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Canadian Defense Minister in Hot Water as Canada Caps F-35 Funding
Shane McGlaun
April 9, 2012 9:59 AM
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MacKay sits in F-35 cockpit
(Source: The Star)
Canada still unsure of F-35 program
The reaction of some Canadian citizens and lawmakers has been mirroring the reaction we've seen in United States over the F-35 program. There's a lot of uproar over continually rising costs of the program and in Canada. There have also been allegations that some government officials knew the cost the program would be significantly more than originally promised, yet said nothing.
Canadian Defense Minister Peter MacKay has recently admitted that he knew the F-35 fighter program could cost as much as $25 billion. That price is billions of dollars more than the Canadian officials have publicly acknowledged. However, MacKay maintains there was never an effort to mislead Canadians on how much the project would cost.
MacKay maintains that the $10 billion difference between what the F-35 program has been officially acknowledged to cost and what the program could really cost is an accounting difference. The cost for Canada to purchase 65 F-35 fighters was originally said to be $15 billion. Some of MacKay's opposition in the Canadian government have gone so far as to request his resignation over the price row.
According to MacKay, the $10 billion difference is money the Canadian government already pays for things like fuel, salaries, and maintenance of the fleet of CF-18 fighters the F-35 replace.
"Yes, and it was explained to me just that way," MacKay said.
"The additional $10 billion was money that you could describe as sunk costs. What we're paying our personnel and the fuel that is currently being expended in CF-18s, jet fuel, maintenance costs — what we're currently spending, so not part of a new acquisition," MacKay said.
He continues saying that similar accounting methods are used in acquisition of other military hardware.
"I don't agree that there was a manipulation of information," MacKay continued. "Of course ministers are responsible for what takes place in their department. I've acted in good faith, always with an eye to providing the men and women in uniform with the best equipment that we can possibly get."
While MacKay fights allegations that he misled Canadian citizens on the price of the F-35, other officials in the Canadian government still maintain that additional oversight of acquisition will be performed. Conservative party Prime Minister Stephen Harper noted last week that Canada has signed no contract to purchase the F-35. That statement hints that Canada could reduce the number of F-35 that purchases. Cuts in proposed
have been talked about in the past.
"The auditor-general has identified a need for greater independence and supervision over some of the activities of the Department of National Defence," Harper said. "The government will put that supervision in place before we proceed."
The amount of funds assigned to purchase 65 F-35 aircraft has also been capped. The cap placed on the purchase is C$9 billion, which works out to about $8.9 billion in the US. That funding includes money spent for the acquisition of associated weapons, infrastructure, initial spares, and training simulators.
"Funding will remain frozen and Canada will not purchase new aircraft until further
due diligence
, oversight and transparency is applied to the process of replacing the Canadian Forces' aging CF-18 fleet," Public Works Minister Rona Ambrose said in a statement.
"If a man really wants to make a million dollars, the best way would be to start his own religion." -- Scientology founder L. Ron. Hubbard
Related Articles
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April 4, 2012, 11:04 AM
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Hotel New Tochigiya, Tokyo
- Free WiFi
Main amenities
- 39 guestrooms
- Tour/ticket assistance
What's around
- In Asakusa
- Sensoji Temple (0.3 mi / 0.5 km)
- Asakusa Shrine (0.3 mi / 0.5 km)
- Tokyo Sky Tree (1.2 mi / 1.9 km)
- Tokyo National Science Museum (1.2 mi / 1.9 km)
- Tokyo National Museum (1.2 mi / 1.9 km)
The hotel was cery clean. The room was comfortable. Location was PERFECT!
Didn't like it. The floor I was on stunk. The bathroom stunk. At least the capsule didn't…
Hotel New Tochigiya, Tokyofrom €16
- Capsule Room Male Only, Non Smoking Floor (Lower stage)
- Capsule Room Male Only, Non Smoking Floor (Upper stage)
- Single Room Without Bath
- Private Japanese Twin Room, Without Bath, Smoking
- Double Room, Private Bathroom, Annex Building
- 2 Capsule Room Male Only, Smoking Floor, Upper or Lower capsule
- 2 Capsule Room Male Only, Non Smoking Floor, (Upper or Lower capsule)
- Twin Room, 2 Single Beds, Private Bathroom, Annex Building
- Twin Room, Private Bathroom
- Twin Room, Private Bathroom, Annex Building
- Japanese Single Without Bath Male Only
- Double Room, Japanese Futon, Private Bathroom
- Single Room, Japanese Futon, Private Bathroom
- Single Room, Japanese Futon, Shared Bathroom
- Capsule Room Male Only, Smoking Floor (Lower stage)
- Japanese Single Without Bath Female Only
- Capsule Room Male Only, Smoking Floor (Upper stage)
More great choices
At a glance
Key facts
Hotel size
- This hotel has 39 rooms
- Check-in time starts at 4 PM
- Check-out time is 10 AM
Required at check in
- Cash deposit required
- Government-issued photo ID required
Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi in rooms
Nearby One Star Tokyo hotels
In the hotel
- Tours/ticket assistance
In the room
- Individually furnished
- Free WiFi
Top Tokyo hotels
Recently reviewed hotels in Tokyo
- Remm AkihabaraFrom
"Stayed for a night in December 17. A conveniently located hotel which is less than a 5 min walk from the Akihabara metro station. The check in was efficient and the staff (fairly…"Dec 26, 2016
- APA Hotel Ueno-EkimaeFrom
"as with all Tokyo hotels it's small"Dec 22, 2016
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"Great location for access to the nightlife. Breakfast was average. No room service for coffees. Staff friendly enough and do their best to communicate with varying levels of…"Nov 14, 2016
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Nearby hotels
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Hotel New Tochigiya, Tokyo's small print
Also known as
- Hotel New Tochigiya
- Hotel New Tochigiya Tokyo
- Hotel Tochigiya
- New Tochigiya
- New Tochigiya Tokyo
- Tochigiya Hotel
- Hotel New Tochigiya Tokyo, Japan
The Japanese Ministry of Health, Labour, and Welfare requires all international visitors to submit their passport number and nationality when registering at any lodging facility (inns, hotels, motels, etc. ). Additionally, lodging proprietors are required to photocopy passports for all registering guests and keep the photocopy on file.
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Good 3.2 /5 from 222 reviews
Efficient reception, but 3pm checkin too late, and 10am checkout too early for people on vacation! 100 yen per hour for TV is funny. Sauna and bath were good. Pod clean, power adapter available at reception. Microwave available.
Needed a cheap hotel for Tokyo and this was one of the cheapest outside of a capsule hotel. Was in a side alley off of a shopping arcade. The downstairs had an impressive library of Manga (including some English translated ones!). The room was small, but comfortable. Small bathroom left a bit to be desired, but seriously, you CANNOT beat the price here. Right by Senso-ji temple and some great spots around Asakusa.
reasonable prize for budget stay and very near proximity to attractions. near to subway, shopping nakamise street, and even halal restaurants are also nearby. the only negativity was WiFi connection was very slow.
It's dusty, dirty, loud n smelly (cigarette)
We spent here for 4 nights. overall the hotel was comfy enough to take a rest ,thought the room was very small. Comparing to its cost, it was worth staying. However, it was quite far from the station.
Is the description of this hotel not correct? Tell us

subset: commoncrawl


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Recap - Arizona Defeats Southern 69-43
Arizona cruised to victory on Thursday, running Southern out of the gym and running up a 69-43 score at McKale Center.
Arizona got 21 points from Aaron Gordon and another 17 points from Nick Johnson. T.J. McConnell contributed 6 assists, while Brandon Ashley cleaned the glass with 10 rebounds.
Southern got 11 points from Malcolm Miller in a losing cause and another 11 points from Calvin Godfrey. Trelun Banks contributed 3 assists for them, while Malcolm Miller had 6 rebounds.
Arizona hit the break leading 34-19 before taking care of business in the second half.
Arizona had a 39-33 advantage in the rebounding department as they won the battle in the paint.


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Eva Wedding Guide
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If you're a fan of paranormal romance/suspense and you haven't checked out Lynn Viehl's Darkyn series, you are missing out on some of the most original and well-told stories in the genre. Her seven books — If Angels Burn, Private Demon, Dark Need, Night Lost, Evermore, Twilight Fall and the newly released Stay the Night – have spun a new and very interesting take on the vampire legend that blends historical figures and events, modern medical research, and conspiracy theories with a whole bag full of plot twists and turns.
Stay the Night has only been on book shelves for a few weeks, and already two things are crystal clear. The first is that Viehl is tying up a lot of the questions and storylines presented in previous books – for what purpose, I can only speculate. Second, she's simply written the best book I've seen from her so far.
The basic premise of the Darkyn mythos is that during the Crusades, the Templar knights who went to the Holy Land to fight for king and country picked up a "curse." Upon their return home, a plague swept through Europe, claiming thousands of lives, including many of the medieval warrior priests and their families. Because of the "curse," those who went to the Holy Land and those closest to them rose from the grave three days after death. They were in most senses vampires, needing to feed on blood and being nearly indestructible, not to mention seemingly immortal.
Considering the time period in which this took place, it's logical that those who witnessed this phenomenon instantly condemned the newly risen Darkyn as agents of the devil. Soon the Catholic church took up the torch of the masses and formed a secret society called The Brethren. This group has spent centuries breeding fanatics whose sole purpose is to torture and murder Darkyn and those who are allied with them. They don't care that the Darkyn have long stopped killing humans for food and can no longer change anyone else to grow their ranks. Though the Brethren have long since been banished by the church, they still pose as Catholic priests and monks as a cover for their agenda and pursuit of Darkyn prisoners.
Fast forward to the 21st-century Chicago and the offices of Dr. Alexandra Keller. She's the fastest plastic surgeon in the world. The series' first book, If Angels Burn, establishes how she's the first human to make the change to Darkyn in a millennium and sets up her romantic relationship with Michael Cyprien, the Darkyn ruler of America. She becomes the only modern doctor the Darkyn have ever known and figures out that the "curse" is actually some kind of pathogen that infected those who returned from the Crusades and was passed to others. The pathogen is the cause of the vampirism, and Alex is determined to find a cure.
Throughout the rest of the books, both Alex and Michael play a key role in advancing the ongoing story arc, which reveals the crumbling leadership of the Darkyn king, Richard (due to a strange physical transformation from being forced to drink cat blood for years) and the escalating war between the Darkyn and Brethren. Along the way, each book centers on a new couple and almost always a new human who is turned, which also serves to advance the overall picture Viehl is trying paint.
In Evermore, the fifth book of the series, some familiar characters are introduced: Robin of Locksley, Guy of Guisborne/Lord Nottingham, Will Scarlett, and Lady Marian. I was very skeptical of this addition because of its potential to come off as being cheesy. However, Viehl gave a new spin to the Robin Hood legend that was refreshing and oddly believable. All of the aforementioned characters had turned Darkyn, with the exception of Marian. Robin has become suzerain (local Darkyn ruler) of Atlanta and is the bitter enemy of Nottingham. Both men blame each other for Marian's death and try to kill each other throughout the course of the book, among other storylines.
Stay the Night continues this story by centering on Robin and his quest to acquire an ancient tome, The Maiden's Book of Hours, and establishes him as the world's greatest thief. True, he's stealing mostly artifacts that belonged to Darkyn throughout the centuries, but the humans don't know that and his notoriety has captured the attention of a certain female FBI agent who is looking to clear her partner's name. Chris is distraught that her partner killed himself in Atlanta, where the book is supposed to be, and needs to prove that he wasn't suicidal and was in fact trying to catch this thief and hand over the book he sought to the authorities.
While there trying to trap the thief, she falls for a mysterious stranger she meets in a club. The man turns out to be Robin, a consummate ladies man who is affronted by her abrupt departure and determined to recapture her attention. Then he finds out who she really is and what she's after, and has to decide exactly how to play her in order to get what he wants.
Circumstances change as a new foe enters the picture and blackmails Robin into finding the The Maiden's Book of Hours, which was stolen by Nottingham during Chris' sting. Robin kidnaps Chris and takes her to Italy in pursuit of the book, all the while fanning the fire developing between them. More turns and twists unfold, including betrayals of all sorts, a short-lived alliance between Nottingham and Robin, a plot to destroy the world and a miracle that ends Alex's quest to find a cure for vampirism.
While all of this is going on, Alex and Michael attend a summit of the world's Darkyn leaders. The main decision to be made: should the Darkyn declare active war on the Brethren? The summit's outcome and a discovery Alex reveals to the whole group affectively changes the course of the whole series, and quite possibly makes this book the last of the Darkyn stories.
At the end of the book is an excerpt from a new series Viehl will debut in November called Shadowlight, which will be the first in the Kyndred series, an apparent sequel to the Darkyn series. I don't think that this is the end of the Darkyn series, though, because Stay the Night sets up at least one final story that needs to be told. I hope that Viehl does at least wrap up these loose ends, if not in one last Darkyn book, then in Shadowlight.
Viehl's storytelling style is really enjoyable to read. She tells all of her stories in dribs and drabs through various perspectives that keep the reader turning every page to see what happens next. Having read all of the Darkyn books, I can clearly see how her style and storytelling has evolved over the years. Each book is more engaging and intricate than the last, making Stay the Night by far the most interesting and surprising story of the whole series.
My only complaint is the cover art. All of the other books have used jewel-tone colors that add a vibrant compliment to the rich storytelling that goes on within the pages. Stay the Night has wash of white and pearl blended with purples. While this certainly makes the book stand out from the others, I think it does not reflect the story inside.
For paranormal and vamp fans of all kinds, this whole series is a must-read. Lots of action, history, sex, intrigue and plot twists make for very satisfying reading.Powered by Sidelines


text:
Carlsbad (CA) – Jeff Hawkins today announced a new product which he believes completes the vision of the company he founded: A sub-notebook-sized companion device that extends smartphones with a larger keyboard and a larger screen.
Hawkins did not reveal many technical details about the device, besides highlighting that the Foleo runs about 5 hours on one battery charge, that it comes with Wi-Fi and Bluetooth connectivity, that the color screen runs un a 1024 x 600 resolution and that the companion is designed as a "solid state" device, meaning that it does not have a hard drive. Instead, it uses a compact flash memory card as its primary memory, which can be expanded with SD cards. The operating system is based on Linux.
The main purpose of the device is to synchronize email and contacts with a Palm OS-based or Windows-Mobile-based smartphone. Palm said that while every Treo is supported, the company believes that any other Windows Mobile phone should work with Foleo as well. The firm is working to add support for Blackberrys and Symbian phones and would be interested in supporting the iPhone as well, if Apple is willing to open the phone up, Hawkins said.
The software suite is rather limited at this time and includes email, an attachment viewer (supports, for example, office, PDF and image files) and a web browser. However, not all web content is supported, as the hardware will not be powerful enough to playback videos on YouTube initially, according to Hawkins.
So, in a way, Foleo, isn't quite a notebook and it isn't quite a smartphone, which may raise questions why and which users should buy it. Hawkins mentioned that the device is not designed to replace a notebook for once, it will not replace a smartphone and it certainly cannot replace the iPod many travelers are bringing along on their business trips. While Foleo has some advantages, such as instant on/off capability, it is another device you potentially would have to bring along on your plane trip.
Foleo will launch later this year for about $500, including a $100 introductory rebate.


text:
Right ventricular dysfunction developing late after congenital cardiac surgery is one of the most common causes of heart failure in adults with congenital heart disease. In tetra logy of Fallot (ToF), the most common cyanotic heart defect, initial repair in infancy involves an incision and patch in the RV outflow, including the pulmonary valve, which often results in late development of severe RV dilatation and dysfunction due to chronic pulmonary regurgitation and RV scarring/patch dilatation. Current surgical management of late RV dysfunction, consisting of pulmonary valve insertion and reduction of the RV outflow patch, reduces RV volume but does not result in a predictable improvement in RV function. A more radical procedure, which includes extensive removal of scar and outflow patch, is being evaluated in an NHLBI sponsored randomized prospective trial. However, there is no currently available method for predicting outcome after either procedure or what the optimal procedure is for a given pt., i.e. no clinically useful tools for determining patient-specific therapy. In this project, we propose to develop a computational modeling approach to determine the efficacy and suitability of the various reconstructive options to treat failing RV in ToF pts. We will use non-invasive cardiac magnetic resonance imaging (CMR) to provide patient-specific RV/LV morphology, deformation, and flow data for the construction and validation of computational models. 3D CMR-based RV/LV combination models will be constructed, which include fluid-structure interactions (RV/LV and RV patch), two-layer RV/LV structure, anisotropic material properties, fiber orientation, and active contraction to simulate blood flow, heart motion, and stress/strain distribution to evaluate the effect of different remodeling procedures on RV function, and to seek an optimal RV volume and patch design to improve post-operative RV function. Clinical imaging and hemodynamic data from an ongoing NHLBI-funded clinical trial will be used to build and validate the model. Our ultimate goal is to apply this methodology in patient- specific computer-aided cardiac surgery planning to reach optimal surgical procedure design and outcome in patients with RV dysfunction from congenital heart defects. A multidisciplinary group of experienced investigators in congenital cardiac surgery, cardiology and computational mathematics will conduct this project.
This project aims to use MRI images obtained from patients with repair tetralogy of Fallot that are being evaluated for surgery to develop computational models of right ventricular function. The ultimate goal is to develop models that will predict outcomes and optimize right ventricular function after surgery. The MRI's to be used for this study are clinically indicated studies as part of the care of these patients and are currently obtained under an approved protocol where Dr. Tal Geva is the principal investigator.
|Valente, Anne Marie; Gauvreau, Kimberlee; Assenza, Gabriele Egidy et al. (2014) Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort. Heart 100:247-53
|Geva, Tal (2014) Is MRI the preferred method for evaluating right ventricular size and function in patients with congenital heart disease?: MRI is the preferred method for evaluating right ventricular size and function in patients with congenital heart disease. Circ Cardiovasc Imaging 7:190-7
|Tang, Dalin; Yang, Chun; Geva, Tal et al. (2014) Right ventricular local longitudinal curvature as a marker and predictor for pulmonary valve replacement surgery outcome: an initial study based on preoperative and postoperative cardiac magnetic resonance data from patients with repaired tetralogy of Fal J Thorac Cardiovasc Surg 147:537-8
|Geva, Tal (2013) Indications for pulmonary valve replacement in repaired tetralogy of fallot: the quest continues. Circulation 128:1855-7
|Yang, Chun; Tang, Dalin; Geva, Tal et al. (2013) Using contracting band to improve right ventricle ejection fraction for patients with repaired tetralogy of Fallot: a modeling study using patient-specific CMR-based 2-layer anisotropic models of human right and left ventricles. J Thorac Cardiovasc Surg 145:285-93, 293.e1-2
|Yamauchi, Haruo; Feins, Eric N; Vasilyev, Nikolay V et al. (2013) Creation of nonischemic functional mitral regurgitation by annular dilatation and nonplanar modification in a chronic in vivo swine model. Circulation 128:S263-70
|Tang, Dalin; Yang, Chun; Geva, Tal et al. (2013) A Multiphysics Modeling Approach to Develop Right Ventricle Pulmonary Valve Replacement Surgical Procedures with a Contracting Band to Improve Ventricle Ejection Fraction. Comput Struct 122:78-87
|Yamauchi, Haruo; Vasilyev, Nikolay V; Marx, Gerald R et al. (2012) Right ventricular papillary muscle approximation as a novel technique of valve repair for functional tricuspid regurgitation in an ex vivo porcine model. J Thorac Cardiovasc Surg 144:235-42
|Tang, Dalin; Yang, Chun; Geva, Tal et al. (2011) Multi-Physics MRI-Based Two-Layer Fluid-Structure Interaction Anisotropic Models of Human Right and Left Ventricles with Different Patch Materials: Cardiac Function Assessment and Mechanical Stress Analysis. Comput Struct 89:1059-1068
|Geva, Tal (2011) Repaired tetralogy of Fallot: the roles of cardiovascular magnetic resonance in evaluating pathophysiology and for pulmonary valve replacement decision support. J Cardiovasc Magn Reson 13:9
Showing the most recent 10 out of 11 publications


text:
2011 Chevrolet Suburban 1500 Repair and Maintenance Costs
A guide to repairs, service, and maintenance costs for your 2011 Chevrolet Suburban 1500
Never overpay. Check prices with our estimator
Verified by mechanics, reported by drivers like you
Ask a mechanic in our community
2011 Chevrolet Suburban 1500 ProblemsPower Door Lock Actuators May Fail
The power door lock actuators may become slow to operate or stop working completely and require replacement.
The 4WD transfer case encoder motor position sensor or the selector switch may fail causing the service 4WD message to be displayed. Fault code(s) stored in the transfer case control module will be of assistance in determining the exact fault causing the message to be displayed.
The speedometer or other instrument panel gauge may begin to work erratically at times. Our technicians tell us that the instrument cluster must be sent to a repair facility to correct this fault. The warranty has been extended on some of these units to 7 years or 70,000 miles.
2011 Chevrolet Suburban 1500 QuestionsEngine light on (1 answer)
Driving early in am and it is cold(4degrees) . Engine light goes off and car goes into reduced power mode and runs at 30-40 mph. On star says something about fuel injectors. What could this be?
It feel like it's topped out
2011 Chevrolet Suburban 1500 RecallsPassenger Frontal Air Bag Inflator Ruptures On Deployment
The passenger frontal air bag inflator may rupture on deployment, causing metal fragments to come through the air bag and injure occupants. Dealers will replace the passenger frontal air bag inflator free of charge to resolve the concern.
The ignition switch actuator can bind causing the ignition switch to stick in the "start" position. If this were to occur the actuator can unexpectedly release, cause the ignition switch to snap back into the "Accessory" position. This would cause the engine to turn off with an associated loss of brake and steering power assist. If these conditions were to lead to a crash the airbags may not deploy as expected. Dealers will inspect and replace the ignition lock housing as necessary to correct this concern.
The intermediate steering shaft attaching bolts may not have been tightened to the proper specification. This could allow the steering shaft to separate. The driver could experience a loss of steering ability, increasing the risk of a crash. Dealers will inspect and ensure the intermediate steering shaft bolts are tightened to the proper specification. This recall is expected to begin on July 13, 2011. The General Motors recall number is 11191.


text:
The Horse Forum (http://www.horseforum.com/forumindex.php)
- Meet the Community (/meet-community/)
- - Another Canadian who is doing some Detective work! (http://www.horseforum.com/meet-community/another-canadian-who-doing-some-detective-65981/)
Another Canadian who is doing some Detective work!
Hi all!
Another Canadian over here! I live about 2 hours from Lake ontario and can't wait to get to know you all! :D
I'm in and out of both english and western right now. Though I'm primarily western right and focusing on turning my 4 year old morgan X Quarter horse mare into a trail machine!
a.k.a Athena the love of my life and my horsey soul mate!
As to the strange title of this thread I've come here orginally to do some saddle brand hunting. I picked up a saddle about a month ago and I'm on the hunt to find the back ground on it! Keep an eye on my other threads to learn more!
welcome! I have two horses, Murray and Archy.
Good luck with your searching. And your mare is BEAUTIFUL!
And thank you! Athena is my pride and joy! I've had her since she was about 14 months old :D
Welcome to the forums! Your mare is lovely and your pasture is really pretty!
Good luck in your search!
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This is the April 9, 2014 news archive. View today's Titans rumors and news.
Tennessee Titans
Tennessee Titans News and Rumors
Report: Titans work out O'Brien Schofield
profootballtalk.com Updated Apr 9, 2014
At the outset of free agency, it appeared outside linebacker O'Brien Schofield was on his way to signing a two-year, $8 million contract with the Giants. However, a knee issue caused the Giants to pass on finalizing the deal, leaving Schofield available…Share Tweet
Chris Johnson's FutureApr 9ESPN NFL Insider Ed Werder discusses the teams that are interested in signing RB Chris Johnson.
Roster Reset: AFC SouthApr 9Which team in the AFC South did the best for its squad during free agency? Our analysts break down some of the best signings, which include a wide receiver looking to rebound on a poor 2013 season.


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Abstinence from smoking produces aversive symptoms that prompt relapse, often within the first week following a quit attempt. Clarifying the neurobiological and behavioral underpinnings of these early abstinence symptoms is, therefore, critical to develop more efficacious treatments. The proposed Center for Interdisciplinary Research on Nicotine Addiction (CIRNA) extends nine years of research conducted in the Transdisciplinary Tobacco Use Research Center (TTURC) at UPENN. Spanning from preclinical to clinical studies, CIRNA includes a highly interactive set of projects and cores that seek to: (1) discover the cellular, molecular, neural, and behavioral basis of early nicotine abstinence effects that contribute to relapse;(2) identify brain and behavioral mechanisms through which efficacious therapies modulate these processes;and (3) validate novel medication screening approaches. Project 1 uses neurobiology and pharmacology to elucidate the molecular and behavioral basis of emotional and cognitive symptoms of nicotine abstinence and re-exposure in a mouse model. Project 2 uses electrophysiology and pharmacology to explore the effects of nicotine abstinence and re-exposure on sensory processing in key brain regions in mice. Project 3 uses human neuroimaging to examine the neural substrates of early abstinence symptoms and medication response. Project 4 extends this work by validating novel approaches to improve the sensitivity of early human medication screening paradigms for nicotine dependence. Shared resources, including an Administrative Core, a Data Management and Biostatistics Core, and a Biospecimen Core provide value-added, as well as support for a comprehensive data sharing plan. A Career Development Core promotes involvement of post-doctoral fellows and junior investigators in these projects, and supports pilot projects to facilitate career development. Thus, the CIRNA addresses the clinically important problem of nicotine dependence using innovative multidisciplinary approaches, with the ultimate goal of developing more efficacious medications for tobacco dependence and prevention of tobacco-related disease. The CIRNA is proposed to replace the TTURC, since this NIH initiative is ending.
The proposed Center will generate new knowledge of the biological and behavioral bases of early nicotine abstinence symptoms that contribute to smoking relapse, and will study how efficacious medications reverse these processes. This information will be valuable to develop more effective medications to treat nicotine dependence.
|Cole, Robert D; Poole, Rachel L; Guzman, Dawn M et al. (2015) Contributions of ?2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice. Psychopharmacology (Berl) 232:1207-17
|Jain, Raka; Jhanjee, Sonali; Jain, Veena et al. (2014) A double-blind placebo-controlled randomized trial of varenicline for smokeless tobacco dependence in India. Nicotine Tob Res 16:50-7
|Falcone, Mary; Wileyto, E Paul; Ruparel, Kosha et al. (2014) Age-related differences in working memory deficits during nicotine withdrawal. Addict Biol 19:907-17
|Turner, J R; Ray, R; Lee, B et al. (2014) Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence. Mol Psychiatry 19:801-10
|Ashare, Rebecca L; Falcone, Mary; Lerman, Caryn (2014) Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment. Neuropharmacology 76 Pt B:581-91
|Hussmann, G Patrick; DeDominicis, Kristen E; Turner, Jill R et al. (2014) Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. J Neurochem 129:721-31
|Yohn, Nicole L; Turner, Jill R; Blendy, Julie A (2014) Activation of ?4?2*/?6?2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors. J Pharmacol Exp Ther 349:348-54
|Ashare, Rebecca L; Schmidt, Heath D (2014) Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal. Expert Opin Drug Discov 9:579-94
|Goelz, Patricia M; Audrain-McGovern, Janet E; Hitsman, Brian et al. (2014) The association between changes in alternative reinforcers and short-term smoking cessation. Drug Alcohol Depend 138:67-74
|Poole, Rachel L; Connor, David A; Gould, Thomas J (2014) Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice. Behav Neurosci 128:588-93
Showing the most recent 10 out of 69 publications


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The Licensing and Compliance Lab interviews Michael Zahniser of Endless SkySubmitted by Rianne Schestowitz on Monday 29th of February 2016 09:46:33 PM Filed under
This is the latest installment of our Licensing and Compliance Lab's series on free software developers who choose GNU licenses for their works. In this edition, we conducted an email-based interview with Michael Zahniser of Endless Sky
Fedora project leader Matthew Miller reveals what's in store for Fedora in 2016Submitted by Roy Schestowitz on Saturday 27th of February 2016 08:13:19 PM Filed under
Fedora shook things up at the end of 2014, releasing Fedora 21 based on the "Fedora.next" initiative, which saw the project refocus itself into three distinct products for Workstation, Cloud, and Server. I recently spoke to Fedora project leader Matthew Miller to see how Fedora's been doing since then and what's in store for Fedora in 2016.
Openness and transparency are keys to success for Red Hat CEOSubmitted by Rianne Schestowitz on Tuesday 23rd of February 2016 07:06:27 PM Filed under
Jim Whitehurst, president and CEO of Raleigh, North Carolina-based Red Hat, helped turn the open source software solutions business into what Forbes called "one of the world's most innovative companies," in 2012, 2014 and 2015. His book The Open Organization: Igniting Passion and Performance was published last year. Whitehurst took over the top job at Red Hat in 2008. Prior to that, he spent six years at Delta Air Lines, where he worked his way up to the chief operating officer position. He played an instrumental role in the airline's financial turnaround. Before that, he worked with the Boston Consulting Group. A Columbus, Georgia native, Whitehurst earned a bachelor degree in economics and computer science from Rice University in 1989, and his master's in business administration from Harvard University in 1994. He lives in Durham with his wife and their two children, who are twins. He spoke with Craig Dowden.
Achieving Enterprise-Ready Container Tools With Wercker's Open Source CLISubmitted by Roy Schestowitz on Monday 22nd of February 2016 03:31:31 PM Filed under
Using the Wercker Command Line Interface (CLI), developers can spin up Docker containers on their desktop, automate their build and deploy processes and then deploy them to various cloud providers, like AWS, and scheduler and orchestration platforms, such as Mesosphere and Kubernetes.
The Wercker Command Line Interface is available as an open source project on GitHub and runs on both OSX and Linux machines.
More Torvalds TED Cov erageSubmitted by Roy Schestowitz on Thursday 18th of February 2016 11:53:25 PM Filed under
Why Reclusive Linux Creator Linus Torvalds Believes Engineers Should Share Great Ideas
Data Sheet—Thursday, February 18, 2016
The legendary software engineer Linus Torvalds, creator of Linux, sat for an interview in which he provided a fascinating glimpse into his psyche. A self-professed non-people person, Torvalds explained that he likes to work alone—a telling statement from the man who did more than anyone to create the open-source software movement. Open source, said Torvalds, allows people to work together, even if they don't like each other.
TED 2016: Linux founder not a 'people person'
Glorious Jerk Linus Torvalds Trolls TED With Hilariously Frank Interview
Torvalds admits he is not a "people person"
LinuxQuestions.org: Not Your Average Linux ForumSubmitted by Rianne Schestowitz on Thursday 18th of February 2016 10:06:21 PM Filed under
For many of us, our introduction to computing is being placed in front of a machine where the only challenge is figuring out the Windows user experience paradigm. Getting started with Linux, on the other hand, requires a bit more effort, a fair amount of trial and error, and perhaps some colorful language along the way.
Linux was not meant to be open sourceSubmitted by Rianne Schestowitz on Thursday 18th of February 2016 02:17:40 PM Filed under
The Linux community has a lot to shout about. In addition to a seemingly endless choice of distros to suit every taste and need, there's also the highly-prized security. This is helped to a large extent by the open source nature of Linux, but Linus Torvalds has revealed that being open source was not part of the original plan.
Neville Cross: How do you Fedora?Submitted by Rianne Schestowitz on Wednesday 17th of February 2016 10:08:08 AM Filed under
Neville Cross is a Nicaraguan hotel manager who has a passion for technology. He has an Amateur Radio license, and was doing stuff with packet radio (ax.25 protocol) in 2008. That made him look for help in the local Linux community. As he used Red Hat Linux for a while in 2000, it was natural for him to take a look at Fedora. Instead of getting help, he got involved in the local FOSS community, especially in the Fedora local group. At that moment, others Linux distributions had strong support from the international community, but Fedora did not. So he took on the challenge to close the gap. That is how Cross originally showed up in Fedora landscape many years ago.
A man with his Fingers in many millions of piesSubmitted by Rianne Schestowitz on Saturday 13th of February 2016 12:56:19 AM Filed under
At the time of writing, over five million Raspberry Pis have been sold. That's the same as the number of ZX Spectrums sold in the 80s. And like the Spectrum, the Pi is likely to have a far-reaching legacy, helping the next generation of games designers and computer scientists find their feet.
Countless numbers of people have helped make this happen, but Eben Upton has been there from the beginning. He's the founder and the CEO of the Raspberry Pi Foundation, and he's still shaping every aspect of the Raspberry Pi, from its hardware to the software. We met Eben shortly before the launch of the model 2. He told us about the effort they've put into making the Pi better and how a chance conversation with the boss of Google shaped the Pi's future.
Solus Operating System interviewSubmitted by Rianne Schestowitz on Monday 8th of February 2016 12:07:13 PM Filed under
This is where it starts to get a bit complicated… So to start from the end, EvolveOS and SolusOS are the same thing – we had to rebrand. I was living in the UK myself until last year, when I came back home [to Ireland]. So the problem I had is that I wanted to, ironically, protect the project from patent trolls, and in the process I had to apply for a trademark to protect the project. On April Fool's day last year, of all days, I had a letter come through saying that I was going to be threatened with legal action, and I thought it might be about the name Evolve. It actually wasn't – it was about the use of OS! Apparently the Ordnance Survey took a dislike to my using of it, as I was informed that the trademark was held by the Secretary of State – so I wasn't allowed to use my name because of a map maker! When I was trying to explain it to people they were like, 'Well what about Chrome OS? What about iOS?' When I was in the UK at the time, Google was heavily invested with a lot of start-up companies and giving out Chromebooks and that, and that was through a partnership deal with the government. Apple had just furnished the House of Lords and the House of Commons with iPads. I imagine that the Secretary of State was quite happy to ignore the fact that they were using OS in their names… But the small fry like me? So I said, 'Okay, we'll change it.' We went through a week trying to come up with a name, but in the end I decided to go back to the old name, which is where SolusOS comes in.
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Charity Advertising & Marketing Partners Arlington, TX, United States
Charity Advertising & Marketing Partners is offering PAID internships in Marketing / Sales / Advertising! These are FALL / WINTER internships ONLY! We will begin accepting applications for summer interns in April. Candidates MUST be local DFW candidates to be considered, and MUST be available to begin working within TWO WEEKS of receiving an offer of employment. Our interns will gain valuable experience in the following areas: - Marketing, fundraising, and advertising - Basic marketing and advertising psychology - Interpersonal interaction (speaking directly to potential donors on behalf of our clients) - Public speaking and public relations - Organization and time management - Networking and professionalism Because we are in the process of expanding, TOP interns will be given the opportunity to advance into leadership positions within our organization! - Learn how to manage a small team of others - Learn training and coaching techniques - Help coordinate events and establish relationships with venue contacts - Help out with social media and manage our company's brand - Represent our organization at networking events and regional/national conferences - Have access to our exclusive mentorship program and receive guidance from some of the top CEOs in our industry - Earn PAID travel opportunities to other exciting markets (Chicago, NYC, Miami, and more) - Participate in the hiring process, conduct interviews, and evaluate the qualifications of potential new hires We offer a FUN, POSITIVE atmosphere and a young, dynamic company culture! - Regular team outings - baseball games, karaoke, BBQs, Top Golf, and more! - A young, energetic CEO and a management team with an open-door policy - A welcoming, inclusive environment - A team comprised of young professionals from a variety of backgrounds - former college athletes, service industry professionals, law school graduates, and employees from six different continents Interviews will be granted on a first-come basis, and applicants with immediate and open availability will be given preference. We are looking to fill these positions ASAP, so APPLY TODAY to be considered for a role with our organization! Job Requirements: Requirements: - Must be a local DFW resident - Must be availale within two weeks of receiving an offer - Must have reliable transportation and be able to commute to the office on a daily basis - Must be fun, outgoing, and personable! - Must be williing to try new things and develop new skills - Must be able to work both individually and in groups - MUST be able to pass a background check NO experience in sales, marketing, advertising, or fundraising is required, but experience in the following is strongly preferred: customer service, service industry, hospitality, restaurant, host, hostess, restaurant server, kitchen, line cook, bar manager, bartender, bartending, concierge, hotel, help desk, client relations, marketing, promotions, brand ambassador, public relations, events, event planning, event coordinating, event management, fundraising, charity, nonprofit, camp counselor, sports, sports marketing, advertising, marketing management, communications, retail, sales, retail sales, retail management, sales clerk, sales associate, keyholder, sales management, management, fast food, sports management, training, teaching, education, business, business development, marketing communications, product promotions, club promotion, club promoter, cocktail waitress, cocktail waiter, busser, general business, consulting, social media, social media marketing, social media advertising, business development, entrepreneurship, entrepreneur, leadership, public speaking, construction, general labor, internship, entry level


text:
More than 300 staff have been made redundant at stricken electricals retail chain Comet.
Administrator Deloitte announced 330 job losses across Comet's head office and support centres, but stressed there had been no redundancies among shop staff and all Comet's 236 stores remain open.
The bulk of the staff cuts have been made in Comet's head office in Rickmansworth, Herts, as well as its site in Hull and call centre in Clevedon, Somerset.
Deloitte added that it was holding talks with a number of potential buyers for Comet, which collapsed into administration a week ago.
Neville Kahn, joint administrator of Comet, said: "We are in discussions with a number of parties who have expressed interest in parts of the business and we continue to work hard to preserve jobs."
Deloitte added it was seeing record levels of trade after launching a sale across Comet stores yesterday.
They had suspended gift cards from being used in stores last weekend, but this was lifted earlier this week for vouchers purchased and paid for in full by members of the public.
However, Deloitte has maintained the temporary suspension on gift cards which have been issued to people on behalf of a corporate customer.
The collapse of Comet marks one of the biggest high street casualties since the demise of Woolworths in 2008 and came a month after the failure of JJB Sports.
The group was hit by weak high street trading conditions, competition from online rivals and being unable to secure the trade credit insurance needed to safeguard suppliers.
In particular, it was knocked by the lack of first-time home buyers, which had been key customers for Comet, according to Deloitte.
The high street electricals market in the UK has come under huge pressure as cash-strapped shoppers put off purchases of big-ticket items such as TVs and large appliances and online rivals take a bigger slice of the sector.
Comet's administration comes just months after it was taken over by investment firm OpCapita, which bought the chain for a nominal £2 in February.
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This promotion is for Rewards members only. To take advantage of exclusive offers like these, join Office Depot® OfficeMax® Rewards now!
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StarTech.com USB 3.0 to 2.5" SATA III Hard Drive Adapter Cable w/ UASP - SATA to USB 3.0 Converter for SSD / HDD Item # 861670
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Connect a 2.5in SATA hard drive to your computer using a portable cable with UASP Support. The USB3S2SAT3CB USB 3.0 to SATA adapter cable lets you connect a 2.5" SATA hard drive or solid state drive to your computer through an available USB port - the easiest way to upgrade the hard drive in your laptop by adding an external SSD via USB 3.0.The cable supports UASP, allowing for transfer speeds up to 70% faster than conventional USB 3.0, which enables you to utilize the full potential of your SATA III SSD/HDD, when paired with a UASP-enabled host controller.This portable adapter features a lightweight design with no external power required, for easy storage in a laptop bag or carrying case. Plus, the cable-style adapter makes it easy to swap between hard drives without having to install your drives into an enclosure. Perfect for easy drive access for data migration, drive cloning and data backup applications.UASP is supported in Windows 8, Mac OSX (10.8 or above), and Linux. In testing, UASP performs with a 70% faster read speed and 40% faster write speed over traditional USB 3.0 at peak performance.At the same peak in testing, UASP also shows an 80% reduction in required processor resources.Testing results were obtained using an Intel Ivy Bridge system, a UASP-enabled StarTech.com Enclosure, and a SATA III solid state drive.
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|1 x 15-pin Male SATA 3.0 SATA; 1 x 7-pin Male Power
|Connector on Second End
|1 x 9-pin Type A Male USB 3.0 USB
|19.7 in.
|Device Supported
|Notebook; Ultrabook; Storage Drive; Hard Drive; Solid State Drive
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|SATA/USB Data Transfer/Power Cable; 1 x Instruction Manual
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|2-year limited
|1.45 oz
|1.8 in.
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Double Orange Scones
|All purpose flour
|2 Cup (32 tbs)
|Baking powder
|2 1⁄2 Teaspoon
|Grated orange zest
|2 Teaspoon
|Cold butter/Margarine
|1⁄4 Cup (4 tbs), diced
|Drained chopped mandarin oranges
|1⁄2 Cup (8 tbs)
|Skim milk
|1⁄3 Cup (5.33 tbs)
|Egg/Egg substitute
|1 , beaten
|Egg white
|1 , beaten
|1 Tablespoon
Preheat oven to 400 degrees F.
Lightly coat cookie sheet with cooking spray.
In a Ig.bowl, combine flour, 3 tbs.sugar, baking powder and grated orange zest; mix well.
Using a pastry blender, cut in butter or margarine until the mixture resembles coarse meal.
Stir in oranges, milk and egg just until the dough leaves side of the bowl.
Turn dough onto a lightly.floured surface and knead lightly 10 times.
Place on greased cookie sheet and roll or pat dough into an evenly shaped 8-inch circle.
Cut into 8 wedges with a sharp knife; separate slightly.
Brush with beaten egg white; sprinkle with 1 tbs.sugar.
Bake 15-16 minutes or until edges are a light brown.
Immediately remove from cookie sheet and serve warm.
Variation: To make Cranberry Orange Scones, stir 1/2 cup chopped, fresh cranberries with the oranges, milk and egg
Tip: Serve scones with orange butter: In sm.bowl, beat 1/4 cup butter until light and fluffy.
Stir in 1 tbs.orange marmalade; To freeze: Cool bakes scones completely, then wrap in plastic bags; pressing out as much air as possible.
To reheat, spread frozen scones on cookie sheet and heat for about 5 minutes in a preheated 250 degrees F oven.
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 196 Calories from Fat 59
% Daily Value*
Total Fat 7 g10.3%
Saturated Fat 3.9 g19.4%
Trans Fat 0 g
Cholesterol 41.7 mg13.9%
Sodium 184.6 mg7.7%
Total Carbohydrates 29 g9.7%
Dietary Fiber 1.3 g5.1%
Sugars 4.3 g
Protein 5 g9.9%
Vitamin A 4.2% Vitamin C 3%
Calcium 13.9% Iron 9.8%
*Based on a 2000 Calorie diet


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Comfort Inn Valpacos
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Beautiful Surprises
... Baroque style, no corridors and perfect symmetry. Continuing on to the Pinhao region we reach Quinta de Avessada for dinner. We are greeted by Fado music makers and Mr. Bean, the owner. Sipping his wine, nibbling on bread with maramalada and/or cheese we watch the sun set in this wondrous valley. Local and simple food is served, sausages, pork, cabbage and bean soup, chicken , then a herd mentality as dessert is announced. Sleepy bus as we meet our boat in ...
Day at Quinta la Rosa
It was harvest time and we were lucky that they just arrived with the grapes during our wine tasting at our quinta. Afterwards we drove around to visit orther estates and just enjoyed the beautiful scenery. The evening we had a lovely dinner at our ...
7:00 PM - Birthday Dinner
What I thought was going to be a normal dinner, turned out to be much different. John told them that it was my birthday (my birthday is in August, not June). They didn't know, so they decided to celebrate with a homemade cake for dessert.
I was truly touched. I also was very embarrassed. We never did tell anyone the truth.
4:00 PM - Pinhão
Just hanging out, and walking around. Chris and I went into the grocery store. Beef was €5/kilo, which is like $2.75/lb. Sardines, always a favorite, was close to €3. The two of us caught up with Beth for a glass of wine on the way back to ...
10:15 AM - Favaios
... the bakery. There are only 4 ingredients to the bread: yeast, salt, water, and flour. There are only two sets of ovens. The point here is that the process is quite primitive, but the productivity is immense as this lady (and probably others) crank out all this bread that's sold all over Portugal. The samples of that and the wine they gave us to drink - well, no one had any ...


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The number of U.S. radio listeners who tune in at least once a week grew by 1.9 million over the past year, according to new figures from Arbitron, which measured audiences age 12 and up. The biggest growth came in the 18-34 demographic, with a gain of 350,000 listeners. In all, 93.1% of Americans over 12 are tuning in to radio.
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Home > Research > Research Centers & Programs > Center for Rehabilitation Outcomes Research (CROR) > Fellowships & Jobs (CROR)
The Institute for Healthcare Studies at the Feinberg School of Medicine, Northwestern University offers two-year post-doctoral research fellowships in health services research, funded by a National Research T32 Service Award (NRSA). This program is integrated with a National Institute of Disability and Rehabilitation Research (NIDRR) post-doctoral institutional training grant, and both a PhD and MD post-doctoral program in health services research sponsored by the Midwest Center for Health Services and Policy Research (MCHSPR), Hines VA Hospital.
Learn more about the Institute for Healthcare Studies Fellowship
Dr. Miriam Rafferty earned her Doctor of Physical Therapy degree from Washington University in St. Louis in 2006, her Board Certification in Neurologic Physical Therapy in 2010 while working at the Rehabilitation Institute of Chicago (RIC), and her PhD in Neuroscience from the University of Illinois at Chicago in 2015. Dr. Rafferty spends approximately 15% of her time treating patients at RIC, and the remainder of her time completing postdoctoral research training in Health Services and Outcomes Research at Northwestern University. Dr. Rafferty's research focuses on the knowledge translation pathway, facilitating and studying the implementation of evidence-based physical therapy practice in real-world clinical settings.
Three ongoing projects are:
Her long-term research goals include scaling the implementation of evidence-based physical therapy delivery across other diagnoses and across multiple centers, as well as comparative effectiveness research to strengthen the evidence on the long-term effectiveness of physical therapy for the management of people with chronic health conditions and disability. Dr. Rafferty is funded by the National Institute on Disability, Independent Living, and Rehabilitation Research, the Foundation for Physical Therapy, and the National Parkinson Foundation.
345 E. Superior Street - Chicago, IL 60611 | 1-800-354-REHAB (7342) | 312-238-1000
©2017 Rehabilitation Institute of Chicago. All rights reserved.


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text: RT Book, Whole DB /z-wcorg/ DS http://worldcat.org ID 491957213 LA English T1 Laurie A1 Nijssen, Elfi,, Lindenhuizen, Eline van,, PB Clavis PP New York YR 2010 SN 9781605370729 160537072X AB Laurie is a special girl. She doesn't hear well and that can be hard sometimes. She doesn't always understand what other people say and playing with other children can be difficult. Luckily there's the ear doctor. He examines Laurie's ears and gives her hearing aids.


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Peptide therapeutics have traditionally faced many challenges including low bioavailability, poor proteolytic stability and difficult cellular uptake. Conformationally constraining the backbone of a peptide into a macrocyclic ring often ameliorates these problems and allows for the development of a variety of new drugs. Such peptide-based pharmaceuticals can enhance the multi-faceted functionality of peptide side chains, permitting the peptides to bind cellular targets and receptors necessary to impart their role, while protecting them from degrading cellular influences. In the work described here, we developed three cyclic peptides, VP mimic1, VP mimic2 and OT mimic1, which mimic endocrine hormones vasopressin and oxytocin. Making notable changes to the overall structure and composition of the parent hormones, we synthesized the mimics and tested their durability against treatment with three proteases chosen for their specificity: pepsin, alpha-chymotrypsin, and pronase. Vasopressin and oxytocin contain a disulfide linkage leaving them particularly vulnerable to deactivation from the reducing environment inside the cell. Thus, we increased the complexity of our assays by adding reducing agent glutathione to each mixture. Subsequently, we discovered each of our mimics withstood protease treatment with less degradation and/or a slower rate of degradation as compared to both parent hormones and a linear control peptide.
Department of Chemistry, The College of New Jersey, P.O. Box 7718, Ewing, NJ 08628, USA.
This article was published in the following journal.
Name: Bioorganic & medicinal chemistry letters
Pages: 989-95
Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.
Norovirus infections have a major impact on public health worldwide, yet there is a current dearth of norovirus-specific therapeutics and prophylactics. This report describes the discovery of a novel ...
Purification and Biochemical Characterization of a Neutral Serine Protease from Trichoderma harzianum. Use in Antibacterial Peptide Production from a Fish By-Product Hydrolysate.
This study reports the purification and biochemical characterization of an extracellular neutral protease from the fungus Trichoderma harzianum. The protease (Th-Protease) was purified from the cultur...
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.
Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus ...
Total Synthesis of Circular Bacteriocins by Butelase 1.
Circular bacteriocins ranging from 35 to 70 amino acids are the largest cyclic peptides produced by lactic acid bacteria to suppress growth of other bacteria. Their end-to-end cyclized backbone that e...
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7.
Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural ...
Phase Ia Malaria Vaccine Trial of Two Virosome-Formulated Peptides
Influenza virosomes represent an innovative human-compatible antigen delivery system that has already proven its suitability for subunit vaccine design. The aim of the study was to proof t...
Prediction and Testing of Antigenic Sites of the AIDS Virus, HTLV-III Recognized by T Lymphocytes for the Development of Synthetic Vaccines
Subjects are healthy adult volunteers either at high risk for HIV infection or already known to be seropositive, who will donate blood for in vitro tests of T-cell function and in vitro re...
Safety and Immunogenicity Study of Plasmodium Vivax CS Derived Synthetic Peptides Formulated in Two Adjuvants
This was a phase I double blind controlled vaccine trial, evaluating safety, tolerability and immunogenicity of mixtures of N, R and C LSP derived from the P. vivax CS protein formulated i...
A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following Autologous or Allogeneic Transplantation for AML, CML, ALL, MDS, and B Cell Malignancies
The purpose of this study is to determine the safety and effectiveness of administering WT1 cancer peptides. Cancer peptides are short pieces of protein that are made in a laboratory to b...
Immunization of Disease-Free Melanoma Patients With Different HLA-A2 Peptides
Open-label single center study. Patients will be divided in four groups of 7. Group 1: 8 melanoma-specific peptides in saline; Group 2: same mix of peptides + Montanide ISA51; Group 3: sam...
Histology, Comparative
The study of the similarities and differences in the structures of homologous tissues across various species.
Comparative Study
Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs.
A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.
Anatomy, Comparative
The comparative study of animal structure with regard to homologous organs or parts. (Stedman, 25th ed)
Vaccines, Synthetic
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
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Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...
Pancreatitis Acute pancreatitis is inflammation of the pancreas caused by the release of activated pancreatic enzymes. Common triggers are biliary tract disease and chronic heavy alcohol intake. Diagnosis is based on clinical presentation...
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Bake the sweet potato fries as the label directs.
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Photograph by Charles Masters
Recipe courtesy Food Network Magazine
The best comfort food is comforting both to cook and to eat, like Ree's pork chops.


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Delamore, Adrian Wilmot (Acting Sergeant)
|ID number
|Collection type
|Private Record
|Delamore, Adrian Wilmot (Acting Sergeant)
|1 wallet: 1cm
|Object type
|Delamore, Adrian Wilmot
|Place made
|Date made
|Collection relating to Sergeant Adrian Wilmot Delamore, Auckland Infantry Battalion NZ1B at Egypt, Lemnos and Gallipoli. Collection comprises his original diary, covering the period 8 April to 30 July 1915, and a typed transcript. The transcript is divided in two sections.The first half covers 8 April 1915 to 30 July 1915 (the contents of the original diary), the second half covers his first diary, from 22 January to 3 April 1915.
|In the first part of the transcribed diary, Delamore describes travel on the Lutzow, disembarkation on the Isles of Greece, and landing at Anzac Cove on 25 April 1915. Delamore writes of the action and constant shell fire at Gallipoli. He also covers food rations, the censorship of his letters, and the May armistice to bury the dead. He was promoted to Acting Sergeant 13 May and stationed to Quinns's Post 2 June where he describes the closeness of the opposing trenches, bombing, the taking of Turkish prisoners, conditions and terrain. Delamore was evacuated sick with enteric fever, July 1917. He was taken to 1 Australian Hospital at Lemnos and later to Malta. The diary entries at this period describe some experiences in the hospital. In the second part of the transcript, Delamore records the sights and culture whilst serving in Egypt, including an entry on the riot in Cairo on Good Friday 2 April 1915, which became known as the "Battle of the Wozzer". The transcript of the diary has been hand bound in an embossed leather cover.


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when it's sunny your so funny when were in school you make me look like a fool when your near i have nothing to fear when you take my hand then i know it's time for us to dance when you look me in the eyes i know were together for life when you say hello i know it's a start of a new begining when you say you love me then i know i am lucky before you said it was today i felt like i was brave when i hear the sound of your voice i know that i am safe when i fall asleep i dream of you as if you are right here beside me telling me it's alright when you whisper in my ear telling me you will be there when you are blue i know exactly what to do if i see a teardrop running down your face i would quickly wipe it away without you thinking it is me........................
© Copyright 2017 Brennan is so sweet. All rights reserved.
Status: Finished
Genre: Poetry
Book / Fantasy
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