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Sell Handrail Fittings Like Glass Clamp Bustrade - Chinaprice: contact company for price
2.Surface:Satin or mirror
3.Suit tube:33.7/42.4/48.3/50.8mm
4.Delivery:By ship, by plane or by express, 20-25 days from production to delivery
5.Payment: T/T or L/C
6.Package: Clean poly bags+ white box+ carton .
7.Function:handrail staircases of apartment, balcony, building, deck, garden and so on.
8.Customer design and OEM: Our engineer team can offer technical support on customer design, based on your smaple or drawing.
Company Contact:
- Posted By: Qingdao FTZ international trading Co., Ltd
- Phone: 8615275238318
- Address: Room C ,the 12th floor, Building B,No.37 Jinduhuay, Qingdao, China
- Email:
- Website: http://www.ftzchina.com
Published date: April 18, 2013 -
- Business Description: Qingdao FTZ International Trading Co., LTD is located in Qingdao, China. We specialize in the production of all kinds of handrail and balustrade fittings in stainless steel AISI304 and AISI316. With more than 10 years of export experience, our products are exported to America, Canada, Russia, EU market and Brazil and well appreciated by our purchasers.
With registered capital of 5 millions RMB, our factory covers an area of 14,000 square meters, FTZ has strong comprehensive competitiveness. Please rest assure our sales team will take care of your order, and the technical team will offer solutions on customer design.
High technology and perfect after sales service are always served for you. FTZ serves all the customers with good quality, competitive price and credible attitude. We will strive to innovate to seek for higher quality and satisfying service to the customers.
Related listings
Sell Handrail Fittings Like Glass Clamp Bulatrade Flush JoinerMetal Manufacturing - Qingdao FTZ international trading Co., Ltd - China - April 18, 2013 - contact company for price
1.Material:Stainless steel 304 or 316 2.Surface:Satin or mirror surface treatment 3.Suit tube:33.7/42.4/48.3/50.8mm 4.Delivery:By ship, by plane or by express, 20-25 days from production to delivery 5.Payment: T/T or L/C 6.Package: Clean poly bags+ w...
Permanent Magnetic Lifter PicturesMetal Manufacturing - YanTai LongHai Hoisting Equipment Co Ltd - China - April 17, 2013 - contact company for price
permanent magnetic lifter use to lift and transport steel and iron for factories, docks, warehouse, transportation and more areas. Can lift and transport steel plate, steel cylinder-form work pieces. Permanent magnetic sucker have compact and durable...
Cold Drwan 2 200mm Stainless Steel Round Bar Rod Factory Direct SalesMetal Manufacturing - Jiangsu Huajie Stainless Steel Products Co,.Ltd - China - April 17, 2013 - contact company for price
Key Words:Cold Drwan 2-200mm Stainless Steel Round Bar/ Rod More Key Words:AISI 201 cold drwan round bar, stainless steel Rod We produce the raw material ourselves, so the products we offer are with high quality and reasonable and competitive ...
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Learning Center Search Results
Showing 1-5 of 5 results
England Beginning Research Series Lesson 1: Getting Started
This lesson will help you determine what you need to get started with English research. During the lesson, you will learn about the basic family history research process. You will learn about English jurisdictions, the three major record groups in England and how to utilize the websites to access records. Useful web links and printable forms are included in the lesson.
Finding Gyrid Aarsand's place of origin in Norway
To find port in Norway where Gyrid left from as well as parish in Norway where Gyrid was born.
How Do I Research Before 1837?
Tips & resources for researching family history in England & Wales pre-1837
Switzerland Research Strategies
Stuck in your Swiss research? Find out how to thoroughly analyze the records about your ancestors to find additional clues. Learn about the full information contained in birth, marriage, and death records, as well as other lesser-used record types that can help you break through your brick walls.
U.S. Hispanic Immigrants: Finding their Place of Origin
This class will give you some ideas of different record types you can use to help identify the country of origin for your Hispanic ancestor who came to the U. S. The examples used in the class are mainly for immigrants who came in the late 1800s and 1900s but the principles are applicable for those who came earlier as well.

subset: commoncrawl


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Welcome to The Six Pines where Anthea & Ray will make sure you have a very pleasant and comfortable place to stay by providing exclusive and versatile accommodation. We are situated in a quiet location just off the main street.
Our aim is for our guests to feel relaxed and at home during their stay so we will only take one booking at a time. Our accommodation is adaptable so, whilst we are happy to book only the main bedroom, we can also accommodate other member of your family or your friends, in a second bedroom. Click here for your Trip Adviser Reviews
The main bedroom is en suite and has a king size bed or twin beds.
The second bedroom as a double bed and has the exclusive use of the adjacent bathroom with shower.
All rooms have:
· Television with Freeview
· DVD and Wi-Fi access
· Tea/coffee making facilities
· Bottled water and biscuit
Breakfast is served in our cosy dining room at a mutually agreed time. There is a choice of full Scottish or Continental breakfast.
Special diets can be accommodated but please mention this at time of booking.
We welcome cyclists and walkers and provide secure cycle storage and clothes drying facilities. We can also provide packed lunches by prior arrangement.
Parking is available on the driveway.
|Double Room ensuite
|£60 Per room per night (breakfast inc.)
|Double Room Private bathroom
|£60 Per room per night (breakfast inc.)
Note: Prices are a guide only and may change on a daily basis.


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Form: Application for food business licence - Temporary food premises (Stall)
You have now accessed one of Council's online forms which are hosted through the Federal Government SmartForm Centre and the Australian Business Account (ABA) site.
If you do not have an ABA, simply select the "Open New Form" option to access the form.
If you have an ABA, select the "Login and Open Form" option. This option will enable you to store and log the transaction in your account with the log of any other government forms you have completed.
Service provided by
Website: cityofgoldcoast.com.au
Phone: 07 5667 5987
Email: firstname.lastname@example.com
Address: Council of the City of Gold Coast PO Box 5042 GOLD COAST MC 9729


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"This is a proper, old-fashioned, character-based, gag-a-minute sitcom – something UK TV's been sadly lacking of late. Indeed, with the possible exception of 'Gavin & Stacey', it's hard to think of a recent home-grown comedy that makes you laugh out loud in the way that '30 Rock' does – and with no laugh track either." - Jane Murphy, www.orange.co.uk/ entertainment/
"Most sitcoms are as bad for you as the offbrand Mexican Cheetos that Liz gorges, and as Jenna tells Liz point, employing 'a weak metaphor', you deserve a good meal. '30 Rock' is a feast." - Donald Liebenson, www.amazon.co.uk
"There's a lot of chemistry between Alec Baldwin playing Jack and Fey. I keep hoping that they'll do something between the two characters, not yet though. I'm keeping my fingers crossed that the writers work on this storyline in the future." - Julianne Jones, www.reviewstream.com
"But it's not the guest stars we're tuning in to see. The regulars all seemed to up their game in this second season. Liz Lemon is the heart of the show. Throughout the year, her struggle to keep both her career and her personal life in order was a driving force for some very funny episodes." - Robert Canning, uk.tv.ign.com
- More about:
- Alec Baldwin
- Mexico
- Sitcoms


text: Seller: auntie*que*two (10,702) 100% , Location: Constantia, New York, Ships to: Worldwide, Item: 381869126339 What a great estate find! This heating grate measures 12.5" by 18.5" and features a gorgeous design with detailed swirls and more! Great for wall hanging. Steampunk. I have a few more of these I will be listing over next few days. Check back as I am happy to combine shipping. This is quite heavy so I will ship Parcel Select to save on shipping. No reserve.Positive feedback left for every successful transaction! Check out my other items! Be sure to add me to your favorites list!


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With the superb success of Sarrainodu, Boyapati joined the list of crazy directors in Tollywood. Audience interest also raised on his next film as Sarrainodu entered 70 crore club. Unlike his usual approach of directing star heroes, he is directing young hero Bellamkonda Srinivas this time. There are reports that …Read More »
Home / Tag Archives: Boyapati next movie


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In my last column, I talked about creating your digital snowflake – and defining your large level strategy. This week, I am taking that down a notch to what to do with the content you create to reach your target audience.
If you are an editor of any sort, you are an expert at creating content that is fantastic beyond belief. The question is what is the best way, and the right order to share it with the world in a manner that showcases how valuable and fantastic your content really is?
For every piece of content you create, there are six primary distribution points you should consider and strategize around:
- Twitter. Yes, it's only 140 characters, but it reaches influencers and people who can carry your message to others they influence. Make sure you tease the content, share the content throughout the day for at least three days, and follow it up with a thank you.
- Facebook. Twitter hits one crowd, but Facebook reaches another. They are different, and the Facebook fans like content after it is released, with snippets, photos, and deals instead of advance news. Keep that in mind when you are creating your distribution strategy.
- Your website. This is a no-brainer, but the part many editors need to be reminded of is how to swap out a few words here and there to make the article more visible to others in organize search. Companies like Skyword have tools that rank "searchability" and help improve distribution and awareness a ton.
- Your content container. What is a content container? It could be anything these days – it is the main vehicle in which your content is packaged and lives. This means a print magazine, digital magazine, app, or some other format. Whatever it is, this is where the main story lives. The whole story, including access to extras that could be hosted on your site in a hidden location.
- Forums. Most often overlooked, user forums are fantastic places to share your content. The key to using content forums is that you need to do your research. Find a few that have large fans and begin a personal conversation with them. Post often and be helpful. Then, when you have content to share, others will applaud you. People like helping others out. A good forum can often beat out Facebook and Twitter in exposure as they drive passionate fans.
- A personal blog. Finally, a personal blog is a fantastic place to post your content. Your personal blog is less of a place avidly followed by millions and more of a statement about who you are. People want to see what you have done before. It helps them connect to you on a deeper level. Beginning a personal blog that is a mixture of content you publish and personal insights (that align with your content theme) will help you create a well-rounded outreach plan. And, the added bonus is, your blog can be linked to many social outlets like LinkedIn to help your content be shared on larger levels.
How many of these six distribution points are you active in? And which ones work best for you?
Related reading
Will the downfall of PewDiePie hurt YouTube, influencer marketing?
27-year-old Swede Felix Kjellberg, who goes by the name PewDiePie on YouTube, has found himself at the center of a firestorm.
How to build a successful digital video strategy in 2017
The explosive growth of video in 2016 makes 2017 an important year for video content and as more publishers are tempted to use it, it's useful to consider the best strategies to maximise its effectiveness.
Annoying requests to rate your app are getting you one star ratings. Here's how to fix that
Apple has announced that with the next update to iOS 10, they will limit the number of times an app owner can pester a user for a rating.
Bad news brands: consumers could probably live without you
Havas Group's Meaningful Brands report delivers sobering news for brands: consumers wouldn't care if 74% of the brands they use disappeared off the face of the earth.


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What to do:
-Print out this template
-Use scissors to cut it out
I love this idea! I've been considering getting my daughter a play kitchen, but space is a problem. This would work!!!ReplyDelete
What a fun idea!ReplyDelete
Thanks for leaving a comment ladies. I'm glad you liked my stove. Let me know if you end up making 1 of your own.ReplyDelete
This is totally brilliant! I am so excited about this! we don't have a playroom either (actually we do it is called the living room!) Thanks for sharing! I love this!ReplyDelete
Very cool idea! Perfect for playing and storing - best of both worlds!
Thanks for linking up today.
What a very neat idea!!!
Thanks for joining Get Your Craft on Thurs. at Life As Lori
Please join me next week for another great party!
Jenn this is truly inspired. It looks awesome! I'm going to remember this for sometime-when (^_^)ReplyDelete
I just wanted to let you know that I featured you here:
I teach preschool and my preschoolers would LOVE this! I have kitchen stuff for them to play with, but this would really be fun for them. Thank you.ReplyDelete
A really cute idea!! Love the self storage :)
Thank you so much for linking up with the Talented Tuesday link party at My Frugal Family, which is hosted every Tuesday. Please feel free to stop back in every week and post your newest projects!
What a cute idea! Thanks for submitting it to Trendy Treehouse. You are on our list to contact for featuring. Thanks again. We will contact you soon.
OMGosh!! What an ingenious idea?? You know, I've been trying to think of a good kitchen for my son that...and this ones great because of the easy clean up!! DEFINITELY going to have to blog about this one!!
BTW, please enter my giveaway for a chance to win free advertising on SuperStinkyBoys! See you!
THats pretty cute...totes CAN do more then store! hehe Thanks for linking up to Anything Related!
What a great idea! I can't wait for my daughter to get a little older so I can make her one!ReplyDelete
What a clever idea!!!! I hope you don't mind, but I would like to share your idea on my blog. Come check it out: www.kanzlerthoughts.blogspot.comReplyDelete
That is SUCH a great idea! My inlaws got DS a play kitchen for Christmas and I wish I hadn't asked for it! Between the entertainment center kitchens (which I don't have room for) and now this one, I could have done something much smaller and cuter!!! This would make a great gift, though. :)ReplyDelete
I TOTALLY love this one! What a great idea!!!
Thanks for linking at Lucky Star Lane!
Like playing with the box the gift came it, the magic of the imagination. Very cool.
That is so darn cute! I will have to keep this in mind when my youngest is a little older.ReplyDelete
I hope he's enjoying this!!
Thanks for joining Get Your Craft on Thursday! Please join me next week for another great party!
I love that. Thanks for linking up to check me out saturdays www.iamonly1woman.blogspot.comReplyDelete
We would love for you to share this at our Summer Fun Just for Kids link party!
Such a great idea! We gave away our play kitchen a few years ago due to space and my daughter growing out of it, but now I think my 14 month old son would love a stove of is own so I think this will be perfect! Thanks for sharing...ReplyDelete
After 3 kids we still don't have a play kitchen. I love this idea--so simple!ReplyDelete
What a brilliant idea, the first link I clicked on after sending you an email was this one, and it's perfect! I have been wanting to make/buy my daughter a play kitchen for ages because she loves pretending to cook, but we don't have space for anything like that. But I love this idea because it doubles as storage and when she's not interested in "cooking" anymore I can just take the stickers off and re-use the container! Brilliant!ReplyDelete
Oh my! I love this, especially as it serves as a storage container too! Brilliant!
I have started a Kids Get Crafty link up and would love for you to add this to it? (I will of course faithfully still come to yours!! ;-))
It is every Wednesday, this week here: http://www.redtedart.com/?p=3056
Thank you!
Red Ted Art
Hey there! I featured you on Bloggy Clips Thursday at Clickable Party {the blog}. See the post here and grab an "I was featured" button from the sidebar if you like!
This week's link party is here!
Clickable Party
I love this idea for my boys. I don't know how long they'll be in to the play cooking thing so I didn't want to purchase anything expensive right away. This will be great for a trial period. (Or maybe we'll just keep it forever ;) Plus it can be stored away. I know toys that get stored and then brought back out become very popular the second time around!!ReplyDelete
Tanks for the template and great idea! Nice.ReplyDelete
I am always impress with the different variations of making a kitchen for the tots! This is cute!ReplyDelete
Easy to make...and all the kitchen stuff can store inside it. Great idea!ReplyDelete
I made one of these today!!! I found a plastic tote on sale for 5.00, and had some vinyl available already. I made it similiar to your template, but not exactly the same. I found play pots and pans on sale at shopko for 13.99 and bought some mini plastic containers, spoons, and plates in the baby aisle at the dollar store. Next project is looking into some play food. May keep some small containers or such from my own kitchen. I wondered about using a similiar container standing on one end to make a fridge.. any ideas?ReplyDelete
Great Job! I really love it. Simple yet fruitful. I hope to see more next time. Thank you.ReplyDelete
Thank you for taking the time to visit my blog. I love reading comments and appreciate each and every one. Have a wonderful day & thanks for stopping by!


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FIND YOUR HOME IN Farber
Farber 63345 Real Estate
Farber is located in Missouri. Farber, Missouri 63345has a population of 407. Farber 63345 is more family-centric than the surrounding county with 36.07% of the households containing married families with children. The county average for households married with children is 33.02%.
The median household income in Farber, Missouri 63345 is $41,848. The median household income for the surrounding county is $41,387 compared to the national median of $53,046. The median age of people living in Farber 63345 is 35.3 years.
Farber Weather
The average high temperature in July is 88 degrees, with an average low temperature in January of 18 degrees. The average rainfall is approximately 39.6 inches per year, with 17.9 inches of snow per year.
Farber Map
Farber real estate offices
Real estate near Farber
Nearby Cities
Farber Zip Codes
Nearby Cities Homes for Sale


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Sonnwendhof Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Restaurant
- Multilingual staff
- Breakfast Available
- Non-smoking hotel
- Continental Breakfast
- Free High-Speed Internet
Photos of Sonnwendhof Hotel
Travelers also looked at:
- Restaurant
- Ski-in/Ski-out
- Breakfast Available
- Non-smoking hotel
- Free High-Speed Internet
- Free parking
- Pets allowed
- Family rooms
- Multilingual staff
- Continental Breakfast
TripAdvisor Reviews Sonnwendhof Hotel Semmering
Travel Blogs from Semmering
The Art of Coffee in Austria
One of my great pleasures in Austria after wandering for hours is finding a wee cafe, and having some kind of artful Austrian kaffee. This is nothing new for Europeans, Austrians, Italians, French and list goes on. The art of stopping and enjoying the moments of life rather than racing to the next activity is an art. Perhaps one that we as Canadians do not always appreciate. I know that I, for one, am pretty much on the go all the time. So, I ...
Venice to vienna
Up early. Onto water taxi for 25 mins trip to catch up with our coach. Beautiful view across to the alps which showed snow capped mountains. Prior to this while having breakfast a huge cruise ship passed our windows, very close to the shore. Quite amazing sight. Good trip out of Venice up into the alps. Lovely countryside, very green, arable, not many animals evident, but a lot of seeming pasture land. Stopped at last Italian place for morning tea, ...
On the Move
We spent most of the day travelling between Hintertux and Bruck en def Mur around 2 hours south east of Vienna. We were on buses and trains from 10:30 am to 6:00 pm but that journey look us through a valley in the Austrian Alps though numerous quaint alpine towns backdropped by some stunning views of ...
A Second Day on the Slopes
Saturday started out gray and the original forecast was for a 60% chance of precipitation. We were slow to get up, but once moving and fed everyone seemed ready to head back tot he ski slopes (except perhaps Laura, whose headache continues despite her desire to have fun and enjoy the trip).
The sun was already breaking through the clouds as we got on the highway to head to the ski area. As we had kept the rental equipment, we had no problem diverting to ...
Ow, ow, ow, ow
It was a glorious, sunny morning for our 40 minute drive up the valley to the ski area. I didn't mention yesterday that in typical fashion for us, we kind of put off making hotel reservations until pretty late, so we didn't pick a ski area so much as found a good hotel and then found the closest ski area to the hotel. Fortunately, there are hundreds in Austria, so it all worked out. Despite the fact that Google said we still had 8 kms to go, Keith still has common sense ...


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According to research recently published by Kato, a marketing and publishing consultancy specialising in the accountancy field, one in 10 of all firms is not growing but contracting. Indeed, many have decided to seek a merger or acquisition as a way out of their troubles.
About 45 per cent of the 1,200 randomly selected practices surveyed indicated that they planned to go down this road in the next three years. This is nearly three times the 17 per cent recorded by Kato's 1995 survey.
The main reasons for merger cited by the sole practitioners and partners with small and medium-sized firms who were covered by the survey, were to improve practice profitability, to achieve economies of scale, to increase specialist skills or services, to provide an exit route on retirement and to strengthen practice management and marketing.
The fact that improving profitability and achieving economies of scale - which leads to greater profitability - are at the top of the list suggests that "current levels of profit per partner are insufficient to meet expectations", says Kato.
But the consultancy is encouraged that - given the likely disruption of costs involved in combining two businesses - partners are preparing for merger or acquisition by putting emphasis on billing and collecting, and overall profitability.
Phil Shohet, director of Kato, says: "The Nineties have clearly seen a squeeze on fees, and considerable price competition on core compliance work. The better organised firms who have clearly defined strategies will continue to experience growth and be able to reinvest in staff, technology, services, marketing, premises, partners and, if relevant, specifically targeting acquisition."
As the survey indicates, while attention is focused on the one in 10 firms that is experiencing "negative growth", nearly three times as many are seeing annual growth of more than 10 per cent a year.
"Running a professional practice as a business unit is now essential if one is going to take control over one's destiny," adds Mr Shohet n
Looking for credit card or current account deals? Search hereReuse content


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Reviewer: Angel
Oh my gosh! This song has been driving me crazy for ages - like literally months and i couldn't figure out what it was or where i'd heard it! I just kept randomly outbursting the lines "i know, i know, i know" and "you cry like a baby". Today it finally got to me - i couldn't concentrate on anything so i googled those lines and FINALLY found this. Realised i'd heard it on Veronica Mars and as I type is downloading. Best/catchiest song i've ever heard....eep its ready!!!
This love isn't good unless it's me and you |
God I have always really loved this song but it's amazing when you are in this situation and it just has a whole new meaning... but my ex and I are still in love but she lives 6 hours away we are taking baby steps gettin back together she just got back from deployment and we have never stopped loving eachother but our distance gets frustrating at times I live 6 hours away and we are always driving to eachother and in a few months I'll be able to move there it's sooooo hard to be in a long distance relationship but this song truly describes us and fuck the army don't ask don't tell she's gonna be my wife someday! The line this love isn't good unless it's me and you that's my favorite it's how I feel in such few words and that's what I love about T&S their lyrics are so powerful and deep!
omg, tears! |
i cried when i heard this live, i had heard it heaps before but i never really took it on board. then i heard it live and i cried so hard. its such a cute/emotional song i just want to hug somehting when i hear it. god i love tegan and sara, keep it going girls!
Tegan and Sara r the BEST EVA!!! |
:D they're my absolute favorite for about 2 yrs in a row, now.my friends didnt like them at first because they're all i listen to, but when they finally actually gave them a chance, and listened to them, they became addicted, too!!!! :D:D:D:D xDDDD
Lovely. |
Reviewer: Her love.
Oh my goodness I could listen to them for hours. I have fallen in love with these girls. Their music isn't shallow like a lot of artists they hold powerful meaning in their lyrics complemented by such unique and beautiful voices. Gosh, they make me so happy. They are my absolute favorite. Simply amazing especially this song. It reminds of the the girl I like. Sadly she no longer even wants to be my friend. Oh well.
-Emma Lee
holy crap omg |
Reviewer: nhlfabhfalnvjkalsg
i am in love with tegan and sara music!!!!!!!!!!!! it makes me feel like .. well.. AWESOME!!! i love everyone of these songs by them and i found a pic of a guy with a tattoo that says "stick your hands in my pockets, keep them warm while i'm still here" and i screamed. i love this song. that is all i can sayy.
wow.... |
Reviewer: lovetaker
i've been in love with this song for so long but i only just looked up the lyrics...for some reason i heard "this love isn't gonna last" when they sing "this love isn't good unless." that definitely changes it!
love tegan & sara!!!!
These Chicks |
Reviewer: Jordy
Haha short time fan of these girls, im australian, no one knows them and most my friends dont like their music, but when they see parts of lyrics scribbled in my notebooks they are awestruck untill now they are fans too. Their lyrics are inspiring and i think their music is amazing, they put so much into their songs and its evident..love what they do!
Great song! |
Reviewer: Tiffany
I love this song! I didn't know about it til I saw it on youtube. Best song I've heard in a while <3
Tegan and Sarah Quin |
this song was on my now girlfrinds myspace page when I first looked at her on myspace. This song caught my ear and I now own a few of there CDs this band is totally Rockin Canada RULES!!hard to belive I missed them in cali...


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Welcome, skip to the content.
Luna Park, St Kilda
Live the life of leisure and be as busy as you please in Melbourne, choosing from a range of activities guaranteed to shake up a slow Sunday or lift a lazy public holiday.
Turn yourself upside down and inside out at Melbourne's fun parks, like the much-loved Luna Park or Wonderland Fun Park at Docklands, where the little ones can experience the thrills of a mini rollercoaster.
Head to PLAYTIME Crown will for an indoor world of amusements, laser skirmish, bowling and motion rides. Test your skill at GlowGolf in Docklands: mini golf with a twist.
Join your mates for a go-kart race close to the city centre, or get your ice skates on at O'Brien Group Arena. If the great outdoors calls you, head to Melbourne's parks and beaches for boating, kiteboarding, or some old-fashioned beach cricket.
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24 Feb 2017
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Following a hugely popular season last summer, QV Melbourne's Outdoor Cinema returns on 30 November with another program full of Melbourne's...
Sports and movie fans will again have an opportunity to sit back on the hallowed MCG turf and enjoy a movie in one of the world's most spectacular...
A playful reinvention of the suburban car wash is the concept behind the 2016 NGV Architecture Commission built in the NGV's Grollo Equiset Garden...
Ahoy there me hearties. Come aboard the tall ship, Polly Woodside on the first Sunday of each month for a pirate Sunday. The first treasure kicks off...
Moomba is back again with an exciting program of free events and family entertainment.
The Victoria Street Lunar Festival has become one of the most popular and recognised Lunar New Year celebrations in Victoria, drawing people from all...
Virtual Reality is the new buzzword, and That VR Joint has tons of tech to let you experience all that this amazing technology is capable of. There...
Wyncity Bowl and Entertainment is Australia's premier family entertainment centre. Located in Point Cook, Melbourne, Wyncity excels at exceeding your...
Who says bowls are only for seniors? Fitzroy Bowls Club bring bowls players young and old to the greens, and serve cheap beer and meals to boot.
Join the hordes of lap swimmers and laid-back locals at this 50m heated outdoor pool in Fitzroy, where DJs hit the decks on summer Sunday afternoons.
Swim back in time as you do your laps at these historic public baths. This modern 30-metre indoor heated lap pool is housed in a beautiful Federation building.
Channel your inner champion at Melbourne's biggest aquatic centre, complete with lap pools, diving boards, an enormous water slide and wave pool.
There's plenty of things to do for the whole family in Melbourne from interactive museums and kids' festivals to zoos and wildlife parks.
Explore Melbourne on foot with an expert walking guide, join a bus tour or follow the historic City Circle Tram route on a tour of the city's cafes.
Make the most of the rivers, parks and coastline Melbourne has to offer with a range of outdoor activities to suit your interests and lifestyle.
Melbourne is a melting pot of cultures, a fact reflected in its restaurants, cafes, bistros and bars. Feast on a dizzying spread of the world's great cuisines.


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Top Definition
more extreme version of OMG; expressing extreme emotions such as Happiness, Sadness, Anger, etc.
John: Bro did that bitch take a shit on your X-Box?
Brennen: USHER OMG!
Brennen: USHER OMG!
by BuddhasBlunt420 August 18, 2011
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


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Opening times for 93 Feet East
Location map of 93 Feet East
Underground Stations
Railway Stations
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Hotels Near
93 Feet East
What's On Today
Near 93 Feet East
AJ Tracey
Clubbing and Nightlife | Until 23rd February 2017
XOYO 1.87 miles from 93 Feet East
The grime artist from London performs in support of his EP Lil Tracey....More
The Yonce Experience
Clubbing and Nightlife | On 22nd February 2017
XOYO 1.87 miles from 93 Feet East
Martin2smoove, SWYR and Andy P supply all things Beyonce and Destiny's Child, so get ready to shake that booty....More
Electric Wednesday
Clubbing and Nightlife | Until 26th July 2017
Club Aquarium 1.88 miles from 93 Feet East
Francesco Poggi, CASSIMM and a host of weekly guests spin house and techno all night long....More
Kick Out The Jams
Clubbing and Nightlife | On 22nd February 2017
The Queen Of Hoxton 1.93 miles from 93 Feet East
Embark on a musical journey as DJs explore their vast physical and digital collections. Expect disco, soul, funk and reggae....More
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Clubbing and Nightlife | Until 7th April 2017
The Queen Of Hoxton 1.93 miles from 93 Feet East
On the back of its popular A Tribute to Dr. Strange summer residency, the Queen of Hoxton's rooftop is set ...More
Sorry, I Killed Your Cat
Theatre | Until 25th February 2017
The Courtyard Theatre 2 miles from 93 Feet East
Morrissey And Marshall
Concerts | On 22nd February 2017
The Old Blue Last 2.03 miles from 93 Feet East
The Dublin-based pairing performs its self-penned soft rock material....More
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Village Underground 2.09 miles from 93 Feet East
The Texan four-piece play synth-heavy alternative rock....More
Fried Sugar
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Cargo 2.12 miles from 93 Feet East
The finest resident DJs spin hip hop and R&B each week....More
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Shoreditch Town Hall 2.12 miles from 93 Feet East
Jamie Lloyd directs Philip Ridley's darkly comic collection of new monologues, starring John MacMillan....More
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Matthew Carver's The Cheese Truck takes up permanent residence in the historic Camden Stables as The Cheese Bar....More
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Henrietta Hotel
The first London hotel from team behind the Experimental Cocktail Bar has 18 rooms and a restaurant by top chef Ollie Dabbous....More
The Craft of Film
Film Events | Until 28th February
Taking place in the midst of award season, The Craft of Film at the Barbican ...More
Cut Festival: The Art of Barbering
Exhibitions | From 5th March
A ten-day event, the Cut Festival brings together ...More
The Future Of Fashion Weekend
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The Future of Fashion Weekend at the House ...More
Tim Burton All-Nighter
Film Events | On 25th February
The Prince Charles Cinema pays homage to Tim Burton this weekend with an all-nighter dedicated ...More
Catalan cuisine from Victor Garvey served in a dining room reminiscent of Barcelona's elegant-but-casual beachfront ...More
An approachable, unpretentious menu, based on international tapas-style dishes, is served in the colourful, comfortable ...More
The Italian Bookshop
Whether you're an Italian living in London or interested in learning the language, the Italian Bookshop has something to offer....More
European Bookshop
Well stocked bookshop selling books for European languages and literature, serving Londoners since 1964....More
Aurelie Altemaire, formerly Head Chef at Michelin-starred L'Atelier de Jöel Robuchon, has created a modern ...More
Chai Thali Indian Street Food Bar & Restaurant
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Number 177 Bar Official Launch
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Party tunes from Andy Blake, Carlo Anderson, Elena Colombi, Hannah Holland, Jef K, Jess Farley, Josh Caffe, Medlar, Nicola Cima, Nostalgia of Mothership, Ross From Friends, Sami Daik, ...More
4MationZone Presents: Extractions
Concerts | On 10th March
Forward thinking electronic musicâ¨â¨....More
The Tickled Bean Comedy Club
Comedy | Until 16th March
Comedy, Musical....More
Gente de Cuba by Isabella Palumbo
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A collection of street portraits made during Isabella ...More
Hair The Musical
Theatre | From 3rd December
Celebrating its 50th year, Hair comes to London this year. The acclaimed musical will be ...More
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Funk and acid jazz outfit, fronted by lead singer Jay Kay, perform works from their ...More
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Imelda Staunton stars in two London stage shows in 2017, David Tennant and Damian Lewis ...More
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text:
The Movie Quotes Test
Their result for The Movie Quotes Test ...
You scored 90 in the category of movie geekiness!
Their Analysis (Vertical line = Average)
They scored 90% on movie geekiness, higher than 90% of your peers.
All possible test results
80%-100%--Congratulations! You're a true movie geek! If there were an awared for Most Hours Spent Sitting On The Couch, you deserve it! 60%-79%--Good job! When it comes to movies, you're decidely ge... Read more
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Is Rollo S Great Outdoors Centre incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog NewZealand provides information regarding Rollo S Great Outdoors Centre in Nelson. Rollo S Great Outdoors Centre is located at 12 Bridge Street, Nelson Nelson 7010 and provides Clothing services. Contact them on 03-548 1975 or by visiting them on their website http://www.rollos.co.nz/.
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Mon-Fri 9:00-17:30; Sat 9:00-15:00
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17 Brook Street Nelson Nelson 7010
31 Bolt Road Tahunanui Nelson 7011
14 Parere Street Nelson 7010
Suite 2 134 Bridge Street Nelson 7001
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Member Since: 09/18/07Send charleneswain a Message Give charleneswain a Gift Add charleneswain as a Friend
Beautiful Kind Friendly Loving Very Attractive Friend One of a Kind Determined Hardworking Talented Motivated
You can reach this milestone by accruing more than 50 reputation points in the last 7 days
You can reach this milestone by completing the quiz Who's Your Inner Nurse?
You can reach this milestone by completing the quiz What's Your Perfect Nursing Career Fit?
You can reach this milestone by starting a group that is one of the top 100 most active groups.
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- Friday
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Add charleneswain as a friend to write on their Comment Wall.
"If ever there is tomorrow when we're not together... there is
something you must always remember. You are braver than you
believe, stronger than you seem, and smarter than you think.
But the most important thing is, even if we're apart... I'll
always be with you."
When the Lord made Nurses...
He was in his sixth day of overtime when an angel appeared and said " You're doing alot of fiddling around on this one."
And the Lord said, " Have you read the specs on this order? "
" A Nurse has to be able to help an injured person, breathe life into a dying person, give comfort to a family that has lost their only child, and not wrinkle their uniform.
They have to be able to lift 3 times their own weight, work 12 to 16 hours straight without missing a detail, and console a grieving mother as they are doing CPR on a baby they know will never breathe again...
They have to be in top mental condition at all times, running on too-little sleep, black coffee and half-eaten meals. And they have to have six pairs of hands. "
The Angel shook her head slowly and said,
" six pairs of hands..no way"
"It's not the hands that are causing me the problems," said the Lord, " It's the two pairs of eyes a Nurse has to have." "That's on the standard model?" asked the angel.
The Lord nodded. " One pair that does quick glances while making note of any physical changes, and another pair of eyes that can look reassuringly at a bleeding patient and say,"You'll be all right, Ma'am." when they know it isn't so."
"Lord," said the angel, touching his sleeve, "rest and work on this tomorrow."
" I can't," said the Lord, " I already have a model that can talk to a 250 pound grieving family member whose child has been hit by a drunk driver...who, by the way, is in the next room uninjured..and also be able to feed a family of five on a Nurse's paycheck."
The angel circled the model of the Nurse very slowly.
"Can it think?" she asked. "You bet," said the Lord," It can tell you the symptoms of 100 illnesses; recite drug calculations in its' sleep; intubate,defibrillate,medicate, and continue CPR nonstop until help arrives...and still keep its' sense of humor.
This Nurse also has phenomenal personal control.They can deal with a multi-victim trauma, coax a frightened elderly person to unlock thier door, comfort a murder victim's family, and then read in the daily paper how nurses are insensitive and uncaring and are only doing a job."
Finally, the angel bent over and ran her finger across the cheek of the nurse. " There's a leak." she pronounced. "I told you that you were trying to put too much into this model."
"That's not a leak," said the Lord, "It's a tear."
"What is the tear for?" asked the angel.
"It's for bottled-up emotions, for patients they've tried in vain to save, for commitment to that hope that they will make a difference in a person's chance to survive, for life"
"You're a genius" said the angel.
The Lord looked somber...." I didn't put it there" He said.
Great news. Christian John Godfrey (my new grandson) was born this morning at 6:07 am, vaginally, with the help of an epidural. The L&D nurse could have been better at the time of delivery (much, much better), but the nurses afterward made up for a lot. He was 20.5 inches and 7 lbs 13 oz.
(We are friends with director of the place [Nurse-Midwife], so that will not happen to anyone else.)
He is adorable. Quiet. Only cried when taken from our warm, cuddly arms to have a bath. My son was horsing around with him (the 32 year old bachelor uncle) and Christian suddenly had a cute little smile and he ripped a loud one and filled his diaper.
My wife and I are trying to catch-up with sleep the rest of today. Tomorrow, we have friends coming over to help clean up tomorrow, so that my daughter and family do not have to stay in the motorhome in the backyard (that's not too bad, 34' Winnebago).
Will attach pictures when I get everything transferred.
Thank you for your well wishes and prayers.
Hope all is going well with you.
SUPER BUSY here. Daughter's 1st wedding anniversary today, baby is due in 7 days, just had electrician in for 2 days doing work (and he isn't finished yet), then I have to get my family to move all of the furniture to the corner of the rooms (every room), because tomorrow we start getting energy efficient windows installed to the entire house at once. In other words, I am surprized to have gotten this much time to play on the Internet :-)
I just had the electrician in doing a lot of re-wiring and up-grading of wires. Our house was build with "knob and tube wiring" Very old and can cause fires. Especially when accepting the loads that we put on them now.
So my bedroom alone, went from 9 old plugs, to 4-quads (16 plugs) and a single (18 plugs altogether.) With a/c, computers, rechargers, lamps, etc, etc. I figured that dropping $1200 into a good electric guy was much better than the pain and inconveinance of having my house burn down.
My daughter has appreciated it when I have re-positioned Christian a few times because he was on a nerve, or worse. She called me to her room one night and Christian was stretching from side-to-side and Ashley was nearly in tears. I oriented myself to Christian's positioning and rotated him back to a heads-down position. My daughter looked at me like I performed a miricale (it was then that I realized how bad she had really been hurting). They slept for the night.
All of this nursing and medical training hasn't gone totally to waste. I cared for pets before they died and can re-position the baby when needed (who knows, I might even deliver this baby, the way things are going).
Have a great week.


text:
Does this attraction require above average amounts of physical activity (long walks, climbs, stairs or hikes)?
Does this attraction have good sunset views?
Does this attraction have good scenic or skyline views?
Is this attraction pet friendly?
Does this attraction provide visitors with a taste of the local culture?
Is this attraction exciting, unusual, or risky to visit?
Is this attraction good for couples?
Is this attraction suitable for all ages?
Would this be a good sunny day activity?
Would this be a good hot day activity?
Thanks for helping!
Well maintained, paved foot path around part of lake, several hiking trails from easy and moderate. Small visitors center with friendly staff. No picnic areas, no dogs and jogging...
read more
3 Days in Nashville
Museum Guide for Nashville
One Day In Nashville
Well maintained, paved foot path around part of lake, several hiking trails from easy and moderate. Small visitors center with friendly staff. No picnic areas, no dogs and jogging on trails kept this review from a 5.
Although it was hard to get a parking space because the weather was beautiful it was well worth it. Love stopping here when we are in Nashville.
Easy to access, well kept trails and variable levels of hiking are all part of the Radnor experience. Only complaint is the lack of parking in the evenings or weekends
Radnor Lake is a State Natural Area that consists of trails that wonder around a lake and through the hills. Great hiking. Try the Garner Ridge and Lake Trail which is about 3.0 miles total. If you go on a Saturday go early because of limited parking. The only drawback to Radnor is the parking during busy times. Give it...
We hiked here on Black Friday instead of shopping. The fall foliage was gorgeous and the trails are very well maintained. The only problem was the very, very limited parking. Get there early or you have to wait in line until a space opens up. Loved this park!
Loved the longer hike up the hills! We went on a gorgeous day in early November. The line to enter was surprisingly long, I've never had to wait to park at a park before. The park rangers were on hand with radios though to assist all the cars. I think some people parked outside of the entrance, at a nearby...
Very nice trails through the woods. Quiet and tranquil escape from the city. Lots of wildlife, including an owl, deer, turtles. Beautiful views of the lake, little waterfalls, and bluffs.
Well, just moved here to Nashville and had some time on my hands thought I would check out the local parks. I went here, parked, went to the entrance, greeted with a sign that said:
No running
No Drinking
No Eating
No Dogs
No Jogging
I think I have a picture of it somewhere, it was hysterical. It was like...
I have been going here since I was in high school and it has changed drastically over the years. For those who live in the city, this is a convenient place to get out in nature. The trails around the lake are an easy hike and handicapped accessible. It is a popular place for new moms with exercise strollers, local...
Radnor lake has some nice trails and good scenery. The trail around the lake is paved and not too hilly. The ridge top trail is a nice hike. Parking is sometimes limited and not easy to find.
Is there any mean of transportation from downtown to the State Park (and back)?
Can we drive through the park?
Will the park be open on Thanksgiving Day?
Does the Music City Bikeway connect to the park?
Would swimming be permitted in the lake?
See all questions


text:
Following 36 Tea Drinkers
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Tea drinker, blogger, bi-vocational clergy, reader and walker. Madly, passion...
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 21, 2006
|Filing date
|Apr 30, 2003
|Priority date
|Apr 30, 2003
|Fee status
|Also published as
|Publication number
|Wayne Arthur Noda
|Original Assignee
|Alsius Corporation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (13), Referenced by (13), Classifications (8), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates generally to intravascular heat exchange catheters.
Intravascular catheters have been introduced for controlling patient temperature. Typically, a coolant such as saline is circulated through an intravascular heat exchange catheter, which is positioned in the patient's bloodstream, to cool or heat the blood as appropriate for the patient's condition. The coolant is warmed or cooled by a computer-controlled heat exchanger that is external to the patient and that is in fluid communication with the catheter.
For example, intravascular heat exchange catheters can be used to combat potentially harmful fever in patients suffering from neurological and cardiac conditions such as stroke, subarachnoid hemorrhage, intracerebral hemorrhage, cardiac arrest, and acute myocardial infarction, or to induce therapeutic hypothermia in such patients. Further, such catheters can be used to rewarm patients after, e.g., cardiac surgery or for other reasons. Intravascular catheters afford advantages over external methods of cooling and warming, including more precise temperature control and more convenience on the part of medical personnel.
The following U.S. patents, all of which are incorporated herein by reference, disclose various intravascular catheters/systems/methods: U.S. Pat. Nos. 6,419,643, 6,416,533, 6,409,747, 6,405,080, 6,393,320, 6,368,304, 6,338,727, 6,299,599, 6,290,717, 6,287,326, 6,165,207, 6,149,670, 6,146,411, 6,126,684, 6,306,161, 6,264,679, 6,231,594, 6,149,676, 6,149,673, 6,110,168, 5,989,238, 5,879,329, 5,837,003, 6,383,210, 6,379,378, 6,364,899, 6,325,818, 6,312,452, 6,261,312, 6,254,626, 6,251,130, 6,251,129, 6,245,095, 6,238,428, 6,235,048, 6,231,595, 6,224,624, 6,149,677, 6,096,068, 6,042,559.
As recognized by the present invention, condensation can accumulate on the fluid lines (typically IV tubes) that carry cold circulating coolant between the catheter and heat exchanger. This condensation is undesirable because it can lead to messy dripping water near the patient or onto electrical equipment. Furthermore, heat is exchanged with the coolant as it flows through the lines. This means that the lines represent an undesirable parasitic heat load (adding heat to the coolant) when the coolant is desired to be as cold as possible. On the other hand, when it is desired to warm a patient, the coolant when hotter than room temperature will undesirably lose heat as it flows through the lines. Having recognized these problems, the solution below is provided.
A system for establishing human patient temperature includes a heat exchange catheter configured for placement in the patient to exchange heat therewith when coolant is circulated through the catheter, and a heat exchanger supplying coolant to the catheter and receiving coolant from the catheter in a closed circuit. The closed circuit includes at least one thermally insulated coolant line.
In a preferred embodiment, the thermally insulated coolant line includes an inner tube forming a lumen for carrying coolant and an outer insulating tube, with the inner tube being closely received in the outer insulating tube such that no space exists between the tubes. The inner tube can be made of IV tubing and the outer tube can be made of closed-cell foam or a metallic foil-like material.
In an alternate preferred embodiment, the coolant line includes an inner tube forming a coolant-carrying lumen and an outer tube surrounding the inner tube and spaced therefrom by webs that connect the inner tube to the outer tube such that at least one insulative dead air pocket is formed between the inner and outer tubes. The inner tube, outer tube, and web can be made of a single unitary structure, or the outer tube can be made of a separate structure than the inner tube.
In another alternate embodiment, the coolant line includes an inner tube forming a coolant-carrying lumen and a substantially incompressible spacer on an outer surface of the inner tube. An outer tube surrounds the spacer such that at least one dead air pocket is established between the tubes. The spacer may be a helically configured monofilament. If desired, the dead air pocket can have proximal and distal ends that are sealed.
In another aspect, a method for treating a patient includes providing a heat exchanger, and advancing a heat exchange catheter into the patient. The catheter communicates with the heat exchanger. The method also includes circulating coolant between the heat exchanger and catheter such that heat is exchanged between the catheter and patient without infusing coolant into the bloodstream of the patient. At least one coolant line between the catheter and heat exchanger is thermally insulated.
In still another aspect, in a system including a heat exchanger, an intravascular closed loop heat exchange catheter, and at least one coolant line connecting the heat exchanger to the catheter, means are provided for insulating the coolant line.
The details of the present invention, both as to its structure and operation, can best be understood in reference to the accompanying drawings, in which like reference numerals refer to like parts, and in which:
Referring initially to
Additionally, the catheter 18 includes a guide wire and primary infusion tube 32 that terminates in a fitting such as a female Luer 34. A guide wire 36 can be advanced through the tube 32 in accordance with central venous catheter placement principles, or medicament or other fluid can be infused through the guide wire and primary infusion tube 32. Moreover, a secondary infusion tube 38 with female Luer fitting 40 can be selectively engaged with a medicament source 42 for infusing fluid from the source 42 through the secondary tube 38.
As discussed further below, the tubes 20, 24, 32, 38 are held in a distally-tapered connector manifold 44. As also set forth further below, the connector manifold 44 establishes respective pathways for fluid communication between the tubes 20, 24, 32, 38 and respective lumens in a catheter body 46.
A suture anchor 48 advantageously is formed on the connector manifold 44 for suturing the catheter 18 to a patient in accordance with central venous catheter operating principles. In one intended environment, the suture anchor 48 includes opposed ears 50 formed with respective suture holes 52. Other equivalent anchor structure can be used to hold the catheter 18 onto the patient, however, including surgical tape. When the catheter is a so-called Swan-Ganz catheter, i.e., a catheter of the type disclosed in U.S. Pat. No. 3,995,623, incorporated herein by reference, the anchor 48 typically would not be provided.
The catheter body 46 may include at least two lumens, and in the preferred embodiment the catheter body 46 includes at least four lumens. More specifically, the catheter body 46 can define a coolant supply lumen, a coolant return lumen, a guide wire lumen, and a secondary infusion lumen. A lumen can also be provided for holding a wire or wires that are attached to one or more distally-located sensors, such as temperature sensors, pressure sensors, gas sensors, and electrical sensors.
In any case, the connector manifold 44 establishes a pathway for fluid communication between the coolant supply tube 20 and the coolant supply lumen of the catheter. Likewise, the connector manifold 44 establishes a pathway for fluid communication between the coolant return tube 24 and the coolant return lumen. Further, the connector manifold 44 establishes a pathway for fluid communication between the guide wire and primary infusion tube 32, and the guide wire lumen, which can terminate at an open distal hole 62 defined by a distally tapered and chamfered distal tip 63 of the catheter body 46. Also, the connector manifold 44 establishes a pathway for fluid communication between the secondary infusion tube 38 and the secondary infusion lumen, which can terminate at an infusion port 64 in a distal segment of the catheter body 46. Additional ports can be provided along the length of the catheter.
The catheter 18 has a distally-located heat exchange member for effecting heat exchange with blood as it flows past the catheter when the catheter is positioned in the vasculature of a patient. The heat exchange member can be any of the heat exchange members disclosed in the above-referenced patents. By way of example, the preferred non-limiting catheter shown in
The heat exchange membranes 66, 68 can be inflated with coolant from the coolant source 12 as supplied from the coolant supply lumen, and coolant from the heat exchange membranes 66, 68 is returned via the coolant return lumen to the coolant source 12. In their inflated configurations, the heat exchange membranes define a diameter of about ten French, and preferably no more than twelve French. Thus, the heat exchange membranes 66, 68 are relatively long and comparatively thin, to advantageously avoid excessively blocking blood flow through the vena cava while nevertheless effecting patient cooling.
If desired, a temperature sensor 70 such as a thermistor or other suitable device can be attached to the catheter 18 as shown. The sensor 70 can be mounted on the catheter 18 by solvent bonding at a point that is proximal to the membranes 66, 68. Or, the sensor 70 can be disposed in a lumen of the catheter 18, or attached to a wire that is disposed in a lumen of the catheter 18, with the sensor hanging outside the catheter 18. Alternatively, a separate temperature probe can be used, such as the esophageal probe disclosed in U.S. Pat. No. 6,290,717, incorporated herein by reference. As yet another alternative, a rectal probe or tympanic temperature sensor can be used. In any case, the sensor is electrically connected to the coolant source 12 for control of the temperature of the coolant as described in various of the above-referenced patents.
As envisioned by the present invention, the structure set forth above can be used in many medical applications to cool a patient and/or to maintain temperature in a normothermic or hypothermic patient, for purposes of improving the medical outcomes of patients on whom, e.g., aneurysm surgery is to be performed, preferably while the patient's temperature is below normal body temperature. The structure can then be used to rewarm the patient in a controlled manner by circulating warm coolant through the structure, or by otherwise regulating natural body rewarming by circulating coolant that is maintained at an appropriate cool (relative to normal body temperature) or warm (relative to normal body temperature) temperature through the structure.
As another example, head trauma and/or stroke can be treated by and after lowering and maintaining the patient's temperature below normal body temperature. Or, cardiac arrest can be treated while the patient's temperature is below normal body temperature. Yet again, minimally invasive heart surgery can be performed on the patient while the patient's temperature is below normal body temperature. And, myocardial infarction in the patient can be treated while the patient's temperature is below normal body temperature. Also, the present invention understands that for certain patients, e.g., stroke victims, it is important to maintain the temperature of a patient at or below normal body temperature, when the patient runs or attempts to run a fever. For severe ischemic stroke victims, the malady can be treated by maintaining the patients body temperature at a hypothermic level.
Now referring to
In contrast,
While the particular INTRAVASCULAR HEAT EXCHANGE CATHETER WITH INSULATED COOLANT TUBES as herein shown and described in detail is fully capable of attaining the above-described objects of the invention, it is to be understood that it is the presently preferred embodiment of the present invention and is thus representative of the subject matter which is broadly contemplated by the present invention, that the scope of the present invention fully encompasses other embodiments which may become obvious to those skilled in the art, and that the scope of the present invention is accordingly to be limited by nothing other than the appended claims, in which reference to an element in the singular is not intended to mean "one and only one" unless explicitly so stated, but rather "one or more". All structural and functional equivalents to the elements of the above-described preferred embodiment that are known or later come to be known to those of ordinary skill in the art are expressly incorporated herein by reference and are intended to be encompassed by the present claims. Moreover, it is not necessary for a device or method to address each and every problem sought to be solved by the present invention, for it to be encompassed by the present claims. Furthermore, no element, component, or method step in the present disclosure is intended to be dedicated to the public regardless of whether the element, component, or method step is explicitly recited in the claims. No claim element herein is to be construed under the provisions of 35 U.S.C. �112, sixth paragraph, unless the element is expressly recited using the phrase "means for".
|Cited Patent
|Filing date
|Publication date
|Apr 29, 1975
|Jul 27, 1976
|Erbe Elektromedizin Kg
|Cryogenic surgical instrument
|Apr 18, 1977
|Sep 5, 1978
|Datascope Corporation
|Topical hypothermia apparatus and method for treating the human body and the like
|Dec 11, 1987
|Nov 21, 1989
|The Yokohama Rubber Co., Ltd.
|Hose for transport of refrigerant fluids and fuel oils
|Feb 10, 1989
|May 5, 1992
|The Research Foundation Of State University Of New York
|Method for hypothermic organ protection during organ retrieval
|Jul 8, 1993
|Mar 28, 1995
|Cryomedical Sciences, Inc.
|Cryogenic transport hose
|Jul 6, 1994
|Sep 26, 1995
|Apd Cryogenics, Inc.
|Feb 22, 1995
|Jul 8, 1997
|Seabrook Medical Systems, Inc.
|Cold therapy system with intermittent fluid pumping for temperature control
|Aug 6, 1998
|May 9, 2000
|Friedman; David J.
|Coded intravenous tubing
|May 7, 1999
|Nov 21, 2000
|Innercool Therapies, Inc.
|Circulating fluid hypothermia method
|Mar 15, 2000
|Apr 30, 2002
|Gary M. Onik
|Combined electrosurgical-cryosurgical instrument
|Dec 16, 2002
|Jul 24, 2003
|Dobak John D.
|Isolated selective organ cooling method
|May 31, 2002
|Dec 4, 2003
|Vahid Saadat
|Apparatus and methods for cooling a region within the body
|Title not available
|Citing Patent
|Filing date
|Publication date
|Apr 4, 2008
|Jan 24, 2012
|Velomedix, Inc.
|Automated therapy system and method
|Jul 8, 2008
|May 14, 2013
|Velomedix, Inc.
|Hypothermia devices and methods
|Jan 19, 2012
|Jul 9, 2013
|Velomedix, Inc.
|Automated therapy system and method
|Oct 23, 2006
|Mar 18, 2014
|Velomedix, Inc.
|Method and apparatus for peritoneal hypothermia and/or resuscitation
|Oct 17, 2012
|Jan 26, 2016
|Zoll Circulation, Inc.
|Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops
|Oct 23, 2006
|May 10, 2007
|Ceeben Systems, Inc.
|Method and apparatus for peritoneal hypothermia and/or resuscitation
|Mar 21, 2006
|Sep 27, 2007
|Nidus Medical, Llc
|Apparatus and methods for altering temperature in a region within the body
|Jul 8, 2008
|Mar 19, 2009
|Daniel Rogers Burnett
|Hypothermia Devices and Methods
|Nov 9, 2009
|May 13, 2010
|Daniel Rogers Burnett
|Devices and Methods for Monitoring Core Temperature and an Intraperitoneal Parameter
|Feb 8, 2010
|Aug 12, 2010
|Hall Gregory W
|Method and Apparatus for Inducing Therapeutic Hypothermia
|Oct 29, 2010
|Feb 24, 2011
|Mantle Ross E
|Device for the Extravascular Recirculation of Liquid in Body Cavities
|May 29, 2009
|Apr 28, 2011
|Medtronic ,Inc.
|Lead extension having connector configured to receive two leads
|Oct 17, 2012
|Apr 3, 2014
|Zoll Circulation, Inc.
|Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops
|U.S. Classification
|607/105, 607/104
|International Classification
|Cooperative Classification
|European Classification
|Apr 30, 2003
Owner name: ALSIUS CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:NODA, WAYNE ARTHUR;REEL/FRAME:014031/0259
Effective date: 20030428
|Aug 21, 2009
|Fee payment
Year of fee payment: 4
|Aug 29, 2009
Owner name: ZOLL CIRCULATION, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ALSIUS CORPORATION;ALSIUS MEDICAL CORPORATION;REEL/FRAME:023163/0419
Effective date: 20090504
|Mar 14, 2013
|Fee payment
Year of fee payment: 8


text:
Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Cichlids (http://www.tropicalfishkeeping.com/cichlids/)
- - What Would Be a Good South American Cichlid to Stick In..... (http://www.tropicalfishkeeping.com/cichlids/what-would-good-south-american-cichlid-12795/)
What Would Be a Good South American Cichlid to Stick In.....
I have a 29 gallon im going to redoas soon as i get rid of the pleco and Yellow Lab and id like to stick a single decent looking fish in it... I like Green Terror's and Jack Dempsey's but they get to big. So what would u pick for this?[/u]
Re: What Would Be a Good South American Cichlid to Stick In.
ok i figured out what im gona do insted so... its either 29 gallon dwarf puffer tank... (i doubt to few decorations and on a budget)... or combining 2 similar 10 gallons into it and then DP's in one of the ten gallons.
I put 2 apistos in my 29, then added a couple more tetras (against my better judgement) and boom, the apistos spawned :O so far only once but talk about over stocked now lol I need to give away some apistos to the LFS so my ammonia doesnt keep going up... I only have 1 penguin 200 on there.
as for the rest, my glowlights, red eyes, and cories, they are entirely entertaining to watch.
id get a pair of firemouths personally.
oooh i like gage's suggestion better :D might get a bit tight, but if its just the 2 firemouths than that would be gorgeous!
Keyholes, Rams, any Apistos, Killifish are pretty or even a pair of Paradise fish. I'd go with a pair Apistos and some tetras.
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text:
Reviewed By James M (Chittenango, NY) Reviewed for a 2006 Chevy Monte Carlo —6/15/2013 5:32 PM
Great product. Looks great & easy to install
Reviewed By Robert H (Warren, MI) Reviewed for a 2004 Chevy Monte Carlo —4/30/2011 8:10 PM
Wow! Great sound. Did a lot of research about mufflers. Placed a call to Flowmaster and told them what I wanted. They were very helpful when I told them what I wanted. They recommended the series 40 for an aggresive sound. Autoanything was helpful also in my decision. Autoanything was prompt on delivery and the price was the best I found after doing much research about pricing.


text:
Yep that's all I use.
Yep that's all I use.
Is scanning the USB OTG a possibility? I just picked up a 128GB flash drive and a USB OTG cable. When it's hooked up I can go to the directory and choose USB OTG but there doesn't seem to be an option to scan it in. It's nice to have 192GB of music at your fingers though.
From what I know, no you cannot... the workaround I've come up with is to organize the music I intend to use on the DX50 differently, and put it in just a few folders (I usually use an Artis==>Album folder structure), with all songs together. Then I navigate Directory==>OTG==>folder, select a song, and the DX50 scans the ENTIRE folder and adds it to its database (doing this for every Artist==>Album folder would get old VERY fast, which is why I do things differently for what I want to use on the DX50 through OTG). On the 32GB microSD card I connect through OTG I use just 2 folders, so it's not a big deal... it takes a little time to scan each folder (there's about 400 songs in each), but then it knows them and you don't need to scan again (as long as you start the DX50 with the scanned OTG "whatever" connected... if you start the DX50 without it, it will realize that the OTG music is not there, and will delete it from the database, which means that next time you will have to, again, navigate to the folder to add it to the database). All this because I like to listen to a big collection on random... if, on the other hand, you want to select a specific album, it's better to organize everything by an Artist===>Album folder structure and simply navigate to the proper folder.
Yep that's what I've been doing.
hI all lucky dx50 owners
pLease post your impressions if you have tryed with akg k3003
nevermind .. I saw that the Genre file sort issue was mentioned in post 2992 ...
Ummm, someone also commented on this previously. It turns out he was literally trying to pull out the card, which is not the proper way to release it. You have to push the card in the slot to release it and a spring mechanism pushes it out of the slot. This is pretty much standard for card slots. FYI, if you are doing the same thing.
Hi. I'll be new dx50 owner.
I have a question, can I use the amp or no amp for this dap.
what kind of sd card do you use?
Mine was picked up in Shenzhen at 20:22 on Sept 28. DHL tracking indicates that it is with the delivery courier in Canada at 14:51 on October 1.
Correction. Just Arrived with $15.00 due. Those DHL folkss are fast.


text:
Singularity – Robot Anthology
A few months ago I was lamenting that there did not appear to be anyone making a robot anthology. Robots are a concept that is very near and dear to my heart. I find so many things interesting about robotics that I have a billion different story and illustration ideas swirling in my head. So many that I don't think I'll ever have time to get to all of them. I'm forcing restraint by not delving into my adoration further.
I've often heard that if there is content you want to see, you should make it. Sure, but I didn't want to be the only person making robot comics and art. I presented the idea of a robot anthology on twitter and was surprised by how many people responded positively. While the notion of making an anthology was daunting, I wanted it to exist so badly.
Slowly but surely, I started to make timelines, running ideas past friends, writing guidelines, saving up money, contacting artists, and overall bracing myself. If no one else was going to make my idea I was.
After many months of a lot of work both by myself and others, I'm happy to present Singularity: A Robot Fanzine. Well, it's technically two zines, one to house all of the all ages content (contraption) and one for the *ahem* adult content (convergence)
This is the first anthology I have ever put together as an editor/art director. And boy was it a learning experience. I mean that in the absolute best way possible. So many amazing and talented artists worked so hard to make this possible. I seriously cannot be happier. I even made a nine page comic for Convergence.
Both zines are available now for digital purchase on itch.io. Contributing artists get a cut of all digital sales.Read More »


text:
Is Ray-Control Services incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Singapore provides information regarding Ray-Control Services in Singapore. Ray-Control Services is located at Blk 2 Bukit Batok St 24 #02-10, Singapore 659480 and provides Repair Services services. Contact them on 6563 0544.
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text:
Successful Memory Techniques In A Week How to Improve Memory In Seven Simple StepsBy: Cheryl Buggy (author), Jonathan Hancock (author)eBook
An effective memory is crucial to anyone who wants to advance their career.
Written by Jonathan Hancock and Cheryl Buggy, leading international memory experts, this book quickly teaches you the insider secrets you need to know to in order to recall whatever you need to in the workplace.
The highly motivational 'in a week' structure of the book provides seven straightforward chapters explaining the key points, and at the end there are optional questions to ensure you have taken it all in. There are also cartoons and diagrams throughout, to help make this book a more enjoyable and effective learning experience.
So what are you waiting for? Let this book put you on the fast track to success!
Create a review
Product Details
- publication date: 08/09/2016
- series: TYW
- book language: en
- publisher: Hodder & Stoughton
- publisher imprint: Teach Yourself
Supported Platforms
- Android Epub DRM Yes
- Ereader Epub DRM Yes
- Desktop Epub DRM Yes
- IOS Epub DRM Yes
- Windows Epub DRM Yes


text:
Born: April 10,1984 Nashua, New Hampshire, United States
Spouse: Ryan Adams
Zodiac: Aries
Height: 5 feet 7 inches
Biography: Mandy Moore is an actress, singer, model and fashion designer. Her debut album Candy was a chartbuster. Her second album So Real so was a success and received a Platinum certification from the RIAA. Her third self-titled album Mandy Moore was a slight deviation from her previous bubblegum pop tracks. Her fourth album was titled Coverage. After taking a break, she released an album called Wild Hope in 2007 and her sixth album Amanda Leigh in 2009. She made her film debut in the 2001 film Dr. Dolittle 2. Some of her other movies include The Princess Diaries, A Walk to Remember, Chasing Liberty, Saved!, How to Deal, Because I Said So and License to Wed. Moore also owns her fashion line called Mblem.


text:
Return to SwingLifeStyle.com The Swingers Home Page
There are a total of 9089 Highland Crest swingers, within 100 miles.
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Create a free swingers account so you can see and write to them all.
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Seeking REAL, fun loving, sexy couples or, of course, single females :-)
Taking Friday....anyone up for some fun??
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Love sucks, but TRUE love swallows
Active Swingers as of 27-Feb-17.
This site does not contain sexually explicit images as defined in 18 U.S.C. 2256.
Accordingly, neither this site nor the contents contained herein are covered by the record-keeping provisions of 18 USC 2257(a)-(c).
Disclaimer: This website contains adult material. You must be over 18 to enter or 21 were applicable by law.
All Members are over 18 years of age.
Terms of Use Privacy Policy


text:
Hydro Flask Wide Mouth Hydro Flip Lid, Perfect Purple
Availability: Only 1 Left In-stock.
Add to Compare
Like all Hydro Flask caps, the Hydro Flip is made out of PP#5 and is BPA-free. The lid features a flip-top opening with rubber stopper to plug the opening and help prevent spills when not in use.
The Hydro Flip lid fits our 12 oz, 16oz, 18 oz, 32 oz, 40 oz and 64 oz Wide Mouth flasks. Please note that the Hydro Flip lid does not fit on the older style Wide Mouth flasks. To find out which style flask you have and whether the Hydro Flip will fit yours, check out the Hydro Flip Fit Guide.
Please note that the Hydro Flip Lid is not leak proof.
Features : The Wide Mouth Flat Caps are insulated to aide in keeping your Hydro Flask contents cold or hot *Fits the 12 oz, 16 oz, 18 oz, 32 oz, 40 oz and 64 oz Wide Mouth Hydro Flasks *Please note that the Insulated Flat Cap does not fit on the older style Wide Mouth flasks *Convert your wide mouth bottle into the perfect thermos for coffe and hot beverages *It never hurts to have extra lids!
Color : Perfect Purple
Size : Wide Mouth
Product dimensions : 0.7x2.3x2.3 inches
Product weight : 0.1 pounds
Write a reviewYour Name:
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text:
Phired Up Is Always Seeking Top Talent
Phired Up is a team of high performers who are deeply dedicated to our mission and to our colleagues. We live what we teach. We have outrageously high expectations. We want people who have a passion (not people that just need a job).
If you're that person, please let us know. We receive a lot of inquiries about employment and/or internships, and can only follow up with those people who show the most promise. We recommend you send the following in a single E-mail to firstname.lastname@example.com
Phired Up Productions is an Equal Opportunity Employer (EOE). Qualified applicants are considered for employment without regard to age, race, color, religion, sex, national origin, sexual orientation, disability, or veteran status. If you need assistance or an accommodation during the application process because of a disability, it is available upon request. The company is pleased to provide such assistance, and no applicant will be penalized as a result of such a request.
All interested intern candidates should complete the application found here.
We currently have no full time positions available. Please check back at a later date.
Site design by Groopt, copyright 2013. All rights reserved


text:
I just finished reading The Girl Who Played With Fire. Why was mathematics so important to Salander?
– Irene Saunders 21 February 2010, 21 February 2010
I am not an expert ,but, some people with Asperger Syndrome have a enhanced understanding of maths an other analytical problems .In girl with the Dragon Tattoo it is mentioned on several occasions that Salander is thought to have Aspergers
– Fiona Scott Scotland, 6 Mars 2010
The Perfect….
– Arif YÜKSEL, 20 February 2010
I just finished reading The Girl Who Played With Fire. I was fully indulged into this master piece of writing and I am fully excited to read his other books with full anticipation. A real shame he passed away.
– Phil, London, England, 20 February 2010
I am so sad to find that this author died at an early age. I have been transported by his first 2 books, and am anticipating "The Girl Who Kicked the Hornet's Nest". His characters are full of life.
– , 19 February 2010
I finished Lisbeth Salander's book 3 and then, because it was the last in the trilogy, promptly immediately read it again. FANTASTIC BOOKS! These are the very best books I have read in a long long time. Stieg Larsson is/was just a stunning writer. Thank you! Are yoiu sure there isn't another (volume 4) secreted away somewhere?
– Steve Roberts, Runcorn, Cheshire. UK., 18 February 2010
I was hooked from the outset and loved every twist and turn….the best I have read in a long time.
– WK, 15 February 2010
Having just finished "The Girl With The Dragon Tattoo" I have to say I was impressed. Clearly it is a fine book – sadly it it at least 200 pages too long. Here's a writer with real talent desperately in need of an editor.
Dan Fante
– , 15 February 2010
It took awhile to get into the story, as there's quite a lot of unneccesary discription and so many characters, but once I did , I couldn't put it down. Can wait to read the next two. How ad that there won't be anymore. 🙁
– TLR, 17 February 2010
I just finished "The Girl With The Dragon Tattoo".. Thumbs Up !!
– , 17 February 2010
Just finished the trilogy and all i can say is wow.
– Sam, 15 February 2010
Curoious how you finished the trilogy when the third book is not out yet.
– paul, 19 February 2010
Ok I see it's out in Europe sorry really looking forward to reading it.
– paul, 19 February 2010
Just Finished The Girl Who Kicked The Hornet's Nest. And I have to say that I'm quite sad, due to the fact that, there aren't any more books and nor will there be. Thoutgh I've heard rumours that there is a 4th book. One could only hope.
– Ernie P. (South-Africa), 15 February 2010
First I only watched the movie "the girl with the dragon-tattoo" I liked but I didn't think it to be that great… Besides I don't really like the writing-style of most of the nordish authors… But then I read "the girl with the dragon-tattoo" and I was absolutly thrilled… Though I knew the story and the solution of the book it captivated me from the first to the last page… Read all the nearly 700 pages in one day…
Absolutly genius..
– Sarah S. (Germany), 14 February 2010
Sarah, may I ask? When did you see the movie? Here in the US it's not out at all…..
– D.C. (USA), 20 February 2010
Not every film is released in the US first. Believe it or not there is a thriving film business outside L.A.
– SY (USA), 9 Mars 2010


text:
Emiratis can be sacked only if they violate law
Dubai: Private sector companies will face legal action if they sack Emiratis who have not violated the labour law, according to a new decision by the Ministry of Labour.
The decision comes after Al Futtaim Group sacked a number of Emiratis. Al Futtaim Group had said they were terminated because the company was "restructured in light of the current global financial crisis."
The new ministerial decision, regulating the termination of Emiratis in the private sector, issued on Tuesday, stipulates that companies can only sack Emiratis if they have violated the labour law, such as non-performance of basic duties, committing mistakes, which result in substantial material loss for the employer.
In other cases, companies must go back to the ministry before sacking Emiratis. Companies that do not comply will face legal action and the ministry will enforce a ban on issuing them new work permits until a court verdict is passed, according to the new decision.
Humaid Bin Deemas, acting director-general at the ministry, said the new decision is aimed at outlining the rights and duties of both employers and Emiratis in the private sector.
"The decision is to regulate the termination of Emiratis working in the private sector. It does not deprive the employer of the right to hold Emiratis accountable for their low-performance," said Bin Deemas.
Any termination of Emiratis will be considered unlawful if the same job is given to expatriates in light of restructuring policies of companies.
"The priority for work is for Emiratis and this right is protected in the labour law," said Bin Deemas.
Ahmad Al Naqbi, one of the Emiratis, who was sacked by Al Futtaim Group, said the decision indicated the government's commitment to protect their citizens.
Feddah Lootah, acting director-general at the National Human Resource Development and Employment Authority (Tanmia), said this decision will curb the practice of some companies to exploit the current global financial situation to escape from their Emiratisation responsibilities.
The rule will cover 14,861 Emiratis who work in the private sector and are currently registered at the Ministry of Labour. It does not cover Emiratis working in semi-government companies.


text:
The Foundation is proud to present a full day of presentations and discussions on osteopathic medicine and why it might be the best choice for students looking for a career in medicine. The content of this workshop is developed for pre-med students at the university / college level and pre-med advisors at the university / college and high school level.
This workshop is part of our Northwest Wellness Conference being held on March 5, 2016 on the campus of Western University / College of Osteopathic Medicine Pacific-Northwest in Lebanon, OR. The seminar fee is $15 for those that register on line and $25 at the door. The fee covers breakfast, the opening presentation, "What Makes Medicine Osteopathic?" and lunch. Registration, breakfast, and exhibits begin at 8:00 am and concludes at 5:00 pm. Registration is now open for this seminar.
This workshop is being coordinated by John T. Pham, DO, Vice Chair and Assistant Professor of Family Medicine at Western University / College of Osteopathic Medicine of the Pacific-Northwest.
Work Outline
8:00 – Registration
9:00 – Breakfast and Keynote Address "What Makes Medicine Osteopathic"
10:00 – Introductions / Ladder to Success as a Physician; John Pham, DO
10:20 – Introduction to Osteopathic Medicine; Jay Anderson, OMS II, COMP – Northwest
11:00 – AACOM Nuts and Bolts of the Application Process, Stephanie Wurth, Director of Application Services, Recruitment & Student Affairs
11:30 – Effective Personal Statements, Jeannie Davis, Director of Admissions, COMP-NW
12:00 – Lunch and Networking
1:00 – Mock Medical School Interviews
2:00 – Medical Schools Curriculum and Panel on Student Life
3:00 – Clinical Skills Demonstrations
Tours of the COMP-NW campus will be available for participants in this workshop.
Representatives from the American Association of Colleges of Osteopathic Medicine (AACOM) and several osteopathic medical schools will be on hand to answer questions and give students and advisors information on their programs.
The Northwest Wellness Conference is a one-day opportunity for physicians, hospitals, medical schools, and the general public to come to and explore how we Advance Wellness through the Osteopathic Approach. During the day there will be seven concurrent workshops on a wide variety of topics.
The Northwest Wellness Conference is not only educational, but the proceeds from the event supports our scholarship program.You can get information on all aspects of the conference here.
Please contact Foundation Executive Director David Tate @ 503-222-7161 or email@example.com for additional information.
Hotel reservations can be made by contacting the Best Western Boulder Falls Inn in Lebanon, OR at 541-451-1000 // 1-844-434-3400
Use the "Join Our Email List" link on the right side of this page to get updated information on this seminar, then select "Founders and Wellness Conference."


text:
Targeted molecular agents are a landmark achievement in cancer treatment. In particular, the tyrosine kinase inhibitor imatinib mesylate targets mutant KIT protein in gastrointestinal stromal tumor (GIST), an intestinal sarcoma. While imatinib is remarkably effective, it almost never induces a complete response and tumor progression occurs at a median of approximately 20 months. During our 5 years of funding, we defined the relationship of conventional pathologic variables and the type of KIT mutation to outcome following the resection of primary GIST in humans and identified the mechanism of acquired resistance to imatinib. Our focus has evolved and now our goal is to combine immunotherapy with imatinib to improve outcomes in GIST. We hypothesize that tumor antigen release resulting from the rapid tumor destruction induced by imatinib can be exploited by using concomitant immunotherapy. In a transgenic mouse that develops GIST spontaneously, we have found that the anti-tumor effects of imatinib are partially immune-mediated. We have discovered that imatinib decreases tumor production of indoleamine 2,3-dioxygenase (IDO), a key immunosuppressive protein. We have also found that imatinib has enhanced anti-tumor efficacy when combined with antibody-mediated blockade of CTLA-4, an immunomodulatory protein expressed by activated T cells and constitutively by regulatory T cells.
In Aim 1, we will demonstrate that the anti-tumor effects of imatinib in GIST depend on inhibition of IDO.
In Aim 2, we will determine how glucocorticoid-induced tumor necrosis factor receptor ligand modulates the anti-tumor effects of imatinib.
In Aim 3, we will define how CTLA-4 blockade enhances the anti-tumor effects of imatinib in GIST. Our findings will advance our understanding of GIST and may lead to a novel clinical trial using combined molecular and immune therapy.
In this proposal, we will investigate the role of the immune response in the effects of targeted molecular therapy against cancer. We will combine molecular therapy with immunotherapy in a mouse model of gastrointestinal cancer. Our investigations may identify a more effective approach to treating patients with cancer.
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