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Create your own card! Any ideas, just post em!
Originally created by 6SimS-Sven followed by Mr Intelijent then by Edon EG and then by SadisticCynic
To start us off:
7/4 -3 opp damage min 1
bio-The third member of the Circle of Assasins, Kimi is a master of acupuncture and can throw a needle faster than you can Blink, a quick shot to the jugular and you're dead.
Is it just me or did anyone else think Slify commented on this when you first saw the name?
I thought it was -6 opp. life, lol. -6 opp damage is worthless.
@slfy Ziggy is perfectly fine, nice card
I think Ulu Watu needs a better DR. I mean, you have Daddy Jones, Kirk, etc. But it is either massive star-count or bad DR. I think they need a Spiaghi or Sabia. Or why not a copy of Niwa?...
3* Ulu Watu - Murma
Ability: Revenge: - 4 opp damage min. 2
Bonus: Power + 2
Is it balanced at all? Is courage prefered instead of revenge? It must have some kind of condition or else OP. What do oyu think?


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20 mile radius
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At Open Study College we have not only the right course but more importantly the right study method
I am studying the Child Day Care level 3 course and I am really enjoying it. I l...more
Gain a thorough introduction to electrical theory, wiring and installation, technology and much more with this Level 3 Electrical Theory and Maintenance. Course Content Unit 1: Regulation, Safe...more
Duration: Variable
External awarded qualification - non-accredited
Great Teacher, The Course Is Worth The Money!
I always hated school, because my teachers were always horrible to me, because o...more
Site and Electrical Health and Safety Understanding of electrical terms and principles Understanding of practical insstallations, regulations and procedures Understanding and applying of electrical...more
Duration: 34 weeks
Full time
Other regulated/accredited qualification
the oil and gas the life in oil rig is very good and very aenjeypol how to work...more
Head over to Udemy for the final price
What sets an average game apart for a truly amazing visual experience? How can you take your scene from "Oh, thats cool" to " Wow, that's AWESOME!". There are many facets that go into making a game...more
Duration: 2 hours
Multiple levels
Certificate of Attendance
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This short course is ideal for annual refresher training. It covers lighting and ventilation, common accidents and ways to prevent them. The short course content is taken from Level 2 in Health and...more
Duration: Variable
Certificate of Attendance
Really happy I enrolled with Home Study Zone
I have enrolled on A Level Biology and Chemistry with this company and have so f...more
The Electrical Theory and Maintenance Level 3 course is the upkeep and preservation of equipment and systems that supply electricity to a residential, industrial or commercial building. This course...more
Duration: Variable
External awarded qualification - non-accredited
This short course is ideal for annual refresher training. It covers lighting and ventilation, common accidents and ways to prevent them. The short course content is taken from Level 2 in Health and...more
Duration: Variable
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A great insight to changes within Social Housing, a must for all tenants and emp...more
Lesson Plan Preparation for initial inspection and testing Inspection Testing Practice Test questions The online...more
Duration: 15 hours
Course Provider Diploma/Certificate/Award
I don't usually write reviews, however I have been really happy with this course...more
Format: Paper Version If you want to develop your knowledge of Electrical Theory and Maintenance so that you can embark on a rewarding career or maybe you are already working in a related field and...more
Duration: Variable
Certificate of Attendance

subset: commoncrawl


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A lovely sterling silver necklace crafted into the shape of a cats head. An adorable present, provided with a gift message and Dogeared gift pouch. Pendant measures 10mm.
Thank you for visiting Dogeared Sterling Silver Meow Or Never Pendant Necklace, Silver on shoppingfind.co.uk
We bring the products from many websites to one website for you to search, save and compare.


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Two Mount Saint Charles Freshmen Recreate a Brothers' of the Sacred Heart Crucifix
Governor for a Day
Town of North Smithfield Office of the Town Administrator
Mount Saint Charles Senior was Named a Candidate in the US Presidential Scholars Program
Please be advised that the Woonsocket Annual Egg Hunt is once again postponed due to inclement weather (snow) and freezing temperatures.
The event will be rescheduled for Late May/Early June, when the weather is more inclined to cooperate.
Please check with Woonsocket Parks & Recreation on Facebook for updates on this event.
"Unfortunately, outdoor events require the cooperation of the weather and in this case it hasn't been on our side. We deeply apologize for this disappointment but promise to make the May/June date something equally enjoyable and exciting!"
Thank You to everyone who has helped spread the word about this fantastic tradition, while it will be delayed this time; we look forward to a wonderful day in the very near future!


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Publisher's Description+
From NDSU Alumni Association: Bison Tracker is about YOU! The games you attend, the tailgates you visit. It's all about your Bison memories. A next-generation social media application, BisonTracker connects with your friends. Check into Games!Track your Travel!Plan your next Adventure!
What's new in this version:
Switch to basketball, add back Strobe
read more +


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Or simply click here to ask us a question
Affordable, quality frying oil, specifically designed to withstand the rigours of high temperature deep frying. Ideal for use with range fryers.
Our exclusive range offers great value and provides good aeration and creaming properties for quality results every time.
Provide plasticity and workability for great tasting shortcrust and laminated pastries. Ideal for French and Scotch production methods.
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The summer brings a host of challenges to the bakery industry. Demand for baked goods can drop as the temperature rises, and seasonal bestsellers such as mince pies are still months away. Ne......Read more
Over the past few years the demand for Gluten Free products has increased significantly. This is not only driven by the 1% of ......Read more
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Mellow Mushroom
1098 Bermuda Run Rd (at Fair Rd), Statesboro, Georgia, USA, 30458
Serves meat, vegan options available. Part of chain of pizzeria restaurants most often found in college towns in southern USA states. Serves pizzas, calzones, salads, and hoagies (with grilled tempeh, avocado, mushroom, and tofu options). Very few vegan choices but they do have vegan cheese. Theme is laid-back hippie. Open Mon-Sun 11:00am-10:00pm.
Category: Vegan-friendly, Lacto, Ovo, American, Fast food, Take-out, Non-veg
Reviews (1)First Review by hdeweyh
Mellow Mushroom - great vegan pizza! - Edit
I visited a mellow mushroom outside atlanta while on a long road trip and I was not disappointed! I am a new yorker and mellow mushrooms vegan pie was right up there with my fave NYC vegan slices. It is not new york style but thick delcious crust piled high with topping including daiya vegan cheese (they have a sticker on their fron door!) One 10" pie can easily feed you for 2+ meals making the slightly high price tag a little sweeter:)
I got the mega veggie and asked for it vegan and the waiter knew just what I meant. Cute psychedlic atmosphere too, a real winner. They even have gluten free crust. The only thing that would make this place even better would be if they had a vegan pie listed on the menu instead of substitutions.
Pros: delicious pizza, atmosphere
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Cleveholm Manor
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
Travel Blogs from Redstone
Day 43 - Independence Pass & Aspen
... a really nice little place called Aspen Over Easy. They did breakfast along with normal lunch. The food was so good and we are already planning on revisiting here when we hopefully go back for the X-Games in January.
After a little walk around Aspen we headed back home which took just under 2 hours.
We were pretty full so the evening consisted of relaxing, cuddles and ...
At last some rest/ Un peu de repos enfin
... enjoys this break is Mr Pickles who is just now sleeping before we are going hicking in the mountains. The weather here is absolutly amazing reaching above 80 f so we have to wait early afternoon before heading up ! As well I am out of shape after a month just using my right foot to accelerate or braking and my ten fingers to get on the internet.
Internet, yes I am in the country that send a man walking on ...
Home Sweet Colorado
Bats out of hell. That's what you call people who drive like we do----heading east through the damn Nevada deserts as fast as our little Prius can go.
By 11 pm we arrive at a campground in Green River Utah. The tent is up in five minutes and we are in it asleep two minutes later. At 6 am the ...
Another 4 Wheeling Adventure
... thing that I had ever seen. After snapping some pictures and taking it all in we headed up the trail a little more to the ghost town of Crystal. There is actually one person who lives up there and he runs a small gift shop. While there I ran into one of those professional jeep tours. I decided to jump in front of him on the trail back so that someone would find the bodies if we rolled off a cliff or something. OK ...
Cheyenne to Glenwood Springs
I started out on my journey from my home in Cheyenne, WY at 4:30AM to jump ahead of the relentless Denver commuter traffic. As I neared Denver, I merged onto I-70 and started my way through the Rocky Mountains. Shortly into my climb on I-70 I passed through the Eisenhower Tunnel, which at 11,158 feet is the highest point and longest tunnel on the U.S. Interstate Highway system. Upon descending from ...


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Tango Time!
By Myriam Mees
14 Easy Tangos for Violin. Composed by Myriam Mees. Arranged by Gunter Van Rompaey. De Haske Play-Along Book. Play Along. Softcover with CD. De Haske Publications #1053795400. Published by De Haske Publications (HL.44005501).
Item Number: HL.44005501
ISBN 9043122025. 9x12 inches.
This book/CD pack features 11 tanguitos (little tangos) and three milongas written for violinists who have already mastered the first position and are able to perform the tango with verve and inspiration.


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About (In The Form of a Fake FAQ)
What camera do you use?
Here's a timeline of the cameras I've used since I started this blog:
May '10: Canon 7D with a Sigma 18-50mm F2.8 EX DC macro lens
Aug '07 - May '10: Canon 20D
June '06 - Aug '07: Canon Rebel XT
Before June '06: Canon SD 450
I "post process" all my photos in Photoshop to make them suck less. Of course, you need a camera to take semi-decent photos first, but without Photoshop, I am nothing.
Where'd the name of your blog come from?
I named this blog after one of my favorite books, The Man Who Ate Everything by Jeffrey Steingarten. The first time I met Jeffrey Steingarten, he joked about suing me for partially using the name of his book. Hahaha!
...He scares me a bit.
Do you know there's another food blog called "The Girl Who Ate Everything"?
YUUUUP oh well.
Do you actually eat everything?
...Alllmmmmost everything. The only food I avoid is spicy food because it tends to make my lungs gurgle in a way that makes it difficult to breath. As much as I love spicy food, I must say I love breathing more than I love spicy food. :(
I also avoid eating bugs and anything that's alive or seemingly alive. I think that's reasonable.
Are you good at cooking?
Not really. Up until October 2015, to which point I had mostly lived in NYC, I rarely cooked because I'm lazy and eating out is one of my favorite pasttimes. But in October 2015, I moved to Bergen, Norway to live with my Norwegian husband, and since then I've had to cook almost every day. Eating out in Bergen is either too expensive or not really worth it. And that's fine with me. I've gotten used to staying at home and cooking.
Do you make any money off this blog?
Once upon a time I had ads on this site, but now this blog is ad- and revenue-free! WEEEEEE (rolls around in piles of nonexistent money).
If for some reason you want to help me out monetarily, here are some ways:
- Buy stuff through my Amazon ID
- Buy my shirts and bags at maigocute.com
- Get webhosting with Dreamhost.com and enter firstname.lastname@example.com as the referral
Thank you so much for your help!
Do you...make any money?
Currently, not really. I'm unemployed and settling into living in Norway. Before this, I had worked at Serious Eats in New York City for about seven years as a editor/writer/photographer/doodler.
How'd you get that awesome job at Serious Eats?
Connections and luck. ...And maybe some skills, but more of the former. I feel bad when people ask me for advice on how to work in the online food journalism industry—I don't know what to say. Time travel? If you go my route, you'd have to have been born in 1985 so that your college graduation nicely lines up with the infancy of the food blog world, which was so small in the mid-2000s that it wasn't difficult to be noticed as long as you were fairly competant and your photos weren't terrible. You'd also be living in a big city like NYC where there are more opportunities to find jobs such as "working at a food website." Through the referral of another food blogger (hi, Adam!), I started as an intern at Serious Eats in the beginning of 2007 while getting my undergraduate degree in Food Studies. When I graduated later that year, Serious Eats was only one year old and had yet to find its legs. They hired me straight on. I didn't have any competition. I'm not saying they hired me just because I was a human who was there, but I was definitely in the right place at the right time.
Basic info:
Name: Robyn Lee
Age: 30
Location: Bergen, Norway
Flickr: flickr.com/photos/roboppy
Instagram: instagram.com/roboppy
Facebook: facebook.com/thegirlwhoateeverything
Old-ass homepage: diskobox.net
Email: firstname.lastname@example.com
How may I contact you?
Email is the best way to contact me, but honestly, I'm pretty bad at replying in a timely manner. Feel free to poke me more than once to make sure I'm not dead! I love hearing from readers!
If you're from a PR firm and want to contact me about something you're promoting, you probably shouldn't. I don't write solicited reviews. I don't care about new cookbooks or cooking gadgets. I'm 99% sure I can't go to whatever event your promoting and even if I could, I wouldn't be interested.
If you want to contact me about licensing my photos, please be clear about how you want to use the photo and what your photo rates are.


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Derek Fisher is shooting poorly for Thunder
The first game of the ESPN doubleheader Wednesday night before the Lakers-Clippers intra-city showdown pitted projected NBA Finals qualifiers Oklahoma City and Miami.
Derek Fisher, traded by the Lakers to Houston and winding up with the Thunder, got to play in the marquee matchup. He did not have much impact in the game won by Miami, 98-93.
Fisher shot 1 for 4 from the field (0 for 2 on 3-pointers) with two assists and no turnovers in 17 minutes. In eight games with Oklahoma City, Fisher has shot 9 for 37 (24.3 percent) from the field despite delivering some productive scoring in the Thunder's victory over the Lakers on Thursday. Fisher has shot 3 for 15 (20 percent) on 3-pointers for Oklahoma City.
[rssfeedme cat="lakers" feedpath="/category/Lakers/feed/" max="5"]
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Market Research Analyst Salary
For Market Research Analysts, yearly average wages total $51K annually. Total incomes of Market Research Analysts incorporate potential for, in a few cases, more than $9K from bonuses and close to $10K from profit sharing; these performance components cause packages to range between $35K and $75K. Compensation for this group is mainly affected by experience level, but the specific employer and geography are influential factors as well. Most enjoy medical while a strong majority get dental coverage. Vision coverage is also available to more than half. Women make up a slight majority of Market Research Analysts (52 percent) survey respondents. For the most part, Market Research Analysts enjoy their work and report high levels of job satisfaction. This report is based on answers to PayScale's salary questionnaire.
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Job Description for Market Research Analyst
A marketing research analyst reviews a large amount of data, analyzing it to answer three major questions: What product does the market want? Who are the consumers that would purchase such a product? How much would consumers pay for the product? Their main goal is to help the company's profits grow over time by using available data. They analyze interviews, collect prospective consumer data via surveys, and include relevant statistics in a final report for their clients or management team. Most analysts work during regular business hours in an office setting, although overtime may be required on time-sensitive projects.Read More...
Market research analysts typically have a bachelor's degree in marketing; however, some analysts may have a bachelor's degree in math, computer science, business, or another field. Research analysts can also receive certification from the Market Research Association in lieu of a bachelor's degree, depending on their education and work experience; this certification must be renewed every two years.
Market Research Analyst Tasks
- Assist in the development of marketing plans.
- Track and analyze marketing and sales trends, forecasts and prepare reports in order to measure the effectiveness of programs.
- Conduct research market conditions in specific areas, and analyze customer preferences to determine potential sales of a product or service.
- Gather data on competitors and past sales to analyze prices and methods of marketing and distribution.
Common Career Paths for Market Research Analyst
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Market Research Analysts might see a strong upturn in salary after transitioning into upper-level roles such as Market Research Manager, a seemingly popular career choice. People currently working in the latter position report a noticeably higher median income of $75K per year. Market Research Analysts typically move into roles as Senior Market Research Analysts or Marketing Managers, and those positions pay $17K more and $10K more, respectively.
Market Research Analyst Job Listings
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Popular Skills for Market Research Analyst
Market Research Analysts report using a deep pool of skills on the job. Most notably, facility with Presentations, Client Interaction, and SQL are correlated to pay that is significantly above average, leading to increases of 30 percent, 8 percent, and 6 percent, respectively. Skills that pay less than market rate include Powerpoint, Technical Writing, and Microsoft Excel. For most people, competency in Data Analysis indicates knowledge of Market Analysis and Microsoft Excel.
Pay by Experience Level for Market Research Analyst
Median of all compensation (including tips, bonus, and overtime) by years of experience.
Workers in their first five years can expect to earn $50K, but people who have been around for five to 10 years earn a noticeably bigger sum of $66K. Market Research Analysts bring in $70K after working for 10 to 20 years. People who have worked for 20 years or more actually report earning less than people who are in the middle of their careers; the veterans take home a mere $60K by contrast.
Pay Difference by Location
Home to some of the best pay for Market Research Analysts, Washington offers exceptional salaries, 10 percent above the national average. Market Research Analysts can also look forward to large paychecks in cities like New York (+10 percent), Portland (+9 percent), Atlanta (+8 percent), and San Francisco (+6 percent). In Detroit, salaries are 11 percent below the national average and represent the lowest-paying market. Denver and Milwaukee are a couple other places where companies are known to pay below the median — salaries are 8 percent lower and 5 percent lower, respectively.
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Key Stats for Market Research Analyst
52 %
48 %
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Fuel efficiency
- In 2015, railroads in the U.S. moved a ton of freight an average of 479 miles per gallon of fuel, up from 235 miles in 1980, doubling their efficiency. On average, railroads are four times more fuel efficient than trucks. (AAR, 2016)
- Because greenhouse gas emissions are directly related to fuel consumption, railroads have a lower carbon footprint. Moving freight by rail instead of truck reduces greenhouse emissions by an average of 75 percent. (AAR, 2016)


text: Food Heat Thyself! Eating a Day's Worth of Self-Heating RationsMark Wilson8/28/09 2:20pmFiled to: Taste TestHeater mealsMresSelf-heating foodTop1011EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Carry-out is lazy. But men are ultra lazy. Ordering pizza or simply using a microwave is often beyond us. We require nothing short of Futurama's Bachelor Chow. And when I discovered Heater Meals, I thought we may have found it. Advertisement You see, the military has deployed ultra-bachelor food preparation technology for decades under the moniker of MREs. Once accessible to only the most manly of men in the most dangerous circumstances the world has to offer, these self-heating dinners have migrated over the counter as well, this time marketed to truckers and seniors in RVs.Heater Meals are almost certainly the most popular consumer-grade "MRE" on the market. Advertisement So I embarked on a day of eating just self-heated foods from the company. These meals in a bag come with the same "Flameless Ration Heater" used in MREs. The element is basically a permeable paper pouch loaded with "supercorroding" magnesium-iron alloy. When water touches the pouch, stand back, because it gets hot. For the smarter among you, that equation looks like Mg+2H2 O→Mg(OH)2 +H2 +heat (and steam). So a basic Heater Meal comes with a pouch of food, a pouch for heating the food (loaded with one of those heating elements) and a tiny bag of water to start the reaction. You put the food bag into the heating pouch, mix in the water, then seal the whole rig back into the box. Wait 10-12 minutes and you've got yourself a hot meal. (If all that sounded complicated, that's only because it sort of is.)Breakfast Ahh, bacon and eggs. Or should I say Hydrating Water for Fried Egg Product mixed with Freeze Dried "hearty" Scrambled Eggs and bacon. After mixing the egg powder with water (an additional step stacked onto the process described above), then cooking, the substance slid from its pouch as a convenient, rectangular mass. The temperature was hot (140 degrees by thermometer!) and the texture was believably eggy (other than the crisped edges and a yolk that congealed into an inedible solid). But the flavor was something closer to a hard-boiled egg than a scrambled one. Objectively, this taste should have been palatable, but something in me was repulsed, urging me not to take more than a few bites. And the included spice pack did little to remedy the situation. As for the bacon, it never really heated to a temperature that would make its chewy texture and liberal use of liquid smoke forgivable. However, my cup of Metropolis coffee (not bundled) was delicious. Lunch Lunch was Southwest Style Chicken with Rice and Beans, a soulless but edible jambalaya boasting an extended shelf life of five years before perishing. A very viscous mix, the sauce coated the fork and wouldn't come off, while the chunks of chicken contained almost no moisture split between my teeth like tenderized erasers. My palate was left with a sticky, metallic resonance. But really, all this was OK, nothing quite offensive but nothing quite wonderful either. What I really wanted was salt (to counter the senior-friendly sodium levels) and a bit of hot sauce. So I enlisted the help of some Sriracha and all was well with the world as I finished a meal that would still be good in June of 2014. Its 480 calories coupled with 28 grams of protein left my hunger satiated, my morale for self-heating meals boosted. Dinner By now I'm an expert. I don't consult the instructions, ripping open packs and boxes and fluids and mixing with little abandon. Green Pepper Steak with Rice will be dinner. And while it squeezes onto my plate in a manner eerliy similar to lunch, the aroma of green pepper greets my nose in a familiar way...like food should. The flavor is balanced between meatiness and the acidic pepper. And while the steak has that eraser-texture of lunch's chicken along with a floral aftertaste I could do without, the crunch of a sporadic water chestnuts brighten the solemnity of monotony. The dish could still use salt, but at 350 calories a plate, the stuff is practically health food. And under that lens, it's tough to bitch too much. The BillEvery meal ends with bad news, so here are the real catches of eating self-heating food. The instructions fail to mention that once the food bag has steamed to a proper temperature, you need to squeeze the piping hot mixture onto a plate. This burns when attempted bare-handed (which I did three times because I'm as stubborn as I am stupid), especially as that bag is covered with heating fluids that sting any cuts on your hands. And just what do you do with a sizzling pad of magnesium-iron alloy when it's no longer cooking your food? You can't just turn off a chemical reaction, so you're left with what's essentially a Maxi Pad of heat and a small amount of noxious gray water. Advertisement Sponsored So it ends up that Heater Meals are tougher to prepare than microwaved ones, meaning that they can't possibly be the future for lazy, hairy, helpless males. But I will say, you could do worse than stick a few boxes of their meat/rice mixtures into your bomb shelter. Because while a Heater Meal can't beat takeout, a hot meal will taste damn good amidst a nuclear fallout, trust me. [Heater Meals]Taste Test is our weeklong tribute to the leaps that occur when technology meets cuisine, spanning everything from the historic breakthroughs that made food tastier and safer to the Earl-Grey-friendly replicators we impatiently await in the future.Reply101 repliesLeave a reply


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Best Banana Cake
|1⁄2 Cup (8 tbs)
|1 1⁄2 Cup (24 tbs)
|2 Large
|Sifted flour
|2 Cup (32 tbs)
|Baking powder
|2 Teaspoon
|3⁄4 Teaspoon
|1⁄2 Teaspoon
|1⁄4 Cup (4 tbs) (or sour milk)
|1 Teaspoon
|1 Cup (16 tbs), mashed
Cream together butter and sugar until light and fluffy; beat eggs lightly and add to creamed mixture.
Sift together dry ingredients and add alternately with sour milk, beginning and ending with flour.
Add vanilla, mixing thoroughly.
Fold in bananas, stirring well.
Pour into two greased and floured 9-inch layer pans or 1 (9-inch) tube pan and bake in preheated 350 degree oven for 50 minutes.
Fill between layers and top with sliced bananas and sweetened whipped cream.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 408 Calories from Fat 115
% Daily Value*
Total Fat 13 g20.2%
Saturated Fat 7.7 g38.5%
Trans Fat 0 g
Cholesterol 83.1 mg27.7%
Sodium 368 mg15.3%
Total Carbohydrates 69 g22.9%
Dietary Fiber 1.6 g6.3%
Sugars 41.2 g
Protein 6 g11%
Vitamin A 8.6% Vitamin C 4.1%
Calcium 10.9% Iron 10.6%
*Based on a 2000 Calorie diet


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Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response
- Magda Nakou†1,
- Georgios Katsikas†1,
- Prodromos Sidiropoulos1,
- George Bertsias1,
- Eva Papadimitraki1,
- Amalia Raptopoulou1,
- Helen Koutala2,
- Helen A Papadaki3,
- Herakles Kritikos1 and
- Dimitrios T Boumpas1Email author
DOI: 10.1186/ar2798
© Nakou et al.; licensee BioMed Central Ltd. 2009
Received: 3 February 2009
Accepted: 28 August 2009
Published: 28 August 2009
Bone marrow (BM) is an immunologically privileged site where activated autoantibody-producing B cells may survive for prolonged periods. We investigated the effect of rituximab (anti-CD20 mAb) in peripheral blood (PB) and BM B-cell and T-cell populations in active rheumatoid arthritis (RA) patients.
Active RA patients received rituximab (1,000 mg) on days 1 and 15. PB (n = 11) and BM (n = 8) aspirates were collected at baseline and at 3 months. We assessed B-cell and T-cell populations using triple-color flow cytometry.
Rituximab therapy decreased PB (from a mean 2% to 0.9%, P = 0.022) but not BM (from 4.6% to 3.8%, P = 0.273) CD19+ B cells, associated with a significant reduction in the activated CD19+HLA-DR+ subset both in PB (from 55% to 19%, P = 0.007) and in BM (from 68% to 19%, P = 0.007). Response to rituximab was preceded by a significant decrease in PB and BM CD19+CD27+ memory B cells (P = 0.022). These effects were specific to rituximab since anti-TNF therapy did not reduce total or activated B cells. Rituximab therapy did not alter the number of activated CD4+HLA-DR+ and CD4+CD25+ T cells.
Rituximab therapy preferentially depletes activated CD19+HLA-DR+ B cells in the PB and BM of active RA patients. Clinical response to rituximab is associated with depletion of CD19+CD27+ memory B cells in PB and BM of RA patients.
Rheumatoid arthritis (RA) is a complex inflammatory autoimmune disease characterized by disturbances in T-cell and B-cell functions. Clinical and animal studies highlight the multiple roles of B cells in the development and severity of RA, including production of autoantibodies, inflammatory cytokines such as TNF and IL-6, and aberrant antigen presentation [1]. Recent data in animal models suggest that, among these effects, the antigen-presenting capacity of B cells may be of particular importance in RA pathogenesis [2].
Rituximab is a chimeric mAb against CD20 that induces a profound depletion of B cells in the peripheral blood of RA patients [3]; however, little is known about the qualitative and quantitative aspects of deletion achieved in tissues including the bone marrow (BM) and lymph nodes. Initial studies in humans with RA suggest that B cells are also depleted in the BM as well as in the synovium [4]; nevertheless, the depletion is rather incomplete [5].
The BM is important for the biology of B cells as it represents a site of B-cell differentiation and maturation. The BM is an immunologically privileged site, where stroma promote B-cell survival and thus may protect B cells from depleting therapies [6]. We have previously described quantitative and qualitative changes in the BM of RA patients, which could affect a variety of BM resident cells including the B cells [7, 8]. Furthermore, based on gene expression studies of lupus patients, we have reported that the BM may be more informative than peripheral blood (PB) in differentiating active from inactive lupus patients and in differentiating patients from control individuals [9]. In the present article we explored the effect of rituximab treatment on B-cell subpopulations in the periphery and in the BM in a cohort of RA patients with resistant disease.
Materials and methods
Patients and treatment
Thirty-one RA patients with active disease (disease activity score of 28 joint counts (DAS28) >5.1) despite treatment with disease-modifying anti-rheumatic drugs including at least one anti-TNF agent, were selected to receive rituximab. Patients were followed in the Department of Rheumatology, Clinical Immunology, and Allergy, University Hospital of Heraklion (Greece).
PB and BM specimens were obtained from 11 consenting patients without predefined selection criteria. Samples were obtained at baseline and after 12 weeks of treatment. Rituximab was administered as a 1,000 mg intravenous infusion on days 1 and 15 [3]. Seven RA patients starting anti-TNF agents were used as controls for the immunological study. Patients had not received steroids for at least 24 hours before PB and BM sampling. Written informed consent was obtained from all patients and healthy controls, and the study was approved by the Ethics Committee of the University Hospital of Heraklion.
Clinical assessment
Clinical parameters (28 swollen and tender joint counts), functional status (Health Assessment Questionnaire), and laboratory parameters were regularly assessed every 2 months. The DAS28 was applied to assess clinical efficacy [10]. The European League Against Rheumatism response criteria based on DAS28 were used to assess the response to therapy [11].
Isolation of mononuclear cells and flow cytometry
PB mononuclear cells and BM mononuclear cells were isolated by Ficoll-Histopaque (Sigma-Aldrich, St Louis, MO, USA) density-gradient centrifugation of heparinized samples. Cells (5 × 105) were stained with the appropriate amounts of fluorochrome-conjugated monoclonal antibodies for 30 minutes on ice. Combinations of anti-CD19, anti-HLA-DR, anti-CD27, anti-CD38 and anti-CD45 staining were used for analysis of B cells. For analysis of T cells, anti-CD3, anti-CD4, anti-HLA-DR, and anti-CD69 staining was performed. IgG isotype controls were used in all experiments to determine the positively-stained cell population. Antibodies to CD19, CD69, CD27, CD45, and CD38 were purchased from Immunotech (Marseille, France), and anti-HLA-DR, anti-CD4, anti-CD3 antibodies were purchased from eBioscience (San Diego, CA, USA).
At least 200,000 events were collected in the lymphocyte gate for analysis in an Epics Elite flow cytometer (Coulter, Miami, FL, USA). Lymphocyte subsets were defined as follows: naïve B cells, CD19+CD27-; memory B cells, CD19+CD27+; activated B cells, CD19+HLA-DR+; activated T cells, CD4+HLA-DR+, CD4+CD25+, CD4+CD69+. Owing to the low proportion of CD19+ cells, all analyses were performed in constant numbers of CD19+-gated cells.
Statistical analysis
Clinical characteristics of the patients and response to rituximab therapy
Demographic and clinical characteristics of rheumatoid arthritis patients treated with rituximab
Age (years)
62 (1.8)
Female (%)
Disease duration (years)
15 (2.8)
Previous therapies
Number of disease-modifying anti-rheumatic drugs used
2.6 (1 to 5)
Number of biologic agents used
1.6 (0 to 3)
Baseline disease characteristics
Rheumatoid factor-positive (%)
Disease activity score of 28 joint counts
6.3 (0.2)
Swollen joints (28 joints)
9.3 (1.1)
Tender joints (28 joints)
12.8 (1.3)
Patient's pain assessment
69.7 (2.9)
Patient's global assessment
67.3 (3.3)
Physician's global assessment
54.8 (3.4)
Health Assessment Questionnaire
0.9 (0.09)
Erythrocyte sedimentation rate (mm/hour)
51 (6.1)
Hemoglobin (g/dl)
12.9 (0.4)
Concomitant disease-modifying anti-rheumatic drugs
Patients (%)
Dose (mg/week)
16.3 (7.5 to 25)
Patients (%)
Dose (mg/day)
17 (10 to 20)
Patients (%)
Dose (mg/day)
5.5 (5 to 10)
Rituximab monotherapy
Rituximab therapy depletes B cells in peripheral blood, but not bone marrow, of RA patients
Immunological studies were performed in 11 consenting patients whose demographic and clinical characteristics were comparable with the remaining patients who received rituximab. We first assessed the effects of rituximab on B cells in RA patients 3 months after therapy.
Rituximab preferentially depletes activated CD19+HLA-DR+cells in peripheral blood and bone marrow of RA patients
A key feature in RA pathogenesis is the aberrant antigen-presenting capacity of B cells, contributing to chronic T-cell activation and perpetuation of inflammation in the joint. We therefore assessed the effect of rituximab therapy on B-cell HLA-DR expression, a marker of activation and antigen-presenting function. The proportion of HLA-DR+ cells within the CD19+ cell fraction in PB significantly decreased from 57 ± 12% to 18 ± 9% (P = 0.05) (Figure 1c, d). In contrast to the total numbers of CD19+ cells, a comparable reduction in the percentage of HLA-DR+ cells within the CD19+ cell fraction was observed in the BM of RA patients who received rituximab (from 69 ± 11% to 20 ± 10%, P = 0.007) (Figure 1c). Rituximab therefore effectively and preferentially depletes activated HLA-DR+ B cells both in the PB and the BM of RA patients.
Favorable response to rituximab therapy preceded by a decrease in CD19+CD27+memory B cells in peripheral blood and bone marrow of RA patients
Depletion of total and activated B cells is a specific effect of rituximab therapy
Finally, we examined the effect of rituximab on activated CD4+ T cells by measuring the expression of the activation markers CD25 and HLA-DR by flow cytometry. We found no significant change in the percentage of CD4+CD25+ T cells (from 11 ± 2% to 7 ± 1%, P = 0.563) and CD4+HLA-DR+ T cells (from 7 ± 2% to 5 ± 1%, P = 0.667) 12 weeks after rituximab treatment (Figure 3b). Changes in CD4+ T-cell markers did not correlate with the degree of B-cell depletion or response to therapy.
In the present study, we investigated the effects of rituximab on PB and BM lymphocyte subsets in patients with active RA. Rituximab effectively reduced CD19+ B cells in the PB of patients; a less pronounced effect was observed in the BM. Importantly, rituximab therapy preferentially depleted activated CD19+HLA-DR+ B cells in both compartments. The relative low clinical response rate in our population probably reflects the fact that these patients represent the most severe and refractory subset among our cohort, with several of them having failed multiple biologic therapies.
Expression and signaling through MHC class II molecules is important for effective antigen presentation and induction of co-stimulatory molecules on B cells [12]. Animal models of inflammatory arthritis support an important role of B cells in disease pathogenesis through a variety of mechanisms, including aberrant antigen presentation and activation of autoreactive T cells in the joint [13]. HLA-DR+ B cells have been suggested to be important for B-cell-mediated T-cell activation; depletion of HLA-DR+ cells could therefore represent an additional mechanism for the beneficial effects of rituximab in RA.
The BM is a primary lymphoid organ where B-cell differentiation and maturation occurs; BM stroma promote B-cell survival and protect B cells from depleting therapies [14, 15]. In accordance with this observation, we found that rituximab therapy efficiently reduced PB CD19+ B cells but had only a weak effect on BM CD19+ B cells. The change in BM B cells did not correlate with clinical response to therapy or other disease parameters in the small patient number tested.
Previous studies have suggested the depleting effect of rituximab may be more pronounced in the PB than in inflamed tissues or lymphoid organs. Kavanaugh and colleagues found that - unlike PB B cells, which were profoundly (>95%) depleted after rituximab therapy - synovial B cells decreased but were not eliminated [16]. Similarly, in 24 RA patients who received rituximab, PB B cells were depleted at 4 weeks whereas synovial B cells were only moderately reduced and persisted in five patients [5]. Local tissue expression of B-cell survival factors (for example, B-cell activation factor belonging to the TNF family, stromal cell-derived factor-1, macrophage migration inhibitory factor) [17–19] might explain the relative resistance of B cells against the depleting effect of rituximab. Moreover, data both from animal models [20] and from humans [4, 21] have shown that the effect of B-cell depleting therapies in lymphoid organs is variable. To this end, Teng and colleagues found that only 32% of RA patients had complete depletion of CD19+ cells within the BM as compared with 100% in the PB [4]. Leandro and colleagues reported a variable degree of B-cell depletion within the BM [21].
In our cohort, four out of 11 patients had incomplete B-cell depletion in PB - a relatively high proportion compared with that observed by other studies. Nevertheless, resistance to rituximab has been described in autoimmune-prone animals. In MRL/lpr mice and in NOD mice it has therefore been shown that B cells are relatively refractory to depletion compared with nonautoimmune-prone strains [20, 22]. In lupus-prone mice, high doses and extended duration of rituximab has been shown to overcome resistance to depletion; while in NOD mice, deficient FcγRI binding to IgG2a CD20 mAbs and reduced splenic monocyte numbers have been implicated in impaired B-cell depletion. The importance of FcγR in antibody-dependent cell-mediated cytotoxicity as a mechanism for B-cell depletion has been also shown in lupus patients treated with rituximab [23]. Whether these mechanisms are involved in reduced B-cell depletion in our patients needs to be addressed.
The significance of incomplete B-cell depletion at the sites of inflammation has not been fully determined, but investigators have suggested that disease progression - despite PB B-cell depletion - is probably due to survival of memory B cells, which expand in secondary lymphoid tissues and produce autoantibodies. In line with this hypothesis, Leandro and colleagues reported that patients who relapsed early after repopulation of PB B cells had a trend (P = 0.170) for a higher percentage of CD19+CD27+ memory B cells compared with those patients that relapse later [24]. Roll and colleagues also performed immunophenotyping in the PB of RA patients who received rituximab, and reported a significantly higher proportion of IgD+CD27+ memory B cells during B-cell recovery in nonresponders [25]. Moreover, Thurlings and colleagues found that the reduction of synovial tissue plasma cells, which are normally derived by memory B cells, between weeks 4 and 16 after treatment predicted clinical improvement at 24 weeks [5]. Accordingly, Möller and colleagues reported that low numbers of peripheral blood memory B cells (IgD-CD27+) correlated with good clinical responses in RA patients treated with rituximab [26].
Our data further support these findings since we observed a significant decrease in CD19+CD27+ memory B cells not only in the PB but also in the BM of RA patients who subsequently responded to rituximab. In contrast, memory B cells in nonresponders remained stable or even increased in both compartments. Together these data suggest that analysis of memory B-cell subsets may provide important information on the efficacy and response to rituximab therapy, consistent with the notion that targeting cells with the memory phenotype is a key determinant for its efficacy. Whether persistence of PB and/or BM memory B cells is related to the lack of response after rituximab retreatment observed in RA patients who did not exhibit clinical improvement after the first treatment course [27] remains to be determined.
Previous studies have indicated that rituximab may affect T-cell responses in systemic lupus erythematosus patients through downregulation of activation and co-stimulatory molecules (for example, CD69, CD154). This effect was attributed to decreased antigen-presenting function of B cells after rituximab treatment. We assessed the population of activated CD4+CD25+ and CD4+HLA-DR+ T cells, but we found no consistent changes according to response to therapy. Similarly, Thurlings and colleagues found no effect of rituximab therapy on PB CD4+ or CD8+ T cells of RA patients [5], whereas Leandro and colleagues reported a decrease only in a small subpopulation of CD3+CD20+ cells while the total CD4+ subset and the activated CD4+ subset remained unaffected [24]. Nevertheless, an effect on T-cell activation/function cannot be excluded. Therefore, although B-cell depletion in an animal study had no effect on T-cell subsets and activation markers, it impaired adaptive and autoreactive CD4+ T-cell activation [28].
Of note in small uncontrolled trials of systemic lupus erythematosus patients, it has been reported that rituximab reduces activated CD4+ cells in parallel with B cells. To this end, Sfikakis and colleagues reported that lupus patients responding to rituximab downregulated CD40 ligand, CD69 and HLA-DR expression on CD4+ cells [29], while Tokunaga and colleagues reported downregulation of CD40 ligand, inducible costimulatory molecule (ICOS) and CD69 on CD4+-positive cells in patients (n = 3) with active systemic lupus erythematosus [30, 31]. Whether the effect of rituximab on activated T cells is disease specific remains to be seen.
Response rates according the European League Against Rheumatism criteria (45% good and moderate responders) were moderate in our cohort. Nevertheless, this was a group of RA patients who were highly active refractory to previous treatment. All but one patient had failed in treatment with anti-TNFα agents (up to three agents). Although we found no correlation between clinical response and the degree of peripheral B-cell reduction, incomplete B-cell depletion (four out of 11 patients) could potentially be one of the reasons for lower clinical responses.
Rituximab effectively reduced PB CD19+ B cells in RA patients whereas its effect was less pronounced in the BM. Activated CD19+HLA-DR+ cells were significantly reduced in both compartments. Importantly, clinical response was associated with the persistence of memory B cells in both compartments.
bone marrow
disease activity score of 28 joint counts
- mAb:
monoclonal antibody
peripheral blood
rheumatoid arthritis
tumor necrosis factor.
The present project has been funded in part by the Hellenic Society of Rheumatology. MN and GB are graduate students of the Graduate Program of the Molecular Basis of Human Diseases.
Authors' Affiliations
- Martinez-Gamboa L, Brezinschek HP, Burmester GR, Dorner T: Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy. Autoimmun Rev. 2006, 5: 437-442. 10.1016/j.autrev.2006.02.004.View ArticlePubMedGoogle Scholar
- O'Neill SK, Glant TT, Finnegan A: The role of B cells in animal models of rheumatoid arthritis. Front Biosci. 2007, 12: 1722-1736. 10.2741/2184.View ArticlePubMedGoogle Scholar
- Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004, 350: 2572-2581. 10.1056/NEJMoa032534.View ArticlePubMedGoogle Scholar
- Teng YK, Levarht EW, Hashemi M, Bajema IM, Toes RE, Huizinga TW, van Laar JM: Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment. Arthritis Rheum. 2007, 56: 3909-3918. 10.1002/art.22967.View ArticlePubMedGoogle Scholar
- Thurlings RM, Vos K, Wijbrandts CA, Zwinderman AH, Gerlag DM, Tak PP: Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response. Ann Rheum Dis. 2008, 67: 917-925. 10.1136/ard.2007.080960.PubMed CentralView ArticlePubMedGoogle Scholar
- Minges Wols HA, Underhill GH, Kansas GS, Witte PL: The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity. J Immunol. 2002, 169: 4213-4221.View ArticlePubMedGoogle Scholar
- Kastrinaki MC, Papadaki HA: Mesenchymal stromal cells in rheumatoid arthritis: biological properties and clinical applications. Curr Stem Cell Res Ther. 2009, 4: 61-69. 10.2174/157488809787169084.View ArticlePubMedGoogle Scholar
- Papadaki HA, Kritikos HD, Valatas V, Boumpas DT, Eliopoulos GD: Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. Blood. 2002, 100: 474-482. 10.1182/blood-2002-01-0136.View ArticlePubMedGoogle Scholar
- Nakou M, Knowlton N, Frank MB, Bertsias G, Osban J, Sandel CE, Papadaki H, Raptopoulou A, Sidiropoulos P, Kritikos I, Tassiulas I, Centola M, Boumpas DT: Gene expression in systemic lupus erythematosus: bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures. Arthritis Rheum. 2008, 58: 3541-3549. 10.1002/art.23961.PubMed CentralView ArticlePubMedGoogle Scholar
- Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, Putte van de LB, van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995, 38: 44-48. 10.1002/art.1780380107.View ArticlePubMedGoogle Scholar
- van Gestel AM, Haagsma CJ, van Riel PL: Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis Rheum. 1998, 41: 1845-1850. 10.1002/1529-0131(199810)41:10<1845::AID-ART17>3.0.CO;2-K.View ArticlePubMedGoogle Scholar
- Nabavi N, Freeman GJ, Gault A, Godfrey D, Nadler LM, Glimcher LH: Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature. 1992, 360: 266-268. 10.1038/360266a0.View ArticlePubMedGoogle Scholar
- O'Neill SK, Shlomchik MJ, Glant TT, Cao Y, Doodes PD, Finnegan A: Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol. 2005, 174: 3781-3788.View ArticlePubMedGoogle Scholar
- Grammer AC, Lipsky PE: CD154 - CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus. Arthritis Rheum. 2002, 46: 1417-1429. 10.1002/art.10287.View ArticlePubMedGoogle Scholar
- Moser K, Tokoyoda K, Radbruch A, MacLennan I, Manz RA: Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol. 2006, 18: 265-270. 10.1016/j.coi.2006.03.004.View ArticlePubMedGoogle Scholar
- Kavanaugh A, Rosengren S, Lee SJ, Hammaker D, Firestein GS, Kalunian K, Wei N, Boyle DL: Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results. Ann Rheum Dis. 2008, 67: 402-408. 10.1136/ard.2007.074229.PubMed CentralView ArticlePubMedGoogle Scholar
- Gore Y, Starlets D, Maharshak N, Becker-Herman S, Kaneyuki U, Leng L, Bucala R, Shachar I: Macrophage migration inhibitory factor induces B cell survival by activation of a CD74 - CD44 receptor complex. J Biol Chem. 2008, 283: 2784-2792. 10.1074/jbc.M703265200.View ArticlePubMedGoogle Scholar
- Seki T, Selby J, Haupl T, Winchester R: Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. 1998, 41: 1356-1364. 10.1002/1529-0131(199808)41:8<1356::AID-ART4>3.0.CO;2-X.View ArticlePubMedGoogle Scholar
- Tan SM, Xu D, Roschke V, Perry JW, Arkfeld DG, Ehresmann GR, Migone TS, Hilbert DM, Stohl W: Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis. Arthritis Rheum. 2003, 48: 982-992. 10.1002/art.10860.View ArticlePubMedGoogle Scholar
- Ahuja A, Shupe J, Dunn R, Kashgarian M, Kehry MR, Shlomchik MJ: Depletion of B cells in murine lupus: efficacy and resistance. J Immunol. 2007, 179: 3351-3361.View ArticlePubMedGoogle Scholar
- Leandro MJ, Cooper N, Cambridge G, Ehrenstein MR, Edwards JC: Bone marrow B-lineage cells in patients with rheumatoid arthritis following rituximab therapy. Rheumatology (Oxford). 2007, 46: 29-36. 10.1093/rheumatology/kel148.View ArticleGoogle Scholar
- Xiu Y, Wong CP, Bouaziz JD, Hamaguchi Y, Wang Y, Pop SM, Tisch RM, Tedder TF: B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol. 2008, 180: 2863-2875.View ArticlePubMedGoogle Scholar
- Anolik JH, Campbell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ: The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus. Arthritis Rheum. 2003, 48: 455-459. 10.1002/art.10764.View ArticlePubMedGoogle Scholar
- Leandro MJ, Cambridge G, Ehrenstein MR, Edwards JC: Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum. 2006, 54: 613-620. 10.1002/art.21617.View ArticlePubMedGoogle Scholar
- Roll P, Dorner T, Tony HP: Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and B cell subset regeneration after repeated treatment. Arthritis Rheum. 2008, 58: 1566-1575. 10.1002/art.23473.View ArticlePubMedGoogle Scholar
- Möller B, Aeberli D, Eggli S, Fuhrer M, Vajtai I, Vogelin E, Ziswiler HR, Dahinden CA, Villiger PM: Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis. Arthritis Res Ther. 2009, 11: R62-10.1186/ar2686.PubMed CentralView ArticlePubMedGoogle Scholar
- Thurlings RM, Vos K, Gerlag DM, Tak PP: Disease activity-guided rituximab therapy in rheumatoid arthritis: the effects of re-treatment in initial nonresponders versus initial responders. Arthritis Rheum. 2008, 58: 3657-3664. 10.1002/art.24035.View ArticlePubMedGoogle Scholar
- Bouaziz JD, Yanaba K, Venturi GM, Wang Y, Tisch RM, Poe JC, Tedder TF: Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc Natl Acad Sci USA. 2007, 104: 20878-20883. 10.1073/pnas.0709205105.PubMed CentralView ArticlePubMedGoogle Scholar
- Sfikakis PP, Boletis JN, Lionaki S, Vigklis V, Fragiadaki KG, Iniotaki A, Moutsopoulos HM: Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial. Arthritis Rheum. 2005, 52: 501-513. 10.1002/art.20858.View ArticlePubMedGoogle Scholar
- Tokunaga M, Fujii K, Saito K, Nakayamada S, Tsujimura S, Nawata M, Tanaka Y: Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab. Rheumatology (Oxford). 2005, 44: 176-182. 10.1093/rheumatology/keh443.View ArticleGoogle Scholar
- Tokunaga M, Saito K, Kawabata D, Imura Y, Fujii T, Nakayamada S, Tsujimura S, Nawata M, Iwata S, Azuma T, Mimori T, Tanaka Y: Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system. Ann Rheum Dis. 2007, 66: 470-475. 10.1136/ard.2006.057885.PubMed CentralView ArticlePubMedGoogle Scholar
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Rumour mills in full swing about expected Cabinet reshuffle
Manama: Hours after the announcement of the parliamentary elections' first round results, rumours about the expected Cabinet reshuffle swept the kingdom.
Al Wefaq Society, Bahrain's largest opposition society, in its constitutional political debut after it boycotted the elections in 2002, won 16 seats.
It hopes to boost the figure in Saturday's run-off polls by winning three more seats through opposition candidates running under the National Democratic Action banner.
But Bahrainis have already started talking about how ministers from Al Wefaq will be appointed to the new government that will be formed early next month.
Al Wefaq leader Shaikh Ali Salman said the government had not made any suggestion about nominating any of its members, but added that he would welcome such a move.
"Giving ministerial portfolios to the opposition will certainly create new bridges of cooperation and understanding between the legislative and executive branches and will have positive effects on Bahrain's political reality," Salman said in a press statement.
The appointment of an opposition figure would not be new in Bahrain. In November 2002 following Bahrain's landmark legislative elections, King Hamad Bin Eisa Al Khalifa appointed Majid Al Alawi, who was formerly living in exile in London, to the post of Minister of Labour and Social Affairs.
According to the rumours, the former health minister Dr Jawad Al Arayyedh would become the deputy prime minister, and Mansoor Bin Rajab would be the next minister of municipalities and agriculture.
But sources close to the incumbent minister Ali Saleh Al Saleh promptly denied the rumour, saying that the veteran politician was not aware of such a plan.
The current justice undersecretary Shaikh Khalid Bin Ali Al Khalifa would be promoted to the post of minister while Dr Ali Al Aradi would be the next health minister.


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Out and About: Andy Warhol in Tel Aviv; Israeli Bands in Berlin
The Museum of the Jewish Diaspora in Tel Aviv is showing Andy Warhol's Jewish portraits.
Folk legend Pete Seeger supports a financial, but not an artistic boycott of Israel.
"Hitler and the Germans," an exhibit at Berlin's German Historical Museum, is a huge hit.
Also a huge hit in Germany: Israeli bands.
Leonard Bernstein's late opera "A Quiet Place" will play in New York for the first time.
Tony Kushner talks "Angels in America."
What is an authentic Jewish relationship to the arts?
Linguist Sol Steinmetz has died.
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Pennsauken, NJ (December 24, 2014)–On Saturday night, January 24 at the GPG Event Center (Formerly the Woodbine Inn) in Pennsauken, New Jersey, the inaugural boxing will take place with local favorite and Middleweight contender, Harry Joe Yorgey taking part in a bout for the WBU World Middleweight title.
The show is promoted by Witherspoon's Silver Spoon Promotions.
Yorgey of Bridgeport, PA has a record of 27-2-2 with 12 knockouts and is coming off a draw … Read Article


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by Duncan Larkin, Published Dec. 6, 2010
Kenyans dominated the marathon, while a Baylor University senior won the half.
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The first record of banding birds in North America dates back to 1803 when John James Audubon tied silver cords to the legs of phoebes. This allowed him to identify two of the nestlings when they returned the following year. It wasn't until 1902 when the first scientific system of banding began in North America. In the early 1900's concerns over the declining numbers of waterfowl, passenger pigeons and over harvesting of egrets for their plumes resulted in an international agreement to manage migratory birds. Over the past century banding data has been a critical tool used to manage waterfowl. Banding birds requires capturing them and when it comes to waterfowl the most effective method is the use of rocket netting.
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a religious system based on getting knowledge of yourself and spiritual fulfilment through courses of study and training See related entries: Types of belief Culture Scientology was established in 1954 by the US writer of science fiction L Ron Hubbard. It is based on his book Dianetics (1950) and officially became the Church of Scientology in 1965. It believes in a 'life energy' and encourages its members to improve themselves in a spiritual way by a greater understanding of themselves. The organization has been criticized for the methods it uses to attract and keep members. They include several well-known actors, including Tom Cruise and John Travolta. Word Originfrom Latin scientianounjump to other results
BrE BrE//ˌsaɪənˈtɒlədʒi//; NAmE NAmE//ˌsaɪənˈtɑːlədʒi//[uncountable] Types of belief
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What is it like be to a courier for Hermes:
"Working for hermes is great, driving around and meeting different people, not one day is the same."
"It's good to be a Hermes Courier as I do flexible hours around other commitments, I service alongside family members and the pay is good for the hours I actually service."
"I enjoy being a courier as I get to meet lots of different people and being a courier for Hermes allows me to work around my other commitments as necessary."


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Protests over Spain unemployment figures
25 April 2013 Last updated at 22:35 BST
Spain's unemployment rate soared to a new record of 27.2% of the workforce in the first quarter of 2013, according to official figures.
The total number of unemployed people in Spain has now passed the six million figure, although the rate of the increase has slowed.
The figures prompted demonstrations.
Gavin Hewitt reports.


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No wonder sales are up. Hope he makes a profit. I'll buy one for the cabin. One of these days one of the kids will pick it up and say, "WTF?"
One cannot reason someone out of something they were not reasoned into. - Jonathan Swift
Correction noted regards,
1. Possesses common sense (that's rare in DC) and values reflective of many Americans
2. Believes Americans don't want elitists
3. Says education isn't all it's cracked up to be
4. Takes issue with those who don't believe in free enterprise principles (capitalism)
5. Believes Americans want positive change, but admits it may not be her that must bring it
Sounds good to me regards,
BTW, she wasn't running for 'the most powerful job in the world'.
Sadly both parties but it seems more so the left when trying to demonize someone they always say how stupid they are. "Potatoe" for example. A person makes a statement or 2 that is wrong and they are toast. I dont understand how Biden gets a pass. I would have thought BHO Mr 57 states, would have him muzzled by now. BTW the best and brightest (both sides) have gotten this country to the point it is currently and hows that workin out. I also dont think she is electable at least right now.
"Communism only works in Heaven, where they don't need it, and in Hell, where they already have it" Ronald Reagan
God Bless PFC Jamie Harkness. The US Army's newest PFC, but still our neighbor's little girl!


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Collins-Daigle wedding is Feb. 9
Wed, 2013-01-23 15:40
Melvin and Melissa Hebert of Morgan City wish to announce the engagement and approaching marriage of their daughter, Katey Lynn Daigle, to John Joseph Collins, son of Percy Collins Jr. and Veronica Collins of Houma. The wedding will take place at 3 p.m. Feb. 9 at Rip Van Winkle Gardens in New Iberia. Submitted Photo/Margaret LeBrun
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| Follow .
Focus: Misc Wrestling, Since: 04-27-08
Founder: Peaceful Havoc - Stories: 79 - Followers: 0 - Staff: 2 - id: 57931
A great collection of wrestling fan fiction from some of the best authors on the site. These stories never fail to brighten our day! Also, every story that giftiebee and JCEdgeRKO have written.


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Embedd ipernity images in WordPress in various ways.
V is
medium or
small images only. It can't be used in custom CSS yet bu it's likely that the next release will fix it so that all additional CSS classes can be used.
Requires: 3.0 or higher
Compatible up to: 3.4.2
Last Updated: 5 years ago
Active Installs: 10+
Got something to say? Need help?


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Carpenter / Joiner
Added 25/01/2017
i I need my sons bedroom door planed as soon as possible
Carpenter / Joiner
Added 18/12/2016
Need 2 kitchen units removing and disposing of the materials.
Carpenter / Joiner
Added 04/10/2016
I had some carpet fitted and need the bottom of two doors to be trimmed.
Carpenter / Joiner
Added 20/08/2016
looking to have a new Canopy fitted above my front door, the current one the wood has rotten....
Carpenter / Joiner
Added 04/06/2016
Replace/install 1 x solid external door Also required: install door frame Additional information:...
Carpenter / Joiner
Added 20/05/2016
We require a 2.5 meter breakfast bar fitting in the kitchen which will be a standard 60mm chipboard,...
John did a great job - I thoroughly recommend him.
Excellent job and reasonable price, turned up on time and my neighbours now want to use the same company. Definitely use again
Chris was able to make exactly what we were hoping for. In a loft conversion, with awkward spaces, he was able to create a beautiful wardrobe and cupboard space, that suits the room and looks beautiful.
Very very pleased with this firm, Karen & Steve the bosses are nice people to deal with and agreed a good price .Dave the fitter was a very nice bloke and a good tradesman + him and kevin were very helpful and willing to help . A fantastic job all round. THANKS AGAIN
Very good you would never know they were there just got on with there worrk never stopped very clean and polite would use them again
Igor was polite, professional and had experience that meant he was able to give some good advice and tips with the work. He was very reliable and efficient. Would recommend and use again.
Reliable, friendly, easy to contact and got on the with the job quickly and professionally. I would def use them again.
Managing your job is easier with the Rated People Homes App, download it today.


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Jazmine's P.O.V
"No!!!!I'm not going!I don't want to go!"guess what?My so called best friend,Leayla(Lay-la),is forcing me to go to a justin bieber concert.ok,i do like him,as in i am his fan and stuff but i'm too lazy to go!When i'm lazy,I am lazy!
"Come on please?For me?I'll buy you tons of candy and chocolate."Leayla begged me.Oooo candy Ooooo chocolate!hmm maybe i could...
"I'll go if you will buy ice cream too!"i screamed,excitedly.
"Okay.I will,now get your butt up and shower!It's like 4pm and you have not even bathe!"she scolded me >:(
"Sheesh.At least im agreeing to go."(the next set will be clothes that she wore for the concert)
*After sometime*
"K!I'm done!Let's go!Leayla!"
"Seriously Jaz?Seriously?You gonna wear that?Are you for serious?"Leayla said making a 'seriously?' face.
"What's wrong with it?It's a concert anyway."I said,not agreeing with her.
"You didn't even wear a justin bieber shirt."she said with a 'unbelieveable' expression.
"Oh!Come!I bought things for you!I'm gonna makeover you!"
"Okay..Leayla,it's just a concert."she was weird,well,i'm more weird than her but I love her.k bye.
She just pulled my hand and pushed me in the huge walk in closet and starts forcing me to change.After changing,she cakes me with make up.
I heard a car horn outside.Hmm..who would it be?
"Oh!the limo's here!Quick Jaz,let's go!"
"What?!Limo?!Lea(Le-ah a nickname)!"she ran away to get her bag before i could even catch her..
© Copyright 2017 Zoohighrawr. All rights reserved.
Status: Finished
Genre: Fan Fiction
Um...You need to space out the words after punctuation OK?
Book / Romance
Book / Fan Fiction
Paste the link to picture in the entry below:
Paste the link to Youtube video in the following entry:
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Don't hand out a standard lanyard at your marketing event or tradeshow, instead, hand out these great polyester custom lanyards with a metal crimp and bottle opener that everyone will want.
3.25 inch long MAG-LITE ® promotional flashlight. Small yet powerful!
ePromos has many promotional products created by companies in the USA. These product can be customized for your business and are made here in the USA


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- Country
- United States
- Ratings
- Share
The Essential Conditioner is a daily reconstructing mask which targets the specific needs of aging hair. This rich concentrated conditioner repairs and rebuilds weakened, moisture deprived locks.
Each active ingredient is as decidedly unique as they are effective in restoring the hair's condition, moisture, strength and SHINE. Instantly repairing the damage caused by everyday styling and chemical services with a nutrient-rich, hydrating blend of Baobab, Macadamia nut oil, known as the "vanishing oil", Rosehip, and two moisture-drenching rain forest butters, Cupuacu and Phulwara. The deep penetrating and protective complex of Marula, Camelina, Meadowfoam and Abyssinian oils help prevent further breakage while restoring the elasticity and SHINE to dull lifeless hair.
|6.5oz / 195ml
7 ml packet
|7 ml packet Sample


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This grant application is a companion to the application submitted by Dr. Mark Kupersmith for the Neuro-Ophthalmology Research Disease Investigator Consortium (NORDIC). This application describes a Data Coordination and Biostatistics Center (DCBC), a Visual Field Reading Center (VFRC) and a Photography Reading Center (PRC) that together will provide the crucial infrastructure for the conduct of the NORDIC projects described in Dr. Kupersmith's application. The functions of the VFRC and PRC are detailed in the attached individual applications. The DCBC will provide all project coordination, data management and biostatistical collaboration for all NORDIC projects. DCBC personnel will play a central role in the formulation of each project including: refining study hypotheses and analytic plans;concretizing the project in a study protocol, manual of procedures, and model informed consent;and developing an integrated data management plan. Additional project coordination tasks include: obtaining and maintaining appropriate approvals from applicable regulatory agencies (e.g., FDA, Health Canada) as necessary;identification and collection of relevant regulatory documents;training of site personnel;study drug procurement, packaging and distribution;tracking and reporting study events, contracting with and managing other vendors needed in NORDIC projects (e.g., central laboratory). Additional data management activities include: developing and providing access to electronic Case Report Forms (eCRFs);training sites in the use of electronic web-based data capture system from eResearch Technology;tracking and cleaning project databases;and generating reports of data collection timeliness and accuracy. Additional biostatistical activities include conducting final analyses and contributing to study publications;liaising with the DSMC for report generation;and conducting and reporting secondary and exploratory analyses. The clinical and biostatistical personnel of the DCBC have successfully collaborated for over >15 years on dozens of multicenter clinical research projects. This experience will support the successful conduct of NORDIC projects. The creation of the NORDIC Network with the DCBC, VFRC, and PRC is significant from a public health standpoint in that it provides the essential infrastructure to perform wide reaching prospecitve research that will properly evaluate potential treatments in neuro-ophthalmalogic disorders that collectively affect millions of people.
|Friedman, Deborah I; McDermott, Michael P; Kieburtz, Karl et al. (2014) The idiopathic intracranial hypertension treatment trial: design considerations and methods. J Neuroophthalmol 34:107-17
|Wall, Michael; Kupersmith, Mark J; Kieburtz, Karl D et al. (2014) The idiopathic intracranial hypertension treatment trial: clinical profile at baseline. JAMA Neurol 71:693-701
|NORDIC Idiopathic Intracranial Hypertension Study Group Writing Committee; Wall, Michael; McDermott, Michael P et al. (2014) Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA 311:1641-51
|Perry, Julian D; Feldon, Steven E (2009) Rationale for radiotherapy in thyroid eye disease. Am J Ophthalmol 148:818-9


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Jonathan Adler: Obamacare ruling limits federal power
From Jonathan Adler at the Bench Memos blog on National Review Online:
It's unfortunate that Chief Justice John Roberts joined the liberal justices to uphold the individual mandate as a tax. Yet as I understand the ruling, the opinion does very little to enlarge the federal government's power and, in key respects, reinforced federalism limitations on federal power. According to SCOTUSBlog, while Chief Justice Roberts concluded the mandate is a tax, he also rejected the Commerce Clause arguments in favor of the mandate. This is significant, because it will limit the ability of Congress to adopt additional mandates in the future. No one will be able to claim such requirements are not a tax, and this will make such requirements more difficult to enact.
Equally important, the majority narrowed the Medicaid provisions substantially in a way that reinforces the principle that Congress' power to impose conditions on the receipt of federal spending. Specifically, the Court held that Congress may attach conditions on the receipt of new money — in this case the Medicaid expansion, but that Congress may not condition the receipt of funds for separate, pre-existing programs on compliance with the conditions for the new program. In other words, if states refuse to go along with the Medicaid expansion, they don't lose existing Medicaid funds. If my understanding is accurate, this opinion would mark the firmest limit on use of the spending power in decades, and could constrain lots of future mischief.
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Low-Cost PDF Alternatives
IT managers who don't want to fork over $449 for Adobe's Acrobat 8 Professional should consider lower-priced alternatives.Users have relied on Adobe Systems Acrobat Professional for years, not only for its PDF creation capabilities but also for its workflow and collaboration functionality. For users who only need to create and convert PDF documents, though, there is little reason to shell out the $449 for Adobes Acrobat 8 Professional. Click here to read eWEEK Labs review of Acrobat 8 Professional.
As IT managers begin to think about and plan their Microsoft Office 2007 deployments, they should also remember that Microsoft offers a free downloadable plug-in that introduces PDF creation capabilities to the office productivity suite.
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The Demon and the Damozel
Dynamics of Desire in the Works of Christina Rossetti and Dante Gabriel Rossetti
"The Demon and the Damozel provides a model of what a psychoanalytic criticism of poetry can be. The readings Waldman offers are astute, nuanced, and beautifully grounded in the details of the poems, which shimmer with meaning in her deft handling of them."
"(Waldman's) use of psychoanalytic concepts in interpreting works by Christina and Dante Gabriel Rossetti is exemplary and her study presents new and often fascinating interpretations of their works."
"(T)hanks to Waldman's nimble psychoanalytic commentary, the chronologically re-ordered House of Life emerges as a brilliant quest for transcendence.…The sequence…occasions some of Waldman's most engagingly ambitious claims about Rossetti's anticipation of modern psychoanalytic theory."
Developing a perspective on Victorian culture as the breeding ground for early theories of the unconscious
and the divided psyche, The Demon and the Damozel: Dynamics of Desire in the Works of Christina Rossetti and Dante Gabriel Rossetti offers a new reading of these eminent Victorian siblings' literature and visual arts.
Suzanne M. Waldman views well-known poems and artworks such as Christina Rossetti's Goblin Market and Dante Gabriel Rossetti's The Blessed Damozel and Venus Verticordia in new ways that expose their authors' savvy anticipation of concepts that would come to be known as narcissism, fetishism, and the symbolic and imaginary orders, among many others. Waldman makes a strong case for the particular psychoanalytic importance of the Rossettis by looking at how the two Rossetti siblings' own psyches were divided by conflicts between the period's religious scruples and its taste for gothic sensationalism.
The Demon and the Damozel is a close and contextualized reading of their writings and artwork that displays, for the first time, continuity between the medieval cosmologies these Pre-Raphaelites drew upon and the psychoanalytic theories they looked ahead to—and locates the intricate patterns of proto-psychoanalytic understanding in the rich tapestry of Pre-Raphaelite aestheticism.
Suzanne Waldman teaches in the English department at Carleton University, Ottawa.
Order a print copyHardcover · $31.96 · Add to Cart
Retail price:
$39.95 · Save 20% ($31.96)
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Availability and price vary according to vendor.
RequestsDesk copy Examination copy Review copy
- Permission to reprint
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Related SubjectsVictorian Studies · Monograph · Art · Poetry · Christina Rossetti · Victorian Era · 19th century
Retail price: $39.95, S.
Release date: Sep. 2008
208 pages · 6 × 9 in.
Rights: World
Release date: Sep. 2008
≅208 pages


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Trend Lab® Gray Fleece Changing Pad Cover
Price $22.99
This Trend Lab® Changing Pad Cover is both stylish and comfortable! The soft, gray coral fleece design is fully elasticized, offering a sleek, tailored fit and allowing you to effectively comfort your baby while protecting your changing pad.
- Fits standard sized changing pads
- Machine washable
- Imported
Shipping & Returns
Shipping your purchase is easy on belk.com. Depending on the destination of your package, you can expect it to arrive within 4-7 business days. Shipping Information
Returns are easy on belk.com. Easy returns


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This mannequin is made of made of pin-able foam rubber so its bendable arms can be adjusted to any flex position.
The head is detachable and can turn 360 degrees and the arms are detachable and rotatable on shoulder joints
Comes with a metal stand that goes in the foot.
Fits most children's sizes 18month-24month
2' 10" Tall
21" Chest
19" Waist
20" Hip
9.5" Shoulder
10" Neck
Shipping: $35.00


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This valance bracket set contains 2 valance arms, 2 back plates (wall boxes), 2 system connectors and fixings.
Can be used for wall fixing or ceiling fixing.
It is designed for use with the Swish L400 valance which simply clips onto the front of the arm. The system connector slides onto a haunch at the rear of the bracket and the track is then attached and locked into position between 50mm to 60mm from the wall. For greater flexibility or when not using a valance, please consider the Swish metal extension brackets.
Can also be used with Swish Deluxe.
If the item is required urgently please give us a call and we will see what we can do to help!
Web Exclusive PriceTelephone orders will incur a £3.50 admin fee on orders below £20.
Service rating : Satisfied customer.Product : Glad I could still purchase required replacement parts, thanks.
Full range of metal curtain poles perfect for eyelet, tab top or pleated curtains.
Bay window solutions for square and angled bays.
A great range of wooden curtain poles in a variety of sizes and finial styles.
From L shape windows to poles for doors, we have a solution for you!


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The Most Helpful M&T Bank Reviews
The most helpful favorable review
Customer Service
Just a quick note about your employee Joan ... She was just fantastic in helping w/our account access and is very knowledgeable.. friendly .. and helpful.. One of your better employees..
The most helpful critical review
Skank Of America Sold My Mortgage To M T Bank. Terrible Customer Service!
First off i have a $20 fee added to my account which my bank says is from a bad check fee, to which i always had auto draft with bofa. No explanation for this, was actually told to call bank of america to sort it out. Originally setup auto draft with mtbank, then they took two payments for one month, over drafting my account of which other bills began even more over drafting and the $25 fee for each transaction. Customers service said they would refund the payment but in form of paper check and i would have to send in my bank account statement for them to review whether i get reimbursement for the overdraft fees. They can take money out instantly but can't put it right back. Some bank! I hate that i had no choice to inheret such a handicapped mortgage provider. Ever notice that the name sounds like "empty bank"?
Latest M&T Bank Reviews
RReviewed By Rsmcguirk1234567 Feb 8, 2017
Awful customer service could cost you
My car loan:. Never sent first bill, setting me up for late charges, the first rep on the phone said it's there policy not to send first month bill to customers bc the loan hasn't been generated yet. Lol. Impossible. And illegal if it were true. The rep was awful, would not confirm information, playing games, and had absolutely no idea what she was talking about. So I hung up, called back, got a different rep and we were able to settle my first payment easily. So, this bank is not dependable, if you carry a loan with them, don't wait to be billed, figure out your payment due date, get a physical mailing address and take it upon yourself to send the bill each month. Remember, as a loan holder, you have everything to lose and them everything to gain on not sending bills to you and late fees. And if you get a rep o. The phone that is difficult, nasty or moronic, hang up and call back. Keep doing this until you get someone on the phone that actually cares to help you. Organizations with employees like this are shady. After you send in a bill, snail mail if that's what you use, call them two days later to make sure it actually posts. Yes, they are this bad. Finally, my account number is issued by them but their automated phone service won't recognized it. If these people make it so hard to pay them, soon they will catch you on crazy penalties and late fees. And would I ever set up an automated payment with M&T, like give them access to my bank account? LOLOLOL. Think of the damage they could do. If you can avoid this bank, you really should.Thank you for your feedback Is this review helpful?
SReviewed By Strongwolf Jan 30, 2017
Very satisfied
I'm very happy with this bank . It's convenient because there are branches near by.Thank you for your feedback Is this review helpful?
TReviewed By Tyboogie28 Jan 6, 2017
The worst bank experience ever!!!
December 23, 2016 I went to cash two checks one was my paycheck and the other was a child support check I was told I couldn't cash them unless I had the amount on the checks in my account to cover them mind you I've cashed checks at other m@t banks before with no problem I ask to speak with the manager she tells me the same thing i never had a bank where I had an account tell me they couldn't cash my check I am switching banks immediately I suggest you do the same.Thank you for your feedback Is this review helpful?
AReviewed By Aconpag1x Dec 30, 2016
Wish I had come here before I started my mortgage process
I have been working with a rep from the mortgage division in round lake NY and it's exactly what everyone is saying. They never return emails, calls or respond to anything. I have been given a closing g date twice now and all of a sudden they need more documents. Now my interest rate is about to expire and the Feds have raised interest rates so I'm guessing it's being done on purpose so they can get me for a higher rate.Thank you for your feedback Is this review helpful?
SReviewed By Soupy12828 Dec 14, 2016
Called main branch yesterday,the person I talked to was very rude and no help.Looking for a new bank today......Thank you for your feedback Is this review helpful?
TReviewed By thefarrelledge Nov 30, 2016
Great service!!
Every time we have questions about our business account, the staff at the Brighton branch are extremely helpful and courteous. We've been with the bank for over 5 years now, and never have had a problem with anythibng.Thank you for your feedback Is this review helpful?
RKReviewed By Robert K. Nov 16, 2016
I made a deposit IN PERSON @ M&T Bank, Hagerstown, Md. and it has not showed up on my statement!?
I have only had this account for two months, and i never could tell how much money was in my account, their "CREATIVE BOOKKEEPING" is designed to get the most Overdraft Charges possible! I made a deposit to insure that i would have extra money in my account to avoid any more over charges, IT DIDN'T WORK! In the beginning, i made two deposits on THE SAME DAY, and the second deposit did not show on my statement for (4) four days later? When i questioned them about it, they said the second deposit (made on a Monday) was after 2:PM and that's why it didn't show, WELL WHAT HAPPENED TO Tuesday/Wednesday/Thursday?
It did not show up until Friday, thus leading to another overdraft charge of $38.50! Then when i went to the bank to complain about it, they treated me like i was a Whacko, BUT they gave me back the money a few days later?!
They charge for even checking your balance, also for using ATM's AT THEIR BANK!?
I have since closed the account!
WHERE DO I GET HELP ABOUT THIS?Thank you for your feedback Is this review helpful?
DReviewed By delso Nov 15, 2016
The worst bank ever!!!!!
This bank decided to freeze my account while I was on vacation. When I called, they told me they froze my account because they needed to know if I was a U.S. citizen. After I had no choice but to answer them they said that had to wait 48 hr to get any money out. What joke of a Bank.Thank you for your feedback Is this review helpful?
KReviewed By Krismae76 Oct 25, 2016
I thought we'd use a local bank, but they are awful. I got called daily after opening a checking account by the sales person wanting me to buy life insurance. The bill pay is terrible compared to other banks. You can't pay bills directly to merchants. Twice in one month our payments have arrived late, and the excuse is they can't control the mail. I've never had this problem with any other bank, and it's embarrassing and a hassle. Run from M&T. I am.Thank you for your feedback Is this review helpful?
CReviewed By cipollanera Oct 4, 2016
If you want to have YOUR money held hostage, this is your place.....
On 9/29 I deposited a check written off a credit union in another state. The funds were deducted from the payer's account the same day. I was told by the teller with whom I deposited my check that it would be 2 business days., I am now told that there is a 4 day hold because it was written off a credit union. Then (same conversation) told the money, which is MINE and was DEBITED IMMEDIATELY from the other account will be credited to my account on 10/6 - one full week after my in-person deposit of the check. This is 2016, folks.
So, pray tell, all powerful owners and overlords of other peoples' money....when will you have accrued enough interest off MY money to go ahead and credit it to my account? Greedy bastards. The lot of you should be in jail.
I imagine they are all the same, but I will be shopping around...this is highway robbery.Thank you for your feedback Is this review helpful?