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By Celia Fernandez | 11/13/2015 - 10:23
Christina Aguilera has nothing but well wishes for Gwen Stefani and Blake Shelton.
Read more
By Zayda Rivera | 10/20/2015 - 21:37
Christina Aguilera's daughter is voicing her opinion about Blake Shelton – and it's not good
Read more
By Cristina Arreola | 10/15/2014 - 09:34
It's back to work for Xtina!
Read more
By Priscilla Rodriguez | 03/12/2014 - 09:20
The auditions are over!
Read more
By Cristina Arreola | 02/14/2014 - 09:37
Have you seen Shakira's ultra-sexy new music video for "Can't Remember To Forget You"?
Read more
By Brittany Valadez | 12/02/2013 - 12:46
Although last week was another week of contestant eliminations on The Voice, that's nothing to say for the show itself, which continues to be a ratings hit amongst the reality singing competition shows.
Read more
By Brittany Valadez | 11/13/2013 - 12:18
Two of the top twelve contestants were sent home last night on NBC's The Voice.
It was also the first night of the show's new twist, the "Instant Save."
Fans could instantly save a contestant in the bottom three entirely by logging on Twitter and tweeting a hash tag with a Voice tagline and their chosen contestant's name.
This makes live shows all the more real, as fans are literally, part of the show.
When asked which contestant they thought would be saved, coaches Blake Shelton and Adam Levine said Jonny Gray.
Read more
By Cristina Arreola | 09/20/2013 - 10:18
We love all the Latinas on reality TV, especially Ecuadorian-American The Voice judge Christina Aguilera.
But it seems not everyone loves Christina as much as we do! She's frequently clashed with fellow judge, Adam Levine, on the popular singing competition.
Read more
By Jesus Trivino | 04/23/2013 - 10:29
The Voice's battle rounds continued to boost morale and kill egos last night on NBC. Team Shakira pitted Monique Abbadie against Luke Edgemon with Lady Gaga's "You And I" as the weapon of choice. Before the singers hit the stage, Abbadie said, "I want to be a Latin pop star like Shakira."
Read more
By Jill Pankow | 12/03/2012 - 16:58
Viewers who tuned in to watch Chelsea Lately on Thursday, November 29 may have been tempted to do a double take. The show's host, Chelsea Handler, showed off a barely there black bustier bodysuit and fishnets in an effort to channel Christina Aguilera and make guest and Voice mentor, Blake Shelton, feel more at ease. Let's be honest, though, Handler doesn't pull it off half as well as Aguilera does!
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When: Fri., Feb. 17, 8 p.m. 2012
(Post-Valentine Heart-Break) Punk Rock Cabaret
Price: $8
522 2nd St. (Oakland-Downtown)
After several lineup switches, the members of celebrated Bay Area punk band Cold Beat find their groove as collaborators and evolve towards a more electronic sound.
by Nastia Voynovskaya
February 10, 2016
The connection between the metal communities of Portland and Oakland.
by Ben Salmon
January 22, 2014
Event production company fiveTEN Oakland is trying to change the music and party scene for Oakland's LGBTQ community.
by Zaineb Mohammed
August 28, 2013
Three pop-punk bands — This Time Next Year, Set Your Goals, and The Story So Far — discuss the scene in the East Bay suburb.
by Whitney Phaneuf
November 21, 2012
After losing its lead singer in a van accident on tour, the San Francisco metal returns with a new album and more attention than it knows what to do with.
by Whitney Phaneuf
October 24, 2012
This week we review Mist Giant, The Wounded Men, Afrolicious, and The Slow Poisoner.
by Rachel Swan
October 19, 2011
of 1
Select a star to rate.
Anonymous and pseudonymous comments will be removed.
© 2017 East Bay Express

subset: commoncrawl


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New GM John Idzik is known as a salary-cap guru. Well, he'll have to do a lot of "guru-ing" to fix the Jets. The team's 10 highest cap figures account for $110 million of the projected $120 million cap. Obviously some of these players will be cut to create room, but it still will be a tight squeeze.
The 10 highest cap charges for 2013:
LB David Harris -- $13 million
QB Mark Sanchez -- $12.8 million
WR Santonio Holmes -- $12.5 million
OT Jason Smith -- $12 million
LB Calvin Pace -- $11.6 million
CB Antonio Cromartie -- $10.8 million
LT D'Brickashaw Ferguson -- $10.7 million
C Nick Mangold -- $9.1 million
CB Darrelle Revis -- $9 million
LB Bart Scott -- $8.7 million


text:
Starting a new Business?
Start a business with caution
to be really successful. If you carefully follow all the right steps of creating a company that sells a quality product or provides a service that people want you may be very successful.
Choose a product or service
that people are buying now and spending money on consistently. Think of whether they are spending the money because they want it or need it. This is very important in a down turn of the economy.
Decide on a service
that people are buying or you are sure that people will want to buy. It is a growing need in the market place or has it already peaked and is being replaced by other services?
What is the competition?
How many years have the competition been established? How big is the competition and do they have deep pockets?
Negotiate the right business lease space location
with the best number of years and option. Be careful to negotiate the right inclusions such as building taxes, management costs and included utilities.
Operating cash and operating line credit
is a must as it will take months and maybe a couple of years to get off the ground and realize a before break even point. Of course your goal is not be break even bu to make a good profit.
Equipment, furnishings, leasehold improvements
and office equipment are the next big decision. I would suggest getting help from someone who know the industry before you make some very costly mistakes.
For a lot more information !!
Click Here – To go to my eBook "How to start a business".
I have 17 chapters of information gleaned from 40 years of experience in business that could save you hundreds of thousands of dollars.
Most business people make mistakes during their operation and these mistakes are usually paid for in hard earned cash. Learn as much as you can from the mistakes I have made and paid for. Learn as much as you can and then start your business.
We Advertise Businesses For Sale on the Internet
We have been able to help many companies sell a business by finding buyers, by advertising their company on the internet. Online marketing of their businesses on our website is an opportunity that works.
Entrepreneurs that want to start a small business should get help from an experienced consultant as risking hard earned money must be handled carefully to avoid extensive losses.
Information About Canada
For resource information on Canada and all the Provinces and Territories go to Business Resource Canada which includes population, land area, cities, economy, mining, agriculture, tourism and the energy resource at http://www.businessresourcecanada.com
Business Resource Canada
Webmaster: Cornerstone


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We didn't sneak anything in.... if you knew our member, she can be very
persuasive especially when she wants to.... goes the extra mile and does
it by the book to make it happen.
I do know that all the food had to be shipped separately and in
seal-a-meal bags- Ziploc wasn't good enough.
It was truly a group effort. It was also sent to a -- sorry not a
military person here, so not using the proper terms-- hall where many of
the men and women use during down time to relax. So it wasn't just one
group that got the benefit... many did. We were kinda worried that it
wouldn't really get there... but they did allow her son to call home and
say thanks... He as well as the others there where so surprised and
> Donna,
> what a wonderful thing for your group to have done. The one thing I
> know
> that my nephew needs and can't get over there is hand sanitizer gel.
> he first became an MP, he started using it all the time, because you
> know what you're touching and soap and water isn't always available.
> gave
> him a good sized bottle when he left, and I know he packed what he
> but I'm sure he goes through it quickly. Apparently it can't be sent
> there without a hazmat label because it has alcohol in it. And with
> hazmat label on the box it can be delayed for eternity.
> I may have to get creative. I was successful in sneaking M&Ms in an
> aspirin
> bottle and a kit kat bar in a photo folder to him when he was in
> Any
> ideas?
> Kitty
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text:
gone is a feeling which
spins me out of realm
disbelief is the fortress
shielding pain
you are the rain
which pours
in my heart
© Copyright 2017 leesah. All rights reserved.
Status: Finished
Genre: Poetry
Ooh, how beautiful.
I like a lot.
I'll be honest, i don't really like the first four lines ... but from 'you are the rain' down is outstanding!
And the structure is beautiful.
Well done, love it.
Poem / Romance
Poem / Poetry
Poem / Poetry
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text:
Timberline Lodge Entry
Hello from Timberline Lodge at the 6000' level of Mount Hood, Oregon.
Here's a shot straight out of the camera of the entryway to Timberline Lodge
I have been taking photos since about 3pm this afternoon. Had an excellent dinner and am getting ready to do some more interior shots. It's snowing and blowing outside. I have a room on the third floor and am pretty excited to be here with time on my hands.
Cheers to all of my Flickr friends!
And please visit my web site.
1,626 views
7 faves
22 comments
Taken on January 20, 2010


text:
As more and more customers conduct their banking and other business electronically, whether on a desktop computer or mobile device, simple security precautions should be followed. These easy steps help safeguard your confidential information and your banking data.
To prevent online banking fraud and protect your online accounts, we have enabled several security measures to protect you online.
Security features like:
In addition, we want to do our part to promote cyber security by sharing tips to help you stay safe online. Don't be the next target of an online attacker, keep your information safe!Learn More
All mobile banking options available from Capitol Federal® provide the same high level of encryption for security as True Blue Online® Banking, so you can control your money on the go with peace of mind. Protecting customer account information is a top priority for Capitol Federal, so we've provided tips to help any mobile user increase security.Learn More


text:
It is as infinite as the cycle of seasons,
and the descending of snowflakes on a cool winter morn. . .
It is as passionate as the flames dancing among the embers of the ever burning fire,
and the strikes of lightening in the wild storm. . .
I love you.
© Copyright 2017 Champagne. All rights reserved.
Status: Finished
Genre: Poetry
Short Story / Thrillers
Poem / Poetry
Poem / Poetry
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Results 1 to 4 of 4
- 01-16-2014, 12:07 PM Thread Author #1
Nexus 5 Streaming Video problems...
Hello all,
Love the Nexus so far except that it doesn't seem to be playing well with certain "tube" sites. On my previous phones (HTC One, Galaxy S3), whenever I would click on a streaming video link, it would launch an external player like MX Player to play the video. However, on the Nexus, MX player will launch but never load the streaming video. I've used a variety of browsers, including Dolphin, Android Browser and Firefox but every time MX Player just seems to be stuck at the loading screen and never plays the video.
Any ideas?
- 01-23-2014, 11:24 AM Thread Author #2
Re: Nexus 5 Streaming Video problems...
I think the problem is on Tmobile's end. I can stream fromt he tube sites when I'm on my home wifi network just not while on my mobile connection. Very strange since I turned off T-mobile's webguard.
- Posts
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Re: Nexus 5 Streaming Video problems...
Do you just have a weak cell signal?
Sent from my T-Mobile Note 3 using AC Forums.
- 01-23-2014, 01:54 PM Thread Author #4
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For Manuscript Submission, Check or Review Login please go to Submission Websites List.
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|Table of Contents
|Vol. 94, No. 3, 2011
Issue release date: November 2011
|Section title: At the Cutting Edge
From Targets to Treatments: A Review of Molecular Targets in Pancreatic Neuroendocrine TumorsWiedenmann B.a · Pavel M.a · Kos-Kudla B.b
aDepartment of Hepatology, Gastroenterology and Endocrinology, Charité Medical School, Berlin, Germany; bDepartment of Pathophysiology and Endocrinology, Silesian Medical University, Katowice, Poland Corresponding Author
Bertram Wiedenmann
Division of Hepatology and Gastroenterology, Department of Internal Medicine
Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum
Augustenburger Platz 1, DE–13353 Berlin (Germany)
Tel. +49 30 450 553 022, E-Mail firstname.lastname@example.com
Pancreatic neuroendocrine tumors (pancreatic NET) are relatively rare, slowly growing tumors, although their incidence is increasing, and patients may survive for several years with metastatic disease. Apart from symptomatic relief, there have been few treatment options for these tumors in the past. More recently, investigators have explored the potential of molecularly targeted agents in treating pancreatic NET, with some success. In this review, we consider the data supporting exploitation of different targets in pancreatic NET, including peptide receptors, receptor tyrosine kinases (involved in tumor angiogenesis and more directly supporting tumor growth), and intracellular targets, such as the mammalian target of rapamycin (mTOR), which has a central role in regulating cell growth, metabolism, and apoptosis. Probably due to the paucity of pancreatic NET, many clinical trials to date have included heterogeneous NET populations, and there are few randomized studies of this specific patient population. Very recently, promising results have been achieved in placebo-controlled, phase III trials with the multitargeted tyrosine kinase inhibitor, sunitinib, and the mTOR inhibitor, everolimus. These agents have been approved or are currently being reviewed by authorities for use in patients with pancreatic NET. Here we review potential molecular targets in pancreatic NET and summarize the available data for targeted agents from phase II and III trials open to patients with this tumor.
© 2011 S. Karger AG, Basel
Pancreatic neuroendocrine tumors (pancreatic NET) are increasing in incidence [1,2] and, with improved diagnostics and better recognition within the medical community, their prevalence is higher than previously thought [3]. The natural course of the disease varies according to the type of primary tumor, tumor size, and histological grade. Symptoms arising from hypersecretion of hormones or amines occur in less than half of all cases. The lack of specific symptoms in nonfunctional tumors leads to an often higher tumor mass at first presentation compared with their functional counterparts. Approximately two thirds of patients with pancreatic NET have distant metastases at diagnosis [1].
Recent years have seen a dramatic increase in the number of molecularly targeted agents to treat cancer as a result of our increased understanding of the processes and pathways involved in tumorigenesis. This paper focuses on molecules identified as potential treatment targets in pancreatic NET and reviews the latest data on experimental antitumor agents acting at these targets.
A number of potential therapeutic targets have been identified and are currently under investigation for treating pancreatic NET (fig. 1) [4].
The first 'targeted' treatments for pancreatic and other types of NET were somatostatin analogs, used since the 1980s to alleviate symptoms of hormonal hypersecretion. Somatostatin analogs are still a key component of treatment today, and further exploration of the somatostatin receptors (SSTRs) as relevant targets has yielded new approaches to diagnosis and treatment.
Somatostatin and Its Receptors
Somatostatin, an endogenous cyclic peptide, regulates the secretion of growth hormone, insulin, glucagon and gastrin [5]. It acts through a family of seven G protein-coupled transmembrane receptors with five distinct subtypes (SSTR1–5) [6,7]. Activation of SSTRs has a variety of direct and indirect effects [8]. Direct antiproliferative effects include inhibition of the cell cycle, inhibition of growth factor effects, and induction of apoptosis. The literature suggests that these effects may be mediated by the PI3K/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), and Ras/extracellularsignal-regulated kinase (ERK) signaling pathways [9,10]. Indirect effects include inhibition of the release of growth factors and trophic hormones, inhibition of angiogenesis, and modulation of the immune system [8]. Studies of receptor distribution in different types of pancreatic NET show that receptor expression is widespread (50–100% of tumor samples across different studies), with more than one subtype commonly expressed in a given tumor [11,12,13,14]. However, expression appears to vary with histological type, as well as between patients with the same tumor type. Nevertheless, expression of SSTR2 and SSTR5 is found in approximately 90 and 80% of pancreatic NET tumor cells, respectively, and pancreatic NET is potentially sensitive to hormone treatment [15]. Somatostatin itself has a very short half-life (∼3–4 min) [7]. Attempts have therefore been made to synthesize somatostatin analogues such as octreotide and lanreotide that have high affinity to SSTR2 and SSTR5 but lack the disadvantages associated with somatostatin [7,16].
Other Peptide Receptors
Successful exploitation of the SSTR for both diagnostic and therapeutic purposes in managing pancreatic NET has led to increased interest in the distribution of other peptide receptors. The limited evidence available suggests that receptors for bombesin, cholecystokinin, and vasoactive intestinal peptide are all expressed to some degree on at least some types of pancreatic NET [17,18,19,20,21].
Angiogenesis is a central and complex process in tumor growth and metastasis, and involves a number of receptor tyrosine kinases (RTKs) and their ligands. The importance of angiogenesis in the development of pancreatic NET is supported by studies in the RIP1-Tag2 mouse model [22,23], discussed in more depth below.
Vascular Endothelial Growth Factor Receptor
Both vascular endothelial growth factor (VEGF)-A and its receptors, VEGFR-1 and VEGFR-2, are constitutively expressed in normal islets as well as in pancreatic RIP1-Tag2 tumors [24]. Using the same model, VEGF-A was shown to be critical for the angiogenic switch, as well as for tumor growth [25]. Inhibitors of VEGFR significantly reduce pancreatic tumor growth or cause regression of established tumors in treated mice, compared with controls, and also disrupt tumor vasculature [26,27,28,29,30].
Several studies have investigated the expression of VEGF, VEGFR, and other markers of angiogenesis in tumor biopsy samples from patients with pancreatic NET (table 1). Taken together, the studies suggest that VEGF may be only weakly expressed in many pancreatic NET, but is strongly expressed in at least some cases. There are conflicting data on whether VEGF expression is highest in benign tumors [31,32] or (specifically VEGF-C expression) in well differentiated neuroendocrine carcinomas [33,34], and on whether or not microvascular density (MVD) is correlated with VEGF expression [31,32,33,34].
In a single study, expression of VEGFR-2 and VEGFR-3 in neoplastic cells was variable, but (in a preliminary comparison) was possibly correlated with ligand expression in both primary and metastatic tissue, suggesting that VEGFR may be involved in regulating growth or survival of some pancreatic NET [33].
A recent study reported high uniform expression of Angiopoietin-2 (Ang-2) messenger RNA (mRNA) in endothelial cells of both nontransformed pancreatic tissue and pancreatic NET tissue [35]. Interestingly, epithelial mRNA Ang-2 expression occurred exclusively in pancreatic NET cells. Increased microvessel density and enhanced lymphatic metastasis were evident in Ang-2-expressing tumors, indicating a functional role of Ang-2 in experimental NET. Consistent with this notion, circulating Ang-2 was significantly elevated in patients with NET, compared with healthy controls. Furthermore, elevated Ang-2 levels were correlated with presence of metastatic disease, with the highest concentrations found in patients with liver metastasis. Ang-2 concentrations above the 75th percentile predicted shorter survival (p = 0.0003). These findings are supported by other studies of patients with NET [36,37]. Significantly elevated levels of serum Ang-2 levels (p = 0.01) were found in patients with NET (n = 47; 17 with pancreatic NET), compared with healthy controls (n = 44), and the time to disease progression was shorter in those patients with serum Ang-2 levels above 4,756 pg/ml (p = 0.04) [37]. The induction of Ang-2 in pancreatic NET may, therefore, represent a clinically relevant mechanism of disease progression and could constitute an adverse prognostic marker [35].
Platelet-Derived Growth Factor Receptor
In a single series of human pancreatic NET samples, both platelet-derived growth factor receptor (PDGFR)-α and PDGFR-β were commonly expressed in primary and metastatic tumor cells, as well as tumor stroma [38]. PDGFR-β expression was upregulated in primary pancreatic NET and metastases compared with normal endocrine pancreatic tissue, and in tumor stroma compared with normal pancreatic stroma [39]. In a gene profiling study, PDGFR-β was upregulated in pancreatic neuroendocrine carcinomas with metastases compared with benign pancreatic NET [40].
Inhibitors of PDGFR significantly reduce tumor growth or cause regression of established pancreatic tumors in treated mice compared with controls, and also disrupt tumor vasculature [26,27,29,30].
Stem Cell Factor Receptor (c-Kit)
Several studies have demonstrated expression of c-kit in human pancreatic NET tissue samples [38,41,42,43]. The proportion of positive samples ranged widely from approximately 14–90% between reports, and within one study varied substantially with the type of antibody used to detect c-kit [41]. Inconsistencies between studies may therefore be related to technique rather than necessarily reflecting a real variation in c-kit levels. Recently, c-kit expression has been identified as an independent prognostic marker for pancreatic NET [44].
Epidermal Growth Factor Receptor
Several immunohistochemical studies have reported epidermal growth factor receptor (EGFR) expression in human pancreatic NET samples [38,45,46,47,48,49]. Estimates of the proportion of samples expressing EGFR range from 18 to 65%, with variation in the intensity of staining also reported. The variation between studies may reflect differences in the patient populations or antibodies used [48]. Although there is some debate as to whether EGFR expression can be used as a marker of malignancy in NET [46,50], a recent study found that the expression of EGFR correlated significantly with the grade of malignancy in pancreatic NET, increasing from low levels of expression in benign tumors and those of uncertain behavior to high levels of expression in well- and poorly differentiated tumors [49]. Furthermore, patients with pancreatic NET expressing activated EGFR have been found to have significantly worse prognosis than those with tumors not expressing activated EGFR [48]. Targeted therapy against the EGFR tyrosine kinase domain may therefore prove to be a useful therapeutic approach for pancreatic NET.
Sarcoma Kinase
Sarcoma (Src) family kinase activity has been shown to regulate adhesion, spreading, and migration of pancreatic NET cells in vitro [51]. The Src-like kinase, LCK (lymphocyte-specific protein tyrosine kinase), was found to be significantly upregulated at the RNA level in both primary and metastatic pancreatic NET compared with normal islets, with a 4.35-fold difference (p = 0.02) [52]. Immunohistochemical findings also supported the upregulation of LCK. However, there was no significant correlation between LCK staining and stage, differentiation, proliferation, functional status, or clinical outcome.
Combining Angiogenic Targets
The pathways involved in angiogenesis are heavily interlinked. For example, dual inhibition of VEGFR and PDGFR results in a greater antiangiogenic effect in the RIP1-Tag2 model than selective inhibition of VEGFR or PDGFR alone, with substantial decreases in both endothelial cells and pericytes [53]. A therapeutic approach combining several targeted agents or using a single, multitargeted agent, may therefore be of greater value than using an agent directed at a single target alone.
Targeting intracellular molecules, such as those mediating signal transduction downstream of RTKs, offers yet another potential therapeutic approach. One established target is mTOR, a serine/threonine kinase with a central role in regulating cell growth, metabolism, and apoptosis.
Mutations in specific tumor suppressor genes known to regulate mTOR appear to be associated with an increased risk of developing pancreatic NET. These regulatory genes include, most notably, phosphatase and tensin homolog (PTEN) [54,55], the tuberous sclerosis complex 2 gene (TSC2) [56,57,58] and, possibly, neurofibromatosis type 1 [59,60]. In a recent gene expression profiling study using a large panel of pancreatic NET, PTEN and TSC2 were downregulated in most primary tumors examined [61]. Downregulation was significantly associated with shorter disease-free and overall survival (OS), supporting a role for the PI3K/Akt/mTOR pathway in the development of pancreatic NET.
Several additional potential therapeutic targets have been identified by research into pancreatic NET. Expression of these targets is summarized and referenced in table 2. One target worth more detailed discussion is the dopamine receptor; targeting this receptor is showing potential in treating other tumors and may be of benefit in NET.
Dopamine Receptors
Dopaminergic drugs have been shown to inhibit human small-cell lung cancer growth both in vivo and in vitro [62], and it has been proposed that they may also have an antiproliferative effect in secreting pancreatic NET [63]. Several studies have investigated dopamine 2 expression in NETs [64,65,66,67]. Grossrubatscher et al. [65] showed high expression of these receptors in 85% of NET tumors studied; most tumors were located in the pancreas (n = 15) and the lung (n = 14). Dopamine 2 receptor immunoreactivity was present in 93% of the islet cell tumors studied. Generally, high positivity was reported in more than 70% of tumor cells, particularly in bronchial and pancreatic tumors. The authors conclude that there may be a role for dopaminergic drugs in inhibiting secretion and/or cell proliferation in NETs. Interestingly, co-expression of the dopamine 2 receptors with SSTR2 and SSTR5 has also been found, with higher expression of the dopamine receptors in low-grade rather than high-grade NET [67]. Kidd et al. [68] report variable expression of dopamine 2 and somatostatin receptors depending on cell type and tissue of origin, with differential cytotoxicity induced by chimeric compounds. A somatostatin/dopamine chimeric compound may therefore be a viable therapeutic option.
This section focuses on agents in phase II or later development (table 3). The clinical data are notable for their heterogeneity with respect to the enrolled patient population and for the current lack of randomized trials, stemming in part from the rarity of the tumors.
Somatostatin Analogs
Currently available somatostatin analogs comprise octreotide and lanreotide, available as depot formulations; octreotide is also available as an immediate-release formulation. The question of whether somatostatin analogs – predominantly used for symptom relief – have any antitumor activity has been hotly debated. Prospective and retrospective clinical studies have revealed that the use of somatostatin analogs is associated with tumor growth stabilization in 50–60% of gastroenteropancreatic NET patients, whereas partial tumor remissions rarely occur [69,70]. However, there are limited data in pancreatic NET exclusively. In a prospective study of 21 patients with pancreatic NET treated with octreotide long-acting release (LAR), 38% had stable disease (SD) after a median follow-up of 49.5 months. While one prospective placebo-controlled study confirmed an antitumor effect in midgut NET, the applicability of the data to pancreatic NET remains unclear [71,72,73]. Recent data have shed light on the biological effect of octreotide, with the demonstration that SSTR2 (located in the cell membrane in untreated patients) becomes internalized following high-dose octreotide therapy in patients with NET [74].
Potential advances in this area include the development of somatostatin/dopamine chimeric compounds [68]; the pan-somatostatin analog pasireotide, which has affinity for SSTR1, SSTR2, SSTR3, and SSTR5 [75,76]; and also non-peptidic somatostatin analogs with high affinity and selectivity for SSTR1 [77,78,79] and SSTR3 [80]. These compounds have yet to be tested for efficacy.
Peptide Receptor Radiotherapy
The presence of SSTRs on gastrointestinal and pancreatic NETs has been exploited to achieve targeted delivery of radiotherapy, using radiolabeled somatostatin analogs (indium-111, yttrium-90, or lutetium-177). Results from phase II trials of patients with various types of NET have shown that radionuclide treatment using 90Y-DOTATOC ([90Y-DOTA]-D-Phe1-Tyr3-octreotide) produces partial responses (PR) in 4–35% of patients [81,82]. Recently, Cwikla et al. [83] found 90Y-DOTATATE ([90Y-DOTA⁰, D-Phe1-Tyr3]-octreotate) to be effective in patients (n = 60) with gastroenteropancreatic NET; 23% had PR and the remaining 77% of patients had SD. Response rates with 177Lu-DOTATATE ([177Lu-DOTA⁰, Tyr3]-octreotate) are also encouraging in patients with several types of pancreatic and other gastrointestinal NET, with an objective response rate (ORR) of approximately 43% (complete response 4.4% and PR 38.5%) in the pancreatic NET group [84]. To date, prospective studies comparing 'hot' with 'cold' somatostatin analogs with respect to their symptom-controlling as well as their antiproliferative efficacy are lacking.
Sunitinib is an oral, multitargeted RTK inhibitor of VEGFR-1–3, PDGFR, c-kit, RET, CSF-1R, and FLT3, with direct antitumor and antiangiogenic effects. In the RIP1-Tag2 transgenic mouse model of pancreatic NET, sunitinib reduced tumor burden and increased survival, reduced the endothelial cell population, and reduced pericyte coverage [29,53]. In a phase II clinical trial in patients with advanced carcinoid (n = 41) or pancreatic NET (n = 66), the overall ORR was 16.7% in patients with pancreatic NET, and a further 68% had SD [85]. Median time to tumor progression (TTP) was 7.7 months and 1-year survival was 81.1% in patients with pancreatic NET. A phase III, randomized, double-blind trial of sunitinib versus placebo in patients with progressive, well-differentiated, malignant pancreatic NET was closed early because of the greater risk of progression and death in patients assigned to placebo [86]. Median progression-free survival (PFS) with sunitinib was 11.4 months and with placebo was 5.5 months (hazard ratio 0.42; 95% CI 0.26–0.66; p < 0.001). Based on these positive results, the European Commission approved sunitinib (SUTENT®, Pfizer Inc.) for the treatment of unresectable or metastatic, well-differentiated pancreatic NET with disease progression in December 2010.
Sorafenib is an orally active, multikinase inhibitor with selectivity for the RTKs VEGFR-2, VEGFR-3, PDGFR-β, FLT3, c-kit, and RET, as well as for the serine/threonine RAF kinases, B-Raf and Raf-1/C-Raf, which are associated with activation of these RTKs. To date, results have been reported from a single phase II study of sorafenib, which included two cohorts of patients with, respectively, gastrointestinal tumors (n = 50) and pancreatic NET (n = 43) [87]. In patients with pancreatic NET, the ORR was 10%, and 14 of 23 evaluable patients (61%) were progression-free at 6 months.
Vatalanib inhibits all known VEGFRs, with particular selectivity for VEGFR-2; at higher concentrations vatalanib also inhibits PDGFR-β and c-kit. One phase II trial is ongoing in patients with progressive, advanced NET (NCT00590343); however, no specific data on pancreatic NET have been published [88]. In another study, 4 of 20 patients enrolled had pancreatic NET; overall, the best response was SD (8/16 patients at 6 months) in heavily pretreated patients, with a median TTP of 7 months [89].
Imatinib is an orally available phenylaminopyrimidine analog which specifically inhibits tyrosine kinase activity associated with c-kit, PDGFR-α, PDGFR-β, and BCR-ABL. Imatinib inhibited cell proliferation and induced apoptosis in both c-kit-positive and c-kit-negative neuroendocrine cells in vitro [42]. Although imatinib has been investigated in some types of NET [90,91], few patients with pancreatic NET have been enrolled and there is currently no evidence of clinical activity in this tumor type.
Gefitinib is an EGFR-specific tyrosine kinase inhibitor. Blockade of EGFR using gefitinib inhibited growth of pancreatic NET cell lines in vitro, inducing apoptosis and cell cycle arrest [92].
The activity of gefitinib has been assessed in a phase II study of patients with advanced NET [93]. PFS at 6 months was 31% for 29 evaluable patients with pancreatic NET; 2 of these patients achieved a PR and 4 patients had SD exceeding 4 months.
Bevacizumab is a monoclonal antibody that binds to, and neutralizes, all biologically active forms of VEGF. In preclinical experiments, bevacizumab failed to inhibit growth of BON pancreatic NET cells in vitro, but reduced their angiogenic potential by blocking the cells' ability to stimulate endothelial cell tube formation and proliferation [94]. Treatment with bevacizumab impaired tumor growth in a xenograft model using BON cells.
In a phase II study of bevacizumab plus temozolomide in patients with advanced NET [95], 18 of 34 patients enrolled had pancreatic NET, of whom four (24%) achieved a PR and a further 12 (70%) exhibited SD. Two ongoing phase II trials are open to patients with advanced NET, including those of pancreatic origin [96,97]. In a study of bevacizumab combined with the oxaliplatin-based chemotherapy regimen, FOLFOX (oxaliplatin, leucovorin, and 5-fluorouracil), 2 of 6 patients with pancreatic NET enrolled achieved a PR and 4 had SD [98]. Since comparative trials of chemotherapy versus chemotherapy plus bevacizumab are lacking, and chemotherapeutic drugs alone may induce high remission rates in pancreatic NET (as has recently been shown by the use of capecitabine and temozolomide [99]), it remains an open question whether the addition of bevacizumab to systemic chemotherapy increases response rate or PFS.
Everolimus is an orally available derivative of rapamycin, which inhibits the activity of mTOR. Preclinical studies have shown the antiproliferative effects of everolimus in human pancreatic endocrine cells in vitro and in vivo [100,101]. Application of everolimus was also associated with attenuated phosphorylation of all downstream targets of Akt, including TSC2, mTOR, and p70S6K [100], and with G0-/G1-phase arrest, as well as induction of apoptosis [101].
The combination of everolimus plus octreotide was investigated in a phase II study in advanced, low-to-intermediate grade NET [102]. Among 30 enrolled patients with pancreatic NET, 8 patients obtained a PR (27%) and 18 had SD (60%). Median PFS in this group was 50 weeks; median OS had not been reached. Another phase II study of everolimus in metastatic pancreatic NET after failure of chemotherapy has recently been published [103]. Patients with progressive disease who were not being treated with octreotide at study entry received single-agent everolimus (stratum 1; n = 115), while patients who had been on octreotide LAR for at least 3 months, but also had evidence of progression, received everolimus plus octreotide (stratum 2; n = 45). In stratum 1, 9.6% of patients achieved a PR and 67.8% had SD; in stratum 2, 4.4 and 80% of patients had a PR or SD, respectively, as their best response. Median PFS was 9.7 months and 16.7 months in strata 1 and 2, respectively. A phase III, randomized, double-blind trial of everolimus plus best supportive care versus placebo plus best supportive care in patients with progressive, well-differentiated, malignant pancreatic NET confirmed the activity of everolimus. Median PFS with everolimus was 11 months and with placebo was 4.6 months (hazard ratio = 0.35 [95% CI 0.27–0.45]; p < 0.0001) [104]. Estimates of the proportion of patients alive and progression-free at 18 months were 34% (95% CI 26–43) with everolimus, compared with 9% (95% CI 4–16) with placebo. Based on the results of this phase III study, regulatory submission for everolimus to treat patients with NET is underway.
Like everolimus, temsirolimus is a rapamycin derivative with specific activity against mTOR. To date, a single phase II trial of temsirolimus in advanced NET has been published [105]. Among 15 patients with advanced pancreatic NET and 21 patients with gastrointestinal tumors enrolled, 1 patient with each tumor type achieved a PR (ORR, 6.7 and 4.8%, respectively). The overall median TTP was 6.0 months, and one-year PFS was 40.1%. Median OS had not been reached.
Dual Therapeutic Targeting
Combined targeting of mTOR and EGFR signaling pathways has shown potential clinical benefit in the RIP1-Tag2 model, compared with inhibition of either pathway in monotherapy [106]. A phase II trial is ongoing to evaluate the efficacy of this treatment regimen in human NET (NCT00843531).
A number of agents directed at molecular targets that appear relevant in the pathology of pancreatic NET (as discussed above) are currently in phase I or early phase II clinical development (table 4); these include, in particular, agents directed at SSTRs and insulin-like growth factor type 1 receptor (IGF-1R), as well as an inhibitor of histone deacetylase.
In summary, pancreatic NET are a diverse group of tumors which vary in their degree of malignancy and functionality. Before the development of targeted agents, several systemic options were available to control tumor growth and improve patients' quality of life, including interferon therapy, somatostatin analogs and cytotoxic chemotherapy. While chemotherapy may induce significant tumor shrinkage, these effects are transient. Researchers have therefore investigated molecular targets that offer scope for new therapeutic approaches that could significantly improve management of patients with pancreatic NET. We have undertaken an extensive review of published literature on targets specific to pancreatic NET, and have summarized the available clinical data for agents directed at some of these targets.
Preclinical experiments have demonstrated the relevance of angiogenesis in the development of pancreatic NET. Several RTKs with both angiogenic and direct roles in supporting tumor growth are expressed to varying degrees in human pancreatic NET biopsies, although interpretation of the published literature is complicated by differences in technique. In the clinic, preliminary activity in pancreatic NET has been reported with several RTK inhibitors. Most notably, the multitargeted RTK inhibitor, sunitinib, has recently demonstrated superiority over placebo in a randomized phase III study and has received approval by the European Commission for treating patients with pancreatic NET.
The PI3K/Akt/mTOR pathway, with its critical role in regulating cell growth and apoptosis, is also implicated in the growth of pancreatic NET. The mTOR inhibitor, everolimus, has demonstrated activity after failure of chemotherapy in a large phase II trial and superiority over placebo in a placebo-controlled phase III trial. Everolimus and sunitinib are the two most advanced of all molecular targeted drugs in the field of NET and can be considered similarly effective in pancreatic NET with respect to PFS.
In conclusion, several targeted agents have potentially useful activity in pancreatic NET. More randomized, carefully designed studies are urgently needed to assess the real benefits of these agents, either alone or in combination. The rarity of pancreatic NET means that enrollment is likely to be slow, and cooperative, multicenter studies will be needed to progress development in a timely fashion.
Medical writing support was provided by Andy Gannon and Jean Scott of ACUMED® (Tytherington, UK) with funding from Pfizer Inc.
Financial Support: Medical writing support was provided by Andy Gannon of ACUMED® (Tytherington, UK) and was funded by Pfizer Inc.
Bertram Wiedenmann
Division of Hepatology and Gastroenterology, Department of Internal Medicine
Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum
Augustenburger Platz 1, DE–13353 Berlin (Germany)
Tel. +49 30 450 553 022, E-Mail firstname.lastname@example.com
Received: October 26, 2010
Accepted: May 14, 2011
Published online: August 31, 2011
Issue release date: November 2011
Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 4
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: http://www.karger.com/NEN
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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Press Release
Unconventional Photography Methods Highlight Bridges in SJU Gallery
PHILADELPHIA (June 2, 2015) — Elements of unpredictability and intentional imperfections add new dimension to Vaughn Wascovich's photography in his exhibit "Bridging Cleveland," which will be on display at Saint Joseph's University Gallery from Monday, June 8 until Saturday, Aug. 1.
Doctors, Admins Graduate from MBA Program as a Team
If you had asked Lee M. "Monty" Duke II, M.D. '15 (MBA) about his future career plans when he was a young boy growing up in Vienna, Va., he would have told you he was going to be a professional baseball player. A lifelong lover of the sport, Duke played on the men's baseball team at the University of Virginia, where he earned his bachelor's degree in psychology.
SJU to Graduate First Class of Educators of the Deaf and Hard of Hearing
PHILADELPHIA (May 1, 2015) – Saint Joseph's newly established, Pennsylvania Department of Education approved program for the preparation of teachers of the deaf and hard of hearing will graduate its first cohort of students in 2015: two this month, and another four by the end of the year. The M.S. program includes an online-only curriculum, which through the help of technology will prepare future teachers in educating individuals who are deaf and hard of hearing.
From High School Dropout to High Tech Entrepreneur
Growing up in Queens, N.Y., as the son of Armenian immigrants, Toros Asadourian '15, never quite imagined his journey would lead him to Austin, Texas, by way of Philadelphia. After dropping out of high school at the age of 16, the now-co-owner and partner of c2h2 Network Solutions, an Austin-based IT support company, tried his hand at internships, jobs and community college, to little avail.
Saint Joseph's University Hosts Class of 2015 Commencement Ceremonies
SJU will celebrate the Class of 2015 on Saturday, May 16, by conferring nearly 2,400 doctoral, graduate and undergraduate degrees at the University's 164th Commencement ceremonies.
Student Leader Garners Top Food Marketing Job
For the student body president and graduating senior Claire Tedesco '15, the Saint Joseph's experience has been about self-discovery, learning to lead, and understanding the impact of her actions – all in preparation for some pretty big aspirations.
SJU Graduate Receives New York Women in Communications Scholarship
Saint Joseph's University senior Leigh Anne Tiffany of Blue Bell, Pa., was one of 18 young women selected to receive the highly competitive New York Women in Communications Scholarship, and one of two chosen to receive support for graduate school.
Finance Major en route to Scotland on St. Andrew's Scholarship
PHILADELPHIA (May 5, 2015) — Saint Joseph's University sophomore, Morgan Bui of Fairfax, Va., has been awarded the Andrew Mutch Scholarship by the St. Andrew's Society of Philadelphia. The $20,000 award will allow Bui to continue her studies at the University of Edinburgh in Scotland, during her junior year.
SJU Announces Details of Sculpture to Mark 50 Years of New Catholic-Jewish Relationship
SJU has commissioned Joshua Koffman to craft an original sculpture entitled "Synagoga and Ecclesia in Our Time," that marks 50 years of a new Catholic-Jewish Relationship.
Saint Joseph's University Joins Entrepreneurship Bootcamp for Veterans with Disabilities Program
The Entrepreneurship Bootcamp for Veterans with Disabilities (EBV), an entrepreneurial and small business education program founded in 2007 at the Whitman School of Management at Syracuse University (SU), and operated by SU's Institute for Veterans and Military Families (IVMF), has announced the expansion of its consortium of schools to include Saint Joseph's University.


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By Deborah Lockridge
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"I really enjoyed this story"
A well read and fun story. It's not incredibly deep but the author does a nice job of making us care about the unique characters and their challenges.
This is one of the best paranormal series I have read. The plot is fantasist if with a very unique twist. I have always read books on Succubus and erotic scene but this time the story does not focus so much on that. It in fact focus more on the good qualities of the heroine with a kind heart. She has guts, very loyal to her friends and goes all out to help them in need. Georgina's and Seth's romance is also very unusual in that they cannot have any lovemaking and it shows how much self- control and love they have for each other to restrain. I cannot wait for the last book to know how it will end. I hope there will be a happy ever after for them. They so deserve it.
"Just as great"
I have read this series and loved it so after to listening to the first book I knew I would be buying them all! Elisabeth Rogers doors a great job.
Todd W. Brown
"Still on the fence"
The series is interesting. I am actually reading/listening to it in an effort to study the genre more closely. This episode was sort of peculiar. I could see some development in Georgina, but her supporting cast remains somewhat cardboard-like. (Opposed to those in Kim Harrison's series.) The "ambrosia of the gods" was a nice line. It sort of reminded me of meth. Having a blast from the past helped build some more of the backstory, but I am still not totally hooked. I did enjoy some of the humor and the sex scenes offered a bit of a clinic as to what the target demographic (mainly women in this case) will accept. I will sally forth and hope it continues to get better.
"Oh' The Heart Ache"
Georgina Kincaid continues to try to find love in all the wrong/right places. With the help of her friends, from both heaven and hell, she finds herself in yet another mystery and personal disaster. What I enjoy about the series is the historical references and lives.
Series I Love:
Kim Harrison- The Hallows
J.R. Ward- The Blackdagger Brotherhood
Charlene Harris- Sookie Stackhouse Series
George R. R. Martin- Game of Thrones
Suzanne Collins- The Hunger Games
"A fun and quick listen"
Yes, it is a sexy little tale of a Succubus who is trying to be a good girl
I would recommend it to my friends who enjoy girlie paranormal reads
I think she captures essence of Georgina rather well
I really like the interactions between Carter and Georgina. They are unlikely and there is clearly more to the story than is being revealed at this time.
"Succubus with a heart"
That Georgina is actually a character that you could be friends with, I did not expect her to be so likable considering that she is succubus.
Its entertaining and she does not come across as evil.
She made the characters sound great, even the men. I would listen to her again.
Not overly reactive, only pleasantly surprised that she is so down to earth.
Im glad there were so many reviews to help me decide to read this one, I may not have chosen it otherwise. It was not sexually offensive as one may expect with such a subject matter. Its a good read with characters that you can enjoy.
"Spoilers ahead"
STOP READING IF YOU DO NOT WANT SPOILERS! I generally DO NOT like cheating in the main romantic characters but with one of the main character being a succubus I wanted to see how they work around that (she must do 2 humans a month) but I couldn't see them getting around no sex rule for Seth I figured that may have led to his getting involved with someone else,but we find out in this book that Georgina cheats with Bastain (he shapeshifts into Seth)but she knows he is not Seth so I am not real happy with Georgina right now. I mean her original cheating with her husband should have taught her the lesson. Ms Mead does such a great job with her story and other characters that she draws you in and you feel so much for Georgina so even thought cheating usually keeps me away from books, I have enjoyed the first 2 immensely (but I have to take this much heart breaking angst in small doses)
Becca Poody
"not for me"
This book was really boring. Returned it for another book. The first book was also boring and I thought this one would get better.
Reading is a must-have ESCAPE...
"Improvement over 1st Installment"
The story of Georgina picks up immediately where Succubus Blues, Book 1 leaves off. However, enough is explained/reviewed that one can follow without having read Book 1. New characters are introduced and more of her life as a mortal is recalled. On Top employs a dual plot approach that are largely unrelated, so each chapter has much to explore. Bastion, an incubus from her past, plays a central role in one of the two plots. He's most certainly entertaining and pushes the nature of their 'friendship.' He exits at the story's conclusion and leaves the reader a tad bereft. Seth and Georgina's relationship develops despite Georgina's poor choices. Curious to see how Seth's character evolves further into the series.
Rodgers audio interpretation of the story and characters does improve over the Blues. Overall, enjoyable read.


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Jim, would it grow in N. FL?? I love doing garden stuff w/ my grandsons when
I can get the sports equipment out of their hand!..& thanks for the digital
----- Original Message -----
From: Island Jim <email@example.com>
To: <email@example.com>
Sent: Sunday, May 04, 2003 6:02 PM
Subject: [CHAT] miracle fruit
> hi,
> i've got a few miracle fruit ripe. that's the fruit that you eat before
> eat a lemon to make the lemon taste sweet. it does something goofy to your
> taste buds--makes sour sweet and [i'm not sure about this part] vice
> it grows readily from seed and makes a quaint greenhouse plant, although
> nothing about it is striking. but, of course, it's something to devil the
> grandpups with, and that's always worthwhile.
> ---------------------------------------------------------------------
> To sign-off this list, send email to email@example.com with the
> message text UNSUBSCRIBE GARDENCHAT
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE GARDENCHAT


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A replacement connector accessory for dimmer packs. 60 Amps, male connector with threaded studs.


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Nice hotel, close to little restaurants and shops, really beautiful beach and territory. Very old and dark rooms - really need makeover, we ha в a huge cockroach the first day we arrived! Breakfast is of a really mediocre quality. We have dined in their restaurants too, but food is nothing exceptional (comparing to small restaurants in the village), however is terribly overpriced.
the view of the sea and the great beach internet was expensive although was very slow and reciption girl was not friendly with us.
Location was excellent.Resort was clean and tidy at all times and staff were extremely friendly and helpful.
I liked the beach and the quiet atmosphere. I liked being in a private chalet Old furniture and expensive price
Everything, that's helpful, isn't it? Everything is perfect, you don't need to change a thing. You have achieved
The ametinities, facilities, staff and environment are all perfect. It is a real gate away to have a memorable holidays. We had a perfect time in the resort.
Beautiful hotel and location, staff V.friendly Check in was an issue - we arrived at 1pm and although check in was supposed to be 2pm, we didnt get into our room until 3pm / / also the restaurant was pricey and the service in it was V.poor
Room proximity of the pool, beach & restaurants The food was not so good as for a 5 star hotel
The hotel itself. It has 30 acres of its own land which has lots of fun activities.
Everything Food is expensive
Excellent resort - unbelievably attentive staff. Good food and great location.
Very helpful staff, good service, lots of activities provided for lots of insects - beware of bites! very quiet at night, so if 2-3 nights might be enough if you like a bit of nightlife or choice of restaurant!
Very Courteous staff, Secluded Private Island with Private Beach. Facilities such as Kayaking, Cycling, Golf carts for quick travel were memorable. Fantastic Indian food. Based on your information on web we have booked Superior sea view Rooms. But the rooms were really in very Bad condition. I surprised; how can a Hotel gets a Five Star category with such ridiculous, cheap, dirty budget rooms. The Reservation Manager was very adamant with some prejudice. Somehow he agreed to shift us in same valued Garden view Deluxe room which eased our stay. But we really wasted a full day to settle the things. I will suggest to delete booking for Superior Sea view room from your portal.
The pool area was very comfy with lots of umbrellas. The beach was all yours to walk and the water was perfect. Was muddy at low tide but very interesting to see.
Calm, Clean, Nice Personel Depending on the hotel's boat to get to and from Cenang Village, also it's close to the airoport, so one hears very often planes
relaxation trial to take money without benifit
The location was excellent. Very peaceful and calm place to be. Very nice Honeymoon hideaway for my wife and I.
Nothing I booked the hotel for 4 nights and had to check out the second day. I wouldnt have checked in if it wasnt midnight in the first place, room smelled bad, mosquitos, lizards, stains on pillows bedsheets. It was really bad, even though i knew i wont get any refund. I still checked out and latter i would say that was my best decision.
Excellent service and value for money. NO
the view
not much: the place is very run down and is certainly not worth being rated as a 5 star hotel, from the 3 restaurants 2 are closed and you are forced to use the buffet in TL-light: all together for us a reasons to leave after one night,... besides: they say at the information that monkey will not come to the houses: think again... there was not much that we did like
Location and facility's near the hotel . Need to be more clean and comfortable .
Super location , near to the Cenang beach , near to the market , 15 mint drive to the air port ,20 mint drive to the cable car and sky bridge . There is a good wifi around the hotel . The standard room size is good enough for 2 people . Staff is very friendly and helpful . there is all option available outside the hotel like rent a car , rent a bike and all watersports activities available just by the walk. Bathroom need to some maintenance because Is not clean enough and lit bit smelly , mattress and pillow is not comfortable. The furniture is very old and the cup condition is not good enough. The price is quitly high .


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20-something girl to friend: I'm sorry, but what is the big fucking deal with eating on the sidewalk? Back courtyard? Sure. Rooftop? Fuck, yeah! But the fucking sidewalk? Homeless people up in my face. Loud trucks up in my ears. Carcinogens up in my lungs. I mean… really? New Yorkers are all fucked up. –2nd Ave b/w 6th & 7th Overheard by: Dodd Loomis Ditzy blond tourist: New York is the most foreign place in America I've ever been to! –F Train Overheard by: Chelsea S. Indian guy on phone: I don't wanna be like the Bengali fob! I'm gonna show up and be like the original New York gangsta! –B61 Bus Bar customer to table next to him: I need to visit New York, everyone that visits is always happy. Everyone that lives here in New York is always miserable. –Chambers St Little boy, with great excitement: I just tripped in New York City! –Times Square
Archive for the 'Desi' Category
Just When You Thought You'd Experienced All the Ways to Be Rejected by a Woman
Indian-looking woman in sari: Achoo! (sneezes)
Man: Bless you.
Indian-looking woman in sari: Oh, no. Thank you. –Busy Laundromat, Astoria
These Aliens Sure Can't Pass for Human
Girl #1: You know, I've never met a gay person that wasn't West Indian.
Girl #2: Really?
Girl #1: Yeah. You know [Toby] in the office? He came in today and asked me how much time off he could get when he gets married to his boyfriend.
Girl #2: But he's bald!…And he's not West Indian.
Girl #1: Oh yeah. –3 train
Just Like Nicole Richie
Black street dealer: Coke? Weed, my brotha?
Desi dude: I'm not black, I'm Indian, my nigga. –St. Mark's & 3rd Overheard by: Innocent XXX
Overheard in Wednesday One-Liner
20-something dude to another: It's so hard to get laid in this city before 11 pm! –M-15 Bus Hottie: I am in New York City. You need to make $250,000 to live like a white person. –28th & 29th Overheard by: A black person from Chicago 20-something male to female: So you'd better be prepared. It's like the Times Square of New York. –16th St & Union Square Overheard by: Annie B Middle-aged Hispanic dude to Indian salesperson: This is New York City. Nobody's gonna kill you, okay? –Rite-Aid Young gay man: That's what I hate about New York City. It's such a fucking small town. –14th St & 2nd Ave Overheard by: molls
Now That's Customer Service
Indian counter-person #1 to girl buying beer: Do you want a straw?
Girl: No, thanks.
Indian counter-person #2: I hear you get more fucked up if you drink it from a straw. –Spring & Mott Overheard by: Clannah
Wednesday One-Liners Got the Part!
Conductor in thick Indian accent: Everybody's stressed out on their way to work, but remember you only came on the train with two hands! If you feel a third hand on you, feel free to do whatever you want with it! –Uptown A Train Overheard by: megan rose Young woman on cell: Daddy? Mommy said you called. Is it about your testicles? –78th & Lexington Overheard by: Bob Man on cell: I just saw this human female walk by with these legs… –SoHo Overheard by: Another human female Passing female coworker: Stick my finger up to the middle knuckle to make sure it's warm. –31st St Dorky guy to friends: So then she gets on the table and the next thing you know, one leg is over her head and I just didn't know what to do with myself… –3rd & 23rd Overheard by: tila Jersey lady: Now I have to straddle him, hold on to his ears, and do it. –Metro North Train Overheard by: Wow. Just… wow.
Disney's Going After North Korea Next
Brown girl: Oh my god, did you see the new Cheetah Girls movie? The one where they go to India? It's so offensive!
White friend: To what? Cheetahs?
Brown girl: Brown people? –Stuyvesant High School
Wednesday One-Liners: Ribbed for Her Pleasure
Loud office chick: Oh my god, I found, like, four condoms on the bookshelf! –Hudson St Overheard by: Harriet Vane Serious teen on cell: If you use a condom… It doesn't count. –Murray Hill 40-something woman to two 20-year-old men: Don't believe any girl when she tells you she's on birth control. Take your condom and keep it in your wallet. –19th St & 5th Ave Overheard by: McCrum Guy on cell: You're just mad because your dick is tiny and the condom slipped off. –Greenpoint, Brooklyn Powerwalking Indian woman: I mean, isn't that why I went on the pill? So guys can come in me? –40th & Queens Blvd, Queens Overheard by: Ohmarkus
Pretentious hipster: So where are you ethnically from?
Indian girl: India.
Pretentious hipster: Well, I know that, but are you from Bangladesh, Pakistan, or India?
Indian girl: India.
Pretentious hipster: Ohhh, you're Native American.
Indian girl: I'll take that drink now. –Welcome to the Johnsons Bar, Lower East Side Overheard by: blondie


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- Lightning cable
- 6 ft
- Lightning port
- Lighting to USB 2.0
Quality issue 02/07/2014
This review is from: Coboc Light-black 6 ft. MFi Certified black Apple 8-pin Lightning Connector to USB Cable for Apple iPhone5, iPad4, iPad Mini, iPod Touch 5th Gen, iPod Nano 7th Gen - Charge and Sync Cable
Functions just like the OEM cable.
The outer insulation separated from the strain relief near the lightning connector after a few weeks of moderate use. The wires inside are exposed now, so I don't expect it to last much longer.
Other Thoughts:
I'm about as easy on my equipment as anybody, so it's pretty rare that things fall apart on me. This wasn't even my primary cable - I use it less than 50% of the time.
This looks like a poor design. The strain relief was made with almost no overlap over the outer insulation, so this separation was inevitable.
1 people found this review helpful. Did you? Yes / No Thanks for the valuable feedback you provided!


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- yumyum
- Reviews: 2649
Hotel Mayak: Sleep on a ship
Hotelship Mayak is moored by the river station and it's your cheapest bet in Krasnoyarsk. We had a cheap room with the toilet on the corridor and the shower was on a different floor. The room made the impression of a prison cell. The bed was a small berth with a thin matress. The window was not terribly securly locked but we managed to secure it as people can walk past the window.

The room with two beds cost 400 roubles in October 2004. There is no breakfast included.
Sometimes the ship's restaurant is booked for wedding parties and then you will hear disco music almost all night long, so bring earplugs to be on the safe side. Otherwise it's an ok budget accomodation. There is no visa registration here which shouldn't be a problem if you only stay a couple of nights.
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Someone I care about needs this: Don't give up. You matter. We need you.
Just Like Water
Have you ever read or heard a similar concept from different people in a short amount of time, as if the Universe was trying to tell you something? That happens to me and when it does, I pay attention. I was reading about Bruce Lee saying that his whole philosophy was to live like water and to fight his opponent not as rock, but as water. How very Taoist. Read more here…
Creativity from author Elizabeth Gilbert
Here is an inspiring podcast I heard today of writer Elizabeth Gilbert (author of Eat, Pray, Love) talking about the creative muse. Full of gems not to miss, this podcast is a treasure trove of great ideas. References to musician Tom Waits abound. Listen to hear … (read more).
My thoughts listening to drumming master Vinnie Colaiuta
Vinnie is great at playing for the song. Check out what I write about Vinnie here when he plays on one of Sting's albums.
I updated my Bio.
Reason 4 by Propellerheads is some of the best software ever designed for musicians.
When I am writing songs I use Reason 4 a lot. I have not upgraded to the newest version as of 02/10/15 and yet I still can't believe how great this software is! The graphic interface is inspiring. It feels like a mad-scientist's playful laboratory. Even with this older version, the possibilities of sound generation are infinite. The code is stable and super-fast which means older computers, like my 2008 Macbook Pro, can run this software like a top. The cpu meter barely moves though I can have dozens of synthesizers and effects stacked into a chain. Incredible! I highly recommend this software for the creative musical spirit in you.
The other excellent part of Reason is it will teach you everything you need to know about running all the components of a recording studio while teaching most of the fundamentals of electronic music synthesis. Just the factory presets without any further effects or routing are rich and inspiring. When you add the metaphorical patch cords, CV control and FX, the sound generation possibilities are jaw-dropping and compete with any outboard gear I have heard. The biggest problem I have is being tempted to explore the sounds and synthesis without actually writing any songs, so I try to work with discipline and focus. Talk about schooling! Reason is a fun way to create and be educated. My hat is tipped to the brilliant programmers and creators at Propellerheads in Sweden. This software has been around for 14 years for both Mac and PC. You get so much for your money. Hey I wasn't paid for this endorsement.
When it's snowing out and I get the winter blues, there's no reason not to get creative with Reason!
The two heaviest words in human history are the hardest to do.
This old hermit guy from Ancient Greece changed my life back in my twenties. For a better world, please consider his words.
Thank you Dennis Chambers (and your mom)!
Dennis Chambers, one of the world's greatest drummers, is a genius. He not only plays great and as close to perfect as I've ever heard, but he has innovated an approach to the drum kit that is an evolution from what Steve Gadd was doing. Many drummers are great, but few innovate and reinvent the instrument. Dennis plays pure music on the drums, very melodic, not brash drumistic athleticism like a lot of good drummers. He's got that too, but his playing seems to always have Bach or a kind of melody, like Max Roach, that makes good compositional sense. I was blessed to meet Dennis serendipitously at a bar in Columbus Ohio. Here's what I asked him:
Dennis, that funk stuff you've got going on with the weaving snare ghost notes, plus the snare accents, plus the kick drum plus the ride cymbal woven with the occasional non-patterned bell of the ride, did you develop that before or after George Clinton and P-funk?
"I had that stuff down BEFORE P-funk!"
That's an amazing answer because it means he had developed his breathtaking coordination when very young. It's difficult to hear that intricate coordination he does on P-funk records because it's pure simple disco funk beats, more or less, with very little fills. So it makes sense he developed that amazing style of playing before P-funk. I will speculate here and say I'm not sure he could've developed such magical coordination playing in P-funk: the band was huge and in huge bands drummers must play more simple so everything can be heard. Simple helps the groove but rarely develops extreme coordination. The recordings change drastically when you check out Dennis with John Scofield, ah, now his playing opens up and one can hear all the subtleties of his playing. This was the band that introduced Dennis to the jazz and fusion world, with the album Blue Matter. When I heard that I thought the sky had fallen, heaven had come down from above. The drums would never be the same again. My practicing changed drastically after I heard Dennis!
"Are you ambidextrous?", I asked Dennis. "Yes."
The grand gem of the discussion I had with Dennis blew my mind. It would be wrong of me not to share what he said. Here is a gift for the world and for all artists to consider:
"My mom told me that of all the great qualities a person could have, the greatest quality is to be honest with yourself."
Thank you Dennis for sharing that incredible wisdom from your mother to me.
The Native Americans saw our future.
I must beat my drum now for a mature audience. The indigenous peoples were horrified at how the White Man talked about and treated the environment. We are bearing dangerous fruit now for having ignored their warnings. Indigenous peoples saw the Long Road Ahead: We are a part of nature, we are of nature, we sprouted from nature even if it was guided by the hand of God. Those who choose to forget this interconnectedness with nature get eliminated by nature. Nature and physics will always win. No one in their right mind would defecate in their drinking water but we do similar things to our environment all the time: look at oil and its by-products, the thousands of liquid chemical toxins and plastics in our water supply and the world's oceans. I'm tired of not saying anything about this. Here I am writing about something that greatly concerns me. Click Here to read on…
On perfectionism and making mistakes
Mistakes used to be my enemy. I have learned to question my perfectionism, to scrutinize it, making more peace with my mistakes. Somehow in my past, I don't know why, mistakes I made upset me and I would abuse myself with denigrating self-talk. I am much better now after years of work. I've learned I can make mistakes my friend instead of my enemy. Mistakes are great teachers, perhaps the best teachers and now when I make a mistake, I celebrate, saying: "Yay! What can I learn from this?" My life is more rich and peaceful because of this re-framing of the word "mistake".
Thomas Edison failed by trying nearly 1000 filaments until he found the right filament for the invention of the light bulb. His learning from mistakes changed history. Indeed, failure is a learning process and presents itself as an opportunity. Failure is not a negative thing. With introspection and grit, one can make failure a coach, a teacher.
It's the ego that is wrapped up in perfectionism. Learning the connection between ego and perfectionism was enlightening for me. I was particularly tough on myself when I made mistakes on the drums because I've been playing since I was seven, how could I still make errors? I am always wondering how my musical heroes deal with mistakes, because some of them, like drummer Dennis Chambers, sound perfect all the time.
I have been learning over the years that my reaction to my mistake is key to not making it a mistake at all! Listen to what jazz vibraphonist Stefon Harris says about making mistakes on this Ted Talk, and learn how perfectionist doctors come to grip with their own mistakes. The final story of this podcast is about a brilliant woman researcher who chose opposition and resistance in order to prove her theories. This is inspiring stuff!
Put this audio Ted Talk into your smartphone or mp3 player, take it with you, and may you be more liberated.


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Hunt for the Engineer: How Israeli Agents Tracked the Hamas Master Bomber
Yehiya Ayyash, the Palestinian bomb builder known simply as "The Engineer," killed 130 Israelis & wounded nearly 500 during a two-year campaign of terror, beginning on April 6, 1994. The Engineer became the most wanted man in modern Israeli history. Prime Minister Rabin ordered the state to mobilize all its resources to stop the bombings. The result was one of the largest manhunts in recent history. Here is how the Shin Bet, the most elite of Israel's secret services, conducted a merciless search & destroy mission against one man. At last they killed him by placing a sophisticated bomb in his cellular phone. By then, however, Hamas had succeeded in derailing the peace process. "Reads like a thriller." Photos.
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The hotel Pineta dell´Iguana is located in between the delights of the Ligurian coast – Portofino and Cinque Terre. It is set on a hillside overlooking the antique fishing village of Cavi di Lavagna, and is only a 5 minute walk to the sea. Follow »
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Hotel La Pineta Iguana
Lavagna (∼42,6 km from Province of Genova)
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Hotel Assarotti
Genova (∼0,8 km from Province of Genova)
»Hotel ** - Via Assarotti 40c - Genoa (GE)
Our hotel is situated in the heart of the eight-hundred years old city. It's open all year and with pleasure we try to meet the customers' requirements The WI FI internet connection is available and FREE in all rooms and common area At yours ... Follow »
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Hotel Bellevue
Genova (∼2,6 km from Province of Genova)
»Hotel *** - Salita Provvidenza 1 - Genoa (GE)
In a central position, situated 50 m. from the railway station 'Principe' as well as from the Air Terminal and 200 m. from the harbor (stazione marittima) Airport 6 Km. away. Follow »
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Albergo Argentina
Genova (∼1,0 km from Province of Genova)
»Hotel * - Via Gropallo / 4 - Genoa (GE)
The Argentina Hotel is located in Genoa, in a central and calm position, just a few steps from the railway station Genoa Brignole. Follow »
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Hotel Bologna
Genova (∼5,0 km from Province of Genova)
»Hotel * - Piazza Sup. Del Roso 3 - Genoa (GE)
Hotel Bologna is situated in a charming location surrounded by stunning buildings, including the Palazzo dei Rolli, a UNESCO World Heritage Site. Follow »
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Balbi Family Hotel
Genova (∼2,3 km from Province of Genova)
»Hotel ** - Via Balbi 21/ 3 - Genoa (GE)
The Hotel Balbi is a family hotel in a historical building with frescoes and hardwood floors.The owners serve on the young hotelkeepers committee of the province of Genoa. Follow »
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Park Hotel Suisse
Santa Margherita Ligure (∼26,2 km from Province of Genova)
»Hotel **** - Via Favale 31 - Santa Margherita Ligure (GE)
AN OASIS OF TRANQUILLITY IN THE GULF OF TIGULLIO If You appreciate tranquillity, You are looking for respect of your privacy, You love nature and the sun, the Park Hotel Suisse is the ideal place for Your holidays on the Ligurian Riviera. Follow »
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Calgary Cancer CentreThe Request for Proposal for the design and construction of the Calgary Cancer Centre is underway.
Questions and Answers on upcoming Request for Qualifications (RFQ) and Request For Proposal (RFP) for the Calgary Cancer Project
Federal Infrastructure Plan: Phase Two
Minister Brian Mason and the Honourable Amarjeet Sohi, Minister of Infrastructure and Communities, recently hosted the first federal, provincial and territorial meeting between ministers responsible for infrastructure. The group met to discuss infrastructure priorities across the country, including future work under Phase 2 of Investing in Canada, the Government of Canadas $120-billion infrastructure plan.
Capital Plan invests in Albertans, supports jobs and economy
Capital Plan 2016 is a thoughtful, responsible plan. It supports the key social programs and services that government provides to Albertans, encourages economic development, and supports environmental outcomes.
Building and Modernizing Albertas Schools
In Alberta, about 200 school projects are underway to provide new and modernized schools for families and communities across the province. Follow the progress of school projects underway in your community by visiting projects.alberta.ca.
Royal Alberta Museum Reaches Construction MilestoneOn August 16, 2016, the Government of Alberta along with the Government of Canada marked a construction completion milestone of the new Royal Alberta Museum.
A Brandon Elm tree, representing a new beginning for the museum, was planted outside the main entrance.
From left to right: Amarjeet Sohi, Minister of Infrastructure and Communities; Randy Boissonnault, Parliamentary Secretary to the Minister of Canadian Heritage and Member of Parliament for Edmonton Centre; Ricardo Miranda, Minister of Culture and Tourism; Brian Mason, Minister of Infrastructure.
While some minor finishing work continues both inside and outside, the facility is at the stage where work can begin inside outfitting the museums galleries and exhibits.
Infrastructure Minister Brian Mason presented Ricardo Miranda, Minister of Culture and Tourism, with the golden key to the facility.
Read the News Release
Learn more about the new Royal Alberta Museum
Last updated: Feb 02, 2017 13:56
Federal, Provincial and Territorial ministers discuss Phase 2 of federal infrastructure plan - September 7, 2016


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HPI Racing Aluminum Mount & Retainer Set
HPI Racing
This item is discontinued and no longer available for purchase. You may want to search our site for a similar item.
This is the replacement exhaust pipe mount and retainer set for the HPI Savage family of monster trucks.
This product was added to our catalog on May 8, 2006.


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Kangaroo Express' Salute Our Troops campaign is back for a second year to help the USO. The campaign – which goes from June 27 through September 4 – invites guests of 1,600 Kangaroo Express stores across 13 states to donate funds to support the USO's mission of lifting the spirits of troops and their families. To help raise awareness and excitement, they've sent out a caravan on tour featuring custom patriotic vehicles – including a very special motorcycle.
In Sept 2008, Romulo "Romy" Camargo was shot in the neck during a firefight in the mountains of Afghanistan. The bullet shattered his C-3 vertebrate, which left him paralyzed from the shoulders down. Romy, a Coral Springs, FL native, is currently recovering at the James A. Haley VA Medical Center in Tampa. With his wife Gabriela and their two-year-old son at his side, Romy became a mentor, providing inspiration to other wounded soldiers and their families that are just beginning the recovery process. Despite his paralysis, Romy's dream was to ride again.
And so it become a mission for many. Izzy Izquierdo, owner of Lefty Brothers Motorcycles in Fort Bragg, NC donated his spare time to design and build a custom motorcycle for Romy. "As soon as I left the hospital, " Izzy said, "I told my wife Barb I was going to build a bike to be dedicated to Romy." Izzy spent countless hours designing a one of a lend custom bobber and attached sidecar that holds Romy and his motorized wheelchair safely. It's done, and it's now traveling with the Kangaroo Express Salute the Troops caravan, helping raise money for military organizations like the USO! - Vyque White, USO Director of New Media
More from the USO
Feb 9, 2017
Baking a Difference: Dog Tag Bakery Provides Job Training and Community for Transitioning Service Members
Upon first glance, Dog Tag Bakery seems like any other cafe. But one look at the patriotic décor – like the dog tag chandelier – and it's clear there's more going on behind the counter than cake decorating.


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ALBANY, N.Y. -- Appearing on The Michael Kay Show on ESPN New York 98.7 Thursday, general manager Jerry Reese said injured cornerback Terrell Thomas has a visit scheduled with Dr. James Andrews and that the team is "hoping for the best."
"That's all I can say about that right now," Reese said. "Hopefully he'll be able to maybe rehab it and come back at some point in the season, but we don't know yet. We really absolutely don't know right now."
Kay asked Reese if cornerback Prince Amukamara, the Giants' first-round pick in 2011, would take Thomas' starting spot.
Reese was asked recently what expectations he had for Amukamara and said he expected him to play like a first-round draft pick. Reese expanded on that quote on the show.
"But I also expect [Jason Pierre-Paul] to play like a first-round draft pick, I expect Hakeem Nicks to play like a first-round draft pick. David Wilson, all those guys. We expect them to play like first-round draft picks, but it got stretched in a lot of different directions. We do. We expect [Amukamara] to step in and play well.
"We do have some young players that we like that can fill some roles. We have 10 corners on the roster right now, so I think we have some guys that can fill in those positions. If Terrell doesn't come back, next man up has to play."
Reese also touched on a number of other subjects:
•Second-year safety Tyler Sash was suspended four games for violating the NFL's Performance Enhancing Drug policy earlier this week. Reese said he believes in Sash's innocence, but it's not up to him. "The league office, they do a good job of making sure everybody abides by the rules. You can't just take a guys word. Tyler's a good kid and we'll get him back after four games. The best part about it is he'll be able to play through the preseason for us and after the last preseason he will have to leave for four weeks."
•Kay brought up the possibility of wide receiver Plaxico Burress making a return. "You never say never. I learned a long time ago to never say we have no interest because you never know when you'll get a rash of injuries at the position and you have to call on some guys."
•On former Giants Super Bowl MVP quarterback Phil Simms telling USA Today that Tom Coughlin and Eli Manning are sure-fire Hall of Famers. "That's not for me to judge. I think they have a tremendous start, but I don't think either one of those guys are focused on that. We're just focused on this season. They're not resting on their laurels. … Those guys are hungry as ever."
SALSA STAYS: Wide receiver Victor Cruz was asked by Kay if he had any plans on reinventing himself with a new touchdown celebration in place of his famous salsa dance.
"I think I'm going keep it the same, man," Cruz said. "Who knows? It will probably be spur of the moment -- something else might come up. But I think I'm going to keep it basic. I think my grandmother wouldn't be too thrilled if I changed it."


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Welltrough Hall Farm Caravan Park
Lower Withington, Cheshire, England Show on map
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If a person sees a river flowing with wine and such a river flows through lush and green land with which he is not familiar, drinking from such a river or entering such land is a glad tiding that the observer will attain Jannah. But if he does not consume such wine or does not […]
Search Results for: pen
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Sweet Smelling Flowers
Fragrant flowers such as roses, jasmine, narcissus, marigold, daisies etc.- if any of these are seen detached from its stem-it suggest that the observer will lose his accumulated wealth. But if they are not, it is a harbinger of a son who will be good, hones and righteous. How righteous he will be depends on […]
A Thorn Tree
If a thorn-tree is seen in the dram, it means the observer of the dream will suffer some harm caused by some person. It could also be a forewarning of an impending calamity.
Earthquakes and Tremors
These are forewarnings of certain major happenings in the world. A quake on mountains points towards evil Ulama. A quake on one's own body suggest that one is bereft of all goodness and worthiness. A tremor is one's house suggest that his house will become a venue for adultery. To seen an entire house or […]
Opening a Closed or Locked Door
If the house whose door is being opened is known to him it means he will marry. If not, it means his Dua's will be granted.
Mountains and Hills
Mountains and hills represent people, their ranks and positions depending on the hugeness, height and mass of such mountains and hills. The same applies to boulders and rocks. The person who sees such a dream will attain honour and dignity.
A bathroom or hot bath symbolizes grief caused by women. But since a person normally spends very little of his time in the bathroom it means his grief with be short-lived.
Soil and Mud
These symbolize grief, sorrow and fear. Their magnitude depends on how much soil or mud is seen.
Drinking Water
Consuming clean, sweet water in the dream means he will enjoy a clean and happy life provided he does not know its quantity nor is he aware of himself being in a state of tuhr nor does he know himself to be on a journey in a strange, unknown place. The same applies if the […]
A Stream in the House
A clean stream with sweet water flowing in or through the house symbolizes a pure and clean life. But if the water is seen in the form of a spring emitting gfrom within the walls or any such place from which the flowing of water is regarded as strange and absurd, if suggest that the […]


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More precisely, FOREX is a currency trading market, and it is one of the largest and most rapidly developing markets on the planet. Over 2.5 trillion dollars are turned over on the forex every single day. That is more than 100 times the amount turned over daily on the NASDAQ. So, what is a market? Simple: it's a place where goods are traded. The forex is no different, but with one little twist: the goods traded on the forex are national currencies. For example, on the forex you might pay in American dollars and buy some Canadian dollars. Or, you could sell your euros for Japanese yen. There is nothing more to it than that. It is one of the most talked-about advantages of trading on the Forex-the commission-free trades! Unfortunately, while we would all like to think that Forex brokers are just out there executing trades for the fun of it, the simple truth is that everyone needs to make money-even the brokers.While they may not charge a traditional commission, brokers on the Forex still make their money whenever trades take place.
We are actually compensated in a number of ways, including:
- Buying/Selling Currencies
- Earned interest on deposited funds
- Converting and holding currencies
- Rollover fees
It is in the buying and selling of currencies that we make the majority of our Spread.


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News By Tag
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Urban Juice Design & Print Cranswick Pet Products Brochures
Urban Juice creative design studio, Grimsby, design and print two brochures for Cranswick Pet Products.
The UK's leading manufacturer of food and accessories for the bird and small animal markets, Cranswick Pet Products recently approached Urban Juice and asked them to update two of their pet product brochures, Nature's Feast and Bucktons.
The first brochure for Nature's Feast Wild Bird Care, featuring a comprehensive range of innovative wild bird foods, feeders, treats and accessories was not just updated but re-invented from the roots of the previous brochure.
The brochure was divided into categories for easy navigation, with clean-cut product details displayed in tidy and subtle tables. The incorporation of high-end product photography in the corporate literature instantly helped emphasize the premium quality on offer.
The second brochure for Bucktons, featuring a unique range of bulk foods and accessories for racing pigeons, indoor birds, aviary birds and wild birds, was tailored to suit the needs of retailers, offering a guiding hand to product selection.
The company wanted to express their commitment to cleanliness, consistency and quality in the design of their new brochure and the graphic design team at Urban Juice made sure products were clearly identifiable to retailers through the use of imagery and product classifications.
Whilst the two brochures were for differing brands and varieties of products, Urban Juice still wanted to include some ties in with each brochure as they ultimately belong together in the Cranswick Pet Products range.
The brochure cover layouts were made similar and horizontal divides were used with positioning allowing them to sit comfortably together.
To read the full story and to preview the brochures, please visit the Urban Juice website at: http://www.urban-
Urban Juice offer a comprehensive range of graphic design services to cater for all of your business needs, from graphic design and print management, company branding, corporate identity design, brand guidelines design, logo design, business card design, stationery design, folder design, annual reports design, brochure and catalogue design, poster, leaflet and flyer design, packaging design, illustration, advertising and marketing, point of sale, exhibition materials, banner and display stand design, to vehicle livery design, photography, website design and ecommerce, email marketing and social media.
For more information about their corporate literature, brochure and catalogue design services, please check out the Urban Juice website at: http://www.urban-
Why not call Urban Juice Graphic Design Agency Grimsby today to discuss your project requirements and see how they can help your business?
# # #
About Urban Juice, Graphic Design Studio Grimsby, Lincolnshire:
Urban Juice pride themselves on being able to apply their creativity to every brief and deliver the client's message with the required impact.
With over fifty years combined graphic design experience, Urban Juice have helped many companies from small and medium sized businesses to large corporations. They work very closely with their clients to develop suitable plans of action and they create exquisite designs to suit their client's needs and budget.
For all your creative design needs and to view their exceptional graphic design portfolio, please visit the Urban Juice website: http://www.urban-
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Apple Pancakes
|2 Cup (32 tbs)
|2 Tablespoon
|Baking powder
|4 Teaspoon
|1 Teaspoon
|2 , separated
|2 Cup (32 tbs)
|Melted butter
|2 Tablespoon
|1 Cup (16 tbs), grated peeled
"Combine flour, sugar, baking powder and salt in mixing bowl.
Beat egg yolks until thick and lemony; beat egg whites until stiff peaks form.
Combine milk, egg yolks and butter in small bowl; mix well.
Add to flour mixture; beat until smooth.
Stir in apple; fold in egg whites.
Pour batter by 1/2 cupfuls onto hot ungreased griddle; cook until puffy and bubbly.
Turn; brown other side.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1790 Calories from Fat 459
% Daily Value*
Total Fat 52 g79.7%
Saturated Fat 27.4 g137%
Trans Fat 0 g
Cholesterol 532.7 mg177.6%
Sodium 3847.9 mg160.3%
Total Carbohydrates 283 g94.4%
Dietary Fiber 12.5 g50.2%
Sugars 80.1 g
Protein 54 g107.7%
Vitamin A 36.5% Vitamin C 18.4%
Calcium 209.7% Iron 89.6%
*Based on a 2000 Calorie diet