demands that you turn in all your gold to them and makes it illegal to own gold (this was done before)... what are you going to do then?
face it... when the end comes... there is no way to escape and no right answer.
I would say that the Germans trying to get their gold back from New York have provoked a de facto default. The most obvious explanation as to why would it take seven (?) years to move many things each the size of a brick from point A to point B is that they just don't have them right now. Any security concerns offered as reasons not to move it in a timely matter, despite the matter of that diamond heist in Brussels in February, are simply red herrings.
And there is precedent. When nickel officially defaulted in 2006, the criminals at COMEX (aka CRIMEX) simply said, eh, ok, sellers pay buyers one percent per day until they can deliver. You can bet that gold would be going up more than one percent per day in that scenario, and CRIMEX wins again.
"...and when the government then demands that you turn in all your gold to them and makes it illegal to own gold (this was done before)...what are you going to do then?"
Shoot first, ask questions later. :)
P.S. A TEXAN is asking this and a YANKEE has to answer? LOL! ;)
I will relate this story again for the benefit of my FRiends...
A friend of mine took possession of physical PMs...a lot of PMs.
One fine morning her husband walked into the garage and was met by a man in a ski mask with a pistol.
If her husband had not been an incredibly brave and strong 70 year old man, they would both have been dead after the obligatory torture session.
As it turned out, both hubbie and she were badly bloodied but alive as the robber escaped dropping his mask and zip ties as he fled.
The robber looked like an absolutely normal white guy like you would see shopping at Wallymart. No tats, piercings, etc.
The robber was never caught.
My friend had not told anyone that she had PMs. Who knew? The coin shop? The UPS driver?
Remember OPSEC at all times. Do not keep PMs in your gunsafe, home, or other obvious place.
Bank safes aren't that reliable. If the gov't is in desperate need of gold, they can make the banks deny access or inspection to safe deposit boxes belonging to "the subjects".
Yes, the Germany deal is what I was thinking about. Looked like a default to me.
And you can't trust bank safety deposit boxes, either, as any run on the bank will also block access to your box.
So what is the answer? Get creative with your home remodeling.
and use a P.O. box. You should not have valuable items mailed to your home address.
Not investment advice, but the stop-loss order often goes under everyone's radar screen. You can't use them with Mutual Funds, they are not available with that instrument.
With ETF's trading "Intra-Day" if the SDHTF and the markets have a huge correction in one day ( a la Sept 08') and you hit you exit number, you are in Schaffer City....
why don't you define it for us; it would make your story so much more interesting.
I'm of the believe that probably 75% of 'OPSEC' is people keeping their damn mouths shut, and preventing outside knowledge of what you have.
Why would anyone pay the spot price for 1oz of pure gold (99.99%) for a 1oz coin coin that is only 91.6% gold?
Bring back US manufacturing, and none of this discussion would be necessary.
Stop exporting US jobs.
Thanks for your astute answer to my question.
You are welcome.
For 30 years we have been sending US jobs abroad. We have switched places with China.
Except China owns all the manufacturing we are sending there.
We are creating history's largest problem, right now.
If you wish to invest in gold stocks, that's fine. Although I own PMs and have invested in and traded PM stocks in the past, I do not like them now. That doesn't mean I may return to them in future...but I think investing in them is kind of wrong now. That's just my opinion.
But GDX is IMHO absolute poison. GDX is a Goldman Sachs fund and they use it to short mining stocks by shorting the whole sector. It is poorly diversified, about 12% ABX and about 12% GG, the rest little snippets of about 1% or less of many other companies. I heartily unrecommend it.
Thank you. I was unaware that the coin weighed more than 1 troy oz.
The South African Krugerrand is 1.1 ounces, 1.0 ounces is gold and the other .1 ounce is copper. Pure gold is to soft to make into coins without an alloy. The copper gives the Kruggerrand it's distinctive 'red' hue. I bought many of these in the early 90's for $382.00 each.
I wish I had kept more of them than I did.
I lost mine when my dumb neighbor stood up and my bass boat tipped over.
Goldbug ping.
Looks like some folks want more of that gold money in stocks and bonds for now.
PM = precious metals, not just gold and silver but also palladium and platinum
You have to buy them from somebody on the USG's list of dealers, who are themselves charged three or four percent to start with. You can't buy them direct from the mint or the treasury.
Thanks, but not looking to. I'm in Philharmonics.
My Philharmonics say 99.99% or am I missing something?
What part was silly?
My friend did keep her mouth shut.
She told no one. I am her friend and business partner and I had no idea that she had physical PMs until after the incident.
She did everything right and still almost got murdered. Her only screwup was not being armed 24X7. She and hubby were unarmed when the surprise stickup went down.
My point is that when you order PMs from another state, someone at UPS/Fedex knows that a package left a PM seller and went to a particular address. It could be a driver, clerk, manager, or whatever.
Or it could be an employee of the bullion seller who sells the info on the black market for money. It could have been a bank employee who knows what credit cards numbers and addresses are tied to bullion sales.
So how do you practice OPSEC?
PM = precious metal, i.e., gold silver platinum
Who Owns The Federal Reserve?
The Fed is privately owned. Its shareholders are private banks
One can set up a "Precious Metals IRA" ...
PMs placed in IRAs must be 99.9% (or better) purity.
American Eagles are legit for a PM IRA.
The old silver coins (pre-1964) were 91% purity, so old silver coins CAN'T be used in PM IRAs.
IIRC - there are also old US gold coins that, like South African Krugerands, are around 91% purity - and therefore not eligible for inclusion in a PM IRA.
Well, Plan B is to wait for the government to come to their senses, then...WAIT! What am I talking about? LOL!
I'll liquidate before that happens, and turn those hard assets into other hard assets: land, a paid off farm and more ammo, etc.
I watch this stuff EVERY day - they're not going to catch me unawares.
And I have an excellent broker that I deal with, face to face. He'll call me if he sees anything hinky on the horizon as well. :)
Are you new to this? A one ounce gold coin contains one ounce of gold. If they are soft pure 24C gold, the coin weighs one ounce. (Troy, of course, we are talking about.)
If they are harder 22C gold, they still contain one ounce of gold, plus copper, silver and other metals to make them harder and more durable. In that cases, the coins weigh about 1.1 ounce, with 1.0 ounces of it being pure gold.
Really, you didn't know this?
Mine fell out of my canoe with my guns.
Some coins are "soft" pure gold. Canadian Maple Leafs, Chinese Pandas, and some others. Normally they are each kept in a little plastic case, except for inspections at sale. They can ding each other up if stored against one another.
portability and recognized content and a market value based on those factors
I'm not paying anyone for "gold bullion" from some 3rd world country
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Mental as AnythingWhile the women are shopping for supplies on an asteroid outpost, the men of Moya's crew visit a man named Katoya who can teach them forms of mental conditioning. Scorpius believes it will help Crichton to resist the Scarran heat probe should he ever encounter it, but Crichton is more concerned with finding out if Katoya knows anything about the creature that attacked his family. During the training, D'Argo discovers that someone else has arrived to learn from Katoya: Macton, the brother and murderer of Lo'Laan, D'Argo's wife. D'Argo is determined to take revenge, but Macton throws doubt onto D'Argo's strongest convictions about what happened on the night Lo'Laan died. As D'Argo's Luxan hyper-rage and Macton's love for his sister are examined, the truth about what happened comes to light: when Macton threatened to get rid of D'Argo, Lo'Laan tried to stab her brother to save her husband. Macton instinctually defended himself and killed Lo'Laan, then beat her corpse to make it look like D'Argo did it in a fit of Luxan hyper-rage. Macton is left in a coma, forced to relive the memories of killing his sister, while the men of Moya leave. Crichton and Scorpius discover that the creature they encountered on Earth was most likely reporting to Grayza, and the Peacekeepers now know the location of Earth.
Tropes present in this episode include:
- And I Must Scream: Macton's plan is to trap D'Argo in an endless nightmare where he relives his tortured memories. D'Argo breaks free and traps Macton in that instead.
- Continuity Nod: Crichton is on this trip because he wants to know about the creature that murdered his friends and attacked his family.
- Cruel Mercy:
Rygel: If you were fine, you'd have killed Macton instead of leaving him there.
D'Argo: He's trapped in a coma with his own nightmares. Killing him would have been merciful. I'm not that enlightened.
- Flashback: Many throughout the episode showing D'Argo's marriage.
- Genre Savvy: How D'Argo ultimately realizes Macton is lying about Lo'Laan being Driven to Suicide.
"I loved my wife, but you wouldn't know that. You didn't know Lo'Laan; I did. She could have left me for my failings. Maybe she should have, but I know this: she would never have left her son without a mother."
- Noodle Incident: Following up on an old plot-point, in-between Seasons 3 and 4, D'Argo tracked down Macton, but he hesitated from killing him.
D'Argo: Part of me knew that wouldn't bring Lo'Laan back. And another part couldn't resist letting him know that I knew exactly where he was.
- Retcon: When Macton and Lo'Laan were first mentioned, it was established that Macton murdered her in cold blood over her marriage to D'Argo, which was even corroborated by Crais. This episode reveals that Lo'Laan attacked her brother with a knife to stop him from falsely (maybe) reporting D'Argo for abuse. Macton's Peacekeeper training kicked in, and he killed her in self-defense and entirely on reflex. His only actual crime in her death was desecrating her corpse and framing D'Argo for the murder. It didn't make him any less of a douche, but it does make him somewhat more sympathetic .
- Additionally, it's suggested that D'Argo may have killed Lo'Lann in a fit of hyper-rage. While D'Argo's struggles with his anger have long been established, the episode attempts to claim he's always had doubts about whether or not he did kill Lo'Lann. Prior episodes never once had him express doubt about it, even having Crais admit he knew D'Argo was wrongfully imprisoned.
- Shout-Out: Crichton whistles the "Colonel Bogey March" at various points during the episode.
- What Happened to the Mouse?: While mentioned in the present, Jothee is never shown during the flashbacks.


text:
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10.5 Tog Freshwash Hollowfibre Duvet - Single
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text:
Chick wrote:
You are doing good chick. Keep it up. My diversion on world agriculture
was, if you read it, intended to show that the practices of most hosta
gardeners, certainly including myself, if transposed to everybody else
in the world doing what they also thought would do no harm, wouold in
the end destroy the soil to the poing we couldn't feed ourselves. Take
comfort in the knowledge that this is a long way in the future!
Organic gardening is
> a fine way to grow plants, but it is not the only way. People who practice it
> tend to think that the rest of us are ruining the world. My point, which was
> ignored, is that before you tell me that I'm doing something bad, you should be
> able to tell me what harm I am doing if I don't follow your rules. I never saw
> that happen.
> Chick
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text:
BERLIN — Here is a quick run-through of what you missed if you didn't attend the Internationalen
Funkausstellung (IFA) trade show, held here earlier this month — 3D TVs and related technology from major
brands, tablet PCs from Samsung and Toshiba, and even headphones inspired by music
legend Quincy Jones that will be sold by Harman.
See www.twice.com/article/456787-Sept13.php for more sights from IFA.
Want to read more stories like this?
Get our Free Newsletter Here!
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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Native Policeman (JIRA)" <j...@apache.org>
|[jira] Commented: (LUCENE-2791) WindowsDirectory
|Fri, 03 Dec 2010 11:55:11 GMT
[ https://issues.apache.org/jira/browse/LUCENE-2791?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=12966497#action_12966497 ] Native Policeman commented on LUCENE-2791: ------------------------------------------ bq. So bottom line: I disagree with you on everything you said. This was not against you, but I am hacking native Windows since Win32 was started :-) bq. Yes I do use it, do you understand C ? I kill you the next time we meet. I am hacking C longer than Java. This was not about C it was about the MSDN docs telling something different. See my last comment above. Thats all. Why are you so aggresive? {quote} bq. Exception handling: in native read, you call throwIOException, when ReadFile() returns false. But 2 lines later you still call the method to copy the local buffer to the java byte array. JNI docs say, that after an Exception is in the thread's local exception, you should not call any JNI methods anymore (expect some allowed ones). Also the copy operation is not really needed. I don't think you know what you are talking about! {quote} Sorry we seem to have a misunderstanding. I was *not* talking about the internal copy the JVM does. I was talking about the fact, that you should not call JNI functions anymore when you set the thread's exception status and exit the function as soon as possible. You set this status after the failed ReadFile with throwIOEx(). After that its no longer needed to copy the buffer[] to the java byte array and its risky to do it because I am not sure if this env->SetByteArrayRegion() is safe to be called after exception status is set - that all I wanted to say. I would change tha code to: {code} if (ReadFile((HANDLE) fd, &buffer, length, &numRead, &io)) { env->SetByteArrayRegion(bytes, offset, numRead, (const jbyte *) buffer); } else { throwIOException(env, GetLastError()); numRead = -1; } {code} Please note env->throwNew() always returns, it simply sets the thread's exception status, so the JVM thorws the Java Exceüption passed in after the native method returns to Java bytecode again. Thanks, Native Policeman > WindowsDirectory > ---------------- > > Key: LUCENE-2791 > URL: https://issues.apache.org/jira/browse/LUCENE-2791 > Project: Lucene - Java > Issue Type: New Feature > Components: Store > Reporter: Robert Muir > Attachments: LUCENE-2791.patch, LUCENE-2791.patch, WindowsDirectory.dll, WindowsDirectory_amd64.dll > > > We can use Windows' overlapped IO to do pread() and avoid the performance problems of SimpleFS/NIOFSDir. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online. --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: firstname.lastname@example.com
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text:
Version 17.0/16.5 (three versions - Build 161221 161203 and 161012) of ExTiX 64 bit are based on Debian/Ubuntu. The original system includes the Desktop Environment Unity (Ubuntu). In ExTiX I have removed Unity and installed LXQt 0.10.0 respectively KDE 4.16 together with KDE Frameworks 5.26 instead.
PROGRAM content etc (all versions)
Among many other programs LibreOffice, Thunderbird, GParted, Google Chrome, Brasero, SMPlayer, Gimp, Flash and win32 codecs. In addition Java and all necessary additions in order to install programs from source. Google Chrome for Netflix and BlueGriffon as Web Editor.
The password for root is root. No password is needed for the ordinary user extix.
4.9.0-11-exton, 4.8.0-26-exton respectively 4.8.0-21-exton.
Refracta tools in ExTiX 17.0 KDE - Create your own live installable Ubuntu system!
Build 161203 is only for Intel Compute Sticks - http://www.intel.se/content/www/se/sv/compute-stick/intel-compute-stick.html
ExTiX - The Ultimate Linux System Web Site
- Build 161203 is only for Intel Compute Sticks
- LXQt 0.10.0 instead of Unity in Build 161012
- Runs from RAM - Copy to RAM - Boot alternative 3
- Based on Ubuntu 16.10 - 64 bit - and Debian 8.6/9
- KDE Frameworks 5.26 and KDE 4.16 instead of Unity in build 161221
- USB installation - Persistent - done in two ways
- All common KDE packages in build 161221
- Kernel 4.8.0-21-exton - Kernel.org's 4.8 - in the LXQt version
- Kernel headers in all versions
- Nvidia's proprietary driver 370.28 is installed in the LXQt version
- GParted
- All necessary additions in order to install programs from source (in both versions of ExTiX)
- Live system - run it from DVD or USB
- Adobe flash
- LibreOffice in both versions of ExTiX. The whole suite in the KDE version
- Debian "Jessie" (Debian 8.6)
- ISO-hybrid - just copy the ISO file to a USB stick and run it!
- Synaptic Package Manager
- BlueGriffon Web Editor in the LXQt version. ("Dreamweaver" for Linux)
- Google Chrome - for Netflix - in both versions of ExTiX
- Samba for reaching your Windows shares
- 64 bit - both versions of ExTiX
- Java
- Kernel 4.9.0-11-exton - Kernel.org's 4.9 - in the KDE version
- Build 161203 is only for Intel Compute Sticks
- Kernel 4.8.0-26-exton-IntelAtom in Build 161203
- LXQt 0.10.0 instead of Unity in Build 161203
- All multimedia codecs are installed
- Refracta tools are installed in ExTiX KDE 17.0 161221
- Create you own live installable Ubuntu system with Refracta tools
User Ratings
User Reviews
I had lots of bugs with Ubuntu 12.04 64bit but I liked the screenshots on distrowatch. Hence I gave it a go. Install was only possible via live - gnome session and my username was not taken. But hey all the rest is perfect. It looks good and I haven't found one single bug so far!
Very nice (clean) linux desktop. Runs very well from DVD (much better then many I have tried before). Harddisk instakllation is also easy. No distro if you want 20 programs to do the same thing. Comes standard with all media support (file types) to view YouTube etc. out of the box (fresh install)


text:
Sick Of It All - Just Look Around (Music CD)
Release Date: 22 March 2010
Artist: Sick Of It All
£5.89 includes FREE UK Postage (other delivery options available)
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UK - Shipping Included
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Falkland Islands
Release Date: 22 March 2010
Artist: Sick Of It All
1. We Want The Truth
2. Locomotive
3. The Pain Strikes
4. Shut Me Out
5. What's Goin' On
6. Never Measure Up
7. Just Look Around
8. Violent Generation
9. The Shield
10. Now It's Gone
11. We Stand Alone
12. Will We Survive
13. Indust
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Catalogue No: 9962232


text:
BAGHDAD (Reuters) – An Iraqi court on Sunday sentenced fugitive Vice President Tareq al-Hashemi to death by hanging after a trial on charges he ran death squads, Abdul-Sattar al-Birqdar, a spokesman for the judiciary council said.
Comment count on this article reflects comments made on Breitbart.com and Facebook. Visit Breitbart's Facebook Page.


text:
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So here it is finally. The reaction video for the Lamborghini LP700-4 Aventador. Check it out.... some very funny moments and lots of love--and as you can expect, some hate. Always have to take it in stride. Feel free to share your comments. Chase ride is a BMW Z4M with custom Exhaust and cosmetic mods.... sweet ride!
Lamborghini LP560-4 Spyder "chases" LP700-4 Aventador
During recent test drive of the Aventador, I created a "chase" scene which by buddy Tim was test driving the Aventador. Seeing the Aventador upload from the outside is just amazing.... all the lines, all the flowing and active surfaces just make you wonder what other surprise is about to hit. This is especially try to the untrained observer. It obviously makes people do crazy things... check out the Toyota Corolla in the video. Some clips have pretty bad wind noise... sorry, tried to repair but it is what it is :-( So, Aventador (big bro) or LP560 (L'il bro). Which do you prefer? HONORS: 1.24.2011 #70 -- Top Favorited (Today) -- Autos & Vehicles 10.25.2011 #47 -- Top Favorited (Today) -- Autos & Vehicles #81 -- Top Rated (Today) -- Autos & Vehicles
Lamborghini Centenario LP 770-4: First Impressions: HOLY COW!!! 😱😱
First unveiling of the new Lamborghini Centenario LP 770-4, limited to 40 cars. 20 coupes & 20 roadsters. This car is powered by a 6.5L V12 that does 0-100 km/h in 2,8 seconds, 0-300 km/h in 23,5 seconds with a top speed of over 350 km/h. The Centenario weighs 1,520 kilos. I am floored by this car. SPEECHLESS!


text:
The Essential Writings of Jonathan Swift
Authoritative Texts, Contexts, Criticism
By (author) Jonathan Swift
Edited by Claude Rawson Ian Higgins
Format: Paperback
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Essential Writings of Jonathan Swift by Jonathan Swift
Book Description"Contexts" features a generous selection of contemporary materials, among them Swift's letters, autobiographical documents, and personal writings. "Criticism" provides readers with a wide chronological and thematic range of scholarly interpretations, divided into two sections. The first, "1745-1940," includes assessments by Henry Fielding, Samuel Johnson, Samuel Taylor Coleridge, William Makepeace Thackeray, D. H. Lawrence, W. B. Yeats, F. R. Leavis, and Andre Breton, among others. The second, "After 1940," is by subject and collects critical discussions of A Tale of the Tub, the poems, the English and Irish politics, and Gulliver's Travels, by Hugh Kenner, Marcus Walsh, Irvin Ehrenpreis, Penelope Wilson, Derek Mahon, S. J. Connolly, George Orwell, R. S. Crane, Jenny Mezciems, Ian Higgins, and Claude Rawson. A Chronology and Selected Bibliography are also included.
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Book DetailsISBN: 9780393930658
(236mm x 145mm x 30mm)
Pages: 944
Imprint: WW Norton & Co
Publisher: WW Norton & Co
Publish Date: 23-Oct-2009
Country of Publication: United States
Books By Author Jonathan Swift
Gulliver's Travels, Paperback / softback (May 2017)
Originally published: Minneapolis, Minn.: Stone Arch Books, 2008.
Understanding Business in the Global Economy, Paperback / softback (November 2016)
Focussing on the way in which relationships at various levels underpin international business activities this book presents a contemporary and realistic analysis of International Business in action. The concept of change permeates the text, highlighting the dynamic and often turbulant nature of international business and management.
Gulliver, Hardback (November 2015)» View all books by Jonathan Swift
Lost in a land of small people, Gulliver has to learn their ways and avoid starving! Then he lands in a country of giants. A beautifully illustrated and energetic retelling of one of the world's favourite stories.
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Author Biography - Jonathan Swift
Claude Rawson is Maynard Mack Professor of English at Yale University. He is the author of God, Gulliver, and Genocide: Barbarism and the European Imagination: 1492-1945, English Satire and the Satire Tradition, and Satire and Sentiment, 1660-1830: Stress Points in the English Augustan Tradition. He is General Editor of the Works of Jonathan Swift (Cambridge University Press) and co-editor, with Ian Higgins, of the Oxford World Classics edition of Gulliver's Travels. Ian Higgins is the author of Swift's Politics: A Study in Disaffection (1994) and Jonathan Swift (2004), and is an editor (with Claude Rawson) of Gulliver's Travels (2005). He is a Reader in English at the Australian National University in Canberra, Australia, where he teaches courses on early modern and eighteenth-century literature and on British imperial fiction.
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LCD is a technology for displaying images. LCD screens are flat, thin and have a reasonably high resolution and are therefore much used as computer monitor, but are also very suitable for use in a television!LCD TVs
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Long product name Sony 32" V-series BRAVIA LCD TV 32" HD ready:
The short editorial description of Sony 32" V-series BRAVIA LCD TV 32" HD ready81.28 cm (32 ") V-series BRAVIA LCD TV HD Ready
Marketing text Sony 32" V-series BRAVIA LCD TV 32" HD ready:
The official marketing text of Sony 32" V-series BRAVIA LCD TV 32" HD ready as supplied by the manufacturer-32" V-series BRAVIA LCD TV;
-HD Ready;
-Integrated Digital TV Tuner (also receives analogue);
-High Performance LCD panel;
-WCG-CCFL backlight and Colour Filter Side;
-Fast Response Time 8ms;
-Wide Viewing Angle 178 degrees;
-On screen contrast 1700:1;
-Dynamic Contrast 7000:1;
-SRS TruSurround XT for enhanced surrounding effect;
-PIP Freeze to Pause Important Scenes on the Spot;
-Swivel to Adjust Display to the Best Viewing Position;
-High Definition Multimedia Interface (HDMI) x2;
-PC Input for use as a PC monitor;
-Non-Reflective coating on TV frames;
Short summary description Sony 32" V-series BRAVIA LCD TV 32" HD ready:
This short summary of the Sony 32" V-series BRAVIA LCD TV 32" HD ready data-sheet is auto-generated and uses the product title and the first six key specs.Sony 32" V-series BRAVIA LCD TV, HD, 16:9, Digital, 1366 x 768 pixels, NICAM, TruSurround XT, Sleep/On
Long summary description Sony 32" V-series BRAVIA LCD TV 32" HD ready:
This is an auto-generated long summary of Sony 32" V-series BRAVIA LCD TV 32" HD ready based on the first three specs of the first five spec groups.Sony 32" V-series BRAVIA LCD TV. HD type: HD, Display resolution: 1366 x 768 pixels, Aspect ratio: 16:9. Audio system: NICAM, TruSurround XT. Programmable timers: Sleep/On
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Display diagonal*
Size of the display for this product, measured diagonally, usually in inches.
81.3 cm (32")
Display brightness*
Brightness is the amount of radiating light emitted from the screen. The brightness rating is measured in candellas per square meter, commonly known as 'nits'.
450 cd/m²
HD type*
Type of supported High Definition (e.g. Full HD, 4K Ultra HD).
Display resolution*
The number of distinct pixels in each dimension that can be displayed. It is usually quoted as width × height, with the units in pixels: for example, "1024 × 768" means the width is 1024 pixels and the height is 768 pixels. The higher the number of pixels, the sharper the image.
1366 x 768 pixels
Aspect ratio*
The aspect ratio is the ratio of the width of a shape to its height. For example, 4:3 is common for standard displays and 16:9 is the ratio for Widescreen TV.
Viewing angle, vertical*
Maximum vertical angle at which a display can be viewed with acceptable visual performance.
Viewing angle, horizontal*
Maximum horizontal angle at which a display can be viewed with acceptable visual performance.
Response time*
The response time is the time difference between the moment that a source (for example a video card) sends a signal and that equipment (for example a monitor) receives or display the signal. (Used abbreviations: R/F = Rise and Fall.)
8 ms
Comb filter
Viewable size diagonal
82 cm
Audio system
System used to play music or speech.
NICAM, TruSurround XT
Ports & interfaces
HDMI ports quantity*
The number of sockets (ports) for HDMI connections. HDMI (High-Definition Multimedia Interface) is a compact audio/video interface for transferring uncompressed video data and compressed/uncompressed digital audio data from a HDMI-compliant device ("the source device") to a compatible computer monitor, video projector, digital television, or digital audio device. HDMI is a digital replacement for existing analog video standards.
PC in (D-Sub)*
The socket (port) to receive input from a PC via a D-sub, which is a connector with a characteristic D-shaped metal shield.
Component video (YPbPr/YCbCr) in*
The number of sockets (ports) for RF (radio frequency) connections into the product.
Composite video in*
The socket (port) for the composite video input (white cable).
S-Video inputs quantity*
The number of ports (input sockets) for S-Video, which is a signalling standard for standard definition video, typically 480i or 576i.
RF ports quantity*
The number of sockets (ports) for RF (radio frequency) connections.
Ports & interfaces
SCART ports quantity *
The number of sockets (ports) for SCART connections.
Audio (L,R) in *
The two sockets (ports) for receiving left audio signal (white cable) and right audio signal (red cable).
Audio (L,R) out *
The two sockets (ports) for transmitting left audio signal (white cable) and right audio signal (red cable).
Headphone outputs *
Number of sockets /ports where headphones are connected.
700 pages
Management features
Programmable timers
Sleep/On min
On Screen Display (OSD)
Power consumption (standby) *
The amount of electricity that is consumed when the product is on standby.
Power consumption (typical) *
Amount of power consumed by this model, often expressed in watts (W). Typical values that manufacturers give are power consumption when off, standby/suspended mode, typical use, maximum usage.
Weight & dimensions
Width *
The measurement or extent of something from side to side.
792 mm
Depth *
The distance from the front to the back of something.
99 mm
Height *
The measurement of the product from head to foot or from base to top.
546 mm
Width (with stand)
792 mm
Depth (with stand)
219 mm
Height (with stand)
593 mm
Weight with stand
17 kg


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Cleveland anyone?
Anyone here from the Cleveland, Ohio area and surrounding region?
My Tanks:
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(2) 29 Gallons -Livebearers - Saltwater (Live rock)
(2) 10 Gallons -Dwarf Puffers
(1) 2 Gallon- Baby tank
(3) 1 Gallons- Baby Livebearers
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Is Healthgenie incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog INDIA provides information regarding Healthgenie. Healthgenie provides Skin Care services. Contact them on 011 48323232 or by visiting them on their website http://www.healthgenie.in.
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text: Contacts+ Updates, Adds Quick Action Buttons and Customization ToolsAlan Henry12/24/13 5:30amFiled to: downloadsandroidandroid downloadsaddress bookcontactsorganizationupdates226EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Android: Contacts+, our favorite address book for Android, picked up an update today that gives you more control over how you browse your contacts, and offers quick-action buttons to let you call, email, or text them right from your contacts list. The updated version definitely features a fresh coat of paint, but there's a bit more going on under the hood. You can customize the contacts list as well as the portraits for each person in your contacts (choose from round or square portrait photos), and long-pressing on any contact will bring up quick action buttons that let you immediately call, text, or email them using your preferred apps. The dialer has been updated to support numerical and text search, and the rest of the app has picked up a performance boost and a general overhaul to fit in more smoothly with Android's own UI. Hit the link below to grab the update. Advertisement Advertisement Contacts+ (Free) | Google PlayReply22 repliesLeave a reply


text:
35-44 year old woman treated with Breast Lift with Implants
Was this photo helpful? {{ voteCount + ' other' + (voteCountOthers == 1 ? '' : 's') }} found this helpful
43 year old female who had 405cc implants placed with a breast lift.
By uploading this photo, Keith Hodge, MD has agreed with RealSelf.com policy that they've secured proper patient consent.


text:
Bitter little butterlifes
Lucky in the locks
Titter-totter tatter lies
Running past the rocks
Drinking dipper-dupper drinks
Falling from the docks
Slipper-supper misty thinks
Running past the rocks
Gungy-gungy gupper swamps
Seathing shallow, birds of flock
Metre spent in father chomps
Running past the rocks
Walling whimpers, falling fog
skimming through the box
Selfless lizard, meanful dog
Running past the rocks
Losing edge, the resltess blade
Cutting the fabric frocks
Dancing naked in the glade
Running past the rocks
Come my friends, I beckon you
To pull up brazen socks
Sleep no more, the night is through
Running -Through! - the rocks.
© Copyright 2017 walkingonfate. All rights reserved.
Status: Finished
Genre: Poetry
you say this isn't good?
I think this is really good, using jargon descriptions to describe how things move and react. And every couple of lines you've got that same "Running past the rocks." Love it, given it an "I Like It" vote.
I loved it! Very good and i absolutely adored the repetition of "Running past the rocks"
Omigod I loved it!!! Its like an echoe poem... I love when poems echoe themselves it makes the message sink into your head in a soothing way...
… I like it. You did a good job on it. You get my vote too.
hey it's very good..! unique writing style, interesting piece. i enjoyed it..!
Nice job on this one. Loved it. Susan :)
nice work.....
Book / Mystery and Crime
Book / Other
Book / Young Adult
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a little late to the game today...left work early....heading to the hospital tonight so my wife can expel a human life out of her vagina. Terrified doesnt begin to describe how i feel right now.
and a fantastic out of focus shot because im a shitty photographer.
Lets do this!
**edit** also this was my 7,000th post! funny timing. hard to believe ive made 7000 dick or fart joakes.
Wow, congrats on the whole "expel out the vagina" thing. That's awesome bro! I've got two boys and two girls. Welcome to the club!!!!!


text:
The littoral is potentially the bloodiest arena in which a modern navy has ever dared to fight, yet we continue to encourage the public expectation of quick victory with few—if any—casualties. Our preoccupation with utopian technical solutions has cultivated a strategic Achilles' heel and left the U.S. Navy poised for defeat in the littorals.
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Today [4]
Lieutenant Commander Adams is executive officer of the USS Honolulu (SSN-718) and a frequent contributor to Proceedings.
None found for this author.


text:
Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behçet's disease
DOI: 10.1186/ar1940
© Delunardo et al.; licensee BioMed Central Ltd. 2006
Received: 24 November 2005
Accepted: 17 March 2006
Published: 12 April 2006
Given the lack of a serological test specific for Behçet's disease, its diagnosis rests upon clinical criteria. The clinical diagnosis is nevertheless difficult because the disease manifestations vary widely, especially at the onset of disease. The aim of this study was to identify molecules specifically recognized by serum autoantibodies in patients with Behçet's disease and to evaluate their diagnostic value. We screened a cDNA library from human microvascular endothelial cells with serum IgG from two patients with Behçet's disease and isolated a reactive clone specific to the carboxy-terminal subunit of Sip1 (Sip1 C-ter). Using ELISA, we measured IgG, IgM and IgA specific to Sip1 C-ter in patients with various autoimmune diseases characterized by the presence of serum anti-endothelial cell antibodies, such as Behçet's disease, systemic lupus erythematosus, systemic sclerosis and various forms of primary vasculitis, as well as in patients with diseases that share clinical features with Behçet's disease, such as inflammatory bowel disease and uveitis. IgM immunoreactivity to Sip1 C-ter was significantly higher in patients with Behçet's disease and in patients with primary vasculitis than in the other groups of patients and healthy subjects tested (P < 10-4 by Mann-Whitney test). ELISA detected IgG specific to Sip1 C-ter in sera from 11/56 (20%) patients with Behçet's disease, IgM in 23/56 (41%) and IgA in 9/54 (17%). No sera from patients with systemic lupus erythematosus, systemic sclerosis, inflammatory bowel disease, uveitis or healthy subjects but 45% of sera from patients with primary vasculitis contained IgM specific to Sip1 C-ter. Serum levels of soluble E-selectin, a marker of endothelial activation and inflammation, correlated with levels of serum IgM anti Sip-1 C-ter in patients with Behçet's disease (r = 0.36, P = 0.023). In conclusion, Sip1 C-ter is a novel autoantigen in Behçet's disease. IgM specific to Sip1 C-ter might be useful in clinical practice as an immunological marker of endothelial dysfunction in vasculitis.
Behçet's disease (BD) is a systemic form of primary vasculitis characterized by recurrent oral and genital ulcers and ocular inflammation and with frequent involvement of the joints, central nervous system and gastrointestinal tract. Its aetiology is unknown. The most favoured pathogenetic mechanism is a genetic susceptibility associated with HLA-B gene polymorphisms. Other evidence indicates a pathogenic role for environmental factors, including infectious agents or autoimmune mechanisms [1]. Supporting an immune origin, serum from patients with BD has been found to contain autoantibodies directed against several antigens, among them autoantibodies against the endothelium [2–10]. Because the low specificity and immunoreactivity of these autoantibodies prevents their use in diagnosis, no serological test specific for BD is yet available. The diagnosis is, therefore, based on clinical criteria. The clinical diagnosis of BD is nevertheless difficult because the signs and symptoms vary widely, especially at the onset of disease.
Our primary aim in this study was to seek and characterize endothelial autoantigens specifically recognized by serum autoantibodies in patients with BD that might be a useful tool in the diagnosis of BD. Because vasculitis in patients with BD mainly involves capillaries and small vessels, and because microvascular endothelial cells differ from vein or artery endothelial cells in phenotype [11, 12], we used a human microvascular endothelial cell (HMVEC) cDNA expression library to identify target antigens. By screening the library with sera from two patients with BD we identified a strongly reactive clone encoding the carboxy-terminal subunit of the splicing factor Sip1 (Sip1 C-ter). We then used ELISA to measure IgG, IgM and IgA specific to Sip1 C-ter in patients with distinct autoimmune diseases characterized by the presence of serum anti-endothelial cell antibodies such as BD, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), various forms of primary vasculitis as well as in patients with diseases that share clinical features with BD, such as inflammatory bowel disease and uveitis. Finally, we evaluated the correlation of serum antibodies specific to Sip1 C-ter with soluble E-selectin, an established marker of endothelial dysfunction.
Materials and methods
Fifty-six unselected out-patients with BD (17 women, 39 men; mean age 37.7 years, range 14 to 58 years; mean disease duration 8.1 years, range 0 to 24 years) attending the Rheumatology Division of the University of Rome "La Sapienza" were enrolled in the study. All patients fulfilled the diagnostic criteria of the International Study Group for BD [13]. Informed consent was obtained from each patient and the local ethics committee approved the study. Glucocorticoids were used in 46.1% of patients with BD, immunosuppressive drugs (cyclosporine A, methotrexate, azathioprine, chlorambucil) in 56.4%, infliximab in 5.1%, interferon α in 5.1%, and 10.2% of the patients with BD were not treated. Patients who had two of the seven findings (oral and genital ulcerations, skin lesions, eye involvement, positive pathergy test, thrombophlebitis and arthritis), or multiple erythema nodosum with severe inflammation and with both elevated erythrocyte sedimentation rate and positive C-reactive protein were assumed to have active disease. According to these criteria, 42% of patients had active disease. The frequency of the HLAB51 allele was 79%. As control groups, we also enrolled 32 consecutive patients with SLE diagnosed in accordance with the American College of Rheumatology revised criteria for the classification of SLE [14], 24 consecutive patients with SSc diagnosed in accordance with the criteria of the American Rheumatism Association [15], 20 patients with primary vasculitis (9 patients with Wegener's granulomatosis, 4 with Churg-Strauss syndrome, 2 with Takayasu's Arteritis, 2 with Horton disease, 2 with microscopic poly-angiitis, 1 with panarteritis nodosa), 33 patients with inflammatory bowel disease (IBD), 17 patients with uveitis (12 with idiopathic diffused uveitis, 5 with idiopathic anterior uveitis) and 40 healthy subjects, matched for sex and age.
Immunoscreening of the cDNA expression library
A commercially available HMVEC cDNA library (Stratagene, Cambridge, UK) was screened with a pool of sera from 2 of the 56 patients with BD, essentially as previously described [16]. The serum was diluted 1:100 in PBS containing 1% milk, 0.1% Tween-20 and 0.02% sodium azide. Positive plaques were re-screened with the same pool of sera to obtain the clonality. Immunoreactive cloned phage was recovered as pBluescript by single-stranded rescue using the helper phage (Stratagene) according to the manufacturer's instructions and used to transform SolR XL1 cells. The nucleotide sequence of the cloned cDNA insertion was sequenced with automated sequencer ABI Prism 310 collection (Applied Biosystems, Foster City, CA, USA) and sequences were then compared with the GenBank sequence database using the Blast program.
Expression and purification of the recombinant antigen
The selected cDNA clone was sub-cloned into the BamHI/HindIII restriction site of the QIA express vector, pQE30. The fusion protein was expressed in Escherichia coli SG130009 cells, purified by affinity of NI-NTA resin for the six-histidine tail and eluted under denaturing conditions according to the manufacturer's instruction (Qiagen, GmbH, Hilden, Germany).
SDS-PAGE and immunoblotting
After 12% SDS-PAGE under reducing conditions, immunoblotting was performed as previously described [17]. In brief, the antigen was loaded at concentrations of 3 μg/lane and was revealed by human sera diluted 1:100 and by a monoclonal antibody to six-histidine tail (Qiagen). Peroxidase-conjugated goat anti-human and anti-mouse IgG sera (Biorad, Richmond, CA, USA) were used as second antibodies. Strips were developed with 3'-3' diaminobenzidine (Sigma-Aldrich, St Louis, MO, USA).
Purification of specific autoantibodies from patients' sera
Antigen (50 μg) was spotted onto a nitrocellulose filter and incubated with a patient's serum that was positive in immunoblotting. After washing with PBS-Tween the antibodies were eluted with glycine 100 mM, pH 2.5, and mixed for 10 minutes. The eluted antibodies were immediately neutralized with TRIS-HCl 1 M, pH 8.
Indirect immunofluorescence assay
An indirect immunofluorescence assay was developed on permeabilized EAhy-926 endothelial cells, as previously described [18]. Cells were incubated with purified human antibodies (0.1 μg/μl) in PBS containing 1% bovine serum albumin. Fluorescein isothiocyanate-conjugated anti-human IgG (Sigma) was added and fluorescence was analysed with an Olympus U RFL microscope (Olympus, Hamburg, Germany). Anti-nuclear antibodies were detected using indirect immunofluorescence with Hep2 cells according to the manufacturer's instructions (Radim Diagnostic, Rome, Italy). Titers of more than 1:80 were considered positive.
ELISA was developed essentially as previously described [18]. In brief, polystyrene plates (Dynex, Berlin, Germany) were coated with the antigen (0.1 μg/well) in 0.05 μM NaHCO3 buffer, pH 9.5, and incubated overnight at 4°C. Plates were blocked with 100 μl/well of PBS-Tween containing 3% milk, for 1 hour at room temperature. Human sera were diluted in PBS-Tween and 1% milk (1:100 for total IgG and 1:50 for IgM and IgA), 100 μl per well. Peroxidase conjugates goat anti-human IgG (Biorad, Richmond, CA, USA), anti-human IgA (Sigma) and anti-human IgM (ICN Biomedicals, Costa Mesa, CA, USA) were diluted in PBS-Tween containing 1% milk (1:3,000, 1:3,000 and 1:500 respectively) and incubated 1 hour at room temperature. O-phenylenediamine dihydrochloride (Sigma) was used as a substrate and optical density (OD) was measured at 490 nm. Means + 2 standard deviations of the OD reading of the healthy controls were considered as cut-off level for positive reactions. All assays were performed in quadruplicate. Data were presented as the mean OD corrected for background (wells without coated antigen). The results of unknown samples on the plate were accepted if internal controls (two serum samples, one positive and one negative) had an absorbance reading within mean ± 10% of previous readings. To inhibit specific IgG, IgM and IgA, the sera from two patients with BD were incubated overnight at room temperature with 10 μg/ml of Sip1 C-ter according to the method reported by Huang and colleagues [19]. As a negative control, the sera was pre-incubated with 40 μg/ml of bovine serum albumin.
Soluble E-selectin was detected using a sandwich ELISA kit (R&D Systems, Minneapolis, MN, USA). ELISA was performed in accordance with the manufacturer's instructions.
Statistical analysis
Chi-square analysis was used to evaluate differences between percentages; Kruskal Wallis non-parametric ANOVA test and the Mann-Whitney unpaired test were used to compare quantitative variables. P values less than 0.05 were considered to indicate statistical significance. Pearson correlation (r correlation coefficient) and linear regression analysis were used to determine if the levels of soluble serum E-selectin correlated with the levels of anti-Sip1 C-ter antibodies in patients with BD
Immunoscreening of the HMVEC expression library
ELISA for IgG, IgM and IgA specific to Sip1 C-ter
Distribution of anti-Sip1 C-ter antibodies in sera from patients and from healthy donors
Serum samples
Number of total samples
Anti-Sip1 C-ter antibody response, number of positive samples (%)
Behçet's disease
11 (20)
23 (41)
9 (17)
Systemic lupus erythematosus
2 (6)
0 (0)
0 (0)
Systemic sclerosis
1 (4)
0 (0)
4 (17)
Primary vasculitis
1 (5)a
9 (45)b
3 (15)c
Inflammatory bowel disease
1 (3)
0 (0)
1 (3)
2 (11)
0 (0)
4 (23)
Healthy donors
2 (5)
0 (0)
3 (7)
Clinical manifestations of patients with Behçhet's disease in relation to anti-Sip1 C-ter autoantibodies
Clinical manifestation of the 56 patients with Behçet's disease
Number of total samples (%)
Anti-Sip1 C-ter antibody response, number of positive samples (%)
Skin lesions
36 (64)
7 (19)
14 (39)
7 (19)
Ocular inflammation
38 (68)
8 (21)
16 (42)
5 (13)
Genital aphtosis
27 (48)
5 (18)
8 (29)
5 (18)
10 (18)
1 (10)
6 (60)
2 (20)
Vascular manifestations
10 (18)
4 (40)
6 (60)
4 (40)
Neurological manifestations
6 (11)
1 (1.6)
Immunofluorescence analysis detected anti-nuclear antibodies in 7 of the 56 patients with BD (12.5%) at low titer (from 1:80 to 1:160). Five of these seven positive patients had serum antibodies specific to Sip1 C-ter (two patients had serum anti-Sip1 C-ter IgM, two anti-Sip1 C-ter IgM and IgG and one anti-Sip1 C-ter IgM and IgA).
In this study, by screening an HMVEC cDNA expression library to identify target antigens, we identified a strongly reactive clone encoding the carboxy-terminal subunit of the splicing factor Sip1 (Sip1 C-ter). The carboxy-terminal region of Sip1 – a novel endothelial autoantigen recognized by serum autoantibodies in patients with BD – may be a marker of endothelial dysfunction in vascular autoimmune diseases.
To our knowledge, this is the first report describing an immune response against the protein Sip1. Sip1 is a nuclear splicing factor containing an arginine/serine-rich domain and a RNA-binding motif that may play a role in linking the processes of transcription and pre-mRNA splicing [20]. How Sip1 might become an autoantigen exposed to the immune system and whether this process involves apoptosis need further investigations.
Apoptosis of endothelial cells may be initially induced by inflammation or oxidative stress caused by intrinsic or extrinsic factors. In this environment, mature dendritic cells would process and present Sip1, among other intracellular antigens, to autoreactive lymphocytes, thereby triggering the production of autoantibodies. Antibodies specific to Sip1 could in turn induce additional cellular damage by activating complement or through their cytotoxic properties, penetrating living cells. They might also merely reflect an immune response against antigens released from damaged endothelium. Another possible explanation for the immune response to Sip1 is molecular mimicry. Again, further investigations will clarify the possible cross-reaction with molecules from microorganisms associated with BD and Sip1. Using a molecular strategy to identify autoantigens in BD, Lu and colleagues [4] immunoscreened a T24 cDNA expression library and identified kinectin as a BD autoantigen. Presumably our study and that of Lu and colleagues identified different molecular targets because the cDNA libraries and patient populations differed.
In this study, we used ELISA to analyse Sip1 C-ter immunoreactivity to IgG, IgA and IgM, three immunoglobulin classes potentially involved in the pathogenesis of BD. Kruskal-Wallis test showed that the immunoreactivity of IgM, IgG and IgA specific to Sip1 C-ter varied significantly among various groups of patients analysed. The precise significance of the isotypes of anti-Sip1 antibodies and their potentially independent clinical role remains unclear.
Another important question to clarify is whether distinct autoantibody isotypes recognize different Sip1 epitopes. IgM specific to Sip1 C-ter achieved the highest prevalence and the highest specificity in patients with BD and with vasculitis. Autoimmune diseases can be associated with elevated levels of IgM autoantibodies that may have a pathogenic effect [21]. In particular, IgM antibodies might have an important role in the pathogenesis of BD and high IgM deposition has been found in papulopustular lesions, the most common type of cutaneous lesions in BD and in the vessels of the lesional skin [22].
In patients with BD, anti-endothelium IgM is more frequent than anti-endothelium IgG and is associated with vasculitis [23]. In a recent study using proteomic technology to identify a protein of human dermal microvascular endothelial cells that reacts with anti-endothelial cell antibodies of patients with BD, Lee and colleagues [2] identified α-enolase, another ubiquitous protein, as an autoantigen recognized by serum IgM from patients with BD, thus confirming the importance of anti-endothelium IgM in BD.
The target antigens, Sip1 in our study and α-enolase in the study by Lee and colleagues, were recognized only by IgM of patients with BD and patients with other forms of primary vasculitis, whereas no serum from patients with other autoimmune diseases or from healthy subjects had specific IgM with an OD reading in ELISA higher than the cutoff level. The presence of IgM specific to Sip1 only in the sera from patients with primary vascular disease as well as the positive correlation of serum IgM specific to Sip1 C-ter with the serum levels of soluble E-selectin, a typical marker of endothelial activation and inflammation, suggests the potential role of these antibodies as immunological markers of endothelial dysfunction [24].
The role of IgA specific to Sip1 C-ter in patients with various diseases needs further investigation in a larger sample of patients. Because IgA is a poor activator of complement, this class of immunoglobulins may have a protective function inhibiting complement activation by blocking the binding of IgG or IgM antibodies [25]. Although Sip1 is a nuclear protein, in patients with BD we found no association between serum anti-Sip1 antibodies and anti-nuclear antibodies, probably because we used different techniques to reveal the two antibodies. Further studies are in progress to clarify the effective role of anti-Sip 1 antibodies in vivo and to provide new insights into their potential pathogenicity.
One way of improving the diagnosis of BD is to characterize new autoantigens for use in immunodiagnostic tests. In this study, we identified Sip1 C-ter as a novel autoantigen in BD. Anti-Sip1 C-ter IgM should be useful as a marker of endothelial dysfunction in vasculitis. This recombinant antigen might also provide new insights into the role of specific autoantibodies in the autoimmune mechanisms underlying the pathogenesis of BD.
Behçet's disease
enzyme-linked immunosorbent assay
human microvascular endothelial cells
inflammatory bowel disease
optical density
phosphate-buffered saline
- Sip1 C-ter:
carboxy-terminal subunit of Sip1
systemic lupus erythematosus
- SSc:
systemic sclerosis
We thank Professor Francesco Vecchi for assistance with statistical analysis. This work was supported by an ISS grant n. C3N3 and AE13.
Authors' Affiliations
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- Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D: Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease. Arthritis Rheum. 2003, 48: 2025-2035. 10.1002/art.11074.View ArticlePubMedGoogle Scholar
- Priori R, Conti F, Pittoni V, Garofalo T, Sorice M, Valesini G: Is there a role for anti-phospholipid-binding-protein antibodies in the pathogenesis of thrombosis in Behçet's disease?. Thromb Haemost. 2000, 83: 173-174.PubMedGoogle Scholar
- Lu Y, Ye P, Chen S, Tan EM, Chan EKL: Identification of kinectin as a novel Behçet's disease autoantigen. Arthritis Res Ther. 2005, 7: R1133-R1139. 10.1186/ar1798.PubMed CentralView ArticlePubMedGoogle Scholar
- Navarro M, Cervera R, Font J, Reverter JC, Monteagudo J, Escolar G, Lopez-Soto A, Ordinas A, Ingelmo M: Anti-endothelial cell antibodies in systemic autoimmune diseases: prevalence and clinical significance. Lupus. 1997, 6: 521-526.View ArticlePubMedGoogle Scholar
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- Matsui T, Otsuka M, Maenaka K, Furukawa H, Yabe T, Yamamoto K, Nishioka K, Kato T: Detection of autoantibodies to killer immunoglobulin-like receptors using recombinant fusion proteins for two killer immunoglobulin-like receptors in patients with systemic autoimmune diseases. Arthritis Rheum. 2001, 44: 384-388. 10.1002/1529-0131(200102)44:2<384::AID-ANR57>3.0.CO;2-Z.View ArticlePubMedGoogle Scholar
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- Matsui T, Kurokawa M, Kobata T, Oki S, Azuma M, Tohma S, Inoue T, Yamamoto K, Nishioka K, Kato T: Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases. J Immunol. 1999, 162: 4328-4335.PubMedGoogle Scholar
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- Shoenfeld Y: Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: the pathogenic and diagnostic implications. Cleve Clin J Med. 2002, 69 (Suppl 2): SII65-67.PubMedGoogle Scholar
- International Study Group for Behçet's Disease: Criteria for diagnosis of Behçet's Disease. Lancet. 1990, 335: 1078-1080.Google Scholar
- Hochberg MC: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997, 40: 1725-View ArticlePubMedGoogle Scholar
- Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 1980, 23: 581-590.View ArticleGoogle Scholar
- Margutti P, Delunardo F, Sorice M, Valesini G, Alessandri C, Capoano R, Profumo E, Siracusano A, Salvati B, Riganò R, Ortona E: Screening of a HUAEC cDNA library identifies actin as a candidate autoantigen associated with carotid atherosclerosis. Clin Exp Immunol. 2004, 137: 209-215. 10.1111/j.1365-2249.2004.02491.x.PubMed CentralView ArticlePubMedGoogle Scholar
- Margutti P, Ortona E, Vaccari S, Barca S, Riganò R, Teggi A, Muhschlegel F, Frosch M, Siracusano A: Cloning and expression of a cDNA encoding an elongation factor 1 β/δ protein from Echinococcus granulosus with immunogenic activity. Parasite Immunol. 1999, 21: 485-492. 10.1046/j.1365-3024.1999.00246.x.View ArticlePubMedGoogle Scholar
- Margutti P, Sorice M, Conti F, Delunardo F, Racaniello M, Alessandri C, Siracusano A, Riganò R, Profumo E, Valesini G, Ortona E: Screening of an endothelial cDNA library identifies the carboxy-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations. Arthritis Res Ther. 2005, 7: R896-R903. 10.1186/ar1759.PubMed CentralView ArticlePubMedGoogle Scholar
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- Zhang WJ, Wu JY: Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. Mol Cell Biol. 1998, 18: 676-684.PubMed CentralView ArticlePubMedGoogle Scholar
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- Lee KH, Bang D, Choi ES, Chun WH, Lee ES, Lee S: Presence of circulating antibodies to a disease-specific antigen on cultured human dermal microvascular endothelial cells in patients with Behçet's disease. Arch Dermatol Res. 1999, 291: 374-381. 10.1007/s004030050425.View ArticlePubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Aquinas, Aristotle, and the Promise of the Common Good
By (author) Mary M. Keys
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Aquinas, Aristotle, and the Promise of the Common Good by Mary M. Keys
Book DescriptionAquinas, Aristotle, and the Promise of the Common Good, first published in 2006, claims that contemporary theory and practice have much to gain from engaging Aquinas's normative concept of the common good and his way of reconciling religion, philosophy, and politics. Examining the relationship between personal and common goods, and the relation of virtue and law to both, Mary M. Keys shows why Aquinas should be read in addition to Aristotle on these perennial questions. She focuses on Aquinas's Commentaries as mediating statements between Aristotle's Nicomachean Ethics and Politics and Aquinas's own Summa Theologiae, showing how this serves as the missing link for grasping Aquinas's understanding of Aristotle's thought. Keys argues provocatively that Aquinas's Christian faith opens up new panoramas and possibilities for philosophical inquiry and insights into ethics and politics. Her book shows how religious faith can assist sound philosophical inquiry into the foundation and proper purposes of society and politics.
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Book DetailsISBN: 9780521864732
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Publish Date: 18-Sep-2006
Country of Publication: United Kingdom
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This book, first published in 2006, shows how religious faith can assist philosophical inquiry in the purposes of society and politics.
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Author Biography - Mary M. Keys
Mary M. Keys is Assistant Professor of Political Science at the University of Notre Dame. She has received fellowships from the Erasmus Institute, University of Notre Dame, the Martin Marty Center for Advanced Study of Religion at the University of Chicago, and the George Strake Foundation, among others. Her articles have appeared in American Journal of Political Science and History of Political Thought.
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What is your opinion of the top 10 posters:
rage patton
Mr. Nipples...
Do you ever see your self being a dad?
Have you ever done anything illegal? If so, share an anecdote. You seem to be good at that.
Anecdotes that is.
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a) on a sail boat to hawaii
b) in a mountain chalet snowed in
Have Another Hit Of Colorado Sunshine
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Episode 1, 2, or 3? explain
List the top 5 live performances you have seen in your lifetime.
You have just been made Supreme Ruler of the World. What do you do with your new title and powers?
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In order to get a life time of love from your dream girl/man and a comfortable living situation (house, money, car, etc) all you have to do is cut off all your family and friends (including this board) forever, would you? What's this dream person like if you do or don't?
Mr. Nipples.
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Mr Nipples,
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take them to the bathroom with you.
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the busy bee has no time for sorrow.
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"Who is this doing this synthetic type of Alpha Beta psychedelic funkin'?"
Everything worked out in the end quite well. I'm lighter and fresher.
Was the roll over or under?
Whiskey Sour
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1/2 tsp powdered sugar
1 cherry
1/2 slice lemon
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It's one of those industrial dispensers, so I'm not sure. Considering the set-up, I'm gonna guess overer, but it kind of depends on how you look at it.


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Cheese 'N' Bacon Topped Potato
|Baking potato
|5 Ounce, scrubbed
|Reduced fat swiss cheese
|3⁄4 Ounce, divided
|Reduced fat shredded swiss cheese
|3⁄4 Ounce, divided
|Plain low-fat yogurt
|2 Tablespoon
|1 Teaspoon, chopped
|1 Teaspoon
|Reduced calorie mayonnaise
|1 Teaspoon
|Bacon bits
|1 Teaspoon, divided (Made From Real Bacon)
|1 Dash
1. Using a fork, pierce potato all over.
2. In a microwaveable plate, place potato and cook on High for 5 minutes; ½ rotate the plate in between cooking.
3. Let the potatoes stand for 1 minute.
4. Lengthwise cut the potato into half.
5. Leaving 1/4-inch-thick shells scoop out the pulp from the potato halves; keep the shells aside.
6. In a large mixing bowl, put together potato pulp, 1/2 ounce cheese, the yogurt, chives, mayonnaise, 1/2 teaspoon bacon bits, and the pepper; mix well.
7. Stuff the potatoes with the potato pulp mixture.
8. In a baking dish, place the stuffed potato and sprinkle remaining cheese and bacon bits.
9. Keep the baking sheet in the oven and cook on High for 1 minute until the cheese is just melted.
10. Serve immediately.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 113 Calories from Fat 37
% Daily Value*
Total Fat 4 g6.3%
Saturated Fat 1.3 g6.7%
Trans Fat 0 g
Cholesterol 7.9 mg2.6%
Sodium 138.4 mg5.8%
Total Carbohydrates 15 g4.9%
Dietary Fiber 0.99 g4%
Sugars 1.7 g
Protein 5 g9.2%
Vitamin A 2.5% Vitamin C 9.4%
Calcium 3.9% Iron 3.7%
*Based on a 2000 Calorie diet


text:
Ming Li, National Research Council Canada, Institute for Microstructural Science, Ottawa, Canada, and Anders Larsson, Chalmers Univ. of Technology, Dept. of Optoelectronics, Gothenburg, Sweden.
A novel scheme to build a miniature, synthetic (or 'computer-generated') hologram on the surface of an optical waveguide has been proposed and experimentally demonstrated. Such a hologram is not much larger than the tip of a human hair. This new type of computer-generated hologram is capable of coupling light out of an optical waveguide, thereby leading to its name, off-plane computer-generated waveguide hologram (OP-CGWH), and simultaneously forming a predefined image at a certain distance above the waveguide surface.
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Publish Date: 01 December 1997


text:
Please read! If you are interested in me, please visit my site, www.breederadoptions.org, read the Policies and Procedures and the FAQs page, complete the application, and my rescuers will contact you promptly. Thank you.
Hi! My name is Molly and I am a super sweet, very overweight Pomeranian girl who is 10 years old and I weigh 24 pounds. My owner got sick and I was headed to the pound where I surely would have been put to sleep but some very nice folks saved me! I was so matted that I had to be shaved to skin but I feel so much better! My coat is a beautiful bronze color and it will grow out again. I need a quiet home and someone who will take me for walks so I can get rid of some of this fat. I am house trained and am no trouble at all, I just need love. If you can help me get my girlish figure back, please ask for me on your application.
Love, Molly 062316-01
Thank You!
Your message has been sent to BRAS - Farmington, NM.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


text:
This is far funnier than it has any right to be.
If you're a fan of both the ludicrous action films of Arnold Schwarzenegger and unapologetic potty humor, then today should feel like Christmas: YouTube's DistractotronChannel just delivered a four-minute reel of the ex-governor's finest onscreen moments—masterfully mixing fart sound effects into each one. Not impressed? You will be.
Yes, between Ah-nold's strained faces and clunky line deliveries, not to mention the bemused reactions of his many co-stars (Carl Weathers in Predator is especially but justifiably alarmed), this montage proves that a sophomoric joke done well can get the better of anyone.
I think we all now have a pretty good idea what The Expendables 3 is about.
Photo via DistractotronChannel/YouTube
Meet Apple's newest fart-game developers: They're my mom and dad
When my mom and dad first told me they were building an iPhone app, I was supportive but skeptical. My parents, 58 and 62, weren't developers or techies; they use 2005-era flip phones instead of iPhones. But now I'm holding their work in my hand, and I couldn't be prouder.
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text:
Team USA came into the 2004 Ryder Cup at Oakland Hills Country Club in Bloomfield Township, Mich., with the idea of teaming up the top two ranked players in the world: Tiger Woods and Phil Mickelson. Unfortunately for the Americans, the combination never clicked.
Team Europe got early momentum when Colin Montgomerie and Padraig Harrington beat Woods and Mickelson in Friday morning fourballs, and the Europeans never slowed up. By the end of Friday's matches, Team Europe held a 6 1/2 to 1 1/2 lead and the tandem of Woods and Mickelson had lost a second time.
When all was said and done on Sunday, the Europeans walked away with a 18 1/2 to 9 1/2 win, their largest victory in the history of the event.
Here's a breakdown of the 2004 match:


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We wanted to thank you and your staff for the brilliant service, advice and patience you gave us whilst trying to purchase our home. Without your guidance and experience, we would never have got our beautiful new house.Peter and Nathalie
Tony is certainly one of, if not the most honourable and trustworthy people I have ever had the opportunity to meet, I cannot recommend him strongly enough and would encourage anyone looking for financial advice or any of the other services Y-Not offer to try Tony's at least once.Geoff Girdler - Executive Director at Capstan Communications Limited
I have known Tony for many years and wouldn't hesitate to endorse him and his work.Stephen Matthew - Owner, Matthew & Matthew
Amazing friendly service, tony and Billie have been amazing. Invaluable knowledge and there at all times of the day (even called me from Spain!!). Miss S Ricketts
Just awesome, can't recommend them enough. Miss R Johnson
Superb service and advice. Saving me time and always reply promptly to enquiries. Mr M Constable.


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This review is from: SAPPHIRE VAPOR-X Radeon R9 290 DirectX 11.2 100362VXSR 4GB 512-Bit GDDR5 PCI Express 3.0 CrossFireX Support TRI-X OC (UEFI) Video Card
Pros: Looks very attractive and has a nice looking design with cool LED temperature indicator.
Cons: Everything about this card is a con, I have RMA the card already after 34 days of ownership they made me pay the shipping, now I have the new card and it is going constant black screen, Sapphire wants me to wait 2weeks again and pay shipping, this is not a good company to deal with save your self some trouble and think long and hard before you buy this. My experience with this card has been stressful and very heartbreaking when you spend $500.00 on a card you expect it to work better than a $180 xfx 7870 but my 7870 outperforms this card both the old one and the recent RMA, I am in the process of another RMA and I refuse to wait and pay again. I am moving over to the GREEN TEAM after this experience. So hopefully this will help you make your decision after hearing my problems that have been non stop since day 1. I know it is not my system because I have done fresh windows install with both cards and my 7870 works perfectly fine with no problems, I even went so far as to install my friends r9 270x and guess what it works perfect I got smoother game play in games than with the 290
Other Thoughts: Maybe someone else has had a good or will have a experience but not me. Good luck if you press the submit order button. If I could get a refund I would buy a Nvidia 780 not even a Ti I bet that would work just fine.READ FULL REVIEW
This review is from: XFX Core Edition Radeon HD 7870 GHz Edition DirectX 11 FX-787A-CNFC 2GB 256-Bit GDDR5 PCI Express 3.0 x16 HDCP Ready CrossFireX Support Video Card
Pros: This card does pack a punch for the price it runs all games I can throw at it if you trying to stay on a budget this is the perfect card for the price.
Cons: This card does tend to run a little hot at times when games are set to ultra I changed my cooler to an
Artic Accelero Twin Turbo II that solved and heating problems
Other Thoughts: I get really good frame rates for this card I am very pleased by it and plan to upgrade to a 7970 in the near future XFX is a great card. I am not gonna drop an egg because I had to change the cooler to make me feel safer with the temps they were probably ok I am just picky on temps getting up to 70c it makes me feel uncomfortable.READ FULL REVIEW
This review is from: ARCTIC Accelero TT II VGA Cooler - nVidia & AMD, Dual Quiet 92mm PWM Fans, SLI/CrossFire
Pros: Very quiet at full speed and cools way better than the factory installed cooler. Install was very simple once you understand what to do you have to go over directions a few times and you will have it I definitely recommend this to anybody having a heat problem with their GPU
Cons: It is kinda big so it will take away some room especially if you run SLI or CrossFire. Directions could be a little better presented.
Other Thoughts: This thing did the job for me my xfx 7870 GHz edition was hitting 74c when I would take BF3 to ultra now I only see 42c to 44c. It really is a great solution if you're worried about you GPU getting too hot like I was. Install was very easy it may take you time to figure out what to do but it is not that hard the directions are a little too simplified but you get the just of what to do.READ FULL REVIEW


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Women's Blue Whisper Cotton Crewneck Tee
It's no secret, our best-selling crewneck tee (formerly called Slub Crewneck Tee) is the kind of forever favorite you'll want in every color. Fashioned of light and airy slub cotton, this T-shirt is live-in-it soft and perfectly draped—one to tell your friends about, in other words. True to size. Cotton. Machine wash. Madewell. Com only. For complete details, see our Shipping Policy and Return Policy. Color: blue