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Offering trusted performance at a wallet-friendly price, Black Diamond Women's Trail trekking poles offer innovative features rarely found on poles in this cost range. Easy-to-adjust external locks, extended length grips and aluminum construction combine to make Trail trekking poles a true bargain.
The Black Diamond Women's Trail Trekking Poles are the perfect balance between features, durability, weight and cost. The standout feature of these poles is the collapsibility. These are a telescoping three section pole. And they have two Black Diamond FlickLocks. These locks are really easy to us. As the name suggests all you need to do is flick them open with your thumb, adjust it to the proper height and flick them closed. It is as easy as that. There is no questioning of whether the lock is secure enough. It is just flick open and flick closed.
These are durable aluminum construction, but the weight is also pretty low for these poles.
Moving to the top of the poles you have really durable dual density foam grips. And the thing I really love about foam grips is that in warmer weather if your hands are perspiring this is really going to wick away sweat and it is not going to feel slippery or anything like that. And then in colder temperatures it doesn't feel cold though that foam. Also if you are wearing gloves, gloves grip really well on that foam.
At the top of the pole you have a nice flat surface. So if you need to you can palm the top. If you are going down hill or if you just want to use the pole in that way. And then below the standard grip you have an extended grip. It comes pretty far down the pole.
This is great for when you are hiking on uneven terrain, you don't want to make quick adjustments, but you just want to grab the pole at different lengths. It makes it really easy to just grab a hold of that. And then while we are up here at the top you do have a really nicely padded strap. It is a pretty thick webbing strap. So it gives you a lot of protection and it really cradles your hand really well. This is an adjustable strap. It is really easy to adjust. All you have to do is pull on the top to make it longer or shorter, depending on your preference and then it just takes that pressure off of your wrists as you are hiking.
Moving down the pole to the tip you have Black Diamond's flex tech tips. So this is a press fit tip. It is a replaceable piece, so if you are in the unlikely situation where you get this pole stuck between two rocks or in a position that might damage the pole, this tip is meant to break first before the actual shaft sections of the pole. That protects your pole and, like I said, it is a replaceable piece, so after years of use if you want to just replace this, you can buy a separate set and replace them.
At the bottom of this tip this actually is a carbide tip that is on there right now, but you can buy a rubber tip separately. And you basically just screw that off and screw the other one on. You can also buy tip protectors that go over top, but those are sold separately as well.
Right now I have a low profile basket that comes with the poles on it, but you can basically screw this off and put on a winter basket. There are threads on this tip so you just take this basket off and included with these poles is a winter basket. So that also adds a lot of value to the pole.
As I said, these are telescoping poles. So with the three sections I have this adjusted out to the maximum usable length which is about 125 centimeters, or about 49 inches. When you compact these down, they actually compress down to be pretty small. So they com-press down to be about 23 inches and the useable length here is from 100 centimeters all the way up to 125 centimeters. And that is what is different about the women's poles. They have a different range of adjustability. And because of that, they are a little bit lighter.
All in all these are a really great, durable, multi-use pole. They are easy to use with those Black Diamond FlickLocks and you get a lot of features, a lot of innovation for a really great price.
They are the Black Diamond Women's Trail Trekking Poles.


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Lets discuss the Evil Twins of Drinking!! Call in and tell us your worst experiences with the two! Also, Marley's Gotham Grill in Hackettstown,N.J. will be calling in to discuss there restaurant and Bar. Other guests as well and the PBR Challenge..Win some Beer!!!..Drink On!!
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About the awards
The Awards reflect and promote the aspirations of Wales and its citizens to be a modern, vibrant country, with a growing reputation as a confident and clever nation valuing innovation, community spirit, and above all its people.
They operate over the entire country - they are the "awards of awards" and the natural destination for all those who have won other sectoral or community awards.
The Advisory CommitteeThe Advisory Committee members for the St David Awards 2017 will deliberate nominations to recommend 3 Finalists in each category for consideration by the First Minister so that he may choose the winners. More about the advisory committee 2017
The Awards TrophyThe first, prestigious St David Awards trophy commission to have been awarded competitively was given to eminent artist and sculptor Gideon Petersen. More about the trophy
Awards Ceremony
23 March 2017
Senedd, Cardiff
Award categories
There are nine St David Awards. Each award is given in a specific category of activity and achievement, decided upon by the First Minister of the Welsh Government and his advisers.
Bravery Award
Citizenship Award
Culture Award
Enterprise Award
Innovation, Science & TechnologyAward
International Award
Sport Award
young person Award
First Minister's special Award
Bravery Award
This is an award for an individual or group in Wales who have demonstrated remarkable courageous behaviour or character: doing what is right in difficult situations. This may entail simple fearlessness or physical bravery and involves acting in spite of possible harm to one's self.
Citizenship Award
For an individual or group in Wales who, through their unselfish actions have served the public good. These could reflect "active citizenship" in which citizens have worked towards the betterment of their community through economic participation, public action, volunteer work, and other such efforts to improve life for their fellow citizens.
Culture Award
This is an award for an individual or group in Wales who have excelled in the arts and other forms of cultural achievement, expressed in any art form, language or medium.
Enterprise Award
This is an award for an individual or group in Wales who through their endeavours have achieved remarkable success in business. This may include the creation of meaningful employment for oneself and others.
Innovation, Science & TechnologyAward
This award is for an individual, group or research team in Wales who have developed techniques or solutions that meet new requirements and provided effective products, processes, services, technologies, or ideas that are available to society at large.
International Award
This award recognises any individual or group from Wales who have, through their work, personal prominence or influence, promoted Wales or who have made an outstanding contribution internationally.
Sport Award
This award is intended for an individual, team or group in Wales who have achieved or helped achieve excellence in the field of sport.
Young person Award
This award will be given to an exceptional and inspirational young person or group of up to 19 years of age in any field in Wales.
First minister's special Award
This award is in the personal gift of the First Minister - you cannot nominate for it directly. The award may not be automatically awarded annually and may depend on currency and relevance as well as merit. It could reflect collective as well as individual achievement. The recipient may be selected from one of the other award winners or may be selected independently of them.
The 2017 awards timeline
nominations open
nominations close
Short listed Finalists announced
St David Awards Ceremony


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Trump's weekend trips to Mar-a-Lago cost taxpayers millions
From CBS News: Budget watchdogs are criticizing the cost of President Trump's visits to Mar-a-Lago, his private club in Palm Beach, Florida. He has been there the past three weekends or 11 days of his 33 days in office. The travel has an estimated price tag of $10 million.
On Watch: Episode 8 – Welcome to the 'Cold Civil War'
Dear Editor/Broadcaster, Below, you will find the video/transcript for On Watch: Episode 8 – Welcome to the 'Cold Civil War' Transcript: I'm Chris Farrell . . . and this is "On Watch" Welcome to the 'Cold Civil War'! You studied the American Civil War in school. Some of you are old enough…
Judicial Watch to Represent Veteran Prosecuted for 'Posting' American Flag on Veteran's Affairs Center Fence on Memorial Day
The 74-year-old is also charged for taking photos of VA police (Washington, DC) – Judicial Watch today announced it will provide legal representation to Robert L. Rosebrock, a Vietnam-era veteran who faces federal criminal charges for displaying two four by six inch American flags outside a Veterans Affairs (VA) fence…
Judicial Watch president on Trump's new travel ban
From Fox Business: Feb. 20, 2017 – 5:16 – Judicial Watch President Tom Fitton on the legal hurdles President Trump's new travel ban may face.
Finding the Flynn leak
From The Washington Times: As WikiLeaks dumps of Clinton campaign and Democratic Party emails roiled the election campaign and put the suspicion on the Russians, the Obama Justice Department, it turns out, sought and obtained Foreign Intelligence Surveillance Court permission in October to conduct surveillance on former advisers to Mr.…
About Trump's 'Lavish Lifestyle,' A Small Reminder on How Much Obama Vacays Cost Taxpayers
From the Independent Review Journal: Reporters covering the Trump administration have revealed newfound curiosity about presidential travel expenses with stories of concern about the Trump family's "elaborate lifestyle … at taxpayer expense." The Washington Post, ABC News, CNBC, The Atlantic, and The Hill have all run reports on how the Trumps'
Judicial Watch Planning to Sue FBI, NSA, CIA for Flynn Records
Conservative foundation Judicial Watch is planning to sue several government agencies if they do not hand over records related to the wiretapping of former National Security Adviser Michael Flynn.
The group filed Freedom of Information Act requests for the records weeks ago but are planning to sue by next week for the records if they do not receive anything
Here's Why State Election Officials Think Voter Fraud Is a Serious Problem
From The Daily Signal: The panel discussed the pending voter fraud commission that President Donald Trump has said he would appoint, to be headed by Vice President Mike Pence. Trump has alleged that 3 million to 5 million illegal votes could have been cast in the November 2016 election, which…
Encrypted apps spark new questions for Trump-era workers
From The Hill: Conservatives have expressed alarm over the reports that new technologies might be used to evade records. Judicial Watch president Tom Fitton said that if the reports turned out to be true, he believes that White House staff using Confide to cover up leaks would be illegal and…
Judicial Watch: Federal Court Hearing on Official DHS Emails in Private, Unsecure Email Accounts of Former Secretary Johnson and Other Top Officials
Hearing set for Friday, February 17 (Washington, DC) — Judicial Watch today announced a hearing will be held on Friday, February 17, 2017, regarding Judicial Watch's Freedom of Information Act (FOIA) lawsuit seeking emails "relating to official United States Government business sent to or from" Homeland Security Secretary Jeh Johnson…


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Antix (video game)
From Wikipedia, the free encyclopedia
|This article relies largely or entirely upon a single source. (May 2010)
|Dmitry Pavlovsky
Vadim Gerasimov (effects)
|Elektronika 60, MS-DOS
|Release date(s)
Antix is a video game developed by Dmitry Pavlovsky, one of the original developers of the video game Tetris, and realized in 1985.".[1] The game was named Antix by Dmitry, what is short for Antixonix, because it was a version of a game Xonix.
The game has an inverted hidden play field.[clarification needed] It was first developed for the Elektronika 60 and then ported to MS-DOS by Dmitry and Vadim Gerasimov. Xonix was very popular at Dorodnicyn Computing Centre, where Dmitry was a computer engineer, and in Moscow before Tetris was made.
- ^ Gerasimov, Vadim. Tetris Story. Accessed December 30, 2007.
|This article about a video game released for MS-DOS is a stub. You can help Wikipedia by expanding it.


text:
21 - 40 of 62 Comments Last updated Feb 10, 2013
#21 Feb 7, 2013
Good. We don't need Olive Garden. At all.
#22 Feb 7, 2013
My cousin in Denver found not one but two coackroaches in her salad when she was eating at Olive Garden. She won $65,000 in the settlement.
#23 Feb 7, 2013
Olive garden is low grade dogfood.
#24 Feb 7, 2013
How do we know this is true? Just because they don't like that sight, they would bypass compoletly?
#25 Feb 7, 2013
The only thing that is good there is their salad dressing, and now, thanks to Pinterest, people can make it at home!
#27 Feb 7, 2013
I'm all for supporting local businesses but this poster has brought up some valid points. Everyone should try the OG and judge it for themselves and if you don't like it don't go back. And for everyone saying they will not go to OG, you will probably be the first ones there you just won't admit it.
#28 Feb 7, 2013
This is BS, you don't win that kind of money for eating a cockroach.
Think about it stupid, your life isn't in danger, you don't even get sick, just an inconvenience.
#29 Feb 7, 2013
Actually, you're pretty stupid. The poster said "settlement" not "verdict."
I do believe you work for a lawyer. Lawyers hire stupid people with no experience so they can pay $8.00 an hour with no benefits.
#30 Feb 7, 2013
The bid has already been given out to build. The design has already been approved. Will be starting in the spring. People in this area are a bunch of morons. The same people to complain will be the first in line. Lol losers. Utica Italian restaurants are all gone. Look how busy panera, moes, 5 guys, outback, 99, UNO , Applebee's red lobster etc. lol. Olive Garden is going to put a hurting on the locals. Btw Bella Cucina is gross. He has been trying to sell for years. He won't make it another year. Independents are a thing of the past in the utica area.
#31 Feb 7, 2013
It's probably worth $65k to Olive Garden to have that information not get out. That kind of thing can really ding a chain restaurant.
#32 Feb 7, 2013
I couldnt agree more with this post and Im not Italian either, but have been around. Olive Garden; come on. Do people around the country really think that is Italian food? I hope this place crashes and burns. There are more good Italian food restaurants in Utica then most of the north east. BTW Syracuse doesnt have any that compare to ones in Utica either.
#33 Feb 7, 2013
North Utica would have been good...
#35 Feb 7, 2013
they do have great dressing, its what brought me back after the first time I went there. The other food was ok but not something I would want on a regular basis. They did have some kind of chicken dish that was good, stuffed with cheeses, ruined that with mushrooms the second time I went so I quit ordering anything but salad after that.
#36 Feb 7, 2013
Frank Montecalvo wants free food or he will cry Strikeslip!
#37 Feb 7, 2013
This is new hartford not utica, we build new buildings and businesses while in utica more businesses close every year only to be replaced by another pizza place thats in and out within two years. if this was supposed to be built in utica and they backed down i would believe this rumor. so in two months when dirt is being moved and the foundation poured is it still not coming?? Oh and whoever keeps saying its going on burstone i suggest you save up 1.25 for a bus for your yearly vaction from east utica to the other side of the city and you might finaly give up that idea when you see dunkin donuts sitting in your future garden
#38 Feb 7, 2013
Truth hurts doesn't it?
Since: Jan 08
Location hidden
#39 Feb 7, 2013
I agree. I think Olive Garden tastes like cheap microwave pasta with red sauce. The salad is oily and bland and the soup tastes like warm dish water.
#40 Feb 7, 2013
#41 Feb 8, 2013
Good shit stain just don't go there. We don't wanna see your fat ugly face in the new eatery anyway.
#42 Feb 8, 2013
Call it what ever you want. It will be packed with people looking to dine in a nice environment. People looking for a little change of scenery. And oh yeah,the food is good too.
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Talk:August 28
|WikiProject Days of the year
--mav 00:11, 1 Mar 2004 (UTC)
Selected anniversaries for the "On this day" section of the Main Page
|Please read the selected anniversaries guidelines before editing this box.
August 28: Feast of the Assumption (Julian calendar)
The Battle of Jutand also wasn't 1914, and the author may not even have been thinking of Jutland anyway (I just left it in as Jutland as that was the only battle anywhere near there during that war). There was no full blown sea battle in that war before the Battle of the Falklands either, so just what engagement could there have been as early as August 1914? PML.
Moved birth from article:
Unverifiable. Lupo 11:35, 6 Apr 2004 (UTC)
Needs article[edit]
Gyula Várady Rklawton 18:21, 1 March 2006 (UTC)
Establishment of St. Augustine[edit]
I have removed the 1565 establishment of St. Augustine, Florida from this day. The article does not support such a statement, noting only that "Menéndez first sighted land on August 28". Pedro Menendez sailed back and founded the city on September 8, as the article notes. Please discuss here before changing it back. --Scaletail (talk) 16:57, 28 August 2009 (UTC)
Restoring Honor Rally - Glenn Beck[edit]
This event was one of the largest gatherings on the national mall with over half a million people present. Those on stage included Albert Pujols, Tony LaRussa, Dr. Alveda King, C.L. Jackson, Sarah Palin, SOWF, Marcus Luttrell, etc.
How is this not a notable event? It was a massive day regardless of the biases of those who intend on removing it over and over again. It makes no sense that it's large enough to have its own article, but not large enough to be notable.—Preceding unsigned comment added by Albert109 (talk • contribs) 02:14, 2 September 2010 (UTC)
- Where's the table of contents? As far as Beck goes, it's not the most trivial thing on the list. A lot of the other entries do not have their own article, although that may just be a sign of recentism. - Peregrine Fisher (talk) 03:43, 2 September 2010 (UTC)
A non-notable event would not have its own article. WP:JUSTDONTLIKEIT is not good enough to keep removing it with that bias Albert109 (talk) 02:35, 12 September 2010 (UTC)
- What evidence do we have that this event will have long term impact? Notability in this context is often not realized for years after an event occurs. Just because an event is notable enough for an article does not mean that it is notable enough for inclusion in a date article. -- Mufka (u) (t) (c) 02:07, 19 September 2010 (UTC)
Guess you guys are finally going to engage in conversation after 2 1/2 weeks of blatantly ignoring me and my questions as I tried to engage you as you deleted the postings of the Restoring Honor Rally as a "non-notable event". No concrete evidence, though the reintroduction of the Black Robe Regiment, the attendance of over 500,000 people, the gathering of big names, such as Albert Pujols and Tony LaRussa, Dr. Alveda King, Sarah Palin (like or dislike her), C.L. Jackson, Marcus Luttrell, Glenn Beck (obviously), Daniel Lapin, David Barton, etc., the focus of honoring the military, donating over $5.5 million to SOWF all seem like pretty big things to me. Oh, and the overwhelming media coverage leading up to and afterwards (MSNBC spent virtually all next week "dissecting"/bashing the event), being broadcast live from CSPAN AND Facebook to what I believe I heard was another 10's of thousands of people. And, for those who watched it or attended, the attempt by Glenn to focus the citizens of the country to continously be honorable and good people, <sarcasm> which would have absolutely no effect on how people operate in their daily lives and how they choose politicians. </sarcasm> This matters because his thesis is that we can't expect politicians/the system to change unless we ourselves don't change.
Albert109 (talk) 07:06, 19 September 2010 (UTC)
- What is the rush here? If this was such a notable event then history will make that clear. The Events section doesn't have to scoop anyone, and it's not intended as an exhaustive list of recent events. Most things in this section get added long after the event actually happened, and that works well. Political rallies happen all the time in this world, and so are rarely considered notable. It isn't obvious to me that this event comes under any of the criteria listed at WP:DOY, but time will tell. Note especially from WP:DOY#Standing the test of time When adding events to Wikicalendar articles, events should meet global notability standards for the foreseeable future. Events that are popular news items for a short period of time would not be considered long-term globally notable. Something that is newsworthy is not necessarily noteworthy. Winston365 (talk) 22:41, 20 September 2010 (UTC)
- (I changed the ref link you provided into an external link. I hope you don't mind. This page doesn't have a references section (nor should it), so ref tags don't work properly)
- A phone call from the Smithsonian requesting items (I don't know why Glenn doesn't mention which items, is it supposed to be a secret?) is not sufficient to establish the notability of this event. The notability guidelines can be found here, and there is certainly no mention of museums of any kind. This is unsurprising as museums and Days of the Year articles are completely different animals. The Smithsonian has a charter to collect as much as they can about the history of the United States, as it is a national museum. Days of the Year articles on the other hand concentrate on events that are globally notable. Winston365 (talk) 22:00, 23 September 2010 (UTC)
- Nope, don't mind - I don't even know the difference between the two ref and external link. At least you're enganging me unlike "Rlbarton" and "Mufka", who refused to discuss anything for over 2 weeks and acted like I was some vandal they can disregard. What you're saying makes sense even though I disagree at its notability. Albert109 (talk) 16:29, 24 September 2010 (UTC)
A year later the event almost forgotten. Relative to other things listed on this page its not significant. Just because it happend notable does not mean it has to be added. If people remember it a year from now maybe they will add it but I think it should be removed. (Baryaw (talk) 15:41, 29 August 2011 (UTC))
President Obama's Nomination?[edit]
The last day of the Democratic National Convention in 2008, he became the first African-American to receive and accept the Democratic nomination for president. Notable enough to be included? Mistrx75 (talk) 10:02, 23 February 2011 (UTC)
Which date of the race is correct?[edit]
There are many links that containing several different dates of the race between Tom Thumb and the horse. Wich date is correct August 18 1830 [2] [3] [4] or September 18 1830 [5] [6] or August 25 1829 [7]? Blast furnace chip worker (talk) 14:40, 26 August 2011 (UTC)
If August 25 1829 is not the date of the race then there is a mistake in Wikipedia here http://en.wikipedia.org/wiki/1829_in_rail_transport.
- This question has been put to several forum if you know the answer please reply on Talk:Tom Thumb (locomotive)-- PBS (talk) 21:48, 26 August 2011 (UTC)


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text: No recent wiki edits to this page. The "Deodato Studios" was created with Brazilian artists, partners of the artist Mike Deodato. In the team: Carlos Mota, Daniel HDR, Ed Benes, Emir Ribeiro, Mozart Couto and others. The artists of the studio had similar work to the Mike Deodato, and some these're brand new on comics works. In many projects credited for the studio, these artists had acted as pencilers and inkers. Later these artists had started to work alone with proper credit names on publications.


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As a longtime, loyal, and staunch defender of Chacacero I have to say I was a little disappointed today with my sandwich. I made the carnal sin of veering off my usual path and getting something different ---instead of the usual large chicken (which i usually save half of) I went for the large BBQ chicken. I have to say, I didn't like it all that much. I mistakenly thought the only difference was the addition of red peppers, with maybe a hint more of seasoning on the chicken. It's true, they do add red peppers. But they also (over) season the chicken. Instead of all the simple, basic flavors melding together to virtually "sing" in my mouth,--as they usually do --I felt like they were all competing with one another and there was just too much going on. I like spice, but the usual clean, sharp flavors of the sandwich seemed lost.
Do others agree? Is the standard sandwich the way to go? Or do others enjoy the BBQ? I think that'll be the last time I stray from my "usual," but I'm sort of bummed I was letdown...
Updated 2 years ago | 18
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I love my animals, and raise and sell miniature horses.
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Helping primary feel "primary"
View Single Post
Senior Member
Join Date: Feb 2011
Posts: 906
This whole primary/secondary might be easier to secure when everyone involved is relatively young and "unattached".
To me, having kids with person/people A instead of B pretty much shows you consider them your primary/primaries. Although I plan living with/close to Moonlight & co at some point, kiddies are definitely out of the discussion. Part of it is of course the fact that they have kids already, and I wouldn't want to create "competition" in a way. And the greater part is that because I consider Vanilla my primary, kiddies will enter into discussions with her.
But the love languages might help. If hers is quality time, indeed pointing out when he's made plans to hang out with her instead of you might work. Or if it's physical touch, then ensuring that whenever he passes her by, there is a embrace, a caress or a quick kiss involved. Words of affirmation maybe don't work for her so much, because I understand that he has told her already multiple times how he considers her his primary?
Me: bi female in my twenties
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text: November 18, 2014 by Ken Paynter CMS Online Learning Site Now Underway for Adult Learning Community and More! This year Cambridge Montessori School has quietly unveiled a new learning platform (currently entitled "CMS - Hope and Promise") which opens up many possibilities for our entire community of learners, young and old alike. It is built upon the open source software Moodle which is a vital and well-... » read more


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Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture. Only a small number of proteases have been identified capable of efficient processing of triple-helical regions of collagens. Several members of the zinc metalloenzyme family, specifically matrix metalloproteinases (MMPs), possess collagenolytic activity. A mechanistic understanding of the cleavage of intact collagens has been pursued for many years;the results of such studies could lead to the development of truly selective MMP inhibitors. Our laboratory developed triple-helical peptides (THPs) as MMP substrates, with the goal of using these models to dissect collagenolytic behavior and develop selective MMP inhibitors. In the most recent funding period of the present project (04/01/08-present), we have experimentally derived the initial steps of collagenolysis and identified specific residues involved in this process, quantified the roles of specific collagen residues in MMP substrate specificity, and developed selective MMP inhibitors based on secondary binding sites (exosites), and demonstrated the in vivo use of such inhibitors. Our studies also revealed intriguing, unexpected behaviors of collagenolytic MMPs, such as MMPs bind the triple-helix using slightly different orientations, one can use exosite binding THPs to inhibit some, but not all, proteolytic activities for a given enzyme, which could significantly reduce side effects, and substrate selectivity seen for single-stranded peptides is not observed in the triple-helix. The research plan described herein focuses on further development of triple-helical probes for teasing out collagenolytic MMP sequence specificities, identifying selective MMP inhibitors, and advancing the mechanism of collagenolysis. To achieve these goals we propose to (a) identify THP sequence preferences for the MMP family utilizing positional scanning combinatorial libraries, (b) design and characterize MMP selective, homotrimeric and heterotrimeric triple-helical transition-state analog inhibitors, and (c) explore the latter steps of collagenolysis usin state-of-the-art NMR spectroscopic techniques and design exosite binding THPs. Select inhibitors will be tested in mouse models of breast carcinoma and melanoma. Ultimately, we would like to obtain inhibitors that target those proteases implicated in cancers such as melanoma and breast carcinoma (MMP-1, MMP-2, MMP-9, MMP-13, and MT1-MMP) while sparing proteases with host-beneficial functions (MMP-3 and MMP-8).
The present study is designed to create a novel class of therapeutic agents to selectively stop the action of tumor-associated enzymes that degrade proteins (proteases). These proteases have been shown to be important for cancer progression, and thus blocking their function will impair the spread of cancer.
|Zhang, Xuan; Bresee, Jamee; Fields, Gregg B et al. (2014) Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo. Bioorg Med Chem Lett 24:3786-90
|Tokmina-Roszyk, Michal; Tokmina-Roszyk, Dorota; Bhowmick, Manishabrata et al. (2014) Development of a Förster resonance energy transfer assay for monitoring bacterial collagenase triple-helical peptidase activity. Anal Biochem 453:61-9
|Wang, Hongjie; Nefzi, Adel; Fields, Gregg B et al. (2014) AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein ?. Anal Biochem 459:24-30
|Zhang, Xuan; Bresee, Jamee; Cheney, Philip P et al. (2014) Evaluation of a triple-helical peptide with quenched FluorSophores for optical imaging of MMP-2 and MMP-9 proteolytic activity. Molecules 19:8571-88
|Lauer, Janelle L; Bhowmick, Manishabrata; Tokmina-Roszyk, Dorota et al. (2014) The role of collagen charge clusters in the modulation of matrix metalloproteinase activity. J Biol Chem 289:1981-92
|Onwuha-Ekpete, Lillian; Tack, Lisa; Knapinska, Anna et al. (2014) Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis. J Med Chem 57:1599-608
|de Castro Brás, Lisandra E; Cates, Courtney A; DeLeon-Pennell, Kristine Y et al. (2014) Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle. Antioxid Redox Signal 21:1974-85
|Chavaroche, Anais; Cudic, Mare; Giulianotti, Marc et al. (2014) Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition. Anal Biochem 449:68-75
|Fields, Gregg B (2013) Interstitial collagen catabolism. J Biol Chem 288:8785-93
|Cerofolini, Linda; Fields, Gregg B; Fragai, Marco et al. (2013) Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state. J Biol Chem 288:30659-71
Showing the most recent 10 out of 54 publications


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this wiki
|For more information, see Bigfoot on GTA Myths Wiki
Bigfoot, also known as Sasquatch, is an ape-like creature that some people believe inhabits the forests of San Andreas in Grand Theft Auto V. Bigfoot is usually described as a large, hairy, bipedal humanoid. It is very likely introduced due to the popular myth in Grand Theft Auto: San Andreas, which Rockstar Games confirmed to be fake.
Grand Theft Auto: San Andreas
Rumors of Bigfoot being found in Back O' Beyond surfaced within a week of the game's release. Although no definitive proof of Bigfoot's existence was ever produced and Rockstar Games eventually confirmed that Bigfoot did not exist in the game. However, they hinted something was there, which fueled many gamers to continue the search. However, the release of modifications made the search near-impossible, as anything considered "evidence" of his existence was most likely taken out of a modified version of the game. Bigfoot remains arguably the most popular myth of the GTA franchise. Possibly for this reason, Bigfoot was introduced in the next game taking place in San Andreas, GTA V.
Grand Theft Auto V
The mission's objective is to hunt the O'Neil brothers in the woods of Cassidy Creek using a rifle with thermal scope. At the lower right corner you can see Bigfoot standing still. He will immediately disappear after he has been spotted. If Michael tries to shoot at it nothing happens. This serves as an easter egg.
The Last One
The mission is dedicated entirely to Bigfoot. Franklin meets a hunter who says that he has been on a sasquatch's tail for eight years (GTA San Andreas had been released 9 years prior to GTA V). After searching the woods, the creature can be seen running. After a long chase, he will reach a dead end and will start cowering in fear. Upon shooting him, he will repeat the phrases "shoot me human" and "I'm the last of my kind" (This is a throw back to the sasquatch mission in Red Dead Redemption). Franklin concludes that the so-called Bigfoot is nothing more than a crazed man in a costume.
Golden Peyote
On the PS4, Xbox One and PC version, after the player beats the game to 100%, completes the Strangers and Freaks mission The Last One and finds all 27 Peyote Plants, seven special Golden Peyote Plants will appear, one in a different location for each day of the week, from 5:30 to 8:00 AM with the weather set to Snow (consoles, unlocked only by a cheat code) or Foggy (PC version). This special Peyote Plants grants the player the ability to play as Sasquatch himself. Bigfoot works almost identically to human characters, can drive any vehicles, can use any dropped weapons, and has increased strength. If the plants are eaten in order (from Sunday to Saturday), a dead animal, human or an abandoned car will be nearby. When eating the Saturday plant, the hunter from The Last One will lie dead next to the player, growling after this will cause a howl to sound from the distance, to which the player must follow, starting a hunt of sorts that consists on following a trail of dead bodies. Eventually, the player will arrive at Thomson Scrapyard and growling won't be available, then he should head to a small shack nearby where the very last body will be located, the camera will then zoom on top of a wrecked airplane, where the Beast will jump from, starting a fight. If the player wins, the hallucination will end automatically.[1] [2] [3]
- At the end of the Grand Theft Auto: San Andreas game manual, the name "Big Foot" is listed in the special thanks section.
- He appears on the city seal of Los Santos.
- In Red Dead Redemption: Undead Nightmare, one can get an achievement for killing a sasquatch called Six Years in the Making. This is a reference to Grand Theft Auto: San Andreas, as Red Dead Redemption was made six years after Grand Theft Auto: San Andreas.
- In GTA Online, a rare Animal Materials Crate can be purchased through the SecuroServ network for $25,000 containing a Bigfoot skin. It can be sold for $105,000.
- The Golden Peyote Challenge does seem to indirectly prove that the Sasquatch Role Player in the Last One and the Bigfoot in the Golden Peyote Challenge are different entities. This suggests that the Sasquatch Role Player is not the real Bigfoot, but that the Bigfoot from The Golden Peyote Challenge is indeed the true Sasquatch. This is also proved in the files as the Sasquatch Role Player identified as Orleans is a different pedestrian than the real Bigfoot.


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Mehrunisa Qayyum is the founder of PITAPOLICY Consulting. She tweets about politics, interests, technology and analysis in the "pita-consuming" region as @PITAPOLICY. Regarding international affairs and trade issues, she worked at the United States' Government Accountability Office for four years. Prior to that, she earned her MPP and Certificate in Contemporary Arab Studies from Georgetown University and a BA in both Near Eastern Languages & Civilizations and Public Policy from the University of Chicago.
Her recent writing experiences include analytical pieces on civil society, transparency & governance, human rights, political economy of Syria, and social media forums' impact. She enjoys watching the Colbert Report in her free time.


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Glass's, the publisher of used car price guides and other car market data, has called upon the government to extend its "cash for bangers" scrappage subsidies in order to avoid a damaging dip in demand when the scheme ends.
The company says that on current trends, the funds allocated to the scheme by the government to subsidise new car purchases will run out in October 2009, well before any expected sustained recovery in the economy. Higher new car prices and the ending of the temporary 2.5% VAT cut at the turn of the year are likely to choke off demand further. Glass's suggests that the scheme should also be altered to cover slightly younger cars, and vehicles standing on the nation's driveways without MoT certificates.
From the very beginning, the question of how to end the scrappage scheme without causing too much market disruption has been causing headaches. One alternative to the Glass's proposal that has been suggested by industry figures, is to taper off the incentives provided under the scrappage scheme, with any new tranches of aid providing support to new car buyers at successively lower levels.Reuse content


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March 26, 2001 - 9:00pm
For those HL owners using CS Mod, make sure to use the HL auto update utility (you can get it here on MG). I used this tool myself and it works very well - especially if you're not sure which patch you need.
Keep in mind that there will be no CS mod 1.2, it will go right to 1.3. CS Mod 1.3 and CS Retail 126.96.36.199 will be out in a few weeks, if not longer. Remember that these are the patches that will incorporate Valve's new Voice Communication technology and multicast spectator.
Half-Life: Counter-Strike v1.2 Release Documentation -- Readme.txt [6.30.01]
Changes/Additions :
- Added Deathmatch Classic
- New Automatic update system.
- Fixed GL texture binding problem (white skin bug).
- Optimized model drawing.
Add new comment
Cheat codes
Cheat codes Right click the games shortcut on your desktop, choose Properties, in the Target field add the following text: hl.exe -dev -toconsole. Then during game play press ~ (tilde) to bring up the console, then type in: sv_cheats 1. Press ~ (tilde) again, and enter one of the following: God mode /god Adjust gravity /sv_gravity <-999 - 999999> All weapons and ammo /impulse 101 Developer mode on /developer 1 Verbose developer mode /developer 2 Developer mode off /developer 0 Suicide /kill Map select1 /map No clipping mode /noclip Obtain item2 /give Opponents ignore character /notarget Third person view /thirdperson Return to first person view /firstperson Auto-reload enabled /+reload Auto-reload disabled /-reload Set reload speed; 0 is fastest, 3500 is default /rate <0-3500> Speak word /speak Speak sentence /speak See things brightly without flashlight /lambert -1.0001 Toggle light amplifier /r_fullbright <0,1> Strange colors and wireframes /r_fullbright 9 Toggle game speed /host_framerate <0,1> Spawn human grunt /impulse 76 HEV suit, weapons, and ammo /impulse 101 Spawns gibs and blood /impulse 102 Monster stats, while looking at monster /impulse 103 List global entities /impulse 104 Silent player /impulse 105 Model/sprite stats, while looking at target /impulse 106 Texture name, while looking at object /impulse 107 Control onscreen monsters /impulse 109 AI node information /impulse 195 AI node information /impulse 196 AI node information /impulse 197 AI node information /impulse 199 Spawn blood /impulse 202 Delete monster or NPC from world /impulse 203


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Gillespie won't rule out Yorkshire return
Jason Gillespie has left the door open for a Yorkshire return after agonising over the decision to leave England and move back to Australia with his family.
The county champions announced on Monday he would end his successful five-year spell as head coach at the end of the season.
"It's obviously been a very tough decision because I love my job," the former Australian fast bowler said.
"I'm standing down because of family reasons. It's well known that my wife and kids are now back in Australia.
"As much as I love this club, my job and living here in Yorkshire, the time is right to step aside.
"The initial plan was for the family to go back and spend a bit of time in Oz and then we'd all come back after the Big Bash and have another season at Yorkshire.
"Once it became clear that wasn't going to happen and the family was going to stay in Australia, the goalposts shifted a bit."
Gillespie, who spent two years with Yorkshire as a player, took over as head coach before the 2012 season and has transformed the county's fortunes, suffering just five defeats in 76 County Championship matches.
The 41-year-old has not ruled out a return to Headingley.
"I don't write anything off," said Gillespie, who has a part-time role with Big Bash League side Adelaide Strikers.
"I love this club and have enjoyed every minute of it.
"Who knows what will happen in the future? I wouldn't say no moving forward, but at the moment the time is right to spend some time with my family."
Yorkshire secured an immediate return to Division One in Gillespie's first season in charge.
After finishing second in 2013, they won back-to-back titles despite continuing to lose key players to England.
The county are only five points behind leaders Middlesex in this year's title race and face the prospect of attempting to secure a hat-trick of championships at Lord's in Gillespie's final match in charge.
"I think it would be fitting for everybody (to win the County Championship again)," said Gillespie, whose side take on Hampshire in Southampton from Wednesday.
Director of cricket Martyn Moxon admitted it was a decision Yorkshire had seen coming.
"It's news we'd always feared," he said. "He's done a brilliant job here.
Moxon reiterated Yorkshire's desire to wait until the end of the season to start their search for the next head coach.
"We will think about Dizzy's successor, of course, but our real energy will be making sure we give the lads the support they need during the last four games.
"The reaction from the lads was they wanted to send Dizzy out on a high."
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I hardly ever write a review and I feel really bad writing poor ones. However, It's time to step up the game. I'm a business owner as well and if my hotels maintenance was not up to par I wouldn't be making any money. Our heater did not work in our room at all. I let the front desk know...
1st stay after years of going to Helena. I needed a reasonable price immediately and was surprised to be so well accommodated by the manager, Shelly. The building is straight out of the 60's and the interior is very western. Everything is well kept and clean. The staff I had interactions with were extremely friendly and helpful. There is always...
Yes this is an older hotel, but you can see that they are making upgrades! I as a business traveler see this all the time. I also understand that the owners have NOT usually WON the lottery, so it takes a lot of time and money to bring things totally up to date overnight! My room was very clean and...
Nice hotel. Rooms were clean and spacious, and the staff was very nice and easy to deal with. A good buy for the price and location. There is a casino in the bottom floor, but noise and smoke were never an issue.
The hotel is old and needed refurbishing but probably a rebuild would be cheaper. Excellent location and easy to find. It was clean but the pillows smelled stale. The bathroom fan ran all the time so we kept the door closed at night. Staff were friendly and helpful.
It is an older hotel, and a little tired, but the rate charged reflects this. It was the only hotel in a $70.00-120.00 range that had rooms. Not bad a pinch.
"Rooms on top floor (3rd) are quiet, with a nice view."
"It does have an elevator for people like me using a wheeled walker."
"The doubles have great view of the sleeping giant mountain"
"3rd floor is super nice and quiet at night"
"At the other end of the building would be good."


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Yacht Name: Plan B
Yacht Length: 73 m (240 ft)
Guests: 16 in 8 cabins
Crew: 22 in 10 cabins
Yacht Value: US$ 125 million
Owners Name: Ted Waitt
Ted Waitt Net Worth: US$ 900 million
Owners Company: Gateway
Owners Country: USA
Either Gateway founder Ted Waitt or Russian billionaire Patokh Chodiev owns the yacht Plan B
The yacht Plan B was built in 2012 by Abu Dhabi MAR Kiel (formerly HDW). She was part of a pre-
Ted Waitt seems to be the owner of the yacht Plan B. In 1985 Ted Waitt and Mike Hammond founded Gateway. Gateway Inc is a computer hardware company which develops, manufactures, supports, and markets a wide range of personal computers, computer monitors, servers, and computer accessories. It was famous in the 1990's for shipping its hardware in in cow-


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Scoop by Michael2.
- Recommended by dbz77
- Synopsis: A reporter goes to Macross City to cover the launch of the SDF-1
- Recommended by SAMAS
- Synopsis: Decades after the events of The Shadow Chronicles, a discovery hidden within Charon once again changes the course of Human History. Crossover with Mass Effect
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- Pairings: Roy/Claudia, OC/OC
- Synopsis: Eight years after the crash of an alien spaceship, a new prototype aircraft is being tested on a base located at the crash site. Follow the story of one of the test pilots, and those around him.


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Apu Nahasapeemapetilon is a legend of Indian cinema.
Sort of.
Over the past eleven years, several Simpsons characters have made their way into the zeitgeist--several of whom are minority characters. But rather than being vilified, Apu has been claimed, somewhat lovingly, by Indian convenience store owners everywhere. How do I know? In December of 1989, the year The Simpsons hit the small screen, my family packed up our lives and moved north, to own and operate a Food Store.
Apu makes owning the Kwik-E-Mart look easy. Running a convenience store in real life is hard work - early mornings, late nights, few holidays. For the three years my parents had "the shop", they were up before dawn and in bed after midnight. Back then, Indians weren't the majority of convenience store owners--in Australia, anyway--and Apu meant nothing to any of us. For my brother and me, the shop was fun--we chased each other with pricing guns, ate far too much ice cream out of the sales case, and lounged in the fridge half-heartedly stacking milk on hot days. When my parents sold the shop in late 2001, we cried.
But my attachment to our family Food Store dwindled as Apu's popularity skyrocketed. Where I once related funny stories--the lady who bought her dog ice cream every day, and let him lick it directly out of the package, the time we trolley raced around the aisles in socks and nearly took out a Coke display--I now kept my mouth shut, and my family's history as Apus a secret.
Despite my marvelous secret-keeping abilities, Apu's catch phrase still haunted me. Every time someone learned I was part Indian (my husband included), they'd immediately shout, "Thank you, come again!" At first, I gritted my teeth but let it slide. But by my second year of university, I'd had enough. Whenever someone greeted me with the dreaded phrase, I'd launch into a lecture on stereotyping and racism. Soon, though, my lectures devolved into fist-curling rants--
"Do you know how racist that is? Not all Indians are shopkeepers, and even if they are, they do not all say 'Thank you, come again' like they just got off the damned boat! And furthermore, we don't only eat curry in a hurry, and I hate Bollywood musicals!"
Unsurprisingly, the rants didn't help. They just made things worse. Some days, all I wanted was to punch something, but I couldn't afford it. My dorm charged a 200% cost-of-replacement fee.
Sometime while I was at university, my uncle and aunt moved up to the coast, settling near my parents. Within a year, they bought a convenience store. At first, I was appalled - how could they encourage the stereotype? How would their kids cope with the constant Apu-baiting? But neither my cousins nor my chacha and chachi cared about the stereotype. In fact, they embraced it, my uncle going out of his way to say "Thank you, come again," to white customers in a just off-the-boat voice. When I asked him about it, he shrugged.
"Why does it matter, Peta? It's just a bit of fun, and it makes them laugh. And if they laugh, they might remember me when they need something, and come back in, and I'll make a sale. And then I'll say it again, and it'll start over again."
I, being 18 and in complete understanding of the universe, gaped in a most unladylike way. "But they're laughing at us! And you're letting them!" My chacha shrugged again. "They're only laughing at us if we're not laughing, too. And Apu is pretty funny." Putting on a silly grin, he did the Indian head bobble, and said the dreaded phrase again. This time, it didn't bother me so much.
Today, I still don't say it, even when asked (yes, people really do ask). But I don't steam up either, because, as much as I hate the idea of stereotyping, Apu has given NRIs a safe, easy way to connect with non-Indians and find common ground. Now, when someone hits me with the t-y-c-a bomb, I smile, then ask how they liked the latest episode.


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Welcome to OCCGS!
The Orange County California Genealogical Society (established in 1963) is a non-profit, educational organization in Huntington Beach with 400 members. Its purpose is to collect, preserve and disseminate knowledge and information in regards to genealogy and related historical, biographical and heraldic data. It strives to instill and promote interest and instruction in genealogical research. OCCGS provides full maintenance and development of the Genealogy Collection housed at the Huntington Beach Central Library (lower level), which now contains over 20,000 volumes. You can access the H.B. library system by clicking on Huntington Beach Public Library.
OCCGS is proud to present...
A Day of DNA with CeCe Moore
Saturday, March 4, 2017
Huntington Beach Central Library
Visit the OCCGS Affiliates page to learn more about supporting OCCGS!


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The D-Link DHP-500AV is a powerline network adapter that brings up to 500Mbps speed to your home network. It uses existing electrical outlets and powerlines within the house as network wiring and ports. The DHP-500AV supports AES encrytion for security as well as simple plug and play setup. It is backward compatible with older generation Homeplug AV certified products. Whilst the theoretical 500Mbps network speeds sounds ideal, the actual speed is dependent on your home's wiring quality. That said powerline adapters are a good option for buyers looking to extent their home network to parts of a building where the wireless signal might not be ideal.
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CeceliaGross: It is the advice of carpet manufacturers that carpets be cleansed a minimum of once a year so as to stop them from carrying out untimely. once puzzling over your health and also the health of your family, a routine Woodland Hills Carpet Cleaning becomes a necessity. Except for the ever gift germs and bacterium that may settle deep inside carpet fibers, carpets area unit a number for variety of unpleasant odors. To eliminate germs and odors, frequently regular cleansing may be a best apply.Professional carpet cleansing corporations have already got this type of apparatus and cleansing product accessible, and that they will save home and business house owners an excellent deal of your time and energy. Most skilled Carpet Cleaning Woodland Hills companies will have your carpets clean in an exceedingly matter of hours in order that you'll quickly retreat to to try to toing no matter you wish to do in your home or workplace.
Friday, October 30, 2015, 12:34 am


text: Posted January 3, 2002 Hello, My name is Jane. I was a classical ballet student as a child and an Aust Ballet subscriber as an adult. I was hoping someone could help me. Does anyone know what Gelsey Kirkland is doing nowadays? Is she OK and enjoying life or is she teaching or maybe doing something else totally removed from dance??? Thank you for your time, Jane Share this post Link to post


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Circuit de la Sarthe
Zytek Wins At Le Mans
Six lap victory in 24-hour race's LMP2 class
Zytek took an emphatic LMP2 class victory at this weekend's Le Mans 24-hours. The Greaves Motorsport entered Zytek-Nissan Z11SN of Karim Ojjeh, Tom Kimber-Smith and Le Mans newcomer Olivier Lombard won the category by a massive six lap margin. It was first time one of the Repton-based manufacturer's racecars had been victorious in the world-famous race although its V8 engine powered the LMP2 victor here in 2007.
To underline Zytek Engineering's success, the Greaves Z11SN was powered by one of the Zytek Engineering developed and serviced Nissan VK45DE engines. These were introduced following this year's change to production-based units for LMP2.
Karim, Tom and Olivier led the class from the 11th hour, one of the three Nissan/Zytek engined cars that dominated LMP2 for much of the race. Following Zytek's own chassis in second place was the Signatech Oreca-Nissan of Soheil Ayari, Franck Mailleux and Lucas Ordonez. At one point in the race the Nissan/Zytek-engined cars occupied all the top three spots in class. The Greaves Motorsport entry also finished in eighth place overall beaten only by the larger cars of the LMP1 class.
"It was a great result for the team," said Tom. "They've worked really hard. The car ran faultlessly – no issues, no punctures." The only moment of concern came towards the end when Tom was caught out by the greasy conditions caused by light rain, spinning into the gravel at the Dunlop curves. By this time the Zytek's lead was such that it hardly mattered. Tom also praised his team-mate Olivier Lombard. "He only sat in the car last week," he pointed out. "It has been extraordinary for me to win at Le Mans aged 20," said Olivier. "I have to thank the team for its confidence in me."
For Karim, it was the culmination of a long and determined campaign to win at Le Mans. "It's like a university degree," he said. "There are some things that can never be taken away from you."
-source: zytek


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> I've been trying to keep the house
> at 59 to offset the incease in the price of gas heat.
Kitty, that is the temp we have been maintaining except in the eve when we
are usually, at least my husband, sitting.
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Defeated Creek Campground has 155 sites with electric and water hookups, 63 sites have sewer hookups. Also: Six-mile Bearwaller Gap Trail. Bike trail, hot showers, swimming beach, boat ramp, playground, marina, and two picnic shelters.
Tennessee Vacation eGuide
The 2016 eGuide gives you instant access to Tennessee's irresistible attractions and destinations. Peruse venues online, then put in your order to get a free guide delivered to your doorstep.


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Prince of Persia:Sands of Time - (Region A Import Blu-ray Disc)
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"In the spirit of the Pirates Of The Caribbean trilogy, Walt Disney Pictures and Jerry Bruckheimer Films transport you to the mystical lands of Persia for this wildly entertaining, epic action-adventure. It's a race against time when a rogue prince (Jake Gyllenhaal) reluctantly teams up with a rival princess (Gemma Arterton) to safeguard a magical dagger that gives its possessor the power to reverse time and rule the world. Filled with death-defying escapes and unexpected twists at every turn - Prince Of Persia: The Sands Of Time is a fun-filled adventure that will keep your pulse pounding long after the credits end."
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- 786936787566
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- Prince of Persia:Sands of Time - (Region A Import Blu-ray Disc)
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- Buena Vista Home Video
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- 116
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Trouble Every Day is Claire Denis's most disliked film. Even among her ardent fans, the feature is often seen as something of a failure (unless, of course, they happen to be one of the movie's few, fervent supporters). I, however, fall somewhere in the middle; I acknowledge its many flaws, but can't shake its haunting visuals. I'm consistently drawn to this bold material: an erotic parable which imagines a world where a certain group of afflicted individuals engage in sex as foreplay to violence; a predatory process which awakens in them an intense primal urge to attack and kill their partner (taking rough sex to a whole new level).
The idea for the film began with a nightmare the director had when she was a child, wherein her mother's goodnight kisses morphed into vicious bites. This concept — the fine line between lip and tooth — manifests itself right at the outset, when a couple is seen making out in their car, scored by Stuart Staples' (of Tinder Sticks) tension-racked orchestration, establishing dread and suspense that would normally give way to some kind of brutal action. But this is not a traditional horror movie, and such violence doesn't take place at this time. Denis understands that patience is a bedfellow of suspense, and fulfillment comes later.
While making a short film in New York City, a friend of hers in the industry asked Denis if she might be interested in making a genre film. Her response, many years later, is Trouble Every Day, which is in many ways not a genre film at all. It bears resemblance to various vampire movies, and the director claims that she's always been interested by that particular creature's mythology, but she hesitates to count her film among those that explore it. And understandably so; there's a brutality of an entirely different persuasion in Trouble Every Day. Sucking blood is not so much the motivation here; instead, the afflicted are prone to ravaging the bodies of their prey with a primal urgency, spattering the screen with blood. Not gore, however, which is an important point to make, as Denis claims (and I'm inclined to agree). The director makes no apologies for the blood in her films, but she insists that there is no gore, and that the term implies a certain "nihilism" which her film does not posses.
At first, "nihilistic" struck me as an accurate way to describe Trouble Every Day, as its bleak vision of an alienated people living with very little hope of a normal life suggests. But, upon further examination, to designate it at such is to overlook the love shared between these characters. Core (Beatrice Dalle), for instance, is possessed by this bizarre malady and cared for by her handler, Leo (Alex Descas), who's also her husband. The heartless way in which Leo unleashes his wife on unsuspecting victims (a chilling introduction to both characters) is given further dimension through an undercurrent of melancholy, evidenced by regret written all over Descas' face. Leo is not an evil man; he's a desperate one, obligated to carry out this horrifying procedure to keep his wife alive. Similarly, the relationship between the infected Shane (tall, dark and creepy Vince Gallo) and his new wife June (Tricia Vessey) is one of great affection, and their on-screen romance contrasts that of Leo and Core. The latter two find themselves disassociated from each other, accepting the inevitability of their circumstance, and living selfishly. Shane, on the other hand, represses his violent urges, and fights his condition in hopes that he can have a normal life with his partner.
Much of the film is devoid of dialog, as is the case with many Denis films, placing emphasis on tone and atmosphere — again, nothing new for those familiar with the director's unique brand of storytelling. But, unlike Denis's best films (Beau Travail, The Intruder), the plot which emerges here is needlessly confusing and distracting: something involving Leo (who's apparently a scientist of some kind), his involvement with Shane, and the research both have done in effort to cure this debilitating disease. The specifics are left vague, and an attempt to establish a preexisting relationship between Shane and Leo's wife, Core (they were perhaps once lovers) is headache-inducing. And yet, as much as this unintelligible plot does serve to dilute the purity of Denis's visceral cautionary tale — one far more chilling than, say, Basic Instinct — it's the intrigue this concept commands that makes the film compelling.
Emotionally charged sequences, shot sublimely by the reliably brilliant cinematographer Agnes Godard, burn into the memory. These include basically every tense moment and longing glance shared between Shane and June, who yearn to connect with each other so completely that Shane occasionally forgoes caution, and gives in to temptation; only to be stifled by a mark on June's shoulder, reminding him of past transgressions and of his own limitations. Scenes like this perfectly encapsulate Denis's thematic concern — dangerous love. As such, Trouble Every Day becomes so much more than a "hysterical yet humorless disquisition on the thin line between sucking face and literally sucking face," as one critic naively has described it. It's a movie which concerns itself with the relationship between allure and danger, asserting its theme forcibly, with every lustful glance and pining gesture. Some may find this approach too subtle, preferring that the director lecture us and present us with some kind of metaphorical iteration (a filmmaker less trusting of their audience may slap on a narration to drive the point home, something like, "a rose is gorgeous, but it has thorns").
Trouble Every Day is all about inaction, and so most horror enthusiasts will likely be repelled by the quiet moments, which make up the majority of its runtime. However, this sparseness is necessary, as it enables the two instances in which violence does take place on screen to be all the more jarring. Both these sequences are nearly unwatchable in their unrelenting brutality, and will likely disturb the viewer more than anything that, say, the Saw franchise has to offer. Which is why, thankfully, they are used sparingly — as exclamation marks, not sentences — and so I find them to be necessary evils that elicit the reaction required to understand this particular piece of art on its own terms. They're not entertaining or even titillating (both take place during sex). They're sadistic, but they serve a purpose: cautioning the fulfillment of lustful desire.
An agreeable tone is established early on, and the movie effortlessly coasts by for much of its duration. Staples' soaring strings, tapping percussion and shakers score panning shots of skin, photographed by Godard like the rosiest of apples; as seductive to the viewer as to predators like Shane and Core. Like many of Denis's films — though, admittedly, more fascinating here than anywhere else in her oeuvre — the role that skin plays is intrinsic to the narrative. Not only is it shot to look delectable and inviting, but it's treated as delicate and easily damaged; the thin layer of protective coating separating the afflicted from their sustenance. In fact, the film's power of suggestion, and its effectiveness as an allegory, make it hard to admit its many and glaring flaws.
At its least effective, Trouble Every Day feels over-thought (not a common attribute of a Denis work), and far too literal (ditto). The worst scenes tend to involve Leo and his many bizarre experiments. When the plot shifts into mystery/procedural territory towards the end of the second act, its overly scientific preoccupations (talk of neurological disorders and brain samples in Petri dishes) fly in the face of the narrative's more naturalistic progression, and the almost innate, animalistic behaviors of these characters. It's occurred to me that Denis may be trying to make some kind of statement on the futility of man-made serums and scientific solutions in combating basic human nature, but if that is the case, her argument is both vague and abstract.
Despite all of this, Denis overcomes, and delivers a thesis both controversial and undeniably thought-provoking: the director posits that all desire — sexual, violent, or otherwise — is intrinsically linked. Just as blood and skin are the same (part of our DNA), carnal urges are equivalent to violent urges, and the two exist on the same plane of fulfillment. The separation, essentially, is defined by an individual's own ability to control their actions in the heat of the moment. It's a theory which virtually no "genre" films would have the audacity to suggest, and I can think of few concepts more terrifying.Powered by Sidelines


text: Seller: suzie2607 (3,108) 99.7%, Location: Doncaster, Ships to: GB, Item: 371798034080 i have for sale a super antique early 20thC light oak swivel desk chair. it really is a lovely light colour with a good solid base and height adjustable. it measures 45cm wide 43cm deep dn 90cm total height 99p start and no reserve i will be listing lots of fabulous antique items on sunday evening all with a 99p start and no reserve I have a special rate with a local courier which allows me to offer their Economy delivery service on this Item of just £38.00 delivery within a 30 mile radius or £55.00 incl. vat anywhere the mainland uk with exception of remote and highland areas where you will have to email with a postcode before bidding for a price .Collection is available from DN5 0LNPlease allow 14 - 21 days delivery from order date. The couriers collect from me once a week, they are a small family firm that specialise in careful transportation of furniture. This is a one man service therefore assistance must be supplied at delivery address. All my Goods are described as accurately and honestly as Possible, (please view my feedback ). The item you are buying is always the item pictured, but it is virtually impossible to 100% portray the colours of the item in a picture on the web, colours can vary and such things as your monitor's screen resolution can effect shading. Returns will be accepted solely at my discretion if there is a significant flaw that was not clearly stated on the listing prior to purchase. I therefore ask you to read all my descriptions carefully and study the extensive photography before placing your bid. Please note that although i have chosen the carriers, the fees paid for delivery are forwarded to the carriers and are non refundable. It is also the buyers own responsibility to arrange, wrap and pay for any returns.Thank you Condition: see description, Age: 1900-1950, Material: oak, Brand: unbranded, Product Type: desk chair, Original/Reproduction: Original