text:
Welcome to New Jersey @ Jonathan LeVine Projects
Welcome to New Jersey is Jonathan LeVine Projects' inaugural exhibition in Jersey City featuring works by the following artists: Adam Wallacavage, AJ Fosik, Alessandro Gallo, Alex Diamond, Andy Kehoe, Ashley Wood, Augustine Kofie, Beth Cavener, Camille Rose Garcia, Carlos Ramirez, Chloe Early, Cryptik, Dan Witz, Diego Gravinese, Dylan Egon, Eloy Morales, Erik Jones, EVOL, Gary Taxali, Handiedan, Haroshi, Hush, Jeff Soto, Jeremy Geddes, Jim Houser, Joel Rea, John Jacobsmeyer, Josh Agle (Shag), Kazuki Takamatsu, Mab Graves, Martin Wittfooth, Mary Iverson, Matt Leines, Matthew Grabelsky, Michael Reeder, Miss Van, Nychos, Phil Hale, Ron English, Shepard Fairey, Tara McPherson & Tristan Eaton.February 17, 2017
American Civics @ Subliminal Projects
American Civics at Subliminal Projects in Los Angeles features the first-ever collaboration between Shepard Fairey and the estate of legendary photographer Jim Marshall. The exhibit will showcase Fairey's interpretation of Marshall's iconic photography from the 1960's with mixed media paintings on canvas, large format serigraphs, handcut rubyliths, works on wood and metal, as well as Jim Marshall's original photography. The exhibition will also include a collection of artworks by Shepard Fairey inspired by the current political climate.January 20, 2017
Shepard Fairey and Little Lions EP
Shepard Fairey goes all 'Smooth Criminal' (minus the dance moves) in the first video for his musical venture, NØISE on his own Obey Records. The original 'Little Lions' track is a couple years old, but now has a proper EP release with some headliner - name remixes from Tim Armstrong and Z-Trip, among others.November 01, 2016
Shepard Fairey Champions the Legend of Jim Marshall
Think of pivotal cultural moments of the mid-twentieth century and know that Jim Marshall documented those imprints. From Woodstock to civil liberties, Bob Dylan to antiwar protests, Marshall's photographic legacy has helped younger generations put these crucial, iconic movements into context. This summer, beginning with a special showcase in Washington, DC to benefit the NAACP Legal Defense and Educational Fund, Shepard Fairey and the estate of Jim Marshall will collaborate on a series of five new pieces that champion Marshall's work on the issues of voting rights, mass incarceration, workers' rights, firearm ownership, and a fragmented America. We asked Shepard to speak about one project in particular, the incisive examination of gun culture.August 10, 2016
RFK Mural Festival in Los Angeles
Branded Arts presents the Robert F. Kennedy Mural Festival hosted at the RFK Communitiy Schools in Downtown LA. Contributing artists like Shepard Fairey, Jeff Soto, Sam Flores, Greg Mike, Risk, Cyrcle (and around 30 others) began working on pieces this week for an exhibition on May 27.June 06, 2016

subset: commoncrawl


text:
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it...if it works you get control of your gardens back from the lil
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--Albert Einstein
--- On Tue 07/13, < firstname.lastname@example.com > wrote:
From: [mailto: firstname.lastname@example.com]
To: email@example.com
Date: Tue, 13 Jul 2004 09:27:15 EDT
Subject: Re: [CHAT] self-sowers
In a message dated 7/12/04 11:28:01 PM, email@example.com
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Chasing It Girls at FIT
What is It? What is that indefinable, magical quality shared by Clara Bow, Brenda Frazier, Edie Sedgwick, and Paris Hilton? You're asking us? How should we know?
We're sitting on a velvet ottoman in a practically pitch-black gallery at FIT and, whatever it is, we're pretty sure It is right up there in front of us, in the form of a dipping, swirling dancer named Irene Castle. Castle, practically weightless in layers of pale chiffon and with her famous bobbed hair concealed under a Dutch-girl hat that one suspects she alone could get away with, is cake-walking her heart out in a 1915 movie called The Whirl of Life.
Excerpts of the film are screened in a continuous loop at FIT, in conjunction with "Designing the It Girl: Lucile and Her Style," a show dedicated to the art and life of the once-legendary Lucile, who designed Castle's gossamer frocks along with exotic ensembles for various other early-20th-century celebutantes.
Castle herself was the undisputed It girl of the World War One era, and is generally held responsible for convincing a generation of women to lose their Edwardian locks; Lucile (1863-1935) in addition to being a hot designer, was also a sort of nascent lifestyle guru, coaching nouveau riche debs in the acquisition of proper deportment, social graces, and the always hard to pin down "personal style." If they were really apt pupils, Lucile's charges might aspire to what her sister, the wildly popular novelist Elinor Glyn, termed "It" a coinage that has come down to us unchanged, in all its frisky glory, almost 100 years later.
Upcoming Events
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TicketsSat., Feb. 25, 7:30pm
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This Lucile had quite a history: She went from cutting out patterns on her dining room table to designing couture to surviving the Titanic to becoming Lady Duff Gordon to making clothes for the Sears-Roebuck catalogue. Her retrospective is one of three fashion exhibits currently at FIT, and for a proto-flapper like us, it's perfect heaven.
Not that there's anything wrong with the other two shows. Downstairs, a large room is devoted to "Glamour: Fashion, Film, Fantasy": a trove of evening gowns from a 1755 robe la francaise to a startlingly accomplished frock by the bohemian As Four, circa 2003. A fair number of garments have Hollywood provenances, and it's a joy to see Harlow's skin-tight satin from Bombshell and even giddier to behold the notorious, nearly transparent bell-bottomed Scaasi get-up Streisand wore to accept her Oscar in 1965. The exhibit is sponsored by Target, which at first seems hardly synonymous with glamour, but then again, if Lady Duff Gordon can end up with Sears, why not?
The third show is devoted to the late German illustrator-photographer Rico Puhlmann, and begins with a wealth of his fashion drawings done for Berlin newspapers in the 1950s, when the German fashion industry was slowly reviving. Later, Puhlmann moved to the States and for years was responsible for the look of Harper's Bazaar. His most riveting works are his depictions of women sporting trapeze coats and pillbox hats, posing elegantly in front of the Brandenburg Gate or sauntering along the Seine. Puhlmann's pictures from the 1960s are especially poignant: For him, this is not an era of matted hair and gypsy velvet, it's a decade of Jackie O. and sleek, spare tent dresses, which in retrospect seems as lost and elusive as Lucile's brand of glamour.
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Sponsor Content


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The Horse Forum (http://www.horseforum.com/forumindex.php)
- Horse Pictures (/horse-pictures/)
- - Horse Appreciation Day :D (9/17/11) [Picture heavy] (http://www.horseforum.com/horse-pictures/horse-appreciation-day-d-9-17-a-98486/)
Horse Appreciation Day :D (9/17/11) [Picture heavy]
Every year the Pasadena Horse and Pony Association (PHPA) hosts Horse Appreciation Day at Dublin Farm. This year's HAD was dedicated to the BO who lost her long battle with breast cancer earlier this year. Mostly everyone wore pink to show their support to the family.
I'd thought I'd share some pictures!
There were pony rides, farrier demonstrations, jumping demos, dressage demos, western pleasure vs. english pleasure demos and a bunch more.
Me and Jordyn (reveriesgirly) participated in most of the events (even the western ones too haha!) and it was a blast. :) Me on Cowboy, and Jordyn on Kinbally. (Cowboy is the chestnut, and Kin is the dark bay)
Afterwards we went to my highschool, which is right across the street, and just galloped around the fields in the back, it was so fun..the last pictures of when Cowboy stopped and made me slide off lol, at a gallop mind you haha! (:
Warming up!
Lol, I love making funny faces XD
Getting ready to ride for the parade of breeds
Parade of breeds! (Don't wanna post any pictures of other riders)
Bucking haha..
Shaking My Head Cowboy!
Kin jumping!
Doing poles and barrels, english style!
Kin doing poles
Fell off in the field lol..
Like I said in my first post, we lost Dublin's BO earlier this year. To wrap up this year's Horse Appreciation Day, Katie Holt, the new BO of Dublin, rode Mrs. Gail's horse as people took turns telling stories about her, it was a bittersweet moment, and may she rest in peace.
Gail bought Dublin about 14 yrs ago and when she met him, it was love at first sight. She named her farm after him. Katie soon began riding him and it was an instant connection too. Here are the pictures of the ending!
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text:
Art Print
Alcatraz Islandby Elizabeth Tompkins
Collect your choice of gallery quality Giclée, or fine art prints custom trimmed by hand in a variety of sizes with a white border for framing.
Preserved today as a National Historic Landmark located in the San Francisco Bay is Alcatraz Island. Also known as The Rock, Alcatraz used to serve as a military fort and prison before it became the federal prison it is most known for. The island housed the country's most notorious criminals before shutting down in 1963 due to the high cost of upkeep and insufficient funding.


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3 Days in New Delhi
Shopping Guide for New Delhi
New Delhi Off the Beaten Path
So far the coolest hangout place in town. Loved the Indian food and they had so much varities to offer. Best desserts too. The ambience is to die for. Lovely.
Nice restro bar. Amazing cocktail served by the bar tender. Had went in afternoon with some team members for a quick mean . Good food good staff .Must try when in Delhi
Awesome Place!!! The ambience, seating makes you so comfortable that you just not mind sitting for hours their. :). I would recommend this place to anyone provided you are in a good size group. We did not had food here I went with my brother here and we just had drinks! The couches are the best part here it makes...
the hot and happening branch of delhi.. the rooftop is really very good and the amboence is too good.. the food is also very good and the crowd is also very happening.. will defintiely recommend it to a friend.
I have always been looking for a 'quiet' place where people can just sit and talk and have serious meetings. Everywhere you go, theres loud music, crowd - all you can do is quickly have what you are having and run out. QBA is my pet meeting spot for all official and unofficial meetings.
They have big, comfy couches that...
In large group. Ordered lots of different food and it was pretty good. But the "doof-doof" music was loud and awful. Drinks and food reasonably priced.
Its a nice place to be for a drink and some good food. Though we had hummus and some other snacks so cannot comment much on food but the place is good and has sofas for a comfortable sitting.
We visited qba on an afternoon for lunch and a beer... I was with my wife and sis
The place pleasantly surprised me after getting inside.. Its nice and big and has a lot of seating options like sofas, high chairs, bar stools..
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amazing ambiance, good food, variety of kebabs & cocktail plays good music after evening with lot of positive energy & good crowed
I have been there few times. A nice niche place. With good classy people around. But the food and drinks are not up to the reputation. Very limited choice of food. Service not very friendly. The only thing I like there is the mezze platter. Rest can improve.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


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With six Golden Globe nominations for Mark Wahlberg's "The Fighter," the actor/producer says that this kind of success is "unbelievable."
Wahlberg called into Ryan Seacrest's KIIS FM radio show on Tuesday (Dec. 14) to discuss how thrilling it is this project to be nominated.
"The first thing I did was get down on my hands and my knees and thanked God for allowing me to get Mickey [O'Keefe] and Mickey's story to the screen," he says. "Then I called Mickey and he's just ecstatic, you know. This guy's had a long hard journey and to be immortalized in this way it means the world to them."
Wahlberg has worked tirelessly to get this story to the screen. Training for four years without a studio greenlight on the film, struggling through script re-writes, financing and casting to only have 33 days of actual shooting. The result is incredible and the recognition certainly deserved.
In Wednesday's (Dec. 15) episode of "The Early Show," Wahlberg gets choked up when reminded of all the nominations his film garnered.
"Don't make me cry, please … No, it's insane. No, they'd be happy tears … It's insane that we got the movie made and to have this kind of reaction, it's just mind-blowing, it really is."
Along with his own nomination for best actor, the film is also up for best film, best supporting actor for Christian Bale, best director for David O. Russell, and best supporting actress for both Amy Adams and Melissa Leo.
"The Fighter" isn't Wahlberg's only success this award season. The HBO original series "Boardwalk Empire" earned itself three Golden Globe nominations, for which he is a producer.


text:
Greetings Guest!!Dismiss Notice
In order to combat SPAM on the forums, all users are required to have a minimum of 2 posts before they can submit links in any post or thread.
News Blizzard Streamer Awards - Are the nominations fair?
Discussion in 'WoW Stratics Announcements' started by Syiler, Jan 31, 2014.


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Soft and smooth skin alluring to the touch
trembling in ecstasy under my fingertips
stomach moving up and down
slow rhythmic motions
while my lips caress her womanhood
the sacred rosebud yearning to bloom before me
while soft moans and gasps fills the air
like a soft spring breeze serenading my soul
the dew of her damp skin from the shower she been in
not drying herself off....letting me drink in the droplets
tasting her fresh skin...intoxicating my senses....
as my hunger for her grows deep within my soul...
I want to drink her in...be absorbed within her passion
fulfilling all her secret...lustful desires she keeps inside...
her opens to me...like a rose to the spring sunlight
letting me into the garden of her femininity
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inviting me in to her paradise...where no other man has gone
giving to me all that she is....trusting me with her body...her soul...her heart
as we become as one...hearts entwine...we move in rhythmic unity....
friction between us melting the skin as one...
limbs entwined....pressing bodies closer together....
entranced in this moment together....expressing our hearts affections
in a night of sweet....fiery passion
© Copyright 2017 Michael68. All rights reserved.
Status: Finished
Genre: Romance
Book / Horror
Short Story / Romance
Paste the link to picture in the entry below:
Paste the link to Youtube video in the following entry:
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There was an error uploading your file.


text:
Chicken Chop Suey
|Sliced celery
|2 Cup (32 tbs)
|2 Tablespoon
|Cooked cubed chicken
|2 Cup (32 tbs)
|Canned water chestnuts
|16 Ounce, sliced and undrained
|Canned bean sprouts
|1 Pound (Undrained)
|Canned mushroom stems and pieces
|4 Ounce
|Soy sauce
|1⁄3 Cup (5.33 tbs)
|3 Tablespoon
|Canned chow mein noodles/Hot cooked rice
|3 Ounce
Place celery and butter in a 3 qt.glass casserole dish.
Cover and microwave 3 to 4 minutes or until tender.
Stir once during cooking.
Add chicken and vegetables.
Combine soy sauce and cornstarch.
Stir into vegetable mixture.
Cover and microwave 14 to 16 minutes.
Stir twice during cooking.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1687 Calories from Fat 539
% Daily Value*
Total Fat 62 g96%
Saturated Fat 22.2 g110.9%
Trans Fat 0 g
Cholesterol 305.3 mg101.8%
Sodium 6130.9 mg255.5%
Total Carbohydrates 170 g56.8%
Dietary Fiber 21.3 g85.4%
Sugars 24.8 g
Protein 109 g217.4%
Vitamin A 42% Vitamin C 132%
Calcium 23.8% Iron 97.5%
*Based on a 2000 Calorie diet


text:
It's the second largest economy in the world. Within the decade, it may sustain two-thirds of the planet's workers, according to the Organisation for Economic Co-operation and Development (OECD), and even rival the United States. But it's not China: It's the bazaars, vendors, and informal markets of the world.
Robert Neuwirth's new book, Stealth of Nations, reveals the dealings of back-alley capitalism. And unlike the austerity of the developed world, it's doing pretty well. After several years living in the slums and cities of Brazil, China, and Africa, Neuwirth argues the world's governments should embrace informal (and mostly legal) markets as an alternative form of economic organization. That's not just because they improve the lives of millions of entrepreneurs and their customers, creating upward mobility in otherwise dysfunctional systems, but because we have no choice. Either we cooperate with the off-the-books economic activity exploding in the developing world, or we clash counter-productively with them at every turn.


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Publisher's Description
FileName: list of some good songs
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8/10 (225 votes)
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The St. Regis Deer Valley
2300 Deer Valley Drive East, Park City, UT, 84060, United States
Phone: (435) 940-5700
4.4/5 (10 reviews)
Slopeside sophistication at the base of Park City's Wasatch Mountains
Welcome to our AAA Five Diamond mountainside retreat with access to a world of year-round outdoor sports and the vibrant town of Park City. Enjoy ski-in/ski-out access at world-renowned Deer Valley resort, slopeside views, a private ski beach, Ski Valet, split-level infinity pool, family activities, Remède Park City Spa and more. It's nature refined.
Retreat in grandeur to one of our luxurious guest rooms, suites or private residences. All guest rooms feature spectacular mountain views. Experience the St. Regis Butler service, available in all suite rooms.
Discover an epicurean experience at J&G Grill, enjoy carefully crafted cocktails at the St. Regis Bar or host a private event in the Wine Vault. Retreat to the terrace for great mountain views and patio dining, year-round.
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Reserve your stay online, call 866-716-8116, or contact your preferred travel professional. Please mention promotion code ZS4. Valid for travel through December 1, 2016.
Terms & Conditions
© 2017 Starwood Hotels & Resorts Worldwide, Inc
Guest Reviews
Hear from our guests about their stay from 10 verified guest reviews
83%of our guests
recommend this hotel
We had a wonderful weekend stay with our family at the St. Regis. The rooms were beautiful and the staff was beyond attentive and accomodating. They acknowledged us by name everytime we went in or out of the hotel
When we had special food delivered to the hotel, they took care of heating it up, setting us up at beautiful table in the library and provided waiter service. We have done this before at many hotels, but we have never been treated as nicely as we were here. The concierges went out of their way to do everything they could for us.
My husband brought a bike with him, which the valets/concierges took care of storing for him and they recommended great riding areas for him on the mountain.
My only critique of the hotel is that there was not enough seating by the pool area as there was a big group at the hotel that weekend for a wedding.
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4.4 /5
Rooms & Suites
Hotel Information
- Check-in time: 3 PM
- Check-out time: 12 PM
- Complimentary WiFi
- Valet parking $30/day
- Pets welcome
- SPG Category 7
Hotel Features
- Business center
- Sauna and steam rooms
- Dual-level pool, whirlpool
- Remède Spa
- St. Regis Athletic Club
- View More Hotel Features
Photos & Videos
Explore Park City
Our Location
Located at 2300 Deer Valley Drive, The St. Regis Deer Valley is 25 miles from Salt Lake City International Airport and sits above Park City, Utah.
What's Nearby
- Heber City Municipal Airport
- Salt Lake City International Airport
- Cinemark Holiday Village Movie Theaters
- Eccles Center
- Jupiter Bowl – Bowling Alley
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- Main Street Park City
- The Canyons Resorts
- Utah Olympic Park
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text: The Amazing Swedish Show Real Humans Is Getting An English VersionCharlie Jane Anders4/07/14 6:20pmFiled to: humansreal humansakta manniskortelevisiondoctor whopiers wengerspooksandroidsrobotsartificial intelligence765EditPromoteShare to KinjaToggle Conversation toolsGo to permalink It's a crime that the Swedish android show Real Humans (Äkta människor) hasn't gotten aired in the United States yet. It's widely hailed as one of the best science fiction shows of recent years. But at least, we're getting an English-language version from the writers behind Spooks. Advertisement According to Variety and the Radio Times, the English-language version will be called Humans and will be written by Sam Vincent and Jonathan Brackley (Spooks). It'll air on Channel 4 in the U.K., and on the Xbox in the U.S., with Channel 4 and Xbox producing it along with Kudos, the production company behind Broadchurch. Here's the synopsis of the English version, via Variety: Advertisement Show is set in a parallel present where the latest must-have gadget for any busy family is a "Synth" — a highly-developed robotic servant that's so similar to a real human it's transforming the way people live. When a rushed-off-his-feet suburban father of three buys a refurbished second-hand Synth, he hopes it will relieve some domestic pressure, and paper over the cracks of his marriage. But sharing their life with a machine has far-reaching and chilling consequences — for this Synth, the cuckoo in the nest, is harboring a secret.And there's a quote from Channel 4 Head of Drama Piers Wenger, who used to be a producer of Doctor Who:In 'Humans,' Sam and Jon have not only crafted an ingenious and imaginative thriller, but they're also asking big, thought-provoking questions about how we live. I'm thrilled to be working once again with the team at Kudos and to be partnering with Xbox to bring this extraordinary and epic series to the screen.Do you think this could possibly live up to the Swedish original? Reply76 repliesLeave a reply


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My son is working on an FFA project, and has finished his coop and ready for his hens. He is planning to buy white leghorn pullets. Is this a good breed for him? At what age do they ususally start laying and then at what age to they stop laying. This is be his first time having chickens, so I'm sure we have lots to learn. Thanks for your help!!
FFA Project - White Leghorns?
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My son is working on an FFA project, and has finished his coop and ready for his hens. He is planning to buy white leghorn pullets. Is this a good breed for him? At what age do they ususally start laying and then at what age to they stop laying. This is be his first time having chickens, so I'm sure we have lots to learn. Thanks for your help!!
That depends. What are his goals for this project? He will do much better with his project if he has clear goals from the beginning and it will help him determine if a given breed is appropriate for him or not. Is he looking to sell eggs? Chicks? Showing? Breeding? What's the market for white eggs in your area? Are they going to be confined to the run/coop or is he planning to free range all or part of the day? For pure egg laying ability, it's hard to beat production white leghorns. They are very efficient in their feed use and supposedly handle confinement well. But they can be more flighty than heavier egg laying breeds. Leghorns can also be great foragers, which makes them good for free ranging, but white birds may be more easily picked off by predators.
Thank you for your reply. To answer a few of your questions, his goal is egg production. According to his research, they are very productive layers. And their eggs are high quality. He has built a very nice coop (12 x 16 feet) . It has a nice run as well. He does not plan to allow them to free range. What age do they start and stop laying?
Thanks again!!
They should start at around eighteen to twenty weeks of age. He ought to get about a year of laying from them once they do then they'll need to molt. They'll slow their laying during that period, but most of them should continue to produce eggs just at a slower rate. Once the molt is finished they'll pick up again, but not quite as many as in their pullet year. The ones they do lay will likely be somewhat larger than before.
I have a pen full of Murray McMurray Pearl White Leghorns and like them right well. They're a light bodied active breed so if he wants them to be calm he needs to act calmly and deliberately around them and not do things that may startle them.
Edited by A.T. Hagan - 4/14/11 at 12:09pm
If the chicks are 8-9 weeks, Leghorns are really easy to tell the difference in gender. Look at the combs (on top of the head) and waddles (the kind of droopy things just to the side/below the beaks). A cockerel will be quite red, and significantly bigger and redder than a pullet. A pullet will be very, very pale pink in those areas, and very small combs and waddles.
I raised some white leghorn(ish) chicks last year, and I could easily tell gender well before the 8-9 week mark. If you want, I can try to dig up some pictures of my pullets and my cockerels together so you can see.
I will say that my white leghorn is definitely the flightiest, least friendly of my chickens. She's not as much fun as a pet because she's still very spooked by people. However, she is a fantastic layer. She didn't start laying til she was a good 5 months old though.
- Rest in Peace 1950-2013
My white TSC Leghorn started laying at 17 wks. Never stopped during her molt or during the unusually cold winter. She was the only on laying. Good luck on your sons project.
Retired Nurse
Buff Orpingtons, White Rocks, Brown Leghorns, Lavender Americanas, Easter Eggers and Black Aussies
Retired Nurse
Buff Orpingtons, White Rocks, Brown Leghorns, Lavender Americanas, Easter Eggers and Black Aussies
Thanks for your reply. I just wanted to make sure that the breed he was chosing is a good match for him and his objective. This is probably a silly question, but he is going to look at some this weekend. How do you tell the hens from the roosters at 8 to 9 weeks of age?
By that age the combs on the males will be noticeably larger than those on the females.
You guys are so nice to answer all of these questions. I do have one more though. We are going to look at two sets if chicks tomorrow. One are 10 - 12 week old pullets, and the other are 8 - 10 week olds. I'm sure there is a difference in quality of chicks...just like any other animal. Can you tell me some characteristics we should look for to help assure they will grow to be quality hens?


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Lot 1185: Signed Chelsea 1970 F.A. Cup winners celebration photograph, signed b
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Colorectal neoplasia results from a progressive process of gene mutation and epigenetic alterations that drive the initiation and progression of normal colon to benign adenomas to malignant adenocarcinomas (paralleling histological changes) because these mutations affect signaling pathways that deregulate hallmark behaviors of normal colon stem cells. DNA mismatch repair (MMR), an evolutionary-conserved system that repairs polymerase mistakes after DNA synthesis and corrects insertion/deletion (I/D) loops at microsatellite sequences throughout the genome, is disrupted in the germline of familial colon cancer (Lynch syndrome) as well as inactivated in up to 20% of sporadic colorectal neoplasms due to hypermethylation of one of the components of DNA MMR. The genetic consequences of disrupted DNA MMR is non-repair of the polymerase mistakes and insertion/deletion loops that occur in non-coding as well as coding microsatellite regions after DNA heteroduplexes form first, causing neoplasia to commence that defines the clinical syndromes. We hypothesize that human DNA MMR has specific recognition fidelity in targeting repair of I/D loops, but the fundamentals of how heteroduplex DNA forms are independent of DNA MMR. Our preliminary data using novel constructs in which to measure human DNA MMR mutation indicate that (a) heteroduplex DNA forms prior to mutation and appears independent of the DNA MMR status, and that full mutation is only seen with defective DNA MMR, and (b) the ability of microsatellites to form I/D loops and subsequent mutation is influenced by flanking DNA sequences that surround the microsatellite. Additionally, there is growing evidence that elevated microsatellite instability at selected tetranucleotide repeats (EMAST), seen is 60% of colon cancer specimens, may be associated inflammation-induced reduction of the DNA MMR protein hMSH3, causing this genetic signature. How EMAST fits into the pathogenesis of colon neoplasia is not defined. In this continuation proposal, we will focus on hMSH3 and how deficiency causes EMAST, and determine the biological consequences of EMAST. More specifically, we hypothesize that hMSH3 prevents tetranucleotide frameshifts, and this will be examined in Specific Aim 1. We further aim to understand the role of hMSH3 on influencing potential target genes for mutation (Specific Aim 2). We will also define EMAST by hMSH3 expression, and examine the link of inflammation with hMSH3 and EMAST (Specific Aim 3). The impact of this proposal lies in understanding the fundamentals of how DNA is altered to drive a common cancer, and our ability to potentially intervene ultimately by pharmacologic or direct intervention to prevent occurrence or death from colorectal cancer.
Colorectal cancer is among the most common cancers afflicting Americans. This cancer is derived and driven by conditions, some within DNA, that allow for mutation of key growth regulatory genes that then abrogates their normal regulatory function. This proposal aims to understand how DNA becomes mutated, as well how inflammation may influence this mutation. Ultimately, interfering with this process through pharmacologic or direct intervention should prevent or reduce colorectal cancer deaths.
|Tseng-Rogenski, Stephanie S; Hamaya, Yasushi; Choi, Daniel Y et al. (2015) Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. Gastroenterology 148:579-89
|Carethers, John M (2014) DNA testing and molecular screening for colon cancer. Clin Gastroenterol Hepatol 12:377-81
|Carethers, John M; Murali, Bhavya; Yang, Bing et al. (2014) Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer. PLoS One 9:e100461
|Carethers, John M (2014) Differentiating Lynch-like from Lynch syndrome. Gastroenterology 146:602-4
|Iwaizumi, Moriya; Tseng-Rogenski, Stephanie; Carethers, John M (2013) Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity. Mutat Res 747-748:19-27
|Lee, Sun-Young; Miyai, Katsuya; Han, Hye Seung et al. (2012) Microsatellite instability, EMAST, and morphology associations with T cell infiltration in colorectal neoplasia. Dig Dis Sci 57:72-8
|Chung, Heekyung; Chaudhry, Joy; Lai, Jenny F et al. (2012) Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2). Mutat Res 729:73-80
|Huang, Sherry C; Lee, Jeffrey K; Smith, E Julieta et al. (2011) Evidence for an hMSH3 defect in familial hamartomatous polyps. Cancer 117:492-500
|Tajima, Akihiro; Iwaizumi, Moriya; Tseng-Rogenski, Stephanie et al. (2011) Both hMutSýý and hMutSýý DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity. PLoS One 6:e28117
|Iwaizumi, Moriya; Tseng-Rogenski, Stephanie; Carethers, John M (2011) DNA mismatch repair proficiency executing 5-fluorouracil cytotoxicity in colorectal cancer cells. Cancer Biol Ther 12:756-64
Showing the most recent 10 out of 37 publications


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YET more links coming soon...! including Non-Anglican links
There have been many relevant articles and pieces of information related to the situation here in the diocese of South Carolina in recent days. I have waited until today to post them since I did not want them lost on Veterans/Remembrance Day yesterday. Please note that I post material here which is in circulation but which is, in some cases, factually false, and in others, embarrassingly biased against the diocese. I trust readers to read and sift things carefully and make their own judgments. If you have questions, ask--KSH.
Filed under: * Anglican - Episcopal Episcopal Church (TEC) Presiding Bishop TEC Bishops TEC Conflicts TEC Conflicts: South Carolina TEC Polity & Canons * Culture-Watch Blogging & the Internet * South Carolina * Theology Ethics / Moral Theology Pastoral Theology
Posted November 13, 2012 at 5:30 am [Printer Friendly] [Print w/ comments]
1. wmresearchtrianglenc wrote:
I'd like to be able to forward writings concerning ECUSA's recent actions re the Diocese of S.C. and Bishop Lawrence, several of which appear—on their face—to raise issues of constitutionality under canon law applicable to ECUSA. A. S. Haley's blog is excellent on these issues, as are the analyses of the Anglican Communion Institute, however, many readers will likely find them less than "reader-friendly" because some of the issues will be seen to be arcane and complex to many readers. Thus, in order to easily access writings that are fairly straightforward less complex, regarding this matter (including matters that are directly related), would it be perhaps not too burdensome for you to reorganize your blog format so as to have a section containing issuances from ECUSA and other sources supporting ECUSA's actions in this matter a second section containing articles from media sources re this matter, and a third section containing posts of the Diocese of South Carolina, Alan Haley, the Institute, and others critical of ECUSA's actions in this matter? You've done an outstanding service in posting communications that are currently on the blog, however, I think some reorganization would be of great benefit to those who simply need an easier way to get a grasp on the earlier, current, and possible future developments (in this regard, I believe some media sources regrettably fail to reflect an understanding of the issues involved here).November 13, 5:00 pm | [comment link]
Next entry (above): South Carolina Developments (I)—Two Emails From a TEC Steering Committee Led Group to SC Clergy
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Thailand's main airport is to relocate 12 giant "demon statues" to boost the morale of staff who thought the figures brought bad luck, local media and officials said Tuesday.
The statues at Bangkok's Suvarnabhumi airport will move from the arrivals area to the check-in zone at a cost of around 1.7 million baht (51,000 dollars), said Airports of Thailand (AOT) president Serirat Prasutanond.
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The anti-government PAD seized two of the Thai capital's airports in a crippling eight-day blockade late in 2008, which badly dented the kingdom's tourist-friendly image.
Serirat presided over a religious ceremony at the airport Monday ahead of the relocation of the figures, which are modelled on 12 statues at Bangkok's Grand Palace. He said the move should be finished within 90 days.Reuse content


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December 2016
i loved everything about this trip amazing shrines and the wonderland is amazing
October 2016
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October 2016
This is the best way to see the best of Nikko when you don't have much time and I still wanted to experience Edo Wonderland. Nikko was such an experience that I almost missed the bus to Edo wonderland. Yasui, our tour leader ran back down to the bus driver and held him there till I caught up. Never had a tour leader do that for me. thank you Yasui
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Don't missed the good deal!!! This is the place must go in Japan. My family have a great time during the tour.
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Great entertainment, food was delicious, kids lied it!
June 2016
We loved loved loved Edo Wonderland!
May 2016
Great day trip from Tokyo. The temple visit in Nikko felt a little rushed there was plenty of time to enjoy Edo Wonderland.
December 2015
This tour is good. Edo Wonderland is a much if you want to see Geishas and Maikos in their kimonos and Samurai. It's a traditional Japanese theme park where they have shows to enjoy including comedy show in JAPANESE that we didn't understand any word haha! You also get to do Japanese traditional activities.
November 2015
Good trip, very nice guide and good comfortable bus. It was a long trip, that was the only downside, but we have seen some Amazing views here. Edo wonderland is also fun, especially for my 8 year old son!
June 2015
Edo Wonderland was a great experience. The ninja shows are a must-see.
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The Modeling Core will provide a central resource for all computational modeling across projects. Modeling plays a critical role in this program of research because it links theoretical, behavioral and neuroimaging approaches to understanding the relationship between reading and speech. The "triangle model" of reading is central to this enterprise because it provides a mechanistic explanation of how mappings among spelling, phonology and meaning are learned and used to support reading. Prior work in this framework has provided insights into how phonological and semantic processing contribute to literacy outcomes. All four projects will make contact with the triangle model, integrating insights and new advances from models of phonology (Project II) and sentence processing (Project IV), extending the model to new languages (Project III) and examining how different patterns of constitutive deficits in a variety of language abilities can have different impacts across languages (Project I). This integrative approach will open up new directions in the theoretical and empirical work, and make progress toward a general theory relating the development and use of reading skill to speech and language. Finally, interaction with the Neuroimaging Core (Core B) will produce new ways of interpreting and analyzing fMRI data. The models are pitched at a level that is well-suited to this, because they provide proxies for both behavioral outcomes such as response time and accuracy, as well as internal states that can be directly related to brain activity. Thus, the Modeling Core will coordinate activities across projects and cores that are central to unifying the neurobiological and computational models of reading and its relation to speech
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|Song, Shuang; Su, Mengmeng; Kang, Cuiping et al. (2015) Tracing children's vocabulary development from preschool through the school-age years: an 8-year longitudinal study. Dev Sci 18:119-31
|Dikker, Suzanne; Silbert, Lauren J; Hasson, Uri et al. (2014) On the same wavelength: predictable language enhances speaker-listener brain-to-brain synchrony in posterior superior temporal gyrus. J Neurosci 34:6267-72
|Kornilov, Sergey A; Landi, Nicole; Rakhlin, Natalia et al. (2014) Attentional but not pre-attentive neural measures of auditory discrimination are atypical in children with developmental language disorder. Dev Neuropsychol 39:543-67
|Van Dyke, Julie A; Johns, Clinton L; Kukona, Anuenue (2014) Low working memory capacity is only spuriously related to poor reading comprehension. Cognition 131:373-403
|Pugh, Kenneth R; Frost, Stephen J; Rothman, Douglas L et al. (2014) Glutamate and choline levels predict individual differences in reading ability in emergent readers. J Neurosci 34:4082-9
|Krivokapi?, Jelena (2014) Gestural coordination at prosodic boundaries and its role for prosodic structure and speech planning processes. Philos Trans R Soc Lond B Biol Sci 369:20130397
|Saltzman, Elliot; Holt, Ken (2014) Movement Forms: A Graph-Dynamic Perspective. Ecol Psychol 26:60-68
|Samuel, Arthur G; Lieblich, Jerrold (2014) Visual speech acts differently than lexical context in supporting speech perception. J Exp Psychol Hum Percept Perform 40:1479-90
|Zhao, Jingjing; Wang, Xiaoyi; Frost, Stephen J et al. (2014) Neural division of labor in reading is constrained by culture: a training study of reading Chinese characters. Cortex 53:90-106
|Barquero, Laura A; Davis, Nicole; Cutting, Laurie E (2014) Neuroimaging of reading intervention: a systematic review and activation likelihood estimate meta-analysis. PLoS One 9:e83668
Showing the most recent 10 out of 322 publications


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A trial balloon that went nowhere
The new mayhem came as discord appeared to grow within the National Coalition of Syrian Revolutionary and Opposition Forces, the umbrella anti-Assad group, over a proposal made Jan. 30 by al-Khatib, its leader, to engage in talks with Assad's government aimed at ending the nearly 2-year-old conflict, which has left more than 60,000 people dead.
Although the proposal contained several conditions, including the release of prisoners, it broke a longstanding principle that Assad must leave power before talks can begin.
Many of al-Khatib's colleagues grudgingly went along with the proposal after it had been made, but critical voices have been rising, especially among more militant elements.
In what appeared to be an acknowledgment of the discord, al-Khatib told the BBC's Arabic service from Cairo that his patience with the government was running out. Al-Khatib gave the government until Sunday to release prisoners, especially women, or "the initiative will be broken."
In a video uploaded on YouTube, a cleric from the Nusra Front, an anti-Assad Islamist militant group that the Obama administration has classified as a terrorist organization, said in a prayer speech that brute force was the only solution.
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A highly successful TV personality who's also a highly successful babe.
Could Khaleei's body double be even hotter than Khaleesi herself? Only one way to find out. (Look.)
She has been described as "perpetually topless." Does that interest you?
Lots of tattoos. Lots of skin. Lots of hair colors. Lots to like.


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Sleep Regressions & Physical Milestones
My baby has learned to stand up in his crib. Now how do I get him to lie back down and SLEEP?
My baby has learned to stand up in his crib. Now how do I get him to lie back down and SLEEP?
It's been a week since my daughter nursed! Is this a strike or the end of breastfeeding?
All milk and no solids! What to do with a newly-minted toddler who's stuck with babyish eating habits.
My two-year-old's obsession with the television is growing stronger by the day. How can I set reasonable limits without driving us both to tears?
My mother-in-law watches my children during the day for free, but it's costing me my sanity!
The daycare I chose for my baby turned out to be terrible and borderline neglectful. How can I ever trust my instincts again?
Thanks to everyone who entered the Old Navy giveaway! Unfortunately, we can only have one winner of the five! hundred! dollar! gift card, and according to the algorithm-ninja-robots at random.org, that person is Allison F, who has already been contacted and virtually high-fived us through…
Purees vs. finger foods vs. baby-led weaning and choking and coughing…when did feeding babies get so complicated?
My family is pressuring me to sleep train my three-month-old baby. Are they right that I'll do him a disservice if I wait?
Learn how to make the most of a kid's hand-me-down wardrobe, tell us your ideas and enter to win a $500 gift card to Old Navy. Whee!
Help! My cloth wipes smell like unfinished basement crawl space. What am I doing wrong?
The pros and more pros of siblings sharing a bedroom.
Are we driving ourselves crazy with unrealistic expectations of what staying home is like? OF COURSE WE ARE.
I had a baby and now I can't stop worrying about the end of the world! Is this normal?
My close friend won't stop disparaging my choice to go back to work! Can this friendship be saved?
What to do when your baby has her days and nights completely mixed up.
My baby is sleeping longer at night now. Should I pump or should I sleep?
What's safe? What's not? And how can you possibly know for sure?
How to deal with unsolicited opinions about family size.
After a terrible breastfeeding experience with baby #1, how to overcome fears and anxiety about nursing baby #2.