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More Videos...
Triumph Tiger 800 ridden!
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2011-2012 Suzuki GSX-R 600 Technische Details
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JJ Lin's Timeline World Tour.
S'pore stop for JJ Lin's world tour
SINGAPORE — JJ Lin will be returning with a bang for the Singapore leg of his JJ Lin Timeline World Tour at the Singapore Indoor Stadium on Nov 9.
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The JJ Lin Timeline World Tour kicked off in Taipei in early July. Aside from his Singapore date, Lin also performs in Malaysia, Shanghai, Hong Kong, Atlantic City, Las Vegas, London, Sydney and Melbourne.
The JJ Lin Timeline World Tour concert is on Nov 9, 8pm, Singapore Indoor Stadium. Tickets from S$88 at Sistic.


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Adrian Rogers
Adrian Rogers (1931 - 2005) was one of America's most respected Bible teachers, communicating to millions through his "Love Worth Finding" radio and television ministry that continues today. He was also senior pastor of the 27,000-member Bellevue Baptist Church near Memphis, Tennessee, and authored such popular books as "Unveiling the End Times in Our Time, What Every Christian Ought to Know, " and "The Incredible Power of Kingdom Authority".
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Adrian Rogers, Dr. Adrian Rogers, Steve Rogers$14.99Add Your Review"The one who reads this is blessed, and those who hear the words of this prophecy and keep what is written in it are blessed, because the time is near " -Revelation 1:3 (HCSB) Respected Bible teacher and beloved pastor Adrian Rogers takes readers on a breathtaking journey th... Learn More
What Every Christian Ought to Know Day by Day: Essential Truths for Growing Your Faith
Adrian Rogers$15.99Add Your ReviewThe internationally revered teaching of the late Adrian Rogers lives on in this day-by-day adaptation of his acclaimed final book, "What Every Christian Ought to Know," Just as plants need essentials to grow--light, water and fertile soil--so do Christians who want to develo... Learn More
Family Survival in an X-Rated World: A Practical Program for Guarding Your Heart and Protecting Your Home
Adrian Rogers, Steve Rogers, Zig Ziglar$12.99Add Your ReviewThere is no doubt that there is a war for the morality of this culture being waged and the battle ground is the homes across this nation. No where is this more acutely felt than in the breakdown of the American family. Immorality of all shapes and sizes is available, afforda... Learn More
Ten Secrets for a Successful Family
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A Southern California native, Emilio Villalba received his BFA from the Art Institute of California in 2006, and his MFA in Painting from the Academy of Art University in 2011. He currently lives in San Francisco where he teaches at the Art Institute of California and Cogswell College.
Sarah Joncas was born in 1986 and grew up in both Hamilton and Niagara Falls, Ontario. Her interest in the visual arts developed at an early age, starting with the dedicated drawings of dinosaurs and lizards. Eventually the study and enjoyment of working from existing images stirred up the need in Sarah to create images of her own; ones that could reflect the world, yet also appease the personal feelings/ideas that she maintained. With this, her direction changed gradually from the world of animation, towards a path in fine art. Sarah graduated from the Ontario College of Art and Design's BFA program. She currently resides and works out of Toronto, Canada.
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The candidate seeks career development support that will build on her interdisciplinary training in toxicology and environmental epidemiology and enable her to advance her scientific career by investigating the possible contribution of DDT exposure in early life to risk of the metabolic syndrome and diabetes. The scientific goal is to test the hypothesis that perinatal exposure to DDT increases risk of metabolic syndrome in aging adults in a dose-dependent manner. The candidate proposes an integrated series of toxicologic and epidemiologic studies. The toxicologic studies (K99 MENTORED PHASE) will incorporate dynamic in vivo physiologic techniques such as metabolic tracers and euglycemic clamping developed in medical endocrinology to explore tissue specific mechanisms of perinatal DDT toxicity in mice. The independent (R00 PHASE) will involve follow-up of the now middle-aged daughters of women who participated in the Child Health and Development Studies birth cohort study in California over 40 years ago and will involve inter-generational life course analyses. The independent phase will conclude with research seeking to identify biomarkers of DDT metabolic toxicity in mice. Metabolic syndrome, often associated with obesity and diabetes, affects over 47 million US residents. Prevalence has increased rapidly in the past decade. The possibility of a toxic environmental chemical contribution to this upward trend is relatively unexplored. There are however, human and mechanistic laboratory data suggesting that organochlorine pesticides, DDT among them, are associated with increased risk of diabetes and the metabolic syndrome. DDT was used extensively in the US until 1972 and is still much used worldwide in malaria control. At the conclusion of training, the candidate will transition to an independent career focused on elucidation of the mechanisms of perinatal exposures involved in metabolic and endocrine dysfunction. These studies should lead to a better understanding of the possible role of environmental toxicants in the etiology of metabolic syndrome and diabetes and will establish a strongly interdisciplinary foundation for the candidate's future research.
This research training program examines the influence of exposure to the insecticide DDT during early development on the rise of obesity, diabetes, high cholesterol and high blood pressure. High body burdens of DDT are found among adults born before its ban in the US in 1972 and in persons of all ages who have lived in regions where DDT continues to be used extensively for malaria control. The ultimate goal of this work is to understand the possible contribution of DDT to metabolic syndrome and to use this information to design strategies for the prevention of metabolic syndrome.
|La Merrill, Michele; Karey, Emma; Moshier, Erin et al. (2014) Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PLoS One 9:e103337


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The pink and purple is stunning. The cream and purple plicata looks
interesting, does it have Progressive Attitude in it's breeding. The
blue-violet looks like many others, unless it has an especially high bud
count or multiple rebloom.
Colleen Modra
Impressive Irises
PO Box 169
Charleston SA 5244
----- Original Message -----
From: "Mike Sutton" <firstname.lastname@example.com>
To: <firstname.lastname@example.com>
Sent: Wednesday, July 02, 2003 4:34 AM
Subject: [iris-photos] RE: seedlings #3
Last posting. some more under consideration for introduction next year. all
have rebloomed this year. input would be appreciated. all have at least
adequate branching and bud count and vigor.
Mike Sutton
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U2's Adam Clayton Says 'Songs of Experience' will be Out This YearThe band's 'Joshua Tree' tour may influence the album's ultimate sound.
U2, Red Hot Chili Peppers, the Weeknd To Headline Bonnaroo FestivalThe lineup also includes Chance the Rapper, Major Lazer, Lorde, Travis Scott, Cage the Elephant, Tory Lanez and Tove Lo.
U2 Announce Joshua Tree TourThe tour kicks off May 12 in Vancouver, and includes the Bonnaroo festival, their first U.S. festival date.
U2: Ranking the Songs and B-Sides from 'The Joshua Tree'Every song is a classic and there were some great B-sides, too.
U2 to Play Special 'Joshua Tree' Rose Bowl Show: ReportIt now appears we may see the band reveal significant news about these shows as soon as next week.
U2 to Celebrate 'Joshua Tree' 30th Anniversary, Release New Album in 2017It looks like they'll be doing some special shows commemorating the anniversary of their classic 1987 album.
Ride a Jet Ski with DJ Khaled and Fight HIVBono, Liam Payne and many other musicians and celebrities are also offering experiences to raise money for charity.
Bono Reads Mean Tweets at 'Woman of the Year' Ceremony"The transition lenses do make him look like a 75 year old lady from Miami," read one tweet.
U2: New Album May Be Out in the Spring"May" is the operative word. Bassist Adam Clayton won't confirm anything.
U2 Attack Donald Trump in Impassioned Rant"Good people are not gonna stay silent while you run off with the American dream. You hear me candidate, you're fired!"
Taylor Swift and U2 Lobby Congress for Streaming ReformsSwift has become a vocal proponent of fair compensation for artists whose music appears on popular streaming platforms
U2 Announce Release of Paris Concert FilmThe band played the French capitol just weeks after a terrorist group attacked the city.


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This is the first time in over four decades that I don't have a mother on Mother's Day. Mom's name was Agnes Johnson. She was sixty-four.
We admitted her to Fort Sanders Hospital in Knoxville on January 26. The doctors did everything they could to save her but they were unsuccessful. They gave her a hysterectomy and amputated her left leg. They tried to wean her off the respirator a few times but they were unable to.
On March 4 my brother and I had to make a hard and painful decision. We decided to have her taken off the respirator. We did that because she couldn't get better and she was suffering.
She died 1 or 2 AM on March 6. When I woke, I saw that she had passed. I hope nobody else has to make the same decision that we did.
Mom was a very special person. For several years she gave money to the homeless and to the Oral Roberts Ministry. She also gave 15-20 giant print bibles to people.
Let me give you an example of how nice she was. When I was at Kmart in 1979, I had enough money to buy one record. I was looking at two records and was trying to decide which one to buy. Here came Mom and bought one of the records for me so I could have both. That act of kindness is something I'll always remember.
Mom truly cared about others. Most people who met her, liked her. She was a great mom and a great person. May she rest in peace.
© Copyright 2017 RJohnson. All rights reserved.
Status: Finished
Genre: Non-Fiction
This brought tears to my eyes. It sounds like an incredibly tragic way to die, and my heart really goes out to you.
Poem / Poetry
Poem / Poetry
Poem / Poetry
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University Hospital of Brooklyn Annual Health Fair
8014 3rd Ave
Brooklyn, NY
related issues:
There will be a wide variety of health screenings available, including asthma, blood pressure, breast cancer, cervical cancer, colon cancer, head and neck cancer, cholesterol, hearing, stroke, sleep disorders, prostate, glaucoma, vision, memory, and more. The event will also include giveaways and free refreshments. Attractions include an inflatable bouncer; the Brooklyn Nets Basketball Team Mobile Interactive Unit; a clown; music by a DJ; face painting; fitness and aerobics instructor Quinn Harris; the New York Pan Stars Steel Band; and pony rides.
How a Bill Becomes LawLearn More
Senator has new policy idea
Idea is drafted into a Bill
Bill undergoes committee process
Senate and Assembly pass bill
Bill is signed by Governor


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In the next five years, the city of San Diego will have to increase its spending on stormwater projects an average of $164 million annually, more than it costs to run its park and library systems combined.
To help pay for this, the city could increase homeowners' monthly stormwater fees by more than 1,000 percent, though any increase would require a public vote. If the city doesn't find the money, it could face up to $37,500 in daily fines every time it pollutes the ocean.
"That's a little sobering," City Councilman David Alvarez said Wednesday after hearing a report with all these numbers.
The astronomical figures punctuate a long-running tension for the city over whether to chip away at the backlog of broken infrastructure or build new things residents need.


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It was beautiful here too. Around 60 degrees. This was my "opening day" of
the gardening season -- it was the 1st day for me this year that I actually
got to spend working in the yard. I spent the whole day outside cleaning up
the pond, cleaning the yard and working on one of my gardening beds.
Lesson learned on day 1 of the gardening season: SUNBLOCK, SUNBLOCK,
I have to remember that next time. The back of my neck is wicked badly
sunburned. BRIGHT RED! Youch, it hurts.
Long Island, NY
Zone 6/7
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Thesaurus: synonyms and related words
Meaning of "High Court of Australia" in the English Dictionary
(Definition of "High Court of Australia" from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press)
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Get a quick, free translation!
- High Commission
- High Commissioner
- high coupon
- High Court
- High Court of Australia
- high def
- high definition
- high explosive
- high fidelity
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Word of the Day
the part of a cooker with a door, used to bake or roast food


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Infliximab in ankylosing spondylitis: alone or in combination with methotrexate? A pharmacokinetic comparative study
DOI: 10.1186/ar3350
© Mulleman et al. licensee BioMed Central Ltd. 2011
Received: 11 February 2011
Accepted: 3 June 2011
Published: 3 June 2011
Methotrexate (MTX) has been shown to modify infliximab pharmacokinetics in rheumatoid arthritis. However, its combination with infliximab in the treatment of ankylosing spondylitis (AS) is not recommended. The objective of this study was to examine the influence of MTX on infliximab exposure in patients with AS.
Patients with AS patients who had predominantly axial symptoms were randomised to receive infliximab alone (infusions of 5 mg/kg at weeks 0, 2, 6, 12 and 18) or infliximab combined with MTX (10 mg/week). Infliximab concentrations were measured before and 2 hours after each infusion and at 1, 3, 4, 5, 8, 10, 14 and 18 weeks. We estimated individual cumulative area under the concentration versus time curves (AUC) for infliximab concentration between baseline and week 18 (AUC0-18). Clinical and laboratory evaluations were performed at each visit. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was the primary end point for clinical response.
Twenty-six patients were included (infliximab group: n = 12, infliximab + MTX group: n = 14), and 507 serum samples were available for measurement of infliximab concentration. The two groups did not differ with regard to AUC0-18 or evolution of BASDAI scores and biomarkers of inflammation.
The combination of MTX and infliximab does not increase the exposure to infliximab over infliximab alone in patients with AS.
Trial registration
ClinicalTrials.gov: NCT00507403
Infliximab, a chimeric monoclonal antibody to TNF-α, showed efficacy for ankylosing spondylitis (AS) in a randomised, placebo-controlled trial in which 61.2% of the patients were responders at 24 weeks [1]. Although methotrexate (MTX) is often used for patients with predominantly peripheral AS and those with psoriatic arthritis, the few attempts to treat predominantly axial disease were disappointing. Haibel et al. [2] studied 20 patients with AS who received MTX 15 to 20 mg/week subcutaneously and found no difference in Assessment in Ankylosing Spondylitis 20% improvement criteria (ASAS 20) scores before and 16 weeks after treatment. Until now, MTX has been evaluated in only three small, randomised, controlled trials [3–5], and a Cochrane review [6] concluded that there was insufficient evidence to support the use of MTX for AS with predominantly axial symptoms.
Data comparing infliximab with and without MTX treatment in AS are sparse and conflicting. Pérez-Guijo et al. [7] found a greater reduction in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores with infliximab + MTX treatment than with infliximab alone, whereas Breban et al. [8] found no statistically significant difference between patients who did or did not receive MTX in a subset of AS patients receiving treatment with infliximab by an on-demand strategy. However, in the latter study, patients receiving MTX showed a better response and fewer reactions to infusions than did patients not receiving MTX, although the results were not statistically significant [8]. Currently, regarding TNF-α antagonist therapy for patients with AS or psoriatic arthritis, the French Society for Rheumatology recommendations suggest that there is insufficient evidence for concomitant disease-modifying antirheumatic drugs improving the effectiveness of TNF-α antagonist therapy [9].
To date, no study has used infliximab exposure as an end point to compare treatment with the combination of infliximab and MTX with infliximab alone in AS with predominantly axial symptoms. Indeed, if such a combination increases exposure to infliximab, it should improve response and may be recommended in clinical practice. In the present study, we compared the individual exposure to infliximab of AS patients with predominantly axial symptoms receiving infliximab alone or infliximab and MTX combined.
Materials and methods
Patients and study protocol
From January 2008 to April 2009, AS patients with predominantly axial symptoms were recruited to participate in this two-centre, open-label, prospective, randomised study comparing treatment with infliximab alone and infliximab with MTX. All patients fulfilled the New York revised criteria for AS [10]. Infliximab was given intravenously (5 mg/kg) at weeks 0, 2, 6, 12 and 18 in accordance with our guidelines [9]. MTX 10 mg was given orally every week. After patients were randomised to a treatment group, a total of 12 visits were scheduled at each infliximab infusion and between infusions at 1, 3, 4, 5, 8, 10 and 14 weeks. Blood samples were collected before and two hours after the end of each infusion and at each visit. We estimated that we needed about 30 patients to compare infliximab exposure between the two treatment groups. The study protocol was in compliance with the Declaration of Helsinki, approved by the ethic committee of Tours University Hospital and registered (ClinicalTrials.gov ID: NCT00507403). All patients gave their informed consent to participate in the study.
Clinical measurements
At each visit, patients were asked to complete a BASDAI questionnaire and were classified as responders if their BASDAI score (on a 10-point scale) at week 18 was two points lower than at baseline [9, 11]. Treatment response was also assessed according to the Assessment in Ankylosing Spondylitis 20% improvement criteria (ASAS 20).
Serum infliximab and antibodies toward infliximab concentrations
Analyses of serum infliximab and antibody toward infliximab (ATI) concentrations were centralised in Tours University Hospital. Infliximab serum concentration was measured in samples by using ELISA as described previously [12]. Serum concentration of ATI was measured by using a double-antigen ELISA on the basis of capture by infliximab-coated microplates and detection by peroxidase-conjugated infliximab. This assay was standardised by the use of a mouse monoclonal antibody against human immunoglobulin G. The positive threshold of detection was 0.07 mg/L. Because of the interference of circulating infliximab, only sera with infliximab concentrations < 2 mg/L were tested.
Statistical analysis
Baseline characteristics of 26 patients with ankylosing spondylitis and predominantly axial symptoms randomised to receive infliximab or infliximab + methotrexatea
(n = 12)
Infliximab + MTX
(n = 14)
P value
Sex, men/women (n/%)
9/3 (75/25)
11/3 (79/21)
Median age, years
42.5 [27 to 59]
45.5 [29 to 55]
Median disease duration, years
4.0 [0 to 28]
4.5 [1 to 19]
Human leukocyte antigen B27+, n (%)
9 (75)
10 (71)
NSAIDs, n (%)
8 (67)
12 (86)
Previous TNF-α, n (%)
2 (17)
2 (14)
Median BASDAI score
5.8 [3.9 to 8.4]
7.0 [5.0 to 8.2]
Median C-reactive protein, mg/L
3.6 [0.5 to 18.0]
2.7 [0.5 to 31.2]
The two groups did not differ with regard to clinical activity or inflammation. Responses between the two groups were similar at week 18 (Additional file 1). Responders displayed a rapid decrease in BASDAI score compared with nonresponders, with a statistically significant difference observed at week 6 and thereafter (Additional file 2). The proportions of previous anti-TNF-α and current NSAIDs were similar in both responders and nonresponders.
We did not observe any influence of MTX on infliximab exposure in AS patients with predominantly axial symptoms. Our study is the first to answer the question whether MTX may affect infliximab pharmacokinetics in AS with predominantly axial symptoms. Previously, Krisiek et al. [14] analysed blood samples from AS patients receiving treatment with infliximab by an on-demand strategy with or without MTX. In their post hoc analysis involving 34 patients receiving MTX and 42 patients not receiving MTX, infliximab concentrations were measured at weeks 2 and 6 after treatment. The authors found no significant difference in infliximab levels between the two groups. Our results are in agreement with these previously published results and provide a precise estimation of the drug exposure with repeated and prolonged measurement of infliximab.
We found no difference between treatment groups with regard to change in BASDAI scores or ASAS 20 criteria, findings which are in agreement with results from previous controlled trials [3–5]. Although clinical outcome was not our objective, our results do not argue for a clinical benefit of adding MTX to infliximab treatment (5 mg/kg/infusion) for AS with predominantly axial symptoms. Patients who were responders at week 18 showed a rapid decrease in BASDAI scores, which suggests that an early decrease in BASDAI score may predict a response later on. By contrast, a patient who has not responded at 6 weeks after initiation seems likely to be a primary nonresponder.
The MTX dosage we used, 10 mg/week orally, was in agreement with the recommendation by an expert opinion of a broad international panel of rheumatologists [15]. A subcutaneous route or higher dosage than 10 mg/week would not likely have changed our results, because a previous study found no clinical response in patients with AS receiving MTX 15 to 20 mg/week subcutaneously [2].
We observed an important variability in infliximab exposure in both groups of patients. This variability has been reported in previous studies in which trough concentration was measured [14, 16]. Our study provides a more precise characterisation of this variability and confirms that exposure to treatment differs considerably among individuals.
We found that one patient was positive for ATI. Of note, this patient did not receive MTX, and this finding raises the question of the hypothetical role of immunosuppressive agents in preventing immunisation as reported in rheumatoid arthritis (RA) and Crohn's disease [17–19]. Because of the small number of participants and the relatively short duration of the study, no conclusion can be drawn regarding the potential role of MTX in reducing immunogenicity in AS.
Our results differ from those of Maini et al. [17], who found that MTX increased infliximab concentrations in RA. In RA, disease activity at baseline was found to be negatively associated with infliximab trough concentration at 6 weeks after initiation of treatment [20, 21]. This phenomenon may be explained by targeted mediated-drug disposition and high levels of TNF-α (which corresponds to antigenic burden) binding infliximab, which influence its pharmacokinetics. MTX is effective as monotherapy in patients with RA by decreasing TNF-α levels, which in turn increase infliximab concentrations [17]. That MTX did not improve infliximab exposure in our study patients with AS who had predominantly axial symptoms may reflect the fact that TNF-α antigenic burden is lower in AS than in RA.
MTX seems to have no significant effect on infliximab pharmacokinetics in AS with predominantly axial symptoms. These results do not argue for adding MTX to infliximab therapy in this condition.
ankylosing spondylitis
Assessment in Ankylosing Spondylitis 20% improvement criteria
antibody toward infliximab
area under the concentration versus time curve
Bath Ankylosing Spondylitis Disease Activity Index
enzyme-linked immunosorbent assay
nonsteroidal anti-inflammatory drug
rheumatoid arthritis
- TNF-α:
tumour necrosis factor α.
The authors thank Nelly Jaccaz-Vallée, Sergine Gosset, Hélène Bansard, Fanny Teasdale and Elisabeth Jeannet for blood sampling; Anne-Claire Duveau for technical assistance in infliximab concentration and antibody toward infliximab measurements; Wiebe De Jong for technical support with the study protocol and data management; and Laura Heraty for her kind assistance with the manuscript. The University Hospital of Tours, France, received funding from the French Ministry of Health and Sport for this clinical trial within the framework of the 'Programme Hospitalier de Recherche Clinique 2004'.
Authors' Affiliations
- van der Heijde D, Dijkmans B, Geusens P, Sieper J, DeWoody K, Williamson P, Braun J: Efficacy and safety of infliximab in patients with ankylosing spondylitis: results of a randomized, placebo-controlled trial (ASSERT). Arthritis Rheum. 2005, 52: 582-591. 10.1002/art.20852.View ArticlePubMedGoogle Scholar
- Haibel H, Brandt HC, Song IH, Brandt A, Listing J, Rudwaleit M, Sieper J: No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Ann Rheum Dis. 2007, 66: 419-421. 10.1136/ard.2006.054098.PubMed CentralView ArticlePubMedGoogle Scholar
- Altan L, Bingol U, Karakoc Y, Aydiner S, Yurtkuran M, Yurtkuran M: Clinical investigation of methotrexate in the treatment of ankylosing spondylitis. Scand J Rheumatol. 2001, 30: 255-259. 10.1080/030097401753180318.View ArticlePubMedGoogle Scholar
- Gonzalez-Lopez L, Garcia-Gonzalez A, Vazquez-Del-Mercado M, Muñoz-Valle JF, Gamez-Nava JI: Efficacy of methotrexate in ankylosing spondylitis: a randomized, double blind, placebo controlled trial. J Rheumatol. 2004, 31: 1568-1574.PubMedGoogle Scholar
- Roychowdhury B, Bintley-Bagot S, Bulgen DY, Thompson RN, Tunn EJ, Moots RJ: Is methotrexate effective in ankylosing spondylitis?. Rheumatology (Oxford). 2002, 41: 1330-1332. 10.1093/rheumatology/41.11.1330.View ArticleGoogle Scholar
- Chen J, Liu C, Lin J: Methotrexate for ankylosing spondylitis. Cochrane Database Syst Rev. 2006, 4: CD004524-PubMedGoogle Scholar
- Pérez-Guijo VC, Cravo AR, Castro Mdel C, Font P, Muñoz-Gomariz E, Collantes-Estevez E: Increased efficacy of infliximab associated with methotrexate in ankylosing spondylitis. Joint Bone Spine. 2007, 74: 254-258. 10.1016/j.jbspin.2006.08.005.View ArticlePubMedGoogle Scholar
- Breban M, Ravaud P, Claudepierre P, Baron G, Henry YD, Hudry C, Euller-Ziegler L, Pham T, Solau-Gervais E, Chary-Valckenaere I, Marcelli C, Perdriger A, Le Loët X, Wendling D, Fautrel B, Fournié B, Combe B, Gaudin P, Jousse S, Mariette X, Baleydier A, Trape G, Dougados M, French Ankylosing Spondylitis Infliximab Network: Maintenance of infliximab treatment in ankylosing spondylitis: results of a one-year randomized controlled trial comparing systematic versus on-demand treatment. Arthritis Rheum. 2008, 58: 88-97. 10.1002/art.23167.View ArticlePubMedGoogle Scholar
- Pham T, Fautrel B, Dernis E, Goupille P, Guillemin F, Le Loët X, Ravaud P, Claudepierre P, Miceli-Richard C, de Bandt M, Breban M, Maillefert JF, Masson C, Saraux A, Schaeverbeke T, Wendling D, Mariette X, Combe B, Club Rhumatismes et Inflammation (CRI/SFR): Recommendations of the French Society for Rheumatology regarding TNFα antagonist therapy in patients with ankylosing spondylitis or psoriatic arthritis: 2007 update. Joint Bone Spine. 2007, 74: 638-646. 10.1016/j.jbspin.2007.10.003.View ArticlePubMedGoogle Scholar
- van der Linden S, Valkenburg HA, Cats A: Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum. 1984, 27: 361-368. 10.1002/art.1780270401.View ArticlePubMedGoogle Scholar
- Braun J, Pham T, Sieper J, Davis J, van der Linden S, Dougados M, van der Heijde D: International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis. Ann Rheum Dis. 2003, 62: 817-824. 10.1136/ard.62.9.817.PubMed CentralView ArticlePubMedGoogle Scholar
- Ternant D, Mulleman D, Degenne D, Willot S, Guillaumin JM, Watier H, Goupille P, Paintaud G: An enzyme-linked immunosorbent assay for therapeutic drug monitoring of infliximab. Ther Drug Monit. 2006, 28: 169-174. 10.1097/01.ftd.0000189901.08684.4b.View ArticlePubMedGoogle Scholar
- The R Project for Statistical Computing. [http://www.R-project.org/]
- Krzysiek R, Breban M, Ravaud P, Prejean MV, Wijdenes J, Roy C, Henry YD, Barbey C, Trappe G, Dougados M, Emilie D, French Ankylosing Spondylitis Infliximab Network: Circulating concentration of infliximab and response to treatment in ankylosing spondylitis: results from a randomized control study. Arthritis Rheum. 2009, 61: 569-576. 10.1002/art.24275.View ArticlePubMedGoogle Scholar
- Visser K, Katchamart W, Loza E, Martinez-Lopez JA, Salliot C, Trudeau J, Bombardier C, Carmona L, van der Heijde D, Bijlsma JW, Boumpas DT, Canhao H, Edwards CJ, Hamuryudan V, Kvien TK, Leeb BF, Martín-Mola EM, Mielants H, Müller-Ladner U, Murphy G, Østergaard M, Pereira IA, Ramos-Remus C, Valentini G, Zochling J, Dougados M: Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative. Ann Rheum Dis. 2009, 68: 1086-1093. 10.1136/ard.2008.094474.PubMed CentralView ArticlePubMedGoogle Scholar
- de Vries MK, Wolbink GJ, Stapel SO, de Vrieze H, van Denderen JC, Dijkmans BA, Aarden LA, van der Horst-Bruinsma IE: Decreased clinical response to infliximab in ankylosing spondylitis is correlated with anti-infliximab formation. Ann Rheum Dis. 2007, 66: 1252-1254. 10.1136/ard.2007.072397.PubMed CentralView ArticlePubMedGoogle Scholar
- Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, Macfarlane JD, Antoni C, Leeb B, Elliott MJ, Woody JN, Schaible TF, Feldmann M: Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor α monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum. 1998, 41: 1552-1563. 10.1002/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W.View ArticlePubMedGoogle Scholar
- Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P: Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet. 2002, 359: 1541-1549. 10.1016/S0140-6736(02)08512-4.View ArticlePubMedGoogle Scholar
- Baert F, Noman M, Vermeire S, Van Assche G, D' Haens G, Carbonez A, Rutgeerts P: Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med. 2003, 348: 601-608. 10.1056/NEJMoa020888.View ArticlePubMedGoogle Scholar
- Bendtzen K, Geborek P, Svenson M, Larsson L, Kapetanovic MC, Saxne T: Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab. Arthritis Rheum. 2006, 54: 3782-3789. 10.1002/art.22214.View ArticlePubMedGoogle Scholar
- Wolbink GJ, Voskuyl AE, Lems WF, de Groot E, Nurmohamed MT, Tak PP, Dijkmans BA, Aarden L: Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis. Ann Rheum Dis. 2005, 64: 704-707. 10.1136/ard.2004.030452.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Uncle John's Supremely Satisfying Bathroom Reader
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Come along to hear Nathan from Boost talk about the startup scene in Shanghai, how introducing Scrum has helped two young startups and why China should be on your startup radar!
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Great talks - very interesting
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- Material Choices: Metal Tubing
- Design Units: English
- Outside Diameter / Size: 0.7500 inch
- Maximum Inside Diameter / Size: 0.5890 inch
Description: up to 22 psi (1.5 bar). Appearance Clear Temperature:-66 to 135°C Life at 100 rpm:1000 hours Advantages:Ultra-smooth inner bore, excellent biocompatibility for sensitive applications, non-cytotoxic, non-pyrogenic, and non-hemolytic, low protein binding. Heat-sealable, bondable
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- Material Choices: Rubber / Silicone / Elastomer Tubing
- Maximum Inside Diameter / Size: 0.0598 inch
Supplier: SKS Science Products
Description: The clear vinyl laboratory tubing is non-toxic, transparent and inert. This smooth and flexible tubing is chemical resistant with a specific gravity of 1.2 and a tensile strength of 2000 psi. Our vinyl food grade tubing is designed for use in the laboratory with an elongation of 400% and excellent
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- Materials: Vinyl
Supplier: Xoxide
Description: ; Length: Sold by the Foot UV Reactive: Yes Anti-Microbial properties to keep your lines free of algae Smooth, low-friction inner bore Tack & print free outer surface (no ugly letters and numbers!)Show More
Description: to kinking render it highly suitable for fibre protection and management. Smooth bore. Bend limited to a controlled radius - 30mm. Crush protection. Polypropylene material. Tubing outer Diameter: 5.05mm . Minimum Cable Diameter:2.6mm Minimum Cable Diameter = 2.6mm Maximum Cable Diameter = 5.05mm Colour
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- Sleeving: Spiral Wrap
- Material: Other
- Diameter: 0.1024 to 0.1988 inch
- Length: 197 inch
Supplier: Qosina Corp.
Description: a strong adhesion to a biopharmaceutical tubing line reducing the need for ties. Barbed flanges feature a true bore design through the entire connector; the barb ensures a smooth transition from tubing to adaptor, which reduces turbulence. A slight raise at the port of the flange ensures proper
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- English Size: All English Sizes, Other English Size
- Metric Size: All Metric Sizes, Other Metric Size
- Material: Other
Description: Materials = Anodised Aluminium (Housing), PEEK/Stainless Steel (Gear), Polyacetal (Volute), Stainless Steel (Tubing Connector), Viton (Seal) IP Rating = IP67, IP68 Input Thread Standard or Connection Type = Bore Tube
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- Pump Type: Centrifugal Pumps
- Maximum Discharge Pressure: 145 psi
- Inlet Size: 0.1575 inch
- Power Source: 6 Volt DC, 12 Volt DC, 24 Volt DC, Other
Supplier: U.S. Tsubaki Power Transmission, LLC
Description: U.S. Tsubaki Chain Division has a variety of sprockets for the metal processing industries. Some operations, like pulling a sizing mandrel through tubing, create very high chain tension. This process can put significant stress on the sprockets. To keep your operation moving, you need sprockets
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- Material: Steel - Standard
- Sprocket Style: Single
- Shaft Mounting: Simple Bore
Description: Cole-Parmer offers a variety of barbed luer adapters to meet your application's needs. Choose from several different barb styles: * Standard hose barb for use with flexible tubing|* Smooth bore hose barb to reduce flow turbulence and risk of line contamination|* Wide-bore hose barb for enhanced
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- Connection Selection: Barb / Rib, Luer Lock
- Material: Other
Description: BioBarb hose tail to Tri-Clamp adaptors are produced from DMF listed polypropylene compliant with FDA and USP Class VI and European Pharmacopoeia. Lot numbers moulded in for full traceability Full through bore diameter ensures a smooth transition with no obstructions Identical internal diameter
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- Fitting Style: Cap/Plug
- English Size: All English Sizes, 1/2", 5/8", 3/4", 1", 1 1/4", 1 1/2"
- Connection Selection: Barb / Rib
- Material: Polypropylene (PP)
Supplier: Adelab Scientific
Description: steel modular columns use the exclusive Iso-Bore internal surface finish. This unique internal surface finish reduces drag at the column wall and improves column efficiency and performance by providing an extremely smooth, flat and clean surface. Twice as smooth (as measured by Ra, roughness averageShow More
Description: • Colored scale, Class A, PTFE<reg> stopcock plug • Capacity tolerance on these burettes is established by ASTM E-287 Burettes are calibrated in accordance with ASTM E-542. Tips are carefully drawn from accurate bore tubing to ensure proper drainage rates. Burettes have colored
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- Volume: 0.0066 gallons
Supplier: Value Plastics, Inc.
Description: No Description Provided
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- Category: Tube Fitting
- Fitting Style: Adapter
- English Size: All English Sizes, 1/8"
- Connection Selection: Barb / Rib, Luer Lock
Description: irradiation Full through bore diameter ensures a smooth transition with no obstructions Y junction splits the flow with minimum turbulence, optimising flow rate and back pressure Identical internal diameter of barb and tubing allows drainage along an unimpeded flow path Precision compression
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- Fitting Style: Wye
- English Size: All English Sizes, 1/4", 3/8", 1/2", 5/8", 3/4", 7/8", 1"
- Connection Selection: Barb / Rib
- Material: Polypropylene (PP)
Supplier: Parco Scientific Company
Description: contamination and to provide a precision fit within the barrel. The stopcock bores, body openings, and stems are carefully aligned for even liquid flow with fast cut-off. Made from Schott DURAN® borosilicate tubing with a low coefficient of expansion. Borosilicate tubing also provides uniform wallShow More
Description: The 114FDC OEM pumps offer a product range for continuous or intermittent applications. The pumps are reversible and are available as 12V DC and 24V DC with a choice of speeds. They are extremely easy-to-use and are compact and stylish. Small with a robust design Pumphead accepts seven bore sizes
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- Maximum Discharge Flow: 0.0111 to 2.69 GPH
- Inlet Size: 0.0197 to 0.1890 inch
- Discharge Size: 0.0197 to 0.1890 inch
- Power Source: DC Powered
Supplier: FasTest, Inc.
Description: micron) to 1000 psi Durable stainless steel snap rings, collets and springs Seals straight bore, step bore, smooth or cast surfaces For testing heat exchangers, pressure vessels, gauges, valves, and HVAC systems Safety design feature prevents accidental disconnect under pressure Durable neoprene
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- Connection Method: Lever
- Sealing Method: Internal
- Connection Size: 1.25 inch
- Pressure Rating: 750 psi
Supplier: FasTest, Inc.
Description: micron) to 1000 psi Durable stainless steel snap rings, collets and springs Seals straight bore, step bore, smooth or cast surfaces For testing heat exchangers, pressure vessels, gauges, valves, and HVAC systems Safety design feature prevents accidental disconnect under pressure Durable neoprene
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- Connection Method: Lever
- Sealing Method: Internal
- Connection Size: 0.8750 inch
- Pressure Rating: 1000 psi
Supplier: Milacron LLC
Description: , an exceptionally competitive value to our customers...from stand-alone extruders to complete systems. Smooth bore (PAK) to grooved feed (G-PAK). Floor mounted (S-PAK) or pedestal mounted (S-PAK-T) coextruder models available from 3/4" to 1-3/4". The PAK series single screw extruders handle
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- Machine Type: Plastic Extrusion Machine
- Screw Rotation: Single Screw
Supplier: Control Company
Description: of tubing, and the depth of vials. Depth bar extends from the end of caliper. Fine adjustment thumb roller improves reading speeds and position-holding lock screw sets length. Easy-to-read jumbo digital display is 1/3-inch-high. Traceable to NIST for accuracy No lubrication is ever required
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- General Gage Type: Internal Caliper
- Gaging Technology: Mechanical
- Units: English, Metric
- Display: Digital Display
Find Suppliers by Category Top
Featured Products Top
BRIM Electronics, Inc.
BCT Series of TFE FEP & Tefzel Convoluted Tubings
be cuffed and the tubing etched (run to order). BRIM MIL Spec extra flexible, helically convoluted tubings of TFE, FEP or Tefzel insulation provide all of the superior electrical and chemical capabilities of extruded smooth bore tubings, with greater flexibility. Helical convolutions allow a smaller bend radii than straight tubing. Protect wires and cables, gases and fluids, from harsh, impure or abrasive outside conditions with greater flaxibility. All convoluted tubings are manufactured from virgin... (read more)
Browse Tubing Datasheets for BRIM Electronics, Inc.
Qosina Corp.
Qosina Small Bore Connector, a Luer Alternative
Qosina now offers the SRC small bore connector from Colder Products Company (R) which eliminates the potential for misconnection with luer fittings. The intuitive design is simple to operate and has an audible "click " for added assurance of a secure, leak-free connection. Coupling body and coupling insert in-line hose barbs are available to fit tubing sizes 1/8 inch and 3/16 inch (3.2 mm to 4.8 mm) ID. Made from polypropylene and thermoplastic elastomer, the SRC connector can be EtO, e-beam... (read more)
Browse Quick Couplers Datasheets for Qosina Corp.
Stafford Manufacturing Corp.
Shaft Collars Won't Damage Structural Tubing
Shaft Collars Won 't Damage Structural Tubing. * Ideal for locating and mounting objects onto square and round structural tubing. * Smooth bores will not mar shafts or tubing. Stafford 's machined two-piece shaft collars are ideal for locating and mounting objects onto square and round structural tubing or for mounting tubing onto a wall, display, rack, conveyor, or machine. Stafford Shaft Collars for structural tubing feature a square or round bore and are sized to fit square or round tubing... (read more)
Browse Shaft Collars Datasheets for Stafford Manufacturing Corp.
Stafford Manufacturing Corp.
Wrenching Collars Prevent Crushing and Teeth Marks
PIPE AND SHAFT WRENCHING COLLARS. Collars feature wrenching flats and fit on six popular pipe sizes. Ideally suited for maintenance applications and for removing frozen pipes and tubing. Provide an easy way to turn shafts for alignment. Stafford 's line of smooth bore, two-piece collars feature wrenching flats and fit on six popular pipe sizes to facilitate installation and removal. Especially effective for removing frozen pipes and tubing, they let users apply torque using standard wrenches... (read more)
Browse Shaft Collars Datasheets for Stafford Manufacturing Corp.
Victrex plc.
used in the energy and industrial industries due to their ability to maintain durability in high-temperature, high-pressure, and corrosive operating conditions. In addition, the smooth inner bore of VICTREX Pipes allows for an ease of flow - a key benefit in the case of fluid transportation. For more information regarding VICTREX Pipes, please visit our website. (read more)
Browse Plastic Pipe Datasheets for Victrex plc.
Morris Coupling Company
General Purpose Metal Flexible Hose
Metal Flexible hose and Cutom-Fabricated Interlocked Hose Assemblies. A general purpose (unlined) or smooth bore (lined) metal flexible hose for dry-bulk material handling for pneumatic and vacuum systems. Flexible metal hose available in stainless, carbon or galvanized steel with end fittings assembled to customer specifications. Fabrications available with: Welded, brazed or epoxied connections. Wide variety of end fittings such as Ever-Tite couplers, flanges and stub ends. Sizes range from... (read more)
Browse Hose Fittings Datasheets for Morris Coupling Company
Numatics, Inc.
Numatics Knife Gate Valve Actuator
weeks while models with 12-inch and 14-inch bores are available in 3 to 4 weeks. The KG Series comes with ASCO Numatics' global reputation for quality. Its proprietary wear band improves cylinder life by locating piston load at the optimum point and providing maximum column strength at full extension. In addition, the actuator's popular composite tubing option significantly reduces overall cylinder weight for smoother operation and longer life. "The KG Series is the ideal choice for design... (read more)
Browse Datasheets for Numatics, Inc.
Haskel International LLC
How to expand heat exchanger tubes efficiently
and sets the tube into the tube sheet prior to HydroSwage® expansion. It is also used to set tubes prior to welding, and to flare boiler tubes. Water pressure from an air driven pumping system intensified to the desired high pressure. It is transmitted through a small bore, flexible high pressure tube to a lightweight hand-held mandrel holder. A mandrel, which latches into the mandrel holder, directs the pressure to the inside diameter of the tube ad is held within an accurately prescribed pressure... (read more)
Browse Tubing Datasheets for Haskel International LLC
General Pump
LHZ 6015 for ling life industrial duties
Rugged Application Pumps-LHZ 6015. Designed to meet the rigors of corrosive environments and on/off cycling these stainless steel pumps will do the job. This pump will handle up to 104 gpm and up to 1160 psi. (see specs). Compact Design. Smooth Running. Long Lasting. ISO 9001 Certified. These pumps feature a 316 Stainless Steel manifold and wetted parts for superior corrosion resistance and years of trouble free operation in aggressive environments. Owners Manual. General Pump, along with our... (read more)
Browse Water Pumps Datasheets for General Pump
Conduct Research Top
Medical Device Link . Spotlight on Tubing
A supplier of metal tubing and fabrication services stocks 304 and 316 stainless steel in diameters ranging from 0.23 to 5.16 mm and in various hardnesses and wall thicknesses. The firm can provide smooth-bore ID finishing. Capabilities include burr-free cutting and grinding, swaging, bending
Weighing the advantages of tubing versus pipe
bore, while a 1-in. tube has a nominal outside diameter of 1 in. Another advantage of tubing is that it can generally be installed faster than pipe. Tubing
Basics Of Design Engineering: Fluid Power
in diameters up to 2 in. with a variety of wall thicknesses and materials to meet the toughest application demands. It's important to note that tubing and pipe are sized differently. A 1-in. pipe, for instance, has a 1-in. nominal bore, while a 1-in. tube has a nominal outside diameter of 1 in. Another
More Information Top
Use of 15 mm tubing with the Humphrey ADE breathing system
All my published work on the Humphrey ADE system has been conducted using smooth bore tubing (Anaequip UK, Worthen, Shrewsbury, Shropshire) which has a relatively low resistance to flow, as flow through it is laminar; its diameter is more or less constant …
… form of d'upstream'' critical heat flux (CHF) has been observed and directly linkedto the inletflow pattern during an experimental study of high pressure (17 - 20 MPa) water flowing through a vertical 38.1 mm ID smooth bore tube with uniform axial and …
Eliminating pollution in paediatric and dental anaesthesia
15 mm smooth bore tubing is recommended for universal use.
[Hanford Atomic Products Operation monthly reports, January--December 1960]
Good progress is being made in the fabrication of the 200 Z_rcaloy-2 smooth bore tubes for C reactor scheduled for delivery by June 15.


text:
About Chad "LoganDX" G.
A bit on the nuts side about video games and movies but boy do I suck at FPS'. Love my Xbox but still crush some Playstation. Run the Sarcasm Marathon, fluent in it. Would kill for a decent Zelda movie.
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text: This Evening: Alex Ovechkin Parks His Car Like An AssholeDom Cosentino11/09/11 7:55pm181EditPromoteGo to permalink Your p.m. roundup for Nov. 9, the day the questions were a little too deep to ponder. Photo courtesy tstockd1, which was taken at the Kettler Capitals Iceplex in Arlington, Va. Got any stories or photos for us? Tip your editors.


text:
DragonVale Answers for iPhone - iPadHome / iPhone - iPad /
Game Questions & Answers (Q&A) service lets you ask questions about video games for game consoles or PC games. So ask your DragonVale question for iPhone - iPad and get answers from real gamers or answer questions and share your insights and experience with the rest of the gaming community.
- Developer: Backflip Studios
- Publisher: Backflip Studios
- Genre: Strategy Tycoon
- Release: Sep 14, 2011
- ESRB: Not Set
Question & Answers
How do i get a bone dragon?
I tried breeding a fire and earth dragon but i keep ending up with lava dragons. the same thing happens when i try to breed a quake dragon as well.
Answer from: deathbringer15
You need gems to get the bone dragon
Answer from: deathbringer15
To get free gems to get the bone dragon every day if you have a friend let him send you a preasent and get one gem for free or have a colloseum and get a gold medal to get 5 free gems
Answer from: Random
Try and breed an earth that is a higher level than a fire and a fire that is lower level.
earth on left fire on right!
same for the quake!
earth left stronger level, lightning right lower level!
to know if u got a quake dragon it should be in the breeding cave for 6:00h
Answer from: Kln
I keep getting the same results too, i saw on a different website to try lava and earth, but i havent tried it yet.
Answer from: APOLLOsCHILD
The earth and lava dosent work iv tried it three times i keep getting more lava dragons
Answer from: Charlie
I had some success breeding blazing on the left and earth on the right, both lvl 10. i got a bunch of lavas before it gave me bone, and the egg and incubation times were the same, so i didn't know until it hatched.
Answer from: Bren Bren
Breed lava dragon and earth dragon. had the same problem, but i started experimenting and just got my bone dragon earlier this morning.
Answer from: Nemesis
Tried breeding lava and earth for over a week now and repeat every 10 hours.. have 2 incubators to so i always have 2 eggs waiting to hatch and 1 breeding. so that's about at least 14 times this week now and i've always gotten lava -.-
past 2 days been trying fire and earth but getting same results.. it appears that it either doesn't work with lava/fire or more likly doesn't work with only earth + fire hybrid.. or that's it's a very low % drop.. just started trying 2 hybrids instead now.. currently have lava on left and quake on right.. will check back here tomorrow and add to thread if i have any success, wish me luck, i think i'll need it
Answer from: Daniel
Everything with earth and fire in it has a chance... same with blue fire and rainbow, got bluefire today after 4 tries lvl 10 fire with lvl 10 ice dragon gonna try bone now
Answer from: CGB006020
Ok,it isn't earth dragon or ice dragon or fire trust me it is.....lvl 10 lava and lvl 10 poison :)
Answer from: Prof titanic
Okay people. How to you get a firefly dragon? I do what is says in the market but I always end up with a scorch dragon.
Answer from: darkvoltz
All of you guys are just like me i kept on trying to breed lava and earth and i endid up with scorch then i tried brreding ranbow and earth same thing
Answer from: Invaderhaley
Omg i just did it and used obsidean and lava it worked the very first time i did it. Good luck guys
Answer from: wolflova
I dont have any of those how can i get one? plz help
Answer from: BlackMamba117
I used forge and iron and got it twice in a row. i dont now if its luck or not but it seems like a legit combination
DragonVale - Gameplay
- Added on: Aug 21, 2014
DragonVale - Gizmonauts Gameplay
- Added on: Aug 21, 2014
DragonVale - Breeding Guide Gameplay
- Added on: Aug 21, 2014
DragonVale - Update Review Gameplay
- Added on: Aug 21, 2014
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text:
John Locke (MP)
John Locke (1805 – 28 January 1880)[1] was an English barrister, author and Liberal Party politician.
The only son of John Locke, a surveyor of Herne Hill, he was educated at Dulwich College. Reading law at Trinity College, Cambridge, he left with an MA in 1832 and was called to the Bar from the Inner Temple in 1833.[2]
Between 1845 and 1857 he was a common pleader of the City of London, and counsel to the Inland Revenue. He was elected as the Member of Parliament (MP) for Southwark at the general election in April 1857, and held the seat until his death.[3] He was mainly active in causes for the working class and local government, introducing a bill that give witnesses in criminal cases the right to affirm as in civil cases.
He died in February 1880 and was buried in the catacombs at West Norwood Cemetery.
Notes and references[edit]
- ^ Leigh Rayment's Historical List of MPs – Constituencies beginning with "S" (part 4)[self-published source][better source needed]
- ^ "Locke, John (LK824J)". A Cambridge Alumni Database. University of Cambridge.
- ^ Craig, F. W. S. (1989) [1977]. British parliamentary election results 1832–1885 (2nd ed.). Chichester: Parliamentary Research Services. pp. 16–17. ISBN 0-900178-26-4.
- Locke, John (1805–1880), J. A. Hamilton, rev. H. C. G. Matthew, Oxford Dictionary of National Biography
External links[edit]
- Hansard 1803–2005: contributions in Parliament by John Locke
|Parliament of the United Kingdom
|Preceded by
Apsley Pellatt
Sir Charles Napier
|Member of Parliament for Southwark
1857 – 1880
With: Sir Charles Napier to 1860
Austen Henry Layard 1860–1870
Marcus Beresford from 1870
|Succeeded by
Edward George Clarke
Marcus Beresford (1818–1890)
- 1805 births
- 1880 deaths
- Burials at West Norwood Cemetery
- Liberal Party (UK) MPs
- Members of the Parliament of the United Kingdom for English constituencies
- UK MPs 1857–59
- UK MPs 1859–65
- UK MPs 1865–68
- UK MPs 1868–74
- UK MPs 1874–80
- People educated at Dulwich College
- Alumni of Trinity College, Cambridge
- Members of the Inner Temple