text:
The Spurs have secured yet another title, adding further lore to the dynasty led by Gregg Popovich, Tim Duncan, Manu Ginobili and Tony Parker.
Continue reading "San Antonio Spurs Defeat Miami Heat to Win 2014 NBA Championship"
The Spurs have secured yet another title, adding further lore to the dynasty led by Gregg Popovich, Tim Duncan, Manu Ginobili and Tony Parker.
Continue reading "San Antonio Spurs Defeat Miami Heat to Win 2014 NBA Championship"
Starbucks will provide a free online college education to thousands of its workers, without requiring that they remain with the company, through an unusual arrangement with Arizona State University, the company and the university will announce on Monday. Continue reading "Starbucks to Provide Free Online College Education to Thousands of Employees"
At least four people have been killed in clashes in Benghazi between forces loyal to the former general Khalifa Haftar and fighters he has declared as "terrorists". Continue reading "Benghazi, Libya, Rocked by Fierce Fighting"
Some Portland residents will have another alternative for Internet service soon, as this week the Portland City Council has approved a franchise agreement with Google to bring its fiber service into the Northwest locale. Google will apparently offer free Internet service to Portland residents for a one-time $300 fee, a trade-off for the city dropping a three-percent fee levied on rival provider Comcast. Continue reading "Google Signs Deal with Portland Officials to Bring Fiber Internet Service to the City"
The FCC is continuing its aggressive course by wading into the fight between Netflix and internet service providers (ISPs) about what is causing slow internets. In recent weeks, Netflix has been (publicly) duking it out with Verizon through a campaign of direct shaming about the latter's alleged poor streaming speeds. Continue reading "FCC Gets Involved in Fight Between Netflix and ISPs"
A fast-moving fire ripped through a single-family home early Sunday, killing six people, including a boy on a Father's Day trip to Newark to honor his deceased dad, authorities and the boy's grandmother said. Continue reading "6 People Killed in House Fire in Newark, NJ"
A cannon fired by a Civil War re-enactment group at a parade in Utah sparked an explosion that sent three children to the hospital. Continue reading "3 Children Injured by Cannon Explosion During Civil War Re-enactment in Utah"
As Father's Day approaches, I recall that my father, Randall Keith Benjamin Sr., never sat my brothers and me down when we were kids and told us his entire life story. The memories that he shared with us about his childhood were more general summaries than detailed accounts. Continue reading "There's No Formula for Fatherhood – You Just Have to Be It"


text:
Canvas is Arts Council England's new digital video initiative. Launched in October 2015, it aims to bring new audiences into all artforms with regular video designed for digital platforms like YouTube, Facebook, Twitter and Instagram.
Engage a wider, more diverse online audience on and off YouTube and Facebook by being part of a powerful network.
Exposure to new revenue streams through ad-funded and sponsorship opportunities.
Dedicated budget to fund new Arts content for Canvas, focused on creative collaboration & emerging talent.
Access to the Canvas 'Playbooks' to unlock best practices. Dedicated Canvas audience development team and extended suite of Brave Bison tools to improve audience management.
Learn more about Canvas by reading our FAQ's
Login to

subset: commoncrawl


text:
Greetings Guest!!Dismiss Notice
In order to combat SPAM on the forums, all users are required to have a minimum of 2 posts before they can submit links in any post or thread.
RP - FIVE WEEKS - A WAKA story
Discussion in 'UO Siege Perilous' started by Yasou Wakayama, Jun 7, 2006.


text:
To get a gaming monitor that will never disappoint you it requires a bit of effort which to many include walking around manually or if you have diversified as many have, then you sit on your PC and surf for a couple of minutes for you to get your preferred brand. Whatever system you will decide to use, before you finally settle on a particular brand name, believe you me you must have come across one of these as your best 1440p monitor for gaming at one time:
1. ASUS PB278Q 27" LED Graphics Monitor
This has emerged as one of the best 1440p monitor for gaming that is at par with the Samsungs of this world. The technology behind this monitor is amazing. One could easily associate it with big names that have been in the market such as Samsung, LG, Sony and Panasonic. It though has its uniqueness that is never compared with any of the mentioned brands. Its panel comprises a 2.6 inch chassis. Besides, its color display and the variations are amazingly unique. It is also very reasonable in terms of the price. Though it does not support USB port, this does not deter you from enjoying all that you want to-gaming.
2. DELL U2713HM-IPS-LED 27" Monitor
DELL is known to be one of the leading companies in the world for the production of computers. The introduction of the DELL monitor puts it in the position of competing with others as one of the best 1440p monitor for gaming that you need to consider as you try and find you can use. The features' of this monitor include several customization features some of which are found nowhere in the gaming world. Perhaps what makes the monitor more desirable is the 3.0 USB port that is closely fitted in the monitor.
Its height adjustability and the swivel also make it look stunning among others in the market. The resolution for this monitor is at 2560 by 1440. This is incredibly high for a monitor like this. But this actually works for its advantage. Interestingly, the monitor comes with a 3-year Hardware Warranty. This should put you at rest especially if anything bad happened with the monitor's system.
3. QNIX QX2710 Evolution Led Monitor
This might not sound like a name that you are not familiar with in terms of electronics and especially when it comes to the best 1440p monitor for gaming. But be cautioned! This is a monitor worthy your meditation. First, the display can say much about what you are about to expect. It has one of the most over clocking gaming experiences there has been. What may surprise many is that inside the QNIX QX27 Evolution LED monitor lies the iconic PLS panel from Samsung. This means color performance can be likened with that of the Samsung monitors that have already made a name in the gaming industry.
You will get to enjoy a classy and rigid stand that is adjustable upon deciding to buy this monitor. It comes with one of the best price quotes among the gaming monitors. With its 5W+5W speakers that are in-built, be assured that your gaming will be transformed into a different level. Yes, you will get to enjoy your game every day if you take your time and analyze from this list of best 1440p monitor for gaming.


text: Studio 360 Edit this Published by Studio 360 Commentary: Seven Days in May Listen 4 min Queue Download this audio Want to embed this player? Use the code below. More info. <iframe frameborder="0" scrolling="no" height="130" width="100%" src="https://www.wnyc.org/widgets/ondemand_player/wnyc/#file=/audio/json/150534/&share=1"></iframe> Share on Facebook Share on Twitter Email a Friend Kurt considers some May milestones.


text:
Hi everyone,
Harry Abel and I are busy making labels for my hostas and we've come across
some names that our resources disagree on (Schmid's 'Genus Hosta'., Hosta
Finder, Robyn's Nest 1998, and Wade's catalogs. We'd appreciate hearing what
you all think the correct name is. Oh, and also the registrant (or
hybridizer/namer if not registered) and a year for either. We're not asking
much, huh??
kikutti var. kikutii f. leuconoto or kikutti ssp. leuconoto?
longissima longifolia or longissima var. longifolia?
nigrescens: which is right? Grenfell or Maekawa 37?
Piedmont Gold: which is it:F.H.Payne 82 or Piedmont Gardens 82, or Piedmont
Cindy Johnson/Harry Abel
making labels in White Bear Lake, MN
zone 4a
p.s. I'm sure more questions will arise as we get further in this project
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


text:
Charles R. Wood Park – The Festival Place, located in Lake George, New York. Image courtesy of the Lake George Chamber of Commerce. During the early months of 2007, Hemmings Motor News laid the groundwork to bring a world-class automotive event to northern New England. Far removed from a tr ... Read more
1969 Chevy Camaro SS396; image by the author. During this past weekend's 10th annual Hemmings Motor News Concours d'Elegance presented by Gullwing Motor Cars, the event staff announced the featured marques for its 11th annual three-day extravaganza, to be held on September 15-17, 2017, ... Read more
Book photos by Richard Lentinello. Back in the early-to-mid 1980s a small publishing company in northern New Jersey, well-known in muscle car circles, published a series of books called the Quicksilver Supercar Series. The publisher was muscle car enthusiast and public relations guru Martyn Schorr, ... Read more
"High Flyin' Moon Shot" by Mark Ervin. All images courtesy of Mark Ervin and Art-N-Motion. What might an animator's dream job be? To work for Pixar or Disney? Maybe Marvel? How 'bout getting to scribble away on the longest-running television show – animated or ot ... Read more
Photo courtesy Barrett-Jackson When noted collector Ron Pratte consigned his Tucker #1043 at this past weekend's Barrett-Jackson auction in Scottsdale, there was speculation that it could achieve a new world record for the famed make. Tucked within the auction company's 5000 Series, or ... Read more
Dudes! Time to pull your old stone-washed jean jacket out of the closet, grab your Bon Jovi cassettes and head on down to Spring Carlisle in time to watch Auctions America by RM run this third-gen 1983 Chevy Camaro convertible across their auction block at the Carlisle Expo Center (across the stree ... Read more
Joel Rosen, he of Baldwin-Motion fame, took delivery of the first of the new Motion Camaros that bear his name last weekend in Florida, the car's builder, Howard Tanner of Redline Motorsports in Schenectady, New York, told us. The car is a Motion Phase III 427 SC rated at 800hp, courtesy of a ... Read more
Let's say you were a twentysomething mullet-head just when Ronald Reagan was getting comfortable in the White House. You therefore have to remember the big kaboom that resulted when Chevrolet unveiled its third-generation Camaro. The aftermarket for body add-ons swelled to the proportions of ... Read more
The spring edition of the Charlotte AutoFair is right around the corner – April 7-10, to be exact – hosted by the Hornets Nest Region of the AACA and held on the sprawling grounds of Charlotte Motor Speedway located in Concord, North Carolina. If you plan on stopping in to partake in th ... Read more
Camaro-lovers eager to let their mullets flutter in the breeze got their first (wildly overpriced) tastes of the 2011 Camaro convertible this year: First at Barrett-Jackson when the rights to buy the second car to roll off the line were sold for $205,000; And then through reports of the 100 Neiman ... Read more


text:
Walmart offers the Igloo 4.5-Cubic Foot Refrigerator and Freezer in Black, model no. FR464, for $119 with free shipping. That's the lowest total price we could find by $16, excluding the below mention. Features include a door can holder, tall bottle shelf, slide-out shelving, and adjustable legs.
A close price: Home Depot has it for $122.57 with free shipping.
$119 free shippingShop Now


text:
1. This is Buffy Summers.
Don't worry, her name is silly for a reason. Because even girls with names that sound like they'd be at home running a sorority house can be huge badasses.
2. She's one of the most legendary female characters on TV. Ever.
She's flawed, and she's strong, and she's weak, and she's complicated. She's a person. Sometimes she cracks under the pressure. But she's got a job to do, and she gets it done.
3. She fights vampires. And demons. And other Big Bads.
She basically saves the world. A lot.
4. Her group of friends go by the nickname "The Scoobies."
Name inspired by the crime-fighting teens of Scoobie Doo. They also save the world a lot, but they've got algebra tests to worry about.
Willow's nerdy and cute. Cordelia's sarcastic and self-centered. Oz is wise and stoic. Xander's a Nice Guy™ and basically the Chandler of the group. Angel broods and gets a spin-off. Giles drinks tea and judges. Some stay as the years go by, some leave.
5. They live in Sunnydale, CA.
Sunnydale is a little town in Southern California that happens to be located on a Hellmouth. Hellmouths are as bad as they sound in that they're essentially evil's favorite hangout, which means there are a lot of demons/vampires/oogy-boogies for Buffy and her friends to fight in between homeroom and gym.
It's a town of under 40,000 and it's got twelve cemeteries. You do the math.
6. The show was based on a movie no one talks about.
Joss Whedon wrote it but didn't direct it, which resulted in a whole lot of changes he didn't like. No one really likes talking about it. Hillary Swank was in it. So was Donald Sutherland. Neither of them really like to talk about it, either.
7. The show has some of the most ambitious and interesting episodes in TV history.
No, really. This show was groundbreaking television in a lot of ways. A ton of academics have written about it. Joss Whedon and his team were terrified of getting stuck in story ruts, so they challenged themselves to do something interesting with their format whenever they could. This resulted in an episode modeled after a silent film (2/3rds of the episode is entirely without dialogue), one without music, and multiple episodes crafted entirely around dreams and foreshadowing. There's one plot point the writers foreshadowed two whole years before the actual plot was even introduced to the characters. Not to mention….
8. It practically invented the musical episode.
Once again, not exaggerating. Ever wonder where the trend of non-musical shows taking one episode out to prance around musically started? Right here. Joss Whedon noticed that certain members of the cast were musically talented, then wrote them an episode to show it off. It works within the conceit of the show, too: Why couldn't a world with magic and vampires and witches include a spell that makes the populace of a town burst into choreographed musical numbers? It happens.
9. People die.
Characters you love, characters you hate. I won't tell you who. But it happens. Prepare yourself.
10. In fact, things get pretty hard for every character at one point or another.
This is a show that will make you cry if you watch it right.
11. But the show will make you laugh, too.
Whedon & Co never let the tone get too dark without cracking a joke somewhere in there. You'll laugh just as often as you cry.
12. It also features the first lesbian relationship on network television.
It was kind of a big deal.
13. The show lasted 7 seasons, from 1997 to 2003.
And they're a pretty rocking seven seasons. And did we mention they're all on Netflix Instant Play?
14. So go forth, and watch Buffy!
And remember…
15. Don't ask who Dawn is.
Just don't. You'll get there.
16. The Cheese Man means nothing.
(We think.)
17. And always carry a stake. Always.
This post was created by a member of BuzzFeed Community, where anyone can post awesome lists and creations. Learn more or post your buzz!
- Caitlyn Jenner told President Trump that his administration's rollback of protections for transgender kids was a "disaster."
- Recreational marijuana needs "greater enforcement" of federal law, said Spicer, pitting the White House against eight states that legalized its use.
- A researcher with Human Rights Watch was denied entry into Israel after the country's government called the organization "propaganda."
- Beyoncé has pulled out of performing at Coachella, citing doctors' advice about keeping a less rigorous schedule while pregnant 🐝😭


text: OverviewBack to top Dr. Franks - Allergy Relief - 1 oz. Item# :61302UPC# :677867990616 Brand:Dr. Franks Size/Form:1 oz. Allergy Spray is for the relief of symptoms from indoor allergens (pets, dust, mites, and molds) and outdoor allergens (hay fever, pollens, etc.); relief of runny nose, sneezing, nasal or sinus congestion, post-nasal drip and itchy, watery eyes. Silent Snore Allergy Relief Spray is non-habit forming with no side effects.


text:
Accept. Respect. Include.SM
Gatepath has been "Turning Disabilities Into Possibilities" for more than 95 years.
We have one of the most comprehensive service portfolios spanning all ages from early intervention for infants to community access and job training for adults and seniors. All programs are designed to prepare children and adults to actively participate in their schools, community, workplaces and at home. Learn more
This December, we celebrated Electronic Arts's (EA) annual holiday party for Gatepath's children with special needs and their families. This time-honored tradition features one-on-one quiet time with Santa, where families can take as many pictures as they want in a sensory-friendly location ...


text:
BEACON Friday Seminars
Every Friday, we hold a seminar at 3:30 pm Eastern/2:30 pm Central/12:30 pm Pacific. Members at all five institutions participate via videoconference. All BEACON members are strongly encouraged to present their BEACON-funded or BEACON-related research and education projects at a Friday seminar!
Click here to view this schedule in Google Spreadsheets
2017 BEACON Congress
The dates have not yet been set for the 2017 BEACON Congress, but it will most likely take place in August at Michigan State University.


text:
Eley Kishimoto Two Scoops Wrapping Paper Sold in 25's
Eley Kishimoto
This product is currently sold out.
Product code: 2664
Tales of the House illustrated by Eley Kishimoto.
Printed on 100% recycled post consumer waste.
500mm x 700mm.
Please enter the multiple of 25 that you require into the quantity box.


text:
Arguments which are optional in DOM4 but not in our implementation:
Node.cloneNode(optional boolean deep); (Note, defaults to true)
Document.createNodeIterator(Node root, optional unsigned long whatToShow,
optional NodeFilter? filter);
Document.createTreeWalker(Node root, optional unsigned long whatToShow,
optional NodeFilter? filter);
The latter two methods used to take also bool aEntityReferenceExpansion as parameter.
We could perhaps make also that optional, or just leave it out.
I think we should just leave it out and make .expandEntityReferences return false.
(We should even make .expandEntityReferences warn if used and then remove it a release later. But that might be a separate bug)
Actually, we might even be able to remove .expandEntityReferences right away given that it's a property. So we won't throw if people use it, just return a falsy value (undefined).
Although the changes will be small, I'd prefer making them in separate patches/bugs so that if
some of them isn't web compatible, it can be easily backed out.
I figure that since I'm working on 698384 and 698385 I might as well go for this one as well, unless someone objects.
All three of the "sub tickets" 698381 698384 and 698385 are now resolved and have landed.


text:
115 Spalding Court UNIT 50,Statesville NC, 28677
Status: Active
Berkshire Hathaway HomeServices Carolinas Realty
(888) 778-2276
Last Updated: 2/24/2017 8:58 AM
Description for 115 Spalding Court UNIT 50 Statesville, NC 28677
Private wooded lot at 1.70 acres. Great location, close to 1-77 and I-40 with low Iredell County Taxes. Subdivision is adjacent to River Oaks Fairways Golf Club.Short commute to Lake Norman & Catawba River for full water activities and enjoyment.Seller has 4 Lots within Community, please inquire about addl Listings.Agent on Duty, Sat & Sun (1-4:00 PM) Southern Homes of The Carolinas; located on the lower level of River Oaks Golf & Country Club, 233 Broken Arrow Dr, Statesville NC 28677.
Listing Information
Augusta Greens
Holding Tank
School Information
Room Information
Exterior / Lot Features
Cul-De-Sac, Wooded
Inside AccessTM
Current market conditions for 115 Spalding Court UNIT 50
Active Market Trends
Source:MLS DATA
Median list price$178,990
Days on market131
Properties for sale255
Sold Market Trends
Source:MLS DATA
Median sold price$145,000
Sales to list price9,664.0%
Properties sold205
Median sq ft price$79
Arrows indicate 90 day trend
Listing Price History for 115 Spalding Court UNIT 50
Statesville Real Estate
Statesville is located in North Carolina. Statesville, North Carolina 28677 has a population of 24,803.
The median household income in Statesville, North Carolina 28677 is $33,998. The median household income for the surrounding county is $50,058 compared to the national median of $53,046. The median age of people living in Statesville 28677 is 38 years.
Loading nearby sales and history ...
Ask a Question?
Berkshire Hathaway HomeServices Carolinas Realty
(888) 778-2276
Start a no spam email conversation
My Drive Time
Enter your work address to view actual drive times with traffic for this property
Here is the weekday INRIX Drive Time from this property to .
When you register, you will receive ...
Weekday drive times
Plus all these great features
Register or login today to take advantage of Drive Time
Nearby homes for sale
Inside AccessTM
Statesville Real Estate
Nearby Communities


text:
>Hello ,
Over the weekend I visited the Great Orme at Llandudno .In the
visitors center were some pictures including one of a Geranium indigenous
to the 'Great Orme' .
Unfortunately the shop [info center ] was closed and the caption under the
photo read 'Bloody Cranesbill' .
Do any of you have any idea of the plants name ?
Best Wishes


text:
This is the January 16, 2013 news archive. View today's Heat rumors and news.
Miami Heat
Miami Heat News and Rumors
Warriors' Curry sprains ankle, sits against Heat
ESPN.com Updated Jan 16, 2013
Golden State Warriors point guard Stephen Curry will not play against the Miami Heat on Wednesday night after spraining his twice surgically repaired right ankle.Share Tweet
Pat Riley with Heat for final two games of road trip; Wade's strange message on Twittermiamiherald.com Jan 16, 2013OAKLAND - Amid the Heat's losing skid, which included the benching of Dwyane Wade on Monday, Heat President Pat Riley arrived in the Bay Area on Tuesday and attended the Heat's Wednesday morning shootaround at the University of San Francisco. Despite thShare Tweet
Lakers' Gasol to return for matchup with HeatPau Gasol has spent far too much of the past 10 days in dark rooms with no distractions. He's eager to get back under the NBA's bright lights as the Los Angeles Lakers try to get it together in time for a playoff run.Share Tweet
Daily Dime: Heat rule when interestedESPN.com Jan 16, 2013LeBron James' milestone night showed a team engaged and at its best, Brian Windhorst writes.Share Tweet
Dwyane Wade wears 'Cat in the Hat' socks to Miami Heat practice (PHOTO)yahoo.com Jan 16, 2013Back in August, before he had ever played an NBA game, Golden State Warriors rookie Harrison Barnes appeared before schoolchildren in Ames, Iowa decked out in full 'Cat in the Hat' garb. It was cool, it was creepy, and it was a cool offseason diversion …Share Tweet
Dwyane Wade says he has no ill feelings toward coach Erik SpoelstraESPN.com Jan 16, 2013Miami Heat star Dwyane Wade said Wednesday he has no ill will toward coach Erik Spoelstra over his benching in the fourth quarter of Monday's loss to the Utah Jazz.Share Tweet
Dwayne Wade says he has no ill feelings toward coach Erik SpoelstraMiami Heat star Dwyane Wade said Wednesday he has no ill will toward coach Erik Spoelstra over his benching in the fourth quarter of Monday's loss to the Utah Jazz.Share Tweet
Wade Alley-oop To LeBronJan 16Dwyane Wade alley-oop to LeBron James who finishes with the dunk.
LeBron's 5,000th AssistJan 16LeBron James finds Dwyane Wade for his 5,000th career assist.
LeBron Greatest Scorer In History Of NBA?Jan 16The NBA Countdown crew comparing LeBron James with the greatest scorers of all-time in the NBA.
THTV: Stephen CurryJan 16Golden State guard Steph Curry says the Warriors are for real, discusses the W's surprising defense and talks about what an All-Star selection would mean to him and the team.


text:
WHO Visits Saudi Arabia to Investigate Coronavirus CasesJason Gale and Kristen Hallam
Two World Health Organization employees travelled to Saudi Arabia on May 8 to meet with local health officials on the novel coronavirus, after an outbreak at a hospital there.
The WHO trip was in addition to a visit by international scientists who were invited by the country, Gregory Hartl, a WHO spokesman, said in an e-mailed statement today.
"The purpose of the WHO mission is to better understand the situation and to provide guidance," Hartl said. "The WHO team may meet with some of the international scientists, but will primarily hold discussions with the Ministry of Health."
Saudi Arabia reported two more confirmed cases of the virus, in a 48-year-old man and a 58-year-old man, bringing the total number of cases in the country to 15, the Geneva-based WHO said yesterday. Both patients are linked to an outbreak this month in a health-care facility, and Saudi officials are investigating, the health agency said. Thirty-three people worldwide are known to have been sickened by the virus since September, and 18 of them have died, the WHO said.
There hasn't been any evidence yet of sustained transmission of the new coronavirus, Hartl said. Limited human-to-human infection probably occurred previously in Saudi Arabia as well as in the U.K., where three members of a family were diagnosed with the illness in February.
Limited Transmission
"We know of at least two instances -- a previous event in Saudi Arabia and the event in the U.K. -- where there was likely limited human-to-human transmission, but as of this moment there has not been any sustained, community-level spread," he said. "What we know today may not apply tomorrow, as this is a rapidly evolving event."
France reported its first confirmed case of the infection this week. The patient had traveled to the Middle East, where the first cases of the virus were reported last year, according to the World Health Organization. Her roommate, doctor and a nurse have been hospitalized for tests in Valenciennes, in northern France, France Info reported on its website.
Coronaviruses are a family of pathogens that cause illnesses ranging from the common cold to Severe Acute Respiratory Syndrome, or SARS, which sickened more than 8,000 people and killed 774 in 2002 and 2003, according to the WHO. While the new virus is related to the one that causes SARS, it appears far less transmissible, the WHO has said.


text:
Multiple sclerosis lesion activity concurs with the extent of inflammation, demyelination and axonal suffering. Pro-inflammatory myeloid cells contribute to lesion development, but the self-limiting nature of lesions implies as yet unidentified anti-inflammatory mechanisms. We addressed the hypothesis that myelin ingestion by myeloid cells induces a foamy appearance and confers anti-inflammatory function. First, we show that myelin-containing foam cells in multiple sclerosis lesions consistently express a series of anti-inflammatory molecules while lacking pro-inflammatory cytokines. Second, unique location-dependent cytokine and membrane receptor expression profiles imply functional specialization allowing for differential responses to micro-environmental cues. A novel human in vitro model of foamy macrophages functionally confirmed that myelin ingestion induces an anti-inflammatory programme. Foamy macrophages are unable to respond to prototypical inflammatory stimuli but do express molecules involved in suppression of inflammation. These findings provide novel insights into the mechanisms of lesion control and may open new roads to intervention.
Multiple sclerosis is a chronic inflammatory autoimmune disease of the CNS and is characterized by the presence of demyelinated areas throughout the CNS (Sospedra and Martin, 2005). Various mechanisms leading to demyelination and axonal suffering have been implicated and the production of toxic inflammatory mediators by infiltrating and resident CNS macrophages is believed to play a pivotal role (Raine, 1994; Becher et al., 2000; Wingerchuk et al., 2001; Cannella and Raine, 2004; Lassmann, 2004; Matute and Perez-Cerda, 2005; Sospedra and Martin, 2005).
Different subsets of myeloid cells have distinct roles in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. These distinct and specialized roles of myeloid cells depend on their origin and, importantly, their location (Greter et al., 2005; Heppner et al., 2005; McMahon et al., 2005; Platten and Steinman, 2005). As such, perivascular cells appear to be optimally positioned for the modulation of infiltrating T cell activity whereas parenchymal myeloid cells may have a more prominent role in mechanisms involved in myelin breakdown and axonal suffering (Platten and Steinman, 2005).
The plasticity and functional polarization of macrophages have received renewed attention in the light of novel key properties of different forms of macrophages. Two extremes of a continuum have been identified for macrophages, being M1, or classically activated macrophages and M2, or alternatively activated macrophages (Mantovani et al., 2002; Gordon, 2003; Mosser, 2003; Mantovani et al., 2004). The M1 phenotype is typically induced in vitro by IFN-γ, TNF-α or LPS, whereas the M2 phenotype can be induced by IL-10, IL-4 or by the lipid mediator PGE2, which is a strong inhibitor of pro-inflammatory immune responses (Kalinski et al., 1997; Hinz et al., 2000; Gratchev et al., 2001; Ikegami et al., 2001; Harris et al., 2002). M1 macrophages are characterized by a high production of pro-inflammatory mediators and are involved in Th1 cell responses and the killing of micro-organisms and tumour cells. In contrast, M2 macrophages are associated with Th2 responses, scavenging of debris, promotion of tissue remodelling and repair and expression of anti-inflammatory molecules, including IL-1ra (IL-1 receptor antagonist) and CCL18 (Gordon, 2003; Mantovani et al., 2004). CCL18 in particular is a specific marker for human alternatively activated macrophages (Kodelja et al., 1998; Goerdt et al., 1999; Mantovani et al., 2002; Gordon, 2003) and is involved in immune suppression (Gordon, 2003; Vulcano et al., 2003). In contrast to in vitro studies, the M2 phenotype in vivo is more variable. An M2-like phenotype can be observed in various other situations, including helminth infection, cancer, Gaucher disease and in healthy lung tissue (Mantovani et al., 2002; Boven et al., 2004; Herbert et al., 2004; Beharka et al., 2005). However, variations in expression profiles of M2-markers are observed depending on specific cues. It seems likely that the different phenotypes result from different cues leading to the M2-like phenotype (e.g. different cytokine milieu, parasite phagocytosis, lipid accumulation, surfactant ingestion) enabling the cell to respond to and deal with the specific stimulus in an appropriate way.
Demyelinating multiple sclerosis lesions are characterized by the presence of foamy macrophages, a characteristic subset of myeloid cells, which acquire their distinctive morphology by ingestion and accumulation of vast amounts of myelin-derived lipids. Foamy macrophages originate from both resident microglia and infiltrating monocytes (Li et al., 1996). Besides their apparent role in scavenging myelin, it is still poorly understood if and how foamy macrophages may affect the local inflammatory process. Since multiple sclerosis lesions are self-limiting and do not expand indefinitely it is likely that local mechanisms restrict CNS inflammation and may also promote tissue repair. We hypothesized that foamy macrophages are anti-inflammatory M2-type macrophages and actively contribute to the resolution of brain inflammation. Our findings reveal an important and previously overlooked anti-inflammatory role for foamy macrophages in multiple sclerosis lesions.
Material and methods
Immunohistochemical analysis of post-mortem multiple sclerosis brain tissue
Human autopsy brain tissue from 5 multiple sclerosis patients was provided by the Netherlands Brain Bank in Amsterdam (Coordinator Dr R. Ravid). Immunohistochemistry was performed on frozen sections of multiple sclerosis brain tissue to detect expression of (anti-)inflammatory markers and CNS antigens as described previously (Hoefakker et al., 1995). In brief, 6 µm frozen sections were cut and thawed on to glass slides. Slides were kept overnight at room temperature in humidified atmosphere. After air-drying, slides were fixed in acetone containing 0.02% (v/v) H2O2. Slides were then air-dried for 10 min, washed with PBS and incubated with optimally diluted primary antibody overnight at 4°C in humidified atmosphere. Incubations with secondary rabbit anti-mouse-Ig-biotin (Dako) and tertiary horseradish peroxidase (HRP)-labelled avidin–biotin complex (ABC/HRP: Dako) were performed for 1 h at RT. HRP activity was revealed by incubation for 10 min at RT with 3-amino-9-ethyl-carbazole (AEC: Sigma), leading to a bright red precipitate. After washing, sections were counterstained with haematoxylin and embedded with glycerol-gelatin. Omission of primary antibody acted as control staining. Myelin degradation products were detected with oil-red O (ORO), which stains neutral lipids, as previously described (Chayen and Bitensky, 1991). The antibodies used were directed against IL-1ra (Biosource), IL-4 (U-Cytech), PGES (Cayman), TGF-beta (Santa Cruz) and CCL18 (R&D) as anti-inflammatory markers; HLA class II (Dako), CD163 (gift from Prof. C.D. Dijkstra), mannose receptor (gift from Dr F. Noorman), CD11b (BD Biosciences) for antigen recognition and presentation; IL-1β (gift from Dr Boraschi), TNF-α (U-Cytech), IL-6 (Genzyme), IL-12p40/p70 (Pharmingen); for CNS proteins MOG, MAP-2 (Pierce) as pro-inflammatory markers.
In vitro model for myelin-driven foam cell formation
Myelin was isolated as described previously (Norton and Poduslo, 1973). In short, white matter derived from post-mortem brain tissue (gift from Dr Hans van Noort) was homogenized in 0.32 M sucrose and subsequently layered on 0.85 M sucrose. After centrifugation at 75 000 g myelin was collected from the interface, washed in water and suspended in water for osmotic shock. Using this method, the purified myelin was shown to be free of any recognizable fragments of other subcellular elements. Previous studies have shown that purified myelin structurally resembled the whole myelin as seen in tissue sections using electron microscopy (Autilio et al., 1964).
Peripheral blood mononuclear cells were isolated from heparinized blood from healthy donors using a Ficoll density gradient. Subsequently, monocytes were purified using Percoll density gradient resulting in >80% monocytes. Monocytes were cultured in suspension at a concentration of 1 × 106 cells/ml in Teflon flasks (Nalgene) in RPMI with 5% human AB serum. After 5–7 days monocyte-derived macrophages were recovered from the Teflon flasks and seeded in tissue culture plates. After 24 h non-adherent cells were removed and remaining cells were >95% macrophages as determined by macrophage-specific esterase staining. Foamy macrophages were generated in vitro by incubating macrophages with myelin for 24 h-7 days (referred to as 1 day and 7 day-old foamy macrophages). For experiments shown in Fig. 5A the indicated concentrations of myelin were used, for all subsequent experiments 50 µg/ml myelin was used. Control macrophages were obtained from the same donor and not fed with myelin.
To determine cytokine production in culture supernatants of foamy macrophages commercial capture ELISA was performed. TNF-α, IL-10 and IL-12p40 were measured in the collected culture supernatants. ELISA was performed according to the manufacturers' guidelines (Biosource). Briefly, polystyrene microtitre wells (Immuno Maxisorp) were coated overnight at 4°C with monoclonal anti-cytokine capture antibodies. Wells were blocked for 2 h at RT with PBS/0.5% BSA, followed by washing (0.9% NaCl/0.1% Tween-20). Freshly thawed supernatants of the cell cultures and recombinant human cytokine-standards were incubated in duplicates for 2 h at RT in the presence of a biotinylated second anti-cytokine detection antibody. After washing, wells were incubated with HRP-labelled poly-streptavidin (CLB) for 30 min at RT. HRP revelation was performed with 3,3′,5,5′-tetramethylbenzidine (TMB) peroxidase (KPL). Colour development was stopped by adding equal volume of 1 M H2SO4. Optical density was measured at 450 nm.
CCL18 levels were measured by sandwich ELISA assay using a commercially available CytoSet (Biosource), consisting of a capture-antibody, a biotinylated detection antibody, recombinant CCL18 standard and streptavidin-HRP conjugate. Assay conditions were exactly as described by the manufacturer.
Real-time quantitative PCR
To quantify mRNA expression by foamy macrophages total RNA was extracted from cell cultures using the GenElute Mammalian Total RNA kit (Sigma). RNA samples were treated with DNAse I (Invitrogen) to remove any contaminating DNA. Using 1 µg of the total RNA as template, copy DNA (cDNA) was prepared using the AMV Reverse Transcription System (Promega). To determine target gene mRNA expression, real-time quantitative reverse-transcription-PCR was performed using TaqMan technology (PE-Applied Biosystems) as described previously (van der Fits et al., 2003). Target gene expression levels were corrected for GAPDH mRNA levels. Sequences of the PCR primers (PE Biosystems) and fluorogenic probes (Eurogentec or Roche) are: forward primer 5′-CCTTCCTCCTGTGCCTGATG, reverse primer 5′-ACAATCTCATTTGAATCAGGAA, probe 5′-TGCCCGACTCCCTTGGGTGTCA for COX-2; forward primer 5′-ACGGCGCTGTCATCGATT, reverse primer 5′-GGCATTCTTCACCTGCTCCA, probe 5′-CTTCCCTGTGAAAACAAGAGCAAGGCC (Eurogentec) for IL-10; forward primer 5′-GCCCAGGCAGTCAGATCATC, reverse primer 5′-GGGTTTGCTACAACATGGGCT, probe 5′-CTCGAACCCCGAGTGACAAGCCTG (Eurogentec) for TNF-α; forward primer 5′-CACCGGAACGACATGGAGA, reverse primer 5′-TCCAGGCGACAAAAGGGTTA, probe 5′-TGGGCTTCGTCTACTCCTTTCTGGGTC (Eurogentec) for PGES; forward primer 5′GCCTGGCCTCCAGAAAGACC, reverse primer 5′-ACCTGGTACATCTTCAAGTCTTCATAAAT, probe 5′-CTTTTATGATGGCCCTGTGCCTTAGT (Eurogentec) for IL-12p35; forward primer 5′-GTTCCCCATATCCAGTGTGG, reverse primer 5′-TCCTTTGCAAGCAGAACTGA, probe TGGCTGTG (Roche) for IL-23p19; forward primer 5′-GCCATATGGGAACTGAAGAAA, reverse primer 5′-GGGGTGTCACAGGTGAGG, probe CCTGGAGA (Roche) for IL-12/23p40; forward primer 5′-GCCAGGAGTTGTGAGTTTCCA, reverse primer 5′-TGCAAGGCCCTTCATGATG, probe 5′-TCTGACCACTTCTCTGCCTGCCCA for CCL18.
Statistical analysis
Statistical analysis was performed using the non-parametric Mann–Whitney analysis. P-values < 0.05 were considered significant.
Foamy macrophages express anti-inflammatory markers and demonstrate a unique location-dependent phenotype
To determine the immune phenotype of lipid-laden foamy macrophages in multiple sclerosis lesions, we used antibodies against CNS proteins, various surface markers involved in antigen recognition and presentation and pro- and anti-inflammatory markers characteristic for M1 and M2 macrophages (Kodelja et al., 1998; Goerdt et al., 1999; Mantovani et al., 2002; Gordon, 2003). Figure 1 shows a typical multiple sclerosis lesion with a clear loss of myelin as demonstrated by myelin oligodendrocyte protein (MOG) staining (Fig. 1A). Foamy macrophages were defined by their characteristic morphology, strong HLA-DR expression and the presence of neutral lipids, which are detected by oil-red O histochemistry (ORO, Fig. 1B and C). To determine whether foamy macrophages display phenotypic and functional specialization dependent on micro-location, we analysed the phenotype of these cells in different micro-locations (Fig. 1D). Thus, we distinguished between foamy macrophages within the lesion, in perivascular spaces within the lesion and in the outer or inner rim (Fig. 1D). The distinction between the outer and inner rim was based on the presence of neutral lipids, MOG and on the size of the foamy macrophages. Outer rim foamy macrophages were smaller in size and contained more MOG, but less neutral lipids than inner rim foamy macrophages.
IL-6, a cytokine with pro- as well as anti-inflammatory properties as well as the anti-inflammatory M2 marker IL-1ra and prostaglandin E2 synthase (PGES) were differentially expressed in the distinct areas of the lesion (Fig. 2A–C). Whereas IL-6 and IL-1ra were detected mostly in perivascular and lesional foamy macrophages, PGES was mostly expressed in the outer and to a lesser extent in the inner rim. Importantly, expression patterns between cells varied even when cells were in close proximity. Mannose receptor, which is characteristic for M2 macrophages (Mantovani et al., 2002, 2004; Gordon, 2003; Mosser, 2003), was highly expressed on foamy macrophages in perivascular spaces (Fig. 2D, arrows) but was mostly absent on parenchymal foamy macrophages (Fig. 2D, arrowheads). Occasionally, a weakly positive cell was observed (Fig. 2D, asterisk) which was always in the vicinity of a blood vessel. TGF-β expression showed the reverse expression pattern with more pronounced expression by parenchymal foamy macrophages compared to perivascular foamy macrophages (Fig. 2E, arrowheads and arrows, respectively).
As hypothesized, the relative levels of expression were related to specific micro-locations within the lesion (Fig. 3). Foamy macrophages in the lesion rim contained MOG and immunoreactivity showed a decreasing trend towards the centre of the lesion, possibly reflecting time-dependent myelin degradation. In contrast, intracellular neuronal antigen MAP-2 immunoreactivity increased towards the centre of the lesion, implicating that neuronal damage occurs mostly in the lesion centre. Only foamy macrophages within perivascular spaces expressed the surface markers CD11b, CD163 and mannose receptor (Fig. 3). The anti-inflammatory molecules IL-1ra, CCL18, IL-10, TGF-β and IL-4 were all expressed by foamy macrophages and expression was highest in the centre of the lesion (Fig. 3). Interestingly, IL-10 expression was not found in foamy macrophages in perivascular spaces. The pro-inflammatory cytokines TNF-α, IL-1β, IL-12p40/70 were not expressed by foamy macrophages in any of the micro-locations (Fig. 3), whereas cells associated with vessels in normal appearing white matter (NAWM) did express these pro-inflammatory cytokines. Phenotypic heterogeneity was not observed among non-foamy macrophages which were present in low numbers in perivascular spaces in NAWM. These non-foamy macrophages all expressed markers such as CD11b and CD68 and did not produce the typical anti-inflammatory molecules as observed for the foamy macrophages.
Thus, we demonstrate that foamy macrophages in the brain have clear anti-inflammatory characteristics, resemble M2 macrophages and have a unique phenotype depending on the micro-location.
Myelin induces a foamy morphology in macrophages resembling that of foamy macrophages in situ
Next, we set out to determine whether ingestion of myelin in vitro results in an anti-inflammatory function of foamy macrophages as observed in situ. Therefore, we first developed a fully human in vitro model of foamy macrophages. Human primary macrophages obtained from healthy donors were fed with 50 µg/ml human myelin and changes in the morphology were monitored by light microscopy and by ORO staining to detect intracellular neutral lipids. Although small individual changes in kinetics between individual donors were observed, macrophages acquired a foamy morphology between 24 and 48 h (Fig. 4A and B) and contained a markedly increased number and size of lipid droplets in comparison to control macrophages (i.e. not fed with myelin) as demonstrated by ORO staining (Fig. 4C–F). The typical foamy morphology of macrophages could still be observed 1 week after the initial addition of myelin. Macrophage viability was not affected by myelin ingestion when a dose range of 1–100 µg/ml was used, as demonstrated by trypan blue staining (data not shown).
Foamy macrophages do not mount pro-inflammatory responses to prototypical inflammatory stimuli and produce anti-inflammatory mediators
To assess the effect of myelin ingestion on macrophage function, cytokine levels were determined in supernatants of myelin-laden macrophages before and after LPS stimulation. Since variation in myelin lipid composition between multiple sclerosis and normal brain has been reported (Woelk and Borri, 1973), myelin was isolated from white matter of three control (open symbols) brains and three multiple sclerosis (filled symbols) brains to investigate possible functional differences. Macrophages were incubated with the distinct myelin preparations for 24 h and IL-10 and IL-12p40 levels were determined in the supernatants by ELISA. None of the myelin preparations induced IL-12p40 and only the highest dose of one multiple sclerosis brain-derived myelin was associated with a transient IL-10 induction (data not shown). All myelin preparations inhibited LPS-induced IL-12p40 and IL-10 induction in a dose-dependent fashion (Fig. 5A). No significant differences were observed in cytokine production between foamy macrophages generated using the different myelin preparations. For subsequent experiments 50 µg/ml myelin was used.
Next, the effect of myelin ingestion on LPS-induced mRNA levels of different pro-and anti-inflammatory mediators was determined. Macrophages were incubated with myelin for 24 h and subsequently stimulated with LPS for an additional 2 h, after which RNA was isolated and real-time RT-PCR was performed for IL-12p35, IL-12/23p40, IL-23p19, TNF-α, IL-10, COX-2, PGES and CCL18 (Fig. 5B). LPS-induced IL-12p35, IL-12/23p40 and TNF-α expression by foamy macrophages was dramatically inhibited. LPS-induced IL-23p19 expression was decreased, albeit not significantly (data not shown). IL-10 mRNA was slightly but not significantly induced by LPS in control macrophages as well as foamy macrophages. COX-2 was increased after LPS stimulation in control macrophages but this induction was not significantly inhibited in foamy macrophages. Foamy macrophages showed between 15–50 and 8–12-fold induction of CCL18 and PGES compared to control macrophages. Thus, myelin ingestion resulted in a differential modulation of LPS responses. LPS-induced IL-12p35, IL-12/23p40 and TNF-α mRNA expression was strongly and significantly inhibited, IL-23p19, IL-10 and COX-2 expression remained unaffected and the expression of anti-inflammatory CCL18 and PGES significantly increased.
To determine whether myelin ingestion results in long-term modulation of macrophage function, macrophages were incubated with myelin for the indicated time periods and real-time RT-PCR was performed for IL-12p35, IL-10, PGES and CCL18. IL-10 mRNA was not detectable at any time point (data not shown). After myelin uptake IL-12p35 expression was decreased, albeit not significantly, over time in comparison to control macrophages (Fig. 5C). In contrast to IL-12p35 both PGES and CCL18 were induced by myelin (Fig. 5C). Seven-day-old foamy macrophages expressed 10- and 90-fold more PGES and CCL18 than control macrophages. IL-12p40, IL-10 and CCL18 levels were subsequently determined in supernatants of these foamy macrophages. CCL18 is constitutively produced by macrophages and production by foamy macrophages is increased at day 7 after myelin ingestion (Fig. 5D), paralleling the increased CCL18 mRNA expression by foamy macrophages. IL-12p40 and IL-10 were not detectable (data not shown).
Subsequently we determined whether the aberrant LPS response persisted over time. Seven days after initial myelin ingestion foamy macrophages were stimulated with 1 ng/ml LPS for 24 h and cytokine levels in the supernatant were determined by ELISA. LPS-induced IL-12p40 and IL-10 production by these foamy macrophages was abolished completely (Fig. 5E) whereas CCL18 was significantly increased (Fig. 5E). In addition, responses to other prototypical pro-inflammatory stimuli such as peptidoglycan and zymosan were also completely abolished (data not shown).
The relapsing-remitting nature of multiple sclerosis strongly suggests the presence of potent counter-regulatory mechanisms that keep the disease in check. One such mechanism may be the active control of inflammation in the CNS itself thus preventing infinite expansion of the demyelinating lesion. Inflammation and demyelination are responsible for at least short-term neurological symptoms. Inflammation probably contributes to axonal loss as neurons are more vulnerable to environmental insults when the protective myelin sheaths are destroyed and the axons exposed (Kuhlmann et al., 2002; Grigoriadis et al., 2004). It is therefore imperative that in the developing lesions the production of toxic molecules is halted and that inflammation is limited allowing for tissue repair (Sospedra and Martin, 2005). Myelin-laden foamy macrophages are abundantly present in demyelinating lesions and although it is generally assumed that these cells contribute to inflammation, evidence for this is scarce (van der Laan et al., 1996). This lack of data on foamy macrophage function in multiple sclerosis is in sharp contrast with the increasing attention for foam cells in atherosclerosis (Greaves and Gordon, 2005) reporting potent immune-regulatory functions by lipids and lipid-induced molecules (Harris et al., 2002; Lawrence et al., 2002; Pettus et al., 2002; Joseph et al., 2003, 2004). Lipid-laden cells are anti-inflammatory (Lawrence et al., 2002) and it was shown that low-density lipoprotein (LDL) uptake by macrophages inhibits TNF-induced TNF expression and induces IL-10 (Lo et al., 1999; Varadhachary et al., 2001; Ares et al., 2002). Foamy macrophages in the rim of active demyelinating multiple sclerosis lesions have been shown to contain plasma LDL (Newcombe et al., 1994).
Here, we establish that foamy macrophages in active multiple sclerosis lesions have consistent immunosuppressive function, while displaying a unique surface phenotype dependent on the micro-location. In addition, we demonstrate that ingestion of human myelin alters human macrophage function in vitro by inducing anti-inflammatory molecules and by inhibiting responses to pro-inflammatory stimuli. The results presented here reveal a new regulatory immunosuppressive pathway in multiple sclerosis.
We demonstrate that foamy macrophages in demyelinating lesions in multiple sclerosis brain express various markers that are involved in anti-inflammatory processes, including IL-1ra, IL-10 CCL18, TGF-β and that a subset of the foamy macrophages express markers involved in innate immunity, including mannose receptor and CD163. These molecules are all characteristic for alternatively activated M2 macrophages (Mantovani et al., 2002; Gordon, 2003; Mosser, 2003) and this strongly suggests a local regulatory immunosuppressive role.
Importantly, our data show that foamy macrophages occur in discrete subsets. This may reflect their origin (i.e. microglial-derived versus blood-derived) and the degree of lipid degradation. Most likely the cues received from their microenvironment are critical. These cues include the type of ingested lipids, cytokine environment, presence and identity of neighbouring cells and signals from the extracellular matrix. The unique combination of surface and intracellular molecules of individual macrophages in different areas of the lesion suggests that they are likely to exert diverse functions depending on their location. Foamy MOG macrophages in the lesion rim may be more involved in phagocytosis of myelin whereas foamy macrophages inside the lesion appear to be geared for downregulation of inflammation as suggested by high expression of anti-inflammatory cytokines. Interestingly, our in vitro data show a transient increase in PGES expression and a sustained increase in CCL18 expression. This parallels the in situ analysis showing highest expression of PGES in foamy macrophages in the lesion rim that likely have ingested myelin more recently than foamy CCL18-positive macrophages in the lesion centre. Although LPS-induced IL-23p19 expression was not significantly decreased in foamy macrophages, expression of the other subunit of IL-23, p40, was strongly inhibited. This indicates a reduced capacity of foamy macrophages to produce both IL-12 as IL-23 after LPS stimulation. Importantly, the p40 subunit is critical in the development of EAE, an animal model for multiple sclerosis and forms the basis of the Th1 bias of the CNS (Becher et al., 2003). IL-10 was expressed in situ mostly by lesional foamy macrophages. However, in in vitro LPS-induced IL-10 production is strongly inhibited upon myelin ingestion. This suggests complex regulation of IL-10 expression both in vitro and in vivo warranting more detailed exploration. Regulatory foamy macrophages in perivascular spaces are likely to affect the function of newly infiltrating cells. Current experiments employ genomic as well biochemical approaches to identify such immunomodulating mechanisms.
We hypothesize that the observed functional phenotype of foamy macrophages in multiple sclerosis lesions results from the accumulation of lipids derived from myelin and phagocytosed apoptotic cell membranes, in concert with local micro-environmental cues, such as differences in extracellular matrix content in the perivascular infiltrate versus the lesion in the brain parenchyma. Foamy macrophages demonstrate a phenotype resembling that of anti-inflammatory M2 macrophages, are likely to contribute to resolution of inflammation and may therefore be responsible for inhibiting further lesion development and promoting lesion repair. In addition, they may also function as a first line of defence against infiltrating inflammatory myeloid cells. Future studies are required to elucidate which lipid components are able to regulate macrophage function and which mechanisms are involved. Understanding the mechanisms behind naturally occurring counter-regulatory processes will allow for definition of new cellular targets for therapeutic drug design for the treatment of multiple sclerosis and may well have broader applications for other foam cell-associated diseases including atherosclerosis.
The authors thank Drs Leslie van der Fits, Bert 't Hart and Hans van Noort for helpful discussions, Marri Verhoek, Karin Assink and Jane Voerman for technical assistance, The Netherlands Brain Bank (coordinator Dr R. Ravid) for supplying brain tissue and Tar van Os for photomicrographs. This work was supported by a program grant of the Multiple Sclerosis Research Foundation to the Rotterdam Multiple Sclerosis Centre ErasMS and a grant of the Dutch Brain Society (to L.A.B., 12F04.24)
Author notes
1Departments of Immunology and 2Neurology, part of the multiple sclerosis Centre ErasMS, 3Department of Pediatrics, Erasmus Medical Center, Rotterdam, 4Department of Medical Biochemistry, Academic Medical Center Amsterdam, 5Biomedical Primate Research Center, part of the multiple sclerosis Centre ErasMS, Rijswijk, The Netherlands


text: Always great food at Mr. Taco. This is our go to place for Mexican Food. Always authentic and always delicious. They have a huge menu to choose from and there is something for everyone. Their Burritos are full of meat instead of the beans you get at many mexican restaurants.


text:
dinky 24 in glovetanned leather
The new Dinky puts a modern spin on an iconic 1973 Coach design. With a nostalgic look toward the past, this re-edition comes with a leather-and-chain strap and an attached French purse inside, an archival element first introduced by Bonnie Cashin.View Details
- Glovetanned leather
- Interior French purse pocket
- Turnlock closure, leather lining
- Outside slip pocket
- Removable strap with 22" drop for shoulder or crossbody wear
- 9 1/2" (L) x 7" (H) x 3 1/4" (W)
- Coach 1941 collection
- Reviews
[{"linkedProduct":[],"category":{"primaryCategory":""},"attributes":{"isOnlineExclusive":"","skuComplete":"55148 BPBLK"},"productInfo":{"description":"The new Dinky puts a modern spin on an iconic 1973 Coach design. With a nostalgic look toward the past, this re-edition comes with a leather-and-chain strap and an attached French purse inside, an archival element first introduced by Bonnie Cashin.","manufacturer":"coach","productID":"55148 BPBLK","styleNo":"55148","productName":"DINKY 24 IN GLOVETANNED LEATHER","productThumbnail":"http://img1.cohimg.net/is/image/Coach/55148_bpblk_a0?fmt=jpeg&wid=1034&qlt=75,1&op_sharpen=0&resMode=bicub&op_usm=5,0.2,0,0&iccEmbed=0","productImage":"http://img1.cohimg.net/is/image/Coach/55148_bpblk_a0?fmt=jpeg&wid=1034&qlt=75,1&op_sharpen=0&resMode=bicub&op_usm=5,0.2,0,0&iccEmbed=0","productURL":"http://www.coach.com/coach-dinky-crossbody-24-in-glovetanned-leather/55148.html?dwvar_color=BPBLK","size":"","color":"BPBLK"}}]
DINKY 24 IN GLOVETANNED LEATHER is rated out of 5 by 3.
Rated 5 out of 5 by B65farm from Beautiful classic bag I have purchased this bag after using my tea rose Dinky, which I love also. This bag has just a little more room, so I don't have to work so hard to get everything in the bag. Love the feel of the leather, the classic look and the kiss lock inside pocket are fabulous! I have my small wallet, phone, keys, and compact and lipstick and enough to put something else in if I needed to. I like the strap with the leather and chain, nice look and with the leather it doesn't rattle all the time. Used it 4 times now, shopping at the Farmer's Market and for a night out, worked great, and unlike my other small bags I used it the next day too. Nice classic bag I can use for a long time, love it!
Date published: 2016-09-28
Rated 4 out of 5 by Lamama from Classic bag with beautiful leather I bought this in Bordeaux and I love it. The size and shape are simple and classic. It is big enough for all my necessities , yet not so big as to look clunky or bulky. The strap is very pretty, but not comfortable if there is much weight in the bag. I am looking to purchase a leather strap for it for days when I carry my purse for more than an hour. My usual days involve carrying the purse to and from the car, work, store, etc and the chain is not a problem for short times. The strap can also be doubled and carried on the arm which definitely is better.
Date published: 2016-09-11
Rated 1 out of 5 by PrettyReese from Absolutely painful bag! The leather is great Coach quality but the chain that you carry with weather it's over the shoulder or cross body is just painful - literally!! It digs into your skin & i even purchased the matching plain gun metal chains to see if it would be better - NOPE / just as bad. I feel horrible as i bought this pocket book specifically to go on vacation to Hawaii & ive carried thru air port in absolute PAIN. So disappointed- i am a HUGE Coach customer & never had this issue before. Waste of $$$. Would luv to talk to a representative about this issue which is supposed to reflect quality
Date published: 2016-06-08


text:
Pasta Sfoglia: From Our Table To Yours, More Than 100 Fresh, Seasonal Pasta Dishes by Ron and Colleen Suhanosky, includes recipes like Fresh Egg Pasta; Triangoloni, ricotta, amaretti, radicchio, balsamic; and Bucatini all'amatriciana.
by Ron and Colleen Suhanosky
Tables at Sfoglia in Manhattan and Nantucket are much sought-after by the fans of the restaurant's authentic and delicious cuisine. Now, you won't have to wait long for a table at Sfoglia. With Pasta Sfoglia: From Our Table To Yours, More Than 100 Fresh, Seasonal Pasta Dishes, home cooks can prepare master recipes right in their own kitchens. Here, for the first time, chef-owners Ron and Colleen share recipes from their kitchen, enabling home cooks to make sophisticated pasta dishes with efficiency and ease.
Beautifully illustrated in full-color, Pasta Sfoglia lets home cooks:
Anyone who loves pasta and cuisine grounded in traditions and uncompromised flavor, Pasta Sfoglia is the perfect collection to inspire home cooks to bring their own traditions to the table.
Ron Suhanosky and Colleen Marnell-Suhanosky are graduates of the Culinary Institute of America at Hyde Park. Ron has held several positions in New York City restaurants including the River Cafe and the Park Avenue Cafe, and Colleen cooked at Biba in Boston before they traveled together to Italy and cooked at various restaurants including II Cibreo in Florence and La Crota in Alba. When they returned, Ron worked at Boston's Alloro and Galleria Italiana and at II Buco in New York, and Colleen honed her pastry making skills at La Bettola in Boston and under Claudia Fleming at Gramercy Tavern in New York. They opened their first Sfoglia restaurant in 1999 and Tutto Sfoglia in 2007 on Nantucket Island, and opened another Sfoglia restaurant in Manhattan in 2006. They live in New York City with their three children and spend the summertime and holidays on Nantucket.
Buy Pasta Sfoglia
This page created November 2009
The FoodWine
Main Page
Kate's Global Kitchen
Kate's Books
Cookbook Profiles
Global Destinations
Holiday & Party Recipes
I Love Desserts
On Wine
Caffeine and You
Cooking with Kids
New Green Basics
Conversions, Charts
& Substitutions
About FoodWine
Contact Info
Privacy Statement
Anatolia: Turkish Recipes
Bar Tartine
The Beer Bible
Beetlebung Farm Cookbook
Bird in Hand (Chicken)
Bitter: Flavor
Bob's Joke Burgers
Cooking Light
Darjeeling Tea
Dinner at Home
Everyday Baker
Fast Food (Andrew Weil)
Flavor Flours
Food 52 Genius
The Food Lab
Garden Recipes
Grandmas' Recipes
Hartwood: Yucatán
Humane Butchering
Heritage Southern Recipes
Jemima Code African Recipes
Kitchn Cookbook
Liquid Intelligence
Near & Far World Recipes
NOPI Restaurant Cookbook
Oxford Companion to Wine
Phoenix Claws: Chinese
Picnic: Recipes
Soda Politics
Southern Recipes
The Third Plate
V Is for Vegetables
Vegetarian India
What Katie Ate
The Whole 30
Whole Food Kitchen
Yucatán Recipes
Zahav Israeli Cooking
Copyright © 1994-2016,
Forkmedia LLC


text:
Tuna Tartar With Creme Fraiche And Beluga Caviar
|Yellowfin tuna
|12 Ounce, diced 1/2 inch (Fresh)
|Soy sauce
|1 Tablespoon
|Wasabi powder
|1⁄2 Teaspoon, mixed with 2 tablespoons water
|2 Tablespoon
|Chopped cilantro
|1 Teaspoon
|Snipped chives
|1 Teaspoon
|Quail eggs
|4 (Available In Specialty Food Shops)
|Creme fraiche/Sour cream
|1 Cup (16 tbs)
|Beluga caviar
|2 Ounce
|Chervil sprig
|1 Cup (16 tbs)
|Sun dried tomato oil
|1⁄2 Cup (8 tbs)
|To Taste
|To Taste
1)Take a bowl, combine together tuna, wasabi and water, cilantro, chives, salt, pepper and soy sauce.
2)Place non-stick pan on heat, crack open quail eggs into the pan and cook them sunny side up for 3 minutes.
3)Take a serving plate, keep a ring mold of 3 ½ inch at the center of plate. Fill the mold with tuna mixture to the brim. Gently top with creme fraiche or sour cream. Remove ring.
4)Garnish with quail eggs, caviar and chervill sprigs.
5)Decorate serving plate with chervill sprigs and tomato oil.
6)Serve warm.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1479 Calories from Fat 529
% Daily Value*
Total Fat 59 g90.9%
Saturated Fat 4.2 g20.8%
Trans Fat 0 g
Cholesterol 833.3 mg277.8%
Sodium 4846.4 mg201.9%
Total Carbohydrates 100 g33.4%
Dietary Fiber 19 g75.8%
Sugars 45.7 g
Protein 151 g302.5%
Vitamin A 87.4% Vitamin C 113.7%
Calcium 83.2% Iron 180.3%
*Based on a 2000 Calorie diet


text:
The needs of the fishing sector range from day-to-day operational support to the navigation and positioning of fishing vessels. Strict international rules governing intrusion into national waters demand that vessels are monitored to check they work only in designated areas.
Some examples of practical uses of GALILEO:
Navigation and monitoring of fishing vessels
The long journeys and the global nature of fishing activities mean that satellites provide the only viable and reliable method of navigation. Modern fishing vessels travel the globe pursuing commercial returns, at the same time sending regular position reports (position, speed and heading) to their shore-based control centres, and occasionally catch information and a breakdown of fishing effort. National and international laws mean that non-compliance can prove very expensive in terms of fines and withdrawal of fishing rights.
Monitoring fishing applications
Fishermen need accurate position information to locate their assets. Traditional methods often rely on local knowledge and historical patterns of net laying. Transmissions back to the mothership from free-floating and static devices will improve fishing capabilities.
Uninterrupted views of the sky make the high seas an ideal environment for drawing on satellite technology.
GALILEO Application Sheet: Agriculture & Fisheries (133 Kb)
|dernière mise à jour : 10-02-2009


text:
"in light of the constant rape, murder, racism, homophobia and misogyny that goes on seemingly every day i feel the need to make clear who i personally make music for, and who i dont."
"I'm team SWISH"/i>."
For embracing angst in solitude.
Your new summer song.
First 8 Mistakes is out tomorrow on W'vves' Ghost Ramp label.
Available now via Ghost Ramp.
Featuring Vampire Weekend's Rostam Batmanglij.
"It is the soundtrack to nihilist future acid punk versions of these worlds."
Wavves pre-season comin' on.


text:
Mon, 04 Apr 2011
92 comments
One of Canada's finest steps up.
Fri, 29 Oct 2010
20 comments
O Canada. RA talks Toronto with New Kanada's guiding light.
15 comments
2 comments
10 comments
9 comments
11 comments
4 comments
Thu, 24 Mar 2016
1 comment
The New Kanada boss and Graze member puts together tunes from DJ Richard, Call Super and Jared Wilson, with a full-length visual accompaniment.
Wed, 10 Feb 2016
Post a comment
The black-and-white clip accompanies "Sunless See," a charging cut from the New Kanada founder's new EP.
Mon, 30 Dec 2013
DJ Broadcast talks to artists who produce together despite living oceans apart, including Graze, Donor/Truss and Snuff Crew.
Tue, 3 Dec 2013
9 comments
selftitledmag is streaming Edges, the duo's first collaborative LP.
Thu, 12 Sep 2013
Number 7 in the Ilian Tape podcast series comes from New Kanada head Mr. Adam Marshall from Toronto. Comes with a little interview. Enjoy!
Thu, 29 Nov 2012
The Canadian DJ puts together a mix of "tracks that have no kick, no percussion and minimal structure" for Modyfier Process. Artists include Demdike Stare, Surgeon, DJ Sprinkles, Bee Mask, Oneohtrixpointnever, Sandwell District and The Caretaker.
Mon, 5 Dec 2011
The New Kanada sub-label will kicks things off with a release from Marshall himself, backed by a remix from fellow Canadian producer Kevin McPhee.
Tue, 25 Oct 2011
3 comments
The Canadian ex-pat gets tough with techno and house (and just a little bit funky) on his fall promo mix.
Thu, 30 Dec 2010
Thu, 29 Apr 2010
13 comments
New Kanada boss Adam Marshall cooks up an hour of bittersweet dancefloor treats for Roof.fm.
Wed, 10 Sep 2008
New Kanada boss Adam Marshall provides LWE with an hour-long mix which seamlessly spans deep-house and techno with personalized edits.
Wed, 14 Oct 2015
The annual Open Studios Halloween bash also features Noah Pred and James Flavour.
Tue, 6 Oct 2015
The Berlin label will host a night at the Toronto nightspot next week.
Mon, 27 Jul 2015
Noah Pred and Timo Maas will also play the Winnipeg festival next month.
Wed, 8 Apr 2015
2 comments
Adam Marshall and Christian Anderson will perform live in Toronto later this month.
Fri, 12 Sep 2014
The duo's second album will hit the shelves via New Kanada in November.
Mon, 16 Jun 2014
7 comments
The Vancouver festival has announced the first wave of names for its 2014 instalment in September.
Sat, 1 Mar 2014
Art Department, Oskar Offermann have offered up tracks for the Toronto label's latest collection.
Tue, 11 Feb 2014
The new compilation features beatless cuts from Ricardo Tobar, The Mole and plenty of others.


text:
Irish Soda Bread
|Bread flour
|2 Cup (32 tbs), sifted
|Baking powder
|2 Teaspoon
|Baking soda
|1 Teaspoon
|1⁄2 Teaspoon
|1 Tablespoon
|Sour milk
|2⁄3 Cup (10.67 tbs)
Sift dry ingredients into bowl.
Cut in shortening and add enough sour milk to make dough easy to handle.
Turn onto floured board and form into round loaf.
Bake in 350F oven 1 hour.
(Can be tested as a cake with knitting needle.) Served fresh with butter and blackberry jam for preference
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1055 Calories from Fat 229
% Daily Value*
Total Fat 26 g40%
Saturated Fat 9.2 g46%
Trans Fat 2 g
Cholesterol 0 mg
Sodium 3290.9 mg137.1%
Total Carbohydrates 166 g55.2%
Dietary Fiber 4.8 g19.3%
Sugars 20.3 g
Protein 37 g73.9%
Vitamin A 0.1% Vitamin C 1.6%
Calcium 123.1% Iron 16.4%
*Based on a 2000 Calorie diet


text:
Fisher Says 'Super-Easy' Fed Can't Alone Boost ManufacturingSteve Matthews and Jeff Kearns
Federal Reserve Bank of Dallas President Richard Fisher, one of the most vocal critics of bond purchases by the central bank, said record Fed stimulus can't revive U.S. manufacturers from a two-year slump caused by ambiguity in regulation and fiscal policy.
"They have been given abundant, super-cheap monetary fuel needed to stoke up their production engines and expand their businesses," Fisher, who doesn't vote on monetary policy this year, said today in a speech in Orlando, Florida. "What is holding us back" is "fiscal and regulatory policy of the gang that can't shoot straight in Washington."
Minutes of the Federal Open Market Committee's July 30-31 meeting released yesterday show Fed officials are comfortable with Chairman Ben S. Bernanke's plan to start reducing bond buying later this year if the economy improves. Treasury yields reached two-year highs today as reports showed a strengthening job market and a gain in economic indicators, suggesting the expansion may be strong enough for the Fed to reduce stimulus.
"I would have liked to start cutting back earlier," Fisher said to reporters after his speech. "The economy is strong enough" for slowing purchases.
The U.S. is "moving in the right direction" with the performance of the job market, a trend that "has to be evaluated against the costs of continuing" bond purchases, he said.
'Very Balanced'
The Dallas Fed leader said he regarded the minutes from the FOMC's meeting last month as "very balanced -- to me, they were neither hawkish nor dovish," and "represented the conversation perfectly well."
U.S. stocks rose with the Standard & Poor's 500 Index gaining 0.9 percent to 1,658.12 at 3:36 p.m. in New York. The yield on the 10-year Treasury note was little changed at 2.89 percent.
Fisher said in his speech that "there are many risks in the policy that the Fed has been pursuing," without elaborating. In an interview with Bloomberg Television, he reiterated his view that the central bank should taper the $85 billion in monthly bond purchases at its Sept. 17-18 meeting, "provided that economic reports don't disappoint."
During a tapering, policy makers must be "careful not to be disruptive" to financial markets, he said in the interview with Megan Hughes.
The FOMC should first scale back purchases of mortgage-backed securities because the market for such debt is smaller than the one for Treasuries, Fisher said. The central bank each month is buying $45 billion of Treasuries and $40 billion in mortgage bonds.
'Tough Business'
"That's a tough business for us to be in because it's a very thin market," Fisher said of the market for mortgage-backed securities. "We're basically up to the point where we're going to be buying 100 percent of the issuance at some point and nobody wants to be on the buy side to that extent, at least I don't want to be."
The FOMC will probably vote next month to scale back the unprecedented stimulus program, according to 65 percent of economists surveyed by Bloomberg Aug. 9-13. The first step may be to reduce monthly purchases by $10 billion, according to the median estimate in the survey of 48 economists. They said buying will probably end by mid-2014.
Fisher declined to say who he believes should become the next Fed chairman when Bernanke's term expires in January, adding that he would like Bernanke to stay on for a third term.
Bernanke's "legacy will be someone who brought about a totally innovative way to conduct central banking," said Fisher. "I love the guy. He's led us very effectively."
Fisher spoke today primarily about U.S. manufacturing.
'Great Gift'
"Every manufacturer of goods in America has been given a great gift by your central bank -- the lowest cost of money in 237 years, an extension of the roaring bond market rally that has now run 32 years and a broad stock market rally that began in March of 2009," Fisher said to a conference hosted by Wal-Mart Stores Inc. and the National Retail Federation.
Fisher, 64, a former money manager and deputy U.S. trade representative, has been president of the Dallas Fed since 2005. In 2011, he dissented twice against efforts to push down long-term borrowing costs and keep the benchmark interest rate near zero for a prolonged period. He voted in favor of tighter policy five times in 2008. His district includes Texas, northern Louisiana and southern New Mexico.


text:
2016 - 2017 Concerts
Concert at the Buell with The Annie Moses Band
October 15 at 7:00 PM possibly at The Buell Theater This is a full evening of entertainment with The annie Moses Band, All choirs and the Chamber Orchestra
Knight of Jazz- November 17th 7:00pm Featuring Jazz Band 1, Age of Guinevere and Excalibur
December 14th and 15th at 7:00 PM in the Fairview Auditorium Choirs Performing: Dec 14th - Voices of the Knight men/women, Chivalry, Kingsmen, Troubadours, Age of Guinevere, and Excalibur Dec 15th - Enchantment, Madrigals, Festival, Age of Guinevere, and Excalibur
March 16, 7:00pm at Ascent Church. This concert will feature many Fairview choirs, Enchantment, Festival, Madrigals, and our Classic Knights Chamber Orchestra, and Symphonic Band. This is one performance not to miss! ---
TROUBADOURS AND VOICES EVENT Dessert Theater
March 14th 7:00pm Treat your loved ones to an evening of enjoyable musical performances and delectable dessert selections! On Tuesday, March 14th, a variety of auditioned musical acts will be performed by freshman and sophomore students from the Fairview Choir Department. This event will take place in the transformed cafeteria turned "Cabaret". Seating is limited, but desserts are plentiful! Tickets ($7.00 general seating) will be available on line or at the door on the evening of the 15th. ---
May 10th and 11th at 7:00 PM in the Fairview Auditorium Tuesday, May 10th - see: Troubadours, Kingsmen, Voices of the Knight, men and women, Festival, Chivalry, Mass Choir Wednesday, May 11th - see: Festival, Enchantment, Madrigals, Age of Guinevere, Excalibur, Mass Choir


text:
$419.00Go to HomeDepot.co...
Basic wire welding for projects and repairs around the shop farm or home that where the Weld-Pak 125 HD comes in handy. Plug in the Weld-Pak 125 HD anywhere common 120-Volt input power is available....More
Unknown Tax
Shipping N/A
|New Item
Find, Compare, Read Reviews & Buy the Lincoln Electric Welding Tools Weld Pak 125 HD Wire-Feed Welder K2513-1 Online @ Yahoo Shopping Want to see your products in Yahoo Shopping? Advertise with us. Sitemap All Brands
Terms | Privacy | About Our Ads | Help


text:
Electrical Engineer who can use MATLAB
This project received 28 bids from talented freelancers with an average bid price of $457 USD.Get free quotes for a project like this
Project Budget$250 - $750 USD
Total Bids28
Project Description
I am looking for Thesis writer who can work on Electrical Engineering project . Detail will be provided after awarding project.
Happy Bidding.
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text: If you are looking to outfit your control panel with timers that have an attractive LED display, consider the new PTC-20 series that deliver functionality at competitive prices. Designed for you to best fit the correct timer to your application, the PTC-20 series is divided into three separate models. The PTC-21 base unit offers five field-selectable operating modes and time ranges as well as a host of other convenient features. The high performance PTC-23 model offers advanced functions such as dual setpoints and 1 ms resolution. The PTC-22 repeat cycle model provides a repeat cycle (batch stop, batch continue) and interval modes specifically tailored for cyclical operations.With ultimate simplicity in mind, the PTC-20 series utilizes an intuitive button-per-digit method for setpoint input and easy to follow scroll-thru menus for programming. The dual line display optimizes the interface by indicating both the present time value and the setpoint, while up to 8 annunciator lights provide status. Multi-level security enables shop floor access to be custom tailored to your needs.Intended for tough industrial conditions, the PTC-20 Series offer a NEMA-4/IP65 rated front panel and a high degree of noise immunity. Choose from models with a 5 amp relay, which can directly drive a load, or solid state outputs for high speed applications.


text:
HOA Board MembersAlex Hill, Don Czelusniak, Gloria Green, Bob Oroszi, Susan Hull, Matt Cronin, George Mercado, and Phyllis Thompson.
Details coming soon!
Blanco Woods HOA is a Mandatory AssociationWith the filing of a court-certified document on November 17, 2010, all five units in Blanco Woods are now subject to an amended covenant that requires all homeowners to pay mandatory dues assessments ANNUALLY beginning January 1, 2011. Even with the pool and tennis courts, our HOA fee remains one of the lowest in the area! Your neighboring subdivision is $350.00 annually - with no amenities but a closing gate.
Your HOA Board is working very hard for you and will continue to keep the neighborhood looking great - even as it now ages up to 30 years! Things do grow old and obsolete and break down, so our first goal is to keep up the maintenance in the neighborhood to keep it at the high standard you saw when you bought into Blanco Woods. We are here, working responsibly for you.
Blanco Woods
Board of Directors
and Committee Members
HOA BOARD MEETINGS: Your Board is working hard for you!Please try to come to one or more of our meetings. Members are welcome to sit in on a Board Meeting at any time. If you wish to speak at one, you must make prior arrangements with the President.
All meetings are to be held at 7:00 p.m. (promptly) at the First Presbyterian Church on the corner of Blanco Road and Blanco Woods St. Please be present prior to 7:00 p.m.
Your HOA Board and Committee Members try hard to keep your home values up by enforcing the by-laws and covenants of the HOA. They are on this web site if you would like to read them.


text:
Ganesh Mens Hoodie
also known as Ganapati and Vinayaka, is one of the best-known and most worshipped deities in the Hindu pantheon. His image is found throughout India, Sri Lanka and Nepal. Hindu sects worship him regardless of affiliations
We print all Hoodies using the latest DTG print technology and highest quality inks to ensure a superior print quality and a lasting finish. The double fabric hood with self-coloured drawcord and a front kangaroo pouch pocket makes this Hoodie just perfect.
Shipping is £3.99 globally on orders less than £30. Shipping is FREE for all orders over £30. Orders are delivered within 5-7 business days. If you have a query about delivery for a product which you have already ordered, please contact us.
If you don't absolutely love it, we'll take it back!
If you're not happy with your order, please contact us as soon as possible. In all cases we'll ask you to provide photographs of the item, including a close up of any tags/labels. To help us respond to you quickly, please include the order number in your message to us.
We have a money-back satisfaction guarantee, so whatever the problem, we're happy to work with you to fix it.
- Tags: amarakosha, amarnath-temple, annamalaiyar-temple, arthur-anthony-macdonell, ashtavinayaka, atharvaveda, bala-ganapati, ballaleshwar-pali, basholi, bengal, bhadra-month, bhagavad-gita, bhairava, bharata-natyam, bhimashankar-temple, brahmin, brihadeeswarar-temple, b-haspati, ganesha, literature, other, pterocarpus-santalinus, radha, ramanathaswamy-temple, ranjangaon-ganpati, rockfort, ucchi-pillayar-temple, vadodara


text:
The Best Light & Lacy Knit Scarf Patterns: 7 Free Scarf Patterns for You
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
Latest Comments
"Can the legs be made with the same yarn as the rest of the sweater? I think Bernat Berella 4 was discontinued."
"What I cute idea! I have skeins of this fluffy yarn left over and it seems to have gone "out of vogue." This is a clever way to use it up, and I bet I know some little girls who would love these for the bedrooms!"
"I very seldom read an entire knitting pattern before I start because it just makes more sense as I knit along. However, I would recommend giving this one a quick read through. The earflap attachment can be a bit tricky. Just read carefully!!"
"What a clever pattern for those tiny leftovers of superbulky yarn! I can't wait to get these on my needles and clean that basket of scraps out of my closet!"
Crazy Zig Zag Scarf
We are adding the pattern to your Knitting Patterns.
This pattern has been saved to My Knitting Patterns.
Click here to view your Knitting Patterns.
With some straight knitting needles, some worsted weight yarn these scarf knitting instructions, you can create your own accessory with an intriguing visual design. The Crazy Zig Zag Scarf isn't hard to knit either; with just simple knit and purl stitches and subtle decreases, you can finish your own scarf in just a weekend.
Knitting Needle Size: 9 or 5.5 mm
Yarn Weight: (4) Medium Weight/Worsted Weight and Aran (16-20 stitches to 4 inches)
Tags / Related Topics
Your Recently Viewed Projects
Images from other crafters
Love these projects? Get MORE delivered to your Inbox – FREE Click Here!
jerzeygirl709 5396 990
Oct 05, 2012
I tried knitting this pattern and it is not coming out like the picture. In the abbreviations it shows the following stitches Knit, Purl, K2tog, and yo, however the pattern does not contain K2tog or yo stitiches. Help!
Feb 15, 2013
I did not see any K2tog in this zig zag pattern
Ealizabethane 1862 886
Jul 25, 2013
The only place that mentions K2tog and yo is on the abbreviations-these stitches are not actually in the pattern-that is just a note on a few knitting abbreviations, it does not necessarily apply to the pattern. I've done this pattern if you follow it, it does turn out the same as the picture. hopw this helps.
bberk 5020703
Mar 08, 2012
I'm logged in, but the pattern still does not download. Any suggestions.
Mar 09, 2012
@bberk 5020703, I'm sorry, we are able to access the pattern just fine on our end. It should automatically open in a new window when you click where it says, "Click here for knitting pattern." If this is not the case, you may be working from an outdated browser. Please try downloading the most current version of Internet Explorer, Firefox, Google Chrome, or Safari to see if that helps. Thank you! --Editors of AllFreeKnitting
Feb 15, 2013
It downloaded for me. Adobe. I downloaded it with the picture not just Text.
Report Inappropriate Comment
Are you sure you would like to report this comment? It will be flagged for our moderators to take action.
Thank you for taking the time to improve the content on our site.
Something worth saving?
- SAVE all your favorite patterns
- ADD personal notes
- QUICKLY reference your patterns
Free eBooks
- 15 Free Cute Knitting Patterns for Every Season
- 24 Quick and Easy Knitting Patterns
- 9 Free Knitting Patterns Perfect for Spring
- A Knitters Gift Guide: 8 Homemade Gift Ideas
- A Yarn Hoarders Guide to Organization: Knitting Storage Solutions, Simple Knitting Patterns and More
- Easy Lace Knitting Patterns
- How to Knit for Beginners: 9 Free Tutorials
- The Best Light & Lacy Knit Scarf Patterns: 7 Free Scarf Patterns for You


text:
Nene King
By (author) Peter FitzSimons
Format: Paperback
Checking availability...
Nene King by Peter FitzSimons
Book DescriptionLoud, lusty and controversial - Nene King was the queen of the Australian magazine world. She was the women's magazine editor with the golden touch, for whom no cheque was too large to write, no paparazzi shot too intrusive, no story too outrageous - so long as she was able to serve up must-have magazines for her readers. Nene took Woman's Day to the position of Australia's number-one weekly magazine and became one of Australia's most powerful women: feared by the stars, courted by politicians, a confidante of Kerry Packer, and Queen Bee of the celebritocracy. In this bestselling book, Australia's most popular biographer, Peter FitzSimons, not only reveals the stories behind the stories, but also documents the extraordinary contours of Nene's own life. Her journalistic career took her all the way from interviewing a young housewife by the name of Hazel Hawke - who told her that she thought herself of 'no news value' - to paying the same Hazel a king's ransom years later for the exclusive rights to her side of the story of her break-up with Bob. Along the way she interviewed Mae West, met Diana, Princess of Wales, and introduced Athena Starwoman and feng shui to women around the country. Propping her up and keeping her going for 22 years was the great love of her life, Patrick Bowring. But on 24 May 1996, Nene's life changed forever ...
Buy Nene King book by Peter FitzSimons from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780732275679
(206mm x 151mm x 39mm)
Pages: 496
Imprint: HarperCollins Publishers (Australia) Pty Ltd
Publisher: HarperCollins Publishers (Australia) Pty Ltd
Publish Date: 21-Apr-2004
Country of Publication: Australia
Other Editions...
Books By Author Peter FitzSimons
View all books by Peter FitzSimons
» Have you read this book? We'd like to know what you think about it - write a review about Nene King book by Peter FitzSimons and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Facebook Page | Twitter | Google+ | Bulletin e-Newsletter | Blog | RSS
Become a Member | Book Lists | Recently Released | Coming Soon | Fast Delivery Books
Bestselling Books: Our Current Bestsellers | Australia's Hottest 1000 Books | Bestselling Fiction | Bestselling Crime Mysteries and Thrillers | Bestselling Non Fiction Books | Bestselling Sport Books | Bestselling Gardening and Handicrafts Books | Bestselling Biographies | Bestselling Food and Drink | Bestselling History | Bestselling Travel Books | Bestselling School Textbooks & Study Guides | Bestselling Children's General Non-Fiction | Bestselling Young Adult Fiction | Bestselling Children's Fiction | Bestselling Picture Books | Top 100 US Bestsellers
For: Schools | Organisations | Libraries | Publishers | Authors | Book Clubs | Bloggers | Affiliates
About Us | Contact Us | Help Desk | Security | Privacy | Terms of Use | Copyright
Phone: 1300 36 33 32 (9am-5pm Mon-Fri AEST) - International: +61 2 9960 7998 - Online Form
Address: Boomerang Books, 878 Military Road, Mosman Junction, NSW, 2088
© 2003-2017. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687
For every $20 you spend on books, you will receive $1 in Boomerang Bucks loyalty dollars. You can use your Boomerang Bucks as a credit towards a future purchase from Boomerang Books. Note that you must be a Member (free to sign up) and that conditions do apply.


text:
Dog training9815665
or Capoeira. michael kors handbags outlet seek out a coach, but when taken as a whole the argument is coach outlet Sign as Kobe's image in NBA, Kobe Bryant shoes has exceed coach outlet because your Steven Tylers daughter. you rock!! keep up the http://www.cheapnfljerseysfan.com/ abusing some stiff. If you are lucky enough, old school hoop http://www.mkhandbagsoutlets.us.com/ great sign of things to come. By adding Harden, Adidas can http://www.thenfljerseychinacheap.com/ over $129 million sitting on the balance sheet and a http://www.mkhandbagsoutlets.us.com/ He attended high school in Wilmington, North Carolina, and http://www.thecoachbagsoutlet.us.com/ television viewers. Lin helped the company achieve higher teammates for such a breach of trust in the age before


text:
|Property type
|Minimum Stay
|2 - 3 nights
The skiing is amazing and you will love coming "home" to this warm, cozy chalet. Reserve from two to five nights at this special rate plus cleaning and taxes.
Indulge yourself in this inviting vacation home in the heart of some of the best recreation the northwest has to offer. Fully furnished and custom decorated, Mountain Mist Chalet is ready to welcome your family and friends for an unforgettable experience. Spend the day hiking nearby trails, sightseeing at Mt Rainier National Park or in winer skiing at the expanded White Pass Ski area then come home and relax in the hot tub or in front of the gas fireplace while watching a movie on the large flat screen TV.
The kitchen is well equipped with everything you'll need to prepare anything from a snack to a full course meal. Three bedrooms, each with a queen bed, give up to six guests a restful and peaceful night's sleep. Two of bedrooms are located upstairs and the other downstairs. One of the upstairs bedrooms has a TV and an Atari video game. A bathroom is located on each floor.
An outdoor eating area, charcoal grill, and hot tub await you after a day of activity. A fire pit is located on the property and firewood is provided. S'mores anyone?
The Cowlitz River is just a short walk from the chalet offering a great place to see eagles and elk, to cool off in the water, or for a leisurely walk.
Keywords: Cabin, Chalet, Vacation Home
The house really becomes a home as soon as you walk in. Everything is clean, the furniture, the air, the kitchen. Beds are comfortable, plenty of lights. Clearly thought has gone into the furnishings and decorations, cozy but not cloying. Easy walks to nearby creek and bit further to the river. Good amount of privacy without being isolated.
Communication with Jan was easy and immediate.
Would stay there again in a heartbeat.
Had a comfortable relaxing time - enjoyed celebrating Christmas, lounging over too much coffee and caramel corn, completing a torturous 1,000 piece puzzle, and watching snow fall outside. A bald eagle kept an eye on us during our riverside walk, and we found some great sledding for the little boys at White Pass. Overall a terrific stay. Thank you!
What an awesome home. Maybe too nice, since we were there with 6 children, our goal was to leave early each morning to go to Rainier and St Helens, but with the spacious main room, hot tub, great trail to the river and all new bathrooms/showers, we had a tough time getting everyone to leave the house to go hiking! If and when we return, I'm looking NO further than this location. Make sure to check out the trail to the river. It's right across the road and only .25 mile walk to a beautiful river and view!
Honestly, if this was MY HOUSE, I would not change a thing!
Thanks Again for letting us stay.
Mark C
South Park Pa
My husband and I wanted to get away from our busy lives and have a relaxing weekend to celebrate 22 years of marriage. We certainly found that at the Mountain Mist Chalet. It felt so inviting the minute we walked in the door. Everything was immaculate even down to the drawers, cupboards, refrigerator and stove. The trail to the river was easy and the river fun to explore. I didn't even mind cooking because the kitchen was well stocked and open to the living area. We have done a lot of vacation rentals through VRBO and this is one of the best. Keep up the good work!
My husband, 11 month old son, and I stayed at this property over the July 4th holiday weekend. We were looking for a quieter way to spend the 4th than our home which is right in the middle of the Seattle fireworks party zone. We got exactly what we were looking for.
We enjoyed the peaceful surrounding neighborhood of the house and the nearby river. We also really loved having the outdoor hot tub available on the property. We found the living room and kitchen to be stocked with everything (and more) that we needed to entertain ourselves and our son and to prepare meals for the whole family. Plus we really appreciated how close we were to stores in Packwood as well as hiking trails in Mt Rainier park.
The house is very clean and comfortable and very professionally managed. All in all, we were especially impressed with the house and its amenities. We would definitely stay there again and recommend it to our family and friends.
My family of four stayed in the Mountain Mist Chalet and really enjoyed it. It is very clean. The beds have nice linens and were comfy. My kids loved the Atari game along with lots of board games and books. The kitchen was well stocked. The home has an open layout, which was great for our family. The hot tub was nice and we enjoyed walking to the river. It is very quick to get into Packwood and Mt. Rainier from the chalet. If you are looking for a home to rent in this area, I recommend this one!
Mountain Mist Chalet is located about 20 minutes from White Pass Ski Area and 10 minutes from the entrance to Mt. Rainier National Park. To the south is the Gifford Pinchot National Forest offering hundreds of hiking trails, wilderness areas and wildlife. Take a day trip to Mt St Helens and visit the National Volcanic Monument.
|Rate Period
|Weekend Night
Memorial Day
May 26 2017 - May 28 2017
3 night minimum stay
|Notes: Rates are based on 4 guests; add $15 per night, per additional guest
Independance Day
Jul 1 2017 - Jul 4 2017
3 night minimum stay
|Notes: Rates are based on 4 guests; add $15 per night, per additional guest
My Standard Rate
2 night minimum stay
|Notes: Rates are based on 4 guests; add $15 per night, per additional guest
|Refundable damage deposit
|Cleaning fee
|$70 + Tax
|Pet Fee
|$20 + Tax
|Tax Rate
Pet fee - $20 for three nights or less, additional fees may apply if stay is longer.
Contact owner for off season and last minute specials.
VISA, MasterCard, Discover


text:
|Natsuyuki Rendezvous
jp. Yuuichi NAKAMURA
|Natsuyuki Rendezvous
I know he's supposed to be "the good guy", but man, he's kind of an asshole. First of all, just because you confess to a girl doesn't make her obliged to date you. And ffs her husband died! Even if she likes you back or has confused feelings about you, of course she's going to need some time to think things through. What do you expect?
Older brother of Oreki?


text:
Pocket Wizard Plus II Transceiver
7 Days
Retail: $120.00$18.00
Damage Waiver:
No Damage Waiver
You are liable for any damage or loss to the rental equipment.
GearGuard Damage Waiver
Protects you from liability due to unintentional damage.
Theft not covered.
Theft not covered.
Reserved until : February 22?
The last reservation of this item will conclude on February 22. For rentals that require shipping or a pickup at a non-headquarter location, please select a later date for your arrival. Headquarter offices are the only locations that can accept a same-day reservation, as transit time is not calculated in this date.
The Pocket Wizard Plus II Transceiver is a radio triggering transceiver/receiver for remote firing of flashes and strobes. It can also be used to remotely trigger shutters with the appropriate Pocket Wizard motor cord (not included). It connects to your camera with either a sync cable (for rentals only – chosen at checkout) or via your camera's hotshoe. It connects to your flash or strobe by sync cable. Each Plus II is both a transceiver/receiver so they are interchangeable on your camera and strobe but you do need 2 Pocket Wizards for your off-camera strobe firing to work unless your strobe has a power pack with a built in receiver. This rental comes with only 1 Plus II. Two new AA batteries (not included) will run the Plus II for about 60 hours.
For more information on sync cable compatibility, see this guide.


text:
track list
Album The Great Hit Sounds of Dean Martin: That's Amore, Baby!
Label Jasmine Records
Released August 02, 2011
This site contains content from artists, fans, and writers from around the internet in it's natural form. Such content is not representative of Viacom Media Networks.
©2017 Viacom International Inc. All Rights Reserved. MTV and all related titles and logos are trademarks of Viacom International Inc.


text:
eCommerce/Multi Shops & Order Management Backend
- Status Closed
- Budget N/A
- Total Bids 18
Project Description
I will need my own multilingual, multicurrency, multishops system with a drop ship order backend system, covering:
- Suppliers
- Suppliers auto import managment
- Patner/Fulfillment
- Supply Chain Managemnt
- Multi Shops Managemnt
- Purchase Orders
- Sales Orders
- Order Status
- Stocks
- Clients
- Userrights
- Items
- Attributes
- Cross-Selling Items
- Item pricing system
- Autoimport of items form suppliers
- PDF Documents generation
- Paypal
- Moneybookers
- Invoice Payment
- and so on
- Newsletter System
- Support System
- and so on
- Received Orders for pick, pack and shippment
- Asked questions by clients that need to be answered
- Bidirectional communication with Admin about all issues that are related
- and so on
- Orders that will arrive with qty and date
- Orders that need to be re-shipped
- Invoice/Pro-Forma Invoice/Packlist generation
- and so on
CLIENT PANEL (of the multi shops)
- My open Orders
- My payed Orders
- Wishlist
- Invoices
- Profile Management
- and so on
- the latest standards
- Social Media
- and so on
- latest and modern developement and project management
- MySQL/Mongo DB
- JQuery
- YII Framework
- Multilingual
- Multicurrency
- etc
You need to be very experienced for this job and be working fulltime. No part/night shift job.
Skype chat and call is a must.Get free quotes for a project like this
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online