text:
Phantom Orchard, the duo of Zeena Parkins and Ikue Mori, is expanded with 5 performers representing some of the most exciting women in modern creative experimental music, releasing a surprising, riveting, and amazing album.
Phantom Orchard Orchestra
Trouble In Paradise
Label: Tzadik
Released in: USA
"Members of bands as diverse as DNA, Skeleton Crew, Electric Masada, Hemophiliac and Björk, Zeena and Ikue have been leading figures of the downtown scene since the early 1980s. Their fabulous duo project Phantom Orchard is expanded here with five of the most exciting and creative women working in experimental music today. Created in 2008 for a project organized by the SWR radio in Baden Baden, the music has plenty of mystery, an exotic beauty and an orchestral sweep. This is experimental music at its very best."-Tzadik
Related Categories of Interest:
Improvised Music
Electro-Acoustic Improv
NY Downtown & Jazz/Improv
Parkins, Zeena
Mori, Ikue
Staff Picks & Recommended Items
Septet recordings
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Shipping Weight: 5.00 units
Quantity in Basket: None
Label: Tzadik
Catalog ID: TZA-CD-7728
Squidco Product Code: 17147
Format: CD
Condition: New
Released: 2012
Country: USA
Packaging: Jewel Tray
Recorded live by Wolfgang Bachner/New Jazz Meeting 2008 at Tollhaus, Karlsruhe on November 28th (Tracks 2 and 3); Track 6 was recorded in Gare Du Nord, Basel on November 29th; Tracks 1, 4, 5, 7, and 8 were recorded in Frankfurter Hof, Mainz on November 30th.
Zeena Parkins-electric harp, acoustic harp
Ikue Mori-electronics
Maja Solveig Kjelstrup Ratkje-voice, electronics
Hild Sofie Tafjord-french horn, electronics
Sara Parkins-violin
Maggie Parkins-cello
Shayna Dunkelman-percussion
Highlight an artist name or instrument above
and click here to Search
Track Listing:
1. Over The Gap 9:28
2. Red Blue And Green 10:22
3. Sun Metal 6:43
4. Face 11:19
5. Inner Reflection 4:14
6. House For 7 4:05
7. Laughter In The Dark 6:42
8. Trap 5:49


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Makes 4 to 6 small servings
This colorful and delicious dish, served at room temperature, is typical of the small vegetable salads of China's East Coast. We serve it in the spring at Big Bowl.
1 tablespoon toasted sesame seeds
1-1/2 pounds fresh asparagus
1 tablespoon Japanese rice wine vinegar
1 teaspoon red wine vinegar
1 teaspoon fish sauce or light soy sauce
1 teaspoon sugar
1 teaspoon Dijon mustard
2 tablespoons fine peanut oil
1 tablespoon sesame oil
In a small skillet, toast the sesame seeds until golden, shaking the pan so they won't burn.
Trim and cut the asparagus into 2-inch lengths. Parboil them in 6 cups water for 2 to 3 minutes, depending on their thickness. Drain and run under cold water to stop the cooking. Dry thoroughly.
Mix together the vinegars, fish sauce, sugar, and mustard. Stir in the oils, combining as you would a vinaigrette. Toss with the asparagus. Sprinkle over the sesame seeds and serve.
Big Bowl Noodles and Rice
By Bruce Cost with Chef Matt McMillin
HarperCollins Publishers, 2000
Hardcover, $25.00
Color photographs
Recipe reprinted by permission.
This page created November 2000
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Climate Change Adaptation:
Aligning Funding with Strategic Priorities
GAO-11-876T: Published: Jul 28, 2011. Publicly Released: Jul 28, 2011.
Additional Materials:
- Highlights Page:
- Full Report:
- Accessible Text:
(202) 512-9338
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A 2009 assessment by the United States Global Change Research Program (USGCRP) found that many types of extreme weather events, such as heat waves and regional droughts, have become more frequent and intense during the past 40 to 50 years. According to the assessment, changes in extreme weather and climate events will affect many aspects of society and the natural environment, such as infrastructure. In addition, the Department of Defense found that climate change may act as an accelerant of instability or conflict, placing a burden to respond on militaries around the world. According to the National Academies, USGCRP, and others, greenhouse gases already in the atmosphere will continue altering the climate system into the future regardless of emissions control efforts. Therefore, adaptation--defined as adjustments to natural or human systems in response to actual or expected climate change--is an important part of the response to climate change. This testimony addresses (1) the actions federal, state, and local authorities are taking to adapt to climate change; (2) the challenges that federal, state, and local officials face in their efforts to adapt and actions federal agencies could take to help address these challenges; and (3) the extent to which federal funding for adaptation and other climate change activities is consistently tracked and reported and aligned with strategic priorities. The information in this testimony is based on prior work, largely on GAO's recent reports on climate change adaptation and federal climate change funding.
Federal, state, and local authorities are beginning to take steps to adapt to climate change. Federal agencies are beginning to respond to climate change systematically through an Interagency Climate Change Adaptation Task Force formed to recommend key components for inclusion in a national adaptation strategy. Individual agencies are also beginning to consider adaptation actions. For example, in May 2009, the Chief of Naval Operations created Task Force Climate Change to address the naval implications of a changing Arctic and global environment. Some state and local government authorities were beginning to plan for and respond to climate change impacts, GAO reported in 2009. For example, the state of Maryland had a strategy for reducing vulnerability to climate change, which focused on protecting habitat and infrastructure from future risks associated with sea level rise and coastal storms. In another example, King County, Washington, established a countywide flood control zone district to upgrade flood protection facilities and increase the county's resilience to future flooding, among other things. Federal, state, and local officials face numerous challenges in their efforts to adapt to climate change, and further federal action could help them make more informed decisions. These challenges include a focus of available attention and resources on more immediate needs and insufficient site-specific data--such as local projections of expected climate changes. The lack of such data makes it hard to understand the impacts of climate change and thus hard for officials to justify the cost of adaptation efforts, since future benefits are potentially less certain than current costs. GAO's October 2009 report identified potential federal actions for improving adaptation efforts, including actions to provide and interpret site-specific information, which could help officials understand the impacts of climate change at a scale that would enable them to respond. In a May 2008 report on the economics of policy options to address climate change, GAO identified actions Congress and federal agencies could take, such as reforming insurance subsidy programs in areas vulnerable to hurricanes or flooding. Funding for adaptation and other federal climate change activities could be better tracked, reported, and aligned with strategic priorities. GAO's report on federal climate change funding suggests that methods for defining and reporting such funding are not consistently interpreted and applied across the federal government. GAO also identified two key factors that complicate efforts to align funding with priorities. First, officials across a broad range of federal agencies lack a shared understanding of priorities, partly due to the multiple, often inconsistent messages articulated in different policy documents, such as strategic plans. Second, existing mechanisms intended to align funding with governmentwide priorities are nonbinding and limited when in conflict with agencies' own priorities. Federal officials who responded to a Web-based questionnaire, available literature, and stakeholders involved in climate change funding identified several ways to better align federal climate change funding with strategic priorities. These include a governmentwide strategic planning process that promotes a shared understanding among agencies of strategic priorities by articulating what they are expected to do within the overall federal response to climate change.
Feb 22, 2017
Grants Management:EPA Has Taken Steps to Improve Competition for Discretionary Grants but Could Make Information More Readily AvailableGAO-17-161: Published: Jan 23, 2017. Publicly Released: Feb 22, 2017.
Feb 15, 2017
High Risk:Federal Management Challenges Related to Indian Energy ResourcesGAO-17-434T: Published: Feb 15, 2017. Publicly Released: Feb 15, 2017.
Feb 8, 2017
Grants Management:EPA Partially Follows Leading Practices of Strategic Workforce Planning and Could Take Additional StepsGAO-17-144: Published: Jan 9, 2017. Publicly Released: Feb 8, 2017.
Jan 23, 2017
Endangered Species Act:U.S. Fish and Wildlife Service's American Burying Beetle Conservation EffortsGAO-17-154: Published: Dec 22, 2016. Publicly Released: Jan 23, 2017.
Jan 19, 2017
Military Base Realignments and Closures:DOD Has Improved Environmental Cleanup Reporting but Should Obtain and Share More InformationGAO-17-151: Published: Jan 19, 2017. Publicly Released: Jan 19, 2017.
Jan 17, 2017
Financial Assurances for Reclamation:Federal Regulations and Policies for Selected Mining and Energy Development ActivitiesGAO-17-207R: Published: Dec 16, 2016. Publicly Released: Jan 17, 2017.
Jan 12, 2017
National Park Service:Process Exists for Prioritizing Asset Maintenance Decisions, but Evaluation Could Improve EffortsGAO-17-136: Published: Dec 13, 2016. Publicly Released: Jan 12, 2017.
Jan 3, 2017
Climate Change:Improved Federal Coordination Could Facilitate Use of Forward-Looking Climate Information in Design Standards, Building Codes, and CertificationsGAO-17-3: Published: Nov 30, 2016. Publicly Released: Jan 3, 2017.
Dec 6, 2016
Army Corps of Engineers:Better Guidance Could Improve Corps' Information on Water Resources Projects Undertaken by Nonfederal SponsorsGAO-17-97: Published: Dec 6, 2016. Publicly Released: Dec 6, 2016.
Dec 1, 2016
Renewable Fuel Standard:Program Unlikely to Meet Production or Greenhouse Gas Reduction TargetsGAO-17-264T: Published: Dec 1, 2016. Publicly Released: Dec 1, 2016.
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text:
Top Definition
a former member of toocool, was wwe tag champions with rikishi, and called the worm
toocool member scotty too hotty
by nick September 19, 2008
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


text:
The Housing Committee scrutinises the Mayor's role and record in delivering the private, social and affordable homes London needs.
Housing Committee
Recent work
- Investigated how to stabilise the private rental sector to give tenants more security
- Explored how to improve student accommodation in the capital
- Looked at how communities, housing associations, councils and developers could work together to make a success of estate regeneration
- Examined the role of overseas home buyers in the capital's housing market.
The Committee is currently investigating what more the Mayor could do to ensure that Londoners get the best housing deal from TfL land. It will also consider the key issues in developing the kinds of sites TfL has available.
Leonie Cooper AM will also be undertaking a rapporteurship into Encouraging Biodiversity in New Housing Developments on behalf of the Housing Committee examining how to encourage a more strategic and longer-term approach to green infrastructure delivery and investment in London developments.
Committee meetings
Browse meetings and agendas for this committee and to check out further information relating to the committee, including terms of reference.
Latest publications
- At Home with Renting: Improving security for London's private renters - stabilising the private rented sector
- Providing affordable homes for rent - letter to the Mayor about how to support the building of new affordable homes for rent in London
- Who can afford to live and study in London? - letter to the Mayor on student accommodation
- First Steps on the Ladder – is shared ownership working?
- Knock It Down or Do It Up? – making estate regeneration work for all
- Letter to the Mayor on gypsy and traveller sites
Feedback and news coverage
In the news
- London housing: conflict and consensus about landlords and rents - The Guardian
London's student accommodation 'too focused' on catering for an affluent, overseas market, Mayor Boris Johnson warned - The Independent
Luxury accommodation: it's the new add-on to student debt woe - The Observer
What will success look like under Sadiq Khan - The Guardian
Looking at London's biodiversity - London Live
Committee members
- Andrew Boff (Chair)
- Tom Copley (Deputy Chair)
- Sian Berry
- Leonie Cooper
- Tony Devenish
- Nicky Gavron
- David Kurten
Contact the Housing Committee
If you have a media enquiry about the Housing Committee, please contact:
External Relations Officer
Sonia Labboun
[email protected]
020 7983 5769
If you have a general query about this Committee and its work please contact:
Scrutiny Manager
Lorraine Ford
[email protected]
020 7983 4394
If you have a query about the Mayor of London's housing work, please contact 020 7983 4000.


text:
Who fancies the Isles of Scilly next year? Lots of you, that's who. If my inbox is anything to go by, cash-strapped families across the country are planning to head for the UK's warmest and most southerly point, hoping for a subtropical holiday without having to go abroad.
First, there's Simon Laurence, who wants to know whether the islands are a good place to take his kids camping. The answer is yes, so long as you thoroughly waterproof your sprogs beforehand. (We spent two weeks in the Scillies in August and I'm still drying my boys out.)
The best campsite – and this is a secret, so please don't spread the word, Simon – is Troytown Farm (01720 422360; troytown.co.uk) on remote St Agnes, which costs from £9 per person per night in high season. Think home-made ice cream, sandy beaches and rocky coves, not to mention a gloriously family-friendly pub nearby.
But if, like mum-of-three Jay Liddle, you fancy something a little more upmarket (ie with a roof), scillyonline.co.uk has some well-priced accommodation options, including secluded cottages and family hotels. Better still, check out the Flying Boat Club, which opened last year on the isle of Tresco (tresco.co.uk): a clutch of stylish beach houses with an indoor pool, spa, bar and restaurant. Prices start at around £1,375 a week for a house sleeping six.
But the Scillies aren't just for summer. How about a break out of season? Skybus has just announced a new winter flight programme from Exeter to St Mary's (ios-travel.co.uk) with return fares at £215 (£140 for children). Check out its new short break package deal with accommodation at the Boat Club, too.
Winter in the Scillies? That's not such a bad idea. It's still the warmest place in England, even when it rains.
- More about:
- Camping
- Cornwall
- Ice Cream
- Restaurants


text:
ATLANTA - It got the tiniest bit hairy there for a second, but Henrik Stenson held on, as he'd done from Day 1 at the Tour Championship, to claim the richest prize in golf in the FedEx Cup. Stenson, who at one point on Saturday had a lead as high as nine strokes, saw his margin dwindle to but a single stroke late in the round Sunday, but managed to stay steady and win two fancy new trophies.
Stenson entered the day at -11, four strokes ahead of playing partner Dustin Johnson. And when Johnson birdied the third to close within three, it appeared the game was afoot. Indeed it was, but Johnson wouldn't be involved.
Instead, it was rookie Jordan Spieth, continuing his dream season, who played absolutely out of his mind. Speith recorded seven birdies over 10 holes in the middle of the round, and when Stenson had trouble off the fairway on 14, Spieth was, for a moment, one stroke off the lead in the Tour Championship.
It wouldn't last. Spieth bogeyed 17 at almost the exact moment Stenson birdied 15, and that was the margin of victory that would stand up. From there, it was a virtual victory lap for Stenson, made all the more smooth when Johnson triple-bogeyed 17. That mess came at the same time as Stenson crafted a perfect approach shot, one Johnny Miller in the booth called "absolutely flawless." The cheers rang out over the 17th and 18th holes, and from there it was just a matter of playing out the string.
Stenson now sets himself up as one of the players to watch going into next year's majors season. It's a long haul until April, but Stenson has about ten million new ways to occupy his time until then.


text: 3A Toys' Doctor Doom Comes In Three Shades Of EvilMike Fahey10/27/14 11:30am494EditPromoteGo to permalinkI look at the three colorways (color variants) of 3A Toys' Doctor Doom figure and I see several hundred dollars ready to evacuate my bank account. Evan Narcisse looks at them and sees pointy shoes. Doom is not pleased.


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Introducing holidays to Skiathos Town
Beaches, sumptuous Greek dishes and The Castle of Skiathos are all encapsulated within this wonderful town which is very much the vibrant heartbeat of the island, emanating a charm from the Old Town while exuding exuberance from the more modern bars and clubs not far away. You'll find a wealth of attractions and activities to get involved with during Skiathos Town holidays and with a huge amount of natural beauty to admire you'll be well-served even when you're lying on the sun-splashed beaches, just happy to watch the world pass by. However, another exciting prospect for anyone venturing out to Skiathos Town is its connectivity to other locations on the island, the town itself being a transport hub for anyone wishing to explore.
Top Attractions
As well as putting you in a good location for adventure through the varied terrain of Skiathos, an island of intriguing coastal allure and mountainous landscapes, you will also be able to take a ferry to different parts of Greece, including Skopelos and Volos. Before doing so however, you may want to settle down for a snack or two to fuel your excursions, the colourful local cuisine being the ideal way to fill the belly.
Taverns and bars are also numerous so you can pick up a couple of cocktails to ease in the evenings while enjoying the sunset during your holidays to Skiathos Town, if you so wish. Enjoy peaceful days on the gloriously sandy beaches before heading out on the town in the evenings, get the kids enrolled in a water sport or two to keep them satisfied or traverse antiquated lanes, window-shopping in the quaint little stores which line the streets – holidays in Skiathos Town are full of possibilities, no matter what you're planning for your next adventure!


text:
Wood Decking - Wooden and Timber Decks from i-dec
Timber decks are becoming a fashion statement in South African homes, transforming every outdoor area into the quintessential entertainment area. It is easy to see why an attractive wooden deck creates a unique aura of comfort. Well-planned wooden decks can create a beautiful area, which feels very much part of your house but brings luxury to any outdoor space. What better place to have a deck than in this glorious sunshine country where your deck will become the focal point for all alfresco dining, pool relaxing sunbathing, braais and parties.
Choose from a variety of options and possibilities. Expand on your property and add a much needed pool deck, sundeck, veranda, Jacuzzi decks and garden pathways to your home. What ever your needs we will strive to accommodate.
i-dec specializes in creating stunning wood decking and timber decks, understanding this by manufacturing high end products, i-dec ensures that its clients get the best of the best. i-dec provides it's clients with a variety of quality timbers for it's magnificent decks. Specially treated wood ensures you have a durable product which is made to last. i-dec supplies a combination of local and imported timbers to suite your every need. From stunning Red Iron Bark, to Grey Iron bark, Teak, Massaranduba, Saligna, Balau, Meranti and many others. i-dec prides itself on its professionalism, quality of service and aftercare offering a year guarantee with an additional maintenance plan on offer.
If you looking for decks including screw-less pool and jetted spa decks, look no further than i-dec.
Whats Hot
Transform your garden ready for the summer with a beautiful deck at a great offer!!!
- A Grade Red Iron Bark normally R1350 p/m2 for July and August only R1250 p/m2. T&C apply. Promo only available to installations over 20m2. Based on a square installation. More complex installations may incure additional charges.
- Prepare your timber this winter for the coming summer months with this great offer. 15% off all Maintenance. T&C apply: subject to decks over 20m2. Johannesburg area only. Subject to availability


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921 Wesley Avenue, Ocean City, This vacation rental property sleeps 4 with 1 bedrooms and 1 baths. 921 CONDOMINIUM This condo building is located only 1 and 1/2 blocks to the beach/boardwalk between ninth and 10th Streets on Wesley Avenue. Features include one bedroom units with → Read More
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From a New York Post article today headlined Dave crony collects 'money for nothing':
Gov. Paterson's former economic-development czar, Avi Schick, stepped down from his post at the helm of the Empire State Development Corp. in January -- but, astonishingly, continued to quietly draw his $213,000 annual salary for eight more months, The Post has learned.
Schick, who has close ties to Assembly Speaker Sheldon Silver, managed to hang on to his full salary -- more than what the governor earns -- in return for advising Paterson on lower Manhattan issues, said ESDC spokesman Warner Johnston.
The ESDC revealed Schick's continuing compensation to The Post last week after more than a month of requests, and just days after he was removed from the payroll on Sept. 11 so that he could begin a new job with a law firm that began three days later.
It was unclear on what specific issues Schick advised Paterson.
He could not be reached for comment, and state officials would only say that he was asked to stay on during a leadership change at ESDC over the summer.
..."People assumed he wasn't paid because no other LMDC chairman had ever received a salary," said a well-placed lower Manhattan source.
Actually, if Schick could be described as anyone's "crony," the person would be Gov. Eliot Spitzer, who appointed him.
But if Schick resigned in January, his role "over the summer"--after CEO Marisa Lago left--didn't kick in until well after his resignation.
Monday, September 21, 2009
Post: ESDC paid Schick for eight months after resignation
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text:
After-School Programs
Bricks 4 Kidz® after-school classes build on the universal popularity of LEGO® Bricks to deliver high quality, educational play. Every class is a fun, enriching experience for your child, using the classic bricks loved by generations of children.
In-School Workshops
A Bricks 4 Kidz® workshop uses LEGO® Bricks that kids love, to deliver hands-on lessons correlated to cross-disciplinary curriculum objectives. The Bricks 4 Kidz® approach to learning is imaginative, multi-sensory and fun, creating a dynamic learning experience for your students.
Bricks 4 Kidz® camps are a fresh and fun way for kids to spend their school or holiday break! Children will enjoy using LEGO® Bricks to build specially-designed models, play games, explore the world of engineering, architecture and movie-making.
Experience our exciting Jr. Robotics and Advanced Robotics classes! Build a motorized model and watch it come to life using simple LEGO® WeDo® software. As your skills improve, advance to LEGO® EV3 Mindstorms® classes for more challenging robot-building and programming!
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Experience our exciting Jr. Robotics and Advanced Robotics classes! Build a motorized model and watch it come to life using simple LEGO® WeDo® software. As your skills improve, advance to LEGO® EV3 Mindstorms® classes for more challenging robot-building and programming!
We learn, we build, we play with LEGO® Bricks
BRICKS 4 KIDZ® Des Moines, Ames, Waukee Group
Providing programs for Des Moines, Ames, Indianola, Altoona, Pleasant Hill, Bondurant, Polk City, Granger and the city of Waukee
We enthusiastically joined the Bricks 4 Kidz® family in November 2011. Already fans of the program introduced by the first Bricks 4 Kidz® owner in the area and huge LEGO® enthusiasts we are thrilled to have the opportunity to expand the Bricks 4 Kidz® program here in Central Iowa.
About Bricks 4 Kidz®…
Bricks 4 Kidz classes provide an extraordinary atmosphere for children, where we learn, we build, we play… with LEGO® bricks. Programs are built around our proprietary model plans, designed by engineers and architects, with exciting themes such as space, construction, and amusement parks. Our specially designed project kits and theme-based models provide the building blocks for the Bricks 4 Kidz approach to educational play. At Bricks 4 Kidz, we believe that kids learn best through activities that engage their curiosity and creativity.
We offer activities for children ages 3-13+, including:
After School Enrichment Classes
Bricks 4 Kidz Night Out
Bricks 4 Kidz Birthday Parties
Summer Camps: 2016 CAMPS ONLINE NOW- REGISTER TODAY!
A Bricks 4 Kidz® camp is a fresh and fun way for kids to spend their school break! With specially-designed Bricks 4 Kidz® models, LEGO® games, challenges and the ever popular collective projects to serve as creative inspiration during free-play, the kids are always LEARNING, BUILDING and PLAYING. Camps are specially designed for kids ages 5-12 and are staffed by trained, screened Bricks 4 Kidz® teachers.
Our camp programs provide a safe, relaxed learning environment where initiative is invited and self-expression is celebrated. Model building provides opportunities for problem-solving and helps kids develop an appreciation for how things work. All this takes place while kids are having fun and socializing in a non-competitive atmosphere.
- DES MOINES- WALNUT ST. SCHOOL- Downtown Des Moines
- DES MOINES- GRACE UNITED METHODIST CHURCH- Cottage Grove Ave.
- DES MOINES- ST. JOSEPH'S CATHOLIC SCHOOL-33rd St.
- WAUKEE- SOUTH MIDDLE SCHOOL- L.A. Grant Parkway (Hosted by Waukee Community Education)
- WAUKEE- PRAIRIEVIEW SCHOOL-University Ave (Hosted by Waukee Community Education)
- INDIANOLA PARKS AND RECREATION- City Hall (Hosted by Indianola Parks and Recreation)
- BONDURANT- ANDERSON ELEMENTARY- Garfield St.
- Introduce engineering and architecture principles
- Explore math and science concepts
- Increase general knowledge through discussions related to each model
- Develop social/emotional skills such as patience, teamwork and communication in the process of completing a project
- Enhance self-esteem by solving problems and completing projects
- Improve fine-motor skills as children manipulate small components
- Utilize multiple learning modalities to engage visual, kinesthetic and auditory learning styles
- Teach important classroom skills such as organization and following directions
- Foster an appreciation for how things work
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Hotfrog Singapore provides information regarding Tomi Sushi - Novena in Singapore. Tomi Sushi - Novena is located at 238 Thomson Rd, Novena Sq, Singapore 307683 and provides Social services. Contact them on 6255 2355 or by visiting them on their website http://www.tomisushi.asia.
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General Biology with Lab
This free and open online course in General Biology (with Lab) was produced by the WA State Board for Community & Technical Colleges [http://sbctc.edu/].General Biology is intended to leave the student with an integrated view of the living world including the nature of sciences, evolution of biological organization, composition and organization of living substances, metabolism, control, reproduction, heredity and ecological relationships. This class meets the A.A. degree lab science... More
Material Type: Online Course
Technical Format: HTML/Text
Date Added to MERLOT: November 28, 2011
Date Modified in MERLOT: August 22, 2012
Submitter: Cathy Swift
Reviewed by members of Editorial board for inclusion in MERLOT.Editor ReviewVery good quality; in queue to be peer reviewedavg:
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If I Fire My Bankruptcy Attorney, What Fees Will I Owe?
If you fire your bankruptcy lawyer, you may be able to get a refund of attorney's fees that are excessive or for work that your lawyer has not yet done.
If you fire your bankruptcy lawyer, whether or not you can receive a refund of your fees will depend on:
- the terms of your retainer agreement (the contract you sign when you hire an attorney)
- the rules of your state bar association
- how much work the attorney has performed, and
- whether you filed for Chapter 7 or Chapter 13 bankruptcy.
(Learn more about whether you should fire your bankruptcy attorney.)
What Are the Terms of Your Retainer Agreement?
In most cases, when you hire a bankruptcy lawyer, you will sign a contract called a retainer agreement. The retainer agreement will often set forth:
- the rights and responsibilities of the attorney and the client
- the scope of the work the attorney must perform
- the attorney's fee, and
- what happens if the attorney-client relationship ends.
Your retainer agreement probably includes provisions that address what happens to your fees if you fire your lawyer. For this reason, it's a good place to start when determining whether or not the attorney must refund some or all of your fees.
Keep in mind that the retainer agreement may list some attorney fees as nonrefundable. But this doesn't necessarily mean that you can't get them back. Even if your retainer agreement lists your attorney's fees as nonrefundable, your state bar association's rules may not allow the attorney to keep unearned or excessive fees (discussed below).
Review the Rules of Your State Bar Association
The state bar association is the organization that regulates the professional conduct of attorneys. All state bars have rules of professional conduct that attorneys must follow. In most cases, these rules prohibit attorneys from keeping unearned or excessive fees. Even if your retainer agreement states that the fees you paid are considered earned upon receipt or labeled as nonrefundable, your attorney isn't entitled to keep those fees if they are excessive or unreasonable.
Whether an attorney's fees are excessive or unreasonable depends on many factors including:
- how much work the attorney did
- the difficulty of your case
- the length of the attorney-client relationship, and
- the amount of fees you paid.
Has the Attorney Filed Your Bankruptcy Case?
In many cases, attorneys charge a flat fee to handle your bankruptcy from start to finish. This generally includes:
- preparing your bankruptcy paperwork
- filing your case
- representing you at all required hearings such as the meeting of creditors (also called the 341 hearing), and
- making sure that you receive your bankruptcy discharge.
If your attorney has not filed your bankruptcy case, whether or not you are entitled to a refund of some or all of your fees typically depends on:
- the amount of fees you paid, and
- how much work the attorney has done so far (for example, your attorney may have already spent a significant amount of time preparing your bankruptcy paperwork).
Did You File for Chapter 7 or Chapter 13 Bankruptcy?
The amount of fees you owe can also depend on whether you filed for Chapter 7 or Chapter 13 bankruptcy.
Attorney Fee Refunds in Chapter 7 Bankruptcy
In general, bankruptcy attorneys won't file a Chapter 7 case until you have paid all of your fees in full. (Learn about average Chapter 7 attorney fees.)
If you fire your lawyer after he or she files your Chapter 7 bankruptcy, the amount of fees you may be entitled to get back will usually depend on:
- how far along the case is, and
- whether your attorney has provided competent representation (done everything he or she was supposed to) up to that point.
Attorney Fee Refunds in Chapter 13 Bankruptcy
In Chapter 13 bankruptcy, you typically don't have to pay all of your fees in full before your attorney files your case. Many attorneys will require a certain portion of the total fee upfront. But the remainder is paid through your Chapter 13 repayment plan. (Learn about paying your attorney fees through your Chapter 13 plan.)
You must start making Chapter 13 plan payments shortly after filing your case. But the bankruptcy trustee doesn't distribute your payments to your creditors (including your attorney) until the court confirms (approves) your plan and your attorney's fees.
If you fire your attorney before the court confirms your bankruptcy, the trustee won't pay the remainder of your attorney's fees without a court order. But keep in mind that depending on the amount of work your attorney has performed, he or she may file an application with the court to receive the remainder of the fees.
What Can You Do If Your Attorney Doesn't Refund Unearned Fees?
If you fire your bankruptcy attorney, you can often negotiate the amount of fees he or she will get to keep. But if your lawyer refuses to refund the unearned or excessive portion of his or her fees, you can:
- sue the attorney in small claims court, or
- report the attorney to the state bar for disciplinary action.
Talk to a Bankruptcy Lawyer
Need professional help? Start here.
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text:
These past couple weeks have been crazy, what with the first-ever #CoronaHackathon last weekend and the first-ever Corona meetup in Chicago last night. We're always thrilled to get out of our cave every once in a while and see the faces of people who inspire us to keep on making Corona SDK the best mobile app platform on the planet.
Nevertheless, we still must ask…
What would you like to see
at a future Corona event?
This includes geographical suggestions too. We're all ears… 🙂


text:
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Lot 93: (Pr) DORE BRONZE ORMOLU 16- LIGHT TORCHIERES
Fall Antiques & Collectibles Auction
by Echoes Antiques & Auction Gallery
25 October 2016
Seaford, NY, USALive Auction
Looking for the realised and estimated price?
Description: WINGED CREATURES & CLAW FOOT BASE ; AFTER REGENCY POSSIBLY WILLIAM COLLINS ; SOLD BY -35" x 92"
Browse more items


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Clients taking our classes will find:
- Class handouts
- Recorded class lectures
- Topic specific discussion forums
- Homework forms, grade reports, and solutions
- Links to the online classroom for the live lectures
- Opportunities to participate in open study sessions
- Download PDF files of previously emailed study questions
- Practice for the exam with quizzes of randomly selected questions
All Bowen EHS clients who take our online classes or in-person workshops are automatically enrolled in a Premium Membership to the Bowen EHS® Member Center. See your course description for membership length.
It's here! Premium Memberships - find out more!
We also have FREE Memberships.


text:
(based on 3 reviews)
Ratings Distribution
5 Stars
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of respondents would recommend this to a friend.
Reviewed by 3 customers
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my great commentary
By rach sweetie
from sterling hgts, michigan
About Me Practical, Stylish
Best Uses
Comments about Acrylic Bracelet Holder:
it looks great on my dresser has enough room to hold all my bracelets and I have gotten compliments from friends on how nice and neat it happens to be.
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
Love this
By lovethecatskills
from Monticello, NY
About Me Classic, Comfort-Oriented, Practical
I make and sell jewelry, I actually use this to display my stretch beaded rings. and another for my bracelets
I am going to buy at least one more
By Kathy
from Upland, CA
About Me Career
The clear acrylic allows the beauty of my bracelets to show through. It is a simple yet elegant way to display them so I can easily find what I am looking for. It keeps my jewelry organized.


text:
A pair of padded bags for safe and secure travel with your MTB wheels. Evoc Wheel Bags feature a durable construction for effective protection and reinforced pads to cover the hubs. Also takes 29er wheels.
Thank you for visiting Evoc Mountain Bike Wheel Bags - Pair Soft Bike Bags on oakleysbikes.co.uk
We bring the products from many websites to one website for you to search, save and compare.


text:
Let the Right One In
Easy Money
The Girl Who Kicked the Hornet's Nest
Patrik 1,5
The Girl Who Played With Fire
Så som i Himmelen
Lilya 4-Ever
All Gunnar Carlsson films
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2017 FANDANGO MOVIES.


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average rating: -- / 10
firma windykacyjna More willingly than jumbled testimonies became known regarding his / her let somebody see participating in chain camping in contradiction of various fight spouse, division tops moreover breasted way up side, Mayweather was placed defeat with Aol World-wide Sports activity Spine Katie Couric to help examine numerous matters. Regularly at some point in uttermost occasions when the visitors is situated typically surging a single tendency with make somewhere your home permit the location furthermore being foremost birthplace towards hamlet, you'll arrive at a roundabout with practically simply no visitors starting to the lead furthermore the medial side toll road interchange which usually must hand over wayyield accomplishes get anybody to provide strategy to. They develop goal near evasion then you can put off with pause as well as put off while they momentum throughout.
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I wanna cook
Cooking something?
Whatever it is, sell a few portions on Super Marmite! It's a great way to interact with your local community and to get real feedback on your cuisine :)Post a meal


text:
11 November 2012
11 November 2012 Last updated at 18:55 GMT
A two-minute silence has been held to remember members of the British and Commonwealth's armed forces who have died during conflicts.
The Queen was joined by Prince Phillip and the Duchess of Cambridge at the Cenotaph on Remembrance Sunday.
Nicholas Witchell reports.


text:
WinRunner alternative for Linux?
Bob Johnson
Posts: 1
posted 12 years ago
Does anyone know of an alternative to WinRunner that runs on Linux based platform. Specifically for automating Java apps.
Ilja Preuss
Posts: 14112
posted 12 years ago
What features do you need?
The soul is dyed the color of its thoughts. Think only on those things that are in line with your principles and can bear the light of day. The content of your character is your choice. Day by day, what you do is who you become. Your integrity is your destiny - it is the light that guides your way. - Heraclitus


text:
The Honeywell RLV4300A is a low-cost digital thermostat that home owners can install themselves. This thermostat is specifically designed for electric baseboard heat, convectors, radiant ceilings, and fan-forced heaters. As a result this is not a thermostat for use with other types of heating or air conditioning. Installation is fast and easy with only two wires that need to be connected. Separate programming schedules can be set for weekdays and the weekend, allowing two sets of 4 program periods to be set. Memory Setting Retention allows the thermostat to retain its settings in the event of a power outage, and TRIAC silent switching ensures an accurate temperature in the house.
- Separate Programming for the Weekdays and Weekend
- Up to 4 program periods per day
- Fast, easy two-wire installation
- Energy Savings
- Backlit Display
- Memory Setting Retention
- TRIAC silent switching
- Compatible with electric baseboard heat (240V), convectors, radiant ceilings and fan-forced heater
- 1-Year Warranty
Add New
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text:
Israel eases restrictions on Gaza as part of truce
JERUSALEM In a major concession to Gaza's Hamas leaders Monday, Israel dropped its five-year ban on construction materials crossing into the territory and raised hopes there that rebuilding could begin following a damaging eight-day Israeli air campaign.
The easing of restrictions is an outgrowth of the cease-fire that ended the airstrikes and months of daily rocket fire from Gaza at Israel. Contacts mediated by Egypt to follow up the truce produced the concession, and Israel promised to keep easing the lives of Gaza's 1.6 million residents, as long as Israelis were no longer targeted by rocket fire.
How long the new arrangement holds could serve as a test case for the brittle truce between the bitter enemies. It also reflects a new power equation, with neighboring Egypt under the control of the Muslim Brotherhood, the parent group of Hamas.
Israel and Egypt imposed a land and naval embargo on Gaza after Hamas overtook the territory in 2007. Although Israel eased the restrictions in 2010, building materials such as cement, gravel and metal rods were still largely banned because Israel claimed militants could use them to make fortifications and weapons.
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After the utter gluttony of last year, 2013 has begun with thin pickings. Even the darts is disappointingly slimline these days, and you can't really get less flesh on the bone than Frankie Dettori in Celebrity Big Brother (Channel 5, from Thursday).
After the nightmare of watching the racing pundit John McCririck on one of the reality show's previous incarnations, it would be good for the Italian to represent the sport of kings in a more acceptable light, even if it doesn't make great TV.
But he has probably only taken up residence because he is serving a six-month ban for abuse of prohibited substances. You might have thought he couldn't go any lower, but then he is very short.
So the only ride Dettori can hope for in the next three weeks – apart from a Page Three thoroughbred called Banghard and a load of old soap opera nags – is on the back of Neil "Razor" Ruddock, who is styling himself as a "grizzly bear". If Dettori is not quite full-size, the old footballing hardman has swelled to the size of two or three men. They are both down in the Big Brother basement already, and must have come at a bargain price for the pair.
To relieve the new-year tedium there was a curiosity about racing in the streets of London. It's not strictly sport, perhaps, but then nor is ballroom dancing or darts. The Millionaire Boy Racers (Channel 4, Thursday) have teams of men looking after the cars they bring over from the Emirates, fans line the pavements to catch a glimpse of the motors and the "carparazzi" are on hand to film the action.
Life must be dull in the desert. You can buy a few racehorses and football clubs, but it seems the only way to beat the boredom is to spend the summer in London racing high-performance cars around Knightsbridge. The only problem is there's no room in the boot to hold all the shopping.
In Matt Rudge's fine programme the local residents decry what they call "the Arab supercar season". It's a case of posh people getting upset about foreigners who have even more money than they do, but presumably they have fallen on hard times and had to rent out their summer retreats and stay in town.
Diana Gaskill sits in a basement flat while the cars roar past 50 times a day for 12 hours or more, and when they park, they rev the engine for five minutes. At least they don't have to worry about the price of petrol. There are residents' meetings and letters to embassies but no one actually speaks to the drivers. Maybe they just can't make themselves heard, and you wouldn't want to get in the way.
It's remarkable these souped-up cars accelerating up to 80mph have not killed anyone. Perhaps it helps that the cars are all bright pink and turquoise and canary yellow.
Eventually the police start pulling them over, but there is only one winner in this "battle of the fast and the furious". The only other thing that annoys the drag racers, strangely, is noise. In one (literally) priceless moment, Rashid from Dubai is cruising through Westminster in his £525,000 Lambo Aventador when Big Ben's chimes startle him.
"May God silence his noise," he hisses over the roar of his engine. Ask not for whom the bell tolls – soon he will have to go home, grow up and ring the changes in his life. But there are plenty more boy racers waiting in the gull wings.
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text: Secondary School Physics 5 points Previous question Next question What is main reason in conversion of mechinical energy to electricalenergy? 2 Ask for details Follow Report by mayank121 29.08.2014 you want the reason why energy is converted OR you want the physics principle - how it is converted. i want principle Log in to add a comment


text:
guy drains his main vein.4.17 / 5.00 7,781 Views
( Original ) Nesia Legend of Cosieda Episode 1
The first episode of my original anime3.96 / 5.00 2,952 Views
Godians Fight
Two Men Fight to the Death!4.15 / 5.00 2,112 Views
I strongly dislike Spaceboy
It's so bad it became funny then unfunny in a matter of seconds. What did I just say?? Ok I'm tired and confused so just ignore me.
...there's a place for ALPHAs.
wtf was that
All I saw was some guy driving in his car in a tie dye background. You should've called it gayboy. Fuck this shit!
The voices were really well done and very well timed as well. I especially loved the choice of music. The story is good because it does keep me wanting to know what happened and what they were supposed to find, and it was overall an amusing watch.
im probably going to take it down and revamp everything, this was actually a really old project i started a long time ago, jus submitting it to see how ppl respond to it. so i will finish it actually and make everything much cleaner, thank you for reviewing
I Saw too much of those...
first a found them interesting but now every 15th movie is made likje a game...and every 3rd of those is final fantasy...


text:
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This review is from: ZALMAN CNPS12X 120mm Long Life Bearing High Performance Triple Fan CPU Cooler
Pros: its big and plenty of airflow. probably one of the best short of liquid cooling. blue is my favorite color. and its not loud. even with 3 fans
Cons: its BIG. if you want 4 sticks of ram dont buy it. i had to use both channels A and B of my ran just so i can fit the cooler in the case. but no big worries. it is what it is. it wont get 5 eggs because i cant use the other 2 A and B slots of my ram. im useing the ASUS sabertooth 990 MB
Other Thoughts: i suggest buying a smaller cooler. zalman will always have a place in my case and they did a good job at explaining how big it was in the description. but i didint realize how big it was untill i saw the box. and it was nearly the size of my head. LITERALLY. like a 7 year olds head. its huge. its as tall at a 12FL oz glass bear bottle. pretend your PSU is your cpu heat sink. THAT BIG.READ FULL REVIEW
This review is from: Cooler Master HAF 922 - High Air Flow Mid Tower Computer Case with USB 3.0 and All-Black Interior
Pros: its big guys. plenty of room for your massive everything. alot of airflow. you wont be mad you bought it unless you want to put it in a small closet or something.
Cons: the top fan just went bad. it went POP literally. POP and it scared the **** out of me because i just built the computer. the fan is bad i cant use it. its not the cases fault but sorry cool master your name is on the fan. if this is the normal problems of building a computer and accepting problems i can deal. fan arnt expensive. but really!?. i never thought a fan could pop like that. and when i say pop i mean take a sandwhich bag and pop it. THAT LOUD.. made me jump. ppl in the other room. wanted to know if my computer exploded.
Other Thoughts: all around good generic case. plenty of room. plenty of airflow.READ FULL REVIEW


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post #1 of 2 Old 01-19-2009, 12:13 PM Thread Starter
Safe ways of getting rid of lime buildup.
I thought this article might be helpful for someone. I know It helped me clean the lime off of my hood and light.
There is nothing more irritating than not being able to see the comings and goings in your fish tank. Watching the interactions of fish and other marine animals can be relaxing, educational and help you to monitor the condition of the tanks inhabitants. When the glass or other parts of the aquarium, like the heater or lights, begin to develop white stains on them you need to act swiftly to remove them. But what exactly are the white stains ? Why do they appear and how can you remove them for good ?
The white stains are lime deposits or calcium and magnesium carbonate. Lime deposits form when the water that is used is described as hard water. Hard water is water that has a higher than normal amount of minerals in it. These minerals are mainly calcium and magnesium that derive from limestone or chalk in the case of calcium and dolomite in the case of magnesium.
Although the water is safe for the marine life in your fish tank, the white stains make the fish tank unsightly. Unfortunately there is nothing you can do about the water if you live in an area that has hard water. However it is very easy to remove limescale.
Lime scale or calcium carbonate reacts with any acid to form carbon dioxide. This has the effect of dissolving the white stains. Many standard household cleaning products will remove calcium carbonate but it is not advised to use them on your fish tank. These products generally have many chemicals which may harm your fish. The simplest solution is to use vinegar or even lemon juice on the glass and other equipment during a normal cleaning cycle as this will remove the lime scale but will not affect the marine life.
If the water has a lot of calcium or magnesium then you will have to do this every time you clean the tank but it is quite easy and fast to do.
Article Source: Adrian Whittle - EzineArticles.com Expert Author
~9 Swordtail's
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post #2 of 2 Old 01-19-2009, 02:23 PM
Great article. Very nice of you to post it, look forward to reading more from you.
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© Copyright 2017 GuruGuy. All rights reserved.
Status: Finished
Genre: Mystery and Crime
Can you please tell me who is a chaperone? I don't know.
The gang had been living... - I think it would be 'without any tension.' you wrote it as 'with'.
...new language after feeling confident to...- you misspelt it to confidant.
And, if Mia is dead, how did she helped the entrapped Riveras to escape? That's a big blunder. Edit it. A big blunder.
Other than these few mistakes, your creation is a sure winner. Absolutely breath taking. Compelling a reader to read. I mean, its sooo nice.
All the best.
Keep writing.
I think, you would have written a whole novel using this plot!
First off, thank you for reading and enjoying my story. To be honest I didn't edit it or proofreading it. Chaperone is someone who follows you everywhere you go; to protect you or lookout for you. If you're asking who's the chaperone it is Ewan, the one who's been with Colin the whole time. I think if you read carefully Genevieve had the room key the whole time. Thanx for the comment!
it was pretty gripping, i love the end. you write really good man, keep it going
I found the story line intriguing. Other than the few thigs listed above, the only other thing I would point out is that you left out a couple letters to turn things into adjectives. For example, when you say he was 'replaced with a cold-blood side of himself', it should be 'replaced with a cold-blooded side of himself'. Other than those few things it was good. :)
lykd it so much gg kmu
Compelling, simply riveting. An unusual storyline makes it "one of a kind". It is also very detailed and indepth.
I particularly enjoy Colin's lines. His character is "powerful".
A ground-breaker as always!
I never thought a short story could be so amazing! It's so action packed! My eyes were literally glued to the screen!
Book / Action and Adventure
Poem / Poetry
Book / Action and Adventure
Paste the link to picture in the entry below:
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Does this game get good?
View Single Post
Join Date: Mar 2009
Location: Kearney, NE
Posts: 346
Gamertag: zhoban
View My Profile
Does this game get good?
So far, I haven't found an ounce of good yet and I'm at the end of the Radio Station where I am getting ready for a escape that is very reminiscent of Silent Hill: Shattered Memories and I have to deal with a glitch where I need to go back into the Radio Station to get the Diluent and there is a open door yet there is also a closed door so I have to close the open door then open the closed door. And even aside from that, the game is so bogged down by terrible puzzles that require almost little to no thought, terrible chase scenes that are more frustrating than scary, poor enemy design, choices thrown into the game that don't even matter, terrible framerate and just any other problems that would make a game seem bad.
That being said, is there some point (hopefully soon) where I start thinking it is good? Hopefully this game doesn't do the same exact thing as Silent Hill: Origins, Silent Hill: Homecoming and Silent Hill: Shattered Memories did by randomly throwing in a Silent Hill 2 plot twist.
GT - zhoban. If you add me, send a message stating why otherwise I will just ignore it.
"I was weak, that's why I needed you. I needed someone to punish me for my sins. But that's all over now, I know the truth. Now it's time to end this." - James Sunderland (Silent Hill 2)
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text:
A guy stopped by yesterday that used to shoot long range match in the military and we got to talking about it.
We were talking about estimating the wind out to 1000yds. I told him of a guy I read that claims to be able to estimate the wind to 500yds and be withing 1 mph of correct. Well he said that's probally not true and even if it was, 1 mph isn't enough to make much difference. I asked about using grass to estimate it as that sounds like so much BS to me. And appearently it is. Sometime watch the grass, different stems blow in different dirrections and heavier grass doesn't bend as much. Forgot, he said to focus half way to the target for the reading.
Then he told me he could guess wind fairly close but only on fairly warm days. Your gonna love it. He uses high power binoculars or better a spotting scope and reads the heat waves! Yeep, that's what he said. That annoying garbage moves around with the wind. It'll tell you left to right and suggest velocity. Seem's that wind coming from say, 1:30, 4:30, 7:30 and 9:30, the effect is lower side deflection. That makes sence to me.
C.G., Rick, you guy's shoot long range. How accurate is this? Makes perfect sence to me but I'm in grade school.


text:
Becoming an All-American running back means you're newsworthy, even if reports are vague and lack details.
So we have reports that Arizona running back Ka'Deem Carey had a protection order issued against him stemming from an incident before Christmas,
Carey was issued the protection order after allegedly being involved in an incident Dec. 23. According to local reports, Carey has not been arrested for this or any other incident.
Then there's this from the Tucson Citizen:
KVOA also reported that Carey filed a harassment injunction that same day against Dana Rambow, the mother of his former girlfriend, Missy Rambow. On-line records confirm that filing, as well as an order of protection against Missy Rambow. Which filings came first on Dec. 26 is not clear.
The hearings on the harassment injunction and the protection order against Missy Rambow were scheduled for Monday morning.
It would appear that we have a he-said, she-said conflict, though the courts and not the police are where this is being battled out.
Arizona released statements from both coach Rich Rodriguez and athletic director Greg Byrne:
Rich Rodriguez statement regarding Ka'Deem Carey:
"I've spoken with Ka'Deem and am aware of the case. We take these matters very seriously and will support the authorities however we can. Once more specific information is available, we will act accordingly."
Greg Byrne statement regarding Ka'Deem Carey:
"The university and department of athletics are fully aware of the situation. This is now a matter for the local authorities and we will fully cooperate and assist them as needed. At this point we will have no further comment."
The question now is whether this is just a tempest of court filings due to emotions, or there will be a second chapter to this as details become available.


text:
Hi Frances,
Where in Florida are you moving? That state has zones from 8b to 10b and a
bit of 11, all lousy to grow hostas in. There may be enough chilling in very
northern Florida and the pan handle to allow hosta cultivation and a few
folks grow them there, but they are not successful plants further south.
They don't get enough chilling to survive long periods. You can grow them,
of course, for a short time (maybe 4-5 years) until they had enough, and
then replace them. Try the species and varieties that grow in southern Japan
and China. H. plantaginea and hybrids and H. kikutii, George
W. George Schmid
Hosta Hill - Tucker Georgia USA
Zone 7a - 1188 feet AMSL
84-12'-30" West_33-51' North
Outgoing e-mail virus checked by NAV
----- Original Message -----
From: "Frances" <firstname.lastname@example.com>
To: <email@example.com>
Sent: Friday, November 21, 2003 6:03 PM
Subject: Hosta in Florida
> I am in the process of moving to Florida and have many questions about
> hosta here. I have many in Zone 5 and would like to know if I can move
> of the special ones to Florida.
> I also have seeds which I would like to plant and am interested in Clyde's
> question about planting them outdoors in Florida.
> Thank you for any information you may provide.
> Frances
> ----- Original Message -----
> From: <email@example.com>
> To: <firstname.lastname@example.com>
> Sent: Friday, November 21, 2003 11:43 AM
> Subject: Planting Hosta Seeds Outdoors
> > Hi All,
> > I harvested some seeds from some streaked hostas('William Lachman, et
> > and planned to plant them in the under lights mode indoors but I am too
> lazy and
> > have tried doing that before with no luck;so, I'd like to plant these in
> > bed where I grew Vegetables and cutting flowers this season.
> > Anyone have any advice, such as depth, fertilising, mulching, watering,
> etc.
> > ?
> > Would very much appreciate any tips.
> >
> > Tak skal de har,
> >
> > Clyde C.
> >
> >
> >
> > Kleid Krokodil
> >
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November 2016
Food Vision USA
The Food Vision USA, the leadership forum for the nutrition industry, returns to Chicago! The third event in our annual Food Vision series of leadership forums will focus exclusively on the dynamics of the world's biggest food market and the energy and creativity of the manufacturers operating within it.
May 2016
IPA WC & Probiota Americas
Probiota Americas teams up with the IPA World Congress. Join us in Chicago at the end of May when we bring together eminent scientists and business leaders from the pre & probiotic focused nutrition and beverage industries of North and South America.
April 2016
Food Vision Asia
In April 2016, Singapore will host the first ever Food Vision Asia event, a forum that brings together senior figures in food R&D, marketing and business strategy from Asian food and nutrition businesses and from non-Asian companies eager to leverage opportunities in this expanding market.
March 2016
Food Vision 2016
Food Vision is an all inclusive, three day event with a format designed to facilitate knowledge transfer; develop commercial opportunities, and grow business relationships for leaders in the international nutrition and food & drink industries.


text:
PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53
- Xin You1,
- David L Boyle1,
- Deepa Hammaker1 and
- Gary S Firestein1Email author
DOI: 10.1186/ar2052
© You et al; licensee BioMed Central Ltd. 2006
Received: 05 July 2006
Accepted: 02 October 2006
Published: 02 October 2006
PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is deficient. To evaluate this issue, studies were performed to determine whether p53 is required for PUMA-mediated apoptosis in fibroblast-like synoviocytes (FLS). p53 protein was depleted or inhibited in human FLS by using p53 siRNA or a dominant-negative p53 protein. Wild-type and p53-/- murine FLS were also examined to evaluate whether p53 is required. p53-deficient or control FLS were transfected with PUMA cDNA or empty vector. p53 and p21 expression were then determined by Western blot analysis. Apoptosis was assayed by ELISA to measure histone release and caspase-3 activation, or by trypan blue dye exclusion to measure cell viability. Initial studies showed that p53 siRNA decreased p53 expression by more than 98% in human FLS. Loss of p53 increased the growth rate of cells and suppressed p21 expression. However, PUMA still induced apoptosis in control and p53-deficient FLS after PUMA cDNA transfection. Similar results were observed in p53-/- murine FLS or in human FLS transfected with a dominant-negative mutant p53 gene. These data suggest that PUMA-induced apoptosis in FLS does not require p53. Therefore, approaches to gene therapy that involve increasing PUMA expression could be an effective inducer of synoviocyte cell death in rheumatoid arthritis regardless of the p53 status in the synovium.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and invasion into cartilage and bone. Inadequate apoptosis of fibroblast-like synoviocytes (FLS) could contribute to this process by increasing the accumulation of cells in the intimal lining [1]. As a result of the aggressive nature of rheumatoid synovium and the relatively low level of apoptosis, interventions designed to increase programmed cell death of synoviocytes have been considered in treating RA. Several genes have been evaluated as potential gene therapy targets, including Fas [2], TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) [3], p53 [4], and PUMA (p53 up-regulated modulator of apoptosis) [5]. The latter is an especially interesting target because it rapidly induces apoptosis in cultured synoviocytes [5]. PUMA is a Bcl-2 homology 3 (BH3)-only pro-apoptotic Bcl-2 family member recently identified as a principal mediator of p53-dependent apoptosis [6]. The in vivo effects on apoptosis observed in PUMA-/- mice are similar to those in p53-/- animals, suggesting that PUMA can serve as an effector of p53 function [7, 8]. However, our previous studies showed that p53 is only a weak inducer of PUMA in FLS, which could account for the variable pro-apoptotic effect of p53 in this cell lineage, with no significant apoptosis induced by p53 overexpression in some studies [9, 10].
The mechanism of PUMA-mediated apoptosis has been extensively evaluated. PUMA expression leads to apoptosis by displacing p53 from Bcl-XL and allowing p53 to increase mitochondrial permeability [6]. The need for functional p53 raises significant concerns about the utility of PUMA as a therapeutic target in RA because deficient p53 expression or function in the rheumatoid synovial intimal lining has been described [11–14]. To address this issue, we determined whether PUMA requires functional p53 in cultured FLS. These studies show that PUMA-induced apoptosis can occur despite defects in the p53 pathway.
Materials and methods
Human and murine cultured fibroblast-like synoviocytes
Synovial tissues were obtained from patients with rheumatoid arthritis and osteoarthritis at joint replacement surgery. The diagnosis of RA conformed to the American College of Rheumatology 1987 revised criteria [15]. The protocol was approved by the University of California at San Diego Human Subjects Research Protection Program. FLS were isolated from individual tissues with 1 mg/ml collagenase and cultured in DMEM supplemented with 10% fetal calf serum, penicillin, streptomycin, and L-glutamine as described previously. Cell lines were used from the third to ninth passage, when they are a homogeneous population of fibroblast-like cells [16]. Although the origin of these cells cannot be certain, they probably derive from the intimal lining, on the basis of vascular cell adhesion molecule (VCAM)-1 and CD55 expression. In addition to RA FLS, we also examined FLS derived from osteoarthritis FLS in most experiments. No differences were observed between RA and osteoarthritis FLS in these assays. p53+/+ and p53-/- murine synoviocytes were obtained as described previously from DBA/1J wild-type mice (Jackson Laboratory, Bar Harbor, ME, USA) and DBA/1J p53-/- mice [17].
Affinity-purified rabbit polyclonal anti-p53 (for immunohistochemistry), mouse monoclonal anti-p53 (for Western blotting), and rabbit polyclonal antibodies against p21 and hemagglutinin (HA) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Anti-mouse and anti-rabbit IgG secondary antibodies were purchased from Cell Signaling Technology, Inc. (Beverly, MA, USA). Rabbit anti-PUMA polyclonal antibody was purchased from ProSci, Inc. (Poway, CA, USA).
Cell transfections
Scrambled RNA and p53 siRNA were purchased from Dharmacon Research, Inc. (Lafayette, CO, USA). Plasmids encoding HA-tagged full-length PUMA (HA-PUMA) and PUMA with a deletion of the BH3 domain (HA-PUMA-dBH3) were kindly provided by Dr B Vogelstein (Johns Hopkins Oncology Center, Baltimore, MD, USA) [5]. R213* encoding mutant p53 was isolated from a patient with RA and has previously been characterized as dominant-negative [14]. Bax-luc (BF72-2 PGL3) is a reporter construct containing the p53-responsive promoter for bax with the luciferase cDNA [14]. The control construct contains the β-Gal cDNA and the cytomegalovirus (CMV) promoter in pCI. Cells were transfected with the use of the Amaxa Human Dermal Fibroblast Nucleofactor kit (NHDF-adult) with program U-23 for human FLS. Murine FLS were transfected with the use of the Mouse Embryonic Fibroblasts kit (MEF1) with program T-20. Cells (2 × 105 to 106) were transfected with siRNAs, cDNAs, or control plasmids in each reaction.
Western blot analysis
Cultured FLS were washed with phosphate-buffered saline, and protein was extracted with lysis buffer (50 mM HEPES pH 8.0, 150 mM NaCl, 1% Triton X-100, 10% glycerol, 1 mM MgCl2, 1.5 mM EDTA, 20 mM β-glycerophosphate, 50 mM NaF, 1 mM Na3VO4, 10 μg/ml aprotonin, 1 μM pepstatin A, 1 mM phenylmethylsulphonyl fluoride). The protein concentrations were determined with the DC protein assay kit (Bio-Rad, Hercules, CA, USA). Whole cell lysates containing 50 μg of protein were fractionated by 12% SDS-PAGE and transferred to a nitrocellulose membrane. The membrane was blocked with Tris-buffered saline plus 0.1% Tween 20 (TBST) containing 5% non-fat milk for 1 hour at room temperature followed by incubation overnight with the appropriate antibody at 4°C. The membrane was washed three times and incubated with horseradish peroxidase-conjugated secondary antibody for 1 hour. Immunoreactive protein was detected by chemiluminescence with Kodak X-AR film (Eastman Kodak, Rochester, NY, USA).
siRNA-transfected cells for immunostaining were cultured in four-well chamber slides at 4.0 × 104 cells per well. They were then fixed with methanol, permeabilized with 0.05% Triton X-100 and blocked with 10% human serum. The fixed cells were incubated overnight with anti-p53 antibody or matched control antibody at 4°C. Endogenous peroxidase was then depleted with 0.1% H2O2 and 0.1% NaN3. The cells were then washed and stained with biotinylated secondary antibody anti-mouse or anti-rabbit IgG and Vectastain ABC and developed with diaminobenzidine (Vector, Burlingame, CA, USA).
Cell viability and apoptosis assays
FLS were harvested and suspended in 0.2% trypan blue and counted with a hemocytometer. Cells that excluded dye were considered viable. Apoptosis was determined with a Cell Death Detection ELISAPLUS kit (Roche Applied Science, Mannheim, Germany). FLS (4 × 103) were seeded into each well of a 96-well plate after transfection. Nine hours later, samples were collected and ELISA was performed in accordance with the manufacturer's instructions. Results are presented as the fold induction compared with control. To confirm the role of apoptosis, caspase-3 activation was also determined in transfected cells with the use of the human active caspase-3 ELISA (R&D Systems, Minneapolis, MN, USA). PUMA or PUMA-dBH3 plasmids were transduced into p53 siRNA-transfected or scrambled siRNA-transfected cells. The cells were then cultured at 4.5 × 105 cells per well in six-well plates. Eight hours later, the cells were lysed and assayed as described by the manufacturer.
Cell proliferation assay
Alamar Blue assays incorporate a fluorimetric/colorimetric growth indicator based on the detection of metabolic activity. FLS (3 × 103) were plated into 96-well plate after siRNA transfection. At various time points, medium was replaced by DMEM without phenol red supplemented with 10% Alamar Blue. After incubation for 4 hours at 37°C, fluorescence was measured with a microplate reader at an excitation wavelength of 530 nm and an emission wavelength of 590 nm. The number of cells is expressed as relative fluorescence units.
Statistical analysis
Data are expressed as means ± SEM. Statistics were performed with Student's t test, one-way analysis of variance and repeated-measures analysis of variance. A comparison was considered significant at p < 0.05.
Use of siRNA to knockdown p53 protein in fibroblast-like synoviocytes
Functional effects of p53 deficiency
p53-independent apoptosis induced by PUMA
p53-independent apoptosis induced by PUMA in murine fibroblast-like synoviocytes
PUMA-mediated apoptosis in the presence of mutant p53
Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal lining [2, 4]. This region is populated by macrophage-like and fibroblast-like synoviocytes and is a primary source of cytokines and enzymes that degrade the extracellular matrix. The accumulation of cells in the lining can be due to ingress of cells from the blood, local proliferation, or insufficient deletion through apoptosis. The latter is especially intriguing in view of the observation that many pro-apoptotic genes are either defective or minimally expressed in RA, including p53, sentrin [19], and PTEN (phosphatase and tensin homologue deleted on chromosome 10 [20].
p53 is an interesting potential therapeutic gene because it can induce apoptosis in many cell types. Although controversial, defects in p53 structure and function in RA have been described, suggesting that forced expression of the tumor suppressor protein could be beneficial [11, 12, 21, 22]. However, enhancing p53 gene expression in synovium with an adenoviral construct had only modest efficacy in a rabbit model of arthritis [4], and a similar approach was not effective in the rat adjuvant arthritis model (P.P. Tak, D.L. Boyle, G.S. Firestein, unpublished data). One potential explanation for the limited effect is that p53 does not readily induce apoptosis in synoviocytes, probably because PUMA expression is not increased [5]. In contrast, directly transducing cells with PUMA leads to rapid synoviocyte death in vitro.
One issue that could potentially interfere with the efficacy of PUMA gene therapy in RA is that this protein usually requires the p53 to induce apoptosis [6]. Elegant studies have demonstrated that the mechanism of PUMA action is through the release of p53 from inhibitory interactions with Bcl-XL in the cytoplasm [6]. Unbound p53 protein can then directly activate Bax. If p53 is defective or deficient, the benefit of forced PUMA expression would potentially be lost.
PUMA accounts for many of the apoptotic activities attributed to p53 [9, 10], although it can serve as a mediator of some apoptotic pathways that do are not initiated by p53 induction, including glucocorticoids and serum deprivation [7, 23]. PUMA-mediated apoptosis can also bypass p53 in unusual situations, especially in tumor cells. For instance, p53 expression does not require PUMA in melanoma and glioma cell lines [24, 25] or human leukemia cells [26]. Hence, the utility of PUMA as an apoptosis-inducing protein and its relationship to p53 depends on the cell lineage, the status of p53 (deficiency versus mutation), and the type of stimulus. Therefore p53 has a dual role related to PUMA gene expression and function. In most cell types, p53 expression leads to increased PUMA gene expression and subsequent PUMA-mediated apoptosis requires functional p53. It is of interest that neither of these relationships is effective in cultured FLS. This cell lineage can also be distinguished from other cells in that p53 is expressed constitutively [18] even though the short half-life of wild-type p53 protein generally limits detection in non-cycling cells.
These highly variable data imply that tissue-specific cells should be studied to determine the potential applicability of PUMA gene therapy to RA. Our experiments using siRNA to decrease p53 expression show that FLS are very sensitive to PUMA-induced death and that p53 expression has no influence on this effect. Because siRNA does not completely deplete p53 levels, we confirmed these results in p53-/- murine FLS. Finally, we showed that PUMA could function even in cells transfected with a known dominant-negative p53 mutant. These data demonstrate that PUMA-induced apoptosis in synoviocytes does not require p53 and that PUMA gene transfer could be effective regardless of the p53 status of the synovium.
These data support the potential use of PUMA as a local gene therapy approach to RA. By circumventing possible abnormalities in p53 and inducing extensive apoptosis of synoviocytes, intra-articular gene transfer could decrease the hyperplasia of the synovial intimal lining. Although not feasible for systemic administration, local therapy could debulk the synovium in RA and serve as an alternative to synovectomy or intra-articular corticosteroids.
PUMA efficiently induced apoptosis in control and p53 deficient human FLS after PUMA overexpression. Similar results were observed in p53-/- murine FLS and in human FLS transfected with the R123* mutant p53 gene. PUMA-induced apoptosis is therefore independent of p53 in FLS. These data suggest that PUMA gene therapy could be effective in RA regardless of the p53 status of the synovium.
= Bcl-2 homology 3
= Dulbecco's modified Eagle's medium
= enzyme-linked immunosorbent assay
= fibroblast-like synoviocytes
= hemagglutinin
= p53-upregulated modulator of apoptosis
= rheumatoid arthritis
- siRNA:
= small interfering RNA.
This work was supported by grant R01 AR45347 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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