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We have a select number of 2017 Spring and Summer dates available at special pricing!
With 93 well-appointed guest rooms, two award-winning restaurants and private banquet space, we can accommodate your welcome receptions, brunches and more. Offer your guests the convenience of staying at the Hawthorne and eliminate the need to drive, so that everyone can enjoy the wedding in a relaxing atmosphere.
From contemporary chic to classic sophistication, let our wedding team turn your dream into reality. Our experienced wedding professionals are here to advise you on everything from entertainment and florists to photographers and menu selections, and will take your worries away from the moment you start planning.
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We could not be happier with the Hawthorne and everything they did to make our wedding day perfect. They set up everything exactly as requested and it was so lovely. Our coordinator was very responsive and on top of every detail and the food was excellent. We are so grateful for all the effort that went into making our day so special and will always remember the Hawthorne as the place where our married life began.
With a history dating back to 1925, our passion for weddings remains as vivid today as it was then. Filled with historic details, yet stylish and modern in approach, our 19-foot tall Grand Ballroom offers an unforgettable venue with an expansive interior and magnificent Palladian windows to bring a spacious elegance to your wedding.
Located in the heart of historic Salem, the Hawthorne is an ideal setting for family and friends. From the adjacent 76-acre Salem Common to the nearby Maritime and Salem Harbor backdrops to the quaint nooks and crannies of the downtown area with its bustling restaurants, bars and attractions. Turn your wedding into a festive weekend journey.
Christine Madigan, Catering Sales Office Manager – 978-825-4358


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This review is from: AMD FX-4170 Zambezi Quad-Core 4.2GHz (4.3GHz Turbo) Socket AM3+ 125W FD4170FRGUBOX Desktop Processor
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- Forum: Classic Menswear
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Has anyone gathered more info on the Design Your Own Suit option? I'm looking for a three piece suit, and the RTW offerings don't have what I'm looking for. The Design Your Own works great, just seems a bit on the pricey side. Especially considering the Lazio fits me pretty well off the rack. I'd just buy OTR if they offered a matching waistcoat. MTM is not an option as I am in LA, and the store here does not offer that service. Thanks for the info.


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Dont risk your battery with old school jumper cables! Automotive batteries don't last for ever. There are a variety of car problems that can drain a battery. The battery can be drained to levels where it will not have enough energy to crank your car. Even new batteries can be drained to failure levels. This has happened to most of us at some point of our lives and we all know it would be useful to know someone local and personable to come out in this time of need. Give us a call if your in the Broward, Dade or Palm beach counties.
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Did you run out of gas in the Broward County area? Give us a call, and we will to come out and deliver enough fuel to get you to the nearest gas station. If your stranded on the side of the road and you need regular gas or diesel, we are the ones to call. We can be out in a timely manner and get you off the side of the road and on the way to your local fuel station.
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TRICARE's over-the-counter (OTC) drug coverage is here to stay. Formerly a demonstration program, the OTC benefit becomes a permanent part of the TRICARE pharmacy benefit on Feb. 1, 2016. Effective that date, TRICARE is making some changes to OTC coverage to bring it in line with other TRICARE pharmacy coverage.
Starting Feb. 1, beneficiaries must pay the usual generic copays for covered OTC drugs. OTC drug coverage will still require a prescription from their doctor. Female beneficiaries can still get LevonorgestrelEmergency contraceptive used to prevent pregnancy. It's also known as Plan B. It's available to all beneficiaries for free without a prescription. (the Plan B one-step emergency contraceptive), without a copay or prescription at a network or military pharmacy.
Feb. 1 also brings a change to which drugs are available under the OTC benefit. The allergy medications Cetirizine and Loratadine were previously covered, but now the versions that contain pseudoephedrine are also covered. However, brand name Prilosec OTC is no longer covered. The generic version, Omeprazole, is still covered, as is the prescription version of Prilosec.
Visit the TRICARE Pharmacy page for more information on the TRICARE pharmacy benefit. If you have questions about whether or not one of your drugs is covered, you can always call the TRICARE pharmacy contractor, Express Scripts, at 1-877-363-1303.
Last Updated 1/17/2017
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Recent Meetups
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Questions and such
1. It starts at 10pm, so we drive through the night?
Careen. You careen through the night. There is also occasional swerving.
2. Where do we sleep?
We reserve a block of rooms at a hotel. It's a pretty swell place. Has beds and everything.
3. Is the hotel included in the ticket price?
Not in the basic ticket, no. But the hotel, by virtue of being located in someplace you'd never willingly stop on your lonesome, is mighty inexpensive. Alternatively, If you're rich and/or lazy, you may purchase the Viterbo ticket, which includes a hotel room in the price (not to mention we bring you a cooked state on a silver platter at the starting line).
4. So what is included in the ticket price?
We choose the checkpoints, create the itinerary, and give you briefcases filled with mischief-making tools. And then we loose you upon the world to have a madcap, roving party that's one-half Cannonball Run, one part Wacky Races, and all parts titillating. It's great fun. Do join us sometime.
5. How far from the starting line are we going?
We could tell you, but where's the fun in that.
6. Must I rent a car? Can I use my own?
No, you mustn't. Yes, you can. But please read the Rally Vehicles section that we so laboriously constructed for your edification. Spanks.


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Summary | Excerpt | Reviews | Beyond the book | Readalikes | Genres & Themes | Author Bio
The Mission to End Genocide in Darfur and Beyond
From the book jacket: While Don Cheadle was filming Hotel Rwanda,
a new crisis had already erupted in Darfur, in nearby Sudan. In September 2004,
then-Secretary of State Colin Powell termed the atrocities being committed there
"genocide" -- and yet two years later things have only gotten worse. 3.5 million
Sudanese are going hungry, 2.5 million have been displaced by violence, and
400,000 have died in Darfur to date.
Both shocked and energized by this ongoing tragedy, Cheadle teamed up with leading activist John Prendergast to focus the world's attention. Not on Our Watch, their empowering book, offers six strategies readers themselves can implement: Raise Awareness, Raise Funds, Write a Letter, Call for Divestment, Start an Organization, and Lobby the Government. Each of these small actions can make a huge difference in the fate of a nation, and a people -- not ...
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Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells
© Goncharova et al.; licensee BioMed Central Ltd. 2012
Received: 14 February 2012
Accepted: 3 September 2012
Published: 27 November 2012
Increased pulmonary arterial vascular smooth muscle (PAVSM) cell proliferation is a key pathophysiological component of pulmonary vascular remodeling in pulmonary arterial hypertension (PH). The long-acting β2-adrenergic receptor (β2AR) agonist formoterol, a racemate comprised of (R,R)- and (S,S)-enantiomers, is commonly used as a vasodilator in chronic obstructive pulmonary disease (COPD). PH, a common complication of COPD, increases patients' morbidity and reduces survival. Recent studies demonstrate that formoterol has anti-proliferative effects on airway smooth muscle cells and bronchial fibroblasts. The effects of formoterol and its enantiomers on PAVSM cell proliferation are not determined. The goals of this study were to examine effects of racemic formoterol and its enantiomers on PAVSM cell proliferation as it relates to COPD-associated PH.
Basal, thrombin-, PDGF- and chronic hypoxia-induced proliferation of primary human PAVSM cells was examined by DNA synthesis analysis using BrdU incorporation assay. ERK1/2, mTORC1 and mTORC2 activation were determined by phosphorylation levels of ERK1/2, ribosomal protein S6 and S473-Akt using immunoblot analysis.
We found that (R,R) and racemic formoterol inhibited basal, thrombin- and chronic hypoxia-induced proliferation of human PAVSM cells while (S,S) formoterol had lesser inhibitory effect. The β2AR blocker propranolol abrogated the growth inhibitory effect of formoterol. (R,R), but not (S,S) formoterol attenuated basal, thrombin- and chronic hypoxia-induced ERK1/2 phosphorylation, but had little effect on Akt and S6 phosphorylation levels. Formoterol and its enantiomers did not significantly affect PDGF-induced DNA synthesis and PDGF-dependent ERK1/2, S473-Akt and S6 phosphorylation in human PAVSM cells.
Formoterol inhibits basal, thrombin-, and chronic hypoxia-, but not PDGF-induced human PAVSM cell proliferation and ERK1/2, but has little effect on mTORC1 and mTORC2 signaling. Anti-proliferative effects of formoterol depend predominantly on its (R,R) enantiomer and require the binding with β2AR. These data suggest that (R,R) formoterol may be considered as potential adjuvant therapy to inhibit PAVSM cell proliferation in COPD-associated PH.
Keywords(R R) formoterol ERK1/2 Pulmonary hypertension
Pulmonary arterial vascular smooth muscle (PAVSM) cell proliferation is one of the key pathophysiological components of vascular remodeling in pulmonary hypertension (PH) [1, 2]. PH is a common complication of chronic obstructive pulmonary disease (COPD), which is strongly associated with decreased quality of life, increased morbidity and reduced survival of COPD patients [3, 4]. The major pathological manifestations of PH are vasoconstriction and remodeling of small muscular pulmonary arteries (PA). Prolonged exposure to hypoxia, growth factors and pro-inflammatory cytokines induces PAVSM proliferation and pulmonary vascular remodeling leading to persistent elevation of pulmonary vascular resistance, right ventricular failure and death [2, 5, 6]. Systemic vasodilators, however, have not been found to be effective therapy for COPD-associated PH [6] and therapeutic options to target pulmonary vascular remodeling are needed.
β2 adrenoreceptor (AR), a member of the G-protein coupled receptor family, is the major subtype of βAR in SM cells. Binding with β2AR agonists induces β2AR coupling with Gs proteins, activation of adenylate cyclase and increase of cellular cAMP levels leading to parallel activation of protein kinase A (PKA) and Epac1 that synergize in mediating cAMP-dependent growth inhibition of VSM cells [7–11] suggesting that β2AR agonists may be considered as an attractive therapeutic approach to inhibit PAVSM cell proliferation in PH.
Formoterol is a long-acting β2AR agonist that is commonly used as a bronchodilator to treat patients with COPD [12, 13]. Formoterol is available in two formulations: racemic formoterol that consists of equal amounts of (R,R) and (S,S) enantiomers, and purified (R,R) formoterol. (R,R) formoterol has 1000-times greater affinity to β2AR than (S,S) enantiomer and shows improved bronchodilator effects compared to formoterol racemate [8]. Recent data demonstrate that, in addition to its function as a bronchodilator, racemic formoterol also acts as an anti-proliferative agent for airway smooth muscle cells [9] and human bronchial fibroblasts [14]. Currently, no information is available about the effects of formoterol in PAVSM cell proliferation as it relates to COPD-associated PH, and comparative effects of racemic formoterol vs. its (R,R) and (S,S) enantiomers on PAVSM cell proliferation are also not examined.
The mechanisms by which formoterol regulates cell proliferation are not well understood. cAMP uptake regulates Raf1-extracellular signal-regulated kinases 1/2 (ERK1/2) cascade via PKA-specific direct phosphorylation of Raf1 or PKA- and Epac1-dependent Rap1 regulation [7, 15–18]. cAMP is also shown to down-regulate protein tyrosine phosphorylation in VSM cells [19]. Studies from our laboratory and others demonstrate that ERK1/2 and mammalian target of rapamycin (mTOR), downstream effectors of receptor tyrosine kinases (RTK), are two major positive regulators of PAVSM cell proliferation induced by mitogens and chronic hypoxia [20–25]. ERK1/2 is required for PDGF-, insulin- and thrombin-induced proliferation of aortic and pulmonary arterial VSM cells [22, 23]; and pharmacological inhibition of MEK-ERK1/2 signaling abolishes chronic hypoxia-induced rat PAVSM cell proliferation [24]. mTOR forms two functionally distinct complexes, mTORC1 and mTORC2 [25, 26]. Chronic hypoxia, PDGF, and thrombin activate mTORC1 in PAVSM and endothelial cells that, in turn, stimulates cell growth via regulation of S6 kinase 1 (S6K1) and 4 EB-P1 [20–25]. The mTORC1 inhibitor rapamycin attenuates pulmonary vascular remodeling in experimental PH [27, 28] and demonstrated benefits in treatment of patients with PH [29]. mTORC2 activates serine-threonine kinase Akt via specific phosphorylation at S-473 [30]. We recently reported that chronic hypoxia and PDGF activate mTORC2 signaling that is required for proliferation of human and rat PAVSM cells [25]. The effects of formoterol and its enantiomers on ERK1/2 and mTOR signaling pathways in PAVSM cells, however, remain to be elucidated.
The goal of this study was to evaluate the effects of racemic formoterol and its (R,R) and (S,S) enantiomers on proliferation of human PAVSM cells induced by PDGF, thrombin, and chronic hypoxia, recognized triggers of PAVSM cell proliferation and vascular remodeling in COPD-associated PH [31]. We found that formoterol inhibits basal, thrombin-, and chronic hypoxia-, but not PDGF-induced proliferation of human PAVSM cells and ERK1/2 phosphorylation while having little effect on mTOR signaling. We also show that the anti-proliferative effects of formoterol require its binding with β2AR and that (R,R) formoterol shows improved anti-proliferative effects compared to racemic formoterol. Taken together, our data demonstrate that formoterol inhibits human PAVSM cell proliferation caused by certain PH-related stimuli and suggest that (R,R) formoterol may be considered as a potential adjuvant therapy to attenuate PAVSM cell proliferation in COPD-associated PH.
Cell culture
Human PAVSM cells were dissociated from pulmonary arteries from failed donor lungs that were obtained from the National Disease Research Interchange (NDRI) (Philadelphia, PA), in accordance with procedures approved by the University of Pennsylvania Committee on Studies Involving Human Beings as previously described [20, 25]. Briefly, a segment of human pulmonary artery just proximal to the lung entry was removed under aseptic conditions, cleaned from connective and fat tissues and dissected as follows: the media of pulmonary artery was dissected from the adventitia and intima and subjected to an enzymatic digestion in 10 ml of buffer containing 0.2 mM CaCl2, 640 U/ml collagenase, 1 mg/ml soybean trypsin inhibitor and 10 U/ml elastase for approximately 60 min in a shaking water bath at 37°C. The cell suspension was filtered through 105 μm Nytex mesh, and the filtrate was washed with equal volumes of cold Ham's F-12 medium (Life Technologies, Grand Island, NY) supplemented with 10% FBS (HyClone, Logan, UT). Cells were plated on tissue culture plates covered with Vitrogen (Cohesion Technologies Inc., Palo Alto, CA). Cells were cultured in Ham's F-12 media supplemented with 10% FBS (Becton Dickinson, Bedford, MA), 100 U/ml penicillin, and 0.1 mg/ml streptomycin.
For chronic hypoxia experiments, cells were maintained either in normoxic (21% O2, 5% CO2) or in hypoxic (1% O2, 5% CO2) conditions for 7 days in complete media and then for 48 h in serum-free media supplemented with 0.1% BSA. 1% O2 was used as we described [25] to reproduce the tissue oxygen levels of moderate chronic hypoxia [32, 33] based on data obtained from the rat chronic hypoxia model of PH [34, 35]. To avoid re-oxygenation, fresh complete or serum-free media was pre-equilibrated at 1% O2, before adding to PAVSM cells grown under hypoxia. Primary human PAVSM cells in subculture during the second through tenth cell passages were used. All experiments were performed using a minimum of three different cell cultures. Each human PAVSM cell culture was established using pulmonary arterial tissue from a single human donor.
DNA synthesis analysis
Cells grown under normoxia or chronic hypoxia were serum deprived for 48 h, treated with 0.1, 1, or 10 ng/ml PDGF-BB, 1 U/ml thrombin, 0.2, 2, or 20 μM racemic, (R,R), or (S,S) formoterol, or diluent for 18 h followed by DNA synthesis analysis using the BrdU incorporation assays as we described [25, 36–38]. Briefly, cells were incubated with 10 μM BrdU for 24 h, fixed with 3.7% paraformaldehyde (Polysciences, Inc., Warrington, PA) for 15 min and permeabilized with 0.1% Triton X-100 for 30 min at room temperature. Following denaturation of DNA with 4 N HCl (3 min at room temperature), incubated for 1 h at 37oC with 2 μg/ml murine anti-BrdU primary (Becton Dickinson, San Jose, CA) and 10 μg/ml Texas Red-conjugated anti-mouse secondary (Jackson ImmunoResearch Laboratories, West Grove, PA) antibodies for 1 h at 37°C to detect BrdU-positive cells. To detect the total number of nuclei, cells were incubated with 1 μg/ml DAPI. Then, cells were visualized using Eclipse Nikon TE2000E fluorescent microscope (200x magnification), and automatic counts of BrdU-positive and total number of cells were performed using Image-Pro Plus 5.1 software.
Immunoblot analysis
Whole cell lysates were prepared using a buffer comprised of 40 mM HEPES (pH 7.5), 120 mM NaCl, 1 mM EDTA, 10 mM sodium pyrophosphate (Na4P2O7 x 10H2O), 10 mM β-glycerophosphate, 50 mM NaF, 1.5 mM Na3VO4, 1% Triton X-100, EDTA-free inhibitor cocktail. Protein contents were measured using a Bio-Rad protein assay reagent kit. Equal amounts of lysate, adjusted for protein content, were subjected to SDS-PAGE and then immunoblot analysis. The blots were exposed to anti-phospho-S6 ribosomal protein, anti-total S6, anti-phospho Akt Ser-473, anti-total Akt, anti-phospho ERK, anti-total ERK, anti-phospho S6K1 T-389, and anti-total S6K1 antibodies (Cell Signaling Technology, Inc., Beverly, MA). All antibodies were in 20 mM Tris (pH 7.5), 150 mM NaCl (TBS) plus 0.5% Tween 20 (TBST), and all incubations were for overnight at 4°C. After 3 washes in TBST, the nitrocellulose membranes were exposed to horseradish peroxidase-conjugated secondary antibody (Boehringer-Mannheim, Indianapolis, IN), washed five times in TBST and visualized using enhanced chemiluminescence (ECL) (Amersham, Arlington Heights, IL).
Data analysis
Data points from each condition are represented as the mean values ± SE. Three independent repetitions were performed for each experimental condition. Statistical analysis was performed using StatView software. Statistically significant differences among groups were assessed with the analysis of variance (ANOVA) (Bonferroni-Dunn) with values of p < 0.05 sufficient to reject the null hypothesis for all analyses. All experiments were designed with matched control conditions within each experiment to enable statistical comparison as paired samples.
Formoterol inhibits basal and thrombin-, but not PDGF-induced human PAVSM cell proliferation
Formoterol inhibits PAVSM cell proliferation caused by chronic hypoxia exposure
Binding with β2AR is required for formoterol-induced inhibition of human PAVSM cell proliferation
(R,R) formoterol inhibits basal and thrombin-, but not PDGF-induced ERK1/2 phosphorylation in human PAVSM cells
Formoterol has no effect on mTOR signaling in human PAVSM cells
PH is a progressive disease with poor prognosis, the pathological manifestations of which include vasoconstriction and pulmonary vascular remodeling [5, 45]. PH may be familial, idiopathic, or associated with other diseases. Notably, patients with COPD-associated PH have higher morbidity and reduced survival compared to other COPD patients [3, 4]. Pulmonary vascular remodeling in PH is associated with marked medial thickening of small muscular PAs due, at least in part, to increased proliferation of PAVSM cells. PAVSM cell proliferation in COPD-associated PH is caused by multiple factors including persistent hypoxia and increased production of growth factors and pro-inflammatory cytokines [2, 31, 46]. Our study demonstrates that β2AR agonist formoterol inhibits proliferation of PAVSM cells induced by thrombin and chronic hypoxia, but not PDGF. Anti-proliferative activity of formoterol requires binding with β2AR, and (R,R) enantiomer of formoterol shows improved anti-growth effects compared to racemic and (S,S) formoterol. We also report that formoterol inhibits basal and thrombin-induced activation of ERK1/2, but has no effect on mTOR signaling in human PAVSM cells.
Deregulated PAVSM cell proliferation is one of the major pathological components of pulmonary vascular remodeling in PH. The long-term β2AR agonist formoterol, which is currently in use as bronchodilator in COPD, shows anti-proliferative activities in human airway smooth muscle cells and bronchus fibroblasts [9, 14]. In the present study, we explored effects of formoterol on human PAVSM cell proliferation caused by different stimuli involved in PH pathogenesis [2, 31, 47] and found that the growth-inhibitory potency of formoterol highly depends on extracellular stimuli. Thus, formoterol and, especially, its (R,R) enantiomer, inhibited proliferation of non-stimulated PAVSM cells under chronic hypoxia, decreased thrombin-induced proliferation, but had no significant effect on PDGF-dependent PAVSM cell growth.
The mechanisms of β2AR-dependent regulation of cell proliferation are relatively unexplored and appear to be highly cell type-specific. β2AR-induced PKA activation, while inhibiting proliferation in the majority of cell types including vascular smooth muscle cells [8–11, 48, 49] stimulates proliferation of human uveal melanoma cells [50] and cardiomyocyte hypertrophy [51]. Activation of β2AR-cAMP signaling also up-regulates Epac1, the predominant Epac isoform in VSM cells [7]. Epac1 synergizes with PKA in inhibiting VSM cell proliferation [7], but increases DNA synthesis in macrophages and prostate cancer cells [52, 53]. Our data show that formoterol-dependent inhibition of human PAVSM cells requires its binding with β2AR. Accordingly, (R,R) formoterol, which has much higher receptor affinity and greater potency to induce β2AR-Gs-dependent cAMP production and PKA activation compared to (S,S) formoterol [8, 54], demonstrates greater anti-proliferative effects than formoterol racemate while (S,S) formoterol has modest effects on PAVSM cell proliferation.
Emerging evidence shows that, in addition to classical Gs-cAMP pathway, β2AR may interact with Gi proteins that, in contrast to Gs, leads to reduction of cAMP levels and inhibition of PKA-dependent signaling [55]. Currently, no evidence exists about involvement of Gi in PAVSM cell proliferation and pulmonary vascular remodeling in PH. In contrast, Gs-dependent activation of cAMP-PKA signaling is well documented in human ASM and PAVSM cells upon formoterol treatment and is required for bronchodilatory and vasodilatory effects of formoterol on COPD patients and for inhibition of SM cell proliferation [7–11, 56]. Gi overexpression, however, has been reported in heart and aorta of spontaneously hypertensive rats; and Gi suppression with pertussis toxin attenuated development of high blood pressure in this model [55, 57–59] suggesting differential mechanisms of β2AR signaling in heart vs. pulmonary vasculature.
The signaling pathways underlying formoterol-dependent inhibition of cell proliferation are not well evaluated. We and others previously demonstrated that thrombin promotes human PAVSM cell proliferation via ERK1/2 signaling while PDGF acts via activation of two major pro-proliferative pathways, PI3K-mTOR and MEK-ERK1/2 [60]. In the majority of cells, including VSM, cAMP-dependent activation of PKA and Epac inhibits ERK1/2 signaling via modulating activities of small GTPases Raf-1 and Rap-1 downstream of Ras [15, 61, 62] clearly demonstrating functional cross-talk between ERK1/2 and β2AR-cAMP cascades.
Interestingly, we found that formoterol markedly inhibits thrombin-, but not PDGF-induced ERK1/2 phosphorylation. A possible explanation is that PDGF, in addition to ERK1/2, also promotes strong up-regulation of PI3K signaling [20, 25], and we found that PI3K is insensitive to formoterol. PI3K stimulates ERK1/2 activation via Raf-1 and Rap-1 in a Ras-independent manner [63, 64] and can counter-balance formoterol-β2AR-cAMP-dependent ERK1/2 inhibition. Indeed, our data show that formoterol markedly inhibits ERK1/2 phosphorylation in chronic hypoxia-exposed PAVSM cells, in which mTOR activation and proliferation occur in a PI3K-independent manner [25].
Chronic hypoxia-induced proliferation of PAVSM cells requires expression of hypoxia-inducible factor 1 α (HIF1α), which plays a critical role in PAVSM remodeling in human and experimental PH [31, 65]. Notably, ERK1/2 up-regulates HIF1α transcriptional activity via direct phosphorylation that promotes HIF1α nuclear translocation or via regulating binding of HIF1α with its major co-activator p300/cAMP response element-binding protein (CBP) [66–69]. Thus, formoterol may inhibit chronic hypoxia-induced PAVSM cell proliferation via down-regulation of ERK1/2-dependent HIF1α transcriptional activity.
Although much less is known about the regulation of the mTOR signaling pathway by cAMP/PKA, it is shown that cAMP elevation inhibits mTORC1/S6K1 in T lymphocytes [70], but not in CCL39 fibroblasts [71] suggesting that effects of cAMP/PKA on mTOR activation are cell type-specific. Our data show that formoterol has no effect on activation of mTORC1 and mTORC2 signaling pathways caused by either PDGF or chronic hypoxia. These data indicate that mitogen- and chronic hypoxia-induced mTOR activation in human PAVSM cells is β2AR-independent.
Taken together, our study demonstrates that formoterol inhibits basal, chronic hypoxia- and thrombin-, but not PDGF-induced human PAVSM cell proliferation potentially via β2AR-dependent inhibition of ERK1/2 signaling pathway; and that anti-proliferative activity of formoterol is provided predominantly by its (R,R) enantiomer. This data suggests that (R,R) formoterol, while having a limited effect as a single agent, may be considered as a potential adjuvant therapy for COPD-associated PH.
Collectively, our data demonstrate that the β2AR agonist formoterol inhibits basal, thrombin-, and chronic hypoxia-induced ERK1/2 activation and proliferation of human PAVSM cells, but has little effect on PDGF-induced ERK1/2 activation, proliferation and mTOR signaling. We also show that formoterol acts predominantly through its (R,R) enantiomer and that anti-proliferative effects of formoterol require β2AR binding. These data suggest that (R,R) formoterol inhibits human PAVSM cell proliferation in certain conditions and may be considered as a potential adjuvant therapy for COPD-associated PH.
Analysis of variance
- β2AR:
β2-adrenergic receptor
- BrdU:
Chronic obstructive pulmonary disease
Extracellular signal-regulated kinases ½
- HIF1α:
hypoxia-inducible factor 1 α
- mTOR:
Mammalian target of rapamycin
Mitogen-activated protein kinase
MAP kinase kinase
National Disease Research Interchange
- PAs:
pulmonary arteries
Pulmonary arterial vascular smooth muscle
platelet-derived growth factor
Pulmonary hypertension
Protein kinase A
Receptor tyrosine kinase
p70 S6 kinase 1.
We thank the National Disease Research Interchange (NDRI) for providing us with human lung tissue and Ms. Mary McNichol for critical reading of the manuscript. This work is supported by Sepracor (V.P.K.) and, in part, by a Gilead Science Research Award (E.A.G.), an American Lung Association Research Award (E.A.G.), the University of Pennsylvania Research Foundation (E.A.G.), and NIH/NHLBI 1R01HL113178 (E.A.G).
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There are not so many hotel rooms in Skulli, just 2, still everyone can find an offer to suit his choice. The most common offers in this city are guest houses, they count 2 out of 2, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the west of Skulli, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Skulli. The most populated with hotels district of Skulli is the south, 50% of cheap hotel rooms are concentrated here. Skulli is a truly multifaceted city, here everyone can find a hotel of his choice: a business person, a young couple or a family with little children. Apart from all these, hotels in Skulli offer their customers swimming pool. Take a look at our selection of the cheap hotel rooms in Skulli to make a well-informed choice for your reservation!
Skulli cheap hotels
Guest Houses
All cheap hotels in Skulli
Best hotels in Skulli
Hotels in Skulli are spread around the city within the distance of 1.6 kilometers. The most popular accommodations in Skulli is
Aphrodite Villa
located in a 1.4 kilometers from the city center.
The best hotels are here and now. Try them!
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Play Ball
Spring 2016 Season
Registration online is open through April 1, 2016. Click this link http://app.myezreg.com/Leagues/Login/mlwestmi to register. We will play each Saturday from April 30, 2016 through June 1, 2016. (Except May 28 we will have a special clinic with the West MI Whitecaps instead of games.) Children ages 5-18 are eligible at this time. Information for parents and guardians is available here. Create a family account
- $40 registration fee.
Scholarships are available for children who are unable to pay the registration fee. To request a scholarship, please contact us explaining your request.


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Suthurn Swaggur is a rock band with strong southern and blues roots based out of Nashville, Tennessee. The founding members, Jeff Agia and Joey Dawson, both Florida natives, met in college while pursuing their Bachelors Degrees in Recording Arts. They soon realized they had many things in common which included their eclectic taste in music, goals, interests and influences. They both wanted to write original music so they decided to start writing songs together. This then quickly led to them wanting to perform that original music which eventually led to the start of the band Suthurn Swaggur.
They both had a great affinity for Southern Rock as well as other musical genres. Southern Rock was the foundation for their sound but they wanted to incorporate blues, classic rock, alternative, pop, country and even hip-hop influences. Drawing from their varied backgrounds in music, they began forging their own sound and style and soon had dozens of songs written.
Jeff is an accomplished guitar player and music producer and writes the music and arrangements for their songs. He also has experience in creating hip-hop and even worked at Hans Zimmer's Remote Control Studios, where he learned about film scoring. Joey writes the lyrics and melodies for the songs. He got his start as a DJ and even toured the country with a signed band as their turntablist creating sounds, scratches and phrases from individual pieces of vinyl to create a completely new and unique sound effect. Adding turntablism to their songs created their own sound that has never been done before in this type of music.
Suthurn Swaggur is a band on the rise. They are beginning to attract the attention of record labels and talent agencies for their ability to write catchy songs and putting on rockin' live shows. Their goals are to get signed, tour and share their music with the world.


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Boxed - Small Slider - Formwork Epping
Ignazio Modica Formwork & Carpentry
Ignazio Modica Formwork & Carpentry is Epping based company that services Essendon to Glen Waverly and Craigieburn to Campbellfield. Providing a vast range of commercial and residential services, we cover everything from concrete columns and stairs, to suspended slabs, bricklaying and earthworks.
With over 10 years of experience our team excels in getting the job done fast, whilst still maintaining the highest possible quality.
Get in touch with a member of our team on 0432 396 330 today to find out what we can bring to your premises.Contact Us


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Welcome to the Blackboard e-Education platform—designed to enable educational innovations everywhere by connecting people and technology.
For Blackboard, please use the following browsers:
Google Chrome Click here to access the download page for Chrome
Mozilla Firefox Click here to access the download page for Firefox
Do not use Internet Explorer (the "blue 'e' icon" on your computer) for Blackboard. Download and install Chrome or Firefox.
But remember: All web browsers have their issues, especially when saddled with additional plug-ins and extras such as toolbars. Make sure that all of your software (including Java) is kept current with updates. Machines with software conflicts, malware, or other issues will be problematic regardless of what browser is used.


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I'm snorkelling with mermaids under a sparkling blue sky. Their soft chirruping song washes over me, luring passing boaters into warm waters fringed by swaying palms. It may sound like just another cheesy Disney "experience", but this is Florida's other magical kingdom – a wonderland of real-life rivers, beaches and trails a world away from Orlando's theme parks.
For a start, these mermaids are far from little. Weighing half a ton each and sporting scarred, wrinkled hides, they were first recorded in 1493 by Christopher Columbus, who noted with a crestfallen air "they were not so beautiful as they are described". Indeed not. The West Indian manatee is undeniably one of nature's ugliest creations: a wallowing aquatic mammal that combines the liquid grace of a cow with the cuteness of a warthog.
Yet the experience of swimming among them is breathtaking. Unlike nervy dolphins, placid manatees are comfortable around humans, gliding calmly through underwater foliage with calves in tow. Every winter, hundreds congregate at natural hot springs such as this one at Crystal River on Florida's Gulf Coast, sitting out the cooler months until they can venture out again in search of tasty aquatic weeds.
Captain Joe Detrick of Fun 2 Dive manatee tours runs a strict "no touching" policy. Manatees that become habituated to humans stand a greater risk of running into boats and propellers – the leading cause of death for these endangered creatures. We arrive at the spring just as the local volunteer rescue team is reintroducing an injured female manatee. It's all hands on deck as we hold her down, attach a GPS marker to her muscular tail and carry her – five abreast – down to the water. With a whoop from the crowd and a mighty splash, she surges back into the herd.
My next stop is Wekiwa Springs State Park, near the town of Apopka. Why settle for an artificial river ride in a theme park when for a few dollars you can rent a kayak here and explore the unspoilt Rock Springs Run in virtual solitude? Lush vegetation overhangs the clear waters, giving glimpses of alligators basking in the sun, and the pine forest beyond.
The sub-tropical park also has plenty of hiking trails and several camping grounds with basic facilities (don't forget your mosquito spray). Even this close to the freeways and strip malls of Orlando, wildlife abounds. Deer leap over viciously sharp saw palmettos, while sleek, iridescent wild turkey dart through the undergrowth. Among the leaves and fallen branches, a nine-banded armadillo snuffles for insects. These curious creatures are fearless beneath their armoured scales, rooting busily through the dirt for caterpillars, beetles and termites.
If you're itching for something a little faster-paced, explore Orlando's growing network of bike trails. There is a grand plan to link dozens of trails into a huge loop that will surround this sprawling city, giving an -environmentally friendly alternative to Orlando's choking freeways. While that vision is a long way from being realised, the length of cycle-ways on offer is creeping up every year. A great place to start is the West Orange Trail – one of the longest trails in the Orlando area, running 22 miles along an old railway line.
I pick it up at mile zero, where West Orange Trail Bikes and Blades rents cycles – including the smartest road bike I've ridden. I climb gingerly on to a high-tech Jamis 10-speed and head north-west, along the edge of Lake Apopka. The paved trail is empty enough to coax out my inner Bradley Wiggins (fourth in last year's Tour de France), encouraging me to rattle over a wooden railroad bridge, flash through a nature preserve and pass the historic railway museum without so much as dropping a gear.
The sleepy suburb of Winter Park, where I take a rest stop, has a wholesome downtown which could be the template for Disney's Main Street USA, except here the galleries and cafés are more than façades for fast-food restaurants. An Art Deco cinema stages plays where its silver screen once stood. In the brick-built Edgewater Hotel nearby, retro rules. Its polished wood lobby has a gleaming Otis lift, while a vintage diner serves ice-cream floats and elaborate sundaes.
Winter Park has just legalised the use of electric golf carts on the town's streets to cut emissions and calm traffic. Frankly, it's hard to imagine the sedate drivers here becoming any calmer without slipping into a coma. Even weighed down by two scoops of vanilla, hot fudge and a glacé cherry, I am riding the fastest vehicle in town. I speed under shady live oaks, past high-school football practice and soon find myself in central Florida: aggressive residential developments with fluorescent lawns and over-watered golf courses. The miles slip by, and by the time the trail nudges up next to a highway at mile 14, I'm ready to dodge the golf carts and turn for home.
On my last day in Florida, I wonder whether I've been too dismissive of its theme parks. However, the queues and crowds of Universal, SeaWorld and Walt Disney World still don't appeal, so I drive north to the site of one of the state's first purpose-built resorts. De Leon Springs was named after Juan Ponce de Leon, a Conquistador who may have come to Florida in search of the mythical fountain of youth but ended up settling for gold, slaves and land. The park's centrepiece is a spring boil that pumps out 20 million gallons of warm, sulphurous water daily into a swimming area.
In its heyday in the Fifties, De Leon Springs was a bustling holiday destination with a Spanish-themed hotel, river cruises, a "monkey island", fibre-glass dinosaurs and Queenie, a water-skiing elephant. Now a state park with access to 18,000 acres of lakes, creeks and marshes, it has been largely reclaimed by nature. The remains of the hotel have been converted into changing rooms, paved nature trails have crumbled back into eerie cypress bogs, and monkey island is a few scraps of metal poking from luxuriant bushes by the side of a swamp.
After a hike along the park's five-mile Persimmon Trail, I plunge into the steaming waters of the fountain of youth – the only bather apart from an elderly lady dipping her toes. As I float above the surging boil, heated by water from the spring's subterranean depths, I can't help imagining the Magic Kingdom similarly derelict, its rides gripped by mangroves, car parks carpeted with palms, armadillos grubbing bugs from gift shop walls and manatees soaking in abandoned swimming pools.
It's a wonderful vision that could only be improved upon by the addition of a water-skiing elephant.
Travel essentials
Getting there
*British Airways (0844 493 0787; ba.com) and Virgin Atlantic (0844 209 7777; virgin-atlantic.com) fly non-stop daily from Gatwick to Orlando. There are also charter flights from a range of UK airports to the charter airport, Orlando Sanford International Airport. BA also flies to Tampa.
Staying there
*The Rosen Shingle Creek (001 407 996 9939; rosenshingle creek.com ) has a golf course, swimming pools and luxurious double rooms from $111, excluding breakfast.
*The Edgewater Hotel in Winter Garden (001 407 654 6921; historicedgewater.com) has bed and breakfast from $74 (£49).
*Camping at Wekiwa Springs State Park ( floridastateparks.org/wekiwasprings ) costs $5 (£3.50) per person per night.
More information
*West Orange Trail Bikes and Blades rents bikes (001 407 877 0600; orlando bikerental.com) for $6 (£4) per hour, and $30 (£20) a day.
*Fun 2 Dive scuba and manatee tours (001 888 588 3483; www.fun2dive.com ) has tours for $90 (£60) per person.
- More about:
- Golf
- Orlando
- Swimming
- Walt Disney


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What's causing the Strange Symptoms on the Galaxy S1?
Hi, these are the symptoms of my dysfunctional Galaxy S1 i9000 on froyo 2.2 . Have tested 3 reasonably new batteries & all lose power in a short time. Left standing off the charger, the phone will simply freeze to a black screen everytime & off button wont work- so need to undo battery for a restart. When recharged and/or rebooted the phone has no settings retained eg No contacts, no screen layout, no mobile network registered, no funtional task manager button, etc. GPS starts automatically and google prompts for data backup. No evidence of any extraneous use of battery by any particular function. Have tried new batteries, wiped extraneous apps, unloaded anti-virus security app, and then tried a total factory data reset. No luck. Phone still has ample internal memory. Can you please help fix it ? With many thanks : )
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Holiday Mania at the House of Fun
By (author) Jon Blake
Illustrated by David Roberts
Format: Paperback
Normal Price: $14.99
Your Price: $13.49 AUD, inc. GST
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Availability: Available to Backorder, No Due Date for Supply
Holiday Mania at the House of Fun by Jon Blake
Book DescriptionLooking after the House of Fun can be a hard job, now the Spoonheads have sucked up all the grown-ups into their space zoo. Stinky and Icky decide they need a holiday. But it's not as simple as that. Stinky doesn't seem to have a spare pair of pants. And when Bryan and Icky shrink to the size of nits, they face a bizarre and dangerous journey ...
Buy Holiday Mania at the House of Fun book by Jon Blake from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780340931295
(197mm x 128mm x 9mm)
Pages: 128
Imprint: Hodder Children's Books
Publisher: Hachette Children's Group
Publish Date: 19-Jan-2007
Country of Publication: United Kingdom
Books By Author Jon Blake
Thimble Monkey Superstar, Paperback (May 2016)
Life is never boring now that Jams and his family have a monkey to look after. Jams and his mum love Thimble, but Dad is determined to get rid of him - to a zoo, a school, even a demolition site. But when Jams and his dad are in mortal danger Thimble proves once and for all why he is a Monkey Superstar! Illustrated by Martin Chatterton
Oxford Reading Tree Treetops Greatest Stories: Oxford Level 11: Rip Van Winkle, Paperback (May 2016)
When Rip heads into the mountains, he doesn't expect to be gone long. But on his return home, he finds that everything has changed ... TreeTops Greatest Stories is a series of timeless classics for children aged 711. Its much-loved stories, beautiful artwork and careful levelling make it easy to select books that children will love.
Oxford Reading Tree Treetops Classics: Level 17 More Pack A: Macbeth, Paperback (January 2014)
Macbeth is the story of a noble and courageous man, Macbeth. A chance meeting plants seeds of ambition in his mind. Gripped by the same ambition, Lady Macbeth pushes her husband to gain power, with terrible consequences. TreeTops Classics are adapted and abridged versions of classic stories to enrich and extend children's reading experiences.
Oxford Reading Tree TreeTops Fiction: Level 16 More Pack A: One Girl School, Paperback (January 2014)» View all books by Jon Blake
On her first day at Marnover School Bernie is the first to arriveshe is also the only pupil to arrive in One Girl School. She finds herself in a battle to save the school. But which side is Bernie on? TreeTops Fiction contains engaging novels from top authors and illustrators with the variety children need to develop a love of reading!
» Have you read this book? We'd like to know what you think about it - write a review about Holiday Mania at the House of Fun book by Jon Blake and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Jon Blake
Jon has had a wide variety of jobs, working as a teacher, a university lecturer and even a dustman. His first story was published in 1984 and he has been writing ever since. He has now published over forty books. He lives in Wales, has a pet cat and his favourite food is guacamole.
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Celebrating Lunar New Year
Xue Yao, Ayessa Mae Oasan, Amanda Fung and Ayesa-Bianca Depalma paint Chinese fan art in celebration of the Lunar New Year on Jan. 28 during an event sponsored by Late Nite Binghamton.
Photo by Emily Lubin
News Briefs
Nominations sought for the Provost's Award for Excellence in Undergraduate Research Mentoring
February 22, 2017
For more information, go online. Contact Don Loewen at 607-777-2142 or via e-mail with questions.
CARE study on suicide attempts seeks participants
February 22, 2017
Career coaching: In person or on the phone
February 22, 2017
Wojcio is a certified career coach who can be reached via e-mail. Binghamton University continues to provide this career/professional development service for all its employees.
February 21, 2017
February 21, 2017
February 21, 2017
The group will be held from 5:30-6:30 p.m. Tuesdays in the LGBTQ Center Conference Room (LS-G652), starting Feb. 21. Questions can be directed to Tracy Lord.
NYS Deferred Compensation rep on campus March 2
February 21, 2017
February 21, 2017
• Immigration: Let us help you understand the process involved when a department is looking to hire a foreign national, from advertising up through the hiring process, including all requirements and expenses involved. This session will be held from 10 a.m.-noon Tuesday, Feb. 28, in UUW-324. Sign up online at HR Employment Training Series.
'A Lie of the Mind' theater production
February 20, 2017
As the play opens, Jake, blinded by jealousy and rage, believes he may have killed his wife. While Jake seeks refuge in the home of his widowed mother, his brother Frankie goes to investigate and soon finds himself caught in the confusing currents of revenge and longing. Called "a hilarious reverie about parents and children and husbands and wives set in the mythic wilderness of Americana," A Lie of the Mind depicts two families shaken by sudden violence and their journey toward healing.
A Lie of the Mind will be performed at 8 p.m. Feb. 24 and 25, and March 10 and 11; and at 2 p.m. March 12, in FA-Watters Theater.
Ticket prices are $18, general; $16, alumni/faculty/senior/staff; $10, student
Purchase advance tickets at the Box Office in the Anderson Center for the Performing Arts or call 607-777-2787. Tickets available online (fees apply).
More information about the show, parking and the production is available online.
February 17, 2017
February 16, 2017
February 16, 2017
February 16, 2017
Costs: $195 for each program. Two scholarships are available for the Kids or Teens program (teacher recommendation required - see website for instructions).
For more information, contact at 607-777-4786 or via email, or visit CAP's website.
February 15, 2017
Postdoctoral Research Associate-Psychology/Electrophysiology
HR Boot Camp: Professional Employment
February 14, 2017
• Professional Employment: Professional staff includes UUP and Management/Confidential, with a wide variety of titles and responsibilities. At this session from 10 a.m.-noon Tuesday, March 14, in UUW-324, HR staff will walk you through the process of recruitment, hire, renewals, performance programs and evaluations, promotions/reclassifications, time and attendance, and other aspects of handling professional employment needs in your department. Sign up online at HR Employment Training Series.


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Find out what happens next on Binnelanders in October 2016: Watch Binnelanders Episodes and Teasers online.
Find out what happens next on Binnelanders in October 2016:
Watch Binnelanders Episodes and Teasers online.
Monday 3 October 2016
Episode 0081/2577
Louis feels he has something to prove, while Okkie confronts Naomi about her secret meeting with Belinda. Adventure seems to be lacking in Venice, and Marissa puts her foot firmly down with Annelize. Naomi tries really hard to make an emotional connection, and a desperate plea reaches Ilse.
Tuesday 4 October 2016
Episode 0082/2578
Relaxation comes with time - as well as conversations about previous relationships and wrong choices. Okkie tries his best to do the right thing, while Annelize feels humiliated when she questions an appointment. Wilmien has to listen to Karli bemoan her fate, while Naomi questions all her relationships.
Wednesday 5 October 2016
Episode 0083/2579
A conversation leaves Marissa cold, and an uncomfortable conversation after the previous night's dinner ensues. Liam is admitted to hospital - and then the heartbreak unfolds.
A night at the opera might just be what the doctor ordered, while Boeta's reaction doesn't sit well with Okkie. Pippa is worried about Annelize and Marissa, but Naomi feels she doesn't fit in anywhere. Peace is made but Jana is left speechless…
Thursday 6 October 2016
Episode 0084/2580
Okkie resents Ilse's support, while Louis explains his plan to Deon. Marissa is not happy with Annelize's findings, and Tertius and Karli's reactions speak volumes about an entrepreneur's business acumen.
Steve has a plan for Nagskof, while Naomi shares big news with Okkie. Marissa opens up towards Annelize, and Naomi gets support from an unlikely source.
Friday 7 October 2016
Episode 0085/2581
Annelize is unsure about the path ahead where Liam is concerned, while Deon is unsure about a dartboard. Karli thinks Annelize is heartless, while the news about Belinda spreads.
An ex and answers make a doctor feel trapped, and another doctor explains the invasive procedure that could eliminate a possible sickness. Naomi is unsure about Desiré, while good news is celebrated with an unexpected kiss.
Monday 10 October 2016
Episode 0086/2582
Annelize takes her frustration out on Wilmien, while Naomi doesn't trust the peace. Pippa voices her concerns about Tertius, and Ilse gives Belinda a warning.
Breggie's story makes Annelize see things differently, while Steve and Deon have a surprise for Louis. Tertius tries to rectify things with Marissa, and a good laugh leads to 'tragedy' in Nagskof.
Tuesday 11 October 2016
Episode 0087/2583
Annelize explains her suspicions to Naomi, while bad news is shared in Tonik. Pippa is going to report a certain doctor, and Marissa finds out about Annelize's history. Belinda has a strategy for the future, while Annelize looks to Conrad for support.
Wednesday 12 October 2016
Episode 0088/2584
Wilmien thinks she should move out, while Naomi is worried about Annelize's behaviour. Louis finds out more about Conrad and Pippa's history, while Conrad places Wilmien in an uncomfortable situation.
Tertius hears about Annelize's accusations, and Karli challenges Wilmien about a doctor's behaviour. Louis is talked into something and Conrad's suspicions lead him to take action.
Thursday 13 October 2016
Episode 0089/2585
Conrad spells out the danger of what they are busy with, while Marissa needs a place to stay. Wilmien stands her ground, and Wimpie and Deon challenge each other. A doctor opens up about his feelings, while Liam gets a new doctor. A mother is a master manipulator.
Friday 14 October 2016
Episode 0090/2586
Wilmien is caught off guard, while a teddy bear could provide some answers. Karli's complaints surprise Louis, while Pippa asks Bronwyn for a favour. Naomi is aware that Marissa is not herself, and Wimpie tries to convince Okkie to join the league.
Flowers cause a misunderstanding, while 'attractive' makes it even worse. Karli walks in on a very strange scenario.
Monday 17 October 2016
Episode 0091/2587
Pippa dissects her feelings, while Tertius explains to Annelize what is going on with Liam. Annelize is frustrated with her situation, and Pippa makes things very clear to Conrad. The Ferreiras might have a new tenant, while a conversation between Bronwyn and Steve is clearly not about them. Karli insists on an injection.
Tuesday 18 October 2016
Episode 0092/2588
Wilmien is sure that Conrad is not interested in her, and Ilse asks Okkie to remember team spirit at the end of the day. Naomi and Annelize argue about Annelize's attitude, and Pippa informs Bronwyn about two people's history. Conrad longs for simpler days, while a patient is in distress. Marissa is put in her place.
Wednesday 19 October 2016
Episode 0093/2589
Naomi tries to convince Annelize to stop spying, while Bronwyn has news for Marissa about Liam. A teddy bear lands in the wrong hands and could lead to big trouble, and Pippa explains to Wilmien why a doctor behaved in a certain way.
Okkie doesn't understand Naomi's behaviour, while Ilse wants to warn the young ones about hidden talents. Bronwyn witnesses something that she probably shouldn't have.
Thursday 20 October 2016
Episode 0094/2590
A conversation gives Conrad new insights, while Bronwyn wants to get to the bottom of things. Pippa gives a nurse a warning, and Karli is given a strange task. Louis is witness to an uncomfortable interaction, while Annelize pleads desperately with Bronwyn. A father could hold the answers to many inexplicable problems.
Friday 21 October 2016
Episode 0095/2591
Marissa is put to the test, and Pippa doesn't agree with Conrad's choice. Annelize thinks she knows what they should do next, while Noami will have to think fast if she doesn't want to get into trouble. Bronwyn tries to distract her friend, and Jana is back from overseas.
Monday 24 October 2016
Episode 0096/2592
At gets an interesting welcome on his return from Venice. Bronwyn experiences Marissa's manipulation first hand, while Conrad and Louis make peace. Naomi realises what is really going on, and Conrad makes a decision about a nurse. Annelize asks Bronwyn to stay away from Marissa – but asks Naomi to get her hands on an injection.
Tuesday 25 October 2016
Episode 0097/2593
At wants to get rid of Louis, while Marissa's past catches up with her. There is an awkwardness between Wilmien and Pippa, as well as At and Jana. Annelize and Bronwyn try to make sense of the information that they got from Medi-Tech, and Karli sees her mother is still stressed. A very passionate kiss could defuse a tense situation, while Bronwyn has very encouraging news for Marissa.
Wednesday 26 October 2016
Episode 0098/2594
Conrad tries to warn Tertius against Marissa, while Ilse asks Jana about her holiday. Marissa insists on an invasive operation for Liam, and Wilmien's head is in the clouds. Liam shocks Tertius, and a new pairing has the tongues wagging. At takes control of a situation, and Tertius voices his concerns towards Annelize.
Thursday 27 October 2016
Episode 0099/2595
Conrad expects At to be honest with him, while Ilse has a very hard talk with Wilmien. Annelize disappears – but arrives with answers. Jana opens up to Ilse, while Wilmien is intimidated by the Koster Mansion, and Karli is apparently not Karli.
Friday 28 October 2016
Episode 0100/2596
It is not just Karli that is in mortal danger. Louis thinks that Conrad should put his ghosts to rest while Wilmien is unsure about matters of the heart. At fears the future that he sees as his future and Pippa is placed in an uncomfortable situation. Jana is panic stricken while Annelize's distress turns into rage.
Monday 31 October 2016
Episode 0101/2597
Ryno tells Jana and At everything about Marissa, and Wilmien thinks Conrad has forgotten their date. Liebenberg can't believe what Annelize has done, and both Steve and Bronwyn find themselves in a strange situation.
Two doctors will have to do everything in their power to save Karli's life. Naomi blames herself for the mess, while Jana is inconsolable.


text:
Created attachment 571501 [details] [diff] [review]
[checked in] Disable the cache - v1
+++ This bug was initially created as a clone of Bug #697553 +++
Since offline support has landed, both gdata and wcap need some updating. This bug covers wcap support.
First of all, here is a patch that just disables the cache for wcap in total. I know this sucks, but before I break a provider in total I'd rather provide a workaround that successfully migrates users for the time being.
I've tested the upgrade path from cached to no cache and its not noticeable. As soon as the real fix lands, users are then auto-upgraded to using the cache again on restart.
Comment on attachment 571501 [details] [diff] [review]
[checked in] Disable the cache - v1
I'm going to go this route for the release to make sure I'm not rushing in more big features. Leaving the bug open for the real patch, which should make the next release in 7 weeks.
comm-central changeset cda39712fdae
releases/comm-aurora changeset 01a98a8c26a5
releases/comm-beta changeset c47c0a0a785e
Hello WCAP Folks,
as mentioned in my previous comment, unfortunately I cannot enable the cache in the next release. I'd be interested to hear how many users are behind your WCAP system and how many of them use Lightning. Is Thunderbird/Lightning managed by your IT department, and if so how is the update policy?
For the release you will have two options:
* Do nothing and the cache will be temporarily disabled.
* Stay with the last release until this bug is fixed
Let me know how this works out for you. Also, if you can convince your mangement to invest developer resources into Lightning this would be marvelous. WCAP currently works, but since its not in my primary focus I can't forsee if any new server patchlevels break the provider and as you've seen before with bug 679669, platform changes that break WCAP might also creep in unannounced.
*** Bug 702554 has been marked as a duplicate of this bug. ***
(In reply to Philipp Kewisch [:Fallen] from comment #2)
Philipp, I sent you a mail about our use of WCAP at your registered mail address in bugzilla, but I wonder whether this address is a technical one or a real personal one.
Laurent, I recevied your email and will reply soon. Thanks for the infos!
At my work, we use this functionality(wcap offline support) since about 1 year because we have network problem. When I'm disconnected, I loose everything.
When do you plan to enable the cache again.
Thanks for your help.
If I get to pick, then I'd rather like to do some changes to the offline interfaces, which might make adaptions to wcap unneeded or very minimal.
Also, thanks for commenting. That reminds me I need to reply to an email!
Hi Philipp,
Still waiting for your work ... ;-)
When do you plan to do it ?
Hi Philip,
I've got no answer from you ....
Will you enable the cache again for wcap ?
Now I use TB 7.0 and Lightning 1.0b7 to keep the cache functionality.
Thx for your response and have a good day.
Hi! I have a patch almost working that changes the offline API so that no further methods are needed, which means the cache can be enabled again.
It still needs some testing and I need to find out if a certain case will cause an endless loop or not.
I haven't opened a bug for it yet, but I'll make it block this one so you are in the loop.
Created attachment 647137 [details] [diff] [review]
Fix calIChangeLog Implementation - v1
This patch fixes the calIChangeLog listener implementation and requires a nightly with bug 756052 applied (tomorrow).
One thing I noticed is that cached WCAP is also showing symptoms of bug 717067, but I think its more minor, the main thing is to get this running.
Comment on attachment 647137 [details] [diff] [review]
Fix calIChangeLog Implementation - v1
Review of attachment 647137 [details] [diff] [review]:
Looks alright to me, a couple of style fixes. How to test. Is there a WCAP version available online for testing? and looks like I need to look into bug 717067 pretty soon.
::: calendar/providers/wcap/calWcapCalendarItems.js
@@ +583,4 @@
> }
> var items = this_.parseItems(icalRootComp, calICalendar.ITEM_FILTER_ALL_ITEMS,
> 0, null, null, true /* bLeaveMutable */);
> + if (items.length != 1) {
Should we collapse the two cases? one is a Components.Exception the other is just a console error.
@@ +1324,1 @@
> var this_ = this;
you can use this opportunity to correct the vars into let ;)
I'd like to leave the wcap provider alone as much as possible. If I start fixing nits on it then I will end with regressions and need start doing large scale changes.
comm-central changeset 7155880be5bb


text: DC's first comic book based on Smallville has hit stands today! The comic includes stories by Smallville writer Mark Verheiden and what looks like fantastic artwork by Roy Allan Martinez and John Paul Leon. Included will also be features about the show's production and the new season. Also, only the comic book will offer the key to how to get into Chloe's "Wall of Weird," launching today at www.wallofweird.com so pick it up! According to www.kryptonsite.com , Supposedly one can visit the online Smallville Torch and find a secret way to access Chloe's files with a password found only in the comic book. Let the challenge begin! Comments?


text:
Cream Of Corn Soup
9 Nov 2009
Cream Of Corn Soup is a yummy soup that will surely addict your guests to its lovely flavor and richness in minutes! I served the Cream Of Corn Soup last week for my wedding anniversary. Needless to say, my husband loved it!
|White sauce
|2 Cup (32 tbs)
|Boiling water
|2 Cup (32 tbs)
|Creamed corn
|2 Cup (32 tbs)
|Onion slices
1. Cook corn and onion in boiling water for 20 minutes.
2. Press through a sieve smoothly.
3. Make white sauce in a double boiler.
4. Add strained corn, reheat and serve.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 804 Calories from Fat 281
% Daily Value*
Total Fat 32 g49.7%
Saturated Fat 10.3 g51.7%
Trans Fat 0 g
Cholesterol 38.4 mg12.8%
Sodium 3068.6 mg127.9%
Total Carbohydrates 103 g34.3%
Dietary Fiber 4.4 g17.6%
Sugars 45.6 g
Protein 22 g43.9%
Vitamin A 20% Vitamin C 14.3%
Calcium 62.3% Iron 5.8%
*Based on a 2000 Calorie diet
Cream Of Corn Soup Recipe


text:
More Kids, More Opportunities, More Skills
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